5000000@unknown@formal@none@1@S@Induction of NF-KB during monocyte differentiation by HIV type 1 infection.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-KB") (:form . "NF-KB") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.1) (:did . :|91079577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000001@unknown@formal@none@1@S@The production of human immunodeficiency virus type 1 (HIV-1) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA, and in purified human monocytes and macrophages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 40) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 107)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 135)\n  (:start . 124) (:id . 63))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 142)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 185)\n  (:start . 177) (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 201)\n  (:start . 192) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 217)\n  (:start . 206) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1.2) (:did . :|91079577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000002@unknown@formal@none@1@S@Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor NF-KB to the double repeat-KB enhancer sequence located in the long terminal repeat.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "southwestern") (:form . "Southwestern") (:end . 54)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 63)\n  (:start . 55) (:id . 48))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 75)\n  (:start . 64) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 85) (:start . 81)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 95)\n  (:start . 89) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 135) (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 59))\n ((:tag . "NN") (:stem . "nf-kb") (:form . "NF-KB") (:end . 148)\n  (:start . 143) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 162)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "repeat-kb") (:form . "repeat-KB") (:end . 172)\n  (:start . 163) (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 181)\n  (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 190)\n  (:start . 182) (:id . 66))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 198)\n  (:start . 191) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 210) (:start . 206)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 219)\n  (:start . 211) (:id . 71))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 226)\n  (:start . 220) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1.3) (:did . :|91079577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000003@unknown@formal@none@1@S@PMA treatment, and not retinoic acid treatment of the U937 cells acts in inducing NF-KB expression in the nuclei.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-KB") (:form . "NF-KB") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1.4.1) (:span 19 22)))\n (:nscopes ((:id . :x1.4.1) (:span 19 64)))\n (:identifiers (:sid . :s1.4) (:did . :|91079577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000004@unknown@formal@none@1@S@In nuclear extracts from monocytes or macrophages, induction of NF-KB occurred only if the cells were previously infected with HIV-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-KB") (:form . "NF-KB") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.5) (:did . :|91079577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5000006@unknown@formal@none@1@S@These results indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation/activation")\n  (:form . "differentiation/activation") (:end . 104) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 129)\n  (:start . 122) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-KB") (:form . "NF-KB") (:end . 135)\n  (:start . 130) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1.7.1) (:span 61 66)) ((:id . :x1.7.2) (:span 14 27)))\n (:hscopes ((:id . :x1.7.1) (:span 61 146)) ((:id . :x1.7.2) (:span 14 146)))\n (:identifiers (:sid . :s1.7) (:did . :|91079577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000007@unknown@formal@none@1@S@Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 50) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 93) (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.1) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000008@unknown@formal@none@1@S@A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 21) (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "e4") (:form . "E4") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "octamerlike") (:form . "octamerlike") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 122) (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 134)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.2) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000010@unknown@formal@none@1@S@Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG, designated E6, was protected by nuclear extracts from B cells, T cells, or HeLa cells.@(((:tag . "NNP") (:stem . "Footprinting") (:form . "Footprinting") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "ccgaaactgaaaagg") (:form . "CCGAAACTGAAAAGG")\n  (:end . 74) (:start . 59) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 86)\n  (:start . 76) (:id . 51))\n ((:tag . "NNP") (:stem . "E6") (:form . "E6") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "protect") (:form . "protected") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 155) (:start . 151)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x2.4.1) (:span 148 150)))\n (:hscopes ((:id . :x2.4.1) (:span 130 161)))\n (:identifiers (:sid . :s2.4) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000011@unknown@formal@none@1@S@Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "e6") (:form . "E6") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 79) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.5) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000012@unknown@formal@none@1@S@In agreement with the results of gel retardation assays, tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 70) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "E6") (:form . "E6") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "ARH77") (:form . "ARH77") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 161) (:start . 157)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x2.6.1) (:span 154 156)))\n (:ncues ((:id . :x2.6.2) (:span 140 143)))\n (:hscopes ((:id . :x2.6.1) (:span 147 161)))\n (:nscopes ((:id . :x2.6.2) (:span 140 167)))\n (:identifiers (:sid . :s2.6) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000013@unknown@formal@none@1@S@Furthermore, a mutant E6 motif lost both in vitro binding activity and in vivo enhancer activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "e6") (:form . "E6") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "lose") (:form . "lost") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.7) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000014@unknown@formal@none@1@S@In striking contrast to the mouse Ig heavy-chain enhancer, in which the octamer motif acts as a B-cell-specific enhancer element, the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ig") (:form . 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"of") (:end . 308) (:start . 306)\n  (:id . 89))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 312) (:start . 309)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 316) (:start . 313)\n  (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 317) (:start . 316)\n  (:id . 92)))@@@1@51@((:ncues ((:id . :x2.8.1) (:span 285 287)))\n (:nscopes ((:id . :x2.8.1) (:span 285 316)))\n (:identifiers (:sid . :s2.8) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000015@unknown@formal@none@1@S@Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MnlI-AluI") (:form . "MnlI-AluI") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "basal-level") (:form . "basal-level") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "conalbumin") (:form . "conalbumin") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x2.9.1) (:span 38 43)))\n (:hscopes ((:id . :x2.9.1) (:span 38 134)))\n (:identifiers (:sid . :s2.9) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000016@unknown@formal@none@1@S@Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MnlI-AluI") (:form . "MnlI-AluI") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x2.10.1) (:span 100 103)))\n (:nscopes ((:id . :x2.10.1) (:span 100 114)))\n (:identifiers (:sid . :s2.10) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000017@unknown@formal@none@1@S@Thus, the novel enhancer element identified in this study is probably a target site for both positive and negative factors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x2.11.1) (:span 61 69)))\n (:hscopes ((:id . :x2.11.1) (:span 61 122)))\n (:identifiers (:sid . :s2.11) (:did . :|91094881|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000018@unknown@formal@none@1@S@The NF kappa B independent cis-acting sequences in HIV-1 LTR responsive to T-cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s3.1) (:did . :|91101115|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000020@unknown@formal@none@1@S@Here we show that the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "govern") (:form . "governed") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 82)\n  (:start . 71) (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 66))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 143)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 153)\n  (:start . 144) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 163) (:start . 159)\n  (:id . 70))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 170)\n  (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 177)\n  (:start . 171) (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 180) (:start . 178)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 183) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 189)\n  (:start . 184) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x3.3.1) (:span 48 51)))\n (:hscopes ((:id . :x3.3.1) (:span 18 191)))\n (:identifiers (:sid . :s3.3) (:did . :|91101115|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000021@unknown@formal@none@1@S@The rate of LTR-directed gene expression increased in response to treatment with either a phorbol ester or tumor necrosis factor alpha if either the NFAT-1 or NF kappa B binding sites were deleted, but failed to respond to these mitogenic stimuli if both sequences were absent.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ltr-directed") (:form . "LTR-directed") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . 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5000022@unknown@formal@none@1@S@The HIV-1 mutant virus containing both NF kappa B and NFAT-1 deletion was able to replicate although at a much decreased growth rate, while the deletion of NFAT-1 alone increased the viral growth rate in Jurkat cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 152)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NFAT-1") (:form . "NFAT-1") (:end . 162)\n  (:start . 156) (:id . 70))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 188)\n  (:start . 183) (:id . 74))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 195)\n  (:start . 189) (:id . 75))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 200) (:start . 196)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 210)\n  (:start . 204) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 216)\n  (:start . 211) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s3.5) (:did . :|91101115|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000023@unknown@formal@none@1@S@Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFAT-1") (:form . "NFAT-1") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x3.6.1) (:span 0 7 31 34)))\n (:nscopes ((:id . :x3.6.1) (:span 0 112)))\n (:identifiers (:sid . :s3.6) (:did . :|91101115|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000024@unknown@formal@none@1@S@Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 112)\n  (:start . 106) (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 138)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.1) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000025@unknown@formal@none@1@S@Interferons (IFNs) are well known both as antiviral proteins and as potent regulators of cell growth and differentiation.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferons") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 120) (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.2) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000026@unknown@formal@none@1@S@In fact, IFNs inhibit growth of various normal and transformed cell types.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "ifn") (:form . "IFNs") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.3) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000027@unknown@formal@none@1@S@Previously, a nuclear factor, IRF-1 (interferon regulatory factor 1), which binds to type I IFN and some IFN-inducible gene promoters, was identified and cloned.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 62))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 104) (:start . 100)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "ifn-inducible") (:form . "IFN-inducible")\n  (:end . 118) (:start . 105) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 133)\n  (:start . 124) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 138) (:start . 135)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 149)\n  (:start . 139) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s4.4) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000028@unknown@formal@none@1@S@Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intriguing") (:form . "intriguing") (:end . 67)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 97)\n  (:start . 90) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 107)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "function") (:form . "functioning") (:end . 127)\n  (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ifn-mediated") (:form . "IFN-mediated") (:end . 143)\n  (:start . 131) (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 154)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 70))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 169)\n  (:start . 163) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 189) (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x4.5.1) (:span 90 97)) ((:id . :x4.5.2) (:span 68 83)))\n (:hscopes ((:id . :x4.5.1) (:span 90 189)) ((:id . :x4.5.2) (:span 68 189)))\n (:identifiers (:sid . :s4.5) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000030@unknown@formal@none@1@S@In the transgenic mice, all the lymphoid tissues examined showed a dramatic reduction in the number of B lymphocytes (B cells).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 64) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.7) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000031@unknown@formal@none@1@S@Preparation and analysis of bone marrow cells from the chimeric mice indicated that the bone marrow is the effective site for specific depletion of the B-cell population.@(((:tag . "NNP") (:stem . "Preparation") (:form . "Preparation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x4.8.1) (:span 69 83)))\n (:hscopes ((:id . :x4.8.1) (:span 69 169)))\n (:identifiers (:sid . :s4.8) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000032@unknown@formal@none@1@S@In fact, transgenic bone marrow cells cocultured with a bone marrow-derived stromal cell line revealed an altered B-cell maturation pattern.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "coculture") (:form . "cocultured") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "marrow-derived") (:form . "marrow-derived")\n  (:end . 75) (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "stromal") (:form . "stromal") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.9) (:did . :|91110562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000033@unknown@formal@none@1@S@Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 60) (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 112) (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.1) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000034@unknown@formal@none@1@S@CD3-epsilon expression is controlled by a downstream T lymphocyte-specific enhancer element.@(((:tag . "NNP") (:stem . "CD3-epsilon") (:form . "CD3-epsilon") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 74) (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s5.2) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000035@unknown@formal@none@1@S@We report the identification of a T cell-specific transcription factor, TCF-1, binding to this element.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.3) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000036@unknown@formal@none@1@S@The multimerized recognition motif of TCF-1 constituted a T cell-specific enhancer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "constitute") (:form . "constituted") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s5.4) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000037@unknown@formal@none@1@S@Subsequent cloning of TCF-1 identified three splice alternatives.@(((:tag . "JJ") (:stem . "subsequent") (:form . "Subsequent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "alternative") (:form . "alternatives") (:end . 64)\n  (:start . 52) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s5.5) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000038@unknown@formal@none@1@S@TCF-1 contained a single DNA-binding HMG box most closely related to similar boxes in the putative mammalian sex-determining gene SRY and in the Schizosaccharomyces pombe Mc mating type gene.@(((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "sex-determining") (:form . "sex-determining")\n  (:end . 124) (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "FW") (:stem . "schizosaccharomyces")\n  (:form . "Schizosaccharomyces") (:end . 164) (:start . 145) (:id . 65))\n ((:tag . "FW") (:stem . "pombe") (:form . "pombe") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . "NNP") (:stem . "Mc") (:form . "Mc") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mating") (:form . "mating") (:end . 180)\n  (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 185) (:start . 181)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x5.6.1) (:span 90 98)))\n (:hscopes ((:id . :x5.6.1) (:span 90 133)))\n (:identifiers (:sid . :s5.6) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000040@unknown@formal@none@1@S@Upon cotransfection into non-T cells, TCF-1 could transactivate through its cognate motif.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x5.8.1) (:span 44 49)))\n (:hscopes ((:id . :x5.8.1) (:span 44 89)))\n (:identifiers (:sid . :s5.8) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000041@unknown@formal@none@1@S@These results identify TCF-1 as a T cell-specific transcription factor, which might play a role in the establishment of the mature T cell phenotype.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "establishment") (:form . "establishment")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 147)\n  (:start . 138) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x5.9.1) (:span 78 83)))\n (:hscopes ((:id . :x5.9.1) (:span 78 147)))\n (:identifiers (:sid . :s5.9) (:did . :|91114695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000042@unknown@formal@none@1@S@Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.1) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000043@unknown@formal@none@1@S@Upon activation, T lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of proenkephalin mRNA in the cells.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "accumulate") (:form . "accumulate") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "neuropeptide") (:form . "neuropeptide") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "enkephalin") (:form . "enkephalin") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 134) (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s6.2) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000044@unknown@formal@none@1@S@Here we investigated the transcriptional basis for these changes.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.3) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000045@unknown@formal@none@1@S@The proenkephalin promoter contains a sequence GGGGACGTCCCC, named B2, which is similar to the kappa B sequence GGGGACTTTCC, the binding site of the transcription factor nuclear factor (NF)-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "GGGGACGTCCCC") (:form . "GGGGACGTCCCC") (:end . 59)\n  (:start . 47) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "GGGGACTTTCC") (:form . "GGGGACTTTCC") (:end . 123)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 162) (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 169)\n  (:start . 163) (:id . 69))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 184)\n  (:start . 178) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 195)\n  (:start . 186) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 197) (:start . 196)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s6.4) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000046@unknown@formal@none@1@S@Activation of T lymphocytes induces an NF-kappa B-like binding activity to the B2 site, concomitant with activation of the proenkephalin promoter.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 136) (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.5) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000047@unknown@formal@none@1@S@Mutations at the B2 site abolish this transcriptional activation.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "abolish") (:form . "abolish") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.6) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000048@unknown@formal@none@1@S@The purified homodimer (two p50s) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s) form of the factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "p50") (:form . "p50s") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 52)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 109) (:start . 96) (:id . 61))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "heterotetramer") (:form . "heterotetramer")\n  (:end . 156) (:start . 142) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "p65") (:form . "p65s") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "p50") (:form . "p50s") (:end . 180) (:start . 176)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 200)\n  (:start . 194) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.7) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000050@unknown@formal@none@1@S@However, as NF-kappa B is ubiquitous and the transcriptional activation through the B2 site is T cell specific, yet another T-cell-specific factor which synergizes with NF-kappa B should be considered.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 60) (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 139) (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "VBZ") (:stem . "synergize") (:form . "synergizes") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 186)\n  (:start . 180) (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 200)\n  (:start . 190) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x6.9.1) (:span 180 186)))\n (:hscopes ((:id . :x6.9.1) (:span 112 200)))\n (:identifiers (:sid . :s6.9) (:did . :|91117203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000051@unknown@formal@none@1@S@Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 52) (:start . 37) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral-blood") (:form . "peripheral-blood")\n  (:end . 78) (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s7.1) (:did . :|91119580|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000052@unknown@formal@none@1@S@We have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral-blood") (:form . "peripheral-blood")\n  (:end . 50) (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 86) (:start . 72) (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 98)\n  (:start . 87) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 105)\n  (:start . 99) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 124) (:start . 109) (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 130)\n  (:start . 125) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 57))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 135) (:start . 132)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.2) (:did . :|91119580|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000053@unknown@formal@none@1@S@Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta-phorbol") (:form . "beta-phorbol") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 73)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 140)\n  (:start . 129) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 155)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.3) (:did . :|91119580|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000054@unknown@formal@none@1@S@The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 26) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 57)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 101) (:start . 96)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "reach") (:form . "reached") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 135)\n  (:start . 126) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s7.4) (:did . :|91119580|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000055@unknown@formal@none@1@S@These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 111)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 127) (:start . 112) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "functionality") (:form . "functionality")\n  (:end . 170) (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x7.5.1) (:span 128 130)) ((:id . :x7.5.2) (:span 70 75))\n  ((:id . :x7.5.3) (:span 14 21)))\n (:hscopes ((:id . :x7.5.1) (:span 88 170)) ((:id . :x7.5.2) (:span 27 170))\n  ((:id . :x7.5.3) (:span 14 170)))\n (:identifiers (:sid . :s7.5) (:did . :|91119580|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000056@unknown@formal@none@1@S@Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line.@(((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "Platelet-activating") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 26)\n  (:start . 20) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 34)\n  (:start . 27) (:id . 44))\n ((:tag . "JJ") (:stem . "phospholipid") (:form . "phospholipid") (:end . 47)\n  (:start . 35) (:id . 45))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 56)\n  (:start . 48) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "flux") (:form . "flux") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 83)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "liberation") (:form . "liberation") (:end . 99)\n  (:start . 89) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "eicosanoid") (:form . "eicosanoid") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 122)\n  (:start . 112) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 158)\n  (:start . 153) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 160) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s8.1) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000057@unknown@formal@none@1@S@Platelet-activating factor is a potent mediator of the inflammatory response.@(((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "Platelet-activating") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 26)\n  (:start . 20) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 67)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s8.2) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000058@unknown@formal@none@1@S@Studies of the actions of platelet-activating factor have centered mainly around neutrophils, monocytes, and platelets.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 45) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 92)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s8.3) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000060@unknown@formal@none@1@S@Employing the EBV-transformed human B cell line SKW6.4, we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine, phosphatidylinositol, and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M.@(((:tag . "VBG") (:stem . "employ") (:form . "Employing") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . 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5000061@unknown@formal@none@1@S@The inactive precursor, lyso-platelet-activating factor, at a concentration as high as 10(-7) M had no effect on any of the membrane phospholipids.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lyso-platelet-activating")\n  (:form . "lyso-platelet-activating") (:end . 48) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 55)\n  (:start . 49) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 75) (:start . 62) (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "10(-7)") (:form . "10(-7)") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "phospholipid") (:form . "phospholipids")\n  (:end . 146) (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x8.6.1) (:span 100 102)))\n (:nscopes ((:id . :x8.6.1) (:span 100 146)))\n (:identifiers (:sid . :s8.6) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000062@unknown@formal@none@1@S@We also show that platelet-activating factor from 10(-12) to 10(-6) M induced rapid and significant elevation in intracellular calcium levels, whereas lyso-platelet-activating factor was again ineffective.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 37) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "10(-12)") (:form . "10(-12)") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "10(-6)") (:form . "10(-6)") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 126) (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "JJ") (:stem . "lyso-platelet-activating")\n  (:form . "lyso-platelet-activating") (:end . 175) (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 182)\n  (:start . 176) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 186) (:start . 183)\n  (:id . 66))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 192)\n  (:start . 187) (:id . 67))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 204)\n  (:start . 193) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s8.7) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000063@unknown@formal@none@1@S@We further demonstrate the impact of platelet-activating factor binding to B cells by measuring platelet-activating factor induced arachidonic acid release and 5-hydroxyeicosatetraenoic acid production.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 56) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "measure") (:form . "measuring") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 115) (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 122)\n  (:start . 116) (:id . 57))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 130)\n  (:start . 123) (:id . 58))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 142)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 155)\n  (:start . 148) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "5-hydroxyeicosatetraenoic")\n  (:form . "5-hydroxyeicosatetraenoic") (:end . 185) (:start . 160)\n  (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 190) (:start . 186)\n  (:id . 64))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 201)\n  (:start . 191) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s8.8) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000064@unknown@formal@none@1@S@Moreover, platelet-activating factor was capable of inducing transcription of the nuclear proto-oncogenes c-fos and c-jun.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 29) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 105) (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 111)\n  (:start . 106) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 121)\n  (:start . 116) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s8.9) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000065@unknown@formal@none@1@S@Finally we explored the possible role of 5-hydroxyeicosatetraenoic acid as a regulator of arachidonic acid liberation demonstrating that endogenous 5-lipoxygenase activity modulates platelet-activating factor induced arachidonic acid release perhaps acting at the level of phospholipase A2.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "explore") (:form . "explored") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "5-hydroxyeicosatetraenoic")\n  (:form . "5-hydroxyeicosatetraenoic") (:end . 66) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "liberation") (:form . "liberation") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 131) (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 147)\n  (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 162) (:start . 148) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 171)\n  (:start . 163) (:id . 62))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 181)\n  (:start . 172) (:id . 63))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 201) (:start . 182) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 208)\n  (:start . 202) (:id . 65))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 216)\n  (:start . 209) (:id . 66))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 228)\n  (:start . 217) (:id . 67))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 233) (:start . 229)\n  (:id . 68))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 241)\n  (:start . 234) (:id . 69))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 249)\n  (:start . 242) (:id . 70))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 256)\n  (:start . 250) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 259) (:start . 257)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 263) (:start . 260)\n  (:id . 73))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 269)\n  (:start . 264) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 272) (:start . 270)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 286) (:start . 273) (:id . 76))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 289) (:start . 287)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x8.10.1) (:span 242 249)) ((:id . :x8.10.2) (:span 24 32)))\n (:hscopes ((:id . :x8.10.1) (:span 242 289))\n  ((:id . :x8.10.2) (:span 24 117)))\n (:identifiers (:sid . :s8.10) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000066@unknown@formal@none@1@S@In summary, platelet-activating factor is shown here to have a direct and profound effect on a pure B cell line.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 31) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pure") (:form . "pure") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.11) (:did . :|91132035|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000067@unknown@formal@none@1@S@A novel HIV-1 isolate containing alterations affecting the NF-kappa B element.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "isolate") (:form . "isolate") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s9.1) (:did . :|91134976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000068@unknown@formal@none@1@S@Three molecular clones of HIV-1, derived from a single isolate (AL1), exhibited distinct replicative and cytopathic properties during propagation in a human T cell line.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "isolate") (:form . "isolate") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AL1") (:form . "AL1") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 79)\n  (:start . 70) (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 100)\n  (:start . 89) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cytopathic") (:form . "cytopathic") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "propagation") (:form . "propagation") (:end . 145)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s9.2) (:did . :|91134976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000070@unknown@formal@none@1@S@Nucleotide sequence and PCR analyses demonstrated the presence of novel duplications or deletions involving the NF-kappa B motif.@(((:tag . "NNP") (:stem . "Nucleotide") (:form . "Nucleotide") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pcr") (:form . "PCR") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "duplication") (:form . "duplications") (:end . 84)\n  (:start . 72) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 120)\n  (:start . 112) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x9.4.1) (:span 85 87)))\n (:hscopes ((:id . :x9.4.1) (:span 66 128)))\n (:identifiers (:sid . :s9.4) (:did . :|91134976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000071@unknown@formal@none@1@S@These changes in the enhancer element were identified in the original AL1 virus stock.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "al1") (:form . "AL1") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stock") (:form . "stock") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s9.5) (:did . :|91134976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000072@unknown@formal@none@1@S@Subcloning of the variant NF-kappa B segments into LTR-driven CAT expression vectors confirmed a correlation between promoter activity and replicative/cytopathic capacity.@(((:tag . "NN") (:stem . "subcloning") (:form . "Subcloning") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ltr-driven") (:form . "LTR-driven") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "replicative/cytopathic")\n  (:form . "replicative/cytopathic") (:end . 161) (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 170)\n  (:start . 162) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s9.6) (:did . :|91134976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000073@unknown@formal@none@1@S@1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.@(((:tag . "NNP") (:stem . "1,25-Dihydroxyvitamin")\n  (:form . "1,25-Dihydroxyvitamin") (:end . 21) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 24) (:start . 22)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 44))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 37) (:start . 34)\n  (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s10.1) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000074@unknown@formal@none@1@S@1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] induces differentiation and inhibits proliferation of myeloid leukemic cells from various lines and patients;@(((:tag . "NNP") (:stem . "1,25-Dihydroxyvitamin")\n  (:form . "1,25-Dihydroxyvitamin") (:end . 21) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 24) (:start . 22)\n  (:id . 43))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 26) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 62) (:start . 47) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 100)\n  (:start . 93) (:id . 53))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 134)\n  (:start . 129) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 147)\n  (:start . 139) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 148) (:start . 147)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s10.2) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000075@unknown@formal@none@1@S@these effects are probably mediated through the 1,25(OH)2D3 receptor.@(((:tag . "DT") (:stem . "these") (:form . "these") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x10.3.1) (:span 18 26)))\n (:hscopes ((:id . :x10.3.1) (:span 18 68)))\n (:identifiers (:sid . :s10.3) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000076@unknown@formal@none@1@S@Little is known of expression of 1,25(OH)2D3 receptor RNA in hematopoietic cells.@(((:tag . "JJ") (:stem . "little") (:form . "Little") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 74) (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s10.4) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000077@unknown@formal@none@1@S@We examined the expression and modulation of expression of 1,25(OH)2D3 receptor RNA in various proliferating and nonproliferating hematopoietic cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "VBG") (:stem . "proliferate") (:form . "proliferating")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonproliferating") (:form . "nonproliferating")\n  (:end . 129) (:start . 113) (:id . 58))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 143) (:start . 130) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s10.5) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000078@unknown@formal@none@1@S@Constitutive expression of 1,25(OH)2D3 receptor RNA was detected in various kinds of hematopoietic cells, including macrophages and activated T lymphocytes, as well as in cell lines KG-1 (myeloblasts), HL-60 (promyelocytes), ML-3 (myelomonoblasts), U937, THP-1 (monoblasts), K562 (erythroblasts), and S-LB1 (HTLV-1-transfected T lymphocytes).@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 38)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "VBD") (:stem . 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")") (:end . 223) (:start . 222)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 224) (:start . 223)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "ML-3") (:form . "ML-3") (:end . 229) (:start . 225)\n  (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "myelomonoblast") (:form . "myelomonoblasts")\n  (:end . 246) (:start . 231) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 247) (:start . 246)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 248) (:start . 247)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 253) (:start . 249)\n  (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 254) (:start . 253)\n  (:id . 86))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 260)\n  (:start . 255) (:id . 87))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 262) (:start . 261)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "monoblast") (:form . "monoblasts") (:end . 272)\n  (:start . 262) (:id . 89))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 273) (:start . 272)\n  (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 274) (:start . 273)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "K562") (:form . "K562") (:end . 279) (:start . 275)\n  (:id . 92))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 281) (:start . 280)\n  (:id . 93))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 294) (:start . 281) (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 295) (:start . 294)\n  (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 296) (:start . 295)\n  (:id . 96))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 300) (:start . 297)\n  (:id . 97))\n ((:tag . "NN") (:stem . "s-lb1") (:form . "S-LB1") (:end . 306)\n  (:start . 301) (:id . 98))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 308) (:start . 307)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "htlv-1-transfected") (:form . "HTLV-1-transfected")\n  (:end . 326) (:start . 308) (:id . 100))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 328) (:start . 327)\n  (:id . 101))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 340)\n  (:start . 329) (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 341) (:start . 340)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 342) (:start . 341)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s10.6) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000080@unknown@formal@none@1@S@All cell lines examined in this group also expressed 1,25(OH)2D3 receptors.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s10.8) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000081@unknown@formal@none@1@S@Most B lymphocyte lines expressed negligible levels of 1,25(OH)2D3 receptor RNA and protein; however ; analysis of a lymphoid/myeloid somatic hybrid suggested that suppression of expression of 1,25(OH)2D3 receptor RNA in B lymphocytes may be a dominant characteristic.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "negligible") (:form . "negligible") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoid/myeloid") (:form . "lymphoid/myeloid")\n  (:end . 133) (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "somatic") (:form . "somatic") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 163) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 175)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 189)\n  (:start . 179) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 204)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 213)\n  (:start . 205) (:id . 71))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 217) (:start . 214)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 222) (:start . 221)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 234)\n  (:start . 223) (:id . 75))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 238) (:start . 235)\n  (:id . 76))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 241) (:start . 239)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 243) (:start . 242)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 252)\n  (:start . 244) (:id . 79))\n ((:tag . "NN") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 267) (:start . 253) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x10.9.1) (:span 235 238))\n  ((:id . :x10.9.2) (:span 149 158)))\n (:hscopes ((:id . :x10.9.1) (:span 235 267))\n  ((:id . :x10.9.2) (:span 149 267)))\n (:identifiers (:sid . :s10.9) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000082@unknown@formal@none@1@S@HL-60 cells were cultured with 10(-7) mol/L 1,25(OH)2D3 for 24 to 72 hours, and levels of expression of 1,25(OH)2D3 receptor and its RNA were examined.@(((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "10(-7)") (:form . "10(-7)") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s10.10) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000083@unknown@formal@none@1@S@Levels of RNA coding for the receptor were not modulated by exposure to high levels of ligand.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x10.11.1) (:span 43 46)))\n (:nscopes ((:id . :x10.11.1) (:span 0 93)))\n (:identifiers (:sid . :s10.11) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000084@unknown@formal@none@1@S@Levels of occupied 1,25(OH)2D3 receptor protein increased in these HL-60 cells; but the total number of 1,25(OH)2D3 receptors decreased about 50% at 24 hours and returned toward normal at 72 hours.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 177)\n  (:start . 171) (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 184)\n  (:start . 178) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s10.12) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000085@unknown@formal@none@1@S@Steady-state levels of 1,25(OH)2D3 receptor RNA were not affected by terminal differentiation of HL-60 toward either granulocytes or macrophages.@(((:tag . "JJ") (:stem . "steady-state") (:form . "Steady-state") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 19)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 93) (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 129)\n  (:start . 117) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 144)\n  (:start . 133) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x10.13.1) (:span 53 56)))\n (:nscopes ((:id . :x10.13.1) (:span 0 144)))\n (:identifiers (:sid . :s10.13) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000086@unknown@formal@none@1@S@Nondividing macrophages from normal individuals also expressed 1,25(OH)2D3 receptor RNA.@(((:tag . "VBG") (:stem . "nondivide") (:form . "Nondividing") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 74)\n  (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 83)\n  (:start . 75) (:id . 50))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 87) (:start . 84)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s10.14) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000087@unknown@formal@none@1@S@In contrast, nondividing peripheral blood lymphocytes from normal individuals did not express 1,25(OH)2D3 receptor RNA;@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nondividing") (:form . "nondividing") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 114)\n  (:start . 106) (:id . 56))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x10.15.1) (:span 82 85)))\n (:nscopes ((:id . :x10.15.1) (:span 82 118)))\n (:identifiers (:sid . :s10.15) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000088@unknown@formal@none@1@S@with stimulation of proliferation of these cells, accumulation of 1,25(OH)2D3 receptor RNA increased markedly.@(((:tag . "IN") (:stem . "with") (:form . "with") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s10.16) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000090@unknown@formal@none@1@S@Consistent with this short t1/2, accumulation of 1,25(OH)2D3 receptor RNA increased in cells as their protein synthesis was inhibited.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t1/2") (:form . "t1/2") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 101)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 133)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s10.18) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000091@unknown@formal@none@1@S@Further studies are required to understand the physiologic role of 1,25(OH)2D3 receptors in myeloid cells and proliferating T lymphocytes.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "proliferate") (:form . "proliferating")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 137)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s10.19) (:did . :|91159628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000092@unknown@formal@none@1@S@Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line.@(((:tag . "NNP") (:stem . "Kappa") (:form . "Kappa") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 43) (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s11.1) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000093@unknown@formal@none@1@S@The IL-2 and the IL-2-R alpha genes are both expressed transiently in normal T lymphocytes after Ag or mitogen activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2-R") (:form . "IL-2-R") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s11.2) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000094@unknown@formal@none@1@S@In contrast, the human T cell line, IARC 301, expresses these two genes constitutively and we have previously demonstrated that its growth depends on the autocrine production of this T cell growth factor and high affinity IL-2R.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 40) (:start . 36)\n  (:id . 51))\n ((:tag . "CD") (:stem . "301") (:form . "301") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 55)\n  (:start . 46) (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 61) (:start . 56)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 86) (:start . 72) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 109)\n  (:start . 99) (:id . 62))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 122)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 138)\n  (:start . 132) (:id . 66))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 163)\n  (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 174)\n  (:start . 164) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 184) (:start . 183)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 196)\n  (:start . 190) (:id . 76))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 203)\n  (:start . 197) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 212) (:start . 208)\n  (:id . 79))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 221)\n  (:start . 213) (:id . 80))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 227)\n  (:start . 222) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s11.3) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000095@unknown@formal@none@1@S@To dissect the molecular basis for the unusual persistent expression of the IL-2 and IL-2-R alpha genes in these IARC 301 T cells, we have analyzed the interactions of constitutively expressed nuclear proteins with the 5' flanking regions of the IL-2 and IL-2-R alpha genes using both DNase I footprinting and gel retardation techniques.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "dissect") (:form . "dissect") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"genes") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "CD") (:stem . "301") (:form . "301") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 138) (:start . 134)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 147)\n  (:start . 139) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 164)\n  (:start . 152) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 182) (:start . 168) (:id . 72))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 192)\n  (:start . 183) (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 200)\n  (:start . 193) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 77))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 220) (:start . 219)\n  (:id . 78))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 221) (:start . 220)\n  (:id . 79))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 230)\n  (:start . 222) (:id . 80))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 238)\n  (:start . 231) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 83))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 250) (:start . 246)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 254) (:start . 251)\n  (:id . 85))\n ((:tag . "NN") (:stem . "il-2-r") (:form . "IL-2-R") (:end . 261)\n  (:start . 255) (:id . 86))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 267)\n  (:start . 262) (:id . 87))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 273)\n  (:start . 268) (:id . 88))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 279) (:start . 274)\n  (:id . 89))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 284) (:start . 280)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 290)\n  (:start . 285) (:id . 91))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 292) (:start . 291)\n  (:id . 92))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 305)\n  (:start . 293) (:id . 93))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 309) (:start . 306)\n  (:id . 94))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 313) (:start . 310)\n  (:id . 95))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 325)\n  (:start . 314) (:id . 96))\n ((:tag . "NNS") (:stem . "technique") (:form . "techniques") (:end . 336)\n  (:start . 326) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5000096@unknown@formal@none@1@S@We have found that a region in both genes (-276 to -250 for IL-2-R alpha and -203 to -183 for IL-2), which corresponds to a kappa B enhancer element, is specifically protected by nuclear proteins from IARC 301.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-276") (:form . "-276") (:end . 47) (:start . 43)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 53))\n ((:tag . "CD") (:stem . "-250") (:form . "-250") (:end . 55) (:start . 51)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2-R") (:form . "IL-2-R") (:end . 66)\n  (:start . 60) (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 72) (:start . 67)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-203") (:form . "-203") (:end . 81) (:start . 77)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-183") (:form . "-183") (:end . 89) (:start . 85)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 98) (:start . 94)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 66))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 118)\n  (:start . 107) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 129)\n  (:start . 124) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 131) (:start . 130)\n  (:id . 71))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 140)\n  (:start . 132) (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 148)\n  (:start . 141) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 75))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 165)\n  (:start . 153) (:id . 76))\n ((:tag . "VBN") (:stem . "protect") (:form . "protected") (:end . 175)\n  (:start . 166) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 186)\n  (:start . 179) (:id . 79))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 195)\n  (:start . 187) (:id . 80))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 200) (:start . 196)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 205) (:start . 201)\n  (:id . 82))\n ((:tag . "CD") (:stem . "301") (:form . "301") (:end . 209) (:start . 206)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s11.5) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000097@unknown@formal@none@1@S@In agreement with this finding, both the IL-2 and IL-2-R alpha promoters are active in transient transfection assays in IARC 301 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2-r") (:form . "IL-2-R") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "CD") (:stem . "301") (:form . "301") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s11.6) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000098@unknown@formal@none@1@S@In contrast, mutation of the kappa B enhancer results in markedly attenuated activities of both promoters.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s11.7) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000100@unknown@formal@none@1@S@They bind to the kappa B motifs with different relative affinities that may reflect their different contribution in the expression of various promoters.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 89)\n  (:start . 84) (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 112)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x11.9.1) (:span 72 75)))\n (:hscopes ((:id . :x11.9.1) (:span 72 151)))\n (:identifiers (:sid . :s11.9) (:did . :|91170801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000101@unknown@formal@none@1@S@The functional domains of the murine Thy-1 gene promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "thy-1") (:form . "Thy-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s12.1) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000102@unknown@formal@none@1@S@The Thy-1 gene promoter resembles a " housekeeping " promoter in that it is located within a methylation-free island, lacks a canonical TATA box, and displays heterogeneity in the 5'-end termini of the mRNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thy-1") (:form . "Thy-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "resemble") (:form . "resembles") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "housekeeping") (:form . "housekeeping") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "methylation-free") (:form . "methylation-free")\n  (:end . 109) (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 158)\n  (:start . 150) (:id . 69))\n ((:tag . "NN") (:stem . "heterogeneity") (:form . "heterogeneity")\n  (:end . 172) (:start . 159) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "5'-end") (:form . "5'-end") (:end . 186)\n  (:start . 180) (:id . 73))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 194)\n  (:start . 187) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 206) (:start . 202)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x12.2.1) (:span 118 123)))\n (:nscopes ((:id . :x12.2.1) (:span 118 144)))\n (:identifiers (:sid . :s12.2) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000103@unknown@formal@none@1@S@Using transgenic mice, we show that this promoter does not confer any tissue specificity and is active only in a position-dependent manner.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "position-dependent") (:form . "position-dependent")\n  (:end . 131) (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 138)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x12.3.1) (:span 55 58)))\n (:nscopes ((:id . :x12.3.1) (:span 55 88)))\n (:identifiers (:sid . :s12.3) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000104@unknown@formal@none@1@S@It can only be activated in a tissue-specific manner by elements that lie downstream of the initiation site.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 45) (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "lie") (:form . "lie") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s12.4) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000105@unknown@formal@none@1@S@We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the transcription factor Sp1, an inverted CCAAT box, and sequences proximal to the transcription start site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "thy-1") (:form . "Thy-1") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "VBP") (:stem . "consist") (:form . "consist") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 170) (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "invert") (:form . "inverted") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "ccaat") (:form . "CCAAT") (:end . 200)\n  (:start . 195) (:id . 73))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 219)\n  (:start . 210) (:id . 77))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 228)\n  (:start . 220) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 231) (:start . 229)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 249) (:start . 236) (:id . 81))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 255)\n  (:start . 250) (:id . 82))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 260) (:start . 256)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s12.5) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000106@unknown@formal@none@1@S@DNase I and gel mobility shift assays show the binding of a number of nuclear factors to these elements, including Sp1 and CP1.@(((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 114)\n  (:start . 105) (:id . 62))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CP1") (:form . "CP1") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s12.6) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000107@unknown@formal@none@1@S@Our results show that the structure of this promoter only permits productive interactions of the two transcription factors Sp1 and CP1 with the basal transcription machinery in the presence of enhancer sequences.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "permit") (:form . "permits") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cp1") (:form . "CP1") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 163) (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 189)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 71))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 201)\n  (:start . 193) (:id . 72))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 211)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s12.7) (:did . :|91172211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000108@unknown@formal@none@1@S@Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 56) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 68)\n  (:start . 57) (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 77)\n  (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 86) (:start . 81)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 106)\n  (:start . 97) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 107) (:start . 106)\n  (:id . 54))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 118)\n  (:start . 108) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 157)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 166)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 188) (:start . 184)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s13.1) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000110@unknown@formal@none@1@S@A factor with apparently indistinguishable sequence specificity can be induced in many other cell types, where it is used to regulate inducible gene expression.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 42) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s13.3) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000111@unknown@formal@none@1@S@For example, kappa B-related sequences have been shown to be important for the transcription of a few inducible genes, such as the interleukin 2 receptor alpha-chain gene and the beta-interferon gene.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 142)\n  (:start . 131) (:id . 66))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 153)\n  (:start . 145) (:id . 68))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 165)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "NN") (:stem . "beta-interferon") (:form . "beta-interferon")\n  (:end . 194) (:start . 179) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 199) (:start . 195)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s13.4) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000112@unknown@formal@none@1@S@However, these genes are not constitutively active in B lymphocytes, suggesting that other regulatory mechanisms must play a role in determining the patterns of expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 43) (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 144)\n  (:start . 133) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x13.5.1) (:span 69 79)))\n (:ncues ((:id . :x13.5.2) (:span 25 28)))\n (:hscopes ((:id . :x13.5.1) (:span 69 171)))\n (:nscopes ((:id . :x13.5.2) (:span 25 67)))\n (:identifiers (:sid . :s13.5) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000113@unknown@formal@none@1@S@We have investigated the constitutive and inducible transcriptional activity mediated by five kappa B-related sequence elements in two different cell types.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 85)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 93) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 118)\n  (:start . 110) (:id . 56))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 127)\n  (:start . 119) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 144)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s13.6) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000114@unknown@formal@none@1@S@We show that in S194 plasma cells the activity of each element correlates well with the relative affinity of B-cell-derived NF-kappa B for that element.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "s194") (:form . "S194") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "b-cell-derived") (:form . "B-cell-derived")\n  (:end . 123) (:start . 109) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s13.7) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000115@unknown@formal@none@1@S@This leads to significantly lower transcription enhancement by sites derived from the interleukin 2 receptor or T-cell receptor genes in S194 cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 97)\n  (:start . 86) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "s194") (:form . "S194") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s13.8) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000116@unknown@formal@none@1@S@However, in either EL-4 ( T ) cells or S194 cells, both lower-affinity sites can be significantly induced by the tax gene product of human T-cell leukemia virus type I, showing that NF-kappa B activity can be modulated even in a B-cell line that constitutively expresses this factor.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 38) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "s194") (:form . "S194") (:end . 43) (:start . 39)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lower-affinity") (:form . "lower-affinity")\n  (:end . 70) (:start . 56) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 76) (:start . 71)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 83) (:start . 81)\n  (:id . 59))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 97) (:start . 84) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 105)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 121) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 129)\n  (:start . 122) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 145)\n  (:start . 139) (:id . 69))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 154)\n  (:start . 146) (:id . 70))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 167) (:start . 166)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 176)\n  (:start . 169) (:id . 75))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 181) (:start . 177)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 190)\n  (:start . 182) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 192) (:start . 191)\n  (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 201)\n  (:start . 193) (:id . 79))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 205) (:start . 202)\n  (:id . 80))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 208) (:start . 206)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 218)\n  (:start . 209) (:id . 82))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 223) (:start . 219)\n  (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 228) (:start . 227)\n  (:id . 85))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 235)\n  (:start . 229) (:id . 86))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 240) (:start . 236)\n  (:id . 87))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 245) (:start . 241)\n  (:id . 88))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 260) (:start . 246) (:id . 89))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 270)\n  (:start . 261) (:id . 90))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 275) (:start . 271)\n  (:id . 91))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 282)\n  (:start . 276) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s13.9) (:did . :|91172768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000117@unknown@formal@none@1@S@Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B [published erratum appears in Science 1991 Oct 4 ; 254 ( 5028 ) : 11]@(((:tag . "NN") (:stem . "isolation") (:form . "Isolation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "rel-related") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "65-kd") (:form . "65-kD") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Science") (:form . "Science") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "CD") (:stem . "254") (:form . "254") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "CD") (:stem . "5028") (:form . "5028") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 163) (:start . 161)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 164) (:start . 163)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x14.1.1) (:span 43 54)))\n (:hscopes ((:id . :x14.1.1) (:span 43 94)))\n (:identifiers (:sid . :s14.1) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000118@unknown@formal@none@1@S@A DNA probe that spanned a domain conserved among the proto-oncogene c-rel, the Drosophila morphogen dorsal, and the p50 DNA binding subunit of NF-kappa B was generated from Jurkat T cell complementary DNA with the polymerase chain reaction (PCR) and degenerate oligonucleotides.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "span") (:form . "spanned") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 68) (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "morphogen") (:form . "morphogen") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "dorsal") (:form . "dorsal") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 168)\n  (:start . 159) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 173) (:start . 169)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 180)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 182) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 201) (:start . 188) (:id . 75))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 210) (:start . 206)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 225)\n  (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 231)\n  (:start . 226) (:id . 80))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 240)\n  (:start . 232) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 242) (:start . 241)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 245) (:start . 242)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 246) (:start . 245)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 250) (:start . 247)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 261)\n  (:start . 251) (:id . 86))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 278) (:start . 262) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s14.2) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000120@unknown@formal@none@1@S@In vitro transcription and translation of the complementary DNA resulted in the synthesis of a protein with an apparent molecular size of 65 kilodaltons (kD).@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "kilodalton") (:form . "kilodaltons") (:end . 152)\n  (:start . 141) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s14.4) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000121@unknown@formal@none@1@S@The translated protein showed weak DNA binding with a specificity for the kappa B binding motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s14.5) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000122@unknown@formal@none@1@S@This protein-DNA complex comigrated with the complex obtained with the purified human p65 NF-kappa B subunit and binding was inhibited by I kappa B-alpha and -beta proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "comigrate") (:form . "comigrated") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s14.6) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000123@unknown@formal@none@1@S@In addition, the 65-kD protein associated with the p50 subunit of NF-kappa B and the kappa B probe to form a complex with the same electrophoretic mobility as the NF-kappa B-DNA complex.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "65-kd") (:form . "65-kD") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 116)\n  (:start . 109) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 130) (:start . 126)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 146) (:start . 131) (:id . 68))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 155)\n  (:start . 147) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 171)\n  (:start . 163) (:id . 72))\n ((:tag . "NNP") (:stem . "B-DNA") (:form . "B-DNA") (:end . 177)\n  (:start . 172) (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 185)\n  (:start . 178) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s14.7) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000124@unknown@formal@none@1@S@Therefore the rel-related 65-kD protein may represent the p65 subunit of the active NF-kappa B transcription factor complex.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "rel-related") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "65-kd") (:form . "65-kD") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x14.8.1) (:span 40 43)))\n (:hscopes ((:id . :x14.8.1) (:span 40 123)))\n (:identifiers (:sid . :s14.8) (:did . :|91173312|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000125@unknown@formal@none@1@S@Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder.@(((:tag . "NNP") (:stem . "Lymphocyte") (:form . "Lymphocyte") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 25) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 41)\n  (:start . 35) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "posttraumatic") (:form . "posttraumatic")\n  (:end . 58) (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 65)\n  (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s15.1) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000126@unknown@formal@none@1@S@OBJECTIVE: The authors ' objective was to investigate the possibility that glucocorticoid receptor changes may be involved in the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in posttraumatic stress disorder (PTSD).@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "objective") (:form . "objective") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 143) (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "hypothalamic-pituitary-adrenal")\n  (:form . "hypothalamic-pituitary-adrenal") (:end . 181) (:start . 151)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hpa") (:form . "HPA") (:end . 186) (:start . 183)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 68))\n ((:tag . "NN") (:stem . "axis") (:form . "axis") (:end . 192) (:start . 188)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "posttraumatic") (:form . "posttraumatic")\n  (:end . 209) (:start . 196) (:id . 71))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 216)\n  (:start . 210) (:id . 72))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 225)\n  (:start . 217) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 231) (:start . 227)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x15.2.1) (:span 107 110)) ((:id . :x15.2.2) (:span 58 69)))\n (:hscopes ((:id . :x15.2.1) (:span 75 232))\n  ((:id . :x15.2.2) (:span 58 232)))\n (:identifiers (:sid . :s15.2) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000127@unknown@formal@none@1@S@METHOD: They measured the number of lymphocyte cytosolic glucocorticoid receptors and plasma cortisol concentrations in 15 consecutively admitted male combat Vietnam veterans with PTSD and in a normal comparison group of 11 subjects.@(((:tag . "NN") (:stem . "method") (:form . "METHOD") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 71) (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 116) (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "RB") (:stem . "consecutively") (:form . "consecutively")\n  (:end . 136) (:start . 123) (:id . 59))\n ((:tag . "VBN") (:stem . "admit") (:form . "admitted") (:end . 145)\n  (:start . 137) (:id . 60))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 150) (:start . 146)\n  (:id . 61))\n ((:tag . "NN") (:stem . "combat") (:form . "combat") (:end . 157)\n  (:start . 151) (:id . 62))\n ((:tag . "NNP") (:stem . "Vietnam") (:form . "Vietnam") (:end . 165)\n  (:start . 158) (:id . 63))\n ((:tag . "NNS") (:stem . "veteran") (:form . "veterans") (:end . 174)\n  (:start . 166) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 184) (:start . 180)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 200)\n  (:start . 194) (:id . 70))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 211)\n  (:start . 201) (:id . 71))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 217)\n  (:start . 212) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 73))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 223) (:start . 221)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 232)\n  (:start . 224) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s15.3) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000128@unknown@formal@none@1@S@RESULTS: Both the patients and the normal comparison subjects showed a morning-to-afternoon decline in glucocorticoid receptor concentrations, paralleling the normal diurnal decline in cortisol levels.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 68) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "morning-to-afternoon")\n  (:form . "morning-to-afternoon") (:end . 91) (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 117) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 141) (:start . 127) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "parallel") (:form . "paralleling") (:end . 154)\n  (:start . 143) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 165)\n  (:start . 159) (:id . 63))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 173)\n  (:start . 166) (:id . 64))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 181)\n  (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 193)\n  (:start . 185) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 200)\n  (:start . 194) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s15.4) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000130@unknown@formal@none@1@S@No group differences in cortisol levels were observed, nor were glucocorticoid receptor number and cortisol levels correlated.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 78) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x15.6.1) (:span 55 58)) ((:id . :x15.6.2) (:span 0 2)))\n (:nscopes ((:id . :x15.6.1) (:span 55 125)) ((:id . :x15.6.2) (:span 0 53)))\n (:identifiers (:sid . :s15.6) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000131@unknown@formal@none@1@S@The number of morning glucocorticoid receptors was positively correlated with symptoms of PTSD and anxiety.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "morning") (:form . "morning") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 36) (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "anxiety") (:form . "anxiety") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s15.7) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000132@unknown@formal@none@1@S@CONCLUSIONS: These results provide further evidence for a dysregulation of the HPA axis in PTSD.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "These") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hpa") (:form . "HPA") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "axis") (:form . "axis") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s15.8) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000133@unknown@formal@none@1@S@The finding that patients with PTSD had a substantially greater number of lymphocyte glucocorticoid receptors than normal comparison subjects is consistent with the authors ' previous observations of low 24-hour urinary cortisol excretion in subjects with PTSD.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 99) (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 132)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 172)\n  (:start . 165) (:id . 65))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 174) (:start . 173)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 196)\n  (:start . 184) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "24-hour") (:form . "24-hour") (:end . 211)\n  (:start . 204) (:id . 71))\n ((:tag . "JJ") (:stem . "urinary") (:form . "urinary") (:end . 219)\n  (:start . 212) (:id . 72))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 228)\n  (:start . 220) (:id . 73))\n ((:tag . "NN") (:stem . "excretion") (:form . "excretion") (:end . 238)\n  (:start . 229) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 241) (:start . 239)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 250)\n  (:start . 242) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 255) (:start . 251)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 260) (:start . 256)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s15.9) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000134@unknown@formal@none@1@S@Furthermore, the receptor changes observed are opposite of those reported in major depressive disorder.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "depressive") (:form . "depressive") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s15.10) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000135@unknown@formal@none@1@S@The present data, along with other findings of HPA abnormalities in PTSD, support the possibility of a greater negative feedback sensitivity at one or more levels of the HPA axis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hpa") (:form . "HPA") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 64)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PTSD") (:form . "PTSD") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "feedback") (:form . "feedback") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 140)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "hpa") (:form . "HPA") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "NN") (:stem . "axis") (:form . "axis") (:end . 178) (:start . 174)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x15.11.1) (:span 86 97)))\n (:hscopes ((:id . :x15.11.1) (:span 86 178)))\n (:identifiers (:sid . :s15.11) (:did . :|91174087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000136@unknown@formal@none@1@S@A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "thymus-specific") (:form . "thymus-specific")\n  (:end . 17) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s16.1) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000137@unknown@formal@none@1@S@The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-specific activation of the T cell receptor ( TCR ) C alpha enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 98) (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 167)\n  (:start . 162) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "pyrimidine-rich") (:form . "pyrimidine-rich")\n  (:end . 186) (:start . 171) (:id . 72))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "5'-PyCTTTG-3") (:form . "5'-PyCTTTG-3")\n  (:end . 209) (:start . 197) (:id . 75))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 210) (:start . 209)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 211) (:start . 210)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 219)\n  (:start . 212) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 224) (:start . 223)\n  (:id . 80))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 232)\n  (:start . 225) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 241)\n  (:start . 236) (:id . 83))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 243) (:start . 242)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 257) (:start . 244) (:id . 85))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 265)\n  (:start . 258) (:id . 86))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 273)\n  (:start . 266) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s16.2) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000138@unknown@formal@none@1@S@Using amino acid sequence information derived from the DNA affinity-purified protein, we have now isolated cDNA clones encoding TCF-1 alpha.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "affinity-purified") (:form . "affinity-purified")\n  (:end . 76) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s16.3) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000140@unknown@formal@none@1@S@Expression of full-length and mutant cDNA clones in bacteria reveal that the single HMG motif, which is predicted to contain two extended alpha-helical segments, is sufficient to direct the sequence-specific binding of TCF-1 alpha to DNA.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 100)\n  (:start . 95) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "extended") (:form . "extended") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "JJ") (:stem . "alpha-helical") (:form . "alpha-helical")\n  (:end . 151) (:start . 138) (:id . 65))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 175)\n  (:start . 165) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 207) (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 215)\n  (:start . 208) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 230)\n  (:start . 225) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 237) (:start . 234)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x16.5.1) (:span 104 113)))\n (:hscopes ((:id . :x16.5.1) (:span 95 160)))\n (:identifiers (:sid . :s16.5) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000141@unknown@formal@none@1@S@Northern blot experiments demonstrate further that TCF-1 alpha mRNA is highly tissue specific, found primarily in the thymus or T cell lines.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 45)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s16.6) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000142@unknown@formal@none@1@S@The immature CEM T cell line expresses relatively low levels of TCF-1 alpha mRNA, which are increased upon activation of these cells by phorbol esters.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 150)\n  (:start . 144) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s16.7) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000143@unknown@formal@none@1@S@Interestingly, the cloned TCF-1 alpha protein is a potent transcriptional activator of the human TCR alpha enhancer in nonlymphoid cell lines, whereas the activity of the endogenous protein in T cell lines is strongly dependent on an additional T cell-specific protein that interacts with the core enhancer.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . 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"the") (:end . 292) (:start . 289)\n  (:id . 88))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 297) (:start . 293)\n  (:id . 89))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 306)\n  (:start . 298) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s16.8) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000144@unknown@formal@none@1@S@TCF-1 alpha is currently unique among the newly emerging family of DNA-binding regulatory proteins that share the HMG motif in that it is a highly tissue-specific RNA polymerase II transcription factor.@(((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "emerge") (:form . "emerging") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 162) (:start . 147) (:id . 67))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 177)\n  (:start . 167) (:id . 69))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 194) (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 201)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s16.9) (:did . :|91184620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000145@unknown@formal@none@1@S@Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus.@(((:tag . "JJ") (:stem . "immune") (:form . "Immune") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hbx-antigen") (:form . "HBx-antigen") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "hepatitis") (:form . "hepatitis") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s17.1) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000146@unknown@formal@none@1@S@The hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "hepatitis") (:form . "hepatitis") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 54) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 69) (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 88)\n  (:start . 78) (:id . 52))\n ((:tag . "NNP") (:stem . "HBxAg") (:form . "HBxAg") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s17.2) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000147@unknown@formal@none@1@S@We have investigated whether this antigen is a target structure for human T-lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x17.3.1) (:span 21 28)))\n (:hscopes ((:id . :x17.3.1) (:span 21 87)))\n (:identifiers (:sid . :s17.3) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000148@unknown@formal@none@1@S@Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patients with acute hepatitis B virus infection (6 of 6) and chronic hepatitis B virus infection (6 of 17) but not in healthy individuals.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "hbxag") (:form . "HBxAg") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hbxag-specific") (:form . "HBxAg-specific")\n  (:end . 56) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "NNP") (:stem . "hepatitis") (:form . "hepatitis") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 157)\n  (:start . 148) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 64))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 160) (:start . 159)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 178)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "hepatitis") (:form . "hepatitis") (:end . 188)\n  (:start . 179) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 206)\n  (:start . 197) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 75))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 209) (:start . 208)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 77))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 79))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 220) (:start . 217)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 224) (:start . 221)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 235)\n  (:start . 228) (:id . 83))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 247)\n  (:start . 236) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x17.4.1) (:span 221 224)))\n (:nscopes ((:id . :x17.4.1) (:span 221 247)))\n (:identifiers (:sid . :s17.4) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000150@unknown@formal@none@1@S@Most were located in the carboxyterminal half of the HBxAg protein.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "carboxyterminal") (:form . "carboxyterminal")\n  (:end . 40) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HBxAg") (:form . "HBxAg") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s17.6) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000151@unknown@formal@none@1@S@Five T-cell clones specific for a T-cell epitope located at the carboxyterminal region of HBxAg were established and found to belong to the CD2/CD4-positive, CD8-negative subtype.@(((:tag . "CD") (:stem . "five") (:form . "Five") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "carboxyterminal") (:form . "carboxyterminal")\n  (:end . 79) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HBxAg") (:form . "HBxAg") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "VB") (:stem . "belong") (:form . "belong") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cd2/cd4-positive") (:form . "CD2/CD4-positive")\n  (:end . 156) (:start . 140) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cd8-negative") (:form . "CD8-negative") (:end . 170)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "subtype") (:form . "subtype") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s17.7) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000152@unknown@formal@none@1@S@These data establish for the first time HBxAg as an antigen in the cellular immune response.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hbxag") (:form . "HBxAg") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s17.8) (:did . :|91184714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000153@unknown@formal@none@1@S@A study on the circadian rhythm of glucocorticoid receptor.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "rhythm") (:form . "rhythm") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 49) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s18.1) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000154@unknown@formal@none@1@S@Circadian rhythm in glucocorticoid receptor (GR) was studied in the rat liver and human peripheral leukocytes.@(((:tag . "JJ") (:stem . "circadian") (:form . "Circadian") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "rhythm") (:form . "rhythm") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s18.2) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000155@unknown@formal@none@1@S@For rats exposed to a natural environmental photic cycle or a 12L : 12D artificial light regime, peak values of hepatic GR were detected between 23:00 and 02:00 h.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "environmental") (:form . "environmental")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "photic") (:form . "photic") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "12l") (:form . "12L") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "12d") (:form . "12D") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "artificial") (:form . "artificial") (:end . 82)\n  (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regime") (:form . "regime") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "peak") (:form . "peak") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 108)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 144)\n  (:start . 137) (:id . 67))\n ((:tag . "CD") (:stem . "23:00") (:form . "23:00") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "CD") (:stem . "02:00") (:form . "02:00") (:end . 160)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 162) (:start . 161)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s18.3) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000156@unknown@formal@none@1@S@Except for a 4-hour advancement of the peak, a similar circadian rhythm of hepatic GR was detected in rats reared under a reversed lighting regimen (12D : 12L; lights on between 18:30 and 06:30 h).@(((:tag . "IN") (:stem . "except") (:form . "Except") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "4-hour") (:form . "4-hour") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "advancement") (:form . "advancement") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "rhythm") (:form . "rhythm") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "rear") (:form . "reared") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "lighting") (:form . "lighting") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "regimen") (:form . "regimen") (:end . 147)\n  (:start . 140) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "12d") (:form . "12D") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 154) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "12l") (:form . "12L") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 159) (:start . 158)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "light") (:form . "lights") (:end . 166)\n  (:start . 160) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 169) (:start . 167)\n  (:id . 74))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 177)\n  (:start . 170) (:id . 75))\n ((:tag . "CD") (:stem . "18:30") (:form . "18:30") (:end . 183)\n  (:start . 178) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 77))\n ((:tag . "CD") (:stem . "06:30") (:form . "06:30") (:end . 193)\n  (:start . 188) (:id . 78))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 195) (:start . 194)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s18.4) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000157@unknown@formal@none@1@S@In human leukocytes, the peak value of GR was found to parallel that of plasma cortisol with high and low values detected at 04:00-08:00 h and 23:00-24:00 h, respectively.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peak") (:form . "peak") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "VB") (:stem . "parallel") (:form . "parallel") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 78)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 112)\n  (:start . 106) (:id . 63))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 121)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "CD") (:stem . "04:00-08:00") (:form . "04:00-08:00") (:end . 136)\n  (:start . 125) (:id . 66))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "CD") (:stem . "23:00-24:00") (:form . "23:00-24:00") (:end . 154)\n  (:start . 143) (:id . 69))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 71))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 170)\n  (:start . 158) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s18.5) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000158@unknown@formal@none@1@S@In patients suffering from Cushing 's syndrome, the circadian rhythm of plasma cortisol either disappeared or was inverted while that of GR did not significantly deviate from the normal subjects.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBG") (:stem . "suffer") (:form . "suffering") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "rhythm") (:form . "rhythm") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "VBD") (:stem . "disappear") (:form . "disappeared") (:end . 106)\n  (:start . 95) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "invert") (:form . "inverted") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 161) (:start . 148) (:id . 67))\n ((:tag . "VB") (:stem . "deviate") (:form . "deviate") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x18.6.1) (:span 88 94 107 109)))\n (:hscopes ((:id . :x18.6.1) (:span 88 122)))\n (:identifiers (:sid . :s18.6) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000160@unknown@formal@none@1@S@Conversely, diurnal rhythmicity persisted in apoplexy patients whose lesions were in the cerebral cortex.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "rhythmicity") (:form . "rhythmicity") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "persist") (:form . "persisted") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "apoplexy") (:form . "apoplexy") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cerebral") (:form . "cerebral") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s18.8) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000161@unknown@formal@none@1@S@Thus, we postulated that the circadian modification of GR was independent of the diurnal fluctuations in plasma cortisol level or the circadian variations in environmental lighting and that the rhythmicity might be regulated by the ' circadian pacemaker ' located in the human basal brain.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "postulate") (:form . "postulated") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "fluctuation") (:form . "fluctuations") (:end . 101)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "variation") (:form . "variations") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "environmental") (:form . "environmental")\n  (:end . 171) (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "lighting") (:form . "lighting") (:end . 180)\n  (:start . 172) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 71))\n ((:tag . "NN") (:stem . "rhythmicity") (:form . "rhythmicity") (:end . 205)\n  (:start . 194) (:id . 72))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 211)\n  (:start . 206) (:id . 73))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 214) (:start . 212)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 224)\n  (:start . 215) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 77))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 233) (:start . 232)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "circadian") (:form . "circadian") (:end . 243)\n  (:start . 234) (:id . 79))\n ((:tag . "NN") (:stem . "pacemaker") (:form . "pacemaker") (:end . 253)\n  (:start . 244) (:id . 80))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 255) (:start . 254)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 263)\n  (:start . 256) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 266) (:start . 264)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 270) (:start . 267)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 276)\n  (:start . 271) (:id . 85))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 282)\n  (:start . 277) (:id . 86))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 288)\n  (:start . 283) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x18.9.1) (:span 206 211)) ((:id . :x18.9.2) (:span 127 129))\n  ((:id . :x18.9.3) (:span 9 19)))\n (:hscopes ((:id . :x18.9.1) (:span 190 288))\n  ((:id . :x18.9.2) (:span 77 180)) ((:id . :x18.9.3) (:span 9 288)))\n (:identifiers (:sid . :s18.9) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000162@unknown@formal@none@1@S@These diurnal variations in GR might serve to coordinate the reactivity of the target cells to cortisol because the diurnal rhythms of a GR-mediated response, the fractional inhibition of chemotactic migration rate of polymorphonuclear leukocytes by cortisol, were found to be synchronous with those of GR.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "variation") (:form . "variations") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "coordinate") (:form . "coordinate") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "rhythm") (:form . "rhythms") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "gr-mediated") (:form . "GR-mediated") (:end . 148)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "fractional") (:form . "fractional") (:end . 173)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 184)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 199)\n  (:start . 188) (:id . 72))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 209)\n  (:start . 200) (:id . 73))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 214) (:start . 210)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 235) (:start . 218) (:id . 76))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 246)\n  (:start . 236) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 249) (:start . 247)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 258)\n  (:start . 250) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 259) (:start . 258)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 264) (:start . 260)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 270)\n  (:start . 265) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 273) (:start . 271)\n  (:id . 83))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 276) (:start . 274)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "synchronous") (:form . "synchronous") (:end . 288)\n  (:start . 277) (:id . 85))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 293) (:start . 289)\n  (:id . 86))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 299)\n  (:start . 294) (:id . 87))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 302) (:start . 300)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 305) (:start . 303)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x18.10.1) (:span 31 36)))\n (:hscopes ((:id . :x18.10.1) (:span 31 103)))\n (:identifiers (:sid . :s18.10) (:did . :|91187152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000163@unknown@formal@none@1@S@Multiple Oct2 isoforms are generated by alternative splicing.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s19.1) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000164@unknown@formal@none@1@S@The interaction of the Oct2 transcription factor with the cognate octamer motif ATGCAAAT is a critical determinant of the lymphoid-specific expression of immunoglobulin genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ATGCAAAT") (:form . "ATGCAAAT") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 139) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 168) (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s19.2) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000165@unknown@formal@none@1@S@Ectopic expression of cloned Oct2 cDNA was shown to be sufficient to reconstitute at least some aspects of this regulation in non-lymphoid cells.@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "Oct2") (:form . "Oct2") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "reconstitute") (:form . "reconstitute") (:end . 81)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "non-lymphoid") (:form . "non-lymphoid") (:end . 138)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s19.3) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000166@unknown@formal@none@1@S@We describe the isolation and characterization of multiple cDNAs encoding mouse Oct2 from a mature B-cell line and we show that a variety of isoforms of this transcription factor is generated from a single gene by an alternative splicing mechanism.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 46) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 171) (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 196) (:start . 192)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 198) (:start . 197)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 205)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 210) (:start . 206)\n  (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 213) (:start . 211)\n  (:id . 77))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 216) (:start . 214)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 228)\n  (:start . 217) (:id . 79))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 237)\n  (:start . 229) (:id . 80))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 247)\n  (:start . 238) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s19.4) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000167@unknown@formal@none@1@S@All the isoforms retain the previously characterized POU-domain and are therefore able to bind to the octamer motif.@(((:tag . "PDT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "retain") (:form . "retain") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "POU-domain") (:form . "POU-domain") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s19.5) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000168@unknown@formal@none@1@S@Different amounts of the various isoforms are present within the same B-cell regardless of the developmental stage of B-cell differentiation and at least some of the isoforms are conserved between mouse and humans.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 108) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 140) (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 188)\n  (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 196)\n  (:start . 189) (:id . 71))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 202)\n  (:start . 197) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 213)\n  (:start . 207) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s19.6) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000170@unknown@formal@none@1@S@Finally, we show that one of the isoforms encodes the previously described lymphoid-specific Oct2B protein which has been suggested to be involved in the function of the octamer motif in the context of the immunoglobulin heavy-chain (IgH) enhancer.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 41)\n  (:start . 33) (:id . 50))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 92) (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "Oct2B") (:form . "Oct2B") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 162)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 198)\n  (:start . 191) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 220) (:start . 206) (:id . 77))\n ((:tag . "NN") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 232)\n  (:start . 221) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 234) (:start . 233)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 237) (:start . 234)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 238) (:start . 237)\n  (:id . 81))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 247)\n  (:start . 239) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x19.8.1) (:span 122 131)))\n (:hscopes ((:id . :x19.8.1) (:span 107 247)))\n (:identifiers (:sid . :s19.8) (:did . :|91187647|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000171@unknown@formal@none@1@S@Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.@(((:tag . "JJ") (:stem . "murine") (:form . "Murine") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 91) (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 99)\n  (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 106)\n  (:start . 100) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 123)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 138)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s20.1) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000172@unknown@formal@none@1@S@A family of transcriptional activators has recently been identified in chickens;@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "chicken") (:form . "chickens") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s20.2) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000173@unknown@formal@none@1@S@these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain.@(((:tag . "DT") (:stem . "these") (:form . "these") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 42)\n  (:start . 33) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 61)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "WGATAR") (:form . "WGATAR") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "c4") (:form . "C4") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 123)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s20.3) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000174@unknown@formal@none@1@S@One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "multigene") (:form . "multigene") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cgata-3") (:form . "cGATA-3") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 72)\n  (:start . 62) (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 102) (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s20.4) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000175@unknown@formal@none@1@S@Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 171)\n  (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s20.5) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000176@unknown@formal@none@1@S@The murine and human factors are abundantly expressed in a variety of human and murine T-cell lines and can activate transcription through a tissue-specific GATA-binding site identified within the human T-cell receptor delta gene enhancer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 156) (:start . 141) (:id . 65))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 169)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 185)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 192)\n  (:start . 186) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 202)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 209)\n  (:start . 203) (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 218)\n  (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 224)\n  (:start . 219) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 229) (:start . 225)\n  (:id . 75))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 238)\n  (:start . 230) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s20.6) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000177@unknown@formal@none@1@S@We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "infer") (:form . "infer") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 121) (:start . 106) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 137) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x20.7.1) (:span 3 8)))\n (:hscopes ((:id . :x20.7.1) (:span 3 148)))\n (:identifiers (:sid . :s20.7) (:did . :|91203899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000178@unknown@formal@none@1@S@Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection.@(((:tag . "NN") (:stem . "processing") (:form . "Processing") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s21.1) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000180@unknown@formal@none@1@S@T-cell activation also correlates with the induction of the factor NF-kappa B which binds to two adjacent sites in the HIV-1 long terminal repeat.@(((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s21.3) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000181@unknown@formal@none@1@S@This factor consists of two DNA-binding subunits of relative molecular mass 50,000 (50K) associated with two 65K subunits.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "50,000") (:form . "50,000") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "CD") (:stem . "50k") (:form . "50K") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "CD") (:stem . "65k") (:form . "65K") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s21.4) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000182@unknown@formal@none@1@S@It is located in the nucleus in mature B cells, but is present in other cell types as an inactive cytoplasmic complex.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 62)\n  (:start . 55) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 82) (:start . 77)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 88) (:start . 86)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 97)\n  (:start . 89) (:id . 62))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 109)\n  (:start . 98) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 117)\n  (:start . 110) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s21.5) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000183@unknown@formal@none@1@S@External stimuli, including those that activate T cells, result in nuclear translocation of active NF-kappa B.@(((:tag . "JJ") (:stem . "external") (:form . "External") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s21.6) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000184@unknown@formal@none@1@S@The cloning of the complementary DNA for the 50K subunit helped to identify an exclusively cytoplasmic 105K precursor (p105) (V.B., P.K. and A.I., manuscript submitted).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "50k") (:form . "50K") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "help") (:form . "helped") (:end . 63) (:start . 57)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "CD") (:stem . "105k") (:form . "105K") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "V.B.") (:form . "V.B.") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "P.K.") (:form . "P.K.") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "A.I.") (:form . "A.I.") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "manuscript") (:form . "manuscript") (:end . 157)\n  (:start . 147) (:id . 70))\n ((:tag . "VBN") (:stem . "submit") (:form . "submitted") (:end . 167)\n  (:start . 158) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s21.7) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000185@unknown@formal@none@1@S@The expression of active NF-kappa B might therefore also be regulated by the extent of processing of p105.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x21.8.1) (:span 36 41)))\n (:hscopes ((:id . :x21.8.1) (:span 0 105)))\n (:identifiers (:sid . :s21.8) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000186@unknown@formal@none@1@S@Because HIV-1 requires active NF-kappa B for efficient transcription, we tested the effect of HIV-1 infection on the processing of the human 105K precursor.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 79) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "CD") (:stem . "105k") (:form . "105K") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s21.9) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000187@unknown@formal@none@1@S@We show here that the HIV-1 protease can process p105 and increases levels of active nuclear NF-kappa B complex.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VB") (:stem . "process") (:form . "process") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s21.10) (:did . :|91204058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000188@unknown@formal@none@1@S@Vitamin D receptor expression in human lymphocytes.@(((:tag . "NNP") (:stem . "Vitamin") (:form . "Vitamin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s22.1) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000190@unknown@formal@none@1@S@The signals controlling the expression of the receptor protein for 1 alpha,25-dihydroxyvitamin D3 in normal human lymphocytes and the relationship of this protein to the classical vitamin D receptor were examined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha,25-dihydroxyvitamin")\n  (:form . "alpha,25-dihydroxyvitamin") (:end . 94) (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 146)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 179)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 198)\n  (:start . 190) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 203) (:start . 199)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 212)\n  (:start . 204) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s22.3) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000191@unknown@formal@none@1@S@Lymphocytes activated with the OKT3 antibody to the T-cell antigen receptor expressed fewer binding sites as compared to lymphocytes that were activated by the polyclonal activator phytohemagglutinin (PHA).@(((:tag . "NNS") (:stem . "lymphocyte") (:form . "Lymphocytes") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "okt3") (:form . "OKT3") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 132)\n  (:start . 121) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 180)\n  (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 199) (:start . 181) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 204) (:start . 201)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 205) (:start . 204)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s22.4) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000192@unknown@formal@none@1@S@However, combination of OKT3 and phorbol myristate acetate produced a concentration of binding sites similar to the PHA-activated cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "okt3") (:form . "OKT3") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 129) (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s22.5) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000193@unknown@formal@none@1@S@The receptor from OKT3 and OKT3 + phorbol myristate acetate-activated lymphocytes exhibited decreased binding to DNA-cellulose compared to PHA-activated lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "acetate-activated") (:form . "acetate-activated")\n  (:end . 69) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna-cellulose") (:form . "DNA-cellulose")\n  (:end . 126) (:start . 113) (:id . 57))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 135)\n  (:start . 127) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 152) (:start . 139) (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 164)\n  (:start . 153) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s22.6) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000194@unknown@formal@none@1@S@In lymphocytes activated either by PHA or OKT3 ( but not in resting cells), a 50-kDa species cross-reacting with a monoclonal antibody against the intestinal vitamin D receptor was detected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 84)\n  (:start . 78) (:id . 59))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 92)\n  (:start . 85) (:id . 60))\n ((:tag . "VBG") (:stem . "cross-reacte") (:form . "cross-reacting")\n  (:end . 107) (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 125)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 157)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 165)\n  (:start . 158) (:id . 69))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 176)\n  (:start . 168) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 180) (:start . 177)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 189)\n  (:start . 181) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x22.7.1) (:span 53 56)))\n (:nscopes ((:id . :x22.7.1) (:span 53 73)))\n (:identifiers (:sid . :s22.7) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000195@unknown@formal@none@1@S@Finally, RNA from activated lymphocytes was amplified by polymerase chain reaction using oligonucleotide primers flanking the 196 base pair long region encoding the DNA-binding domain of the human intestinal receptor.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 104) (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "CD") (:stem . "196") (:form . "196") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 151)\n  (:start . 145) (:id . 63))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 176)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 183)\n  (:start . 177) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 207)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 216)\n  (:start . 208) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s22.8) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000196@unknown@formal@none@1@S@The amplified product showed an identical nucleotide sequence to the DNA-binding domain of the human intestinal receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 28) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s22.9) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000197@unknown@formal@none@1@S@These findings suggest that expression of the 1,25-(OH)2D3 receptor in lymphocytes is triggered by distinct and contingent signals, and that the protein and the mRNA encoding it are identical to the classical vitamin D receptor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "contingent") (:form . "contingent") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 191)\n  (:start . 182) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 208)\n  (:start . 199) (:id . 74))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 227)\n  (:start . 219) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x22.10.1) (:span 15 22)))\n (:hscopes ((:id . :x22.10.1) (:span 15 227)))\n (:identifiers (:sid . :s22.10) (:did . :|91210272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000198@unknown@formal@none@1@S@Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.@(((:tag . "NN") (:stem . "cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 42) (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD3-epsilon") (:form . "CD3-epsilon") (:end . 117)\n  (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s23.1) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000200@unknown@formal@none@1@S@We have recently identified and cloned a human transcription factor, TCF-1, that binds to a functional element in the T lymphocyte-specific enhancer of CD3-epsilon.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 102)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 139) (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CD3-epsilon") (:form . "CD3-epsilon") (:end . 163)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s23.3) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000201@unknown@formal@none@1@S@In a panel of human cell lines, TCF-1 expression was restricted to T lineage cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s23.4) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000202@unknown@formal@none@1@S@TCF-1 belonged to a novel family of genes that contain the so-called high mobility group 1 ( HMG ) box.@(((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "belong") (:form . "belonged") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s23.5) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000203@unknown@formal@none@1@S@Here we report the cloning of murine TCF-1.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s23.6) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000204@unknown@formal@none@1@S@Two splice alternatives were identified that were not previously observed in human TCF-1.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "alternative") (:form . "alternatives") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x23.7.1) (:span 50 53)))\n (:nscopes ((:id . :x23.7.1) (:span 40 88)))\n (:identifiers (:sid . :s23.7) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000205@unknown@formal@none@1@S@Murine and human TCF-1 displayed a 95.5 % overall amino acid homology.@(((:tag . "JJ") (:stem . "murine") (:form . "Murine") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "95.5") (:form . "95.5") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s23.8) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000206@unknown@formal@none@1@S@Recombinant murine and human TCF-1 recognized the same sequence motif in the CD3-epsilon enhancer as judged by gel retardation and methylation interference assays.@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "recognize") (:form . "recognized") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD3-epsilon") (:form . "CD3-epsilon") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 126)\n  (:start . 115) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 142)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 155)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s23.9) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000207@unknown@formal@none@1@S@With the murine cDNA clones several aspects of TCF-1 were analyzed.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s23.10) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000208@unknown@formal@none@1@S@First, deletion analysis revealed that a region of TCF-1 containing the HMG box was sufficient for sequence-specific binding.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 116) (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s23.11) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000210@unknown@formal@none@1@S@Third, TCF-1 bound specifically to a functional T cell-specific element in the T cell receptor alpha (TCR-alpha) enhancer.@(((:tag . "RB") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TCR-alpha") (:form . "TCR-alpha") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s23.13) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000211@unknown@formal@none@1@S@The T lineage-specific expression and the affinity for functional motifs in the TCR-alpha and CD3-epsilon enhancers imply an important role for TCF-1 in the establishment of the mature T cell phenotype.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 22) (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TCR-alpha") (:form . "TCR-alpha") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD3-epsilon") (:form . "CD3-epsilon") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "establishment") (:form . "establishment")\n  (:end . 170) (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 184)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 191) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 201)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x23.14.1) (:span 116 121)))\n (:hscopes ((:id . :x23.14.1) (:span 116 201)))\n (:identifiers (:sid . :s23.14) (:did . :|91217625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000212@unknown@formal@none@1@S@HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes [see comments]@(((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "perpetuate") (:form . "perpetuated") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s24.1) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000213@unknown@formal@none@1@S@Permissiveness to replication of human immunodeficiency virus (HIV) differs in T lymphocytes and macrophages.@(((:tag . "NN") (:stem . "permissiveness") (:form . "Permissiveness")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 55) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 61) (:start . 56)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s24.2) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000214@unknown@formal@none@1@S@In T cells, HIV transcription is poorly detected in vivo.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s24.3) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000215@unknown@formal@none@1@S@Cloned, normal T lymphocytes show very little, if any, basal activity of the HIV enhancer and low nuclear expression of NF-kappa B, a potent transcriptional activator of the HIV enhancer.@(((:tag . "VBN") (:stem . "clone") (:form . "Cloned") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 89)\n  (:start . 81) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 105)\n  (:start . 98) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 140)\n  (:start . 134) (:id . 69))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 156) (:start . 141) (:id . 70))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 166)\n  (:start . 157) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 177) (:start . 174)\n  (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 186)\n  (:start . 178) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s24.4) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000216@unknown@formal@none@1@S@In contrast, fixed tissue macrophages express detectable HIV proteins, indicating permanent virus transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fixed") (:form . "fixed") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s24.5) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000217@unknown@formal@none@1@S@One explanation for the perpetuation of virus infection in macrophages could be sustained nuclear NF-kappa B expression.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "perpetuation") (:form . "perpetuation") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "sustain") (:form . "sustained") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x24.6.1) (:span 71 76)))\n (:hscopes ((:id . :x24.6.1) (:span 0 119)))\n (:identifiers (:sid . :s24.6) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000218@unknown@formal@none@1@S@However, the U937 monocytic cell line, which is fully permissive to HIV replication, is known to express only low levels of nuclear NF-kappa B.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 83)\n  (:start . 72) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 104)\n  (:start . 97) (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 120)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s24.7) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000220@unknown@formal@none@1@S@This phenomenon, which is independent of tumour necrosis factor, is associated with HIV replication, and is thus likely to explain at least in part the perpetuation of HIV infection in monocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "perpetuation") (:form . "perpetuation") (:end . 164)\n  (:start . 152) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 181)\n  (:start . 172) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 194)\n  (:start . 185) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x24.9.1) (:span 113 119)))\n (:hscopes ((:id . :x24.9.1) (:span 105 194)))\n (:identifiers (:sid . :s24.9) (:did . :|91218850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000221@unknown@formal@none@1@S@Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s25.1) (:did . :|91219488|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000222@unknown@formal@none@1@S@During latent Epstein-Barr virus (EBV) infection of human B lymphocytes, six viral nuclear antigen (EBNAs) are expressed from long primary transcripts by means of alternative splicing and alternative polyadenylylation sites.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "ebna") (:form . "EBNAs") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 120)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 138)\n  (:start . 131) (:id . 66))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 150)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 159)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 174)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 183)\n  (:start . 175) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 199)\n  (:start . 188) (:id . 74))\n ((:tag . "NN") (:stem . "polyadenylylation") (:form . "polyadenylylation")\n  (:end . 217) (:start . 200) (:id . 75))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 223)\n  (:start . 218) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s25.2) (:did . :|91219488|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000223@unknown@formal@none@1@S@These transcripts initiate from one of two promoters, Cp or Wp, that function in a mutually exclusive fashion.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "initiate") (:form . "initiate") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "RB") (:stem . "mutually") (:form . "mutually") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 101)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s25.3) (:did . :|91219488|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000224@unknown@formal@none@1@S@Wp is exclusively utilized during the initial stages of infection of primary B lymphocytes, followed by a switch to Cp usage.@(((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cp") (:form . "Cp") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s25.4) (:did . :|91219488|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000225@unknown@formal@none@1@S@These studies have been extended to show that ( i ) a mutant EBV strain lacking the gene encoding EBNA 2 fails to switch from Wp to Cp usage in primary B lymphocytes, although the virus contains a functional Cp; ( ii ) a region from -429 to -245 base pairs upstream of Cp is essential for Cp activity in B lymphocytes, but only in the context of upstream and downstream sequences; ( iii ) this region contains an EBNA 2-dependent enhancer; and ( iv ) DNase I protection employing nuclear extracts from B and T lymphocytes revealed a B-cell-specific footprint in the region of the EBNA 2-dependent enhancer.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . 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5000226@unknown@formal@none@1@S@These results support a model for viral promoter switching during the initial stages of infection in which Wp activity leads to the expression of EBNA 2, followed by activation of Cp through the EBNA 2-dependent enhancer.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 176)\n  (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 190)\n  (:start . 183) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 199) (:start . 195)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "2-dependent") (:form . "2-dependent") (:end . 211)\n  (:start . 200) (:id . 77))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 220)\n  (:start . 212) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s25.6) (:did . :|91219488|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000227@unknown@formal@none@1@S@Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid-resistant bronchial asthma.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 39) (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 52)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "corticosteroid-resistant")\n  (:form . "corticosteroid-resistant") (:end . 94) (:start . 70) (:id . 50))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 104)\n  (:start . 95) (:id . 51))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 111)\n  (:start . 105) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s26.1) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000228@unknown@formal@none@1@S@The mechanism of corticosteroid resistance in bronchial asthma has been studied by determining the rank order of potency for different corticosteroids in inhibiting the generation of a 3 kD molecule from peripheral blood monocytes isolated from corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic subjects, which augments leukotriene B4 (LTB4) generation by human neutrophils (PMN) stimulated by calcium ionophore.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . 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5000230@unknown@formal@none@1@S@The concentration of corticosteroid producing 50 % inhibition (IC50) was 600 nM, 70 nM, and 0.5 nM for hydrocortisone, methylprednisolone, and dexamethasone, respectively, in monocytes from CS individuals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IC50") (:form . "IC50") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "CD") (:stem . "600") (:form . "600") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 117) (:start . 103) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "methylprednisolone") (:form . "methylprednisolone")\n  (:end . 137) (:start . 119) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 156) (:start . 143) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 170)\n  (:start . 158) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 184)\n  (:start . 175) (:id . 74))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "cs") (:form . "CS") (:end . 192) (:start . 190)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 204)\n  (:start . 193) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s26.4) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000231@unknown@formal@none@1@S@There was only weak inhibition of the generation of enhancing activity by the corticosteroids in the CR asthmatic individuals.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancing") (:form . "enhancing") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cr") (:form . "CR") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s26.5) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000232@unknown@formal@none@1@S@The dexamethasone Kd was 2.45 ± 0.58 nM (mean ± SEM, n = 6) in the CS group and 1.6 ± 0.35 nM (mean ± SEM, n = 6) in the CR group of patients (p = 0.14).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "2.45") (:form . "2.45") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "±") (:form . "±") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "0.58") (:form . "0.58") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 54))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 54) (:start . 53)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 56) (:start . 55)\n  (:id . 56))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 58) (:start . 57)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cs") (:form . "CS") (:end . 69) (:start . 67)\n  (:id . 61))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 75) (:start . 70)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1.6") (:form . "1.6") (:end . 83) (:start . 80)\n  (:id . 64))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 85) (:start . 84)\n  (:id . 65))\n ((:tag . "CD") (:stem . "0.35") (:form . "0.35") (:end . 90) (:start . 86)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 93) (:start . 91)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 99) (:start . 95)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 101) (:start . 100)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 105) (:start . 102)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 72))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 108) (:start . 107)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 110) (:start . 109)\n  (:id . 74))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 112) (:start . 111)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "cr") (:form . "CR") (:end . 123) (:start . 121)\n  (:id . 79))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 129)\n  (:start . 124) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 141)\n  (:start . 133) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 83))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 144) (:start . 143)\n  (:id . 84))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 146) (:start . 145)\n  (:id . 85))\n ((:tag . "CD") (:stem . "0.14") (:form . "0.14") (:end . 151) (:start . 147)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s26.6) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000233@unknown@formal@none@1@S@The Ro in the CS group was 3,605 ± 984 binding sites per nucleus (mean ± SEM, n = 6) and 4,757 ± 692 binding sites per nucleus (mean ± SEM, n = 6) in the CR group (p = 0.23).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ro") (:form . "Ro") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CS") (:form . "CS") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3,605") (:form . "3,605") (:end . 32) (:start . 27)\n  (:id . 49))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "CD") (:stem . "984") (:form . "984") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 52) (:start . 47)\n  (:id . 53))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 64)\n  (:start . 57) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 70) (:start . 66)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 72) (:start . 71)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 76) (:start . 73)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 60))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 79) (:start . 78)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 81) (:start . 80)\n  (:id . 62))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 83) (:start . 82)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 65))\n ((:tag . "CD") (:stem . "4,757") (:form . "4,757") (:end . 94) (:start . 89)\n  (:id . 66))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 96) (:start . 95)\n  (:id . 67))\n ((:tag . "CD") (:stem . "692") (:form . "692") (:end . 100) (:start . 97)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 69))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 114)\n  (:start . 109) (:id . 70))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 118) (:start . 115)\n  (:id . 71))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 126)\n  (:start . 119) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 73))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 132) (:start . 128)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 134) (:start . 133)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 138) (:start . 135)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 77))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 141) (:start . 140)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 143) (:start . 142)\n  (:id . 79))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 145) (:start . 144)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "cr") (:form . "CR") (:end . 156) (:start . 154)\n  (:id . 84))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 162)\n  (:start . 157) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 86))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 165) (:start . 164)\n  (:id . 87))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 167) (:start . 166)\n  (:id . 88))\n ((:tag . "CD") (:stem . "0.23") (:form . "0.23") (:end . 172) (:start . 168)\n  (:id . 89))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s26.7) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000234@unknown@formal@none@1@S@These findings indicate that corticosteroid resistance in bronchial asthma can not be explained by abnormalities in corticosteroid receptor characteristics.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 43) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 54)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities")\n  (:end . 112) (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 130) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 139)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 155) (:start . 140) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x26.8.2) (:span 15 28)))\n (:ncues ((:id . :x26.8.1) (:span 75 82)))\n (:hscopes ((:id . :x26.8.2) (:span 15 155)))\n (:nscopes ((:id . :x26.8.1) (:span 29 155)))\n (:identifiers (:sid . :s26.8) (:did . :|91221358|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000235@unknown@formal@none@1@S@Tissue-specific expression of the platelet GPIIb gene.@(((:tag . "JJ") (:stem . "tissue-specific") (:form . "Tissue-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NNP") (:stem . "GPIIb") (:form . "GPIIb") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s27.1) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000236@unknown@formal@none@1@S@One of the major objectives in the study of thrombogenesis is to determine the mechanisms by which a hematopoietic progenitor is activated and committed to the megakaryocytic lineage.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "objective") (:form . "objectives") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "thrombogenesis") (:form . "thrombogenesis")\n  (:end . 58) (:start . 44) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 125)\n  (:start . 115) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "commit") (:form . "committed") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 174) (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 182)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s27.2) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000237@unknown@formal@none@1@S@Recent development of primary cultures of human megakaryocytes and the molecular cloning of genes that are specific to this lineage offer the possibility of getting some insights into the genetic mechanisms that control megakaryocytopoiesis.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 62) (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "VBP") (:stem . "offer") (:form . "offer") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 153)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "get") (:form . "getting") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 178)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 195)\n  (:start . 188) (:id . 71))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 206)\n  (:start . 196) (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 211) (:start . 207)\n  (:id . 73))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 219)\n  (:start . 212) (:id . 74))\n ((:tag . "NN") (:stem . "megakaryocytopoiesis")\n  (:form . "megakaryocytopoiesis") (:end . 240) (:start . 220) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s27.3) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000238@unknown@formal@none@1@S@One gene of interest is the glycoprotein IIb (GPIIb) gene;@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "IIb") (:form . "IIb") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GPIIb") (:form . "GPIIb") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 58) (:start . 57)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s27.4) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000240@unknown@formal@none@1@S@For these reasons, the 5'-flanking region of the GPIIb gene was used to identify the regions that interact with DNA-binding nuclear factors.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "reason") (:form . "reasons") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GPIIb") (:form . "GPIIb") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s27.6) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000241@unknown@formal@none@1@S@A fragment extending from -643 to +33 is capable of controlling the tissue-specific expression of the CAT gene in transfection experiments.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-643") (:form . "-643") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "+33") (:form . "+33") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 83) (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 126)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 138)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s27.7) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000242@unknown@formal@none@1@S@Within this region, we have identified several sequences that are implicated in DNA protein interactions as shown in DNAse I footprints and gel mobility shift assays.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 104)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DNAse") (:form . "DNAse") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "footprint") (:form . "footprints") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s27.8) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000243@unknown@formal@none@1@S@One region, centered at -54, is similar to a nuclear factor E1-binding site, and a region located at position -233 contains a CCAAT motif.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-54") (:form . "-54") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 39)\n  (:start . 32) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 52)\n  (:start . 45) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 54))\n ((:tag . "JJ") (:stem . "e1-binding") (:form . "E1-binding") (:end . 70)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 89)\n  (:start . 83) (:id . 60))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 97)\n  (:start . 90) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 109)\n  (:start . 101) (:id . 63))\n ((:tag . "CD") (:stem . "-233") (:form . "-233") (:end . 114) (:start . 110)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 123)\n  (:start . 115) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ccaat") (:form . "CCAAT") (:end . 131)\n  (:start . 126) (:id . 67))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s27.9) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000244@unknown@formal@none@1@S@Two domains centered at positions -345 and -540, respectively, bind proteins that are present in megakaryocytic cells and nonrelated cells as well.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "CD") (:stem . "-345") (:form . "-345") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "-540") (:form . "-540") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 111) (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nonrelated") (:form . "nonrelated") (:end . 132)\n  (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s27.10) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000245@unknown@formal@none@1@S@Finally, two other domains, located at positions -460 and -510, interact with proteins that are only present in megakaryocytic cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "CD") (:stem . "-460") (:form . "-460") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-510") (:form . "-510") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 126) (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s27.11) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000246@unknown@formal@none@1@S@In addition, deletion of the region containing these two domains results in a significant decrease of the promoter activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s27.12) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000247@unknown@formal@none@1@S@It is very likely that these domains bind megakaryocyte-specific nuclear proteins acting as positive transcription factors.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "megakaryocyte-specific")\n  (:form . "megakaryocyte-specific") (:end . 64) (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 88) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x27.13.1) (:span 11 17)))\n (:hscopes ((:id . :x27.13.1) (:span 11 122)))\n (:identifiers (:sid . :s27.13) (:did . :|91224990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000248@unknown@formal@none@1@S@Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s28.1) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000250@unknown@formal@none@1@S@Okadaic acid was found to be a potent inducer of AP1.@(((:tag . "JJ") (:stem . "okadaic") (:form . "Okadaic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s28.3) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000251@unknown@formal@none@1@S@In contrast to phorbol esters such as phorbol myristate acetate (PMA), the induction of AP1 by okadaic acid occurs predominantly by transcriptional activation of the jun and fos family of proto-oncogenes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 102)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 114)\n  (:start . 108) (:id . 63))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 128) (:start . 115) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 147) (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 203) (:start . 188) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s28.4) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000252@unknown@formal@none@1@S@Surprisingly, while the addition of phytohemagglutinin further enhanced the induction of AP1, the addition of PMA inhibited it.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 54) (:start . 36) (:id . 48))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s28.5) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000253@unknown@formal@none@1@S@Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto-oncogenes including c-jun, junD, and junB and to a lesser extent the fos family including c-fos and fra-1.@(((:tag . "JJ") (:stem . "okadaic") (:form . "Okadaic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 111) (:start . 96) (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "jund") (:form . "junD") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 181)\n  (:start . 175) (:id . 72))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 191)\n  (:start . 182) (:id . 73))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 197)\n  (:start . 192) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 207)\n  (:start . 202) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s28.6) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000254@unknown@formal@none@1@S@By comparison, PMA is a very inefficient inducer of the jun gene family in Jurkat cells.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inefficient") (:form . "inefficient") (:end . 40)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s28.7) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000255@unknown@formal@none@1@S@Similar to its effect on the induction of AP1 by okadaic acid, PMA inhibits the induction of c-jun mRNA by okadaic acid.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s28.8) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000256@unknown@formal@none@1@S@Transfection of c-jun promoter constructs confirmed the marked difference between PMA and okadaic acid in inducing c-jun transcription.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 134) (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s28.9) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000257@unknown@formal@none@1@S@The induction of AP1 by okadaic acid suggests that protein phosphatases 1 and 2A (PP1 and PP2A) may be involved in T cell activation as important negative regulators of the transcription factor AP1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PP1") (:form . "PP1") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PP2A") (:form . "PP2A") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 111)\n  (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 135) (:start . 133)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 145)\n  (:start . 136) (:id . 69))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 154)\n  (:start . 146) (:id . 70))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 165)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 186) (:start . 173) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 193)\n  (:start . 187) (:id . 75))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 197) (:start . 194)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x28.10.1) (:span 96 99)) ((:id . :x28.10.2) (:span 37 45)))\n (:hscopes ((:id . :x28.10.1) (:span 96 197))\n  ((:id . :x28.10.2) (:span 37 197)))\n (:identifiers (:sid . :s28.10) (:did . :|91236696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000258@unknown@formal@none@1@S@Demonstration of estrogen and progesterone receptors as well as Ki-67 and p-145 antigens in single tumor cells from blood and pleural effusions using a slide assay.@(((:tag . "NN") (:stem . "demonstration") (:form . "Demonstration")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p-145") (:form . "p-145") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pleural") (:form . "pleural") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "effusion") (:form . "effusions") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 149) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "slide") (:form . "slide") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s29.1) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000260@unknown@formal@none@1@S@With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly malignant lymphomas.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "anti-p-145") (:form . "anti-p-145") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nucleolar") (:form . "nucleolar") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s29.3) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000261@unknown@formal@none@1@S@An almost identical reaction was obtained when tumor cells from malignant effusions were tested.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "effusion") (:form . "effusions") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 95) (:start . 89)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s29.4) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000262@unknown@formal@none@1@S@Cells isolated from the blood of patients with leukemic spread of lymphomas of low malignancy yielded a weak staining comparable to that of normal mesothelial cells from non-tumorous cavity fluids.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "spread") (:form . "spread") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "malignancy") (:form . "malignancy") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "VBD") (:stem . "yield") (:form . "yielded") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "JJ") (:stem . "mesothelial") (:form . "mesothelial") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "non-tumorous") (:form . "non-tumorous") (:end . 182)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "cavity") (:form . "cavity") (:end . 189)\n  (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "fluid") (:form . "fluids") (:end . 196)\n  (:start . 190) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s29.5) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000263@unknown@formal@none@1@S@The detection of estrogen and progesterone receptors (ER and PR) localized in the cell nucleus can be achieved by the same assay.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s29.6) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000264@unknown@formal@none@1@S@The reaction is enhanced by incubation of the tumor cells for 30 min at 37 degrees C prior to fixation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "JJ") (:stem . "c") (:form . "C") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "fixation") (:form . "fixation") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s29.7) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000265@unknown@formal@none@1@S@Pleural effusions from 20 patients with breast cancer were tested.@(((:tag . "JJ") (:stem . "pleural") (:form . "Pleural") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effusion") (:form . "effusions") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 65) (:start . 59)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s29.8) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000266@unknown@formal@none@1@S@ER was positive in 13 and PR was positive in 12 of the 20 samples.@(((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 41)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 54))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 57) (:start . 55)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 65)\n  (:start . 58) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s29.9) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000267@unknown@formal@none@1@S@In 5 cases there was a divergent reaction with ER and PR antibody.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s29.10) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000268@unknown@formal@none@1@S@The hormone receptors of the primary tumor were known in 15 (ER) and 14 (PR) patients, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 71) (:start . 69)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 75) (:start . 73)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 85)\n  (:start . 77) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 62))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 99)\n  (:start . 87) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s29.11) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000270@unknown@formal@none@1@S@These results indicate that the demonstration of hormone receptor proteins in cells from malignant effusions is possible and that there is a correlation with the status of the primary site of cancer.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "effusion") (:form . "effusions") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 198)\n  (:start . 192) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x29.13.1) (:span 112 120))\n  ((:id . :x29.13.2) (:span 14 27)))\n (:hscopes ((:id . :x29.13.1) (:span 28 120))\n  ((:id . :x29.13.2) (:span 14 198)))\n (:identifiers (:sid . :s29.13) (:did . :|91236793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000271@unknown@formal@none@1@S@Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA.@(((:tag . "VBG") (:stem . "transform") (:form . "Transforming") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 19)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 42)\n  (:start . 32) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 99)\n  (:start . 90) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 114)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s30.1) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000272@unknown@formal@none@1@S@Transforming growth factor-beta (TGF-beta) inhibits B cell Ig secretion and reduces B cell membrane Ig expression.@(((:tag . "VBG") (:stem . "transform") (:form . "Transforming") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 19)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s30.2) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000273@unknown@formal@none@1@S@The addition of TGF-beta to human B lymphocyte cultures stimulated with Staphylococcus aureus Cowan strain I and IL-2 completely inhibited B cell Ig secretion (greater than 90 %) and decreased B cell surface IgM, IgD, kappa L chain, and lambda L chain expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . 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5000274@unknown@formal@none@1@S@In contrast, TGF-beta had only minimal effects on two other B cell membrane proteins, HLA-DR and CD20.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s30.4) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000275@unknown@formal@none@1@S@Internal labeling with [35S]methionine and immunoprecipitation with anti-IgM, anti-kappa, and anti-lambda antibodies revealed a striking reduction in kappa L chain in the presence of TGF-beta.@(((:tag . "JJ") (:stem . "internal") (:form . "Internal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "labeling") (:form . "labeling") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "35S]methionine") (:form . "35S]methionine")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 62) (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-igm") (:form . "anti-IgM") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-kappa") (:form . "anti-kappa") (:end . 88)\n  (:start . 78) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anti-lambda") (:form . "anti-lambda") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 146)\n  (:start . 137) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 157) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 163)\n  (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 179)\n  (:start . 171) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s30.5) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000276@unknown@formal@none@1@S@A less pronounced reduction in lambda L chain and microH chain was also noted.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "lambda") (:form . "lambda") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "microh") (:form . "microH") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s30.6) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000277@unknown@formal@none@1@S@Northern blot analysis of RNA purified from B cells treated with TGF-beta for varying time intervals revealed a significant decrease in steady state kappa and lambda L chain mRNA levels.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "vary") (:form . "varying") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "interval") (:form . "intervals") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "lambda") (:form . "lambda") (:end . 165)\n  (:start . 159) (:id . 67))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s30.7) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000278@unknown@formal@none@1@S@Furthermore, a significant decrease in the switch from the membrane forms of mu and gamma to their respective secreted forms was noted in the presence of TGF-beta.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 98)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . "JJ") (:stem . "secreted") (:form . "secreted") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s30.8) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000280@unknown@formal@none@1@S@The effects of TGF-beta on two transcriptional regulatory factors, Oct-2 and nuclear factor (NF) kappa B, known to be important in Ig gene transcription were examined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 46) (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 127)\n  (:start . 118) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 133) (:start . 131)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 166)\n  (:start . 158) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s30.10) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000281@unknown@formal@none@1@S@Oct-2 mRNA levels and both Oct-2 and NF-kappa B proteins in nuclear extracts were not altered by treatment with TGF-beta.@(((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x30.11.1) (:span 82 85)))\n (:nscopes ((:id . :x30.11.1) (:span 0 120)))\n (:identifiers (:sid . :s30.11) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000282@unknown@formal@none@1@S@In contrast, levels of the transcriptional factor AP-1, which is not known to be important in B cell Ig production, were reduced by TGF-beta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 42) (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 114)\n  (:start . 104) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 128)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 140)\n  (:start . 132) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x30.12.1) (:span 65 68)))\n (:nscopes ((:id . :x30.12.1) (:span 56 114)))\n (:identifiers (:sid . :s30.12) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000283@unknown@formal@none@1@S@These findings demonstrate that TGF-beta decreases B lymphocyte Ig secretion by inhibiting the synthesis of Ig mRNA and inhibiting the switch from the membrane form to the secreted forms of mu and gamma mRNA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 141)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 180)\n  (:start . 172) (:id . 69))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 202)\n  (:start . 197) (:id . 74))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 207) (:start . 203)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s30.13) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000284@unknown@formal@none@1@S@The mechanism by which TGF-beta inhibits Ig chain synthesis is unclear although it does not involve inhibition of the binding of NF-kappa B or Oct-2 to their respective target sequences.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 175)\n  (:start . 169) (:id . 70))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 185)\n  (:start . 176) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x30.14.2) (:span 63 70)))\n (:ncues ((:id . :x30.14.1) (:span 88 91)))\n (:hscopes ((:id . :x30.14.2) (:span 0 70)))\n (:nscopes ((:id . :x30.14.1) (:span 88 185)))\n (:identifiers (:sid . :s30.14) (:did . :|91237114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000285@unknown@formal@none@1@S@Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.@(((:tag . "JJ") (:stem . "differentiation-associated")\n  (:form . "Differentiation-associated") (:end . 26) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 57)\n  (:start . 45) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 63) (:start . 58)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 69) (:start . 64)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 84) (:start . 70) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 100) (:start . 96)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hairy") (:form . "hairy") (:end . 106)\n  (:start . 101) (:id . 53))\n ((:tag . "NN") (:stem . "leukoplakia") (:form . "leukoplakia") (:end . 118)\n  (:start . 107) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s31.1) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000286@unknown@formal@none@1@S@The BZLF1 protein of Epstein-Barr virus (EBV) is a key immediate-early protein which has been shown to disrupt virus latency in EBV-infected B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 70) (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ebv-infected") (:form . "EBV-infected") (:end . 140)\n  (:start . 128) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s31.2) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000287@unknown@formal@none@1@S@We have generated a monoclonal antibody, BZ1, to BZLF1 which reacts in immunohistology, immunoblotting, and immunoprecipitation and which recognizes both the active, dimeric form and the inactive, monomeric form of the protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "BZ1") (:form . "BZ1") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "react") (:form . "reacts") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunohistology") (:form . "immunohistology")\n  (:end . 86) (:start . 71) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunoblotting") (:form . "immunoblotting")\n  (:end . 102) (:start . 88) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 127) (:start . 108) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "dimeric") (:form . "dimeric") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "monomeric") (:form . "monomeric") (:end . 206)\n  (:start . 197) (:id . 75))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 211) (:start . 207)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 226)\n  (:start . 219) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s31.3) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000288@unknown@formal@none@1@S@Biopsies of oral hairy leukoplakia, an AIDS-associated lesion characterized by high-level EBV replication, were examined by immunohistochemistry using the BZ1 monoclonal antibody.@(((:tag . "NNS") (:stem . "biopsy") (:form . "Biopsies") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hairy") (:form . "hairy") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "leukoplakia") (:form . "leukoplakia") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "aids-associated") (:form . "AIDS-associated")\n  (:end . 54) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "lesion") (:form . "lesion") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 75) (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 144) (:start . 124) (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 150) (:start . 145)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bz1") (:form . "BZ1") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 178)\n  (:start . 170) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s31.4) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000290@unknown@formal@none@1@S@This finding suggests that the BZLF1 promoter may be regulated by the degree of squamous differentiation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "squamous") (:form . "squamous") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 104) (:start . 89) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x31.6.1) (:span 46 49)) ((:id . :x31.6.2) (:span 13 21)))\n (:hscopes ((:id . :x31.6.1) (:span 27 104))\n  ((:id . :x31.6.2) (:span 13 104)))\n (:identifiers (:sid . :s31.6) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000291@unknown@formal@none@1@S@A comparison of in situ hybridization to EBV DNA and viral capsid antigen staining with BZ1 reactivity suggested that BZLF1 expression precedes rampant virus replication.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "capsid") (:form . "capsid") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "VBG") (:stem . "stain") (:form . "staining") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bz1") (:form . "BZ1") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "VBZ") (:stem . "precede") (:form . "precedes") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "JJ") (:stem . "rampant") (:form . "rampant") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 169)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x31.7.1) (:span 103 112)))\n (:hscopes ((:id . :x31.7.1) (:span 103 169)))\n (:identifiers (:sid . :s31.7) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000292@unknown@formal@none@1@S@The inability to detect EBV in the lower epithelial layers of oral hairy leukoplakia raises questions concerning the nature of EBV latency and persistence in stratified squamous epithelium.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "layer") (:form . "layers") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hairy") (:form . "hairy") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "leukoplakia") (:form . "leukoplakia") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "question") (:form . "questions") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "VBG") (:stem . "concern") (:form . "concerning") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "stratified") (:form . "stratified") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . "JJ") (:stem . "squamous") (:form . "squamous") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "epithelium") (:form . "epithelium") (:end . 188)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x31.8.1) (:span 85 101)))\n (:hscopes ((:id . :x31.8.1) (:span 85 188)))\n (:identifiers (:sid . :s31.8) (:did . :|91237800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000293@unknown@formal@none@1@S@Transactivation of the human immunodeficiency virus promoter by human herpesvirus 6 (HHV-6) strains GS and Z-29 in primary human T lymphocytes and identification of transactivating HHV-6 ( GS ) gene fragments.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 45) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 81)\n  (:start . 70) (:id . 51))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hhv-6") (:form . "HHV-6") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "gs") (:form . "GS") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "z-29") (:form . "Z-29") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 142)\n  (:start . 131) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 161) (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 180) (:start . 165) (:id . 68))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 186)\n  (:start . 181) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GS") (:form . "GS") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 198) (:start . 194)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 208)\n  (:start . 199) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s32.1) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000294@unknown@formal@none@1@S@Human herpesvirus 6 (HHV-6) can activate the human immunodeficiency virus (HIV) promoter and accelerate cytopathic effects in HIV-infected human T cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hhv-6") (:form . "HHV-6") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 67) (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "VB") (:stem . "accelerate") (:form . "accelerate") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "cytopathic") (:form . "cytopathic") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 138)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s32.2) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000295@unknown@formal@none@1@S@This study examines the regions of the HIV promoter required for HHV-6 transactivation in a heterogeneous population of primary human T lymphocytes with or without antigenic stimulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "examine") (:form . "examines") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 86) (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 185)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x32.3.1) (:span 156 163)))\n (:nscopes ((:id . :x32.3.1) (:span 156 185)))\n (:identifiers (:sid . :s32.3) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000296@unknown@formal@none@1@S@Two different strains of HHV-6, GS and Z29, transactivated the HIV promoter.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GS") (:form . "GS") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Z29") (:form . "Z29") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 58) (:start . 44) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s32.4) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000297@unknown@formal@none@1@S@The GS strain transactivated the promoter in both stimulated and resting T cells, while the Z29 strain increased HIV promoter activity only in stimulated T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gs") (:form . "GS") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "z29") (:form . "Z29") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s32.5) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000298@unknown@formal@none@1@S@Three DNA clones containing HHV-6 ( GS ) genomic fragments transactivated the HIV promoter in cotransfected T cells.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GS") (:form . "GS") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 73) (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s32.6) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000300@unknown@formal@none@1@S@One of these clones, pZVH14, activated the HIV promoter construct containing a mutation in the NF kappa B site.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pzvh14") (:form . "pZVH14") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s32.8) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000301@unknown@formal@none@1@S@However, this mutated NF kappa B promoter was not transactivated during HHV-6 ( GS ) infection or after cotransfection with pZVB70 or pZVB10.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 64) (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GS") (:form . "GS") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 118) (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pzvb70") (:form . "pZVB70") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pzvb10") (:form . "pZVB10") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x32.9.1) (:span 46 49)))\n (:nscopes ((:id . :x32.9.1) (:span 9 140)))\n (:identifiers (:sid . :s32.9) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000302@unknown@formal@none@1@S@These data indicate that the NF kappa B sites of the HIV promoter are essential for its transactivation during HHV-6 ( GS ) infection.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 103) (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GS") (:form . "GS") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 133)\n  (:start . 124) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x32.10.1) (:span 11 24)))\n (:hscopes ((:id . :x32.10.1) (:span 11 133)))\n (:identifiers (:sid . :s32.10) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000303@unknown@formal@none@1@S@By increasing HIV promoter activity in primary T lymphocytes, HHV-6 may consequently increase HIV replication, leading to an increase in the cytopathic effect on coinfected human T cells.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "consequently") (:form . "consequently") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cytopathic") (:form . "cytopathic") (:end . 151)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 158)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "coinfecte") (:form . "coinfected") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x32.11.1) (:span 68 71)))\n (:hscopes ((:id . :x32.11.1) (:span 68 186)))\n (:identifiers (:sid . :s32.11) (:did . :|91237803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000304@unknown@formal@none@1@S@The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "LIM-domain") (:form . "LIM-domain") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "oncogene") (:form . "oncogenes") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 114) (:start . 100) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 135)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "11p15") (:form . "11p15") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "11p13") (:form . "11p13") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s33.1) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000305@unknown@formal@none@1@S@A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at band 11p15 disrupts the rhombotin gene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "arm") (:form . "arm") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "11p15") (:form . "11p15") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "VBZ") (:stem . "disrupt") (:form . "disrupts") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s33.2) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000306@unknown@formal@none@1@S@This gene encodes a protein with duplicated cysteine-rich regions called LIM domains, which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "duplicated") (:form . "duplicated") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 72) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LIM") (:form . "LIM") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "zinc-binding") (:form . "zinc-binding") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "iron-sulfur") (:form . "iron-sulfur") (:end . 149)\n  (:start . 138) (:id . 63))\n ((:tag . "NNS") (:stem . "center") (:form . "centers") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "ferredoxin") (:form . "ferredoxins") (:end . 172)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s33.3) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000307@unknown@formal@none@1@S@Two homologues of the rhombotin gene have now been isolated.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "homologue") (:form . "homologues") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s33.4) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000308@unknown@formal@none@1@S@One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur;@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 24)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "rhom-2") (:form . "Rhom-2") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "11p13") (:form . "11p13") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 97)\n  (:start . 90) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 107)\n  (:start . 101) (:id . 63))\n ((:tag . "JJ") (:stem . "leukemia-specific") (:form . "leukemia-specific")\n  (:end . 125) (:start . 108) (:id . 64))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 140) (:start . 126) (:id . 65))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s33.5) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000310@unknown@formal@none@1@S@Human and mouse Rhom-2 are highly conserved and , like rhombotin, encode two tandem cysteine-rich LIM domains.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rhom-2") (:form . "Rhom-2") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 97) (:start . 84) (:id . 57))\n ((:tag . "NNP") (:stem . "LIM") (:form . "LIM") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s33.7) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000311@unknown@formal@none@1@S@Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus.@(((:tag . "NNP") (:stem . "Rhom-2") (:form . "Rhom-2") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kidney") (:form . "kidney") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 135)\n  (:start . 129) (:id . 67))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 141)\n  (:start . 136) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 69))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 151)\n  (:start . 145) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s33.8) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000312@unknown@formal@none@1@S@The other gene, designated Rhom-3, is not on chromosome 11 but also retains homology to the LIM domain of rhombotin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NNP") (:stem . "Rhom-3") (:form . "Rhom-3") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 55)\n  (:start . 45) (:id . 52))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "retain") (:form . "retains") (:end . 75)\n  (:start . 68) (:id . 56))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LIM") (:form . "LIM") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 102)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 115)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x33.9.1) (:span 38 41)))\n (:nscopes ((:id . :x33.9.1) (:span 38 58)))\n (:identifiers (:sid . :s33.9) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000313@unknown@formal@none@1@S@Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors, the consistency of translocations near the rhombotin gene was further examined.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "rhom-2") (:form . "Rhom-2") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 58)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "consistency") (:form . "consistency") (:end . 99)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 117) (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 153)\n  (:start . 146) (:id . 67))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 162)\n  (:start . 154) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s33.10) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000314@unknown@formal@none@1@S@A second translocation adjacent to rhombotin was found and at the same position as in the previous example.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s33.11) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000315@unknown@formal@none@1@S@Therefore, chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "band") (:form . "bands") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "11p15") (:form . "11p15") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "11p13") (:form . "11p13") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rhom-2") (:form . "Rhom-2") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 99)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 113) (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "CD") (:stem . "11p15") (:form . "11p15") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "RB") (:stem . "rarely") (:form . "rarely") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 176)\n  (:start . 168) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s33.12) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000316@unknown@formal@none@1@S@The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rhombotin") (:form . "rhombotin") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "oncogene") (:form . "oncogenes") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "duplicate") (:form . "duplicated") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NNP") (:stem . "LIM") (:form . "LIM") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s33.13) (:did . :|91239569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000317@unknown@formal@none@1@S@The human myelomonocytic cell line U-937 as a model for studying alterations in steroid-induced monokine gene expression: marked enhancement of lipopolysaccharide-stimulated interleukin-1 beta messenger RNA levels by 1,25-dihydroxyvitamin D3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 24) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "steroid-induced") (:form . "steroid-induced")\n  (:end . 95) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "monokine") (:form . "monokine") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 128)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 173) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 187) (:start . 174) (:id . 64))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 192) (:start . 188)\n  (:id . 65))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 202)\n  (:start . 193) (:id . 66))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 206) (:start . 203)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 213)\n  (:start . 207) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 216) (:start . 214)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 238) (:start . 217) (:id . 70))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 241) (:start . 239)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s34.1) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000318@unknown@formal@none@1@S@The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], is a potent regulator of human monocyte/macrophage function in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 57) (:start . 36) (:id . 49))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 127) (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s34.2) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000320@unknown@formal@none@1@S@All three cell lines expressed vitamin D receptor and had increased levels of IL-1 beta mRNA in response to LPS.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s34.4) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000321@unknown@formal@none@1@S@Preincubation of cells with 1,25-(OH)2D3 augmented IL-1 beta mRNA levels only in U-937 and HL-60 cells.@(((:tag . "NN") (:stem . "preincubation") (:form . "Preincubation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s34.5) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000322@unknown@formal@none@1@S@From these data, and taking into consideration their state of differentiation and relative ease of culture, U-937 was chosen over HL-60 and THP-1 as the cell line we further characterized.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 27) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consideration") (:form . "consideration")\n  (:end . 46) (:start . 33) (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 52)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 77) (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "ease") (:form . "ease") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "U-937") (:form . "U-937") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 162) (:start . 158)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 173)\n  (:start . 166) (:id . 72))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 187) (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s34.6) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000323@unknown@formal@none@1@S@In U-937 cells, optimum time and dose of pretreatment with 1,25-(OH)2D3 were determined to be 12-24 h at a receptor saturating concentration of 1,25-(OH)2D3 (10 nM).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "optimum") (:form . "optimum") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 53)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "12-24") (:form . "12-24") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "VBG") (:stem . "saturate") (:form . "saturating") (:end . 126)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 140) (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3")\n  (:end . 156) (:start . 144) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s34.7) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000324@unknown@formal@none@1@S@Preincubation of cells with 1,25-(OH)2D3 had no effect on the time course of IL-1 beta mRNA appearance in response to LPS.@(((:tag . "NN") (:stem . "preincubation") (:form . "Preincubation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x34.8.1) (:span 45 47)))\n (:nscopes ((:id . :x34.8.1) (:span 45 121)))\n (:identifiers (:sid . :s34.8) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000325@unknown@formal@none@1@S@However, exposure of U-937 cells to 1,25-(OH)2D3 increased by 200 % the level of IL-1 beta mRNA detected and decreased by three orders of magnitude the concentration of LPS required to achieve steady state mRNA levels equivalent to those observed in U-937 cells not preincubated with the hormone.2+o@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . 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"the") (:end . 287) (:start . 284)\n  (:id . 89))\n ((:tag . "NN") (:stem . "hormone.2+o") (:form . "hormone.2+o") (:end . 299)\n  (:start . 288) (:id . 90)))@@@1@49@((:ncues ((:id . :x34.9.1) (:span 262 265)))\n (:nscopes ((:id . :x34.9.1) (:span 262 299)))\n (:identifiers (:sid . :s34.9) (:did . :|91246215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000326@unknown@formal@none@1@S@Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic ( CEM ) cells.@(((:tag . "NNP") (:stem . "Cortivazol") (:form . "Cortivazol") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 47) (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 66)\n  (:start . 57) (:id . 48))\n ((:tag . "JJ") (:stem . "ribonucleic") (:form . "ribonucleic") (:end . 78)\n  (:start . 67) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 83) (:start . 79)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dexamethasone-resistant")\n  (:form . "dexamethasone-resistant") (:end . 124) (:start . 101) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 130)\n  (:start . 125) (:id . 55))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 139)\n  (:start . 131) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 145) (:start . 142)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s35.1) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000327@unknown@formal@none@1@S@Cortivazol is a phenylpyrazolo glucocorticoid of high potency and unusual structure.@(((:tag . "NNP") (:stem . "Cortivazol") (:form . "Cortivazol") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "phenylpyrazolo") (:form . "phenylpyrazolo")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 45) (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s35.2) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000328@unknown@formal@none@1@S@In both wild-type and highly dexamethasone(dex)-resistant clones of the human leukemic cell line CEM, exposure to cortivazol leads to cell death.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "dexamethasone(dex)-resistant")\n  (:form . "dexamethasone(dex)-resistant") (:end . 57) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 64)\n  (:start . 58) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cortivazol") (:form . "cortivazol") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s35.3) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000330@unknown@formal@none@1@S@To test the hypothesis that cortivazol acts in dex-resistant cells by making use of the residual GR found there, wild-type and dex-resistant clones were treated with various concentrations of cortivazol and induction of GR mRNA was studied.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cortivazol") (:form . "cortivazol") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 76) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "residual") (:form . "residual") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "RB") (:stem . "there") (:form . "there") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 140) (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 160)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 188) (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cortivazol") (:form . "cortivazol") (:end . 202)\n  (:start . 192) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 216)\n  (:start . 207) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 222) (:start . 220)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 227) (:start . 223)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 231) (:start . 228)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 239)\n  (:start . 232) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x35.5.1) (:span 12 22)))\n (:hscopes ((:id . :x35.5.1) (:span 12 111)))\n (:identifiers (:sid . :s35.5) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000331@unknown@formal@none@1@S@Cortivazol significantly induced GR mRNA in the normal CEM-C7 as well as in two classes of dex-resistant clones, although the dex-resistant clones needed at least 10 times more cortivazol than the normal cells for significant GR mRNA induction.@(((:tag . "NNP") (:stem . "Cortivazol") (:form . "Cortivazol") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 24) (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "cem-c7") (:form . "CEM-C7") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 139) (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cortivazol") (:form . "cortivazol") (:end . 187)\n  (:start . 177) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 192) (:start . 188)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 203)\n  (:start . 197) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 209)\n  (:start . 204) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 213) (:start . 210)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 225)\n  (:start . 214) (:id . 77))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 233) (:start . 229)\n  (:id . 79))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 243)\n  (:start . 234) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s35.6) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000332@unknown@formal@none@1@S@Increased levels of GR mRNA were noticed as early as 3 h after treatment.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "notice") (:form . "noticed") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 72)\n  (:start . 63) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s35.7) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000333@unknown@formal@none@1@S@A general correlation between induction of GR mRNA and lysis of the normal and dex-resistant cells was found.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s35.8) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000334@unknown@formal@none@1@S@Positive induction of GR mRNA might be one of the earliest crucial steps in the lysis of normal and dex-resistant CEM cells, or might serve as a marker for the process.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 113) (:start . 100) (:id . 61))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 133)\n  (:start . 128) (:id . 66))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 69))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 151)\n  (:start . 145) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 155) (:start . 152)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 167)\n  (:start . 160) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x35.9.1) (:span 128 133)) ((:id . :x35.9.3) (:span 125 127))\n  ((:id . :x35.9.2) (:span 30 35)))\n (:hscopes ((:id . :x35.9.1) (:span 128 167))\n  ((:id . :x35.9.3) (:span 30 123)) ((:id . :x35.9.2) (:span 30 167)))\n (:identifiers (:sid . :s35.9) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000335@unknown@formal@none@1@S@However, the lysis pathway in the dex-resistant cells is defective in that dex-resistant clones needed significantly more cortivazol than the normal cells for lysis of the cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dex-resistant") (:form . "dex-resistant")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "VBD") (:stem . "need") (:form . "needed") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cortivazol") (:form . "cortivazol") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s35.10) (:did . :|91248763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000336@unknown@formal@none@1@S@Expression of 1,25(OH)2D3 receptors on alveolar lymphocytes from patients with pulmonary granulomatous diseases.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "JJ") (:stem . "granulomatous") (:form . "granulomatous")\n  (:end . 102) (:start . 89) (:id . 53))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 111)\n  (:start . 103) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s36.1) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000337@unknown@formal@none@1@S@1,25(OH)2D3 is known to be produced at sites of granulomatous reactions.@(((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "granulomatous") (:form . "granulomatous")\n  (:end . 61) (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s36.2) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000338@unknown@formal@none@1@S@In order to characterize the cell types that are targets for this immunoregulatory hormone, we have evaluated the expression of 1,25(OH)2D3 receptors on peripheral blood T-lymphocytes and those recovered from the lung by bronchoalveolar lavage from patients with pulmonary granulomatous diseases (tuberculosis and sarcoidosis) and from normal control subjects using combined autoradiographic and immunohistochemical techniques.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . 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5000340@unknown@formal@none@1@S@In contrast, blood lymphocytes from patients with granulomatous diseases did not express detectable 1,25(OH)2D3 receptors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "granulomatous") (:form . "granulomatous")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 111)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x36.5.1) (:span 77 80)))\n (:nscopes ((:id . :x36.5.1) (:span 77 121)))\n (:identifiers (:sid . :s36.5) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000341@unknown@formal@none@1@S@The percentage of lavage T-lymphocytes expressing 1,25(OH)2D3 receptors was significantly greater for patients with tuberculosis presenting with isolated hilar adenopathy than for patients with pulmonary infiltrates and/or cavities.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lavage") (:form . "lavage") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 71)\n  (:start . 62) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 97)\n  (:start . 90) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 110)\n  (:start . 102) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 128)\n  (:start . 116) (:id . 56))\n ((:tag . "VBG") (:stem . "present") (:form . "presenting") (:end . 139)\n  (:start . 129) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 153)\n  (:start . 145) (:id . 59))\n ((:tag . "JJ") (:stem . "hilar") (:form . "hilar") (:end . 159)\n  (:start . 154) (:id . 60))\n ((:tag . "NN") (:stem . "adenopathy") (:form . "adenopathy") (:end . 170)\n  (:start . 160) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 175) (:start . 171)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 188)\n  (:start . 180) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 203)\n  (:start . 194) (:id . 66))\n ((:tag . "NNS") (:stem . "infiltrate") (:form . "infiltrates") (:end . 215)\n  (:start . 204) (:id . 67))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 222)\n  (:start . 216) (:id . 68))\n ((:tag . "NNS") (:stem . "cavity") (:form . "cavities") (:end . 231)\n  (:start . 223) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s36.6) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000342@unknown@formal@none@1@S@1,25(OH)2D3 receptors were expressed to a greater extent on CD8+ T-lymphocytes than on CD4+ T-lymphocytes in sarcoidosis, whereas a greater proportion of CD4+ than of CD8+ T-lymphocytes from patients with tuberculosis were receptor-positive.@(((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 78) (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 105) (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sarcoidosis") (:form . "sarcoidosis") (:end . 120)\n  (:start . 109) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 185) (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 199)\n  (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 204) (:start . 200)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 217)\n  (:start . 205) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 222) (:start . 218)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "receptor-positive") (:form . "receptor-positive")\n  (:end . 240) (:start . 223) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s36.7) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000343@unknown@formal@none@1@S@These findings support the conclusion that the interaction of 1,25(OH)2D3 with its receptor on T-lymphocytes may play an important role in the regulation of granulomatous reactions, but because these receptors are expressed on different lymphocyte populations, the net effect of this potent immunoregulatory molecule is likely different in sarcoidosis and tuberculosis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . 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(:end . 369) (:start . 368)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x36.8.1) (:span 320 326))\n  ((:id . :x36.8.2) (:span 109 112)))\n (:hscopes ((:id . :x36.8.1) (:span 320 368))\n  ((:id . :x36.8.2) (:span 109 180)))\n (:identifiers (:sid . :s36.8) (:did . :|91264362|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000344@unknown@formal@none@1@S@Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rel/nf-kappa") (:form . "rel/NF-kappa") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transdominant") (:form . "transdominant")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s37.1) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000345@unknown@formal@none@1@S@The KBF1 factor, which binds to the enhancer A located in the promoter of the mouse MHC class I gene H-2Kb, is indistinguishable from the p50 DNA binding subunit of the transcription factor NF-kappa B, which regulates a series of genes involved in immune and inflammatory responses.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . 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"which") (:end . 207)\n  (:start . 202) (:id . 80))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 217)\n  (:start . 208) (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 219) (:start . 218)\n  (:id . 82))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 226)\n  (:start . 220) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 235)\n  (:start . 230) (:id . 85))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 244)\n  (:start . 236) (:id . 86))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 254)\n  (:start . 248) (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 258) (:start . 255)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . 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5000346@unknown@formal@none@1@S@The KBF1/p50 factor binds as a homodimer but can also form heterodimers with the products of other members of the same family, like the c-rel and v-rel ( proto ) oncogenes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kbf1/p50") (:form . "KBF1/p50") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 141)\n  (:start . 136) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "v-rel") (:form . "v-rel") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "NN") (:stem . "proto") (:form . "proto") (:end . 159)\n  (:start . 154) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "oncogene") (:form . "oncogenes") (:end . 171)\n  (:start . 162) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s37.3) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000347@unknown@formal@none@1@S@The dimerization domain of KBF1/p50 is contained between amino acids 201 and 367.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "KBF1/p50") (:form . "KBF1/p50") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "CD") (:stem . "201") (:form . "201") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "367") (:form . "367") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s37.4) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000348@unknown@formal@none@1@S@A mutant of KBF1/p50 ( delta SP ), unable to bind to DNA but able to form homo- or heterodimers, has been constructed.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "KBF1/p50") (:form . "KBF1/p50") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "delta") (:form . "delta") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 41)\n  (:start . 35) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 49) (:start . 45)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 56) (:start . 53)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 60) (:start . 57)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 65) (:start . 61)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 58))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 73) (:start . 69)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "homo-") (:form . "homo-") (:end . 79) (:start . 74)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 95)\n  (:start . 83) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 100) (:start . 97)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 105) (:start . 101)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 117)\n  (:start . 106) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x37.5.1) (:span 35 41)))\n (:nscopes ((:id . :x37.5.1) (:span 35 56)))\n (:identifiers (:sid . :s37.5) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000350@unknown@formal@none@1@S@This mutant also functions in vivo as a trans-acting dominant negative regulator:@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "trans-acting") (:form . "trans-acting") (:end . 52)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s37.7) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000351@unknown@formal@none@1@S@the transcriptional inducibility of the HIV long terminal repeat (which contains two potential NF-kappa B binding sites) by phorbol ester (PMA) is inhibited when it is co-transfected into CD4+ T cells with the delta SP mutant.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "co-transfecte") (:form . "co-transfected")\n  (:end . 182) (:start . 168) (:id . 72))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 194) (:start . 193)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 200)\n  (:start . 195) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 205) (:start . 201)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 215)\n  (:start . 210) (:id . 79))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 218) (:start . 216)\n  (:id . 80))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 225)\n  (:start . 219) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s37.8) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000352@unknown@formal@none@1@S@Similarly the basal as well as TNF or IL1-induced activity of the MHC class I H-2Kb promoter can be inhibited by this mutant in two different cell lines.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "il1-induced") (:form . "IL1-induced") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "H-2Kb") (:form . "H-2Kb") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 124)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s37.9) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000353@unknown@formal@none@1@S@These results constitute the first formal demonstration that these genes are regulated by members of the rel/NF-kappa B family.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "formal") (:form . "formal") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 55) (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rel/nf-kappa") (:form . "rel/NF-kappa") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s37.10) (:did . :|91266912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000354@unknown@formal@none@1@S@Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "5-aminolevulinate") (:form . "5-aminolevulinate")\n  (:end . 33) (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 42)\n  (:start . 34) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 43) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 80) (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "iron-responsive") (:form . "iron-responsive")\n  (:end . 102) (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 110)\n  (:start . 103) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s38.1) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000355@unknown@formal@none@1@S@5-Aminolevulinate synthase (ALAS) catalyzes the first step of the heme biosynthetic pathway.@(((:tag . "NNP") (:stem . "5-Aminolevulinate") (:form . "5-Aminolevulinate")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "synthase") (:form . "synthase") (:end . 26)\n  (:start . 18) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "catalyze") (:form . "catalyzes") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "heme") (:form . "heme") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "biosynthetic") (:form . "biosynthetic") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s38.2) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000356@unknown@formal@none@1@S@cDNA clones for the human erythroid ALAS isozyme were isolated from a fetal liver library.@(((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "isozyme") (:form . "isozyme") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s38.3) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000357@unknown@formal@none@1@S@It can be deduced that the erythroid ALAS precursor protein has a molecular weight of 64.6 kd, and is similar in size to the previously isolated human housekeeping ALAS precursor of molecular weight 70.6 kd.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "deduce") (:form . "deduced") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "64.6") (:form . "64.6") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 66))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 135)\n  (:start . 125) (:id . 67))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 144)\n  (:start . 136) (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 150)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "housekeeping") (:form . "housekeeping") (:end . 163)\n  (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "alas") (:form . "ALAS") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 198)\n  (:start . 192) (:id . 75))\n ((:tag . "CD") (:stem . "70.6") (:form . "70.6") (:end . 203) (:start . 199)\n  (:id . 76))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 206) (:start . 204)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x38.4.1) (:span 3 17)))\n (:hscopes ((:id . :x38.4.1) (:span 0 206)))\n (:identifiers (:sid . :s38.4) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000358@unknown@formal@none@1@S@The mature mitochondrial forms of the erythroid and housekeeping ALAS isozymes are predicted to have molecular weights of 59.5 kd and 64.6 kd, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mitochondrial") (:form . "mitochondrial")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "housekeeping") (:form . "housekeeping") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "alas") (:form . "ALAS") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "isozyme") (:form . "isozymes") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NNS") (:stem . "weight") (:form . "weights") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "CD") (:stem . "59.5") (:form . "59.5") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "CD") (:stem . "64.6") (:form . "64.6") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 155)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x38.5.1) (:span 83 92)))\n (:hscopes ((:id . :x38.5.1) (:span 0 155)))\n (:identifiers (:sid . :s38.5) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000360@unknown@formal@none@1@S@An analysis of the immediate promoter of the human erythroid ALAS gene revealed several putative erythroid-specific cis-acting elements including both a GATA-1 and an NF-E2 binding site.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 115) (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 135)\n  (:start . 127) (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 145)\n  (:start . 136) (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 150) (:start . 146)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 159)\n  (:start . 153) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 180)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x38.7.1) (:span 88 96)))\n (:hscopes ((:id . :x38.7.1) (:span 88 135)))\n (:identifiers (:sid . :s38.7) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000361@unknown@formal@none@1@S@An iron-responsive element (IRE) motif has been identified in the 5'-untranslated region of the human erythroid ALAS mRNA, but is not present in the housekeeping ALAS mRNA.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "iron-responsive") (:form . "iron-responsive")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IRE") (:form . "IRE") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 81) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "housekeeping") (:form . "housekeeping") (:end . 161)\n  (:start . 149) (:id . 69))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x38.8.1) (:span 130 133)))\n (:nscopes ((:id . :x38.8.1) (:span 130 171)))\n (:identifiers (:sid . :s38.8) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000362@unknown@formal@none@1@S@Gel retardation experiments established that this IRE motif formed a protein-RNA complex with cytosolic extracts from human K562 cells and this binding was strongly competed with IRE transcripts from ferritin or transferrin receptor mRNAs.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IRE") (:form . "IRE") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 66) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "protein-rna") (:form . "protein-RNA") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "VBN") (:stem . "compete") (:form . "competed") (:end . 173)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ire") (:form . "IRE") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 194)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ferritin") (:form . "ferritin") (:end . 208)\n  (:start . 200) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 211) (:start . 209)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transferrin") (:form . "transferrin") (:end . 223)\n  (:start . 212) (:id . 73))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 232)\n  (:start . 224) (:id . 74))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 238)\n  (:start . 233) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s38.9) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000363@unknown@formal@none@1@S@A transcript of the ALAS IRE, mutated in the conserved loop of the IRE, did not readily form this protein-RNA complex.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IRE") (:form . "IRE") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 54)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IRE") (:form . "IRE") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 75) (:start . 72)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 59))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 87)\n  (:start . 80) (:id . 60))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 92) (:start . 88)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "protein-rna") (:form . "protein-RNA") (:end . 109)\n  (:start . 98) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 117)\n  (:start . 110) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x38.10.1) (:span 76 79)))\n (:nscopes ((:id . :x38.10.1) (:span 76 117)))\n (:identifiers (:sid . :s38.10) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000364@unknown@formal@none@1@S@These results suggest that the IRE motif in the ALAS mRNA is functional and imply that translation of the mRNA is controlled by cellular iron availability during erythropoiesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IRE") (:form . "IRE") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ALAS") (:form . "ALAS") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 154)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 176) (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x38.11.1) (:span 76 81)) ((:id . :x38.11.2) (:span 14 21)))\n (:hscopes ((:id . :x38.11.1) (:span 76 176))\n  ((:id . :x38.11.2) (:span 14 71)))\n (:identifiers (:sid . :s38.11) (:did . :|91266919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000365@unknown@formal@none@1@S@Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s39.1) (:did . :|91277630|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000366@unknown@formal@none@1@S@The minimal region of the human tumor necrosis factor alpha ( TNF-alpha ) gene promoter necessary for its transcriptional induction by phorbol esters (PMA) in human T and B lymphocyte cell lines has been localized between -52 and +89 nucleotides (nt) relative to the gene 's transcriptional start site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . 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5000367@unknown@formal@none@1@S@Comparison of these sequences to those required to mediate virus or lipopolysaccharide (LPS) induction of the gene reveal significant differences, and thus , the sequence requirements for PMA induction are distinct from those that mediate induction by virus or LPS.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 86) (:start . 68) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 133)\n  (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 183)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 201)\n  (:start . 192) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 214)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 219) (:start . 215)\n  (:id . 76))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 230) (:start . 226)\n  (:id . 78))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 238)\n  (:start . 231) (:id . 79))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 248)\n  (:start . 239) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 251) (:start . 249)\n  (:id . 81))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 257)\n  (:start . 252) (:id . 82))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 260) (:start . 258)\n  (:id . 83))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 264) (:start . 261)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s39.3) (:did . :|91277630|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000368@unknown@formal@none@1@S@Although three sites in the TNF-alpha promoter (kappa 1, kappa 2, and kappa 3) specifically bind the transcription factor NF-kappa B in lymphoid nuclear extracts, TNF-alpha mRNA induction by PMA does not correlate with NF-kappa B binding activities displayed by different T and B cell lines.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . 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5000370@unknown@formal@none@1@S@Therefore, TNF-alpha mRNA induction by PMA, like its induction by virus and LPS, is not primarily mediated by NF-kappa B, but rather is mediated through other sequences and protein factors.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 97)\n  (:start . 88) (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 106)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 132)\n  (:start . 126) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 135) (:start . 133)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 144)\n  (:start . 136) (:id . 69))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 152)\n  (:start . 145) (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 158)\n  (:start . 153) (:id . 71))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 168)\n  (:start . 159) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 180)\n  (:start . 173) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 188)\n  (:start . 181) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x39.6.1) (:span 84 87)))\n (:nscopes ((:id . :x39.6.1) (:span 81 120)))\n (:identifiers (:sid . :s39.6) (:did . :|91277630|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000371@unknown@formal@none@1@S@Surprisingly, multimers of kappa 1-kappa 3 can confer PMA inducibility on a heterologous promoter in a B (Raji), but not a T (HUT78) cell line.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "multimer") (:form . "multimers") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "1-kappa") (:form . "1-kappa") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 88)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HUT78") (:form . "HUT78") (:end . 131)\n  (:start . 126) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 71))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 142) (:start . 138)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x39.7.1) (:span 117 120)))\n (:nscopes ((:id . :x39.7.1) (:span 117 142)))\n (:identifiers (:sid . :s39.7) (:did . :|91277630|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000372@unknown@formal@none@1@S@However they are not functional on a truncated TNF-alpha promoter, indicating that promoter context and cell type specificity influence the PMA inducible function of these NF-kappa B binding sites.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "VBP") (:stem . "influence") (:form . "influence") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 180)\n  (:start . 172) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 182) (:start . 181)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 190)\n  (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x39.8.1) (:span 67 82)))\n (:ncues ((:id . :x39.8.2) (:span 17 20)))\n (:hscopes ((:id . :x39.8.1) (:span 67 196)))\n (:nscopes ((:id . :x39.8.2) (:span 17 65)))\n (:identifiers (:sid . :s39.8) (:did . :|91277630|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000373@unknown@formal@none@1@S@Towards a molecular understanding of T-cell differentiation.@(((:tag . "IN") (:stem . "towards") (:form . "Towards") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 59) (:start . 44) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s40.1) (:did . :|91282927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000374@unknown@formal@none@1@S@Lymphoid differentiation is one of the best studied examples of mammalian development.@(((:tag . "JJ") (:stem . "lymphoid") (:form . "Lymphoid") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s40.2) (:did . :|91282927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000375@unknown@formal@none@1@S@Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Hans") (:form . "Hans") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Clevers") (:form . "Clevers") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Michael") (:form . "Michael") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "Owen") (:form . "Owen") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 100) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 144) (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 161) (:start . 148) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 174) (:start . 170)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 182)\n  (:start . 175) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 206)\n  (:start . 201) (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 213)\n  (:start . 207) (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 219)\n  (:start . 214) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s40.3) (:did . :|91282927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000376@unknown@formal@none@1@S@Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "function") (:form . "functioning") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "'mast") (:form . "'master") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 155) (:start . 140) (:id . 64))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s40.4) (:did . :|91282927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000377@unknown@formal@none@1@S@Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 97) (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s41.1) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000378@unknown@formal@none@1@S@The macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 33) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 95) (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s41.2) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000380@unknown@formal@none@1@S@The present studies have examined the effects of M-CSF on potential signaling pathways involving expression of the jun and fos early response genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s41.4) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000381@unknown@formal@none@1@S@Low levels of c-jun transcripts were detectable in resting human peripheral blood monocytes.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s41.5) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000382@unknown@formal@none@1@S@Treatment of these cells with 10(3) units/ml human recombinant M-CSF was associated with rapid and transient increases in c-jun mRNA levels.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "10(3)") (:form . "10(3)") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "units/ml") (:form . "units/ml") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s41.6) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000383@unknown@formal@none@1@S@Nuclear run-on assays and mRNA stability studies demonstrated that M-CSF regulates c-jun expression by both an increase in transcription rate and a prolongation in the half-life of c-jun transcripts.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "prolongation") (:form . "prolongation") (:end . 160)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 177)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 186)\n  (:start . 181) (:id . 69))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 198)\n  (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s41.7) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000384@unknown@formal@none@1@S@M-CSF treatment was also associated with a rapid induction of the jun-B gene, although expression of this gene was prolonged compared to that of c-jun.@(((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "prolong") (:form . "prolonged") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s41.8) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000385@unknown@formal@none@1@S@We further demonstrate that M-CSF increases c-fos mRNA levels in human monocytes through control at both the transcriptional and posttranscriptional levels.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 124) (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 148) (:start . 129) (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 155)\n  (:start . 149) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s41.9) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000386@unknown@formal@none@1@S@Maximal induction of the c-fos gene was followed by that for the fos-B gene.@(((:tag . "JJ") (:stem . "maximal") (:form . "Maximal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fos-b") (:form . "fos-B") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s41.10) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000387@unknown@formal@none@1@S@Moreover, M-CSF-induced expression of the fos-related gene, fra-1, was delayed compared to that for both c-fos and fos-B.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "m-csf-induced") (:form . "M-CSF-induced")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "fos-related") (:form . "fos-related") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "fos-b") (:form . "fos-B") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s41.11) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000388@unknown@formal@none@1@S@Taken together, the results indicate that M-CSF treatment is associated with differential activation of multiple members of the jun/fos family and that expression of these genes could contribute to nuclear signaling mechanisms that regulate a specific program of monocyte differentiation.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "jun/fos") (:form . "jun/fos") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 183)\n  (:start . 178) (:id . 69))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 194)\n  (:start . 184) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 205)\n  (:start . 198) (:id . 72))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 215)\n  (:start . 206) (:id . 73))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 226)\n  (:start . 216) (:id . 74))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 231) (:start . 227)\n  (:id . 75))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 240)\n  (:start . 232) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 242) (:start . 241)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 251)\n  (:start . 243) (:id . 78))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 259)\n  (:start . 252) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 262) (:start . 260)\n  (:id . 80))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 271)\n  (:start . 263) (:id . 81))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 287) (:start . 272) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x41.12.1) (:span 178 183))\n  ((:id . :x41.12.2) (:span 28 41)))\n (:hscopes ((:id . :x41.12.1) (:span 178 287))\n  ((:id . :x41.12.2) (:span 28 287)))\n (:identifiers (:sid . :s41.12) (:did . :|91291720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000390@unknown@formal@none@1@S@A new homeobox gene, HB24, has been isolated from a human B-lymphocyte cDNA library.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HB24") (:form . "HB24") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 30) (:start . 27)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 44)\n  (:start . 36) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte") (:end . 70)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s42.2) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000391@unknown@formal@none@1@S@Northern blot analysis of polyadenylated RNA purified from activated human B cells revealed a single mRNA transcript of approximately 2.3 kb.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "polyadenylate") (:form . "polyadenylated")\n  (:end . 40) (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 133) (:start . 120) (:id . 60))\n ((:tag . "CD") (:stem . "2.3") (:form . "2.3") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s42.3) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000392@unknown@formal@none@1@S@Two cDNA clones were sequenced and provided 2,250 nucleotides (nt) of DNA sequence information.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "CD") (:stem . "2,250") (:form . "2,250") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nt") (:form . "nt") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s42.4) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000393@unknown@formal@none@1@S@There is a single methionine codon-initiated open reading frame of 1,458 nt in frame with a homeobox and a CAX repeat, and the open reading frame is predicted to encode a protein of 51,659 daltons.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "methionine") (:form . "methionine") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "codon-initiated") (:form . "codon-initiated")\n  (:end . 44) (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1,458") (:form . "1,458") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nt") (:form . "nt") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CAX") (:form . "CAX") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 131) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 145)\n  (:start . 140) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 158)\n  (:start . 149) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 168)\n  (:start . 162) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 178)\n  (:start . 171) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 75))\n ((:tag . "CD") (:stem . "51,659") (:form . "51,659") (:end . 188)\n  (:start . 182) (:id . 76))\n ((:tag . "NNS") (:stem . "dalton") (:form . "daltons") (:end . 196)\n  (:start . 189) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x42.5.1) (:span 149 158)))\n (:hscopes ((:id . :x42.5.1) (:span 123 196)))\n (:identifiers (:sid . :s42.5) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000394@unknown@formal@none@1@S@When the homeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged Drosophila homeodomain, H2.0, it was found to be 80 % identical.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homeodomain") (:form . "homeodomain") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "homeodomain") (:form . "homeodomains") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "RB") (:stem . "moderately") (:form . "moderately") (:end . 125)\n  (:start . 115) (:id . 61))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 173)\n  (:start . 167) (:id . 71))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 182)\n  (:start . 174) (:id . 72))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 193)\n  (:start . 183) (:id . 73))\n ((:tag . "NN") (:stem . "homeodomain") (:form . "homeodomain") (:end . 205)\n  (:start . 194) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "H2.0") (:form . "H2.0") (:end . 211) (:start . 207)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 77))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 219) (:start . 216)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 225)\n  (:start . 220) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 228) (:start . 226)\n  (:id . 81))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 231) (:start . 229)\n  (:id . 82))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 234) (:start . 232)\n  (:id . 83))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 236) (:start . 235)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 246)\n  (:start . 237) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s42.6) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000395@unknown@formal@none@1@S@The HB24 mRNA was absent or present at low levels in normal B and T lymphocytes;@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HB24") (:form . "HB24") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 79)\n  (:start . 68) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 80) (:start . 79)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x42.7.1) (:span 25 27)))\n (:hscopes ((:id . :x42.7.1) (:span 18 35)))\n (:identifiers (:sid . :s42.7) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000396@unknown@formal@none@1@S@however, with the appropriate activation signal HB24 mRNA was induced within several hours even in the presence of cycloheximide.@(((:tag . "RB") (:stem . "however") (:form . "however") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "HB24") (:form . "HB24") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s42.8) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000397@unknown@formal@none@1@S@Characterization of HB24 expression in lymphoid and select developing tissues was performed by in situ hybridization.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "select") (:form . "select") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s42.9) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000398@unknown@formal@none@1@S@Positive hybridization was found in thymus, tonsil, bone marrow, developing vessels, and in fetal brain.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tonsil") (:form . "tonsil") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "vessel") (:form . "vessels") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s42.10) (:did . :|91291757|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000400@unknown@formal@none@1@S@Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency.@(((:tag . "JJ") (:stem . "severe") (:form . "Severe") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "5-fluorouracil") (:form . "5-fluorouracil")\n  (:end . 21) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dihydropyrimidine") (:form . "dihydropyrimidine")\n  (:end . 61) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 75) (:start . 62) (:id . 48))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 86)\n  (:start . 76) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s43.1) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000401@unknown@formal@none@1@S@A potentially more common pharmacogenetic syndrome.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "pharmacogenetic") (:form . "pharmacogenetic")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 48)))@@@1@7@((:hcues ((:id . :x43.2.1) (:span 2 13)))\n (:hscopes ((:id . :x43.2.1) (:span 2 50)))\n (:identifiers (:sid . :s43.2) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000402@unknown@formal@none@1@S@This study describes the inheritance of a defect in pyrimidine catabolism and its association with drug-induced toxicity in a patient receiving 5-fluorouracil (FUra) as adjuvant chemotherapy for breast carcinoma.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inheritance") (:form . "inheritance") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pyrimidine") (:form . "pyrimidine") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "catabolism") (:form . "catabolism") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "drug-induced") (:form . "drug-induced") (:end . 111)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "VBG") (:stem . "receive") (:form . "receiving") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "5-fluorouracil") (:form . "5-fluorouracil")\n  (:end . 158) (:start . 144) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "FUra") (:form . "FUra") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "adjuvant") (:form . "adjuvant") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 190)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 201)\n  (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 211)\n  (:start . 202) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s43.3) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000403@unknown@formal@none@1@S@The study population included the affected patient (proband), nine of her blood relatives, and seven healthy volunteers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "proband") (:form . "proband") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "her") (:form . "her") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "relative") (:form . "relatives") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s43.4) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000404@unknown@formal@none@1@S@The activity of dihydropyrimidine dehydrogenase (DPD), the initial enzyme of pyrimidine ( and FUra) catabolism, in peripheral blood mononuclear cells was measured in each subject by a specific radiometric assay using FUra as the substrate.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dihydropyrimidine") (:form . "dihydropyrimidine")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DPD") (:form . "DPD") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pyrimidine") (:form . "pyrimidine") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FUra") (:form . "FUra") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "catabolism") (:form . "catabolism") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 143)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 162)\n  (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "subject") (:form . "subject") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 192)\n  (:start . 184) (:id . 74))\n ((:tag . "JJ") (:stem . "radiometric") (:form . "radiometric") (:end . 204)\n  (:start . 193) (:id . 75))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 210)\n  (:start . 205) (:id . 76))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 216) (:start . 211)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "FUra") (:form . "FUra") (:end . 221) (:start . 217)\n  (:id . 78))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 224) (:start . 222)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 80))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 238)\n  (:start . 229) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s43.5) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000405@unknown@formal@none@1@S@The proband had no detectable DPD activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proband") (:form . "proband") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "DPD") (:form . "DPD") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x43.6.1) (:span 16 18)))\n (:nscopes ((:id . :x43.6.1) (:span 16 42)))\n (:identifiers (:sid . :s43.6) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000406@unknown@formal@none@1@S@When enzyme levels in the proband and relatives were compared with that in controls, an autosomal recessive pattern of inheritance was demonstrated.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "proband") (:form . "proband") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "relative") (:form . "relatives") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "autosomal") (:form . "autosomal") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "recessive") (:form . "recessive") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inheritance") (:form . "inheritance") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 147)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s43.7) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000407@unknown@formal@none@1@S@This is the third patient with severe FUra toxicity secondary to an alteration in pyrimidine catabolism and the second from our clinic population suggesting that the frequency of this genetic defect may be greater than previously thought.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NNP") (:stem . "FUra") (:form . "FUra") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pyrimidine") (:form . "pyrimidine") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "catabolism") (:form . "catabolism") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "second") (:form . "second") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "clinic") (:form . "clinic") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 175)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 198)\n  (:start . 192) (:id . 72))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 213)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 218) (:start . 214)\n  (:id . 76))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 229)\n  (:start . 219) (:id . 77))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 237)\n  (:start . 230) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x43.8.1) (:span 199 202))\n  ((:id . :x43.8.2) (:span 146 156)))\n (:hscopes ((:id . :x43.8.1) (:span 199 237))\n  ((:id . :x43.8.2) (:span 146 237)))\n (:identifiers (:sid . :s43.8) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000408@unknown@formal@none@1@S@Monitoring DPD activity may be important in the management of patients experiencing severe toxicity secondary to FUra chemotherapy.@(((:tag . "VBG") (:stem . "monitor") (:form . "Monitoring") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dpd") (:form . "DPD") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "management") (:form . "management") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "VBG") (:stem . "experience") (:form . "experiencing") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FUra") (:form . "FUra") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x43.9.1) (:span 24 27)))\n (:hscopes ((:id . :x43.9.1) (:span 24 130)))\n (:identifiers (:sid . :s43.9) (:did . :|91292396|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000410@unknown@formal@none@1@S@We have cloned a group of cDNAs representing mRNAs that are rapidly induced following adherence of human monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 44)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s44.2) (:did . :|91292530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000411@unknown@formal@none@1@S@One of the induced transcripts (MAD-3) encodes a protein of 317 amino acids with one domain containing five tandem repeats of the cdc10/ankyrin motif, which is 60 % similar (46 % identical) to the ankyrin repeat region of the precursor of NF-kappa B/KBF1 p50.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MAD-3") (:form . "MAD-3") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . 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"ankyrin") (:form . "ankyrin") (:end . 204)\n  (:start . 197) (:id . 81))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 211)\n  (:start . 205) (:id . 82))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 218)\n  (:start . 212) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 85))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 235)\n  (:start . 226) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 247)\n  (:start . 239) (:id . 88))\n ((:tag . "NNP") (:stem . "B/KBF1") (:form . "B/KBF1") (:end . 254)\n  (:start . 248) (:id . 89))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 258) (:start . 255)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5000412@unknown@formal@none@1@S@The C-terminus has a putative protein kinase C phosphorylation site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C-terminus") (:form . "C-terminus") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x44.4.1) (:span 21 29)))\n (:hscopes ((:id . :x44.4.1) (:span 21 67)))\n (:identifiers (:sid . :s44.4) (:did . :|91292530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000413@unknown@formal@none@1@S@In vitro translated MAD-3 protein was found to specifically inhibit the DNA-binding activity of the p50/p65 NF-kappa B complex but not that of the p50/p50 KBF1 factor or of other DNA-binding proteins.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "MAD-3") (:form . "MAD-3") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 190)\n  (:start . 179) (:id . 72))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 199)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x44.5.1) (:span 131 134)))\n (:nscopes ((:id . :x44.5.1) (:span 131 199)))\n (:identifiers (:sid . :s44.5) (:did . :|91292530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000414@unknown@formal@none@1@S@The MAD-3 cDNA encodes an I kappa B-like protein that is likely to be involved in regulation of transcriptional responses to NF-kappa B, including adhesion-dependent pathways of monocyte activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MAD-3") (:form . "MAD-3") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 111) (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 146)\n  (:start . 137) (:id . 66))\n ((:tag . "JJ") (:stem . "adhesion-dependent") (:form . "adhesion-dependent")\n  (:end . 165) (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 197)\n  (:start . 187) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x44.6.1) (:span 57 63)))\n (:hscopes ((:id . :x44.6.1) (:span 49 197)))\n (:identifiers (:sid . :s44.6) (:did . :|91292530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000415@unknown@formal@none@1@S@Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.@(((:tag . "JJ") (:stem . "reactive") (:form . "Reactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s45.1) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000416@unknown@formal@none@1@S@Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes.@(((:tag . "NN") (:stem . "hydrogen") (:form . "Hydrogen") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "radical") (:form . "radicals") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 86)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s45.2) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000417@unknown@formal@none@1@S@In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "micromolar") (:form . "micromolar") (:end . 38)\n  (:start . 28) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 53) (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s45.3) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000418@unknown@formal@none@1@S@The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 161)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s45.4) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000420@unknown@formal@none@1@S@NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 105) (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 176) (:start . 163) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 196) (:start . 178) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 207)\n  (:start . 201) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s45.6) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000421@unknown@formal@none@1@S@This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 164)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x45.7.1) (:span 100 105)) ((:id . :x45.7.2) (:span 34 41))\n  ((:id . :x45.7.3) (:span 5 13)))\n (:hscopes ((:id . :x45.7.1) (:span 100 171)) ((:id . :x45.7.2) (:span 34 99))\n  ((:id . :x45.7.3) (:span 5 171)))\n (:identifiers (:sid . :s45.7) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000422@unknown@formal@none@1@S@ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B.@(((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x45.8.1) (:span 53 55)) ((:id . :x45.8.2) (:span 4 10)))\n (:hscopes ((:id . :x45.8.1) (:span 44 66)) ((:id . :x45.8.2) (:span 0 130)))\n (:identifiers (:sid . :s45.8) (:did . :|91293101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000423@unknown@formal@none@1@S@HTLV-1 Tax induces expression of various immediate early serum responsive genes.@(((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s46.1) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000424@unknown@formal@none@1@S@Human T-cell leukemia virus type 1 (HTLV-1) is an etiological agent of adult T-cell leukemia (ATL).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "etiological") (:form . "etiological") (:end . 61)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s46.2) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000425@unknown@formal@none@1@S@We showed here by mobility-shift assay that T-cell lines transformed with the virus contained high levels of AP-1 activities.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mobility-shift") (:form . "mobility-shift")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s46.3) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000426@unknown@formal@none@1@S@Consistent with this result, these cell lines expressed increased levels of mRNAs encoding the AP-1 proteins, c-Fos, Fra-1, c-Jun, JunB, and JunD.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "fra-1") (:form . "Fra-1") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 145) (:start . 141)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s46.4) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000427@unknown@formal@none@1@S@Previously, transcription of the c-fos gene has been reported to be transactivated by the viral transcription factor, Tax1.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 82) (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Tax1") (:form . "Tax1") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s46.5) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000428@unknown@formal@none@1@S@By using the human T-cell line (JPX-9), in which expression of the Tax1 is inducible, we showed that expression of mRNAs for Fra-1, c-Jun, and JunD was also transactivated by Tax1.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "JPX-9") (:form . "JPX-9") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tax1") (:form . "Tax1") (:end . 71) (:start . 67)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 84)\n  (:start . 75) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 88) (:start . 86)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 95) (:start . 89)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 120)\n  (:start . 115) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 67))\n ((:tag . "NN") (:stem . "fra-1") (:form . "Fra-1") (:end . 130)\n  (:start . 125) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 137)\n  (:start . 132) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 147) (:start . 143)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 151) (:start . 148)\n  (:id . 74))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 156) (:start . 152)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 171) (:start . 157) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Tax1") (:form . "Tax1") (:end . 179) (:start . 175)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s46.6) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000430@unknown@formal@none@1@S@The Tax1-inducible transcription factors identified here are encoded by the members of immediate early genes under the control of growth signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tax1-inducible") (:form . "Tax1-inducible")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 32) (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 51)\n  (:start . 41) (:id . 46))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 56) (:start . 52)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 68)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s46.8) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000431@unknown@formal@none@1@S@Thus , Tax1 was suggested to replace growth signals, at least in part, by this mechanism.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Tax1") (:form . "Tax1") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "replace") (:form . "replace") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 78) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 88)\n  (:start . 79) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x46.9.1) (:span 16 25)))\n (:hscopes ((:id . :x46.9.1) (:span 7 88)))\n (:identifiers (:sid . :s46.9) (:did . :|91296379|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000432@unknown@formal@none@1@S@Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types.@(((:tag . "NN") (:stem . "contribution") (:form . "Contribution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 103) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 151)\n  (:start . 145) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 166)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s47.1) (:did . :|91303691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000433@unknown@formal@none@1@S@Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1, lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat (LTR), proviruses containing reconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation.@(((:tag . "VBG") (:stem . "start") (:form . "Starting") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "replication-incompetent")\n  (:form . "replication-incompetent") (:end . 39) (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 49)\n  (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "clone") (:form . 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"elements") (:end . 298)\n  (:start . 290) (:id . 88))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 303) (:start . 299)\n  (:id . 89))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 313)\n  (:start . 304) (:id . 90))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 317) (:start . 314)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 327)\n  (:start . 318) (:id . 92))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 331) (:start . 328)\n  (:id . 93))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 337)\n  (:start . 332) (:id . 94))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 346)\n  (:start . 338) (:id . 95))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 349) (:start . 347)\n  (:id . 96))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 357)\n  (:start . 350) (:id . 97))\n ((:tag . "NN") (:stem . "virus") (:form . 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5000434@unknown@formal@none@1@S@Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human T-cell types depending on which element ( s ) was present in the LTR.@(((:tag . "NN") (:stem . "virus") (:form . "Virus") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "stock") (:form . "stocks") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "continuum") (:form . "continuum") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "capacity") (:form . "capacities") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 105)\n  (:start . 96) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 118)\n  (:start . 112) (:id . 57))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 124)\n  (:start . 119) (:id . 58))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 143)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s47.3) (:did . :|91303691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000435@unknown@formal@none@1@S@For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements ( and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication (peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat) was observed.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "proviral") (:form . 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5000436@unknown@formal@none@1@S@Of note was the associated emergence of second-site LTR revertants which involved an alteration of the TATA box.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "second-site") (:form . "second-site") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "revertant") (:form . "revertants") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "involve") (:form . "involved") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s47.5) (:did . :|91303691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000437@unknown@formal@none@1@S@These results suggest that the human immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different T-cell types and is capable of changing depending on the particular combination of transcriptional factors present.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 53) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "possess") (:form . "possesses") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "redundancy") (:form . "redundancy") (:end . 102)\n  (:start . 92) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "VBZ") (:stem . "ensure") (:form . "ensures") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 134)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 147)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 154)\n  (:start . 148) (:id . 62))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 160)\n  (:start . 155) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 175)\n  (:start . 168) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "change") (:form . "changing") (:end . 187)\n  (:start . 179) (:id . 68))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 197)\n  (:start . 188) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 215)\n  (:start . 205) (:id . 72))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 227)\n  (:start . 216) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 246) (:start . 231) (:id . 75))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 254)\n  (:start . 247) (:id . 76))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 262)\n  (:start . 255) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x47.6.1) (:span 14 21)))\n (:hscopes ((:id . :x47.6.1) (:span 14 262)))\n (:identifiers (:sid . :s47.6) (:did . :|91303691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000438@unknown@formal@none@1@S@Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.@(((:tag . "NN") (:stem . "enhancement") (:form . "Enhancement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 37) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "1,25-dihydroxycholecalciferol")\n  (:form . "1,25-dihydroxycholecalciferol") (:end . 103) (:start . 74)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s48.1) (:did . :|91319738|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000440@unknown@formal@none@1@S@We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "1,25-dihydroxycholecalciferol")\n  (:form . "1,25-dihydroxycholecalciferol") (:end . 49) (:start . 20)\n  (:id . 45))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 51) (:start . 50)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "1,25-(OH)2D3") (:form . "1,25-(OH)2D3") (:end . 63)\n  (:start . 51) (:id . 47))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 64) (:start . 63)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 89)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "NN") (:stem . "monocyte-") (:form . "monocyte-") (:end . 102)\n  (:start . 93) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lymphocyte-tropic") (:form . "lymphocyte-tropic")\n  (:end . 124) (:start . 107) (:id . 55))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 132)\n  (:start . 125) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 141)\n  (:start . 136) (:id . 58))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 144) (:start . 142)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "VB") (:stem . "10,000-fold") (:form . "10,000-fold") (:end . 159)\n  (:start . 148) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 62))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 171)\n  (:start . 163) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 182)\n  (:start . 177) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 194)\n  (:start . 184) (:id . 67))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 200)\n  (:start . 195) (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 210)\n  (:start . 201) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "unfractionated") (:form . "unfractionated")\n  (:end . 230) (:start . 216) (:id . 72))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 241)\n  (:start . 231) (:id . 73))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 247)\n  (:start . 242) (:id . 74))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 259)\n  (:start . 248) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 265)\n  (:start . 260) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s48.3) (:did . :|91319738|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000441@unknown@formal@none@1@S@1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date.@(((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s48.4) (:did . :|91319738|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000442@unknown@formal@none@1@S@Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor.@(((:tag . "NNS") (:stem . "precursor") (:form . "Precursors") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 51)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 65)\n  (:start . 55) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 74)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 117) (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 126)\n  (:start . 118) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 155)\n  (:start . 144) (:id . 61))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 166)\n  (:start . 156) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 172)\n  (:start . 167) (:id . 63))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 184)\n  (:start . 173) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 198)\n  (:start . 188) (:id . 66))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 208)\n  (:start . 199) (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 213) (:start . 209)\n  (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 222)\n  (:start . 214) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x48.5.1) (:span 128 138)))\n (:hscopes ((:id . :x48.5.1) (:span 128 222)))\n (:identifiers (:sid . :s48.5) (:did . :|91319738|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000443@unknown@formal@none@1@S@These studies may have important implications for the design of effective therapy of HIV-1 infection.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x48.6.1) (:span 14 17)))\n (:hscopes ((:id . :x48.6.1) (:span 14 100)))\n (:identifiers (:sid . :s48.6) (:did . :|91319738|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000444@unknown@formal@none@1@S@Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s49.1) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000445@unknown@formal@none@1@S@HIV-1 proviral DNA contains two binding sites for the transcription factor NF-kappa B.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s49.2) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000446@unknown@formal@none@1@S@HIV-1-infected individuals have , on average, abnormally high levels of tumour necrosis factor alpha (TNF alpha) and abnormally low plasma cysteine levels.@(((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 26)\n  (:start . 15) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "abnormally") (:form . "abnormally") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "RB") (:stem . "abnormally") (:form . "abnormally") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 138)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s49.3) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000447@unknown@formal@none@1@S@We therefore investigated the effects of cysteine and related thiols on HIV-1 replication and NF-kappa B expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "thiol") (:form . "thiols") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s49.4) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000448@unknown@formal@none@1@S@The experiments in this report show that cysteine or N-acetylcysteine (NAC) raise the intracellular glutathione ( GSH ) level and inhibit HIV-1 replication in persistently infected Molt-4 and U937 cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 69) (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "raise") (:form . "raise") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 99) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "RB") (:stem . "persistently") (:form . "persistently") (:end . 171)\n  (:start . 159) (:id . 68))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 180)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "molt-4") (:form . "Molt-4") (:end . 187)\n  (:start . 181) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s49.5) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000450@unknown@formal@none@1@S@Cysteine and NAC also inhibit NF-kappa B activity as determined by electrophoretic mobility shift assays and chloramphenicol acetyl-transferase (CAT) gene expression under control of NF-kappa B binding sites in uninfected cells.@(((:tag . "NNP") (:stem . "Cysteine") (:form . "Cysteine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 82) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 124) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "acetyl-transferase") (:form . "acetyl-transferase")\n  (:end . 143) (:start . 125) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 191)\n  (:start . 183) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 201)\n  (:start . 194) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 207)\n  (:start . 202) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 221)\n  (:start . 211) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 227)\n  (:start . 222) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s49.7) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000451@unknown@formal@none@1@S@This suggests that the cysteine deficiency in HIV-1-infected individuals may cause an over-expression of NF-kappa B-dependent genes and enhance HIV-1 replication.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 60) (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 72)\n  (:start . 61) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "over-expression") (:form . "over-expression")\n  (:end . 101) (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 125)\n  (:start . 114) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 143)\n  (:start . 136) (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 161)\n  (:start . 150) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x49.8.1) (:span 73 76)) ((:id . :x49.8.2) (:span 5 13)))\n (:hscopes ((:id . :x49.8.1) (:span 73 161)) ((:id . :x49.8.2) (:span 5 161)))\n (:identifiers (:sid . :s49.8) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000452@unknown@formal@none@1@S@NAC may be considered for the treatment of HIV-1-infected individuals.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 57) (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x49.9.1) (:span 4 7)))\n (:hscopes ((:id . :x49.9.1) (:span 0 69)))\n (:identifiers (:sid . :s49.9) (:did . :|91321794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000453@unknown@formal@none@1@S@Glucocorticoid receptors in systemic lupus erythematosus.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "erythematosus") (:form . "erythematosus")\n  (:end . 56) (:start . 43) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s50.1) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000454@unknown@formal@none@1@S@Glucocorticosteroids remain the major treatment modality for systemic lupus erythematosus (SLE), but their mechanism of action is unclear.@(((:tag . "NNS") (:stem . "glucocorticosteroid")\n  (:form . "Glucocorticosteroids") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 27)\n  (:start . 21) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 37) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "modality") (:form . "modality") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 75) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "erythematosus") (:form . "erythematosus")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s50.2) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000455@unknown@formal@none@1@S@Over the past decade it has become clear that glucocorticosteroid receptors play a significant role in the mechanism of glucocorticosteroid action.@(((:tag . "IN") (:stem . "over") (:form . "Over") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "past") (:form . "past") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "decade") (:form . "decade") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "become") (:form . "become") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 65) (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 139) (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s50.3) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000456@unknown@formal@none@1@S@We studied glucocorticosteroid receptor density and affinity on peripheral blood mononuclear cells by the glucocorticosteroid binding assay in 33 patients with SLE who had taken no glucocorticosteroid for the previous 6 months and in 32 healthy controls.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 30) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 92)\n  (:start . 81) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 125) (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 133)\n  (:start . 126) (:id . 57))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 139)\n  (:start . 134) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 163) (:start . 160)\n  (:id . 63))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 177)\n  (:start . 172) (:id . 66))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 200) (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 217)\n  (:start . 209) (:id . 71))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 219) (:start . 218)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 226)\n  (:start . 220) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 75))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 236) (:start . 234)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 244)\n  (:start . 237) (:id . 77))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 253)\n  (:start . 245) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x50.4.1) (:span 178 180)))\n (:nscopes ((:id . :x50.4.1) (:span 178 253)))\n (:identifiers (:sid . :s50.4) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000457@unknown@formal@none@1@S@Patients ' disease activity was measured by the SLE Disease Activity Index (SLEDAI).@(((:tag . "NNPS") (:stem . "Patient") (:form . "Patients") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Disease") (:form . "Disease") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NNP") (:stem . "Activity") (:form . "Activity") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "Index") (:form . "Index") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SLEDAI") (:form . "SLEDAI") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s50.5) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000458@unknown@formal@none@1@S@Glucocorticosteroid receptors on leukocytes of patients with SLE were significantly higher than in healthy controls (4419 ± 306 vs 3369 ± 196, p less than 0.005).@(((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "Glucocorticosteroid") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 29)\n  (:start . 20) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 90) (:start . 84)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 106)\n  (:start . 99) (:id . 55))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 115)\n  (:start . 107) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 57))\n ((:tag . "CD") (:stem . "4419") (:form . "4419") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "CD") (:stem . "306") (:form . "306") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "CC") (:stem . "vs") (:form . "vs") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "CD") (:stem . "3369") (:form . "3369") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "CD") (:stem . "196") (:form . "196") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "CD") (:stem . "0.005") (:form . "0.005") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s50.6) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000460@unknown@formal@none@1@S@There was no correlation between glucocorticosteroid receptor number and SLE disease activity.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 52) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sle") (:form . "SLE") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x50.8.1) (:span 10 12)))\n (:nscopes ((:id . :x50.8.1) (:span 10 93)))\n (:identifiers (:sid . :s50.8) (:did . :|91325181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000461@unknown@formal@none@1@S@[Changes in leucocytic estrogen receptor levels in patients with gynecomastia]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 8)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "leucocytic") (:form . "leucocytic") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gynecomastia") (:form . "gynecomastia") (:end . 77)\n  (:start . 65) (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s51.1) (:did . :|91339573|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000462@unknown@formal@none@1@S@The number of estrogen receptor (ER) in human peripheral leucocytes in 13 men with gynecomastia were measured by radioligand binding method.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 56)\n  (:start . 46) (:id . 52))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "man") (:form . "men") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gynecomastia") (:form . "gynecomastia") (:end . 95)\n  (:start . 83) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "radioligand") (:form . "radioligand") (:end . 124)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s51.2) (:did . :|91339573|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000463@unknown@formal@none@1@S@The results were compared with those of 13 sex- and age-matched healthy subjects.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sex-") (:form . "sex-") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "age-matched") (:form . "age-matched") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s51.3) (:did . :|91339573|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000464@unknown@formal@none@1@S@It was found that the number of ER in leucocytes was significantly increased in gynecomastia (Rs of leucocytes were 1054 ± 254 sites/cell).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 48)\n  (:start . 38) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 66) (:start . 53) (:id . 53))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gynecomastia") (:form . "gynecomastia") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "r") (:form . "Rs") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1054") (:form . "1054") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "IN") (:stem . "±") (:form . "±") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CD") (:stem . "254") (:form . "254") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "sites/cell") (:form . "sites/cell") (:end . 137)\n  (:start . 127) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s51.4) (:did . :|91339573|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000465@unknown@formal@none@1@S@It suggested that increase of ER levels play an important role in the pathogenesis of gynecomastia.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 82)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gynecomastia") (:form . "gynecomastia") (:end . 98)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x51.5.1) (:span 3 12)))\n (:hscopes ((:id . :x51.5.1) (:span 3 98)))\n (:identifiers (:sid . :s51.5) (:did . :|91339573|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000466@unknown@formal@none@1@S@[Changes in levels of leucocytic estrogen receptor in patients with menopausal type II diabetes and its significance]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 8)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "leucocytic") (:form . "leucocytic") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "menopausal") (:form . "menopausal") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "diabete") (:form . "diabetes") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 116)\n  (:start . 104) (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s52.1) (:did . :|91347784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000467@unknown@formal@none@1@S@The number of estrogen receptors (ER) in human peripheral leucocytes in 12 women with menopausal type II diabetes was measured with radio-ligand binding method.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "menopausal") (:form . "menopausal") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "diabete") (:form . "diabetes") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "radio-ligand") (:form . "radio-ligand") (:end . 144)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s52.2) (:did . :|91347784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000468@unknown@formal@none@1@S@The results were compared with those of 12 menopausal women without diabetes and 12 normal women of childbearing age.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "menopausal") (:form . "menopausal") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "diabete") (:form . "diabetes") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "childbeare") (:form . "childbearing") (:end . 112)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x52.3.1) (:span 60 67)))\n (:nscopes ((:id . :x52.3.1) (:span 60 76)))\n (:identifiers (:sid . :s52.3) (:did . :|91347784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000470@unknown@formal@none@1@S@Our data indicate that decrease of ER level in leukocytes may be related to the pathogenesis of type II diabetes in menopausal period.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 92)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "diabete") (:form . "diabetes") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "menopausal") (:form . "menopausal") (:end . 126)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x52.5.1) (:span 58 61)) ((:id . :x52.5.2) (:span 9 22)))\n (:hscopes ((:id . :x52.5.1) (:span 58 133)) ((:id . :x52.5.2) (:span 9 133)))\n (:identifiers (:sid . :s52.5) (:did . :|91347784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000471@unknown@formal@none@1@S@Lymphocyte glucocorticoid receptor binding during depression and after clinical recovery.@(((:tag . "NNP") (:stem . "Lymphocyte") (:form . "Lymphocyte") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 25) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 49)\n  (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "depression") (:form . "depression") (:end . 60)\n  (:start . 50) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 88)\n  (:start . 80) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s53.1) (:did . :|91349414|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000472@unknown@formal@none@1@S@Lymphocyte glucocorticoid receptor binding parameters were studied in 15 severely depressed patients during depression and after clinical recovery, and in 15 healthy controls.@(((:tag . "NNP") (:stem . "Lymphocyte") (:form . "Lymphocyte") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 25) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 45))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 53)\n  (:start . 43) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 66)\n  (:start . 59) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 49))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "JJ") (:stem . "depressed") (:form . "depressed") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 100)\n  (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 107)\n  (:start . 101) (:id . 54))\n ((:tag . "NN") (:stem . "depression") (:form . "depression") (:end . 118)\n  (:start . 108) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 128)\n  (:start . 123) (:id . 57))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 137)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 146)\n  (:start . 138) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 157) (:start . 155)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 165)\n  (:start . 158) (:id . 64))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s53.2) (:did . :|91349414|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000473@unknown@formal@none@1@S@There was no difference in glucocorticoid receptor number or affinity between depressed patients and recovered or control subjects.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 41) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "JJ") (:stem . "depressed") (:form . "depressed") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "recover") (:form . "recovered") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x53.3.1) (:span 58 60)))\n (:ncues ((:id . :x53.3.2) (:span 10 12)))\n (:hscopes ((:id . :x53.3.1) (:span 27 69)))\n (:nscopes ((:id . :x53.3.2) (:span 10 130)))\n (:identifiers (:sid . :s53.3) (:did . :|91349414|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000474@unknown@formal@none@1@S@Afternoon ACTH and cortisol concentrations did not differ significantly between the three groups.@(((:tag . "NN") (:stem . "afternoon") (:form . "Afternoon") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acth") (:form . "ACTH") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 42) (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x53.4.1) (:span 47 50)))\n (:nscopes ((:id . :x53.4.1) (:span 47 96)))\n (:identifiers (:sid . :s53.4) (:did . :|91349414|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000475@unknown@formal@none@1@S@No relationship could be established between glucocorticoid receptor binding and antidepressant medication.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 59) (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "antidepressant") (:form . "antidepressant")\n  (:end . 95) (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "medication") (:form . "medication") (:end . 106)\n  (:start . 96) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x53.5.1) (:span 0 2)))\n (:nscopes ((:id . :x53.5.1) (:span 0 106)))\n (:identifiers (:sid . :s53.5) (:did . :|91349414|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000476@unknown@formal@none@1@S@These data support the view of an impaired ligand-induced plasticity of glucocorticoid receptor regulation rather than the hypothesis of decreased glucocorticoid receptor numbers during depression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "ligand-induced") (:form . "ligand-induced")\n  (:end . 57) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "plasticity") (:form . "plasticity") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 86) (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 113)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 133)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 146)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 161) (:start . 147) (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 170)\n  (:start . 162) (:id . 63))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 178)\n  (:start . 171) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 185)\n  (:start . 179) (:id . 65))\n ((:tag . "NN") (:stem . "depression") (:form . "depression") (:end . 196)\n  (:start . 186) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x53.6.2) (:span 11 18)))\n (:ncues ((:id . :x53.6.1) (:span 107 118)))\n (:hscopes ((:id . :x53.6.2) (:span 11 196)))\n (:nscopes ((:id . :x53.6.1) (:span 107 196)))\n (:identifiers (:sid . :s53.6) (:did . :|91349414|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000477@unknown@formal@none@1@S@Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A [see comments]@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FK-506") (:form . "FK-506") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s54.1) (:did . :|91351285|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000478@unknown@formal@none@1@S@Cyclosporin A and FK506 inhibit T- and B-cell activation and other processes essential to an effective immune response.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "t-") (:form . "T-") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s54.2) (:did . :|91351285|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000480@unknown@formal@none@1@S@The putative intracellular receptors for FK506 and cyclosporin are cis-trans prolyl isomerases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cis-trans") (:form . "cis-trans") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "prolyl") (:form . "prolyl") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "isomeras") (:form . "isomerases") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x54.4.1) (:span 4 12)))\n (:hscopes ((:id . :x54.4.1) (:span 4 62)))\n (:identifiers (:sid . :s54.4) (:did . :|91351285|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000481@unknown@formal@none@1@S@Binding of the drug inhibits isomerase activity, but studies with other prolyl isomerase inhibitors and analysis of cyclosporin-resistant mutants in yeast suggest that the effects of the drug result from the formation of an inhibitory complex between the drug and isomerase, and not from inhibition of isomerase activity.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "isomerase") (:form . "isomerase") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . 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5000482@unknown@formal@none@1@S@A transcription factor, NF-AT, which is essential for early T-cell gene activation, seems to be a specific target of cyclosporin A and FK506 action because transcription directed by this protein is blocked in T cells treated with these drugs, with little or no effect on other transcription factors such as AP-1 and NF-kappa B.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . 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5000484@unknown@formal@none@1@S@FK506 and cyclosporin A block translocation of the cytoplasmic component without affecting synthesis of the nuclear subunit.@(((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x54.8.1) (:span 73 80)))\n (:nscopes ((:id . :x54.8.1) (:span 73 123)))\n (:identifiers (:sid . :s54.8) (:did . :|91351285|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000485@unknown@formal@none@1@S@Regulation of M-CSF expression by M-CSF: role of protein kinase C and transcription factor NF kappa B.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s55.1) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000486@unknown@formal@none@1@S@Macrophage-colony-stimulating factor (M-CSF), also referred to as CSF-1, regulates the survival, growth, differentiation and functional activity of monocytes by binding to a single class of high-affinity cell surface receptors, known to be the product of the c-fms protooncogene.@(((:tag . "JJ") (:stem . "macrophage-colony-stimulating")\n  (:form . "Macrophage-colony-stimulating") (:end . 29) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 43) (:start . 38)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "csf-1") (:form . "CSF-1") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 120) (:start . 105) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 168)\n  (:start . 161) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 180)\n  (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 186)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 203) (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 208) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 226)\n  (:start . 217) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 227) (:start . 226)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 233)\n  (:start . 228) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 236) (:start . 234)\n  (:id . 79))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 239) (:start . 237)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 243) (:start . 240)\n  (:id . 81))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 251)\n  (:start . 244) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 254) (:start . 252)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 258) (:start . 255)\n  (:id . 84))\n ((:tag . "NN") (:stem . "c-fms") (:form . "c-fms") (:end . 264)\n  (:start . 259) (:id . 85))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 278) (:start . 265) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s55.2) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000487@unknown@formal@none@1@S@The detection of both M-CSF and c-fms expression by cells of the monocyte lineage has suggested that M-CSF may act by an autocrine mechanism.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fms") (:form . "c-fms") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 130)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x55.3.1) (:span 107 110)) ((:id . :x55.3.2) (:span 86 95)))\n (:hscopes ((:id . :x55.3.1) (:span 107 140))\n  ((:id . :x55.3.2) (:span 86 140)))\n (:identifiers (:sid . :s55.3) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000488@unknown@formal@none@1@S@Interestingly, it has been shown that M-CSF can induce the expression of its own gene.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s55.4) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000490@unknown@formal@none@1@S@To date, little is known about the intracellular pathway of M-CSF signal transduction.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 48) (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s55.6) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000491@unknown@formal@none@1@S@We have therefore investigated the changes in protein kinase C (PKC) activity upon exposure of monocytes to M-CSF.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s55.7) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000492@unknown@formal@none@1@S@We show that M-CSF activates and translocates PKC.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "translocate") (:form . "translocates") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s55.8) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000493@unknown@formal@none@1@S@Inhibition of PKC by the isoquinoline derivative H7 abolishes induction of M-CSF by M-CSF.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "isoquinoline") (:form . "isoquinoline") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "derivative") (:form . "derivative") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "h7") (:form . "H7") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s55.9) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000494@unknown@formal@none@1@S@Furthermore, activation of PKC was pertussis-toxin-sensitive and was associated with the detection of an NF kappa B protein in nuclear extracts of M-CSF-induced blood monocytes but not in monocytes exposed to medium treatment only.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pertussis-toxin-sensitive")\n  (:form . "pertussis-toxin-sensitive") (:end . 60) (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "m-csf-induced") (:form . "M-CSF-induced")\n  (:end . 160) (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 166)\n  (:start . 161) (:id . 66))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 176)\n  (:start . 167) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 197)\n  (:start . 188) (:id . 71))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 205)\n  (:start . 198) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 215)\n  (:start . 209) (:id . 74))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 225)\n  (:start . 216) (:id . 75))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 230) (:start . 226)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x55.10.1) (:span 181 184)))\n (:nscopes ((:id . :x55.10.1) (:span 181 230)))\n (:identifiers (:sid . :s55.10) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000495@unknown@formal@none@1@S@The results suggest that M-CSF induction of M-CSF involves G proteins, PKC and NF kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x55.11.1) (:span 12 19)))\n (:hscopes ((:id . :x55.11.1) (:span 12 89)))\n (:identifiers (:sid . :s55.11) (:did . :|91354520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000496@unknown@formal@none@1@S@NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 129)\n  (:start . 123) (:id . 64))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "Ca(2+)-regulated") (:form . "Ca(2+)-regulated")\n  (:end . 153) (:start . 137) (:id . 68))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 161)\n  (:start . 154) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s56.1) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000497@unknown@formal@none@1@S@NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 130) (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s56.2) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000498@unknown@formal@none@1@S@In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 20)\n  (:start . 12) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 35)\n  (:start . 26) (:id . 49))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s56.3) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000500@unknown@formal@none@1@S@We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 88)\n  (:start . 80) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 97)\n  (:start . 89) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s56.5) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000501@unknown@formal@none@1@S@Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not.@(((:tag . "NNP") (:stem . "Phorbol") (:form . "Phorbol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x56.6.1) (:span 90 93)))\n (:nscopes ((:id . :x56.6.1) (:span 65 93)))\n (:identifiers (:sid . :s56.6) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000502@unknown@formal@none@1@S@Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "staurosporin") (:form . "staurosporin") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s56.7) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000503@unknown@formal@none@1@S@TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x56.8.1) (:span 62 65)) ((:id . :x56.8.2) (:span 14 17)))\n (:nscopes ((:id . :x56.8.1) (:span 47 94)) ((:id . :x56.8.2) (:span 14 42)))\n (:identifiers (:sid . :s56.8) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000504@unknown@formal@none@1@S@Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x56.9.1) (:span 30 33)))\n (:nscopes ((:id . :x56.9.1) (:span 30 69)))\n (:identifiers (:sid . :s56.9) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000505@unknown@formal@none@1@S@Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "alpha-induced") (:form . "alpha-induced")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "signal-mediating") (:form . "signal-mediating")\n  (:end . 108) (:start . 92) (:id . 59))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 70))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 163)\n  (:start . 157) (:id . 71))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 169) (:start . 167)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "Ca(2+)-regulated") (:form . "Ca(2+)-regulated")\n  (:end . 186) (:start . 170) (:id . 75))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 194)\n  (:start . 187) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x56.10.1) (:span 74 78)))\n (:nscopes ((:id . :x56.10.1) (:span 6 194)))\n (:identifiers (:sid . :s56.10) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000506@unknown@formal@none@1@S@Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "acidification") (:form . "acidification")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "VBD") (:stem . "facilitate") (:form . "facilitated") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "NNP") (:stem . "B/I") (:form . "B/I") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 177)\n  (:start . 165) (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 195)\n  (:start . 186) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 208)\n  (:start . 200) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 210) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 224) (:start . 211) (:id . 75))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 229) (:start . 225)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x56.11.1) (:span 178 185)))\n (:nscopes ((:id . :x56.11.1) (:span 178 229)))\n (:identifiers (:sid . :s56.11) (:did . :|91355651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000507@unknown@formal@none@1@S@NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 93)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s57.1) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000508@unknown@formal@none@1@S@The effect of constitutive Tax expression on the interaction of NF-kappa B with its recognition sequence and on NF-kappa B-dependent gene expression was examined in T lymphoid Jurkat cell lines (19D and 9J) stably transformed with a Tax expression vector.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 161)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 175)\n  (:start . 167) (:id . 68))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "19d") (:form . "19D") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . "NN") (:stem . "9j") (:form . "9J") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 76))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 213)\n  (:start . 207) (:id . 77))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 225)\n  (:start . 214) (:id . 78))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 230) (:start . 226)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 232) (:start . 231)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 236) (:start . 233)\n  (:id . 81))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 247)\n  (:start . 237) (:id . 82))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 254)\n  (:start . 248) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s57.2) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000510@unknown@formal@none@1@S@In Jurkat and NC2.10 induction with phorbol esters resulted in the appearance of new DNA binding proteins of 85 , 75 , and 54 kDa, whereas in Tax expressing cells the 85-kDa protein and a 92-kDa DNA binding protein were constitutively induced.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NC2.10") (:form . "NC2.10") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "CD") (:stem . "85") (:form . "85") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "CD") (:stem . "54") (:form . "54") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 138)\n  (:start . 131) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 145) (:start . 142)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expressing") (:form . "expressing") (:end . 156)\n  (:start . 146) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 162)\n  (:start . 157) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "85-kda") (:form . "85-kDa") (:end . 173)\n  (:start . 167) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "92-kda") (:form . "92-kDa") (:end . 194)\n  (:start . 188) (:id . 78))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 198) (:start . 195)\n  (:id . 79))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 206)\n  (:start . 199) (:id . 80))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 214)\n  (:start . 207) (:id . 81))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 219) (:start . 215)\n  (:id . 82))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 234) (:start . 220) (:id . 83))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 242)\n  (:start . 235) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s57.4) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000511@unknown@formal@none@1@S@Expression of Tax protein in 19D and 9J resulted in transcription of the endogenous NF-kappa B-dependent granulocyte-macrophage colony stimulating factor gene and increased basal level expression of transfected NF-kappa B-regulated promoters.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "19d") (:form . "19D") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "9j") (:form . "9J") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 127) (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 146)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 153)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 158) (:start . 154)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 172)\n  (:start . 163) (:id . 64))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 178)\n  (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 184)\n  (:start . 179) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 195)\n  (:start . 185) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 210)\n  (:start . 199) (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 219)\n  (:start . 211) (:id . 70))\n ((:tag . "JJ") (:stem . "b-regulated") (:form . "B-regulated") (:end . 231)\n  (:start . 220) (:id . 71))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 241)\n  (:start . 232) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s57.5) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000512@unknown@formal@none@1@S@Nonetheless transcription of both the endogenous and the transfected gene was inducible by PMA treatment.@(((:tag . "RB") (:stem . "nonetheless") (:form . "Nonetheless") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s57.6) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000513@unknown@formal@none@1@S@Tax expression in Jurkat T cells may alter the stoichiometry of NF-kappa B DNA binding proteins and thus change the expression of NF-kappa B-regulated promoters.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stoichiometry") (:form . "stoichiometry")\n  (:end . 60) (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "VB") (:stem . "change") (:form . "change") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "JJ") (:stem . "b-regulated") (:form . "B-regulated") (:end . 150)\n  (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 160)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x57.7.1) (:span 33 36)))\n (:hscopes ((:id . :x57.7.1) (:span 33 160)))\n (:identifiers (:sid . :s57.7) (:did . :|91361546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000514@unknown@formal@none@1@S@Regulation of glucocorticoid receptors in human mononuclear cells: effects of glucocorticoid treatment, Cushing 's disease and ketoconazole.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 92) (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ketoconazole") (:form . "ketoconazole") (:end . 139)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s58.1) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000515@unknown@formal@none@1@S@Glucocorticoid receptors (GcR) were determined by a whole cell assay in human mononulear leukocytes (hMNL) from control subjects, patients receiving glucocorticoid therapy for systemic diseases and Cushing 's disease patients with or without ketoconazole therapy.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GcR") (:form . "GcR") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononulear") (:form . "mononulear") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hmnl") (:form . "hMNL") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "control") (:form . "control") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "VBG") (:stem . "receive") (:form . "receiving") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 163) (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 205)\n  (:start . 198) (:id . 73))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 225)\n  (:start . 217) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 230) (:start . 226)\n  (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 241)\n  (:start . 234) (:id . 79))\n ((:tag . "NN") (:stem . "ketoconazole") (:form . "ketoconazole") (:end . 254)\n  (:start . 242) (:id . 80))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 262)\n  (:start . 255) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x58.2.1) (:span 234 241)))\n (:nscopes ((:id . :x58.2.1) (:span 234 262)))\n (:identifiers (:sid . :s58.2) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000516@unknown@formal@none@1@S@Prolonged corticosteroid treatment resulted in down-regulation of GcR, while the mean level of GcR in Cushing 's disease was normal.@(((:tag . "VBN") (:stem . "prolong") (:form . "Prolonged") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 34)\n  (:start . 25) (:id . 44))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 43)\n  (:start . 35) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 62) (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GcR") (:form . "GcR") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GcR") (:form . "GcR") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s58.3) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000517@unknown@formal@none@1@S@In this group, however, receptor levels and morning plasma cortisol values showed a negative correlation, indicating a subtle down-regulatory effect.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "morning") (:form . "morning") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 81) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 104)\n  (:start . 93) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "subtle") (:form . "subtle") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "down-regulatory") (:form . "down-regulatory")\n  (:end . 141) (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x58.4.1) (:span 106 116)))\n (:hscopes ((:id . :x58.4.1) (:span 106 148)))\n (:identifiers (:sid . :s58.4) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000518@unknown@formal@none@1@S@Furthermore, GcR were unaltered after these patients received ketoconazole, in spite of a marked reduction in morning plasma cortisol and urinary free cortisol.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GcR") (:form . "GcR") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "VBD") (:stem . "receive") (:form . "received") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "ketoconazole") (:form . "ketoconazole") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "spite") (:form . "spite") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "morning") (:form . "morning") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "urinary") (:form . "urinary") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s58.5) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000520@unknown@formal@none@1@S@The results suggested that GcR in hMNL are down-regulated by synthetic steroids given in vivo, but they showed very mild down-regulation in hypercortisolemic patients suffering from Cushing 's disease.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gcr") (:form . "GcR") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hmnl") (:form . "hMNL") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 57) (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "steroid") (:form . "steroids") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "mild") (:form . "mild") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 136) (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "hypercortisolemic") (:form . "hypercortisolemic")\n  (:end . 157) (:start . 140) (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "VBG") (:stem . "suffer") (:form . "suffering") (:end . 176)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 189)\n  (:start . 182) (:id . 69))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x58.7.1) (:span 12 21)))\n (:hscopes ((:id . :x58.7.1) (:span 12 93)))\n (:identifiers (:sid . :s58.7) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000521@unknown@formal@none@1@S@Finally, we did not observed either up-regulation or antagonism of GcR by ketoconazole treatment, at the time that cortisol levels of patients with Cushing 's disease were reduced.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "antagonism") (:form . "antagonism") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gcr") (:form . "GcR") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ketoconazole") (:form . "ketoconazole") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 142)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 179)\n  (:start . 172) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x58.8.1) (:span 16 19)))\n (:nscopes ((:id . :x58.8.1) (:span 16 179)))\n (:identifiers (:sid . :s58.8) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000522@unknown@formal@none@1@S@This indicates that the beneficial effects of ketoconazole in Cushing 's disease are due to adrenal cortisol suppression and not to interaction with GcR of target cells, and that the process of GcR regulation in hMNL is a complex phenomenon awaiting further elucidation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ketoconazole") (:form . "ketoconazole") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Cushing") (:form . "Cushing") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gcr") (:form . "GcR") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 162)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 178) (:start . 174)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 190)\n  (:start . 183) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GcR") (:form . "GcR") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 208)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 77))\n ((:tag . "NN") (:stem . "hmnl") (:form . "hMNL") (:end . 216) (:start . 212)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 219) (:start . 217)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 221) (:start . 220)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 229)\n  (:start . 222) (:id . 81))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 240)\n  (:start . 230) (:id . 82))\n ((:tag . "VBG") (:stem . "await") (:form . "awaiting") (:end . 249)\n  (:start . 241) (:id . 83))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 257)\n  (:start . 250) (:id . 84))\n ((:tag . "NN") (:stem . "elucidation") (:form . "elucidation") (:end . 269)\n  (:start . 258) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x58.9.2) (:span 5 19)))\n (:ncues ((:id . :x58.9.1) (:span 125 128)))\n (:hscopes ((:id . :x58.9.2) (:span 5 269)))\n (:nscopes ((:id . :x58.9.1) (:span 125 168)))\n (:identifiers (:sid . :s58.9) (:did . :|91363265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000523@unknown@formal@none@1@S@Glucocorticoid receptors in lymphocytes in anorexia nervosa.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "anorexia") (:form . "anorexia") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "nervosa") (:form . "nervosa") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s59.1) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000524@unknown@formal@none@1@S@OBJECTIVE : The aim was to explore the down-regulation of the glucocorticoid receptors during hypercortisolaemia in anorexia nervosa.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 54) (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 76) (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "hypercortisolaemia") (:form . "hypercortisolaemia")\n  (:end . 112) (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "anorexia") (:form . "anorexia") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "nervosa") (:form . "nervosa") (:end . 132)\n  (:start . 125) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s59.2) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000525@unknown@formal@none@1@S@DESIGN : Urine and plasma samples were obtained for cortisol determination and blood lymphocytes were isolated for receptor binding studies.@(((:tag . "NN") (:stem . "design") (:form . "DESIGN") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "urine") (:form . "Urine") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 74) (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s59.3) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000526@unknown@formal@none@1@S@PATIENTS : Sixteen anorexic patients, aged 16-27 years, with a mean ± SEM body mass index of 14.2 ± 2.0 (ranging from 11.1 to 17.4), and 15 normal women were studied.@(((:tag . "NNS") (:stem . "patients") (:form . "PATIENTS") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "sixteen") (:form . "Sixteen") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "anorexic") (:form . "anorexic") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "age") (:form . "aged") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "CD") (:stem . "16-27") (:form . "16-27") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "index") (:form . "index") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "CD") (:stem . "14.2") (:form . "14.2") (:end . 97) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 99) (:start . 98)\n  (:id . 62))\n ((:tag . "CD") (:stem . "2.0") (:form . "2.0") (:end . 103) (:start . 100)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 112)\n  (:start . 105) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 66))\n ((:tag . "CD") (:stem . "11.1") (:form . "11.1") (:end . 122) (:start . 118)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 68))\n ((:tag . "CD") (:stem . "17.4") (:form . "17.4") (:end . 130) (:start . 126)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 72))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 139) (:start . 137)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 146)\n  (:start . 140) (:id . 74))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 152)\n  (:start . 147) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 157) (:start . 153)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 165)\n  (:start . 158) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s59.4) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000527@unknown@formal@none@1@S@Six patients were reinvestigated after a significant weight gain.@(((:tag . "CD") (:stem . "six") (:form . "Six") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "reinvestigate") (:form . "reinvestigated")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "gain") (:form . "gain") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s59.5) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000528@unknown@formal@none@1@S@MEASUREMENTS : The binding capacity and affinity of the glucocorticoid receptors were measured with dexamethasone as ligand on lymphocytes.@(((:tag . "NNS") (:stem . "measurements") (:form . "MEASUREMENTS") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 70) (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 113) (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s59.6) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000530@unknown@formal@none@1@S@the number of glucocorticoid receptors per cell (Ro) and the binding affinity (Kd) for dexamethasone were , however, not significantly different (Ro: 7687 ± 1750 vs 7347 ± 1285 sites/cell; Kd: 7.7 ± 2.4 vs 7.4 ± 1.7 nM at 24 degrees C).@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . 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5000531@unknown@formal@none@1@S@After weight gain (14 ± 2 to 16 ± 2 kg/m2), receptor numbers were 8421 ± 2126 (pre) and 9011 ± 500 (post) sites/cell, which are not significantly different (P greater than 0.2);@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gain") (:form . "gain") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 49))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 31) (:start . 29)\n  (:id . 50))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 33) (:start . 32)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 35) (:start . 34)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kg/m2") (:form . "kg/m2") (:end . 41) (:start . 36)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 56))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 60)\n  (:start . 53) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 65) (:start . 61)\n  (:id . 58))\n ((:tag . "CD") (:stem . "8421") (:form . "8421") (:end . 70) (:start . 66)\n  (:id . 59))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 72) (:start . 71)\n  (:id . 60))\n ((:tag . "CD") (:stem . "2126") (:form . "2126") (:end . 77) (:start . 73)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pre") (:form . "pre") (:end . 82) (:start . 79)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 65))\n ((:tag . "CD") (:stem . "9011") (:form . "9011") (:end . 92) (:start . 88)\n  (:id . 66))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 94) (:start . 93)\n  (:id . 67))\n ((:tag . "CD") (:stem . "500") (:form . "500") (:end . 98) (:start . 95)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 69))\n ((:tag . "NN") (:stem . "post") (:form . "post") (:end . 104) (:start . 100)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "sites/cell") (:form . "sites/cell") (:end . 116)\n  (:start . 106) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 123)\n  (:start . 118) (:id . 74))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 127) (:start . 124)\n  (:id . 75))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 131) (:start . 128)\n  (:id . 76))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 145) (:start . 132) (:id . 77))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 155)\n  (:start . 146) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 79))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 158) (:start . 157)\n  (:id . 80))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 166)\n  (:start . 159) (:id . 81))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 171) (:start . 167)\n  (:id . 82))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 175) (:start . 172)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 84))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 177) (:start . 176)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s59.9) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000532@unknown@formal@none@1@S@the Kd was unchanged (9.3 ± 2.6 vs 9.2 ± 2.4 nM).@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "9.3") (:form . "9.3") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "CD") (:stem . "2.6") (:form . "2.6") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "vs") (:form . "vs") (:end . 34) (:start . 32)\n  (:id . 50))\n ((:tag . "CD") (:stem . "9.2") (:form . "9.2") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 40) (:start . 39)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2.4") (:form . "2.4") (:end . 44) (:start . 41)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 47) (:start . 45)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s59.10) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000533@unknown@formal@none@1@S@CONCLUSIONS Hypercortisolaemia does not down-regulate the lymphocyte glucocorticoid receptors in anorexia nervosa and a post-receptor defect might be involved in peripheral tissue resistance to the effects of glucocorticoid hormones in undernutrition.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Hypercortisolaemia") (:form . "Hypercortisolaemia")\n  (:end . 30) (:start . 12) (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 35) (:start . 31)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 45))\n ((:tag . "VB") (:stem . "down-regulate") (:form . "down-regulate")\n  (:end . 53) (:start . 40) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 68)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 83) (:start . 69) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 93)\n  (:start . 84) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 51))\n ((:tag . "NN") (:stem . "anorexia") (:form . "anorexia") (:end . 105)\n  (:start . 97) (:id . 52))\n ((:tag . "NN") (:stem . "nervosa") (:form . "nervosa") (:end . 113)\n  (:start . 106) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "post-receptor") (:form . "post-receptor")\n  (:end . 133) (:start . 120) (:id . 56))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 140)\n  (:start . 134) (:id . 57))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 146)\n  (:start . 141) (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 158)\n  (:start . 150) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 172)\n  (:start . 162) (:id . 62))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 179)\n  (:start . 173) (:id . 63))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 190)\n  (:start . 180) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 205)\n  (:start . 198) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 68))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 223) (:start . 209) (:id . 69))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 232)\n  (:start . 224) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 71))\n ((:tag . "NN") (:stem . "undernutrition") (:form . "undernutrition")\n  (:end . 250) (:start . 236) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x59.11.1) (:span 141 146)))\n (:ncues ((:id . :x59.11.2) (:span 36 39)))\n (:hscopes ((:id . :x59.11.1) (:span 118 250)))\n (:nscopes ((:id . :x59.11.2) (:span 36 113)))\n (:identifiers (:sid . :s59.11) (:did . :|91364264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000534@unknown@formal@none@1@S@Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 69) (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s60.1) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000535@unknown@formal@none@1@S@Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 23) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s60.2) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000536@unknown@formal@none@1@S@The cytokine TNF mediates many of the pathologic signs of cachexia, inflammation, and sepsis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pathologic") (:form . "pathologic") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "sign") (:form . "signs") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cachexia") (:form . "cachexia") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s60.3) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000537@unknown@formal@none@1@S@The current work describes the regulation of TNF in human myelomonocytic cell lines after PMA stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 72) (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s60.4) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000538@unknown@formal@none@1@S@The cell lines exhibit a low level of constitutive TNF mRNA expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 50)\n  (:start . 38) (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s60.5) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000540@unknown@formal@none@1@S@This rise is due to increased mRNA stability, which increased by almost twofold, and to an overall increase in transcription, which rises by more than sixfold.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "RB") (:stem . "twofold") (:form . "twofold") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "VBZ") (:stem . "rise") (:form . "rises") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 150) (:start . 146)\n  (:id . 69))\n ((:tag . "RB") (:stem . "sixfold") (:form . "sixfold") (:end . 158)\n  (:start . 151) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s60.7) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000541@unknown@formal@none@1@S@At the level of the genomic TNF gene, a DNase I hypersensitive site is detected within the TNF promoter between -200 to -100 bp relative to the transcription initiation site.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 45) (:start . 40)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 47) (:start . 46)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 62) (:start . 48) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 79)\n  (:start . 71) (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "CD") (:stem . "-200") (:form . "-200") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-100") (:form . "-100") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 136)\n  (:start . 128) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 70))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 168)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s60.8) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000542@unknown@formal@none@1@S@Although absent in nonexpressing erythroleukemia cell lines, the DNase I site is present in uninduced myelomonocytic cell lines and is not changed after PMA induction.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "nonexpresse") (:form . "nonexpressing") (:end . 32)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 48) (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 59) (:start . 54)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 116) (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "change") (:form . "changed") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 166)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x60.9.1) (:span 135 138)))\n (:nscopes ((:id . :x60.9.1) (:span 132 166)))\n (:identifiers (:sid . :s60.9) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000543@unknown@formal@none@1@S@The PMA induction of c-fos mRNA correlated well with TNF gene induction;@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s60.10) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000544@unknown@formal@none@1@S@expression of genes encoding other proteins in the AP-1 complex (junB and junD) were also induced by PMA.@(((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "jund") (:form . "junD") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s60.11) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000545@unknown@formal@none@1@S@The nuclear extracts from resting and induced ML-1 cells contain proteins binding specifically to the AP-1, AP-2, and NF kappa B sequence located within the TNF promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "ml-1") (:form . "ML-1") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 94)\n  (:start . 82) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 152)\n  (:start . 146) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 169)\n  (:start . 161) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s60.12) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000546@unknown@formal@none@1@S@PMA induction increases the level of a number of specific binding complexes relative to the resting cells.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s60.13) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000547@unknown@formal@none@1@S@The regulatory mechanisms of the human and murine TNF genes are discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s60.14) (:did . :|91366165|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000548@unknown@formal@none@1@S@USF-related transcription factor, HIV-TF1, stimulates transcription of human immunodeficiency virus-1.@(((:tag . "JJ") (:stem . "usf-related") (:form . "USF-related") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-TF1") (:form . "HIV-TF1") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 93) (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "virus-1") (:form . "virus-1") (:end . 101)\n  (:start . 94) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s61.1) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000550@unknown@formal@none@1@S@HIV-TF1 had a molecular weight of 39,000.@(((:tag . "NNP") (:stem . "HIV-TF1") (:form . "HIV-TF1") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "39,000") (:form . "39,000") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 41) (:start . 40)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s61.3) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000551@unknown@formal@none@1@S@Binding of HIV-TF1 to the HIV long terminal repeat (LTR) activated transcription from the HIV promoter in vitro.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hiv-tf1") (:form . "HIV-TF1") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 66)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s61.4) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000552@unknown@formal@none@1@S@The HIV-TF1-binding site in HIV LTR was similar to the site recognized by upstream stimulatory factor (USF) in the adenovirus major late promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hiv-tf1-binding") (:form . "HIV-TF1-binding")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "USF") (:form . "USF") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s61.5) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000553@unknown@formal@none@1@S@DNA-binding properties of HIV-TF1 suggested that HIV-TF1 might be identical or related to USF.@(((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-TF1") (:form . "HIV-TF1") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hiv-tf1") (:form . "HIV-TF1") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "USF") (:form . "USF") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x61.6.1) (:span 76 78)) ((:id . :x61.6.2) (:span 57 62))\n  ((:id . :x61.6.3) (:span 34 43)))\n (:hscopes ((:id . :x61.6.1) (:span 66 86)) ((:id . :x61.6.2) (:span 57 93))\n  ((:id . :x61.6.3) (:span 34 93)))\n (:identifiers (:sid . :s61.6) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000554@unknown@formal@none@1@S@Interestingly, treatment of purified HIV-TF1 by phosphatase greatly reduced its DNA-binding activity, suggesting that phosphorylation of HIV-TF1 was essential for DNA binding.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "hiv-tf1") (:form . "HIV-TF1") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 91)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 133) (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-TF1") (:form . "HIV-TF1") (:end . 144)\n  (:start . 137) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 158)\n  (:start . 149) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 174)\n  (:start . 167) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x61.7.1) (:span 102 112)))\n (:hscopes ((:id . :x61.7.1) (:span 102 174)))\n (:identifiers (:sid . :s61.7) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000555@unknown@formal@none@1@S@The disruption of HIV-TF1-binding site induced a 60 % decrease in the level of transcription from the HIV promoter in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hiv-tf1-binding") (:form . "HIV-TF1-binding")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s61.8) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000556@unknown@formal@none@1@S@These results suggest that HIV-TF1 is involved in transcriptional regulation of HIV-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hiv-tf1") (:form . "HIV-TF1") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 65) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x61.9.1) (:span 14 21)))\n (:hscopes ((:id . :x61.9.1) (:span 14 85)))\n (:identifiers (:sid . :s61.9) (:did . :|91367666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000557@unknown@formal@none@1@S@The effect of toremifene therapy on serum immunoglobulin levels in breast cancer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "toremifene") (:form . "toremifene") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 56) (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s62.1) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000558@unknown@formal@none@1@S@Estrogens and anti-estrogens enhance the number of immunoglobulin ( Ig ) -secreting cells in pokeweed mitogen ( PWM ) -stimulated lymphocyte cultures.@(((:tag . "NNP") (:stem . "Estrogen") (:form . "Estrogens") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "anti-estrogen") (:form . "anti-estrogens")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "-secreting") (:form . "-secreting") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pokeweed") (:form . "pokeweed") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "-stimulated") (:form . "-stimulated") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s62.2) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000560@unknown@formal@none@1@S@In this study the effect of anti-estrogen ( toremifene ) therapy on serum immunoglobulin (IgA, IgM, IgG) levels in breast cancer patients was investigated.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "anti-estrogen") (:form . "anti-estrogen")\n  (:end . 41) (:start . 28) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "toremifene") (:form . "toremifene") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 88) (:start . 74) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IgA") (:form . "IgA") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IgM") (:form . "IgM") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 111)\n  (:start . 105) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 121)\n  (:start . 115) (:id . 65))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 128)\n  (:start . 122) (:id . 66))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 154)\n  (:start . 142) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s62.4) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000561@unknown@formal@none@1@S@Serum Ig levels were followed up to two years after or during the therapy.@(((:tag . "NNP") (:stem . "Serum") (:form . "Serum") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s62.5) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000562@unknown@formal@none@1@S@An unexpected finding was that the Ig levels decreased during the follow-up period.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unexpected") (:form . "unexpected") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "follow-up") (:form . "follow-up") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s62.6) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000563@unknown@formal@none@1@S@This decrease was seen in patients who responded to the therapy as well as in those who did not.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x62.7.1) (:span 92 95)))\n (:nscopes ((:id . :x62.7.1) (:span 92 95)))\n (:identifiers (:sid . :s62.7) (:did . :|91369589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000564@unknown@formal@none@1@S@HIV1 infection of human monocytes and macrophages promotes induction or translocation of NF-KB-related factors.@(((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nf-kb-related") (:form . "NF-KB-related")\n  (:end . 102) (:start . 89) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s63.1) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000565@unknown@formal@none@1@S@In 1991, we demonstrated , using electrophoretic mobility shift assays, that 3 different factors (termed B1, B2 and B3) with affinity for the KB-enhancer target sequence were specifically detected in nuclear extracts from HIV1-infected monocytes and macrophages.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 24)\n  (:start . 12) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 48) (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "b3") (:form . "B3") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 133)\n  (:start . 125) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "KB-enhancer") (:form . "KB-enhancer") (:end . 153)\n  (:start . 142) (:id . 70))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 169)\n  (:start . 161) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 187)\n  (:start . 175) (:id . 74))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 196)\n  (:start . 188) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 207)\n  (:start . 200) (:id . 77))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 216)\n  (:start . 208) (:id . 78))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 221) (:start . 217)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "hiv1-infected") (:form . "HIV1-infected")\n  (:end . 235) (:start . 222) (:id . 80))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 245)\n  (:start . 236) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 249) (:start . 246)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 261)\n  (:start . 250) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s63.2) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000566@unknown@formal@none@1@S@The B2 factor was induced in the nuclei of these cells only upon HIV1 infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s63.3) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000567@unknown@formal@none@1@S@The B3 factor was only slightly evident in nuclei of uninfected cells but was readily detectable in nuclei of infected monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "b3") (:form . "B3") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s63.4) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000568@unknown@formal@none@1@S@Its expression remained very low in nuclei of HIV1-infected macrophages.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hiv1-infected") (:form . "HIV1-infected")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s63.5) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000570@unknown@formal@none@1@S@This factor remained clustered in the cytosol and was translocated to the nuclei only after HIV1 infection.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBN") (:stem . "cluster") (:form . "clustered") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s63.7) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000571@unknown@formal@none@1@S@The B3 factor is detected in the cytosol only when cells are HIV1-infected.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "b3") (:form . "B3") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hiv1-infected") (:form . "HIV1-infected")\n  (:end . 74) (:start . 61) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s63.8) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000572@unknown@formal@none@1@S@The role of HIV1 infection in the expression and the translocation of these factors is discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s63.9) (:did . :|91376383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000573@unknown@formal@none@1@S@Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 55) (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hiv-gene") (:form . "HIV-gene") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s64.1) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000574@unknown@formal@none@1@S@Cells of the monocyte-macrophage lineage are important targets of HIV infection.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophage") (:end . 32) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s64.2) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000575@unknown@formal@none@1@S@We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor alpha (TNF alpha) is associated with expression of nuclear factor kappa B (NF-kappa B).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 50) (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 157)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 184)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 191)\n  (:start . 185) (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 209)\n  (:start . 201) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 211) (:start . 210)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s64.3) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000576@unknown@formal@none@1@S@In parallel with such differentiation, HIV transcription, monitored using an HIV long terminal repeat reporter gene construct, is activated in such cells under the influence of enhanced NF-kappa B expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "monitor") (:form . "monitored") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 173)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 185)\n  (:start . 177) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 207)\n  (:start . 197) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s64.4) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000577@unknown@formal@none@1@S@Also, in a promonocyte cell line chronically infected with HIV, NF-kappa B expression and HIV transcription were enhanced on stimulation with phorbol ester or TNF alpha.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promonocyte") (:form . "promonocyte") (:end . 22)\n  (:start . 11) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s64.5) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000578@unknown@formal@none@1@S@Thus, stimulation of monocyte cell lines by phorbol esters or TNF alpha induces cell differentiation and activates HIV transcription.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 100) (:start . 85) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s64.6) (:did . :|91376384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000580@unknown@formal@none@1@S@A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 158)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 169)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 185)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 190) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 197)\n  (:start . 191) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 218)\n  (:start . 208) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 221) (:start . 219)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 230)\n  (:start . 222) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 232) (:start . 231)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s65.1) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000581@unknown@formal@none@1@S@Activation of T cells by antigen, lectin, or a combination of phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) leads to the induction of genes for a set of lymphokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF).@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 58)\n  (:start . 47) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phorbol-12-myristate")\n  (:form . "phorbol-12-myristate") (:end . 82) (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "a23187") (:form . "A23187") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 133)\n  (:start . 128) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 150)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 159)\n  (:start . 154) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 73))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 169) (:start . 166)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "lymphokine") (:form . "lymphokines") (:end . 184)\n  (:start . 173) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 195)\n  (:start . 186) (:id . 78))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 218) (:start . 196) (:id . 79))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 237) (:start . 219) (:id . 80))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 244)\n  (:start . 238) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 246) (:start . 245)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 252)\n  (:start . 246) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 253) (:start . 252)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s65.2) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000582@unknown@formal@none@1@S@We demonstrated in earlier studies that the upstream region of the mouse GM-CSF promoter at positions between -95 and -73 is essential for transcriptional activation in response to PMA/A23187.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "CD") (:stem . "-95") (:form . "-95") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-73") (:form . "-73") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 154) (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pma/a23187") (:form . "PMA/A23187") (:end . 191)\n  (:start . 181) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s65.3) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000583@unknown@formal@none@1@S@This region contains two DNA-binding motifs, GM2 and GC-box.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GM2") (:form . "GM2") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GC-box") (:form . "GC-box") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s65.4) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000584@unknown@formal@none@1@S@The GM2 sequence (GGTAGTTCCC) is recognized by an inducible factor NF-GM2; the other (CCGCCC) by constitutive factors A1, A2, and B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gm2") (:form . "GM2") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GGTAGTTCCC") (:form . "GGTAGTTCCC") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CCGCCC") (:form . "CCGCCC") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 109)\n  (:start . 97) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 117)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "a1") (:form . "A1") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "A2") (:form . "A2") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 131) (:start . 130)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s65.5) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000585@unknown@formal@none@1@S@To elucidate the mechanism of GM-CSF gene activation, we have purified the inducible factor NF-GM2 from the nuclear extract of stimulated Jurkat cells on the basis of specific DNA-binding activity.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 144)\n  (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 175)\n  (:start . 167) (:id . 70))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 187)\n  (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 196)\n  (:start . 188) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s65.6) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000586@unknown@formal@none@1@S@The purified NF-GM2 consists of 50 (p50) and 65 kDa (p65) polypeptides and has a binding activity specific for both the GM-CSF and immunoglobulin kappa (GGAAAGTCCC) enhancers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 56) (:start . 53)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 70)\n  (:start . 58) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 88)\n  (:start . 81) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 106)\n  (:start . 98) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 126)\n  (:start . 120) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 68))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 145) (:start . 131) (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "GGAAAGTCCC") (:form . "GGAAAGTCCC") (:end . 163)\n  (:start . 153) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 174)\n  (:start . 165) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s65.7) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000587@unknown@formal@none@1@S@Electrophoretically purified p50 alone can form a protein-DNA complex, but in the mixture, p50 associates preferentially with p65 to form the NF-GM2 complex.@(((:tag . "RB") (:stem . "electrophoretically")\n  (:form . "Electrophoretically") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 28)\n  (:start . 20) (:id . 43))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 32) (:start . 29)\n  (:id . 44))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 38) (:start . 33)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mixture") (:form . "mixture") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 120) (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 148)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 156)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s65.8) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000588@unknown@formal@none@1@S@In addition, p65 gave per se, with low affinity, a protein-DNA complex that migrated more slowly than native NF-GM2 complex.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "give") (:form . "gave") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "FW") (:stem . "per") (:form . "per") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "FW") (:stem . "se") (:form . "se") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 47)\n  (:start . 39) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 62)\n  (:start . 51) (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 70)\n  (:start . 63) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "migrate") (:form . "migrated") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "RB") (:stem . "slowly") (:form . "slowly") (:end . 96)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s65.9) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000590@unknown@formal@none@1@S@The purified NF-GM2 activated in vitro transcription from the kappa B enhancer, while it failed to stimulate transcription from the GM-CSF promoter harboring the GM2 sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 95) (:start . 89)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "VBG") (:stem . "harbor") (:form . "harboring") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gm2") (:form . "GM2") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x65.11.1) (:span 89 95)))\n (:nscopes ((:id . :x65.11.1) (:span 89 174)))\n (:identifiers (:sid . :s65.11) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000591@unknown@formal@none@1@S@This suggests that the activation mechanism of the GM-CSF gene through the GM2/GC-box sequence is different from that of genes carrying the kappa B enhancer alone.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gm2/gc-box") (:form . "GM2/GC-box") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x65.12.1) (:span 5 13)))\n (:hscopes ((:id . :x65.12.1) (:span 5 162)))\n (:identifiers (:sid . :s65.12) (:did . :|92001749|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000592@unknown@formal@none@1@S@Glucocorticoid receptors in normal leukocytes: effects of age, gender, season, and plasma cortisol concentrations.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gender") (:form . "gender") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "season") (:form . "season") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 113) (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s66.1) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000593@unknown@formal@none@1@S@We measured glucocorticoid receptors (GR) in mononuclear leukocytes (MNL) isolated from peripheral blood of 145 apparently healthy volunteers (86 men and 59 women).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "CD") (:stem . "145") (:form . "145") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "CD") (:stem . "86") (:form . "86") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "man") (:form . "men") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "CD") (:stem . "59") (:form . "59") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s66.2) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000594@unknown@formal@none@1@S@An age-related decrease in the number of GR was suggested between subjects younger than 20 years and elderly subjects;@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "JJR") (:stem . "young") (:form . "younger") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x66.3.1) (:span 48 57)))\n (:hscopes ((:id . :x66.3.1) (:span 0 117)))\n (:identifiers (:sid . :s66.3) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000595@unknown@formal@none@1@S@there was no apparent seasonal variation in GR.@(((:tag . "EX") (:stem . "there") (:form . "there") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "seasonal") (:form . "seasonal") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x66.4.1) (:span 10 12)))\n (:nscopes ((:id . :x66.4.1) (:span 10 46)))\n (:identifiers (:sid . :s66.4) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000596@unknown@formal@none@1@S@Gender difference in the number of GR was not significant, although women showed slightly fewer GR.@(((:tag . "NN") (:stem . "gender") (:form . "Gender") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 80) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s66.5) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000597@unknown@formal@none@1@S@Eight patients with dermatomyositis/polymyositis were examined to determine whether the number of GR in MNL could be down-regulated by their cognate ligands.@(((:tag . "CD") (:stem . "eight") (:form . "Eight") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dermatomyositis/polymyositis")\n  (:form . "dermatomyositis/polymyositis") (:end . 48) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 62)\n  (:start . 54) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 75)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 83)\n  (:start . 76) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 94)\n  (:start . 88) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 131) (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 156)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x66.6.1) (:span 108 113)) ((:id . :x66.6.2) (:span 76 83)))\n (:hscopes ((:id . :x66.6.1) (:span 84 156))\n  ((:id . :x66.6.2) (:span 76 156)))\n (:identifiers (:sid . :s66.6) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000598@unknown@formal@none@1@S@The number of GR in MNL from these patients was significantly decreased one month after the initiation of prednisolone therapy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 61) (:start . 48) (:id . 52))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "month") (:form . "month") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "prednisolone") (:form . "prednisolone") (:end . 118)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s66.7) (:did . :|92006162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000600@unknown@formal@none@1@S@Anti-CD2 receptor antibodies activate the HIV long terminal repeat in T lymphocytes.@(((:tag . "NN") (:stem . "anti-cd2") (:form . "Anti-CD2") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s67.1) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000601@unknown@formal@none@1@S@The CD2 T lymphocyte glycoprotein surface molecule mediates both cell to cell adhesion and T cell activation, two processes that are involved in the spread of HIV infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "spread") (:form . "spread") (:end . 155)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 172)\n  (:start . 163) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s67.2) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000602@unknown@formal@none@1@S@Treatment of chronically HIV-infected PBMC with anti-CD2 mAb has been shown to induce the expression of infectious virus from these cultures.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s67.3) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000603@unknown@formal@none@1@S@In this study we investigated the mechanisms whereby anti-CD2 antibodies stimulate viral production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s67.4) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000604@unknown@formal@none@1@S@We demonstrate that treatment of transiently transfected T lymphocytes with anti-CD2 antibodies results in activation of the HIV long terminal repeat.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 70)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 103)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 149)\n  (:start . 143) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s67.5) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000605@unknown@formal@none@1@S@Furthermore, CAT assays using mutated HIV long terminal repeat-CAT constructs and gel shift assays demonstrate that this activation is dependent on the NF-kappa B enhancer.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "repeat-cat") (:form . "repeat-CAT") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s67.6) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000606@unknown@formal@none@1@S@These studies suggest that interaction of CD2 with its natural ligand, LFA-3, may play a role in regulation of HIV expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LFA-3") (:form . "LFA-3") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x67.7.1) (:span 78 81)) ((:id . :x67.7.2) (:span 14 21)))\n (:hscopes ((:id . :x67.7.1) (:span 78 125))\n  ((:id . :x67.7.2) (:span 14 125)))\n (:identifiers (:sid . :s67.7) (:did . :|92013023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000607@unknown@formal@none@1@S@Nuclear transcription factors that bind to elements of the IL-2 promoter.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s68.1) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000608@unknown@formal@none@1@S@Induction requirements in primary human T cells.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s68.2) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000610@unknown@formal@none@1@S@The sites and their corresponding nuclear binding factors include : NF-kappa B, AP-1, AP-3, OCT-1, and NF-AT.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 19)\n  (:start . 14) (:id . 45))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 33)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AP-3") (:form . "AP-3") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "OCT-1") (:form . "OCT-1") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 108)\n  (:start . 103) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s68.4) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000611@unknown@formal@none@1@S@The latter "nuclear factor for activated T cells" likely contributes to the tissue specificity of IL-2 gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "\\"nuclear") (:form . "\\"nuclear") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x68.5.1) (:span 50 56)))\n (:hscopes ((:id . :x68.5.1) (:span 50 118)))\n (:identifiers (:sid . :s68.5) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000612@unknown@formal@none@1@S@Using electrophoretic mobility shift assays, we have studied these transcription factors in primary T cells from human blood to verify their presence in a physiologic setting and to identify the signals that stimulate factor activity.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "VB") (:stem . "verify") (:form . "verify") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 166)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "setting") (:form . "setting") (:end . 174)\n  (:start . 167) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 190)\n  (:start . 182) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 217)\n  (:start . 208) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 224)\n  (:start . 218) (:id . 76))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 233)\n  (:start . 225) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s68.6) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000613@unknown@formal@none@1@S@All factors are induced in the nuclei of T cells upon activation with mitogens but not with exogenous IL-2 growth factor.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 120)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x68.7.1) (:span 83 86)))\n (:nscopes ((:id . :x68.7.1) (:span 83 120)))\n (:identifiers (:sid . :s68.7) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000614@unknown@formal@none@1@S@However, the signaling requirements and sensitivity to protein synthesis inhibitors differ considerably.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "RB") (:stem . "considerably") (:form . "considerably") (:end . 103)\n  (:start . 91) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s68.8) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000615@unknown@formal@none@1@S@Only the activities for NF-AT and AP-1 sites require two signals for optimal induction, i.e., PMA plus either lectin or antibody to the CD3 or CD28 surface molecules.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 155)\n  (:start . 148) (:id . 70))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 165)\n  (:start . 156) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x68.9.1) (:span 103 109 117 119)))\n (:hscopes ((:id . :x68.9.1) (:span 103 165)))\n (:identifiers (:sid . :s68.9) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000616@unknown@formal@none@1@S@Other factors are induced by lectin, antibody, and/or PMA alone.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s68.10) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000617@unknown@formal@none@1@S@After appropriate stimulation, both NF-AT and AP-1 are peculiarly sensitive to the protein synthesis inhibitor anisomycin.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "peculiarly") (:form . "peculiarly") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "anisomycin") (:form . "anisomycin") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s68.11) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000618@unknown@formal@none@1@S@Our data correlate the activity of NF-AT and AP-1 in gel shift assays with the two signals requirements for IL-2 gene expression.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 103)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s68.12) (:did . :|92013087|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000620@unknown@formal@none@1@S@The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s69.2) (:did . :|92020218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000621@unknown@formal@none@1@S@We have cloned the mouse and human GATA-1 genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s69.3) (:did . :|92020218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000622@unknown@formal@none@1@S@A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 47)\n  (:start . 41) (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "man") (:form . "man") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 101)\n  (:start . 92) (:id . 61))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 110)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 132)\n  (:start . 123) (:id . 65))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 139)\n  (:start . 133) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 164)\n  (:start . 158) (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 167) (:start . 165)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 75))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 179) (:start . 175)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 188)\n  (:start . 180) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s69.4) (:did . :|92020218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000623@unknown@formal@none@1@S@The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "integrity") (:form . "integrity") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dimeric") (:form . "dimeric") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s69.5) (:did . :|92020218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000624@unknown@formal@none@1@S@Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: immunologic crossreactivity and inverse regulation with the vitamin D receptor.@(((:tag . "NN") (:stem . "demonstration") (:form . "Demonstration")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 40) (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "d3-responsive") (:form . "D3-responsive")\n  (:end . 54) (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 83)\n  (:start . 72) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 84) (:start . 83)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 96)\n  (:start . 85) (:id . 52))\n ((:tag . "NN") (:stem . "crossreactivity") (:form . "crossreactivity")\n  (:end . 112) (:start . 97) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 124)\n  (:start . 117) (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 135)\n  (:start . 125) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 152)\n  (:start . 145) (:id . 59))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 154) (:start . 153)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 163)\n  (:start . 155) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s70.1) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000625@unknown@formal@none@1@S@Using Western blot analysis with a monoclonal antibody recognizing a 17-amino acid epitope of the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]receptor, we have detected two crossreacting proteins in activated normal human lymphocytes.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "VBG") (:stem . "recognize") (:form . "recognizing") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "17-amino") (:form . "17-amino") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 119) (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3]receptor")\n  (:form . "1,25(OH)2D3]receptor") (:end . 144) (:start . 124) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "crossreacte") (:form . "crossreacting")\n  (:end . 180) (:start . 167) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 189)\n  (:start . 181) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 202)\n  (:start . 193) (:id . 69))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 209)\n  (:start . 203) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 215)\n  (:start . 210) (:id . 71))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 227)\n  (:start . 216) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s70.2) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000626@unknown@formal@none@1@S@The smaller of the two proteins (50 kDa) was indistinguishable from the classical 1,25(OH)2D3 receptor and , similar to the classical 1,25(OH)2D3 receptor, was upregulated in a dose-dependent fashion by 1,25(OH)2D3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 62) (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 133)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 145)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 171)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 191) (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 199)\n  (:start . 192) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 214)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s70.3) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000627@unknown@formal@none@1@S@The larger crossreacting protein exhibited an electrophoretic mobility of 80 kDa, was localized in the cell cytosol, and appeared to be specific for activated lymphocytes since it was not detected in several other human cells including monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "crossreacte") (:form . "crossreacting") (:end . 24)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 61) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 170)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 179) (:start . 177)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 196)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 207)\n  (:start . 200) (:id . 75))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 219)\n  (:start . 214) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 78))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 235)\n  (:start . 226) (:id . 79))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 245)\n  (:start . 236) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x70.4.2) (:span 121 129)))\n (:ncues ((:id . :x70.4.1) (:span 184 187)))\n (:hscopes ((:id . :x70.4.2) (:span 121 170)))\n (:nscopes ((:id . :x70.4.1) (:span 177 245)))\n (:identifiers (:sid . :s70.4) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000628@unknown@formal@none@1@S@More strikingly, the 80-kDa protein was downregulated in a dose-dependent fashion by 1,25(OH)2D3;@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "strikingly") (:form . "strikingly") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "80-kda") (:form . "80-kDa") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 73) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s70.5) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000630@unknown@formal@none@1@S@However, two potent immunosuppressive agents, glucocorticoids and cyclosporin A, also inhibited the 80-kDa protein.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 37) (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 61) (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "80-kda") (:form . "80-kDa") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s70.7) (:did . :|92020850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000631@unknown@formal@none@1@S@T-helper-cell determinants in protein antigens are preferentially located in cysteine-rich antigen segments resistant to proteolytic cleavage by cathepsin B, L, and D.@(((:tag . "NN") (:stem . "t-helper-cell") (:form . "T-helper-cell")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 26)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 65) (:start . 51) (:id . 48))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 90) (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 98)\n  (:start . 91) (:id . 52))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 117)\n  (:start . 108) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 132)\n  (:start . 121) (:id . 56))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 141)\n  (:start . 133) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 154)\n  (:start . 145) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 159) (:start . 158)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s71.1) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000632@unknown@formal@none@1@S@We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in protein antigen (Ag) by analysing the Ag amino acid sequence.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "computer") (:form . "computer") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "predict") (:form . "predicting") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-helper-cell") (:form . "T-helper-cell")\n  (:end . 85) (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "analyse") (:form . "analysing") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 158)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s71.2) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000633@unknown@formal@none@1@S@The algorithm was constructed with the aim of identifying segments in Ag which are resistant to proteolytic degradation by the enzymes cathepsin B, L, and D.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s71.3) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000634@unknown@formal@none@1@S@These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter APC, and resistant segments in Ag may , therefore, be expected to contain more T-cell determinants than susceptible segments.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endocytic") (:form . "endocytic") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enter") (:form . "enter") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 141)\n  (:start . 132) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 165)\n  (:start . 158) (:id . 70))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 170) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 177)\n  (:start . 171) (:id . 72))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 190)\n  (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 195) (:start . 191)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 207)\n  (:start . 196) (:id . 75))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x71.4.1) (:span 126 129)))\n (:hscopes ((:id . :x71.4.1) (:span 101 216)))\n (:identifiers (:sid . :s71.4) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000635@unknown@formal@none@1@S@From information available in the literature on the substrate specificity of the three enzymes, it is clear that a cysteine is not accepted in any of the S2, S1, S1', and S2' subsites of cathepsin B and L, and not in the S1 and S1' subsites of cathepsin D.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . 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"and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "S1") (:form . "S1") (:end . 230) (:start . 228)\n  (:id . 93))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 231) (:start . 230)\n  (:id . 94))\n ((:tag . "NNS") (:stem . "subsite") (:form . "subsites") (:end . 240)\n  (:start . 232) (:id . 95))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 96))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 253)\n  (:start . 244) (:id . 97))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 255) (:start . 254)\n  (:id . 98))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5000636@unknown@formal@none@1@S@Moreover, we have noticed that cysteine-containing T-cell determinants in a number of protein Ag are particularly rich in the amino acids alanine, glycine, lysine, leucine, serine, threonine, and valine.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "notice") (:form . "noticed") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cysteine-containing")\n  (:form . "cysteine-containing") (:end . 50) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 70)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "rich") (:form . "rich") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "alanine") (:form . "alanine") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "glycine") (:form . "glycine") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lysine") (:form . "lysine") (:end . 162)\n  (:start . 156) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "leucine") (:form . "leucine") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 179)\n  (:start . 173) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 73))\n ((:tag . "NN") (:stem . "threonine") (:form . "threonine") (:end . 190)\n  (:start . 181) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 76))\n ((:tag . "NN") (:stem . "valine") (:form . "valine") (:end . 202)\n  (:start . 196) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s71.6) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000637@unknown@formal@none@1@S@By searching protein Ag for clusters of amino acids containing cysteine and two of the other amino acids we were able to predict 17 out of 23 empirically known T-cell determinants in the Ag with a relatively low number of false (positive) predictions.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "search") (:form . "searching") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "RB") (:stem . "empirically") (:form . "empirically") (:end . 153)\n  (:start . 142) (:id . 69))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 159)\n  (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 166)\n  (:start . 160) (:id . 71))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 179)\n  (:start . 167) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 194) (:start . 190)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 207)\n  (:start . 197) (:id . 78))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 211) (:start . 208)\n  (:id . 79))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 218)\n  (:start . 212) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 227)\n  (:start . 222) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 237)\n  (:start . 229) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 238) (:start . 237)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 250)\n  (:start . 239) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s71.7) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000638@unknown@formal@none@1@S@Furthermore, we present a new principle for searching Ag for potential amphipatic alpha-helical protein segments.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "principle") (:form . "principle") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "search") (:form . "searching") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "amphipatic") (:form . "amphipatic") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "alpha-helical") (:form . "alpha-helical")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s71.8) (:did . :|92022337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000640@unknown@formal@none@1@S@A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cpg-rich") (:form . "CpG-rich") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 144) (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x72.1.1) (:span 8 16)))\n (:hscopes ((:id . :x72.1.1) (:span 8 45)))\n (:identifiers (:sid . :s72.1) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000641@unknown@formal@none@1@S@Genes actively involved in the G0/G1 switch (G0S genes) may be differentially expressed during the lectin-induced switch of lymphocytes from the G0 to the G1 phases of the cell cycle.@(((:tag . "NNS") (:stem . "gene") (:form . "Genes") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "G0S") (:form . "G0S") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 77) (:start . 63) (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lectin-induced") (:form . "lectin-induced")\n  (:end . 113) (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 135)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "g0") (:form . "G0") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 182)\n  (:start . 177) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x72.2.1) (:span 56 59)))\n (:hscopes ((:id . :x72.2.1) (:span 0 182)))\n (:identifiers (:sid . :s72.2) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000642@unknown@formal@none@1@S@This paper presents studies of G0S2, a member of a set of putative G0S genes, for which cDNAs were cloned and selected on the basis of differential cDNA hybridization.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "present") (:form . "presents") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "G0S2") (:form . "G0S2") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 66)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "g0s") (:form . "G0S") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 76) (:start . 71)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 93) (:start . 88)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 98) (:start . 94)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 105)\n  (:start . 99) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 118)\n  (:start . 110) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 147)\n  (:start . 135) (:id . 70))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 152) (:start . 148)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 166) (:start . 153) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x72.3.1) (:span 58 66)))\n (:hscopes ((:id . :x72.3.1) (:span 58 76)))\n (:identifiers (:sid . :s72.3) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000643@unknown@formal@none@1@S@G0S2 mRNA increases transiently within 1-2 hr of the addition of lectin or cycloheximide to cultured blood mononuclear cells.@(((:tag . "NNP") (:stem . "G0S2") (:form . "G0S2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "CD") (:stem . "1-2") (:form . "1-2") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s72.4) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000644@unknown@formal@none@1@S@Comparison of a nearly full-length cDNA sequence with the corresponding genomic sequence reveals one small intron and an open reading frame in the second exon.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s72.5) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000645@unknown@formal@none@1@S@The derived 103-amino-acid basic protein has two potential alpha-helical domains separated by a hydrophobic region with the potential to generate turns and assume a beta-sheet conformation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "103-amino-acid") (:form . "103-amino-acid")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "alpha-helical") (:form . "alpha-helical")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hydrophobic") (:form . "hydrophobic") (:end . 107)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 114)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . "NNS") (:stem . "turn") (:form . "turns") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "VB") (:stem . "assume") (:form . "assume") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "NN") (:stem . "beta-sheet") (:form . "beta-sheet") (:end . 175)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 188)\n  (:start . 176) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s72.6) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000646@unknown@formal@none@1@S@Consistent with involvement in the G0/G1 switch, the protein contains potential sites for phosphorylation by protein kinase C and casein kinase II.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 105) (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 123)\n  (:start . 117) (:id . 59))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "casein") (:form . "casein") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s72.7) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000647@unknown@formal@none@1@S@The gene contains a CpG-rich island suggesting expression in the germ line.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cpg-rich") (:form . "CpG-rich") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "germ") (:form . "germ") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x72.8.1) (:span 36 46)))\n (:hscopes ((:id . :x72.8.1) (:span 36 74)))\n (:identifiers (:sid . :s72.8) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000648@unknown@formal@none@1@S@An upstream segment contains tandem dinucleotide repeats (CT)19/(CA)16.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "dinucleotide") (:form . "dinucleotide") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CT)19/(CA)16") (:form . "CT)19/(CA)16") (:end . 70)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s72.9) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000650@unknown@formal@none@1@S@Potential sites for transcription factors AP1, AP2, and AP3 are consistent with rapid transcriptional activation in response to inducing agents.@(((:tag . "JJ") (:stem . "potential") (:form . "Potential") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP2") (:form . "AP2") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AP3") (:form . "AP3") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x72.11.1) (:span 0 9)))\n (:hscopes ((:id . :x72.11.1) (:span 0 59)))\n (:identifiers (:sid . :s72.11) (:did . :|92029620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000651@unknown@formal@none@1@S@Synergism between two distinct elements of the HTLV-I enhancer during activation by the trans-activator of HTLV-I.@(((:tag . "NNP") (:stem . "Synergism") (:form . "Synergism") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 103) (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s73.1) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000652@unknown@formal@none@1@S@We have conducted functional studies of the enhancer elements of human T-cell leukemia virus type I (HTLV-I) using the human T-cell lines Jurkat and MOLT 4, which are negative for HTLV-I, and MT-2 and TL-Mor, which carry the proviral genome of HTLV-I.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 114) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 131)\n  (:start . 125) (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "MOLT") (:form . "MOLT") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 155) (:start . 154)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 162)\n  (:start . 157) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 175)\n  (:start . 167) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 186)\n  (:start . 180) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "MT-2") (:form . "MT-2") (:end . 196) (:start . 192)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "TL-Mor") (:form . "TL-Mor") (:end . 207)\n  (:start . 201) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 81))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 214)\n  (:start . 209) (:id . 82))\n ((:tag . "VBP") (:stem . "carry") (:form . "carry") (:end . 220)\n  (:start . 215) (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 233)\n  (:start . 225) (:id . 85))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 240)\n  (:start . 234) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 250)\n  (:start . 244) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s73.2) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000653@unknown@formal@none@1@S@Two distinct elements have been implicated in function of the HTLV-I enhancer.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s73.3) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000654@unknown@formal@none@1@S@One is the 21-base-pair (bp) core element that is responsible for trans-activation by the HTLV-I trans-activator p40tax and that has the ability to bind to cyclic-AMP responsive element binding factor ( CREB ) -like factor ( s ).@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "21-base-pair") (:form . "21-base-pair") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 41)\n  (:start . 34) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 61)\n  (:start . 50) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 82) (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 112) (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cyclic-amp") (:form . "cyclic-AMP") (:end . 166)\n  (:start . 156) (:id . 69))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 177)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 185)\n  (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 207) (:start . 203)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "-like") (:form . "-like") (:end . 215)\n  (:start . 210) (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 222)\n  (:start . 216) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 224) (:start . 223)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 226) (:start . 225)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s73.4) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000655@unknown@formal@none@1@S@The other is a region interposed between the 21-bp elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 21)\n  (:start . 15) (:id . 46))\n ((:tag . "VBN") (:stem . "interpose") (:form . "interposed") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "21-bp") (:form . "21-bp") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s73.5) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000656@unknown@formal@none@1@S@In this study we demonstrate that a subfragment (C26) in the region between the 21-bp elements is involved in trans-activation by p40tax, possibly through binding to an NF-kappa B-like nuclear factor or factors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subfragment") (:form . "subfragment") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C26") (:form . "C26") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 67)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 75)\n  (:start . 68) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "21-bp") (:form . "21-bp") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 94)\n  (:start . 86) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 106)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 126) (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 168) (:start . 166)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 177)\n  (:start . 169) (:id . 72))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 192)\n  (:start . 185) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 199)\n  (:start . 193) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 202) (:start . 200)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 210)\n  (:start . 203) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x73.6.1) (:span 200 202))\n  ((:id . :x73.6.2) (:span 138 146)))\n (:hscopes ((:id . :x73.6.1) (:span 193 210))\n  ((:id . :x73.6.2) (:span 138 210)))\n (:identifiers (:sid . :s73.6) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000657@unknown@formal@none@1@S@Formation of the protein-DNA complex with the C26 subfragment was positively affected by p40tax.@(((:tag . "NN") (:stem . "formation") (:form . "Formation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C26") (:form . "C26") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subfragment") (:form . "subfragment") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s73.7) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000658@unknown@formal@none@1@S@The C26 element conferred partial responsiveness to p40tax when linked to one copy of the 21-bp element that, by itself, showed little activation in response to p40tax.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C26") (:form . "C26") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 70) (:start . 64)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "copy") (:form . "copy") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "21-bp") (:form . "21-bp") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 134)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s73.8) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000660@unknown@formal@none@1@S@In contrast, the C26 element itself was profoundly activated upon stimulation with 12-O-tetradecanoylphorbol-13-acetate.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C26") (:form . "C26") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "profoundly") (:form . "profoundly") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 119) (:start . 83)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s73.10) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000661@unknown@formal@none@1@S@These findings therefore suggest that the HTLV-I enhancer contains multiple functional elements, including binding sites for at least CREB- and NF-kappa B-like factors, which synergistically cooperate in activation of the HTLV-I enhancer in response to p40tax.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 114)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "creb-") (:form . "CREB-") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 152)\n  (:start . 144) (:id . 63))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 159)\n  (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 167)\n  (:start . 160) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 190) (:start . 175) (:id . 68))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 200)\n  (:start . 191) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 214)\n  (:start . 204) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 228)\n  (:start . 222) (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 237)\n  (:start . 229) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 76))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 249)\n  (:start . 241) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 252) (:start . 250)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p40tax") (:form . "p40tax") (:end . 259)\n  (:start . 253) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x73.11.1) (:span 25 32)))\n (:hscopes ((:id . :x73.11.1) (:span 25 167)))\n (:identifiers (:sid . :s73.11) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000662@unknown@formal@none@1@S@Our results also demonstrate that TPA-dependent activation of the HTLV-I enhancer may be mediated through the C26 element.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tpa-dependent") (:form . "TPA-dependent")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "C26") (:form . "C26") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x73.12.1) (:span 82 85)))\n (:hscopes ((:id . :x73.12.1) (:span 34 121)))\n (:identifiers (:sid . :s73.12) (:did . :|92031293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000663@unknown@formal@none@1@S@v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.@(((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 21) (:start . 7) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VB") (:stem . "extinguish") (:form . "extinguish") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "c-erba") (:form . "c-erbA") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 97) (:start . 82) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "erba") (:form . "erbA") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CAII") (:form . "CAII") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s74.1) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000664@unknown@formal@none@1@S@The v-erbA oncoprotein represents a retrovirus-transduced oncogenic version of the thyroid hormone ( T3/T4 ) receptor c-erbA ( type alpha ).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "retrovirus-transduced")\n  (:form . "retrovirus-transduced") (:end . 57) (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 67)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 75)\n  (:start . 68) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t3/t4") (:form . "T3/T4") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "NNP") (:stem . "c-erbA") (:form . "c-erbA") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s74.2) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000665@unknown@formal@none@1@S@It contributes to virus-induced erythroleukemia by efficiently arresting differentiation of red cell progenitors and by suppressing transcription of erythrocyte-specific genes.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "virus-induced") (:form . "virus-induced")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 47) (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "VBG") (:stem . "arrest") (:form . "arresting") (:end . 72)\n  (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 88) (:start . 73) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 95) (:start . 92)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 112)\n  (:start . 101) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 131)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 145) (:start . 132) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "erythrocyte-specific")\n  (:form . "erythrocyte-specific") (:end . 169) (:start . 149) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 175)\n  (:start . 170) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s74.3) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000666@unknown@formal@none@1@S@Here, we show that v-erbA and c-erbA bind directly to sequences within the promoter of the erythrocyte-specific carbonic anhydrase II (CAII), a gene whose transcription is efficiently suppressed by v-erbA.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-erba") (:form . "c-erbA") (:end . 36)\n  (:start . 30) (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythrocyte-specific")\n  (:form . "erythrocyte-specific") (:end . 111) (:start . 91) (:id . 59))\n ((:tag . "JJ") (:stem . "carbonic") (:form . "carbonic") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "anhydrase") (:form . "anhydrase") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CAII") (:form . "CAII") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 154)\n  (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 183)\n  (:start . 172) (:id . 72))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 194)\n  (:start . 184) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "v-erbA") (:form . "v-erbA") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s74.4) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000667@unknown@formal@none@1@S@This erbA-binding site confers thyroid hormone responsiveness to a heterologous promoter in transient expression experiments and is a target for efficient down-regulation of CAII transcription by the v-erbA oncoprotein.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "erba-binding") (:form . "erbA-binding") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 61) (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 79)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 124)\n  (:start . 113) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 59))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 140)\n  (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 170) (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CAII") (:form . "CAII") (:end . 178) (:start . 174)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 192) (:start . 179) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 195) (:start . 193)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 68))\n ((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 206)\n  (:start . 200) (:id . 69))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 218)\n  (:start . 207) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s74.5) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000668@unknown@formal@none@1@S@In stably transformed erythroblasts coexpressing the v-erbA oncoprotein and the c-erbA/T3 receptor at an approximately equimolar ratio, c-erbA activity is dominant over v-erbA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "VBG") (:stem . "coexpresse") (:form . "coexpressing") (:end . 48)\n  (:start . 36) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 71)\n  (:start . 60) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-erba/t3") (:form . "c-erbA/T3") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 118) (:start . 105) (:id . 56))\n ((:tag . "JJ") (:stem . "equimolar") (:form . "equimolar") (:end . 128)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 134)\n  (:start . 129) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-erba") (:form . "c-erbA") (:end . 142)\n  (:start . 136) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 151)\n  (:start . 143) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 163)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 168) (:start . 164)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "v-erbA") (:form . "v-erbA") (:end . 175)\n  (:start . 169) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s74.6) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000670@unknown@formal@none@1@S@Likewise, T3 activated CAII transcription as well as transient expression of a T3-responsive reporter gene containing the CAII-specific erbA-binding site.@(((:tag . "RB") (:stem . "likewise") (:form . "Likewise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "CAII") (:form . "CAII") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "t3-responsive") (:form . "T3-responsive")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "caii-specific") (:form . "CAII-specific")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "erba-binding") (:form . "erbA-binding") (:end . 148)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 153) (:start . 149)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s74.8) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000671@unknown@formal@none@1@S@The c-erbA-dependent activation of this CAII reporter construct could only be suppressed by very high amounts of v-erbA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "c-erba-dependent") (:form . "c-erbA-dependent")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CAII") (:form . "CAII") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "v-erbA") (:form . "v-erbA") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x74.9.1) (:span 64 69)))\n (:hscopes ((:id . :x74.9.1) (:span 0 119)))\n (:identifiers (:sid . :s74.9) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000672@unknown@formal@none@1@S@Our results suggest that overexpression of v-erbA is required for its function as an oncoprotein.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 39) (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "v-erbA") (:form . "v-erbA") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x74.10.1) (:span 12 19)))\n (:hscopes ((:id . :x74.10.1) (:span 12 96)))\n (:identifiers (:sid . :s74.10) (:did . :|92038993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000673@unknown@formal@none@1@S@Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1).@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "ester-induced") (:form . "ester-induced")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 61) (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 78) (:start . 65) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 92)\n  (:start . 82) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 52))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 113) (:start . 98) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 122)\n  (:start . 117) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 132)\n  (:start . 127) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s75.1) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5000675@unknown@formal@none@1@S@The present work demonstrates that the glucocorticoid dexamethasone inhibits TPA-induced increases in c-jun and c-fos mRNA levels in U-937 leukemia cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 53) (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 67) (:start . 54) (:id . 49))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 88)\n  (:start . 77) (:id . 51))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 98)\n  (:start . 89) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 107)\n  (:start . 102) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 117)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 129)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s75.3) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000676@unknown@formal@none@1@S@These findings were associated with a block in appearance of the monocytic phenotype, including inhibition of TPA-induced increases in lamin A, lamin C, and vimentin transcripts.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lamin") (:form . "lamin") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lamin") (:form . "lamin") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "vimentin") (:form . "vimentin") (:end . 165)\n  (:start . 157) (:id . 69))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 177)\n  (:start . 166) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s75.4) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000677@unknown@formal@none@1@S@Other studies have demonstrated that TPA-induced monocytic differentiation and expression of the c-jun and c-fos genes in myeloid leukemia cells are regulated by protein kinase C (PKC).@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 74) (:start . 59) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 129)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 158)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 176)\n  (:start . 170) (:id . 66))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s75.5) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000678@unknown@formal@none@1@S@The finding that dexamethasone has no effect on TPA-induced activation of PKC suggests that this glucocorticoid inhibits signals downstream or parallel to this enzyme.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 111) (:start . 97) (:id . 57))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "parallel") (:form . "parallel") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 166)\n  (:start . 160) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x75.6.1) (:span 140 142)) ((:id . :x75.6.2) (:span 78 86)))\n (:ncues ((:id . :x75.6.3) (:span 35 37)))\n (:hscopes ((:id . :x75.6.1) (:span 129 151))\n  ((:id . :x75.6.2) (:span 78 166)))\n (:nscopes ((:id . :x75.6.3) (:span 35 77)))\n (:identifiers (:sid . :s75.6) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000680@unknown@formal@none@1@S@To further define the effects of dexamethasone at the molecular level, we prepared a series of deleted c-jun promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "prepare") (:form . "prepared") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 127)\n  (:start . 118) (:id . 62))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 157) (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 175) (:start . 158) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s75.8) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000681@unknown@formal@none@1@S@Increases in CAT activity during transient expression of these constructs in TPA-treated U-937 cells could be assigned to the region (-97 to -20) of the promoter that contains the AP-1 binding site.@(((:tag . "NNS") (:stem . "increase") (:form . "Increases") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tpa-treated") (:form . "TPA-treated") (:end . 88)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "assign") (:form . "assigned") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "CD") (:stem . "-97") (:form . "-97") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-20") (:form . "-20") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 175)\n  (:start . 167) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 184) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 192)\n  (:start . 185) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 197) (:start . 193)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x75.9.1) (:span 101 106)))\n (:hscopes ((:id . :x75.9.1) (:span 0 197)))\n (:identifiers (:sid . :s75.9) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000682@unknown@formal@none@1@S@This induction of CAT activity was sensitive to dexamethasone.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s75.10) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000683@unknown@formal@none@1@S@These findings suggest that dexamethasone down-regulates TPA-induced transcription of the c-jun gene during monocytic differentiation by inhibiting activation of the AP-1 site.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "down-regulate") (:form . "down-regulates")\n  (:end . 56) (:start . 42) (:id . 47))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 68)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 95) (:start . 90)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 107)\n  (:start . 101) (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 117)\n  (:start . 108) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 133) (:start . 118) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 147)\n  (:start . 137) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 170) (:start . 166)\n  (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 175) (:start . 171)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x75.11.1) (:span 15 22)))\n (:hscopes ((:id . :x75.11.1) (:span 15 175)))\n (:identifiers (:sid . :s75.11) (:did . :|92042309|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000684@unknown@formal@none@1@S@Charybdotoxin-sensitive, Ca(2+)-dependent membrane potential changes are not involved in human T or B cell activation and proliferation.@(((:tag . "JJ") (:stem . "charybdotoxin-sensitive")\n  (:form . "Charybdotoxin-sensitive") (:end . 23) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 41) (:start . 25) (:id . 44))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 50)\n  (:start . 42) (:id . 45))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 60)\n  (:start . 51) (:id . 46))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 68)\n  (:start . 61) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 85)\n  (:start . 77) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 135) (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x76.1.1) (:span 73 76)))\n (:nscopes ((:id . :x76.1.1) (:span 73 135)))\n (:identifiers (:sid . :s76.1) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000685@unknown@formal@none@1@S@The involvement of ion channels in B and T lymphocyte activation is supported by many reports of changes in ion fluxes and membrane potential after mitogen binding.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "flux") (:form . "fluxes") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 141)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x76.2.1) (:span 68 77)))\n (:hscopes ((:id . :x76.2.1) (:span 0 163)))\n (:identifiers (:sid . :s76.2) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000686@unknown@formal@none@1@S@Human T and B lymphocytes demonstrate an early and transient hyperpolarization after ligand binding.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 25)\n  (:start . 14) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "hyperpolarization") (:form . "hyperpolarization")\n  (:end . 78) (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s76.3) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000687@unknown@formal@none@1@S@Inasmuch as the change in membrane potential is dependent on elevation of free cytosolic calcium, the hyperpolarization is presumably through opening of Ca(2+)-stimulated K+ channels.@(((:tag . "RB") (:stem . "inasmuch") (:form . "Inasmuch") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hyperpolarization") (:form . "hyperpolarization")\n  (:end . 119) (:start . 102) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "opening") (:form . "opening") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "Ca(2+)-stimulated") (:form . "Ca(2+)-stimulated")\n  (:end . 170) (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 182)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x76.4.1) (:span 123 133)))\n (:hscopes ((:id . :x76.4.1) (:span 123 182)))\n (:identifiers (:sid . :s76.4) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000688@unknown@formal@none@1@S@We have used charybdotoxin, a known inhibitor of Ca(2+)-dependent K+ channels, to study the role of these channels in lymphocyte activation and mitogenesis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "charybdotoxin") (:form . "charybdotoxin")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 65) (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "K+") (:form . "K+") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s76.5) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000690@unknown@formal@none@1@S@However, blockade of the Ca(2+)-activated K+ channel is not associated with changes in cell-cycle gene activation, IL-2 production, IL-2R expression or B and T cell mitogenesis.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "Ca(2+)-activated") (:form . "Ca(2+)-activated")\n  (:end . 41) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "channel") (:form . "channel") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell-cycle") (:form . "cell-cycle") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 176)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x76.7.1) (:span 56 59)))\n (:nscopes ((:id . :x76.7.1) (:span 56 176)))\n (:identifiers (:sid . :s76.7) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000691@unknown@formal@none@1@S@These results imply that membrane potential changes secondary to the ligand-dependent opening of Ca(2+)-activated K+ channels are not involved in B and T lymphocyte activation and mitogenesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ligand-dependent") (:form . "ligand-dependent")\n  (:end . 85) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "opening") (:form . "opening") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "Ca(2+)-activated") (:form . "Ca(2+)-activated")\n  (:end . 113) (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 129) (:start . 126)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 142)\n  (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 175)\n  (:start . 165) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 191)\n  (:start . 180) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x76.8.2) (:span 14 19)))\n (:ncues ((:id . :x76.8.1) (:span 130 133)))\n (:hscopes ((:id . :x76.8.2) (:span 14 191)))\n (:nscopes ((:id . :x76.8.1) (:span 25 191)))\n (:identifiers (:sid . :s76.8) (:did . :|92043714|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000692@unknown@formal@none@1@S@Evaluation of the role of ligand and thermal activation of specific DNA binding by in vitro synthesized human glucocorticoid receptor.@(((:tag . "NN") (:stem . "evaluation") (:form . "Evaluation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "thermal") (:form . "thermal") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 124) (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s77.1) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000693@unknown@formal@none@1@S@We have used a DNA-binding/immunoprecipitation assay to analyze the capacity of human glucocorticoid receptor (hGR), generated in rabbit reticulocyte lysates, to bind DNA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA-binding/immunoprecipitation")\n  (:form . "DNA-binding/immunoprecipitation") (:end . 46) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 100) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s77.2) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000694@unknown@formal@none@1@S@In vitro translated hGR was indistinguishable from native hGR, as determined by migration on sodium dodecyl sulfate-polyacrylamide gels, sedimentation on sucrose density gradients, and reactivity with antipeptide antibodies generated against hGR.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 45) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "dodecyl") (:form . "dodecyl") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "sulfate-polyacrylamide")\n  (:form . "sulfate-polyacrylamide") (:end . 130) (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "gel") (:form . "gels") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "sedimentation") (:form . "sedimentation")\n  (:end . 150) (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sucrose") (:form . "sucrose") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "NNS") (:stem . "gradient") (:form . "gradients") (:end . 179)\n  (:start . 170) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 195)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "NN") (:stem . "antipeptide") (:form . "antipeptide") (:end . 212)\n  (:start . 201) (:id . 71))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 223)\n  (:start . 213) (:id . 72))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 233)\n  (:start . 224) (:id . 73))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 241)\n  (:start . 234) (:id . 74))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 245) (:start . 242)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s77.3) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000695@unknown@formal@none@1@S@In addition, cell-free synthesized hGR was capable of specific binding to glucocorticoid response element ( GRE ) -containing DNA fragments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "-containing") (:form . "-containing") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s77.4) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000696@unknown@formal@none@1@S@Using this assay system, we have evaluated the contributions of ligand binding and heat activation to DNA binding by these glucocorticoid receptors.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "contribution") (:form . "contributions")\n  (:end . 60) (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 137) (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s77.5) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000697@unknown@formal@none@1@S@In vitro translated hGR was capable of selective DNA binding even in the absence of glucocorticoid.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 98) (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x77.6.1) (:span 73 80)))\n (:nscopes ((:id . :x77.6.1) (:span 73 98)))\n (:identifiers (:sid . :s77.6) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000698@unknown@formal@none@1@S@Treatment with dexamethasone or the antiglucocorticoid RU486 had no additional effect on the DNA-binding capacity when receptor preparations were maintained at 0 C (no activation).@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "antiglucocorticoid") (:form . "antiglucocorticoid")\n  (:end . 54) (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "RU486") (:form . "RU486") (:end . 60) (:start . 55)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "preparation") (:form . "preparations") (:end . 140)\n  (:start . 128) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 145) (:start . 141)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 156)\n  (:start . 146) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 159) (:start . 157)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 161) (:start . 160)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 65))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 178)\n  (:start . 168) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x77.7.1) (:span 165 167)) ((:id . :x77.7.2) (:span 65 67)))\n (:nscopes ((:id . :x77.7.1) (:span 165 178))\n  ((:id . :x77.7.2) (:span 65 113)))\n (:identifiers (:sid . :s77.7) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000700@unknown@formal@none@1@S@Agonist (dexamethasone) was slightly more effective in supporting specific DNA binding than antagonist (RU486).@(((:tag . "NNP") (:stem . "Agonist") (:form . "Agonist") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "support") (:form . "supporting") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ru486") (:form . "RU486") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s77.9) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000701@unknown@formal@none@1@S@DNA binding by in vitro synthesized GR was blocked by the addition of sodium molybdate to the receptor preparations before steroid addition and thermal activation.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "molybdate") (:form . "molybdate") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "preparation") (:form . "preparations") (:end . 115)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "thermal") (:form . "thermal") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s77.10) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000702@unknown@formal@none@1@S@Addition of KCl resulted in less DNA binding either due to blockage of DNA-receptor complex formation or disruption of the complexes.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "KCl") (:form . "KCl") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "blockage") (:form . "blockage") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA-receptor") (:form . "DNA-receptor") (:end . 83)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x77.11.1) (:span 45 51 102 104)))\n (:hscopes ((:id . :x77.11.1) (:span 45 132)))\n (:identifiers (:sid . :s77.11) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000703@unknown@formal@none@1@S@The specificity of DNA binding by cell-free synthesized hGR was analyzed further by examining the abilities of various DNAs to compete for binding to a naturally occurring GRE found in the mouse mammary tumor virus-long terminal repeat.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "examine") (:form . "examining") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "ability") (:form . "abilities") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "dna") (:form . "DNAs") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 161)\n  (:start . 152) (:id . 67))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 202)\n  (:start . 195) (:id . 74))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 208)\n  (:start . 203) (:id . 75))\n ((:tag . "JJ") (:stem . "virus-long") (:form . "virus-long") (:end . 219)\n  (:start . 209) (:id . 76))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 228)\n  (:start . 220) (:id . 77))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 235)\n  (:start . 229) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s77.12) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000704@unknown@formal@none@1@S@Oligonucleotides containing the consensus GRE were the most efficient competitors, and fragments containing regulatory sequences from glucocorticoid-repressible genes were somewhat competitive, whereas single stranded oligonucleotides were unable to compete for mouse mammary tumor virus-long terminal repeat DNA binding, except when competitor was present at extremely high concentrations.@(((:tag . "NNS") (:stem . "oligonucleotide") (:form . "Oligonucleotides")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . 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5000705@unknown@formal@none@1@S@Together these studies indicate that hGR synthesized in rabbit reticulocyte lysates displays many of the same properties, including GRE-specific DNA binding, observed for glucocorticoid receptor present in cytosolic extracts of mammalian cells and tissues.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 75)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "gre-specific") (:form . "GRE-specific") (:end . 144)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 185) (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 194)\n  (:start . 186) (:id . 68))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 202)\n  (:start . 195) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 215)\n  (:start . 206) (:id . 71))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 224)\n  (:start . 216) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 237)\n  (:start . 228) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 243)\n  (:start . 238) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 255)\n  (:start . 248) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x77.14.1) (:span 23 36)))\n (:hscopes ((:id . :x77.14.1) (:span 23 255)))\n (:identifiers (:sid . :s77.14) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000706@unknown@formal@none@1@S@Similarities between the effects of dexamethasone and RU486 suggest that the antiglucocorticoid properties of RU486 do not occur at the level of specific DNA binding.@(((:tag . "NNS") (:stem . "similarity") (:form . "Similarities") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RU486") (:form . "RU486") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antiglucocorticoid") (:form . "antiglucocorticoid")\n  (:end . 95) (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RU486") (:form . "RU486") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 165)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x77.15.2) (:span 60 67)))\n (:ncues ((:id . :x77.15.1) (:span 119 122)))\n (:hscopes ((:id . :x77.15.2) (:span 60 165)))\n (:nscopes ((:id . :x77.15.1) (:span 119 165)))\n (:identifiers (:sid . :s77.15) (:did . :|92049367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000707@unknown@formal@none@1@S@One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cell-restricted") (:form . "cell-restricted")\n  (:end . 52) (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "kb-like") (:form . "kB-like") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "proto-enhancer") (:form . "proto-enhancer")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s78.1) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000708@unknown@formal@none@1@S@The inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-like sequence GGGATTTCACC as an essential cis-acting enhancer motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "Il-2") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "kb-like") (:form . "kB-like") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "GGGATTTCACC") (:form . "GGGATTTCACC") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 155)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s78.2) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000710@unknown@formal@none@1@S@In extracts of induced, Il-2 secreting El4 cells three individual protein factors bind to TCEd DNA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "Il-2") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "secreting") (:form . "secreting") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "el4") (:form . "El4") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s78.4) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000711@unknown@formal@none@1@S@The binding of the most prominent factor, named TCF-1 (T cell factor 1), is correlated with the proto-enhancer activity of TCEd.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 68)\n  (:start . 62) (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 86)\n  (:start . 76) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proto-enhancer") (:form . "proto-enhancer")\n  (:end . 110) (:start . 96) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 127) (:start . 123)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s78.5) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000712@unknown@formal@none@1@S@TCF-1 consists of two polypeptides of about 50 kD and 105 kD;@(((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "105") (:form . "105") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 61) (:start . 60)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s78.6) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000713@unknown@formal@none@1@S@the former seems to be related to the 50 kD polypeptide of NF-kB.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "former") (:form . "former") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 55)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x78.7.1) (:span 11 16)))\n (:hscopes ((:id . :x78.7.1) (:span 0 64)))\n (:identifiers (:sid . :s78.7) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000714@unknown@formal@none@1@S@Purified NF-kB is also able to bind to the TCEd, but TCF-1 binds stronger than NF-kB to TCEd DNA.@(((:tag . "VBN") (:stem . "purify") (:form . "Purified") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 58) (:start . 53)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 64) (:start . 59)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 73)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 92) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s78.8) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000715@unknown@formal@none@1@S@The conversion of the TCEd to a ' perfect ' NF-kB binding site leads to a tighter binding of NF-kB to TCEd DNA and , as a functional consequence, to the activity of the ' converted ' TCEd motifs in HeLa cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tced") (:form . "TCEd") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "perfect") (:form . "perfect") (:end . 41)\n  (:start . 34) (:id . 50))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 49) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "tight") (:form . "tighter") (:end . 81)\n  (:start . 74) (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 98) (:start . 93)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 106) (:start . 102)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 132)\n  (:start . 122) (:id . 69))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 144)\n  (:start . 133) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 161)\n  (:start . 153) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 76))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 170) (:start . 169)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "convert") (:form . "converted") (:end . 180)\n  (:start . 171) (:id . 78))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 182) (:start . 181)\n  (:id . 79))\n ((:tag . "NN") (:stem . "tced") (:form . "TCEd") (:end . 187) (:start . 183)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 194)\n  (:start . 188) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 202) (:start . 198)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 208)\n  (:start . 203) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s78.9) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000716@unknown@formal@none@1@S@Thus, the substitution of the underlined A residue to a C within the GGGATTTCACC motif abolishes its T cell-restricted activity and leads to its functioning in both El4 cells and HeLa cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 22)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "underline") (:form . "underlined") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GGGATTTCACC") (:form . "GGGATTTCACC") (:end . 80)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cell-restricted") (:form . "cell-restricted")\n  (:end . 118) (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "functioning") (:form . "functioning") (:end . 156)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "el4") (:form . "El4") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s78.10) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000717@unknown@formal@none@1@S@These results indicate that lymphocyte-specific factors binding to the TCEd are involved in the control of T cell specific-transcription of the Il-2 gene.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 47) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 55)\n  (:start . 48) (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "specific-transcription")\n  (:form . "specific-transcription") (:end . 136) (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "Il-2") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x78.11.1) (:span 14 27)))\n (:hscopes ((:id . :x78.11.1) (:span 14 153)))\n (:identifiers (:sid . :s78.11) (:did . :|92051383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000718@unknown@formal@none@1@S@Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.@(((:tag . "JJ") (:stem . "negative") (:form . "Negative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 45) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "65-kda") (:form . "65-kDa") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s79.1) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000720@unknown@formal@none@1@S@These differences in gene expression have not been molecularly defined.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "molecularly") (:form . "molecularly") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x79.3.1) (:span 42 45)))\n (:nscopes ((:id . :x79.3.1) (:span 0 70)))\n (:identifiers (:sid . :s79.3) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000721@unknown@formal@none@1@S@In THP-1 cells with restricted HIV expression, there is an absence of DNA-protein binding complex formation with the HIV-1 promoter-enhancer associated with markedly less viral RNA production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "promoter-enhancer") (:form . "promoter-enhancer")\n  (:end . 140) (:start . 123) (:id . 62))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 151)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 156) (:start . 152)\n  (:id . 64))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s79.4) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000722@unknown@formal@none@1@S@This absence of binding was localized to the NF-kappa B region of the HIV-1 enhancer;@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x79.5.1) (:span 5 12)))\n (:nscopes ((:id . :x79.5.1) (:span 5 23)))\n (:identifiers (:sid . :s79.5) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000723@unknown@formal@none@1@S@the 65-kDa plus 50-kDa NF-kappa B heterodimer was preferentially lost.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "65-kda") (:form . "65-kDa") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s79.6) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000724@unknown@formal@none@1@S@Adding purified NF-kappa B protein to nuclear extracts from cells with restricted expression overcomes this lack of binding.@(((:tag . "VBG") (:stem . "add") (:form . "Adding") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "VBZ") (:stem . "overcome") (:form . "overcomes") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x79.7.1) (:span 108 112)))\n (:nscopes ((:id . :x79.7.1) (:span 108 123)))\n (:identifiers (:sid . :s79.7) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000725@unknown@formal@none@1@S@In addition, treatment of these nuclear extracts with sodium deoxycholate restored their ability to form the heterodimer, suggesting the presence of an inhibitor of NF-kappa B activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "deoxycholate") (:form . "deoxycholate") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 88)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x79.8.1) (:span 122 132)))\n (:hscopes ((:id . :x79.8.1) (:span 122 184)))\n (:identifiers (:sid . :s79.8) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000726@unknown@formal@none@1@S@Furthermore, treatment of nuclear extracts from these cells that had restricted expression with lipopolysaccharide increased viral production and NF-kappa B activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "restrict") (:form . "restricted") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 114) (:start . 96) (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 141)\n  (:start . 131) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 165)\n  (:start . 157) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s79.9) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000727@unknown@formal@none@1@S@Antiserum specific for NF-kappa B binding proteins, but not c-rel-specific antiserum, disrupted heterodimer complex formation.@(((:tag . "NNP") (:stem . "Antiserum") (:form . "Antiserum") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "c-rel-specific") (:form . "c-rel-specific")\n  (:end . 74) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "antiserum") (:form . "antiserum") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "disrupt") (:form . "disrupted") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x79.10.1) (:span 56 59)))\n (:nscopes ((:id . :x79.10.1) (:span 56 84)))\n (:identifiers (:sid . :s79.10) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000728@unknown@formal@none@1@S@Thus, both NF-kappa B-binding complexes are needed for optimal viral transcription.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 50) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s79.11) (:did . :|92052106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000730@unknown@formal@none@1@S@Isolation of a candidate repressor/activator, NF-E1 (YY-1 , delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.@(((:tag . "NN") (:stem . "isolation") (:form . "Isolation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "repressor/activator")\n  (:form . "repressor/activator") (:end . 44) (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-E1") (:form . "NF-E1") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "YY-1") (:form . "YY-1") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 100) (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 141) (:start . 127) (:id . 66))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 153)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "e1") (:form . "E1") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s80.1) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000731@unknown@formal@none@1@S@We have determined that the developmental control of immunoglobulin kappa 3' enhancer ( kappa E3' ) activity is the result of the combined influence of positive- and negative-acting elements.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 67) (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "E3") (:form . "E3") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "positive-") (:form . "positive-") (:end . 161)\n  (:start . 152) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "negative-acting") (:form . "negative-acting")\n  (:end . 181) (:start . 166) (:id . 71))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s80.2) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000732@unknown@formal@none@1@S@We show that a central core in the kappa E3' enhancer is active at the pre-B-cell stage but is repressed by flanking negative-acting elements.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 53)\n  (:start . 45) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 63)\n  (:start . 57) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 66) (:start . 64)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pre-b-cell") (:form . "pre-B-cell") (:end . 81)\n  (:start . 71) (:id . 58))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "repress") (:form . "repressed") (:end . 104)\n  (:start . 95) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 116)\n  (:start . 108) (:id . 64))\n ((:tag . "JJ") (:stem . "negative-acting") (:form . "negative-acting")\n  (:end . 132) (:start . 117) (:id . 65))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 141)\n  (:start . 133) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s80.3) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000733@unknown@formal@none@1@S@The negative-acting sequences repress enhancer activity in a position- and orientation-independent manner at the pre-B-cell stage.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "negative-acting") (:form . "negative-acting")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "repress") (:form . "repress") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "position-") (:form . "position-") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "orientation-independent")\n  (:form . "orientation-independent") (:end . 98) (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 105)\n  (:start . 99) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 108) (:start . 106)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pre-b-cell") (:form . "pre-B-cell") (:end . 123)\n  (:start . 113) (:id . 56))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s80.4) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000734@unknown@formal@none@1@S@We have isolated a human cDNA clone encoding a zinc finger protein (NF-E1) that binds to the negative-acting segment of the kappa E3' enhancer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-E1") (:form . "NF-E1") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "negative-acting") (:form . "negative-acting")\n  (:end . 108) (:start . 93) (:id . 61))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 142)\n  (:start . 134) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s80.5) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000735@unknown@formal@none@1@S@This protein also binds to the immunoglobulin heavy-chain enhancer mu E1 site.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 45) (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "e1") (:form . "E1") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s80.6) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000736@unknown@formal@none@1@S@NF-E1 is encoded by the same gene as the YY-1 protein, which binds to the adeno-associated virus P5 promoter.@(((:tag . "NNP") (:stem . "NF-E1") (:form . "NF-E1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "yy-1") (:form . "YY-1") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adeno-associated") (:form . "adeno-associated")\n  (:end . 90) (:start . 74) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p5") (:form . "P5") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s80.7) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000737@unknown@formal@none@1@S@NF-E1 is also the human homologue of the mouse delta protein, which binds to ribosomal protein gene promoters.@(((:tag . "NNP") (:stem . "NF-E1") (:form . "NF-E1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ribosomal") (:form . "ribosomal") (:end . 86)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s80.8) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000738@unknown@formal@none@1@S@The predicted amino acid sequence of this protein contains features characteristic of transcriptional activators as well as transcriptional repressors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 82) (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 54))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 139) (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "repressor") (:form . "repressors") (:end . 150)\n  (:start . 140) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s80.9) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000740@unknown@formal@none@1@S@The apparent dual function of this protein is discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x80.11.1) (:span 4 12)))\n (:hscopes ((:id . :x80.11.1) (:span 4 42)))\n (:identifiers (:sid . :s80.11) (:did . :|92052179|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000741@unknown@formal@none@1@S@Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains.@(((:tag . "NNP") (:stem . "Clone") (:form . "Clone") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "factor-induced") (:form . "factor-induced")\n  (:end . 101) (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 141)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s81.1) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000742@unknown@formal@none@1@S@We report the structure and regulation of a gene represented by clone pAT 133, which is induced upon transition from a resting state (G0) through the early phase of the cell cycle (G1).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 111)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "resting") (:form . "resting") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "G0") (:form . "G0") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 68))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 145)\n  (:start . 138) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 155)\n  (:start . 150) (:id . 71))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 161)\n  (:start . 156) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 173) (:start . 169)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 179)\n  (:start . 174) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 181) (:start . 180)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 183) (:start . 181)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s81.2) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000743@unknown@formal@none@1@S@The pAT 133 gene is immediately induced, with FOS-like kinetics, in human T cells and in fibroblasts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "fos-like") (:form . "FOS-like") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 100)\n  (:start . 89) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s81.3) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000744@unknown@formal@none@1@S@Primary structure analysis showed that the encoded protein contains three tandem zinc-finger sequences of the type Cys2-Xaa12-His2.@(((:tag . "JJ") (:stem . "primary") (:form . "Primary") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 33) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 92)\n  (:start . 81) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cys2-xaa12-his2") (:form . "Cys2-Xaa12-His2")\n  (:end . 130) (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s81.4) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000745@unknown@formal@none@1@S@This zinc-finger region, which is thought to bind DNA in a sequence-specific manner, is similar (greater than 80% on the amino acid level) to two previously described transcription factors pAT 225/EGR1 and pAT 591/EGR2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 76) (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 131) (:start . 127)\n  (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 145) (:start . 142)\n  (:id . 71))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 156)\n  (:start . 146) (:id . 72))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 166)\n  (:start . 157) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 180) (:start . 167) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 188)\n  (:start . 181) (:id . 75))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 192) (:start . 189)\n  (:id . 76))\n ((:tag . "NN") (:stem . "225/egr1") (:form . "225/EGR1") (:end . 201)\n  (:start . 193) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 78))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 209) (:start . 206)\n  (:id . 79))\n ((:tag . "NN") (:stem . "591/egr2") (:form . "591/EGR2") (:end . 218)\n  (:start . 210) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x81.5.1) (:span 34 41)))\n (:hscopes ((:id . :x81.5.1) (:span 25 83)))\n (:identifiers (:sid . :s81.5) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000746@unknown@formal@none@1@S@Except for the conserved zinc-finger domains, the amino acid sequences of the three proteins are distinct.@(((:tag . "IN") (:stem . "except") (:form . "Except") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s81.6) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000747@unknown@formal@none@1@S@This structural similarity suggests that the pAT 133 gene encodes a transcription factor with a specific biological function.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x81.7.1) (:span 27 35)))\n (:hscopes ((:id . :x81.7.1) (:span 27 124)))\n (:identifiers (:sid . :s81.7) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000748@unknown@formal@none@1@S@Comparing the regulation of these related zinc-finger-encoding genes showed coordinate induction upon mitogenic stimulation of resting T lymphocytes and of resting fibroblasts.@(((:tag . "VBG") (:stem . "compare") (:form . "Comparing") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "zinc-finger-encoding")\n  (:form . "zinc-finger-encoding") (:end . 62) (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 75) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 86)\n  (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 101) (:start . 97)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 111)\n  (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 134)\n  (:start . 127) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 148)\n  (:start . 137) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 163)\n  (:start . 156) (:id . 62))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 175)\n  (:start . 164) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s81.8) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000750@unknown@formal@none@1@S@In human histiocytic U937 cells mRNA of clone pAT 133 was constitutively expressed, whereas mRNA of pAT 225/EGR1 was induced upon induction of terminal differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "histiocytic") (:form . "histiocytic") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 72) (:start . 58) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "225/egr1") (:form . "225/EGR1") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 167) (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s81.10) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000751@unknown@formal@none@1@S@In contrast mRNA representing pAT 591/EGR2 was not expressed in these cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "591/egr2") (:form . "591/EGR2") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x81.11.1) (:span 47 50)))\n (:nscopes ((:id . :x81.11.1) (:span 12 75)))\n (:identifiers (:sid . :s81.11) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000752@unknown@formal@none@1@S@This difference in gene regulation suggests distinct biological roles in the control of cell proliferation for the respective proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x81.12.1) (:span 35 43)))\n (:hscopes ((:id . :x81.12.1) (:span 35 134)))\n (:identifiers (:sid . :s81.12) (:did . :|92052214|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000753@unknown@formal@none@1@S@cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.@(((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 42) (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s82.1) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000754@unknown@formal@none@1@S@We demonstrate that JunD, a component of the AP-1 transcription factor complex, activates transcription of the human proenkephalin gene in a fashion that is completely dependent upon the cAMP-dependent protein kinase, protein kinase A.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 130) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 148)\n  (:start . 141) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 167)\n  (:start . 157) (:id . 68))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 177)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 182) (:start . 178)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 201) (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 209)\n  (:start . 202) (:id . 73))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 216)\n  (:start . 210) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 217) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 225)\n  (:start . 218) (:id . 76))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 232)\n  (:start . 226) (:id . 77))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 234) (:start . 233)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s82.2) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000755@unknown@formal@none@1@S@Activation of proenkephalin transcription by JunD is dependent upon a previously characterized cAMP-, phorbol ester- , and Ca(2+)-inducible enhancer, and JunD is shown to bind the enhancer as a homodimer.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "proenkephalin") (:form . "proenkephalin")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 94) (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "camp-") (:form . "cAMP-") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "ester-") (:form . "ester-") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "Ca(2+)-inducible") (:form . "Ca(2+)-inducible")\n  (:end . 139) (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 148)\n  (:start . 140) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 167)\n  (:start . 162) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 203)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s82.3) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000756@unknown@formal@none@1@S@Another component of the AP-1 transcription complex, JunB, is shown to inhibit activation mediated by JunD.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s82.4) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000757@unknown@formal@none@1@S@As a homodimer JunB is unable to bind the enhancer; however in the presence of c-Fos, high-affinity binding is observed.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 14)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "junb") (:form . "JunB") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 99) (:start . 86) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x82.5.1) (:span 23 29)))\n (:nscopes ((:id . :x82.5.1) (:span 23 50)))\n (:identifiers (:sid . :s82.5) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000758@unknown@formal@none@1@S@Furthermore, JunD is shown to activate transcription of genes linked to both cAMP and phorbol ester response elements in a protein kinase A-dependent fashion, further blurring the distinction between these response elements.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 68) (:start . 62)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 130)\n  (:start . 123) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "JJ") (:stem . "a-dependent") (:form . "A-dependent") (:end . 149)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 166)\n  (:start . 159) (:id . 68))\n ((:tag . "VBG") (:stem . "blur") (:form . "blurring") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "distinction") (:form . "distinction") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 199)\n  (:start . 192) (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 205)\n  (:start . 200) (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 214)\n  (:start . 206) (:id . 74))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 223)\n  (:start . 215) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s82.6) (:did . :|92052243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000760@unknown@formal@none@1@S@Glucocorticoid resistance in chronic asthma.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s83.1) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000761@unknown@formal@none@1@S@Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pharmacokinetic") (:form . "pharmacokinetics")\n  (:end . 31) (:start . 15) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 47) (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 46))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 72) (:start . 57) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 88)\n  (:start . 78) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 102)\n  (:start . 92) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 108)\n  (:start . 103) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 129) (:start . 116) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 148) (:start . 133) (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 157)\n  (:start . 152) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s83.2) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000762@unknown@formal@none@1@S@A total of 37 chronic, severe, nonsmoking asthmatic patients with documented reversible airways obstruction were classified as glucocorticoid-sensitive or -resistant on the basis of changes in FEV1, FVC, and peak expiratory flow (PEF) after oral prednisolone.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nonsmoking") (:form . "nonsmoking") (:end . 41)\n  (:start . 31) (:id . 50))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "airway") (:form . "airways") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "obstruction") (:form . "obstruction") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "classify") (:form . "classified") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "glucocorticoid-sensitive")\n  (:form . "glucocorticoid-sensitive") (:end . 151) (:start . 127) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "-resistant") (:form . "-resistant") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 65))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 178)\n  (:start . 173) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 189)\n  (:start . 182) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "FEV1") (:form . "FEV1") (:end . 197) (:start . 193)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "FVC") (:form . "FVC") (:end . 202) (:start . 199)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "peak") (:form . "peak") (:end . 212) (:start . 208)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "expiratory") (:form . "expiratory") (:end . 223)\n  (:start . 213) (:id . 76))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 228) (:start . 224)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 230) (:start . 229)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "PEF") (:form . "PEF") (:end . 233) (:start . 230)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 80))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 240)\n  (:start . 235) (:id . 81))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 245) (:start . 241)\n  (:id . 82))\n ((:tag . "NN") (:stem . "prednisolone") (:form . "prednisolone") (:end . 258)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s83.3) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000763@unknown@formal@none@1@S@The resistant patients showed no significant improvements in airflow limitation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "improvement") (:form . "improvements") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "airflow") (:form . "airflow") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "limitation") (:form . "limitation") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x83.4.1) (:span 30 32)))\n (:nscopes ((:id . :x83.4.1) (:span 30 79)))\n (:identifiers (:sid . :s83.4) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000764@unknown@formal@none@1@S@Phytohemagglutinin ( PHA ) -induced proliferation of peripheral blood T lymphocytes from the sensitive but not the resistant asthmatic patients was significantly (p less than 0.01) inhibited by dexamethasone (10(-7) mol/L), reflecting a shift of the dose-response curve.@(((:tag . "NNP") (:stem . "Phytohemagglutinin") (:form . "Phytohemagglutinin")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "-induced") (:form . "-induced") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 161) (:start . 148) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 190)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 207) (:start . 194) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . "RB") (:stem . "10(-7)") (:form . "10(-7)") (:end . 215)\n  (:start . 209) (:id . 74))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 221)\n  (:start . 216) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 234)\n  (:start . 224) (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 236) (:start . 235)\n  (:id . 79))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 242)\n  (:start . 237) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "dose-response") (:form . "dose-response")\n  (:end . 263) (:start . 250) (:id . 83))\n ((:tag . "NN") (:stem . "curve") (:form . "curve") (:end . 269)\n  (:start . 264) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x83.5.1) (:span 107 110)))\n (:nscopes ((:id . :x83.5.1) (:span 107 124)))\n (:identifiers (:sid . :s83.5) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5000766@unknown@formal@none@1@S@No differences were observed between six of the sensitive and resistant patients in the clearance of plasma prednisolone derived from orally administered prednisone.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "prednisolone") (:form . "prednisolone") (:end . 120)\n  (:start . 108) (:id . 59))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "RB") (:stem . "orally") (:form . "orally") (:end . 140)\n  (:start . 134) (:id . 62))\n ((:tag . "VBN") (:stem . "administer") (:form . "administered") (:end . 153)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "prednisone") (:form . "prednisone") (:end . 164)\n  (:start . 154) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x83.7.1) (:span 0 2)))\n (:nscopes ((:id . :x83.7.1) (:span 0 164)))\n (:identifiers (:sid . :s83.7) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000767@unknown@formal@none@1@S@Peripheral blood mononuclear cell glucocorticoid receptors were also characterized in five sensitive and seven resistant patients.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 48) (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 58)\n  (:start . 49) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 63) (:start . 59)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 82) (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 51))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 100)\n  (:start . 91) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 110)\n  (:start . 105) (:id . 55))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 120)\n  (:start . 111) (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 129)\n  (:start . 121) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s83.8) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000768@unknown@formal@none@1@S@The numbers and binding affinities of these receptors could not account for the observed difference in the susceptibility of these cells to functional inhibition by dexamethasone in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 121) (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 161)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 178) (:start . 165) (:id . 67))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x83.9.1) (:span 60 63)))\n (:nscopes ((:id . :x83.9.1) (:span 60 187)))\n (:identifiers (:sid . :s83.9) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000770@unknown@formal@none@1@S@This lack of sensitivity is unexplained but is not attributable to abnormalities of cellular glucocorticoid receptors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unexplained") (:form . "unexplained") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 63)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 80)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 107) (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x83.11.1) (:span 47 50)) ((:id . :x83.11.2) (:span 5 9)))\n (:nscopes ((:id . :x83.11.1) (:span 47 117))\n  ((:id . :x83.11.2) (:span 5 24)))\n (:identifiers (:sid . :s83.11) (:did . :|92060325|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000771@unknown@formal@none@1@S@Regulation of interleukin-1 beta production by glucocorticoids in human monocytes: the mechanism of action depends on the activation signal.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 62) (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 81)\n  (:start . 72) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 139)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s84.1) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000772@unknown@formal@none@1@S@Glucocorticoids are known to downregulate interleukin-1 beta production in monocytic cells by two different mechanims: direct inhibition of the gene transcription and destabilization of the preformed interleukin-1 beta mRNA.@(((:tag . "NNS") (:stem . "glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VB") (:stem . "downregulate") (:form . "downregulate") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 55) (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "NNS") (:stem . "mechanim") (:form . "mechanims") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 118) (:start . 117)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 125)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 136)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 162) (:start . 149) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "destabilization") (:form . "destabilization")\n  (:end . 182) (:start . 167) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "preformed") (:form . "preformed") (:end . 199)\n  (:start . 190) (:id . 68))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 213) (:start . 200) (:id . 69))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 218) (:start . 214)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 223) (:start . 219)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s84.2) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000773@unknown@formal@none@1@S@Now we have examined the effect of the nature of the monocyte activating signal on these two inhibitory mechanims.@(((:tag . "RB") (:stem . "now") (:form . "Now") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanim") (:form . "mechanims") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s84.3) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000774@unknown@formal@none@1@S@When human monocytes were preincubated with dexamethasone for 1 hour and then stimulated either with bacterial lipopolysaccharide or phorbol myristate, it was found that dexamethasone inhibited the lipopolysaccharide-induced interleukin-1 beta protein production, but the phorbol myristate-induced production was increased 3-10 fold.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 57) (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 129) (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 140)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 150)\n  (:start . 141) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 183) (:start . 170) (:id . 67))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 193)\n  (:start . 184) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 224) (:start . 198)\n  (:id . 70))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 238) (:start . 225) (:id . 71))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 243) (:start . 239)\n  (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 251)\n  (:start . 244) (:id . 73))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 262)\n  (:start . 252) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 263) (:start . 262)\n  (:id . 75))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 267) (:start . 264)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 271) (:start . 268)\n  (:id . 77))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 279)\n  (:start . 272) (:id . 78))\n ((:tag . "JJ") (:stem . "myristate-induced") (:form . "myristate-induced")\n  (:end . 297) (:start . 280) (:id . 79))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 308)\n  (:start . 298) (:id . 80))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 312) (:start . 309)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 322)\n  (:start . 313) (:id . 82))\n ((:tag . "CD") (:stem . "3-10") (:form . "3-10") (:end . 327) (:start . 323)\n  (:id . 83))\n ((:tag . "RB") (:stem . "fold") (:form . "fold") (:end . 332) (:start . 328)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 333) (:start . 332)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s84.4) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000775@unknown@formal@none@1@S@This difference was also seen at the mRNA level.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s84.5) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000776@unknown@formal@none@1@S@When dexamethasone was added to the cultures 3 hours after the stimulators, it clearly decreased the interleukin-1 beta mRNA levels regardless of the stimulator used (although the effect was clearly weaker on the PMA-induced mRNA).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "stimulator") (:form . "stimulators") (:end . 74)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 114) (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stimulator") (:form . "stimulator") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 186)\n  (:start . 180) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 198)\n  (:start . 191) (:id . 73))\n ((:tag . "JJR") (:stem . "weak") (:form . "weaker") (:end . 205)\n  (:start . 199) (:id . 74))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 208) (:start . 206)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 224)\n  (:start . 213) (:id . 77))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 229) (:start . 225)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 230) (:start . 229)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s84.6) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000777@unknown@formal@none@1@S@Thus these data suggest that the phorbol myristate-induced signal (prolonged protein kinase C activation?) can not be inhibited by prior incubation with dexamethasone and it also protects the induced mRNA for the degradative action of dexamethasone.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "myristate-induced") (:form . "myristate-induced")\n  (:end . 58) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "prolong") (:form . "prolonged") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 127)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 166) (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 187)\n  (:start . 179) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 199)\n  (:start . 192) (:id . 73))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 208) (:start . 205)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "degradative") (:form . "degradative") (:end . 224)\n  (:start . 213) (:id . 77))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 79))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 248) (:start . 235) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x84.7.2) (:span 16 23)))\n (:ncues ((:id . :x84.7.1) (:span 107 114)))\n (:hscopes ((:id . :x84.7.2) (:span 16 248)))\n (:nscopes ((:id . :x84.7.1) (:span 29 166)))\n (:identifiers (:sid . :s84.7) (:did . :|92062170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000778@unknown@formal@none@1@S@Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 33) (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 44)\n  (:start . 34) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 53)\n  (:start . 45) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 63) (:start . 59)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 128) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 134)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 139) (:start . 135)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 141) (:start . 140)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s85.1) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000780@unknown@formal@none@1@S@One of the factors bound to a novel dyad symmetrical sequence.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dyad") (:form . "dyad") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "symmetrical") (:form . "symmetrical") (:end . 52)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s85.3) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000781@unknown@formal@none@1@S@This sequence is well conserved in various HIV-1 isolates and partial homology was found with the promoter region of the human retinoblastoma gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 141) (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s85.4) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000782@unknown@formal@none@1@S@Similar DNA binding activity was detected in a variety of virus-uninfected human T cell lines and HeLa cells by means of a gel mobility shift assay.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "virus-uninfected") (:form . "virus-uninfected")\n  (:end . 74) (:start . 58) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 135)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s85.5) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000783@unknown@formal@none@1@S@The other factor bound to a putative AP-1 recognition sequence predicted for the HIV-1 NRE.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x85.6.1) (:span 28 36)))\n (:hscopes ((:id . :x85.6.1) (:span 28 62)))\n (:identifiers (:sid . :s85.6) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000784@unknown@formal@none@1@S@However, this factor did not bind to a typical AP-1 site.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x85.7.1) (:span 25 28)))\n (:nscopes ((:id . :x85.7.1) (:span 25 56)))\n (:identifiers (:sid . :s85.7) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000785@unknown@formal@none@1@S@The insertion of multiple copies of the binding site for the former or latter factor into a heterologous promoter reduced the promoter activity to one-tenth or one-third, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 32) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "former") (:form . "former") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 104)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "one-tenth") (:form . "one-tenth") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "one-third") (:form . "one-third") (:end . 169)\n  (:start . 160) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 183)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s85.8) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000786@unknown@formal@none@1@S@Thus, each factor may function as a novel negative regulator of transcription.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x85.9.1) (:span 18 21)))\n (:hscopes ((:id . :x85.9.1) (:span 18 77)))\n (:identifiers (:sid . :s85.9) (:did . :|92066454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000787@unknown@formal@none@1@S@Constitutive activation of NF-kB in human thymocytes.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s86.1) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000788@unknown@formal@none@1@S@NF-kB is a eukaryotic transcription regulatory factor.@(((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s86.2) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000790@unknown@formal@none@1@S@Treatment of T cells with mitogens (phorbol esters) or cytokines (TNF alpha) induces NF-kB nuclear translocation and the subsequent expression of NF-kB dependent T cell genes.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 112) (:start . 99) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 131)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 161)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s86.4) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000791@unknown@formal@none@1@S@Here we examined the activation of NF-kB in human T cell thymic progenitors.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s86.5) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000792@unknown@formal@none@1@S@We report differences in (Ca2+)i requirement for NF-kB activation in thymocytes as compared to mature T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ca2+)i") (:form . "Ca2+)i") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s86.6) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000793@unknown@formal@none@1@S@Furthermore, our results indicated that thymocytes have a constitutively active form of NF-kB, suggesting that they are activated in vivo.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 72) (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x86.7.1) (:span 95 105)) ((:id . :x86.7.2) (:span 25 39)))\n (:hscopes ((:id . :x86.7.1) (:span 95 137)) ((:id . :x86.7.2) (:span 25 93)))\n (:identifiers (:sid . :s86.7) (:did . :|92068245|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000794@unknown@formal@none@1@S@The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 83) (:start . 47)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 119) (:start . 104) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s87.1) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000795@unknown@formal@none@1@S@Terminal differentiation of the leukemic cell lines U-937 and HL-60 by 12-O-tetradecanoylphorbol-13-acetate is accompanied by marked changes in gene expression.@(((:tag . "JJ") (:stem . "terminal") (:form . "Terminal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 107) (:start . 71)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 122)\n  (:start . 111) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 132)\n  (:start . 126) (:id . 57))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 140)\n  (:start . 133) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s87.2) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000796@unknown@formal@none@1@S@In this study, we demonstrate that the expression of jun and fos gene family members is induced with variable kinetics during 12-O-tetradecanoylphorbol-13-acetate induced differentiation, with c-jun expression best paralleling differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 76)\n  (:start . 70) (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 162) (:start . 126)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 170)\n  (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 186) (:start . 171) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 192) (:start . 188)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 198)\n  (:start . 193) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 209)\n  (:start . 199) (:id . 70))\n ((:tag . "RBS") (:stem . "well") (:form . "best") (:end . 214) (:start . 210)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "paralleling") (:form . "paralleling") (:end . 226)\n  (:start . 215) (:id . 72))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 242) (:start . 227) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s87.3) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000797@unknown@formal@none@1@S@The generation of AP-1 complexes, as measured by DNA binding activity, closely parallels morphological differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "VBZ") (:stem . "parallel") (:form . "parallels") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "morphological") (:form . "morphological")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 118) (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s87.4) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000798@unknown@formal@none@1@S@Furthermore, the ability of these complexes to regulate gene expression is demonstrated by increased transcription from an AP-1 driven reporter construct and marked increases in the expression of endogenous AP-1 regulated genes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 87)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "driven") (:form . "driven") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 164)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 174)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 192)\n  (:start . 182) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 206)\n  (:start . 196) (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 211) (:start . 207)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 221)\n  (:start . 212) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 227)\n  (:start . 222) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s87.5) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000800@unknown@formal@none@1@S@This tight correlation between c-jun expression, the generation of AP-1 activity, and differentiation suggests a critical role for this gene and transcriptional complex during this process.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 101) (:start . 86) (:id . 56))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 160) (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 168)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 175)\n  (:start . 169) (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 180) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 188)\n  (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x87.7.1) (:span 102 110)))\n (:hscopes ((:id . :x87.7.1) (:span 102 188)))\n (:identifiers (:sid . :s87.7) (:did . :|92088960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000801@unknown@formal@none@1@S@TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers.@(((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 24) (:start . 11) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 139)\n  (:start . 130) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s88.1) (:did . :|92103005|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000802@unknown@formal@none@1@S@We have recently identified and cloned TCF-1, a T cell-specific transcription factor with specificity for the AACAAAG motif in the CD3 epsilon enhancer and for the TTCAAAG motif in the TCR alpha enhancer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 63) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "AACAAAG") (:form . "AACAAAG") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 151)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TTCAAAG") (:form . "TTCAAAG") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 194)\n  (:start . 189) (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 203)\n  (:start . 195) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s88.2) (:did . :|92103005|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000803@unknown@formal@none@1@S@TCF-1 belongs to the family of transcription-regulating proteins which share a region of homology termed the HMG-box.@(((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcription-regulating")\n  (:form . "transcription-regulating") (:end . 55) (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hmg-box") (:form . "HMG-box") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s88.3) (:did . :|92103005|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000804@unknown@formal@none@1@S@Here, we show by gel retardation analysis that TCF-1 specifically recognizes the T beta 5 element of the TCR beta enhancer and the T delta 7 element of the TCR delta enhancer.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 32)\n  (:start . 21) (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 140) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 148)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 159) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 165)\n  (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 174)\n  (:start . 166) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s88.4) (:did . :|92103005|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000805@unknown@formal@none@1@S@Comparison of the sequences of all elements recognized by TCF-1 defines a consensus motif A/T A/T C A A/G A G.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCF-1") (:form . "TCF-1") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "define") (:form . "defines") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "A/T") (:form . "A/T") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "A/T") (:form . "A/T") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "A/G") (:form . "A/G") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s88.5) (:did . :|92103005|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000806@unknown@formal@none@1@S@These observations imply that TCF-1 is involved in the control of several T cell-specific genes and might thus play an important role in the establishment and maintenance of the mature T cell phenotype.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "establishment") (:form . "establishment")\n  (:end . 154) (:start . 141) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 170)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 184)\n  (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 186) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 191) (:start . 187)\n  (:id . 73))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 201)\n  (:start . 192) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x88.6.1) (:span 100 105)) ((:id . :x88.6.2) (:span 19 24)))\n (:hscopes ((:id . :x88.6.1) (:span 100 201))\n  ((:id . :x88.6.2) (:span 19 201)))\n (:identifiers (:sid . :s88.6) (:did . :|92103005|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000807@unknown@formal@none@1@S@The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 78)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 105) (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s89.1) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000808@unknown@formal@none@1@S@Regulation of replicative functions in the Epstein-Barr virus (EBV) genome is mediated through activation of a virally encoded transcription factor, Z (BZLF1).@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "RB") (:stem . "virally") (:form . "virally") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Z") (:form . "Z") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s89.2) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000810@unknown@formal@none@1@S@Here we demonstrate that the c-myb proto-oncogene product, which is itself a DNA-binding protein and transcriptional transactivator, can interact synergistically with Z in activating the BMRF1 promoter in Jurkat cells (a T-cell line) or Raji cells (an EBV-positive B-cell), whereas the c-myb gene product by itself has little effect.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . 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"the") (:end . 285) (:start . 282)\n  (:id . 89))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 291)\n  (:start . 286) (:id . 90))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 296) (:start . 292)\n  (:id . 91))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 304)\n  (:start . 297) (:id . 92))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 307) (:start . 305)\n  (:id . 93))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 314)\n  (:start . 308) (:id . 94))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 318) (:start . 315)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 325)\n  (:start . 319) (:id . 96))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 332)\n  (:start . 326) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5000811@unknown@formal@none@1@S@The simian virus 40 early promoter is also synergistically activated by the Z/c-myb combination.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 58) (:start . 43) (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Z/c-myb") (:form . "Z/c-myb") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s89.5) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000812@unknown@formal@none@1@S@Synergistic transactivation of the BMRF1 promoter by the Z/c-myb combination appears to involve direct binding by the Z protein but not the c-myb protein.@(((:tag . "JJ") (:stem . "synergistic") (:form . "Synergistic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bmrf1") (:form . "BMRF1") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Z/c-myb") (:form . "Z/c-myb") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Z") (:form . "Z") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x89.6.2) (:span 77 84)))\n (:ncues ((:id . :x89.6.1) (:span 132 135)))\n (:hscopes ((:id . :x89.6.2) (:span 0 153)))\n (:nscopes ((:id . :x89.6.1) (:span 132 153)))\n (:identifiers (:sid . :s89.6) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000813@unknown@formal@none@1@S@A 30-bp sequence in the BMRF1 promoter which contains a Z binding site (a consensus AP-1 site) is sufficient to transfer high-level lymphoid-specific responsiveness to the Z/c-myb combination to a heterologous promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "30-bp") (:form . "30-bp") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bmrf1") (:form . "BMRF1") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Z") (:form . "Z") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 108)\n  (:start . 98) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "VB") (:stem . "transfer") (:form . "transfer") (:end . 120)\n  (:start . 112) (:id . 64))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 131)\n  (:start . 121) (:id . 65))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 149) (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 164) (:start . 150) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Z/c-myb") (:form . "Z/c-myb") (:end . 179)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 209)\n  (:start . 197) (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 218)\n  (:start . 210) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s89.7) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000814@unknown@formal@none@1@S@That the c-myb oncogene product can interact synergistically with an EBV-encoded member of the leucine zipper protein family suggests c-myb is likely to engage in similar interactions with cellularly encoded transcription factors.@(((:tag . "IN") (:stem . "that") (:form . "That") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ebv-encoded") (:form . "EBV-encoded") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "leucine") (:form . "leucine") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "zipper") (:form . "zipper") (:end . 109)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "VB") (:stem . "engage") (:form . "engage") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 170)\n  (:start . 163) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 183)\n  (:start . 171) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 69))\n ((:tag . "RB") (:stem . "cellularly") (:form . "cellularly") (:end . 199)\n  (:start . 189) (:id . 70))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 207)\n  (:start . 200) (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 221) (:start . 208) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 229)\n  (:start . 222) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x89.8.1) (:span 143 149))\n  ((:id . :x89.8.2) (:span 125 133)))\n (:hscopes ((:id . :x89.8.1) (:span 134 229))\n  ((:id . :x89.8.2) (:span 125 229)))\n (:identifiers (:sid . :s89.8) (:did . :|92107162|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000815@unknown@formal@none@1@S@The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "29-kda") (:form . "29-kDa") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "thrombin-activated") (:form . "thrombin-activated")\n  (:end . 56) (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 72)\n  (:start . 63) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "JJ") (:stem . "receptor-related") (:form . "receptor-related")\n  (:end . 115) (:start . 99) (:id . 55))\n ((:tag . "JJ") (:stem . "27-kda") (:form . "27-kDa") (:end . 122)\n  (:start . 116) (:id . 56))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 127) (:start . 123)\n  (:id . 57))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 133)\n  (:start . 128) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s90.1) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000816@unknown@formal@none@1@S@Thrombin plays a critical role in platelet activation, hemostasis, and thrombosis.@(((:tag . "NNP") (:stem . "Thrombin") (:form . "Thrombin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hemostasis") (:form . "hemostasis") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thrombosis") (:form . "thrombosis") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s90.2) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000817@unknown@formal@none@1@S@Cellular activation by thrombin leads to the phosphorylation of multiple proteins, most of which are unidentified.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s90.3) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000818@unknown@formal@none@1@S@We have characterized several 29-kDa proteins that are rapidly phosphorylated following exposure of intact human platelets to thrombin.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "29-kda") (:form . "29-kDa") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 77) (:start . 63) (:id . 51))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s90.4) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000820@unknown@formal@none@1@S@Cellular activation by thrombin led to a marked shift in the proportion of protein from the 27-kDa unphosphorylated form to the 29-kDa phosphoprotein species.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "27-kda") (:form . "27-kDa") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "unphosphorylated") (:form . "unphosphorylated")\n  (:end . 115) (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "29-kda") (:form . "29-kDa") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 149) (:start . 135) (:id . 64))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s90.6) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000821@unknown@formal@none@1@S@Using this antibody, we isolated and sequenced a human cDNA clone encoding a protein that was identical to the mammalian 27-kDa heat shock protein (HSP27), a protein of uncertain function that is known to be phosphorylated to several forms and to be transcriptionally induced by estrogen.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "sequence") (:form . "sequenced") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "27-kda") (:form . "27-kDa") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HSP27") (:form . "HSP27") (:end . 153)\n  (:start . 148) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 165)\n  (:start . 158) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "uncertain") (:form . "uncertain") (:end . 178)\n  (:start . 169) (:id . 74))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 187)\n  (:start . 179) (:id . 75))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 195) (:start . 193)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 201)\n  (:start . 196) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 79))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 207) (:start . 205)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 222) (:start . 208) (:id . 81))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 225) (:start . 223)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 233)\n  (:start . 226) (:id . 83))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 239)\n  (:start . 234) (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 246) (:start . 244)\n  (:id . 86))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 249) (:start . 247)\n  (:id . 87))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 267) (:start . 250) (:id . 88))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 275)\n  (:start . 268) (:id . 89))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 278) (:start . 276)\n  (:id . 90))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 287)\n  (:start . 279) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s90.7) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000822@unknown@formal@none@1@S@The 29-kDa proteins were confirmed to be phosphorylated forms of HSP27 by immunoprecipitation studies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "29-kda") (:form . "29-kDa") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 55) (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hsp27") (:form . "HSP27") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 93) (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s90.8) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000823@unknown@formal@none@1@S@Thus, the " estrogen receptor-related protein " is HSP27, and the three major 29-kDa proteins phosphorylated in thrombin-activated platelets are forms of HSP27.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 20)\n  (:start . 12) (:id . 46))\n ((:tag . "JJ") (:stem . "receptor-related") (:form . "receptor-related")\n  (:end . 37) (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hsp27") (:form . "HSP27") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "29-kda") (:form . "29-kDa") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 108) (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "thrombin-activated") (:form . "thrombin-activated")\n  (:end . 130) (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "hsp27") (:form . "HSP27") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s90.9) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000824@unknown@formal@none@1@S@These data suggest a role for HSP27 in the signal transduction events of platelet activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hsp27") (:form . "HSP27") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 62)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x90.10.1) (:span 11 18)))\n (:hscopes ((:id . :x90.10.1) (:span 11 92)))\n (:identifiers (:sid . :s90.10) (:did . :|92107919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000825@unknown@formal@none@1@S@Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 58)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "homeodomain") (:form . "homeodomain") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s91.1) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000826@unknown@formal@none@1@S@Dimerization among transcription factors has become a recurrent theme in the regulation of eukaryotic gene expression.@(((:tag . "NN") (:stem . "dimerization") (:form . "Dimerization") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 32) (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "become") (:form . "become") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "theme") (:form . "theme") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s91.2) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000827@unknown@formal@none@1@S@Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is a homeodomain-containing protein that functions as a dimer.@(((:tag . "NNP") (:stem . "Hepatocyte") (:form . "Hepatocyte") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hnf-1") (:form . "HNF-1") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "homeodomain-containing")\n  (:form . "homeodomain-containing") (:end . 75) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s91.3) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000828@unknown@formal@none@1@S@A dimerization cofactor of HNF-1 alpha (DCoH) was identified that displayed a restricted tissue distribution and did not bind to DNA, but , rather, selectively stabilized HNF-1 alpha dimers.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hnf-1") (:form . "HNF-1") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DCoH") (:form . "DCoH") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 108)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 146)\n  (:start . 140) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 69))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 159)\n  (:start . 148) (:id . 70))\n ((:tag . "VBD") (:stem . "stabilize") (:form . "stabilized") (:end . 170)\n  (:start . 160) (:id . 71))\n ((:tag . "NN") (:stem . "hnf-1") (:form . "HNF-1") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 182)\n  (:start . 177) (:id . 73))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 189)\n  (:start . 183) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x91.4.1) (:span 117 120)))\n (:nscopes ((:id . :x91.4.1) (:span 117 132)))\n (:identifiers (:sid . :s91.4) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000830@unknown@formal@none@1@S@However, DCoH did not confer transcriptional activation to the GAL4 DNA binding domain.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "DCoH") (:form . "DCoH") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 44) (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GAL4") (:form . "GAL4") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x91.6.1) (:span 18 21)))\n (:nscopes ((:id . :x91.6.1) (:span 18 86)))\n (:identifiers (:sid . :s91.6) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000831@unknown@formal@none@1@S@These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DCoH") (:form . "DCoH") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 73) (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "JJ") (:stem . "tetrameric") (:form . "tetrameric") (:end . 91)\n  (:start . 81) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 101)\n  (:start . 92) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 141) (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 153)\n  (:start . 142) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 62))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 168)\n  (:start . 161) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x91.7.1) (:span 106 109)) ((:id . :x91.7.2) (:span 14 27)))\n (:hscopes ((:id . :x91.7.1) (:span 106 168))\n  ((:id . :x91.7.2) (:span 14 168)))\n (:identifiers (:sid . :s91.7) (:did . :|92108417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000832@unknown@formal@none@1@S@High affinity aldosterone binding to plasma membrane rich fractions from mononuclear leukocytes: is there a membrane receptor for mineralocorticoids?@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "rich") (:form . "rich") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 148) (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s92.1) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000833@unknown@formal@none@1@S@In vitro effects of aldosterone on the intracellular concentrations of sodium, potassium and calcium, cell volume and the sodium-proton-antiport have been described in intact human mononuclear leukocytes (HML).@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 67) (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "potassium") (:form . "potassium") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "volume") (:form . "volume") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "sodium-proton-antiport")\n  (:form . "sodium-proton-antiport") (:end . 144) (:start . 122) (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 164)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 174)\n  (:start . 168) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 192)\n  (:start . 181) (:id . 69))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 203)\n  (:start . 193) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 205) (:start . 204)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HML") (:form . "HML") (:end . 208) (:start . 205)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s92.2) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000834@unknown@formal@none@1@S@In the present paper, the binding of a [125I]-labeled aldosterone derivative to plasma membrane rich fractions of HML was studied.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "125I]-labeled") (:form . "125I]-labeled")\n  (:end . 53) (:start . 40) (:id . 52))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 65)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "rich") (:form . "rich") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HML") (:form . "HML") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s92.3) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000835@unknown@formal@none@1@S@High affinity binding of the radioligand with an apparent Kd of approximately 0.1 nM was found.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "radioligand") (:form . "radioligand") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "kd") (:form . "Kd") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x92.4.1) (:span 49 57)))\n (:hscopes ((:id . :x92.4.1) (:span 49 84)))\n (:identifiers (:sid . :s92.4) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000836@unknown@formal@none@1@S@Aldosterone displaced the tracer at a similar Kd.@(((:tag . "NNP") (:stem . "Aldosterone") (:form . "Aldosterone") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "displace") (:form . "displaced") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tracer") (:form . "tracer") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s92.5) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000837@unknown@formal@none@1@S@Both canrenone and cortisol were inactive as ligands up to concentrations of 0.1 microM.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "canrenone") (:form . "canrenone") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 73) (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s92.6) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000838@unknown@formal@none@1@S@The findings are the first to demonstrate membrane binding sites with a high affinity for aldosterone, but not for cortisol.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x92.7.1) (:span 107 110)))\n (:nscopes ((:id . :x92.7.1) (:span 107 123)))\n (:identifiers (:sid . :s92.7) (:did . :|92109743|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000840@unknown@formal@none@1@S@Transcription factor requirements for U2 snRNA-encoding gene activation in B lymphoid cells.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u2") (:form . "U2") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "snrna-encoding") (:form . "snRNA-encoding")\n  (:end . 55) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s93.1) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000841@unknown@formal@none@1@S@Transcription of a human U2 small nuclear RNA ( snRNA ) -encoding gene in HeLa cells requires a distal enhancer element, which is composed of one octamer motif (Oct) and three Sp 1-binding sites.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u2") (:form . "U2") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "snRNA") (:form . "snRNA") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "-encoding") (:form . "-encoding") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 153)\n  (:start . 146) (:id . 69))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 159)\n  (:start . 154) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 164) (:start . 161)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 74))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 175)\n  (:start . 170) (:id . 75))\n ((:tag . "NN") (:stem . "sp") (:form . "Sp") (:end . 178) (:start . 176)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "1-binding") (:form . "1-binding") (:end . 188)\n  (:start . 179) (:id . 77))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 194)\n  (:start . 189) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s93.2) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000842@unknown@formal@none@1@S@To study the transcription factor requirement in B-cells, different U2 enhancer constructions were transfected into the lymphoid cell line, BJA-B.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "u2") (:form . "U2") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "construction") (:form . "constructions")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BJA-B") (:form . "BJA-B") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s93.3) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000843@unknown@formal@none@1@S@The results showed that the activation of U2 snRNA transcription in B-cells also requires an enhancer comprising both the Oct and at least one Sp 1-binding site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "u2") (:form . "U2") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "snrna") (:form . "snRNA") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "VBG") (:stem . "comprise") (:form . "comprising") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Sp") (:form . "Sp") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "1-binding") (:form . "1-binding") (:end . 155)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s93.4) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000844@unknown@formal@none@1@S@Deletion of all the Sp 1-binding sites from the enhancer reduces transcription by 80-90% in HeLa, as well as in BJA-B cells, whereas the removal of the octamer-binding site reduces transcription to levels below detection in both cell types.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sp") (:form . "Sp") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "1-binding") (:form . "1-binding") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "CD") (:stem . "80-90") (:form . "80-90") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bja-b") (:form . "BJA-B") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 66))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 132)\n  (:start . 125) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 144)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 167) (:start . 152) (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 172) (:start . 168)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 180)\n  (:start . 173) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 194) (:start . 181) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 204)\n  (:start . 198) (:id . 77))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 210)\n  (:start . 205) (:id . 78))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 220)\n  (:start . 211) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 80))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 228) (:start . 224)\n  (:id . 81))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 233) (:start . 229)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 239)\n  (:start . 234) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s93.5) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000845@unknown@formal@none@1@S@Enhancers containing a single Oct have , nevertheless, the capacity to partially activate U2 snRNA transcription in both HeLa cells, in which only OTF-1 is expressed, and in BJA-B cells in which OTF-2 is the predominantly expressed octamer-binding factor.@(((:tag . "NNS") (:stem . "enhancer") (:form . "Enhancers") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "nevertheless") (:form . "nevertheless") (:end . 53)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "u2") (:form . "U2") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "snrna") (:form . "snRNA") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "bja-b") (:form . "BJA-B") (:end . 179)\n  (:start . 174) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 194)\n  (:start . 189) (:id . 76))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 200)\n  (:start . 195) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 203) (:start . 201)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 79))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 221) (:start . 208) (:id . 80))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 231)\n  (:start . 222) (:id . 81))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 247) (:start . 232) (:id . 82))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 254)\n  (:start . 248) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s93.6) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000846@unknown@formal@none@1@S@The most likely interpretation of our results is that both the ubiquitous transcription factor, OTF-1, and the B-cell-specific transcription factor, OTF-2, can activate U2 snRNA transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "OTF-1") (:form . "OTF-1") (:end . 101)\n  (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 126) (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "OTF-2") (:form . "OTF-2") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "u2") (:form . "U2") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "snrna") (:form . "snRNA") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x93.7.1) (:span 9 15)))\n (:hscopes ((:id . :x93.7.1) (:span 9 191)))\n (:identifiers (:sid . :s93.7) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000847@unknown@formal@none@1@S@The results also revealed a similar functional cooperation between the transcription factors which bind to the Oct and the adjacent Sp 1-binding site in BJA-B cells, as has been observed in HeLa cells, since a template which contains a weak binding site for OTFs expresses wild-type levels of U2 snRNA in both cell types when the weak octamer-binding site is combined with a Sp 1-binding site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . 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"wild-type") (:form . "wild-type") (:end . 282)\n  (:start . 273) (:id . 89))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 289)\n  (:start . 283) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 292) (:start . 290)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "U2") (:form . "U2") (:end . 295) (:start . 293)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "snRNA") (:form . "snRNA") (:end . 301)\n  (:start . 296) (:id . 93))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 304) (:start . 302)\n  (:id . 94))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 309) (:start . 305)\n  (:id . 95))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 314) (:start . 310)\n  (:id . 96))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 320)\n  (:start . 315) (:id . 97))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 325) (:start . 321)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 329) (:start . 326)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 334) (:start . 330)\n  (:id . 100))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 350) (:start . 335) (:id . 101))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 355) (:start . 351)\n  (:id . 102))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 358) (:start . 356)\n  (:id . 103))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 367)\n  (:start . 359) (:id . 104))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 372) (:start . 368)\n  (:id . 105))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 374) (:start . 373)\n  (:id . 106))\n ((:tag . "NNP") (:stem . "Sp") (:form . "Sp") (:end . 377) (:start . 375)\n  (:id . 107))\n ((:tag . "JJ") (:stem . "1-binding") (:form . "1-binding") (:end . 387)\n  (:start . 378) (:id . 108))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 392) (:start . 388)\n  (:id . 109))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 393) (:start . 392)\n  (:id . 110)))@@@1@69@((:identifiers (:sid . :s93.8) (:did . :|92112059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000848@unknown@formal@none@1@S@Cortisol receptor resistance: the variability of its clinical presentation and response to treatment.@(((:tag . "NNP") (:stem . "Cortisol") (:form . "Cortisol") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "variability") (:form . "variability") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s94.1) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000850@unknown@formal@none@1@S@Its occurrence is considered to be extremely rare.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s94.3) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000851@unknown@formal@none@1@S@In the present study we report on 6 patients (2 males and 4 females) with the syndrome.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 59) (:start . 58)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 67)\n  (:start . 60) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 59))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 86)\n  (:start . 78) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s94.4) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000852@unknown@formal@none@1@S@The first male patient presented with mild hypertension.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "present") (:form . "presented") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mild") (:form . "mild") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s94.5) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000853@unknown@formal@none@1@S@Hydrochlorothiazide therapy resulted in life-threatening hypokalemia.@(((:tag . "NNP") (:stem . "Hydrochlorothiazide")\n  (:form . "Hydrochlorothiazide") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 27)\n  (:start . 20) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 36)\n  (:start . 28) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "life-threatening") (:form . "life-threatening")\n  (:end . 56) (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "hypokalemia") (:form . "hypokalemia") (:end . 68)\n  (:start . 57) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s94.6) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000854@unknown@formal@none@1@S@The second male patient had slight hypertension without hypokalemia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "hypokalemia") (:form . "hypokalemia") (:end . 67)\n  (:start . 56) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 51)))@@@1@10@((:ncues ((:id . :x94.7.1) (:span 48 55)))\n (:nscopes ((:id . :x94.7.1) (:span 48 67)))\n (:identifiers (:sid . :s94.7) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000855@unknown@formal@none@1@S@All four female patients presented between the age of 20-30 yr with acne, hirsutism, and irregular menstruations.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "present") (:form . "presented") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "20-30") (:form . "20-30") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "yr") (:form . "yr") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "acne") (:form . "acne") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hirsutism") (:form . "hirsutism") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "irregular") (:form . "irregular") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "NNS") (:stem . "menstruation") (:form . "menstruations")\n  (:end . 112) (:start . 99) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s94.8) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000856@unknown@formal@none@1@S@Low dose dexamethasone therapy (1-1.5 mg/day) was of clinical benefit in these patients.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1-1.5") (:form . "1-1.5") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mg/day") (:form . "mg/day") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "benefit") (:form . "benefit") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s94.9) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000857@unknown@formal@none@1@S@All patients showed insufficient suppression of serum cortisol concentrations in the overnight 1-mg dexamethasone test.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 19) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 77) (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "overnight") (:form . "overnight") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "JJ") (:stem . "1-mg") (:form . "1-mg") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 113) (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 118) (:start . 114)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s94.10) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000858@unknown@formal@none@1@S@The diurnal rhythm of ACTH and cortisol was intact, albeit at an elevated level.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "diurnal") (:form . "diurnal") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "rhythm") (:form . "rhythm") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ACTH") (:form . "ACTH") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "albeit") (:form . "albeit") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s94.11) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000860@unknown@formal@none@1@S@Circulating adrenal androgen levels were increased in all patients.@(((:tag . "VBG") (:stem . "circulate") (:form . "Circulating") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s94.13) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000861@unknown@formal@none@1@S@Glucocorticoid receptors were investigated in a whole cell dexamethasone binding assay in mononuclear leukocytes.@(((:tag . "NNP") (:stem . "Glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 42)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s94.14) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000862@unknown@formal@none@1@S@In the first male patient, the number of receptors was very low, while the affinity was lower than that in controls.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 70) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 83)\n  (:start . 75) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 93) (:start . 88)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 115)\n  (:start . 107) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s94.15) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000863@unknown@formal@none@1@S@A lowered affinity to dexamethasone was found in one female patient, while a lowered number of receptors was found in three patients.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lowered") (:form . "lowered") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lowered") (:form . "lowered") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s94.16) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000864@unknown@formal@none@1@S@In the second male patient, no abnormalities were found.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 44)\n  (:start . 31) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x94.17.1) (:span 28 30)))\n (:nscopes ((:id . :x94.17.1) (:span 28 55)))\n (:identifiers (:sid . :s94.17) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000865@unknown@formal@none@1@S@As a bioassay for glucocorticoid action we also measured dexamethasone suppressibility of mitogen-stimulated incorporation of [3H]thymidine in mononuclear leukocytes.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bioassay") (:form . "bioassay") (:end . 13)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "suppressibility") (:form . "suppressibility")\n  (:end . 86) (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mitogen-stimulated") (:form . "mitogen-stimulated")\n  (:end . 108) (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 122) (:start . 109) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 127) (:start . 126)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "3H]thymidine") (:form . "3H]thymidine")\n  (:end . 139) (:start . 127) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 154)\n  (:start . 143) (:id . 60))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 165)\n  (:start . 155) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s94.18) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000866@unknown@formal@none@1@S@In the male patient with normal receptor status, dexamethasone suppressibility of [3H]thymidine incorporation was significantly lower than that in healthy controls with respect to both maximal suppression and IC50.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "suppressibility") (:form . "suppressibility")\n  (:end . 78) (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "3H]thymidine") (:form . "3H]thymidine") (:end . 95)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 109) (:start . 96) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 127) (:start . 114) (:id . 58))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 133) (:start . 128)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 163)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 176)\n  (:start . 169) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 192)\n  (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 204)\n  (:start . 193) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ic50") (:form . "IC50") (:end . 213) (:start . 209)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s94.19) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000867@unknown@formal@none@1@S@Partial cortisol receptor resistance might be less rare than previously thought.@(((:tag . "JJ") (:stem . "partial") (:form . "Partial") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x94.20.1) (:span 37 42)))\n (:hscopes ((:id . :x94.20.1) (:span 37 79)))\n (:identifiers (:sid . :s94.20) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000868@unknown@formal@none@1@S@In the six patients presented, at least three different forms can be recognized.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s94.21) (:did . :|92113075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000870@unknown@formal@none@1@S@Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.@(((:tag . "NNP") (:stem . "Kappa") (:form . "Kappa") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "b-specific") (:form . "B-specific") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 56) (:start . 42) (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s95.1) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000871@unknown@formal@none@1@S@Kappa B (kappa B) enhancer binding proteins isolated from the nuclei of activated human T cells produce two distinct nucleoprotein complexes when incubated with the kappa B element from the interleukin-2 receptor-alpha (IL-2R alpha) gene.@(((:tag . "NNP") (:stem . "Kappa") (:form . "Kappa") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "kappa") (:form . "kappa") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 26)\n  (:start . 18) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "nucleoprotein") (:form . "nucleoprotein")\n  (:end . 130) (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 170)\n  (:start . 165) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 203) (:start . 190) (:id . 74))\n ((:tag . "NN") (:stem . "receptor-alpha") (:form . "receptor-alpha")\n  (:end . 218) (:start . 204) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 231)\n  (:start . 226) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 237) (:start . 233)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s95.2) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000872@unknown@formal@none@1@S@These two DNA-protein complexes are composed of at least four host proteins (p50, p55, p75, p85), each of which shares structural similarity with the v-rel oncogene product.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p85") (:form . "p85") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 63))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 102) (:start . 98)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 66))\n ((:tag . "VBZ") (:stem . "share") (:form . "shares") (:end . 118)\n  (:start . 112) (:id . 67))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 129)\n  (:start . 119) (:id . 68))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 140)\n  (:start . 130) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 71))\n ((:tag . "NN") (:stem . "v-rel") (:form . "v-rel") (:end . 155)\n  (:start . 150) (:id . 72))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 164)\n  (:start . 156) (:id . 73))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 172)\n  (:start . 165) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s95.3) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000873@unknown@formal@none@1@S@Nuclear expression of these proteins is induced with distinctly biphasic kinetics following phorbol ester activation of T cells (p55/p75 early and p50/p85 late).@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "distinctly") (:form . "distinctly") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p55/p75") (:form . "p55/p75") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p50/p85") (:form . "p50/p85") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s95.4) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000874@unknown@formal@none@1@S@DNA-protein crosslinking studies have revealed that the more rapidly migrating B2 complex contains both p50 and p55 while the more slowly migrating B1 complex is composed of p50, p55, p75, and p85.@(((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "crosslinking") (:form . "crosslinking") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "VBG") (:stem . "migrate") (:form . "migrating") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "RB") (:stem . "slowly") (:form . "slowly") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "VBG") (:stem . "migrate") (:form . "migrating") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p85") (:form . "p85") (:end . 196) (:start . 193)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s95.5) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000875@unknown@formal@none@1@S@Site-directed mutagenesis of the wild-type IL-2R alpha kappa B enhancer (GGGGAATCTCCC) has revealed that the binding of p50 and p55 (B2 complex) is particularly sensitive to alteration of the 5' triplet of deoxyguanosine residues.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GGGGAATCTCCC") (:form . "GGGGAATCTCCC") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 160)\n  (:start . 148) (:id . 69))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 184)\n  (:start . 174) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 193) (:start . 192)\n  (:id . 75))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 194) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "triplet") (:form . "triplet") (:end . 202)\n  (:start . 195) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 78))\n ((:tag . "NN") (:stem . "deoxyguanosine") (:form . "deoxyguanosine")\n  (:end . 220) (:start . 206) (:id . 79))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s95.6) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000876@unknown@formal@none@1@S@In contrast, formation of the B1 complex, reflecting the binding of p75 and p85, critically depends upon the more 3' sequences of this enhancer element.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p85") (:form . "p85") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 91)\n  (:start . 81) (:id . 59))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 99)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 116) (:start . 115)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 126)\n  (:start . 117) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 134) (:start . 130)\n  (:id . 68))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 143)\n  (:start . 135) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 151)\n  (:start . 144) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s95.7) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000877@unknown@formal@none@1@S@DNA binding by all four of these Rel-related factors is blocked by selective chemical modification of lysine and arginine residues, suggesting that both of these basic amino acids are required for binding to the kappa B element.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "Rel-related") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "chemical") (:form . "chemical") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lysine") (:form . "lysine") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "arginine") (:form . "arginine") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 192)\n  (:start . 184) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 204)\n  (:start . 197) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 76))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 217)\n  (:start . 212) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 227)\n  (:start . 220) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x95.8.1) (:span 132 142)))\n (:hscopes ((:id . :x95.8.1) (:span 132 227)))\n (:identifiers (:sid . :s95.8) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000878@unknown@formal@none@1@S@Similarly, covalent modification of free sulfhydryl groups with diamide (reversible) or N-ethylmaleimide (irreversible) results in a complete loss of DNA binding activity.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "covalent") (:form . "covalent") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sulfhydryl") (:form . "sulfhydryl") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "diamide") (:form . "diamide") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "N-ethylmaleimide") (:form . "N-ethylmaleimide")\n  (:end . 104) (:start . 88) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 118)\n  (:start . 106) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s95.9) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000880@unknown@formal@none@1@S@These findings suggest that reduced cysteine thiols play an important role in the DNA binding activity of this family of Rel-related transcription factors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "thiol") (:form . "thiols") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "Rel-related") (:end . 132)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 146) (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x95.11.1) (:span 15 22)))\n (:hscopes ((:id . :x95.11.1) (:span 15 154)))\n (:identifiers (:sid . :s95.11) (:did . :|92118719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000881@unknown@formal@none@1@S@A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mitogen-inducible") (:form . "mitogen-inducible")\n  (:end . 25) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50/p105-nf-kappa") (:form . "p50/p105-NF-kappa")\n  (:end . 67) (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 82)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 101) (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 109)\n  (:start . 102) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 117)\n  (:start . 112) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s96.1) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000882@unknown@formal@none@1@S@A Rel-related, mitogen-inducible, kappa B-binding protein has been cloned as an immediate-early activation gene of human peripheral blood T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "Rel-related") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mitogen-inducible") (:form . "mitogen-inducible")\n  (:end . 32) (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 95) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s96.2) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000883@unknown@formal@none@1@S@The cDNA has an open reading frame of 900 amino acids capable of encoding a 97-kDa protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "CD") (:stem . "900") (:form . "900") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "97-kda") (:form . "97-kDa") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s96.3) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000884@unknown@formal@none@1@S@This protein is most similar to the 105-kDa precursor polypeptide of p50-NF-kappa B.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "105-kda") (:form . "105-kDa") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p50-nf-kappa") (:form . "p50-NF-kappa") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s96.4) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000885@unknown@formal@none@1@S@Like the 105-kDa precursor, it contains an amino-terminal Rel-related domain of about 300 amino acids and a carboxy-terminal domain containing six full cell cycle or ankyrin repeats.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "105-kda") (:form . "105-kDa") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 57) (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "Rel-related") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "300") (:form . "300") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 124) (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x96.5.1) (:span 163 165)))\n (:hscopes ((:id . :x96.5.1) (:span 143 181)))\n (:identifiers (:sid . :s96.5) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000886@unknown@formal@none@1@S@In vitro-translated proteins, truncated downstream of the Rel domain and excluding the repeats, bind kappa B sites.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "vitro-translated") (:form . "vitro-translated")\n  (:end . 19) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s96.6) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000887@unknown@formal@none@1@S@We refer to the kappa B-binding, truncated protein as p50B by analogy with p50-NF-kappa B and to the full-length protein as p97.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "refer") (:form . "refer") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "b-binding") (:form . "B-binding") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "p50B") (:form . "p50B") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "analogy") (:form . "analogy") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50-nf-kappa") (:form . "p50-NF-kappa") (:end . 87)\n  (:start . 75) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 112)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p97") (:form . "p97") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s96.7) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000888@unknown@formal@none@1@S@p50B is able to form heteromeric kappa B-binding complexes with RelB, as well as with p65 and p50, the two subunits of NF-kappa B.@(((:tag . "NNP") (:stem . "p50B") (:form . "p50B") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "heteromeric") (:form . "heteromeric") (:end . 32)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 115)\n  (:start . 107) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 127)\n  (:start . 119) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s96.8) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000890@unknown@formal@none@1@S@The data imply the existence of a complex family of NF-kappa B-like transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x96.10.1) (:span 9 14)))\n (:hscopes ((:id . :x96.10.1) (:span 9 89)))\n (:identifiers (:sid . :s96.10) (:did . :|92123193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000891@unknown@formal@none@1@S@[Changes in leucocytic estrogen receptor levels in patients with climacteric syndrome and therapeutic effect of liuwei dihuang pills]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 8)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "leucocytic") (:form . "leucocytic") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "climacteric") (:form . "climacteric") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "FW") (:stem . "liuwei") (:form . "liuwei") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . "FW") (:stem . "dihuang") (:form . "dihuang") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "pill") (:form . "pills") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s97.1) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000892@unknown@formal@none@1@S@The numbers of estrogen receptor (ER) in human peripheral leucocytes in 22 women with climacteric syndrome were measured by radioligand method.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "climacteric") (:form . "climacteric") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "radioligand") (:form . "radioligand") (:end . 135)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 142)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s97.2) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000893@unknown@formal@none@1@S@The results were compared with those of 12 normal child-bearing-age women.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "child-bearing-age") (:form . "child-bearing-age")\n  (:end . 67) (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s97.3) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000894@unknown@formal@none@1@S@It wat found that the contents of leucocytic ER in climacteric syndrome patients were significantly lower than normal child-bearing-age women.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "wat") (:form . "wat") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "content") (:form . "contents") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "leucocytic") (:form . "leucocytic") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "climacteric") (:form . "climacteric") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 99) (:start . 86) (:id . 56))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 105) (:start . 100)\n  (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "child-bearing-age") (:form . "child-bearing-age")\n  (:end . 135) (:start . 118) (:id . 60))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s97.4) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000895@unknown@formal@none@1@S@The authors used a Chinese prescription--Liuwei Dihuang Pills (LDP) to treat the patients for 2 months.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "chinese") (:form . "Chinese") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "prescription–Liuwei")\n  (:form . "prescription–Liuwei") (:end . 47) (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "Dihuang") (:form . "Dihuang") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "Pills") (:form . "Pills") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LDP") (:form . "LDP") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "treat") (:form . "treat") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s97.5) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000896@unknown@formal@none@1@S@The numbers of leucocytic ER were significantly increased after treatment.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "leucocytic") (:form . "leucocytic") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s97.6) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000897@unknown@formal@none@1@S@The data indicate that decrease of ER levels in cell may involve in the pathogenesis of climacteric syndrome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 84)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "climacteric") (:form . "climacteric") (:end . 99)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x97.7.1) (:span 53 56)) ((:id . :x97.7.2) (:span 9 22)))\n (:hscopes ((:id . :x97.7.1) (:span 53 108)) ((:id . :x97.7.2) (:span 9 108)))\n (:identifiers (:sid . :s97.7) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000898@unknown@formal@none@1@S@LDP not only increases plasma estradiol levels, but also increases the leucocytic ER levels.@(((:tag . "NNP") (:stem . "LDP") (:form . "LDP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "estradiol") (:form . "estradiol") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "leucocytic") (:form . "leucocytic") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s97.8) (:did . :|92127655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000900@unknown@formal@none@1@S@A novel primer extension method to detect the number of CAG repeats in the androgen receptor gene in families with X-linked spinal and bulbar muscular atrophy.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CAG") (:form . "CAG") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "x-linked") (:form . "X-linked") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "JJ") (:stem . "spinal") (:form . "spinal") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "bulbar") (:form . "bulbar") (:end . 141)\n  (:start . 135) (:id . 65))\n ((:tag . "JJ") (:stem . "muscular") (:form . "muscular") (:end . 150)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "atrophy") (:form . "atrophy") (:end . 158)\n  (:start . 151) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s98.1) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000901@unknown@formal@none@1@S@X-linked spinal and bulbar muscular atrophy (SBMA), an adult-onset form of motor neuron disease, was recently reported to be caused by amplification of the CAG repeats in the androgen receptor gene.@(((:tag . "JJ") (:stem . "x-linked") (:form . "X-linked") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "spinal") (:form . "spinal") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "bulbar") (:form . "bulbar") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "muscular") (:form . "muscular") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "atrophy") (:form . "atrophy") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SBMA") (:form . "SBMA") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "adult-onset") (:form . "adult-onset") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motor") (:form . "motor") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "neuron") (:form . "neuron") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 131)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "amplification") (:form . "amplification")\n  (:end . 148) (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CAG") (:form . "CAG") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 167)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 73))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 183)\n  (:start . 175) (:id . 74))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 192)\n  (:start . 184) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 197) (:start . 193)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s98.2) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000902@unknown@formal@none@1@S@We report here a simple and rapid strategy to detect the precise number of the CAGs.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cag") (:form . "CAGs") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s98.3) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000903@unknown@formal@none@1@S@After the DNA fragment containing the CAG repeats is amplified by the polymerase chain reaction, a primer extension is carried out;@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CAG") (:form . "CAG") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s98.4) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000904@unknown@formal@none@1@S@the extension of the end-labelled reverse primer adjacent to 3' end of CAG repeats stops at the first T after CAG repeats with the incorporation of dideoxy ATP in the reaction mixture.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "end-labelled") (:form . "end-labelled") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CAG") (:form . "CAG") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "VBZ") (:stem . "stop") (:form . "stops") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 101) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "NNP") (:stem . "CAG") (:form . "CAG") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 121)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 144) (:start . 131) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dideoxy") (:form . "dideoxy") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "atp") (:form . "ATP") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 175)\n  (:start . 167) (:id . 73))\n ((:tag . "NN") (:stem . "mixture") (:form . "mixture") (:end . 183)\n  (:start . 176) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s98.5) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000905@unknown@formal@none@1@S@The resultant primer products are analysed by denaturing polyacrylamide gel electrophoresis and autoradiography.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "resultant") (:form . "resultant") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "denature") (:form . "denaturing") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "polyacrylamide") (:form . "polyacrylamide")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 91) (:start . 76) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "autoradiography") (:form . "autoradiography")\n  (:end . 111) (:start . 96) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s98.6) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000906@unknown@formal@none@1@S@This method could be quite useful to detect not only CAG repeats in SBMA but also other polymorphic dinucleotide and trinucleotide repeats.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cag") (:form . "CAG") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SBMA") (:form . "SBMA") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "polymorphic") (:form . "polymorphic") (:end . 99)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "dinucleotide") (:form . "dinucleotide") (:end . 112)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "trinucleotide") (:form . "trinucleotide")\n  (:end . 130) (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x98.7.1) (:span 12 17)))\n (:hscopes ((:id . :x98.7.1) (:span 12 138)))\n (:identifiers (:sid . :s98.7) (:did . :|92134262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000907@unknown@formal@none@1@S@Activity of the kappa B enhancer of the interleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of NF-kappa B.@(((:tag . "NN") (:stem . "activity") (:form . "Activity") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 53) (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "somatic") (:form . "somatic") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 141)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s99.1) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000908@unknown@formal@none@1@S@The two nuclear proteins NF-kappa B (consisting of subunits p50 andp65) and the DNA-binding subunit of NF-kappa B (p50) by itself, also called KBF1, are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "andp65") (:form . "andp65") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 91)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 129)\n  (:start . 123) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 135) (:start . 131)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 142)\n  (:start . 136) (:id . 69))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 147) (:start . 143)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 152) (:start . 149)\n  (:id . 72))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 167) (:start . 153) (:id . 73))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 177)\n  (:start . 168) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 191)\n  (:start . 182) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 78))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 206)\n  (:start . 199) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 219)\n  (:start . 214) (:id . 82))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 226)\n  (:start . 220) (:id . 83))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 231) (:start . 227)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "IARC") (:form . "IARC") (:end . 236) (:start . 232)\n  (:id . 85))\n ((:tag . "CD") (:stem . "301.5") (:form . "301.5") (:end . 242)\n  (:start . 237) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s99.2) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000910@unknown@formal@none@1@S@Most hybrids express both KBF1 and NF-kappa B in their nuclei, but one hybrid expresses only KBF1.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "KBF1") (:form . "KBF1") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 54)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s99.4) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000911@unknown@formal@none@1@S@The kappa B enhancer of the gene encoding the interleukin-2 (IL-2) receptor alpha chain (IL-2R alpha) is functional only in the hybrids expressing nuclear NF-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 59) (:start . 46) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 115)\n  (:start . 105) (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 135)\n  (:start . 128) (:id . 67))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 146)\n  (:start . 136) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s99.5) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000912@unknown@formal@none@1@S@These findings show that nuclear NF-kappa B is necessary to activate the kappa B enhancer, while KBF1 by itself is not sufficient.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x99.6.1) (:span 115 118)))\n (:nscopes ((:id . :x99.6.1) (:span 115 129)))\n (:identifiers (:sid . :s99.6) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000913@unknown@formal@none@1@S@We propose that KBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and IL-2R alpha genes during the immune response.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 37)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "discuss") (:form . "discuss") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 124)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 153)\n  (:start . 148) (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 159)\n  (:start . 154) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 183)\n  (:start . 177) (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 192)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x99.7.1) (:span 92 95)))\n (:hscopes ((:id . :x99.7.1) (:span 78 192)))\n (:identifiers (:sid . :s99.7) (:did . :|92135145|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000914@unknown@formal@none@1@S@Influence of estradiol and tamoxifen on susceptibility of human breast cancer cell lines to lysis by lymphokine-activated killer cells.@(((:tag . "NN") (:stem . "influence") (:form . "Influence") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "estradiol") (:form . "estradiol") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tamoxifen") (:form . "tamoxifen") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 54) (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lymphokine-activated")\n  (:form . "lymphokine-activated") (:end . 121) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s100.1) (:did . :|92135176|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000915@unknown@formal@none@1@S@The design of combination hormonal and immunotherapeutic protocols for breast cancer patients may be facilitated by analysis of preclinical in vitro model systems.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "hormonal") (:form . "hormonal") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immunotherapeutic") (:form . "immunotherapeutic")\n  (:end . 56) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "protocol") (:form . "protocols") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 84)\n  (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "facilitate") (:form . "facilitated") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "preclinical") (:form . "preclinical") (:end . 139)\n  (:start . 128) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x100.2.1) (:span 94 97)))\n (:hscopes ((:id . :x100.2.1) (:span 0 162)))\n (:identifiers (:sid . :s100.2) (:did . :|92135176|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000916@unknown@formal@none@1@S@Estrogen receptor positive (ER+: MCF-7) and negative (ER-: MDA-MB-231) human breast cancer cell lines were utilized to evaluate the effects of tamoxifen (TAM) and estradiol (E2) on modulation of breast cancer target susceptibility to lysis by lymphokine-activated killer (LAK) cells.@(((:tag . "NNP") (:stem . "Estrogen") (:form . "Estrogen") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "er+") (:form . "ER+") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MCF-7") (:form . "MCF-7") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . 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5000917@unknown@formal@none@1@S@E2-stimulated ER+ cells were more susceptible to lysis by LAK cells than corresponding TAM-treated or control cells, while treatment of ER- cells with either E2 or TAM alone did not alter from control their susceptibility to this immune-mediated lysis.@(((:tag . "JJ") (:stem . "e2-stimulated") (:form . "E2-stimulated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "er+") (:form . "ER+") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 86)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "tam-treated") (:form . "TAM-treated") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "er-") (:form . "ER-") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . "NNP") (:stem . "E2") (:form . "E2") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TAM") (:form . "TAM") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 181) (:start . 178)\n  (:id . 72))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 187)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 200)\n  (:start . 193) (:id . 75))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 206)\n  (:start . 201) (:id . 76))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 221) (:start . 207) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 224) (:start . 222)\n  (:id . 78))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 229) (:start . 225)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "immune-mediated") (:form . "immune-mediated")\n  (:end . 245) (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 251)\n  (:start . 246) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x100.4.1) (:span 178 181)))\n (:nscopes ((:id . :x100.4.1) (:span 178 251)))\n (:identifiers (:sid . :s100.4) (:did . :|92135176|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000918@unknown@formal@none@1@S@All ER+ and ER- cells tested remained sensitive after treatment with TAM to lysis by LAK cells.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "er+") (:form . "ER+") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "er-") (:form . "ER-") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 28) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TAM") (:form . "TAM") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s100.5) (:did . :|92135176|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000920@unknown@formal@none@1@S@These in vitro results provide a preclinical rationale for in vivo testing of TAM, interleukin-2 (IL-2), and breast cancer reactive antibody-dependent cellular cytotoxicity facilitating antibody in patients with refractory or high risk breast cancer.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "preclinical") (:form . "preclinical") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "rationale") (:form . "rationale") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TAM") (:form . "TAM") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 96) (:start . 83) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 122)\n  (:start . 116) (:id . 64))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 131)\n  (:start . 123) (:id . 65))\n ((:tag . "JJ") (:stem . "antibody-dependent") (:form . "antibody-dependent")\n  (:end . 150) (:start . 132) (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 172)\n  (:start . 160) (:id . 68))\n ((:tag . "VBG") (:stem . "facilitate") (:form . "facilitating") (:end . 185)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 194)\n  (:start . 186) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 206)\n  (:start . 198) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 211) (:start . 207)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "refractory") (:form . "refractory") (:end . 222)\n  (:start . 212) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 225) (:start . 223)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 230) (:start . 226)\n  (:id . 76))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 235) (:start . 231)\n  (:id . 77))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 242)\n  (:start . 236) (:id . 78))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 249)\n  (:start . 243) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s100.7) (:did . :|92135176|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000921@unknown@formal@none@1@S@Glucocorticoid receptor and inhibition of 3-O-methyl-D-glucose uptake by glucocorticoids in peripheral blood leukocytes from normal humans: correlation between receptor level and hormone effect in vitro.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "3-O-methyl-D-glucose")\n  (:form . "3-O-methyl-D-glucose") (:end . 62) (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 69)\n  (:start . 63) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 88) (:start . 73) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 102)\n  (:start . 92) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 108)\n  (:start . 103) (:id . 53))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 119)\n  (:start . 109) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 124) (:start . 120)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 131)\n  (:start . 125) (:id . 56))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 138)\n  (:start . 132) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 139) (:start . 138)\n  (:id . 58))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 151)\n  (:start . 140) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 159)\n  (:start . 152) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 168)\n  (:start . 160) (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 174)\n  (:start . 169) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 186)\n  (:start . 179) (:id . 64))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 193)\n  (:start . 187) (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 202)\n  (:start . 197) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s101.1) (:did . :|92142646|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000922@unknown@formal@none@1@S@We have measured the glucocorticoid receptor concentration in mononuclear and polymorphonuclear leukocytes, both of which were isolated from peripheral blood from ten healthy male volunteers.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 35) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 58) (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 95) (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 106)\n  (:start . 96) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 135)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 151)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 157)\n  (:start . 152) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 162) (:start . 158)\n  (:id . 63))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 174)\n  (:start . 167) (:id . 65))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 190)\n  (:start . 180) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s101.2) (:did . :|92142646|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000923@unknown@formal@none@1@S@In parallel, the inhibitory effect of dexamethasone on 3-O-methyl-D-glucose uptake was assayed in the corresponding mononuclear leukocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "3-O-methyl-D-glucose")\n  (:form . "3-O-methyl-D-glucose") (:end . 75) (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 115)\n  (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 127)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s101.3) (:did . :|92142646|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000924@unknown@formal@none@1@S@The glucocorticoid receptor levels in mononuclear leukocytes correlated with those in polymorphonuclear leukocytes, and there was a linear relationship between the cellular glucocorticoid receptor levels and glucocorticoid-mediated inhibition of the uptake of 3-O-methyl-D-glucose in mononuclear leukocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 103) (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 114)\n  (:start . 104) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 125)\n  (:start . 120) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 129) (:start . 126)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 138)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 151)\n  (:start . 139) (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 159)\n  (:start . 152) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 172)\n  (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 187) (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 196)\n  (:start . 188) (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 203)\n  (:start . 197) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "glucocorticoid-mediated") (:end . 231) (:start . 208) (:id . 69))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 242)\n  (:start . 232) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 72))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 256)\n  (:start . 250) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 259) (:start . 257)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "3-O-methyl-D-glucose")\n  (:form . "3-O-methyl-D-glucose") (:end . 280) (:start . 260) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 283) (:start . 281)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 295)\n  (:start . 284) (:id . 77))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 306)\n  (:start . 296) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s101.4) (:did . :|92142646|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000925@unknown@formal@none@1@S@When mononuclear leukocytes were incubated in the presence of 8-bromo-cAMP, cellular glucocorticoid receptor levels increased and a more pronounced inhibitory effect of dexamethasone was observed on the transport of 3-O-methyl-D-glucose.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "8-bromo-cAMP") (:form . "8-bromo-cAMP") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 99) (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 108)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 158)\n  (:start . 148) (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 165)\n  (:start . 159) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 182) (:start . 169) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 186) (:start . 183)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 195)\n  (:start . 187) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 198) (:start . 196)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transport") (:form . "transport") (:end . 212)\n  (:start . 203) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "3-O-methyl-D-glucose")\n  (:form . "3-O-methyl-D-glucose") (:end . 236) (:start . 216) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s101.5) (:did . :|92142646|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000926@unknown@formal@none@1@S@We conclude that the cellular glucocorticoid receptor levels in peripheral blood leukocytes reflect in vitro responsiveness to glucocorticoids in mononuclear leukocytes from healthy males, and that the individual responsiveness may alter upon changes in the cellular levels of glucocorticoid receptor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "VBP") (:stem . "reflect") (:form . "reflect") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 123) (:start . 109) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 142) (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 157)\n  (:start . 146) (:id . 61))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 168)\n  (:start . 158) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 173) (:start . 169)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 181)\n  (:start . 174) (:id . 64))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 187)\n  (:start . 182) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 197) (:start . 193)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 212)\n  (:start . 202) (:id . 70))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 227) (:start . 213) (:id . 71))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 231) (:start . 228)\n  (:id . 72))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 237)\n  (:start . 232) (:id . 73))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 242) (:start . 238)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 250)\n  (:start . 243) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 253) (:start . 251)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 257) (:start . 254)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 266)\n  (:start . 258) (:id . 78))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 273)\n  (:start . 267) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 276) (:start . 274)\n  (:id . 80))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 291) (:start . 277) (:id . 81))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 300)\n  (:start . 292) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x101.6.1) (:span 228 231)))\n (:hscopes ((:id . :x101.6.1) (:span 228 300)))\n (:identifiers (:sid . :s101.6) (:did . :|92142646|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000927@unknown@formal@none@1@S@Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "th") (:form . "TH") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s102.1) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000928@unknown@formal@none@1@S@The human interferon beta (IFN-beta) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "enhanson") (:form . "enhanson") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 186)\n  (:start . 178) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s102.2) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000930@unknown@formal@none@1@S@From HeLa cells, two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity, whereas from T-cells, four proteins--a major protein of 52 kD and three minor proteins of 82 , 67 , and 43-47 kD--were purified.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "kilodalton") (:form . "kilodaltons") (:end . 60)\n  (:start . 49) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "copurifie") (:form . "copurified") (:end . 76)\n  (:start . 66) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 111)\n  (:start . 104) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 124)\n  (:start . 117) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 130) (:start . 126)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proteins–a") (:form . "proteins–a") (:end . 142)\n  (:start . 131) (:id . 68))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 148)\n  (:start . 143) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 162) (:start . 160)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 165) (:start . 163)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 74))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 175)\n  (:start . 170) (:id . 75))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 181)\n  (:start . 176) (:id . 76))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 190)\n  (:start . 182) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 78))\n ((:tag . "CD") (:stem . "82") (:form . "82") (:end . 196) (:start . 194)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 80))\n ((:tag . "CD") (:stem . "67") (:form . "67") (:end . 201) (:start . 199)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 83))\n ((:tag . "CD") (:stem . "43-47") (:form . "43-47") (:end . 213)\n  (:start . 208) (:id . 84))\n ((:tag . "NN") (:stem . "kD–were") (:form . "kD–were") (:end . 222)\n  (:start . 214) (:id . 85))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 231)\n  (:start . 223) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s102.4) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000931@unknown@formal@none@1@S@Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA ) 4 tetrahexamer sequence and the PRDI domain.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 18)\n  (:start . 9) (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "AAGTGA") (:form . "AAGTGA") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tetrahexamer") (:form . "tetrahexamer") (:end . 127)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PRDI") (:form . "PRDI") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 156)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s102.5) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000932@unknown@formal@none@1@S@This protein is immunologically distinct from IRF-1/ISGF2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 31) (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "irf-1/isgf2") (:form . "IRF-1/ISGF2") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s102.6) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000933@unknown@formal@none@1@S@Uninduced or Sendai virus induced HeLa extracts were used to examine transcription in vitro using a series of IFN beta promoter deletions.@(((:tag . "NNP") (:stem . "Uninduced") (:form . "Uninduced") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Sendai") (:form . "Sendai") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s102.7) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000934@unknown@formal@none@1@S@Deletions upstream of the PRDII element increased transcription in the uninduced extract, indicating predominantly negative regulation of the promoter.@(((:tag . "NNS") (:stem . "deletion") (:form . "Deletions") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PRDII") (:form . "PRDII") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 134)\n  (:start . 124) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 150)\n  (:start . 142) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x102.8.1) (:span 90 100)))\n (:hscopes ((:id . :x102.8.1) (:span 90 150)))\n (:identifiers (:sid . :s102.8) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000935@unknown@formal@none@1@S@A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts, and deletion of PRDI and PRDII elements decreased this induced level of transcription.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "2-4-fold") (:form . "2-4-fold") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Sendai") (:form . "Sendai") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PRDI") (:form . "PRDI") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PRDII") (:form . "PRDII") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 187) (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s102.9) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000936@unknown@formal@none@1@S@When purified PRDII and tetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "PRDII") (:form . "PRDII") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tetrahexamer") (:form . "tetrahexamer") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "4-fold") (:form . "4-fold") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 123) (:start . 110) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s102.10) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000937@unknown@formal@none@1@S@These experiments demonstrate that it is possible to modulate IFN-beta transcription in vitro but indicate that additional proteins may be required to fully activate IFN-beta transcription.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 156)\n  (:start . 151) (:id . 64))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 188) (:start . 175) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x102.11.1) (:span 132 135))\n  ((:id . :x102.11.2) (:span 98 111)) ((:id . :x102.11.3) (:span 41 49)))\n (:hscopes ((:id . :x102.11.1) (:span 112 188))\n  ((:id . :x102.11.2) (:span 98 188)) ((:id . :x102.11.3) (:span 35 93)))\n (:identifiers (:sid . :s102.11) (:did . :|92144438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000938@unknown@formal@none@1@S@Structure function analysis of vitamin D analogs with C-ring modifications.@(((:tag . "NN") (:stem . "structure") (:form . "Structure") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-ring") (:form . "C-ring") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s103.1) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000940@unknown@formal@none@1@S@Small apolar substitutions (11 alpha-methyl, 11 alpha-fluoromethyl) did not markedly decrease the affinity for the vitamin D receptor, but larger (11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl) or more polar substitutions (11 alpha-hydroxymethyl, 11 alpha-(2-hydroxyethyl] decreased the affinity to less than 5% of that of 1 alpha,25-OH)2D3.@(((:tag . "JJ") (:stem . "small") (:form . "Small") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "apolar") (:form . "apolar") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha-methyl") (:form . "alpha-methyl") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . 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5000941@unknown@formal@none@1@S@Their affinity for the vitamin D-binding protein, however, increased up to 4-fold.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "d-binding") (:form . "D-binding") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "4-fold") (:form . "4-fold") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s103.4) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000942@unknown@formal@none@1@S@The biological activity of 11 alpha-methyl-1 alpha,25-(OH)2D3 closely resembled that of the natural hormone on normal and leukemic cell proliferation and bone resorption, whereas its in vivo effect on calcium metabolism of the rachitic chick was about 50% of that of 1 alpha,25-(OH)2D3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha-methyl-1") (:form . "alpha-methyl-1")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 61) (:start . 45) (:id . 48))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 69)\n  (:start . 62) (:id . 49))\n ((:tag . "VBD") (:stem . "resemble") (:form . "resembled") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 149) (:start . 136) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 158) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "resorption") (:form . "resorption") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 178)\n  (:start . 171) (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 68))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 190) (:start . 186)\n  (:id . 69))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 197)\n  (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 208)\n  (:start . 201) (:id . 72))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 219)\n  (:start . 209) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "rachitic") (:form . "rachitic") (:end . 235)\n  (:start . 227) (:id . 76))\n ((:tag . "NN") (:stem . "chick") (:form . "chick") (:end . 241)\n  (:start . 236) (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 245) (:start . 242)\n  (:id . 78))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 251)\n  (:start . 246) (:id . 79))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 254) (:start . 252)\n  (:id . 80))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 255) (:start . 254)\n  (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 258) (:start . 256)\n  (:id . 82))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 263) (:start . 259)\n  (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 266) (:start . 264)\n  (:id . 84))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 268) (:start . 267)\n  (:id . 85))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 285) (:start . 269) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s103.5) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000943@unknown@formal@none@1@S@The 11 beta-methyl analog had a greater than 10-fold lower activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "beta-methyl") (:form . "beta-methyl") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "analog") (:form . "analog") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s103.6) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000944@unknown@formal@none@1@S@The differentiating effects of the other C-11 analogs on human promyeloid leukemia cells (HL-60) agreed well with their bone-resorbing activity and receptor affinity, but they demonstrated lower calcemic effects in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-11") (:form . "C-11") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "promyeloid") (:form . "promyeloid") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "agree") (:form . "agreed") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "bone-resorbing") (:form . "bone-resorbing")\n  (:end . 134) (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 188)\n  (:start . 176) (:id . 70))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 194) (:start . 189)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "calcemic") (:form . "calcemic") (:end . 203)\n  (:start . 195) (:id . 72))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 211)\n  (:start . 204) (:id . 73))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 74))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 219) (:start . 215)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s103.7) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000945@unknown@formal@none@1@S@Large or polar substitutions on C-11 of 1 alpha,25-(OH)2D3 thus impair the binding of the vitamin D receptor but increase the affinity to vitamin D-binding protein.@(((:tag . "JJ") (:stem . "large") (:form . "Large") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "polar") (:form . "polar") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-11") (:form . "C-11") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 58) (:start . 42) (:id . 50))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "impair") (:form . "impair") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 145)\n  (:start . 138) (:id . 65))\n ((:tag . "JJ") (:stem . "d-binding") (:form . "D-binding") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s103.8) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000946@unknown@formal@none@1@S@The effects of many C-11-substituted 1 alpha,25-(OH)2D3 analogs on HL-60 cell differentiation exceeded their activity on calcium metabolism.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "c-11-substituted") (:form . "C-11-substituted")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 55) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 93) (:start . 78) (:id . 53))\n ((:tag . "VBD") (:stem . "exceed") (:form . "exceeded") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 108)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 139)\n  (:start . 129) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s103.9) (:did . :|92147648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000947@unknown@formal@none@1@S@Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular model.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 33)\n  (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 40)\n  (:start . 34) (:id . 45))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 52)\n  (:start . 41) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s104.1) (:did . :|92153263|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000948@unknown@formal@none@1@S@The regulation of gene expression during lymphocyte differentiation is a complex process involving interactions between multiple positive and negative transcriptional regulatory elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 111)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 119)\n  (:start . 112) (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 128)\n  (:start . 120) (:id . 57))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 137)\n  (:start . 129) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 150)\n  (:start . 142) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 166) (:start . 151) (:id . 61))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 177)\n  (:start . 167) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 186)\n  (:start . 178) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s104.2) (:did . :|92153263|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000950@unknown@formal@none@1@S@Major recent developments, including the identification of novel families of transcription factors that regulate multiple T-cell genes during thymocyte ontogeny and T-cell activation, are described.@(((:tag . "JJ") (:stem . "major") (:form . "Major") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "development") (:form . "developments") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 55) (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 128)\n  (:start . 122) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "ontogeny") (:form . "ontogeny") (:end . 160)\n  (:start . 152) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 171)\n  (:start . 165) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 182)\n  (:start . 172) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 187) (:start . 184)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 197)\n  (:start . 188) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s104.4) (:did . :|92153263|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000951@unknown@formal@none@1@S@Cortisol resistance in acquired immunodeficiency syndrome.@(((:tag . "NNP") (:stem . "Cortisol") (:form . "Cortisol") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 48) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 57)\n  (:start . 49) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s105.1) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000952@unknown@formal@none@1@S@This study concerns 9 iv drug abusers with acquired immunodeficiency syndrome (AIDS) who developed hypercortisolism without the clinical signs or metabolic consequences of hypercortisolism.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "concern") (:form . "concerns") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "iv") (:form . "iv") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "abuser") (:form . "abusers") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 68) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "hypercortisolism") (:form . "hypercortisolism")\n  (:end . 115) (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "NNS") (:stem . "sign") (:form . "signs") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 168)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hypercortisolism") (:form . "hypercortisolism")\n  (:end . 188) (:start . 172) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x105.2.1) (:span 116 123)))\n (:nscopes ((:id . :x105.2.1) (:span 116 188)))\n (:identifiers (:sid . :s105.2) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000953@unknown@formal@none@1@S@All patients were characterized by an Addisonian picture (weakness, weight loss, hypotension, hyponatremia, and intense mucocutaneous melanosis).@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "addisonian") (:form . "Addisonian") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "picture") (:form . "picture") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "weakness") (:form . "weakness") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hypotension") (:form . "hypotension") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hyponatremia") (:form . "hyponatremia") (:end . 106)\n  (:start . 94) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intense") (:form . "intense") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "mucocutaneous") (:form . "mucocutaneous")\n  (:end . 133) (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "melanosis") (:form . "melanosis") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s105.3) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000954@unknown@formal@none@1@S@An acquired form of peripheral resistance to glucocorticoids was suspected.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "suspect") (:form . "suspected") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x105.4.1) (:span 65 74)))\n (:hscopes ((:id . :x105.4.1) (:span 0 74)))\n (:identifiers (:sid . :s105.4) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000955@unknown@formal@none@1@S@We, therefore, examined glucocorticoid receptor characteristics on mononuclear leukocytes by measuring [3H]dexamethasone binding and the effect of dexamethasone on [3H]thymidine incorporation, which is one of the effects of glucocorticoid receptor activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 13)\n  (:start . 4) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 38) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 63) (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "measure") (:form . "measuring") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "3H]dexamethasone") (:form . "3H]dexamethasone")\n  (:end . 120) (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 143)\n  (:start . 137) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 160) (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 163) (:start . 161)\n  (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "3H]thymidine") (:form . "3H]thymidine")\n  (:end . 177) (:start . 165) (:id . 65))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 191) (:start . 178) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 198)\n  (:start . 193) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 201) (:start . 199)\n  (:id . 69))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 205) (:start . 202)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 220)\n  (:start . 213) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 74))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 238) (:start . 224) (:id . 75))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 247)\n  (:start . 239) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 258)\n  (:start . 248) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s105.5) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000956@unknown@formal@none@1@S@Glucocorticoid receptor density was increased in AIDS patients with an Addisonian picture (group 1; 16.2 ± 9.4 fmol/million cells) compared to values in 12 AIDS patients without an Addisonian picture (group 2; 6.05 ± 2.6 fmol/million cells; P less than 0.01) and sex- and age-matched controls (3.15 ± 2.3 fmol/million cells; P less than 0.01).@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NNP") (:stem . 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5000957@unknown@formal@none@1@S@The affinity of glucocorticoid receptors (Kd) was strikingly decreased (9.36 ± 3.44 nM in group 1; 3.2 ± 1.5 nM in group 2; 2.0 ± 0.8 nM in controls; P less than 0.01).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "RB") (:stem . "strikingly") (:form . "strikingly") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "9.36") (:form . "9.36") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "CD") (:stem . "3.44") (:form . "3.44") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "CD") (:stem . "3.2") (:form . "3.2") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 104) (:start . 103)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1.5") (:form . "1.5") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 111) (:start . 109)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 66))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 120)\n  (:start . 115) (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 122) (:start . 121)\n  (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 123) (:start . 122)\n  (:id . 69))\n ((:tag . "CD") (:stem . "2.0") (:form . "2.0") (:end . 127) (:start . 124)\n  (:id . 70))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 129) (:start . 128)\n  (:id . 71))\n ((:tag . "CD") (:stem . "0.8") (:form . "0.8") (:end . 133) (:start . 130)\n  (:id . 72))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 136) (:start . 134)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 148)\n  (:start . 140) (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 149) (:start . 148)\n  (:id . 76))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 151) (:start . 150)\n  (:id . 77))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 156) (:start . 152)\n  (:id . 78))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 161) (:start . 157)\n  (:id . 79))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 166) (:start . 162)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s105.7) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000958@unknown@formal@none@1@S@[3H]Thymidine incorporation was decreased dose-dependently by dexamethasone in controls and patients;@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "3H]Thymidine") (:form . "3H]Thymidine") (:end . 13)\n  (:start . 1) (:id . 43))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 58) (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 75) (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 100)\n  (:start . 92) (:id . 53))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 101) (:start . 100)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s105.8) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000960@unknown@formal@none@1@S@In conclusion, AIDS patients with hypercortisolism and clinical features of peripheral resistance to glucocorticoids are characterized by abnormal glucocorticoid receptors on lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypercortisolism") (:form . "hypercortisolism")\n  (:end . 50) (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 116) (:start . 101) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 134) (:start . 121) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 146)\n  (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 161) (:start . 147) (:id . 61))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 171)\n  (:start . 162) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 174) (:start . 172)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 186)\n  (:start . 175) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s105.10) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000961@unknown@formal@none@1@S@Resistance to glucocorticoids implies a complex change in immune-endocrine function, which may be important in the course of immunodeficiency syndrome.@(((:tag . "NN") (:stem . "resistance") (:form . "Resistance") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune-endocrine") (:form . "immune-endocrine")\n  (:end . 74) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 141) (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 150)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x105.11.1) (:span 91 94))\n  ((:id . :x105.11.2) (:span 30 37)))\n (:hscopes ((:id . :x105.11.1) (:span 91 150))\n  ((:id . :x105.11.2) (:span 30 150)))\n (:identifiers (:sid . :s105.11) (:did . :|92156261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000962@unknown@formal@none@1@S@Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 38) (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 58)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 95) (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 101) (:start . 96)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 103) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "myelomonoblastic") (:form . "myelomonoblastic")\n  (:end . 133) (:start . 117) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s106.1) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000963@unknown@formal@none@1@S@The effects of human immunodeficiency virus 1 (HIV-1) infection on cellular differentiation and NF-kappa B DNA binding activity have been investigated in a new model of myeloid differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 37) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 91) (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 150)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 176)\n  (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 192) (:start . 177) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s106.2) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000964@unknown@formal@none@1@S@PLB-985 cells represent a bipotential myelomonoblastic cell population capable of either granulocytic or monocytic differentiation after induction with appropriate inducers.@(((:tag . "NNP") (:stem . "PLB-985") (:form . "PLB-985") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "bipotential") (:form . "bipotential") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "myelomonoblastic") (:form . "myelomonoblastic")\n  (:end . 54) (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 101)\n  (:start . 89) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 114)\n  (:start . 105) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 130) (:start . 115) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 136)\n  (:start . 131) (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 146)\n  (:start . 137) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 163)\n  (:start . 152) (:id . 60))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 172)\n  (:start . 164) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s106.3) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000965@unknown@formal@none@1@S@By virtue of the presence of CD4 on the cell surface, PLB-985 cells were chronically infected with HIV-1 strain IIIB.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "virtue") (:form . "virtue") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 52)\n  (:start . 45) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PLB-985") (:form . "PLB-985") (:end . 61)\n  (:start . 54) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 84)\n  (:start . 73) (:id . 57))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 104)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "NNP") (:stem . "IIIB") (:form . "IIIB") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s106.4) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000966@unknown@formal@none@1@S@PLB-IIIB cells clearly possessed a more monocytic phenotype than the parental myeloblasts, as determined by differential staining, increased expression of the myeloid-specific surface markers, and transcription of the c-fms proto-oncogene.@(((:tag . "NNP") (:stem . "PLB-IIIB") (:form . "PLB-IIIB") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "possess") (:form . "possessed") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "myeloblast") (:form . "myeloblasts") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 120)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 175) (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 183)\n  (:start . 176) (:id . 66))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 191)\n  (:start . 184) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 210) (:start . 197) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 72))\n ((:tag . "NN") (:stem . "c-fms") (:form . "c-fms") (:end . 223)\n  (:start . 218) (:id . 73))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 238) (:start . 224) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s106.5) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000967@unknown@formal@none@1@S@NF-kappa B binding activity was inducible by tumor necrosis factor and phorbol myristate acetate in PLB-985.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PLB-985") (:form . "PLB-985") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s106.6) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000968@unknown@formal@none@1@S@However, in PLB-IIIB cells, constitutive expression of a novel NF-kappa B complex was detected, composed of proteins ranging between 70 and 110 kD.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PLB-IIIB") (:form . "PLB-IIIB") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "CD") (:stem . "110") (:form . "110") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s106.7) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000970@unknown@formal@none@1@S@Mutations affecting the 5' guanine residues of the kappa B site were unable to compete for these NF-kappa B-related proteins.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 115)\n  (:start . 106) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x106.9.1) (:span 69 75)))\n (:nscopes ((:id . :x106.9.1) (:span 69 124)))\n (:identifiers (:sid . :s106.9) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000971@unknown@formal@none@1@S@Inducibility of endogenous IFN-beta and IFN-alpha RNA was also increased in PLB-IIIB cells.@(((:tag . "NN") (:stem . "inducibility") (:form . "Inducibility") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PLB-IIIB") (:form . "PLB-IIIB") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s106.10) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000972@unknown@formal@none@1@S@These studies indicate that HIV-1 infection of myelomonoblastic cells may select for a more mature monocytic phenotype and that unique subunit associations of NF-kappa B DNA binding proteins may contribute to differential NF-kappa B-mediated gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myelomonoblastic") (:form . "myelomonoblastic")\n  (:end . 63) (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VB") (:stem . "select") (:form . "select") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "association") (:form . "associations") (:end . 155)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 167)\n  (:start . 159) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 190)\n  (:start . 182) (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 205)\n  (:start . 195) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 221)\n  (:start . 209) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 230)\n  (:start . 222) (:id . 74))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 241)\n  (:start . 231) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 246) (:start . 242)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 257)\n  (:start . 247) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x106.11.1) (:span 191 194))\n  ((:id . :x106.11.2) (:span 70 73)) ((:id . :x106.11.3) (:span 14 27)))\n (:hscopes ((:id . :x106.11.1) (:span 191 257))\n  ((:id . :x106.11.2) (:span 70 118)) ((:id . :x106.11.3) (:span 14 257)))\n (:identifiers (:sid . :s106.11) (:did . :|92156797|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000973@unknown@formal@none@1@S@The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-150") (:form . "-150") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 53) (:start . 49)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 64)\n  (:start . 58) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 58))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 77)\n  (:start . 68) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 87) (:start . 82)\n  (:id . 61))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 94)\n  (:start . 88) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 112)\n  (:start . 106) (:id . 65))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 114) (:start . 113)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 133)\n  (:start . 122) (:id . 69))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 135) (:start . 134)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 144)\n  (:start . 136) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x107.1.2) (:span 58 64)))\n (:ncues ((:id . :x107.1.1) (:span 30 33)))\n (:hscopes ((:id . :x107.1.2) (:span 0 144)))\n (:nscopes ((:id . :x107.1.1) (:span 30 53)))\n (:identifiers (:sid . :s107.1) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000974@unknown@formal@none@1@S@Stimulation of T cells with antigen results in activation of several kinases, including protein kinase C (PKC), that may mediate the later induction of activation-related genes.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 148)\n  (:start . 139) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "activation-related") (:form . "activation-related")\n  (:end . 170) (:start . 152) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x107.2.1) (:span 117 120)))\n (:hscopes ((:id . :x107.2.1) (:span 117 176)))\n (:identifiers (:sid . :s107.2) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000975@unknown@formal@none@1@S@We have examined the potential role of PKC in induction of the interleukin 2 (IL-2) gene in T cells stimulated through the T cell receptor/CD3 complex.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 110)\n  (:start . 100) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 118)\n  (:start . 111) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "receptor/cd3") (:form . "receptor/CD3") (:end . 142)\n  (:start . 130) (:id . 68))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 150)\n  (:start . 143) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s107.3) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000976@unknown@formal@none@1@S@We have previously shown that prolonged treatment of the untransformed T cell clone Ar-5 with phorbol esters results in downmodulation of the alpha and beta isozymes of PKC, and abrogates induction of IL-2 mRNA and protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "untransformed") (:form . "untransformed")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ar-5") (:form . "Ar-5") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "downmodulation") (:form . "downmodulation")\n  (:end . 134) (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "isozyme") (:form . "isozymes") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "abrogate") (:form . "abrogates") (:end . 187)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 210) (:start . 206)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 222)\n  (:start . 215) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s107.4) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000977@unknown@formal@none@1@S@Here we show that phorbol ester treatment also abolishes induction of chloramphenicol acetyltransferase activity in Ar-5 cells transfected with a plasmid containing the IL-2 promoter linked to this reporter gene.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 85) (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 103) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 112)\n  (:start . 104) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ar-5") (:form . "Ar-5") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 153)\n  (:start . 146) (:id . 62))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 164)\n  (:start . 154) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 173) (:start . 169)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 182)\n  (:start . 174) (:id . 66))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 189)\n  (:start . 183) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 192) (:start . 190)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 197) (:start . 193)\n  (:id . 69))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 206)\n  (:start . 198) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 211) (:start . 207)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s107.5) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000978@unknown@formal@none@1@S@The IL-2 promoter contains binding sites for nuclear factors including NFAT-1, Oct, NF-kappa B, and AP-1, which are all potentially sensitive to activation of PKC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "RB") (:stem . "all") (:form . "all") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 131)\n  (:start . 120) (:id . 65))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x107.6.1) (:span 120 131)))\n (:hscopes ((:id . :x107.6.1) (:span 120 162)))\n (:identifiers (:sid . :s107.6) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000980@unknown@formal@none@1@S@In contrast, mutations in the AP-1 site located at -150 bp almost completely abrogate induction of the IL-2 promoter, and appearance of an inducible nuclear factor binding to this site is sensitive to PKC depletion.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-150") (:form . "-150") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "VBP") (:stem . "abrogate") (:form . "abrogate") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 69))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 184) (:start . 180)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 187) (:start . 185)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 197)\n  (:start . 188) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 204) (:start . 201)\n  (:id . 77))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 214)\n  (:start . 205) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s107.8) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000981@unknown@formal@none@1@S@Moreover, cotransfections with c-fos and c-jun expression plasmids markedly enhance induction of the IL-2 promoter in minimally stimulated T cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "cotransfection") (:form . "cotransfections")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "RB") (:stem . "minimally") (:form . "minimally") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s107.9) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000982@unknown@formal@none@1@S@Our results indicate that the AP-1 site at -150 bp represents a major, if not the only, site of PKC responsiveness in the IL-2 promoter.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-150") (:form . "-150") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 86) (:start . 82)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 92) (:start . 88)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 99) (:start . 96)\n  (:id . 63))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 114) (:start . 100) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 126) (:start . 122)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 135)\n  (:start . 127) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x107.10.1) (:span 71 77))\n  ((:id . :x107.10.2) (:span 12 25)))\n (:hscopes ((:id . :x107.10.1) (:span 71 86))\n  ((:id . :x107.10.2) (:span 12 135)))\n (:identifiers (:sid . :s107.10) (:did . :|92156807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000983@unknown@formal@none@1@S@Interleukin 6-induced differentiation of a human B cell line into IgM-secreting plasma cells is mediated by c-fos.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "6-induced") (:form . "6-induced") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 37) (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "igm-secreting") (:form . "IgM-secreting")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s108.1) (:did . :|92164748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000984@unknown@formal@none@1@S@The role of the protooncogene c-fos in interleukin ( IL ) 6-induced B cell differentiation was assessed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 29) (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "6-induced") (:form . "6-induced") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 90) (:start . 75) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s108.2) (:did . :|92164748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000985@unknown@formal@none@1@S@Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SKW") (:form . "SKW") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "6.4") (:form . "6.4") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 78)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s108.3) (:did . :|92164748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000986@unknown@formal@none@1@S@The effect appeared within 30 min and returned to basal levels after 2 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s108.4) (:did . :|92164748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000987@unknown@formal@none@1@S@The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 42) (:start . 26) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 65) (:start . 52) (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "6-induced") (:form . "6-induced") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NNP") (:stem . "IgM") (:form . "IgM") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SKW") (:form . "SKW") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "CD") (:stem . "6.4") (:form . "6.4") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 174) (:start . 158) (:id . 68))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 192)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 199)\n  (:start . 193) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x108.5.1) (:span 179 181)))\n (:nscopes ((:id . :x108.5.1) (:span 179 199)))\n (:identifiers (:sid . :s108.5) (:did . :|92164748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000988@unknown@formal@none@1@S@These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "6-induced") (:form . "6-induced") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 91) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SKW") (:form . "SKW") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "CD") (:stem . "6.4") (:form . "6.4") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "igm-secreting") (:form . "IgM-secreting")\n  (:end . 127) (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x108.6.1) (:span 14 27)))\n (:hscopes ((:id . :x108.6.1) (:span 14 133)))\n (:identifiers (:sid . :s108.6) (:did . :|92164748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000990@unknown@formal@none@1@S@To clarify the molecular mechanisms involved in the developmental control of hemoglobin-encoding genes we have been studying the expression of these genes in human cells in continuous culture.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "clarify") (:form . "clarify") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hemoglobin-encoding")\n  (:form . "hemoglobin-encoding") (:end . 96) (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 169)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 183)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 191)\n  (:start . 184) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s109.2) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000991@unknown@formal@none@1@S@We have previously reported the presence of a transcriptional control element with the properties of a silencer extending from -392 to -177 bp relative to the cap site of the human epsilon-globin-encoding gene [Cao et al., Proc.Natl.Acad.Sci.USA 86 ( 1989 ) 5306-5309].@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 61) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-392") (:form . "-392") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "CD") (:stem . "-177") (:form . "-177") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 151)\n  (:start . 143) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cap") (:form . "cap") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 180)\n  (:start . 175) (:id . 72))\n ((:tag . "JJ") (:stem . "epsilon-globin-encoding")\n  (:form . "epsilon-globin-encoding") (:end . 204) (:start . 181) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 211) (:start . 210)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Cao") (:form . "Cao") (:end . 214) (:start . 211)\n  (:id . 76))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 217) (:start . 215)\n  (:id . 77))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 221) (:start . 218)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Proc.Natl.Acad.Sci.USA")\n  (:form . "Proc.Natl.Acad.Sci.USA") (:end . 245) (:start . 223) (:id . 80))\n ((:tag . "CD") (:stem . "86") (:form . "86") (:end . 248) (:start . 246)\n  (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 250) (:start . 249)\n  (:id . 82))\n ((:tag . "CD") (:stem . "1989") (:form . "1989") (:end . 255) (:start . 251)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 257) (:start . 256)\n  (:id . 84))\n ((:tag . "CD") (:stem . "5306-5309") (:form . "5306-5309") (:end . 267)\n  (:start . 258) (:id . 85))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 268) (:start . 267)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s109.3) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000992@unknown@formal@none@1@S@We also showed that this silencer has stronger inhibitory activity in HeLa cells, as compared to K562 human erythroleukemia cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 123) (:start . 108) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s109.4) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000993@unknown@formal@none@1@S@Using deletion mutants and cis-cloned synthetic oligodeoxyribonucleotides in transient expression assays, nucleotide sequences responsible for this effect have now been further delimited to 44 bp located from -294 to -251 bp.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cis-cloned") (:form . "cis-cloned") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "oligodeoxyribonucleotide")\n  (:form . "oligodeoxyribonucleotides") (:end . 73) (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 86)\n  (:start . 77) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 51))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 104)\n  (:start . 98) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 116)\n  (:start . 106) (:id . 54))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 126)\n  (:start . 117) (:id . 55))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 138)\n  (:start . 127) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 147) (:start . 143)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 154)\n  (:start . 148) (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 159) (:start . 155)\n  (:id . 60))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 163) (:start . 160)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 168) (:start . 164)\n  (:id . 62))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 176)\n  (:start . 169) (:id . 63))\n ((:tag . "VBN") (:stem . "delimit") (:form . "delimited") (:end . 186)\n  (:start . 177) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 65))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 192) (:start . 190)\n  (:id . 66))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 195) (:start . 193)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 203)\n  (:start . 196) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 208) (:start . 204)\n  (:id . 69))\n ((:tag . "CD") (:stem . "-294") (:form . "-294") (:end . 213) (:start . 209)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 216) (:start . 214)\n  (:id . 71))\n ((:tag . "CD") (:stem . "-251") (:form . "-251") (:end . 221) (:start . 217)\n  (:id . 72))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 224) (:start . 222)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s109.5) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000994@unknown@formal@none@1@S@Gel electrophoresis mobility shift assays and DNaseI footprinting assays demonstrate that these negative regulatory sequences are recognized differently by proteins present in nuclear extracts obtained from HeLa and K562 cells.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DNaseI") (:form . "DNaseI") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 72)\n  (:start . 66) (:id . 50))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 84)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 95) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 115)\n  (:start . 105) (:id . 55))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 125)\n  (:start . 116) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 129) (:start . 126)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 140)\n  (:start . 130) (:id . 58))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 152)\n  (:start . 141) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 164)\n  (:start . 156) (:id . 61))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 172)\n  (:start . 165) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 183)\n  (:start . 176) (:id . 64))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 192)\n  (:start . 184) (:id . 65))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 201)\n  (:start . 193) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 206) (:start . 202)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 211) (:start . 207)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 69))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 220) (:start . 216)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s109.6) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000995@unknown@formal@none@1@S@Two binding proteins are detected in K562 nuclear extracts, while only one is found in extracts from HeLa cells.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 11) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s109.7) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000996@unknown@formal@none@1@S@Possible mechanisms by which these proteins may regulate transcription of the epsilon-globin-encoding gene in erythroid and non-erythroid cells are discussed.@(((:tag . "JJ") (:stem . "possible") (:form . "Possible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "epsilon-globin-encoding")\n  (:form . "epsilon-globin-encoding") (:end . 101) (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 119)\n  (:start . 110) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "non-erythroid") (:form . "non-erythroid")\n  (:end . 137) (:start . 124) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 147) (:start . 144)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 157)\n  (:start . 148) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x109.8.1) (:span 44 47)) ((:id . :x109.8.2) (:span 0 8)))\n (:hscopes ((:id . :x109.8.1) (:span 44 143))\n  ((:id . :x109.8.2) (:span 0 143)))\n (:identifiers (:sid . :s109.8) (:did . :|92165059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5000997@unknown@formal@none@1@S@Gangliosides suppress tumor necrosis factor production in human monocytes.@(((:tag . "NNP") (:stem . "Ganglioside") (:form . "Gangliosides") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 27) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 54)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s110.1) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5000998@unknown@formal@none@1@S@Both normal and malignant cells contain gangliosides as important cell membrane constituents that, after being shed, may influence cells of the immune system.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "constituent") (:form . "constituents") (:end . 92)\n  (:start . 80) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 110) (:start . 105)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "shed") (:form . "shed") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x110.2.1) (:span 117 120)))\n (:hscopes ((:id . :x110.2.1) (:span 117 157)))\n (:identifiers (:sid . :s110.2) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001000@unknown@formal@none@1@S@Although under standard culture conditions, bovine brain gangliosides (100 micrograms/ml) suppressed LPS-stimulated TNF production 5-fold in PBMC and 10-fold in Mono Mac 6 cells, suppression was more efficient under serum-free conditions.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "micrograms/ml") (:form . "micrograms/ml")\n  (:end . 88) (:start . 75) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 115) (:start . 101) (:id . 56))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 130)\n  (:start . 120) (:id . 58))\n ((:tag . "RB") (:stem . "5-fold") (:form . "5-fold") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 157)\n  (:start . 150) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 190)\n  (:start . 179) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 209)\n  (:start . 200) (:id . 73))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 215)\n  (:start . 210) (:id . 74))\n ((:tag . "JJ") (:stem . "serum-free") (:form . "serum-free") (:end . 226)\n  (:start . 216) (:id . 75))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 237)\n  (:start . 227) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s110.4) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001001@unknown@formal@none@1@S@Looking at highly purified gangliosides, GD3, GD1a, GM3, GM2, and GM1 were all effective in reducing TNF production in PBMC, and in Mono Mac 6 by factor 10 to 50.@(((:tag . "VBG") (:stem . "look") (:form . "Looking") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GD3") (:form . "GD3") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GD1a") (:form . "GD1a") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GM3") (:form . "GM3") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gm2") (:form . "GM2") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GM1") (:form . "GM1") (:end . 69) (:start . 66)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 74) (:start . 70)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 88)\n  (:start . 79) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 100)\n  (:start . 92) (:id . 62))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 115)\n  (:start . 105) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 123) (:start . 119)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 136) (:start . 132)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 140) (:start . 137)\n  (:id . 71))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 142) (:start . 141)\n  (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 152)\n  (:start . 146) (:id . 74))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 155) (:start . 153)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 76))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 161) (:start . 159)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s110.5) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001002@unknown@formal@none@1@S@The suppressive activity was lost in molecules, lacking the sugar moiety or the lipid moiety.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sugar") (:form . "sugar") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "moiety") (:form . "moiety") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "moiety") (:form . "moiety") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x110.6.1) (:span 73 75)))\n (:ncues ((:id . :x110.6.2) (:span 48 55)))\n (:hscopes ((:id . :x110.6.1) (:span 56 92)))\n (:nscopes ((:id . :x110.6.2) (:span 48 92)))\n (:identifiers (:sid . :s110.6) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001003@unknown@formal@none@1@S@Gangliosides appear to act at an early step of activation in that TNF transcripts were reduced and the mobilization of the nuclear factor kappa B was blocked.@(((:tag . "NNS") (:stem . "ganglioside") (:form . "Gangliosides") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 19)\n  (:start . 13) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 115)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 130)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 157)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x110.7.1) (:span 13 19)))\n (:hscopes ((:id . :x110.7.1) (:span 0 57)))\n (:identifiers (:sid . :s110.7) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001004@unknown@formal@none@1@S@Furthermore, in time kinetics, gangliosides were effective for up to 30 min after addition of LPS, but not thereafter.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thereafter") (:form . "thereafter") (:end . 117)\n  (:start . 107) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x110.8.1) (:span 103 106)))\n (:nscopes ((:id . :x110.8.1) (:span 103 117)))\n (:identifiers (:sid . :s110.8) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001005@unknown@formal@none@1@S@However, the expression of the CD14 Ag, a receptor molecule for LPS-LPS binding protein complexes, was unaffected by gangliosides.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS-LPS") (:form . "LPS-LPS") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 129)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s110.9) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001006@unknown@formal@none@1@S@Finally, when using Staphylococcus aureus or platelet activating factor as a stimulus, gangliosides were able to suppress TNF production in Mono Mac 6 cells by factor 5 to 10, as well.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "FW") (:stem . "staphylococcus") (:form . "Staphylococcus")\n  (:end . 34) (:start . 20) (:id . 46))\n ((:tag . "FW") (:stem . "aureus") (:form . "aureus") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 178) (:start . 176)\n  (:id . 74))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 183) (:start . 179)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s110.10) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001007@unknown@formal@none@1@S@On the other hand, phorbol ester-induced production of O2- was similar in cells treated with and without gangliosides.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "JJ") (:stem . "ester-induced") (:form . "ester-induced")\n  (:end . 40) (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "O2-") (:form . "O2-") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 117)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x110.11.1) (:span 97 104)))\n (:nscopes ((:id . :x110.11.1) (:span 97 117)))\n (:identifiers (:sid . :s110.11) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001008@unknown@formal@none@1@S@Taken together, our data demonstrate that TNF gene expression in monocytes induced by different types of stimuli can be blocked by gangliosides at an early step of signal transduction.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 143)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 183)\n  (:start . 171) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s110.12) (:did . :|92176633|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001010@unknown@formal@none@1@S@IL-4 secreted by activated T cells is a pleiotropic cytokine affecting growth and differentiation of diverse cell types such as T cells, B cells, and mast cells.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 51)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 97) (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s111.2) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001011@unknown@formal@none@1@S@We investigated the upstream regulatory elements of the human IL-4 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s111.3) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001012@unknown@formal@none@1@S@A novel T cell-specific negative regulatory element (NRE) composed of two protein-binding sites were mapped in the 5' flanking region of the IL-4 gene: -311CTCCCTTCT-303 (NRE-I) and -288CTTTTTGCTT-TGC-300 (NRE-II).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "protein-binding") (:form . "protein-binding")\n  (:end . 89) (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "-311CTCCCTTCT-303") (:form . "-311CTCCCTTCT-303")\n  (:end . 169) (:start . 152) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NRE-I") (:form . "NRE-I") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "-288CTTTTTGCTT-TGC-300")\n  (:form . "-288CTTTTTGCTT-TGC-300") (:end . 204) (:start . 182) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NRE-II") (:form . "NRE-II") (:end . 212)\n  (:start . 206) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s111.4) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001013@unknown@formal@none@1@S@A T cell-specific protein Neg-1 and a ubiquitous protein Neg-2 binding to NRE-I and NRE-II, respectively, were identified.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 3) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 17) (:start . 4) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "neg-1") (:form . "Neg-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "neg-2") (:form . "Neg-2") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NRE-I") (:form . "NRE-I") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NRE-II") (:form . "NRE-II") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 104)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s111.5) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001014@unknown@formal@none@1@S@Furthermore, a positive regulatory element was found 45 bp downstream of the NRE.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nre") (:form . "NRE") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s111.6) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001015@unknown@formal@none@1@S@The enhancer activity of the PRE was completely suppressed when the NRE was present.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pre") (:form . "PRE") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nre") (:form . "NRE") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s111.7) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001016@unknown@formal@none@1@S@These data suggest that IL-4 promoter activity is normally down-regulated by an NRE via repression of the enhancer positive regulatory element.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 73) (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nre") (:form . "NRE") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x111.8.1) (:span 11 18)))\n (:hscopes ((:id . :x111.8.1) (:span 11 142)))\n (:identifiers (:sid . :s111.8) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001017@unknown@formal@none@1@S@These data may have implications for the stringent control of IL-4 expression in T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "stringent") (:form . "stringent") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x111.9.1) (:span 11 14)))\n (:hscopes ((:id . :x111.9.1) (:span 11 88)))\n (:identifiers (:sid . :s111.9) (:did . :|92176657|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001018@unknown@formal@none@1@S@[Regulatory effect of insulin on glucocorticoid receptor in human peripheral leukocytes]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "Regulatory") (:end . 11)\n  (:start . 1) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 47) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s112.1) (:did . :|92179751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001020@unknown@formal@none@1@S@After 3 h incubation the specific binding power with [3H] Dex was decreased by 23.3 ± 10.0, 32.2 ± 13.2 and 54.3 ± 9.2% (P greater than 0.05, P greater than 0.05 and P less than 0.01 as compared with the control value of 100 in the absence of insulin) respectively in the presence of 20 mU/L (physiological testing concentration), 200 mU/L (physiological upper limit) and 2,000 mU/L (pharmacological concentration) insulin in the incubation medium.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . 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5001021@unknown@formal@none@1@S@After 24 h incubation the decrease of these values increased respectively to 43.5 ± 19.0, 56.1 ± 20.7 and 80.2 ± 15.5 (P less than 0.05, P less than 0.01 and P less than 0.01 compared with control).@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "CD") (:stem . "43.5") (:form . "43.5") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "19.0") (:form . "19.0") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "CD") (:stem . "56.1") (:form . "56.1") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "CD") (:stem . "20.7") (:form . "20.7") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "CD") (:stem . "80.2") (:form . "80.2") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "CD") (:stem . "15.5") (:form . "15.5") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 120) (:start . 119)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 125) (:start . 121)\n  (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 130) (:start . 126)\n  (:id . 68))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 135) (:start . 131)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 138) (:start . 137)\n  (:id . 71))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 143) (:start . 139)\n  (:id . 72))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 148) (:start . 144)\n  (:id . 73))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 153) (:start . 149)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 159) (:start . 158)\n  (:id . 76))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 164) (:start . 160)\n  (:id . 77))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 169) (:start . 165)\n  (:id . 78))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 174) (:start . 170)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 183)\n  (:start . 175) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 81))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 196)\n  (:start . 189) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s112.4) (:did . :|92179751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001022@unknown@formal@none@1@S@Thus the inhibitory effect of insulin on the GR binding power is both dose- and time-dependent, which strongly suggests that GR is tonically controlled by insulin concentration change under physiological conditions.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dose-") (:form . "dose-") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 94) (:start . 80) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 59))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "RB") (:stem . "tonically") (:form . "tonically") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 151)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 176) (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 189)\n  (:start . 184) (:id . 71))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 203) (:start . 190) (:id . 72))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 214)\n  (:start . 204) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x112.5.1) (:span 111 119)))\n (:hscopes ((:id . :x112.5.1) (:span 111 214)))\n (:identifiers (:sid . :s112.5) (:did . :|92179751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001023@unknown@formal@none@1@S@Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "activation-inducer") (:form . "activation-inducer")\n  (:end . 54) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "molecule/cd69") (:form . "molecule/CD69")\n  (:end . 68) (:start . 55) (:id . 49))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 114)\n  (:start . 108) (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 119) (:start . 115)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s113.1) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001024@unknown@formal@none@1@S@The induction of the AP-1 transcription factor has been ascribed to the early events leading to T cell differentiation and activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "ascribe") (:form . "ascribed") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 118) (:start . 103) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s113.2) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001025@unknown@formal@none@1@S@We have studied the regulation of AP-1 activity in human peripheral blood T lymphocytes stimulated through the activation inducer molecule ( AIM ) /CD69 activation pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "AIM") (:form . "AIM") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "/CD69") (:form . "/CD69") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s113.3) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001026@unknown@formal@none@1@S@Phorbol esters are required to induce AIM/CD69 cell-surface expression as well as for triggering the proliferation of T cells in conjunction with anti-AIM mAb.@(((:tag . "NNP") (:stem . "Phorbol") (:form . "Phorbol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "AIM/CD69") (:form . "AIM/CD69") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "cell-surface") (:form . "cell-surface") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "trigger") (:form . "triggering") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 114) (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "anti-aim") (:form . "anti-AIM") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s113.4) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001027@unknown@formal@none@1@S@Mobility shift assays showed that addition of anti-AIM mAb to PMA-treated T lymphocytes markedly enhanced the binding activity of AP-1 to its cognate sequence, the phorbol ester response element.@(((:tag . "NN") (:stem . "mobility") (:form . "Mobility") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 28) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-aim") (:form . "anti-AIM") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pma-treated") (:form . "PMA-treated") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 126)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s113.5) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001028@unknown@formal@none@1@S@In contrast, anti-AIM mAb did not induce any change in the binding activity of NF-kappa B, a transcription factor whose activity is also regulated by protein kinase C.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "anti-aim") (:form . "anti-AIM") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 146)\n  (:start . 137) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 157)\n  (:start . 150) (:id . 69))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 164)\n  (:start . 158) (:id . 70))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 166) (:start . 165)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x113.6.1) (:span 30 33)))\n (:nscopes ((:id . :x113.6.1) (:span 30 166)))\n (:identifiers (:sid . :s113.6) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001030@unknown@formal@none@1@S@Blockade of the DNA-binding complexes with an anti-Fos mAb demonstrated a direct participation of c-Fos in the AP-1 complexes induced by anti-AIM mAb.@(((:tag . "NN") (:stem . "blockade") (:form . "Blockade") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-fos") (:form . "anti-Fos") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 94) (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "anti-aim") (:form . "anti-AIM") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s113.8) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001031@unknown@formal@none@1@S@Most of the AP-1 activity could be eliminated when the anti-AIM mAb was added to the culture medium in the presence of cycloheximide, suggesting that de novo protein synthesis is crucial for the induction of AP-1-binding activity.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "eliminate") (:form . "eliminated") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "anti-aim") (:form . "anti-AIM") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 132) (:start . 119) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 165)\n  (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 175)\n  (:start . 166) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 186)\n  (:start . 179) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 75))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 204)\n  (:start . 195) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 220)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 229)\n  (:start . 221) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x113.9.1) (:span 134 144)))\n (:hscopes ((:id . :x113.9.1) (:span 134 229)))\n (:identifiers (:sid . :s113.9) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001032@unknown@formal@none@1@S@These data provide the evidence that activation of human peripheral blood T cells through the AIM activation pathway regulate the activity of AP-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AIM") (:form . "AIM") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s113.10) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001033@unknown@formal@none@1@S@Therefore, this pathway appears as a crucial step in the initiation of early T cell activation events.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x113.11.1) (:span 24 31)))\n (:hscopes ((:id . :x113.11.1) (:span 24 101)))\n (:identifiers (:sid . :s113.11) (:did . :|92185243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001034@unknown@formal@none@1@S@cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.@(((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 66)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 75)\n  (:start . 67) (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 80) (:start . 76)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 88) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "Ets-related") (:end . 100)\n  (:start . 89) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s114.1) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001035@unknown@formal@none@1@S@The recent definition of a consensus DNA binding sequence for the Ets family of transcription factors has allowed the identification of potential Ets binding sites in the promoters and enhancers of many inducible T-cell genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "allow") (:form . "allowed") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 132) (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 180)\n  (:start . 171) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 194)\n  (:start . 185) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 202) (:start . 198)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 212)\n  (:start . 203) (:id . 74))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 219)\n  (:start . 213) (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s114.2) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001036@unknown@formal@none@1@S@In the studies described in this report, we have identified two potential Ets binding sites, EBS1 and EBS2, which are conserved in both the human and murine interleukin-2 enhancers.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EBS1") (:form . "EBS1") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EBS2") (:form . "EBS2") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 127)\n  (:start . 118) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 145)\n  (:start . 140) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 156)\n  (:start . 150) (:id . 71))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 170) (:start . 157) (:id . 72))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 180)\n  (:start . 171) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x114.3.1) (:span 64 73)))\n (:hscopes ((:id . :x114.3.1) (:span 64 91)))\n (:identifiers (:sid . :s114.3) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001037@unknown@formal@none@1@S@Within the human enhancer, these two sites are located within the previously defined DNase I footprints, NFAT-1 and NFIL-2B, respectively.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "footprint") (:form . "footprints") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NFAT-1") (:form . "NFAT-1") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NFIL-2B") (:form . "NFIL-2B") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 137)\n  (:start . 125) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s114.4) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001038@unknown@formal@none@1@S@Electrophoretic mobility shift and methylation interference analyses demonstrated that EBS1 and EBS2 are essential for the formation of the NFAT-1 and NFIL-2B nuclear protein complexes.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 59)\n  (:start . 47) (:id . 47))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 68)\n  (:start . 60) (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 81)\n  (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBS1") (:form . "EBS1") (:end . 91) (:start . 87)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EBS2") (:form . "EBS2") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 114)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 132)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NFAT-1") (:form . "NFAT-1") (:end . 146)\n  (:start . 140) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NFIL-2B") (:form . "NFIL-2B") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 174)\n  (:start . 167) (:id . 65))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 184)\n  (:start . 175) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s114.5) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001040@unknown@formal@none@1@S@Two well-characterized Ets family members, Ets-1 and Ets-2, are reciprocally expressed during T-cell activation.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "well-characterized") (:form . "well-characterized")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ets-2") (:form . "Ets-2") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "reciprocally") (:form . "reciprocally") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s114.7) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001041@unknown@formal@none@1@S@Surprisingly, however, neither of these proteins bound in vitro to EBS1 or EBS2.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBS1") (:form . "EBS1") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "EBS2") (:form . "EBS2") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x114.8.1) (:span 23 30)))\n (:nscopes ((:id . :x114.8.1) (:span 23 79)))\n (:identifiers (:sid . :s114.8) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001042@unknown@formal@none@1@S@We therefore screened a T-cell cDNA library under low-stringency conditions with a probe from the DNA binding domain of Ets-1 and isolated a novel Ets family member, Elf-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "screen") (:form . "screened") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "low-stringency") (:form . "low-stringency")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 157)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s114.9) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001043@unknown@formal@none@1@S@Elf-1 contains a DNA binding domain that is nearly identical to that of E74, the ecdysone-inducible Drosophila transcription factor required for metamorphosis (hence the name Elf-1, for E74-like factor 1).@(((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "e74") (:form . "E74") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ecdysone-inducible") (:form . "ecdysone-inducible")\n  (:end . 99) (:start . 81) (:id . 58))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 158) (:start . 145) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 65))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "name") (:form . "name") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 180)\n  (:start . 175) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "e74-like") (:form . "E74-like") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 203) (:start . 202)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s114.10) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001044@unknown@formal@none@1@S@Elf-1 bound specifically to both EBS1 and EBS2 in electrophoretic mobility shift assays.@(((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ebs1") (:form . "EBS1") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ebs2") (:form . "EBS2") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 65) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s114.11) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001045@unknown@formal@none@1@S@It also bound to the purine-rich CD3R element from the human immunodeficiency virus type 2 long terminal repeat, which is required for inducible virus expression in response to signalling through the T-cell receptor.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 32)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "cd3r") (:form . "CD3R") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 77) (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 161)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 173)\n  (:start . 165) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 187)\n  (:start . 177) (:id . 71))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 195)\n  (:start . 188) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 206)\n  (:start . 200) (:id . 74))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 215)\n  (:start . 207) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s114.12) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001046@unknown@formal@none@1@S@Taken together, these results demonstrate that multiple Ets family members with apparently distinct DNA binding specificities regulate differential gene expression in resting and activated T cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "NNS") (:stem . "specificity") (:form . "specificities")\n  (:end . 125) (:start . 112) (:id . 58))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 147)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 174)\n  (:start . 167) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 188)\n  (:start . 179) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 190) (:start . 189)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s114.13) (:did . :|92186836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001047@unknown@formal@none@1@S@Mineralocorticoids and mineralocorticoid receptors in mononuclear leukocytes in patients with pregnancy-induced hypertension.@(((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "Mineralocorticoids")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 40) (:start . 23) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 50)\n  (:start . 41) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 65)\n  (:start . 54) (:id . 47))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 76)\n  (:start . 66) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 88)\n  (:start . 80) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pregnancy-induced") (:form . "pregnancy-induced")\n  (:end . 111) (:start . 94) (:id . 52))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 124)\n  (:start . 112) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s115.1) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001048@unknown@formal@none@1@S@To examine the role of mineralocorticoids in the pathophysiology of pregnancy-induced hypertension (PIH), we studied plasma aldosterone and 18-hydroxycorticosterone levels in 25 women with PIH and 25 normal pregnant women, as controls.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 41) (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pregnancy-induced") (:form . "pregnancy-induced")\n  (:end . 85) (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 98)\n  (:start . 86) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "18-hydroxycorticosterone")\n  (:form . "18-hydroxycorticosterone") (:end . 164) (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 171)\n  (:start . 165) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 65))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 183)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 70))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 206)\n  (:start . 200) (:id . 72))\n ((:tag . "JJ") (:stem . "pregnant") (:form . "pregnant") (:end . 215)\n  (:start . 207) (:id . 73))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 221)\n  (:start . 216) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 225) (:start . 223)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 234)\n  (:start . 226) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s115.2) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001050@unknown@formal@none@1@S@MR count was significantly (P less than 0.0005) decreased in the PIH group (148 ± 9 binding sites/cell) compared with the control group (300 ± 17 binding sites/cell; mean ± SEM).@(((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "count") (:form . "count") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.0005") (:form . "0.0005") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "CD") (:stem . "148") (:form . "148") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 83) (:start . 82)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 91)\n  (:start . 84) (:id . 61))\n ((:tag . "NNS") (:stem . "sites/cell") (:form . "sites/cell") (:end . 102)\n  (:start . 92) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 112)\n  (:start . 104) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 129)\n  (:start . 122) (:id . 67))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 69))\n ((:tag . "CD") (:stem . "300") (:form . "300") (:end . 140) (:start . 137)\n  (:id . 70))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 142) (:start . 141)\n  (:id . 71))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 145) (:start . 143)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 153)\n  (:start . 146) (:id . 73))\n ((:tag . "NNS") (:stem . "sites/cell") (:form . "sites/cell") (:end . 164)\n  (:start . 154) (:id . 74))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 165) (:start . 164)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 170) (:start . 166)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 172) (:start . 171)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 176) (:start . 173)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s115.4) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001051@unknown@formal@none@1@S@Plasma aldosterone in women with PIH was 281 ± 61 pmol/L;@(((:tag . "NN") (:stem . "plasma") (:form . "Plasma") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "281") (:form . "281") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "±") (:form . "±") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "61") (:form . "61") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pmol/l") (:form . "pmol/L") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 57) (:start . 56)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s115.5) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001052@unknown@formal@none@1@S@in normal pregnant women it was 697 ± 172 pmol/L (P less than 0.025).@(((:tag . "IN") (:stem . "in") (:form . "in") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pregnant") (:form . "pregnant") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "697") (:form . "697") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "±") (:form . "±") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "CD") (:stem . "172") (:form . "172") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pmol/l") (:form . "pmol/L") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 56) (:start . 52)\n  (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 61) (:start . 57)\n  (:id . 55))\n ((:tag . "CD") (:stem . "0.025") (:form . "0.025") (:end . 67) (:start . 62)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s115.6) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001053@unknown@formal@none@1@S@Plasma 18-hydroxycorticosterone was also significantly (P less than 0.025) lower (PIH, 1071 ± 149 pmol/L; controls, 1907 ± 318 pmol/L).@(((:tag . "NN") (:stem . "plasma") (:form . "Plasma") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "18-hydroxycorticosterone")\n  (:form . "18-hydroxycorticosterone") (:end . 31) (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 54) (:start . 41) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 57) (:start . 56)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "CD") (:stem . "0.025") (:form . "0.025") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1071") (:form . "1071") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "149") (:form . "149") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pmol/l") (:form . "pmol/L") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1907") (:form . "1907") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "CD") (:stem . "318") (:form . "318") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pmol/l") (:form . "pmol/L") (:end . 133)\n  (:start . 127) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s115.7) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001054@unknown@formal@none@1@S@These values were determined at the onset of clinical symptoms of PIH.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s115.8) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001055@unknown@formal@none@1@S@These results can not be explained by receptor down-regulation due to higher levels of mineralocorticoids in PIH;@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 76) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 105) (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x115.9.1) (:span 14 21)))\n (:nscopes ((:id . :x115.9.1) (:span 0 62)))\n (:identifiers (:sid . :s115.9) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001056@unknown@formal@none@1@S@a hitherto unknown mineralocorticoid may , thus, be responsible for the hypertension and altered MR status.@(((:tag . "DT") (:stem . "a") (:form . "a") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "hitherto") (:form . "hitherto") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 36) (:start . 19) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "mr") (:form . "MR") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x115.10.1) (:span 37 40)))\n (:hscopes ((:id . :x115.10.1) (:span 37 106)))\n (:identifiers (:sid . :s115.10) (:did . :|92193465|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001057@unknown@formal@none@1@S@Mineralocorticoid effector mechanism in preeclampsia.@(((:tag . "NN") (:stem . "mineralocorticoid") (:form . "Mineralocorticoid")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 26)\n  (:start . 18) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 36)\n  (:start . 27) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "preeclampsia") (:form . "preeclampsia") (:end . 52)\n  (:start . 40) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s116.1) (:did . :|92193472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001058@unknown@formal@none@1@S@Mineralocorticoid effector mechanisms were evaluated in 29 patients with preeclampsia and in 25 uncomplicated pregnancies by measurement of plasma aldosterone, levels of mineralocorticoid receptor (MR) in mononuclear leucocytes, and subtraction potential difference (SPD; rectal minus oral values).@(((:tag . "NN") (:stem . "mineralocorticoid") (:form . "Mineralocorticoid")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 26)\n  (:start . 18) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 37)\n  (:start . 27) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 52)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 47))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "preeclampsia") (:form . "preeclampsia") (:end . 85)\n  (:start . 73) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "uncomplicated") (:form . "uncomplicated")\n  (:end . 109) (:start . 96) (:id . 55))\n ((:tag . "NNS") (:stem . "pregnancy") (:form . "pregnancies") (:end . 121)\n  (:start . 110) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "NN") (:stem . "measurement") (:form . "measurement") (:end . 136)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 59))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 146)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 158)\n  (:start . 147) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 166)\n  (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 187) (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 196)\n  (:start . 188) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 200) (:start . 198)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 201) (:start . 200)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 216)\n  (:start . 205) (:id . 71))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 227)\n  (:start . 217) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 232) (:start . 229)\n  (:id . 74))\n ((:tag . "NN") (:stem . "subtraction") (:form . "subtraction") (:end . 244)\n  (:start . 233) (:id . 75))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 254)\n  (:start . 245) (:id . 76))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 265)\n  (:start . 255) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 267) (:start . 266)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "SPD") (:form . "SPD") (:end . 270) (:start . 267)\n  (:id . 79))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 271) (:start . 270)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "rectal") (:form . "rectal") (:end . 278)\n  (:start . 272) (:id . 81))\n ((:tag . "CC") (:stem . "minus") (:form . "minus") (:end . 284)\n  (:start . 279) (:id . 82))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 289) (:start . 285)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 296)\n  (:start . 290) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 297) (:start . 296)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 298) (:start . 297)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s116.2) (:did . :|92193472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001060@unknown@formal@none@1@S@In six cases we determined MR, plasma aldosterone, and SPD in patients with preeclampsia before and 3 months after delivery.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "spd") (:form . "SPD") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "preeclampsia") (:form . "preeclampsia") (:end . 88)\n  (:start . 76) (:id . 57))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 108)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s116.4) (:did . :|92193472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001061@unknown@formal@none@1@S@MR were reduced before delivery (96 ± 27 receptors/cell), and SPD increased (64 ± 8 mV), with both parameters normalizing after delivery (MR, 242 ± 79; SPD, 14.0 ± 4 mV).@(((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "96") (:form . "96") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptors/cell") (:form . "receptors/cell")\n  (:end . 55) (:start . 41) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "spd") (:form . "SPD") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 75)\n  (:start . 66) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "CD") (:stem . "64") (:form . "64") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 83) (:start . 82)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mv") (:form . "mV") (:end . 86) (:start . 84)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 98) (:start . 94)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 109)\n  (:start . 99) (:id . 66))\n ((:tag . "VBG") (:stem . "normalize") (:form . "normalizing") (:end . 121)\n  (:start . 110) (:id . 67))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 127)\n  (:start . 122) (:id . 68))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 136)\n  (:start . 128) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 140) (:start . 138)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 72))\n ((:tag . "CD") (:stem . "242") (:form . "242") (:end . 145) (:start . 142)\n  (:id . 73))\n ((:tag . ",") (:stem . "±") (:form . "±") (:end . 147) (:start . 146)\n  (:id . 74))\n ((:tag . "CD") (:stem . "79") (:form . "79") (:end . 150) (:start . 148)\n  (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 151) (:start . 150)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "SPD") (:form . "SPD") (:end . 155) (:start . 152)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 78))\n ((:tag . "CD") (:stem . "14.0") (:form . "14.0") (:end . 161) (:start . 157)\n  (:id . 79))\n ((:tag . ".") (:stem . "±") (:form . "±") (:end . 163) (:start . 162)\n  (:id . 80))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 165) (:start . 164)\n  (:id . 81))\n ((:tag . "NN") (:stem . "mv") (:form . "mV") (:end . 168) (:start . 166)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s116.5) (:did . :|92193472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001062@unknown@formal@none@1@S@Aldosterone levels returned to normal nonpregnant values after delivery.@(((:tag . "NNP") (:stem . "Aldosterone") (:form . "Aldosterone") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "nonpregnant") (:form . "nonpregnant") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s116.6) (:did . :|92193472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001063@unknown@formal@none@1@S@These data suggest an important role for abnormalities in mineralocorticoid effector mechanisms in the etiology of preeclampsia and could be an useful marker for diagnosis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 54)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 75) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "etiology") (:form . "etiology") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "preeclampsia") (:form . "preeclampsia") (:end . 127)\n  (:start . 115) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 171)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x116.7.1) (:span 132 137))\n  ((:id . :x116.7.2) (:span 11 18)))\n (:hscopes ((:id . :x116.7.1) (:span 132 171))\n  ((:id . :x116.7.2) (:span 11 127)))\n (:identifiers (:sid . :s116.7) (:did . :|92193472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001064@unknown@formal@none@1@S@A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "c-rel-like") (:form . "c-Rel-like") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 85) (:start . 71) (:id . 50))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 95)\n  (:start . 86) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 114) (:start . 101) (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 120)\n  (:start . 115) (:id . 54))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 130)\n  (:start . 121) (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 137)\n  (:start . 131) (:id . 56))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 143)\n  (:start . 138) (:id . 57))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 154)\n  (:start . 144) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 158) (:start . 155)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "repress") (:form . "repressed") (:end . 168)\n  (:start . 159) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 180)\n  (:start . 172) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s117.1) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001065@unknown@formal@none@1@S@The proto-oncoprotein c-Rel is a member of the nuclear factor kappa B transcription factor family, which includes the p50 and p65 subunits of nuclear factor kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proto-oncoprotein") (:form . "proto-oncoprotein")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 27) (:start . 22)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 58))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s117.2) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001066@unknown@formal@none@1@S@We show here that c-Rel binds to kappa B sites as homodimers as well as heterodimers with p50.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 60)\n  (:start . 50) (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 84)\n  (:start . 72) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s117.3) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001067@unknown@formal@none@1@S@These homodimers and heterodimers show distinct DNA-binding specificities and affinities for various kappa B motifs.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "specificity") (:form . "specificities") (:end . 73)\n  (:start . 60) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 88)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 100)\n  (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 106)\n  (:start . 101) (:id . 54))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s117.4) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001068@unknown@formal@none@1@S@In particular, the c-Rel homodimer has a high affinity for interleukin-6 (IL-6) and beta interferon kappa B sites.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 72) (:start . 59) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 99)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s117.5) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001070@unknown@formal@none@1@S@this factor, termed IL-6 kappa B binding factor II, appears to contain the c-Rel homodimer and preferentially recognizes several IL-6 kappa B-related kappa B motifs.@(((:tag . "DT") (:stem . "this") (:form . "this") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 19) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 109) (:start . 95) (:id . 60))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x117.7.1) (:span 95 109)) ((:id . :x117.7.2) (:span 52 59)))\n (:hscopes ((:id . :x117.7.1) (:span 95 164))\n  ((:id . :x117.7.2) (:span 0 90)))\n (:identifiers (:sid . :s117.7) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001071@unknown@formal@none@1@S@Although it has been previously shown that the IL-6 kappa B motif functions as a potent IL-1/tumor necrosis factor-responsive element in nonlymphoid cells, its activity was found to be repressed in lymphoid cells such as a Jurkat T-cell line.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "NNP") (:stem . "IL-1/tumor") (:form . "IL-1/tumor") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "JJ") (:stem . "factor-responsive") (:form . "factor-responsive")\n  (:end . 125) (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "repress") (:form . "repressed") (:end . 194)\n  (:start . 185) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 206)\n  (:start . 198) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 75))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 217) (:start . 213)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 220) (:start . 218)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 222) (:start . 221)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 229)\n  (:start . 223) (:id . 79))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 236)\n  (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 241) (:start . 237)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s117.8) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001072@unknown@formal@none@1@S@We also present evidence that IL-6 kappa B binding factor II functions as a repressor specific for IL-6 kappa B-related kappa B motifs in lymphoid cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s117.9) (:did . :|92195320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001073@unknown@formal@none@1@S@Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erbA oncogene action.@(((:tag . "NN") (:stem . "modulation") (:form . "Modulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 46) (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 154)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x118.1.1) (:span 112 120)))\n (:hscopes ((:id . :x118.1.1) (:span 112 154)))\n (:identifiers (:sid . :s118.1) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001074@unknown@formal@none@1@S@The v-erbA oncogene, a mutated version of the thyroid hormone receptor alpha (c-erbA/TR-alpha), inhibits erythroid differentiation and constitutively represses transcription of certain erythrocyte genes, suggesting a normal function of the proto-oncogene c-erbA in erythropoiesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "v-erba") (:form . "v-erbA") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-erba/tr-alpha") (:form . "c-erbA/TR-alpha")\n  (:end . 93) (:start . 78) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 130) (:start . 115) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 149) (:start . 135) (:id . 63))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 173) (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 184)\n  (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 196)\n  (:start . 185) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 202)\n  (:start . 197) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 214)\n  (:start . 204) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 216) (:start . 215)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 223)\n  (:start . 217) (:id . 73))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 232)\n  (:start . 224) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 76))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 254) (:start . 240) (:id . 77))\n ((:tag . "NN") (:stem . "c-erba") (:form . "c-erbA") (:end . 261)\n  (:start . 255) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 79))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 279) (:start . 265) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x118.2.1) (:span 204 214)))\n (:hscopes ((:id . :x118.2.1) (:span 204 279)))\n (:identifiers (:sid . :s118.2) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001075@unknown@formal@none@1@S@Here we demonstrate that the endogenous thyroid hormone receptor alpha (c-erbA/TR-alpha) and the closely related retinoic acid receptor alpha (RAR-alpha) play a role in the regulation of normal erythroid differentiation.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-erba/tr-alpha") (:form . "c-erbA/TR-alpha")\n  (:end . 87) (:start . 72) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RAR-alpha") (:form . "RAR-alpha") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 183)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 203)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 219) (:start . 204) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s118.3) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001076@unknown@formal@none@1@S@Retinoic acid (RA) distinctly modulated the erythroid differentiation program of normal erythroid progenitors and erythroblasts reversibly transformed by a conditional tyrosine kinase oncogene.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "distinctly") (:form . "distinctly") (:end . 29)\n  (:start . 19) (:id . 47))\n ((:tag . "VBD") (:stem . "modulate") (:form . "modulated") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 69) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 127) (:start . 114) (:id . 58))\n ((:tag . "RB") (:stem . "reversibly") (:form . "reversibly") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 150)\n  (:start . 139) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "conditional") (:form . "conditional") (:end . 167)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 176)\n  (:start . 168) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 183)\n  (:start . 177) (:id . 65))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 192)\n  (:start . 184) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s118.4) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001077@unknown@formal@none@1@S@When added pulsewise to immature cells, differentiation was accelerated while more mature cells underwent premature cell death.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "pulsewise") (:form . "pulsewise") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "accelerate") (:form . "accelerated") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "undergo") (:form . "underwent") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "JJ") (:stem . "premature") (:form . "premature") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s118.5) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001078@unknown@formal@none@1@S@Thyroid hormone (T3) alone caused similar but weaker effects.@(((:tag . "NN") (:stem . "thyroid") (:form . "Thyroid") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "weak") (:form . "weaker") (:end . 52) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s118.6) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001080@unknown@formal@none@1@S@Expression of the human RAR-alpha in receptor-negative erythroblasts conferred RA-induced regulation of differentiation to the otherwise unresponsive cells, thus showing that the RAR-alpha is essential for the RA effect.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAR-alpha") (:form . "RAR-alpha") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "receptor-negative") (:form . "receptor-negative")\n  (:end . 54) (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 68) (:start . 55) (:id . 49))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "JJ") (:stem . "ra-induced") (:form . "RA-induced") (:end . 89)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 100)\n  (:start . 90) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 119) (:start . 104) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 56))\n ((:tag . "RB") (:stem . "otherwise") (:form . "otherwise") (:end . 136)\n  (:start . 127) (:id . 57))\n ((:tag . "JJ") (:stem . "unresponsive") (:form . "unresponsive") (:end . 149)\n  (:start . 137) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 161) (:start . 157)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 169)\n  (:start . 162) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 174) (:start . 170)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "RAR-alpha") (:form . "RAR-alpha") (:end . 188)\n  (:start . 179) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 191) (:start . 189)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 201)\n  (:start . 192) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 205) (:start . 202)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 212) (:start . 210)\n  (:id . 70))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 219)\n  (:start . 213) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s118.8) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001081@unknown@formal@none@1@S@Likewise, enhanced expression of exogenous c-erbA/TR-alpha in erythroblasts rendered them susceptible to modulation of differentiation by T3, suggesting a similar function of both receptors.@(((:tag . "RB") (:stem . "likewise") (:form . "Likewise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "c-erba/tr-alpha") (:form . "c-erbA/TR-alpha")\n  (:end . 58) (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 75) (:start . 62) (:id . 50))\n ((:tag . "VBD") (:stem . "render") (:form . "rendered") (:end . 84)\n  (:start . 76) (:id . 51))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 101)\n  (:start . 90) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 115)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 134) (:start . 119) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 152)\n  (:start . 142) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 162)\n  (:start . 155) (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 171)\n  (:start . 163) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 65))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 189)\n  (:start . 180) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x118.9.1) (:span 142 152)))\n (:hscopes ((:id . :x118.9.1) (:span 142 189)))\n (:identifiers (:sid . :s118.9) (:did . :|92195648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001082@unknown@formal@none@1@S@Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.@(((:tag . "NNP") (:stem . "Leukotriene") (:form . "Leukotriene") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B4") (:form . "B4") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s119.1) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001083@unknown@formal@none@1@S@We have examined the effect of leukotriene B4 (LTB4), a potent lipid proinflammatory mediator, on the expression of the proto-oncogenes c-jun and c-fos.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "leukotriene") (:form . "leukotriene") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "b4") (:form . "B4") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LTB4") (:form . "LTB4") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 62)\n  (:start . 56) (:id . 55))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 68) (:start . 63)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 84) (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 135) (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 151)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s119.2) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001084@unknown@formal@none@1@S@In addition, we looked at the modulation of nuclear factors binding specifically to the AP-1 element after LTB4 stimulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "look") (:form . "looked") (:end . 22) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s119.3) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001085@unknown@formal@none@1@S@LTB4 increased the expression of the c-fos gene in a time- and concentration-dependent manner.@(((:tag . "NNP") (:stem . "LTB4") (:form . "LTB4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "time-") (:form . "time-") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 86) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s119.4) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001086@unknown@formal@none@1@S@The c-jun mRNA, which is constitutively expressed in human peripheral-blood monocytes at relatively high levels, was also slightly augmented by LTB4, although to a much lower extent than c-fos.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 39) (:start . 25) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral-blood") (:form . "peripheral-blood")\n  (:end . 75) (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "VBN") (:stem . "augment") (:form . "augmented") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 158)\n  (:start . 150) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 174) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 181)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 186) (:start . 182)\n  (:id . 72))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 192)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s119.5) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001087@unknown@formal@none@1@S@The kinetics of expression of the two genes were also slightly different, with c-fos mRNA reaching a peak at 15 min after stimulation and c-jun at 30 min.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "reach") (:form . "reaching") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 133)\n  (:start . 122) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s119.6) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001088@unknown@formal@none@1@S@Both messages rapidly declined thereafter.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "message") (:form . "messages") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "decline") (:form . "declined") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "RB") (:stem . "thereafter") (:form . "thereafter") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s119.7) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001090@unknown@formal@none@1@S@Nuclear transcription studies in vitro showed that LTB4 increased the transcription of the c-fos gene 7-fold and the c-jun gene 1.4-fold.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 45) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "RB") (:stem . "7-fold") (:form . "7-fold") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "RB") (:stem . "1.4-fold") (:form . "1.4-fold") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s119.9) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001091@unknown@formal@none@1@S@Resting monocytes contained nuclear factors binding to the AP-1 element, but stimulation of monocytes with LTB4 induced greater AP-1-binding activity of nuclear proteins.@(((:tag . "VBG") (:stem . "rest") (:form . "Resting") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 140)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 160)\n  (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 169)\n  (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s119.10) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001092@unknown@formal@none@1@S@These results indicate that LTB4 may regulate the production of different cytokines by modulating the yield and/or the function of transcription factors such as AP-1-binding proto-oncogene products.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "yield") (:form . "yield") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 173)\n  (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 188) (:start . 174) (:id . 67))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 197)\n  (:start . 189) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x119.11.1) (:span 108 114))\n  ((:id . :x119.11.2) (:span 33 36)) ((:id . :x119.11.3) (:span 14 27)))\n (:hscopes ((:id . :x119.11.1) (:span 98 127))\n  ((:id . :x119.11.2) (:span 33 197)) ((:id . :x119.11.3) (:span 14 197)))\n (:identifiers (:sid . :s119.11) (:did . :|92207144|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001093@unknown@formal@none@1@S@An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "11-base-pair") (:form . "11-base-pair") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 107) (:start . 93) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s120.1) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001094@unknown@formal@none@1@S@We have identified a DNA segment that confers responsiveness to antigen stimulation signals on the human interleukin (IL) 4 gene in Jurkat cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 60) (:start . 46) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 116)\n  (:start . 105) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s120.2) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001095@unknown@formal@none@1@S@The human IL-4 gene, of 10 kilobases, is composed of four exons and three introns.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 36)\n  (:start . 27) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 49)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 57) (:start . 53)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "intron") (:form . "introns") (:end . 81)\n  (:start . 74) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s120.3) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001096@unknown@formal@none@1@S@A cis-acting element (P sequence) resides in the 5' upstream region;@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "reside") (:form . "resides") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 60)\n  (:start . 52) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 67)\n  (:start . 61) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 68) (:start . 67)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s120.4) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001097@unknown@formal@none@1@S@no additional DNA segments with enhancer activity were identified in the human IL-4 gene.@(((:tag . "DT") (:stem . "no") (:form . "no") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x120.5.1) (:span 0 2)))\n (:nscopes ((:id . :x120.5.1) (:span 0 88)))\n (:identifiers (:sid . :s120.5) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001098@unknown@formal@none@1@S@For further mapping purposes, a fusion promoter was constructed with the granulocyte/macrophage colony-stimulating factor basic promoter containing 60 base pairs of sequence upstream from the cap site of the mouse granulocyte/macrophage colony-stimulating factor gene and various lengths of the 5' upstream sequence of the IL-4 gene.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "purpose") (:form . "purposes") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fusion") (:form . 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"promoter") (:form . "promoter") (:end . 136)\n  (:start . 128) (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 147)\n  (:start . 137) (:id . 59))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 150) (:start . 148)\n  (:id . 60))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 155) (:start . 151)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 161)\n  (:start . 156) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 173)\n  (:start . 165) (:id . 64))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 187) (:start . 183)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cap") (:form . "cap") (:end . 195) (:start . 192)\n  (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 200) (:start . 196)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 213)\n  (:start . 208) (:id . 72))\n ((:tag . "JJ") (:stem . "granulocyte/macrophage")\n  (:form . "granulocyte/macrophage") (:end . 236) (:start . 214) (:id . 73))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 255) (:start . 237) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 262)\n  (:start . 256) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 267) (:start . 263)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 271) (:start . 268)\n  (:id . 77))\n ((:tag . "JJ") (:stem . 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"IL-4") (:end . 327) (:start . 323)\n  (:id . 88))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 332) (:start . 328)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 333) (:start . 332)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s120.6) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001100@unknown@formal@none@1@S@The plasmids carrying multiple copies of the P sequence showed higher responsiveness to the stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 37) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 62) (:start . 56)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 69) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 84) (:start . 70) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s120.8) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001101@unknown@formal@none@1@S@The binding protein ( s ) that recognize the P sequence of the IL-4 gene were identified by DNA-mobility-shift assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 11) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 40)\n  (:start . 31) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 88)\n  (:start . 78) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dna-mobility-shift") (:form . "DNA-mobility-shift")\n  (:end . 110) (:start . 92) (:id . 60))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s120.9) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001102@unknown@formal@none@1@S@The binding of NF(P) (a DNA binding protein that specifically recognizes the P sequence) to the P sequence was abolished when oligonucleotides carrying base substitutions were used, indicating that the NF(P) interaction is sequence-specific and that binding specificity of the protein paralleled the sequence requirements for IL-4 expression in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . 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"sequence-specific")\n  (:end . 240) (:start . 223) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 244) (:start . 241)\n  (:id . 79))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 249) (:start . 245)\n  (:id . 80))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 257)\n  (:start . 250) (:id . 81))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 269)\n  (:start . 258) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 272) (:start . 270)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 276) (:start . 273)\n  (:id . 84))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 284)\n  (:start . 277) (:id . 85))\n ((:tag . "VBD") (:stem . "parallel") (:form . "paralleled") (:end . 295)\n  (:start . 285) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 299) (:start . 296)\n  (:id . 87))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 308)\n  (:start . 300) (:id . 88))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 321)\n  (:start . 309) (:id . 89))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 325) (:start . 322)\n  (:id . 90))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 330) (:start . 326)\n  (:id . 91))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 341)\n  (:start . 331) (:id . 92))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 344) (:start . 342)\n  (:id . 93))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 349) (:start . 345)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 350) (:start . 349)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x120.10.1) (:span 182 197)))\n (:hscopes ((:id . :x120.10.1) (:span 182 349)))\n (:identifiers (:sid . :s120.10) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001103@unknown@formal@none@1@S@The P sequence does not share homology with the 5' upstream sequence of the IL-2 gene, even though surrounding sequences of the IL-4 gene share high homology with the IL-2 gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "share") (:form . "share") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 98)\n  (:start . 92) (:id . 61))\n ((:tag . "VBG") (:stem . "surround") (:form . "surrounding") (:end . 110)\n  (:start . 99) (:id . 62))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 120)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "share") (:form . "share") (:end . 143)\n  (:start . 138) (:id . 68))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 148) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 157)\n  (:start . 149) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 171) (:start . 167)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 176) (:start . 172)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x120.11.1) (:span 20 23)))\n (:nscopes ((:id . :x120.11.1) (:span 20 85)))\n (:identifiers (:sid . :s120.11) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001104@unknown@formal@none@1@S@We conclude that a different set of proteins recognize IL-2 and IL-4 genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s120.12) (:did . :|92212930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001105@unknown@formal@none@1@S@Glucocorticoid receptor binding in three different cell types in major depressive disorder: lack of evidence of receptor binding defect.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "depressive") (:form . "depressive") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x121.1.1) (:span 92 96)))\n (:nscopes ((:id . :x121.1.1) (:span 92 135)))\n (:identifiers (:sid . :s121.1) (:did . :|92213189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001106@unknown@formal@none@1@S@1 . In order to further understand the apparent glucocorticoid resistance in major depressive disorder, circadian variation in cortisol concentration, dexamethasone suppression and glucocorticoid receptor binding in mononuclear leukocytes, polymorphonuclear leukocytes and cultured skin fibroblasts were measured in rigidly defined major depressive disorder patients and non-depressed psychiatric controls.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 6) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 12) (:start . 7)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 23)\n  (:start . 16) (:id . 47))\n ((:tag . "VB") (:stem . 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"culture") (:form . "cultured") (:end . 281)\n  (:start . 273) (:id . 77))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 286) (:start . 282)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 298)\n  (:start . 287) (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 303) (:start . 299)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 312)\n  (:start . 304) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 315) (:start . 313)\n  (:id . 82))\n ((:tag . "RB") (:stem . "rigidly") (:form . "rigidly") (:end . 323)\n  (:start . 316) (:id . 83))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 331)\n  (:start . 324) (:id . 84))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 337)\n  (:start . 332) (:id . 85))\n ((:tag . "JJ") (:stem . "depressive") (:form . "depressive") (:end . 348)\n  (:start . 338) (:id . 86))\n ((:tag . "NN") (:stem . 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5001107@unknown@formal@none@1@S@2 . Mononuclear leukocytes binding to glucocorticoid correlated significantly with polymorphonuclear leukocytes binding to glucocorticoid, but both determinations failed to differentiate major depressive disorder and control subjects.@(((:tag . "LS") (:stem . "2") (:form . "2") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "Mononuclear") (:end . 15)\n  (:start . 4) (:id . 44))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 52) (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 77) (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 100) (:start . 83) (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 111)\n  (:start . 101) (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 55))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 137) (:start . 123) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 142) (:start . 139)\n  (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 147) (:start . 143)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "determination") (:form . "determinations")\n  (:end . 162) (:start . 148) (:id . 60))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 169)\n  (:start . 163) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 62))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 186) (:start . 173) (:id . 63))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 192)\n  (:start . 187) (:id . 64))\n ((:tag . "JJ") (:stem . "depressive") (:form . "depressive") (:end . 203)\n  (:start . 193) (:id . 65))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 212)\n  (:start . 204) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 67))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 224)\n  (:start . 217) (:id . 68))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 233)\n  (:start . 225) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s121.3) (:did . :|92213189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001108@unknown@formal@none@1@S@3 . Initial and post-dexamethasone in vitro fibroblast binding to glucocorticoid was not different between major depressive disorder and non-depressed control subjects.@(((:tag . "LS") (:stem . "3") (:form . "3") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "initial") (:form . "Initial") (:end . 11)\n  (:start . 4) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "post-dexamethasone") (:form . "post-dexamethasone")\n  (:end . 34) (:start . 16) (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 80) (:start . 66) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "JJ") (:stem . "depressive") (:form . "depressive") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "non-depressed") (:form . "non-depressed")\n  (:end . 150) (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 158)\n  (:start . 151) (:id . 62))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 167)\n  (:start . 159) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x121.4.1) (:span 85 88)))\n (:nscopes ((:id . :x121.4.1) (:span 85 167)))\n (:identifiers (:sid . :s121.4) (:did . :|92213189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001110@unknown@formal@none@1@S@Kinetics of nuclear translocation and turnover of the vitamin D receptor in human HL60 leukemia cells and peripheral blood lymphocytes-- coincident rise of DNA-relaxing activity in nuclear extracts.@(((:tag . "NNP") (:stem . "Kinetic") (:form . "Kinetics") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes–") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "coincident") (:form . "coincident") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "dna-relaxing") (:form . "DNA-relaxing") (:end . 168)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 197)\n  (:start . 189) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s122.1) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001111@unknown@formal@none@1@S@High affinity receptors (VDR) for 1,25-dihydroxycholecalciferol (calcitriol) are expressed in HL60 human leukemia cells and in low numbers in peripheral blood lymphocytes (PBL).@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "1,25-dihydroxycholecalciferol")\n  (:form . "1,25-dihydroxycholecalciferol") (:end . 63) (:start . 34)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 152)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 170)\n  (:start . 159) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s122.2) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001112@unknown@formal@none@1@S@HL60 cells, expressing some characteristics of promyelocytes, can be induced to monocytoid differentiation by calcitriol.@(((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 43) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "promyelocyte") (:form . "promyelocytes")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 106) (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s122.3) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001113@unknown@formal@none@1@S@Specific nuclear translocation of [3H]calcitriol/VDR was examined after exposure of whole cells to 10(-9) M/l calcitriol in the presence and absence of a 500-fold excess of unlabeled ligand and subsequent isolation of nuclei.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "3H]calcitriol/VDR") (:form . "3H]calcitriol/VDR")\n  (:end . 52) (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "10(-9)") (:form . "10(-9)") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "NNP") (:stem . "M/l") (:form . "M/l") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "500-fold") (:form . "500-fold") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "excess") (:form . "excess") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "unlabeled") (:form . "unlabeled") (:end . 182)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 189)\n  (:start . 183) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 204)\n  (:start . 194) (:id . 72))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 214)\n  (:start . 205) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 224)\n  (:start . 218) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s122.4) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001114@unknown@formal@none@1@S@Specific nuclear translocation of [3H]calcitriol/VDR was found to be time dependent reaching a maximum of approximately 2100 binding sites/nucleus after 3 h of incubation in HL60 cells, whereas a maximum of approximately 310 binding sites/nucleus was found after 3 h in PBL.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "3H]calcitriol/VDR") (:form . "3H]calcitriol/VDR")\n  (:end . 52) (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBG") (:stem . "reach") (:form . "reaching") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 119) (:start . 106) (:id . 58))\n ((:tag . "CD") (:stem . "2100") (:form . "2100") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "sites/nucleu") (:form . "sites/nucleus")\n  (:end . 146) (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 154) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 184)\n  (:start . 179) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 193)\n  (:start . 186) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 195) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 203)\n  (:start . 196) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 220) (:start . 207) (:id . 75))\n ((:tag . "CD") (:stem . "310") (:form . "310") (:end . 224) (:start . 221)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 232)\n  (:start . 225) (:id . 77))\n ((:tag . "NN") (:stem . "sites/nucleus") (:form . "sites/nucleus")\n  (:end . 246) (:start . 233) (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 250) (:start . 247)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 256)\n  (:start . 251) (:id . 80))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 262)\n  (:start . 257) (:id . 81))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 264) (:start . 263)\n  (:id . 82))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 266) (:start . 265)\n  (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 269) (:start . 267)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 273) (:start . 270)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s122.5) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001115@unknown@formal@none@1@S@Pulse exposure of HL60 to radiolabeled hormone for 3 h followed by culture in medium without serum and calcitriol lead to nuclear retention of approximately 1600 radiolabeled VDR by 8 h and approximately 1000 VDR by 24 h.@(((:tag . "NN") (:stem . "pulse") (:form . "Pulse") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "radiolabele") (:form . "radiolabeled") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "retention") (:form . "retention") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 156) (:start . 143) (:id . 66))\n ((:tag . "CD") (:stem . "1600") (:form . "1600") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "radiolabele") (:form . "radiolabeled") (:end . 174)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "vdr") (:form . "VDR") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 185) (:start . 184)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 203) (:start . 190) (:id . 74))\n ((:tag . "CD") (:stem . "1000") (:form . "1000") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "NN") (:stem . "vdr") (:form . "VDR") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 215) (:start . 213)\n  (:id . 77))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 218) (:start . 216)\n  (:id . 78))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 220) (:start . 219)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x122.6.1) (:span 85 92)))\n (:nscopes ((:id . :x122.6.1) (:span 85 113)))\n (:identifiers (:sid . :s122.6) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001116@unknown@formal@none@1@S@Radiolabeled VDR disappeared from the nuclear compartment with a halflife of approximately 30 min if cells were cultured with identical concentrations of unlabeled hormone after the pulse (pulse/chase-experiments).@(((:tag . "VBN") (:stem . "radiolabele") (:form . "Radiolabeled") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "disappear") (:form . "disappeared") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "halflife") (:form . "halflife") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 150) (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unlabeled") (:form . "unlabeled") (:end . 163)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 171)\n  (:start . 164) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 177)\n  (:start . 172) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pulse") (:form . "pulse") (:end . 187)\n  (:start . 182) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "pulse/chase-experiment")\n  (:form . "pulse/chase-experiments") (:end . 212) (:start . 189) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s122.7) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001117@unknown@formal@none@1@S@No difference of VDR retention in pulse and pulse/chase-experiments was seen in PBL, where VDR halflife was approximately 30 min.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "retention") (:form . "retention") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pulse") (:form . "pulse") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "pulse/chase-experiment")\n  (:form . "pulse/chase-experiments") (:end . 67) (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "halflife") (:form . "halflife") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 121) (:start . 108) (:id . 60))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x122.8.1) (:span 0 2)))\n (:nscopes ((:id . :x122.8.1) (:span 0 83)))\n (:identifiers (:sid . :s122.8) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001118@unknown@formal@none@1@S@No specific translocation into the nuclear compartment was seen when isolated nuclei were incubated in [3H]calcitriol.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "3H]calcitriol") (:form . "3H]calcitriol")\n  (:end . 117) (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x122.9.1) (:span 0 2)))\n (:nscopes ((:id . :x122.9.1) (:span 0 117)))\n (:identifiers (:sid . :s122.9) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001120@unknown@formal@none@1@S@The activity of DNA relaxing enzymes (e.g.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "relaxing") (:form . "relaxing") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "e.g") (:form . "e.g") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s122.11) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001121@unknown@formal@none@1@S@topoisomerases I and II) in nuclear extracts was measured using a PBR 322-relaxation-assay.@(((:tag . "NNS") (:stem . "topoisomeras") (:form . "topoisomerases")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pbr") (:form . "PBR") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "322-relaxation-assay")\n  (:form . "322-relaxation-assay") (:end . 90) (:start . 70) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s122.12) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001122@unknown@formal@none@1@S@Enhanced overall enzyme activity was found in nuclear extracts by 1 h after incubation with calcitriol (final ethanol concentration 0.0001 % v/v) in HL60 and PBL.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 131) (:start . 118) (:id . 61))\n ((:tag . "CD") (:stem . "0.0001") (:form . "0.0001") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "v/v") (:form . "v/v") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s122.13) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001123@unknown@formal@none@1@S@The enhanced activity disappeared after 2 h in PBL, whereas it was still enhanced by 4 h in HL60.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "disappear") (:form . "disappeared") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s122.14) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001124@unknown@formal@none@1@S@No effect was seen in ethanol treated controls.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x122.15.1) (:span 0 2)))\n (:nscopes ((:id . :x122.15.1) (:span 0 46)))\n (:identifiers (:sid . :s122.15) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001125@unknown@formal@none@1@S@We conclude that a specific nuclear translocation mechanism exists for calcitriol in both cell types examined, most likely due to translocation of receptor proteins after hormone binding.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 143) (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 186)\n  (:start . 179) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x122.16.1) (:span 116 122)))\n (:hscopes ((:id . :x122.16.1) (:span 116 186)))\n (:identifiers (:sid . :s122.16) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001126@unknown@formal@none@1@S@Translocated hormone/receptor complexes compete for a limited number of specific nuclear binding sites.@(((:tag . "VBN") (:stem . "translocate") (:form . "Translocated") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hormone/receptor") (:form . "hormone/receptor")\n  (:end . 29) (:start . 13) (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 39)\n  (:start . 30) (:id . 44))\n ((:tag . "VBP") (:stem . "compete") (:form . "compete") (:end . 47)\n  (:start . 40) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s122.17) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001127@unknown@formal@none@1@S@Enhanced activity of topoisomerases in nuclear extracts upon translocation of VDR might reflect interaction of both within the nuclear compartment, thus initiating DNA-unwinding, a prerequisite of transcription initiation.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "topoisomeras") (:form . "topoisomerases")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 107)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 146)\n  (:start . 135) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "initiate") (:form . "initiating") (:end . 163)\n  (:start . 153) (:id . 64))\n ((:tag . "NNP") (:stem . "DNA-unwinding") (:form . "DNA-unwinding")\n  (:end . 177) (:start . 164) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "prerequisite") (:form . "prerequisite") (:end . 193)\n  (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 210) (:start . 197) (:id . 70))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 221)\n  (:start . 211) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x122.18.1) (:span 82 87)))\n (:hscopes ((:id . :x122.18.1) (:span 82 221)))\n (:identifiers (:sid . :s122.18) (:did . :|92215726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001128@unknown@formal@none@1@S@The B cell-specific nuclear factor OTF-2 positively regulates transcription of the human class II transplantation gene, DRA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 19) (:start . 6) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 113) (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s123.1) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001130@unknown@formal@none@1@S@Several DNA-binding proteins are known to bind this sequence.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s123.3) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001131@unknown@formal@none@1@S@The best characterized are the B cell-specific OTF-2 and the ubiquitous OTF-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s123.4) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001132@unknown@formal@none@1@S@This report directly demonstrates that OTF-2 but not OTF-1 regulates the DRA gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x123.5.1) (:span 49 52)))\n (:nscopes ((:id . :x123.5.1) (:span 49 58)))\n (:identifiers (:sid . :s123.5) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001133@unknown@formal@none@1@S@In vitro transcription analysis using protein fractions enriched for the octamer-binding protein OTF-2 demonstrate a positive functional role for OTF-2 in DRA gene transcription.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 88) (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 114)\n  (:start . 103) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 136)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 60))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 151)\n  (:start . 146) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 177) (:start . 164) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s123.6) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001134@unknown@formal@none@1@S@In contrast, OTF-1-enriched protein fractions did not affect DRA gene transcription although it functionally enhanced the transcription of another gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "otf-1-enriched") (:form . "OTF-1-enriched")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 146)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x123.7.1) (:span 50 53)))\n (:nscopes ((:id . :x123.7.1) (:span 50 83)))\n (:identifiers (:sid . :s123.7) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001135@unknown@formal@none@1@S@Recombinant OTF-2 protein produced by in vitro transcription/translation could also enhance DRA gene transcription in vitro.@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription/translation")\n  (:form . "transcription/translation") (:end . 72) (:start . 47) (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 78) (:start . 73)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 83) (:start . 79)\n  (:id . 51))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x123.8.1) (:span 73 78)))\n (:hscopes ((:id . :x123.8.1) (:span 73 123)))\n (:identifiers (:sid . :s123.8) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001136@unknown@formal@none@1@S@In vivo transient transfection studies utilizing an OTF-2 expression vector resulted in similar findings : that OTF-2 protein enhanced DRA gene transcription, and that this effect requires an intact octamer element.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "VBG") (:stem . "utilize") (:form . "utilizing") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 167) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 179)\n  (:start . 173) (:id . 68))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 188)\n  (:start . 180) (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 198)\n  (:start . 192) (:id . 71))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 206)\n  (:start . 199) (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 214)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s123.9) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001137@unknown@formal@none@1@S@Together these results constitute the first direct evidence of a positive role for the lymphoid-specific octamer-binding factor in DRA gene transcription.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 104) (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 120) (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s123.10) (:did . :|92218428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001138@unknown@formal@none@1@S@[Regulation of intracellular cholesterol synthesis in hypercholesterolemia by glucocorticoids]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 11)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypercholesterolemia")\n  (:form . "hypercholesterolemia") (:end . 74) (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 93) (:start . 78) (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 94) (:start . 93)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s124.1) (:did . :|92223210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001140@unknown@formal@none@1@S@The cells of hyperlipidemic patients had lowered levels of glucocorticoid receptors concomitantly with a partial loss of their sensitivity to glucocorticoids.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hyperlipidemic") (:form . "hyperlipidemic")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "lower") (:form . "lowered") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 73) (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 97) (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 157) (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s124.3) (:did . :|92223210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001141@unknown@formal@none@1@S@In fibroblasts from patients with hereditary hypercholesteremia of homozygous type the number of glucocorticoid receptors did not exceed 10 % of their content in normal cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hereditary") (:form . "hereditary") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "hypercholesteremia") (:form . "hypercholesteremia")\n  (:end . 63) (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 111) (:start . 97) (:id . 55))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 121)\n  (:start . 112) (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 125) (:start . 122)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 129) (:start . 126)\n  (:id . 58))\n ((:tag . "VB") (:stem . "exceed") (:form . "exceed") (:end . 136)\n  (:start . 130) (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 168)\n  (:start . 162) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x124.4.1) (:span 126 129)))\n (:nscopes ((:id . :x124.4.1) (:span 126 174)))\n (:identifiers (:sid . :s124.4) (:did . :|92223210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001142@unknown@formal@none@1@S@The decrease of the number of glucocorticoid receptors in patients with type IIa hyperlipidemia seems to be a compensatory response of cells culminating in activation of endogenous cholesterol synthesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IIa") (:form . "IIa") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hyperlipidemia") (:form . "hyperlipidemia")\n  (:end . 95) (:start . 81) (:id . 55))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "compensatory") (:form . "compensatory") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "VBG") (:stem . "culminate") (:form . "culminating") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 166)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 192)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 202)\n  (:start . 193) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x124.5.1) (:span 96 101)))\n (:hscopes ((:id . :x124.5.1) (:span 0 202)))\n (:identifiers (:sid . :s124.5) (:did . :|92223210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001143@unknown@formal@none@1@S@Transcription factor activation and functional stimulation of human monocytes.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 58)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s125.1) (:did . :|92224250|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001144@unknown@formal@none@1@S@Activation of expression of genes encoding transcription factors: c-fos and c-jun and formation of AP1 transcriptional complex in human monocytes was investigated.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 118) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 162)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s125.2) (:did . :|92224250|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001145@unknown@formal@none@1@S@It was found that lipopolysaccharide induced strongly both c-fos and c-jun expression as well as AP1 formation.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 36) (:start . 18) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s125.3) (:did . :|92224250|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001146@unknown@formal@none@1@S@Interferon gamma activated strongly c-fos and weakly c-jun and AP1.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferon") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s125.4) (:did . :|92224250|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001147@unknown@formal@none@1@S@Tumor necrosis factor induced slightly c-fos and had almost no effect on c-jun and AP1.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s125.5) (:did . :|92224250|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001148@unknown@formal@none@1@S@The data suggest that differences in functional responses elicited in monocytes by all three factors may be dependent on different routes on nuclear signalling employed by the factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "route") (:form . "routes") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 159)\n  (:start . 149) (:id . 65))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x125.6.1) (:span 101 104)) ((:id . :x125.6.2) (:span 9 16)))\n (:hscopes ((:id . :x125.6.1) (:span 101 183))\n  ((:id . :x125.6.2) (:span 9 183)))\n (:identifiers (:sid . :s125.6) (:did . :|92224250|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001150@unknown@formal@none@1@S@Plasma cortisol and aldosterone levels and number of related receptors in mononuclear leukocytes were measured in 49 healthy aged subjects (62-97 yr) and in 21 adult controls (21-50 yr).@(((:tag . "NN") (:stem . "plasma") (:form . "Plasma") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "CD") (:stem . "49") (:form . "49") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "CD") (:stem . "62-97") (:form . "62-97") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "yr") (:form . "yr") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 174)\n  (:start . 166) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "CD") (:stem . "21-50") (:form . "21-50") (:end . 181)\n  (:start . 176) (:id . 72))\n ((:tag . "NN") (:stem . "yr") (:form . "yr") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s126.2) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001151@unknown@formal@none@1@S@In all subjects, in addition, lymphocyte subsets were determined as an index of corticosteroid action.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "index") (:form . "index") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 94) (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s126.3) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001152@unknown@formal@none@1@S@The mean number of type I and type II receptors was significantly lower in aged subjects than in controls (respectively, 198 ± 96 and 272 ± 97 receptors/cell for type I, and 1,794 ± 803 and 3,339 ± 918 for type II receptors).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 65) (:start . 52) (:id . 53))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 119)\n  (:start . 107) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "CD") (:stem . "198") (:form . "198") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "CD") (:stem . "96") (:form . "96") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 67))\n ((:tag . "CD") (:stem . "272") (:form . "272") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 139) (:start . 138)\n  (:id . 69))\n ((:tag . "CD") (:stem . "97") (:form . "97") (:end . 142) (:start . 140)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "receptors/cell") (:form . "receptors/cell")\n  (:end . 157) (:start . 143) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 161) (:start . 158)\n  (:id . 72))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 166) (:start . 162)\n  (:id . 73))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 168) (:start . 167)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 76))\n ((:tag . "CD") (:stem . "1,794") (:form . "1,794") (:end . 179)\n  (:start . 174) (:id . 77))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 181) (:start . 180)\n  (:id . 78))\n ((:tag . "CD") (:stem . "803") (:form . "803") (:end . 185) (:start . 182)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 80))\n ((:tag . "CD") (:stem . "3,339") (:form . "3,339") (:end . 195)\n  (:start . 190) (:id . 81))\n ((:tag . "IN") (:stem . "±") (:form . "±") (:end . 197) (:start . 196)\n  (:id . 82))\n ((:tag . "CD") (:stem . "918") (:form . "918") (:end . 201) (:start . 198)\n  (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 205) (:start . 202)\n  (:id . 84))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 210) (:start . 206)\n  (:id . 85))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 213) (:start . 211)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 223)\n  (:start . 214) (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s126.4) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001153@unknown@formal@none@1@S@Plasma aldosterone and cortisol and lymphocyte subsets were not different in the two groups.@(((:tag . "NN") (:stem . "plasma") (:form . "Plasma") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x126.5.1) (:span 60 63)))\n (:nscopes ((:id . :x126.5.1) (:span 60 91)))\n (:identifiers (:sid . :s126.5) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001154@unknown@formal@none@1@S@All of the parameters were also tested for correlation, and a significant inverse correlation was found between age and type I and type II receptors when all subjects were plotted and between aged and CD4 and age and CD4/CD8 in the aged group.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 38) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 73)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "plot") (:form . "plotted") (:end . 179)\n  (:start . 172) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 191)\n  (:start . 184) (:id . 74))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 204) (:start . 201)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 78))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 212) (:start . 209)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cd4/cd8") (:form . "CD4/CD8") (:end . 224)\n  (:start . 217) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 236) (:start . 232)\n  (:id . 84))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 242)\n  (:start . 237) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s126.6) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001155@unknown@formal@none@1@S@These data show that aged subjects have reductions of corticosteroid receptors that are not associated with increase of related steroids and that this situation probably represents a concomitant of the normal aging process.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "reduction") (:form . "reductions") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 68) (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "steroid") (:form . "steroids") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "situation") (:form . "situation") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 169)\n  (:start . 161) (:id . 66))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 182) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "concomitant") (:form . "concomitant") (:end . 194)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 208)\n  (:start . 202) (:id . 72))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 222)\n  (:start . 215) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x126.7.1) (:span 161 169)))\n (:ncues ((:id . :x126.7.2) (:span 88 91)))\n (:hscopes ((:id . :x126.7.1) (:span 161 222)))\n (:nscopes ((:id . :x126.7.2) (:span 88 136)))\n (:identifiers (:sid . :s126.7) (:did . :|92230800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001156@unknown@formal@none@1@S@Stable expression of HB24, a diverged human homeobox gene, in T lymphocytes induces genes involved in T cell activation and growth.@(((:tag . "JJ") (:stem . "stable") (:form . "Stable") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HB24") (:form . "HB24") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 75)\n  (:start . 64) (:id . 55))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s127.1) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001157@unknown@formal@none@1@S@A diverged homeobox gene, HB24, which is known to be induced following lymphocyte activation, was introduced into Jurkat T cells under the control of a constitutive promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HB24") (:form . "HB24") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 60)\n  (:start . 53) (:id . 54))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 70)\n  (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 120)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 164)\n  (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 173)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s127.2) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001158@unknown@formal@none@1@S@Stable transfectants of HB24 were established that expressed high levels of HB24 mRNA and possessed an altered phenotype suggestive of activated T cells.@(((:tag . "JJ") (:stem . "stable") (:form . "Stable") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 20) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HB24") (:form . "HB24") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "possess") (:form . "possessed") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "suggestive") (:form . "suggestive") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x127.3.1) (:span 121 131)))\n (:hscopes ((:id . :x127.3.1) (:span 121 152)))\n (:identifiers (:sid . :s127.3) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001160@unknown@formal@none@1@S@Analysis of IL-2R alpha expression by transient transfection of IL-2R alpha promoter constructs into the HB24 transfectants revealed constitutive expression (about 60% of phytohemagglutinin- and phorbol ester-activated Jurkat cells) that was dependent on the kappa B site in the IL-2R alpha promoter.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 145)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 62))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 163)\n  (:start . 158) (:id . 63))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "phytohemagglutinin-")\n  (:form . "phytohemagglutinin-") (:end . 190) (:start . 171) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 68))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 202)\n  (:start . 195) (:id . 69))\n ((:tag . "JJ") (:stem . "ester-activated") (:form . "ester-activated")\n  (:end . 218) (:start . 203) (:id . 70))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 225)\n  (:start . 219) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 231)\n  (:start . 226) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 237) (:start . 233)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 241) (:start . 238)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 251)\n  (:start . 242) (:id . 76))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 254) (:start . 252)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 258) (:start . 255)\n  (:id . 78))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 264)\n  (:start . 259) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 266) (:start . 265)\n  (:id . 80))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 271) (:start . 267)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 274) (:start . 272)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 278) (:start . 275)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 284)\n  (:start . 279) (:id . 84))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 290)\n  (:start . 285) (:id . 85))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 299)\n  (:start . 291) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 300) (:start . 299)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s127.5) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001161@unknown@formal@none@1@S@Furthermore, as a consequence of the increased HB24 mRNA levels, the Jurkat HB24 transfectants proliferated more rapidly than control cell lines.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 94) (:start . 81) (:id . 57))\n ((:tag . "VBD") (:stem . "proliferate") (:form . "proliferated") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s127.6) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001162@unknown@formal@none@1@S@Thus, stable expression of HB24 confers an activation phenotype on a human T cell line, implicating this gene as an important transcriptional factor during T cell activation and growth.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hb24") (:form . "HB24") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 99)\n  (:start . 88) (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 125)\n  (:start . 116) (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 141) (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 155)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 184)\n  (:start . 178) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s127.7) (:did . :|92235036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001163@unknown@formal@none@1@S@Studies on the biological activity of triiodothyronine sulfate.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "triiodothyronine") (:form . "triiodothyronine")\n  (:end . 54) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "sulfate") (:form . "sulfate") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s128.1) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001164@unknown@formal@none@1@S@Hepatic microsomes and isolated hepatocytes in short term culture desulfate T3 sulfate (T3SO4).@(((:tag . "JJ") (:stem . "hepatic") (:form . "Hepatic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "microsome") (:form . "microsomes") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "hepatocyte") (:form . "hepatocytes") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "desulfate") (:form . "desulfate") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sulfate") (:form . "sulfate") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t3so4") (:form . "T3SO4") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s128.2) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001165@unknown@formal@none@1@S@We, therefore, wished to determine whether T3SO4 could mimic the action of thyroid hormone in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 13)\n  (:start . 4) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "wish") (:form . "wished") (:end . 21) (:start . 15)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "t3so4") (:form . "T3SO4") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x128.3.1) (:span 49 54)) ((:id . :x128.3.2) (:span 35 42)))\n (:hscopes ((:id . :x128.3.1) (:span 49 99))\n  ((:id . :x128.3.2) (:span 35 99)))\n (:identifiers (:sid . :s128.3) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001166@unknown@formal@none@1@S@T3SO4 had no thyromimetic effect on the activity of Ca(2+)-ATPase in human erythrocyte membranes at doses up to 10,000 times the maximally effective dose of T3 (10(-10) mol/L).@(((:tag . "NNP") (:stem . "T3SO4") (:form . "T3SO4") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "thyromimetic") (:form . "thyromimetic") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ca(2+)-ATPase") (:form . "Ca(2+)-ATPase")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10,000") (:form . "10,000") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "RB") (:stem . "maximally") (:form . "maximally") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "10(-10)") (:form . "10(-10)") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 174)\n  (:start . 169) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x128.4.1) (:span 10 12)))\n (:nscopes ((:id . :x128.4.1) (:span 10 32)))\n (:identifiers (:sid . :s128.4) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001167@unknown@formal@none@1@S@In GH4C1 pituitary cells, T3SO4 failed to displace [125I]T3 from nuclear receptors in intact cells or soluble preparations.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gh4c1") (:form . "GH4C1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "T3SO4") (:form . "T3SO4") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 38) (:start . 32)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "displace") (:form . "displace") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "125I]T3") (:form . "125I]T3") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "preparation") (:form . "preparations") (:end . 122)\n  (:start . 110) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s128.5) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001168@unknown@formal@none@1@S@Thus, T3SO4 was not directly thyromimetic in either an isolated human membrane system or a pituitary cell system in which nuclear receptor occupancy correlates with GH synthesis.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "T3SO4") (:form . "T3SO4") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "JJ") (:stem . "thyromimetic") (:form . "thyromimetic") (:end . 41)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 159)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 177)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x128.6.1) (:span 16 19)))\n (:nscopes ((:id . :x128.6.1) (:span 16 112)))\n (:identifiers (:sid . :s128.6) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001170@unknown@formal@none@1@S@Human fibroblasts contained roughly the same level of microsomal p-nitrophenyl sulfatase activity as that previously observed in hepatic microsomes.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "RB") (:stem . "roughly") (:form . "roughly") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "microsomal") (:form . "microsomal") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "p-nitrophenyl") (:form . "p-nitrophenyl")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "sulfatase") (:form . "sulfatase") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 136)\n  (:start . 129) (:id . 59))\n ((:tag . "NNS") (:stem . "microsome") (:form . "microsomes") (:end . 147)\n  (:start . 137) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s128.8) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001171@unknown@formal@none@1@S@Propylthiouracil (50 mumol/L) did not affect the action of T3SO4, suggesting that deiodination was not important for this activity of T3SO4.@(((:tag . "NNP") (:stem . "Propylthiouracil") (:form . "Propylthiouracil")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mumol/l") (:form . "mumol/L") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t3so4") (:form . "T3SO4") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "deiodination") (:form . "deiodination") (:end . 94)\n  (:start . 82) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t3so4") (:form . "T3SO4") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x128.9.2) (:span 66 76)))\n (:ncues ((:id . :x128.9.1) (:span 99 102)) ((:id . :x128.9.3) (:span 34 37)))\n (:hscopes ((:id . :x128.9.2) (:span 66 139)))\n (:nscopes ((:id . :x128.9.1) (:span 99 139))\n  ((:id . :x128.9.3) (:span 34 64)))\n (:identifiers (:sid . :s128.9) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001172@unknown@formal@none@1@S@Thus, it appears  T3SO4 has no intrinsic biological activity, but , under certain circumstances, may be reactivated by desulfation.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "t3so4") (:form . "T3SO4") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 40)\n  (:start . 31) (:id . 49))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 95) (:start . 82) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "reactivate") (:form . "reactivated") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "desulfation") (:form . "desulfation") (:end . 130)\n  (:start . 119) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x128.10.1) (:span 97 100))\n  ((:id . :x128.10.3) (:span 9 16)))\n (:ncues ((:id . :x128.10.2) (:span 28 30)))\n (:hscopes ((:id . :x128.10.1) (:span 97 130))\n  ((:id . :x128.10.3) (:span 9 130)))\n (:nscopes ((:id . :x128.10.2) (:span 28 60)))\n (:identifiers (:sid . :s128.10) (:did . :|92235212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001173@unknown@formal@none@1@S@Nuclear factor of activated T cells contains Fos and Jun.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s129.1) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001174@unknown@formal@none@1@S@The nuclear factor NF-AT (ref. 1) is induced in T cells stimulated through the T-cell receptor/CD3 complex, and is required for interleukin-2 (IL-2) gene induction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ref.") (:form . "ref.") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 66)\n  (:start . 56) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 74)\n  (:start . 67) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 85)\n  (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "receptor/cd3") (:form . "receptor/CD3") (:end . 98)\n  (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 123)\n  (:start . 115) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 141) (:start . 128) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 153) (:start . 149)\n  (:id . 70))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 163)\n  (:start . 154) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s129.2) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001175@unknown@formal@none@1@S@Although NF-AT has not been cloned or purified, there is evidence that it is a major target for immunosuppression by cyclosporin A (CsA) and FK506 (refs 2-7).@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 91)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 113) (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 128)\n  (:start . 117) (:id . 63))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 146)\n  (:start . 141) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "ref") (:form . "refs") (:end . 152) (:start . 148)\n  (:id . 71))\n ((:tag . "CD") (:stem . "2-7") (:form . "2-7") (:end . 156) (:start . 153)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x129.3.1) (:span 35 37)))\n (:ncues ((:id . :x129.3.2) (:span 19 22)))\n (:hscopes ((:id . :x129.3.1) (:span 28 46)))\n (:nscopes ((:id . :x129.3.2) (:span 9 46)))\n (:identifiers (:sid . :s129.3) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001176@unknown@formal@none@1@S@NF-AT induction may require two activation-dependent events: the CsA-sensitive translocation of a pre-existing component and the CsA-resistant synthesis of a nuclear component.@(((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 52) (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 92) (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pre-existing") (:form . "pre-existing") (:end . 110)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 120)\n  (:start . 111) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "csa-resistant") (:form . "CsA-resistant")\n  (:end . 142) (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 152)\n  (:start . 143) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 165)\n  (:start . 158) (:id . 63))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 175)\n  (:start . 166) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x129.4.1) (:span 16 19)))\n (:hscopes ((:id . :x129.4.1) (:span 16 175)))\n (:identifiers (:sid . :s129.4) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001177@unknown@formal@none@1@S@Here we report that the newly synthesized nuclear component of NF-AT is the transcription factor AP-1.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s129.5) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001178@unknown@formal@none@1@S@We show that the inducible nuclear form of NF-AT contains Fos and Jun proteins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s129.6) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001180@unknown@formal@none@1@S@On the basis of binding, reconstitution and cotransfection experiments, we propose that activation of NF-AT occurs in at least two stages: a CsA-sensitive stage involving modification and/or translocation of the pre-existing NF-AT complex, and a CsA-insensitive stage involving the addition of newly synthesized Fos or Fos/Jun proteins to the pre-existing complex.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reconstitution") (:form . "reconstitution")\n  (:end . 39) (:start . 25) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 58) (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 154) (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 170)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 183)\n  (:start . 171) (:id . 70))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 190)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 204) (:start . 191) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "pre-existing") (:form . "pre-existing") (:end . 224)\n  (:start . 212) (:id . 75))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 230)\n  (:start . 225) (:id . 76))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 238)\n  (:start . 231) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 245) (:start . 244)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "csa-insensitive") (:form . "CsA-insensitive")\n  (:end . 261) (:start . 246) (:id . 81))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 267)\n  (:start . 262) (:id . 82))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 277)\n  (:start . 268) (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 281) (:start . 278)\n  (:id . 84))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 290)\n  (:start . 282) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 293) (:start . 291)\n  (:id . 86))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 299)\n  (:start . 294) (:id . 87))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 311)\n  (:start . 300) (:id . 88))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 315) (:start . 312)\n  (:id . 89))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 318) (:start . 316)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "Fos/Jun") (:form . "Fos/Jun") (:end . 326)\n  (:start . 319) (:id . 91))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 335)\n  (:start . 327) (:id . 92))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 338) (:start . 336)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 342) (:start . 339)\n  (:id . 94))\n ((:tag . "JJ") (:stem . "pre-existing") (:form . "pre-existing") (:end . 355)\n  (:start . 343) (:id . 95))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 363)\n  (:start . 356) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 364) (:start . 363)\n  (:id . 97)))@@@1@56@((:hcues ((:id . :x129.8.1) (:span 316 318))\n  ((:id . :x129.8.2) (:span 184 190)) ((:id . :x129.8.3) (:span 75 82)))\n (:hscopes ((:id . :x129.8.1) (:span 312 326))\n  ((:id . :x129.8.2) (:span 171 204)) ((:id . :x129.8.3) (:span 75 363)))\n (:identifiers (:sid . :s129.8) (:did . :|92244343|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001181@unknown@formal@none@1@S@Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.@(((:tag . "NNP") (:stem . "Interferon-gamma") (:form . "Interferon-gamma")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 28)\n  (:start . 17) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 42)\n  (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 51)\n  (:start . 43) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "interferon-stimulated")\n  (:form . "interferon-stimulated") (:end . 95) (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 101) (:start . 96)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 109)\n  (:start . 102) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interferon-alpha") (:form . "interferon-alpha")\n  (:end . 129) (:start . 113) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 137) (:start . 133)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s130.1) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001182@unknown@formal@none@1@S@Binding of type I interferon (IFN-alpha/beta) to specific receptors results in the rapid transcriptional activation, independent of protein synthesis, of IFN-alpha-stimulated genes (ISGs) in human fibroblasts and HeLa and Daudi cell lines.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-alpha/beta") (:form . "IFN-alpha/beta")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 104) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 128)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ifn-alpha-stimulated")\n  (:form . "IFN-alpha-stimulated") (:end . 174) (:start . 154) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 182) (:start . 181)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "ISG") (:form . "ISGs") (:end . 186) (:start . 182)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 196)\n  (:start . 191) (:id . 72))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 208)\n  (:start . 197) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 217) (:start . 213)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 227)\n  (:start . 222) (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 232) (:start . 228)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 238)\n  (:start . 233) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s130.2) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001183@unknown@formal@none@1@S@The binding of ISGF3 (IFN-stimulated gene factor 3) to the conserved IFN-stimulated response element (ISRE) results in transcriptional activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ISGF3") (:form . "ISGF3") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ifn-stimulated") (:form . "IFN-stimulated")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "JJ") (:stem . "ifn-stimulated") (:form . "IFN-stimulated")\n  (:end . 83) (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "ISRE") (:form . "ISRE") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 134) (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s130.3) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001184@unknown@formal@none@1@S@This factor is composed of a DNA-binding protein (ISGF3 gamma), which normally is present in the cytoplasm, and other IFN-alpha-activated proteins which preexist as latent cytoplasmic precursors (ISGF3 alpha).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 106)\n  (:start . 97) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . "JJ") (:stem . "ifn-alpha-activated")\n  (:form . "IFN-alpha-activated") (:end . 137) (:start . 118) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "VBP") (:stem . "preexist") (:form . "preexist") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 171)\n  (:start . 165) (:id . 70))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 183)\n  (:start . 172) (:id . 71))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 201)\n  (:start . 196) (:id . 74))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 207)\n  (:start . 202) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s130.4) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001185@unknown@formal@none@1@S@We have found that ISG expression in the monocytic U937 cell line differs from most cell lines previously examined.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ISG") (:form . "ISG") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s130.5) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001186@unknown@formal@none@1@S@U937 cells express both type I and type II IFN receptors, but only IFN-alpha is capable of inducing antiviral protection in these cells.@(((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 76)\n  (:start . 67) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 87)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s130.6) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001187@unknown@formal@none@1@S@Pretreatment with IFN-gamma potentiates the IFN-alpha-induced protection, but IFN-gamma alone does not have any antiviral activity.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ifn-alpha-induced") (:form . "IFN-alpha-induced")\n  (:end . 61) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 72)\n  (:start . 62) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 93) (:start . 88)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 98) (:start . 94)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x130.7.1) (:span 99 102)))\n (:nscopes ((:id . :x130.7.1) (:span 99 130)))\n (:identifiers (:sid . :s130.7) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001188@unknown@formal@none@1@S@ISG15 mRNA accumulation in U937 cells is not detectable before 6 h of IFN-alpha treatment, peaks at 24 h, and requires protein synthesis.@(((:tag . "NNP") (:stem . "ISG15") (:form . "ISG15") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "peak") (:form . "peaks") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 118)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 126)\n  (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x130.8.1) (:span 41 44)))\n (:nscopes ((:id . :x130.8.1) (:span 41 89)))\n (:identifiers (:sid . :s130.8) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001190@unknown@formal@none@1@S@Nuclear extracts assayed for the presence of ISRE binding factors by electrophoretic mobility shift assays show that ISGF3 is induced by IFN-alpha within 6 h from undetectable basal levels in untreated U937 cells.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ISRE") (:form . "ISRE") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 84) (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 153)\n  (:start . 147) (:id . 64))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 162) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 175)\n  (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 181)\n  (:start . 176) (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 188)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 201)\n  (:start . 192) (:id . 72))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s130.10) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001191@unknown@formal@none@1@S@Activation of ISGF3 alpha, the latent component of ISGF3, occurs rapidly.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ISGF3") (:form . "ISGF3") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s130.11) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001192@unknown@formal@none@1@S@However, the increase in ISGF3 activity ultimately correlates with the accumulation of ISGF3 gamma induced by IFN-alpha or IFN-gamma.(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-gamma.(ABSTRACT")\n  (:form . "IFN-gamma.(ABSTRACT") (:end . 142) (:start . 123) (:id . 61))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 152)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 165)\n  (:start . 160) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x130.12.1) (:span 120 122)))\n (:hscopes ((:id . :x130.12.1) (:span 110 132)))\n (:identifiers (:sid . :s130.12) (:did . :|92251244|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001193@unknown@formal@none@1@S@The mechanism of action of cyclosporin A and FK506.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s131.1) (:did . :|92255823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001194@unknown@formal@none@1@S@CsA and FK506 are powerful suppressors of the immune system, most notably of T cells.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "suppressor") (:form . "suppressors") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "notably") (:form . "notably") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s131.2) (:did . :|92255823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001195@unknown@formal@none@1@S@They act at a point in activation that lies between receptor ligation and the transcription of early genes.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s131.3) (:did . :|92255823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001196@unknown@formal@none@1@S@Here, Stuart Schreiber and Gerald Crabtree review recent findings that indicate  CsA and FK506 operate as prodrugs:@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Stuart") (:form . "Stuart") (:end . 12)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "Schreiber") (:form . "Schreiber") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Gerald") (:form . "Gerald") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "Crabtree") (:form . "Crabtree") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "review") (:form . "review") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "operate") (:form . "operate") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "prodrug") (:form . "prodrugs") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x131.4.1) (:span 71 79)))\n (:hscopes ((:id . :x131.4.1) (:span 71 114)))\n (:identifiers (:sid . :s131.4) (:did . :|92255823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001197@unknown@formal@none@1@S@they bind endogenous intracellular receptors, the immunophilins, and the resulting complex targets the protein phosphatase, calcineurin, to exert the immunosuppressive effect.@(((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "immunophilin") (:form . "immunophilins")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "VBZ") (:stem . "target") (:form . "targets") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 122)\n  (:start . 111) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 135)\n  (:start . 124) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 167) (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 174)\n  (:start . 168) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s131.5) (:did . :|92255823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001198@unknown@formal@none@1@S@[Plasma cortisol concentration and blood leukocyte content of glucocorticoid receptors in patients with deficiency-cold vs deficiency-heat syndromes]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "plasma") (:form . "Plasma") (:end . 7) (:start . 1)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 76) (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "deficiency-cold") (:form . "deficiency-cold")\n  (:end . 119) (:start . 104) (:id . 56))\n ((:tag . "CC") (:stem . "vs") (:form . "vs") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "deficiency-heat") (:form . "deficiency-heat")\n  (:end . 138) (:start . 123) (:id . 58))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 148)\n  (:start . 139) (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 149) (:start . 148)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s132.1) (:did . :|92257680|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001200@unknown@formal@none@1@S@As a result, the cases of deficiency-cold syndrome (DCS) had a normal concentration of plasma cortisol but a lowered content of GCR in leukocytes when compared with the normal control (P less than 0.05);@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "deficiency-cold") (:form . "deficiency-cold")\n  (:end . 41) (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DCS") (:form . "DCS") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 69)\n  (:start . 63) (:id . 56))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 83) (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 93)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lowered") (:form . "lowered") (:end . 116)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 124)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 145)\n  (:start . 135) (:id . 68))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 150) (:start . 146)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 159)\n  (:start . 151) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 175)\n  (:start . 169) (:id . 73))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 183)\n  (:start . 176) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 186) (:start . 185)\n  (:id . 76))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 191) (:start . 187)\n  (:id . 77))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 196) (:start . 192)\n  (:id . 78))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 201) (:start . 197)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 80))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 203) (:start . 202)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s132.3) (:did . :|92257680|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001201@unknown@formal@none@1@S@the cases of deficiency-heat syndrome (DHS) had a higher concentration of plasma cortisol than the normal control (P less than 0.05) and a slightly higher content of GCR in leukocytes.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "deficiency-heat") (:form . "deficiency-heat")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DHS") (:form . "DHS") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 56) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 147)\n  (:start . 139) (:id . 69))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 154)\n  (:start . 148) (:id . 70))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 162)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 169) (:start . 166)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 183)\n  (:start . 173) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s132.4) (:did . :|92257680|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001202@unknown@formal@none@1@S@It was concluded that the DCS is characterized by diminished biological effects of adrenocortical activity, while the DHS, by augmented biological effects of adrenocortical activity.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DCS") (:form . "DCS") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 46) (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adrenocortical") (:form . "adrenocortical")\n  (:end . 97) (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DHS") (:form . "DHS") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "augmented") (:form . "augmented") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "adrenocortical") (:form . "adrenocortical")\n  (:end . 172) (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 181)\n  (:start . 173) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s132.5) (:did . :|92257680|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001203@unknown@formal@none@1@S@Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 88) (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s133.1) (:did . :|92260664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001204@unknown@formal@none@1@S@NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tat-i") (:form . "tat-I") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 122) (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 148) (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s133.2) (:did . :|92260664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001205@unknown@formal@none@1@S@To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "ability") (:form . "abilities") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Tat-I") (:form . "Tat-I") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 184)\n  (:start . 175) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 198) (:start . 185) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 215)\n  (:start . 209) (:id . 77))\n ((:tag . "NNP") (:stem . "T-leukemia") (:form . "T-leukemia") (:end . 226)\n  (:start . 216) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 232)\n  (:start . 227) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x133.3.1) (:span 13 20)))\n (:hscopes ((:id . :x133.3.1) (:span 13 88)))\n (:identifiers (:sid . :s133.3) (:did . :|92260664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001206@unknown@formal@none@1@S@We have found that the p49 ( 100 ) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p49") (:form . "p49") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 52))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 64)\n  (:start . 56) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 82) (:start . 79)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 61))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 93)\n  (:start . 86) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Tat-I") (:form . "Tat-I") (:end . 104)\n  (:start . 99) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 65))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 117)\n  (:start . 108) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 132)\n  (:start . 122) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HIV-CAT") (:form . "HIV-CAT") (:end . 143)\n  (:start . 136) (:id . 70))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 151)\n  (:start . 144) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x133.4.1) (:span 75 78)))\n (:hscopes ((:id . :x133.4.1) (:span 75 151)))\n (:identifiers (:sid . :s133.4) (:did . :|92260664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001207@unknown@formal@none@1@S@Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells.@(((:tag . "JJ") (:stem . "little") (:form . "Little") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 86)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 110)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 140)\n  (:start . 131) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 148) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 157)\n  (:start . 149) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x133.5.1) (:span 127 130)))\n (:nscopes ((:id . :x133.5.1) (:span 127 172)))\n (:identifiers (:sid . :s133.5) (:did . :|92260664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001208@unknown@formal@none@1@S@These findings suggest that the combination of p49 ( 100 ) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p49") (:form . "p49") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tat-i") (:form . "tat-I") (:end . 111)\n  (:start . 106) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 124)\n  (:start . 117) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 137)\n  (:start . 128) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 151)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 162) (:start . 159)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x133.6.1) (:span 78 81)) ((:id . :x133.6.2) (:span 15 22)))\n (:hscopes ((:id . :x133.6.1) (:span 78 162))\n  ((:id . :x133.6.2) (:span 15 162)))\n (:identifiers (:sid . :s133.6) (:did . :|92260664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001210@unknown@formal@none@1@S@The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 68) (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x134.2.1) (:span 18 26)))\n (:hscopes ((:id . :x134.2.1) (:span 18 38)))\n (:identifiers (:sid . :s134.2) (:did . :|92260679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001211@unknown@formal@none@1@S@Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s134.3) (:did . :|92260679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001212@unknown@formal@none@1@S@The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cell") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 128) (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 167)\n  (:start . 157) (:id . 71))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 176)\n  (:start . 168) (:id . 72))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 187)\n  (:start . 177) (:id . 73))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 195)\n  (:start . 188) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x134.4.2) (:span 4 12)))\n (:ncues ((:id . :x134.4.1) (:span 145 148))\n  ((:id . :x134.4.3) (:span 30 33)))\n (:hscopes ((:id . :x134.4.2) (:span 4 26)))\n (:nscopes ((:id . :x134.4.1) (:span 145 195))\n  ((:id . :x134.4.3) (:span 0 143)))\n (:identifiers (:sid . :s134.4) (:did . :|92260679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001213@unknown@formal@none@1@S@Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "differentiation/retrodifferentiation")\n  (:form . "differentiation/retrodifferentiation") (:end . 96) (:start . 60)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 52))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 111)\n  (:start . 106) (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 120)\n  (:start . 112) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s135.1) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001214@unknown@formal@none@1@S@Human U-937 leukemia cells differentiate along the monocytic lineage following 3-day exposures to 12-O-tetradecanoylphorbol-13-acetate (TPA).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "U-937") (:form . "U-937") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "3-day") (:form . "3-day") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 134) (:start . 98)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 139) (:start . 136)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s135.2) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001215@unknown@formal@none@1@S@This induction of differentiation is accompanied by adherence and loss of proliferation, as well as expression/repression of differentiation-associated genes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 87) (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression/repression")\n  (:form . "expression/repression") (:end . 121) (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "differentiation-associated")\n  (:form . "differentiation-associated") (:end . 151) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 157)\n  (:start . 152) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s135.3) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001216@unknown@formal@none@1@S@Long term culture of TPA-differentiated U-937 cells in the absence of phorbol ester for 32-36 days resulted in a process of retrodifferentiation.@(((:tag . "JJ") (:stem . "long") (:form . "Long") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tpa-differentiated") (:form . "TPA-differentiated")\n  (:end . 39) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "32-36") (:form . "32-36") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "retrodifferentiation")\n  (:form . "retrodifferentiation") (:end . 144) (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s135.4) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001217@unknown@formal@none@1@S@The retrodifferentiated cells detached from the substrate and reinitiated proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "retrodifferentiate")\n  (:form . "retrodifferentiated") (:end . 23) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "detach") (:form . "detached") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reinitiate") (:form . "reinitiated") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s135.5) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001218@unknown@formal@none@1@S@Other cellular parameters, such as glycosidase activities, cytokine release, and filament expression, returned to levels similar to that observed in uninduced cells.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glycosidase") (:form . "glycosidase") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "filament") (:form . "filament") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s135.6) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001220@unknown@formal@none@1@S@Increased levels of membrane-associated PKC activity persisted until 17-29 days.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "membrane-associated")\n  (:form . "membrane-associated") (:end . 39) (:start . 20) (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "VBD") (:stem . "persist") (:form . "persisted") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "CD") (:stem . "17-29") (:form . "17-29") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s135.8) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001221@unknown@formal@none@1@S@However, longer periods of incubation were associated with a return to the distribution of PKC in control cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "period") (:form . "periods") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "return") (:form . "return") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 87)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s135.9) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001222@unknown@formal@none@1@S@Activation of PKC has been implicated in the regulation of certain immediate early response genes, and in the present studies, TPA rapidly induced c-fos and c-jun gene expression.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 167) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s135.10) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001223@unknown@formal@none@1@S@Levels of c-fos and c-jun transcripts remained elevated during periods of PKC activation and also returned to levels observed in control cells by 30-36 days, when the cells entered retrodifferentiation.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "period") (:form . "periods") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "CD") (:stem . "30-36") (:form . "30-36") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "VBD") (:stem . "enter") (:form . "entered") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "retrodifferentiation")\n  (:form . "retrodifferentiation") (:end . 201) (:start . 181) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s135.11) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001224@unknown@formal@none@1@S@Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "NNP") (:stem . "Staurosporine") (:form . "Staurosporine")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nonspecific") (:form . "nonspecific") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 126) (:start . 113) (:id . 58))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 136)\n  (:start . 127) (:id . 59))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 148)\n  (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 154)\n  (:start . 149) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 164)\n  (:start . 159) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "expression.(ABSTRACT")\n  (:form . "expression.(ABSTRACT") (:end . 190) (:start . 170) (:id . 65))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 200)\n  (:start . 191) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 203) (:start . 201)\n  (:id . 67))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 207) (:start . 204)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 213)\n  (:start . 208) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 214) (:start . 213)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s135.12) (:did . :|92265660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001225@unknown@formal@none@1@S@The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 41)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 65) (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s136.1) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001226@unknown@formal@none@1@S@The CD19 protein is expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells and has been implicated as a signal-transducing receptor in the control of proliferation and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "b-lymphoid") (:form . "B-lymphoid") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "RB") (:stem . "terminally") (:form . "terminally") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 116) (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "signal-transducing") (:form . "signal-transducing")\n  (:end . 177) (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 71))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 218) (:start . 205) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 238) (:start . 223) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x136.2.1) (:span 69 90)))\n (:nscopes ((:id . :x136.2.1) (:span 69 129)))\n (:identifiers (:sid . :s136.2) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001227@unknown@formal@none@1@S@Here we demonstrate complete correlation between the expression pattern of the CD19 gene and the B-cell-specific transcription factor BSAP in a large panel of B-lymphoid cell lines.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 112) (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 126) (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 133)\n  (:start . 127) (:id . 59))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "b-lymphoid") (:form . "B-lymphoid") (:end . 169)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s136.3) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001228@unknown@formal@none@1@S@The human CD19 gene has been cloned, and several BSAP-binding sites have been mapped by in vitro protein-DNA binding studies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "JJ") (:stem . "bsap-binding") (:form . "BSAP-binding") (:end . 61)\n  (:start . 49) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 84) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s136.4) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001230@unknown@formal@none@1@S@Moreover, this site is occupied by BSAP in vivo in a CD19-expressing B-cell line but not in plasma or HeLa cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cd19-expressing") (:form . "CD19-expressing")\n  (:end . 68) (:start . 53) (:id . 54))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 98)\n  (:start . 92) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x136.6.1) (:span 85 88)))\n (:nscopes ((:id . :x136.6.1) (:span 85 112)))\n (:identifiers (:sid . :s136.6) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001231@unknown@formal@none@1@S@This high-affinity site has been conserved in the promoters of both human and mouse CD19 genes and was furthermore shown to confer B-cell specificity to a beta-globin reporter gene in transient transfection experiments.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "RB") (:stem . "furthermore") (:form . "furthermore") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 149)\n  (:start . 138) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 166)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 193)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 206)\n  (:start . 194) (:id . 73))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 218)\n  (:start . 207) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s136.7) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001232@unknown@formal@none@1@S@In addition, BSAP was found to be the only abundant DNA-binding activity of B-cell nuclear extracts that interacts with the CD19 promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 63)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s136.8) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001233@unknown@formal@none@1@S@Together, this evidence strongly implicates BSAP in the regulation of the CD19 gene.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "implicate") (:form . "implicates") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x136.9.1) (:span 33 43)))\n (:hscopes ((:id . :x136.9.1) (:span 33 83)))\n (:identifiers (:sid . :s136.9) (:did . :|92269839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001234@unknown@formal@none@1@S@Reduced susceptibility to HIV-1 infection of ethyl-methanesulfonate-treated CEM subclones correlates with a blockade in their protein kinase C signaling pathway.@(((:tag . "VBN") (:stem . "reduce") (:form . "Reduced") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 22) (:start . 8) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ethyl-methanesulfonate-treated")\n  (:form . "ethyl-methanesulfonate-treated") (:end . 75) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 79) (:start . 76)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 89)\n  (:start . 80) (:id . 50))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 100)\n  (:start . 90) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 53))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 116)\n  (:start . 108) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 125)\n  (:start . 120) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 133)\n  (:start . 126) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 140)\n  (:start . 134) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 152)\n  (:start . 143) (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 160)\n  (:start . 153) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s137.1) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001235@unknown@formal@none@1@S@We have described the isolation of chemically induced CEM subclones that express CD4 receptors and bind soluble gp120, yet show a markedly reduced susceptibility to infection with HIV-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "chemically") (:form . "chemically") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "gp120") (:form . "gp120") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 161) (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s137.2) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001236@unknown@formal@none@1@S@Two subclones were found to have an abnormal response to the protein kinase C (PKC) activator PMA.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 93)\n  (:start . 84) (:id . 59))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s137.3) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001237@unknown@formal@none@1@S@PMA treatment induced CD3 and CD25 (IL-2R) receptors on the parental line and on other ethyl-methanesulfonate-derived subclones, but not on these two mutants.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD25") (:form . "CD25") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ethyl-methanesulfonate-derived")\n  (:form . "ethyl-methanesulfonate-derived") (:end . 117) (:start . 87)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x137.4.1) (:span 133 136)))\n (:nscopes ((:id . :x137.4.1) (:span 133 157)))\n (:identifiers (:sid . :s137.4) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001238@unknown@formal@none@1@S@Direct assays of PKC activity were conducted.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s137.5) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001240@unknown@formal@none@1@S@PMA-induced CD4 down-modulation occurred normally.@(((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CD4") (:form . "CD4") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "down-modulation") (:form . "down-modulation")\n  (:end . 31) (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s137.7) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001241@unknown@formal@none@1@S@In addition, activation of c-raf kinase was normal.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-raf") (:form . "c-raf") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s137.8) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001242@unknown@formal@none@1@S@Since HIV-1 long terminal repeat contains two functional nuclear factor kB (NF-kB) regulatory elements, we studied the ability of PMA to induce NF-kB binding activity by different assays.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "kB") (:form . "kB") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 157)\n  (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 179)\n  (:start . 170) (:id . 71))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 186)\n  (:start . 180) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s137.9) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001243@unknown@formal@none@1@S@Chloramphenicol acetyl transferase (CAT) assays using the HIV-1 ( -139 ) long terminal repeat-CAT construct showed no PMA induction of CAT activity in these subclones (unlike the parental line and other subclones).@(((:tag . "NNP") (:stem . "Chloramphenicol") (:form . "Chloramphenicol")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 22)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 34)\n  (:start . 23) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-139") (:form . "-139") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "repeat-cat") (:form . "repeat-CAT") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 174)\n  (:start . 168) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 187)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 202)\n  (:start . 197) (:id . 75))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 212)\n  (:start . 203) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x137.10.1) (:span 115 117)))\n (:nscopes ((:id . :x137.10.1) (:span 115 166)))\n (:identifiers (:sid . :s137.10) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001244@unknown@formal@none@1@S@Okadaic acid, an inhibitor of phosphatases 1 and 2A, did not overcome the defect in these subclones.@(((:tag . "JJ") (:stem . "okadaic") (:form . "Okadaic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "VB") (:stem . "overcome") (:form . "overcome") (:end . 69)\n  (:start . 61) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 80)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 99)\n  (:start . 90) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x137.11.1) (:span 57 60)))\n (:nscopes ((:id . :x137.11.1) (:span 57 99)))\n (:identifiers (:sid . :s137.11) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001245@unknown@formal@none@1@S@Gel retardation assays, using a 32P-probe containing the HIV-1 NF-kB probe and nuclear extracts from PMA-treated cells, showed significantly reduced induction of nuclear NF-kB binding proteins in these two subclones compared with wild type CEM and a control subclone.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "32p-probe") (:form . "32P-probe") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pma-treated") (:form . "PMA-treated") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 175)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 192)\n  (:start . 184) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 201)\n  (:start . 196) (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 205) (:start . 202)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 215)\n  (:start . 206) (:id . 73))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 224)\n  (:start . 216) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 229) (:start . 225)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 234) (:start . 230)\n  (:id . 76))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 239) (:start . 235)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 243) (:start . 240)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 249) (:start . 248)\n  (:id . 80))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 257)\n  (:start . 250) (:id . 81))\n ((:tag . "NN") (:stem . "subclone") (:form . "subclone") (:end . 266)\n  (:start . 258) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s137.12) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001246@unknown@formal@none@1@S@Deoxycholate treatment of cytoplasmic extracts from these subclones released much reduced NF-kB binding proteins from their cytoplasmic pools.@(((:tag . "NNP") (:stem . "Deoxycholate") (:form . "Deoxycholate") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 95) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 112)\n  (:start . 104) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 135)\n  (:start . 124) (:id . 58))\n ((:tag . "NNS") (:stem . "pool") (:form . "pools") (:end . 141)\n  (:start . 136) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s137.13) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001247@unknown@formal@none@1@S@Thus, reduced levels of PKC-induced nuclear NF-kB activity in two T cell subclones did not affect their normal cell growth, but correlated with a pronounced reduction in their susceptibility to HIV-1 infection.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pkc-induced") (:form . "PKC-induced") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "nf-kb") (:form . "NF-kB") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 103)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 138)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 156)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 190) (:start . 176) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 199)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x137.14.1) (:span 87 90)))\n (:nscopes ((:id . :x137.14.1) (:span 87 122)))\n (:identifiers (:sid . :s137.14) (:did . :|92291523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001248@unknown@formal@none@1@S@Eicosanoids in breast cancer patients before and after mastectomy.@(((:tag . "NNS") (:stem . "eicosanoid") (:form . "Eicosanoids") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mastectomy") (:form . "mastectomy") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s138.1) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001250@unknown@formal@none@1@S@Values were compared with those of patients with benign tumors (n = 4), or undergoing a mammary reduction (n = 7).@(((:tag . "NNS") (:stem . "value") (:form . "Values") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "benign") (:form . "benign") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 85)\n  (:start . 75) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 95)\n  (:start . 88) (:id . 61))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 105)\n  (:start . 96) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 108) (:start . 107)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 110) (:start . 109)\n  (:id . 65))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 112) (:start . 111)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s138.3) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001251@unknown@formal@none@1@S@Postoperatively, blood was taken as well in order to compare pre- and postoperative values.@(((:tag . "RB") (:stem . "postoperatively") (:form . "Postoperatively")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "pre-") (:form . "pre-") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "postoperative") (:form . "postoperative")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s138.4) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001252@unknown@formal@none@1@S@Eicosanoids were measured in peripheral blood monocytes and mammary tissue by means of HPLC;@(((:tag . "NNS") (:stem . "eicosanoid") (:form . "Eicosanoids") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HPLC") (:form . "HPLC") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s138.5) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001253@unknown@formal@none@1@S@furthermore, TXA2, 6-keto-PGF1 alpha, and PGE2 were determined by RIA.@(((:tag . "RB") (:stem . "furthermore") (:form . "furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TXA2") (:form . "TXA2") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "6-keto-pgf1") (:form . "6-keto-PGF1") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RIA") (:form . "RIA") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s138.6) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001254@unknown@formal@none@1@S@Differences in pre- and postoperative values of cancer patients were seen in plasma RIA values:@(((:tag . "NNS") (:stem . "difference") (:form . "Differences") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pre-") (:form . "pre-") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "postoperative") (:form . "postoperative")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "RIA") (:form . "RIA") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s138.7) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001255@unknown@formal@none@1@S@PGE2 and 6-k-PGF1 alpha were significantly higher preoperatively when compared with postoperatively, however , such differences were seen in the control groups as well.@(((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "6-k-pgf1") (:form . "6-k-PGF1") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 49) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "preoperatively") (:form . "preoperatively")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "RB") (:stem . "postoperatively") (:form . "postoperatively")\n  (:end . 99) (:start . 84) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 127)\n  (:start . 116) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 132) (:start . 128)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 159)\n  (:start . 153) (:id . 64))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 167) (:start . 163)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s138.8) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001256@unknown@formal@none@1@S@Compared to benign tumor or mammary reduction test material the eicosanoid profile of tissue obtained from malignant mammary tumors showed important differences.@(((:tag . "VBN") (:stem . "compare") (:form . "Compared") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "benign") (:form . "benign") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "material") (:form . "material") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "eicosanoid") (:form . "eicosanoid") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 160)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s138.9) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001257@unknown@formal@none@1@S@Except for PGF2 alpha, HHT and 15-HETE no detectable quantities of eicosanoids were found in the non-tumor material, whereas in the malignant tumor material substantial quantities of a number of eicosanoid metabolites were present.@(((:tag . "IN") (:stem . "except") (:form . "Except") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pgf2") (:form . "PGF2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HHT") (:form . "HHT") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "15-hete") (:form . "15-HETE") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "quantity") (:form . "quantities") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "eicosanoid") (:form . "eicosanoids") (:end . 78)\n  (:start . 67) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-tumor") (:form . "non-tumor") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "material") (:form . "material") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 141)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "material") (:form . "material") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 168)\n  (:start . 157) (:id . 68))\n ((:tag . "NNS") (:stem . "quantity") (:form . "quantities") (:end . 179)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 191)\n  (:start . 185) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "NN") (:stem . "eicosanoid") (:form . "eicosanoid") (:end . 205)\n  (:start . 195) (:id . 74))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 217)\n  (:start . 206) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 230)\n  (:start . 223) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x138.10.1) (:span 39 41)))\n (:nscopes ((:id . :x138.10.1) (:span 39 115)))\n (:identifiers (:sid . :s138.10) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001258@unknown@formal@none@1@S@Statistically significant correlations could be established between patient/histopathology data and the results of the platelet aggregation assays, e.g.@(((:tag . "RB") (:stem . "statistically") (:form . "Statistically")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "correlation") (:form . "correlations") (:end . 38)\n  (:start . 26) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 44) (:start . 39)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 59)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 67)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "patient/histopathology")\n  (:form . "patient/histopathology") (:end . 90) (:start . 68) (:id . 49))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 95) (:start . 91)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 111)\n  (:start . 104) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 55))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 127)\n  (:start . 119) (:id . 56))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 139)\n  (:start . 128) (:id . 57))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 146)\n  (:start . 140) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 59))\n ((:tag . "NN") (:stem . "e.g") (:form . "e.g") (:end . 151) (:start . 148)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x138.11.1) (:span 39 44)))\n (:hscopes ((:id . :x138.11.1) (:span 0 146)))\n (:identifiers (:sid . :s138.11) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001260@unknown@formal@none@1@S@The results show that eicosanoid synthesis in material from mammary cancer patients is different from that in benign mammary tissue.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "eicosanoid") (:form . "eicosanoid") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "material") (:form . "material") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "benign") (:form . "benign") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s138.13) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001261@unknown@formal@none@1@S@The implications, in particular, in relation to future prognosis of the patient, remain obscure.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "prognosis") (:form . "prognosis") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "obscure") (:form . "obscure") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s138.14) (:did . :|92294188|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001262@unknown@formal@none@1@S@c-myc mRNA expression in minor salivary glands of patients with Sjogren 's syndrome.@(((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Sjogren") (:form . "Sjogren") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s139.1) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001263@unknown@formal@none@1@S@c-myc protooncogene is implicated in the pathogenesis of B cell lymphoid malignancies and high levels of c-myc mRNA expression are observed in activated blood mononuclear cells.@(((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 53)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 170)\n  (:start . 159) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s139.2) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001264@unknown@formal@none@1@S@Sjogren 's syndrome (SS) is characterized by lymphocytic infiltrates of exocrine glands, remarkable B cell hyperreactivity and a strong predisposition to B cell neoplasia.@(((:tag . "NNP") (:stem . "Sjogren") (:form . "Sjogren") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 41) (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "infiltrate") (:form . "infiltrates") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "exocrine") (:form . "exocrine") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "remarkable") (:form . "remarkable") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hyperreactivity") (:form . "hyperreactivity")\n  (:end . 122) (:start . 107) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "predisposition") (:form . "predisposition")\n  (:end . 150) (:start . 136) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "neoplasia") (:form . "neoplasia") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s139.3) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001265@unknown@formal@none@1@S@In this study, c-myc protooncogene mRNA expression in 29 labial minor salivary gland biopsies from patients with primary SS and 15 controls was examined using in situ hybridization histochemistry.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "labial") (:form . "labial") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "biopsy") (:form . "biopsies") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 158) (:start . 153)\n  (:id . 67))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 180) (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "histochemistry") (:form . "histochemistry")\n  (:end . 195) (:start . 181) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s139.4) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001266@unknown@formal@none@1@S@Two 40mer oligonucleotides from the 1st and the 2nd exon of the c-myc gene, labeled with 35S, were used as probes.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "40mer") (:form . "40mer") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 26) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "1st") (:form . "1st") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "2nd") (:form . "2nd") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "label") (:form . "labeled") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "35s") (:form . "35S") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 113)\n  (:start . 107) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s139.5) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001267@unknown@formal@none@1@S@To detect the origin of the cell hybridized with a c-myc probe, a combined immunochemistry in situ hybridization histochemistry technique was used.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "hybridize") (:form . "hybridized") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "NN") (:stem . "immunochemistry") (:form . "immunochemistry")\n  (:end . 90) (:start . 75) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 112) (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "histochemistry") (:form . "histochemistry")\n  (:end . 127) (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s139.6) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001268@unknown@formal@none@1@S@High c-myc mRNA expression was detected on acinar epithelial cells.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "acinar") (:form . "acinar") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s139.7) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001270@unknown@formal@none@1@S@Stronger c-myc mRNA expression was detected in labial salivary glands of patients with longer disease duration (p less than or equal to 0.002) and more intense T lymphocyte infiltrates (p less than 0.05) although these patients revealed no hypergammaglobulinemia.@(((:tag . "JJR") (:stem . "strong") (:form . "Stronger") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "labial") (:form . "labial") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 93) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "duration") (:form . "duration") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "CD") (:stem . "0.002") (:form . "0.002") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "intense") (:form . "intense") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 172)\n  (:start . 162) (:id . 71))\n ((:tag . "NNS") (:stem . "infiltrate") (:form . "infiltrates") (:end . 184)\n  (:start . 173) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 197) (:start . 193)\n  (:id . 76))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 202) (:start . 198)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 78))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 212)\n  (:start . 204) (:id . 79))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 218)\n  (:start . 213) (:id . 80))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 227)\n  (:start . 219) (:id . 81))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 236)\n  (:start . 228) (:id . 82))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 239) (:start . 237)\n  (:id . 83))\n ((:tag . "NN") (:stem . "hypergammaglobulinemia")\n  (:form . "hypergammaglobulinemia") (:end . 262) (:start . 240) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x139.9.1) (:span 237 239)))\n (:nscopes ((:id . :x139.9.1) (:span 237 262)))\n (:identifiers (:sid . :s139.9) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001271@unknown@formal@none@1@S@No correlation was observed between c-myc mRNA and B lymphocyte monoclonicity or lymphoma.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "monoclonicity") (:form . "monoclonicity")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x139.10.1) (:span 0 2)))\n (:nscopes ((:id . :x139.10.1) (:span 0 89)))\n (:identifiers (:sid . :s139.10) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001272@unknown@formal@none@1@S@In conclusion, strong c-myc mRNA expression was observed on epithelial cells of labial salivary glands from patients with primary SS.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "labial") (:form . "labial") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s139.11) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001273@unknown@formal@none@1@S@Our findings may indicate the presence of a reactivated virus hosted in these cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reactivate") (:form . "reactivated") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "host") (:form . "hosted") (:end . 68) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x139.12.1) (:span 17 25))\n  ((:id . :x139.12.2) (:span 13 16)))\n (:hscopes ((:id . :x139.12.1) (:span 17 83))\n  ((:id . :x139.12.2) (:span 13 83)))\n (:identifiers (:sid . :s139.12) (:did . :|92309248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001274@unknown@formal@none@1@S@Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes.@(((:tag . "JJ") (:stem . "cytoplasmic") (:form . "Cytoplasmic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "heterogeneity") (:form . "heterogeneity")\n  (:end . 32) (:start . 19) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s140.1) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001275@unknown@formal@none@1@S@B lymphocytes and macrophages express closely related immunoglobulin G (IgG) Fc receptors (Fc gamma RII) that differ only in the structures of their cytoplasmic domains.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 68) (:start . 54) (:id . 49))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RII") (:form . "RII") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 139)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 160)\n  (:start . 149) (:id . 69))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 168)\n  (:start . 161) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s140.2) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001276@unknown@formal@none@1@S@Because of cell type-specific alternative messenger RNA splicing, B-cell Fc gamma RII contains an insertion of 47 amino acids that participates in determining receptor function in these cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cell") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RII") (:form . "RII") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 143)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 176)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 185)\n  (:start . 180) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s140.3) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001277@unknown@formal@none@1@S@Transfection of an Fc gamma RII-negative B-cell line with complementary DNA 's encoding the two splice products and various receptor mutants indicated that the insertion was responsible for preventing both Fc gamma RII-mediated endocytosis and Fc gamma RII-mediated antigen presentation.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "rii-negative") (:form . "RII-negative") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 185)\n  (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 200)\n  (:start . 190) (:id . 70))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 205) (:start . 201)\n  (:id . 71))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "JJ") (:stem . "rii-mediated") (:form . "RII-mediated") (:end . 227)\n  (:start . 215) (:id . 74))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 239)\n  (:start . 228) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 76))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 246) (:start . 244)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 252)\n  (:start . 247) (:id . 78))\n ((:tag . "JJ") (:stem . "rii-mediated") (:form . "RII-mediated") (:end . 265)\n  (:start . 253) (:id . 79))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 273)\n  (:start . 266) (:id . 80))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 286)\n  (:start . 274) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 287) (:start . 286)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x140.4.1) (:span 141 155)))\n (:hscopes ((:id . :x140.4.1) (:span 141 286)))\n (:identifiers (:sid . :s140.4) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001278@unknown@formal@none@1@S@The insertion was not required for Fc gamma RII to modulate surface immunoglobulin-triggered B-cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RII") (:form . "RII") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "immunoglobulin-triggered")\n  (:form . "immunoglobulin-triggered") (:end . 92) (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x140.5.1) (:span 18 21)))\n (:nscopes ((:id . :x140.5.1) (:span 18 110)))\n (:identifiers (:sid . :s140.5) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001280@unknown@formal@none@1@S@In contrast, the insertion did contribute to the formation of caps in response to receptor cross-linking, consistent with suggestions that the lymphocyte but not macrophage form of the receptor can associate with the detergent-insoluble cytoskeleton.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cap") (:form . "caps") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "suggestion") (:form . "suggestions") (:end . 133)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 193)\n  (:start . 185) (:id . 72))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 207)\n  (:start . 198) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 212) (:start . 208)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "detergent-insoluble")\n  (:form . "detergent-insoluble") (:end . 236) (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "cytoskeleton") (:form . "cytoskeleton") (:end . 249)\n  (:start . 237) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x140.7.1) (:span 194 197))\n  ((:id . :x140.7.3) (:span 122 133)))\n (:ncues ((:id . :x140.7.2) (:span 158 161)))\n (:hscopes ((:id . :x140.7.1) (:span 194 249))\n  ((:id . :x140.7.3) (:span 122 249)))\n (:nscopes ((:id . :x140.7.2) (:span 158 172)))\n (:identifiers (:sid . :s140.7) (:did . :|92311659|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001281@unknown@formal@none@1@S@Every enhancer works with every promoter for all the combinations tested:@(((:tag . "DT") (:stem . "every") (:form . "Every") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "work") (:form . "works") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 72) (:start . 66)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s141.1) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001282@unknown@formal@none@1@S@could new regulatory pathways evolve by enhancer shuffling?@(((:tag . "MD") (:stem . "could") (:form . "could") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "evolve") (:form . "evolve") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "shuffling") (:form . "shuffling") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 59) (:start . 58)\n  (:id . 50)))@@@1@9@((:hcues ((:id . :x141.2.1) (:span 0 5)))\n (:hscopes ((:id . :x141.2.1) (:span 0 58)))\n (:identifiers (:sid . :s141.2) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001283@unknown@formal@none@1@S@The promoters and enhancers of cell type-specific genes are often conserved in evolution, and hence one might expect that a given enhancer has evolved to work best with its own promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "one") (:form . "one") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "VB") (:stem . "expect") (:form . "expect") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "VB") (:stem . "work") (:form . "work") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "RB") (:stem . "best") (:form . "best") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 185)\n  (:start . 177) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x141.3.1) (:span 110 116))\n  ((:id . :x141.3.2) (:span 104 109)))\n (:hscopes ((:id . :x141.3.1) (:span 110 185))\n  ((:id . :x141.3.2) (:span 104 185)))\n (:identifiers (:sid . :s141.3) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001284@unknown@formal@none@1@S@While this expectation may be realized in some cases, we have not found evidence for it.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expectation") (:form . "expectation") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "realize") (:form . "realized") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x141.4.2) (:span 23 26)))\n (:ncues ((:id . :x141.4.1) (:span 62 65)))\n (:hscopes ((:id . :x141.4.2) (:span 6 52)))\n (:nscopes ((:id . :x141.4.1) (:span 62 87)))\n (:identifiers (:sid . :s141.4) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001285@unknown@formal@none@1@S@A total of 27 combinations of different promoters and enhancers were tested by transfection into cultured cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 26)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 75) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s141.5) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001286@unknown@formal@none@1@S@We found that the relative efficiency of the enhancers is approximately the same, irrespective of the type of promoter used, i.e. , there was no strong preference for any given enhancer/promoter combination.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "irrespective") (:form . "irrespective") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 151)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "preference") (:form . "preference") (:end . 162)\n  (:start . 152) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 170) (:start . 167)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 176)\n  (:start . 171) (:id . 73))\n ((:tag . "NN") (:stem . "enhancer/promoter") (:form . "enhancer/promoter")\n  (:end . 194) (:start . 177) (:id . 74))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 206)\n  (:start . 195) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x141.6.1) (:span 142 144)))\n (:nscopes ((:id . :x141.6.1) (:span 142 206)))\n (:identifiers (:sid . :s141.6) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001287@unknown@formal@none@1@S@Notably, we do not see particularly strong transcription when the immunoglobulin kappa enhancer ( or the immunoglobulin heavy chain enhancer) is used to activate a kappa gene promoter.@(((:tag . "RB") (:stem . "notably") (:form . "Notably") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 80) (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 119) (:start . 105) (:id . 59))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 183)\n  (:start . 175) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x141.7.1) (:span 15 18)))\n (:nscopes ((:id . :x141.7.1) (:span 15 183)))\n (:identifiers (:sid . :s141.7) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001288@unknown@formal@none@1@S@We propose that a generally permissive enhancer/promoter interaction is of evolutionary benefit for higher eukaryotes: by enhancer shuffling, genes could be easily brought under a new type of inducibility/cell type specificity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "enhancer/promoter") (:form . "enhancer/promoter")\n  (:end . 56) (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 68)\n  (:start . 57) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 87)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "benefit") (:form . "benefit") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 118) (:start . 117)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "shuffling") (:form . "shuffling") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "RB") (:stem . "easily") (:form . "easily") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "VBN") (:stem . "bring") (:form . "brought") (:end . 171)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 177)\n  (:start . 172) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "inducibility/cell") (:form . "inducibility/cell")\n  (:end . 209) (:start . 192) (:id . 72))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 214) (:start . 210)\n  (:id . 73))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 226)\n  (:start . 215) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x141.8.1) (:span 148 153)) ((:id . :x141.8.2) (:span 3 10)))\n (:hscopes ((:id . :x141.8.1) (:span 148 226))\n  ((:id . :x141.8.2) (:span 3 117)))\n (:identifiers (:sid . :s141.8) (:did . :|92314696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001290@unknown@formal@none@1@S@The NF-kappa B family of transcription proteins represents multiple DNA binding, rel related polypeptides that contribute to regulation of genes involved in immune responsiveness and inflammation, as well as activation of the HIV long terminal repeat.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 178) (:start . 164) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 195)\n  (:start . 183) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 204) (:start . 200)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 207) (:start . 205)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 218)\n  (:start . 208) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 229) (:start . 226)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 234) (:start . 230)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 243)\n  (:start . 235) (:id . 78))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 250)\n  (:start . 244) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s142.2) (:did . :|92317168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001291@unknown@formal@none@1@S@In this study multiple NF-kappa B related polypeptides ranging from 85 to 45 kDa were examined for their capacity to interact with the PRDII regulatory element of interferon beta and were shown to possess distinct intrinsic DNA binding affinities for this NF-kappa B site and form multiple DNA binding homo- and heterodimer complexes in co-renaturation experiments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "related") (:form . 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5001292@unknown@formal@none@1@S@Furthermore, using DNA templates containing two copies of the PRDII domain linked to the rabbit beta globin gene, the purified polypeptides specifically stimulated NF-kappa B dependent transcription in an in vitro reconstitution assay as heterodimers but not as p50 homodimers.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "template") (:form . "templates") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 54) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PRDII") (:form . "PRDII") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 81) (:start . 75)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 139)\n  (:start . 127) (:id . 64))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 152)\n  (:start . 140) (:id . 65))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 172)\n  (:start . 164) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 184)\n  (:start . 175) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 213)\n  (:start . 208) (:id . 74))\n ((:tag . "NN") (:stem . "reconstitution") (:form . "reconstitution")\n  (:end . 228) (:start . 214) (:id . 75))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 234)\n  (:start . 229) (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 237) (:start . 235)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 250)\n  (:start . 238) (:id . 78))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 254) (:start . 251)\n  (:id . 79))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 258) (:start . 255)\n  (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 261) (:start . 259)\n  (:id . 81))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 265) (:start . 262)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 276)\n  (:start . 266) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x142.4.1) (:span 255 258)))\n (:nscopes ((:id . :x142.4.1) (:span 255 276)))\n (:identifiers (:sid . :s142.4) (:did . :|92317168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001293@unknown@formal@none@1@S@These experiments emphasize the role of NF-kappa B dimerization as a distinct level of transcriptional control that may permit functional diversification of a limited number of regulatory proteins.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "emphasize") (:form . "emphasize") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 102) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "VB") (:stem . "permit") (:form . "permit") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 137)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "diversification") (:form . "diversification")\n  (:end . 153) (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 166)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 173)\n  (:start . 167) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 187)\n  (:start . 177) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 196)\n  (:start . 188) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x142.5.1) (:span 116 119)))\n (:hscopes ((:id . :x142.5.1) (:span 116 196)))\n (:identifiers (:sid . :s142.5) (:did . :|92317168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001294@unknown@formal@none@1@S@Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity.@(((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "remote") (:form . "remote") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "b-cell-restricted") (:form . "B-cell-restricted")\n  (:end . 81) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s143.1) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001295@unknown@formal@none@1@S@Previous cotransfection experiments had demonstrated that ectopic expression of the lymphocyte-specific transcription factor Oct2 could efficiently activate a promoter containing an octamer motif.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 23) (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 35)\n  (:start . 24) (:id . 44))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 39) (:start . 36)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 52)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 103) (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 117) (:start . 104) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 124)\n  (:start . 118) (:id . 54))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 129) (:start . 125)\n  (:id . 55))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 135)\n  (:start . 130) (:id . 56))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 147)\n  (:start . 136) (:id . 57))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 156)\n  (:start . 148) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 167)\n  (:start . 159) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 178)\n  (:start . 168) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 181) (:start . 179)\n  (:id . 62))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 189)\n  (:start . 182) (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 195)\n  (:start . 190) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x143.2.1) (:span 130 135)))\n (:hscopes ((:id . :x143.2.1) (:span 130 195)))\n (:identifiers (:sid . :s143.2) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001296@unknown@formal@none@1@S@Oct2 expression was unable to stimulate a multimerized octamer enhancer element in HeLa cells, however.@(((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x143.3.1) (:span 20 26)))\n (:nscopes ((:id . :x143.3.1) (:span 20 93)))\n (:identifiers (:sid . :s143.3) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001297@unknown@formal@none@1@S@We have tested a variety of Oct2 isoforms generated by alternative splicing for the capability to activate an octamer enhancer in nonlymphoid cells and a B-cell line.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "capability") (:form . "capability") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 141)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 160)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s143.4) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001298@unknown@formal@none@1@S@Our analyses show that several Oct2 isoforms can stimulate from a remote position but that this stimulation is restricted to B cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "remote") (:form . "remote") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s143.5) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001300@unknown@formal@none@1@S@Mutational analyses indicate that the carboxy-terminal domain of Oct2 is critical for enhancer activation.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 54) (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 61)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x143.7.1) (:span 20 33)))\n (:hscopes ((:id . :x143.7.1) (:span 20 105)))\n (:identifiers (:sid . :s143.7) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001301@unknown@formal@none@1@S@Moreover, this domain conferred enhancing activity when fused to the Oct1 protein, which by itself was unable to stimulate from a remote position.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "enhancing") (:form . "enhancing") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "oct1") (:form . "Oct1") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "remote") (:form . "remote") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x143.8.1) (:span 103 109)))\n (:nscopes ((:id . :x143.8.1) (:span 103 145)))\n (:identifiers (:sid . :s143.8) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001302@unknown@formal@none@1@S@The glutamine-rich activation domain present in the amino-terminal portion of Oct2 and the POU domain contribute only marginally to the transactivation function from a distal position.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "glutamine-rich") (:form . "glutamine-rich")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 66) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "RB") (:stem . "marginally") (:form . "marginally") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 151) (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 160)\n  (:start . 152) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 174)\n  (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s143.9) (:did . :|92318928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001303@unknown@formal@none@1@S@Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s144.1) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001304@unknown@formal@none@1@S@Oct-2 is a transcription factor that binds specifically to octamer DNA motifs in the promoters of immunoglobulin and interleukin-2 genes.@(((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 24) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 112) (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s144.2) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001305@unknown@formal@none@1@S@All tumor cell lines from the B-cell lineage and a few from the T-cell lineage express Oct-2.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 70)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s144.3) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001306@unknown@formal@none@1@S@To address the role of Oct-2 in the T-cell lineage, we studied the expression of Oct-2 mRNA and protein in nontransformed human and mouse T cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nontransformed") (:form . "nontransformed")\n  (:end . 121) (:start . 107) (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s144.4) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001307@unknown@formal@none@1@S@Oct-2 was found in CD4+ and CD8+ T cells prepared from human peripheral blood and in mouse lymph node T cells.@(((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s144.5) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001308@unknown@formal@none@1@S@In a T-cell clone specific for pigeon cytochrome c in the context of I-Ek, Oct-2 was induced by antigen stimulation, with the increase in Oct-2 protein seen first at 3 h after activation and continuing for at least 24 h.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pigeon") (:form . "pigeon") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "I-Ek") (:form . "I-Ek") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 92)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 115)\n  (:start . 104) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 134)\n  (:start . 126) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 143)\n  (:start . 138) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 151)\n  (:start . 144) (:id . 69))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 162)\n  (:start . 157) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 167) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 169) (:start . 168)\n  (:id . 74))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 175)\n  (:start . 170) (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 186)\n  (:start . 176) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "continue") (:form . "continuing") (:end . 201)\n  (:start . 191) (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 205) (:start . 202)\n  (:id . 79))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 208) (:start . 206)\n  (:id . 80))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 214)\n  (:start . 209) (:id . 81))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 217) (:start . 215)\n  (:id . 82))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 219) (:start . 218)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s144.6) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001310@unknown@formal@none@1@S@These results suggest that Oct-2 participates in transcriptional regulation during T-cell activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 64) (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 82)\n  (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x144.8.1) (:span 14 21)))\n (:hscopes ((:id . :x144.8.1) (:span 14 100)))\n (:identifiers (:sid . :s144.8) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001311@unknown@formal@none@1@S@The relatively delayed kinetics of Oct-2 induction suggests that Oct-2 mediates the changes in gene expression which occur many hours or days following antigen stimulation of T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 171)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 188)\n  (:start . 177) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x144.9.1) (:span 51 59)))\n (:hscopes ((:id . :x144.9.1) (:span 51 188)))\n (:identifiers (:sid . :s144.9) (:did . :|92318932|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001312@unknown@formal@none@1@S@[Changes in plasma interleukin-1 and their possible relationship with the changes in glucocorticoid receptor in aged long-distance runner]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 8)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 42)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 99) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "long-distance") (:form . "long-distance")\n  (:end . 130) (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "runner") (:form . "runner") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x145.1.1) (:span 43 51)))\n (:hscopes ((:id . :x145.1.1) (:span 43 137)))\n (:identifiers (:sid . :s145.1) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001313@unknown@formal@none@1@S@For the study of the changes in plasma interleukin-1 (IL-1) and their possible relationship with the changes in glucocorticoid receptor (GR), plasma IL-1 and GR in peripheral blood leukocytes in aged long-distance runner were measured simultaneously.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 52) (:start . 39) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 69)\n  (:start . 64) (:id . 55))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 126) (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 148)\n  (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 174)\n  (:start . 164) (:id . 73))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 180)\n  (:start . 175) (:id . 74))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 191)\n  (:start . 181) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "long-distance") (:form . "long-distance")\n  (:end . 213) (:start . 200) (:id . 78))\n ((:tag . "NN") (:stem . "runner") (:form . "runner") (:end . 220)\n  (:start . 214) (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 234)\n  (:start . 226) (:id . 81))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 249) (:start . 235) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x145.2.1) (:span 70 78)))\n (:hscopes ((:id . :x145.2.1) (:span 70 220)))\n (:identifiers (:sid . :s145.2) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001314@unknown@formal@none@1@S@The activity of IL-1 was expressed as its ability to stimulate 3H-TdR incorporation in the thymocytes of C57 mice.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "3h-tdr") (:form . "3H-TdR") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c57") (:form . "C57") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 113)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s145.3) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001315@unknown@formal@none@1@S@GR was determined by whole cell assay with 3H-Dex.@(((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "3H-Dex") (:form . "3H-Dex") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s145.4) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001316@unknown@formal@none@1@S@The results showed that the activity of plasma IL-1 in aged long-distance runner was 209 %, 223 % and 145 % of the control at 14.7-18.7, 3.8-7.0 and 1.5-2.6 KD fractions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long-distance") (:form . "long-distance")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "runner") (:form . "runner") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "CD") (:stem . "209") (:form . "209") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "CD") (:stem . "223") (:form . "223") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "CD") (:stem . "145") (:form . "145") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 122)\n  (:start . 115) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 125) (:start . 123)\n  (:id . 67))\n ((:tag . "CD") (:stem . "14.7-18.7") (:form . "14.7-18.7") (:end . 135)\n  (:start . 126) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 69))\n ((:tag . "CD") (:stem . "3.8-7.0") (:form . "3.8-7.0") (:end . 144)\n  (:start . 137) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 71))\n ((:tag . "CD") (:stem . "1.5-2.6") (:form . "1.5-2.6") (:end . 156)\n  (:start . 149) (:id . 72))\n ((:tag . "NN") (:stem . "kd") (:form . "KD") (:end . 159) (:start . 157)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 169)\n  (:start . 160) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s145.5) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001317@unknown@formal@none@1@S@The GR in peripheral blood leukocytes in aged runner was 65 % of the control.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "runner") (:form . "runner") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s145.6) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001318@unknown@formal@none@1@S@Possible relationship between the changes in IL-1 and GR in aged long-distance runner and its physiological significance are discussed.@(((:tag . "JJ") (:stem . "possible") (:form . "Possible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long-distance") (:form . "long-distance")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "runner") (:form . "runner") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 120)\n  (:start . 108) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x145.7.1) (:span 0 8)))\n (:hscopes ((:id . :x145.7.1) (:span 0 85)))\n (:identifiers (:sid . :s145.7) (:did . :|92320321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001320@unknown@formal@none@1@S@The HTLV-I LTR contains three conserved regulatory elements known as 21 base pair repeats which are required for stimulation of gene expression by the transactivator protein tax.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 124)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 165) (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 173)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s146.2) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001321@unknown@formal@none@1@S@Mutagenesis indicates that the 21 bp repeats can be subdivided into three motifs, A, B and C, each of which influences the level of tax activation.@(((:tag . "NNP") (:stem . "Mutagenesis") (:form . "Mutagenesis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "subdivide") (:form . "subdivided") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 61))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 98) (:start . 94)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 64))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 118)\n  (:start . 108) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 128)\n  (:start . 123) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 135) (:start . 132)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x146.3.1) (:span 45 48)) ((:id . :x146.3.2) (:span 12 26)))\n (:hscopes ((:id . :x146.3.1) (:span 27 92))\n  ((:id . :x146.3.2) (:span 12 146)))\n (:identifiers (:sid . :s146.3) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001322@unknown@formal@none@1@S@The A site in the 21 bp repeat has strong homology with previously described binding sites for the transcription factor AP-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 23) (:start . 21)\n  (:id . 48))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 30)\n  (:start . 24) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 41)\n  (:start . 35) (:id . 51))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 66)\n  (:start . 56) (:id . 54))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s146.4) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001323@unknown@formal@none@1@S@We demonstrated that AP-2 mRNA was present in T-lymphocytes and that cellular factors from both non-transformed and transformed T-lymphocytes specifically bound to the consensus motif for AP-2 in each 21 bp.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AP-2") (:form . "AP-2") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "non-transformed") (:form . "non-transformed")\n  (:end . 111) (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 141) (:start . 128) (:id . 60))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 154)\n  (:start . 142) (:id . 61))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 160)\n  (:start . 155) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 177)\n  (:start . 168) (:id . 65))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 183)\n  (:start . 178) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 187) (:start . 184)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 192) (:start . 188)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 69))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 203) (:start . 201)\n  (:id . 71))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 206) (:start . 204)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s146.5) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001324@unknown@formal@none@1@S@To determine the role of AP-2 in the regulation of the HTLV-I LTR gene expression, we used an AP-2 cDNA in DNA binding and transient expression assays.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 132)\n  (:start . 123) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 68))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s146.6) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001325@unknown@formal@none@1@S@Gel retardation and methylation interference studies revealed that bacterially produced AP-2 bound specifically and with high affinity to all three 21 bp repeats, and that it required the core sequence AGGC for specific binding.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "RB") (:stem . "bacterially") (:form . "bacterially") (:end . 78)\n  (:start . 67) (:id . 50))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 92) (:start . 88)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 98) (:start . 93)\n  (:id . 53))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 111)\n  (:start . 99) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 125) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 134)\n  (:start . 126) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 141) (:start . 138)\n  (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 183)\n  (:start . 175) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 201)\n  (:start . 193) (:id . 72))\n ((:tag . "NNP") (:stem . "AGGC") (:form . "AGGC") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 219)\n  (:start . 211) (:id . 75))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 227)\n  (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s146.7) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001326@unknown@formal@none@1@S@Binding of AP-2 prevented the subsequent binding of members of the CREB/ATF family to an adjacent regulatory motif in the 21 bp repeat.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s146.8) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001327@unknown@formal@none@1@S@Transfection of an AP-2 expression construct into T-lymphocytes activated gene expression from the HTLV-I LTR.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s146.9) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001328@unknown@formal@none@1@S@At least two 21 bp repeats were required for high levels of AP-2 activation and mutagenesis of the AP-2 consensus binding sequences in the 21 bp repeats eliminate this activation.(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 91)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 113)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "VBP") (:stem . "eliminate") (:form . "eliminate") (:end . 162)\n  (:start . 153) (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 167) (:start . 163)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "activation.(ABSTRACT")\n  (:form . "activation.(ABSTRACT") (:end . 188) (:start . 168) (:id . 71))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 198)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 211)\n  (:start . 206) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s146.10) (:did . :|92331609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001330@unknown@formal@none@1@S@The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation/repression")\n  (:form . "activation/repression") (:end . 36) (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 61)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 84) (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 100) (:start . 85) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 104) (:start . 101)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 53))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 112) (:start . 109)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 117) (:start . 113)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 126)\n  (:start . 118) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x147.2.1) (:span 105 108)))\n (:nscopes ((:id . :x147.2.1) (:span 0 126)))\n (:identifiers (:sid . :s147.2) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001331@unknown@formal@none@1@S@The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid-expressed")\n  (:form . "erythroid-expressed") (:end . 109) (:start . 90) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 115)\n  (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "mature") (:form . "maturing") (:end . 127)\n  (:start . 119) (:id . 57))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 141) (:start . 128) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s147.3) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001332@unknown@formal@none@1@S@We analyzed GATA-1 expression in early human adult hematopoiesis by using an in vitro system in which " pure " early hematopoietic progenitors are induced to gradual and synchronized differentiation selectively along the erythroid or granulocyte-macrophage pathway by differential treatment with hematopoietic growth factors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 58))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pure") (:form . "pure") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 130) (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 142)\n  (:start . 131) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "gradual") (:form . "gradual") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "synchronize") (:form . "synchronized") (:end . 182)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 198) (:start . 183) (:id . 71))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 210)\n  (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 216)\n  (:start . 211) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 230)\n  (:start . 221) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 233) (:start . 231)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 256) (:start . 234) (:id . 77))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 264)\n  (:start . 257) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 267) (:start . 265)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 280)\n  (:start . 268) (:id . 80))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 290)\n  (:start . 281) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 295) (:start . 291)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 309) (:start . 296) (:id . 83))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 316)\n  (:start . 310) (:id . 84))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 324)\n  (:start . 317) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 325) (:start . 324)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s147.4) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001333@unknown@formal@none@1@S@The GATA-1 gene, though virtually silent in quiescent progenitors, is activated after entrance into the cell cycle upon stimulation with hematopoietic growth factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "silent") (:form . "silent") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "entrance") (:form . "entrance") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 150) (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 157)\n  (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 165)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s147.5) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001334@unknown@formal@none@1@S@Subsequently, increasing expression along the erythroid pathway contrasts with an abrupt downregulation in the granulocyte-macrophage lineage.@(((:tag . "RB") (:stem . "subsequently") (:form . "Subsequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "VBZ") (:stem . "contrast") (:form . "contrasts") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "abrupt") (:form . "abrupt") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 103) (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 133) (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 141)\n  (:start . 134) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s147.6) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001335@unknown@formal@none@1@S@These results suggest a microenvironment-directed, two-step model for GATA-1 expression in differentiating hematopoietic progenitors that involves ( i ) cycle-dependent initiation and ( ii ) lineage-dependent maintenance or suppression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "microenvironment-directed")\n  (:form . "microenvironment-directed") (:end . 49) (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "two-step") (:form . "two-step") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 106) (:start . 91) (:id . 54))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 120) (:start . 107) (:id . 55))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 132)\n  (:start . 121) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 146)\n  (:start . 138) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 59))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 150) (:start . 149)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cycle-dependent") (:form . "cycle-dependent")\n  (:end . 168) (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 179)\n  (:start . 169) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 185) (:start . 184)\n  (:id . 65))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 188) (:start . 186)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "lineage-dependent") (:form . "lineage-dependent")\n  (:end . 208) (:start . 191) (:id . 68))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 220)\n  (:start . 209) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 223) (:start . 221)\n  (:id . 70))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 235)\n  (:start . 224) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x147.7.1) (:span 14 21)))\n (:hscopes ((:id . :x147.7.1) (:span 14 235)))\n (:identifiers (:sid . :s147.7) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001336@unknown@formal@none@1@S@Hypothetically, on/off switches of lineage-restricted transactivators may underlie the binary fate decisions of hematopoietic progenitors.@(((:tag . "RB") (:stem . "hypothetically") (:form . "Hypothetically")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "on/off") (:form . "on/off") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "switch") (:form . "switches") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lineage-restricted") (:form . "lineage-restricted")\n  (:end . 53) (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 69) (:start . 54) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 73) (:start . 70)\n  (:id . 49))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 82)\n  (:start . 74) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 93)\n  (:start . 87) (:id . 52))\n ((:tag . "NN") (:stem . "fate") (:form . "fate") (:end . 98) (:start . 94)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "decision") (:form . "decisions") (:end . 108)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 125) (:start . 112) (:id . 56))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 137)\n  (:start . 126) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x147.8.1) (:span 70 73)) ((:id . :x147.8.2) (:span 0 14)))\n (:hscopes ((:id . :x147.8.1) (:span 70 137))\n  ((:id . :x147.8.2) (:span 0 137)))\n (:identifiers (:sid . :s147.8) (:did . :|92335296|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001337@unknown@formal@none@1@S@[Age-related changes in glucocorticoid and mineralocorticoid receptors in lymphocytes of healthy persons and patients with hypertension]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "age-related") (:form . "Age-related") (:end . 12)\n  (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 60) (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 85)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "NNS") (:stem . "person") (:form . "persons") (:end . 104)\n  (:start . 97) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 135)\n  (:start . 123) (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 136) (:start . 135)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s148.1) (:did . :|92362919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001338@unknown@formal@none@1@S@It has been found that the number of glucocorticoid receptors in lymphocytes of the peripheral blood of healthy elderly subjects increases , while the number of mineralocorticoid receptors decreases.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 51) (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 178) (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 198)\n  (:start . 189) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s148.2) (:did . :|92362919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001340@unknown@formal@none@1@S@the number of glucocorticoid and mineralocorticoid binding sites grows in hypertensive patients.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 50) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "grow") (:form . "grows") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hypertensive") (:form . "hypertensive") (:end . 86)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s148.4) (:did . :|92362919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001341@unknown@formal@none@1@S@Still a more essential rise in the number of receptors is observed in mid-age hypertensive patients than in elderly ones.@(((:tag . "RB") (:stem . "still") (:form . "Still") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mid-age") (:form . "mid-age") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "JJ") (:stem . "hypertensive") (:form . "hypertensive") (:end . 90)\n  (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s148.5) (:did . :|92362919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001342@unknown@formal@none@1@S@In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 120) (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 151)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s149.1) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001343@unknown@formal@none@1@S@Analysis of the major histocompatibility complex class II gene promoter DRA has previously identified at least five cis-acting regions required for maximal expression.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 40) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 155)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 166)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s149.2) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001344@unknown@formal@none@1@S@We have examined the DRA promoter for protein-DNA interactions in the intact cell, which may mediate transcriptional activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 116) (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x149.3.1) (:span 89 92)))\n (:hscopes ((:id . :x149.3.1) (:span 89 127)))\n (:identifiers (:sid . :s149.3) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001345@unknown@formal@none@1@S@Using in vivo genomic footprinting we identified interactions in B-cell lines at the octamer site and the Y, X1, and X2 boxes.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Y") (:form . "Y") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "X1") (:form . "X1") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 125) (:start . 120)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s149.4) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001346@unknown@formal@none@1@S@Class II antigen expressing T-cell lines maintained contacts identical to B-cell lines, while class II-negative T-cell lines exhibited no interactions.@(((:tag . "NNP") (:stem . "Class") (:form . "Class") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "maintain") (:form . "maintained") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "contact") (:form . "contacts") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ii-negative") (:form . "II-negative") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 150)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x149.5.1) (:span 135 137)))\n (:nscopes ((:id . :x149.5.1) (:span 135 150)))\n (:identifiers (:sid . :s149.5) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001347@unknown@formal@none@1@S@In lymphoid cell lines, the octamer site is occupied and required for maximal expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s149.6) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001348@unknown@formal@none@1@S@This is most likely due to the presence of the lymphoid-specific OTF-2 factor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 64) (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x149.7.1) (:span 13 19)))\n (:hscopes ((:id . :x149.7.1) (:span 13 77)))\n (:identifiers (:sid . :s149.7) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001350@unknown@formal@none@1@S@Thus, the DRA promoter discriminates against OTF-1 activation at the level of DNA binding in the glioblastoma line.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 22)\n  (:start . 14) (:id . 46))\n ((:tag . "VBZ") (:stem . "discriminate") (:form . "discriminates")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "glioblastoma") (:form . "glioblastoma") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s149.9) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001351@unknown@formal@none@1@S@Interferon gamma induces class II expression in this glioblastoma cell line and , in parallel, up-regulates X1 and X2 box protein-DNA interactions, while all other interactions remain unchanged.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferon") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "glioblastoma") (:form . "glioblastoma") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "up-regulates") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "x1") (:form . "X1") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 133)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 146)\n  (:start . 134) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 176)\n  (:start . 164) (:id . 69))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 193)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s149.10) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001352@unknown@formal@none@1@S@These results suggest that interferon gamma functions on a poised promoter by altering weak , nonproductive interactions at the X boxes to strong interactions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "poise") (:form . "poised") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nonproductive") (:form . "nonproductive")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 120)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 135) (:start . 130)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 158)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x149.11.1) (:span 14 21)))\n (:hscopes ((:id . :x149.11.1) (:span 14 158)))\n (:identifiers (:sid . :s149.11) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001353@unknown@formal@none@1@S@These findings provide direct in vivo evidence to strongly suggest that the modulation of X1 and X2 interactions is an important constituent of the interferon gamma induction pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "x1") (:form . "X1") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 112)\n  (:start . 100) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "constituent") (:form . "constituent") (:end . 140)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 182)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x149.12.1) (:span 59 66)))\n (:hscopes ((:id . :x149.12.1) (:span 59 182)))\n (:identifiers (:sid . :s149.12) (:did . :|92366509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001354@unknown@formal@none@1@S@Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.@(((:tag . "JJ") (:stem . "simple") (:form . "Simple") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "derivation") (:form . "derivation") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "tfiid-dependent") (:form . "TFIID-dependent")\n  (:end . 36) (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "FW") (:stem . "schizosaccharomyces")\n  (:form . "Schizosaccharomyces") (:end . 101) (:start . 82) (:id . 52))\n ((:tag . "FW") (:stem . "pombe") (:form . "pombe") (:end . 107)\n  (:start . 102) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 117)\n  (:start . 112) (:id . 55))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 127)\n  (:start . 118) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 140)\n  (:start . 133) (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 149)\n  (:start . 141) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 153) (:start . 150)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 169) (:start . 154) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 180)\n  (:start . 170) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s150.1) (:did . :|92366521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001355@unknown@formal@none@1@S@Resolution of whole cell extract through two chromatographic steps yields a single protein fraction requiring only the addition of TFIID for the initiation of transcription at RNA polymerase II promoters.@(((:tag . "NNP") (:stem . "Resolution") (:form . "Resolution") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "chromatographic") (:form . "chromatographic")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "yield") (:form . "yields") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 172) (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 190)\n  (:start . 180) (:id . 69))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 193) (:start . 191)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 203)\n  (:start . 194) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s150.2) (:did . :|92366521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001356@unknown@formal@none@1@S@This approach allows the convenient generation of RNA polymerase II transcription systems from Saccharomyces cerevisiae, human lymphocytes, and Schizosaccharomyces pombe.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "convenient") (:form . "convenient") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Saccharomyces") (:form . "Saccharomyces")\n  (:end . 108) (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 119)\n  (:start . 109) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "FW") (:stem . "schizosaccharomyces")\n  (:form . "Schizosaccharomyces") (:end . 163) (:start . 144) (:id . 62))\n ((:tag . "FW") (:stem . "pombe") (:form . "pombe") (:end . 169)\n  (:start . 164) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s150.3) (:did . :|92366521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001357@unknown@formal@none@1@S@TFIIDs from all three organisms are interchangeable among all three systems.@(((:tag . "NNS") (:stem . "tfiid") (:form . "TFIIDs") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "interchangeable") (:form . "interchangeable")\n  (:end . 51) (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s150.4) (:did . :|92366521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001358@unknown@formal@none@1@S@The S. cerevisiae and Sch. pombe systems support effects of acidic activator proteins, provided a further protein fraction from S. cerevisiae is supplied.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "FW") (:stem . "sch.") (:form . "Sch.") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "FW") (:stem . "pombe") (:form . "pombe") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "supply") (:form . "supplied") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s150.5) (:did . :|92366521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001360@unknown@formal@none@1@S@NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "VBZ") (:stem . "underlie") (:form . "underlies") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "self-perpetuation") (:form . "self-perpetuation")\n  (:end . 102) (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 128) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 134)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 148) (:start . 135) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 161)\n  (:start . 152) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s151.1) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001361@unknown@formal@none@1@S@The molecular mechanisms underlying the sustained nuclear translocation of NF-kappa B observed in U937 monocytic cells chronically infected with human immunodeficiency virus (HIV) were studied.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 71) (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 130)\n  (:start . 119) (:id . 58))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 139)\n  (:start . 131) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 150)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 167) (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 173)\n  (:start . 168) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 178) (:start . 175)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 192)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s151.2) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001362@unknown@formal@none@1@S@The activity of the promoter regulating the synthesis of the p105 precursor of the NF-kappa B p50 subunit was enhanced in these cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s151.3) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001363@unknown@formal@none@1@S@Deletions in this promoter indicated that this upregulation was mediated through the NF-kappa B- but not the AP-1-binding motif, by bona fide p50/p65 heterodimers.@(((:tag . "NNS") (:stem . "deletion") (:form . "Deletions") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "NNP") (:stem . "B-") (:form . "B-") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bona") (:form . "bona") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "fide") (:form . "fide") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 162)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x151.4.2) (:span 27 41)))\n (:ncues ((:id . :x151.4.1) (:span 101 104)))\n (:hscopes ((:id . :x151.4.2) (:span 27 162)))\n (:nscopes ((:id . :x151.4.1) (:span 101 127)))\n (:identifiers (:sid . :s151.4) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001364@unknown@formal@none@1@S@Analysis of cytosolic extracts indicated that NF-kappa B levels were increased in HIV-infected cells.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 94)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x151.5.1) (:span 31 45)))\n (:hscopes ((:id . :x151.5.1) (:span 31 100)))\n (:identifiers (:sid . :s151.5) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001365@unknown@formal@none@1@S@In contrast to the transient NF-kappa B activation induced by phorbol ester, the permanent NF-kappa B translocation induced by HIV infection was not dependent on PKC isoenzymes alpha and beta as shown by the use of a specific inhibitor (GF 109203X).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "isoenzyme") (:form . "isoenzymes") (:end . 176)\n  (:start . 166) (:id . 69))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 191) (:start . 187)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 200)\n  (:start . 195) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 76))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 211) (:start . 208)\n  (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 216) (:start . 215)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 225)\n  (:start . 217) (:id . 80))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 235)\n  (:start . 226) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "GF") (:form . "GF") (:end . 239) (:start . 237)\n  (:id . 83))\n ((:tag . "NN") (:stem . "109203x") (:form . "109203X") (:end . 247)\n  (:start . 240) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x151.6.1) (:span 145 148)))\n (:nscopes ((:id . :x151.6.1) (:span 145 191)))\n (:identifiers (:sid . :s151.6) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001366@unknown@formal@none@1@S@These observations indicate that during chronic HIV infection of U937 cells, continuous NF-kappa B (p50/p65) translocation results in p105 promoter upregulation with subsequent cytosolic NF-kappa B accumulation, ready for further translocation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 122) (:start . 109) (:id . 60))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 160)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 176)\n  (:start . 166) (:id . 67))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 186)\n  (:start . 177) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 195)\n  (:start . 187) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 197) (:start . 196)\n  (:id . 70))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 210)\n  (:start . 198) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "ready") (:form . "ready") (:end . 217)\n  (:start . 212) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 221) (:start . 218)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 229)\n  (:start . 222) (:id . 75))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 243) (:start . 230) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x151.7.1) (:span 19 32)))\n (:hscopes ((:id . :x151.7.1) (:span 19 243)))\n (:identifiers (:sid . :s151.7) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001367@unknown@formal@none@1@S@This HIV-mediated mechanism results in a self-perpetuating loop of NF-kappa B production.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hiv-mediated") (:form . "HIV-mediated") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "self-perpetuating") (:form . "self-perpetuating")\n  (:end . 58) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s151.8) (:did . :|92366555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001368@unknown@formal@none@1@S@The development of functionally responsive T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s152.1) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001370@unknown@formal@none@1@S@First is an expansion phase prior to TCR rearrangement, which appears to be correlated with programming of at least some response genes for inducibility.@(((:tag . "JJ") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "programming") (:form . "programming") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 152)\n  (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x152.3.1) (:span 62 69)))\n (:hscopes ((:id . :x152.3.1) (:span 56 152)))\n (:identifiers (:sid . :s152.3) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001371@unknown@formal@none@1@S@This phase can occur to some extent outside of the thymus.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "outside") (:form . "outside") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x152.4.1) (:span 11 14)))\n (:hscopes ((:id . :x152.4.1) (:span 11 57)))\n (:identifiers (:sid . :s152.4) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001372@unknown@formal@none@1@S@However, the profound T cell deficit of nude mice indicates that the thymus is by far the most potent site for inducing the expansion per se, even if other sites can induce some response acquisition.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "deficit") (:form . "deficit") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nude") (:form . "nude") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 133)\n  (:start . 124) (:id . 66))\n ((:tag . "FW") (:stem . "per") (:form . "per") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "FW") (:stem . "se") (:form . "se") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 69))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 146) (:start . 142)\n  (:id . 70))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 149) (:start . 147)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 155)\n  (:start . 150) (:id . 72))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 161)\n  (:start . 156) (:id . 73))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 165) (:start . 162)\n  (:id . 74))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 172)\n  (:start . 166) (:id . 75))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 177) (:start . 173)\n  (:id . 76))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 186)\n  (:start . 178) (:id . 77))\n ((:tag . "NN") (:stem . "acquisition") (:form . "acquisition") (:end . 198)\n  (:start . 187) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x152.5.1) (:span 50 64)))\n (:hscopes ((:id . :x152.5.1) (:span 50 140)))\n (:identifiers (:sid . :s152.5) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001373@unknown@formal@none@1@S@Second is a controlled phase of TCR gene rearrangement.@(((:tag . "JJ") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "controlled") (:form . "controlled") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s152.6) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001374@unknown@formal@none@1@S@The details of the regulatory mechanism that selects particular loci for rearrangement are still not known.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "select") (:form . "selects") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "locus") (:form . "loci") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 86) (:start . 73) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x152.7.1) (:span 97 100)))\n (:nscopes ((:id . :x152.7.1) (:span 97 106)))\n (:identifiers (:sid . :s152.7) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001375@unknown@formal@none@1@S@It seems that the rearrangement of the TCR gamma loci in the gamma delta lineage may not always take place at a developmental stage strictly equivalent to the rearrangement of TCR beta in the alpha beta lineage, and it is not clear just how early the two lineages diverge.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TCR") (:form . 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5001376@unknown@formal@none@1@S@In the TCR alpha beta lineage, however, the final gene rearrangement events are accompanied by rapid proliferation and an interruption in cellular response gene inducibility.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 49) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 68) (:start . 55) (:id . 54))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 91)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interruption") (:form . "interruption") (:end . 134)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 173)\n  (:start . 161) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s152.9) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001377@unknown@formal@none@1@S@The loss of conventional responsiveness is probably caused by alterations at the level of signaling, and may be a manifestation of the physiological state that is a precondition for selection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "conventional") (:form . "conventional") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 39) (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "manifestation") (:form . "manifestation")\n  (:end . 127) (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 148) (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "precondition") (:form . "precondition") (:end . 177)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 71))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x152.10.1) (:span 105 108))\n  ((:id . :x152.10.2) (:span 43 51)))\n (:hscopes ((:id . :x152.10.1) (:span 105 191))\n  ((:id . :x152.10.2) (:span 43 99)))\n (:identifiers (:sid . :s152.10) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001378@unknown@formal@none@1@S@Third is the complex process of selection.@(((:tag . "JJ") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s152.11) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001380@unknown@formal@none@1@S@Negative selection in the cortex appears to be a suicidal inversion of antigen responsiveness:instead of turning on IL-2 expression, the activated cell destroys its own chromatin.@(((:tag . "JJ") (:stem . "negative") (:form . "Negative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "suicidal") (:form . "suicidal") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "inversion") (:form . "inversion") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "responsiveness:instead")\n  (:form . "responsiveness:instead") (:end . 101) (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "turn") (:form . "turning") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "destroy") (:form . "destroys") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 178)\n  (:start . 169) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x152.13.2) (:span 33 40)))\n (:ncues ((:id . :x152.13.1) (:span 94 104)))\n (:hscopes ((:id . :x152.13.2) (:span 0 93)))\n (:nscopes ((:id . :x152.13.1) (:span 94 131)))\n (:identifiers (:sid . :s152.13) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001381@unknown@formal@none@1@S@The genes that need to be induced for this response are not yet identified, but it is unquestionably a form of activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "need") (:form . "need") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 59))\n ((:tag . "RB") (:stem . "unquestionably") (:form . "unquestionably")\n  (:end . 100) (:start . 86) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x152.14.1) (:span 56 59)))\n (:nscopes ((:id . :x152.14.1) (:span 0 74)))\n (:identifiers (:sid . :s152.14) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001382@unknown@formal@none@1@S@It is interesting that in humans and rats, cortical thymocytes undergoing negative selection can still induce IL-2R alpha expression and even be rescued in vitro, if exogenous IL-2 is provided.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cortical") (:form . "cortical") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 68))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 175)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 192)\n  (:start . 184) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s152.15) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001383@unknown@formal@none@1@S@Perhaps murine thymocytes are denied this form of rescue because they shut off IL-2R beta chain expression at an earlier stage or because they may be uncommonly Bcl-2 deficient (cf.@(((:tag . "RB") (:stem . "perhaps") (:form . "Perhaps") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "deny") (:form . "denied") (:end . 36) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "shut") (:form . "shut") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "RP") (:stem . "off") (:form . "off") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "RB") (:stem . "uncommonly") (:form . "uncommonly") (:end . 160)\n  (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cf") (:form . "cf") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x152.16.1) (:span 143 146))\n  ((:id . :x152.16.2) (:span 127 129)) ((:id . :x152.16.3) (:span 0 7)))\n (:hscopes ((:id . :x152.16.1) (:span 143 176))\n  ((:id . :x152.16.2) (:span 57 176)) ((:id . :x152.16.3) (:span 0 56)))\n (:identifiers (:sid . :s152.16) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001384@unknown@formal@none@1@S@Sentman et al. , 1991; Strasser et al. , 1991).@(((:tag . "NNP") (:stem . "Sentman") (:form . "Sentman") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Strasser") (:form . "Strasser") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 45) (:start . 41)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s152.17) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001385@unknown@formal@none@1@S@Even so, medullary thymocytes remain at least partially susceptible to negative selection even as they continue to mature.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "medullary") (:form . "medullary") (:end . 18)\n  (:start . 9) (:id . 45))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "continue") (:form . "continue") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VB") (:stem . "mature") (:form . "mature") (:end . 121)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s152.18) (:did . :|92367617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001386@unknown@formal@none@1@S@SRC-related proto-oncogenes and transcription factors in primary human T cells: modulation by cyclosporin A and FK506.@(((:tag . "JJ") (:stem . "src-related") (:form . "SRC-related") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 53)\n  (:start . 46) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 64)\n  (:start . 57) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s153.1) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001387@unknown@formal@none@1@S@Activation of T lymphocytes induces transcription of genes encoding for lymphokines.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphokine") (:form . "lymphokines") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s153.2) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001388@unknown@formal@none@1@S@Interleukin-2 (IL-2) gene expression is controlled transcriptionally by the cooperative activity of specific trans-activating factors that bind to the IL-2 enhancer.@(((:tag . "NN") (:stem . "interleukin-2") (:form . "Interleukin-2")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 68) (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 125) (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 133)\n  (:start . 126) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 164)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s153.3) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001390@unknown@formal@none@1@S@A member of the src gene family, the lymphocyte-specific protein tyrosine kinase, p56lck, has been implicated in IL-2 production.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "src") (:form . "src") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 56) (:start . 37) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s153.5) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001391@unknown@formal@none@1@S@CsA was found not to inhibit lck gene expression, nor the activity of the lck gene product.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "lck") (:form . "lck") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lck") (:form . "lck") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x153.6.1) (:span 50 53)) ((:id . :x153.6.2) (:span 14 17)))\n (:nscopes ((:id . :x153.6.1) (:span 50 90))\n  ((:id . :x153.6.2) (:span 14 48)))\n (:identifiers (:sid . :s153.6) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001392@unknown@formal@none@1@S@However, CsA and FK506 inhibit the appearance of DNA binding activity of factors that bind to the NF-AT and AP-1 sites in the IL-2 enhancer.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 130) (:start . 126)\n  (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 139)\n  (:start . 131) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s153.7) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001393@unknown@formal@none@1@S@Since the induction of NF-AT and AP-1 is induced by the same stimuli that stimulate IL-2 production, these results indicate that the immunosuppressant action of CsA and FK506 is exerted at the level of these trans-activating factors.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 150) (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 174)\n  (:start . 169) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 185)\n  (:start . 178) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 74))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 198)\n  (:start . 193) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 76))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 207)\n  (:start . 202) (:id . 77))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 224) (:start . 208) (:id . 78))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 232)\n  (:start . 225) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x153.8.1) (:span 115 128)))\n (:hscopes ((:id . :x153.8.1) (:span 115 232)))\n (:identifiers (:sid . :s153.8) (:did . :|92368408|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001394@unknown@formal@none@1@S@TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.@(((:tag . "JJ") (:stem . "tar-independent") (:form . "TAR-independent")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 31) (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cns") (:form . "CNS") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s154.1) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001395@unknown@formal@none@1@S@The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive infection and is a potential target for antiviral therapy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 41) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s154.2) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001396@unknown@formal@none@1@S@Tat, a potent activator of HIV-1 gene expression, serves to greatly increase the rate of transcription directed by the viral promoter.@(((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 13) (:start . 7)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 23)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 59))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s154.3) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001397@unknown@formal@none@1@S@This induction, which seems to be an important component in the progression of acquired immune deficiency syndrome (AIDS), may be due to increased transcriptional initiation, increased transcriptional elongation, or a combination of these processes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 146)\n  (:start . 137) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 162) (:start . 147) (:id . 69))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 184)\n  (:start . 175) (:id . 72))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 200) (:start . 185) (:id . 73))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 211)\n  (:start . 201) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 217) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 229)\n  (:start . 218) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 79))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 238)\n  (:start . 233) (:id . 80))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 248)\n  (:start . 239) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x154.4.1) (:span 213 215))\n  ((:id . :x154.4.2) (:span 123 126)) ((:id . :x154.4.3) (:span 22 27)))\n (:hscopes ((:id . :x154.4.1) (:span 137 248))\n  ((:id . :x154.4.2) (:span 123 248)) ((:id . :x154.4.3) (:span 16 121)))\n (:identifiers (:sid . :s154.4) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001398@unknown@formal@none@1@S@Much attention has been focused on the interaction of Tat with a specific RNA target termed TAR (transactivation responsive) which is present in the leader sequence of all HIV-1 mRNAs.@(((:tag . "JJ") (:stem . "much") (:form . "Much") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "attention") (:form . "attention") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 91) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TAR") (:form . "TAR") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 112) (:start . 97) (:id . 60))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "leader") (:form . "leader") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 164)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 177)\n  (:start . 172) (:id . 72))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 183)\n  (:start . 178) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s154.5) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001400@unknown@formal@none@1@S@In this report we demonstrate that in certain CNS-derived cells Tat is capable of activating HIV-1 through a TAR-independent pathway.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "cns-derived") (:form . "CNS-derived") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "tar-independent") (:form . "TAR-independent")\n  (:end . 124) (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s154.7) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001401@unknown@formal@none@1@S@A Tat-responsive element is found upstream within the viral promoter that in glial-derived cell lines allows transactivation in the absence of TAR.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tat-responsive") (:form . "Tat-responsive")\n  (:end . 16) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "glial-derived") (:form . "glial-derived")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 124) (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TAR") (:form . "TAR") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s154.8) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001402@unknown@formal@none@1@S@Deletion mapping and hybrid promoter constructs demonstrate that the newly identified Tat-responsive element corresponds to a sequence within the viral long terminal repeat (LTR) previously identified as the HIV-1 enhancer, or NF-kappa B domain.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "JJ") (:stem . "tat-responsive") (:form . "Tat-responsive")\n  (:end . 100) (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 108)\n  (:start . 101) (:id . 54))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 120)\n  (:start . 109) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 134)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 141)\n  (:start . 135) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 151)\n  (:start . 146) (:id . 61))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 156) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 165)\n  (:start . 157) (:id . 63))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 172)\n  (:start . 166) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 177) (:start . 174)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 189)\n  (:start . 179) (:id . 68))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 200)\n  (:start . 190) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 203) (:start . 201)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 213)\n  (:start . 208) (:id . 72))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 222)\n  (:start . 214) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 226) (:start . 224)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 235)\n  (:start . 227) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 237) (:start . 236)\n  (:id . 77))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 244)\n  (:start . 238) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s154.9) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001403@unknown@formal@none@1@S@DNA band-shift analysis reveals NF-kappa B binding activity in glial cells that differs from that present in T lymphoid cells.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "band-shift") (:form . "band-shift") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s154.10) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001404@unknown@formal@none@1@S@Further, we observe that TAR-deleted mutants of HIV-1 demonstrate normal late gene expression in glial cells as evidenced by syncytia formation and production of viral p24 antigen.(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "observe") (:form . "observe") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tar-deleted") (:form . "TAR-deleted") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "syncytia") (:form . "syncytia") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "antigen.(ABSTRACT") (:form . "antigen.(ABSTRACT")\n  (:end . 189) (:start . 172) (:id . 69))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 199)\n  (:start . 190) (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 206) (:start . 203)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 212)\n  (:start . 207) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s154.11) (:did . :|92371447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001405@unknown@formal@none@1@S@Bcl-2: a repressor of lymphocyte death.@(((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 18)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s155.1) (:did . :|92378748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001406@unknown@formal@none@1@S@The genes and mechanisms that control programmed cell death are currently the subject of intense study.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "subject") (:form . "subject") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intense") (:form . "intense") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s155.2) (:did . :|92378748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001407@unknown@formal@none@1@S@The bcl-2 gene, a repressor of lymphocyte death, is perhaps the best understood of the programmed cell death associated genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "understood") (:form . "understood") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "JJ") (:stem . "associated") (:form . "associated") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x155.3.1) (:span 52 59)))\n (:hscopes ((:id . :x155.3.1) (:span 0 125)))\n (:identifiers (:sid . :s155.3) (:did . :|92378748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001408@unknown@formal@none@1@S@Here, Stanley Korsmeyer provides a brief overview of bcl-2, concentrating on its roles in B- and T-cell development and in oncogenesis.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Stanley") (:form . "Stanley") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "Korsmeyer") (:form . "Korsmeyer") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "brief") (:form . "brief") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "overview") (:form . "overview") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "concentrate") (:form . "concentrating") (:end . 73)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B-") (:form . "B-") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 134)\n  (:start . 123) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s155.4) (:did . :|92378748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001410@unknown@formal@none@1@S@We have analysed the effect of mitogenic lectins on c-Fos and c-Jun protein levels as well as on activator protein-1 (AP-1) binding and enhancer activity in Jurkat T-cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "lectin") (:form . "lectins") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 131)\n  (:start . 124) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 153)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 163)\n  (:start . 157) (:id . 70))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 171)\n  (:start . 164) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s156.2) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001411@unknown@formal@none@1@S@Both c-Fos and c-Jun protein levels were increased after Con A and PHA stimulation.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "con") (:form . "Con") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s156.3) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001412@unknown@formal@none@1@S@Since T-cell stimulation increases both intracellular Ca2+ and cAMP levels and activates protein kinase C (PKC), the possible involvement of these intracellular messengers in c-Fos and c-Jun induction was tested.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 53) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 160) (:start . 147) (:id . 66))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 171)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 180)\n  (:start . 175) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 200)\n  (:start . 191) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 211)\n  (:start . 205) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x156.4.1) (:span 117 125)))\n (:hscopes ((:id . :x156.4.1) (:span 117 200)))\n (:identifiers (:sid . :s156.4) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001413@unknown@formal@none@1@S@PMA, which directly activates PKC, mimicked the effect of the lectins on c-Fos and c-Jun, but elevation of either intracellular Ca2+ or cAMP levels had little or no effect.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "mimic") (:form . "mimicked") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lectin") (:form . "lectins") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 103)\n  (:start . 94) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 113)\n  (:start . 107) (:id . 63))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 127) (:start . 114) (:id . 64))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 147)\n  (:start . 141) (:id . 68))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 158)\n  (:start . 152) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 171)\n  (:start . 165) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x156.5.1) (:span 162 164)))\n (:nscopes ((:id . :x156.5.1) (:span 162 171)))\n (:identifiers (:sid . :s156.5) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001414@unknown@formal@none@1@S@The mitogen-induced increase of c-Fos and c-Jun immunoreactivity was inhibited by H-7, a kinase inhibitor with relatively high specificity for PKC, and less efficiently by H-8, a structurally related kinase inhibitor less active on PKC, but more active on cyclic nucleotide-dependent kinases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mitogen-induced") (:form . "mitogen-induced")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunoreactivity") (:form . "immunoreactivity")\n  (:end . 64) (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "H-7") (:form . "H-7") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 138)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 168)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "h-8") (:form . "H-8") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 191)\n  (:start . 179) (:id . 72))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 199)\n  (:start . 192) (:id . 73))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 206)\n  (:start . 200) (:id . 74))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 216)\n  (:start . 207) (:id . 75))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 221) (:start . 217)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 228)\n  (:start . 222) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 231) (:start . 229)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 235) (:start . 232)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 236) (:start . 235)\n  (:id . 80))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 240) (:start . 237)\n  (:id . 81))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 245) (:start . 241)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 252)\n  (:start . 246) (:id . 83))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 255) (:start . 253)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 262)\n  (:start . 256) (:id . 85))\n ((:tag . "JJ") (:stem . "nucleotide-dependent")\n  (:form . "nucleotide-dependent") (:end . 283) (:start . 263) (:id . 86))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 291)\n  (:start . 284) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s156.6) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001415@unknown@formal@none@1@S@Con A stimulation was found to increase both binding of AP-1 to the AP-1 consensus sequence, TRE, and AP-1 enhancer activity, in Jurkat cells.@(((:tag . "NN") (:stem . "con") (:form . "Con") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 115)\n  (:start . 107) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 135)\n  (:start . 129) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s156.7) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001416@unknown@formal@none@1@S@PMA was also found to increase the AP-1 enhancer activity, whereas elevation of Ca2+ or cAMP had only minor effects.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ca2+") (:form . "Ca2+") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s156.8) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001417@unknown@formal@none@1@S@We conclude that stimulation with mitogenic lectins is sufficient to increase both c-Fos and c-Jun protein levels, AP-1 binding and AP-1 enhancer activity in Jurkat cells and that they act via mechanisms that could involve the activation of PKC.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "lectin") (:form . "lectins") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 203)\n  (:start . 193) (:id . 74))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 214)\n  (:start . 209) (:id . 76))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 222)\n  (:start . 215) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 78))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 237)\n  (:start . 227) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 240) (:start . 238)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 244) (:start . 241)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x156.9.1) (:span 209 214)))\n (:hscopes ((:id . :x156.9.1) (:span 209 244)))\n (:identifiers (:sid . :s156.9) (:did . :|92378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001418@unknown@formal@none@1@S@Functional interaction between the two zinc finger domains of the v-erb A oncoprotein.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s157.1) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001420@unknown@formal@none@1@S@The protein expressed by the v-erb A oncogene binds to DNA and acts as a dominant negative inhibitor of both the thyroid hormone receptor and the closely related retinoic acid receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 153)\n  (:start . 146) (:id . 68))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 161)\n  (:start . 154) (:id . 69))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 170)\n  (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 184)\n  (:start . 176) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s157.3) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001421@unknown@formal@none@1@S@The v-erb A protein has sustained two amino acid alterations within its DNA-binding domain relative to that of c-erb A, one of which, at serine 61, is known to be important for v-erb A function in the neoplastic cell.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "sustain") (:form . "sustained") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-erb") (:form . "c-erb") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 143)\n  (:start . 137) (:id . 68))\n ((:tag . "CD") (:stem . "61") (:form . "61") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 156)\n  (:start . 151) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 73))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 162) (:start . 160)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 172)\n  (:start . 163) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 176) (:start . 173)\n  (:id . 76))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 182)\n  (:start . 177) (:id . 77))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 184) (:start . 183)\n  (:id . 78))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 193)\n  (:start . 185) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "neoplastic") (:form . "neoplastic") (:end . 211)\n  (:start . 201) (:id . 82))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s157.4) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001422@unknown@formal@none@1@S@We report here that the second alteration, at threonine 78, also plays an important, although more indirect, role:@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "threonine") (:form . "threonine") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 98) (:start . 94)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 114) (:start . 113)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s157.5) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001423@unknown@formal@none@1@S@alteration of the sequence at threonine 78 such that it resembles that of c-erb A can act as an intragenic suppressor and can partially restore function to a v-erb A protein rendered defective due to a mutation at position 61.@(((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "threonine") (:form . "threonine") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "resemble") (:form . "resembles") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-erb") (:form . "c-erb") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intragenic") (:form . "intragenic") (:end . 106)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 135)\n  (:start . 126) (:id . 65))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 163)\n  (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 173)\n  (:start . 166) (:id . 72))\n ((:tag . "VBD") (:stem . "render") (:form . "rendered") (:end . 182)\n  (:start . 174) (:id . 73))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 192)\n  (:start . 183) (:id . 74))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 201) (:start . 200)\n  (:id . 77))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 210)\n  (:start . 202) (:id . 78))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 213) (:start . 211)\n  (:id . 79))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 222)\n  (:start . 214) (:id . 80))\n ((:tag . "CD") (:stem . "61") (:form . "61") (:end . 225) (:start . 223)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s157.6) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001424@unknown@formal@none@1@S@Threonine 78 lies within the D-box of the v-erb A protein, a region thought to mediate receptor-receptor dimerizations, and is not in physical proximity to the serine at position 61.@(((:tag . "NNP") (:stem . "Threonine") (:form . "Threonine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "d-box") (:form . "D-box") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 67)\n  (:start . 61) (:id . 55))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 75)\n  (:start . 68) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "JJ") (:stem . "receptor-receptor") (:form . "receptor-receptor")\n  (:end . 104) (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "dimerization") (:form . "dimerizations")\n  (:end . 118) (:start . 105) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "proximity") (:form . "proximity") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 178)\n  (:start . 170) (:id . 72))\n ((:tag . "CD") (:stem . "61") (:form . "61") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x157.7.2) (:span 68 75)))\n (:ncues ((:id . :x157.7.1) (:span 127 130)))\n (:hscopes ((:id . :x157.7.2) (:span 59 118)))\n (:nscopes ((:id . :x157.7.1) (:span 127 181)))\n (:identifiers (:sid . :s157.7) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001425@unknown@formal@none@1@S@It therefore appears that an indirect interaction occurs between these two sites and that this interaction is crucial for v-erb A function.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 106)\n  (:start . 95) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "v-erb") (:form . "v-erb") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x157.8.1) (:span 13 20)))\n (:hscopes ((:id . :x157.8.1) (:span 13 138)))\n (:identifiers (:sid . :s157.8) (:did . :|92385366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001426@unknown@formal@none@1@S@Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.@(((:tag . "NNP") (:stem . "Pax-5") (:form . "Pax-5") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "cns") (:form . "CNS") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "testis") (:form . "testis") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s158.1) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001427@unknown@formal@none@1@S@BSAP has been identified previously as a transcription factor that is expressed at early, but not late, stages of B-cell differentiation.@(((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 136) (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x158.2.1) (:span 94 97)))\n (:nscopes ((:id . :x158.2.1) (:span 94 102)))\n (:identifiers (:sid . :s158.2) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001428@unknown@formal@none@1@S@Biochemical purification and cDNA cloning has now revealed that BSAP belongs to the family of paired domain proteins.@(((:tag . "JJ") (:stem . "biochemical") (:form . "Biochemical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s158.3) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001430@unknown@formal@none@1@S@An intact paired domain was shown to be both necessary and sufficient for DNA binding of BSAP.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s158.5) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001431@unknown@formal@none@1@S@Binding studies with several BSAP recognition sequences demonstrated that the sequence specificity of BSAP differs from that of the distantly related paired domain protein Pax-1.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 68)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 98)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 114)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "RB") (:stem . "distantly") (:form . "distantly") (:end . 141)\n  (:start . 132) (:id . 61))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 163)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 171)\n  (:start . 164) (:id . 65))\n ((:tag . "NN") (:stem . "pax-1") (:form . "Pax-1") (:end . 177)\n  (:start . 172) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s158.6) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001432@unknown@formal@none@1@S@During embryogenesis, the BSAP gene is transiently expressed in the mesencephalon and spinal cord with a spatial and temporal expression pattern that is distinct from that of other Pax genes in the developing central nervous system (CNS).@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "embryogenesis") (:form . "embryogenesis")\n  (:end . 20) (:start . 7) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mesencephalon") (:form . "mesencephalon")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "spinal") (:form . "spinal") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "spatial") (:form . "spatial") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 161)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . "NNP") (:stem . "Pax") (:form . "Pax") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 190)\n  (:start . 185) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 208)\n  (:start . 198) (:id . 75))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 216)\n  (:start . 209) (:id . 76))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 224)\n  (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cns") (:form . "CNS") (:end . 236) (:start . 233)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 237) (:start . 236)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s158.7) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001433@unknown@formal@none@1@S@Later, the expression of the BSAP gene shifts to the fetal liver where it correlates with the onset of B lymphopoiesis.@(((:tag . "RB") (:stem . "later") (:form . "Later") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "shift") (:form . "shifts") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 84)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphopoiesis") (:form . "lymphopoiesis")\n  (:end . 118) (:start . 105) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s158.8) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001434@unknown@formal@none@1@S@BSAP expression persists in B lymphocytes and is also seen in the testis of the adult mouse.@(((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "persist") (:form . "persists") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "testis") (:form . "testis") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s158.9) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001435@unknown@formal@none@1@S@All of this evidence indicates that the transcription factor BSAP may not only play an important role in B-cell differentiation but also in neural development and spermatogenesis.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 127) (:start . 112) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "neural") (:form . "neural") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "spermatogenesis") (:form . "spermatogenesis")\n  (:end . 178) (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x158.10.1) (:span 66 69))\n  ((:id . :x158.10.2) (:span 21 35)))\n (:hscopes ((:id . :x158.10.1) (:span 66 178))\n  ((:id . :x158.10.2) (:span 21 178)))\n (:identifiers (:sid . :s158.10) (:did . :|92387536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001436@unknown@formal@none@1@S@Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes.@(((:tag . "JJ") (:stem . "okadaic") (:form . "Okadaic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 72)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 85)\n  (:start . 73) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 108)\n  (:start . 97) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s159.1) (:did . :|92392375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001437@unknown@formal@none@1@S@Treatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-kappa B levels.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 108)\n  (:start . 96) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 144)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 165) (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 172)\n  (:start . 166) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 178) (:start . 174)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 191)\n  (:start . 185) (:id . 75))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 200)\n  (:start . 192) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 212)\n  (:start . 204) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 214) (:start . 213)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 221)\n  (:start . 215) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s159.2) (:did . :|92392375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001438@unknown@formal@none@1@S@In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 36)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 51)\n  (:start . 44) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 90) (:start . 86)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 96) (:start . 91)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x159.3.1) (:span 13 15)))\n (:nscopes ((:id . :x159.3.1) (:span 13 84)))\n (:identifiers (:sid . :s159.3) (:did . :|92392375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001440@unknown@formal@none@1@S@Treatment with okadaic acid resulted in a striking increase in TNF-alpha mRNA transcripts within 1 h of stimulation and large amounts of TNF-alpha were released into the culture media.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 146)\n  (:start . 137) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s159.5) (:did . :|92392375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001441@unknown@formal@none@1@S@Although okadaic acid provides a potent inductive signal for AP-1 and NF-kappa B it did not induce either B cell proliferation or immunoglobulin secretion.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "inductive") (:form . "inductive") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 126) (:start . 113) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 144) (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x159.6.1) (:span 88 91)))\n (:nscopes ((:id . :x159.6.1) (:span 88 154)))\n (:identifiers (:sid . :s159.6) (:did . :|92392375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001442@unknown@formal@none@1@S@A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "Ets-related") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 80) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "JJ") (:stem . "trans") (:form . "trans") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 167) (:start . 166)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s160.1) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001443@unknown@formal@none@1@S@Human immunodeficiency virus type 1 (HIV-1) and HIV-2 are structurally related retroviruses which both cause AIDS in humans.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-2") (:form . "HIV-2") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "retrovirus") (:form . "retroviruses") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s160.2) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001444@unknown@formal@none@1@S@Although both viruses establish latency in quiescent human-peripheral-blood T cells, the asymptomatic phase of HIV-2 infection may be more prolonged than that of HIV-1.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "human-peripheral-blood")\n  (:form . "human-peripheral-blood") (:end . 75) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "asymptomatic") (:form . "asymptomatic") (:end . 101)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 167)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x160.3.1) (:span 127 130)))\n (:hscopes ((:id . :x160.3.1) (:span 127 167)))\n (:identifiers (:sid . :s160.3) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001445@unknown@formal@none@1@S@The latent phases of both HIV-1 and HIV-2 infection have been shown to be disrupted by T-cell activation, a process that requires host cell transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "disrupt") (:form . "disrupted") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s160.4) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001446@unknown@formal@none@1@S@In the case of HIV-1, the transcription factor NF-kappa B is sufficient for inducible transcriptional activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s160.5) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001447@unknown@formal@none@1@S@In contrast, factors in addition to NF-kappa B are required to activate HIV-2 transcription in infected T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s160.6) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001448@unknown@formal@none@1@S@In this report, we demonstrate that a novel Ets-related transcription factor, Elf-1, binds specifically to two purine-rich motifs in the HIV-2 enhancer.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "Ets-related") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 122)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s160.7) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001450@unknown@formal@none@1@S@Moreover, Elf-1 is the only factor present in activated T-cell nuclear extracts that binds to these sites in electrophoretic mobility shift assays.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 124) (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s160.9) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001451@unknown@formal@none@1@S@Thus, Elf-1 is a novel transcription factor that appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "t-cell-receptor-mediated")\n  (:form . "T-cell-receptor-mediated") (:end . 104) (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "trans") (:form . "trans") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x160.10.1) (:span 49 56)))\n (:hscopes ((:id . :x160.10.1) (:span 44 146)))\n (:identifiers (:sid . :s160.10) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001452@unknown@formal@none@1@S@These results may explain differences in the clinical spectra of diseases caused by HIV-1 and HIV-2 and may also have implications for the design of therapeutic approaches to HIV-2 infection.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "spectrum") (:form . "spectra") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-2") (:form . "HIV-2") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 130)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 160)\n  (:start . 149) (:id . 67))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 171)\n  (:start . 161) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 190)\n  (:start . 181) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x160.11.1) (:span 104 107))\n  ((:id . :x160.11.2) (:span 14 17)))\n (:hscopes ((:id . :x160.11.1) (:span 104 190))\n  ((:id . :x160.11.2) (:span 14 99)))\n (:identifiers (:sid . :s160.11) (:did . :|92407982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001453@unknown@formal@none@1@S@Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nef") (:form . "Nef") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s161.1) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5001455@unknown@formal@none@1@S@Production of HIV-1 from latently infected cells requires host cell activation by T-cell mitogens (T.Folks, D.M.Powell, M.M.Lightfoote, S.Benn, M.A. Martin, and A.S.Fauci, Science 231 : 600-602, 1986; D.Zagury, J. Bernard, R.Leonard, R.Cheynier, M.Feldman, P.S.Sarin, and R.C. Gallo, Science 231 : 850-853, 1986).@(((:tag . "NN") (:stem . "production") (:form . "Production") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . 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5001456@unknown@formal@none@1@S@This activation is mediated by the host transcription factor NF-kappa B [G.Nabel and D.Baltimore, Nature ( London ) 326 : 711-717, 1987].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "G.Nabel") (:form . "G.Nabel") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D.Baltimore") (:form . "D.Baltimore") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Nature") (:form . "Nature") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "London") (:form . "London") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "CD") (:stem . "326") (:form . "326") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "CD") (:stem . "711-717") (:form . "711-717") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1987") (:form . "1987") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s161.4) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001457@unknown@formal@none@1@S@We report here that the HIV-1-encoded Nef protein inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hiv-1-encoded") (:form . "HIV-1-encoded")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "nef") (:form . "Nef") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 98)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s161.5) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001458@unknown@formal@none@1@S@However, Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "sp-1") (:form . "SP-1") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "USF") (:form . "USF") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "URS") (:form . "URS") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x161.6.1) (:span 18 21)))\n (:nscopes ((:id . :x161.6.1) (:span 18 152)))\n (:identifiers (:sid . :s161.6) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001460@unknown@formal@none@1@S@These results indicate that defective recruitment of NF-kappa B may underlie Nef 's negative transcriptional effects on the HIV-1 and interleukin 2 promoters.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 108) (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 145)\n  (:start . 134) (:id . 62))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 157)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x161.8.1) (:span 64 67)) ((:id . :x161.8.2) (:span 14 27)))\n (:hscopes ((:id . :x161.8.1) (:span 64 157))\n  ((:id . :x161.8.2) (:span 14 157)))\n (:identifiers (:sid . :s161.8) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001461@unknown@formal@none@1@S@Further evidence suggests that Nef inhibits NF-kappa B induction by interfering with a signal derived from the T-cell receptor complex.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x161.9.1) (:span 17 25)))\n (:hscopes ((:id . :x161.9.1) (:span 17 134)))\n (:identifiers (:sid . :s161.9) (:did . :|92408021|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001462@unknown@formal@none@1@S@[Effect of antihypertensive therapy with captopril on gluco- and mineralocorticoid receptors of peripheral blood lymphocytes in hypertensive patients of various age]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "Effect") (:end . 7) (:start . 1)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antihypertensive") (:form . "antihypertensive")\n  (:end . 27) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "captopril") (:form . "captopril") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gluco-") (:form . "gluco-") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 82) (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 124)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "hypertensive") (:form . "hypertensive") (:end . 140)\n  (:start . 128) (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 149)\n  (:start . 141) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 160)\n  (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 164) (:start . 161)\n  (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 165) (:start . 164)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s162.1) (:did . :|92408125|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001463@unknown@formal@none@1@S@Binding of 3H-dexamethasone and 3H-aldosterone by peripheral lymphocyte receptors was investigated in healthy persons and hypertensive patients before and after 2-week captopril treatment.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "3H-dexamethasone") (:form . "3H-dexamethasone")\n  (:end . 27) (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "3H-aldosterone") (:form . "3H-aldosterone")\n  (:end . 46) (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 81)\n  (:start . 72) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 98)\n  (:start . 86) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 109)\n  (:start . 102) (:id . 54))\n ((:tag . "NNS") (:stem . "person") (:form . "persons") (:end . 117)\n  (:start . 110) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hypertensive") (:form . "hypertensive") (:end . 134)\n  (:start . 122) (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 143)\n  (:start . 135) (:id . 58))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 150)\n  (:start . 144) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 160)\n  (:start . 155) (:id . 61))\n ((:tag . "JJ") (:stem . "2-week") (:form . "2-week") (:end . 167)\n  (:start . 161) (:id . 62))\n ((:tag . "NN") (:stem . "captopril") (:form . "captopril") (:end . 177)\n  (:start . 168) (:id . 63))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 187)\n  (:start . 178) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s162.2) (:did . :|92408125|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001464@unknown@formal@none@1@S@The number of glucocorticoid and mineralocorticoid binding sites was increased in hypertensives vs normotensives.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 50) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "hypertensive") (:form . "hypertensives")\n  (:end . 95) (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "vs") (:form . "vs") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "normotensive") (:form . "normotensives")\n  (:end . 112) (:start . 99) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s162.3) (:did . :|92408125|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001465@unknown@formal@none@1@S@The treatment with the ACE inhibitor captopril led to activation of hormone-receptor interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ACE") (:form . "ACE") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "captopril") (:form . "captopril") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hormone-receptor") (:form . "hormone-receptor")\n  (:end . 84) (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 97)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s162.4) (:did . :|92408125|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001466@unknown@formal@none@1@S@There was a more marked rise of the number of receptors in middle-aged (44-55 years) hypertensives vs elderly (61-80 years) subjects after captopril treatment.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 55)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "middle-aged") (:form . "middle-aged") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "CD") (:stem . "44-55") (:form . "44-55") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "hypertensive") (:form . "hypertensives")\n  (:end . 98) (:start . 85) (:id . 59))\n ((:tag . "CC") (:stem . "vs") (:form . "vs") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "CD") (:stem . "61-80") (:form . "61-80") (:end . 116)\n  (:start . 111) (:id . 63))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 132)\n  (:start . 124) (:id . 66))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "captopril") (:form . "captopril") (:end . 148)\n  (:start . 139) (:id . 68))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 158)\n  (:start . 149) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s162.5) (:did . :|92408125|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001467@unknown@formal@none@1@S@Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6.@(((:tag . "NNP") (:stem . "Leukotriene") (:form . "Leukotriene") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B4") (:form . "B4") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 32) (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 42)\n  (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 56) (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 47))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 77)\n  (:start . 68) (:id . 48))\n ((:tag . "NNP") (:stem . "NK-chi") (:form . "NK-chi") (:end . 84)\n  (:start . 78) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 97)\n  (:start . 91) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s163.1) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001468@unknown@formal@none@1@S@Leukotriene B4 (LTB4) is a notable participant in inflammation and chemotaxis.@(((:tag . "NNP") (:stem . "Leukotriene") (:form . "Leukotriene") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B4") (:form . "B4") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "notable") (:form . "notable") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "participant") (:form . "participant") (:end . 46)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 62)\n  (:start . 50) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chemotaxis") (:form . "chemotaxis") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s163.2) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001470@unknown@formal@none@1@S@Here we report that LTB4 induces synthesis of interleukin (IL)-6 by human blood monocytes through transcriptional activation of the IL-6 gene.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "IL)-6") (:form . "IL)-6") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 113) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s163.4) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001471@unknown@formal@none@1@S@We furthermore demonstrate that this process involves activation of the transcription factor NF-chi B and, to a lesser extent, of NF-IL6, while the activity of the transcription factor AP-1, shown to otherwise confer IL-6 inducibility, appeared to be unaffected by LTB4.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "furthermore") (:form . "furthermore") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . 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5001472@unknown@formal@none@1@S@Involvement of NF-chi B and NF-IL6 in induction of IL-6 transcription by monocytes was demonstrated using deleted forms of the IL-6 promoter.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 105) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "deleted") (:form . "deleted") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s163.6) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001473@unknown@formal@none@1@S@Activation of the IL-6 promoter by LTB4 was not only associated with accumulation of the respective transcripts but resulted in synthesis of functional IL-6 protein as well.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 81)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 151)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s163.7) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001474@unknown@formal@none@1@S@In addition, LTB4 mediated transactivation of a heterologous promoter construct containing the NF-chi B or the NF-IL6 enhancer, but not the AP-1 enhancer.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LTB4") (:form . "LTB4") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 42) (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x163.8.1) (:span 132 135)))\n (:nscopes ((:id . :x163.8.1) (:span 132 153)))\n (:identifiers (:sid . :s163.8) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001475@unknown@formal@none@1@S@The signaling events mediating this effect appeared to involve the release of H2O2, since LTB4 failed to induce NF-chi B or NF-IL6 in the presence of the scavenger of H2O2, N-acetyl-L-cysteine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 163)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 192) (:start . 173) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x163.9.2) (:span 43 51)))\n (:ncues ((:id . :x163.9.1) (:span 95 101)))\n (:hscopes ((:id . :x163.9.2) (:span 0 82)))\n (:nscopes ((:id . :x163.9.1) (:span 95 192)))\n (:identifiers (:sid . :s163.9) (:did . :|93011470|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001476@unknown@formal@none@1@S@Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro.@(((:tag . "NNP") (:stem . "Estrogen") (:form . "Estrogen") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "danazol") (:form . "danazol") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 84)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s164.1) (:did . :|93012816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001477@unknown@formal@none@1@S@1 . This study was designed to investigate the presence of estrogen type I (high affinity, low capacity) and type II (low affinity, high capacity) binding sites in human peripheral blood monocytes and the effects of danazol on these sites.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "This") (:end . 8) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 42)\n  (:start . 31) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 113) (:start . 109)\n  (:id . 64))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 116) (:start . 114)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 121) (:start . 118)\n  (:id . 67))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 130)\n  (:start . 122) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 136) (:start . 132)\n  (:id . 70))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 145)\n  (:start . 137) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 72))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 154)\n  (:start . 147) (:id . 73))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 160)\n  (:start . 155) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 169)\n  (:start . 164) (:id . 76))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 180)\n  (:start . 170) (:id . 77))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 186)\n  (:start . 181) (:id . 78))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 196)\n  (:start . 187) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 212)\n  (:start . 205) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 83))\n ((:tag . "NN") (:stem . "danazol") (:form . "danazol") (:end . 223)\n  (:start . 216) (:id . 84))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 226) (:start . 224)\n  (:id . 85))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 232)\n  (:start . 227) (:id . 86))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 238)\n  (:start . 233) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x164.2.1) (:span 31 42)))\n (:hscopes ((:id . :x164.2.1) (:span 31 238)))\n (:identifiers (:sid . :s164.2) (:did . :|93012816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001478@unknown@formal@none@1@S@2 . These two types of estrogen binding sites existed in human peripheral blood monocytes.@(((:tag . "LS") (:stem . "2") (:form . "2") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "These") (:end . 9) (:start . 4)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "exist") (:form . "existed") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s164.3) (:did . :|93012816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001480@unknown@formal@none@1@S@4 . It is suggested that danazol has an anti-estrogenic action to the monocytes through the competition and suppression of estrogen binding sites as seen in the estrogen target organ.@(((:tag . "LS") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 6) (:start . 4)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 19)\n  (:start . 10) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "danazol") (:form . "danazol") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-estrogenic") (:form . "anti-estrogenic")\n  (:end . 55) (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 119)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 182)\n  (:start . 177) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x164.5.1) (:span 10 19)))\n (:hscopes ((:id . :x164.5.1) (:span 10 145)))\n (:identifiers (:sid . :s164.5) (:did . :|93012816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001481@unknown@formal@none@1@S@[Mechanism of action of steroid hormones . I . Estrogens]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "Mechanism") (:end . 10)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "i") (:form . "I") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Estrogen") (:form . "Estrogens") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 57) (:start . 56)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s165.1) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001482@unknown@formal@none@1@S@The steroid hormone are very versatile molecules:@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "versatile") (:form . "versatile") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s165.2) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001483@unknown@formal@none@1@S@although they are related among them by their chemical structure, they have very diverse functions and including antagonic.@(((:tag . "IN") (:stem . "although") (:form . "although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 45)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "chemical") (:form . "chemical") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "JJ") (:stem . "antagonic") (:form . "antagonic") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s165.3) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001484@unknown@formal@none@1@S@Their action mechanism is not completely cleared.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "clear") (:form . "cleared") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x165.4.1) (:span 26 29)))\n (:nscopes ((:id . :x165.4.1) (:span 26 48)))\n (:identifiers (:sid . :s165.4) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001485@unknown@formal@none@1@S@The estrogens participate in the regulation of practically all the reproductive and sexual events of the female, although the intracellular actions by which they take place are not well known and the proposed models do not adequately satisfy the questions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "estrogen") (:form . "estrogens") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "practically") (:form . "practically") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "reproductive") (:form . "reproductive") (:end . 79)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sexual") (:form . "sexual") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "female") (:form . "female") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 156)\n  (:start . 151) (:id . 65))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "take") (:form . "take") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 185) (:start . 181)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 191)\n  (:start . 186) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 208)\n  (:start . 200) (:id . 75))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 215)\n  (:start . 209) (:id . 76))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . "RB") (:stem . "adequately") (:form . "adequately") (:end . 233)\n  (:start . 223) (:id . 79))\n ((:tag . "VB") (:stem . "satisfy") (:form . "satisfy") (:end . 241)\n  (:start . 234) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "question") (:form . "questions") (:end . 255)\n  (:start . 246) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x165.5.1) (:span 219 222))\n  ((:id . :x165.5.2) (:span 177 180)))\n (:nscopes ((:id . :x165.5.1) (:span 219 255))\n  ((:id . :x165.5.2) (:span 177 191)))\n (:identifiers (:sid . :s165.5) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001486@unknown@formal@none@1@S@Currently it is accepted the existence of a cytoplasmic and/or nuclear receptor, without explaining satisfactorily how the hormones come to the nucleus.@(((:tag . "RB") (:stem . "currently") (:form . "Currently") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accept") (:form . "accepted") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "VBG") (:stem . "explain") (:form . "explaining") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "RB") (:stem . "satisfactorily") (:form . "satisfactorily")\n  (:end . 114) (:start . 100) (:id . 57))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "VBP") (:stem . "come") (:form . "come") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x165.6.1) (:span 81 88)))\n (:nscopes ((:id . :x165.6.1) (:span 81 151)))\n (:identifiers (:sid . :s165.6) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001487@unknown@formal@none@1@S@The endocrine events that are rapidly expressed (seconds) are due to a possible interaction with cellular membrane.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "second") (:form . "seconds") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 91)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x165.7.1) (:span 71 79)))\n (:hscopes ((:id . :x165.7.1) (:span 71 114)))\n (:identifiers (:sid . :s165.7) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001488@unknown@formal@none@1@S@The purpose of this review is to analyze and concilliate the reported data on the mechanism of action of estrogens.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "VB") (:stem . "concilliate") (:form . "concilliate") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "estrogen") (:form . "estrogens") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s165.8) (:did . :|93013114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001490@unknown@formal@none@1@S@The human immunodeficiency virus (HIV) Rev protein is essential for viral structural protein expression (Gag, Pol, and Env) and , hence , for viral replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 26) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Gag") (:form . "Gag") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Pol") (:form . "Pol") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Env") (:form . "Env") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 147)\n  (:start . 142) (:id . 71))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 159)\n  (:start . 148) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s166.2) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001491@unknown@formal@none@1@S@In transient transfection assays, mutant forms of Rev have been identified that inhibit wild-type Rev activity and therefore suppress viral replication.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 151)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s166.3) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001492@unknown@formal@none@1@S@To determine whether such transdominant Rev proteins could provide long-term protection against HIV infection without affecting T cell function, T leukemia cell lines were stably transduced with a retroviral vector encoding a transdominant mutant of the Rev protein, M10.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transdominant") (:form . "transdominant")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 117)\n  (:start . 110) (:id . 56))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 127)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 155)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 178)\n  (:start . 172) (:id . 67))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 189)\n  (:start . 179) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 194) (:start . 190)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 207)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 214)\n  (:start . 208) (:id . 72))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 223)\n  (:start . 215) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 225) (:start . 224)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "transdominant") (:form . "transdominant")\n  (:end . 239) (:start . 226) (:id . 75))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 246)\n  (:start . 240) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 249) (:start . 247)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 253) (:start . 250)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 257) (:start . 254)\n  (:id . 79))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 265)\n  (:start . 258) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 266) (:start . 265)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "M10") (:form . "M10") (:end . 270) (:start . 267)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x166.4.2) (:span 53 58)) ((:id . :x166.4.3) (:span 13 20)))\n (:ncues ((:id . :x166.4.1) (:span 110 117)))\n (:hscopes ((:id . :x166.4.2) (:span 53 143))\n  ((:id . :x166.4.3) (:span 13 143)))\n (:nscopes ((:id . :x166.4.1) (:span 110 143)))\n (:identifiers (:sid . :s166.4) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001493@unknown@formal@none@1@S@While all the M10-expressing cell lines remained infectable by HIV-1, these same cells failed to support a productive replication cycle when infected with a cloned isolate of HIV-1.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "m10-expressing") (:form . "M10-expressing")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "infectable") (:form . "infectable") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 93) (:start . 87)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "isolate") (:form . "isolate") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x166.5.1) (:span 87 93)))\n (:nscopes ((:id . :x166.5.1) (:span 87 180)))\n (:identifiers (:sid . :s166.5) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001494@unknown@formal@none@1@S@In addition, two out of three M10-expressing CEM clones were also resistant to highly productive infection by a heterogeneous HIV-1 pool.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "m10-expressing") (:form . "M10-expressing")\n  (:end . 44) (:start . 30) (:id . 49))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 125) (:start . 112) (:id . 61))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "pool") (:form . "pool") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s166.6) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001495@unknown@formal@none@1@S@Expression of M10 did not affect induction of HIV transcription mediated by the kappa B regulatory element or Tat.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "M10") (:form . "M10") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x166.7.1) (:span 22 25)))\n (:nscopes ((:id . :x166.7.1) (:span 22 113)))\n (:identifiers (:sid . :s166.7) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001496@unknown@formal@none@1@S@Importantly, constitutive expression of Rev M10 did not alter the secretion of interleukin 2 in response to mitogen stimulation of EL-4 and Jurkat cells.@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Rev") (:form . "Rev") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "M10") (:form . "M10") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x166.8.1) (:span 52 55)))\n (:nscopes ((:id . :x166.8.1) (:span 52 152)))\n (:identifiers (:sid . :s166.8) (:did . :|93018835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001497@unknown@formal@none@1@S@The inhibition of HIV infection in cells stably expressing a transdominant Rev protein, in the absence of any deleterious effect on T cell function, suggests that such a strategy could provide a therapeutic effect in the T lymphocytes of acquired immunodeficiency syndrome patients.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . 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5001498@unknown@formal@none@1@S@Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nephritis") (:form . "nephritis") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 70)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 109)\n  (:start . 98) (:id . 55))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 131)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 149) (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 157)\n  (:start . 150) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s167.1) (:did . :|93020778|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001500@unknown@formal@none@1@S@Glucocorticoid receptor concentrations in mononuclear leukocytes (MNL) in these patients were comparable with those in both other patients with SLE and healthy persons.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 38) (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 53)\n  (:start . 42) (:id . 46))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 64)\n  (:start . 54) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "NNS") (:stem . "person") (:form . "persons") (:end . 167)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s167.3) (:did . :|93020778|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001501@unknown@formal@none@1@S@Improvement in urinary protein excretion and in disease activity, which was scored according to the SLE Disease Activity Index system of the University of Toronto, closely related to the glucocorticoid receptor concentrations in MNL isolated from the corresponding patients.@(((:tag . "NNP") (:stem . "Improvement") (:form . "Improvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "urinary") (:form . "urinary") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "excretion") (:form . "excretion") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "score") (:form . "scored") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Disease") (:form . "Disease") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "NNP") (:stem . "Activity") (:form . "Activity") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "NNP") (:stem . "Index") (:form . "Index") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "University") (:form . "University") (:end . 151)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Toronto") (:form . "Toronto") (:end . 162)\n  (:start . 155) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 179)\n  (:start . 172) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 201) (:start . 187) (:id . 73))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 225) (:start . 211) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 232) (:start . 229)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 241)\n  (:start . 233) (:id . 78))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 246) (:start . 242)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 264) (:start . 251) (:id . 81))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 273)\n  (:start . 265) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s167.4) (:did . :|93020778|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001502@unknown@formal@none@1@S@In summary, glucocorticoid receptor determination in patients with lupus nephritis may be a predictive clue for assessing responsiveness to glucocorticoid therapy.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 26) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nephritis") (:form . "nephritis") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "clue") (:form . "clue") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "assess") (:form . "assessing") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 136) (:start . 122) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 154) (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 162)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x167.5.1) (:span 83 86)))\n (:hscopes ((:id . :x167.5.1) (:span 83 162)))\n (:identifiers (:sid . :s167.5) (:did . :|93020778|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001503@unknown@formal@none@1@S@Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.@(((:tag . "NN") (:stem . "selection") (:form . "Selection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 136) (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s168.1) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001504@unknown@formal@none@1@S@Analysis of the p50 and p65 subunits of the NF-kappa B transcription factor complex has revealed that both proteins can interact with related DNA sequences through either homo- or heterodimer formation.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "JJ") (:stem . "homo-") (:form . "homo-") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 179) (:start . 177)\n  (:id . 70))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 201)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s168.2) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001505@unknown@formal@none@1@S@In addition, the product of the proto-oncogene c-rel can bind to similar DNA motifs by itself or as a heterodimer with p50 or p65.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 46) (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 113)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s168.3) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001506@unknown@formal@none@1@S@However, these studies have used a limited number of known kappa B DNA motifs, and the question of the optimal DNA sequences preferred by each homodimer has not been addressed.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 110)\n  (:start . 103) (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 124)\n  (:start . 115) (:id . 65))\n ((:tag . "VBN") (:stem . "prefer") (:form . "preferred") (:end . 134)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 152)\n  (:start . 143) (:id . 69))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 160) (:start . 157)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "address") (:form . "addressed") (:end . 175)\n  (:start . 166) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x168.4.1) (:span 157 160)))\n (:nscopes ((:id . :x168.4.1) (:span 83 175)))\n (:identifiers (:sid . :s168.4) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001507@unknown@formal@none@1@S@Using purified recombinant p50, p65, and c-Rel proteins, optimal DNA-binding motifs were selected from a pool of random oligonucleotides.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pool") (:form . "pool") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 136) (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s168.5) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001508@unknown@formal@none@1@S@Alignment of the selected sequences allowed us to predict a consensus sequence for binding of the individual homodimeric Rel-related proteins, and DNA-protein binding analysis of the selected DNA sequences revealed sequence specificity of the proteins.@(((:tag . "NNP") (:stem . "Alignment") (:form . "Alignment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "homodimeric") (:form . "homodimeric") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "Rel-related") (:end . 132)\n  (:start . 121) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 158)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 166)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 175)\n  (:start . 167) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 195) (:start . 192)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 205)\n  (:start . 196) (:id . 71))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 214)\n  (:start . 206) (:id . 72))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 223)\n  (:start . 215) (:id . 73))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 235)\n  (:start . 224) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 242) (:start . 239)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 251)\n  (:start . 243) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s168.6) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001510@unknown@formal@none@1@S@Differential binding affinities were also obtained with p50- and c-Rel-selected sequences.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50-") (:form . "p50-") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-rel-selected") (:form . "c-Rel-selected")\n  (:end . 79) (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s168.8) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001511@unknown@formal@none@1@S@Using either a p50- or p65-selected kappa B motif, which displayed differential binding with respect to the other protein, little to no binding was observed with the heterodimeric NF-kappa B complex.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50-") (:form . "p50-") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "p65-selected") (:form . "p65-selected") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 79)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 156)\n  (:start . 148) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 179) (:start . 166) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 188)\n  (:start . 180) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 190) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 198)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x168.9.1) (:span 133 135)))\n (:nscopes ((:id . :x168.9.1) (:span 133 143)))\n (:identifiers (:sid . :s168.9) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001512@unknown@formal@none@1@S@Similarly, in transfection experiments in which the selective kappa B binding sites were used to drive the expression of a chloramphenicol acetyltransferase reporter construct, the p65- and p50-selected motifs were activated only in the presence of p65 and p50/65 (a chimeric protein with the p50 DNA binding domain and p65 activation domain) expression vectors, respectively, and neither demonstrated a significant response to stimuli that induce NF-kappa B activity.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . 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"to") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 138) (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 156) (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 175)\n  (:start . 166) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p65-") (:form . "p65-") (:end . 185) (:start . 181)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "p50-selected") (:form . "p50-selected") (:end . 202)\n  (:start . 190) (:id . 71))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 209)\n  (:start . 203) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 214) (:start . 210)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 224)\n  (:start . 215) (:id . 74))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 229) (:start . 225)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . 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")") (:end . 342) (:start . 341)\n  (:id . 97))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 353)\n  (:start . 343) (:id . 98))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 361)\n  (:start . 354) (:id . 99))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 362) (:start . 361)\n  (:id . 100))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 375)\n  (:start . 363) (:id . 101))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 376) (:start . 375)\n  (:id . 102))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 380) (:start . 377)\n  (:id . 103))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 388)\n  (:start . 381) (:id . 104))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 401)\n  (:start . 389) (:id . 105))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 403) (:start . 402)\n  (:id . 106))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 415)\n  (:start . 404) (:id . 107))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 424)\n  (:start . 416) (:id . 108))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 427) (:start . 425)\n  (:id . 109))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 435)\n  (:start . 428) (:id . 110))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 440) (:start . 436)\n  (:id . 111))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 447)\n  (:start . 441) (:id . 112))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 456)\n  (:start . 448) (:id . 113))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 458) (:start . 457)\n  (:id . 114))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 467)\n  (:start . 459) (:id . 115))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 468) (:start . 467)\n  (:id . 116)))@@@1@75@((:ncues ((:id . :x168.10.1) (:span 381 388)))\n (:nscopes ((:id . :x168.10.1) (:span 381 467)))\n (:identifiers (:sid . :s168.10) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001513@unknown@formal@none@1@S@These findings demonstrate that interaction of both subunits of the heterodimeric NF-kappa B complex with DNA is required for DNA binding and transcriptional activation and suggest that transcriptional activation mediated by the individual rel-related proteins will differ dramatically, depending on the specific kappa B motifs present.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . 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"is") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 157) (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 168)\n  (:start . 158) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 180)\n  (:start . 173) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 201) (:start . 186) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 212)\n  (:start . 202) (:id . 70))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 221)\n  (:start . 213) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 224) (:start . 222)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 239)\n  (:start . 229) (:id . 74))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "rel-related") (:end . 251)\n  (:start . 240) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 260)\n  (:start . 252) (:id . 76))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 265) (:start . 261)\n  (:id . 77))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 272)\n  (:start . 266) (:id . 78))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 285)\n  (:start . 273) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 286) (:start . 285)\n  (:id . 80))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 296)\n  (:start . 287) (:id . 81))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 299) (:start . 297)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 303) (:start . 300)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 312)\n  (:start . 304) (:id . 84))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 318)\n  (:start . 313) (:id . 85))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 320) (:start . 319)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 327)\n  (:start . 321) (:id . 87))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 335)\n  (:start . 328) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 336) (:start . 335)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x168.11.1) (:span 173 180)))\n (:hscopes ((:id . :x168.11.1) (:span 173 335)))\n (:identifiers (:sid . :s168.11) (:did . :|93024383|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001514@unknown@formal@none@1@S@Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II ( NF-kappa B ) element.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 84)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "TC-II") (:form . "TC-II") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s169.1) (:did . :|93024468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001515@unknown@formal@none@1@S@We have biochemically and functionally characterized a new transcription factor, NP-TCII, which is present in nuclei from unstimulated T and B lymphocytes but is not found in nonhematopoietic cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "biochemically") (:form . "biochemically")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NP-TCII") (:form . "NP-TCII") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 134)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 191) (:start . 175) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x169.2.1) (:span 162 165)))\n (:nscopes ((:id . :x169.2.1) (:span 159 197)))\n (:identifiers (:sid . :s169.2) (:did . :|93024468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001516@unknown@formal@none@1@S@This factor has a DNA-binding specificity similar to that of NF-kappa B but is unrelated to this or other Rel proteins by functional and biochemical criteria.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 148)\n  (:start . 137) (:id . 66))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s169.3) (:did . :|93024468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001517@unknown@formal@none@1@S@It can also be distinguished from other previously described lymphocyte-specific DNA-binding proteins.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "distinguish") (:form . "distinguished") (:end . 28)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 80) (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 92)\n  (:start . 81) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 101)\n  (:start . 93) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s169.4) (:did . :|93024468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001518@unknown@formal@none@1@S@The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "bcl-3") (:form . "Bcl-3") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p50/nf-kappa") (:form . "p50/NF-kappa") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s170.1) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001520@unknown@formal@none@1@S@The protein Bcl-3 contains seven so-called ankyrin repeats.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "bcl-3") (:form . "Bcl-3") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s170.3) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001521@unknown@formal@none@1@S@Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl-3 are most closely related to those found in I kappa B proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF-kappa B activity.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Bcl-3") (:form . "Bcl-3") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 160)\n  (:start . 152) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 169)\n  (:start . 164) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 181)\n  (:start . 174) (:id . 74))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 195)\n  (:start . 189) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 206)\n  (:start . 199) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 79))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 212) (:start . 210)\n  (:id . 80))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 221)\n  (:start . 213) (:id . 81))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 230)\n  (:start . 222) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 83))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 244)\n  (:start . 234) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 247) (:start . 245)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 256)\n  (:start . 248) (:id . 86))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 258) (:start . 257)\n  (:id . 87))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 267)\n  (:start . 259) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x170.4.1) (:span 199 206)))\n (:hscopes ((:id . :x170.4.1) (:span 170 267)))\n (:identifiers (:sid . :s170.4) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001522@unknown@formal@none@1@S@No biological function has yet been described for Bcl-3, but it was noted recently that Bcl-3 interferes with DNA-binding of the p50 subunit of NF-kappa B in vitro.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Bcl-3") (:form . "Bcl-3") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Bcl-3") (:form . "Bcl-3") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 121)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 163)\n  (:start . 158) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x170.5.1) (:span 0 2)))\n (:nscopes ((:id . :x170.5.1) (:span 0 55)))\n (:identifiers (:sid . :s170.5) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001523@unknown@formal@none@1@S@Here we demonstrate that Bcl-3 can aid kappa B site-dependent transcription in vivo by counteracting the inhibitory effects of p50/NF-kappa B homodimers.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-3") (:form . "Bcl-3") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "aid") (:form . "aid") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "site-dependent") (:form . "site-dependent")\n  (:end . 61) (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "counteract") (:form . "counteracting") (:end . 100)\n  (:start . 87) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50/nf-kappa") (:form . "p50/NF-kappa") (:end . 139)\n  (:start . 127) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s170.6) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001524@unknown@formal@none@1@S@Bcl-3 may therefore aid activation of select NF-kappa B-regulated genes, including those of the human immunodeficiency virus.@(((:tag . "NNP") (:stem . "Bcl-3") (:form . "Bcl-3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VB") (:stem . "aid") (:form . "aid") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "select") (:form . "select") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "b-regulated") (:form . "B-regulated") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 118) (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x170.7.1) (:span 6 9)))\n (:hscopes ((:id . :x170.7.1) (:span 6 124)))\n (:identifiers (:sid . :s170.7) (:did . :|93024882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001525@unknown@formal@none@1@S@A microtitre assay system for glucocorticoid receptors: decreased receptor concentration in myocardial infarction.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "microtitre") (:form . "microtitre") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 88) (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "myocardial") (:form . "myocardial") (:end . 102)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "infarction") (:form . "infarction") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s171.1) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001526@unknown@formal@none@1@S@A major difficulty in determination of glucocorticoid receptor sites is the very complicated assay procedure.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "difficulty") (:form . "difficulty") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 53) (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "complicate") (:form . "complicated") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s171.2) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001527@unknown@formal@none@1@S@Therefore, we describe a microtitre assay system for glucocorticoid receptors which is a whole-cell competitive binding radioassay using [3H]-dexamethasone as radioligand.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "microtitre") (:form . "microtitre") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 67) (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "whole-cell") (:form . "whole-cell") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "radioassay") (:form . "radioassay") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 136) (:start . 131)\n  (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "3H]-dexamethasone") (:form . "3H]-dexamethasone")\n  (:end . 155) (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "radioligand") (:form . "radioligand") (:end . 170)\n  (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s171.3) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001528@unknown@formal@none@1@S@This modification of a previously described protocol simplifies and reduces laboratory work and allows assay reproducibility to be controlled more reliably.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "protocol") (:form . "protocol") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBZ") (:stem . "simplify") (:form . "simplifies") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "reproducibility") (:form . "reproducibility")\n  (:end . 124) (:start . 109) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "RB") (:stem . "reliably") (:form . "reliably") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s171.4) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001530@unknown@formal@none@1@S@On the first day of the disease, glucocorticoid receptor capacity was significantly decreased without alteration of the receptor-ligand affinity, whereas on days 4 and 12 the number of receptor sites was normal again.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 47) (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "receptor-ligand") (:form . "receptor-ligand")\n  (:end . 135) (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 153)\n  (:start . 146) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 181)\n  (:start . 175) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 193)\n  (:start . 185) (:id . 72))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 199)\n  (:start . 194) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 203) (:start . 200)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 210)\n  (:start . 204) (:id . 75))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 216)\n  (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x171.6.1) (:span 94 101)))\n (:nscopes ((:id . :x171.6.1) (:span 94 144)))\n (:identifiers (:sid . :s171.6) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001531@unknown@formal@none@1@S@This result fits well into the general observation of stress-induced down-regulation of immune responses.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "fit") (:form . "fits") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "stress-induced") (:form . "stress-induced")\n  (:end . 68) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 84) (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s171.7) (:did . :|93030402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001532@unknown@formal@none@1@S@Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 76) (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s172.1) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001533@unknown@formal@none@1@S@The present work has examined the effects of okadaic acid, an inhibitor of type 1 and 2A protein phosphatases, on the regulation of c-jun expression during monocytic differentiation of U-937 leukemia cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 109)\n  (:start . 97) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 128)\n  (:start . 118) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 155)\n  (:start . 149) (:id . 69))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 165)\n  (:start . 156) (:id . 70))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 181) (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 190)\n  (:start . 185) (:id . 73))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 199)\n  (:start . 191) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 205)\n  (:start . 200) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s172.2) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001534@unknown@formal@none@1@S@The results demonstrate that okadaic acid treatment is associated with induction of a differentiated monocyte phenotype characterized by : ( a ) growth arrest; ( b ) increases in Mac-1 cell surface antigen expression; ( c ) down-regulation of c-myc transcripts; and ( d ) induction of tumor necrosis factor gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . 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"NN") (:stem . "induction") (:form . "induction") (:end . 281)\n  (:start . 272) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 284) (:start . 282)\n  (:id . 91))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 290)\n  (:start . 285) (:id . 92))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 299)\n  (:start . 291) (:id . 93))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 306)\n  (:start . 300) (:id . 94))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 311) (:start . 307)\n  (:id . 95))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 322)\n  (:start . 312) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 323) (:start . 322)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s172.3) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001535@unknown@formal@none@1@S@This induction of monocytic differentiation was associated with transient increases in c-jun mRNA levels, which were maximal at 6 h.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 43) (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 92) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s172.4) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001536@unknown@formal@none@1@S@Similar effects were obtained for the c-fos gene.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s172.5) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001537@unknown@formal@none@1@S@Run-on analysis demonstrated detectable levels of c-jun transcription in U-937 cells and that this rate is increased approximately 40-fold following okadaic acid exposure.@(((:tag . "JJ") (:stem . "run-on") (:form . "Run-on") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 46)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 130) (:start . 117) (:id . 59))\n ((:tag . "RB") (:stem . "40-fold") (:form . "40-fold") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 148)\n  (:start . 139) (:id . 61))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 156)\n  (:start . 149) (:id . 62))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 161) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 170)\n  (:start . 162) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s172.6) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001538@unknown@formal@none@1@S@c-jun mRNA levels were superinduced in cells treated with both okadaic acid and cycloheximide, whereas inhibition of protein synthesis had little, if any, effect on okadaic acid-induced c-jun transcription.@(((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "superinduce") (:form . "superinduced") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 172)\n  (:start . 165) (:id . 70))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 185)\n  (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 191)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 205) (:start . 192) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s172.7) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001540@unknown@formal@none@1@S@In contrast, treatment with both okadaic acid and cycloheximide was associated with stabilization (t 1/2 = 90 min) of c-jun transcripts.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 97) (:start . 84) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "t") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1/2") (:form . "1/2") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 135)\n  (:start . 124) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s172.9) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001541@unknown@formal@none@1@S@Taken together, these findings indicate that the induction of c-jun transcription by okadaic acid is controlled primarily by a transcriptional mechanism.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 142) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x172.10.1) (:span 31 44)))\n (:hscopes ((:id . :x172.10.1) (:span 31 152)))\n (:identifiers (:sid . :s172.10) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001542@unknown@formal@none@1@S@Since previous studies have demonstrated that the c-jun gene is autoinduced by Jun/AP-1, we also studied transcription of c-jun promoter (positions -132/+170)-reporter gene constructs with and without a mutated AP-1 element.(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "autoinduce") (:form . "autoinduced") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "jun/ap-1") (:form . "Jun/AP-1") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "-132/+170)-reporter")\n  (:form . "-132/+170)-reporter") (:end . 167) (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 183)\n  (:start . 173) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 200)\n  (:start . 193) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 210)\n  (:start . 203) (:id . 72))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 215) (:start . 211)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "element.(ABSTRACT") (:form . "element.(ABSTRACT")\n  (:end . 233) (:start . 216) (:id . 74))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 243)\n  (:start . 234) (:id . 75))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 246) (:start . 244)\n  (:id . 76))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 250) (:start . 247)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 256)\n  (:start . 251) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 257) (:start . 256)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x172.11.1) (:span 193 200)))\n (:nscopes ((:id . :x172.11.1) (:span 193 223)))\n (:identifiers (:sid . :s172.11) (:did . :|93041372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001543@unknown@formal@none@1@S@Activation of NF-kappa B by interleukin 2 in human blood monocytes.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s173.1) (:did . :|93041375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001544@unknown@formal@none@1@S@We report here that interleukin 2 (IL-2) acts on human blood monocytes by enhancing binding activity of the transcription factor NF-kappa B to its consensus sequence in the 5' regulatory enhancer region of the IL-2 receptor alpha chain (p55).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 70)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 91)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 165)\n  (:start . 157) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 186)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 195)\n  (:start . 187) (:id . 75))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 202)\n  (:start . 196) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 214) (:start . 210)\n  (:id . 79))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 223)\n  (:start . 215) (:id . 80))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 229)\n  (:start . 224) (:id . 81))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 235)\n  (:start . 230) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 83))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 240) (:start . 237)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 241) (:start . 240)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s173.2) (:did . :|93041375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001545@unknown@formal@none@1@S@Similarly, IL-2 activates NF-kappa B in the human monocytic cell line U 937, but not in resting human T-cells.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "CD") (:stem . "937") (:form . "937") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x173.3.1) (:span 81 84)))\n (:nscopes ((:id . :x173.3.1) (:span 81 109)))\n (:identifiers (:sid . :s173.3) (:did . :|93041375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001546@unknown@formal@none@1@S@This effect is detectable within 15 min and peaks 1 h after exposure to IL-2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "peak") (:form . "peaks") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s173.4) (:did . :|93041375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001547@unknown@formal@none@1@S@Enhanced NF-kappa B binding activity is followed by functional activation in that inducibility of the IL-2 receptor alpha chain is mediated by enhanced NF-kappa B binding and that a heterologous promoter containing the NF-kappa B consensus sequence (-291 to -245) of the IL-2 receptor alpha chain gene is activated.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "follow") (:form . 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5001548@unknown@formal@none@1@S@In addition, IL-2 is capable of increasing transcript levels of the p50 gene coding for the p50 subunit of the NF-kappa B transcription factor, whereas mRNA levels of the p65 NF-kappa B gene remained unchanged.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 83) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 163)\n  (:start . 157) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 174) (:start . 171)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 183)\n  (:start . 175) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 199)\n  (:start . 191) (:id . 77))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 209)\n  (:start . 200) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s173.6) (:did . :|93041375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001550@unknown@formal@none@1@S@A single point assay of glucocorticoid receptors (GR) in human lymphocytes based on the measurement of specific dexamethasone binding has been developed and compared with a common multi-point Scatchard analysis.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 38) (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "measurement") (:form . "measurement") (:end . 99)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 125) (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 179)\n  (:start . 173) (:id . 70))\n ((:tag . "JJ") (:stem . "multi-point") (:form . "multi-point") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "NNP") (:stem . "Scatchard") (:form . "Scatchard") (:end . 201)\n  (:start . 192) (:id . 72))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 210)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s174.2) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001551@unknown@formal@none@1@S@The assay conditions-concentration of the ligand 20 nmol/l, incubation time 2 h and the cell count 2-6 mil. cells/tube in the assay volume 0.25 ml were found to be optimal.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "conditions-concentration")\n  (:form . "conditions-concentration") (:end . 34) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nmol/l") (:form . "nmol/l") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "count") (:form . "count") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2-6") (:form . "2-6") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "CD") (:stem . "mil.") (:form . "mil.") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cells/tube") (:form . "cells/tube") (:end . 118)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "volume") (:form . "volume") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "CD") (:stem . "0.25") (:form . "0.25") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ml") (:form . "ml") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 157)\n  (:start . 152) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 171)\n  (:start . 164) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s174.3) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001552@unknown@formal@none@1@S@An attempt was also undertaken to use a cell harvester for the separation of cells from unbound ligand.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "attempt") (:form . "attempt") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "undertake") (:form . "undertaken") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "harvester") (:form . "harvester") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unbound") (:form . "unbound") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s174.4) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001553@unknown@formal@none@1@S@Though specifically bound dexamethasone measured by whole-cell assay and that using cell harvester correlated well, almost by one order lower values obtained with the latter method render it non-applicable for receptor quantitation.@(((:tag . "IN") (:stem . "though") (:form . "Though") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 39) (:start . 26) (:id . 45))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "whole-cell") (:form . "whole-cell") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "harvester") (:form . "harvester") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 109)\n  (:start . 99) (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 141) (:start . 136)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 180)\n  (:start . 174) (:id . 68))\n ((:tag . "VBP") (:stem . "render") (:form . "render") (:end . 187)\n  (:start . 181) (:id . 69))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "non-applicable") (:form . "non-applicable")\n  (:end . 205) (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 209) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 218)\n  (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "quantitation") (:form . "quantitation") (:end . 231)\n  (:start . 219) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s174.5) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001554@unknown@formal@none@1@S@The results from 9 healthy volunteers (average GR concentration 7131 ± 1256 sites/cell) correlated excellently with those obtained by the Scatchard analysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "CD") (:stem . "7131") (:form . "7131") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1256") (:form . "1256") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sites/cell") (:form . "sites/cell") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "RB") (:stem . "excellently") (:form . "excellently") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Scatchard") (:form . "Scatchard") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s174.6) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001555@unknown@formal@none@1@S@The single point assay has been also applied for determination of GH in 10 children treated with large doses of prednisone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "child") (:form . "children") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "prednisone") (:form . "prednisone") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s174.7) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001556@unknown@formal@none@1@S@The average values from healthy volunteers did not differ significantly from those found in these children, though much broader range was found in patients.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "child") (:form . "children") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "RB") (:stem . "though") (:form . "though") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "broad") (:form . "broader") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x174.8.1) (:span 47 50)))\n (:nscopes ((:id . :x174.8.1) (:span 47 106)))\n (:identifiers (:sid . :s174.8) (:did . :|93043110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001557@unknown@formal@none@1@S@A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-derived") (:form . "cell-derived") (:end . 22)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 79) (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 108) (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 130)\n  (:start . 123) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s175.1) (:did . :|93046624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001558@unknown@formal@none@1@S@A novel B cell-restricted activity, required for high levels of octamer/Oct-dependent transcription from an immunoglobulin heavy chain (IgH) promoter, was detected in an in vitro system consisting of HeLa cell-derived extracts complemented with fractionated B cell nuclear proteins.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-restricted") (:form . "cell-restricted")\n  (:end . 25) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "octamer/oct-dependent")\n  (:form . "octamer/Oct-dependent") (:end . 85) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 99) (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 122) (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 128)\n  (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 196)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "cell-derived") (:form . "cell-derived") (:end . 217)\n  (:start . 205) (:id . 75))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 226)\n  (:start . 218) (:id . 76))\n ((:tag . "VBN") (:stem . "complement") (:form . "complemented") (:end . 239)\n  (:start . 227) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 244) (:start . 240)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "fractionate") (:form . "fractionated") (:end . 257)\n  (:start . 245) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 259) (:start . 258)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 264) (:start . 260)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 272)\n  (:start . 265) (:id . 82))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 281)\n  (:start . 273) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s175.2) (:did . :|93046624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001560@unknown@formal@none@1@S@OCA-B stimulates the transcription from an IgH promoter in conjunction with either Oct-1 or Oct-2 but shows no significant effect on the octamer/Oct-dependent transcription of the ubiquitously expressed histone H2B promoter and the transcription of USF- and Sp1-regulated promoters.@(((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "octamer/oct-dependent")\n  (:form . "octamer/Oct-dependent") (:end . 158) (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 172) (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 192)\n  (:start . 180) (:id . 68))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 202)\n  (:start . 193) (:id . 69))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 210)\n  (:start . 203) (:id . 70))\n ((:tag . "NN") (:stem . "h2b") (:form . "H2B") (:end . 214) (:start . 211)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 223)\n  (:start . 215) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 245) (:start . 232) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 76))\n ((:tag . "NN") (:stem . "usf-") (:form . "USF-") (:end . 253) (:start . 249)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 257) (:start . 254)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "sp1-regulated") (:form . "Sp1-regulated")\n  (:end . 271) (:start . 258) (:id . 79))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 281)\n  (:start . 272) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x175.4.1) (:span 108 110)))\n (:nscopes ((:id . :x175.4.1) (:span 108 281)))\n (:identifiers (:sid . :s175.4) (:did . :|93046624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001561@unknown@formal@none@1@S@Taken together, our results suggest that OCA-B is a tissue-, promoter-, and factor-specific coactivator and that OCA-B may be a major determinant for B cell-specific activation of immunoglobulin promoters.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tissue-") (:form . "tissue-") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter-") (:form . "promoter-") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "factor-specific") (:form . "factor-specific")\n  (:end . 91) (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 145)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 165) (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 194) (:start . 180) (:id . 72))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 204)\n  (:start . 195) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x175.5.1) (:span 119 122))\n  ((:id . :x175.5.2) (:span 28 35)))\n (:hscopes ((:id . :x175.5.1) (:span 119 204))\n  ((:id . :x175.5.2) (:span 28 204)))\n (:identifiers (:sid . :s175.5) (:did . :|93046624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001562@unknown@formal@none@1@S@In light of the evidence showing physical and functional interactions between Oct factors and OCA-B, we propose a mechanism of action for OCA-B and discuss the implications of OCA-B for the transcriptional regulation of other tissue-specific promoters.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 172)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 181)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 205) (:start . 190) (:id . 74))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 216)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 241) (:start . 226) (:id . 78))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 251)\n  (:start . 242) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s175.6) (:did . :|93046624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001563@unknown@formal@none@1@S@The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s176.1) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001564@unknown@formal@none@1@S@The 1311-base pair human tumor necrosis factor ( TNF ) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "1311-base") (:form . "1311-base") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . 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"transient") (:end . 151)\n  (:start . 142) (:id . 69))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 164)\n  (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 171)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 180)\n  (:start . 175) (:id . 73))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 184) (:start . 181)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 194)\n  (:start . 185) (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 199) (:start . 195)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 205)\n  (:start . 200) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 206) (:start . 205)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 79))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 215) (:start . 211)\n  (:id . 80))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 226)\n  (:start . 216) (:id . 81))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 231) (:start . 227)\n  (:id . 82))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 236) (:start . 232)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 237) (:start . 236)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "MLA") (:form . "MLA") (:end . 245) (:start . 242)\n  (:id . 86))\n ((:tag . "CD") (:stem . "144") (:form . "144") (:end . 249) (:start . 246)\n  (:id . 87))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 251) (:start . 250)\n  (:id . 88))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 256) (:start . 252)\n  (:id . 89))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 261) (:start . 257)\n  (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 262) (:start . 261)\n  (:id . 91))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 266) (:start . 263)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 270) (:start . 267)\n  (:id . 93))\n ((:tag . "CD") (:stem . "729-6") (:form . "729-6") (:end . 276)\n  (:start . 271) (:id . 94))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 278) (:start . 277)\n  (:id . 95))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 283) (:start . 279)\n  (:id . 96))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 288) (:start . 284)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 98)))@@@1@57@((:identifiers (:sid . :s176.2) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001565@unknown@formal@none@1@S@This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "13-myristate") (:form . "13-myristate") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s176.3) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001566@unknown@formal@none@1@S@Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "5'-truncation") (:form . "5'-truncations")\n  (:end . 38) (:start . 24) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 45) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "peak") (:form . "peaks") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 161)\n  (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 170)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x176.4.1) (:span 94 104)))\n (:hscopes ((:id . :x176.4.1) (:span 94 170)))\n (:identifiers (:sid . :s176.4) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001567@unknown@formal@none@1@S@A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "CD") (:stem . "-95") (:form . "-95") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "CD") (:stem . "-36") (:form . "-36") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s176.5) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001568@unknown@formal@none@1@S@Within this region, single AP-2- and AP-1-like consensus sequences were noted.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "ap-2-") (:form . "AP-2-") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ap-1-like") (:form . "AP-1-like") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s176.6) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001570@unknown@formal@none@1@S@A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "modest") (:form . "modest") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "20-50") (:form . "20-50") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 27)\n  (:start . 18) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 43)\n  (:start . 35) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 84) (:start . 80)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s176.8) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001571@unknown@formal@none@1@S@However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pma-activated") (:form . "PMA-activated")\n  (:end . 87) (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s176.9) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001572@unknown@formal@none@1@S@Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "co-transfection") (:form . "co-transfections")\n  (:end . 21) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-1/c-jun") (:form . "AP-1/c-jun") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "augmented") (:form . "augmented") (:end . 116)\n  (:start . 107) (:id . 56))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 147)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 156)\n  (:start . 148) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s176.10) (:did . :|93054486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001573@unknown@formal@none@1@S@Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.@(((:tag . "NNP") (:stem . "Redox") (:form . "Redox") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s177.1) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001574@unknown@formal@none@1@S@We have tested the hypothesis that cellular activation events occurring in T lymphocytes and monocytes and mediated through translocation of the transcription factor NF-kappa B are dependent upon the constitutive redox status of these cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 137) (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 158) (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 165)\n  (:start . 159) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 180) (:start . 177)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 190)\n  (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 195) (:start . 191)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 212)\n  (:start . 200) (:id . 71))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 218)\n  (:start . 213) (:id . 72))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 225)\n  (:start . 219) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 74))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 234)\n  (:start . 229) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x177.2.1) (:span 19 29)))\n (:hscopes ((:id . :x177.2.1) (:span 19 240)))\n (:identifiers (:sid . :s177.2) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001575@unknown@formal@none@1@S@We used phenolic, lipid-soluble, chain-breaking antioxidants (butylated hydroxyanisole (BHA), nordihydroquairetic acid, or alpha-tocopherol (vitamin E) to show that peroxyl radical scavenging in unstimulated and PMA- or TNF-stimulated cells blocks the functions depending on NF-kappa B activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "phenolic") (:form . "phenolic") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lipid-soluble") (:form . "lipid-soluble")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "chain-breaking") (:form . "chain-breaking")\n  (:end . 47) (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "butylate") (:form . "butylated") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "hydroxyanisole") (:form . "hydroxyanisole")\n  (:end . 86) (:start . 72) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nordihydroquairetic")\n  (:form . "nordihydroquairetic") (:end . 113) (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . "alpha-tocopherol")\n  (:end . 139) (:start . 123) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 164) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "peroxyl") (:form . "peroxyl") (:end . 172)\n  (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 180)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "scavenging") (:form . "scavenging") (:end . 191)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 207)\n  (:start . 195) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "pma-") (:form . "PMA-") (:end . 216) (:start . 212)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "tnf-stimulated") (:form . "TNF-stimulated")\n  (:end . 234) (:start . 220) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 78))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 247)\n  (:start . 241) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 251) (:start . 248)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 261)\n  (:start . 252) (:id . 81))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 271)\n  (:start . 262) (:id . 82))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 274) (:start . 272)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 283)\n  (:start . 275) (:id . 84))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 285) (:start . 284)\n  (:id . 85))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 296)\n  (:start . 286) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 297) (:start . 296)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s177.3) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001576@unknown@formal@none@1@S@BHA was found to suppress not only PMA- or TNF-induced, but also constitutive, HIV-enhancer activity concomitant to an inhibition of NF-kappa B binding activity in both lymphoblastoid T (J.Jhan) and monocytic (U937) cell lines.@(((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pma-") (:form . "PMA-") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tnf-induced") (:form . "TNF-induced") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 77)\n  (:start . 65) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hiv-enhancer") (:form . "HIV-enhancer") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 112)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 160)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 183) (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "J.Jhan") (:form . "J.Jhan") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 208)\n  (:start . 199) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 77))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 214) (:start . 210)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 220) (:start . 216)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 226)\n  (:start . 221) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s177.4) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001577@unknown@formal@none@1@S@This was also true for KBF (p50 homodimer) binding activity in U937 cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "KBF") (:form . "KBF") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 41)\n  (:start . 32) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s177.5) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001578@unknown@formal@none@1@S@Secretion of TNF, the product of another NF-kappa B-dependent gene, was abolished by BHA in PMA-stimulated U937 cells.@(((:tag . "NNP") (:stem . "Secretion") (:form . "Secretion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pma-stimulated") (:form . "PMA-stimulated")\n  (:end . 106) (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s177.6) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001580@unknown@formal@none@1@S@Oxidative stress obtained by the addition of H2O2 to the culture medium of J.Jhan or U937 cells could not by itself induce NF-kappa B activation.@(((:tag . "JJ") (:stem . "oxidative") (:form . "Oxidative") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "J.Jhan") (:form . "J.Jhan") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x177.8.2) (:span 96 101)))\n (:ncues ((:id . :x177.8.1) (:span 102 105)))\n (:hscopes ((:id . :x177.8.2) (:span 96 144)))\n (:nscopes ((:id . :x177.8.1) (:span 102 144)))\n (:identifiers (:sid . :s177.8) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001581@unknown@formal@none@1@S@These observations suggest that TNF and PMA do not lead to NF-kappa B activation through induction of changes in the cell redox status.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x177.9.2) (:span 19 26)))\n (:ncues ((:id . :x177.9.1) (:span 47 50)))\n (:hscopes ((:id . :x177.9.2) (:span 19 134)))\n (:nscopes ((:id . :x177.9.1) (:span 47 134)))\n (:identifiers (:sid . :s177.9) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001582@unknown@formal@none@1@S@Rather, TNF and PMA can exert their effect only if cells are in an appropriate redox status, because prior modification toward reduction with BHA treatment prevents this activation.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 35)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 78)\n  (:start . 67) (:id . 57))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 91)\n  (:start . 85) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 100)\n  (:start . 93) (:id . 61))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 106)\n  (:start . 101) (:id . 62))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 119)\n  (:start . 107) (:id . 63))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 136)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 155)\n  (:start . 146) (:id . 68))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 164)\n  (:start . 156) (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 180)\n  (:start . 170) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s177.10) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001583@unknown@formal@none@1@S@It appears that a basal redox equilibrium tending toward oxidation is a prerequisite for full activation of transduction pathways regulating the activity of NF-kappa B-dependent genes.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "equilibrium") (:form . "equilibrium") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "VBG") (:stem . "tend") (:form . "tending") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "prerequisite") (:form . "prerequisite") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 120)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 177)\n  (:start . 166) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 183)\n  (:start . 178) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x177.11.1) (:span 3 10)))\n (:hscopes ((:id . :x177.11.1) (:span 3 183)))\n (:identifiers (:sid . :s177.11) (:did . :|93056505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001584@unknown@formal@none@1@S@Expression of c-fos, c-jun and jun B in peripheral blood lymphocytes from young and elderly adults.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 50)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s178.1) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001585@unknown@formal@none@1@S@The expression of c-fos, c-jun and jun B proto-oncogenes was studied in phytohemagglutinin (PHA) activated peripheral blood lymphocytes (PBL) from young and aged humans.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 56) (:start . 41) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 90) (:start . 72) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 135)\n  (:start . 124) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 168)\n  (:start . 162) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s178.2) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001586@unknown@formal@none@1@S@Specific mRNAs for c-fos and c-jun were detectable within 30 min after cell activation and reached maximal levels within 2 h.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "reach") (:form . "reached") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s178.3) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001587@unknown@formal@none@1@S@Both c-fos and jun B mRNAs decreased to pre-activation levels within 6 h, while c-jun mRNA remained elevated.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pre-activation") (:form . "pre-activation")\n  (:end . 54) (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s178.4) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001588@unknown@formal@none@1@S@In PHA-activated PBL, no age-related differences were observed in c-fos or jun B mRNA expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x178.5.1) (:span 22 24)))\n (:nscopes ((:id . :x178.5.1) (:span 0 96)))\n (:identifiers (:sid . :s178.5) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001590@unknown@formal@none@1@S@Because previous work has demonstrated that T cells from elderly individuals may display normal proliferative responses when activated via the anti-CD2 pathway, c-jun and jun B mRNA expression was also studied in anti-CD2-activated purified T cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VB") (:stem . "display") (:form . "display") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 109) (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 159)\n  (:start . 152) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 192)\n  (:start . 182) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 209)\n  (:start . 202) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "anti-cd2-activated") (:form . "anti-CD2-activated")\n  (:end . 231) (:start . 213) (:id . 75))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 240)\n  (:start . 232) (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 242) (:start . 241)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 248)\n  (:start . 243) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x178.7.1) (:span 77 80)))\n (:hscopes ((:id . :x178.7.1) (:span 77 159)))\n (:identifiers (:sid . :s178.7) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001591@unknown@formal@none@1@S@No age-related differences were found in the expression of either of these two proto-oncogenes by anti-CD2 activated T cells.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 94) (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x178.8.1) (:span 59 65)) ((:id . :x178.8.2) (:span 0 2)))\n (:nscopes ((:id . :x178.8.1) (:span 59 94))\n  ((:id . :x178.8.2) (:span 0 124)))\n (:identifiers (:sid . :s178.8) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001592@unknown@formal@none@1@S@These results suggest that the decreased IL-2 production and proliferative response displayed by PHA-activated PBL from elderly adults may be related to age-related changes in c-jun mRNA expression and in the ratio of c-fos to c-jun mRNA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "VBN") (:stem . "display") (:form . "displayed") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 110) (:start . 97) (:id . 55))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 164)\n  (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 172)\n  (:start . 165) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 181)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 186) (:start . 182)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 223)\n  (:start . 218) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 76))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 232)\n  (:start . 227) (:id . 77))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 237) (:start . 233)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x178.9.1) (:span 135 138))\n  ((:id . :x178.9.2) (:span 14 21)))\n (:hscopes ((:id . :x178.9.1) (:span 135 237))\n  ((:id . :x178.9.2) (:span 14 237)))\n (:identifiers (:sid . :s178.9) (:did . :|93061407|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001593@unknown@formal@none@1@S@Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "steroid/thyroid") (:form . "steroid/thyroid")\n  (:end . 97) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 168)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 198) (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 204)\n  (:start . 199) (:id . 70))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 209) (:start . 205)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 218)\n  (:start . 210) (:id . 72))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 225)\n  (:start . 219) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s179.1) (:did . :|93065212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001594@unknown@formal@none@1@S@We have previously identified a T lymphocyte protein which binds to a site within the LTR of the human immunodeficiency virus type 1 (HIV-1) and exerts an inhibitory effect on virus gene expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 119) (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 151)\n  (:start . 145) (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 165)\n  (:start . 155) (:id . 71))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 172)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 181)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s179.2) (:did . :|93065212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001595@unknown@formal@none@1@S@The palindromic site (site B) recognized by this protein is related to the palindromic binding sites of members of the steroid/thyroid hormone receptor family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "palindromic") (:form . "palindromic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "palindromic") (:form . "palindromic") (:end . 86)\n  (:start . 75) (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "steroid/thyroid") (:form . "steroid/thyroid")\n  (:end . 134) (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s179.3) (:did . :|93065212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001596@unknown@formal@none@1@S@Here we characterize the T cell protein binding to this site as a 100 kD protein which is most abundant in T cells and which binds to site B as a 200 kD complex.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "characterize") (:form . "characterize") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 66))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 130)\n  (:start . 125) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 138) (:start . 134)\n  (:id . 69))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 140) (:start . 139)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 143) (:start . 141)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 72))\n ((:tag . "CD") (:stem . "200") (:form . "200") (:end . 149) (:start . 146)\n  (:id . 73))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 152) (:start . 150)\n  (:id . 74))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 160)\n  (:start . 153) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s179.4) (:did . :|93065212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001597@unknown@formal@none@1@S@This protein is distinct from other members of the steroid/thyroid hormone receptor family including the COUP protein which has a closely related DNA binding specificity.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "steroid/thyroid") (:form . "steroid/thyroid")\n  (:end . 66) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "COUP") (:form . "COUP") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 169)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s179.5) (:did . :|93065212|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001598@unknown@formal@none@1@S@A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 63) (:start . 48) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 121)\n  (:start . 113) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 136)\n  (:start . 125) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 157)\n  (:start . 147) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial-leukocyte")\n  (:form . "endothelial-leukocyte") (:end . 182) (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 191)\n  (:start . 183) (:id . 64))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 200)\n  (:start . 192) (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 202) (:start . 201)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 220) (:start . 207) (:id . 68))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 229)\n  (:start . 221) (:id . 69))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 238)\n  (:start . 230) (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 240) (:start . 239)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s180.1) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001600@unknown@formal@none@1@S@The endothelium plays a critical role in inflammation by directing circulating leukocytes into extravascular tissues by expressing adhesive molecules for leukocytes [e.g. , endothelial-leukocyte adhesion molecule 1 (ELAM-1) and intercellular adhesion molecule 1 (ICAM-1)].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 53)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "extravascular") (:form . "extravascular")\n  (:end . 108) (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 116)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 130)\n  (:start . 120) (:id . 58))\n ((:tag . "JJ") (:stem . "adhesive") (:form . "adhesive") (:end . 139)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 149)\n  (:start . 140) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 153) (:start . 150)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 164)\n  (:start . 154) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 166) (:start . 165)\n  (:id . 63))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 170) (:start . 166)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "endothelial-leukocyte")\n  (:form . "endothelial-leukocyte") (:end . 194) (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 203)\n  (:start . 195) (:id . 67))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 212)\n  (:start . 204) (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 214) (:start . 213)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 216) (:start . 215)\n  (:id . 70))\n ((:tag . "NN") (:stem . "elam-1") (:form . "ELAM-1") (:end . 222)\n  (:start . 216) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 241) (:start . 228) (:id . 74))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 250)\n  (:start . 242) (:id . 75))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 259)\n  (:start . 251) (:id . 76))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 261) (:start . 260)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 263) (:start . 262)\n  (:id . 78))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 269)\n  (:start . 263) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 270) (:start . 269)\n  (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 271) (:start . 270)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s180.3) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001601@unknown@formal@none@1@S@We therefore determined whether corticosteroids suppress inflammation by inhibiting endothelial expression of adhesion molecules for neutrophils (polymorphonuclear leukocytes).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 47) (:start . 32) (:id . 46))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 69)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 83)\n  (:start . 73) (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 95)\n  (:start . 84) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 118)\n  (:start . 110) (:id . 54))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 128)\n  (:start . 119) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 132) (:start . 129)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 144)\n  (:start . 133) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 163) (:start . 146) (:id . 59))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 174)\n  (:start . 164) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x180.4.1) (:span 24 31)))\n (:hscopes ((:id . :x180.4.1) (:span 24 175)))\n (:identifiers (:sid . :s180.4) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001602@unknown@formal@none@1@S@Preincubation of endothelial cells with endotoxin [lipopolysaccharide (LPS), 1 microgram/ml] led to a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes (P < 0.0001, n = 10) to endothelial cells, an increase that was markedly attenuated when endothelial cells were treated with dexamethasone (IC50 < 1 nM, P < 0.0001, n = 6 or 7) during preincubation with LPS.@(((:tag . "NN") (:stem . "preincubation") (:form . "Preincubation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "endotoxin") (:form . 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5001603@unknown@formal@none@1@S@Moreover, the steroid receptor agonist cortisol (10 microM), but not its inactive metabolite tetrahydrocortisol (10 microM), diminished LPS-induced endothelial cell adhesiveness.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "tetrahydrocortisol") (:form . "tetrahydrocortisol")\n  (:end . 111) (:start . 93) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 135)\n  (:start . 125) (:id . 65))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 147)\n  (:start . 136) (:id . 66))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 159)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 164) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "adhesiveness") (:form . "adhesiveness") (:end . 177)\n  (:start . 165) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x180.6.1) (:span 65 68)))\n (:nscopes ((:id . :x180.6.1) (:span 65 123)))\n (:identifiers (:sid . :s180.6) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001604@unknown@formal@none@1@S@Further evidence that the action of dexamethasone was mediated through ligation of corticosteroid receptors [human glucocorticoid receptors (hGRs)] was provided by experiments utilizing the steroid antagonist RU-486.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 97) (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 129) (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 139)\n  (:start . 130) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "hgr") (:form . "hGRs") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 175)\n  (:start . 164) (:id . 67))\n ((:tag . "VBG") (:stem . "utilize") (:form . "utilizing") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "steroid") (:form . "steroid") (:end . 197)\n  (:start . 190) (:id . 70))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 208)\n  (:start . 198) (:id . 71))\n ((:tag . "NNP") (:stem . "RU-486") (:form . "RU-486") (:end . 215)\n  (:start . 209) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s180.7) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001605@unknown@formal@none@1@S@RU-486 (10 microM), which prevents translocation of ligated hGR to the nucleus by inhibiting dissociation of hGR from heat shock protein 90, completely aborted the effect of dexamethasone on adhesiveness of endothelial cells (P < 0.0005, n = 3).@(((:tag . "NNP") (:stem . "RU-486") (:form . "RU-486") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 25) (:start . 20)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 34)\n  (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 48) (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "ligate") (:form . "ligated") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "VBD") (:stem . "abort") (:form . "aborted") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 170)\n  (:start . 164) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 187) (:start . 174) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 190) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "adhesiveness") (:form . "adhesiveness") (:end . 203)\n  (:start . 191) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 218)\n  (:start . 207) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 224)\n  (:start . 219) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 226) (:start . 225)\n  (:id . 79))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 227) (:start . 226)\n  (:id . 80))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 229) (:start . 228)\n  (:id . 81))\n ((:tag . "CD") (:stem . "0.0005") (:form . "0.0005") (:end . 236)\n  (:start . 230) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 237) (:start . 236)\n  (:id . 83))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 239) (:start . 238)\n  (:id . 84))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 241) (:start . 240)\n  (:id . 85))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 243) (:start . 242)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 244) (:start . 243)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s180.8) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001606@unknown@formal@none@1@S@Treatment of endothelial cells with LPS (1 microgram/ml) stimulated transcription of ELAM-1, as shown by Northern blot analysis, and expression of membrane-associated ELAM-1 and ICAM-1, as shown by quantitative immunofluorescence (both P < 0.001, n = 9).@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "microgram/ml") (:form . "microgram/ml") (:end . 55)\n  (:start . 43) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "elam-1") (:form . "ELAM-1") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "membrane-associated")\n  (:form . "membrane-associated") (:end . 166) (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "elam-1") (:form . "ELAM-1") (:end . 173)\n  (:start . 167) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "quantitative") (:form . "quantitative") (:end . 210)\n  (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 229) (:start . 211) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 77))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 235) (:start . 231)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 237) (:start . 236)\n  (:id . 79))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 239) (:start . 238)\n  (:id . 80))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 245)\n  (:start . 240) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 246) (:start . 245)\n  (:id . 82))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 248) (:start . 247)\n  (:id . 83))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 250) (:start . 249)\n  (:id . 84))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 252) (:start . 251)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 253) (:start . 252)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s180.9) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001607@unknown@formal@none@1@S@Dexamethasone markedly inhibited LPS-stimulated accumulation of mRNA for ELAM-1 and expression of ELAM-1 and ICAM-1 (IC50 < 10 nM, both P < 0.001, n = 4-9);@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 32)\n  (:start . 23) (:id . 44))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 47) (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 60)\n  (:start . 48) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 68) (:start . 64)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "elam-1") (:form . "ELAM-1") (:end . 79)\n  (:start . 73) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ELAM-1") (:form . "ELAM-1") (:end . 104)\n  (:start . 98) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IC50") (:form . "IC50") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 150) (:start . 149)\n  (:id . 69))\n ((:tag . "CD") (:stem . "4-9") (:form . "4-9") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 156) (:start . 155)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s180.10) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001608@unknown@formal@none@1@S@inhibition of expression by dexamethasone was reversed by RU-486 (both P < 0.005, n = 4-6).@(((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RU-486") (:form . "RU-486") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "CD") (:stem . "0.005") (:form . "0.005") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "CD") (:stem . "4-6") (:form . "4-6") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s180.11) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001610@unknown@formal@none@1@S@In contrast, sodium salicylate (1 mM) inhibited neither adhesion nor expression of these adhesion molecules.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x180.13.1) (:span 48 55 65 68)))\n (:nscopes ((:id . :x180.13.1) (:span 48 107)))\n (:identifiers (:sid . :s180.13) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001611@unknown@formal@none@1@S@These studies suggest that antagonism by dexamethasone of endotoxin-induced inflammation is a specific instance of the general biological principle that the glucocorticoid receptor is a hormone-dependent regulator of transcription.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antagonism") (:form . "antagonism") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endotoxin-induced") (:form . "endotoxin-induced")\n  (:end . 75) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 88)\n  (:start . 76) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 137)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "principle") (:form . "principle") (:end . 147)\n  (:start . 138) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 171) (:start . 157) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 180)\n  (:start . 172) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 183) (:start . 181)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hormone-dependent") (:form . "hormone-dependent")\n  (:end . 203) (:start . 186) (:id . 67))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 213)\n  (:start . 204) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 230) (:start . 217) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x180.14.1) (:span 14 21)))\n (:hscopes ((:id . :x180.14.1) (:span 14 230)))\n (:identifiers (:sid . :s180.14) (:did . :|93066282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001612@unknown@formal@none@1@S@Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action.@(((:tag . "NNP") (:stem . "Membrane") (:form . "Membrane") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 73) (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s181.1) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001613@unknown@formal@none@1@S@Rapid nongenomic in vitro effects of aldosterone on intracellular electrolytes, cell volume, and Na(+)-H+ antiport have been found in human mononuclear leukocytes (HML).@(((:tag . "JJ") (:stem . "rapid") (:form . "Rapid") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nongenomic") (:form . "nongenomic") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "electrolyte") (:form . "electrolytes") (:end . 78)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "volume") (:form . "volume") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "Na(+)-H+") (:form . "Na(+)-H+") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "antiport") (:form . "antiport") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HML") (:form . "HML") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s181.2) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001614@unknown@formal@none@1@S@Binding of 125I-labeled aldosterone to plasma membranes of HML shares important features with these functional data.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "125i-labeled") (:form . "125I-labeled") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HML") (:form . "HML") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "share") (:form . "shares") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 115)\n  (:start . 111) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s181.3) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001615@unknown@formal@none@1@S@This includes a very low apparent dissociation constant (Kd) of 0.1 nM for both aldosterone and the effect on the Na(+)-H(+)-antiport, a high turnover rate, and the almost exclusive binding selectivity for aldosterone.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 91)\n  (:start . 80) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Na(+)-H(+)-antiport")\n  (:form . "Na(+)-H(+)-antiport") (:end . 133) (:start . 114) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 141) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 150)\n  (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 72))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 171)\n  (:start . 165) (:id . 73))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 181)\n  (:start . 172) (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 189)\n  (:start . 182) (:id . 75))\n ((:tag . "NN") (:stem . "selectivity") (:form . "selectivity") (:end . 201)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 205) (:start . 202)\n  (:id . 77))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 217)\n  (:start . 206) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s181.4) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001616@unknown@formal@none@1@S@Dexamethasone, RU 26988, corticosterone, ouabain, amiloride, and 18-hydroxyprogesterone were inactive as ligands.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "26988") (:form . "26988") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "corticosterone") (:form . "corticosterone")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ouabain") (:form . "ouabain") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "amiloride") (:form . "amiloride") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "18-hydroxyprogesterone")\n  (:form . "18-hydroxyprogesterone") (:end . 87) (:start . 65) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s181.5) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001617@unknown@formal@none@1@S@Deoxycorticosterone acetate had an intermediate activity with an apparent Kd of 100 nM.@(((:tag . "NNP") (:stem . "Deoxycorticosterone")\n  (:form . "Deoxycorticosterone") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 27)\n  (:start . 20) (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 47)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "kd") (:form . "Kd") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s181.6) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001618@unknown@formal@none@1@S@These findings are the first to demonstrate membrane binding of aldosterone being compatible with major aspects of its nongenomic effects.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nongenomic") (:form . "nongenomic") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s181.7) (:did . :|93072349|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001620@unknown@formal@none@1@S@Promiscuous transcriptional activity of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) was detected in transient expression assays using LTR-chloramphenicol acetyltransferase-encoding gene chimeras, and cells of diverse species and tissue type;@(((:tag . "JJ") (:stem . "promiscuous") (:form . "Promiscuous") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reticuloendotheliosis")\n  (:form . "reticuloendotheliosis") (:end . 65) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 71) (:start . 66)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "REV") (:form . "REV") (:end . 76) (:start . 73)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 98)\n  (:start . 92) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 154) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LTR-chloramphenicol")\n  (:form . "LTR-chloramphenicol") (:end . 174) (:start . 155) (:id . 65))\n ((:tag . "JJ") (:stem . "acetyltransferase-encoding")\n  (:form . "acetyltransferase-encoding") (:end . 201) (:start . 175)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 206) (:start . 202)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "chimera") (:form . "chimeras") (:end . 215)\n  (:start . 207) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 237)\n  (:start . 230) (:id . 73))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 245)\n  (:start . 238) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 249) (:start . 246)\n  (:id . 75))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 256)\n  (:start . 250) (:id . 76))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 261) (:start . 257)\n  (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 262) (:start . 261)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s182.2) (:did . :|93077034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001621@unknown@formal@none@1@S@levels of expression from two different REV LTRs correlate with reports of pathogenicity of the respective viruses in vivo.@(((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "REV") (:form . "REV") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pathogenicity") (:form . "pathogenicity")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s182.3) (:did . :|93077034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001622@unknown@formal@none@1@S@REVs do not encode a transactivator targeted to the viral LTR, and cells infected with Marek 's disease virus, a herpesvirus with an overlapping host range, do not express factors that preferentially enhance expression from REV or avian sarcoma/leukemia virus LTRs.@(((:tag . "NNS") (:stem . "rev") (:form . "REVs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 35) (:start . 21) (:id . 47))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Marek") (:form . "Marek") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 124)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 144)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 171)\n  (:start . 164) (:id . 73))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 179)\n  (:start . 172) (:id . 74))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 184) (:start . 180)\n  (:id . 75))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 199) (:start . 185) (:id . 76))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 207)\n  (:start . 200) (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 218)\n  (:start . 208) (:id . 78))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 223) (:start . 219)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "REV") (:form . "REV") (:end . 227) (:start . 224)\n  (:id . 80))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 230) (:start . 228)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "avian") (:form . "avian") (:end . 236)\n  (:start . 231) (:id . 82))\n ((:tag . "NN") (:stem . "sarcoma/leukemia") (:form . "sarcoma/leukemia")\n  (:end . 253) (:start . 237) (:id . 83))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 259)\n  (:start . 254) (:id . 84))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 264) (:start . 260)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x182.4.1) (:span 160 163)) ((:id . :x182.4.2) (:span 8 11)))\n (:nscopes ((:id . :x182.4.1) (:span 160 264))\n  ((:id . :x182.4.2) (:span 8 61)))\n (:identifiers (:sid . :s182.4) (:did . :|93077034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001623@unknown@formal@none@1@S@REV LTRs work efficiently in human lymphoid cells, and are viable alternatives to promoters commonly used for expression of cloned genes.@(((:tag . "NNP") (:stem . "REV") (:form . "REV") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "LTR") (:form . "LTRs") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "work") (:form . "work") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "alternative") (:form . "alternatives") (:end . 78)\n  (:start . 66) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x182.5.1) (:span 59 65)))\n (:hscopes ((:id . :x182.5.1) (:span 59 136)))\n (:identifiers (:sid . :s182.5) (:did . :|93077034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001624@unknown@formal@none@1@S@They may also prove useful in the identification of new, ubiquitous cellular transcription factors.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 48) (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x182.6.1) (:span 5 8)))\n (:hscopes ((:id . :x182.6.1) (:span 5 98)))\n (:identifiers (:sid . :s182.6) (:did . :|93077034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001625@unknown@formal@none@1@S@Natural variants of the HIV-1 long terminal repeat: analysis of promoters with duplicated DNA regulatory motifs.@(((:tag . "JJ") (:stem . "natural") (:form . "Natural") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "duplicated") (:form . "duplicated") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s183.1) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001626@unknown@formal@none@1@S@Sequence variation in the long terminal repeat (LTR) region of HIV-1 was analyzed in viral isolates of 17 infected individuals.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s183.2) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001627@unknown@formal@none@1@S@Two classes of LTR size variants were found.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s183.3) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001628@unknown@formal@none@1@S@One HIV-1 variant was detected containing an additional binding site for the transcription factor Sp1.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s183.4) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001630@unknown@formal@none@1@S@This variation was the result of a duplication of a short DNA sequence (CTG-motif).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "duplication") (:form . "duplication") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ctg-motif") (:form . "CTG-motif") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s183.6) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001631@unknown@formal@none@1@S@Cell culture experiments demonstrated that the natural variant with four Sp1 sites had a slightly higher promoter activity and viral replication rate than the isogenic control LTR with three Sp1 sites.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 144)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "isogenic") (:form . "isogenic") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 175)\n  (:start . 168) (:id . 67))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 190)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 200)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s183.7) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001632@unknown@formal@none@1@S@No positive effect of the duplicated CTG-motif could be detected.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "duplicate") (:form . "duplicated") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "ctg-motif") (:form . "CTG-motif") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x183.8.1) (:span 0 2)))\n (:nscopes ((:id . :x183.8.1) (:span 0 64)))\n (:identifiers (:sid . :s183.8) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001633@unknown@formal@none@1@S@In order to measure small differences in virus production more accurately, equal amounts of a size variant and the wild-type plasmid were cotransfected into T-cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "accurately") (:form . "accurately") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 151) (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s183.9) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001634@unknown@formal@none@1@S@The virus with four Sp1 sites did outgrow the three Sp1 virus in 35 days of culture and CTG-monomer virus outcompeted the CTG-dimer virus in 42 days.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "outgrow") (:form . "outgrow") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 83)\n  (:start . 76) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CTG-monomer") (:form . "CTG-monomer") (:end . 99)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "VBD") (:stem . "outcompete") (:form . "outcompeted") (:end . 117)\n  (:start . 106) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CTG-dimer") (:form . "CTG-dimer") (:end . 131)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s183.10) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001635@unknown@formal@none@1@S@Based on these results we estimate a 5-10% difference in virus production of the LTR variants when compared to that of wild-type.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "estimate") (:form . "estimate") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5-10") (:form . "5-10") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x183.11.1) (:span 26 34)))\n (:hscopes ((:id . :x183.11.1) (:span 26 128)))\n (:identifiers (:sid . :s183.11) (:did . :|93079901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001636@unknown@formal@none@1@S@SCL and related hemopoietic helix-loop-helix transcription factors.@(((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 44) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s184.1) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001637@unknown@formal@none@1@S@The helix-loop-helix (HLH) proteins are a family of transcription factors that include proteins critical to differentiation and development in species ranging from plants to mammals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hlh") (:form . "HLH") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 123) (:start . 108) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "plant") (:form . "plants") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s184.2) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001638@unknown@formal@none@1@S@Five members of this family (MYC, SCL, TAL-2, LYL-1 and E2A) are implicated in oncogenic events in human lymphoid tumors because of their consistent involvement in chromosomal translocations.@(((:tag . "CD") (:stem . "five") (:form . "Five") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MYC") (:form . "MYC") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TAL-2") (:form . "TAL-2") (:end . 44) (:start . 39)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LYL-1") (:form . "LYL-1") (:end . 51) (:start . 46)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 59) (:start . 56)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 75)\n  (:start . 65) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 88)\n  (:start . 79) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 95)\n  (:start . 89) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 113)\n  (:start . 105) (:id . 65))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 120)\n  (:start . 114) (:id . 66))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 128)\n  (:start . 121) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 137)\n  (:start . 132) (:id . 69))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 148)\n  (:start . 138) (:id . 70))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 160)\n  (:start . 149) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 175)\n  (:start . 164) (:id . 73))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 190) (:start . 176) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s184.3) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001640@unknown@formal@none@1@S@SCL is expressed in erythroid, megakaryocyte and mast cell populations (the same cell lineages as GATA-1, a zinc-finger transcription factor).@(((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 119)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s184.5) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001641@unknown@formal@none@1@S@In addition, both SCL and GATA-1 undergo coordinate modulation during chemically induced erythroid differentiation of mouse erythroleukemia cells and are down-modulated during myeloid differentiation of human K562 cells, thus implying a role for SCL in erythroid differentiation events.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "chemically") (:form . "chemically") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 114) (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 139) (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "down-modulate") (:form . "down-modulated")\n  (:end . 168) (:start . 154) (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 175)\n  (:start . 169) (:id . 64))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 183)\n  (:start . 176) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 199) (:start . 184) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 208)\n  (:start . 203) (:id . 68))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 213) (:start . 209)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 219)\n  (:start . 214) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 71))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 225) (:start . 221)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "imply") (:form . "implying") (:end . 234)\n  (:start . 226) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 236) (:start . 235)\n  (:id . 74))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 241) (:start . 237)\n  (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 245) (:start . 242)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 249) (:start . 246)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 262)\n  (:start . 253) (:id . 79))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 278) (:start . 263) (:id . 80))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 285)\n  (:start . 279) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x184.6.1) (:span 226 234)))\n (:hscopes ((:id . :x184.6.1) (:span 226 285)))\n (:identifiers (:sid . :s184.6) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001642@unknown@formal@none@1@S@However, in contrast to GATA-1, SCL is expressed in the developing brain.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 48)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 66)\n  (:start . 56) (:id . 54))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s184.7) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001643@unknown@formal@none@1@S@Studies of the function of SCL suggest  it is also important in proliferation and self-renewal events in erythroid cells.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "self-renewal") (:form . "self-renewal") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x184.8.1) (:span 31 38)))\n (:hscopes ((:id . :x184.8.1) (:span 31 120)))\n (:identifiers (:sid . :s184.8) (:did . :|93085167|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001644@unknown@formal@none@1@S@Transcription of the hypersensitive site HS2 enhancer in erythroid cells.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s185.1) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001645@unknown@formal@none@1@S@In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 43) (:start . 25) (:id . 48))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 58) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "JJ") (:stem . "beta-like") (:form . "beta-like") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 139)\n  (:start . 133) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 145)\n  (:start . 140) (:id . 61))\n ((:tag . "CD") (:stem . "10-50") (:form . "10-50") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 161)\n  (:start . 152) (:id . 63))\n ((:tag . "RB") (:stem . "away") (:form . "away") (:end . 166) (:start . 162)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s185.2) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001646@unknown@formal@none@1@S@The mechanism of HS2 enhancer function is not known.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 51)))@@@1@10@((:ncues ((:id . :x185.3.1) (:span 42 45)))\n (:nscopes ((:id . :x185.3.1) (:span 42 51)))\n (:identifiers (:sid . :s185.3) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001647@unknown@formal@none@1@S@The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "employ") (:form . "employs") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 78) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 132)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 148) (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 166) (:start . 149) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 171) (:start . 168)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 181)\n  (:start . 173) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s185.4) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001648@unknown@formal@none@1@S@In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 128)\n  (:start . 117) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 147)\n  (:start . 138) (:id . 66))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 158)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 68))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 183)\n  (:start . 175) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "elongate") (:form . "elongated") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 205)\n  (:start . 198) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "intervene") (:form . "intervening") (:end . 221)\n  (:start . 210) (:id . 76))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 225) (:start . 222)\n  (:id . 77))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 230) (:start . 226)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "cis-linked") (:form . "cis-linked") (:end . 245)\n  (:start . 235) (:id . 80))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 249) (:start . 246)\n  (:id . 81))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 254) (:start . 250)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x185.5.1) (:span 148 158)))\n (:hscopes ((:id . :x185.5.1) (:span 148 183)))\n (:identifiers (:sid . :s185.5) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001650@unknown@formal@none@1@S@Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene.@(((:tag . "VBG") (:stem . "split") (:form . "Splitting") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hs2") (:form . "HS2") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "ap1") (:form . "Ap1") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 119)\n  (:start . 108) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 160)\n  (:start . 152) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 180) (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 190)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cis-linked") (:form . "cis-linked") (:end . 208)\n  (:start . 198) (:id . 73))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 217) (:start . 213)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s185.7) (:did . :|93087498|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001651@unknown@formal@none@1@S@In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may ( i ) open up the chromatin structure of a gene domain and ( ii ) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . 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5001652@unknown@formal@none@1@S@Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells.@(((:tag . "NNP") (:stem . "Phorbol") (:form . "Phorbol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s186.1) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001653@unknown@formal@none@1@S@NF kappa B is a potent mediator of specific gene expression in human monocytes and has been shown to play a role in transcription of the HIV-1 genome in promonocytic leukemias.@(((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 22)\n  (:start . 16) (:id . 47))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 142)\n  (:start . 137) (:id . 68))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 149)\n  (:start . 143) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 165)\n  (:start . 153) (:id . 71))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 175)\n  (:start . 166) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s186.2) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001654@unknown@formal@none@1@S@There is little information available on the response of NF kappa B to cytokines in normal human monocytes.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s186.3) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001655@unknown@formal@none@1@S@We have used a 32P-labeled oligonucleotide derived from human immunodeficiency virus (HIV-1) long terminal repeat, which contains a tandem repeat of the NF kappa B binding sequence, as a probe in a gel retardation assay to study this transcription factor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "32p-labeled") (:form . "32P-labeled") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 42) (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 78) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 180)\n  (:start . 172) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 192)\n  (:start . 187) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 201) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 213)\n  (:start . 202) (:id . 79))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 219)\n  (:start . 214) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 222) (:start . 220)\n  (:id . 81))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 228)\n  (:start . 223) (:id . 82))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 233) (:start . 229)\n  (:id . 83))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 247) (:start . 234) (:id . 84))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 254)\n  (:start . 248) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s186.4) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001656@unknown@formal@none@1@S@Using this assay, we have detected NF kappa B in extracts of nuclei from normal human monocytes.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 57)\n  (:start . 49) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 67)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 79)\n  (:start . 73) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 95)\n  (:start . 86) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s186.5) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001657@unknown@formal@none@1@S@Treatment of normal monocytes with 12-0-tetradecanoyl phorbol-13-acetate (TPA) for 4-24 h caused the complete disappearance of NF kappa B from nuclear extracts of monocytes.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "12-0-tetradecanoyl") (:form . "12-0-tetradecanoyl")\n  (:end . 53) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "phorbol-13-acetate") (:form . "phorbol-13-acetate")\n  (:end . 72) (:start . 54) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4-24") (:form . "4-24") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "disappearance") (:form . "disappearance")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s186.6) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001658@unknown@formal@none@1@S@A similar result was obtained with the mature monocytic leukemia cell line THP-1.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s186.7) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001660@unknown@formal@none@1@S@The disappearance of NF kappa B from the nucleus was concentration dependent between 10 and 50 ng/ml of phorbol ester.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "disappearance") (:form . "disappearance")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s186.9) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001661@unknown@formal@none@1@S@In THP-1 cells, TPA also induced a new, faster-migrating NF kappa B species not induced in monocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "faster-migrating") (:form . "faster-migrating")\n  (:end . 56) (:start . 40) (:id . 52))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 75)\n  (:start . 68) (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 100)\n  (:start . 91) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x186.10.1) (:span 76 79)))\n (:nscopes ((:id . :x186.10.1) (:span 76 100)))\n (:identifiers (:sid . :s186.10) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001662@unknown@formal@none@1@S@Protein kinase C inhibitor staurosporine, but not cyclic nucleotide-dependent protein kinase inhibitor HA-1004, also dramatically reduced constitutive levels of nuclear NF kappa B.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "staurosporine") (:form . "staurosporine")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "nucleotide-dependent")\n  (:form . "nucleotide-dependent") (:end . 77) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "ha-1004") (:form . "HA-1004") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 129)\n  (:start . 117) (:id . 58))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 137)\n  (:start . 130) (:id . 59))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 150)\n  (:start . 138) (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 157)\n  (:start . 151) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 168)\n  (:start . 161) (:id . 63))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 177)\n  (:start . 172) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 179) (:start . 178)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x186.11.1) (:span 46 49)))\n (:nscopes ((:id . :x186.11.1) (:span 46 110)))\n (:identifiers (:sid . :s186.11) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001663@unknown@formal@none@1@S@Finally, TPA addition to monocytes infected with HIV-1 inhibited HIV-1 replication, as determined by reverse transcriptase assays, in a concentration-dependent manner.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "transcriptase") (:form . "transcriptase")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 159) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 166)\n  (:start . 160) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s186.12) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001664@unknown@formal@none@1@S@These results are in striking contrast to the increase in nuclear NF kappa B and HIV-1 replication induced by phorbol esters in promonocytic leukemia cells U937 and HL-60, and emphasize the importance of studying cytokine regulation of HIV-1 in normal monocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 140)\n  (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 170)\n  (:start . 165) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "emphasize") (:form . "emphasize") (:end . 185)\n  (:start . 176) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 200)\n  (:start . 190) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 212)\n  (:start . 204) (:id . 76))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 221)\n  (:start . 213) (:id . 77))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 232)\n  (:start . 222) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 241)\n  (:start . 236) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 244) (:start . 242)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 251)\n  (:start . 245) (:id . 82))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 261)\n  (:start . 252) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s186.13) (:did . :|93100507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5001666@unknown@formal@none@1@S@Mice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes.@(((:tag . "NNS") (:stem . "mouse") (:form . "Mice") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "JJ") (:stem . "fibroblastic") (:form . "fibroblastic") (:end . 90)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "JJ") (:stem . "b-inducible") (:form . "B-inducible") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s187.2) (:did . :|93101981|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001667@unknown@formal@none@1@S@In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "oligodeoxynucleotide")\n  (:form . "oligodeoxynucleotides") (:end . 79) (:start . 58) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ODN") (:form . "ODNs") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 103)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "culture-adapted") (:form . "culture-adapted")\n  (:end . 128) (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "tax-transformed") (:form . "Tax-transformed")\n  (:end . 144) (:start . 129) (:id . 60))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 156)\n  (:start . 145) (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 159) (:start . 157)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 164) (:start . 160)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 170) (:start . 168)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "htlv-i-transformed") (:form . "HTLV-I-transformed")\n  (:end . 189) (:start . 171) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 195)\n  (:start . 190) (:id . 67))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 206)\n  (:start . 196) (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 211) (:start . 207)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s187.3) (:did . :|93101981|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001668@unknown@formal@none@1@S@In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x187.4.1) (:span 52 54)))\n (:nscopes ((:id . :x187.4.1) (:span 52 85)))\n (:identifiers (:sid . :s187.4) (:did . :|93101981|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001670@unknown@formal@none@1@S@This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 131)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "htlv-i-associated") (:form . "HTLV-I-associated")\n  (:end . 162) (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 170)\n  (:start . 163) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x187.6.1) (:span 41 44)) ((:id . :x187.6.2) (:span 5 13)))\n (:hscopes ((:id . :x187.6.1) (:span 41 104))\n  ((:id . :x187.6.2) (:span 5 104)))\n (:identifiers (:sid . :s187.6) (:did . :|93101981|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001671@unknown@formal@none@1@S@Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation by dexamethasone, isoproterenol, or prostaglandin E2 either alone or in combination.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "antibody-induced") (:form . "antibody-induced")\n  (:end . 50) (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 57)\n  (:start . 51) (:id . 47))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 71) (:start . 58) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 88) (:start . 75) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 51))\n ((:tag . "NN") (:stem . "isoproterenol") (:form . "isoproterenol")\n  (:end . 103) (:start . 90) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 121) (:start . 108) (:id . 55))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 124) (:start . 122)\n  (:id . 56))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 131)\n  (:start . 125) (:id . 57))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 137)\n  (:start . 132) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 60))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 155)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s188.1) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001672@unknown@formal@none@1@S@1 . The purpose of these studies was to investigate the modulation of the proliferation of human T cells obtained from peripheral blood by dexamethasone (DEX), isoproterenol (ISO), and prostaglandin E2 (PGE2).@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 7) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 15)\n  (:start . 8) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 51)\n  (:start . 40) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 87) (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 152) (:start . 139) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DEX") (:form . "DEX") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . "NN") (:stem . "isoproterenol") (:form . "isoproterenol")\n  (:end . 173) (:start . 160) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "ISO") (:form . "ISO") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 76))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 198) (:start . 185) (:id . 77))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 201) (:start . 199)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 203) (:start . 202)\n  (:id . 79))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 207) (:start . 203)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s188.2) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001673@unknown@formal@none@1@S@The former two substances interact with T cells via the glucocorticoid and beta-adrenergic receptors respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "former") (:form . "former") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "substance") (:form . "substances") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 70) (:start . 56) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "beta-adrenergic") (:form . "beta-adrenergic")\n  (:end . 90) (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 113)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s188.3) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001674@unknown@formal@none@1@S@When occupied by their natural ligands, glucocorticosteroids and catecholamines, these receptors have a role in modulating T-cell function during stress.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 22)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroids") (:end . 60) (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "catecholamine") (:form . "catecholamines")\n  (:end . 79) (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 152)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s188.4) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001675@unknown@formal@none@1@S@During the inflammatory response increased levels of PGE2 bind to their receptors on T cells and thus alter responsiveness.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 71)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "alter") (:form . "alter") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 122) (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s188.5) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001676@unknown@formal@none@1@S@Proliferation of T cells was induced by immobilized anti-CD3 monoclonal antibody (mAb) in the presence or absence of an additional costimulatory signal delivered by anti-CD28 mAb.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "immobilize") (:form . "immobilized") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 130)\n  (:start . 120) (:id . 63))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 151)\n  (:start . 145) (:id . 65))\n ((:tag . "VBN") (:stem . "deliver") (:form . "delivered") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s188.6) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001677@unknown@formal@none@1@S@2 . Various physiologic concentrations of DEX, ISO, or PGE2 were added at the time of initiation of the cultures and subsequent proliferation of the unstimulated T cells was determined.@(((:tag . "LS") (:stem . "2") (:form . "2") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 11)\n  (:start . 4) (:id . 44))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DEX") (:form . "DEX") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ISO") (:form . "ISO") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 96)\n  (:start . 86) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 112)\n  (:start . 104) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 127)\n  (:start . 117) (:id . 65))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 141) (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 161)\n  (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 169)\n  (:start . 164) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 184)\n  (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s188.7) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001678@unknown@formal@none@1@S@The results demonstrate that physiologic concentrations of all three of these agents inhibit the anti-CD3 mAb-induced proliferation of T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 55) (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "JJ") (:stem . "mab-induced") (:form . "mAb-induced") (:end . 117)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 131) (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s188.8) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001680@unknown@formal@none@1@S@4 . Because concomitant elevations in the peripheral levels of these substances may occur, experiments were performed to determine the T-cell inhibitory effects of DEX together with either PGE2 or ISO.@(((:tag . "LS") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 11)\n  (:start . 4) (:id . 44))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "elevation") (:form . "elevations") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "substance") (:form . "substances") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 141)\n  (:start . 135) (:id . 63))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dex") (:form . "DEX") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 188)\n  (:start . 182) (:id . 70))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 196) (:start . 194)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "ISO") (:form . "ISO") (:end . 200) (:start . 197)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x188.10.1) (:span 80 83)))\n (:hscopes ((:id . :x188.10.1) (:span 80 89)))\n (:identifiers (:sid . :s188.10) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001681@unknown@formal@none@1@S@Synergistic suppression of T-cell proliferation was observed when various concentrations of DEX and PGE2, but not DEX and ISO, were added to cultures.@(((:tag . "JJ") (:stem . "synergistic") (:form . "Synergistic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 88) (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dex") (:form . "DEX") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DEX") (:form . "DEX") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "ISO") (:form . "ISO") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 137) (:start . 132)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x188.11.1) (:span 110 113)))\n (:nscopes ((:id . :x188.11.1) (:span 110 125)))\n (:identifiers (:sid . :s188.11) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001682@unknown@formal@none@1@S@This synergistic suppression could not be explained by an increase in cAMP accumulation in T cells stimulated with DEX and PGE2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 87)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dex") (:form . "DEX") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x188.12.1) (:span 29 38)))\n (:nscopes ((:id . :x188.12.1) (:span 0 127)))\n (:identifiers (:sid . :s188.12) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001683@unknown@formal@none@1@S@5 . Finally, the addition of anti-CD28 mAb to anti-CD3 mAb-stimulated T cells overcame much of the suppression of proliferation induced by PGE2 or ISO but less so than that induced by DEX.@(((:tag . "CD") (:stem . "5") (:form . "5") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "Finally") (:form . "Finally") (:end . 11)\n  (:start . 4) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 25)\n  (:start . 17) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "JJ") (:stem . "mab-stimulated") (:form . "mAb-stimulated")\n  (:end . 69) (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "overcome") (:form . "overcame") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "JJ") (:stem . "much") (:form . "much") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 127) (:start . 114) (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "ISO") (:form . "ISO") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 180)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 183) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "dex") (:form . "DEX") (:end . 187) (:start . 184)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s188.13) (:did . :|93105477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001684@unknown@formal@none@1@S@Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun.@(((:tag . "VBN") (:stem . "target") (:form . "Targeted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "v-fos") (:form . "v-Fos") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "phosphorylation-dependent")\n  (:form . "phosphorylation-dependent") (:end . 76) (:start . 51) (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x189.1.1) (:span 35 38)))\n (:nscopes ((:id . :x189.1.1) (:span 35 44)))\n (:identifiers (:sid . :s189.1) (:did . :|93110357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001685@unknown@formal@none@1@S@The proto-oncogene products c-Fos and c-Jun heterodimerize through their leucine zippers to form the AP-1 transcription factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "heterodimerize") (:form . "heterodimerize")\n  (:end . 58) (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 72)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "leucine") (:form . "leucine") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "zipper") (:form . "zippers") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s189.2) (:did . :|93110357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001686@unknown@formal@none@1@S@The transcriptional activity of the heterodimer is regulated by signal-dependent phosphorylation and dephosphorylation events.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "signal-dependent") (:form . "signal-dependent")\n  (:end . 80) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 96) (:start . 81) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dephosphorylation") (:form . "dephosphorylation")\n  (:end . 118) (:start . 101) (:id . 54))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 125)\n  (:start . 119) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s189.3) (:did . :|93110357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001687@unknown@formal@none@1@S@The stability of c-Fos was found to also be controlled by intracellular signal transduction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s189.4) (:did . :|93110357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001688@unknown@formal@none@1@S@In transient expression and in vitro degradation experiments, the stability of c-Fos was decreased when the protein was dimerized with phosphorylated c-Jun.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "dimerize") (:form . "dimerized") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 149) (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s189.5) (:did . :|93110357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5001691@unknown@formal@none@1@S@Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "child") (:form . "children") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s190.1) (:did . :|93112057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001692@unknown@formal@none@1@S@Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of growth hormone and prolactin genes.@(((:tag . "NNP") (:stem . "Pit-1") (:form . "Pit-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pituitary-specific") (:form . "pituitary-specific")\n  (:end . 29) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "transactivate") (:form . "transactivates")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "prolactin") (:form . "prolactin") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s190.2) (:did . :|93112057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001693@unknown@formal@none@1@S@In three unrelated Japanese children with combined pituitary hormone deficiency, we identified three point mutations in the Pit-1 gene, Pro24Leu, Arg143Gln, and Arg271Trp, located on the major transactivation region, POU-specific domain, and POU-homeodomain, respectively.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "japanese") (:form . "Japanese") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "child") (:form . "children") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Pro24Leu") (:form . "Pro24Leu") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Arg143Gln") (:form . "Arg143Gln") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Arg271Trp") (:form . "Arg271Trp") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 179)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 192)\n  (:start . 187) (:id . 73))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 208) (:start . 193) (:id . 74))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 215)\n  (:start . 209) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "pou-specific") (:form . "POU-specific") (:end . 229)\n  (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 236)\n  (:start . 230) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 237) (:start . 236)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 241) (:start . 238)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "POU-homeodomain") (:form . "POU-homeodomain")\n  (:end . 257) (:start . 242) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 258) (:start . 257)\n  (:id . 82))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 271)\n  (:start . 259) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s190.3) (:did . :|93112057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001694@unknown@formal@none@1@S@Calcitriol : a hematolymphopoietrope? [editorial]@(((:tag . "NNP") (:stem . "Calcitriol") (:form . "Calcitriol") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hematolymphopoietrope")\n  (:form . "hematolymphopoietrope") (:end . 36) (:start . 15) (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "editorial") (:form . "editorial") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 49) (:start . 48)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s191.1) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001695@unknown@formal@none@1@S@A MEDLINE search of the English-language literature was conducted using the indexing terms 'immunology, calcitriol and vitamin D' to identify studies indicating a role for calcitriol as a primary immunomodulator.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MEDLINE") (:form . "MEDLINE") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "english-language") (:form . "English-language")\n  (:end . 40) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "indexing") (:form . "indexing") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "'immunology") (:form . "'immunology") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 160)\n  (:start . 150) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 195)\n  (:start . 188) (:id . 72))\n ((:tag . "NN") (:stem . "immunomodulator") (:form . "immunomodulator")\n  (:end . 211) (:start . 196) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x191.2.1) (:span 150 160)))\n (:hscopes ((:id . :x191.2.1) (:span 150 211)))\n (:identifiers (:sid . :s191.2) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001696@unknown@formal@none@1@S@Sixty-six papers published between January 1956 and June 1991 were identified.@(((:tag . "CD") (:stem . "sixty-six") (:form . "Sixty-six") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "paper") (:form . "papers") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "NNP") (:stem . "January") (:form . "January") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "CD") (:stem . "1956") (:form . "1956") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s191.3) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001697@unknown@formal@none@1@S@Forty-five of these reports are cited in this review.@(((:tag . "CD") (:stem . "forty-five") (:form . "Forty-five") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "cite") (:form . "cited") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s191.4) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001698@unknown@formal@none@1@S@The data strongly suggest an endocrine, autocrine and/or paracrine role for calcitriol in immune regulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "endocrine") (:form . "endocrine") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "paracrine") (:form . "paracrine") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x191.5.1) (:span 50 56)) ((:id . :x191.5.2) (:span 18 25)))\n (:hscopes ((:id . :x191.5.1) (:span 29 66))\n  ((:id . :x191.5.2) (:span 18 107)))\n (:identifiers (:sid . :s191.5) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001700@unknown@formal@none@1@S@This paper provides a brief review of immune properties currently attributed to calcitriol.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "brief") (:form . "brief") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s191.7) (:did . :|93113611|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001701@unknown@formal@none@1@S@Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 77) (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VB") (:stem . "raise") (:form . "raise") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s192.1) (:did . :|93114357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001702@unknown@formal@none@1@S@We have earlier found that in Jurkat cells activation of protein kinase C (PKC) enhances the cyclic adenosine monophosphate (cAMP) accumulation induced by adenosine receptor stimulation or activation of Gs.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "monophosphate") (:form . "monophosphate")\n  (:end . 123) (:start . 110) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 143)\n  (:start . 131) (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 185)\n  (:start . 174) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 199)\n  (:start . 189) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Gs") (:form . "Gs") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s192.2) (:did . :|93114357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001703@unknown@formal@none@1@S@Here we have therefore examined the effect of the phorbol ester PMA (phorbol 12-myristate 13-acetate) which stimulates PKC and a combination of the adenosine receptor agonist NECA (5'-(N-ethyl)-carboxamido adenosine) and forskolin to raise cAMP, on the levels of c-Fos and Jun and on the binding and transcriptional activity of the transcription factor, activator protein-1 (AP-1).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . 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")") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 140)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . 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"raise") (:end . 239)\n  (:start . 234) (:id . 78))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 244) (:start . 240)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 80))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 248) (:start . 246)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 252) (:start . 249)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 259)\n  (:start . 253) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 262) (:start . 260)\n  (:id . 84))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 268)\n  (:start . 263) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 272) (:start . 269)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 276) (:start . 273)\n  (:id . 87))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 280) (:start . 277)\n  (:id . 88))\n ((:tag . 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5001704@unknown@formal@none@1@S@PMA treatment caused a concentration- and time-dependent increase in both c-Fos and Jun immunoreactivity in contrast to cAMP elevation that had only a slight effect.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "concentration-") (:form . "concentration-")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 56) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "jun") (:form . "Jun") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunoreactivity") (:form . "immunoreactivity")\n  (:end . 104) (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 157)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s192.4) (:did . :|93114357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001705@unknown@formal@none@1@S@Both PMA and the combination of NECA and forskolin acted together either to increase (c-Fos) or decrease (Jun) protein levels as well as increasing AP-1 binding, as judged by gel-shift assay, and AP-1 transcriptional activity.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NECA") (:form . "NECA") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "forskolin") (:form . "forskolin") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "act") (:form . "acted") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 118)\n  (:start . 111) (:id . 64))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 125)\n  (:start . 119) (:id . 65))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 147)\n  (:start . 137) (:id . 69))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 152) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 160)\n  (:start . 153) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 171)\n  (:start . 165) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 184)\n  (:start . 175) (:id . 76))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 190)\n  (:start . 185) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 200) (:start . 196)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 216) (:start . 201) (:id . 81))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 225)\n  (:start . 217) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s192.5) (:did . :|93114357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001706@unknown@formal@none@1@S@Furthermore there was a clear-cut synergy between the PKC stimulator and the cAMP elevating agents.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clear-cut") (:form . "clear-cut") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulator") (:form . "stimulator") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "elevate") (:form . "elevating") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s192.6) (:did . :|93114357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001707@unknown@formal@none@1@S@The results demonstrate that the simultaneous activation of PKC and elevation of cAMP leads to an enhanced AP-1 transcriptional activity in a T-leukemia cell line, suggesting that the previously observed interaction between the parallel signal transduction pathways may have functional consequences at the level of gene transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . 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5001708@unknown@formal@none@1@S@The use of interferon-gamma-treated U937 cells in chemiluminescence assays to detect red cell, platelet and granulocyte antibodies of potential clinical significance.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "interferon-gamma-treated")\n  (:form . "interferon-gamma-treated") (:end . 35) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chemiluminescence") (:form . "chemiluminescence")\n  (:end . 67) (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 84)\n  (:start . 78) (:id . 52))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 152)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 165)\n  (:start . 153) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s193.1) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001710@unknown@formal@none@1@S@A clone of U937 cells was selected which expressed Fc receptor I (Fc gamma RI) and which, after incubation with IFN-gamma for 72 h, was capable of generating high levels of lucigenin-enhanced CL.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 95) (:start . 90)\n  (:id . 62))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 106)\n  (:start . 96) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 121)\n  (:start . 112) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 128) (:start . 126)\n  (:id . 67))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 130) (:start . 129)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 135) (:start . 132)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 143)\n  (:start . 136) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "generate") (:form . "generating") (:end . 157)\n  (:start . 147) (:id . 73))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 162) (:start . 158)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 169)\n  (:start . 163) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "lucigenin-enhanced") (:form . "lucigenin-enhanced")\n  (:end . 191) (:start . 173) (:id . 77))\n ((:tag . "NNP") (:stem . "CL") (:form . "CL") (:end . 194) (:start . 192)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s193.3) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001711@unknown@formal@none@1@S@The CL responses of IFN-U937 cells and peripheral blood human monocytes to sensitized red cells, platelets or granulocytes were then compared.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CL") (:form . "CL") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ifn-u937") (:form . "IFN-U937") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "sensitize") (:form . "sensitized") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s193.4) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001712@unknown@formal@none@1@S@Assays using monocytes or IFN-U937 cells were of comparable sensitivity for detection of antibodies against all three types of target cell.@(((:tag . "NNS") (:stem . "assay") (:form . "Assays") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ifn-u937") (:form . "IFN-U937") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s193.5) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001713@unknown@formal@none@1@S@In addition, the use of IFN-U937 cells reduced interassay variation and simplified assay performance.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ifn-u937") (:form . "IFN-U937") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "interassay") (:form . "interassay") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "simplify") (:form . "simplified") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s193.6) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001714@unknown@formal@none@1@S@The potential clinical usefulness of these CL assays was suggested by the ability of both monocytes and IFN-U937 cells to respond to red cells, platelets or granulocytes sensitized with sera from pregnant women whose babies had either haemolytic disease of the newborn (HDN), alloimmune thrombocytopenia or alloimmune neutropenia respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "usefulness") (:form . "usefulness") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CL") (:form . 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5001715@unknown@formal@none@1@S@In addition, monocytes and IFN-U937 cells both responded to red cells sensitized with antibodies against a variety of specificities of assumed ( although not documented) clinical significance for blood transfusion recipients.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ifn-u937") (:form . "IFN-U937") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "sensitize") (:form . "sensitized") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "specificity") (:form . "specificities")\n  (:end . 131) (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 191)\n  (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 201)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "transfusion") (:form . "transfusion") (:end . 213)\n  (:start . 202) (:id . 73))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 224)\n  (:start . 214) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x193.8.2) (:span 135 142)))\n (:ncues ((:id . :x193.8.1) (:span 154 157)))\n (:hscopes ((:id . :x193.8.2) (:span 135 224)))\n (:nscopes ((:id . :x193.8.1) (:span 154 168)))\n (:identifiers (:sid . :s193.8) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001716@unknown@formal@none@1@S@In contrast, monocytes and IFN-U937 cells responded only weakly to red cells sensitized with either anti-D in sera from mothers of babies unaffected by HDN, or with antisera containing high titre antibodies with specificities not normally associated with significantly reduced red cell survival.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ifn-u937") (:form . "IFN-U937") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . 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(:end . 295) (:start . 294)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x193.9.1) (:span 226 229)))\n (:nscopes ((:id . :x193.9.1) (:span 226 294)))\n (:identifiers (:sid . :s193.9) (:did . :|93121695|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001717@unknown@formal@none@1@S@Involvement of Alu sequences in the cell-specific regulation of transcription of the gamma chain of Fc and T cell receptors.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Alu") (:form . "Alu") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s194.1) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001718@unknown@formal@none@1@S@The Fc epsilon RI-gamma chains are expressed in a variety of hematopoietic cells where they play a critical role in signal transduction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NNP") (:stem . "RI-gamma") (:form . "RI-gamma") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 74) (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 135)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s194.2) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001720@unknown@formal@none@1@S@Here we have investigated the transcriptional regulation of the gamma chain gene by analyzing the 2.5-kilobase sequence upstream of the transcription start site.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 45) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "analyze") (:form . "analyzing") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "2.5-kilobase") (:form . "2.5-kilobase") (:end . 110)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 155)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s194.4) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001721@unknown@formal@none@1@S@This sequence contains a promoter specific to cells of hematopoietic lineage.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s194.5) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001722@unknown@formal@none@1@S@However, the tissue specificity of this promoter is only partial because it is active in all of the hematopoietic cells tested here, regardless of whether they constitutively express Fc epsilon RI-gamma chain transcripts.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 113) (:start . 100) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 143)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 174) (:start . 160) (:id . 70))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 193)\n  (:start . 186) (:id . 73))\n ((:tag . "NNP") (:stem . "RI-gamma") (:form . "RI-gamma") (:end . 202)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 208)\n  (:start . 203) (:id . 75))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 220)\n  (:start . 209) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x194.6.1) (:span 147 154)))\n (:hscopes ((:id . :x194.6.1) (:span 147 220)))\n (:identifiers (:sid . :s194.6) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001723@unknown@formal@none@1@S@We have identified two adjacent cis-acting regulatory elements, both of which are part of an Alu repeat.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Alu") (:form . "Alu") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s194.7) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001724@unknown@formal@none@1@S@The first (-445/-366) is a positive element active in both basophils and T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "-445/-366") (:form . "-445/-366") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 35)\n  (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s194.8) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001725@unknown@formal@none@1@S@The second (-365/-264) binds to nuclear factors, which appear to be different in basophils and T cells, and acts as a negative element in basophils and as a positive one in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "-365/-264") (:form . "-365/-264") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 77)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 112) (:start . 108)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 126)\n  (:start . 118) (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 134)\n  (:start . 127) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 147)\n  (:start . 138) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 154) (:start . 152)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 165)\n  (:start . 157) (:id . 74))\n ((:tag . "NN") (:stem . "one") (:form . "one") (:end . 169) (:start . 166)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 180)\n  (:start . 175) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x194.9.1) (:span 55 61)))\n (:hscopes ((:id . :x194.9.1) (:span 49 102)))\n (:identifiers (:sid . :s194.9) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001726@unknown@formal@none@1@S@Thus, this Alu repeat (90% identical to Alu consensus sequences) has evolved to become both a positive and negative regulator.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Alu") (:form . "Alu") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 21)\n  (:start . 15) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 26) (:start . 25)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 36)\n  (:start . 27) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Alu") (:form . "Alu") (:end . 43) (:start . 40)\n  (:id . 52))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 53)\n  (:start . 44) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 63)\n  (:start . 54) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 76)\n  (:start . 69) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 86)\n  (:start . 80) (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 102)\n  (:start . 94) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 115)\n  (:start . 107) (:id . 64))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 125)\n  (:start . 116) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s194.10) (:did . :|93123257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001727@unknown@formal@none@1@S@Human immunodeficiency viruses containing heterologous enhancer/promoters are replication competent and exhibit different lymphocyte tropisms.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 54)\n  (:start . 42) (:id . 46))\n ((:tag . "NNS") (:stem . "enhancer/promoter") (:form . "enhancer/promoters")\n  (:end . 73) (:start . 55) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 89)\n  (:start . 78) (:id . 49))\n ((:tag . "JJ") (:stem . "competent") (:form . "competent") (:end . 99)\n  (:start . 90) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 111)\n  (:start . 104) (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 121)\n  (:start . 112) (:id . 53))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 132)\n  (:start . 122) (:id . 54))\n ((:tag . "NNS") (:stem . "tropism") (:form . "tropisms") (:end . 141)\n  (:start . 133) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s195.1) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001728@unknown@formal@none@1@S@The human immunodeficiency virus (HIV) type 1 long terminal repeat (LTR) contains binding sites for nuclear factor kappa B (NF-kappa B) and the constitutively expressed transcription factor Sp1, both of which are highly conserved in HIV and simian immunodeficiency virus isolates.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 26) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 132)\n  (:start . 124) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 70))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 158) (:start . 144) (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 168)\n  (:start . 159) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 182) (:start . 169) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 189)\n  (:start . 183) (:id . 74))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 193) (:start . 190)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 76))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 208)\n  (:start . 203) (:id . 79))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 212) (:start . 209)\n  (:id . 80))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 219)\n  (:start . 213) (:id . 81))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 229)\n  (:start . 220) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 236) (:start . 233)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 247)\n  (:start . 241) (:id . 86))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 264) (:start . 248) (:id . 87))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 270)\n  (:start . 265) (:id . 88))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 279)\n  (:start . 271) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s195.2) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001730@unknown@formal@none@1@S@The effects of these substitutions on viral replication in transfected HeLa cells and on HIV infection of human peripheral blood lymphocytes or continuous T-leukemia cell lines were evaluated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . "NNP") (:stem . "T-leukemia") (:form . "T-leukemia") (:end . 165)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 191)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s195.4) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001731@unknown@formal@none@1@S@HIVs in which the NF- kappa B/Sp1 enhancer plus the downstream TATA element were replaced with heterologous enhancer/promoters were also constructed.@(((:tag . "NNS") (:stem . "hiv") (:form . "HIVs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "nf-") (:form . "NF-") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b/sp1") (:form . "B/Sp1") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "enhancer/promoter") (:form . "enhancer/promoters")\n  (:end . 126) (:start . 108) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 148)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s195.5) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001732@unknown@formal@none@1@S@Viruses containing the human cytomegalovirus immediate-early enhancer exhibited infectious kinetics similar to that of wild-type HIV in activated human peripheral blood lymphocytes and AA2 cells but replicated less efficiently in H9 and CEM cells.@(((:tag . "NNS") (:stem . "virus") (:form . "Viruses") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 44) (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 60) (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 69)\n  (:start . 61) (:id . 48))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 79)\n  (:start . 70) (:id . 49))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 90)\n  (:start . 80) (:id . 50))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 99)\n  (:start . 91) (:id . 51))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 107)\n  (:start . 100) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 128)\n  (:start . 119) (:id . 56))\n ((:tag . "NN") (:stem . "hiv") (:form . "HIV") (:end . 132) (:start . 129)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 145)\n  (:start . 136) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 60))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 162)\n  (:start . 152) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 168)\n  (:start . 163) (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 180)\n  (:start . 169) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 64))\n ((:tag . "NN") (:stem . "aa2") (:form . "AA2") (:end . 188) (:start . 185)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 198) (:start . 195)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "replicate") (:form . "replicated") (:end . 209)\n  (:start . 199) (:id . 68))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 214) (:start . 210)\n  (:id . 69))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 226)\n  (:start . 215) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 232) (:start . 230)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 240) (:start . 237)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 246)\n  (:start . 241) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s195.6) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001733@unknown@formal@none@1@S@These studies indicate that heterologous enhancer elements are capable of restoring Tat responsiveness to the HIV LTR in the context of directing reporter gene expression as well as in the production of infectious progeny virions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "restore") (:form . "restoring") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "tat") (:form . "Tat") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 102) (:start . 88) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 199)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 213)\n  (:start . 203) (:id . 74))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 221)\n  (:start . 214) (:id . 75))\n ((:tag . "NNS") (:stem . "virion") (:form . "virions") (:end . 229)\n  (:start . 222) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x195.7.1) (:span 14 27)))\n (:hscopes ((:id . :x195.7.1) (:span 14 229)))\n (:identifiers (:sid . :s195.7) (:did . :|93124567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001734@unknown@formal@none@1@S@Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B- lymphocyte precursors [ published erratum appears in Proc Natl Acad Sci U S A 1993 Apr 15;90 ( 8 ) : 3775 ]@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mandatory") (:form . "mandatory") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "radiation-induced") (:form . "radiation-induced")\n  (:end . 74) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "b-") (:form . "B-") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 173)\n  (:start . 164) (:id . 65))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 181)\n  (:start . 174) (:id . 66))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 189)\n  (:start . 182) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Proc") (:form . "Proc") (:end . 197) (:start . 193)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Natl") (:form . "Natl") (:end . 202) (:start . 198)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Acad") (:form . "Acad") (:end . 207) (:start . 203)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Sci") (:form . "Sci") (:end . 211) (:start . 208)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 213) (:start . 212)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 215) (:start . 214)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 217) (:start . 216)\n  (:id . 75))\n ((:tag . "CD") (:stem . "1993") (:form . "1993") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Apr") (:form . "Apr") (:end . 226) (:start . 223)\n  (:id . 77))\n ((:tag . "CD") (:stem . "15;90") (:form . "15;90") (:end . 232)\n  (:start . 227) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 234) (:start . 233)\n  (:id . 79))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 236) (:start . 235)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 238) (:start . 237)\n  (:id . 81))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 240) (:start . 239)\n  (:id . 82))\n ((:tag . "CD") (:stem . "3775") (:form . "3775") (:end . 245) (:start . 241)\n  (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 247) (:start . 246)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s196.1) (:did . :|93126354|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001735@unknown@formal@none@1@S@Ionizing radiation triggers a signal in human B-lymphocyte precursors that is intimately linked to an active protein-tyrosine kinase regulatory pathway.@(((:tag . "VBG") (:stem . "ionize") (:form . "Ionizing") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "RB") (:stem . "intimately") (:form . "intimately") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 95) (:start . 89)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 125) (:start . 109) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 151)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s196.2) (:did . :|93126354|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001736@unknown@formal@none@1@S@We show that in B-lymphocyte precursors, irradiation with gamma-rays leads to ( i ) stimulation of phosphatidylinositol turnover; ( ii ) downstream activation by covalent modification of multiple serine-specific protein kinases, including protein kinase C; and ( iii ) activation of nuclear factor kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte") (:end . 28)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . 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5001737@unknown@formal@none@1@S@All of the radiation-induced signals were effectively prevented by the protein-tyrosine kinase inhibitors genistein and herbimycin A.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "radiation-induced") (:form . "radiation-induced")\n  (:end . 28) (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 87) (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 115)\n  (:start . 106) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 130)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 132) (:start . 131)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s196.4) (:did . :|93126354|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001738@unknown@formal@none@1@S@Thus, tyrosine phosphorylation is an important and perhaps mandatory proximal step in the activation of the protein kinase C signaling cascade in human B-lymphocyte precursors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 30) (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "mandatory") (:form . "mandatory") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 164) (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x196.5.1) (:span 51 58)))\n (:hscopes ((:id . :x196.5.1) (:span 51 68)))\n (:identifiers (:sid . :s196.5) (:did . :|93126354|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001740@unknown@formal@none@1@S@Photoaffinity labeling of plasma membrane receptors for aldosterone from human mononuclear leukocytes.@(((:tag . "NNP") (:stem . "Photoaffinity") (:form . "Photoaffinity")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "labeling") (:form . "labeling") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 67)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 90)\n  (:start . 79) (:id . 52))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s197.1) (:did . :|93129206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001741@unknown@formal@none@1@S@Non-genomic effects of aldosterone on the sodium-proton-antiport have been shown in human mononuclear leukocytes which could be related to a new aldosterone membrane receptor.@(((:tag . "JJ") (:stem . "non-genomic") (:form . "Non-genomic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sodium-proton-antiport")\n  (:form . "sodium-proton-antiport") (:end . 64) (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 69) (:start . 65)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 124)\n  (:start . 119) (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 156)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x197.2.1) (:span 119 124)))\n (:hscopes ((:id . :x197.2.1) (:span 113 174)))\n (:identifiers (:sid . :s197.2) (:did . :|93129206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001742@unknown@formal@none@1@S@In the present paper plasma membranes from human mononuclear leukocytes were covalently photolabeled with a [125I]-aldosterone derivative.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "RB") (:stem . "covalently") (:form . "covalently") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "VBN") (:stem . "photolabele") (:form . "photolabeled") (:end . 100)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "125I]-aldosterone") (:form . "125I]-aldosterone")\n  (:end . 126) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 137)\n  (:start . 127) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s197.3) (:did . :|93129206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001743@unknown@formal@none@1@S@Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed significant aldosterone binding at a molecular weight of approximately 50000 Dalton which was absent with 1 microM cold aldosterone, but not cortisol in the binding media.@(((:tag . "NN") (:stem . "sodium") (:form . "Sodium") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dodecyl") (:form . "dodecyl") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "sulfate-polyacrylamide")\n  (:form . "sulfate-polyacrylamide") (:end . 37) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 41) (:start . 38)\n  (:id . 45))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 57) (:start . 42) (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 64) (:start . 58)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 76)\n  (:start . 65) (:id . 48))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 88)\n  (:start . 77) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 99) (:start . 97)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 111)\n  (:start . 102) (:id . 53))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 118)\n  (:start . 112) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 55))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 135) (:start . 122) (:id . 56))\n ((:tag . "CD") (:stem . "50000") (:form . "50000") (:end . 141)\n  (:start . 136) (:id . 57))\n ((:tag . "NNP") (:stem . "Dalton") (:form . "Dalton") (:end . 148)\n  (:start . 142) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 154)\n  (:start . 149) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 158) (:start . 155)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 165)\n  (:start . 159) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 172) (:start . 171)\n  (:id . 63))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 179)\n  (:start . 173) (:id . 64))\n ((:tag . "JJ") (:stem . "cold") (:form . "cold") (:end . 184) (:start . 180)\n  (:id . 65))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 196)\n  (:start . 185) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 201) (:start . 198)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 205) (:start . 202)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 214)\n  (:start . 206) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 229)\n  (:start . 222) (:id . 73))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 235)\n  (:start . 230) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x197.4.1) (:span 202 205)))\n (:nscopes ((:id . :x197.4.1) (:span 202 214)))\n (:identifiers (:sid . :s197.4) (:did . :|93129206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001744@unknown@formal@none@1@S@The presence of the sulfhydryl agent dithiothreitol did not affect results suggesting the absence of disulfide bridges in the steroid binding domain of the receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sulfhydryl") (:form . "sulfhydryl") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dithiothreitol") (:form . "dithiothreitol")\n  (:end . 51) (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NNS") (:stem . "bridge") (:form . "bridges") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x197.5.2) (:span 75 85)))\n (:ncues ((:id . :x197.5.1) (:span 90 97)) ((:id . :x197.5.3) (:span 56 59)))\n (:hscopes ((:id . :x197.5.2) (:span 75 164)))\n (:nscopes ((:id . :x197.5.1) (:span 90 164))\n  ((:id . :x197.5.3) (:span 56 74)))\n (:identifiers (:sid . :s197.5) (:did . :|93129206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001745@unknown@formal@none@1@S@These data are the first to define the molecular weight of the membrane receptor for aldosterone.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 96)\n  (:start . 85) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s197.6) (:did . :|93129206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001746@unknown@formal@none@1@S@Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells.@(((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "Alpha-lipoic") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s198.1) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001747@unknown@formal@none@1@S@Acquired immunodeficiency syndrome (AIDS) results from infection with a human immunodeficiency virus (HIV).@(((:tag . "VBN") (:stem . "acquire") (:form . "Acquired") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 25) (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 94) (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s198.2) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001748@unknown@formal@none@1@S@The long terminal repeat (LTR) region of HIV proviral DNA contains binding sites for nuclear factor kappa B (NF-kappa B), and this transcriptional activator appears to regulate HIV activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 53)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 130) (:start . 126)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 146) (:start . 131) (:id . 69))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 156)\n  (:start . 147) (:id . 70))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 164)\n  (:start . 157) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 176)\n  (:start . 168) (:id . 73))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 180) (:start . 177)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 191)\n  (:start . 181) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x198.3.1) (:span 157 164)))\n (:hscopes ((:id . :x198.3.1) (:span 126 191)))\n (:identifiers (:sid . :s198.3) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001750@unknown@formal@none@1@S@The present study was based on reports that antioxidants which eliminate ROS should block the activation of NF-kappa B and subsequently HIV transcription, and thus antioxidants can be used as therapeutic agents for AIDS.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 56)\n  (:start . 44) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "eliminate") (:form . "eliminate") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "ros") (:form . "ROS") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 135)\n  (:start . 123) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 176)\n  (:start . 164) (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 203)\n  (:start . 192) (:id . 73))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 210)\n  (:start . 204) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 214) (:start . 211)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 219) (:start . 215)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x198.5.1) (:span 177 180))\n  ((:id . :x198.5.2) (:span 77 83)))\n (:hscopes ((:id . :x198.5.1) (:span 164 219))\n  ((:id . :x198.5.2) (:span 77 153)))\n (:identifiers (:sid . :s198.5) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001751@unknown@formal@none@1@S@Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml).@(((:tag . "NNP") (:stem . "Incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "x") (:form . 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5001752@unknown@formal@none@1@S@The inhibitory action of alpha-lipoic acid was found to be very potent as only 4 mM was needed for a complete inhibition, whereas 20 mM was required for N-acetylcysteine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "alpha-lipoic") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 94) (:start . 88)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 120)\n  (:start . 110) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 135) (:start . 133)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 139) (:start . 136)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 148)\n  (:start . 140) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 169) (:start . 153) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s198.7) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001753@unknown@formal@none@1@S@These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "alpha-lipoic") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "therapeutic") (:form . "therapeutics") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x198.8.1) (:span 46 49)) ((:id . :x198.8.2) (:span 14 27)))\n (:hscopes ((:id . :x198.8.1) (:span 46 83))\n  ((:id . :x198.8.2) (:span 14 83)))\n (:identifiers (:sid . :s198.8) (:did . :|93129248|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001754@unknown@formal@none@1@S@A human putative lymphocyte G0/G1 switch gene homologous to a rodent gene encoding a zinc-binding potential transcription factor.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rodent") (:form . "rodent") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "zinc-binding") (:form . "zinc-binding") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x199.1.1) (:span 8 16)))\n (:hscopes ((:id . :x199.1.1) (:span 8 45)))\n (:identifiers (:sid . :s199.1) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001755@unknown@formal@none@1@S@G0S24 is a member of a set of genes (putative G0/G1 switch regulatory genes) that are expressed transiently within 1-2 hr of the addition of lectin or cycloheximide to human blood mononuclear cells.@(((:tag . "NNP") (:stem . "G0S24") (:form . "G0S24") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 35) (:start . 30)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 45)\n  (:start . 37) (:id . 52))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 51) (:start . 46)\n  (:id . 53))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 58)\n  (:start . 52) (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 69)\n  (:start . 59) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 95)\n  (:start . 86) (:id . 60))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 107)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "CD") (:stem . "1-2") (:form . "1-2") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 147)\n  (:start . 141) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 164) (:start . 151) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 173)\n  (:start . 168) (:id . 73))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 191)\n  (:start . 180) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x199.2.1) (:span 37 45)))\n (:hscopes ((:id . :x199.2.1) (:span 37 75)))\n (:identifiers (:sid . :s199.2) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001756@unknown@formal@none@1@S@Comparison of a full-length cDNA sequence with the corresponding genomic sequence reveals an open reading frame of 326 amino acids, distributed across two exons.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "CD") (:stem . "326") (:form . "326") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 150)\n  (:start . 144) (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s199.3) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001757@unknown@formal@none@1@S@Potential phosphorylation sites include the sequence PSPTSPT, which resembles an RNA polymerase II repeat reported to be a target of the cell cycle control kinase cdc2.@(((:tag . "JJ") (:stem . "potential") (:form . "Potential") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 25) (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 31) (:start . 26)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "psptspt") (:form . "PSPTSPT") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "resemble") (:form . "resembles") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 162)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "cdc2") (:form . "cdc2") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s199.4) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001758@unknown@formal@none@1@S@Comparison of the derived protein sequence with those of rodent homologs allows classification into three groups.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rodent") (:form . "rodent") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "classification") (:form . "classification")\n  (:end . 94) (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s199.5) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001760@unknown@formal@none@1@S@Members of this group have three tetraproline repeats.@(((:tag . "NNS") (:stem . "member") (:form . "Members") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tetraproline") (:form . "tetraproline") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s199.7) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001761@unknown@formal@none@1@S@Groups 1 and 2 have a serine-rich region and an " arginine element " (RRLPIF) at the carboxyl terminus.@(((:tag . "NNS") (:stem . "group") (:form . "Groups") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "serine-rich") (:form . "serine-rich") (:end . 33)\n  (:start . 22) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "arginine") (:form . "arginine") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RRLPIF") (:form . "RRLPIF") (:end . 76)\n  (:start . 70) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 60))\n ((:tag . "NN") (:stem . "carboxyl") (:form . "carboxyl") (:end . 93)\n  (:start . 85) (:id . 61))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 102)\n  (:start . 94) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s199.8) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001762@unknown@formal@none@1@S@All groups contain cysteine- and histidine-rich putative zinc finger domains and a serine-phenylalanine " SFS " domain similar to part of the large subunit of eukaryotic RNA polymerase II.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "cysteine-") (:form . "cysteine-") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "histidine-rich") (:form . "histidine-rich")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "serine-phenylalanine")\n  (:form . "serine-phenylalanine") (:end . 103) (:start . 83) (:id . 54))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sfs") (:form . "SFS") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 169)\n  (:start . 159) (:id . 67))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 184)\n  (:start . 174) (:id . 69))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x199.9.1) (:span 48 56)))\n (:hscopes ((:id . :x199.9.1) (:span 48 76)))\n (:identifiers (:sid . :s199.9) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001763@unknown@formal@none@1@S@Comparison of group 1 human and mouse genomic sequences shows high conservation in the 5' flank and exons.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 79)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "flank") (:form . "flank") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s199.10) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001764@unknown@formal@none@1@S@A CpG island suggests expression in the germ line.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CpG") (:form . "CpG") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "germ") (:form . "germ") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x199.11.1) (:span 13 21)))\n (:hscopes ((:id . :x199.11.1) (:span 13 49)))\n (:identifiers (:sid . :s199.11) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001765@unknown@formal@none@1@S@G0S24 has potential sites for transcription factors in the 5' flank and intron;@(((:tag . "NN") (:stem . "g0s24") (:form . "G0S24") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "flank") (:form . "flank") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s199.12) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001766@unknown@formal@none@1@S@these include a serum response element.@(((:tag . "DT") (:stem . "these") (:form . "these") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s199.13) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001767@unknown@formal@none@1@S@Protein and genomic sequences show similarities with those of a variety of proteins involved in transcription, suggesting that the G0S24 product has a similar role.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 47)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "g0s24") (:form . "G0S24") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x199.14.1) (:span 111 121)))\n (:hscopes ((:id . :x199.14.1) (:span 111 163)))\n (:identifiers (:sid . :s199.14) (:did . :|93135830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001768@unknown@formal@none@1@S@Interleukin-4 inhibits the lipopolysaccharide-induced expression of c-jun and c-fos messenger RNA and activator protein-1 binding activity in human monocytes.@(((:tag . "NN") (:stem . "interleukin-4") (:form . "Interleukin-4")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 53) (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 73) (:start . 68)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 93)\n  (:start . 84) (:id . 51))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 97) (:start . 94)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 111)\n  (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 121)\n  (:start . 112) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 129)\n  (:start . 122) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 138)\n  (:start . 130) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 147)\n  (:start . 142) (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 157)\n  (:start . 148) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s200.1) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001770@unknown@formal@none@1@S@These genes encode proteins that form the dimeric complex activator protein-1 (AP-1), which is active as a transcriptional factor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dimeric") (:form . "dimeric") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 122) (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s200.3) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001771@unknown@formal@none@1@S@Maximal accumulation of either c-fos and c-jun messenger RNA (mRNA) occurred 30 minutes after LPS addition.@(((:tag . "JJ") (:stem . "maximal") (:form . "Maximal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s200.4) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001772@unknown@formal@none@1@S@When cells were treated with IL-4 for 5 hours before LPS activation, both the c-fos and the c-jun mRNA expression was decreased.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 127)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s200.5) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001773@unknown@formal@none@1@S@The inhibition of c-fos and c-jun expression by IL-4 in LPS-treated cells was shown to be due to a lower transcription rate of the c-fos and c-jun genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lps-treated") (:form . "LPS-treated") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 104) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 146)\n  (:start . 141) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s200.6) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001774@unknown@formal@none@1@S@IL-4 did not affect the stability of the c-fos and c-jun transcripts.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x200.7.1) (:span 9 12)))\n (:nscopes ((:id . :x200.7.1) (:span 9 68)))\n (:identifiers (:sid . :s200.7) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001775@unknown@formal@none@1@S@Finally, using electrophoretic mobility shift assays, evidence was obtained that IL-4 inhibits LPS-induced expression of AP-1 protein.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 30) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s200.8) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001776@unknown@formal@none@1@S@These data indicate that IL-4 suppresses the induction of transcription factors in human activated monocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x200.9.1) (:span 11 24)))\n (:hscopes ((:id . :x200.9.1) (:span 11 108)))\n (:identifiers (:sid . :s200.9) (:did . :|93136418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001777@unknown@formal@none@1@S@Ras oncogene transformation of human B lymphoblasts is associated with lymphocyte activation and with a block of differentiation.@(((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphoblast") (:form . "lymphoblasts") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 128) (:start . 113) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s201.1) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001778@unknown@formal@none@1@S@The p21ras small GTP binding proteins participate in signal transduction from cell surface receptors and affect neoplastic transformation and development in many different cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GTP") (:form . "GTP") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "JJ") (:stem . "neoplastic") (:form . "neoplastic") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 137) (:start . 123) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 153)\n  (:start . 142) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 161) (:start . 157)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 171)\n  (:start . 162) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 182)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s201.2) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001780@unknown@formal@none@1@S@We show that the constitutive expression of the T24 Ha-ras oncogene in EBV-immortalized B lymphoblasts was associated with the induction of the interleukin 2 receptor alpha subunit, with an impaired immunoglobulin gene expression, altered adhesion properties and increased survival in serum-free medium.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "T24") (:form . "T24") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ha-ras") (:form . "Ha-ras") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ebv-immortalized") (:form . "EBV-immortalized")\n  (:end . 87) (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphoblast") (:form . "lymphoblasts") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 155)\n  (:start . 144) (:id . 64))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 180)\n  (:start . 173) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 213) (:start . 199) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 218) (:start . 214)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 229)\n  (:start . 219) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 238)\n  (:start . 231) (:id . 77))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 247)\n  (:start . 239) (:id . 78))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 258)\n  (:start . 248) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 272)\n  (:start . 263) (:id . 81))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 281)\n  (:start . 273) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 284) (:start . 282)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "serum-free") (:form . "serum-free") (:end . 295)\n  (:start . 285) (:id . 84))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 302)\n  (:start . 296) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 303) (:start . 302)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s201.4) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001781@unknown@formal@none@1@S@Since induction of the IL-2 receptor alpha subunit is a hallmark of lymphocyte activation, we suggest that p21ras naturally triggers B cell activation.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hallmark") (:form . "hallmark") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x201.5.1) (:span 94 101)))\n (:hscopes ((:id . :x201.5.1) (:span 94 150)))\n (:identifiers (:sid . :s201.5) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001782@unknown@formal@none@1@S@The ras-transformed lymphocytes displayed a fully functional IL-2r, as assessed by c-fos induction following treatment with IL-2; nevertheless, they were not growth stimulated by this lymphokine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ras-transformed") (:form . "ras-transformed")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 46))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2r") (:form . "IL-2r") (:end . 66) (:start . 61)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 118)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "RB") (:stem . "nevertheless") (:form . "nevertheless") (:end . 142)\n  (:start . 130) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 194)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x201.6.1) (:span 154 157)))\n (:nscopes ((:id . :x201.6.1) (:span 144 194)))\n (:identifiers (:sid . :s201.6) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001783@unknown@formal@none@1@S@The decreased expression of immunoglobulin genes indicates that the ras oncogene blocks terminal differentiation to plasma cells, possibly by inhibiting the activity of lymphocyte-specific transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 42) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 112) (:start . 97) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 122)\n  (:start . 116) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 188) (:start . 169) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 202) (:start . 189) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 210)\n  (:start . 203) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x201.7.1) (:span 130 138))\n  ((:id . :x201.7.2) (:span 49 63)))\n (:hscopes ((:id . :x201.7.1) (:span 130 210))\n  ((:id . :x201.7.2) (:span 49 210)))\n (:identifiers (:sid . :s201.7) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001784@unknown@formal@none@1@S@Somewhat unexpectedly, the constitutive p21ras activity did not cause an increased DNA binding of transcription factors PEA1 (AP1), PEA3, Oct-2 or NF-kB.@(((:tag . "RB") (:stem . "somewhat") (:form . "Somewhat") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "unexpectedly") (:form . "unexpectedly") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "pea1") (:form . "PEA1") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PEA3") (:form . "PEA3") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Oct-2") (:form . "Oct-2") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x201.8.1) (:span 60 63)))\n (:nscopes ((:id . :x201.8.1) (:span 60 152)))\n (:identifiers (:sid . :s201.8) (:did . :|93141262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001785@unknown@formal@none@1@S@Transcription factor GATA-1 and erythroid development.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s202.1) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001786@unknown@formal@none@1@S@In summary, we derived an experimental system that allows us to dissect the function of GATA-1 in red cell development at a genetic level.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "derive") (:form . "derived") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 38)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VB") (:stem . "dissect") (:form . "dissect") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 118)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 131)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s202.2) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001787@unknown@formal@none@1@S@We have established the essential nature of GATA-1 during both primitive and definitive erythropoiesis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "definitive") (:form . "definitive") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 102) (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s202.3) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001788@unknown@formal@none@1@S@By ablating the expression of the endogenous GATA-1 gene, we are in a position to introduce a variety of constructs that harbor subtle modifications in flanking or protein-coding sequences.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "ablate") (:form . "ablating") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "VB") (:stem . "introduce") (:form . "introduce") (:end . 91)\n  (:start . 82) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 115)\n  (:start . 105) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "harbor") (:form . "harbor") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "JJ") (:stem . "subtle") (:form . "subtle") (:end . 134)\n  (:start . 128) (:id . 65))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 148) (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "protein-coding") (:form . "protein-coding")\n  (:end . 178) (:start . 164) (:id . 70))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 188)\n  (:start . 179) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s202.4) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001790@unknown@formal@none@1@S@Although the assay involves the dramatic loss of red cell production, it should be possible to define important regulatory domains that can then be assayed using less stringent systems, such as cell-free extracts for in vitro transcription.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 161) (:start . 156)\n  (:id . 68))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "stringent") (:form . "stringent") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 184)\n  (:start . 177) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 193) (:start . 191)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 203)\n  (:start . 194) (:id . 75))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 212)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 216) (:start . 213)\n  (:id . 77))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 78))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 225)\n  (:start . 220) (:id . 79))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 239) (:start . 226) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x202.6.1) (:span 83 91)) ((:id . :x202.6.2) (:span 73 79)))\n (:hscopes ((:id . :x202.6.1) (:span 83 239))\n  ((:id . :x202.6.2) (:span 73 239)))\n (:identifiers (:sid . :s202.6) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001791@unknown@formal@none@1@S@The ideal situation would be analyses conducted in GATA-1- erythroid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ideal") (:form . "ideal") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "situation") (:form . "situation") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata-1-") (:form . "GATA-1-") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x202.7.1) (:span 20 25)))\n (:hscopes ((:id . :x202.7.1) (:span 20 74)))\n (:identifiers (:sid . :s202.7) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001792@unknown@formal@none@1@S@However, these cells have been impossible to generate given the requirement of GATA-1 for Epo receptor expression and red cell viability (C. Simon and S. Orkin, unpublished observations).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "impossible") (:form . "impossible") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 75)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Simon") (:form . "Simon") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Orkin") (:form . "Orkin") (:end . 159)\n  (:start . 154) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 172)\n  (:start . 161) (:id . 71))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 185)\n  (:start . 173) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x202.8.1) (:span 31 41)))\n (:nscopes ((:id . :x202.8.1) (:span 9 53)))\n (:identifiers (:sid . :s202.8) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001793@unknown@formal@none@1@S@It may be possible to produce such cells by first expressing the Epo receptor under the influence of a constitutive promoter and then targeting the GATA-1 gene.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 115)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "target") (:form . "targeting") (:end . 143)\n  (:start . 134) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 154)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x202.9.1) (:span 10 18)) ((:id . :x202.9.2) (:span 3 6)))\n (:hscopes ((:id . :x202.9.1) (:span 10 159))\n  ((:id . :x202.9.2) (:span 3 159)))\n (:identifiers (:sid . :s202.9) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001794@unknown@formal@none@1@S@If GATA-1- red cells were available, the analyses would involve the actual transcription of or chromatin structure surrounding the globin genes.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1-") (:form . "GATA-1-") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "VBG") (:stem . "surround") (:form . "surrounding") (:end . 126)\n  (:start . 115) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x202.10.1) (:span 50 55)))\n (:hscopes ((:id . :x202.10.1) (:span 50 143)))\n (:identifiers (:sid . :s202.10) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001795@unknown@formal@none@1@S@Structure-function studies of the GATA-1 protein could be greatly simplified and a larger number of mutants studied.@(((:tag . "JJ") (:stem . "structure-function") (:form . "Structure-function")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "VBN") (:stem . "simplify") (:form . "simplified") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x202.11.1) (:span 49 54)))\n (:hscopes ((:id . :x202.11.1) (:span 0 115)))\n (:identifiers (:sid . :s202.11) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001796@unknown@formal@none@1@S@However, the ES cell system can be used as an alternative until targeted erythroleukemia cells become available.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alternative") (:form . "alternative") (:end . 57)\n  (:start . 46) (:id . 53))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 88) (:start . 73) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x202.12.1) (:span 28 31)))\n (:hscopes ((:id . :x202.12.1) (:span 9 111)))\n (:identifiers (:sid . :s202.12) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001797@unknown@formal@none@1@S@Other applications involve the introduction of other GATA-binding protein family members to determine whether they rescue the mutation.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "application") (:form . "applications") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "introduction") (:form . "introduction") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "rescue") (:form . "rescue") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x202.13.1) (:span 102 109)))\n (:hscopes ((:id . :x202.13.1) (:span 102 134)))\n (:identifiers (:sid . :s202.13) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001798@unknown@formal@none@1@S@If they can not, chimeric proteins can be tested to identify which amino acids distinguish the different family members.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 25)\n  (:start . 17) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 48) (:start . 42)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "distinguish") (:form . "distinguish") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x202.14.1) (:span 8 15)))\n (:nscopes ((:id . :x202.14.1) (:span 8 15)))\n (:identifiers (:sid . :s202.14) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001800@unknown@formal@none@1@S@How does GATA-1 regulate red cell genes like globin or the Epo receptor?@(((:tag . "WRB") (:stem . "how") (:form . "How") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s202.16) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001801@unknown@formal@none@1@S@Once we identify the functional domains of the GATA-binding proteins, we hope to learn what proteins GATA-1 binds to in the basic transcription machinery or in chromatin.@(((:tag . "RB") (:stem . "once") (:form . "Once") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "hope") (:form . "hope") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VB") (:stem . "learn") (:form . "learn") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "WP") (:stem . "what") (:form . "what") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 143) (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 169)\n  (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x202.17.1) (:span 73 77)))\n (:hscopes ((:id . :x202.17.1) (:span 73 169)))\n (:identifiers (:sid . :s202.17) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001802@unknown@formal@none@1@S@Is GATA-1 necessary for globin gene switching?@(((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 46) (:start . 45)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s202.18) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001803@unknown@formal@none@1@S@GATA-1 may be modified differently during development so that the locus control region can interact with different globin promoters.@(((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "so") (:form . "so") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x202.19.1) (:span 7 10)))\n (:hscopes ((:id . :x202.19.1) (:span 0 131)))\n (:identifiers (:sid . :s202.19) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001804@unknown@formal@none@1@S@We may find that one region of the protein is required for embryonic expression and another for adult globin gene expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x202.20.1) (:span 3 6)))\n (:hscopes ((:id . :x202.20.1) (:span 3 124)))\n (:identifiers (:sid . :s202.20) (:did . :|93141620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001805@unknown@formal@none@1@S@The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "restrict") (:form . "restricts") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 89) (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s203.1) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001806@unknown@formal@none@1@S@We have isolated cDNA clones of myeloid differentiation primary response (MyD) genes, activated in the absence of de novo protein synthesis following induction for differentiation along either the macrophage or granulocyte lineage in human myeloblastic leukemia HL-60 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MyD") (:form . "MyD") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 139)\n  (:start . 130) (:id . 65))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 149)\n  (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 179) (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 192)\n  (:start . 186) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 207)\n  (:start . 197) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 210) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 222)\n  (:start . 211) (:id . 75))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 230)\n  (:start . 223) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 239)\n  (:start . 234) (:id . 78))\n ((:tag . "JJ") (:stem . "myeloblastic") (:form . "myeloblastic") (:end . 252)\n  (:start . 240) (:id . 79))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 261)\n  (:start . 253) (:id . 80))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 267)\n  (:start . 262) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 273)\n  (:start . 268) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s203.2) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001807@unknown@formal@none@1@S@One cDNA clone of a primary response gene, expressed upon macrophage differentiation, encoded for Egr-1, a zinc finger transcription factor.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 84) (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s203.3) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001808@unknown@formal@none@1@S@The Egr-1 gene was observed to be transcriptionally silent in HL-60 cells, but active in U-937 and M1 cells, the latter two being predetermined for macrophage differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 51) (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "silent") (:form . "silent") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "m1") (:form . "M1") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 119)\n  (:start . 113) (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 129) (:start . 124)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "predetermine") (:form . "predetermined")\n  (:end . 143) (:start . 130) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 158)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 174) (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s203.4) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001810@unknown@formal@none@1@S@HL-60 cells constitutively expressing an Egr-1 transgene (HL-60Egr-1) could be induced for macrophage, but not granulocyte, differentiation.@(((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hl-60egr-1") (:form . "HL-60Egr-1") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 139) (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x203.6.2) (:span 70 75)))\n (:ncues ((:id . :x203.6.1) (:span 107 110)))\n (:hscopes ((:id . :x203.6.2) (:span 0 139)))\n (:nscopes ((:id . :x203.6.1) (:span 107 122)))\n (:identifiers (:sid . :s203.6) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001811@unknown@formal@none@1@S@These observations indicate that expression of Egr-1 is essential for and restricts differentiation of myeloblasts along the macrophage lineage.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "restrict") (:form . "restricts") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 99) (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "myeloblast") (:form . "myeloblasts") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 143)\n  (:start . 136) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x203.7.1) (:span 19 32)))\n (:hscopes ((:id . :x203.7.1) (:span 19 143)))\n (:identifiers (:sid . :s203.7) (:did . :|93145322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001812@unknown@formal@none@1@S@Activation of lymphokine genes in T cells: role of cis-acting DNA elements that respond to T cell activation signals.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s204.1) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001813@unknown@formal@none@1@S@Activation of T cells is initiated by the recognition of antigen on antigen presenting cells to exert the effector functions in immune and inflammatory responses.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "presenting") (:form . "presenting") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 151)\n  (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s204.2) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001814@unknown@formal@none@1@S@Two types of helper T cell (Th) clones (Th1 and Th2) are defined on the basis of different patterns of cytokine (lymphokine) secretion.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 38)\n  (:start . 32) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Th1") (:form . "Th1") (:end . 43) (:start . 40)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Th2") (:form . "Th2") (:end . 51) (:start . 48)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 64)\n  (:start . 57) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 60))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 77) (:start . 72)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 90)\n  (:start . 81) (:id . 63))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 99)\n  (:start . 91) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 111)\n  (:start . 103) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 123)\n  (:start . 113) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 69))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 134)\n  (:start . 125) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s204.3) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001815@unknown@formal@none@1@S@They determine the outcome of an antigenic response toward humoral or cell-mediated immunity.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "determine") (:form . "determine") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "outcome") (:form . "outcome") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "humoral") (:form . "humoral") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s204.4) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001816@unknown@formal@none@1@S@Although lymphokine genes are coordinately regulated upon antigen stimulation, they are regulated by the mechanisms common to all as well as those which are unique to each gene.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 77)\n  (:start . 66) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s204.5) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001817@unknown@formal@none@1@S@For most lymphokine genes, a combination of phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187) is required for their maximal induction.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "ionophore") (:form . "ionophores") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "A23187") (:form . "A23187") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 159)\n  (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 169)\n  (:start . 160) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s204.6) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001818@unknown@formal@none@1@S@Yet phorbol ester alone or calcium ionophore alone produce several lymphokines.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "lymphokine") (:form . "lymphokines") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s204.7) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001820@unknown@formal@none@1@S@We have previously found a cis-acting region spanning the GM-CSF promoter region (positions -95 to +27) that confers inducibility to reporter genes in transient transfection assays.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "VBG") (:stem . "span") (:form . "spanning") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "CD") (:stem . "-95") (:form . "-95") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "CD") (:stem . "+27") (:form . "+27") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 129)\n  (:start . 117) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 173)\n  (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 180)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s204.9) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001821@unknown@formal@none@1@S@Further analysis identified three elements required for efficient induction, referred to as GM2, GC-box and conserved lymphokine element (CLE0).@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gm2") (:form . "GM2") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gc-box") (:form . "GC-box") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s204.10) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001822@unknown@formal@none@1@S@GM2 defines a binding site for protein ( s ) whose binding is inducible by PMA.@(((:tag . "NNP") (:stem . "GM2") (:form . "GM2") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "define") (:form . "defines") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 71)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s204.11) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001823@unknown@formal@none@1@S@One protein, NF-GM2 is similar to the transcription factor NF-kB.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nf-gm2") (:form . "NF-GM2") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "nf-kb") (:form . "NF-kB") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s204.12) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001824@unknown@formal@none@1@S@GC-box is a binding site for constitutively bound proteins.@(((:tag . "NNP") (:stem . "GC-box") (:form . "GC-box") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 43) (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s204.13) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001825@unknown@formal@none@1@S@CLEO defines a binding site for protein ( s ) whose optimum binding is stimulated by PMA and A23187.@(((:tag . "NN") (:stem . "cleo") (:form . "CLEO") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "define") (:form . "defines") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "optimum") (:form . "optimum") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "A23187") (:form . "A23187") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s204.14) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001826@unknown@formal@none@1@S@Viral trans-activators such as Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV) proteins are other agents which activate lymphokine gene expression by bypassing T cell receptor (TCR) mediated signaling.@(((:tag . "JJ") (:stem . "viral") (:form . "Viral") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "trans-activator") (:form . "trans-activators")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "virus-1") (:form . "virus-1") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 89)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "papilloma") (:form . "papilloma") (:end . 99)\n  (:start . 90) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BPV") (:form . "BPV") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 120)\n  (:start . 112) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 130)\n  (:start . 125) (:id . 67))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 137)\n  (:start . 131) (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 143)\n  (:start . 138) (:id . 69))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 152)\n  (:start . 144) (:id . 70))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 163)\n  (:start . 153) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 179)\n  (:start . 169) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "bypass") (:form . "bypassing") (:end . 192)\n  (:start . 183) (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 194) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 208)\n  (:start . 200) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 213) (:start . 210)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 214) (:start . 213)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 223)\n  (:start . 215) (:id . 82))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 233)\n  (:start . 224) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s204.15) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001827@unknown@formal@none@1@S@The trans-activation domain of E2 and Tax is interchangeable although they have no obvious sequence homology between them.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "E2") (:form . "E2") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "interchangeable") (:form . "interchangeable")\n  (:end . 60) (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x204.16.1) (:span 80 82)))\n (:nscopes ((:id . :x204.16.1) (:span 80 121)))\n (:identifiers (:sid . :s204.16) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001828@unknown@formal@none@1@S@The viral trans-activators appear to target specific DNA binding protein such as NF-kB and Sp1 to cis-acting DNA site and promote lymphokine gene expression without TCR-mediated stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "trans-activator") (:form . "trans-activators")\n  (:end . 26) (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VB") (:stem . "target") (:form . "target") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 177)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 189)\n  (:start . 178) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x204.17.2) (:span 27 33)))\n (:ncues ((:id . :x204.17.1) (:span 157 164)))\n (:hscopes ((:id . :x204.17.2) (:span 0 189)))\n (:nscopes ((:id . :x204.17.1) (:span 157 189)))\n (:identifiers (:sid . :s204.17) (:did . :|93150054|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001830@unknown@formal@none@1@S@Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia.@(((:tag . "NN") (:stem . "tal-1") (:form . "Tal-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 20) (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 82) (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s205.2) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001831@unknown@formal@none@1@S@Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain and is known to be predominantly expressed in hematopoietic cells.@(((:tag . "NN") (:stem . "tal-1") (:form . "Tal-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 80) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 120) (:start . 107) (:id . 59))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 147) (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x205.3.1) (:span 21 29)))\n (:hscopes ((:id . :x205.3.1) (:span 21 50)))\n (:identifiers (:sid . :s205.3) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001832@unknown@formal@none@1@S@We investigated the pattern of tal-1 expression in purified human hematopoietic cells by in situ hybridization and reverse transcriptase polymerase chain reaction analysis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 110) (:start . 97) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "transcriptase") (:form . "transcriptase")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 153)\n  (:start . 148) (:id . 62))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 162)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 171)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s205.4) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001833@unknown@formal@none@1@S@Both methods demonstrated that the tal-1 gene is expressed in megakaryocytes and erythroblasts as well as in basophilic granulocytes.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 76) (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 94) (:start . 81) (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "basophilic") (:form . "basophilic") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 132)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s205.5) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001834@unknown@formal@none@1@S@In addition, our results indicate that the tal-1 1A promoter, which contains two consensus GATA-binding sites, is active mainly in these lineages.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 120)\n  (:start . 114) (:id . 62))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x205.6.1) (:span 25 38)))\n (:hscopes ((:id . :x205.6.1) (:span 25 145)))\n (:identifiers (:sid . :s205.6) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001835@unknown@formal@none@1@S@Because the GATA-1 gene is known to transactivate several genes specific for the erythroid, megakaryocytic, and mastocytic/basophilic lineages, we studied GATA-1 expression in these purified hematopoietic cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 106) (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mastocytic/basophilic")\n  (:form . "mastocytic/basophilic") (:end . 133) (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 172)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 190)\n  (:start . 182) (:id . 69))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 204) (:start . 191) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 210)\n  (:start . 205) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s205.7) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001836@unknown@formal@none@1@S@We found that GATA-1 and tal-1 genes are coexpressed in these three lineages.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s205.8) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001837@unknown@formal@none@1@S@Remarkably, the expression of both genes is downmodulated during erythroid and megakaryocytic terminal maturation.@(((:tag . "RB") (:stem . "remarkably") (:form . "Remarkably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "downmodulate") (:form . "downmodulated")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 93) (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 113)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s205.9) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001838@unknown@formal@none@1@S@In immature hematopoietic cells, tal-1 and GATA-1 genes are coexpressed in committed progenitors cells (CD34+/CD38(2+)), whereas they are not detectable in the most primitive cells (CD34(2+)/CD38-).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "commit") (:form . "committed") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD34+/CD38(2+))") (:form . "CD34+/CD38(2+))")\n  (:end . 119) (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 180)\n  (:start . 175) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "CD34(2+)/CD38-)") (:form . "CD34(2+)/CD38-)")\n  (:end . 197) (:start . 182) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x205.10.1) (:span 138 141)))\n (:nscopes ((:id . :x205.10.1) (:span 138 197)))\n (:identifiers (:sid . :s205.10) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001840@unknown@formal@none@1@S@Altogether our results strongly suggest that GATA-1 modulates the transcription of tal-1 during the differentiation of the erythroid, megakaryocytic, and basosophilic lineages.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 115) (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 148) (:start . 134) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "basosophilic") (:form . "basosophilic") (:end . 166)\n  (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 175)\n  (:start . 167) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x205.12.1) (:span 32 39)))\n (:hscopes ((:id . :x205.12.1) (:span 32 175)))\n (:identifiers (:sid . :s205.12) (:did . :|93152834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001841@unknown@formal@none@1@S@Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV-I) tax and HTLV-II tax proteins.@(((:tag . "JJ") (:stem . "cell-type-specific") (:form . "Cell-type-specific")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 34) (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "parathyroid") (:form . "parathyroid") (:end . 53)\n  (:start . 42) (:id . 46))\n ((:tag . "JJ") (:stem . "hormone-related") (:form . "hormone-related")\n  (:end . 69) (:start . 54) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 111)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 120)\n  (:start . 112) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 126)\n  (:start . 121) (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 131) (:start . 127)\n  (:id . 57))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HTLV-II") (:form . "HTLV-II") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s206.1) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001842@unknown@formal@none@1@S@The human T-cell leukemia virus type I (HTLV-I) and HTLV-II Tax proteins are potent transactivators of viral and cellular gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-II") (:form . "HTLV-II") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 99) (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s206.2) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001843@unknown@formal@none@1@S@Using deletion mutants, the downstream parathyroid hormone-related protein (PTHrP) promoter is shown to be responsive to both HTLV-I and HTLV-II Tax as well as the AP1/c-jun proto-oncogene.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "parathyroid") (:form . "parathyroid") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "hormone-related") (:form . "hormone-related")\n  (:end . 66) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PTHrP") (:form . "PTHrP") (:end . 81) (:start . 76)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HTLV-II") (:form . "HTLV-II") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "AP1/c-jun") (:form . "AP1/c-jun") (:end . 173)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 188) (:start . 174) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s206.3) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001844@unknown@formal@none@1@S@Transactivation of PTHrP by Tax was seen in T cells but not in B-cell lines or fibroblasts.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PTHrP") (:form . "PTHrP") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 90)\n  (:start . 79) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x206.4.1) (:span 56 59)))\n (:nscopes ((:id . :x206.4.1) (:span 56 90)))\n (:identifiers (:sid . :s206.4) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001845@unknown@formal@none@1@S@A carboxy terminal Tax deletion mutant was deficient in transactivation of both the PTHrP and IL2R alpha promoters but not the HTLV-I long terminal repeat (LTR).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "carboxy") (:form . "carboxy") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 71) (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PTHrP") (:form . "PTHrP") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL2R") (:form . "IL2R") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x206.5.1) (:span 119 122)))\n (:nscopes ((:id . :x206.5.1) (:span 119 160)))\n (:identifiers (:sid . :s206.5) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001846@unknown@formal@none@1@S@Exogenous provision of NFkB rescued IL2R alpha expression but not the PTHrP promoter.@(((:tag . "JJ") (:stem . "exogenous") (:form . "Exogenous") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "provision") (:form . "provision") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFkB") (:form . "NFkB") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "IL2R") (:form . "IL2R") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PTHrP") (:form . "PTHrP") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x206.6.1) (:span 62 65)))\n (:nscopes ((:id . :x206.6.1) (:span 62 84)))\n (:identifiers (:sid . :s206.6) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001847@unknown@formal@none@1@S@Thus, HTLV-I Tax, HTLV-II Tax, and c-jun transactivate PTHrP and may contribute to the pathogenesis of hypercalcemia in adult T-cell leukemia.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 12)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HTLV-II") (:form . "HTLV-II") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 40) (:start . 35)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 54) (:start . 41) (:id . 52))\n ((:tag . "NNP") (:stem . "PTHrP") (:form . "PTHrP") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 99)\n  (:start . 87) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hypercalcemia") (:form . "hypercalcemia")\n  (:end . 116) (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x206.7.1) (:span 65 68)))\n (:hscopes ((:id . :x206.7.1) (:span 65 141)))\n (:identifiers (:sid . :s206.7) (:did . :|93152870|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001848@unknown@formal@none@1@S@Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.@(((:tag . "NN") (:stem . "interleukin-3") (:form . "Interleukin-3")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 84) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s207.1) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001850@unknown@formal@none@1@S@We have investigated the protein binding characteristics and functional importance of the ACT-1-activating region of the IL-3 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "act-1-activating") (:form . "ACT-1-activating")\n  (:end . 106) (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 113)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s207.3) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001851@unknown@formal@none@1@S@This region binds an inducible, T-cell-specific factor over its 5' end, a site that is necessary for the expression of IL-3 in the absence of other upstream elements.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 47) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 96)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 123) (:start . 119)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 138)\n  (:start . 131) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 147)\n  (:start . 142) (:id . 70))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 156)\n  (:start . 148) (:id . 71))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 165)\n  (:start . 157) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s207.4) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001852@unknown@formal@none@1@S@Over its 3' end, it binds a factor that is ubiquitously and constitutively expressed.@(((:tag . "IN") (:stem . "over") (:form . "Over") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 19) (:start . 17)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 25) (:start . 20)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 53))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 55)\n  (:start . 43) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 74) (:start . 60) (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s207.5) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001853@unknown@formal@none@1@S@This factor is Oct-1 or an immunologically related octamer-binding protein, and it plays a role in coordinating the activity of several regulatory elements.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 42) (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 66) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "coordinate") (:form . "coordinating") (:end . 111)\n  (:start . 99) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x207.6.1) (:span 21 23)))\n (:hscopes ((:id . :x207.6.1) (:span 15 74)))\n (:identifiers (:sid . :s207.6) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001854@unknown@formal@none@1@S@These characteristics make the ACT-1 site analogous to the activating ARRE-1 site in the IL-2 promoter.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "act-1") (:form . "ACT-1") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "arre-1") (:form . "ARRE-1") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s207.7) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001855@unknown@formal@none@1@S@Furthermore, and despite a lack of sequence homology, the promoters of IL-3 and IL-2 share an organizational pattern of regulatory elements that is likely to be important for the T-cell-specific expression of these genes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "organizational") (:form . "organizational")\n  (:end . 108) (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 130)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 154)\n  (:start . 148) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 194) (:start . 179) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 205)\n  (:start . 195) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 214)\n  (:start . 209) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 220)\n  (:start . 215) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x207.8.1) (:span 148 154)))\n (:ncues ((:id . :x207.8.2) (:span 27 31)))\n (:hscopes ((:id . :x207.8.1) (:span 140 220)))\n (:nscopes ((:id . :x207.8.2) (:span 27 52)))\n (:identifiers (:sid . :s207.8) (:did . :|93152894|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001856@unknown@formal@none@1@S@I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.@(((:tag . "NN") (:stem . "i") (:form . "I") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "b/mad-3") (:form . "B/MAD-3") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "mask") (:form . "masks") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 104) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s208.1) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001857@unknown@formal@none@1@S@The active nuclear form of the NF-kappa B transcription factor complex is composed of two DNA binding subunits, NF-kappa B p65 and NF-kappa B p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 139)\n  (:start . 131) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 176)\n  (:start . 167) (:id . 73))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 187)\n  (:start . 177) (:id . 74))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 196)\n  (:start . 188) (:id . 75))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 205)\n  (:start . 197) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 210) (:start . 206)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "NN") (:stem . "v-rel") (:form . "v-rel") (:end . 220)\n  (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 237)\n  (:start . 230) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s208.2) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001858@unknown@formal@none@1@S@The NF-kappa B p65 subunit provides the transactivation activity in this complex and serves as an intracellular receptor for a cytoplasmic inhibitor of NF-kappa B, termed I kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 138)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s208.3) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001860@unknown@formal@none@1@S@To investigate the molecular basis for the critical regulatory interaction between NF-kappa B and I kappa B/MAD-3, a series of human NF-kappa B p65 mutants was identified that functionally segregated DNA binding, I kappa B-mediated inhibition, and I kappa B-induced nuclear exclusion of this transcription factor.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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5001861@unknown@formal@none@1@S@Results from in vivo expression studies performed with these NF-kappa B p65 mutants revealed the following:@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "following") (:form . "following") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s208.6) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001862@unknown@formal@none@1@S@1 ) I kappa B/MAD-3 completely inhibits NF-kappa B p65-dependent transcriptional activation mediated through the human immunodeficiency virus type 1 kappa B enhancer in human T lymphocytes, 2 ) the binding of I kappa B/MAD-3 to NF-kappa B p65 is sufficient to retarget NF-kappa B p65 from the nucleus to the cytoplasm, 3 ) selective deletion of the functional nuclear localization signal present in the Rel homology domain of NF-kappa B p65 disrupts its ability to engage I kappa B/MAD-3, and 4 ) the unique C-terminus of NF-kappa B p65 attenuates its own nuclear localization and contains sequences that are required for I kappa B-mediated inhibition of NF-kappa B p65 DNA binding activity.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 5) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . 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5001863@unknown@formal@none@1@S@Together, these findings suggest that the nuclear localization signal and transactivation domain of NF-kappa B p65 constitute a bipartite system that is critically involved in the inhibitory function of I kappa B/MAD-3.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 89) (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 163)\n  (:start . 153) (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 172)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 190)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 199)\n  (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 204) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "NN") (:stem . "b/mad-3") (:form . "B/MAD-3") (:end . 218)\n  (:start . 211) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x208.8.1) (:span 25 32)))\n (:hscopes ((:id . :x208.8.1) (:span 25 218)))\n (:identifiers (:sid . :s208.8) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001864@unknown@formal@none@1@S@Unexpectedly, our in vivo studies also demonstrate that I kappa B/MAD-3 binds directly to NF-kappa B p50.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b/mad-3") (:form . "B/MAD-3") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s208.9) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001865@unknown@formal@none@1@S@This interaction is functional as it leads to retargeting of NF-kappa B p50 from the nucleus to the cytoplasm.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "retargeting") (:form . "retargeting") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s208.10) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001866@unknown@formal@none@1@S@However, no loss of DNA binding activity is observed, presumably reflecting the unique C-terminal domain that is distinct from that present in NF-kappa B p65.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x208.11.1) (:span 54 64)))\n (:ncues ((:id . :x208.11.2) (:span 9 11)))\n (:hscopes ((:id . :x208.11.1) (:span 54 157)))\n (:nscopes ((:id . :x208.11.2) (:span 9 52)))\n (:identifiers (:sid . :s208.11) (:did . :|93153017|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001867@unknown@formal@none@1@S@Surrogate thyroglobulin receptors and T cell proliferation in Hashimoto 's thyroiditis.@(((:tag . "JJ") (:stem . "surrogate") (:form . "Surrogate") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "thyroglobulin") (:form . "thyroglobulin")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 33)\n  (:start . 24) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 58) (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Hashimoto") (:form . "Hashimoto") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thyroiditis") (:form . "thyroiditis") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s209.1) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001868@unknown@formal@none@1@S@Immunoglobulin molecules on the surface of a B lymphocyte are the endogenous " receptors " to which specific antigens bind.@(((:tag . "NNP") (:stem . "Immunoglobulin") (:form . "Immunoglobulin")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s209.2) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001870@unknown@formal@none@1@S@We have investigated whether a palmitate conjugate of a human monoclonal antibody specific for thyroglobulin (TG) could function as a surrogate TG receptor on blood mononuclear cells separated into fractions enriched for T cells or depleted of T cells (non-T cells).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "palmitate") (:form . "palmitate") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "conjugate") (:form . "conjugate") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thyroglobulin") (:form . "thyroglobulin")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "tg") (:form . "TG") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 164)\n  (:start . 159) (:id . 68))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 176)\n  (:start . 165) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 192)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 197) (:start . 193)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 207)\n  (:start . 198) (:id . 73))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 216)\n  (:start . 208) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 220) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 222) (:start . 221)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 228)\n  (:start . 223) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 231) (:start . 229)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "deplete") (:form . "depleted") (:end . 240)\n  (:start . 232) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 80))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 245) (:start . 244)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 251)\n  (:start . 246) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 253) (:start . 252)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 258)\n  (:start . 253) (:id . 84))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 264)\n  (:start . 259) (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 265) (:start . 264)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x209.4.1) (:span 114 119))\n  ((:id . :x209.4.2) (:span 21 28)))\n (:hscopes ((:id . :x209.4.1) (:span 114 265))\n  ((:id . :x209.4.2) (:span 21 265)))\n (:identifiers (:sid . :s209.4) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001871@unknown@formal@none@1@S@Using flow cytometry, we detected surrogate TG receptors on non-T ( but not on T) cells from 11 of 11 individuals studied (5 Hashimoto patients and 6 control donors).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "tg") (:form . "TG") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 60))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 95) (:start . 93)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 101) (:start . 99)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 113)\n  (:start . 102) (:id . 64))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 121)\n  (:start . 114) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 66))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 124) (:start . 123)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Hashimoto") (:form . "Hashimoto") (:end . 134)\n  (:start . 125) (:id . 68))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 143)\n  (:start . 135) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 70))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 149) (:start . 148)\n  (:id . 71))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 157)\n  (:start . 150) (:id . 72))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 164)\n  (:start . 158) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x209.5.1) (:span 72 75)))\n (:nscopes ((:id . :x209.5.1) (:span 72 80)))\n (:identifiers (:sid . :s209.5) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001872@unknown@formal@none@1@S@In contrast, endogenous TG receptors could only be detected on non-T cells from 1 of 3 Hashimoto patients and from 0 of 4 control donors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Hashimoto") (:form . "Hashimoto") (:end . 96)\n  (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 129)\n  (:start . 122) (:id . 66))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 136)\n  (:start . 130) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s209.6) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001873@unknown@formal@none@1@S@Because of the efficient binding of TG by surrogate receptors on non-T cells, we assessed the ability of such cells to present TG to T cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tg") (:form . "TG") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "assess") (:form . "assessed") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "VB") (:stem . "present") (:form . "present") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "tg") (:form . "TG") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s209.7) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001874@unknown@formal@none@1@S@Proliferation in response to TG was observed in T cells from only 1 of 5 Hashimoto patients.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Hashimoto") (:form . "Hashimoto") (:end . 82)\n  (:start . 73) (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s209.8) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001875@unknown@formal@none@1@S@This low frequency of response was no different from that previously detected using cultures of T cells and autologous dendritic cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "autologous") (:form . "autologous") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x209.9.1) (:span 35 37)))\n (:nscopes ((:id . :x209.9.1) (:span 35 134)))\n (:identifiers (:sid . :s209.9) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001876@unknown@formal@none@1@S@Therefore, the successful generation of surrogate receptors on non-T cells is not associated with more efficient TG presentation of T cells.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "tg") (:form . "TG") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x209.10.1) (:span 78 81)))\n (:nscopes ((:id . :x209.10.1) (:span 11 139)))\n (:identifiers (:sid . :s209.10) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001877@unknown@formal@none@1@S@Furthermore, the significance of the present study is that the T cells, not the antigen-presenting cells, are likely to be the limiting element in the T cell proliferative response to TG and other thyroid autoantigens.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 98) (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 171) (:start . 158) (:id . 72))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 180)\n  (:start . 172) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 186) (:start . 184)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 196)\n  (:start . 191) (:id . 77))\n ((:tag . "JJ") (:stem . "thyroid") (:form . "thyroid") (:end . 204)\n  (:start . 197) (:id . 78))\n ((:tag . "NNS") (:stem . "autoantigen") (:form . "autoantigens") (:end . 217)\n  (:start . 205) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x209.11.1) (:span 110 116)))\n (:ncues ((:id . :x209.11.2) (:span 72 75)))\n (:hscopes ((:id . :x209.11.1) (:span 106 217)))\n (:nscopes ((:id . :x209.11.2) (:span 72 104)))\n (:identifiers (:sid . :s209.11) (:did . :|93153207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001878@unknown@formal@none@1@S@The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "cis-element") (:form . "cis-element") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s210.1) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001880@unknown@formal@none@1@S@We have shown previously that EBNA2 transactivates the promoters of the latent membrane antigens LMP, TP1 and TP2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "transactivate") (:form . "transactivates")\n  (:end . 50) (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TP1") (:form . "TP1") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TP2") (:form . "TP2") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s210.3) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001881@unknown@formal@none@1@S@The promoter of the TP1 gene was chosen as a model system to study the molecular mechanism of EBNA2 mediated transactivation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tp1") (:form . "TP1") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 80)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 124) (:start . 109) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s210.4) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001882@unknown@formal@none@1@S@To identify an EBNA2 dependent cis-acting element, various TP1 promoter-reporter gene constructs were transfected in the absence and presence of an EBNA2 expression vector into the established B-cell line BL41-P3HR1.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "tp1") (:form . "TP1") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter-reporter") (:form . "promoter-reporter")\n  (:end . 80) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 171)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "established") (:form . "established") (:end . 192)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 199)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 204) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "bl41-p3hr1") (:form . "BL41-P3HR1") (:end . 215)\n  (:start . 205) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s210.5) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001883@unknown@formal@none@1@S@We were able to delineate an 81 bp EBNA2 responsive region between -258 and -177 relative to the TP1 RNA start site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "CD") (:stem . "81") (:form . "81") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 51)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "CD") (:stem . "-258") (:form . "-258") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-177") (:form . "-177") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TP1") (:form . "TP1") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s210.6) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001884@unknown@formal@none@1@S@The element worked in either orientation and could mediate EBNA2 dependent transactivation on a heterologous promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "work") (:form . "worked") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 90) (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s210.7) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001885@unknown@formal@none@1@S@Electrophoretic mobility shift assays revealed three specific protein-DNA complexes formed with sequences of the EBNA2 responsive element.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 73)\n  (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 83)\n  (:start . 74) (:id . 50))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 90) (:start . 84)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 105)\n  (:start . 96) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 129)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 137)\n  (:start . 130) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s210.8) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001886@unknown@formal@none@1@S@Two of these were not cell type specific, but the third was detected only in EBNA2 positive cell extracts.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 82) (:start . 77)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 105)\n  (:start . 97) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x210.9.1) (:span 18 21)))\n (:nscopes ((:id . :x210.9.1) (:span 18 40)))\n (:identifiers (:sid . :s210.9) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001887@unknown@formal@none@1@S@Gel-shift analysis in the presence of EBNA2 specific monoclonal antibodies revealed that EBNA2 is a component of the third complex.@(((:tag . "JJ") (:stem . "gel-shift") (:form . "Gel-shift") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s210.10) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001888@unknown@formal@none@1@S@Thus, these experiments demonstrate that EBNA2 interacts with an EBNA2 responsive cis-element of the TP1 promoter.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "cis-element") (:form . "cis-element") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tp1") (:form . "TP1") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s210.11) (:did . :|93154317|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001890@unknown@formal@none@1@S@In a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with the lymphokine interleukin-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 11)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 60) (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "promoter/reporter") (:form . "promoter/reporter")\n  (:end . 78) (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "agonism") (:form . "agonism") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 150)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 184) (:start . 171) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s211.2) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001891@unknown@formal@none@1@S@Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbol esters in combination with calcium mobilization by an ionophore.@(((:tag . "NN") (:stem . "antigen") (:form . "Antigen") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mimic") (:form . "mimicked") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "suboptimal") (:form . "suboptimal") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 154)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s211.3) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001892@unknown@formal@none@1@S@In cotransfection experiments, oncogenic rats obviated the need for PKC stimulation but did not replace either the calcium signal or interleukin-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "obviate") (:form . "obviated") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "need") (:form . "need") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VB") (:stem . "replace") (:form . "replace") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 146) (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x211.4.1) (:span 92 95)))\n (:nscopes ((:id . :x211.4.1) (:span 92 146)))\n (:identifiers (:sid . :s211.4) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001893@unknown@formal@none@1@S@Activated ras expression also replaced the requirement for PKC stimulation in activation of the T-cell transcription factor NF-AT.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "replace") (:form . "replaced") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 102)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s211.5) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001894@unknown@formal@none@1@S@A dominant inhibitory ras mutant specifically blocked antigen receptor agonism, indicating that ras activity is required for antigen receptor signaling.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "agonism") (:form . "agonism") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x211.6.1) (:span 80 95)))\n (:hscopes ((:id . :x211.6.1) (:span 80 151)))\n (:identifiers (:sid . :s211.6) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001895@unknown@formal@none@1@S@In addition, an inhibitor of PKC blocked both activated ras and phorbol ester stimulation, suggesting a role for ras upstream of PKC.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x211.7.1) (:span 91 101)))\n (:hscopes ((:id . :x211.7.1) (:span 91 132)))\n (:identifiers (:sid . :s211.7) (:did . :|93155082|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001896@unknown@formal@none@1@S@Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 83) (:start . 66) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 111)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s212.1) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001897@unknown@formal@none@1@S@The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 43)\n  (:start . 36) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pre-existing") (:form . "pre-existing") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 155)\n  (:start . 145) (:id . 67))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 167)\n  (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 174)\n  (:start . 168) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 202)\n  (:start . 192) (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 210)\n  (:start . 203) (:id . 74))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 220)\n  (:start . 211) (:id . 75))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 227)\n  (:start . 221) (:id . 76))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 230) (:start . 228)\n  (:id . 77))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 234) (:start . 231)\n  (:id . 78))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 240)\n  (:start . 235) (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 251)\n  (:start . 241) (:id . 80))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 259)\n  (:start . 252) (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 263) (:start . 260)\n  (:id . 82))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 271)\n  (:start . 264) (:id . 83))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 280)\n  (:start . 272) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s212.2) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001898@unknown@formal@none@1@S@Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s212.3) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001900@unknown@formal@none@1@S@We further characterize which AP1 family members can assume this role.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "characterize") (:form . "characterize") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VB") (:stem . "assume") (:form . "assume") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s212.5) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001901@unknown@formal@none@1@S@Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.@(((:tag . "NNP") (:stem . "Antiserum") (:form . "Antisera") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 69) (:start . 54) (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s212.6) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001902@unknown@formal@none@1@S@Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 55) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "fra-1") (:form . "Fra-1") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "eliminate") (:form . "eliminates") (:end . 80)\n  (:start . 70) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 96)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 121)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 132)\n  (:start . 122) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 150)\n  (:start . 139) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "leave") (:form . "leaving") (:end . 159)\n  (:start . 152) (:id . 68))\n ((:tag . "JJ") (:stem . "nf-at-directed") (:form . "NF-AT-directed")\n  (:end . 174) (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 188) (:start . 175) (:id . 70))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 199)\n  (:start . 189) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 210)\n  (:start . 203) (:id . 73))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 220)\n  (:start . 211) (:id . 74))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 226)\n  (:start . 221) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s212.7) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001903@unknown@formal@none@1@S@Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cjun") (:form . "cJun") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "eliminate") (:form . "eliminates") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "jun-") (:form . "Jun-") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "fos-related") (:form . "Fos-related") (:end . 140)\n  (:start . 129) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 149)\n  (:start . 141) (:id . 68))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 162)\n  (:start . 150) (:id . 69))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "JJ") (:stem . "nf-at-dependent") (:form . "NF-AT-dependent")\n  (:end . 187) (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 201) (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 217)\n  (:start . 209) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 236)\n  (:start . 225) (:id . 78))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 246)\n  (:start . 237) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x212.8.2) (:span 87 102)))\n (:ncues ((:id . :x212.8.1) (:span 112 115))\n  ((:id . :x212.8.3) (:span 36 39)))\n (:hscopes ((:id . :x212.8.2) (:span 87 246)))\n (:nscopes ((:id . :x212.8.1) (:span 112 119))\n  ((:id . :x212.8.3) (:span 36 44)))\n (:identifiers (:sid . :s212.8) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001904@unknown@formal@none@1@S@NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.@(((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "semi-purified") (:form . "semi-purified")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "VBN") (:stem . "mix") (:form . "mixed") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s212.9) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001905@unknown@formal@none@1@S@Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.@(((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 27) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reconstitution") (:form . "reconstitution")\n  (:end . 51) (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 133)\n  (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x212.10.1) (:span 93 96)))\n (:ncues ((:id . :x212.10.2) (:span 74 77))\n  ((:id . :x212.10.3) (:span 17 20)))\n (:hscopes ((:id . :x212.10.1) (:span 93 141)))\n (:nscopes ((:id . :x212.10.2) (:span 74 88))\n  ((:id . :x212.10.3) (:span 17 51)))\n (:identifiers (:sid . :s212.10) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001906@unknown@formal@none@1@S@Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "show") (:form . "show") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "elution") (:form . "elution") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "renaturation") (:form . "renaturation") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SDS-polyacrylamide") (:form . "SDS-polyacrylamide")\n  (:end . 131) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 151) (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "gel") (:form . "gels") (:end . 156) (:start . 152)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 185) (:start . 181)\n  (:id . 69))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 193)\n  (:start . 186) (:id . 70))\n ((:tag . "CD") (:stem . "94") (:form . "94") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 72))\n ((:tag . "CD") (:stem . "116") (:form . "116") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 75))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 221) (:start . 217)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 230)\n  (:start . 222) (:id . 78))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 245) (:start . 231) (:id . 79))\n ((:tag . "JJ") (:stem . "modified") (:form . "modified") (:end . 254)\n  (:start . 246) (:id . 80))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 260)\n  (:start . 255) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x212.11.1) (:span 213 216)))\n (:hscopes ((:id . :x212.11.1) (:span 213 260)))\n (:identifiers (:sid . :s212.11) (:did . :|93155114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001907@unknown@formal@none@1@S@The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "p65-mediated") (:form . "p65-mediated") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 81) (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 104) (:start . 100)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 113)\n  (:start . 105) (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 120)\n  (:start . 114) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 153) (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 159)\n  (:start . 154) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s213.1) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001908@unknown@formal@none@1@S@The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1) and the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha) share functional kappa B enhancer elements involved in the regulation of these inducible transcription units during T-cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . 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"these") (:end . 265)\n  (:start . 260) (:id . 90))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 275)\n  (:start . 266) (:id . 91))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 289) (:start . 276) (:id . 92))\n ((:tag . "NNS") (:stem . "unit") (:form . "units") (:end . 295)\n  (:start . 290) (:id . 93))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 302)\n  (:start . 296) (:id . 94))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 309)\n  (:start . 303) (:id . 95))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 320)\n  (:start . 310) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 321) (:start . 320)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s213.2) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001910@unknown@formal@none@1@S@Recent biochemical studies have shown that p65 and p50 form the prototypical NF-kappa B complex, which is rapidly translocated from the cytoplasm to the nucleus during T-cell activation.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "prototypical") (:form . "prototypical") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 126)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 160)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 174)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 185)\n  (:start . 175) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s213.4) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001911@unknown@formal@none@1@S@This intracellular signaling complex potently stimulates kappa B-directed transcription from either the HIV-1 LTR or the IL-2R alpha promoter via the strong transactivation domain present in p65.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 56)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 62) (:start . 57)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "b-directed") (:form . "B-directed") (:end . 73)\n  (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 99)\n  (:start . 93) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 109)\n  (:start . 104) (:id . 54))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 132)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 172) (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 179)\n  (:start . 173) (:id . 65))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 187)\n  (:start . 180) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 194) (:start . 191)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x213.5.1) (:span 93 99 114 116)))\n (:hscopes ((:id . :x213.5.1) (:span 93 141)))\n (:identifiers (:sid . :s213.5) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001912@unknown@formal@none@1@S@We now demonstrate that nuclear expression of human c-Rel, which is induced by either phorbol ester or tumor necrosis factor alpha with delayed kinetics relative to p65, markedly represses p65-mediated activation of these transcription units.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 178)\n  (:start . 170) (:id . 71))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 188)\n  (:start . 179) (:id . 72))\n ((:tag . "JJ") (:stem . "p65-mediated") (:form . "p65-mediated") (:end . 201)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 212)\n  (:start . 202) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 221)\n  (:start . 216) (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 235) (:start . 222) (:id . 77))\n ((:tag . "NNS") (:stem . "unit") (:form . "units") (:end . 241)\n  (:start . 236) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s213.6) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001913@unknown@formal@none@1@S@These inhibitory effects of c-Rel correlate with its DNA-binding activity but not with its ability to heterodimerize with p50, suggesting that c-Rel inhibition involves competition with p50/p65 for occupancy of the kappa B enhancer element.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VB") (:stem . "heterodimerize") (:form . "heterodimerize")\n  (:end . 116) (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 159)\n  (:start . 149) (:id . 65))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 180)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 193)\n  (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 207)\n  (:start . 198) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 220)\n  (:start . 215) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 222) (:start . 221)\n  (:id . 75))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 231)\n  (:start . 223) (:id . 76))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 239)\n  (:start . 232) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x213.7.1) (:span 127 137)))\n (:ncues ((:id . :x213.7.2) (:span 78 81)))\n (:hscopes ((:id . :x213.7.1) (:span 127 239)))\n (:nscopes ((:id . :x213.7.2) (:span 78 125)))\n (:identifiers (:sid . :s213.7) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001914@unknown@formal@none@1@S@Together, these findings suggest that one function of c-Rel is as a physiologic repressor of the HIV-1 LTR and IL-2R alpha promoters, serving to efficiently counter the strong transcriptional activating effects of p65.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 102)\n  (:start . 97) (:id . 59))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "serve") (:form . "serving") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 156)\n  (:start . 145) (:id . 68))\n ((:tag . "VB") (:stem . "counter") (:form . "counter") (:end . 164)\n  (:start . 157) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 175)\n  (:start . 169) (:id . 71))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 191) (:start . 176) (:id . 72))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 202)\n  (:start . 192) (:id . 73))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 210)\n  (:start . 203) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 217) (:start . 214)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x213.8.1) (:span 25 32)))\n (:hscopes ((:id . :x213.8.1) (:span 25 217)))\n (:identifiers (:sid . :s213.8) (:did . :|93157335|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001915@unknown@formal@none@1@S@Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.@(((:tag . "NNP") (:stem . "Protease") (:form . "Protease") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "distinguish") (:form . "distinguishes") (:end . 52)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 66) (:start . 61)\n  (:id . 49))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "X1") (:form . "X1") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "JJ") (:stem . "ii-deficient") (:form . "II-deficient") (:end . 137)\n  (:start . 125) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s214.1) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001916@unknown@formal@none@1@S@The X box region is critical for directing the expression of class II major histocompatibility complex genes in B lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 94) (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s214.2) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001917@unknown@formal@none@1@S@Although several class II promoter-specific DNA binding factors have been described, only the X box region factor, RFX, shows a genetic correlation with class II expression, being deficient in some B cell lines derived from patients with class II-deficient congenital immunodeficiency.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promoter-specific") (:form . "promoter-specific")\n  (:end . 43) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 147)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 172)\n  (:start . 162) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 179) (:start . 174)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 74))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 197) (:start . 193)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 204) (:start . 200)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 210)\n  (:start . 205) (:id . 78))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 218)\n  (:start . 211) (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 223) (:start . 219)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 232)\n  (:start . 224) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 237) (:start . 233)\n  (:id . 82))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 243)\n  (:start . 238) (:id . 83))\n ((:tag . "JJ") (:stem . "ii-deficient") (:form . "II-deficient") (:end . 256)\n  (:start . 244) (:id . 84))\n ((:tag . "JJ") (:stem . "congenital") (:form . "congenital") (:end . 267)\n  (:start . 257) (:id . 85))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 284) (:start . 268) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 285) (:start . 284)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s214.3) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001918@unknown@formal@none@1@S@To further evaluate the role of X box DNA-binding proteins in class II gene expression, the role of the X box region was examined in both class II-positive and -negative lymphoid cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 116)\n  (:start . 110) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 137) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 143)\n  (:start . 138) (:id . 69))\n ((:tag . "JJ") (:stem . "ii-positive") (:form . "II-positive") (:end . 155)\n  (:start . 144) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "-negative") (:form . "-negative") (:end . 169)\n  (:start . 160) (:id . 72))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 178)\n  (:start . 170) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s214.4) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001920@unknown@formal@none@1@S@In contrast to wild-type B cells, neither of the class II mutant cell lines could use the X box region to direct the expression of a transiently transfected reporter gene, indicating that the X box-dependent transcriptional pathway is defective in these cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 102)\n  (:start . 96) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 63))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 112)\n  (:start . 106) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 68))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 144)\n  (:start . 133) (:id . 69))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 156)\n  (:start . 145) (:id . 70))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 165)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 182)\n  (:start . 172) (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 193) (:start . 192)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "box-dependent") (:form . "box-dependent")\n  (:end . 207) (:start . 194) (:id . 78))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 223) (:start . 208) (:id . 79))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 231)\n  (:start . 224) (:id . 80))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 234) (:start . 232)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 244)\n  (:start . 235) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 83))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 253)\n  (:start . 248) (:id . 84))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 259)\n  (:start . 254) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x214.6.1) (:span 172 187))\n  ((:id . :x214.6.2) (:span 76 81)))\n (:ncues ((:id . :x214.6.3) (:span 34 41)))\n (:hscopes ((:id . :x214.6.1) (:span 172 259))\n  ((:id . :x214.6.2) (:span 76 170)))\n (:nscopes ((:id . :x214.6.3) (:span 34 170)))\n (:identifiers (:sid . :s214.6) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001921@unknown@formal@none@1@S@The binding activity of the X1 box DNA-binding protein RFX was examined and found to be present in wild-type B cells and the mutant RJ2.2.5 but was absent in SJO and Jurkat.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "x1") (:form . "X1") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 131)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "rj2.2.5") (:form . "RJ2.2.5") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 154)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SJO") (:form . "SJO") (:end . 161) (:start . 158)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 172)\n  (:start . 166) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s214.7) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001922@unknown@formal@none@1@S@However, other X1 box-specific activities were detected in all these cell lines.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "x1") (:form . "X1") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "box-specific") (:form . "box-specific") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s214.8) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001923@unknown@formal@none@1@S@To determine whether these different X1 box activities represented distinct DNA binding proteins or multimeric forms of the same factor ( s ), protease treatment of the crude nuclear extracts followed by DNA-binding assays were carried out and demonstrated that B cell extracts contain at least two X1-specific factors.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "x1") (:form . "X1") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "VBD") (:stem . "represent") (:form . "represented") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multimeric") (:form . "multimeric") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . 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"DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "crude") (:form . "crude") (:end . 174)\n  (:start . 169) (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 191)\n  (:start . 183) (:id . 72))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 200)\n  (:start . 192) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 215)\n  (:start . 204) (:id . 75))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 222)\n  (:start . 216) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 227) (:start . 223)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 235)\n  (:start . 228) (:id . 78))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 239) (:start . 236)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 256)\n  (:start . 244) (:id . 81))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 261) (:start . 257)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 263) (:start . 262)\n  (:id . 83))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 268) (:start . 264)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 277)\n  (:start . 269) (:id . 85))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 285)\n  (:start . 278) (:id . 86))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 288) (:start . 286)\n  (:id . 87))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 294)\n  (:start . 289) (:id . 88))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 298) (:start . 295)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "x1-specific") (:form . "X1-specific") (:end . 310)\n  (:start . 299) (:id . 90))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 318)\n  (:start . 311) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 319) (:start . 318)\n  (:id . 92)))@@@1@51@((:hcues ((:id . :x214.9.1) (:span 97 99)) ((:id . :x214.9.2) (:span 13 20)))\n (:hscopes ((:id . :x214.9.1) (:span 67 141))\n  ((:id . :x214.9.2) (:span 13 141)))\n (:identifiers (:sid . :s214.9) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001924@unknown@formal@none@1@S@One of these cleaved products (band 1 pk) correlates with RFX activity.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "cleave") (:form . "cleaved") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pk") (:form . "pk") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 52)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s214.10) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001925@unknown@formal@none@1@S@A similar comparison with protease-treated extracts prepared from Jurkat cells demonstrated the presence of the band 1pk activity despite an absence of the native RFX activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "protease-treated") (:form . "protease-treated")\n  (:end . 42) (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 72)\n  (:start . 66) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 91)\n  (:start . 79) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "1pk") (:form . "1pk") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 137)\n  (:start . 130) (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 162)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "rfx") (:form . "RFX") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s214.11) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001926@unknown@formal@none@1@S@In contrast, protease treatment and analysis of SJO extracts showed no detectable levels of the band 1pk activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SJO") (:form . "SJO") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 67) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "1pk") (:form . "1pk") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x214.12.1) (:span 68 70)))\n (:nscopes ((:id . :x214.12.1) (:span 68 113)))\n (:identifiers (:sid . :s214.12) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001927@unknown@formal@none@1@S@These results demonstrate that multiple X1 box-specific DNA-binding activities exist in all lymphoid cells, but the presence of an actively binding RFX species correlates with class II transcription.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "x1") (:form . "X1") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "box-specific") (:form . "box-specific") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 67)\n  (:start . 56) (:id . 49))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 84) (:start . 79)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 175) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s214.13) (:did . :|93171603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001928@unknown@formal@none@1@S@Replication of type 1 human immunodeficiency viruses containing linker substitution mutations in the -201 to -130 region of the long terminal repeat.@(((:tag . "NNP") (:stem . "Replication") (:form . "Replication") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 44) (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "linker") (:form . "linker") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 83)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 93)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-201") (:form . "-201") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-130") (:form . "-130") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 120)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s215.1) (:did . :|93172387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001930@unknown@formal@none@1@S@In order to confirm the significance of this region in the context of viral replication, we constructed several of these LS mutations (-201 to -184, -183 to -166, -165 to -148, and -148 to -130) in proviruses and prepared viral stocks by cocultivation of transfected RD cells with CEMx174 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . 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5001931@unknown@formal@none@1@S@In addition, two mutations between -93 and -76 and between -75 and -58 were utilized, since they affect the nuclear factor kappa B (NF-kappa B)- and Sp1-binding sites and were expected to diminish viral replication.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "-93") (:form . "-93") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-76") (:form . "-76") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "CD") (:stem . "-75") (:form . "-75") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-58") (:form . "-58") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 103)\n  (:start . 97) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 122)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 68))\n ((:tag . "NNP") (:stem . "B)-") (:form . "B)-") (:end . 144) (:start . 141)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "sp1-binding") (:form . "Sp1-binding") (:end . 160)\n  (:start . 149) (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 175) (:start . 171)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 184)\n  (:start . 176) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 76))\n ((:tag . "VB") (:stem . "diminish") (:form . "diminish") (:end . 196)\n  (:start . 188) (:id . 77))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 202)\n  (:start . 197) (:id . 78))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 214)\n  (:start . 203) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x215.4.1) (:span 176 184)))\n (:hscopes ((:id . :x215.4.1) (:span 171 214)))\n (:identifiers (:sid . :s215.4) (:did . :|93172387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001932@unknown@formal@none@1@S@Our results suggest that while transfection analyses offer an adequate approximation of the effects of the LS mutations, the analysis of viral replication using a mutant viral stock presents a more accurate picture, which is sometimes at variance with the transfection results.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBP") (:stem . "offer") (:form . "offer") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adequate") (:form . "adequate") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "approximation") (:form . "approximation")\n  (:end . 84) (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LS") (:form . "LS") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 160) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 169)\n  (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "stock") (:form . "stock") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . "VBZ") (:stem . "present") (:form . "presents") (:end . 190)\n  (:start . 182) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 197) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 206)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "picture") (:form . "picture") (:end . 214)\n  (:start . 207) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 221)\n  (:start . 216) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 224) (:start . 222)\n  (:id . 78))\n ((:tag . "RB") (:stem . "sometimes") (:form . "sometimes") (:end . 234)\n  (:start . 225) (:id . 79))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 237) (:start . 235)\n  (:id . 80))\n ((:tag . "NN") (:stem . "variance") (:form . "variance") (:end . 246)\n  (:start . 238) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 251) (:start . 247)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 255) (:start . 252)\n  (:id . 83))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 268)\n  (:start . 256) (:id . 84))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 276)\n  (:start . 269) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x215.5.1) (:span 12 19)))\n (:hscopes ((:id . :x215.5.1) (:span 12 276)))\n (:identifiers (:sid . :s215.5) (:did . :|93172387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001933@unknown@formal@none@1@S@Three mutants (-201/-184 NXS, -165/-148 NXS, and -147/-130 NXS) had effects on viral replication that were much more severe than the effects predicted from their performance in transfection analyses, and the effects of two LS mutations (-201/-184 NXS and -183/-166 NXS) were not predicted by their effects in transfection.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "-201/-184") (:form . "-201/-184") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN|NNS") (:stem . "nxs") (:form . "NXS") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-165/-148") (:form . 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5001934@unknown@formal@none@1@S@In addition, we observed cell type-specific permissiveness to replication of some mutant viruses.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "permissiveness") (:form . "permissiveness")\n  (:end . 58) (:start . 44) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s215.7) (:did . :|93172387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001935@unknown@formal@none@1@S@In the cell types tested, the LS mutations indicated an apparent requirement not only for the intact NF-kappa B and SP1-binding sites but also for several regions between -201 and -130 not previously associated with viral infectivity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 24) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LS") (:form . "LS") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sp1-binding") (:form . "SP1-binding") (:end . 127)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 170)\n  (:start . 163) (:id . 70))\n ((:tag . "CD") (:stem . "-201") (:form . "-201") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "CD") (:stem . "-130") (:form . "-130") (:end . 184) (:start . 180)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 199)\n  (:start . 189) (:id . 75))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 210)\n  (:start . 200) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 221)\n  (:start . 216) (:id . 78))\n ((:tag . "NN") (:stem . "infectivity") (:form . "infectivity") (:end . 233)\n  (:start . 222) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x215.8.2) (:span 43 52)))\n (:ncues ((:id . :x215.8.1) (:span 185 188)))\n (:hscopes ((:id . :x215.8.2) (:span 43 233)))\n (:nscopes ((:id . :x215.8.1) (:span 185 233)))\n (:identifiers (:sid . :s215.8) (:did . :|93172387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001936@unknown@formal@none@1@S@Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).@(((:tag . "NN") (:stem . "dimerization") (:form . "Dimerization") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nf-kb2") (:form . "NF-KB2") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 76) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "I") (:form . "I") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "MAD-3") (:form . "MAD-3") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s216.1) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001937@unknown@formal@none@1@S@Inducible expression of human immunodeficiency virus (HIV) is regulated by a cellular transcription factor, nuclear factor kappa B (NF-kappa B).@(((:tag . "JJ") (:stem . "inducible") (:form . "Inducible") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 46) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 99) (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s216.2) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001938@unknown@formal@none@1@S@NF-kappa B is composed of distinct subunits; five independent genes, NFKB1(p105), NFKB2(p100), RelA(p65), c-rel and relB, that encode related proteins that bind to kappa B DNA elements have been isolated.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFKB1(p105)") (:form . "NFKB1(p105)") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFKB2(p100)") (:form . "NFKB2(p100)") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "relB") (:form . "relB") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 133)\n  (:start . 127) (:id . 65))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 169)\n  (:start . 164) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 175) (:start . 172)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 184)\n  (:start . 176) (:id . 74))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 194) (:start . 190)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 203)\n  (:start . 195) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s216.3) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001940@unknown@formal@none@1@S@Here we examine the biochemical basis for the transcriptional regulation of HIV by NFKB2.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "examine") (:form . "examine") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 61) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nfkb2") (:form . "NFKB2") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s216.5) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001941@unknown@formal@none@1@S@Using Scatchard analysis, we have determined the dissociation constants of homodimeric p49 and heterodimeric p49/p65 for binding to the HIV kappa B site.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Scatchard") (:form . "Scatchard") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "constant") (:form . "constants") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "homodimeric") (:form . "homodimeric") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "p49") (:form . "p49") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "p49/p65") (:form . "p49/p65") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s216.6) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001942@unknown@formal@none@1@S@p49 has a approximately 18-fold-lower affinity for the HIV kappa B site (KD = 69.1 pM) than does the approximately 50-kDa protein NFKB1(p50) derived from p105 (KD = 3.9 pM).@(((:tag . "NN") (:stem . "p49") (:form . "p49") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "18-fold-lower") (:form . "18-fold-lower")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kd") (:form . "KD") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "CD") (:stem . "69.1") (:form . "69.1") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pm") (:form . "pM") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 114) (:start . 101) (:id . 63))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 121)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "NNS") (:stem . "NFKB1(p50)") (:form . "NFKB1(p50)") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 148)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kd") (:form . "KD") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 164) (:start . 163)\n  (:id . 72))\n ((:tag . "CD") (:stem . "3.9") (:form . "3.9") (:end . 168) (:start . 165)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "pM") (:form . "pM") (:end . 171) (:start . 169)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s216.7) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001943@unknown@formal@none@1@S@In contrast, the affinity of heterodimeric NFKB2(p49)/RelA(p65) for this site is approximately 6-fold higher (KD = 11.8 pM) than that of p49 alone.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 42) (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "NFKB2(p49)/RelA(p65)")\n  (:form . "NFKB2(p49)/RelA(p65)") (:end . 63) (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 94) (:start . 81) (:id . 54))\n ((:tag . "RB") (:stem . "6-fold") (:form . "6-fold") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kd") (:form . "KD") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "CD") (:stem . "11.8") (:form . "11.8") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pm") (:form . "pM") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p49") (:form . "p49") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s216.8) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001944@unknown@formal@none@1@S@Consistent with these findings, in vitro transcription was stimulated 18-fold by the addition of preformed, heterodimeric NFKB2(p49)/RelA(p65) protein.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "RB") (:stem . "18-fold") (:form . "18-fold") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "preformed") (:form . "preformed") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "NFKB2(p49)/RelA(p65)")\n  (:form . "NFKB2(p49)/RelA(p65)") (:end . 142) (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 150)\n  (:start . 143) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s216.9) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001945@unknown@formal@none@1@S@Transcriptional activation of the HIV enhancer was also subject to regulation by recently cloned I kappa B-alpha(MAD-3).@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "subject") (:form . "subject") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "B-alpha(MAD-3)") (:form . "B-alpha(MAD-3)")\n  (:end . 119) (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s216.10) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001946@unknown@formal@none@1@S@Recombinant I kappa B-alpha(MAD-3) inhibited the DNA binding activity of p65, p49/p65, and p50/p65 but stimulated the binding of NFKB2(p49) or NFKB1(p50).@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "B-alpha(MAD-3)") (:form . "B-alpha(MAD-3)")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p49/p65") (:form . "p49/p65") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NFKB2(p49)") (:form . "NFKB2(p49)") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NFKB1(p50)") (:form . "NFKB1(p50)") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x216.11.1) (:span 140 142)))\n (:hscopes ((:id . :x216.11.1) (:span 129 153)))\n (:identifiers (:sid . :s216.11) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001947@unknown@formal@none@1@S@Functional activation of an HIV reporter plasmid by p49/p65 in transiently transfected Jurkat T-leukemia cells was also inhibited by coexpression of MAD-3.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p49/p65") (:form . "p49/p65") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "NNP") (:stem . "T-leukemia") (:form . "T-leukemia") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 145)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MAD-3") (:form . "MAD-3") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s216.12) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001948@unknown@formal@none@1@S@(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "abstract") (:form . "ABSTRACT") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s216.13) (:did . :|93180775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001950@unknown@formal@none@1@S@In these studies, we have identified DNA sequences and specific protein interactions necessary for transcriptional regulation of the human prointerleukin 1 beta (proIL-1 beta) gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 114) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "prointerleukin") (:form . "prointerleukin")\n  (:end . 153) (:start . 139) (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 155) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "proil-1") (:form . "proIL-1") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s217.2) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001951@unknown@formal@none@1@S@A cell-type-independent lipopolysaccharide ( LPS ) -responsive enhancer element located between -3757 and -2729 bp upstream from the transcription start site (cap site) consisted of at least six discrete subregions which were essential to the maximal induction by LPS in transfected monocytes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cell-type-independent")\n  (:form . "cell-type-independent") (:end . 23) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 42) (:start . 24) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 48) (:start . 45)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "-responsive") (:form . "-responsive") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 71)\n  (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 79)\n  (:start . 72) (:id . 50))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 95)\n  (:start . 88) (:id . 52))\n ((:tag . "CD") (:stem . "-3757") (:form . "-3757") (:end . 101) (:start . 96)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-2729") (:form . "-2729") (:end . 111)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 146) (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cap") (:form . "cap") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 190)\n  (:start . 185) (:id . 70))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "discrete") (:form . "discrete") (:end . 203)\n  (:start . 195) (:id . 72))\n ((:tag . "NNS") (:stem . "subregion") (:form . "subregions") (:end . 214)\n  (:start . 204) (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 220)\n  (:start . 215) (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 225) (:start . 221)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 235)\n  (:start . 226) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 238) (:start . 236)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 242) (:start . 239)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 250)\n  (:start . 243) (:id . 79))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 260)\n  (:start . 251) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 263) (:start . 261)\n  (:id . 81))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 267) (:start . 264)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 270) (:start . 268)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 282)\n  (:start . 271) (:id . 84))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 292)\n  (:start . 283) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s217.3) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001952@unknown@formal@none@1@S@The enhancer also appeared to mediate phorbol myristate acetate induction in monocytes and IL-1 responsiveness in fibroblasts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 110) (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x217.4.1) (:span 18 26)))\n (:hscopes ((:id . :x217.4.1) (:span 0 125)))\n (:identifiers (:sid . :s217.4) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001953@unknown@formal@none@1@S@Deletion and base substitution mutations along with DNA binding studies demonstrated that the enhancer contained a minimum of three functional protein binding sequences, two of which appeared to be important for gene induction.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 84)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "minimum") (:form . "minimum") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 150)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 168)\n  (:start . 159) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 182)\n  (:start . 177) (:id . 68))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 207)\n  (:start . 198) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 211) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 216) (:start . 212)\n  (:id . 74))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 226)\n  (:start . 217) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x217.5.1) (:span 183 191)))\n (:hscopes ((:id . :x217.5.1) (:span 170 226)))\n (:identifiers (:sid . :s217.5) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001954@unknown@formal@none@1@S@One of the essential proteins which bound to the enhancer was similar or identical to members of the C/EBP family of transcription factors required for both IL-1- and LPS-specific induction of the IL-6 gene (i.e., the NF-IL6 proteins).@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-1-") (:form . "IL-1-") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "lps-specific") (:form . "LPS-specific") (:end . 179)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 189)\n  (:start . 180) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 201) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 206) (:start . 202)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 76))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 212) (:start . 208)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 224)\n  (:start . 218) (:id . 80))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 233)\n  (:start . 225) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x217.6.1) (:span 70 72)))\n (:hscopes ((:id . :x217.6.1) (:span 62 82)))\n (:identifiers (:sid . :s217.6) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001955@unknown@formal@none@1@S@When ligated to the proIL-1 beta cap site-proximal region (located between -131 to +12), both the proIL-1 beta and the simian virus 40 enhancer elements functioned more efficiently in monocytes than in HeLa cells, which are not normally competent for IL-1 beta expression.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "ligate") (:form . "ligated") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "proil-1") (:form . "proIL-1") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cap") (:form . "cap") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . 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5001956@unknown@formal@none@1@S@When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "ligate") (:form . "ligated") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proil-1") (:form . "proIL-1") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "JJ") (:stem . "acetate-stimulated") (:form . "acetate-stimulated")\n  (:end . 131) (:start . 113) (:id . 61))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "proil-1") (:form . "proIL-1") (:end . 181)\n  (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "promoter-proximal") (:form . "promoter-proximal")\n  (:end . 204) (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 216)\n  (:start . 205) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 220) (:start . 217)\n  (:id . 74))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 227)\n  (:start . 221) (:id . 75))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 239)\n  (:start . 228) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x217.8.1) (:span 144 154)))\n (:hscopes ((:id . :x217.8.1) (:span 144 239)))\n (:identifiers (:sid . :s217.8) (:did . :|93180777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001957@unknown@formal@none@1@S@Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PILOT") (:form . "PILOT") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x218.1.1) (:span 23 31)))\n (:hscopes ((:id . :x218.1.1) (:span 23 52)))\n (:identifiers (:sid . :s218.1) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001958@unknown@formal@none@1@S@Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).@(((:tag . "JJ") (:stem . "few") (:form . "Few") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . 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5001960@unknown@formal@none@1@S@Induction of the PILOT gene is detectable in human T cells 20 min following activation in the presence of cycloheximide and is fully suppressed by CyA.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PILOT") (:form . "PILOT") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 119) (:start . 106) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s218.4) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001961@unknown@formal@none@1@S@The PILOT protein has a calculated M(r) of 42.6 kDa and contains three zinc fingers of the C2H2-type at the carboxyl-terminus which are highly homologous to the zinc finger regions of the transcription factors EGR1, EGR2, and pAT 133.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pilot") (:form . "PILOT") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "M(r)") (:form . "M(r)") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "42.6") (:form . "42.6") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c2h2-type") (:form . "C2H2-type") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "carboxyl-terminus") (:form . "carboxyl-terminus")\n  (:end . 125) (:start . 108) (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 172)\n  (:start . 166) (:id . 70))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 201) (:start . 188) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 209)\n  (:start . 202) (:id . 75))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "EGR2") (:form . "EGR2") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 80))\n ((:tag . "NN") (:stem . "pat") (:form . "pAT") (:end . 229) (:start . 226)\n  (:id . 81))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 233) (:start . 230)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s218.5) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001962@unknown@formal@none@1@S@In contrast to T cells, in fibroblasts PILOT gene expression requires only one signal (PMA) and is not affected by CyA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 38)\n  (:start . 27) (:id . 49))\n ((:tag . "NNP") (:stem . "PILOT") (:form . "PILOT") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 111)\n  (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x218.6.1) (:span 99 102)))\n (:nscopes ((:id . :x218.6.1) (:span 96 118)))\n (:identifiers (:sid . :s218.6) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001963@unknown@formal@none@1@S@This observation directly demonstrates the existence of a Ca2+ signal-dependent regulatory element obligatory for expression of some genes in T cells but not in fibroblasts.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "signal-dependent") (:form . "signal-dependent")\n  (:end . 79) (:start . 63) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 109)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 57))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 132) (:start . 128)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 138)\n  (:start . 133) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 172)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x218.7.1) (:span 154 157)))\n (:nscopes ((:id . :x218.7.1) (:span 154 172)))\n (:identifiers (:sid . :s218.7) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001964@unknown@formal@none@1@S@This differential expression model will be valuable in the dissection of the dual signal pathway in T cells and the effects of CyA upon it.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "valuable") (:form . "valuable") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dissection") (:form . "dissection") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s218.8) (:did . :|93183827|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001965@unknown@formal@none@1@S@Human CD4 lymphocytes specifically recognize a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CD4") (:form . "CD4") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 67)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "NNP") (:stem . "pml/RAR") (:form . "pml/RAR") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 129)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 138)\n  (:start . 133) (:id . 61))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 152) (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 161)\n  (:start . 153) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s219.1) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001966@unknown@formal@none@1@S@Fusion proteins present in leukemic cells frequently contain a new amino acid at the fusion point.@(((:tag . "NN") (:stem . "fusion") (:form . "Fusion") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s219.2) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001967@unknown@formal@none@1@S@We tested whether a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells, can be recognized by human T lymphocytes in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bcr1/25") (:form . "BCR1/25") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 50)\n  (:start . 38) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NNP") (:stem . "pml/RAR") (:form . "pml/RAR") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 127)\n  (:start . 116) (:id . 63))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 137)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 160) (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 73))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 200)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 209)\n  (:start . 204) (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 211) (:start . 210)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 223)\n  (:start . 212) (:id . 80))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 81))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 232)\n  (:start . 227) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x219.3.1) (:span 183 186))\n  ((:id . :x219.3.2) (:span 10 17)))\n (:hscopes ((:id . :x219.3.1) (:span 18 232))\n  ((:id . :x219.3.2) (:span 10 232)))\n (:identifiers (:sid . :s219.3) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001968@unknown@formal@none@1@S@CD4+ lymphocytes, at both polyclonal and clonal level, recognized peptide BCR1/25 in an HLA-DR--restricted fashion on presentation by autologous antigen-presenting cell (APC) or by APC expressing the HLA-DR11 restricting molecule.@(((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "recognize") (:form . "recognized") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "bcr1/25") (:form . "BCR1/25") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "HLA-DR–restricted") (:form . "HLA-DR–restricted")\n  (:end . 106) (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 130)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "autologous") (:form . "autologous") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 163) (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 168) (:start . 164)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 195)\n  (:start . 185) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "hla-dr11") (:form . "HLA-DR11") (:end . 208)\n  (:start . 200) (:id . 73))\n ((:tag . "VBG") (:stem . "restrict") (:form . "restricting") (:end . 220)\n  (:start . 209) (:id . 74))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 229)\n  (:start . 221) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s219.4) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001970@unknown@formal@none@1@S@One clone (DEG5) also exerted a high and specific cytotoxicity against autologous cells pulsed with BCR1/25.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deg5") (:form . "DEG5") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "exert") (:form . "exerted") (:end . 29)\n  (:start . 22) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 36) (:start . 32)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 49)\n  (:start . 41) (:id . 52))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 62)\n  (:start . 50) (:id . 53))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "JJ") (:stem . "autologous") (:form . "autologous") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "pulse") (:form . "pulsed") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bcr1/25") (:form . "BCR1/25") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s219.6) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001971@unknown@formal@none@1@S@The autologous DE LCL containing a transduced pml/RAR alpha fusion gene and expressing a bcr1 type of the pml/RAR alpha hybrid protein induced the proliferation of DE anti-BCR1/25 T cell clones.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "autologous") (:form . "autologous") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "DE") (:form . "DE") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCL") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "pml/RAR") (:form . "pml/RAR") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bcr1") (:form . "bcr1") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "pml/RAR") (:form . "pml/RAR") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 160) (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DE") (:form . "DE") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "anti-bcr1/25") (:form . "anti-BCR1/25") (:end . 179)\n  (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 193)\n  (:start . 187) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s219.7) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001972@unknown@formal@none@1@S@It is concluded that the bcr1 type-pml/RAR alpha fusion protein of APL contains an antigenic site, absent from the normal parent molecules and recognized by human CD4+ lymphocytes.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcr1") (:form . "bcr1") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "type-pml/RAR") (:form . "type-pml/RAR") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "parent") (:form . "parent") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 179)\n  (:start . 168) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s219.8) (:did . :|93184333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001973@unknown@formal@none@1@S@A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "thrombospondin") (:form . "thrombospondin")\n  (:end . 107) (:start . 93) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s220.1) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001974@unknown@formal@none@1@S@The expression of thrombospondin 1 (TSP 1), a member of the TSP gene family, is rapidly induced by growth factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "thrombospondin") (:form . "thrombospondin")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 75)\n  (:start . 69) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 60))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 87)\n  (:start . 80) (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 95)\n  (:start . 88) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 105)\n  (:start . 99) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 113)\n  (:start . 106) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s220.2) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001975@unknown@formal@none@1@S@We tested the ability of human TSP 1-chloramphenicol acetyltransferase constructs to respond to serum in stably transfected NIH-3T3 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "1-chloramphenicol") (:form . "1-chloramphenicol")\n  (:end . 52) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 70) (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 123)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "nih-3t3") (:form . "NIH-3T3") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s220.3) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001976@unknown@formal@none@1@S@Two transcriptional elements in the TSP 1 promoter, a distal element at -1280 and a proximal element at -65, were required for the response of the human TSP 1 gene to serum.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-1280") (:form . "-1280") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-65") (:form . "-65") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 139)\n  (:start . 131) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 152)\n  (:start . 147) (:id . 70))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 156) (:start . 153)\n  (:id . 71))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 158) (:start . 157)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 74))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 172)\n  (:start . 167) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s220.4) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001977@unknown@formal@none@1@S@The distal element contains the 5'-CC(A+T)6GG-3' consensus sequence characteristic of a serum-response element (SRE).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "5'-CC(A+T)6GG-3") (:form . "5'-CC(A+T)6GG-3")\n  (:end . 47) (:start . 32) (:id . 47))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 82) (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "serum-response") (:form . "serum-response")\n  (:end . 102) (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s220.5) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001978@unknown@formal@none@1@S@Deletions or mutations in this element reduced the serum response of the TSP 1 gene by 80-90%.@(((:tag . "NNS") (:stem . "deletion") (:form . "Deletions") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "CD") (:stem . "80-90") (:form . "80-90") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s220.6) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001980@unknown@formal@none@1@S@The proximal element contains the sequence 5'-GGCCAATGGG-3', which closely resembles the consensus binding motif for the CCAAT-binding factor NF-Y (CBF, CP1, alpha CP1).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "5'-ggccaatggg-3") (:form . "5'-GGCCAATGGG-3")\n  (:end . 58) (:start . 43) (:id . 48))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "VBZ") (:stem . "resemble") (:form . "resembles") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ccaat-binding") (:form . "CCAAT-binding")\n  (:end . 134) (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CP1") (:form . "CP1") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "cp1") (:form . "CP1") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s220.8) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001981@unknown@formal@none@1@S@Deletions or mutations in this element also reduced the serum response by 80-90%.@(((:tag . "NNS") (:stem . "deletion") (:form . "Deletions") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "80-90") (:form . "80-90") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s220.9) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001982@unknown@formal@none@1@S@Methylation interference analysis of the -65 region identified a pattern of contacts with nuclear factors resembling that for NF-Y, and an NF-Y-binding site and the proximal TSP 1 element cross-competed in gel-shift assays, whereas their binding mutants did not.@(((:tag . "NNP") (:stem . "Methylation") (:form . "Methylation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 33)\n  (:start . 25) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-65") (:form . "-65") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "contact") (:form . "contacts") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nf-y-binding") (:form . "NF-Y-binding") (:end . 151)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "VBD") (:stem . "cross-compete") (:form . "cross-competed")\n  (:end . 202) (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 215)\n  (:start . 206) (:id . 74))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 222)\n  (:start . 216) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 76))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 231)\n  (:start . 224) (:id . 77))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 237)\n  (:start . 232) (:id . 78))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 245)\n  (:start . 238) (:id . 79))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 253)\n  (:start . 246) (:id . 80))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 257) (:start . 254)\n  (:id . 81))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 261) (:start . 258)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x220.10.1) (:span 258 261)))\n (:nscopes ((:id . :x220.10.1) (:span 258 261)))\n (:identifiers (:sid . :s220.10) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001983@unknown@formal@none@1@S@Finally, an abbreviated TSP 1 promoter/5'-flank, containing the SRE- and NF-Y-binding sites, mediated a serum response that was close in magnitude to that of the parent promoter.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "abbreviate") (:form . "abbreviated") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter/5'-flank") (:form . "promoter/5'-flank")\n  (:end . 47) (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sre-") (:form . "SRE-") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nf-y-binding") (:form . "NF-Y-binding") (:end . 85)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "parent") (:form . "parent") (:end . 168)\n  (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s220.11) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001984@unknown@formal@none@1@S@We conclude that the serum response of the human TSP 1 gene requires the coordinated function of an SRE- and NF-Y-binding site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 84)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sre-") (:form . "SRE-") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nf-y-binding") (:form . "NF-Y-binding") (:end . 121)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s220.12) (:did . :|93186809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001985@unknown@formal@none@1@S@Suppression of a cellular differentiation program by phorbol esters coincides with inhibition of binding of a cell-specific transcription factor (NF-E2) to an enhancer element required for expression of an erythroid-specific gene.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "VBZ") (:stem . "coincide") (:form . "coincides") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 144)\n  (:start . 138) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 175)\n  (:start . 168) (:id . 67))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 184)\n  (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 188) (:start . 185)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 205) (:start . 203)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 224) (:start . 206) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 229) (:start . 225)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s221.1) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001986@unknown@formal@none@1@S@Induction by hemin increases, while induction with 12-O-tetradecanoylphorbol-13-acetate (TPA) represses, erythroid-specific gene expression in the human cell line K562.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 87) (:start . 51)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 103)\n  (:start . 94) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 123) (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 162) (:start . 158)\n  (:id . 63))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 167) (:start . 163)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s221.2) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001987@unknown@formal@none@1@S@We analyzed the effects of hemin or TPA induction on the binding and activity of transcription factors at a regulatory element found within the transcriptional regulatory sequences of many erythroid-specific genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 118)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 159) (:start . 144) (:id . 66))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 170)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 207) (:start . 189) (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 213)\n  (:start . 208) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s221.3) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001988@unknown@formal@none@1@S@TPA induction increases the binding of ubiquitous AP-1 factors to this element.@(((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s221.4) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001990@unknown@formal@none@1@S@Hemin induction of K562 cells does not facilitate the binding of NF-E2 to its recognition site.@(((:tag . "NNP") (:stem . "Hemin") (:form . "Hemin") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x221.6.1) (:span 35 38)))\n (:nscopes ((:id . :x221.6.1) (:span 35 94)))\n (:identifiers (:sid . :s221.6) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001991@unknown@formal@none@1@S@Hemin induction appears to nonspecifically increase the expression of transiently transfected genes in K562 cells.@(((:tag . "NNP") (:stem . "Hemin") (:form . "Hemin") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "RB") (:stem . "nonspecifically") (:form . "nonspecifically")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 81)\n  (:start . 70) (:id . 51))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x221.7.1) (:span 16 23)))\n (:hscopes ((:id . :x221.7.1) (:span 0 113)))\n (:identifiers (:sid . :s221.7) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001992@unknown@formal@none@1@S@Beyond this nonspecific increase in gene expression, hemin induction acts to increase the activity of the lineage limited transcription factor NF-E2.@(((:tag . "IN") (:stem . "beyond") (:form . "Beyond") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nonspecific") (:form . "nonspecific") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 148)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s221.8) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001993@unknown@formal@none@1@S@The divergent effects of hemin and TPA on gene expression in K562 cells are mediated, in part, by their contrasting effects on the transcription factor NF-E2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 103)\n  (:start . 98) (:id . 62))\n ((:tag . "VBG") (:stem . "contrast") (:form . "contrasting") (:end . 115)\n  (:start . 104) (:id . 63))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 157)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s221.9) (:did . :|93186822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001994@unknown@formal@none@1@S@The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd28-responsive") (:form . "CD28-responsive")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s222.1) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5001995@unknown@formal@none@1@S@Optimal activation of T cells requires at least two signals.@(((:tag . "JJ") (:stem . "optimal") (:form . "Optimal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s222.2) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001996@unknown@formal@none@1@S@One signal can be delivered by the antigen-specific T-cell receptor, and the second signal is provided by the costimulatory molecule ( s ) delivered by the antigen-presenting cell.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "deliver") (:form . "delivered") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "antigen-specific") (:form . "antigen-specific")\n  (:end . 51) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 123) (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "deliver") (:form . "delivered") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 174) (:start . 156) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s222.3) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001997@unknown@formal@none@1@S@CD28 is a T-cell surface molecule and stimulation through this protein plays an important role in delivering the second activation signal.@(((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "deliver") (:form . "delivering") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s222.4) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5001998@unknown@formal@none@1@S@In this report, we show that in human peripheral blood T cells, CD28-mediated signal transduction involves the rel family proteins--c-Rel, p50, and p65.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 48)\n  (:start . 38) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd28-mediated") (:form . "CD28-mediated")\n  (:end . 77) (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 97)\n  (:start . 85) (:id . 58))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "proteins–c-Rel") (:form . "proteins–c-Rel")\n  (:end . 137) (:start . 122) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s222.5) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002000@unknown@formal@none@1@S@It is also shown in this report that , in response to PMA/anti-CD28 mAb or anti-CD3/anti-CD28 mAb, c-Rel, p50, and p65 are associated with CD28-responsive element present in the promoter of the human interleukin 2 gene.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pma/anti-cd28") (:form . "PMA/anti-CD28")\n  (:end . 67) (:start . 54) (:id . 54))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-cd3/anti-cd28") (:form . "anti-CD3/anti-CD28")\n  (:end . 93) (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 133)\n  (:start . 123) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cd28-responsive") (:form . "CD28-responsive")\n  (:end . 154) (:start . 139) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 162)\n  (:start . 155) (:id . 70))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 170)\n  (:start . 163) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 186)\n  (:start . 178) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 199)\n  (:start . 194) (:id . 77))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 211)\n  (:start . 200) (:id . 78))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 213) (:start . 212)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 218) (:start . 214)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s222.7) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002001@unknown@formal@none@1@S@The functional significance of c-Rel involvement in the CD28-responsive complex is demonstrated by transient transfection analysis, where cotransfection of c-Rel augments the level of expression of a chloramphenicol acetyltransferase reporter gene linked to the CD28-responsive element.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd28-responsive") (:form . "CD28-responsive")\n  (:end . 71) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 121)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 130)\n  (:start . 122) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 58))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 137)\n  (:start . 132) (:id . 59))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 152) (:start . 138) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 161)\n  (:start . 156) (:id . 62))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 170)\n  (:start . 162) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 64))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 180)\n  (:start . 175) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 194)\n  (:start . 184) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 69))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 215) (:start . 200) (:id . 70))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 233) (:start . 216) (:id . 71))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 242)\n  (:start . 234) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 247) (:start . 243)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 254)\n  (:start . 248) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 257) (:start . 255)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 261) (:start . 258)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "cd28-responsive") (:form . "CD28-responsive")\n  (:end . 277) (:start . 262) (:id . 77))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 285)\n  (:start . 278) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s222.8) (:did . :|93189564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002002@unknown@formal@none@1@S@Expression of the Tat protein of HIV1 in human promonocytic U937 cells.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 59)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s223.1) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002003@unknown@formal@none@1@S@Numerous studies have shown that , upon HIV1 infection, human promonocytic U937 cells were induced to differentiate , as indicated, for example, by increased expression of adhesion molecules.@(((:tag . "JJ") (:stem . "numerous") (:form . "Numerous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 157)\n  (:start . 148) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 180)\n  (:start . 172) (:id . 71))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 190)\n  (:start . 181) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s223.2) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002004@unknown@formal@none@1@S@One of the viral proteins involved in this process might be the Tat protein.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x223.3.1) (:span 51 56)))\n (:hscopes ((:id . :x223.3.1) (:span 51 75)))\n (:identifiers (:sid . :s223.3) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002005@unknown@formal@none@1@S@Indeed, this viral protein, which is essential for productive infection, has also been shown to display growth-stimulating properties and immunomodulatory activities.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VB") (:stem . "display") (:form . "display") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "JJ") (:stem . "growth-stimulating") (:form . "growth-stimulating")\n  (:end . 122) (:start . 104) (:id . 61))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 154) (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 165)\n  (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s223.4) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002006@unknown@formal@none@1@S@In order to apprehend the role of the HIV1 tat gene in inducing the differentiation of HIV1-infected U937 cells, we have successfully introduced this gene into U937 cells by infecting them with retroviral particles transducing tat.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "apprehend") (:form . "apprehend") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hiv1") (:form . "HIV1") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 83) (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hiv1-infected") (:form . "HIV1-infected")\n  (:end . 100) (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 133)\n  (:start . 121) (:id . 64))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "infect") (:form . "infecting") (:end . 183)\n  (:start . 174) (:id . 72))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 188) (:start . 184)\n  (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 204)\n  (:start . 194) (:id . 75))\n ((:tag . "NNS") (:stem . "particle") (:form . "particles") (:end . 214)\n  (:start . 205) (:id . 76))\n ((:tag . "VBG") (:stem . "transduce") (:form . "transducing") (:end . 226)\n  (:start . 215) (:id . 77))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 230) (:start . 227)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s223.5) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002007@unknown@formal@none@1@S@The effect of the Tat protein constitutively expressed by these cells upon their differentiation was then evaluated by looking for the expression of the c-fos and of the c-fms proto-oncogenes which are linked to the differentiation of myelomonoblastic cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 80)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 96) (:start . 81) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "look") (:form . "looking") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-fms") (:form . "c-fms") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 191) (:start . 176) (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 208)\n  (:start . 202) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 231) (:start . 216) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "myelomonoblastic") (:form . "myelomonoblastic")\n  (:end . 251) (:start . 235) (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 257)\n  (:start . 252) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s223.6) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002008@unknown@formal@none@1@S@Northern blot analysis revealed in these cells, an increase in the transcription of these two proto-oncogenes, and this increase was amplified after treatment with phorbol myristate acetate.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 109) (:start . 94) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 189)\n  (:start . 182) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s223.7) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002010@unknown@formal@none@1@S@These results indicate that , among HIV1 gene products, the Tat protein appears to trigger monocytic differentiation, and suggests that this viral protein directs progenitors of the monocyte/macrophage lineage towards a differentiation stage in which production of viral antigens and virions might be more efficient.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hiv1") (:form . 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"which") (:end . 250)\n  (:start . 245) (:id . 78))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 261)\n  (:start . 251) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 264) (:start . 262)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 270)\n  (:start . 265) (:id . 81))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 279)\n  (:start . 271) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 283) (:start . 280)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "virion") (:form . "virions") (:end . 291)\n  (:start . 284) (:id . 84))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 297)\n  (:start . 292) (:id . 85))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 300) (:start . 298)\n  (:id . 86))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 305) (:start . 301)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 315)\n  (:start . 306) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x223.9.1) (:span 292 297))\n  ((:id . :x223.9.2) (:span 122 130)) ((:id . :x223.9.3) (:span 72 79))\n  ((:id . :x223.9.4) (:span 14 27)))\n (:hscopes ((:id . :x223.9.1) (:span 292 315))\n  ((:id . :x223.9.2) (:span 122 315)) ((:id . :x223.9.3) (:span 56 116))\n  ((:id . :x223.9.4) (:span 14 315)))\n (:identifiers (:sid . :s223.9) (:did . :|93189882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002011@unknown@formal@none@1@S@Transcriptional regulation of the pyruvate kinase erythroid-specific promoter.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pyruvate") (:form . "pyruvate") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 68) (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 77)\n  (:start . 69) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s224.1) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002012@unknown@formal@none@1@S@Mammal pyruvate kinases are encoded by two genes.@(((:tag . "JJ") (:stem . "mammal") (:form . "Mammal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pyruvate") (:form . "pyruvate") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s224.2) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002013@unknown@formal@none@1@S@The L gene produces the erythroid (R-PK) or the hepatic (L-PK) isozymes by the alternative use of two promoters.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "R-PK") (:form . "R-PK") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 55)\n  (:start . 48) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "L-PK") (:form . "L-PK") (:end . 61) (:start . 57)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "isozyme") (:form . "isozymes") (:end . 71)\n  (:start . 63) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 90)\n  (:start . 79) (:id . 60))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 101) (:start . 98)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 111)\n  (:start . 102) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s224.3) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002014@unknown@formal@none@1@S@We report the characterization of the cis- and trans-acting elements involved in the tissue-specific activity of the L gene erythroid promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 30) (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cis-") (:form . "cis-") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "trans-acting") (:form . "trans-acting") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 100) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 133)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 142)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s224.4) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002015@unknown@formal@none@1@S@A R-PK DNA fragment extending from -870 to +54 relative to the cap site confers erythroid specificity to a reporter gene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "R-PK") (:form . "R-PK") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-870") (:form . "-870") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "+54") (:form . "+54") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cap") (:form . "cap") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s224.5) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002016@unknown@formal@none@1@S@Within this region, we define a minimal promoter (-62 to +54) that displays erythroid-specific activity and contains two DNA binding sites.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-62") (:form . "-62") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "CD") (:stem . "+54") (:form . "+54") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 75)\n  (:start . 67) (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 94) (:start . 76) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s224.6) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002017@unknown@formal@none@1@S@One, located at -50, binds members of the CCACC/Sp1 family and the other, located at -20, binds the erythroid factor GATA-1.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 12)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-50") (:form . "-50") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 26) (:start . 21)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ccacc/sp1") (:form . "CCACC/Sp1") (:end . 51)\n  (:start . 42) (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 81)\n  (:start . 74) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "CD") (:stem . "-20") (:form . "-20") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 95) (:start . 90)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 109)\n  (:start . 100) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 65))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 123)\n  (:start . 117) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s224.7) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002018@unknown@formal@none@1@S@Although the -20 GATA binding site (AGATAA) is also a potential TFIID binding site, it does not bind TFIID.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "-20") (:form . "-20") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AGATAA") (:form . "AGATAA") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 63)\n  (:start . 54) (:id . 54))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 100) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tfiid") (:form . "TFIID") (:end . 106)\n  (:start . 101) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x224.8.1) (:span 92 95)))\n (:nscopes ((:id . :x224.8.1) (:span 92 106)))\n (:identifiers (:sid . :s224.8) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002020@unknown@formal@none@1@S@Mutations and deletions of both sites indicate that only the association of CCACC/Sp1 and GATA binding sites can drive efficient and tissue-specific expression of this R-PK minimal promoter.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CCACC/Sp1") (:form . "CCACC/Sp1") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 148) (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 167) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "R-PK") (:form . "R-PK") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 180)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 189)\n  (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x224.10.1) (:span 38 51)))\n (:hscopes ((:id . :x224.10.1) (:span 38 189)))\n (:identifiers (:sid . :s224.10) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002021@unknown@formal@none@1@S@Finally, by co-transfection experiments, we study the elements involved in the hGATA-1 transactivation of the R-PK promoter in HeLa cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "co-transfection") (:form . "co-transfection")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "study") (:form . "study") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hgata-1") (:form . "hGATA-1") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 102) (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "R-PK") (:form . "R-PK") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s224.11) (:did . :|93194832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002022@unknown@formal@none@1@S@Stimulation of interleukin-1 alpha and interleukin-1 beta production in human monocytes by protein phosphatase 1 and 2A inhibitors.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 110)\n  (:start . 99) (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s225.1) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002023@unknown@formal@none@1@S@Protein phosphatases 1 and 2A are important in regulating cellular functions by controlling the phosphorylation state of their substrates.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 111) (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s225.2) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002024@unknown@formal@none@1@S@In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 56)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "calyculin") (:form . "calyculin") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 132)\n  (:start . 120) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 173) (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 196) (:start . 183) (:id . 72))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s225.3) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002025@unknown@formal@none@1@S@The increased mRNA accumulation was found to be primarily because of the increase in the transcription rate of the interleukin-1 genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s225.4) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002026@unknown@formal@none@1@S@Stimulation of interleukin-1 gene transcription may be caused by the stimulation of transcription factor activities, including those of AP-1, by these protein phosphatase inhibitors.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 132)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 170)\n  (:start . 159) (:id . 66))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 181)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x225.5.1) (:span 48 51)))\n (:hscopes ((:id . :x225.5.1) (:span 0 181)))\n (:identifiers (:sid . :s225.5) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002027@unknown@formal@none@1@S@Okadaic acid increased the synthesis of the interleukin-1 beta precursor and mature forms and their secretion.@(((:tag . "JJ") (:stem . "okadaic") (:form . "Okadaic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 99)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s225.6) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002028@unknown@formal@none@1@S@This increased processing and secretion correlated with the stimulation of IL-1 beta convertase mRNA accumulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "convertase") (:form . "convertase") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 113)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s225.7) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002030@unknown@formal@none@1@S@However, the phosphorylation of the precursor interleukin-1 alpha cytokine was increased.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s225.9) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002031@unknown@formal@none@1@S@These results show that protein phosphatase 1 and 2A inhibitors exert multiple effects on cytokine production in human monocytes and suggest that these two phosphatases play important roles in regulating interleukin-1 production.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 168)\n  (:start . 156) (:id . 66))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 183)\n  (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 189)\n  (:start . 184) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 203)\n  (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 217) (:start . 204) (:id . 72))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 228)\n  (:start . 218) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x225.10.1) (:span 133 140)))\n (:hscopes ((:id . :x225.10.1) (:span 133 228)))\n (:identifiers (:sid . :s225.10) (:did . :|93194883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002032@unknown@formal@none@1@S@Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "type-") (:form . "type-") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 29) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd20/b1") (:form . "CD20/B1") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s226.1) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002033@unknown@formal@none@1@S@The CD20 ( B1 ) gene encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 28)\n  (:start . 21) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 46) (:start . 33) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 111) (:start . 98) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 131) (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s226.2) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002034@unknown@formal@none@1@S@Studies with 5' deletion CD20 promoter-CAT constructs have previously revealed two regions of the promoter between bases -186 and -280 and between bases -280 and -454 which contained positive regulatory elements.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "cd20") (:form . "CD20") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter-cat") (:form . "promoter-CAT") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "CD") (:stem . "-186") (:form . "-186") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-280") (:form . "-280") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "CD") (:stem . "-280") (:form . "-280") (:end . 157) (:start . 153)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-454") (:form . "-454") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 182)\n  (:start . 173) (:id . 70))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 191)\n  (:start . 183) (:id . 71))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 202)\n  (:start . 192) (:id . 72))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 211)\n  (:start . 203) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s226.3) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002035@unknown@formal@none@1@S@In this study we identified a sequence element present in the most proximal region located between bases -214 and -201, TTCTTCTAATTAA, which is important in the high constitutive expression of CD20 in mature B cells and the induction of CD20 in pre-B cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-214") (:form . "-214") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-201") (:form . "-201") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TTCTTCTAATTAA") (:form . "TTCTTCTAATTAA")\n  (:end . 133) (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 153)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 178)\n  (:start . 166) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 189)\n  (:start . 179) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 209) (:start . 208)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 80))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 233)\n  (:start . 224) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 241) (:start . 237)\n  (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 244) (:start . 242)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 250)\n  (:start . 245) (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 256)\n  (:start . 251) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s226.4) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002036@unknown@formal@none@1@S@This sequence element was referred to as the BAT box and its deletion significantly reduced the activity of a CD20 promoter-CAT construct in B cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter-cat") (:form . "promoter-CAT") (:end . 127)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s226.5) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002037@unknown@formal@none@1@S@Mobility shift assays with various mutant probes and B cell nuclear extracts demonstrated that the core sequence TAAT was essential for binding to this site.@(((:tag . "NN") (:stem . "mobility") (:form . "Mobility") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "TAAT") (:form . "TAAT") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s226.6) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002038@unknown@formal@none@1@S@Cross competition experiments with an octamer sequence from the Ig heavy chain promoter, the BAT box, and a TA-rich sequence present in the CD21 promoter revealed that all three sequences bound the same nuclear proteins suggesting that the BAT box binding proteins were Oct-1 and Oct-2.@(((:tag . "NNP") (:stem . "Cross") (:form . "Cross") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . 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",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ta-rich") (:form . "TA-rich") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cd21") (:form . "CD21") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 153)\n  (:start . 145) (:id . 68))\n ((:tag . "VBD") (:stem . "reveal") (:form . 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"Oct-2") (:end . 285)\n  (:start . 280) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x226.7.1) (:span 220 230)))\n (:hscopes ((:id . :x226.7.1) (:span 220 285)))\n (:identifiers (:sid . :s226.7) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002040@unknown@formal@none@1@S@The affinity of the BAT box binding proteins for the BAT box was approximately 25-fold less than for the octamer sequence and the BAT box binding proteins dissociated from the BAT box 10-fold more rapidly than from the octamer sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 78) (:start . 65) (:id . 55))\n ((:tag . "RB") (:stem . "25-fold") (:form . "25-fold") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "VBN") (:stem . "dissociate") (:form . "dissociated") (:end . 166)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 191)\n  (:start . 184) (:id . 74))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 204)\n  (:start . 197) (:id . 76))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 209) (:start . 205)\n  (:id . 77))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 214) (:start . 210)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 79))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 226)\n  (:start . 219) (:id . 80))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 235)\n  (:start . 227) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s226.9) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002041@unknown@formal@none@1@S@Despite this lower affinity, a trimer of the BAT box sequence was as efficiently transactivated by an Oct-2 expression vector as was a trimer of the octamer sequence in HeLa cells.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "trimer") (:form . "trimer") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 80)\n  (:start . 69) (:id . 56))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 95) (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "trimer") (:form . "trimer") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 156)\n  (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 165)\n  (:start . 157) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 179)\n  (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s226.10) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002042@unknown@formal@none@1@S@The BAT box and Oct-2 were also implicated in the induction of CD20 in the pre-B cell line, PB-697, via phorbol esters.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PB-697") (:form . "PB-697") (:end . 98)\n  (:start . 92) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 103) (:start . 100)\n  (:id . 63))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 111)\n  (:start . 104) (:id . 64))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 118)\n  (:start . 112) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s226.11) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002043@unknown@formal@none@1@S@The induction of CD20 mRNA was temporally associated with induction of Oct-2 mRNA and a BAT box-deleted CD20-CAT construct, in contrast to the wild type, was poorly induced by phorbol esters.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "temporally") (:form . "temporally") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Oct-2") (:form . "Oct-2") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bat") (:form . "BAT") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "box-deleted") (:form . "box-deleted") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "NNP") (:stem . "CD20-CAT") (:form . "CD20-CAT") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 164)\n  (:start . 158) (:id . 70))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 172)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 183)\n  (:start . 176) (:id . 73))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 190)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s226.12) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002044@unknown@formal@none@1@S@Together these results suggest that the BAT box binding proteins are important in the B cell specific expression of CD20 and perhaps CD21.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BAT") (:form . "BAT") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "cd21") (:form . "CD21") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x226.13.1) (:span 125 132))\n  ((:id . :x226.13.2) (:span 23 30)))\n (:hscopes ((:id . :x226.13.1) (:span 125 137))\n  ((:id . :x226.13.2) (:span 23 137)))\n (:identifiers (:sid . :s226.13) (:did . :|93194904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002045@unknown@formal@none@1@S@Transcription factor jun-B is target of autoreactive T-cells in IDDM.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 26) (:start . 21)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "autoreactive") (:form . "autoreactive") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IDDM") (:form . "IDDM") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s227.1) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002046@unknown@formal@none@1@S@Target antigens defined by autoantibodies in IDDM include insulin, a putative glycolipid that reacts with islet cell antibodies, and a 64,000-M(r) protein recently identified as glutamic acid decarboxylase.@(((:tag . "NNP") (:stem . "Target") (:form . "Target") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "autoantibody") (:form . "autoantibodies")\n  (:end . 41) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IDDM") (:form . "IDDM") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "glycolipid") (:form . "glycolipid") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "react") (:form . "reacts") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "islet") (:form . "islet") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "64,000-M(r)") (:form . "64,000-M(r)") (:end . 146)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "glutamic") (:form . "glutamic") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "NN") (:stem . "decarboxylase") (:form . "decarboxylase")\n  (:end . 205) (:start . 192) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x227.2.1) (:span 69 77)))\n (:hscopes ((:id . :x227.2.1) (:span 69 88)))\n (:identifiers (:sid . :s227.2) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002047@unknown@formal@none@1@S@In addition, some IDDM sera that contain antibodies to glutamic acid decarboxylase also coprecipitate a 38,000-M(r) protein from islets.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IDDM") (:form . "IDDM") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "serum") (:form . "sera") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "glutamic") (:form . "glutamic") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "decarboxylase") (:form . "decarboxylase")\n  (:end . 82) (:start . 69) (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "coprecipitate") (:form . "coprecipitate")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "38,000-M(r)") (:form . "38,000-M(r)") (:end . 115)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "islet") (:form . "islets") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s227.3) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002048@unknown@formal@none@1@S@This study used a high titer anti-38,000-M(r) serum to screen bacteriophage lambda cDNA expression libraries and identified human islet and placental clones encoding jun-B, the nuclear transcription protein, of predicted 38,000 M(r).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "titer") (:form . "titer") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-38,000-M(r)") (:form . "anti-38,000-M(r)")\n  (:end . 45) (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "screen") (:form . "screen") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "bacteriophage") (:form . "bacteriophage")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "lambda") (:form . "lambda") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "library") (:form . "libraries") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "islet") (:form . "islet") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "placental") (:form . "placental") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 198) (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 206)\n  (:start . 199) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 220)\n  (:start . 211) (:id . 73))\n ((:tag . "CD") (:stem . "38,000") (:form . "38,000") (:end . 227)\n  (:start . 221) (:id . 74))\n ((:tag . "CD") (:stem . "M(r)") (:form . "M(r)") (:end . 232) (:start . 228)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s227.4) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002050@unknown@formal@none@1@S@Proliferation to tetanus toxoid did not differ significantly between the groups.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tetanus") (:form . "tetanus") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "toxoid") (:form . "toxoid") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x227.6.1) (:span 36 39)))\n (:nscopes ((:id . :x227.6.1) (:span 36 79)))\n (:identifiers (:sid . :s227.6) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002051@unknown@formal@none@1@S@Responses to jun-B were not related to age, sex, or human leukocyte antigen status.@(((:tag . "NNS") (:stem . "response") (:form . "Responses") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 67)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 75)\n  (:start . 68) (:id . 56))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x227.7.1) (:span 24 27)))\n (:nscopes ((:id . :x227.7.1) (:span 24 82)))\n (:identifiers (:sid . :s227.7) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002052@unknown@formal@none@1@S@Thus, autoreactive T-cells identify a novel antigen, p38 jun-B, in IDDM and appear to indicate subjects at risk for the development of clinical disease.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "autoreactive") (:form . "autoreactive") (:end . 18)\n  (:start . 6) (:id . 44))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IDDM") (:form . "IDDM") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 94)\n  (:start . 86) (:id . 59))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 131)\n  (:start . 120) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x227.8.1) (:span 76 82)))\n (:hscopes ((:id . :x227.8.1) (:span 76 151)))\n (:identifiers (:sid . :s227.8) (:did . :|93202345|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002053@unknown@formal@none@1@S@Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 41)\n  (:start . 30) (:id . 45))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 43) (:start . 42)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s228.1) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002054@unknown@formal@none@1@S@Role of AP-1- and octamer-binding proteins in control of IL3 gene expression.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ap-1-") (:form . "AP-1-") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 33) (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s228.2) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002055@unknown@formal@none@1@S@We have investigated the molecular and biochemical basis for activation of interleukin 3 (IL3) gene expression in primary human T lymphocytes following CD3 and CD2 receptor stimulation or activation by phytohemagglutinin plus phorbol 12-myristate 13-acetate.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 141)\n  (:start . 130) (:id . 64))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 184)\n  (:start . 173) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 198)\n  (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 220) (:start . 202) (:id . 74))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 225) (:start . 221)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 233)\n  (:start . 226) (:id . 76))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 246)\n  (:start . 234) (:id . 77))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 257)\n  (:start . 247) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s228.3) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002056@unknown@formal@none@1@S@Using transfection and reporter gene assays specifically designed for primary T lymphocytes in conjunction with gel retardation assays, Western blot analyses and UV cross-linking studies, we found that c-Jun, c-Fos, and octamer-binding proteins play a major role in transcriptional activation of the IL3 gene via their interaction with two specific regions contained within the IL3 5'-flanking sequence.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . 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"contained") (:end . 366)\n  (:start . 357) (:id . 97))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 373)\n  (:start . 367) (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 377) (:start . 374)\n  (:id . 99))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 381) (:start . 378)\n  (:id . 100))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 393)\n  (:start . 382) (:id . 101))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 402)\n  (:start . 394) (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 403) (:start . 402)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s228.4) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002057@unknown@formal@none@1@S@Additionally, the region between bases -107 and -59 of the IL3 promoter containing putative AP-2 and Sp1 binding motifs appears necessary for basal level expression of the IL3 gene.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-107") (:form . "-107") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-59") (:form . "-59") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 164)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x228.5.2) (:span 120 127))\n  ((:id . :x228.5.1) (:span 83 91)))\n (:hscopes ((:id . :x228.5.1) (:span 83 119))\n  ((:id . :x228.5.2) (:span 14 180)))\n (:identifiers (:sid . :s228.5) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002058@unknown@formal@none@1@S@The data also indicate that CD2 receptor activation and phytohemagglutinin plus phorbol 12-myristate 13-acetate stimulation augment T cell IL3 gene expression through the same cis- and trans-activating signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 74) (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 100)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 56))\n ((:tag . "VBP") (:stem . "augment") (:form . "augment") (:end . 131)\n  (:start . 124) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 142) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 166)\n  (:start . 159) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 175) (:start . 171)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cis-") (:form . "cis-") (:end . 180) (:start . 176)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 201) (:start . 185) (:id . 68))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 209)\n  (:start . 202) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x228.6.1) (:span 14 27)))\n (:hscopes ((:id . :x228.6.1) (:span 14 209)))\n (:identifiers (:sid . :s228.6) (:did . :|93203219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002060@unknown@formal@none@1@S@Transcriptional activation of human zeta 2 globin promoter by the alpha globin regulatory element (HS-40): functional role of specific nuclear factor-DNA complexes.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "factor-dna") (:form . "factor-DNA") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 163)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s229.1) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002061@unknown@formal@none@1@S@We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element (HS-40) located 40 kb upstream of the zeta 2 globin gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hs-40") (:form . "HS-40") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 176)\n  (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 181) (:start . 177)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s229.2) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002062@unknown@formal@none@1@S@It was shown by transient expression assay that HS-40 behaved as an authentic enhancer for high-level zeta 2 globin promoter activity in K562 cells, an erythroid cell line of embryonic and/or fetal origin.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "behave") (:form . "behaved") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "authentic") (:form . "authentic") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 161)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 184)\n  (:start . 175) (:id . 72))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 191)\n  (:start . 185) (:id . 73))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 197)\n  (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s229.3) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002063@unknown@formal@none@1@S@Although sequences located between -559 and -88 of the zeta 2 globin gene were dispensable for its expression on enhancerless plasmids, they were required for the HS-40 enhancer-mediated activity of the zeta 2 globin promoter.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "CD") (:stem . "-559") (:form . "-559") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-88") (:form . "-88") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dispensable") (:form . "dispensable") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "enhancerless") (:form . "enhancerless") (:end . 125)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . "JJ") (:stem . "enhancer-mediated") (:form . "enhancer-mediated")\n  (:end . 186) (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 209) (:start . 208)\n  (:id . 75))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 216)\n  (:start . 210) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 225)\n  (:start . 217) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s229.4) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002064@unknown@formal@none@1@S@Site-directed mutagenesis demonstrated that this HS-40 enhancer-zeta 2 globin promoter interaction is mediated by the two GATA-1 factor binding motifs located at -230 and -104, respectively.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hs-40") (:form . "HS-40") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer-zeta") (:form . "enhancer-zeta")\n  (:end . 68) (:start . 55) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 70) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 77)\n  (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 98)\n  (:start . 87) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 110)\n  (:start . 102) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 128)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 150)\n  (:start . 144) (:id . 61))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 158)\n  (:start . 151) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 161) (:start . 159)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-230") (:form . "-230") (:end . 166) (:start . 162)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "CD") (:stem . "-104") (:form . "-104") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 189)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s229.5) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002065@unknown@formal@none@1@S@The functional domains of HS-40 were also mapped.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 48) (:start . 42)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s229.6) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002066@unknown@formal@none@1@S@Bal 31 deletion mapping data suggested that one GATA-1 motif, one GT motif, and two NF-E2/AP1 motifs together formed the functional core of HS-40 in the erythroid-specific activation of the zeta 2 globin promoter.@(((:tag . "NNP") (:stem . "Bal") (:form . "Bal") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "31") (:form . "31") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gt") (:form . "GT") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nf-e2/ap1") (:form . "NF-E2/AP1") (:end . 93)\n  (:start . 84) (:id . 59))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 131)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hs-40") (:form . "HS-40") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 171) (:start . 153) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 182)\n  (:start . 172) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 196) (:start . 195)\n  (:id . 75))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 203)\n  (:start . 197) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 212)\n  (:start . 204) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x229.7.1) (:span 29 38)))\n (:hscopes ((:id . :x229.7.1) (:span 29 212)))\n (:identifiers (:sid . :s229.7) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002067@unknown@formal@none@1@S@Site-directed mutagenesis further demonstrated that the enhancer function of one of the two NF-E2/AP1 motifs of HS-40 is mediated through its binding to NF-E2 but not AP1 transcription factor.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 33)\n  (:start . 26) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 46)\n  (:start . 34) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nf-e2/ap1") (:form . "NF-E2/AP1") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 184) (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x229.8.1) (:span 163 166)))\n (:nscopes ((:id . :x229.8.1) (:span 163 191)))\n (:identifiers (:sid . :s229.8) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002068@unknown@formal@none@1@S@Finally, we did genomic footprinting of the HS-40 enhancer region in K562 cells, adult nucleated erythroblasts, and different nonerythroid cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nucleated") (:form . "nucleated") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 110) (:start . 97) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "JJ") (:stem . "nonerythroid") (:form . "nonerythroid") (:end . 138)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s229.9) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002070@unknown@formal@none@1@S@On the other hand, only one of the apparently nonfunctional sequence motifs was bound with factors in vivo.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 45)\n  (:start . 35) (:id . 51))\n ((:tag . "JJ") (:stem . "nonfunctional") (:form . "nonfunctional")\n  (:end . 59) (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s229.11) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002071@unknown@formal@none@1@S@In comparison to K562, nucleated erythroblasts from adult human bone marrow exhibited a similar but nonidentical pattern of nuclear factor binding in vivo at the HS-40 region.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nucleated") (:form . "nucleated") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonidentical") (:form . "nonidentical") (:end . 112)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "hs-40") (:form . "HS-40") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 174)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s229.12) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002072@unknown@formal@none@1@S@These data suggest that transcriptional activation of human embryonic zeta 2 globin gene and the fetal/adult alpha globin genes is mediated by erythroid cell-specific and developmental stage-specific nuclear factor-DNA complexes which form at the enhancer (HS-40) and the globin promoters.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "fetal/adult") (:form . "fetal/adult") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 166) (:start . 153) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 184) (:start . 171) (:id . 67))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 199) (:start . 185) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 207)\n  (:start . 200) (:id . 69))\n ((:tag . "NN") (:stem . "factor-dna") (:form . "factor-DNA") (:end . 218)\n  (:start . 208) (:id . 70))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 228)\n  (:start . 219) (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 234)\n  (:start . 229) (:id . 72))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 239) (:start . 235)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 242) (:start . 240)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 75))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 255)\n  (:start . 247) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 257) (:start . 256)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "HS-40") (:form . "HS-40") (:end . 262)\n  (:start . 257) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 263) (:start . 262)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 267) (:start . 264)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 271) (:start . 268)\n  (:id . 81))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 278)\n  (:start . 272) (:id . 82))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 288)\n  (:start . 279) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x229.13.1) (:span 11 18)))\n (:hscopes ((:id . :x229.13.1) (:span 11 288)))\n (:identifiers (:sid . :s229.13) (:did . :|93204975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002073@unknown@formal@none@1@S@Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.@(((:tag . "NNP") (:stem . "Interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NNP") (:stem . "B-") (:form . "B-") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "factor-binding") (:form . "factor-binding")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 101) (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 110)\n  (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 122)\n  (:start . 111) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 131)\n  (:start . 123) (:id . 56))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 144)\n  (:start . 132) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 149) (:start . 148)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 161)\n  (:start . 150) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s230.1) (:did . :|93204999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002074@unknown@formal@none@1@S@We find that a short enhancer element containing the NF-kappa B binding site from the interleukin-2 receptor alpha-chain gene (IL-2R alpha) is preferentially activated in T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 99) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 157) (:start . 143) (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s230.2) (:did . :|93204999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002075@unknown@formal@none@1@S@The IL-2R alpha enhancer binds NF-kappa B poorly and is only weakly activated by the NF-kappa B site alone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s230.3) (:did . :|93204999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002076@unknown@formal@none@1@S@Serum response factor (SRF) binds to a site adjacent to the NF-kappa B site in the IL-2R enhancer, and both sites together have strong transcriptional activity specifically in T cells.@(((:tag . "NNP") (:stem . "Serum") (:form . "Serum") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 52)\n  (:start . 44) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 97)\n  (:start . 89) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 63))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 113)\n  (:start . 108) (:id . 65))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 122)\n  (:start . 114) (:id . 66))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 127) (:start . 123)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 134)\n  (:start . 128) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 150) (:start . 135) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 159)\n  (:start . 151) (:id . 70))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 172)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s230.4) (:did . :|93204999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002077@unknown@formal@none@1@S@Surprisingly, the levels of SRF constitutively expressed in T cells are consistently higher than in other cell types.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 46) (:start . 32) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 91) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s230.5) (:did . :|93204999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002078@unknown@formal@none@1@S@Overexpression of SRF in B cells causes the IL-2R enhancer to function as well as it does in T cells, suggesting that the high level of SRF binding in T cells is functionally important.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 112)\n  (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 126) (:start . 122)\n  (:id . 66))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 132)\n  (:start . 127) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 74))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 174)\n  (:start . 162) (:id . 75))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 184)\n  (:start . 175) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x230.6.1) (:span 102 112)))\n (:hscopes ((:id . :x230.6.1) (:span 102 184)))\n (:identifiers (:sid . :s230.6) (:did . :|93204999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002080@unknown@formal@none@1@S@The transactivator HTLV-I Tax activates the promoter of the gene coding for the interleukin 2 alpha-chain receptor (IL-2R alpha) via a kappa B site that can bind several protein species of the rel family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 71) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 161) (:start . 157)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 169)\n  (:start . 162) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 177)\n  (:start . 170) (:id . 72))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 185)\n  (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 196) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 203)\n  (:start . 197) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s231.2) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002081@unknown@formal@none@1@S@Tax1 strongly activates the enhancer activity of this motif, in both epithelial HeLa and lymphoid Jurkat cells.@(((:tag . "NNP") (:stem . "Tax1") (:form . "Tax1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s231.3) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002082@unknown@formal@none@1@S@This activation was not observed in undifferentiated embryocarcinoma F9 cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "undifferentiated") (:form . "undifferentiated")\n  (:end . 52) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "embryocarcinoma") (:form . "embryocarcinoma")\n  (:end . 68) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "f9") (:form . "F9") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x231.4.1) (:span 20 23)))\n (:nscopes ((:id . :x231.4.1) (:span 0 77)))\n (:identifiers (:sid . :s231.4) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002083@unknown@formal@none@1@S@Overexpression of the p50, p65 and Rel proteins in these cells showed that significant activation of the IL-2R alpha kappa B site was observed only with Rel and Rel plus p65.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 69) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 86)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 169) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s231.5) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002084@unknown@formal@none@1@S@Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 138)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 144)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 162) (:start . 159)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 165) (:start . 163)\n  (:id . 73))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 178)\n  (:start . 166) (:id . 74))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 187)\n  (:start . 179) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s231.6) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002085@unknown@formal@none@1@S@Using the DNA affinity precipitation assay, we observed that Tax1 is able to efficiently induce the binding of Rel, whereas PMA is not.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "precipitation") (:form . "precipitation")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tax1") (:form . "Tax1") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x231.7.1) (:span 131 134)))\n (:nscopes ((:id . :x231.7.1) (:span 131 134)))\n (:identifiers (:sid . :s231.7) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002086@unknown@formal@none@1@S@This established a clear difference between both stimuli, indicating that Rel is the functionally active factor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x231.8.1) (:span 58 73)))\n (:hscopes ((:id . :x231.8.1) (:span 58 111)))\n (:identifiers (:sid . :s231.8) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002087@unknown@formal@none@1@S@We conclude from these results that the functional activity of members of the rel family is regulated by their interaction with DNA and that Rel can be a potent transcriptional activator on specific kappa B sites.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 122)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 160)\n  (:start . 154) (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 176) (:start . 161) (:id . 71))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 186)\n  (:start . 177) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 198)\n  (:start . 190) (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 204)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 212)\n  (:start . 207) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x231.9.1) (:span 154 160))\n  ((:id . :x231.9.2) (:span 145 148)))\n (:hscopes ((:id . :x231.9.1) (:span 154 212))\n  ((:id . :x231.9.2) (:span 145 212)))\n (:identifiers (:sid . :s231.9) (:did . :|93205400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002088@unknown@formal@none@1@S@NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 101) (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s232.1) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002090@unknown@formal@none@1@S@Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor I kappa B alpha.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s232.3) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002091@unknown@formal@none@1@S@Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-kappa B is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression.@(((:tag . "NNP") (:stem . "Phorbol") (:form . "Phorbol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 117)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 200)\n  (:start . 190) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s232.4) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002092@unknown@formal@none@1@S@Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 75)\n  (:start . 63) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "65-kilodalton") (:form . "65-kilodalton")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "transactivating") (:form . "transactivating")\n  (:end . 120) (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x232.5.1) (:span 21 34)))\n (:hscopes ((:id . :x232.5.1) (:span 21 142)))\n (:identifiers (:sid . :s232.5) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002093@unknown@formal@none@1@S@Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor.@(((:tag . "NNP") (:stem . "Association") (:form . "Association") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "restore") (:form . "restores") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 84) (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "prolong") (:form . "prolongs") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "labile") (:form . "labile") (:end . 171)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s232.6) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002094@unknown@formal@none@1@S@Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 112)\n  (:start . 103) (:id . 62))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 127) (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s232.7) (:did . :|93206138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002095@unknown@formal@none@1@S@p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.@(((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p98") (:form . "p98") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s233.1) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002096@unknown@formal@none@1@S@The Rel/NF-kappa B family of transcription factors is composed of two distinct subgroups, proteins that undergo proteolytic processing and contain SWI6/ankyrin repeats in their carboxyl termini (p105, p98), and those without such repeats that do not require processing (p65, c-Rel, RelB, and Dorsal).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . 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(:end . 300) (:start . 299)\n  (:id . 95)))@@@1@54@((:ncues ((:id . :x233.2.1) (:span 246 249))\n  ((:id . :x233.2.2) (:span 217 224)))\n (:nscopes ((:id . :x233.2.1) (:span 246 299))\n  ((:id . :x233.2.2) (:span 217 237)))\n (:identifiers (:sid . :s233.2) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002097@unknown@formal@none@1@S@We demonstrate that the p105 and p98 precursors share functional properties with the I kappa B proteins, which also contain SWI6/ankyrin repeats.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p98") (:form . "p98") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "SWI6/ankyrin") (:form . "SWI6/ankyrin")\n  (:end . 136) (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s233.3) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002098@unknown@formal@none@1@S@Both p105 and p98 were found to form stable complexes with other Rel/NF-kappa B family members, including p65 and c-Rel.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p98") (:form . "p98") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 77)\n  (:start . 65) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s233.4) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002100@unknown@formal@none@1@S@These complexes undergo stimulus-responsive processing to produce active p50/c-Rel and p55/c-Rel complexes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "stimulus-responsive")\n  (:form . "stimulus-responsive") (:end . 43) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 54)\n  (:start . 44) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 47))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 72)\n  (:start . 66) (:id . 49))\n ((:tag . "NN") (:stem . "p50/c-rel") (:form . "p50/c-Rel") (:end . 82)\n  (:start . 73) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p55/c-rel") (:form . "p55/c-Rel") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 106)\n  (:start . 97) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s233.6) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002101@unknown@formal@none@1@S@These observations suggest a second pathway leading to NF-kappa B induction, in which processing of the precursors rather than phosphorylation of I kappa B plays a major role.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 121)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 142) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x233.7.2) (:span 19 26)))\n (:ncues ((:id . :x233.7.1) (:span 115 126)))\n (:hscopes ((:id . :x233.7.2) (:span 19 174)))\n (:nscopes ((:id . :x233.7.1) (:span 115 155)))\n (:identifiers (:sid . :s233.7) (:did . :|93209552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002102@unknown@formal@none@1@S@Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.@(((:tag . "JJ") (:stem . "mutual") (:form . "Mutual") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s234.1) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002103@unknown@formal@none@1@S@The NK-kappa B transcription factor complex is sequestered in the cytoplasm by the inhibitory protein I kappa B-alpha (MAD-3).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NK-kappa") (:form . "NK-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "sequester") (:form . "sequestered") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "I") (:form . "I") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "MAD-3") (:form . "MAD-3") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s234.2) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002104@unknown@formal@none@1@S@Various cellular stimuli relieve this inhibition by mechanisms largely unknown, leading to NF-kappa B nuclear localization and transactivation of its target genes.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "relieve") (:form . "relieve") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 122)\n  (:start . 110) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 142) (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 162)\n  (:start . 157) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s234.3) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002105@unknown@formal@none@1@S@It is demonstrated here with human T lymphocytes and monocytes that different stimuli, including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate, cause rapid degradation of I kappa B-alpha, with concomitant activation of NF-kappa B, followed by a dramatic increase in I kappa B-alpha mRNA and protein synthesis .@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 18)\n  (:start . 6) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . 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"NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 299)\n  (:start . 292) (:id . 89))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 304) (:start . 300)\n  (:id . 90))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 308) (:start . 305)\n  (:id . 91))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 316)\n  (:start . 309) (:id . 92))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 326)\n  (:start . 317) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 328) (:start . 327)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s234.4) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002106@unknown@formal@none@1@S@Transfection studies reveal that the I kappa B-alpha mRNA and the encoded protein are potently induced by NF-kappa B and by homodimers of p65 and of c-Rel.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 134)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s234.5) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002107@unknown@formal@none@1@S@We propose a model in which NF-kappa B and I kappa B-alpha mutually regulate each other in a cycle:@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "RB") (:stem . "mutually") (:form . "mutually") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 99) (:start . 98)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x234.6.1) (:span 3 10)))\n (:hscopes ((:id . :x234.6.1) (:span 3 98)))\n (:identifiers (:sid . :s234.6) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002108@unknown@formal@none@1@S@saturating amounts of the inhibitory I kappa B-alpha protein are destroyed upon stimulation, allowing rapid activation of NF-kappa B.@(((:tag . "VBG") (:stem . "saturate") (:form . "saturating") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "destroy") (:form . "destroyed") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s234.7) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002110@unknown@formal@none@1@S@This resurgence of I kappa B-alpha protein acts to restore an equilibrium in which NF-kappa B is again inhibited.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "resurgence") (:form . "resurgence") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "equilibrium") (:form . "equilibrium") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s234.9) (:did . :|93211996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002111@unknown@formal@none@1@S@Induced myeloid differentiation of K562 cells with downregulation of erythroid and megakaryocytic transcription factors: a novel experimental model for hemopoietic lineage restriction.@(((:tag . "VBN") (:stem . "induce") (:form . "Induced") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 31) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 97) (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 119)\n  (:start . 112) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 120) (:start . 119)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 128)\n  (:start . 123) (:id . 58))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 141)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 147)\n  (:start . 142) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 163)\n  (:start . 152) (:id . 62))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 171)\n  (:start . 164) (:id . 63))\n ((:tag . "NN") (:stem . "restriction") (:form . "restriction") (:end . 183)\n  (:start . 172) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s235.1) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002112@unknown@formal@none@1@S@The human erythroleukemia cell line K562 can be induced to differentiate along the erythroid and megakaryocytic lineages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 111) (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s235.2) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002113@unknown@formal@none@1@S@Here we demonstrate that hexamethylene bisacetamide (HMBA) induced K562 cells to differentiate along a third pathway.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hexamethylene") (:form . "hexamethylene")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "bisacetamide") (:form . "bisacetamide") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HMBA") (:form . "HMBA") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s235.3) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002114@unknown@formal@none@1@S@This was accompanied by downregulation of two transcription factors normally expressed in erythroid, mast and megakaryocyte lineages.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s235.4) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002115@unknown@formal@none@1@S@Northern analysis demonstrated coordinate downregulation of alpha globin and gamma globin in addition to the two lineage-restricted transcription factors, SCL and GATA-1.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 56) (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 72)\n  (:start . 66) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lineage-restricted") (:form . "lineage-restricted")\n  (:end . 131) (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 145) (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 153)\n  (:start . 146) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 169)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s235.5) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002116@unknown@formal@none@1@S@Proliferation of the K562 cells was also suppressed.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s235.6) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002117@unknown@formal@none@1@S@Clonal assay showed that the suppression was irreversible and appeared analogous to the commitment of murine erythroleukemia (MEL) cells to terminal differentiation.@(((:tag . "JJ") (:stem . "clonal") (:form . "Clonal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 19) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 124) (:start . 109) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MEL") (:form . "MEL") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 164) (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x235.7.1) (:span 62 70)))\n (:hscopes ((:id . :x235.7.1) (:span 62 164)))\n (:identifiers (:sid . :s235.7) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002118@unknown@formal@none@1@S@In contrast to MEL cells, however, K562 cells acquired a macrophage-like morphology and exhibited a complete failure to generate benzidine-positive cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MEL") (:form . "MEL") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "acquire") (:form . "acquired") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 72) (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "JJ") (:stem . "benzidine-positive") (:form . "benzidine-positive")\n  (:end . 147) (:start . 129) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s235.8) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002120@unknown@formal@none@1@S@Surface marker analysis showed that HMBA-induced cells expressed reduced levels of glycophorin A, CD5, CD7 and CD11b.@(((:tag . "NN") (:stem . "surface") (:form . "Surface") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 30) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hmba-induced") (:form . "HMBA-induced") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glycophorin") (:form . "glycophorin") (:end . 94)\n  (:start . 83) (:id . 53))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD7") (:form . "CD7") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s235.10) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002121@unknown@formal@none@1@S@No upregulation of megakaryocyte or lymphoid markers occurred.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x235.11.1) (:span 0 2)))\n (:nscopes ((:id . :x235.11.1) (:span 0 61)))\n (:identifiers (:sid . :s235.11) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002122@unknown@formal@none@1@S@Thus the response of K562 cells to HMBA may provide a useful experimental system for studying the molecular mechanisms responsible for downmodulation of lineage-restricted transcription factors during hemopoietic lineage commitment.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HMBA") (:form . "HMBA") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 73)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "downmodulation") (:form . "downmodulation")\n  (:end . 149) (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lineage-restricted") (:form . "lineage-restricted")\n  (:end . 171) (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 185) (:start . 172) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 193)\n  (:start . 186) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 200)\n  (:start . 194) (:id . 68))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 212)\n  (:start . 201) (:id . 69))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 220)\n  (:start . 213) (:id . 70))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 231)\n  (:start . 221) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x235.12.1) (:span 40 43)))\n (:hscopes ((:id . :x235.12.1) (:span 40 231)))\n (:identifiers (:sid . :s235.12) (:did . :|93215800|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002123@unknown@formal@none@1@S@The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 129) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s236.1) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002124@unknown@formal@none@1@S@The myeloid integrin CD11b is expressed selectively on the surface of mature macrophages, monocytes, neutrophils, and natural killer cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s236.2) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002125@unknown@formal@none@1@S@Lineage-specific expression is controlled at the level of mRNA transcription.@(((:tag . "JJ") (:stem . "lineage-specific") (:form . "Lineage-specific")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s236.3) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002126@unknown@formal@none@1@S@Recent isolation of the CD11b promoter shows that 92 base pairs (bp) of 5'-flanking DNA are sufficient to direct myeloid-specific expression of a reporter gene.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "CD") (:stem . "92") (:form . "92") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 83)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 102)\n  (:start . 92) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 129) (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s236.4) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002127@unknown@formal@none@1@S@To characterize regulatory sequences important for promoter activity, we performed linker scanning analysis of the 92-bp CD11b promoter and demonstrate that a sequence at bp -60 is essential for CD11b promoter activity.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "linker") (:form . "linker") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "scanning") (:form . "scanning") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "92-bp") (:form . "92-bp") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 151)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 167)\n  (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-60") (:form . "-60") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 190)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 200)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 209)\n  (:start . 201) (:id . 73))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 218)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s236.5) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002128@unknown@formal@none@1@S@We show that this sequence binds the transcription factor Sp1 in vitro and in vivo.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s236.6) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002130@unknown@formal@none@1@S@In addition, the macrophage transcription factor PU.1 binds the CD11b promoter in vitro and in vivo close to the Sp1 site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "RB") (:stem . "close") (:form . "close") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s236.8) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002131@unknown@formal@none@1@S@We propose a model in which binding of a myeloid-specific factor (PU.1) allows a general factor (Sp1) to bind in a tissue-specific fashion thereby contributing to the myeloid-specific expression of CD11b.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 57) (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 88)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 63))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 109) (:start . 105)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 130) (:start . 115) (:id . 67))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 138)\n  (:start . 131) (:id . 68))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 146)\n  (:start . 139) (:id . 69))\n ((:tag . "VBG") (:stem . "contribute") (:form . "contributing") (:end . 159)\n  (:start . 147) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 183) (:start . 167) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 194)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 203)\n  (:start . 198) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x236.9.1) (:span 3 10)))\n (:hscopes ((:id . :x236.9.1) (:span 3 203)))\n (:identifiers (:sid . :s236.9) (:did . :|93216805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002132@unknown@formal@none@1@S@Costimulation of peripheral blood T cell activation by human endothelial cells.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 72)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s237.1) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002133@unknown@formal@none@1@S@Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 59) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 69)\n  (:start . 60) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "fos") (:form . "Fos") (:end . 87) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s237.2) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002134@unknown@formal@none@1@S@Endothelial cells (EC) act as APC for resting PBL in vitro, and may have important roles in vivo in the pathogenesis of allograft rejection and delayed hypersensitivity.@(((:tag . "JJ") (:stem . "endothelial") (:form . "Endothelial") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 58) (:start . 53)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 67) (:start . 64)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 72) (:start . 68)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 82)\n  (:start . 73) (:id . 59))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 96) (:start . 92)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 116)\n  (:start . 104) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 66))\n ((:tag . "NN") (:stem . "allograft") (:form . "allograft") (:end . 129)\n  (:start . 120) (:id . 67))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 139)\n  (:start . 130) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 151)\n  (:start . 144) (:id . 70))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 168) (:start . 152) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x237.3.1) (:span 64 67)))\n (:hscopes ((:id . :x237.3.1) (:span 64 168)))\n (:identifiers (:sid . :s237.3) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002135@unknown@formal@none@1@S@We previously reported that human umbilical vein EC provide costimulatory signals to PHA-stimulated PBL via CD2:lymphocyte function-associated Ag-3 and an unidentified ligand pair, resulting in a three- to eight-fold enhancement of IL-2 production.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "pha-stimulated") (:form . "PHA-stimulated")\n  (:end . 99) (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD2:lymphocyte") (:form . "CD2:lymphocyte")\n  (:end . 122) (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "function-associated")\n  (:form . "function-associated") (:end . 142) (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "ag-3") (:form . "Ag-3") (:end . 147) (:start . 143)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 154) (:start . 152)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 167)\n  (:start . 155) (:id . 62))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 174)\n  (:start . 168) (:id . 63))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 179) (:start . 175)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 190)\n  (:start . 181) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 195) (:start . 194)\n  (:id . 68))\n ((:tag . "CD") (:stem . "three-") (:form . "three-") (:end . 202)\n  (:start . 196) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 205) (:start . 203)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "eight-fold") (:form . "eight-fold") (:end . 216)\n  (:start . 206) (:id . 71))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 228)\n  (:start . 217) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 236) (:start . 232)\n  (:id . 74))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 247)\n  (:start . 237) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s237.4) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002136@unknown@formal@none@1@S@The physiologic relevance of this increase was demonstrated by the proliferative advantage provided by EC to PBL suboptimally stimulated with mAb OKT3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "RB") (:stem . "suboptimally") (:form . "suboptimally") (:end . 125)\n  (:start . 113) (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 136)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "okt3") (:form . "OKT3") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s237.5) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002137@unknown@formal@none@1@S@We now report that EC costimulation causes increased levels of IL-2 mRNA as a result of increased IL-2 transcription in PBL.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s237.6) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002138@unknown@formal@none@1@S@We therefore examined the effects of EC on T cell nuclear factors known to regulate IL-2 transcription, including c-jun and c-fos-two components of the transcription factor AP-1, NFAT, and others.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "c-fos-two") (:form . "c-fos-two") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 165) (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 172)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 195)\n  (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s237.7) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002140@unknown@formal@none@1@S@In contrast, c-fos mRNA is absent from resting T cells and is induced on PHA activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 69)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s237.9) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002141@unknown@formal@none@1@S@EC alone do not induce c-fos mRNA but augment the level of c-fos mRNA in PHA-activated T cells by 3- to 10-fold.@(((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "augment") (:form . "augment") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 86) (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "CD") (:stem . "3-") (:form . "3-") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 111)\n  (:start . 104) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x237.10.1) (:span 12 15)))\n (:nscopes ((:id . :x237.10.1) (:span 12 33)))\n (:identifiers (:sid . :s237.10) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002142@unknown@formal@none@1@S@This effect is largely independent of the CD2:lymphocyte function-associated Ag-3 pathway.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD2:lymphocyte") (:form . "CD2:lymphocyte")\n  (:end . 56) (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "function-associated")\n  (:form . "function-associated") (:end . 76) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "ag-3") (:form . "Ag-3") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s237.11) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002143@unknown@formal@none@1@S@Gel-shift analysis reveals the constitutive presence of nuclear factors in resting PBL that bind to the proximal AP-1 site of the IL-2 promoter and that contain immunoreactive c-Jun but not c-Fos protein.@(((:tag . "JJ") (:stem . "gel-shift") (:form . "Gel-shift") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 160)\n  (:start . 153) (:id . 67))\n ((:tag . "JJ") (:stem . "immunoreactive") (:form . "immunoreactive")\n  (:end . 175) (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 181)\n  (:start . 176) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 195)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 203)\n  (:start . 196) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x237.12.1) (:span 186 189)))\n (:nscopes ((:id . :x237.12.1) (:span 186 203)))\n (:identifiers (:sid . :s237.12) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002144@unknown@formal@none@1@S@In contrast, AP-1 from PHA-activated cells contains c-Jun and low levels of c-Fos.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s237.13) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002145@unknown@formal@none@1@S@Strikingly, costimulation with EC results in a dramatic increase (up to 15-fold) in the c-Fos content of AP-1.@(((:tag . "RB") (:stem . "strikingly") (:form . "Strikingly") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "15-fold") (:form . "15-fold") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s237.14) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002146@unknown@formal@none@1@S@Levels of other nuclear factors involved in IL-2 regulation were not altered by EC, although NFAT-DNA complexes migrated at a slightly different mobility.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT-DNA") (:form . "NFAT-DNA") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "VBD") (:stem . "migrate") (:form . "migrated") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x237.15.1) (:span 65 68)))\n (:nscopes ((:id . :x237.15.1) (:span 0 82)))\n (:identifiers (:sid . :s237.15) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002147@unknown@formal@none@1@S@In summary, our data suggest that changes in the composition of transcription factor AP-1 is a key molecular mechanism for increasing IL-2 transcription and may underlie the phenomenon of costimulation by EC.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 60)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 184)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 201) (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x237.16.1) (:span 157 160))\n  ((:id . :x237.16.2) (:span 21 28)))\n (:hscopes ((:id . :x237.16.1) (:span 157 207))\n  ((:id . :x237.16.2) (:span 21 207)))\n (:identifiers (:sid . :s237.16) (:did . :|93224719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002148@unknown@formal@none@1@S@A protein of the AP-1 family is a component of nuclear factor of activated T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 43)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s238.1) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002150@unknown@formal@none@1@S@The response element for NF-AT is a sequence localized between -285/-254 in the IL-2 regulatory region.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "CD") (:stem . "-285/-254") (:form . "-285/-254") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s238.3) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002151@unknown@formal@none@1@S@The composition of NF-AT protein is still not fully elucidated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x238.4.1) (:span 42 45)))\n (:nscopes ((:id . :x238.4.1) (:span 0 62)))\n (:identifiers (:sid . :s238.4) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002152@unknown@formal@none@1@S@We demonstrate that , in normal human T cells, an AP-1 protein is a component of the NF-AT protein complex.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 77)\n  (:start . 68) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 61))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 106)\n  (:start . 99) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s238.5) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002153@unknown@formal@none@1@S@This was evidenced by the ability of the AP-1 site to compete with the NF-AT site for binding to NF-AT and by the capacity of immobilized anti-Jun and anti-Fos antibodies to deplete NF-AT-binding activity from nuclear extracts of activated T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 93)\n  (:start . 86) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 102)\n  (:start . 97) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 122)\n  (:start . 114) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "immobilize") (:form . "immobilized") (:end . 137)\n  (:start . 126) (:id . 67))\n ((:tag . "JJ") (:stem . "anti-jun") (:form . "anti-Jun") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "anti-fos") (:form . "anti-Fos") (:end . 159)\n  (:start . 151) (:id . 70))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 170)\n  (:start . 160) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "VB") (:stem . "deplete") (:form . "deplete") (:end . 181)\n  (:start . 174) (:id . 73))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 195) (:start . 182) (:id . 74))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 204)\n  (:start . 196) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 217)\n  (:start . 210) (:id . 77))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 226)\n  (:start . 218) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 239)\n  (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 241) (:start . 240)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 247)\n  (:start . 242) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s238.6) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002154@unknown@formal@none@1@S@There was no detectable binding of in vitro translated Jun/Fos heterodimer (AP-1) to the NF-AT sequence, and the NF-AT sequence was unable to inhibit the binding of Jun/Fos to the AP-1 sequence.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "Jun/Fos") (:form . "Jun/Fos") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 127)\n  (:start . 119) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 138)\n  (:start . 132) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 149)\n  (:start . 142) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 161)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "jun/fos") (:form . "Jun/Fos") (:end . 172)\n  (:start . 165) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 184) (:start . 180)\n  (:id . 75))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 193)\n  (:start . 185) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x238.7.1) (:span 132 138))\n  ((:id . :x238.7.2) (:span 10 12)))\n (:nscopes ((:id . :x238.7.1) (:span 132 193))\n  ((:id . :x238.7.2) (:span 10 103)))\n (:identifiers (:sid . :s238.7) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002155@unknown@formal@none@1@S@The presence of an AP-1 protein in the NF-AT protein complex may regulate NF-AT-binding activity through protein-protein interaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 87) (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 120) (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 132)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x238.8.1) (:span 61 64)))\n (:hscopes ((:id . :x238.8.1) (:span 61 132)))\n (:identifiers (:sid . :s238.8) (:did . :|93224733|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002156@unknown@formal@none@1@S@Functional antagonism between vitamin D3 and retinoic acid in the regulation of CD14 and CD23 expression during monocytic differentiation of U-937 cells.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "antagonism") (:form . "antagonism") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 137) (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s239.1) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002157@unknown@formal@none@1@S@1,25 alpha-Dihydroxicholecalciferol (VitD3) and retinoic acid (RA) are important regulators of the proliferation and differentiation of several cell types.@(((:tag . "CD") (:stem . "1,25") (:form . "1,25") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha-dihydroxicholecalciferol")\n  (:form . "alpha-Dihydroxicholecalciferol") (:end . 35) (:start . 5)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 42) (:start . 37)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 132) (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s239.2) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002158@unknown@formal@none@1@S@This paper describes how the expression of the monocyte-macrophage Ag, CD14, and the low affinity Fc receptor for IgE, CD23, were inversely regulated during VitD3- and RA-induced monocytic differentiation of human U-937 monoblasts.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophage") (:end . 66) (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . "RB") (:stem . "inversely") (:form . "inversely") (:end . 139)\n  (:start . 130) (:id . 67))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 149)\n  (:start . 140) (:id . 68))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . "NNP") (:stem . "VitD3-") (:form . "VitD3-") (:end . 163)\n  (:start . 157) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "ra-induced") (:form . "RA-induced") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 188)\n  (:start . 179) (:id . 73))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 204) (:start . 189) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 219)\n  (:start . 214) (:id . 77))\n ((:tag . "NNS") (:stem . "monoblast") (:form . "monoblasts") (:end . 230)\n  (:start . 220) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s239.3) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002160@unknown@formal@none@1@S@Exposure to VitD3 rapidly induced the de novo expression of CD14 mRNA and protein.@(((:tag . "NN") (:stem . "exposure") (:form . "Exposure") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s239.5) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002161@unknown@formal@none@1@S@The addition of cycloheximide completely blocked the VitD3 induction of CD14 mRNA expression, indicating that the induction was dependent on ongoing protein synthesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ongoing") (:form . "ongoing") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 166)\n  (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x239.6.1) (:span 94 109)))\n (:hscopes ((:id . :x239.6.1) (:span 94 166)))\n (:identifiers (:sid . :s239.6) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002162@unknown@formal@none@1@S@While inducing CD14 expression, VitD3 concomitantly suppressed the basal, PMA-, and RA-inducible CD23 expression in a dose-dependent manner.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pma-") (:form . "PMA-") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ra-inducible") (:form . "RA-inducible") (:end . 96)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 132) (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s239.7) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002163@unknown@formal@none@1@S@In contrast, U-937 cells induced by RA strongly increased their expression of CD23 mRNA and protein, whereas they completely lacked detectable CD14 cell surface or mRNA expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 63)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . "VBD") (:stem . "lack") (:form . "lacked") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 160)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x239.8.1) (:span 125 131)))\n (:nscopes ((:id . :x239.8.1) (:span 125 179)))\n (:identifiers (:sid . :s239.8) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002164@unknown@formal@none@1@S@Furthermore, the VitD3- and the PMA-induced CD14 expression was inhibited as a temporal consequence of the RA-induced differentiation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "vitd3-") (:form . "VitD3-") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ra-induced") (:form . "RA-induced") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 133) (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s239.9) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002165@unknown@formal@none@1@S@The results suggest that there exists a functional antagonism between VitD3 and RA that may have important implications for the regulation of certain immune and inflammatory responses through their inverse effects on CD14 and CD23 gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "antagonism") (:form . "antagonism") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 119)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 156)\n  (:start . 150) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 173)\n  (:start . 161) (:id . 67))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 183)\n  (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 191)\n  (:start . 184) (:id . 69))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 197)\n  (:start . 192) (:id . 70))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 205)\n  (:start . 198) (:id . 71))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 213)\n  (:start . 206) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 216) (:start . 214)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 221) (:start . 217)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 230) (:start . 226)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 235) (:start . 231)\n  (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 246)\n  (:start . 236) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x239.10.1) (:span 88 91))\n  ((:id . :x239.10.2) (:span 12 19)))\n (:hscopes ((:id . :x239.10.1) (:span 88 246))\n  ((:id . :x239.10.2) (:span 12 246)))\n (:identifiers (:sid . :s239.10) (:did . :|93224755|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002166@unknown@formal@none@1@S@The lytic transition of Epstein-Barr virus is imitated by recombinant B-cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "imitate") (:form . "imitated") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "b-cell") (:form . "B-cells") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s240.1) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002167@unknown@formal@none@1@S@Lytic transition of Epstein-Barr virus (EBV) is initiated by distinct immediate early regulators of the viral cycle, in synchronization to temporary, permissive conditions during host cell differentiation.@(((:tag . "JJ") (:stem . "lytic") (:form . "Lytic") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synchronization") (:form . "synchronization")\n  (:end . 135) (:start . 120) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "temporary") (:form . "temporary") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 160)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 171)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 178)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 204) (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s240.2) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002168@unknown@formal@none@1@S@We developed eukaryotic vectors suitable to imitate the processes involved in lytic transition in cell culture systems.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "suitable") (:form . "suitable") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VB") (:stem . "imitate") (:form . "imitate") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s240.3) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002170@unknown@formal@none@1@S@R59Z activator cells were used to induce lytic EBV expression in a constitutive manner by the production of the BZLF 1 trans-activator (Zta).@(((:tag . "NNP") (:stem . "R59Z") (:form . "R59Z") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 79)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "BZLF") (:form . "BZLF") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 134) (:start . 119) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Zta") (:form . "Zta") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s240.5) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002171@unknown@formal@none@1@S@R7-57 reporter cells, on the other hand, signaled induced activity of the lytic origin of EBV replication (ori Lyt).@(((:tag . "NNP") (:stem . "R7-57") (:form . "R7-57") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "signal") (:form . "signaled") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ori") (:form . "ori") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lyt") (:form . "Lyt") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s240.6) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002172@unknown@formal@none@1@S@Different modes, like chemical induction, lytic superinfection with EBV and single gene trans-activation converted the recombinant ori Lyt element in R7-57 reporter cells.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mode") (:form . "modes") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "chemical") (:form . "chemical") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "superinfection") (:form . "superinfection")\n  (:end . 62) (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 104) (:start . 88) (:id . 56))\n ((:tag . "VBD") (:stem . "convert") (:form . "converted") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "ori") (:form . "ori") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lyt") (:form . "Lyt") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 146)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "r7-57") (:form . "R7-57") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s240.7) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002173@unknown@formal@none@1@S@BZLF 1, transiently expressed in R7-57 reporter cells, was the only EBV trans-activator found, sufficient in inducing the viral lytic cycle.@(((:tag . "NNP") (:stem . "BZLF") (:form . "BZLF") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 19)\n  (:start . 8) (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "r7-57") (:form . "R7-57") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 87) (:start . 72) (:id . 56))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s240.8) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002174@unknown@formal@none@1@S@Basing on these experiments, trans-cellular activation of EBV was tested by cocultivation of BZLF 1-expressing R59Z activator cells with the R7-57 reporter line.@(((:tag . "VBG") (:stem . "base") (:form . "Basing") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "trans-cellular") (:form . "trans-cellular")\n  (:end . 43) (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 72) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cocultivation") (:form . "cocultivation")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BZLF") (:form . "BZLF") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "1-expressing") (:form . "1-expressing") (:end . 110)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "R59Z") (:form . "R59Z") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "R7-57") (:form . "R7-57") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 160) (:start . 156)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s240.9) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002175@unknown@formal@none@1@S@No lytic effect on the reporter cells could be measured, neither by cocultivation of activator cells nor by coincubation of BZLF 1-containing cell lysates.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cocultivation") (:form . "cocultivation")\n  (:end . 81) (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "coincubation") (:form . "coincubation") (:end . 120)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BZLF") (:form . "BZLF") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "1-containing") (:form . "1-containing") (:end . 141)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x240.10.1) (:span 57 64 101 104))\n  ((:id . :x240.10.3) (:span 0 2)))\n (:nscopes ((:id . :x240.10.1) (:span 57 154))\n  ((:id . :x240.10.3) (:span 0 154)))\n (:identifiers (:sid . :s240.10) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002176@unknown@formal@none@1@S@Latency breaking activity, however, was transferred from activator to reporter cells when active, exogenous virus was added.@(((:tag . "NNP") (:stem . "Latency") (:form . "Latency") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "breaking") (:form . "breaking") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transfer") (:form . "transferred") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 123) (:start . 118)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s240.11) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002177@unknown@formal@none@1@S@The cell system described in these experiments provides a tool for the detection of EBV reactivation and demonstrates the potential of the lytic regulatory gene BZLF 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 117)\n  (:start . 105) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 155)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BZLF") (:form . "BZLF") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s240.12) (:did . :|93228445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002178@unknown@formal@none@1@S@Immobilization and recovery of fusion proteins and B-lymphocyte cells using magnetic separation.@(((:tag . "NN") (:stem . "immobilization") (:form . "Immobilization")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "b-lymphocyte") (:form . "B-lymphocyte") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "magnetic") (:form . "magnetic") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s241.1) (:did . :|93228833|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5002181@unknown@formal@none@1@S@The results show for the first time that a DNA-binding protein can be used for affinity purification of fusion proteins as exemplified by the specific and gentle recovery of beta-galactosidase and alkaline phosphatase from bacterial lysates using immunomagnetic separation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 100)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "exemplify") (:form . "exemplified") (:end . 134)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 150)\n  (:start . 142) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "gentle") (:form . "gentle") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "beta-galactosidase") (:form . "beta-galactosidase")\n  (:end . 192) (:start . 174) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "alkaline") (:form . "alkaline") (:end . 205)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 217)\n  (:start . 206) (:id . 74))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 222) (:start . 218)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 232)\n  (:start . 223) (:id . 76))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 240)\n  (:start . 233) (:id . 77))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 246) (:start . 241)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "immunomagnetic") (:form . "immunomagnetic")\n  (:end . 261) (:start . 247) (:id . 79))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 272)\n  (:start . 262) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s241.4) (:did . :|93228833|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002182@unknown@formal@none@1@S@The approach was further extended to cell separation by the efficient recovery and elution of human CD37 B lymphocytes from peripheral blood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBN") (:stem . "extend") (:form . "extended") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "elution") (:form . "elution") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD37") (:form . "CD37") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 118)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s241.5) (:did . :|93228833|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002183@unknown@formal@none@1@S@Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.@(((:tag . "JJ") (:stem . "negative") (:form . "Negative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 35)\n  (:start . 25) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 56)\n  (:start . 45) (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 58) (:start . 57)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 89) (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 110)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 145)\n  (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 150) (:start . 146)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 160)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s242.1) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002184@unknown@formal@none@1@S@IL-2 gene transcription is affected by several nuclear proteins.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s242.2) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002185@unknown@formal@none@1@S@We asked whether dexamethasone (Dex) and cyclosporin A (CsA) inhibit IL-2 gene transcription by interfering with the activity of nuclear proteins that bind to the IL-2 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "ask") (:form . "asked") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Dex") (:form . "Dex") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 68)\n  (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 107)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 176)\n  (:start . 168) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x242.3.1) (:span 9 16)))\n (:hscopes ((:id . :x242.3.1) (:span 9 176)))\n (:identifiers (:sid . :s242.3) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002186@unknown@formal@none@1@S@Nuclear extracts from primary human T lymphocytes were analyzed by electrophoretic DNA mobility shift assays.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 82) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s242.4) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002187@unknown@formal@none@1@S@Both Dex and CsA inhibited the binding of transcription factors AP-1 and NF-AT, but not of NF-kB and OCT-1/OAF, to their corresponding sites on the IL-2 gene promoter.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Dex") (:form . "Dex") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "OCT-1/OAF") (:form . "OCT-1/OAF") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 134)\n  (:start . 121) (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 166)\n  (:start . 158) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x242.5.1) (:span 84 87)))\n (:nscopes ((:id . :x242.5.1) (:span 84 110)))\n (:identifiers (:sid . :s242.5) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002188@unknown@formal@none@1@S@To correlate changes in nuclear factor binding in vitro with transcriptional activity in vivo and define the structural requirements for IL-2 promoter repression, we used transient DNA transfections.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 76) (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 132)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 161)\n  (:start . 151) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "transfection") (:form . "transfections")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s242.6) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002190@unknown@formal@none@1@S@Dex inhibited the IL-2 promoter and the AP-1, but not the NF-AT and NF-kB plasmids.@(((:tag . "NNP") (:stem . "Dex") (:form . "Dex") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x242.8.1) (:span 50 53)))\n (:nscopes ((:id . :x242.8.1) (:span 50 82)))\n (:identifiers (:sid . :s242.8) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002191@unknown@formal@none@1@S@In contrast, CsA inhibited the IL-2 promoter and the NF-AT, but not the AP-1 and NF-kB plasmids.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nf-kb") (:form . "NF-kB") (:end . 86) (:start . 81)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x242.9.1) (:span 64 67)))\n (:nscopes ((:id . :x242.9.1) (:span 64 95)))\n (:identifiers (:sid . :s242.9) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002192@unknown@formal@none@1@S@These results suggest that in human T lymphocytes both Dex and CsA inhibited IL-2 gene transcription through interference with transcription factors AP-1 and NF-AT.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Dex") (:form . "Dex") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x242.10.1) (:span 14 21)))\n (:hscopes ((:id . :x242.10.1) (:span 14 163)))\n (:identifiers (:sid . :s242.10) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002193@unknown@formal@none@1@S@We propose that, while maximum inhibition may involve interaction with both transcription factors, AP-1 is the primary target of Dex.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Dex") (:form . "Dex") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x242.11.1) (:span 42 45)) ((:id . :x242.11.2) (:span 3 10)))\n (:hscopes ((:id . :x242.11.1) (:span 42 97))\n  ((:id . :x242.11.2) (:span 3 132)))\n (:identifiers (:sid . :s242.11) (:did . :|93232271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002194@unknown@formal@none@1@S@Lymphocytes from the site of disease suggest adenovirus is one cause of persistent or recurrent inflammatory arthritis.@(((:tag . "NNS") (:stem . "lymphocyte") (:form . "Lymphocytes") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 108)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x243.1.1) (:span 37 44)))\n (:hscopes ((:id . :x243.1.1) (:span 37 118)))\n (:identifiers (:sid . :s243.1) (:did . :|93233083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002195@unknown@formal@none@1@S@The assessment of synovial lymphocyte reactivity to adenovirus antigen stimulation was undertaken in patients with persistent or recurrent inflammatory arthritis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "assessment") (:form . "assessment") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 82)\n  (:start . 71) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "undertake") (:form . "undertaken") (:end . 97)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 125)\n  (:start . 115) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 138)\n  (:start . 129) (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 151)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 161)\n  (:start . 152) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s243.2) (:did . :|93233083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002196@unknown@formal@none@1@S@The 3H-thymidine uptake procedure was employed, incorporating multiple microbiological antigens.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "3H-thymidine") (:form . "3H-thymidine") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "incorporate") (:form . "incorporating") (:end . 61)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "microbiological") (:form . "microbiological")\n  (:end . 86) (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 95)\n  (:start . 87) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s243.3) (:did . :|93233083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002197@unknown@formal@none@1@S@Five patients were found with repeated maximal responses to adenovirus antigen; in one of these adenovirus nucleotide sequences were present in a synovial biopsy specimen.@(((:tag . "CD") (:stem . "five") (:form . "Five") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "biopsy") (:form . "biopsy") (:end . 161)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "specimen") (:form . "specimen") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s243.4) (:did . :|93233083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002198@unknown@formal@none@1@S@It is concluded that adenovirus may be one cause of persistent or recurrent inflammatory arthritis.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 88)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x243.5.1) (:span 32 35)))\n (:hscopes ((:id . :x243.5.1) (:span 32 98)))\n (:identifiers (:sid . :s243.5) (:did . :|93233083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002200@unknown@formal@none@1@S@In this study we analyzed the T cell receptor(TcR) delta transcripts expressed by CD3-CD16+ cells and we investigated whether these cells expressed the hGATA-3 T cell transcription factor and the recombination-activating gene ( RAG ) -1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "receptor(TcR)") (:form . "receptor(TcR)")\n  (:end . 50) (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd3-cd16+") (:form . "CD3-CD16+") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 117)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 180) (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 187)\n  (:start . 181) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "recombination-activating")\n  (:form . "recombination-activating") (:end . 220) (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 225) (:start . 221)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "RAG") (:form . "RAG") (:end . 231) (:start . 228)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 76))\n ((:tag . "CD") (:stem . "-1") (:form . "-1") (:end . 236) (:start . 234)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x244.2.1) (:span 118 125)))\n (:hscopes ((:id . :x244.2.1) (:span 118 236)))\n (:identifiers (:sid . :s244.2) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002201@unknown@formal@none@1@S@Multiple TcR delta transcripts deriving from an unrearranged TcR delta gene were detected in both polyclonal and clonal CD3-CD16+ natural killer(NK) cell lines.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBG") (:stem . "derive") (:form . "deriving") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "cd3-cd16+") (:form . "CD3-CD16+") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "JJ") (:stem . "killer(NK)") (:form . "killer(NK)") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s244.3) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002202@unknown@formal@none@1@S@Two unrearranged TcR delta transcripts had a size similar to that of the functional TcR delta mRNA (2.3 and 1.3 kb) found in TcR gamma/delta+ T lymphocytes.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "CD") (:stem . "2.3") (:form . "2.3") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1.3") (:form . "1.3") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 121)\n  (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 128) (:start . 125)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "gamma/delta+") (:form . "gamma/delta+")\n  (:end . 141) (:start . 129) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 143) (:start . 142)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 155)\n  (:start . 144) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s244.4) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002203@unknown@formal@none@1@S@Sequence analysis of nine different 2.3-kb cDNA clones obtained from NK-derived polyA+ RNA confirmed that they corresponded to an unrearranged TcR delta gene.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "2.3-kb") (:form . "2.3-kb") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nk-derived") (:form . "NK-derived") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "polya+") (:form . "polyA+") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "correspond") (:form . "corresponded") (:end . 123)\n  (:start . 111) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 142)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s244.5) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002204@unknown@formal@none@1@S@These cDNA were 2343 bp long and their transcription initiation site was located 814 bp upstream from the J delta 1 segment.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "2343") (:form . "2343") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 38)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "CD") (:stem . "814") (:form . "814") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s244.6) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002205@unknown@formal@none@1@S@The sequence located upstream of the J delta 1 segment corresponded to the previously reported germ-line sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "VBD") (:stem . "correspond") (:form . "corresponded") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "germ-line") (:form . "germ-line") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s244.7) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002206@unknown@formal@none@1@S@The J delta 1 segment was correctly spliced to C delta; in addition the four C delta exons were found to be already assembled.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "correctly") (:form . "correctly") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "VBN") (:stem . "splice") (:form . "spliced") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 67)\n  (:start . 59) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 78) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 84) (:start . 79)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 101) (:start . 96)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 64))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 115)\n  (:start . 108) (:id . 65))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 125)\n  (:start . 116) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s244.8) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002207@unknown@formal@none@1@S@Two polyadenylation sites were present in the fourth C delta exon.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "polyadenylation") (:form . "polyadenylation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fourth") (:form . "fourth") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s244.9) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002208@unknown@formal@none@1@S@However, only that located at the 3' end appeared to be utilized in the 2.3-kb cDNA.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 49)\n  (:start . 41) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 64)\n  (:start . 56) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "2.3-kb") (:form . "2.3-kb") (:end . 78)\n  (:start . 72) (:id . 58))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x244.10.1) (:span 41 49)))\n (:hscopes ((:id . :x244.10.1) (:span 9 83)))\n (:identifiers (:sid . :s244.10) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002210@unknown@formal@none@1@S@All NK clones and cell lines studied were found to express hGATA-3-specific mRNA, suggesting that hGATA-3 may be involved in the regulation of the unrearranged TcR delta gene expression in NK cells.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "JJ") (:stem . "hgata-3-specific") (:form . "hGATA-3-specific")\n  (:end . 75) (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 159)\n  (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 185)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x244.12.1) (:span 106 109))\n  ((:id . :x244.12.2) (:span 82 92)))\n (:hscopes ((:id . :x244.12.1) (:span 106 197))\n  ((:id . :x244.12.2) (:span 82 197)))\n (:identifiers (:sid . :s244.12) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002211@unknown@formal@none@1@S@Finally, no transcription of the RAG-1 gene could be detected in all NK cell lines or clones analyzed.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rag-1") (:form . "RAG-1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x244.13.1) (:span 9 11)))\n (:nscopes ((:id . :x244.13.1) (:span 9 101)))\n (:identifiers (:sid . :s244.13) (:did . :|93238864|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002212@unknown@formal@none@1@S@Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene.@(((:tag . "JJ") (:stem . "cell-specific") (:form . "Cell-specific")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 44) (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 47))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 74)\n  (:start . 67) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 85) (:start . 82)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s245.1) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002213@unknown@formal@none@1@S@The E2A gene encodes transcription factors of the helix-loop-helix family that are implicated in cell-specific gene expression as part of dimeric complexes that interact with E box enhancer elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 66) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 110) (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dimeric") (:form . "dimeric") (:end . 145)\n  (:start . 138) (:id . 62))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 155)\n  (:start . 146) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 169)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 66))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 189)\n  (:start . 181) (:id . 69))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 198)\n  (:start . 190) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s245.2) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002214@unknown@formal@none@1@S@It has previously been shown that transcripts of the E2A gene can be detected in a wide range of cell types.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 107)\n  (:start . 102) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s245.3) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002215@unknown@formal@none@1@S@We have now examined expression of the mouse E2A gene at the protein level using polyclonal antisera directed against distinct portions of the E2A protein to probe blots of cellular extracts.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "NNS") (:stem . "antiserum") (:form . "antisera") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s245.4) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002216@unknown@formal@none@1@S@A 73 kDa protein was identified by this analysis:@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "73") (:form . "73") (:end . 4) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s245.5) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002217@unknown@formal@none@1@S@this protein is highly enriched in cell lines of B lymphoid origin as compared to pancreatic beta-cells and fibroblast cells.@(((:tag . "DT") (:stem . "this") (:form . "this") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "beta-cell") (:form . "beta-cells") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s245.6) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002218@unknown@formal@none@1@S@The detection of this protein selectively in extracts of lymphoid cells correlates with the presence of the E box-binding activity LEF1/BCF1 in these cells;@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "box-binding") (:form . "box-binding") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "lef1/bcf1") (:form . "LEF1/BCF1") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s245.7) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002220@unknown@formal@none@1@S@Transfection of cells with full length E2A cDNA leads to appearance of protein co-migrating with the 73 kDa protein on SDS gel electrophoresis and co-migrating with LEF1/BCF1 on mobility shift analysis.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "VBG") (:stem . "co-migrate") (:form . "co-migrating") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "CD") (:stem . "73") (:form . "73") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SDS") (:form . "SDS") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 142) (:start . 127) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "co-migrate") (:form . "co-migrating") (:end . 159)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lef1/bcf1") (:form . "LEF1/BCF1") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 192)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 201)\n  (:start . 193) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s245.9) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002221@unknown@formal@none@1@S@Our results are consistent with the view that the DNA-binding activity LEF1/BCF1 is a homodimer of E2A proteins;@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "lef1/bcf1") (:form . "LEF1/BCF1") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s245.10) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002222@unknown@formal@none@1@S@the selective appearance of this putative cell-specific transcription factor in B lymphoid cells seems to be attributable, at least in part, to the elevated E2A protein concentrations in these cells.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 55) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 121)\n  (:start . 109) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 183) (:start . 169) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 192)\n  (:start . 187) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 198)\n  (:start . 193) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x245.11.2) (:span 97 102))\n  ((:id . :x245.11.1) (:span 33 41)))\n (:hscopes ((:id . :x245.11.1) (:span 33 76))\n  ((:id . :x245.11.2) (:span 0 198)))\n (:identifiers (:sid . :s245.11) (:did . :|93241941|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002223@unknown@formal@none@1@S@HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s246.1) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002224@unknown@formal@none@1@S@The human immunodeficiency virus type 1 long terminal repeat, HIV-1-LTR, contains binding sites for several cellular transcription factors which contribute to HIV-1 gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 26) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1-LTR") (:form . "HIV-1-LTR") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s246.2) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002225@unknown@formal@none@1@S@Our previous studies on the function of the HIV-1-encoded Nef protein suggested that Nef may be an inhibitor HIV-1 transcription.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hiv-1-encoded") (:form . "HIV-1-encoded")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "nef") (:form . "Nef") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x246.3.1) (:span 89 92)) ((:id . :x246.3.2) (:span 70 79)))\n (:hscopes ((:id . :x246.3.1) (:span 89 128))\n  ((:id . :x246.3.2) (:span 70 128)))\n (:identifiers (:sid . :s246.3) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002226@unknown@formal@none@1@S@To determine whether Nef affects the binding of cellular factors implicated in HIV-1 regulation, 32P-labeled oligonucleotides corresponding to the binding sites were incubated with nuclear extracts prepared from Nef-expressing T-cell lines that were not stimulated or were stimulated with T-cell mitogens.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "32p-labeled") (:form . "32P-labeled") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 125) (:start . 109) (:id . 58))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 139)\n  (:start . 126) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 154)\n  (:start . 147) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 160)\n  (:start . 155) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 175)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 188)\n  (:start . 181) (:id . 67))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 197)\n  (:start . 189) (:id . 68))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 206)\n  (:start . 198) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 211) (:start . 207)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nef-expressing") (:form . "Nef-expressing")\n  (:end . 226) (:start . 212) (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 233)\n  (:start . 227) (:id . 72))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 239)\n  (:start . 234) (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 244) (:start . 240)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 249) (:start . 245)\n  (:id . 75))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 253) (:start . 250)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 264)\n  (:start . 254) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 267) (:start . 265)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 272) (:start . 268)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 283)\n  (:start . 273) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 288) (:start . 284)\n  (:id . 81))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 295)\n  (:start . 289) (:id . 82))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 304)\n  (:start . 296) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x246.4.2) (:span 265 267))\n  ((:id . :x246.4.3) (:span 13 20)))\n (:ncues ((:id . :x246.4.1) (:span 250 253)))\n (:hscopes ((:id . :x246.4.2) (:span 245 264))\n  ((:id . :x246.4.3) (:span 13 95)))\n (:nscopes ((:id . :x246.4.1) (:span 245 304)))\n (:identifiers (:sid . :s246.4) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002227@unknown@formal@none@1@S@We found that Nef inhibited the recruitment of AP-1 DNA-binding activity in mitogen-stimulated human T-cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mitogen-stimulated") (:form . "mitogen-stimulated")\n  (:end . 94) (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s246.5) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002228@unknown@formal@none@1@S@Additionally, Nef expressing cells were transiently transfected with a plasmid in which HIV-1 AP-1 DNA recognition sequences were cloned downstream of the chloramphenicol acetyltransferase (CAT) gene.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expressing") (:form . "expressing") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 170) (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 188) (:start . 171) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 190) (:start . 189)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 193) (:start . 190)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s246.6) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002230@unknown@formal@none@1@S@These studies suggest that, by inhibiting AP-1 activation, Nef may play a role in regulating HIV-1 gene expression in infected T-cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x246.8.1) (:span 63 66)) ((:id . :x246.8.2) (:span 14 21)))\n (:hscopes ((:id . :x246.8.1) (:span 63 134))\n  ((:id . :x246.8.2) (:span 14 134)))\n (:identifiers (:sid . :s246.8) (:did . :|93242763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002231@unknown@formal@none@1@S@Hypertension in pregnancy.@(((:tag . "NN") (:stem . "hypertension") (:form . "Hypertension") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pregnancy") (:form . "pregnancy") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 26) (:start . 25)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s247.1) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002232@unknown@formal@none@1@S@Pregnancy-induced hypertension (PIH) is a frequent cause of maternal and neonatal morbidity and mortality.@(((:tag . "JJ") (:stem . "pregnancy-induced") (:form . "Pregnancy-induced")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 30)\n  (:start . 18) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "maternal") (:form . "maternal") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "morbidity") (:form . "morbidity") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mortality") (:form . "mortality") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s247.2) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002233@unknown@formal@none@1@S@In the present study we focused on the pathophysiology of PIH, mainly on the role of mineralocorticoids, reversed blood pressure patterns, and the resulting necessity of continuous monitoring of the preeclamptic mother.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "focus") (:form . "focused") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 54) (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 103) (:start . 85) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "reverse") (:form . "reversed") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "pressure") (:form . "pressure") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "necessity") (:form . "necessity") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 180)\n  (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "monitoring") (:form . "monitoring") (:end . 191)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "preeclamptic") (:form . "preeclamptic") (:end . 211)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "mother") (:form . "mother") (:end . 218)\n  (:start . 212) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s247.3) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002234@unknown@formal@none@1@S@Problems of antihypertensive therapy are discussed and the first results of a pilot study with Urapidil are presented.@(((:tag . "NNS") (:stem . "problem") (:form . "Problems") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "antihypertensive") (:form . "antihypertensive")\n  (:end . 28) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pilot") (:form . "pilot") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Urapidil") (:form . "Urapidil") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s247.4) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002235@unknown@formal@none@1@S@To examine the role of mineralocorticoids in the pathophysiology of PIH, we studied plasma aldosterone and 18-hydroxy-corticosterone (18-OH-B) levels in 25 women with PIH and in 25 healthy pregnant women.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 41) (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "18-hydroxy-corticosterone")\n  (:form . "18-hydroxy-corticosterone") (:end . 132) (:start . 107)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "18-OH-B") (:form . "18-OH-B") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 180) (:start . 178)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "JJ") (:stem . "pregnant") (:form . "pregnant") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s247.5) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002236@unknown@formal@none@1@S@Furthermore, we evaluated the mineralocorticoid receptor (MR) count in mononuclear leukocytes in the 2 groups.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 47) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MR") (:form . "MR") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "count") (:form . "count") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s247.6) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002237@unknown@formal@none@1@S@The MR-count was significantly decreased in the PIH-group.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MR-count") (:form . "MR-count") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PIH-group") (:form . "PIH-group") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s247.7) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002238@unknown@formal@none@1@S@The values of plasma aldosterone and 18-OH-B were also low.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "18-OH-B") (:form . "18-OH-B") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s247.8) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002240@unknown@formal@none@1@S@Perhaps deoxycorticosterone or a hitherto unknown mineralocorticoid is responsible for the hypertension and altered MR-status.@(((:tag . "RB") (:stem . "perhaps") (:form . "Perhaps") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deoxycorticosterone")\n  (:form . "deoxycorticosterone") (:end . 27) (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "RB") (:stem . "hitherto") (:form . "hitherto") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 67) (:start . 50) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 82)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 103)\n  (:start . 91) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "alter") (:form . "altered") (:end . 115)\n  (:start . 108) (:id . 55))\n ((:tag . "NNP") (:stem . "MR-status") (:form . "MR-status") (:end . 125)\n  (:start . 116) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x247.10.1) (:span 28 30)) ((:id . :x247.10.2) (:span 0 7)))\n (:hscopes ((:id . :x247.10.1) (:span 8 67))\n  ((:id . :x247.10.2) (:span 0 125)))\n (:identifiers (:sid . :s247.10) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002241@unknown@formal@none@1@S@The first results of continuous blood pressure measurements with a noninvasive, real-time blood pressure monitor (Finapres) are presented.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pressure") (:form . "pressure") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "measurement") (:form . "measurements") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "noninvasive") (:form . "noninvasive") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "real-time") (:form . "real-time") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pressure") (:form . "pressure") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "monitor") (:form . "monitor") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "finapre") (:form . "Finapres") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s247.11) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002242@unknown@formal@none@1@S@The comparison of the obtained values with intraarterial measurements demonstrates a good correlation between the two methods.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intraarterial") (:form . "intraarterial")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "measurement") (:form . "measurements") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 82)\n  (:start . 70) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s247.12) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002243@unknown@formal@none@1@S@We also report on the first experiences with Urapidil in the treatment of hypertension in severe preeclampsia.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "experience") (:form . "experiences") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Urapidil") (:form . "Urapidil") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "preeclampsia") (:form . "preeclampsia") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s247.13) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002244@unknown@formal@none@1@S@The data show that hypertension in preeclamptic women can be treated by Urapidil without side effects or reflex-tachycardia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypertension") (:form . "hypertension") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "preeclamptic") (:form . "preeclamptic") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Urapidil") (:form . "Urapidil") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "side") (:form . "side") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "reflex-tachycardia") (:form . "reflex-tachycardia")\n  (:end . 123) (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x247.14.2) (:span 54 57)))\n (:ncues ((:id . :x247.14.1) (:span 81 88)))\n (:hscopes ((:id . :x247.14.2) (:span 19 123)))\n (:nscopes ((:id . :x247.14.1) (:span 81 123)))\n (:identifiers (:sid . :s247.14) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002245@unknown@formal@none@1@S@Further studies will have to prove if Urapidil is suited for prepartal treatment of PIH as well.@(((:tag . "JJR") (:stem . "far") (:form . "Further") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Urapidil") (:form . "Urapidil") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "suit") (:form . "suited") (:end . 56) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "prepartal") (:form . "prepartal") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PIH") (:form . "PIH") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x247.15.1) (:span 35 37)))\n (:hscopes ((:id . :x247.15.1) (:span 35 95)))\n (:identifiers (:sid . :s247.15) (:did . :|93244226|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002246@unknown@formal@none@1@S@Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids.@(((:tag . "JJ") (:stem . "aldosterone-specific")\n  (:form . "Aldosterone-specific") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 29)\n  (:start . 21) (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 39)\n  (:start . 30) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 49) (:start . 44)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "non-genomic") (:form . "non-genomic") (:end . 61)\n  (:start . 50) (:id . 47))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 69)\n  (:start . 62) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mineralocorticoid") (:form . "mineralocorticoids")\n  (:end . 91) (:start . 73) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s248.1) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002247@unknown@formal@none@1@S@Functional studies in extrarenal, non-epithelial cells such as smooth muscle cells and more recently circulating human lymphocytes have provided increasing evidence that aldosterone produces not only classical genomic effects, but also rapid, non-genomic effects on transmembrane electrolyte movements.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "extrarenal") (:form . "extrarenal") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "non-epithelial") (:form . "non-epithelial")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "smooth") (:form . "smooth") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 181)\n  (:start . 170) (:id . 65))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 190)\n  (:start . 182) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 194) (:start . 191)\n  (:id . 67))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 199) (:start . 195)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 209)\n  (:start . 200) (:id . 69))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 217)\n  (:start . 210) (:id . 70))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 225)\n  (:start . 218) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 230) (:start . 227)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 235) (:start . 231)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 241)\n  (:start . 236) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 242) (:start . 241)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "non-genomic") (:form . "non-genomic") (:end . 254)\n  (:start . 243) (:id . 77))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 262)\n  (:start . 255) (:id . 78))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 265) (:start . 263)\n  (:id . 79))\n ((:tag . "NN") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 279) (:start . 266) (:id . 80))\n ((:tag . "NN") (:stem . "electrolyte") (:form . "electrolyte") (:end . 291)\n  (:start . 280) (:id . 81))\n ((:tag . "NNS") (:stem . "movement") (:form . "movements") (:end . 301)\n  (:start . 292) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s248.2) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002248@unknown@formal@none@1@S@These involve activation of the sodium/proton exchanger of the cell membrane at very low, physiological concentrations of aldosterone with an acute onset within 1-2 min.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sodium/proton") (:form . "sodium/proton")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "exchanger") (:form . "exchanger") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 118) (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 133)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "CD") (:stem . "1-2") (:form . "1-2") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s248.3) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002250@unknown@formal@none@1@S@Such changes clearly can not be explained by genomic mechanisms, which are responsible for later effects than the membrane related rapid responses.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 146)\n  (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x248.5.1) (:span 21 28)))\n (:nscopes ((:id . :x248.5.1) (:span 0 146)))\n (:identifiers (:sid . :s248.5) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002251@unknown@formal@none@1@S@The mechanisms underlying these rapid effects of aldosterone on electrolytes have been extensively studied in human lymphocytes, which thus may represent valuable tools in the delineation of the receptor-effector mechanisms involved.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "electrolyte") (:form . "electrolytes") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 106)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 127)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "JJ") (:stem . "valuable") (:form . "valuable") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "tool") (:form . "tools") (:end . 168)\n  (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "delineation") (:form . "delineation") (:end . 187)\n  (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "receptor-effector") (:form . "receptor-effector")\n  (:end . 212) (:start . 195) (:id . 71))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 223)\n  (:start . 213) (:id . 72))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 232)\n  (:start . 224) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x248.6.1) (:span 140 143)))\n (:hscopes ((:id . :x248.6.1) (:span 140 232)))\n (:identifiers (:sid . :s248.6) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002252@unknown@formal@none@1@S@The unique characteristics of this new pathway for steroid action include its rapid time course, 10,000-fold selectivity for aldosterone over cortisol and the ineffectiveness of spironolactones, classical mineralocorticoid antagonists, as antagonists of the response.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "10,000-fold") (:form . "10,000-fold") (:end . 108)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "selectivity") (:form . "selectivity") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 136)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ineffectiveness") (:form . "ineffectiveness")\n  (:end . 174) (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "spironolactone") (:form . "spironolactones")\n  (:end . 193) (:start . 178) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 204)\n  (:start . 195) (:id . 70))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 222) (:start . 205) (:id . 71))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 234)\n  (:start . 223) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 238) (:start . 236)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 250)\n  (:start . 239) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 253) (:start . 251)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 257) (:start . 254)\n  (:id . 77))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 266)\n  (:start . 258) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s248.7) (:did . :|93246027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002253@unknown@formal@none@1@S@Adenovirus E1A inhibits IFN-induced resistance to cytolysis by natural killer cells.@(((:tag . "NNP") (:stem . "Adenovirus") (:form . "Adenovirus") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "ifn-induced") (:form . "IFN-induced") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytolysis") (:form . "cytolysis") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s249.1) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002254@unknown@formal@none@1@S@Infection of target cells with cytopathic viruses inhibits IFN induction of cytolytic resistance to NK cell-mediated cytolysis [IFN-mediated cytoprotection (IFN-MCP)].@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytopathic") (:form . "cytopathic") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytolytic") (:form . "cytolytic") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "cytolysis") (:form . "cytolysis") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ifn-mediated") (:form . "IFN-mediated") (:end . 140)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "cytoprotection") (:form . "cytoprotection")\n  (:end . 155) (:start . 141) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 164)\n  (:start . 157) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s249.2) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002255@unknown@formal@none@1@S@It has been thought that the virally induced inhibition of IFN-MCP is secondary to the shutdown of cellular macromolecular synthesis that accompanies cytopathic virus infections.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "virally") (:form . "virally") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "shutdown") (:form . "shutdown") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "JJ") (:stem . "macromolecular") (:form . "macromolecular")\n  (:end . 122) (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "accompany") (:form . "accompanies") (:end . 149)\n  (:start . 138) (:id . 63))\n ((:tag . "JJ") (:stem . "cytopathic") (:form . "cytopathic") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 177)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x249.3.1) (:span 12 19)))\n (:hscopes ((:id . :x249.3.1) (:span 12 177)))\n (:identifiers (:sid . :s249.3) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002256@unknown@formal@none@1@S@Group C , adenovirus serotype 5 (Ad5) infection inhibits both IFN-MCP and cellular protein synthesis.@(((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "serotype") (:form . "serotype") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ad5") (:form . "Ad5") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s249.4) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002257@unknown@formal@none@1@S@This study determined if the Ad5-induced inhibition of IFN-MCP was independent of adenovirus (Ad) infection and secondary only to the expression of the Ad early region 1A gene (E1A).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ad5-induced") (:form . "Ad5-induced") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ad") (:form . "Ad") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ad") (:form . "Ad") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x249.5.1) (:span 22 24)))\n (:hscopes ((:id . :x249.5.1) (:span 22 181)))\n (:identifiers (:sid . :s249.5) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002258@unknown@formal@none@1@S@To test this hypothesis, 4-h NK cytolysis assays were performed on IFN-gamma-treated human cells infected with an Ad5 E1A deletion mutant, dl343, or transfected with the Ad5 E1A gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "4-h") (:form . "4-h") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytolysis") (:form . "cytolysis") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ifn-gamma-treated") (:form . "IFN-gamma-treated")\n  (:end . 84) (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Ad5") (:form . "Ad5") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dl343") (:form . "dl343") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 160)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Ad5") (:form . "Ad5") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s249.6) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002260@unknown@formal@none@1@S@In contrast to E1A-negative, parental cell lines, IFN-MCP was blocked in Ad5 E1A-transfected epithelial and fibroblastic cell lines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "e1a-negative") (:form . "E1A-negative") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ad5") (:form . "Ad5") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "e1a-transfected") (:form . "E1A-transfected")\n  (:end . 92) (:start . 77) (:id . 56))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "fibroblastic") (:form . "fibroblastic") (:end . 120)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s249.8) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002261@unknown@formal@none@1@S@Genetic mapping studies within the E1A gene demonstrated that expression of only the first exon of E1A was sufficient to inhibit IFN-MCP.@(((:tag . "JJ") (:stem . "genetic") (:form . "Genetic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s249.9) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002262@unknown@formal@none@1@S@DNA sequence homology of E1A genes between different Ad groups (group A, Ad12; group C, Ad5) is limited almost entirely to three conserved regions located within the first exon of E1A.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "ad") (:form . "Ad") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ad12") (:form . "Ad12") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Ad5") (:form . "Ad5") (:end . 91) (:start . 88)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 103)\n  (:start . 96) (:id . 64))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 110)\n  (:start . 104) (:id . 65))\n ((:tag . "RB") (:stem . "entirely") (:form . "entirely") (:end . 119)\n  (:start . 111) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 67))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 128)\n  (:start . 123) (:id . 68))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 138)\n  (:start . 129) (:id . 69))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 146)\n  (:start . 139) (:id . 70))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 154)\n  (:start . 147) (:id . 71))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 161)\n  (:start . 155) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 171)\n  (:start . 166) (:id . 74))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 176) (:start . 172)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 183) (:start . 180)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s249.10) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002263@unknown@formal@none@1@S@Because IFN-MCP was also blocked in Ad12 E1A-transfected cell lines, expression of one or more of the E1A-conserved regions may be necessary to inhibit IFN-MCP.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ad12") (:form . "Ad12") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "e1a-transfected") (:form . "E1A-transfected")\n  (:end . 56) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "e1a-conserved") (:form . "E1A-conserved")\n  (:end . 115) (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x249.11.1) (:span 124 127)))\n (:hscopes ((:id . :x249.11.1) (:span 124 159)))\n (:identifiers (:sid . :s249.11) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002264@unknown@formal@none@1@S@In summary, the expression of E1A gene products inhibited IFN-MCP independently of virus infection.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 79) (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s249.12) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002265@unknown@formal@none@1@S@E1A's inhibition of IFN-MCP has the net effect of promoting the selective NK cell-mediated clearance of Ad-infected or Ad-transformed human cells.@(((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-MCP") (:form . "IFN-MCP") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "net") (:form . "net") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ad-infected") (:form . "Ad-infected") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ad-transformed") (:form . "Ad-transformed")\n  (:end . 133) (:start . 119) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s249.13) (:did . :|93246644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002266@unknown@formal@none@1@S@A chimeric type II / type I interleukin-1 receptor can mediate interleukin-1 induction of gene expression in T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "/") (:form . "/") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 41) (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 76) (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s250.1) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002267@unknown@formal@none@1@S@The type I interleukin-1 receptor (IL-1R) is capable of transducing a signal resulting in promoter activation in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 24) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-1R") (:form . "IL-1R") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "transduce") (:form . "transducing") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s250.2) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002268@unknown@formal@none@1@S@This signal transduction is dependent on the cytoplasmic domain, which consists of 213 amino acids.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "213") (:form . "213") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s250.3) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002270@unknown@formal@none@1@S@Here we report that the type II IL-1R does not mediate gene activation in Jurkat cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-1R") (:form . "IL-1R") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x250.5.1) (:span 43 46)))\n (:nscopes ((:id . :x250.5.1) (:span 43 86)))\n (:identifiers (:sid . :s250.5) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002271@unknown@formal@none@1@S@However, a hybrid receptor composed of the extracellular and transmembrane regions of the human type II interleukin-1 fused to the cytoplasmic domain of the human type I IL-1R was capable of transducing a signal across the membrane resulting in a pattern of gene activation identical to that mediated by the type I IL-1R.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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"to") (:end . 286) (:start . 284)\n  (:id . 88))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 291) (:start . 287)\n  (:id . 89))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 300)\n  (:start . 292) (:id . 90))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 303) (:start . 301)\n  (:id . 91))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 307) (:start . 304)\n  (:id . 92))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 312) (:start . 308)\n  (:id . 93))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 314) (:start . 313)\n  (:id . 94))\n ((:tag . "NN") (:stem . "il-1r") (:form . "IL-1R") (:end . 320)\n  (:start . 315) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 321) (:start . 320)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s250.6) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002272@unknown@formal@none@1@S@Our results indicated that the extracellular domain of the type II IL-1R was capable of functionally interacting with interleukin-1 and transmitting the resulting signal to a heterologous cytoplasmic domain.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-1R") (:form . "IL-1R") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "transmit") (:form . "transmitting") (:end . 148)\n  (:start . 136) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 162)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 169)\n  (:start . 163) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 187)\n  (:start . 175) (:id . 68))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 199)\n  (:start . 188) (:id . 69))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 206)\n  (:start . 200) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x250.7.1) (:span 12 26)))\n (:hscopes ((:id . :x250.7.1) (:span 12 206)))\n (:identifiers (:sid . :s250.7) (:did . :|93252936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002273@unknown@formal@none@1@S@A mutation of the glucocorticoid receptor in primary cortisol resistance.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s251.1) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002274@unknown@formal@none@1@S@The precise molecular abnormalities that cause primary cortisol resistance have not been completely described.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 35)\n  (:start . 22) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x251.2.1) (:span 80 83)))\n (:nscopes ((:id . :x251.2.1) (:span 0 109)))\n (:identifiers (:sid . :s251.2) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002275@unknown@formal@none@1@S@In a subject with primary cortisol resistance we have observed glucocorticoid receptors (hGR) with a decreased affinity for dexamethasone.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "subject") (:form . "subject") (:end . 12)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 137) (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s251.3) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002276@unknown@formal@none@1@S@We hypothesize that a mutation of the hGR glucocorticoid-binding domain is the cause of cortisol resistance.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "hypothesize") (:form . "hypothesize") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "glucocorticoid-binding")\n  (:form . "glucocorticoid-binding") (:end . 64) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s251.4) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002277@unknown@formal@none@1@S@Total RNA isolated from the index subject 's mononuclear leukocytes was used to produce first strand hGR cDNAs, and the entire hGR cDNA was amplified in segments and sequenced.@(((:tag . "JJ") (:stem . "total") (:form . "Total") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "index") (:form . "index") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subject") (:form . "subject") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 175)\n  (:start . 166) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s251.5) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002278@unknown@formal@none@1@S@At nucleotide 2,317 we identified a homozygous A for G point mutation that predicts an isoleucine (ATT) for valine ( GTT ) substitution at amino acid 729.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "CD") (:stem . "2,317") (:form . "2,317") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "isoleucine") (:form . "isoleucine") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "ATT") (:form . "ATT") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "valine") (:form . "valine") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GTT") (:form . "GTT") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 135)\n  (:start . 123) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 149) (:start . 145)\n  (:id . 69))\n ((:tag . "CD") (:stem . "729") (:form . "729") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x251.6.1) (:span 75 83)))\n (:hscopes ((:id . :x251.6.1) (:span 75 153)))\n (:identifiers (:sid . :s251.6) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002280@unknown@formal@none@1@S@When the wild-type hGR and hGR-Ile 729 were expressed in CV-1 cells that were cotransfected with the mouse mammary tumor virus long terminal repeat fused to the chloramphenicol acetyl transferase (CAT) gene, the hGR-Ile 729 conferred a fourfold decrease in apparent potency on dexamethasone stimulation of CAT activity.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hgr-ile") (:form . "hGR-Ile") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "729") (:form . 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"hGR-Ile") (:end . 219)\n  (:start . 212) (:id . 78))\n ((:tag . "CD") (:stem . "729") (:form . "729") (:end . 223) (:start . 220)\n  (:id . 79))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 233)\n  (:start . 224) (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 235) (:start . 234)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "fourfold") (:form . "fourfold") (:end . 244)\n  (:start . 236) (:id . 82))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 253)\n  (:start . 245) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 256) (:start . 254)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 265)\n  (:start . 257) (:id . 85))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 273)\n  (:start . 266) (:id . 86))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 276) (:start . 274)\n  (:id . 87))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 290) (:start . 277) (:id . 88))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 302)\n  (:start . 291) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 305) (:start . 303)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 309) (:start . 306)\n  (:id . 91))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 318)\n  (:start . 310) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 319) (:start . 318)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s251.8) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002281@unknown@formal@none@1@S@The isoleucine for valine substitution at amino acid 729 impairs the function of the hGR and is the likely cause of primary cortisol resistance in this subject.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "isoleucine") (:form . "isoleucine") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "valine") (:form . "valine") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "729") (:form . "729") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "hGR") (:form . "hGR") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "subject") (:form . "subject") (:end . 159)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x251.9.1) (:span 100 106)))\n (:hscopes ((:id . :x251.9.1) (:span 100 159)))\n (:identifiers (:sid . :s251.9) (:did . :|93253031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002282@unknown@formal@none@1@S@Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.@(((:tag . "NNS") (:stem . "mouse") (:form . "Mice") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endotoxic") (:form . "endotoxic") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "succumb") (:form . "succumb") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "L.") (:form . "L.") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "monocytogene") (:form . "monocytogenes")\n  (:end . 125) (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s252.1) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002283@unknown@formal@none@1@S@The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNFRp55") (:form . "TNFRp55") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNFRp75") (:form . "TNFRp75") (:end . 155)\n  (:start . 148) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s252.2) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002284@unknown@formal@none@1@S@Using gene targeting, we generated a TNFRp55-deficient mouse strain.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "targeting") (:form . "targeting") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tnfrp55-deficient") (:form . "TNFRp55-deficient")\n  (:end . 54) (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s252.3) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002285@unknown@formal@none@1@S@Cells from TNFRp55-/-mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "tnfrp55-/-mutant") (:form . "TNFRp55-/-mutant")\n  (:end . 27) (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tnfrp55") (:form . "TNFRp55") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "tnfrp75") (:form . "TNFRp75") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x252.4.1) (:span 33 37)))\n (:nscopes ((:id . :x252.4.1) (:span 33 59)))\n (:identifiers (:sid . :s252.4) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002286@unknown@formal@none@1@S@Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired.@(((:tag . "NNP") (:stem . "Thymocyte") (:form . "Thymocyte") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "self-reactive") (:form . "self-reactive")\n  (:end . 112) (:start . 99) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 136)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x252.5.1) (:span 87 98)))\n (:ncues ((:id . :x252.5.2) (:span 124 127)))\n (:hscopes ((:id . :x252.5.1) (:span 87 120)))\n (:nscopes ((:id . :x252.5.2) (:span 68 136)))\n (:identifiers (:sid . :s252.5) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002287@unknown@formal@none@1@S@However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-kappa B in T lymphocytes from TNFRp55-deficient mice.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 114)\n  (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tnfrp55-deficient") (:form . "TNFRp55-deficient")\n  (:end . 137) (:start . 120) (:id . 65))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 142)\n  (:start . 138) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s252.6) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002288@unknown@formal@none@1@S@The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNFRp55") (:form . "TNFRp55") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "render") (:form . "renders") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "dosage") (:form . "dosages") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "lipopolysaccharide")\n  (:form . "lipopolysaccharides") (:end . 99) (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "FW") (:stem . "aureus") (:form . "aureus") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "enterotoxin") (:form . "enterotoxin") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s252.7) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002290@unknown@formal@none@1@S@Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tnfr") (:form . "TNFR") (:end . 20) (:start . 16)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 26) (:start . 21)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "decisive") (:form . "decisive") (:end . 37)\n  (:start . 29) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 53))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 54) (:start . 50)\n  (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 56) (:start . 54)\n  (:id . 55))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 64)\n  (:start . 57) (:id . 56))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 72)\n  (:start . 65) (:id . 57))\n ((:tag . "NNS") (:stem . "microorganism") (:form . "microorganisms")\n  (:end . 87) (:start . 73) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 97)\n  (:start . 92) (:id . 60))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 108)\n  (:start . 98) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s252.9) (:did . :|93258811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002291@unknown@formal@none@1@S@Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.@(((:tag . "NNP") (:stem . "Cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 39) (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 98) (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s253.1) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002292@unknown@formal@none@1@S@Early B-cell factor (EBF) was identified previously as a tissue-specific and differentiation stage-specific DNA-binding protein that participates in the regulation of the pre-B and B lymphocyte-specific mb-1 gene.@(((:tag . "JJ") (:stem . "early") (:form . "Early") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 72) (:start . 57) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 92) (:start . 77) (:id . 55))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 107) (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 119)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 132) (:start . 128)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 145)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 163)\n  (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "pre-b") (:form . "pre-B") (:end . 176)\n  (:start . 171) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 182) (:start . 181)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 202) (:start . 183) (:id . 69))\n ((:tag . "NN") (:stem . "mb-1") (:form . "mb-1") (:end . 207) (:start . 203)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 212) (:start . 208)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s253.2) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002293@unknown@formal@none@1@S@Partial amino acid sequences obtained from purified EBF were used to isolate cDNA clones, which by multiple criteria encode EBF.@(((:tag . "JJ") (:stem . "partial") (:form . "Partial") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "ebf") (:form . "EBF") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s253.3) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002294@unknown@formal@none@1@S@The recombinant polypeptide formed sequence-specific complexes with the EBF-binding site in the mb-1 promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 34) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 52) (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 62)\n  (:start . 53) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ebf-binding") (:form . "EBF-binding") (:end . 83)\n  (:start . 72) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 88) (:start . 84)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mb-1") (:form . "mb-1") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s253.4) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002295@unknown@formal@none@1@S@The cDNA hybridized to multiple transcripts in pre-B and B-cell lines, but transcripts were not detected at significant levels in plasmacytoma, T-cell, and nonlymphoid cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "hybridize") (:form . "hybridized") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pre-b") (:form . "pre-B") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 119)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 142)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 167)\n  (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x253.5.1) (:span 92 95)))\n (:nscopes ((:id . :x253.5.1) (:span 75 178)))\n (:identifiers (:sid . :s253.5) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002296@unknown@formal@none@1@S@Expression of recombinant EBF in transfected nonlymphoid cells strongly activated transcription from reporter plasmids containing functional EBF-binding sites.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "ebf") (:form . "EBF") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 81)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 118)\n  (:start . 110) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 129)\n  (:start . 119) (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 140)\n  (:start . 130) (:id . 57))\n ((:tag . "JJ") (:stem . "ebf-binding") (:form . "EBF-binding") (:end . 152)\n  (:start . 141) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 158)\n  (:start . 153) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s253.6) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002297@unknown@formal@none@1@S@Analysis of DNA binding by deletion mutants of EBF identified an amino-terminal cysteine-rich DNA-binding domain lacking obvious sequence similarity to known transcription factors.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 79) (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 112)\n  (:start . 106) (:id . 56))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 137)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 148)\n  (:start . 138) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 157)\n  (:start . 152) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 171) (:start . 158) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 179)\n  (:start . 172) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x253.7.1) (:span 113 120)))\n (:nscopes ((:id . :x253.7.1) (:span 113 179)))\n (:identifiers (:sid . :s253.7) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002298@unknown@formal@none@1@S@DNA-binding assays with cotranslated wild-type and truncated forms of EBF indicated that the protein interacts with its site as a homodimer.@(((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "cotranslate") (:form . "cotranslated") (:end . 36)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "truncated") (:form . "truncated") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 66) (:start . 61)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x253.8.1) (:span 74 88)))\n (:hscopes ((:id . :x253.8.1) (:span 74 139)))\n (:identifiers (:sid . :s253.8) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002300@unknown@formal@none@1@S@Together, these data suggest that EBF represents a novel regulator of B lymphocyte-specific gene expression.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 91) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x253.10.1) (:span 21 28)))\n (:hscopes ((:id . :x253.10.1) (:span 21 107)))\n (:identifiers (:sid . :s253.10) (:did . :|93259462|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002301@unknown@formal@none@1@S@[The trend of molecular biology study on eosinophils]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . "NN") (:stem . "trend") (:form . "trend") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 23)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "biology") (:form . "biology") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 53) (:start . 52)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s254.1) (:did . :|93260875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002302@unknown@formal@none@1@S@Recently, many investigators have been interested in the study on eosinophil biology since genes association with eosinophils such as interleukin-5 or eosinophil granule proteins (EPO, ECP, EDN, MBP, and CLC), were isolated.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "investigator") (:form . "investigators")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "interested") (:form . "interested") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "biology") (:form . "biology") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interleukin-5") (:form . "interleukin-5")\n  (:end . 147) (:start . 134) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 161)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 178)\n  (:start . 170) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "ECP") (:form . "ECP") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "EDN") (:form . "EDN") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "CLC") (:form . "CLC") (:end . 207) (:start . 204)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 214) (:start . 210)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 223)\n  (:start . 215) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s254.2) (:did . :|93260875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002303@unknown@formal@none@1@S@However, the molecular basis for the commitment of progenitors to the eosinophil lineage has not been determined.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x254.3.1) (:span 93 96)))\n (:nscopes ((:id . :x254.3.1) (:span 9 112)))\n (:identifiers (:sid . :s254.3) (:did . :|93260875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002304@unknown@formal@none@1@S@The mechanism by which eosinophil-specific genes encoding primary and secondary granule proteins (e.g. ECP, EDN, EPO, MBP, and CLC) are expressed and regulated during eosinophilopoiesis is also unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "eosinophil-specific")\n  (:form . "eosinophil-specific") (:end . 42) (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ECP") (:form . "ECP") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EDN") (:form . "EDN") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CLC") (:form . "CLC") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 145)\n  (:start . 136) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 159)\n  (:start . 150) (:id . 70))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 166)\n  (:start . 160) (:id . 71))\n ((:tag . "NN") (:stem . "eosinophilopoiesis") (:form . "eosinophilopoiesis")\n  (:end . 185) (:start . 167) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 201)\n  (:start . 194) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s254.4) (:did . :|93260875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002305@unknown@formal@none@1@S@In this paper, I described the characterization of genes encoding eosinophil granule proteins and the mRNA expression of GATA-1 binding transcription factor during eosinophil differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "i") (:form . "I") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "describe") (:form . "described") (:end . 26)\n  (:start . 17) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 47) (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 156)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 174)\n  (:start . 164) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 190) (:start . 175) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s254.5) (:did . :|93260875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002306@unknown@formal@none@1@S@Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "Ets-related") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 89) (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s255.1) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002307@unknown@formal@none@1@S@The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 64) (:start . 50) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s255.2) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002308@unknown@formal@none@1@S@Elf-1 is a lymphoid-specific Ets transcription factor that regulates inducible gene expression during T cell activation.@(((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 28) (:start . 11) (:id . 45))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 101)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s255.3) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002310@unknown@formal@none@1@S@Elf-1 binds exclusively to the underphosphorylated form of Rb and fails to bind to Rb mutants derived from patients with retinoblastoma.@(((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "underphosphorylated")\n  (:form . "underphosphorylated") (:end . 50) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 135) (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s255.5) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002311@unknown@formal@none@1@S@Co-immunoprecipitation experiments demonstrated an association between Elf-1 and Rb in resting normal human T cells.@(((:tag . "NNP") (:stem . "Co-immunoprecipitation")\n  (:form . "Co-immunoprecipitation") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 34)\n  (:start . 23) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 47)\n  (:start . 35) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 45))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 62)\n  (:start . 51) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 70)\n  (:start . 63) (:id . 47))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 76) (:start . 71)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 83) (:start . 81)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 94)\n  (:start . 87) (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 101)\n  (:start . 95) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s255.6) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002312@unknown@formal@none@1@S@After T cell activation, the phosphorylation of Rb results in the release of Elf-1, which is correlated temporally with the activation of Elf-1-mediated transcription.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 44) (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 103)\n  (:start . 93) (:id . 60))\n ((:tag . "RB") (:stem . "temporally") (:form . "temporally") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "elf-1-mediated") (:form . "Elf-1-mediated")\n  (:end . 152) (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 166) (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s255.7) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002313@unknown@formal@none@1@S@Overexpression of a phosphorylation-defective form of Rb inhibited Elf-1-dependent transcription during T cell activation.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "phosphorylation-defective")\n  (:form . "phosphorylation-defective") (:end . 45) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 50) (:start . 46)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "JJ") (:stem . "elf-1-dependent") (:form . "Elf-1-dependent")\n  (:end . 82) (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 103)\n  (:start . 97) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s255.8) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002314@unknown@formal@none@1@S@These results demonstrate that Rb interacts specifically with a lineage-restricted Ets transcription factor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 56)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lineage-restricted") (:form . "lineage-restricted")\n  (:end . 82) (:start . 64) (:id . 51))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s255.9) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002315@unknown@formal@none@1@S@This regulated interaction may be important for the coordination of lineage-specific effector functions such as lymphokine production with cell cycle progression in activated T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "coordination") (:form . "coordination") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 84) (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 103)\n  (:start . 94) (:id . 54))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 108) (:start . 104)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 133)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 161)\n  (:start . 150) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 174)\n  (:start . 165) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 176) (:start . 175)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x255.10.1) (:span 27 30)))\n (:hscopes ((:id . :x255.10.1) (:span 27 182)))\n (:identifiers (:sid . :s255.10) (:did . :|93262492|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002316@unknown@formal@none@1@S@Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 131)\n  (:start . 123) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s256.1) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002317@unknown@formal@none@1@S@Stimulation of highly purified human T-cells via CD2 and CD28 adhesion molecules induces and maintains proliferation for more than 3 weeks.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "maintain") (:form . "maintains") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "week") (:form . "weeks") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s256.2) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002318@unknown@formal@none@1@S@This potent interleukin 2 ( IL-2 ) -dependent activation does not require monocytes or accessory cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "-dependent") (:form . "-dependent") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x256.3.1) (:span 62 65)))\n (:nscopes ((:id . :x256.3.1) (:span 62 102)))\n (:identifiers (:sid . :s256.3) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002320@unknown@formal@none@1@S@Increase of IL-2R alpha gene transcription involves the enhanced binding of the transcription factor NF-kappa B to its consensus sequence in the 5'-regulatory region of the IL-2R alpha gene.@(((:tag . "NN") (:stem . "increase") (:form . "Increase") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "5'-regulatory") (:form . "5'-regulatory")\n  (:end . 158) (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 165)\n  (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 184)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s256.5) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002321@unknown@formal@none@1@S@To dissect the molecular basis for the unusually persistent transcription of the IL-2R alpha gene, we analyzed nuclear NF-kappa B binding to a radiolabeled IL-2R alpha kappa B-specific oligonucleotide probe during the time course of CD2 + CD28 activation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "dissect") (:form . "dissect") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "unusually") (:form . "unusually") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "radiolabele") (:form . "radiolabeled") (:end . 155)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "JJ") (:stem . "b-specific") (:form . "B-specific") (:end . 184)\n  (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 200) (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 206)\n  (:start . 201) (:id . 72))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 213)\n  (:start . 207) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 74))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 222) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 229)\n  (:start . 223) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 236) (:start . 233)\n  (:id . 78))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 238) (:start . 237)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 243) (:start . 239)\n  (:id . 80))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 254)\n  (:start . 244) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s256.6) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002322@unknown@formal@none@1@S@Resting T-cell nuclear extracts contained KBF1/p50 homodimer.@(((:tag . "VBG") (:stem . "rest") (:form . "Resting") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "kbf1/p50") (:form . "KBF1/p50") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s256.7) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002323@unknown@formal@none@1@S@After stimulation, two new kappa B-specific complexes were identified as NF-kappa B p50-p65 heterodimer and putative c-Rel homodimer or c-Rel-p65 heterodimer.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "b-specific") (:form . "B-specific") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-rel-p65") (:form . "c-Rel-p65") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 157)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x256.8.1) (:span 133 135))\n  ((:id . :x256.8.2) (:span 108 116)))\n (:hscopes ((:id . :x256.8.1) (:span 117 157))\n  ((:id . :x256.8.2) (:span 108 157)))\n (:identifiers (:sid . :s256.8) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002324@unknown@formal@none@1@S@Both inducible complexes persisted for at least 3 weeks.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "persist") (:form . "persisted") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "week") (:form . "weeks") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s256.9) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002325@unknown@formal@none@1@S@Their relative levels were very similar for the duration of proliferation.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "duration") (:form . "duration") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 73) (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s256.10) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002326@unknown@formal@none@1@S@In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 48))\n ((:tag . "VBD") (:stem . "trigger") (:form . "triggered") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "radical") (:form . "radicals") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x256.11.1) (:span 89 99)))\n (:hscopes ((:id . :x256.11.1) (:span 89 180)))\n (:identifiers (:sid . :s256.11) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002327@unknown@formal@none@1@S@Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "micromolar") (:form . "micromolar") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 58) (:start . 43) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 166) (:start . 153) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 182)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 187) (:start . 183)\n  (:id . 68))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 197)\n  (:start . 188) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 204)\n  (:start . 199) (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 210)\n  (:start . 205) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 215) (:start . 211)\n  (:id . 73))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 223)\n  (:start . 216) (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 234)\n  (:start . 224) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 77))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 246)\n  (:start . 240) (:id . 78))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 260) (:start . 247) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s256.12) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002328@unknown@formal@none@1@S@Together, these results suggest that NF-kappa B plays an important role in long-term activation of human primary T-lymphocytes via CD2 + CD28.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x256.13.1) (:span 24 31)))\n (:hscopes ((:id . :x256.13.1) (:span 24 141)))\n (:identifiers (:sid . :s256.13) (:did . :|93264305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002330@unknown@formal@none@1@S@Involvement of a cellular reducing catalyst thioredoxin.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "catalyst") (:form . "catalyst") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "thioredoxin") (:form . "thioredoxin") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s257.2) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002331@unknown@formal@none@1@S@We have investigated an oxidoreductive regulatory pathway for the DNA binding activity of a pleiotropic cellular transcription factor, nuclear factor kappa B (NF kappa B), has been investigated by using NF kappa B prepared from the nucleus and the cytosol of the primary human T lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "oxidoreductive") (:form . "oxidoreductive")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . 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5002332@unknown@formal@none@1@S@We show that a cellular reducing catalyst thioredoxin (Trx) plays a major role in activation of the DNA binding of NF kappa B in vitro and stimulation of transcription from the NF kappa B-dependent gene expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "catalyst") (:form . "catalyst") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "thioredoxin") (:form . "thioredoxin") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Trx") (:form . "Trx") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 123)\n  (:start . 118) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 134)\n  (:start . 129) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 150)\n  (:start . 139) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 167) (:start . 154) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 172) (:start . 168)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 179) (:start . 177)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 185)\n  (:start . 180) (:id . 76))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 197)\n  (:start . 186) (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 202) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 213)\n  (:start . 203) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s257.4) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002333@unknown@formal@none@1@S@We demonstrate evidence suggesting that redox regulation of NF kappa B by Trx might be exerted at a step after dissociation of the inhibitory molecule I kappa B, a cytosolic-anchoring protein for NF kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Trx") (:form . "Trx") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 123)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 141)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 150)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cytosolic-anchoring")\n  (:form . "cytosolic-anchoring") (:end . 183) (:start . 164) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 191)\n  (:start . 184) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 198) (:start . 196)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 204)\n  (:start . 199) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x257.5.1) (:span 78 83)) ((:id . :x257.5.2) (:span 24 34)))\n (:hscopes ((:id . :x257.5.1) (:span 78 206))\n  ((:id . :x257.5.2) (:span 24 206)))\n (:identifiers (:sid . :s257.5) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002334@unknown@formal@none@1@S@To examine the effect of Trx in intact cells, we performed transient assay with a chloramphenicol acetyltransferase-expressing plasmid under the control of human immunodeficiency virus (HIV) long terminal repeat and an effector plasmid expressing human Trx.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Trx") (:form . "Trx") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 58)\n  (:start . 49) (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 97) (:start . 82) (:id . 58))\n ((:tag . "JJ") (:stem . "acetyltransferase-expressing")\n  (:form . "acetyltransferase-expressing") (:end . 126) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 178) (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 184)\n  (:start . 179) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 195) (:start . 191)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 211)\n  (:start . 205) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 74))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 227)\n  (:start . 219) (:id . 76))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 235)\n  (:start . 228) (:id . 77))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 246)\n  (:start . 236) (:id . 78))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 252)\n  (:start . 247) (:id . 79))\n ((:tag . "NNP") (:stem . "Trx") (:form . "Trx") (:end . 256) (:start . 253)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s257.6) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002335@unknown@formal@none@1@S@The promoter activity from HIV long terminal repeat was greatly augmented by co-transfecting the Trx-expressing plasmid, whose effect was dependent on the NF kappa B-binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "VBN") (:stem . "augment") (:form . "augmented") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "co-transfecte") (:form . "co-transfecting")\n  (:end . 92) (:start . 77) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "trx-expressing") (:form . "Trx-expressing")\n  (:end . 111) (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 119)\n  (:start . 112) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 58))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 133)\n  (:start . 127) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s257.7) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002336@unknown@formal@none@1@S@These findings have suggested that cysteine residue ( s ) of NF kappa B might be involved in the DNA-recognition by NF kappa B and that the redox control mechanism mediated by Trx might have a regulatory role in the NF kappa B-mediated gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . 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5002337@unknown@formal@none@1@S@These results may also provide a clue to understanding of the molecular process of AIDS pathogenesis and its possible biochemical intervention.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "clue") (:form . "clue") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "intervention") (:form . "intervention") (:end . 142)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x257.9.1) (:span 109 117))\n  ((:id . :x257.9.2) (:span 14 17)))\n (:hscopes ((:id . :x257.9.1) (:span 109 142))\n  ((:id . :x257.9.2) (:span 14 142)))\n (:identifiers (:sid . :s257.9) (:did . :|93266597|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002338@unknown@formal@none@1@S@Expression levels of the thyrotropin receptor gene in autoimmune thyroid disease: coregulation with parameters of thyroid function and inverse relation to major histocompatibility complex classes I and II.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "thyrotropin") (:form . "thyrotropin") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "coregulation") (:form . "coregulation") (:end . 94)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 142)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 179) (:start . 161) (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 187)\n  (:start . 180) (:id . 66))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 195)\n  (:start . 188) (:id . 67))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 197) (:start . 196)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 69))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 204) (:start . 202)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s258.1) (:did . :|93266777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002340@unknown@formal@none@1@S@7 Graves ' disease, 2 Hashimoto 's disease, 3 endemic goiter, and 1 healthy thyroid gland were studied.@(((:tag . "CD") (:stem . "7") (:form . "7") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Graves") (:form . "Graves") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Hashimoto") (:form . "Hashimoto") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endemic") (:form . "endemic") (:end . 53)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "goiter") (:form . "goiter") (:end . 60)\n  (:start . 54) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 67) (:start . 66)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 75)\n  (:start . 68) (:id . 58))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 83)\n  (:start . 76) (:id . 59))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 102)\n  (:start . 95) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s258.3) (:did . :|93266777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002341@unknown@formal@none@1@S@TSH-R expression levels were variable, but displayed a close correlation to the expression of thyroid peroxidase (r = 0.703; P < 0.05), thyroglobulin (r = 0.817; P < 0.01), and the nuclear oncogene c-fos (r = 0.935; P < 0.001), but not c-myc.@(((:tag . "NNP") (:stem . "TSH-R") (:form . "TSH-R") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "display") (:form . 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5002342@unknown@formal@none@1@S@Overall, TSH-R transcript levels were low or absent in those thyroids in which expression of the major histocompatibility complex class I or II (MHC I or II) was high, thus establishing an inverse relation (MHC I, r = -0.791; P < 0.01; MHC II, r = -0.784; P < 0.01).@(((:tag . "RB") (:stem . "overall") (:form . "Overall") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "TSH-R") (:form . "TSH-R") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . 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5002343@unknown@formal@none@1@S@In situ hybridization showed that apart from lymphocytes, thyroid cells themselves were the source of MHC II transcripts.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 28) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "apart") (:form . "apart") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "thyroid") (:form . "thyroid") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "themselves") (:form . "themselves") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s258.6) (:did . :|93266777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002344@unknown@formal@none@1@S@gamma-Interferon expression was only detectable in 1 Hashimoto 's goiter.@(((:tag . "NN") (:stem . "gamma-interferon") (:form . "gamma-Interferon")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 47)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Hashimoto") (:form . "Hashimoto") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "goiter") (:form . "goiter") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s258.7) (:did . :|93266777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002345@unknown@formal@none@1@S@Our findings suggest that next to lymphocyte infiltration, active regulatory events in the thyrocyte are responsible for the inverse relation between functional parameters (TSH-R, thyroid peroxidase, thyroglobulin, and c-fos) and immunological markers (MHC I and II).@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thyrocyte") (:form . "thyrocyte") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 116)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 171)\n  (:start . 161) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TSH-R") (:form . "TSH-R") (:end . 178)\n  (:start . 173) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "peroxidase") (:form . "peroxidase") (:end . 198)\n  (:start . 188) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "thyroglobulin") (:form . "thyroglobulin")\n  (:end . 213) (:start . 200) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 218) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 224)\n  (:start . 219) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 225) (:start . 224)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 229) (:start . 226)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 243) (:start . 230) (:id . 78))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 251)\n  (:start . 244) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 253) (:start . 252)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 256) (:start . 253)\n  (:id . 81))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 258) (:start . 257)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 83))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 265) (:start . 263)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 266) (:start . 265)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x258.8.1) (:span 13 20)))\n (:hscopes ((:id . :x258.8.1) (:span 13 266)))\n (:identifiers (:sid . :s258.8) (:did . :|93266777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002346@unknown@formal@none@1@S@Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mycobacterial") (:form . "mycobacterial")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 104) (:start . 86) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "factor-il6") (:form . "factor-IL6") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s259.1) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002347@unknown@formal@none@1@S@The cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) are released by mononuclear phagocytes in vitro after stimulation with mycobacteria and are considered to mediate pathophysiologic events, including granuloma formation and systemic symptoms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 154)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "mycobacterium") (:form . "mycobacteria")\n  (:end . 172) (:start . 160) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 191)\n  (:start . 181) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . "JJ") (:stem . "pathophysiologic") (:form . "pathophysiologic")\n  (:end . 219) (:start . 203) (:id . 74))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 226)\n  (:start . 220) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 227) (:start . 226)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 237)\n  (:start . 228) (:id . 77))\n ((:tag . "NN") (:stem . "granuloma") (:form . "granuloma") (:end . 247)\n  (:start . 238) (:id . 78))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 257)\n  (:start . 248) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 261) (:start . 258)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 270)\n  (:start . 262) (:id . 81))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 279)\n  (:start . 271) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x259.2.1) (:span 181 191)))\n (:hscopes ((:id . :x259.2.1) (:span 177 279)))\n (:identifiers (:sid . :s259.2) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002348@unknown@formal@none@1@S@We demonstrated that the Mycobacterium tuberculosis cell wall component lipoarabinomannan (LAM) is a very potent inducer of IL-1 beta gene expression in human monocytes and investigated the mechanism of this effect.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "lipoarabinomannan") (:form . "lipoarabinomannan")\n  (:end . 89) (:start . 72) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 185)\n  (:start . 173) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 199)\n  (:start . 190) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 207) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 214)\n  (:start . 208) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s259.3) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002350@unknown@formal@none@1@S@Within this DNA fragment, there were two novel 9-bp motifs (-90/-82 and -40/-32) with high homology to the nuclear factor-IL6 (NF-IL6) binding site.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "9-bp") (:form . "9-bp") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "CD") (:stem . "-90/-82") (:form . "-90/-82") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-40/-32") (:form . "-40/-32") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "NN") (:stem . "factor-il6") (:form . "factor-IL6") (:end . 125)\n  (:start . 115) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s259.5) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002351@unknown@formal@none@1@S@Site-directed mutagenesis demonstrated that the two NF-IL-6 motifs could be independently activated by LAM, LPS, or TNF-alpha and that they acted in an orientation-independent manner.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nf-il-6") (:form . "NF-IL-6") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 89) (:start . 76) (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 99)\n  (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "act") (:form . "acted") (:end . 145) (:start . 140)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "orientation-independent")\n  (:form . "orientation-independent") (:end . 175) (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 182)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s259.6) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002352@unknown@formal@none@1@S@DNA mobility shift assay revealed specific binding of nuclear protein ( s ) from LAM-, LPS-, or TNF-alpha- stimulated THP-1 cells to the NF-IL6 motifs.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lam-") (:form . "LAM-") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lps-") (:form . "LPS-") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tnf-alpha-") (:form . "TNF-alpha-") (:end . 106)\n  (:start . 96) (:id . 61))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nf-il6") (:form . "NF-IL6") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s259.7) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002353@unknown@formal@none@1@S@We conclude that the two NF-IL6 sites mediate induction of IL-1 beta in response to the stimuli LAM, LPS, and TNF-alpha.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nf-il6") (:form . "NF-IL6") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 119)\n  (:start . 110) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s259.8) (:did . :|93268332|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002354@unknown@formal@none@1@S@Synergism between the CD3 antigen- and CD2 antigen-derived signals.@(((:tag . "NNP") (:stem . "Synergism") (:form . "Synergism") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antigen-") (:form . "antigen-") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "antigen-derived") (:form . "antigen-derived")\n  (:end . 58) (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s260.1) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002355@unknown@formal@none@1@S@Exploration at the level of induction of DNA-binding proteins and characterization of the inhibitory activity of cyclosporine.@(((:tag . "NNP") (:stem . "Exploration") (:form . "Exploration") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 82) (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 125)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s260.2) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002356@unknown@formal@none@1@S@We have demonstrated earlier that the crosslinkage of the CD3/TCR complex with the CD2 antigen results in the proliferation of normal human T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "crosslinkage") (:form . "crosslinkage") (:end . 50)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD3/TCR") (:form . "CD3/TCR") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 123) (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s260.3) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002357@unknown@formal@none@1@S@The effect of this synergism was perceptible at the level of induction of the IL-2 gene, a process critical for T cell growth.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "perceptible") (:form . "perceptible") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 125)\n  (:start . 119) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s260.4) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002358@unknown@formal@none@1@S@To further understand the molecular and nuclear basis for this synergism, we have explored the induction of DNA-binding proteins in highly purified normal human T cells signaled via the CD3 and/or CD2 proteins.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 119)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 154)\n  (:start . 148) (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . "VBN") (:stem . "signal") (:form . "signaled") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 196)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s260.5) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002360@unknown@formal@none@1@S@The emergence of nuclear binding proteins was investigated using interleukin-2 sequence specific oligonucleotide probes in the electrophoretic mobility shift assay.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 112) (:start . 97) (:id . 54))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 119)\n  (:start . 113) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 142) (:start . 127) (:id . 58))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 151)\n  (:start . 143) (:id . 59))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 157)\n  (:start . 152) (:id . 60))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 163)\n  (:start . 158) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s260.7) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002361@unknown@formal@none@1@S@Our studies demonstrate for the first time that CD3 antigen-derived signals and CD2 antigen-derived signals are synergistic in inducing the emergence of transcription factors that bind to the NF-AT1, AP-1, and NF-kB sites located in the promoter/enhancer region of the IL-2 gene.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "antigen-derived") (:form . "antigen-derived")\n  (:end . 67) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "antigen-derived") (:form . "antigen-derived")\n  (:end . 99) (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 123)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 166) (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 174)\n  (:start . 167) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "nf-at1") (:form . "NF-AT1") (:end . 198)\n  (:start . 192) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 204) (:start . 200)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 215)\n  (:start . 210) (:id . 75))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 221)\n  (:start . 216) (:id . 76))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 229)\n  (:start . 222) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 236) (:start . 233)\n  (:id . 79))\n ((:tag . "NN") (:stem . "promoter/enhancer") (:form . "promoter/enhancer")\n  (:end . 254) (:start . 237) (:id . 80))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 261)\n  (:start . 255) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 264) (:start . 262)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 268) (:start . 265)\n  (:id . 83))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 273) (:start . 269)\n  (:id . 84))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 278) (:start . 274)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s260.8) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002362@unknown@formal@none@1@S@Moreover, cyclosporine, at concentrations readily accomplished in clinical practice, was found to inhibit the emergence of these DNA-binding proteins in normal human T cells signaled via cell surface proteins implicated in antigen-dependent T cell activation and in T cells stimulated by mobilization of cellular calcium and activation of protein kinase C.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 41) (:start . 27) (:id . 47))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "VBN") (:stem . "accomplish") (:form . "accomplished") (:end . 62)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "practice") (:form . "practice") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . 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"cell") (:end . 247) (:start . 243)\n  (:id . 78))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 258)\n  (:start . 248) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 265) (:start . 263)\n  (:id . 81))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 267) (:start . 266)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 273)\n  (:start . 268) (:id . 83))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 284)\n  (:start . 274) (:id . 84))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 287) (:start . 285)\n  (:id . 85))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 300)\n  (:start . 288) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 303) (:start . 301)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 312)\n  (:start . 304) (:id . 88))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 320)\n  (:start . 313) (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 324) (:start . 321)\n  (:id . 90))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 335)\n  (:start . 325) (:id . 91))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 338) (:start . 336)\n  (:id . 92))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 346)\n  (:start . 339) (:id . 93))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 353)\n  (:start . 347) (:id . 94))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 355) (:start . 354)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 356) (:start . 355)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s260.9) (:did . :|93269273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002363@unknown@formal@none@1@S@Calcium dependent activation of the NF-AT transcription factor by p59fyn.@(((:tag . "NN") (:stem . "calcium") (:form . "Calcium") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s261.1) (:did . :|93272960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002364@unknown@formal@none@1@S@A reporter gene under the control of a T-cell antigen receptor element was activated in Jurkat cells by antigen receptor triggering or by a combination of phorbol myristate acetate, which activates protein kinase C, and a calcium ionophore.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 151)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 180)\n  (:start . 173) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 205)\n  (:start . 198) (:id . 74))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 212)\n  (:start . 206) (:id . 75))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 214) (:start . 213)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 221) (:start . 220)\n  (:id . 79))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 229)\n  (:start . 222) (:id . 80))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 239)\n  (:start . 230) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s261.2) (:did . :|93272960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002365@unknown@formal@none@1@S@Both these signals were necessary for expression of the reporter gene.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s261.3) (:did . :|93272960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002366@unknown@formal@none@1@S@When co-transfected with a construct capable of overexpressing the tyrosine kinase p59fyn, the reporter gene was activated by PMA alone.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "co-transfecte") (:form . "co-transfected")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 62) (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s261.4) (:did . :|93272960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002367@unknown@formal@none@1@S@Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "replace") (:form . "replace") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x261.5.2) (:span 12 17)))\n (:ncues ((:id . :x261.5.1) (:span 52 55)))\n (:hscopes ((:id . :x261.5.2) (:span 12 86)))\n (:nscopes ((:id . :x261.5.1) (:span 52 86)))\n (:identifiers (:sid . :s261.5) (:did . :|93272960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002368@unknown@formal@none@1@S@The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EGTA") (:form . "EGTA") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 82) (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s261.6) (:did . :|93272960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002370@unknown@formal@none@1@S@Interaction between protein kinase C ( PKC ) - and glucocorticoid receptor ( GR ) -mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKC") (:form . 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"repeat") (:end . 307)\n  (:start . 301) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 309) (:start . 308)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 312) (:start . 309)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 313) (:start . 312)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 314) (:start . 313)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x262.2.1) (:span 105 114)))\n (:hscopes ((:id . :x262.2.1) (:span 0 313)))\n (:identifiers (:sid . :s262.2) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002371@unknown@formal@none@1@S@Here we report that this interference is cell specific, as TPA augmented dexamethasone-induced transcriptional activation of the MMTV LTR in several T cell lines but was inhibitory in NIH-3T3 fibroblasts.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "JJ") (:stem . "dexamethasone-induced")\n  (:form . "dexamethasone-induced") (:end . 94) (:start . 73) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 110) (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MMTV") (:form . "MMTV") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 180)\n  (:start . 170) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nih-3t3") (:form . "NIH-3T3") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 203)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s262.3) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002372@unknown@formal@none@1@S@TPA-GR synergism was determined to have occurred at the GR-responsive element (GRE) level by functional analysis of deletion mutants or synthetic GRE oligonucleotides driving chloramphenicol acetyl-transferase expression.@(((:tag . "NNP") (:stem . "TPA-GR") (:form . "TPA-GR") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "occur") (:form . "occurred") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gr-responsive") (:form . "GR-responsive")\n  (:end . 69) (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 166) (:start . 150) (:id . 66))\n ((:tag . "VBG") (:stem . "drive") (:form . "driving") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 190) (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "acetyl-transferase") (:form . "acetyl-transferase")\n  (:end . 209) (:start . 191) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 220)\n  (:start . 210) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s262.4) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002373@unknown@formal@none@1@S@Synergism required an intact GR DNA-binding domain, whereas amino- or carboxyl-terminal domains were dispensable.@(((:tag . "NNP") (:stem . "Synergism") (:form . "Synergism") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "amino-") (:form . "amino-") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 87) (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dispensable") (:form . "dispensable") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s262.5) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002374@unknown@formal@none@1@S@The effect was abrogated by the PKC inhibitor staurosporine, suggesting a role for PKC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "staurosporine") (:form . "staurosporine")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x262.6.1) (:span 61 71)))\n (:hscopes ((:id . :x262.6.1) (:span 61 86)))\n (:identifiers (:sid . :s262.6) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002375@unknown@formal@none@1@S@Increased c-jun, jun-B, and jun-D expression above basal levels and increased transcriptional activity of AP-1/TPA responsive elements fused to chloramphenicol acetyl-transferase vectors were observed in T cells treated with TPA alone or in combination with dexamethasone.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "jun-d") (:form . "jun-D") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "AP-1/TPA") (:form . "AP-1/TPA") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 159) (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "acetyl-transferase") (:form . "acetyl-transferase")\n  (:end . 178) (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 186)\n  (:start . 179) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 191) (:start . 187)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 200)\n  (:start . 192) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 205) (:start . 204)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 211)\n  (:start . 206) (:id . 70))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 219)\n  (:start . 212) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 224) (:start . 220)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 228) (:start . 225)\n  (:id . 73))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 234)\n  (:start . 229) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 237) (:start . 235)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 76))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 252)\n  (:start . 241) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 257) (:start . 253)\n  (:id . 78))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 271) (:start . 258) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s262.7) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002376@unknown@formal@none@1@S@The ability of Jun proteins to cooperate with GR in T cells has been investigated after transfection of c-jun, jun-B, or jun-D expression vectors, which augmented GR-dependent transcription from either MMTV LTR or GRE.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "cooperate") (:form . "cooperate") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 81)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 100)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "jun-d") (:form . "jun-D") (:end . 126)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 66))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 162)\n  (:start . 153) (:id . 70))\n ((:tag . "JJ") (:stem . "gr-dependent") (:form . "GR-dependent") (:end . 175)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 189) (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 201)\n  (:start . 195) (:id . 74))\n ((:tag . "NNP") (:stem . "MMTV") (:form . "MMTV") (:end . 206) (:start . 202)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 210) (:start . 207)\n  (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 213) (:start . 211)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 217) (:start . 214)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s262.8) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002377@unknown@formal@none@1@S@Conversely, c-jun and jun-B transfection blunted GR-dependent transcription in HeLa cells.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "blunt") (:form . "blunted") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "gr-dependent") (:form . "GR-dependent") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s262.9) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002378@unknown@formal@none@1@S@The presence of c-fos had a negative influence on GR function and correlated with the cell-specific synergistic or antagonistic activity of Jun with respect to GR;@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 99) (:start . 86) (:id . 57))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "antagonistic") (:form . "antagonistic") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 163) (:start . 162)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s262.10) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002380@unknown@formal@none@1@S@Furthermore overexpression of exogenous c-fos has an inhibitory effect on GR-dependent transcription from GRE in T cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 26) (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "gr-dependent") (:form . "GR-dependent") (:end . 86)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s262.12) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002381@unknown@formal@none@1@S@We propose that Jun plays a bifunctional role on GR-dependent transcriptional activation of GRE, selecting either synergistic or antagonistic activity depending on the cell-specific microenvironment.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "bifunctional") (:form . "bifunctional") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gr-dependent") (:form . "GR-dependent") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 77) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GRE") (:form . "GRE") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "select") (:form . "selecting") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "antagonistic") (:form . "antagonistic") (:end . 141)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 150)\n  (:start . 142) (:id . 62))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 160)\n  (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 181) (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "microenvironment") (:form . "microenvironment")\n  (:end . 198) (:start . 182) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x262.13.1) (:span 3 10)))\n (:hscopes ((:id . :x262.13.1) (:span 3 198)))\n (:identifiers (:sid . :s262.13) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002382@unknown@formal@none@1@S@In this regard, intracellular levels of c-fos appear to be influential.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 29) (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "influential") (:form . "influential") (:end . 70)\n  (:start . 59) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x262.14.1) (:span 46 52)))\n (:hscopes ((:id . :x262.14.1) (:span 16 70)))\n (:identifiers (:sid . :s262.14) (:did . :|93275333|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002383@unknown@formal@none@1@S@A concatenated form of Epstein-Barr viral DNA in lymphoblastoid cell lines induced by transfection with BZLF1.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "concatenate") (:form . "concatenated") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 63) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 98)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s263.1) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002384@unknown@formal@none@1@S@The replicative form of Epstein-Barr virus (EBV) DNA was studied using two lymphoblastoid cell lines, X50-7 and 6F11, which are latently infected by Epstein-Barr virus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 89) (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "X50-7") (:form . "X50-7") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "6f11") (:form . "6F11") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 145)\n  (:start . 137) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 161)\n  (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 167)\n  (:start . 162) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s263.2) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002385@unknown@formal@none@1@S@The lytic cycle of EBV infection was induced by transfection of the cells with the BRLF1/BZLF1 coding region of the P3HR-1 defective genome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 60)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "brlf1/bzlf1") (:form . "BRLF1/BZLF1") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p3hr-1") (:form . "P3HR-1") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s263.3) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002386@unknown@formal@none@1@S@We combined two techniques to identify the productive replicative form of Epstein-Barr viral DNA in the lytic cycle-induced cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "combine") (:form . "combined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "technique") (:form . "techniques") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 86)\n  (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "cycle-induced") (:form . "cycle-induced")\n  (:end . 123) (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s263.4) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002387@unknown@formal@none@1@S@Restriction enzyme analysis followed by Southern blot hybridization identified a significant increase in the fused fragment encompassing both ends of EBV DNA.@(((:tag . "NN") (:stem . "restriction") (:form . "Restriction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "southern") (:form . "Southern") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 67) (:start . 54) (:id . 49))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 92)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 101)\n  (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 136)\n  (:start . 124) (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "end") (:form . "ends") (:end . 146) (:start . 142)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s263.5) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002388@unknown@formal@none@1@S@This indicates an increase in either episomal DNA or concatameric linear DNA.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "episomal") (:form . "episomal") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "concatameric") (:form . "concatameric") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x263.6.1) (:span 30 36 50 52))\n  ((:id . :x263.6.3) (:span 5 14)))\n (:hscopes ((:id . :x263.6.1) (:span 30 76)) ((:id . :x263.6.3) (:span 5 76)))\n (:identifiers (:sid . :s263.6) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002390@unknown@formal@none@1@S@We propose from these results that the source of the fused fragment encompassing both ends of EBV DNA is a concatenated linear EBV DNA molecule, and that such a concatenated molecule most likely represents a replicative form of EBV DNA in productively infected cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "end") (:form . "ends") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "concatenate") (:form . "concatenated") (:end . 119)\n  (:start . 107) (:id . 62))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 143)\n  (:start . 135) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 158) (:start . 154)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "concatenate") (:form . "concatenated") (:end . 173)\n  (:start . 161) (:id . 72))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 182)\n  (:start . 174) (:id . 73))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 194)\n  (:start . 188) (:id . 75))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 205)\n  (:start . 195) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 207) (:start . 206)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 219)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 224) (:start . 220)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 231) (:start . 228)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 235) (:start . 232)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 238) (:start . 236)\n  (:id . 83))\n ((:tag . "RB") (:stem . "productively") (:form . "productively") (:end . 251)\n  (:start . 239) (:id . 84))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 260)\n  (:start . 252) (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 266)\n  (:start . 261) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x263.8.1) (:span 188 194)) ((:id . :x263.8.2) (:span 3 10)))\n (:hscopes ((:id . :x263.8.1) (:span 188 266))\n  ((:id . :x263.8.2) (:span 3 266)))\n (:identifiers (:sid . :s263.8) (:did . :|93276575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002391@unknown@formal@none@1@S@Regulation of the beta-globin locus.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 36) (:start . 35)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s264.1) (:did . :|93278095|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002392@unknown@formal@none@1@S@Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "RB") (:stem . "collectively") (:form . "collectively") (:end . 118)\n  (:start . 106) (:id . 57))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 125)\n  (:start . 119) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 143)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 150)\n  (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s264.2) (:did . :|93278095|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002393@unknown@formal@none@1@S@Recent studies have provided new insights into how the individual genes of the cluster are regulated through development.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s264.3) (:did . :|93278095|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002394@unknown@formal@none@1@S@The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "crux") (:form . "crux") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "VBZ") (:stem . "communicate") (:form . "communicates") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "gene-proximal") (:form . "gene-proximal")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s264.4) (:did . :|93278095|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002395@unknown@formal@none@1@S@Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "conditional") (:form . "conditional") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "GATA-2/estrogen") (:form . "GATA-2/estrogen")\n  (:end . 51) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "chimera") (:form . "chimera") (:end . 68)\n  (:start . 61) (:id . 49))\n ((:tag . "VBZ") (:stem . "arrest") (:form . "arrests") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 86)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 102) (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hormone-dependent") (:form . "hormone-dependent")\n  (:end . 125) (:start . 108) (:id . 55))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 132)\n  (:start . 126) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s265.1) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002396@unknown@formal@none@1@S@The GATA factors are a family of transcriptional regulatory proteins in eukaryotes that share extensive homology in their DNA-binding domains.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 48) (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 133)\n  (:start . 122) (:id . 60))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s265.2) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002397@unknown@formal@none@1@S@One enigmatic aspect of GATA factor expression is that several GATA proteins, which ostensibly share the same DNA-binding site specificity, are coexpressed in erythroid cells.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "enigmatic") (:form . "enigmatic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "aspect") (:form . "aspect") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "RB") (:stem . "ostensibly") (:form . "ostensibly") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 100)\n  (:start . 95) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 138)\n  (:start . 127) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 155)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s265.3) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002398@unknown@formal@none@1@S@To elucidate the roles of individual GATA factors in erythropoiesis, conditional alleles of GATA-1, GATA-2, and GATA-3 were prepared by fusing each of the factors to the hormone-binding domain of the human estrogen receptor (ER).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 67) (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "conditional") (:form . "conditional") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "fuse") (:form . "fusing") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "hormone-binding") (:form . "hormone-binding")\n  (:end . 185) (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 192)\n  (:start . 186) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 205)\n  (:start . 200) (:id . 76))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 214)\n  (:start . 206) (:id . 77))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 223)\n  (:start . 215) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 225) (:start . 224)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 227) (:start . 225)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s265.4) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002400@unknown@formal@none@1@S@When stably introduced into primary erythroblasts or conditionally transformed erythroid progenitors cells, exogenous GATA-2/ER promoted proliferation and inhibited terminal differentiation in an estrogen-dependent manner.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "RB") (:stem . "conditionally") (:form . "conditionally")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 78)\n  (:start . 67) (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 88)\n  (:start . 79) (:id . 51))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 100)\n  (:start . 89) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 117)\n  (:start . 108) (:id . 55))\n ((:tag . "NN") (:stem . "gata-2/er") (:form . "GATA-2/ER") (:end . 127)\n  (:start . 118) (:id . 56))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 136)\n  (:start . 128) (:id . 57))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 150) (:start . 137) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 164)\n  (:start . 155) (:id . 60))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 173)\n  (:start . 165) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 189) (:start . 174) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 195) (:start . 193)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "estrogen-dependent") (:form . "estrogen-dependent")\n  (:end . 214) (:start . 196) (:id . 65))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 221)\n  (:start . 215) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s265.6) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002401@unknown@formal@none@1@S@These phenotypic effects are specifically attributable to the action of ectopically expressed GATA-2/ER because erythroblasts expressing exogenous GATA-2 are constitutively arrested in differentiation and because erythroid progenitors expressing either Gal/ER or GATA-3/ER do not display a hormone-responsive block in differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 54)\n  (:start . 42) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "RB") (:stem . "ectopically") (:form . "ectopically") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "gata-2/er") (:form . "GATA-2/ER") (:end . 103)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 111)\n  (:start . 104) (:id . 55))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 125) (:start . 112) (:id . 56))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 136)\n  (:start . 126) (:id . 57))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 146)\n  (:start . 137) (:id . 58))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 153)\n  (:start . 147) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 157) (:start . 154)\n  (:id . 60))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 172) (:start . 158) (:id . 61))\n ((:tag . "VBN") (:stem . "arrest") (:form . "arrested") (:end . 181)\n  (:start . 173) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 200) (:start . 185) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 65))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 212)\n  (:start . 205) (:id . 66))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 222)\n  (:start . 213) (:id . 67))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 234)\n  (:start . 223) (:id . 68))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 245)\n  (:start . 235) (:id . 69))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 252)\n  (:start . 246) (:id . 70))\n ((:tag . "NNP") (:stem . "Gal/ER") (:form . "Gal/ER") (:end . 259)\n  (:start . 253) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 262) (:start . 260)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GATA-3/ER") (:form . "GATA-3/ER") (:end . 272)\n  (:start . 263) (:id . 73))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 275) (:start . 273)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 279) (:start . 276)\n  (:id . 75))\n ((:tag . "VB") (:stem . "display") (:form . "display") (:end . 287)\n  (:start . 280) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 289) (:start . 288)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "hormone-responsive") (:form . "hormone-responsive")\n  (:end . 308) (:start . 290) (:id . 78))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 314)\n  (:start . 309) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 317) (:start . 315)\n  (:id . 80))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 333) (:start . 318) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 334) (:start . 333)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x265.7.1) (:span 276 279)))\n (:nscopes ((:id . :x265.7.1) (:span 276 333)))\n (:identifiers (:sid . :s265.7) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002402@unknown@formal@none@1@S@Thus, the GATA-2 transcription factor appears to play a role in regulating the self-renewal capacity of early erythroid progenitor cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "self-renewal") (:form . "self-renewal") (:end . 91)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x265.8.1) (:span 38 45)))\n (:hscopes ((:id . :x265.8.1) (:span 6 136)))\n (:identifiers (:sid . :s265.8) (:did . :|93279468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002403@unknown@formal@none@1@S@Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 26)\n  (:start . 19) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 42) (:start . 27) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mad3") (:form . "MAD3") (:end . 50) (:start . 46)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 131)\n  (:start . 126) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s266.1) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002404@unknown@formal@none@1@S@Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 34) (:start . 16) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 101) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 127)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 160)\n  (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 169)\n  (:start . 164) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 183)\n  (:start . 172) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 192)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s266.2) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002405@unknown@formal@none@1@S@However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "JJ") (:stem . "lps-generated") (:form . "LPS-generated")\n  (:end . 156) (:start . 143) (:id . 65))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 179)\n  (:start . 169) (:id . 68))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 186)\n  (:start . 180) (:id . 69))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 194)\n  (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s266.3) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002406@unknown@formal@none@1@S@Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-rel/p50") (:form . "c-Rel/p50") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 155)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s266.4) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002407@unknown@formal@none@1@S@Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 61) (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 92)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 129)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "JJ") (:stem . "ester-sensitive") (:form . "ester-sensitive")\n  (:end . 156) (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 171)\n  (:start . 165) (:id . 64))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 173) (:start . 172)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s266.5) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002408@unknown@formal@none@1@S@Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 120)\n  (:start . 113) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s266.6) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002410@unknown@formal@none@1@S@LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MAD3") (:form . "MAD3") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 111)\n  (:start . 103) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MAD3") (:form . "MAD3") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 68))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 141)\n  (:start . 133) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mad3") (:form . "MAD3") (:end . 149) (:start . 145)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 157)\n  (:start . 150) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 73))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 162) (:start . 161)\n  (:id . 74))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 164) (:start . 163)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s266.8) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002411@unknown@formal@none@1@S@Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-rel/p50") (:form . "c-Rel/p50") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 141) (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MAD3") (:form . "MAD3") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s266.9) (:did . :|93280143|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002412@unknown@formal@none@1@S@Induction of CD8 antigen and suppressor activity by glucocorticoids in a CEM human leukemic cell clone.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 67) (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s267.1) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002413@unknown@formal@none@1@S@The relationship between glucocorticoid effect and regulation of cell surface antigens was investigated in two models of leukemic cell lines, CEM C7 denoted (r+, ly+) and CEM C1 (r+, ly-).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 39) (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 46)\n  (:start . 40) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 103)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C7") (:form . "C7") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "denote") (:form . "denoted") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "r+") (:form . "r+") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "ly+") (:form . "ly+") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "C1") (:form . "C1") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "r+") (:form . "r+") (:end . 181) (:start . 179)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "ly-") (:form . "ly-") (:end . 186) (:start . 183)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s267.2) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002414@unknown@formal@none@1@S@The reactivity of murine monoclonal antibodies, anti-CD4-FITC, anti-CD8-FITC, anti-CD2-FITC and anti-calla-FITC, were analyzed using flow cytometry.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "anti-cd4-fitc") (:form . "anti-CD4-FITC")\n  (:end . 61) (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "anti-cd8-fitc") (:form . "anti-CD8-FITC")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "anti-cd2-fitc") (:form . "anti-CD2-FITC")\n  (:end . 91) (:start . 78) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "anti-calla-fitc") (:form . "anti-calla-FITC")\n  (:end . 111) (:start . 96) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 132) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 147)\n  (:start . 138) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s267.3) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002415@unknown@formal@none@1@S@The suppressor function was determined using [3H]thymidine incorporation into phytohemagglutinin-activated peripheral blood lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "3H]thymidine") (:form . "3H]thymidine") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "phytohemagglutinin-activated")\n  (:form . "phytohemagglutinin-activated") (:end . 106) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 117)\n  (:start . 107) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 123)\n  (:start . 118) (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 135)\n  (:start . 124) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s267.4) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002416@unknown@formal@none@1@S@Dexamethasone treatment of a human leukemic cell clone CEM C7 caused an increase in a subset of cells expressing the surface antigen CD8, which is present on suppressor and cytotoxic T-lymphocytes.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C7") (:form . "C7") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 168)\n  (:start . 158) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 196) (:start . 183) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s267.5) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002417@unknown@formal@none@1@S@By comparison, there was no modification of the expression of CD4 antigen, which is expressed at high levels in these cells.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 108)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x267.6.1) (:span 25 27)))\n (:nscopes ((:id . :x267.6.1) (:span 25 73)))\n (:identifiers (:sid . :s267.6) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002418@unknown@formal@none@1@S@After two days of treatment with 5 x 10(-8) M dexamethasone, CEM C7 cells showed a two-fold increase in suppressor activity compared to untreated cells.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10(-8)") (:form . "10(-8)") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 59) (:start . 46) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C7") (:form . "C7") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 80) (:start . 74)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "two-fold") (:form . "two-fold") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 114)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 145)\n  (:start . 136) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s267.7) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002420@unknown@formal@none@1@S@Furthermore, no modification of the suppressor function in CEM C1 cells by dexamethasone was observed.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "C1") (:form . "C1") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x267.9.1) (:span 13 15)))\n (:nscopes ((:id . :x267.9.1) (:span 13 101)))\n (:identifiers (:sid . :s267.9) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002421@unknown@formal@none@1@S@In the human leukemic cells studied here, the ability to induce CD8 antigen expression in a CD4+ cells correlates with the ability to induce cell lysis in a glucocorticoid receptor positive cell population.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 140)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 151)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 171) (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 180)\n  (:start . 172) (:id . 72))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 189)\n  (:start . 181) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 205)\n  (:start . 195) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s267.10) (:did . :|93280865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002422@unknown@formal@none@1@S@Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 102) (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s268.1) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002423@unknown@formal@none@1@S@We have previously reported that the T lymphocytes of a child with severe combined immunodeficiency are defective in the transcription of several lymphokine genes that include IL2, IL3, IL4, and IL5, which encode interleukins 2, 3, 4, and 5 (IL-2, -3, -4, and -5).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . 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"CD") (:stem . "2") (:form . "2") (:end . 227) (:start . 226)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 81))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 230) (:start . 229)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 231) (:start . 230)\n  (:id . 83))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 233) (:start . 232)\n  (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 234) (:start . 233)\n  (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 238) (:start . 235)\n  (:id . 86))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 240) (:start . 239)\n  (:id . 87))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 242) (:start . 241)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 246) (:start . 242)\n  (:id . 89))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 90))\n ((:tag . "CD") (:stem . "-3") (:form . "-3") (:end . 250) (:start . 248)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 251) (:start . 250)\n  (:id . 92))\n ((:tag . "CD") (:stem . "-4") (:form . "-4") (:end . 254) (:start . 252)\n  (:id . 93))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 255) (:start . 254)\n  (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 259) (:start . 256)\n  (:id . 95))\n ((:tag . "CD") (:stem . "-5") (:form . "-5") (:end . 262) (:start . 260)\n  (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 263) (:start . 262)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 98)))@@@1@57@((:identifiers (:sid . :s268.2) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002424@unknown@formal@none@1@S@To determine whether the defect in the patient 's T lymphocytes involved a trans-acting factor common to the affected lymphokine genes, we examined the ability of nuclear factors from the patient 's T lymphocytes to bind response elements present in the regulatory region of IL2.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . 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"response") (:end . 229)\n  (:start . 221) (:id . 79))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 238)\n  (:start . 230) (:id . 80))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 246)\n  (:start . 239) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 249) (:start . 247)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 253) (:start . 250)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 264)\n  (:start . 254) (:id . 84))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 271)\n  (:start . 265) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 274) (:start . 272)\n  (:id . 86))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 278) (:start . 275)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x268.3.1) (:span 13 20)))\n (:hscopes ((:id . :x268.3.1) (:span 13 134)))\n (:identifiers (:sid . :s268.3) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002425@unknown@formal@none@1@S@Nuclear factor NF-kB, activation protein 1 (AP-1), OCT-1, and NF-IL-2B binding activity were normal.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "OCT-1") (:form . "OCT-1") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-IL-2B") (:form . "NF-IL-2B") (:end . 70)\n  (:start . 62) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s268.4) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002426@unknown@formal@none@1@S@In contrast, the binding of the nuclear factor of activated T cells (NF-AT) to its response element in the IL2 enhancer and to an NF-AT-like response element present in the IL4 enhancer was abnormal.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 91)\n  (:start . 83) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 99)\n  (:start . 92) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 119)\n  (:start . 111) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 129) (:start . 127)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nf-at-like") (:form . "NF-AT-like") (:end . 140)\n  (:start . 130) (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 149)\n  (:start . 141) (:id . 70))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 157)\n  (:start . 150) (:id . 71))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 165)\n  (:start . 158) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 74))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 176) (:start . 173)\n  (:id . 75))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 185)\n  (:start . 177) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 189) (:start . 186)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 198)\n  (:start . 190) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s268.5) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002427@unknown@formal@none@1@S@To ascertain whether the abnormal NF-AT binding activity was related to an impaired function, we transfected patient and control T lymphocytes with constructs containing the reporter gene encoding chloramphenicol acetyl transferase (CAT) under the control of the entire IL2 regulatory region or of multimers of individual enhancer sequences.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "ascertain") (:form . "ascertain") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "transfecte") (:form . "transfected") (:end . 108)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 169)\n  (:start . 159) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 187) (:start . 183)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 212) (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 219)\n  (:start . 213) (:id . 72))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 231)\n  (:start . 220) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 236) (:start . 233)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 237) (:start . 236)\n  (:id . 76))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 243)\n  (:start . 238) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 78))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 255)\n  (:start . 248) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 258) (:start . 256)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 262) (:start . 259)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 269)\n  (:start . 263) (:id . 82))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 273) (:start . 270)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 284)\n  (:start . 274) (:id . 84))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 291)\n  (:start . 285) (:id . 85))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 294) (:start . 292)\n  (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 297) (:start . 295)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "multimer") (:form . "multimers") (:end . 307)\n  (:start . 298) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 310) (:start . 308)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 321)\n  (:start . 311) (:id . 90))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 330)\n  (:start . 322) (:id . 91))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 340)\n  (:start . 331) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 341) (:start . 340)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x268.6.1) (:span 13 20)))\n (:hscopes ((:id . :x268.6.1) (:span 13 92)))\n (:identifiers (:sid . :s268.6) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002428@unknown@formal@none@1@S@CAT expression directed by the IL2 regulatory region or by a multimer of the NF-AT-binding site was markedly lower in the patient relative to controls.@(((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "multimer") (:form . "multimer") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 114) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 150)\n  (:start . 142) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s268.7) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002430@unknown@formal@none@1@S@These results indicate that an abnormality of/or influencing NF-AT may underlie the multiple lymphokine deficiency in this patient.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of/or") (:form . "of/or") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "influence") (:form . "influencing") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x268.9.1) (:span 67 70)) ((:id . :x268.9.2) (:span 14 27)))\n (:hscopes ((:id . :x268.9.1) (:span 67 130))\n  ((:id . :x268.9.2) (:span 14 130)))\n (:identifiers (:sid . :s268.9) (:did . :|93281652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002431@unknown@formal@none@1@S@Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s269.1) (:did . :|93283670|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002432@unknown@formal@none@1@S@The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was studied in eosinophils and basophils.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s269.2) (:did . :|93283670|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002433@unknown@formal@none@1@S@Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3.@(((:tag . "NNS") (:stem . "eosinophil") (:form . "Eosinophils") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s269.3) (:did . :|93283670|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002434@unknown@formal@none@1@S@Basophils express GATA-2 and GATA-3.@(((:tag . "NNS") (:stem . "basophil") (:form . "Basophils") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 36) (:start . 35)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s269.4) (:did . :|93283670|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002435@unknown@formal@none@1@S@Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "subline") (:form . "sublines") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-5") (:form . "interleukin-5")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "butyric") (:form . "butyric") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 134)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 154)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "eosinophil-specific")\n  (:form . "eosinophil-specific") (:end . 177) (:start . 158) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 183)\n  (:start . 178) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 66))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 192)\n  (:start . 185) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 199)\n  (:start . 193) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GATA-2") (:form . "GATA-2") (:end . 209)\n  (:start . 203) (:id . 70))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 214) (:start . 210)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 223)\n  (:start . 215) (:id . 72))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 234)\n  (:start . 224) (:id . 73))\n ((:tag . "JJ") (:stem . "constant") (:form . "constant") (:end . 243)\n  (:start . 235) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s269.5) (:did . :|93283670|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002436@unknown@formal@none@1@S@The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 152)\n  (:start . 140) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 161)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x269.6.1) (:span 120 123))\n  ((:id . :x269.6.2) (:span 69 77)))\n (:hscopes ((:id . :x269.6.1) (:span 120 161))\n  ((:id . :x269.6.2) (:span 69 161)))\n (:identifiers (:sid . :s269.6) (:did . :|93283670|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002437@unknown@formal@none@1@S@Proliferation index as a prognostic marker in breast cancer.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "index") (:form . "index") (:end . 19) (:start . 14)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "prognostic") (:form . "prognostic") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s270.1) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002438@unknown@formal@none@1@S@BACKGROUND .@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 12) (:start . 11)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s270.2) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002440@unknown@formal@none@1@S@In this study, the proliferative activity of 129 primary breast cancers was investigated, and the results were related to prognosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 32) (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "129") (:form . "129") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "cancer") (:form . "cancers") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 88)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "prognosis") (:form . "prognosis") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s270.4) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002441@unknown@formal@none@1@S@METHODS .@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 9) (:start . 8) (:id . 43)))@@@1@2@((:identifiers (:sid . :s270.5) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002442@unknown@formal@none@1@S@Tumor samples, obtained from 129 patients who underwent surgery between January 1987 and December 1988, were processed for staining by an immunohistochemical procedure (avidin-biotin complex).@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "129") (:form . "129") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "undergo") (:form . "underwent") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "surgery") (:form . "surgery") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "January") (:form . "January") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "CD") (:stem . "1987") (:form . "1987") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "December") (:form . "December") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "CD") (:stem . "1988") (:form . "1988") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "process") (:form . "processed") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immunohistochemical")\n  (:form . "immunohistochemical") (:end . 157) (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "NN") (:stem . "avidin-biotin") (:form . "avidin-biotin")\n  (:end . 182) (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 190)\n  (:start . 183) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s270.6) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002443@unknown@formal@none@1@S@The median time of observation was 42 months (range, 31-55 months).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "median") (:form . "median") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "31-55") (:form . "31-55") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s270.7) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002444@unknown@formal@none@1@S@Life-table analysis (Mantel-Cox) was used to assess the probability of disease-free survival (DFS) and overall survival (OS).@(((:tag . "JJ") (:stem . "life-table") (:form . "Life-table") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Mantel-Cox") (:form . "Mantel-Cox") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "disease-free") (:form . "disease-free") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DFS") (:form . "DFS") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "OS") (:form . "OS") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s270.8) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002445@unknown@formal@none@1@S@RESULTS .@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 9) (:start . 8) (:id . 43)))@@@1@2@((:identifiers (:sid . :s270.9) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002446@unknown@formal@none@1@S@Tumors with high Ki-67 proliferation indices (> 20%) were associated with a higher 4-year probability of relapse of disease (55.3 % versus 79.1 %; P = 0.003) and death (71 % versus 95.6 %; P = 0.00005) when compared with tumors with low Ki-67 values.@(((:tag . "NNS") (:stem . "tumor") (:form . "Tumors") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "index") (:form . "indices") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "SYM") (:stem . ">") (:form . 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";") (:end . 146) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 148) (:start . 147)\n  (:id . 71))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 150) (:start . 149)\n  (:id . 72))\n ((:tag . "CD") (:stem . "0.003") (:form . "0.003") (:end . 156)\n  (:start . 151) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 75))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 167)\n  (:start . 162) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 77))\n ((:tag . "CD") (:stem . "71") (:form . "71") (:end . 171) (:start . 169)\n  (:id . 78))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 173) (:start . 172)\n  (:id . 79))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 180)\n  (:start . 174) (:id . 80))\n ((:tag . "CD") (:stem . 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"tumors") (:end . 227)\n  (:start . 221) (:id . 91))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 232) (:start . 228)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 236) (:start . 233)\n  (:id . 93))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 242)\n  (:start . 237) (:id . 94))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 249)\n  (:start . 243) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s270.10) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002447@unknown@formal@none@1@S@In addition, this proliferative parameter maintained its prognostic significance when the patients were stratified according to lymph node involvement, menopausal status, and nuclear estrogen receptor content.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "maintain") (:form . "maintained") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "prognostic") (:form . "prognostic") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 80)\n  (:start . 68) (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "stratify") (:form . "stratified") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 150)\n  (:start . 139) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "menopausal") (:form . "menopausal") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 169)\n  (:start . 163) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 182)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 191)\n  (:start . 183) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 200)\n  (:start . 192) (:id . 69))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 208)\n  (:start . 201) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s270.11) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002448@unknown@formal@none@1@S@CONCLUSIONS .@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 13) (:start . 12)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s270.12) (:did . :|93284506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002450@unknown@formal@none@1@S@Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.@(((:tag . "JJ") (:stem . "defective") (:form . "Defective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multidrug-resistant")\n  (:form . "multidrug-resistant") (:end . 66) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "ester-induced") (:form . "ester-induced")\n  (:end . 129) (:start . 116) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 139)\n  (:start . 130) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 155) (:start . 140) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s271.1) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002451@unknown@formal@none@1@S@Previous studies have demonstrated that human HL-60 myeloid leukemia cells differentiate in response to phorbol esters.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 88) (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 118)\n  (:start . 112) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s271.2) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002452@unknown@formal@none@1@S@This event is associated with induction of the c-jun early response gene and appearance of a monocytic phenotype.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s271.3) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002453@unknown@formal@none@1@S@The present studies have examined the effects of vincristine-selected, multidrug resistance on 12-O-tetradecanoylphorbol-13-acetate ( TPA ) -induced HL-60 cell differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "vincristine-selected")\n  (:form . "vincristine-selected") (:end . 69) (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "multidrug") (:form . "multidrug") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 131) (:start . 95)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 137) (:start . 134)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "-induced") (:form . "-induced") (:end . 148)\n  (:start . 140) (:id . 59))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 154)\n  (:start . 149) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 159) (:start . 155)\n  (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 175) (:start . 160) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s271.4) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002454@unknown@formal@none@1@S@The results demonstrate that multidrug-resistant HL-60 cells, designated HL-60/vinc, fail to respond to TPA with an increase in c-jun transcripts or other phenotypic characteristics of monocytic differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multidrug-resistant")\n  (:form . "multidrug-resistant") (:end . 48) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "NNP") (:stem . "HL-60/vinc") (:form . "HL-60/vinc") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 181) (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 194)\n  (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 210) (:start . 195) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s271.5) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002455@unknown@formal@none@1@S@By contrast, treatment of HL-60/vinc cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases, induces c-jun transcription, growth arrest, and expression of the c-fms gene.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hl-60/vinc") (:form . "HL-60/vinc") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 94) (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 115)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 152)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-fms") (:form . "c-fms") (:end . 188)\n  (:start . 183) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 193) (:start . 189)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s271.6) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002456@unknown@formal@none@1@S@Studies were also performed with an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HL-60/vinc") (:form . "HL-60/vinc") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "revertant") (:form . "revertant") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HL-60/vinc/R") (:form . "HL-60/vinc/R") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "regain") (:form . "regained") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "vincristine") (:form . "vincristine") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s271.7) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002457@unknown@formal@none@1@S@The finding that HL-60/vinc/R cells respond to TPA with induction of a monocytic phenotype, but not c-jun expression, suggests that c-jun induction is not obligatory for monocytic differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HL-60/vinc/R") (:form . "HL-60/vinc/R") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 165)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 195) (:start . 180) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x271.8.2) (:span 118 126)))\n (:ncues ((:id . :x271.8.1) (:span 151 154))\n  ((:id . :x271.8.3) (:span 96 99)))\n (:hscopes ((:id . :x271.8.2) (:span 118 195)))\n (:nscopes ((:id . :x271.8.1) (:span 151 195))\n  ((:id . :x271.8.3) (:span 96 116)))\n (:identifiers (:sid . :s271.8) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002458@unknown@formal@none@1@S@Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "jun-b") (:form . "jun-B") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HL-60/vinc") (:form . "HL-60/vinc") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HL-60/vinc/R") (:form . "HL-60/vinc/R")\n  (:end . 119) (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 151)\n  (:start . 141) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 165)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HL-60/vinc") (:form . "HL-60/vinc") (:end . 183)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s271.9) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002460@unknown@formal@none@1@S@Although HL-60 and HL-60/vinc/R cells demonstrated translocation of PKC activity, this subcellular redistribution was undetectable in HL-60/vinc cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HL-60/vinc/R") (:form . "HL-60/vinc/R") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 64) (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "redistribution") (:form . "redistribution")\n  (:end . 113) (:start . 99) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 130)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hl-60/vinc") (:form . "HL-60/vinc") (:end . 144)\n  (:start . 134) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s271.11) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002461@unknown@formal@none@1@S@Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.@(((:tag . "NN") (:stem . "activity") (:form . "Activity") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 87) (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Y-peptide") (:form . "Y-peptide") (:end . 106)\n  (:start . 97) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 130)\n  (:start . 120) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "tpa-treated") (:form . "TPA-treated") (:end . 145)\n  (:start . 134) (:id . 59))\n ((:tag . "NNP") (:stem . "HL-60/vinc") (:form . "HL-60/vinc") (:end . 156)\n  (:start . 146) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 162)\n  (:start . 157) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 167) (:start . 164)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 171) (:start . 168)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 183)\n  (:start . 175) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 194)\n  (:start . 187) (:id . 68))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 199) (:start . 195)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x271.12.1) (:span 168 171)))\n (:nscopes ((:id . :x271.12.1) (:span 168 199)))\n (:identifiers (:sid . :s271.12) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002462@unknown@formal@none@1@S@Taken together, these findings suggest that vincristine resistance confers insensitivity to TPA-induced differentiation and can include defects in PKC-mediated signaling events and induction of jun/fos early response gene expression.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vincristine") (:form . "vincristine") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 88) (:start . 75) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tpa-induced") (:form . "TPA-induced") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 119) (:start . 104) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 127) (:start . 124)\n  (:id . 57))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 135)\n  (:start . 128) (:id . 58))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 143)\n  (:start . 136) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pkc-mediated") (:form . "PKC-mediated") (:end . 159)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 169)\n  (:start . 160) (:id . 62))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 176)\n  (:start . 170) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 190)\n  (:start . 181) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 66))\n ((:tag . "NN") (:stem . "jun/fos") (:form . "jun/fos") (:end . 201)\n  (:start . 194) (:id . 67))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 207)\n  (:start . 202) (:id . 68))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 216)\n  (:start . 208) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 221) (:start . 217)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 232)\n  (:start . 222) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x271.13.1) (:span 124 127))\n  ((:id . :x271.13.2) (:span 31 38)))\n (:hscopes ((:id . :x271.13.1) (:span 124 232))\n  ((:id . :x271.13.2) (:span 31 232)))\n (:identifiers (:sid . :s271.13) (:did . :|93286051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002463@unknown@formal@none@1@S@Differential contribution of herpes simplex virus type 1 gene products and cellular factors to the activation of human immunodeficiency virus type 1 provirus.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 25)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "NN") (:stem . "herpes") (:form . "herpes") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "simplex") (:form . "simplex") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 135) (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s272.1) (:did . :|93287269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002464@unknown@formal@none@1@S@We have previously reported that infection with herpes simplex virus type 1 (HSV-1) activates expression of the human immunodeficiency virus type 1 (HIV-1) provirus in T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "herpes") (:form . "herpes") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "simplex") (:form . "simplex") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hsv-1") (:form . "HSV-1") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 134) (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 164)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s272.2) (:did . :|93287269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002465@unknown@formal@none@1@S@Activation of the HIV-1 provirus correlated with the activation of binding of 55- and 85-kDa proteins to the kappa B enhancer and binding of the 50-kDa HLP-1 protein to the LBP-1 sequences of the HIV-1 long terminal repeat.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "CD") (:stem . "55-") (:form . "55-") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "85-kda") (:form . "85-kDa") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 151)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "hlp-1") (:form . "HLP-1") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 165)\n  (:start . 158) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "NN") (:stem . "lbp-1") (:form . "LBP-1") (:end . 178)\n  (:start . 173) (:id . 72))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 188)\n  (:start . 179) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 201)\n  (:start . 196) (:id . 76))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 206) (:start . 202)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 215)\n  (:start . 207) (:id . 78))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 222)\n  (:start . 216) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s272.3) (:did . :|93287269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002466@unknown@formal@none@1@S@Further examination of this system has shown that the inhibition of HSV-1 replication by the antiviral drug acyclovir does not inhibit HSV-1-mediated induction of HIV-1 provirus.@(((:tag . "JJR") (:stem . "far") (:form . "Further") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "examination") (:form . "examination") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hsv-1") (:form . "HSV-1") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "acyclovir") (:form . "acyclovir") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "JJ") (:stem . "hsv-1-mediated") (:form . "HSV-1-mediated")\n  (:end . 149) (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 177)\n  (:start . 169) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x272.4.1) (:span 123 126)))\n (:nscopes ((:id . :x272.4.1) (:span 123 177)))\n (:identifiers (:sid . :s272.4) (:did . :|93287269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002467@unknown@formal@none@1@S@Surprisingly, the NF-kappa B and HLP-1 binding activities were substantially inhibited in acyclovir-treated cells.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hlp-1") (:form . "HLP-1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "acyclovir-treated") (:form . "acyclovir-treated")\n  (:end . 107) (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s272.5) (:did . :|93287269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002468@unknown@formal@none@1@S@In the transient-transfection assay, ICP0, but not ICP4, activated the HIV-1 long terminal repeat promoter region and the effect of ICP0 was greatly enhanced in the presence of the NF-kappa B binding proteins, suggesting that induction of the HIV-1 provirus involves cooperation between the HSV-1-activated cellular factor, NF-kappa B, and the virus-encoded transactivator, ICP0.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ|NN") (:stem . "transient-transfection")\n  (:form . "transient-transfection") (:end . 29) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ICP0") (:form . "ICP0") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . 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5002470@unknown@formal@none@1@S@Glucocorticoid receptor (GR) hormone-binding activity was studied by a whole-cell method in mononuclear cells (MNC) from peripheral blood of 7 patients during the hemodynamic compensatory phase of sepsis.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hormone-binding") (:form . "hormone-binding")\n  (:end . 44) (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "whole-cell") (:form . "whole-cell") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "hemodynamic") (:form . "hemodynamic") (:end . 174)\n  (:start . 163) (:id . 69))\n ((:tag . "JJ") (:stem . "compensatory") (:form . "compensatory") (:end . 187)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 203)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s273.2) (:did . :|93289270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002471@unknown@formal@none@1@S@4 patients were receiving dopamine, which did not affect the GR count.@(((:tag . "CD") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "receive") (:form . "receiving") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "count") (:form . "count") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x273.3.1) (:span 46 49)))\n (:nscopes ((:id . :x273.3.1) (:span 46 69)))\n (:identifiers (:sid . :s273.3) (:did . :|93289270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002472@unknown@formal@none@1@S@The patients ' plasma cortisol concentrations were normal or slightly elevated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 45) (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s273.4) (:did . :|93289270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002473@unknown@formal@none@1@S@Despite a wide range, the mean GR count and affinity in MNC from septic patients did not differ from those in normal controls, suggesting that glucocorticoids could still be effective in the hemodynamic compensatory phase of sepsis.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "count") (:form . "count") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 52)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "septic") (:form . "septic") (:end . 71)\n  (:start . 65) (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 80)\n  (:start . 72) (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 95)\n  (:start . 89) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 106)\n  (:start . 101) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 116)\n  (:start . 110) (:id . 64))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 125)\n  (:start . 117) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 137)\n  (:start . 127) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 158) (:start . 143) (:id . 69))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 183)\n  (:start . 174) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "hemodynamic") (:form . "hemodynamic") (:end . 202)\n  (:start . 191) (:id . 76))\n ((:tag . "JJ") (:stem . "compensatory") (:form . "compensatory") (:end . 215)\n  (:start . 203) (:id . 77))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 221)\n  (:start . 216) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 79))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 231)\n  (:start . 225) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x273.5.1) (:span 159 164))\n  ((:id . :x273.5.2) (:span 127 137)))\n (:ncues ((:id . :x273.5.3) (:span 85 88)))\n (:hscopes ((:id . :x273.5.1) (:span 159 231))\n  ((:id . :x273.5.2) (:span 127 231)))\n (:nscopes ((:id . :x273.5.3) (:span 85 125)))\n (:identifiers (:sid . :s273.5) (:did . :|93289270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002474@unknown@formal@none@1@S@Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7.@(((:tag . "NN") (:stem . "dependence") (:form . "Dependence") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 59) (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "established") (:form . "established") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 103) (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 111)\n  (:start . 104) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 136) (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 146) (:start . 142)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s274.1) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002475@unknown@formal@none@1@S@Erythroid differentiation involves the activation of a number of erythroid-specific genes, most of which, including the globin genes and the erythropoietin receptor (Epo-R) gene, are , at least in part, regulated by the transcription factor GATA-1.@(((:tag . "JJ") (:stem . "erythroid") (:form . "Erythroid") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 25) (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 83) (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 89) (:start . 84)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 155) (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Epo-R") (:form . "Epo-R") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 193)\n  (:start . 188) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 212)\n  (:start . 203) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 215) (:start . 213)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 233) (:start . 220) (:id . 81))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 240)\n  (:start . 234) (:id . 82))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 247)\n  (:start . 241) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s274.2) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002476@unknown@formal@none@1@S@In order to understand the relationship, if any, between expression of GATA-1, response to Epo and erythroid differentiation, we analyzed the expression of GATA-1, Epo-R and globin genes in an Epo-dependent human cell line, UT-7 Epo.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 108)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 124) (:start . 109) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "epo-r") (:form . "Epo-R") (:end . 169)\n  (:start . 164) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 180)\n  (:start . 174) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 186)\n  (:start . 181) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 192) (:start . 190)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "epo-dependent") (:form . "Epo-dependent")\n  (:end . 206) (:start . 193) (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 212)\n  (:start . 207) (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 217) (:start . 213)\n  (:id . 79))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 222) (:start . 218)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 228) (:start . 224)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 232) (:start . 229)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s274.3) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002477@unknown@formal@none@1@S@The results were compared to those obtained with the parental granulocyte-macrophage colony-stimulating factor ( GM-CSF ) -dependent cell line, UT-7, which has a predominantly megakaryoblastic phenotype and is unable to proliferate continuously in the presence of Epo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 84) (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 103) (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 119)\n  (:start . 113) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "-dependent") (:form . "-dependent") (:end . 132)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 142) (:start . 138)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 175) (:start . 162) (:id . 67))\n ((:tag . "JJ") (:stem . "megakaryoblastic") (:form . "megakaryoblastic")\n  (:end . 192) (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 202)\n  (:start . 193) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 209) (:start . 207)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 216)\n  (:start . 210) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 73))\n ((:tag . "VB") (:stem . "proliferate") (:form . "proliferate") (:end . 231)\n  (:start . 220) (:id . 74))\n ((:tag . "RB") (:stem . "continuously") (:form . "continuously") (:end . 244)\n  (:start . 232) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 251) (:start . 248)\n  (:id . 77))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 260)\n  (:start . 252) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 263) (:start . 261)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 267) (:start . 264)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x274.4.1) (:span 210 216)))\n (:nscopes ((:id . :x274.4.1) (:span 210 267)))\n (:identifiers (:sid . :s274.4) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002478@unknown@formal@none@1@S@UT-7 Epo and UT-7 expressed similar levels of GATA-1 mRNA and binding activity.@(((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s274.5) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002480@unknown@formal@none@1@S@13,800 ± 300).@(((:tag . "CD") (:stem . "13,800") (:form . "13,800") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "CD") (:stem . "300") (:form . "300") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 14) (:start . 13)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s274.7) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002481@unknown@formal@none@1@S@This difference in the number of binding sites could be due to differences in cell surface (UT-7 cells are 20 % smaller than the parental UT-7 cells) or in receptor turnover.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ut-7") (:form . "UT-7") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 119)\n  (:start . 112) (:id . 64))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "NN") (:stem . "ut-7") (:form . "UT-7") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 152) (:start . 150)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 164)\n  (:start . 156) (:id . 73))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 173)\n  (:start . 165) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x274.8.1) (:span 47 52)))\n (:hscopes ((:id . :x274.8.1) (:span 47 173)))\n (:identifiers (:sid . :s274.8) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002482@unknown@formal@none@1@S@By Northern analysis, UT-7 cells expressed detectable levels of beta- and gamma-globin but not alpha-globin.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta-") (:form . "beta-") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha-globin") (:form . "alpha-globin") (:end . 107)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x274.9.1) (:span 91 94)))\n (:nscopes ((:id . :x274.9.1) (:span 91 107)))\n (:identifiers (:sid . :s274.9) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002483@unknown@formal@none@1@S@In comparison, UT-7 Epo cells expressed alpha-globin and higher levels of gamma-globin (5-fold) and beta-globin (from barely to clearly detectable).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "alpha-globin") (:form . "alpha-globin") (:end . 52)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 63) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "5-fold") (:form . "5-fold") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 111)\n  (:start . 100) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "RB") (:stem . "barely") (:form . "barely") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s274.10) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002484@unknown@formal@none@1@S@Globin chains (alpha, beta and gamma) were clearly detectable by affinity chromatography in UT-7 Epo but not in UT-7 cells.@(((:tag . "NNP") (:stem . "Globin") (:form . "Globin") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 50)\n  (:start . 43) (:id . 52))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 88) (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "UT-7") (:form . "UT-7") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ut-7") (:form . "UT-7") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x274.11.1) (:span 105 108)))\n (:nscopes ((:id . :x274.11.1) (:span 105 122)))\n (:identifiers (:sid . :s274.11) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002485@unknown@formal@none@1@S@The frequency of the cells which expressed beta- and gamma-globin genes in the two cell populations was measured by immunofluorescence with beta- and gamma-specific antibodies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "beta-") (:form . "beta-") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 134) (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "beta-") (:form . "beta-") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "gamma-specific") (:form . "gamma-specific")\n  (:end . 164) (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 175)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s274.12) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002486@unknown@formal@none@1@S@The number of gamma-positive cells and their fluorescence intensity were higher in UT-7 Epo than in UT-7 cells (0 to 17% barely positive cells and 23 to 40% clearly positive cells, respectively) , indicating that the increase in globin mRNA observed in UT-7 Epo is due to both an increase of gene expression per cell and an increase in numbers of cells containing gamma-globin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "gamma-positive") (:form . "gamma-positive")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . 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5002487@unknown@formal@none@1@S@The levels of GATA-1, Epo-R and globin mRNA expressed were not affected by a 24-hour incubation of either cell line with Epo, GM-CSF or interleukin-3 (IL-3).(ABSTRACT TRUNCATED AT 400 WORDS)@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "epo-r") (:form . "Epo-R") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "24-hour") (:form . "24-hour") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 132)\n  (:start . 126) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "interleukin-3") (:form . "interleukin-3")\n  (:end . 149) (:start . 136) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IL-3).(ABSTRACT") (:form . "IL-3).(ABSTRACT")\n  (:end . 166) (:start . 151) (:id . 70))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 176)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x274.14.1) (:span 133 135)))\n (:ncues ((:id . :x274.14.2) (:span 99 105))\n  ((:id . :x274.14.3) (:span 59 62)))\n (:hscopes ((:id . :x274.14.1) (:span 121 156)))\n (:nscopes ((:id . :x274.14.2) (:span 99 115))\n  ((:id . :x274.14.3) (:span 0 156)))\n (:identifiers (:sid . :s274.14) (:did . :|93292612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002488@unknown@formal@none@1@S@Transcriptional activation of the macrophage colony-stimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony-stimulating factor protein by monocytes and involves activation of the transcription factor NF-kappa B.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 63) (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 83) (:start . 79)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 97)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "bioactive") (:form . "bioactive") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 136)\n  (:start . 126) (:id . 58))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 155) (:start . 137) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 162)\n  (:start . 156) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 170)\n  (:start . 163) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 183)\n  (:start . 174) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 196)\n  (:start . 188) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 207)\n  (:start . 197) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 228) (:start . 215) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 235)\n  (:start . 229) (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 244)\n  (:start . 236) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 246) (:start . 245)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s275.1) (:did . :|93294310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002490@unknown@formal@none@1@S@Here we report that binding of human IL-2 to its binding site leads to transcriptional activation of the macrophage CSF (M-CSF) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity-stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . 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5002491@unknown@formal@none@1@S@Transcriptional activation of the M-CSF gene by IL-2 is preceded by enhanced binding activity of the transcription factor NF-kappa B to its recognition sequence in the 5' regulatory enhancer region of the M-CSF gene.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "precede") (:form . "preceded") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 190)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 197)\n  (:start . 191) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 210)\n  (:start . 205) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 215) (:start . 211)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s275.4) (:did . :|93294310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002492@unknown@formal@none@1@S@Moreover, using a heterologous promoter (herpes thymidine kinase) construct containing the NF-kappa B consensus sequence, it is shown that NF-kappa B binding by an IL-2-induced monocyte-derived nuclear protein confers reporter gene (human growth hormone) activity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "herpes") (:form . "herpes") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 176)\n  (:start . 164) (:id . 70))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 193) (:start . 177) (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 209)\n  (:start . 202) (:id . 73))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 217)\n  (:start . 210) (:id . 74))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 226)\n  (:start . 218) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 231) (:start . 227)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 238)\n  (:start . 233) (:id . 78))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 245)\n  (:start . 239) (:id . 79))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 253)\n  (:start . 246) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 254) (:start . 253)\n  (:id . 81))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 263)\n  (:start . 255) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s275.5) (:did . :|93294310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002493@unknown@formal@none@1@S@Taken together, our findings indicate that IL-2 induces gene expression of M-CSF in human blood-derived Mo and provide evidence for involvement of NF-kappa B in transcriptional regulation of this gene.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "blood-derived") (:form . "blood-derived")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "Mo") (:form . "Mo") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 176) (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 195) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 200) (:start . 196)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x275.6.1) (:span 29 42)))\n (:hscopes ((:id . :x275.6.1) (:span 29 106)))\n (:identifiers (:sid . :s275.6) (:did . :|93294310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002494@unknown@formal@none@1@S@Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes.@(((:tag . "JJ") (:stem . "comparative") (:form . "Comparative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 103)\n  (:start . 92) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s276.1) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002495@unknown@formal@none@1@S@Nuclear factor of activated T cells (NFAT) is a transcriptional activator that binds to sequences in the interleukin-2 (IL-2) promoter and is thought to be largely responsible for the T cell-specific inducibility of IL-2 expression.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 63) (:start . 48) (:id . 53))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 118) (:start . 105) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 149)\n  (:start . 142) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 163)\n  (:start . 156) (:id . 71))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 175)\n  (:start . 164) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 199) (:start . 186) (:id . 76))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 212)\n  (:start . 200) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 220) (:start . 216)\n  (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 231)\n  (:start . 221) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x276.2.1) (:span 142 149)))\n (:hscopes ((:id . :x276.2.1) (:span 139 231)))\n (:identifiers (:sid . :s276.2) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002496@unknown@formal@none@1@S@Electrophoretic mobility shift assays (EMSA) showed that specific NFAT binding activity could also be induced in human B cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 51) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x276.3.1) (:span 88 93)))\n (:hscopes ((:id . :x276.3.1) (:span 57 126)))\n (:identifiers (:sid . :s276.3) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002497@unknown@formal@none@1@S@The B cell NFAT complex, however, was not functional, since it failed to activate transcription from an NFAT-driven chloramphenicol acetyltransferase (CAT) construct.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 52)\n  (:start . 42) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 59) (:start . 54)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 62) (:start . 60)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 69) (:start . 63)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 81)\n  (:start . 73) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nfat-driven") (:form . "NFAT-driven") (:end . 115)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 131) (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 149) (:start . 132) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 165)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x276.4.1) (:span 63 69)) ((:id . :x276.4.2) (:span 38 41)))\n (:nscopes ((:id . :x276.4.1) (:span 63 165))\n  ((:id . :x276.4.2) (:span 38 52)))\n (:identifiers (:sid . :s276.4) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002498@unknown@formal@none@1@S@Competition with an AP-1 motif or with anti-Jun and anti-Fos antibodies abolished binding to the NFAT motif in both T and B cells, indicating that Jun and Fos are critical for NFAT complex formation in both cell types.@(((:tag . "NN") (:stem . "competition") (:form . "Competition") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-jun") (:form . "anti-Jun") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-fos") (:form . "anti-Fos") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 162) (:start . 159)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 171)\n  (:start . 163) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 180) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 188)\n  (:start . 181) (:id . 75))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 198)\n  (:start . 189) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 77))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 206) (:start . 202)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 211) (:start . 207)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 217)\n  (:start . 212) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x276.5.1) (:span 131 146)))\n (:hscopes ((:id . :x276.5.1) (:span 131 217)))\n (:identifiers (:sid . :s276.5) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002500@unknown@formal@none@1@S@However, when combined with unstimulated B or T cell extracts, full-length, but not truncated, Jun/Fos heterodimers were able to form an NFAT complex, indicating the presence of a constitutively expressed nuclear factor ( s ) in B and T cells necessary for the formation of the NFAT complex in both cell types.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "b") (:form . 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5002501@unknown@formal@none@1@S@An NFAT oligonucleotide carrying mutations in the 5' purine-rich part of the NFAT sequence failed to form a complex and to compete with the wild type motif for NFAT complex formation in both T and B cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 23) (:start . 8) (:id . 44))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 97) (:start . 91)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 164) (:start . 160)\n  (:id . 71))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 172)\n  (:start . 165) (:id . 72))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 182)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 74))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 190) (:start . 186)\n  (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 192) (:start . 191)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 77))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 198) (:start . 197)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x276.8.1) (:span 91 97)))\n (:nscopes ((:id . :x276.8.1) (:span 91 204)))\n (:identifiers (:sid . :s276.8) (:did . :|93300824|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002502@unknown@formal@none@1@S@We therefore propose a model whereby a core NFAT complex consisting of Jun, Fos, and a constitutive nuclear factor is formed in both T and B cells, but an additional factor and/or post-translational modification of a factor, missing in B cells, might be required for transactivation by NFAT.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . 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5002503@unknown@formal@none@1@S@1,25-Dihydroxy vitamin D3 and 12-O-tetradecanoyl phorbol-13-acetate synergistically induce monocytic cell differentiation: FOS and RB expression.@(((:tag . "NNP") (:stem . "1,25-Dihydroxy") (:form . "1,25-Dihydroxy")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 22)\n  (:start . 15) (:id . 43))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoyl") (:form . "12-O-tetradecanoyl")\n  (:end . 48) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "phorbol-13-acetate") (:form . "phorbol-13-acetate")\n  (:end . 67) (:start . 49) (:id . 47))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 83) (:start . 68) (:id . 48))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 90)\n  (:start . 84) (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 100)\n  (:start . 91) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 121) (:start . 106) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 122) (:start . 121)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 126) (:start . 123)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RB") (:form . "RB") (:end . 133) (:start . 131)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s277.1) (:did . :|93300929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002504@unknown@formal@none@1@S@1,25-dihydroxy vitamin D3 and 12-O-tetradecanoyl phorbol-13-acetate (TPA) interact synergistically to induce monocytic differentiation of U937 histiocytic lymphoma cells.@(((:tag . "JJ") (:stem . "1,25-dihydroxy") (:form . "1,25-dihydroxy")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 22)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoyl") (:form . "12-O-tetradecanoyl")\n  (:end . 48) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "phorbol-13-acetate") (:form . "phorbol-13-acetate")\n  (:end . 67) (:start . 49) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 72) (:start . 69)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 98) (:start . 83) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 108)\n  (:start . 102) (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 118)\n  (:start . 109) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 134) (:start . 119) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 142) (:start . 138)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "histiocytic") (:form . "histiocytic") (:end . 154)\n  (:start . 143) (:id . 59))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 163)\n  (:start . 155) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 169)\n  (:start . 164) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s277.2) (:did . :|93300929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002505@unknown@formal@none@1@S@Addition of TPA causes an otherwise ineffective dose of 1,25-dihydroxy vitamin D3 to induce differentiation.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "otherwise") (:form . "otherwise") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "1,25-dihydroxy") (:form . "1,25-dihydroxy")\n  (:end . 70) (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 107) (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s277.3) (:did . :|93300929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002506@unknown@formal@none@1@S@The induced differentiation depends on the simultaneous ( vs. sequential) presence of both agents.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 27) (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "IN") (:stem . "vs.") (:form . "vs.") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sequential") (:form . "sequential") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s277.4) (:did . :|93300929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002507@unknown@formal@none@1@S@The kinetics of induced differentiation are consistent with a G1 specific cellular response to initiate the metabolic cascade culminating in cell differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "VBG") (:stem . "culminate") (:form . "culminating") (:end . 137)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 161) (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s277.5) (:did . :|93300929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002508@unknown@formal@none@1@S@The induced differentiation occurs with down-regulation of c-fos protein and an accompanying up-regulation of RB protein expression, consistent with a possible need for up-regulated RB expression to maintain a given differentiated phenotype and suppress transcriptional activators that might typically be associated with proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 27) (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 55) (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . 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(:end . 335) (:start . 334)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x277.6.1) (:span 286 291))\n  ((:id . :x277.6.2) (:span 151 159)) ((:id . :x277.6.3) (:span 133 148)))\n (:hscopes ((:id . :x277.6.1) (:span 281 334))\n  ((:id . :x277.6.2) (:span 151 334)) ((:id . :x277.6.3) (:span 133 334)))\n (:identifiers (:sid . :s277.6) (:did . :|93300929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002510@unknown@formal@none@1@S@The enhancer for the immunoglobulin mu heavy chain gene (IgH) activates a heterologous gene at the pre-B cell stage of B lymphocyte differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 35) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 86)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 131)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 147) (:start . 132) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s278.2) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002511@unknown@formal@none@1@S@A lymphoid-specific element, microB, is necessary for enhancer function in pre-B cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 19) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "microB") (:form . "microB") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s278.3) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002512@unknown@formal@none@1@S@A microB binding protein is encoded by the PU.1/Spi-1 proto-oncogene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pu.1/spi-1") (:form . "PU.1/Spi-1") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 68) (:start . 54) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s278.4) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002513@unknown@formal@none@1@S@Another sequence element, microA, was identified in the mu enhancer that binds the product of the ets-1 proto-oncogene.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "microA") (:form . "microA") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ets-1") (:form . "ets-1") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 118) (:start . 104) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s278.5) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002514@unknown@formal@none@1@S@The microA motif was required for microB-dependent enhancer activity, which suggests that a minimal B cell-specific enhancer is composed of both the PU.1 and Ets-1 binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "microa") (:form . "microA") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "microb-dependent") (:form . "microB-dependent")\n  (:end . 50) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x278.6.1) (:span 76 84)))\n (:hscopes ((:id . :x278.6.1) (:span 76 177)))\n (:identifiers (:sid . :s278.6) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002515@unknown@formal@none@1@S@Co-expression of both PU.1 and Ets-1 in nonlymphoid cells trans-activated reporter plasmids that contained the minimal mu enhancer.@(((:tag . "NN") (:stem . "co-expression") (:form . "Co-expression")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "trans-activated") (:form . "trans-activated")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s278.7) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002516@unknown@formal@none@1@S@These results implicate two members of the Ets family in the activation of IgH gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "implicate") (:form . "implicate") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s278.8) (:did . :|93303626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002517@unknown@formal@none@1@S@Differential autoregulation of glucocorticoid receptor expression in human T- and B-cell lines.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 27) (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 45) (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 54)\n  (:start . 46) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-") (:form . "T-") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s279.1) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002518@unknown@formal@none@1@S@Regulation of glucocorticoid receptor (GR) expression by its cognate ligand was examined in the glucocorticoid-sensitive human leukemic T-cell line 6TG1.1 and in the human B-cell line IM-9.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "glucocorticoid-sensitive")\n  (:form . "glucocorticoid-sensitive") (:end . 120) (:start . 96) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 142)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "6tg1.1") (:form . "6TG1.1") (:end . 154)\n  (:start . 148) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 178)\n  (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "NN") (:stem . "im-9") (:form . "IM-9") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s279.2) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002520@unknown@formal@none@1@S@Half-maximal induction of GR mRNA and protein in 6TG1.1 cells was observed between 10-100 nM dexamethasone, and inclusion of 1 microM RU 38486 completely blocked the effects of 100 nM dexamethasone, demonstrating that positive autoregulation of GR expression in 6TG1.1 cells is a receptor-mediated response.@(((:tag . "JJ") (:stem . "half-maximal") (:form . "Half-maximal") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . 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5002521@unknown@formal@none@1@S@Positive autoregulation of GR expression was also observed in glucocorticoid-resistant CEM-C1 cells, which contain functional GR, but whose growth is unaffected by glucocorticoids.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 23) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "glucocorticoid-resistant")\n  (:form . "glucocorticoid-resistant") (:end . 86) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "cem-c1") (:form . "CEM-C1") (:end . 93)\n  (:start . 87) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 114)\n  (:start . 107) (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 125)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 179) (:start . 164) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s279.5) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002522@unknown@formal@none@1@S@Thus, positive autoregulation is neither a consequence nor the sole cause of growth arrest.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 29) (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sole") (:form . "sole") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x279.6.1) (:span 33 40 55 58)))\n (:nscopes ((:id . :x279.6.1) (:span 33 90)))\n (:identifiers (:sid . :s279.6) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002523@unknown@formal@none@1@S@The degree of negative autoregulation in IM-9 cells and positive autoregulation in 6TG1.1 cells was unaffected by inhibition of protein synthesis with cycloheximide.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IM-9") (:form . "IM-9") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 79) (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "6tg1.1") (:form . "6TG1.1") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 164) (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s279.7) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002524@unknown@formal@none@1@S@Measurement of GR mRNA turnover in 6TG1.1 cells treated with actinomycin-D revealed a half-life of 2.5 h, which was unaffected by dexamethasone treatment.@(((:tag . "NNP") (:stem . "Measurement") (:form . "Measurement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "6tg1.1") (:form . "6TG1.1") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "actinomycin-d") (:form . "actinomycin-D")\n  (:end . 74) (:start . 61) (:id . 52))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "CD") (:stem . "2.5") (:form . "2.5") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 143) (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 153)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s279.8) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002525@unknown@formal@none@1@S@A similar half-life was determined in IM-9 cells and was also unaffected by steroid treatment.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IM-9") (:form . "IM-9") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s279.9) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002526@unknown@formal@none@1@S@These results are consistent with the interpretation that glucocorticoid-mediated autoregulation of GR expression is a tissue-specific primary transcriptional response.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 52) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "glucocorticoid-mediated") (:end . 81) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 96) (:start . 82) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 134) (:start . 119) (:id . 57))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 142)\n  (:start . 135) (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 158) (:start . 143) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 167)\n  (:start . 159) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s279.10) (:did . :|93307152|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002527@unknown@formal@none@1@S@The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s280.1) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002528@unknown@formal@none@1@S@Transcription factor NF-kappa B (p50/p65) is generally localized to the cytoplasm by its inhibitor I kappa B.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s280.2) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002530@unknown@formal@none@1@S@Overexpression of p65 increases endogenous I kappa B protein in both carcinoma and lymphoid cells by two mechanisms: protein stabilization and increased transcription of I kappa B mRNA.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 138) (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 166) (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s280.4) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002531@unknown@formal@none@1@S@In contrast, p65 delta, a naturally occurring splice variant, fails to markedly augment I kappa B protein levels.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 35)\n  (:start . 26) (:id . 49))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s280.5) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002532@unknown@formal@none@1@S@Both overexpressed p65 and coexpressed p50 are cytoplasmic, whereas p65 delta is partly nuclear, indicating that the I kappa B induced by p65 can maintain NF-kappa B in the cytoplasm.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "overexpressed") (:form . "overexpressed")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 182)\n  (:start . 173) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x280.6.1) (:span 97 112)))\n (:hscopes ((:id . :x280.6.1) (:span 97 182)))\n (:identifiers (:sid . :s280.6) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002533@unknown@formal@none@1@S@Thus, p65 and I kappa B are linked in an autoregulatory loop, ensuring that NF-kappa B is held in the cytoplasm until cells are specifically induced to translocate it to the nucleus.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 21) (:start . 16)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 34) (:start . 28)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 55) (:start . 41) (:id . 53))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "ensure") (:form . "ensuring") (:end . 70)\n  (:start . 62) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "hold") (:form . "held") (:end . 94) (:start . 90)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 111)\n  (:start . 102) (:id . 64))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 117)\n  (:start . 112) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 127) (:start . 124)\n  (:id . 67))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 140)\n  (:start . 128) (:id . 68))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 148)\n  (:start . 141) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "VB") (:stem . "translocate") (:form . "translocate") (:end . 163)\n  (:start . 152) (:id . 71))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 74))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s280.7) (:did . :|93307660|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002534@unknown@formal@none@1@S@Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "biochemically") (:form . "biochemically")\n  (:end . 97) (:start . 84) (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s281.1) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002535@unknown@formal@none@1@S@The transcription factor E2F activates the expression of multiple genes involved in cell proliferation, such as c-myc and the dihydrofolate reductase gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 102) (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dihydrofolate") (:form . "dihydrofolate")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "reductase") (:form . "reductase") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s281.2) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002536@unknown@formal@none@1@S@Regulation of E2F involves its interactions with other cellular proteins, including the retinoblastoma protein (Rb), the Rb-related protein p107, cyclin A, and cdk2.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 102) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "rb-related") (:form . "Rb-related") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "p107") (:form . "p107") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cdk2") (:form . "cdk2") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s281.3) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002537@unknown@formal@none@1@S@We undertook a detailed analysis of E2F DNA-binding activities and their cell cycle behavior in primary human T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "undertake") (:form . "undertook") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 72)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "behavior") (:form . "behavior") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s281.4) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002538@unknown@formal@none@1@S@Three E2F DNA-binding activities were identified in resting ( G0 ) T cells with mobilities in gel shift assays distinct from those of previously defined E2F complexes.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "G0") (:form . "G0") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mobility") (:form . "mobilities") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s281.5) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002540@unknown@formal@none@1@S@The most prominent E2F activity in resting T cells (termed complex X) was abundant in both G0 and G1 but disappeared as cells entered S phase, suggesting a possible role in negatively regulating E2F function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 58) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "G0") (:form . "G0") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "disappear") (:form . "disappeared") (:end . 116)\n  (:start . 105) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 66))\n ((:tag . "VBD") (:stem . "enter") (:form . "entered") (:end . 133)\n  (:start . 126) (:id . 67))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 135) (:start . 134)\n  (:id . 68))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 141)\n  (:start . 136) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 153)\n  (:start . 143) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 164)\n  (:start . 156) (:id . 73))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 169) (:start . 165)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 75))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 183)\n  (:start . 173) (:id . 76))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 194)\n  (:start . 184) (:id . 77))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 198) (:start . 195)\n  (:id . 78))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 207)\n  (:start . 199) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x281.7.1) (:span 156 164))\n  ((:id . :x281.7.2) (:span 143 153)))\n (:hscopes ((:id . :x281.7.1) (:span 156 207))\n  ((:id . :x281.7.2) (:span 143 207)))\n (:identifiers (:sid . :s281.7) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002541@unknown@formal@none@1@S@Complex X could be dissociated by adenovirus E1A with a requirement for an intact E1A conserved region 2.@(((:tag . "NN") (:stem . "complex") (:form . "Complex") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "dissociate") (:form . "dissociated") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "e1a") (:form . "E1A") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x281.8.1) (:span 10 15)))\n (:hscopes ((:id . :x281.8.1) (:span 0 104)))\n (:identifiers (:sid . :s281.8) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002542@unknown@formal@none@1@S@However, X failed to react with a variety of antibodies against Rb or p107, implicating the involvement of an E1A-binding protein other than Rb or p107.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 17) (:start . 11)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "react") (:form . "react") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 41)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 55)\n  (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p107") (:form . "p107") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 87)\n  (:start . 76) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 103)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "e1a-binding") (:form . "E1A-binding") (:end . 121)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p107") (:form . "p107") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x281.9.1) (:span 76 87)))\n (:ncues ((:id . :x281.9.2) (:span 11 17)))\n (:hscopes ((:id . :x281.9.1) (:span 76 151)))\n (:nscopes ((:id . :x281.9.2) (:span 11 74)))\n (:identifiers (:sid . :s281.9) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002543@unknown@formal@none@1@S@In addition to these novel E2F complexes, three distinct forms of unbound (free) E2F were resolved in gel shift experiments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unbound") (:form . "unbound") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "resolve") (:form . "resolved") (:end . 98)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 111)\n  (:start . 106) (:id . 63))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 123)\n  (:start . 112) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s281.10) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002544@unknown@formal@none@1@S@These species showed different cell cycle kinetics.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 20) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s281.11) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002545@unknown@formal@none@1@S@UV cross-linking experiments suggested that a distinct E2F DNA-binding protein is uniquely associated with the S-phase p107 complex and is not associated with Rb.@(((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 70)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "RB") (:stem . "uniquely") (:form . "uniquely") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "S-phase") (:form . "S-phase") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "p107") (:form . "p107") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 153)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x281.12.2) (:span 29 38)))\n (:ncues ((:id . :x281.12.1) (:span 139 142)))\n (:hscopes ((:id . :x281.12.2) (:span 29 161)))\n (:nscopes ((:id . :x281.12.1) (:span 139 161)))\n (:identifiers (:sid . :s281.12) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002546@unknown@formal@none@1@S@Together, these results suggest that E2F consists of multiple, biochemically distinct DNA-binding proteins which function at different points in the cell cycle.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "biochemically") (:form . "biochemically")\n  (:end . 76) (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x281.13.1) (:span 24 31)))\n (:hscopes ((:id . :x281.13.1) (:span 24 159)))\n (:identifiers (:sid . :s281.13) (:did . :|93309430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002547@unknown@formal@none@1@S@Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.@(((:tag . "NN") (:stem . "occurrence") (:form . "Occurrence") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x282.1.1) (:span 64 67)))\n (:nscopes ((:id . :x282.1.1) (:span 64 106)))\n (:identifiers (:sid . :s282.1) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002548@unknown@formal@none@1@S@In the immune system the first activation of a naive T cell by antigen is a key step in the shaping of the peripheral T cell specificity repertoire and maintenance of self-tolerance.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 84) (:start . 80)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 61))\n ((:tag . "NN") (:stem . "shaping") (:form . "shaping") (:end . 99)\n  (:start . 92) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 117)\n  (:start . 107) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 67))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 136)\n  (:start . 125) (:id . 68))\n ((:tag . "NN") (:stem . "repertoire") (:form . "repertoire") (:end . 147)\n  (:start . 137) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 163)\n  (:start . 152) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "self-tolerance") (:form . "self-tolerance")\n  (:end . 181) (:start . 167) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s282.2) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002550@unknown@formal@none@1@S@By contrast, memory cells, either in vitro activated helper T cells reverting to a resting state, or CD4+ T ( memory ) clones, or CD4+CD45RO+ T cells isolated ex vivo, no longer have a silencer.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "revert") (:form . "reverting") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "resting") (:form . "resting") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 105) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 64))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 116)\n  (:start . 110) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 125)\n  (:start . 119) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cd4+cd45ro+") (:form . "CD4+CD45RO+") (:end . 141)\n  (:start . 130) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 143) (:start . 142)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 72))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 158)\n  (:start . 150) (:id . 73))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 161) (:start . 159)\n  (:id . 74))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 166) (:start . 162)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 76))\n ((:tag . "RB") (:stem . "no") (:form . "no") (:end . 170) (:start . 168)\n  (:id . 77))\n ((:tag . "RB") (:stem . "longer") (:form . "longer") (:end . 177)\n  (:start . 171) (:id . 78))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 182) (:start . 178)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 80))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 193)\n  (:start . 185) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x282.4.1) (:span 168 177)))\n (:nscopes ((:id . :x282.4.1) (:span 168 193)))\n (:identifiers (:sid . :s282.4) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002551@unknown@formal@none@1@S@Their IL-2 transcription seems to be controlled solely by the transition from inactive to active functional state of a positive transcription factor binding to these promoter elements as well as its cytoplasmic or nuclear location:@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "RB") (:stem . "solely") (:form . "solely") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 183)\n  (:start . 175) (:id . 68))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 186) (:start . 184)\n  (:id . 69))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 198) (:start . 195)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 210)\n  (:start . 199) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 221)\n  (:start . 214) (:id . 75))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 230)\n  (:start . 222) (:id . 76))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 231) (:start . 230)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x282.5.1) (:span 25 30)))\n (:hscopes ((:id . :x282.5.1) (:span 0 230)))\n (:identifiers (:sid . :s282.5) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002552@unknown@formal@none@1@S@in resting memory T cells the activator is located in the cytoplasm and is inactive, whereas in stimulated cells it is functional in promoting transcription and now resides in the nucleus.@(((:tag . "IN") (:stem . "in") (:form . "in") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 10) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 156) (:start . 143) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "reside") (:form . "resides") (:end . 172)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 187)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s282.6) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002553@unknown@formal@none@1@S@Thus, the regulation of the gene coding for the main T cell growth factor changes irreversibly after the first encounter of T cells with antigen.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 39) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 66)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "RB") (:stem . "irreversibly") (:form . "irreversibly") (:end . 94)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "encounter") (:form . "encounter") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 144)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s282.7) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002554@unknown@formal@none@1@S@It is most likely that the presence of a silencer contributes to the more stringent activation requirements of naive CD4+ T cells.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "stringent") (:form . "stringent") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x282.8.1) (:span 11 17)))\n (:hscopes ((:id . :x282.8.1) (:span 11 129)))\n (:identifiers (:sid . :s282.8) (:did . :|93314685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002555@unknown@formal@none@1@S@Single strand conformation polymorphism analysis of androgen receptor gene mutations in patients with androgen insensitivity syndromes: application for diagnosis, genetic counseling, and therapy.@(((:tag . "JJ") (:stem . "single") (:form . "Single") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 39)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 124) (:start . 111) (:id . 56))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 134)\n  (:start . 125) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 135) (:start . 134)\n  (:id . 58))\n ((:tag . "NN") (:stem . "application") (:form . "application") (:end . 147)\n  (:start . 136) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 60))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 161)\n  (:start . 152) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 170)\n  (:start . 163) (:id . 63))\n ((:tag . "NN") (:stem . "counseling") (:form . "counseling") (:end . 181)\n  (:start . 171) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 66))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 194)\n  (:start . 187) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s283.1) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002556@unknown@formal@none@1@S@Recent studies indicate that mutations in the androgen receptor gene are associated with androgen insensitivity syndromes, a heterogeneous group of related disorders involving defective sexual differentiation in karyotypic males.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 111) (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 138) (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 155)\n  (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 175)\n  (:start . 166) (:id . 65))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 185)\n  (:start . 176) (:id . 66))\n ((:tag . "JJ") (:stem . "sexual") (:form . "sexual") (:end . 192)\n  (:start . 186) (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 208) (:start . 193) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "karyotypic") (:form . "karyotypic") (:end . 222)\n  (:start . 212) (:id . 70))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 228)\n  (:start . 223) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x283.2.1) (:span 15 28)))\n (:hscopes ((:id . :x283.2.1) (:span 15 228)))\n (:identifiers (:sid . :s283.2) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002557@unknown@formal@none@1@S@In this report, we address the possibility of rapid mutational analysis of the androgen receptor gene for initial diagnosis, genetic counseling, and molecular subclassification of affected patients and their families.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "address") (:form . "address") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 42)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mutational") (:form . "mutational") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "counseling") (:form . "counseling") (:end . 143)\n  (:start . 133) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "subclassification") (:form . "subclassification")\n  (:end . 176) (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 197)\n  (:start . 189) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 207)\n  (:start . 202) (:id . 73))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 216)\n  (:start . 208) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s283.3) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002558@unknown@formal@none@1@S@DNA from peripheral blood leukocytes of six patients from five families with various degrees of androgen insensitivity was studied.@(((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 118) (:start . 105) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s283.4) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002560@unknown@formal@none@1@S@Female family members were also studied to identify heterozygote carriers.@(((:tag . "JJ") (:stem . "female") (:form . "Female") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "heterozygote") (:form . "heterozygote") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "carrier") (:form . "carriers") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s283.6) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002561@unknown@formal@none@1@S@Point mutations in the AR gene were identified in all six patients, and all mutations caused amino acid substitutions.@(((:tag . "NNP") (:stem . "Point") (:form . "Point") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AR") (:form . "AR") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 117) (:start . 104) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s283.7) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002562@unknown@formal@none@1@S@One patient with incomplete androgen insensitivity was a mosaic for the mutation.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 50) (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mosaic") (:form . "mosaic") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s283.8) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002563@unknown@formal@none@1@S@Four of the five mothers, as well as a young sister of one patient, were carriers of the mutation present in the affected child.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mother") (:form . "mothers") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 44) (:start . 39)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sister") (:form . "sister") (:end . 51)\n  (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 58) (:start . 55)\n  (:id . 55))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 66)\n  (:start . 59) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 72) (:start . 68)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "carrier") (:form . "carriers") (:end . 81)\n  (:start . 73) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 97)\n  (:start . 89) (:id . 62))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 105)\n  (:start . 98) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 121)\n  (:start . 113) (:id . 66))\n ((:tag . "NN") (:stem . "child") (:form . "child") (:end . 127)\n  (:start . 122) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s283.9) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002564@unknown@formal@none@1@S@Our data show that new mutations may occur in the androgen receptor gene leading to sporadic androgen insensitivity syndrome.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sporadic") (:form . "sporadic") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x283.10.1) (:span 33 36)))\n (:hscopes ((:id . :x283.10.1) (:span 33 124)))\n (:identifiers (:sid . :s283.10) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002565@unknown@formal@none@1@S@Molecular genetic characterization of the variant allele can serve as a primary tool for diagnosis and subsequent therapy, and can provide a basis for distinguishing heterozygous carriers in familial androgen resistance.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 34) (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "distinguish") (:form . "distinguishing")\n  (:end . 165) (:start . 151) (:id . 67))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 178)\n  (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "carrier") (:form . "carriers") (:end . 187)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "familial") (:form . "familial") (:end . 199)\n  (:start . 191) (:id . 71))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 208)\n  (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 219)\n  (:start . 209) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x283.11.1) (:span 127 130))\n  ((:id . :x283.11.2) (:span 57 60)))\n (:hscopes ((:id . :x283.11.1) (:span 127 219))\n  ((:id . :x283.11.2) (:span 57 121)))\n (:identifiers (:sid . :s283.11) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002566@unknown@formal@none@1@S@The identification of carriers is of substantial clinical importance for genetic counseling.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "carrier") (:form . "carriers") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "counseling") (:form . "counseling") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s283.12) (:did . :|93315600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002567@unknown@formal@none@1@S@Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.@(((:tag . "RB") (:stem . "minimally") (:form . "Minimally") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "lipoprotein-induced")\n  (:form . "lipoprotein-induced") (:end . 50) (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 63)\n  (:start . 51) (:id . 47))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 73)\n  (:start . 64) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 88)\n  (:start . 77) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 98) (:start . 95)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 117)\n  (:start . 111) (:id . 55))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 127)\n  (:start . 118) (:id . 56))\n ((:tag . "NN") (:stem . "monophosphate") (:form . "monophosphate")\n  (:end . 141) (:start . 128) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s284.1) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002568@unknown@formal@none@1@S@We have previously shown that minimally oxidized LDL (MM-LDL) activated endothelial cells to increase their interaction with monocytes but not neutrophils, inducing monocyte but not neutrophil binding and synthesis of monocyte chemotactic protein-1 and monocyte colony-stimulating factor (M-CSF).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "minimally") (:form . "minimally") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MM-LDL") (:form . "MM-LDL") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 154)\n  (:start . 143) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 192)\n  (:start . 182) (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 72))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 214)\n  (:start . 205) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 226)\n  (:start . 218) (:id . 75))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 238)\n  (:start . 227) (:id . 76))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 248)\n  (:start . 239) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 252) (:start . 249)\n  (:id . 78))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 261)\n  (:start . 253) (:id . 79))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 280) (:start . 262) (:id . 80))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 287)\n  (:start . 281) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 289) (:start . 288)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 294)\n  (:start . 289) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 295) (:start . 294)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x284.2.1) (:span 178 181))\n  ((:id . :x284.2.2) (:span 139 142)))\n (:nscopes ((:id . :x284.2.1) (:span 178 192))\n  ((:id . :x284.2.2) (:span 139 154)))\n (:identifiers (:sid . :s284.2) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002570@unknown@formal@none@1@S@Both induction of monocyte binding and mRNA levels for M-CSF by MM-LDL were not inhibited in protein kinase C-depleted endothelial cells.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MM-LDL") (:form . "MM-LDL") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "c-depleted") (:form . "C-depleted") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x284.4.1) (:span 76 79)))\n (:nscopes ((:id . :x284.4.1) (:span 0 136)))\n (:identifiers (:sid . :s284.4) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002571@unknown@formal@none@1@S@A number of our studies indicate that cAMP is the second messenger for the effects of MM-LDL cited above.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "MM-LDL") (:form . "MM-LDL") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "VBD") (:stem . "cite") (:form . "cited") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "above") (:form . "above") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x284.5.1) (:span 24 37)))\n (:hscopes ((:id . :x284.5.1) (:span 24 104)))\n (:identifiers (:sid . :s284.5) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002572@unknown@formal@none@1@S@Incubation of endothelial cells with MM- LDL caused a 173% increase in intracellular cAMP levels.@(((:tag . "NN") (:stem . "incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MM-") (:form . "MM-") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "CD") (:stem . "173") (:form . "173") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 84) (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s284.6) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002573@unknown@formal@none@1@S@Agents which increased cAMP levels, including cholera toxin, pertussis toxin, dibutyryl cAMP, and isoproterenol mimicked the actions of MM-LDL.@(((:tag . "NNS") (:stem . "agent") (:form . "Agents") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "cholera") (:form . "cholera") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pertussis") (:form . "pertussis") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "isoproterenol") (:form . "isoproterenol")\n  (:end . 111) (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "mimic") (:form . "mimicked") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MM-LDL") (:form . "MM-LDL") (:end . 142)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s284.7) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002574@unknown@formal@none@1@S@Agents which elevated cAMP were also shown to activate NF kappa B, suggesting a role for this transcription factor in activation of monocyte-endothelial interactions.@(((:tag . "NNS") (:stem . "agent") (:form . "Agents") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "elevate") (:form . "elevated") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 77)\n  (:start . 67) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "monocyte-endothelial")\n  (:form . "monocyte-endothelial") (:end . 152) (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 165)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x284.8.1) (:span 67 77)))\n (:hscopes ((:id . :x284.8.1) (:span 67 165)))\n (:identifiers (:sid . :s284.8) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002575@unknown@formal@none@1@S@Although endothelial leukocyte adhesion molecule (ELAM) mRNA synthesis can be regulated by NF kappa B, ELAM was not expressed and ELAM mRNA was only slightly elevated in response to MM-LDL.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ELAM") (:form . "ELAM") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ELAM") (:form . "ELAM") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "ELAM") (:form . "ELAM") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 178)\n  (:start . 170) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "MM-LDL") (:form . "MM-LDL") (:end . 188)\n  (:start . 182) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x284.9.2) (:span 71 74)))\n (:ncues ((:id . :x284.9.1) (:span 112 115)))\n (:hscopes ((:id . :x284.9.2) (:span 9 101)))\n (:nscopes ((:id . :x284.9.1) (:span 103 125)))\n (:identifiers (:sid . :s284.9) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002576@unknown@formal@none@1@S@We present evidence that induction of neutrophil binding by LPS is actually suppressed by agents that elevated cAMP levels.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "RB") (:stem . "actually") (:form . "actually") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "elevate") (:form . "elevated") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s284.10) (:did . :|93315684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002577@unknown@formal@none@1@S@Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes.@(((:tag . "JJ") (:stem . "antisense") (:form . "Antisense") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 26) (:start . 10) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 130) (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 149)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s285.1) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002578@unknown@formal@none@1@S@NF-kappa B is a pleiotropic regulator of a variety of genes implicated in the cellular response to injury.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s285.2) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002580@unknown@formal@none@1@S@Antisense phosphorothioate oligonucleotides to the p50 and p65 subunits of the NF-kappa B complex were used to define the physiologic role of this transcription factor in resting and stimulated granulocytes.@(((:tag . "JJ") (:stem . "antisense") (:form . "Antisense") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 26) (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 43) (:start . 27) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 133)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 160) (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 206)\n  (:start . 194) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s285.4) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002581@unknown@formal@none@1@S@A reduction in the expression of p65 was produced by treatment with the phosphorothioate antisense oligodeoxynucleotide.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 88) (:start . 72) (:id . 55))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "oligodeoxynucleotide")\n  (:form . "oligodeoxynucleotide") (:end . 119) (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s285.5) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002582@unknown@formal@none@1@S@This reduction was accompanied by rapid changes in the cellular adhesion of dimethyl sulfoxide-differentiated HL-60 leukemia cells stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dimethyl") (:form . "dimethyl") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "sulfoxide-differentiated")\n  (:form . "sulfoxide-differentiated") (:end . 109) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 141)\n  (:start . 131) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol")\n  (:form . "12-O-tetradecanoylphorbol") (:end . 170) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 181)\n  (:start . 171) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 186) (:start . 183)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s285.6) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002583@unknown@formal@none@1@S@These effects were characterized by a marked reduction in CD11b integrin expression on the surface of treated cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s285.7) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002584@unknown@formal@none@1@S@Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "oligomer") (:form . "oligomer") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 77)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "formyl-met-leu-phe") (:form . "formyl-met-leu-phe")\n  (:end . 126) (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s285.8) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002585@unknown@formal@none@1@S@However, the p65 antisense phosphorothioate oligodeoxynucleotide had no significant effect on the production of reactive oxygen intermediates or on phagocytosis by these cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 43) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "oligodeoxynucleotide")\n  (:form . "oligodeoxynucleotide") (:end . 64) (:start . 44) (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 68) (:start . 65)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 83)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 90)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 120)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 141) (:start . 128) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 147) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phagocytosis") (:form . "phagocytosis") (:end . 160)\n  (:start . 148) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 169)\n  (:start . 164) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x285.9.1) (:span 69 71)))\n (:nscopes ((:id . :x285.9.1) (:span 69 175)))\n (:identifiers (:sid . :s285.9) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002586@unknown@formal@none@1@S@These findings indicate that antisense oligomers to p65 can be used to define the role of NF-kappa B in the activation pathways of neutrophils.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "oligomer") (:form . "oligomers") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 142)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x285.10.1) (:span 56 59))\n  ((:id . :x285.10.2) (:span 15 28)))\n (:hscopes ((:id . :x285.10.1) (:span 29 142))\n  ((:id . :x285.10.2) (:span 15 142)))\n (:identifiers (:sid . :s285.10) (:did . :|93320446|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002587@unknown@formal@none@1@S@Costimulation of cAMP and protein kinase C pathways inhibits the CD3-dependent T cell activation and leads to a persistent expression of the AP-1 transcription factor.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd3-dependent") (:form . "CD3-dependent")\n  (:end . 78) (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 159) (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 166)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s286.1) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002588@unknown@formal@none@1@S@The effects mediated by a combined stimulation of cAMP- and protein kinase C ( PKC ) -dependent pathways have been investigated in different cellular systems, and it has been shown that they may complement each other in activating cell proliferation and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "camp-") (:form . "cAMP-") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "-dependent") (:form . "-dependent") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 127)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 180)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 73))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 190) (:start . 186)\n  (:id . 74))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 194) (:start . 191)\n  (:id . 75))\n ((:tag . "VB") (:stem . "complement") (:form . "complement") (:end . 205)\n  (:start . 195) (:id . 76))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 210) (:start . 206)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 216)\n  (:start . 211) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 230)\n  (:start . 220) (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 235) (:start . 231)\n  (:id . 81))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 249) (:start . 236) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 253) (:start . 250)\n  (:id . 83))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 269) (:start . 254) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x286.2.1) (:span 191 194)))\n (:hscopes ((:id . :x286.2.1) (:span 191 269)))\n (:identifiers (:sid . :s286.2) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002590@unknown@formal@none@1@S@T cells preincubated with phorbol 12-myristate 13-acetate (PMA) and dibutyryl cAMP (Bt2cAMP) displayed a deficient proliferative ability in response to anti-CD3 mAb stimulation, whereas lymphocytes treated individually with either Bt2cAMP or PMA responded comparably to untreated samples.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Bt2cAMP") (:form . "Bt2cAMP") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 176)\n  (:start . 165) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 197)\n  (:start . 186) (:id . 71))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 205)\n  (:start . 198) (:id . 72))\n ((:tag . "RB") (:stem . "individually") (:form . "individually") (:end . 218)\n  (:start . 206) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 230)\n  (:start . 224) (:id . 75))\n ((:tag . "NNP") (:stem . "Bt2cAMP") (:form . "Bt2cAMP") (:end . 238)\n  (:start . 231) (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 241) (:start . 239)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 245) (:start . 242)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 255)\n  (:start . 246) (:id . 79))\n ((:tag . "RB") (:stem . "comparably") (:form . "comparably") (:end . 266)\n  (:start . 256) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 269) (:start . 267)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 279)\n  (:start . 270) (:id . 82))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 287)\n  (:start . 280) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s286.4) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002591@unknown@formal@none@1@S@We detected an association between the reduced mitogenic response and low expression of both interleukin-2 (IL-2) and the alpha chain (CD25) of the IL-2 receptor (IL-2R).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd25") (:form . "CD25") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 161)\n  (:start . 153) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 168)\n  (:start . 163) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s286.5) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002592@unknown@formal@none@1@S@Analysis of intracellular Ca2+ mobilization suggested that the CD3/TcR-dependent signal transduction was impaired in PMA/Bt2cAMP-treated cells.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd3/tcr-dependent") (:form . "CD3/TcR-dependent")\n  (:end . 80) (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 87)\n  (:start . 81) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 100)\n  (:start . 88) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 104) (:start . 101)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 113)\n  (:start . 105) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pma/bt2camp-treated")\n  (:form . "PMA/Bt2cAMP-treated") (:end . 136) (:start . 117) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x286.6.1) (:span 44 53)))\n (:hscopes ((:id . :x286.6.1) (:span 44 142)))\n (:identifiers (:sid . :s286.6) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002593@unknown@formal@none@1@S@Remarkably, we observed that these samples displayed a persistent expression of the c-fos protooncogene, associated to an increased AP-1 DNA-binding activity, whereas no variations of CREB or NF-kB were detected.@(((:tag . "RB") (:stem . "remarkably") (:form . "Remarkably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 103) (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "variation") (:form . "variations") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 202) (:start . 198)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 211)\n  (:start . 203) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x286.7.1) (:span 167 169)))\n (:nscopes ((:id . :x286.7.1) (:span 167 211)))\n (:identifiers (:sid . :s286.7) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002594@unknown@formal@none@1@S@Neither Bt2cAMP nor PMA individually mediated these sustained effects, which therefore appear as a consequence of the interplay between both metabolic stimuli.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Bt2cAMP") (:form . "Bt2cAMP") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "individually") (:form . "individually") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x286.8.1) (:span 87 93)))\n (:ncues ((:id . :x286.8.2) (:span 0 7 16 19)))\n (:hscopes ((:id . :x286.8.1) (:span 87 158)))\n (:nscopes ((:id . :x286.8.2) (:span 0 69)))\n (:identifiers (:sid . :s286.8) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002595@unknown@formal@none@1@S@Altogether, the data provide the evidence that both pathways complement each other in regulating gene expression and, conversely, downregulate the TcR transduction mechanisms.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "VBP") (:stem . "complement") (:form . "complement") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "RB") (:stem . "conversely") (:form . "conversely") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "downregulate") (:form . "downregulate")\n  (:end . 142) (:start . 130) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 163)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s286.9) (:did . :|93321228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002596@unknown@formal@none@1@S@Nuclear factor kappa B, a mediator of lipopolysaccharide effects.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 56) (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s287.1) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002597@unknown@formal@none@1@S@Exposure of certain cell types to bacterial lipopolysaccharide (LPS) leads to activation of nuclear factor kappa B (NF-kappa B), an inducible transcription factor.@(((:tag . "NN") (:stem . "exposure") (:form . "Exposure") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 62) (:start . 44) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 155) (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s287.2) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002598@unknown@formal@none@1@S@One of NF-kappa B 's unique properties is its posttranslational activation via release of an inhibitory subunit, called inhibitor of NF-kappa B (I kappa B), from a sequestered cytoplasmic form.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "posttranslational") (:form . "posttranslational")\n  (:end . 63) (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 161) (:start . 157)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "sequester") (:form . "sequestered") (:end . 175)\n  (:start . 164) (:id . 73))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 187)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s287.3) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002600@unknown@formal@none@1@S@Other bacterial toxins, tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), T cell mitogens, UV light, gamma rays and oxidative stress were reported to induce NF-kappa B.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "toxin") (:form . "toxins") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 72) (:start . 59) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 96)\n  (:start . 88) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 106)\n  (:start . 101) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 113)\n  (:start . 108) (:id . 65))\n ((:tag . "NNS") (:stem . "ray") (:form . "rays") (:end . 118) (:start . 114)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 132)\n  (:start . 123) (:id . 68))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 139)\n  (:start . 133) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 144) (:start . 140)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 153)\n  (:start . 145) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 72))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 163)\n  (:start . 157) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 172)\n  (:start . 164) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 174) (:start . 173)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s287.5) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002601@unknown@formal@none@1@S@The activated form of NF-kappa B, which is rapidly taken up into nuclei, initiates transcription from immediate early genes in a wide variety of cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "activated") (:form . "activated") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 82)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s287.6) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002602@unknown@formal@none@1@S@Most of the target genes for NF-kappa B are of relevance for the immune response and can be grouped into those encoding cytokines, cell surface receptors, acute phase proteins and viral genomes, such as that of human immunodeficiency virus type 1 (HIV-1).@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 99)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 129)\n  (:start . 120) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 153)\n  (:start . 144) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 160)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 175)\n  (:start . 167) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 185)\n  (:start . 180) (:id . 74))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 193)\n  (:start . 186) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 202) (:start . 200)\n  (:id . 78))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 207) (:start . 203)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 216)\n  (:start . 211) (:id . 81))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 233) (:start . 217) (:id . 82))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 239)\n  (:start . 234) (:id . 83))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 244) (:start . 240)\n  (:id . 84))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 246) (:start . 245)\n  (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 248) (:start . 247)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 253)\n  (:start . 248) (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 254) (:start . 253)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s287.7) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002603@unknown@formal@none@1@S@We will discuss recent experimental evidences suggesting that LPS might share a pathway of NF-kappa B activation with other inducers of the factor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "discuss") (:form . "discuss") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "evidence") (:form . "evidences") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "VB") (:stem . "share") (:form . "share") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x287.8.1) (:span 66 71)) ((:id . :x287.8.2) (:span 46 56)))\n (:hscopes ((:id . :x287.8.1) (:span 66 146))\n  ((:id . :x287.8.2) (:span 46 146)))\n (:identifiers (:sid . :s287.8) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002604@unknown@formal@none@1@S@This common pathway may involve reactive oxygen intermediates (ROI) as messenger molecules.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 61) (:start . 48) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x287.9.1) (:span 20 23)))\n (:hscopes ((:id . :x287.9.1) (:span 20 90)))\n (:identifiers (:sid . :s287.9) (:did . :|93322080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002605@unknown@formal@none@1@S@Human T cell transcription factor GATA-3 stimulates HIV-1 expression.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s288.1) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002606@unknown@formal@none@1@S@A family of transcriptional activating proteins, the GATA factors, has been shown to bind to a consensus motif through a highly conserved C4 zinc finger DNA binding domain.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "c4") (:form . "C4") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 164)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 171)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s288.2) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002607@unknown@formal@none@1@S@One member of this multigene family, GATA-3, is most abundantly expressed in T lymphocytes, a cellular target for human immunodeficiency virus type 1 (HIV-1) infection and replication.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multigene") (:form . "multigene") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 136) (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 167)\n  (:start . 158) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 183)\n  (:start . 172) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s288.3) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002608@unknown@formal@none@1@S@In vitro DNase I footprinting analysis revealed six hGATA-3 binding sites in the U3 region (the transcriptional regulatory domain) of the HIV-1 LTR.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 111) (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s288.4) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002610@unknown@formal@none@1@S@Further, deletion of the hGATA-3 transcriptional activation domain abolished GATA-dependent HIV-1 trans-activation, showing that the stimulation of viral transcription observed is a direct effect of cotransfected hGATA-3.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 48) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "gata-dependent") (:form . "GATA-dependent")\n  (:end . 91) (:start . 77) (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 114) (:start . 98) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 123)\n  (:start . 116) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 144)\n  (:start . 133) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 153)\n  (:start . 148) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 167) (:start . 154) (:id . 62))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 176)\n  (:start . 168) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 188)\n  (:start . 182) (:id . 66))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 195)\n  (:start . 189) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 212) (:start . 199) (:id . 69))\n ((:tag . "NN") (:stem . "hgata-3") (:form . "hGATA-3") (:end . 220)\n  (:start . 213) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s288.6) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002611@unknown@formal@none@1@S@Introduction of the HIV-1 plasmids in which the GATA sites have been mutated into human T lymphocytes also caused a significant reduction in LTR-mediated transcription at both the basal level and in (PHA- plus PMA-) stimulated T cells.@(((:tag . "NN") (:stem . "introduction") (:form . "Introduction") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 127)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ltr-mediated") (:form . "LTR-mediated") (:end . 153)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 167) (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 200) (:start . 199)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PHA-") (:form . "PHA-") (:end . 204) (:start . 200)\n  (:id . 75))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . "NN") (:stem . "pma-") (:form . "PMA-") (:end . 214) (:start . 210)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 226)\n  (:start . 216) (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 234)\n  (:start . 229) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s288.7) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002612@unknown@formal@none@1@S@These observations suggest that in addition to its normal role in T lymphocyte gene regulation, hGATA-3 may also play a significant role in HIV-1 transcriptional activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "hGATA-3") (:form . "hGATA-3") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 131)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 161) (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x288.8.1) (:span 104 107))\n  ((:id . :x288.8.2) (:span 19 26)))\n (:hscopes ((:id . :x288.8.1) (:span 104 172))\n  ((:id . :x288.8.2) (:span 19 172)))\n (:identifiers (:sid . :s288.8) (:did . :|93324366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002613@unknown@formal@none@1@S@Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "preexisting") (:form . "preexisting") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s289.1) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002614@unknown@formal@none@1@S@The nuclear factor of activated T cells (NF-AT)3 is an inducible DNA-binding protein that is essential for transcriptional induction of the IL-2 gene during T cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-AT)3") (:form . "NF-AT)3") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 122) (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 174)\n  (:start . 164) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s289.2) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002615@unknown@formal@none@1@S@NF-AT is thought to consist of two components: a ubiquitous, inducible nuclear component that we have identified as Fos and Jun proteins, and a preexisting, T cell-specific component (NF-ATp) which is the target for the immunosuppressive agents cyclosporin A (CsA) and FK506.@(((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "consist") (:form . "consist") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "component") (:form . 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")") (:end . 264) (:start . 263)\n  (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 268) (:start . 265)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 274)\n  (:start . 269) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 92)))@@@1@51@((:hcues ((:id . :x289.3.1) (:span 9 16)))\n (:hscopes ((:id . :x289.3.1) (:span 0 45)))\n (:identifiers (:sid . :s289.3) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002616@unknown@formal@none@1@S@We have previously shown that nuclear extracts from activated T cells form two inducible NF-AT complexes with an oligonucleotide corresponding to the distal NF-AT site of the murine IL-2 promoter, although hypotonic extracts of unstimulated T cells form a single complex containing NF-ATp.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 128) (:start . 113) (:id . 60))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 142)\n  (:start . 129) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 156)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 162)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 167) (:start . 163)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 181)\n  (:start . 175) (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 72))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 205)\n  (:start . 197) (:id . 73))\n ((:tag . "JJ") (:stem . "hypotonic") (:form . "hypotonic") (:end . 215)\n  (:start . 206) (:id . 74))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 224)\n  (:start . 216) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 240)\n  (:start . 228) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 242) (:start . 241)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 248)\n  (:start . 243) (:id . 79))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 253) (:start . 249)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 255) (:start . 254)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 262)\n  (:start . 256) (:id . 82))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 270)\n  (:start . 263) (:id . 83))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 281)\n  (:start . 271) (:id . 84))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 288)\n  (:start . 282) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s289.4) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002617@unknown@formal@none@1@S@We show that the ability to detect NF-ATp in a gel shift assay, which is essential for purification and biochemical studies of this protein, is strikingly dependent on the precise sequence of the NF-AT oligonucleotide used as the labeled probe.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 69) (:start . 64)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 82)\n  (:start . 73) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 99)\n  (:start . 87) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 115)\n  (:start . 104) (:id . 62))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "RB") (:stem . "strikingly") (:form . "strikingly") (:end . 154)\n  (:start . 144) (:id . 69))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 164)\n  (:start . 155) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 179)\n  (:start . 172) (:id . 73))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 188)\n  (:start . 180) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 201)\n  (:start . 196) (:id . 77))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 217) (:start . 202) (:id . 78))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 222) (:start . 218)\n  (:id . 79))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 225) (:start . 223)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "label") (:form . "labeled") (:end . 237)\n  (:start . 230) (:id . 82))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 243)\n  (:start . 238) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s289.5) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002618@unknown@formal@none@1@S@Moreover we present evidence that the component that forms the faster-migrating ( " lower " ) nuclear NF-AT complex is derived by a calcium-dependent, cyclosporin-sensitive, posttranslational modification of NF-ATp, and that Fos and Jun proteins stabilize its interaction with DNA.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "faster-migrating") (:form . "faster-migrating")\n  (:end . 79) (:start . 63) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 149) (:start . 132) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cyclosporin-sensitive")\n  (:form . "cyclosporin-sensitive") (:end . 172) (:start . 151) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "posttranslational") (:form . "posttranslational")\n  (:end . 191) (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 204)\n  (:start . 192) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 214)\n  (:start . 208) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 224) (:start . 220)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 228) (:start . 225)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 232) (:start . 229)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 236) (:start . 233)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 245)\n  (:start . 237) (:id . 79))\n ((:tag . "VBP") (:stem . "stabilize") (:form . "stabilize") (:end . 255)\n  (:start . 246) (:id . 80))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 259) (:start . 256)\n  (:id . 81))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 271)\n  (:start . 260) (:id . 82))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 276) (:start . 272)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 280) (:start . 277)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s289.6) (:did . :|93329079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002620@unknown@formal@none@1@S@Enhancing effect of 17 beta-estradiol on human NK cell activity.@(((:tag . "VBG") (:stem . "enhance") (:form . "Enhancing") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-estradiol") (:form . "beta-estradiol")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s290.1) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002621@unknown@formal@none@1@S@The in vitro effect of 17 beta-estradiol on NK activity was studied.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta-estradiol") (:form . "beta-estradiol")\n  (:end . 40) (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s290.2) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002622@unknown@formal@none@1@S@The proliferation and NK activity of YT-N17 (a human NK-like cell line) were enhanced by 17 beta-estradiol (E2), and the enhancement was blocked by tamoxifen (Tx), an antagonist of E2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "YT-N17") (:form . "YT-N17") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nk-like") (:form . "NK-like") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 85)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "beta-estradiol") (:form . "beta-estradiol")\n  (:end . 106) (:start . 92) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "E2") (:form . "E2") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 66))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 132)\n  (:start . 121) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 144)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tamoxifen") (:form . "tamoxifen") (:end . 157)\n  (:start . 148) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Tx") (:form . "Tx") (:end . 161) (:start . 159)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 75))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 166) (:start . 164)\n  (:id . 76))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 177)\n  (:start . 167) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 78))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 183) (:start . 181)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s290.3) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002623@unknown@formal@none@1@S@On the contrary, other steroid hormones such as Tx, progesterone, and testosterone had no effect.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "contrary") (:form . "contrary") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Tx") (:form . "Tx") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 64)\n  (:start . 52) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "testosterone") (:form . "testosterone") (:end . 82)\n  (:start . 70) (:id . 56))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x290.4.1) (:span 87 89)))\n (:nscopes ((:id . :x290.4.1) (:span 87 96)))\n (:identifiers (:sid . :s290.4) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002624@unknown@formal@none@1@S@YT-N17 contained 11.8 fmol/mg protein of estrogen receptor (mean of two independent assays), a value which was 5-10-fold higher than that of other hematopoietic cell lines.@(((:tag . "NNP") (:stem . "YT-N17") (:form . "YT-N17") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "CD") (:stem . "11.8") (:form . "11.8") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fmol/mg") (:form . "fmol/mg") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "RB") (:stem . "5-10-fold") (:form . "5-10-fold") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 160) (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s290.5) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002625@unknown@formal@none@1@S@An enhancement of NK activity by E2 was also seen in large granular lymphocytes obtained from normal subjects, and it was again suppressed by Tx.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "granular") (:form . "granular") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 138)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Tx") (:form . "Tx") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s290.6) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002626@unknown@formal@none@1@S@These data suggest that E2 is one of the activating factors for NK/LGL cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 51)\n  (:start . 41) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nk/lgl") (:form . "NK/LGL") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x290.7.1) (:span 11 18)))\n (:hscopes ((:id . :x290.7.1) (:span 11 76)))\n (:identifiers (:sid . :s290.7) (:did . :|93346062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002627@unknown@formal@none@1@S@Cytokine modulation of HIV expression.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s291.1) (:did . :|93350203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002628@unknown@formal@none@1@S@Cytokines, the peptide hormones which control the homeostasis of the immune system and also play a fundamental role in inflammatory and immune mediated reactions, have been involved at multiple levels in the pathogenesis of the acquired immune deficiency syndrome (AIDS).@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokines") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "fundamental") (:form . "fundamental") (:end . 110)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 131)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 142)\n  (:start . 136) (:id . 64))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 151)\n  (:start . 143) (:id . 65))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 181)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 193)\n  (:start . 185) (:id . 72))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 75))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 220)\n  (:start . 208) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 236)\n  (:start . 228) (:id . 79))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 243)\n  (:start . 237) (:id . 80))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 254)\n  (:start . 244) (:id . 81))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 263)\n  (:start . 255) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 265) (:start . 264)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 269) (:start . 265)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 270) (:start . 269)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s291.2) (:did . :|93350203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002630@unknown@formal@none@1@S@Conversely, several cytokines modulate the levels of HIV expression in infected cells of both T lymphocytic and mononuclear phagocytic lineage.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "phagocytic") (:form . "phagocytic") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s291.4) (:did . :|93350203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002631@unknown@formal@none@1@S@Activated mononuclear cells, particularly B cells which are in a state of chronic activation in HIV infected individuals, release HIV-inductive cytokines and thus play a potentially important role in the pathogenesis of HIV infection.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "JJ") (:stem . "hiv-inductive") (:form . "HIV-inductive")\n  (:end . 143) (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 162) (:start . 158)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 181)\n  (:start . 170) (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 216)\n  (:start . 204) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 223) (:start . 220)\n  (:id . 76))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 233)\n  (:start . 224) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s291.5) (:did . :|93350203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002632@unknown@formal@none@1@S@Tumor necrosis factor receptor expression and signal transduction in HIV-1-infected cells.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 83) (:start . 69) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s292.1) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002633@unknown@formal@none@1@S@OBJECTIVE : To examine the inter-relationship between HIV-1 infection and the cell surface receptors for tumor necrosis factor ( TNF ) -alpha, an immunoregulatory cytokine that can enhance HIV-1 replication.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "To") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inter-relationship") (:form . "inter-relationship")\n  (:end . 45) (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "-alpha") (:form . "-alpha") (:end . 141)\n  (:start . 135) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 162) (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 176) (:start . 172)\n  (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 188)\n  (:start . 181) (:id . 70))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 194)\n  (:start . 189) (:id . 71))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 206)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s292.2) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002634@unknown@formal@none@1@S@DESIGN : Infected promyelocytic and promonocytic cells were examined because they normally express both types of TNF receptors.@(((:tag . "NN") (:stem . "design") (:form . "DESIGN") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "infected") (:form . "Infected") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s292.3) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002635@unknown@formal@none@1@S@METHODS : TNF receptor surface expression was determined by specific monoclonal antibody recognition and flow cytometry, and signal transduction was detected by gel shift analysis.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 144)\n  (:start . 132) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 179)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s292.4) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002636@unknown@formal@none@1@S@HIV-1 activation and expression was quantitated by reverse transcriptase assay.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "quantitate") (:form . "quantitated") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "transcriptase") (:form . "transcriptase")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s292.5) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002637@unknown@formal@none@1@S@RESULTS : In the OM-10.1 promyelocytic model of chronic infection, TNF-alpha-induced HIV-1 expression also resulted in a substantial increase in 75 kd TNF receptor (TR75) expression although 55 kD TNF receptor (TR55) levels were not dramatically altered.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "om-10.1") (:form . "OM-10.1") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tnf-alpha-induced") (:form . "TNF-alpha-induced")\n  (:end . 84) (:start . 67) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 132)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kd") (:form . "kd") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TR75") (:form . "TR75") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 190)\n  (:start . 182) (:id . 71))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 196) (:start . 194)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "TR55") (:form . "TR55") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 223)\n  (:start . 217) (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 228) (:start . 224)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 232) (:start . 229)\n  (:id . 81))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 245)\n  (:start . 233) (:id . 82))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 253)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x292.6.1) (:span 229 232)))\n (:nscopes ((:id . :x292.6.1) (:span 191 253)))\n (:identifiers (:sid . :s292.6) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002638@unknown@formal@none@1@S@A series of uninfected parental HL-60 subclones all reduced TR75 surface expression in response to TNF-alpha treatment.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "tr75") (:form . "TR75") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s292.7) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002640@unknown@formal@none@1@S@An increase in TR75 expression was also evident during the peak of an acute HIV-1 infection of HL-60 promyelocytes.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TR75") (:form . "TR75") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 100)\n  (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "promyelocyte") (:form . "promyelocytes")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s292.9) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002641@unknown@formal@none@1@S@Although TR55 expression was unaltered during TNF-alpha-induced HIV activation, this receptor was still involved in the viral activation process.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TR55") (:form . "TR55") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "tnf-alpha-induced") (:form . "TNF-alpha-induced")\n  (:end . 63) (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 136)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s292.10) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002642@unknown@formal@none@1@S@Antibody cross-linking of TR55, in the absence of exogenous TNF-alpha, induced maximal HIV-1 expression, an up-modulation of surface TR75, and nuclear NF-kappa B activity in OM-10.1 cultures.@(((:tag . "NN") (:stem . "antibody") (:form . "Antibody") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TR55") (:form . "TR55") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "up-modulation") (:form . "up-modulation")\n  (:end . 121) (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "tr75") (:form . "TR75") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "om-10.1") (:form . "OM-10.1") (:end . 181)\n  (:start . 174) (:id . 71))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s292.11) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002643@unknown@formal@none@1@S@Surprisingly, this was the case even when an antagonistic anti-TR55 antibody was used.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "antagonistic") (:form . "antagonistic") (:end . 57)\n  (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "anti-tr55") (:form . "anti-TR55") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s292.12) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002644@unknown@formal@none@1@S@Anti-TR55 antibody cross-linking in chronically infected U1 promonocytic cultures could only partially substitute for TNF-alpha-induced HIV-1 expression.@(((:tag . "JJ") (:stem . "anti-tr55") (:form . "Anti-TR55") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 32) (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 72)\n  (:start . 60) (:id . 49))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 81)\n  (:start . 73) (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 87) (:start . 82)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 92) (:start . 88)\n  (:id . 52))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 102)\n  (:start . 93) (:id . 53))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 113)\n  (:start . 103) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tnf-alpha-induced") (:form . "TNF-alpha-induced")\n  (:end . 135) (:start . 118) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 141)\n  (:start . 136) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x292.13.1) (:span 82 87)))\n (:hscopes ((:id . :x292.13.1) (:span 82 152)))\n (:identifiers (:sid . :s292.13) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002645@unknown@formal@none@1@S@CONCLUSIONS : Our results demonstrated that HIV-1 infection can selectively influence the surface expression of TNF receptors, potentially influencing its own expression and altering normal immunoregulatory signal transduction.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . "VBG") (:stem . "influence") (:form . "influencing") (:end . 150)\n  (:start . 139) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 154) (:start . 151)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 182)\n  (:start . 174) (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 189)\n  (:start . 183) (:id . 67))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 206) (:start . 190) (:id . 68))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 213)\n  (:start . 207) (:id . 69))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 226)\n  (:start . 214) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x292.14.1) (:span 127 138)))\n (:hscopes ((:id . :x292.14.1) (:span 127 226)))\n (:identifiers (:sid . :s292.14) (:did . :|93363253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002646@unknown@formal@none@1@S@FK506 and ciclosporin: molecular probes for studying intracellular signal transduction.@(((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ciclosporin") (:form . "ciclosporin") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 86)\n  (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s293.1) (:did . :|94025289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002647@unknown@formal@none@1@S@The immunosuppressants ciclosporin and FK506 block the Ca(2+)-dependent signal-transduction pathway emanating from the T-cell receptor, thereby inhibiting the activation of helper T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ciclosporin") (:form . "ciclosporin") (:end . 34)\n  (:start . 23) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 44) (:start . 39)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 71) (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "signal-transduction")\n  (:form . "signal-transduction") (:end . 91) (:start . 72) (:id . 50))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 99)\n  (:start . 92) (:id . 51))\n ((:tag . "VBG") (:stem . "emanate") (:form . "emanating") (:end . 109)\n  (:start . 100) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 125)\n  (:start . 119) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 134)\n  (:start . 126) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 57))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 143)\n  (:start . 136) (:id . 58))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 154)\n  (:start . 144) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 169)\n  (:start . 159) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 62))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 179)\n  (:start . 173) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 181) (:start . 180)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s293.2) (:did . :|94025289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002648@unknown@formal@none@1@S@Using these drugs as probes, chemists and biologists have uncovered several intracellular signalling molecules bridging the generation of second-messenger Ca2+ ions and the transcriptional activation of IL-2, among which are calmodulin, calcineurin and the nuclear factor of activated T cells (NF-AT).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "chemist") (:form . "chemists") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . 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5002650@unknown@formal@none@1@S@As described by Jun Liu, these drugs manifest their effects in an unprecedented fashion.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Liu") (:form . "Liu") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "manifest") (:form . "manifest") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 51)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unprecedented") (:form . "unprecedented")\n  (:end . 79) (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s293.5) (:did . :|94025289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002651@unknown@formal@none@1@S@They do not directly intercept intracellular signalling molecules.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VB") (:stem . "intercept") (:form . "intercept") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x293.6.1) (:span 8 11)))\n (:nscopes ((:id . :x293.6.1) (:span 8 65)))\n (:identifiers (:sid . :s293.6) (:did . :|94025289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002652@unknown@formal@none@1@S@Instead, they form tight complexes with two different classes of abundant cytosolic receptors called immunophilins upon entering the cell, and consequently inhibit their peptidyl prolyl cis-trans isomerase activities.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "VBD") (:stem . "call") (:form . "called") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "immunophilin") (:form . "immunophilins")\n  (:end . 114) (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "enter") (:form . "entering") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "RB") (:stem . "consequently") (:form . "consequently") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 163)\n  (:start . 156) (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 169)\n  (:start . 164) (:id . 66))\n ((:tag . "JJ") (:stem . "peptidyl") (:form . "peptidyl") (:end . 178)\n  (:start . 170) (:id . 67))\n ((:tag . "JJ") (:stem . "prolyl") (:form . "prolyl") (:end . 185)\n  (:start . 179) (:id . 68))\n ((:tag . "JJ") (:stem . "cis-trans") (:form . "cis-trans") (:end . 195)\n  (:start . 186) (:id . 69))\n ((:tag . "NN") (:stem . "isomerase") (:form . "isomerase") (:end . 205)\n  (:start . 196) (:id . 70))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 216)\n  (:start . 206) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s293.7) (:did . :|94025289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002653@unknown@formal@none@1@S@The two structurally distinct immunophilin-drug complexes bind to, and inhibit, the phosphatase activity of calcineurin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "immunophilin-drug") (:form . "immunophilin-drug")\n  (:end . 47) (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 57)\n  (:start . 48) (:id . 47))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 62) (:start . 58)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s293.8) (:did . :|94025289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002654@unknown@formal@none@1@S@The impaired transcription factor AP-1 DNA binding activity in lymphocytes derived from subjects with some symptoms of premature aging.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "premature") (:form . "premature") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s294.1) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002655@unknown@formal@none@1@S@The study of human disorders known as premature aging syndromes may provide insight into the mechanisms of cellular senescence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "premature") (:form . "premature") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x294.2.1) (:span 64 67)))\n (:hscopes ((:id . :x294.2.1) (:span 64 126)))\n (:identifiers (:sid . :s294.2) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002656@unknown@formal@none@1@S@The main feature of cellular senescence in vitro is cessation of cell proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cessation") (:form . "cessation") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s294.3) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002657@unknown@formal@none@1@S@Down syndrome (DS) and neuronal ceroid-lypofuscinosis (NCL) are clinically characterized by the premature onset of numerous features normally associated with human aging.@(((:tag . "NN") (:stem . "down") (:form . "Down") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DS") (:form . "DS") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "neuronal") (:form . "neuronal") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "ceroid-lypofuscinosis")\n  (:form . "ceroid-lypofuscinosis") (:end . 53) (:start . 32) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NCL") (:form . "NCL") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "premature") (:form . "premature") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s294.4) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002658@unknown@formal@none@1@S@Phytohemagglutinin stimulated lymphocytes derived from DS subjects showed a statistically significant diminished proliferation capacity in comparison with lymphocytes derived from NCL and healthy individuals.@(((:tag . "NNP") (:stem . "Phytohemagglutinin") (:form . "Phytohemagglutinin")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "stimulated") (:form . "stimulated") (:end . 29)\n  (:start . 19) (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 41)\n  (:start . 30) (:id . 44))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 49)\n  (:start . 42) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DS") (:form . "DS") (:end . 57) (:start . 55)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 66)\n  (:start . 58) (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 73) (:start . 67)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 50))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 101)\n  (:start . 90) (:id . 52))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 112)\n  (:start . 102) (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 126) (:start . 113) (:id . 54))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 135)\n  (:start . 127) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 56))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 149)\n  (:start . 139) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 166)\n  (:start . 155) (:id . 59))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 174)\n  (:start . 167) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 179) (:start . 175)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NCL") (:form . "NCL") (:end . 183) (:start . 180)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 195)\n  (:start . 188) (:id . 64))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 207)\n  (:start . 196) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s294.5) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002660@unknown@formal@none@1@S@Our results showed that the same molecular mechanisms of proliferation cessation could exist in fibroblasts characterized by replicative senescence and in lymphocytes derived from individuals with premature aging syndromes (Down).@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "cessation") (:form . "cessation") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 121) (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 136)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 147)\n  (:start . 137) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 166)\n  (:start . 155) (:id . 63))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 174)\n  (:start . 167) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 179) (:start . 175)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 191)\n  (:start . 180) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 196) (:start . 192)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "premature") (:form . "premature") (:end . 206)\n  (:start . 197) (:id . 68))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 212)\n  (:start . 207) (:id . 69))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 222)\n  (:start . 213) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 224) (:start . 223)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Down") (:form . "Down") (:end . 228) (:start . 224)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 229) (:start . 228)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x294.7.1) (:span 81 86)))\n (:hscopes ((:id . :x294.7.1) (:span 81 229)))\n (:identifiers (:sid . :s294.7) (:did . :|94026053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002661@unknown@formal@none@1@S@Inhibition of HIV-1 latency reactivation by dehydroepiandrosterone (DHEA) and an analog of DHEA.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dehydroepiandrosterone")\n  (:form . "dehydroepiandrosterone") (:end . 66) (:start . 44) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DHEA") (:form . "DHEA") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "analog") (:form . "analog") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DHEA") (:form . "DHEA") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s295.1) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002662@unknown@formal@none@1@S@The initial infection with human immunodeficiency virus type 1 (HIV-1) in most individuals usually results in the establishment of a latent or chronic infection before eventual progression toward acquired immunodeficiency syndrome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 49) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "establishment") (:form . "establishment")\n  (:end . 127) (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . "JJ") (:stem . "eventual") (:form . "eventual") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 188)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 195)\n  (:start . 189) (:id . 71))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 221) (:start . 205) (:id . 73))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 230)\n  (:start . 222) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s295.2) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002663@unknown@formal@none@1@S@HIV-1 can also establish a latent or persistent infection in some T cell lines that show minimal constitutive virus expression.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "establish") (:form . "establish") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s295.3) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002664@unknown@formal@none@1@S@However, activation of the T cell lines leading to enhanced HIV-1 replication can be induced by antigens, mitogens, and cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin 1, and interleukin-2).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 129)\n  (:start . 120) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 145)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 158)\n  (:start . 153) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 169)\n  (:start . 160) (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 183)\n  (:start . 172) (:id . 74))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 77))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 204) (:start . 191) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 205) (:start . 204)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x295.4.1) (:span 78 81)))\n (:hscopes ((:id . :x295.4.1) (:span 9 205)))\n (:identifiers (:sid . :s295.4) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002665@unknown@formal@none@1@S@Various gene products from other viruses (HTLV-1, HSV, EBV, CMV, HBV, and HHV-6) can also enhance HIV-1 long terminal repeat ( LTR ) -driven reporter gene activity.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HSV") (:form . "HSV") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HBV") (:form . "HBV") (:end . 68) (:start . 65)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 79) (:start . 74)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 84) (:start . 81)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 89) (:start . 85)\n  (:id . 63))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 97)\n  (:start . 90) (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 103)\n  (:start . 98) (:id . 65))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 108) (:start . 104)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 117)\n  (:start . 109) (:id . 67))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 124)\n  (:start . 118) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 130) (:start . 127)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "-driven") (:form . "-driven") (:end . 140)\n  (:start . 133) (:id . 72))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 149)\n  (:start . 141) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 163)\n  (:start . 155) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s295.5) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002666@unknown@formal@none@1@S@On the basis of these observations, it has been proposed that reactivation of latent HIV-1 harbored in chronically infected T lymphocytes, monocytes, or macrophages plays an important role in the pathogenesis of AIDS.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 74)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "harbor") (:form . "harbored") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 164)\n  (:start . 153) (:id . 68))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 170)\n  (:start . 165) (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 183)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 74))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 208)\n  (:start . 196) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 216) (:start . 212)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x295.6.1) (:span 48 56)))\n (:hscopes ((:id . :x295.6.1) (:span 48 216)))\n (:identifiers (:sid . :s295.6) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002667@unknown@formal@none@1@S@So far, there are no drugs or therapy available that can provide protection against HIV-1 latency reactivation.@(((:tag . "RB") (:stem . "so") (:form . "So") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 13) (:start . 8)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 26) (:start . 21)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 37)\n  (:start . 30) (:id . 50))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 110)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x295.7.1) (:span 18 20)))\n (:nscopes ((:id . :x295.7.1) (:span 18 110)))\n (:identifiers (:sid . :s295.7) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002668@unknown@formal@none@1@S@ACH-2, derived from a human T cell line (CEM), is chronically infected with HIV-1, with low levels of constitutive virus expression.@(((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 55))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 61)\n  (:start . 50) (:id . 56))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 70)\n  (:start . 62) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 81) (:start . 76)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 91) (:start . 88)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 98)\n  (:start . 92) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 114)\n  (:start . 102) (:id . 65))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 120)\n  (:start . 115) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s295.8) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002670@unknown@formal@none@1@S@Therefore the ACH-2 cell line is a good candidate for studying the effects of drugs on HIV-1 activation.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s295.10) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002671@unknown@formal@none@1@S@Previously, we have reported that DHEA and synthetic analogs of DHEA can be modest inhibitors of HIV-1 IIIB replication in phytohemagglutinin-stimulated peripheral blood lymphocyte cultures.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DHEA") (:form . "DHEA") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DHEA") (:form . "DHEA") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "modest") (:form . "modest") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 102)\n  (:start . 97) (:id . 59))\n ((:tag . "NNP") (:stem . "IIIB") (:form . "IIIB") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 119)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "phytohemagglutinin-stimulated")\n  (:form . "phytohemagglutinin-stimulated") (:end . 152) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 163)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 169)\n  (:start . 164) (:id . 65))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 180)\n  (:start . 170) (:id . 66))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 189)\n  (:start . 181) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s295.11) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002672@unknown@formal@none@1@S@(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "abstract") (:form . "ABSTRACT") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s295.12) (:did . :|94031267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002673@unknown@formal@none@1@S@Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "septic") (:form . "septic") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s296.1) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002674@unknown@formal@none@1@S@Cells of monocyte lineage serve as effector cells in the cellular immune response.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s296.2) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002675@unknown@formal@none@1@S@In addition, they respond to LPS and cytokines with activation and expression of inflammatory effector gene products similar to those elicited by the antigen driven response.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "driven") (:form . "driven") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s296.3) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002676@unknown@formal@none@1@S@The response to antigen proceeds at the T helper cell level through two independent forms of cellular collaboration, contact and lymphokine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "proceed") (:form . "proceeds") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "collaboration") (:form . "collaboration")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s296.4) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002677@unknown@formal@none@1@S@We review the control of expression of the Tissue Factor (TF) gene and the function of the TF protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "review") (:form . "review") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "Factor") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 83)\n  (:start . 75) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 93) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s296.5) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002678@unknown@formal@none@1@S@The enhanced initiation of transcription of the TF gene appears to require engagement of a 56 bp LPS Response Element, an enhancer that is engaged by both AP-1 type heterodimeric complexes as well as NF kappa B like heterodimeric complexes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "CD") (:stem . "56") (:form . "56") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Response") (:form . "Response") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NNP") (:stem . "Element") (:form . "Element") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "engage") (:form . "engaged") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 159) (:start . 155)\n  (:id . 70))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 164) (:start . 160)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 178) (:start . 165) (:id . 72))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 188)\n  (:start . 179) (:id . 73))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 202) (:start . 200)\n  (:id . 77))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 215) (:start . 211)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 229) (:start . 216) (:id . 81))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 239)\n  (:start . 230) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x296.6.1) (:span 56 63)))\n (:hscopes ((:id . :x296.6.1) (:span 0 239)))\n (:identifiers (:sid . :s296.6) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002680@unknown@formal@none@1@S@Enhancement of expression of TF is observed upon adhesion of Mo to endothelial cells and extracellular matrix proteins, as well as upon engagement of leukocyte integrins.@(((:tag . "NN") (:stem . "enhancement") (:form . "Enhancement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Mo") (:form . "Mo") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 78)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 169)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s296.8) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002681@unknown@formal@none@1@S@The biological effects that follow from expression of TF by vascular cells have been resolved by analysis of function aided by the use of recombinant full length TF and truncated surface domain of TF.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "resolve") (:form . "resolved") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "VBN") (:stem . "aid") (:form . "aided") (:end . 123) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 149)\n  (:start . 138) (:id . 66))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 178)\n  (:start . 169) (:id . 71))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 186)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 199) (:start . 197)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s296.9) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002682@unknown@formal@none@1@S@The rules of assembly of the cognate ligands of TF, namely the zymogen plasma factors VII and the serine protease factor VIIa, with the soluble surface domain of TF in free solution, in the presence of phospholipid surfaces and cell surface and of the anchored TF molecule have been described.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "rule") (:form . "rules") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . 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5002683@unknown@formal@none@1@S@It is evident that assembly of the surface domain of TF with VIIa to form the binary TF.VIIa complex induces a significant increase in the Kcat of the catalytic domain of VIIa for small peptidyl substrates and more profoundly for protein substrate.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VIIa") (:form . "VIIa") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 84)\n  (:start . 78) (:id . 58))\n ((:tag . "NNP") (:stem . "TF.VIIa") (:form . "TF.VIIa") (:end . 92)\n  (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 100)\n  (:start . 93) (:id . 60))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 122)\n  (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kcat") (:form . "Kcat") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 160)\n  (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 167)\n  (:start . 161) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "VIIa") (:form . "VIIa") (:end . 175) (:start . 171)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 185)\n  (:start . 180) (:id . 75))\n ((:tag . "JJ") (:stem . "peptidyl") (:form . "peptidyl") (:end . 194)\n  (:start . 186) (:id . 76))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 205)\n  (:start . 195) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 214) (:start . 210)\n  (:id . 79))\n ((:tag . "RB") (:stem . "profoundly") (:form . "profoundly") (:end . 225)\n  (:start . 215) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 229) (:start . 226)\n  (:id . 81))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 237)\n  (:start . 230) (:id . 82))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 247)\n  (:start . 238) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s296.11) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002684@unknown@formal@none@1@S@This provides substantial evidence for an allosteric effect on the catalytic cleft of VIIa that is imparted by binding to TF, its cognate catalytic cofactor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "allosteric") (:form . "allosteric") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "cleft") (:form . "cleft") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "VIIa") (:form . "VIIa") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "impart") (:form . "imparted") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 147)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s296.12) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002685@unknown@formal@none@1@S@It is also evident that the TF.VIIa complex is proteolytically active and can activate the zymogen plasma factor X to the serine protease Xa in free solution, inferring that extended substrate recognition by induced structural loci of the TF.VIIa complex are created from either or both proteins to constitute a new recognition structure.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TF.VIIa") (:form . 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"both") (:end . 286) (:start . 282)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 295)\n  (:start . 287) (:id . 89))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 298) (:start . 296)\n  (:id . 90))\n ((:tag . "VB") (:stem . "constitute") (:form . "constitute") (:end . 309)\n  (:start . 299) (:id . 91))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 311) (:start . 310)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 315) (:start . 312)\n  (:id . 93))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 327)\n  (:start . 316) (:id . 94))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 337)\n  (:start . 328) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 338) (:start . 337)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s296.13) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002686@unknown@formal@none@1@S@It is also evident that association of X with charged phospholipid surfaces enhances the proteolytic activation of this zymogen by increasing recognition and susceptibility of the sessile peptide bond deduced from the markedly decreased Km and increased Kcat.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "charged") (:form . "charged") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "JJ") (:stem . "phospholipid") (:form . "phospholipid") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "zymogen") (:form . "zymogen") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 153)\n  (:start . 142) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 172) (:start . 158) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sessile") (:form . "sessile") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 195)\n  (:start . 188) (:id . 69))\n ((:tag . "NN") (:stem . "bond") (:form . "bond") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "deduce") (:form . "deduced") (:end . 208)\n  (:start . 201) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 213) (:start . 209)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 226)\n  (:start . 218) (:id . 74))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 236)\n  (:start . 227) (:id . 75))\n ((:tag . "NNP") (:stem . "Km") (:form . "Km") (:end . 239) (:start . 237)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 253)\n  (:start . 244) (:id . 78))\n ((:tag . "NNP") (:stem . "Kcat") (:form . "Kcat") (:end . 258) (:start . 254)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s296.14) (:did . :|94051535|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002687@unknown@formal@none@1@S@Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers.@(((:tag . "NNP") (:stem . "Visualization") (:form . "Visualization")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "follicular") (:form . "follicular") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "center") (:form . "centers") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s297.1) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002688@unknown@formal@none@1@S@NF-kappa B, a 50 kDa/65 kDa (p50/p65) heterodimer, is a ubiquitous transcription factor involved in the positive regulation of various immune genes.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kda/65") (:form . "kDa/65") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 36)\n  (:start . 29) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 49)\n  (:start . 38) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 66)\n  (:start . 56) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 87)\n  (:start . 81) (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 112)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s297.2) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002690@unknown@formal@none@1@S@Using in situ hybridization on sections from non HIV hyperplastic lymph nodes, we found that the gene of the 105 kDa precursor of p50 was overexpressed in the light zone of germinal centers, with a network aspect, which suggested the involvement of follicular dendritic cells (FDC).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . 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"cells") (:end . 275)\n  (:start . 270) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 277) (:start . 276)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 280) (:start . 277)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 281) (:start . 280)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x297.4.1) (:span 220 229)))\n (:hscopes ((:id . :x297.4.1) (:span 220 281)))\n (:identifiers (:sid . :s297.4) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002691@unknown@formal@none@1@S@By immunohistochemistry, p50 protein was detected in the cytoplasm and nucleus of FDC, confirming the involvement of FDC.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 23) (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "confirm") (:form . "confirming") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s297.5) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002692@unknown@formal@none@1@S@Furthermore, p50 protein was detected in the cytoplasm of all lymphocytes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s297.6) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002693@unknown@formal@none@1@S@Thus, we focused our study on isolated FDC clusters from normal tonsils.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "focus") (:form . "focused") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 38)\n  (:start . 30) (:id . 49))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "tonsil") (:form . "tonsils") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s297.7) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002694@unknown@formal@none@1@S@As showed on tissue sections, we detected the p50 in both cytoplasm and nucleus of FDC.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "showed") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s297.8) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002695@unknown@formal@none@1@S@Nuclei of lymphocytes from FDC clusters were negative.@(((:tag . "NNP") (:stem . "Nucleus") (:form . "Nuclei") (:end . 6)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s297.9) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002696@unknown@formal@none@1@S@We next studied p65 and c-Rel protein expression in FDC clusters.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s297.10) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002697@unknown@formal@none@1@S@p65 was detected in the cytoplasm of FDC, whereas nuclei were negative.@(((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s297.11) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002698@unknown@formal@none@1@S@Furthermore, p65 was detected in the nuclei of some lymphocytes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s297.12) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002700@unknown@formal@none@1@S@Our results indicated that , in the context of T cell-dependent B cell immunopoiesis occurring in FDC clusters, p50 is mainly related to FDC with a massive overexpression in the nuclei, whereas p65 is expressed in a scattered manner in the nuclei of lymphocytes and c-Rel protein exclusively in the cytoplasm of lymphocytes from FDC clusters.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-dependent") (:form . "cell-dependent")\n  (:end . 63) (:start . 49) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunopoiesis") (:form . "immunopoiesis")\n  (:end . 84) (:start . 71) (:id . 55))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "massive") (:form . "massive") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 170) (:start . 156) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 193)\n  (:start . 186) (:id . 75))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 197) (:start . 194)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 210)\n  (:start . 201) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 213) (:start . 211)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 215) (:start . 214)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "scattered") (:form . "scattered") (:end . 225)\n  (:start . 216) (:id . 81))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 232)\n  (:start . 226) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 246)\n  (:start . 240) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 249) (:start . 247)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 261)\n  (:start . 250) (:id . 87))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 265) (:start . 262)\n  (:id . 88))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 271)\n  (:start . 266) (:id . 89))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 279)\n  (:start . 272) (:id . 90))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 291)\n  (:start . 280) (:id . 91))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 294) (:start . 292)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 298) (:start . 295)\n  (:id . 93))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 308)\n  (:start . 299) (:id . 94))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 311) (:start . 309)\n  (:id . 95))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 323)\n  (:start . 312) (:id . 96))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 328) (:start . 324)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 332) (:start . 329)\n  (:id . 98))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 341)\n  (:start . 333) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 342) (:start . 341)\n  (:id . 100)))@@@1@59@((:hcues ((:id . :x297.14.1) (:span 12 26)))\n (:hscopes ((:id . :x297.14.1) (:span 12 341)))\n (:identifiers (:sid . :s297.14) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002701@unknown@formal@none@1@S@These results suggested that the two subunits of NF-kappa B and the c-Rel protein have different roles in different cell types during B cell immunopoiesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "immunopoiesis") (:form . "immunopoiesis")\n  (:end . 154) (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x297.15.1) (:span 14 23)))\n (:hscopes ((:id . :x297.15.1) (:span 14 154)))\n (:identifiers (:sid . :s297.15) (:did . :|94075814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002702@unknown@formal@none@1@S@Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "yb-1") (:form . "YB-1") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s298.1) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002703@unknown@formal@none@1@S@Sequences which control basal human T-cell lymphotropic virus type I (HTLV-I) transcription likely play an important role in initiation and maintenance of virus replication.@(((:tag . "NNP") (:stem . "Sequence") (:form . "Sequences") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 55))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 172)\n  (:start . 161) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x298.2.1) (:span 92 98)))\n (:hscopes ((:id . :x298.2.1) (:span 92 172)))\n (:identifiers (:sid . :s298.2) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002704@unknown@formal@none@1@S@We previously identified and analyzed a 45-nucleotide sequence (downstream regulatory element 1 [DRE 1]), +195 to +240, at the boundary of the R/U5 region of the long terminal repeat which is required for HTLV-I basal transcription.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "45-nucleotide") (:form . "45-nucleotide")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DRE") (:form . "DRE") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "CD") (:stem . "+195") (:form . "+195") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "+240") (:form . "+240") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 135)\n  (:start . 127) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 69))\n ((:tag . "NN") (:stem . "r/u5") (:form . "R/U5") (:end . 147) (:start . 143)\n  (:id . 70))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 154)\n  (:start . 148) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 166) (:start . 162)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 175)\n  (:start . 167) (:id . 75))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 182)\n  (:start . 176) (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 188)\n  (:start . 183) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 191) (:start . 189)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 200)\n  (:start . 192) (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 211)\n  (:start . 205) (:id . 81))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 217)\n  (:start . 212) (:id . 82))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 231) (:start . 218) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s298.3) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002705@unknown@formal@none@1@S@We identified a protein, p37, which specifically bound to DRE 1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p37") (:form . "p37") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 48)\n  (:start . 36) (:id . 50))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dre") (:form . "DRE") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s298.4) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002706@unknown@formal@none@1@S@An affinity column fraction, containing p37, stimulated HTLV-I transcription approximately 12-fold in vitro.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "p37") (:form . "p37") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . "RB") (:stem . "12-fold") (:form . "12-fold") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s298.5) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002707@unknown@formal@none@1@S@We now report the identification of a cDNA clone (15B-7), from a Jurkat expression library, that binds specifically to the DRE 1 regulatory sequence.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "15b-7") (:form . "15B-7") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 71)\n  (:start . 65) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 58))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 102) (:start . 97)\n  (:id . 62))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 115)\n  (:start . 103) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DRE") (:form . "DRE") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 139)\n  (:start . 129) (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 148)\n  (:start . 140) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s298.6) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002708@unknown@formal@none@1@S@Binding of the cDNA fusion protein, similarly to the results obtained with purified Jurkat protein, was decreased by introduction of site-specific mutations in the DRE 1 regulatory sequence.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "introduction") (:form . "introduction") (:end . 129)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "site-specific") (:form . "site-specific")\n  (:end . 146) (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 156)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DRE") (:form . "DRE") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 180)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s298.7) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002710@unknown@formal@none@1@S@The partial cDNA encodes a protein which is homologous to the C-terminal 196 amino acids of the 36-kDa transcription factor, YB-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "CD") (:stem . "196") (:form . "196") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "36-kda") (:form . "36-kDa") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "YB-1") (:form . "YB-1") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s298.9) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002711@unknown@formal@none@1@S@Cotransfection of a YB-1 expression plasmid increases HTLV-I basal transcription approximately 14-fold in Jurkat T lymphocytes.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "yb-1") (:form . "YB-1") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 51))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 94) (:start . 81) (:id . 52))\n ((:tag . "RB") (:stem . "14-fold") (:form . "14-fold") (:end . 102)\n  (:start . 95) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 112)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 126)\n  (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s298.10) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002712@unknown@formal@none@1@S@On the basis of the molecular weight, DNA-binding characteristics, and in vivo transactivation activity, we suggest that the previously identified DRE 1-binding protein, p37, is YB-1.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 65) (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 94) (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "dre") (:form . "DRE") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "1-binding") (:form . "1-binding") (:end . 160)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 168)\n  (:start . 161) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p37") (:form . "p37") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "NN") (:stem . "yb-1") (:form . "YB-1") (:end . 182) (:start . 178)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x298.11.1) (:span 108 115)))\n (:hscopes ((:id . :x298.11.1) (:span 108 182)))\n (:identifiers (:sid . :s298.11) (:did . :|94076456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002713@unknown@formal@none@1@S@Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system.@(((:tag . "VBN") (:stem . "chlorinate") (:form . "Chlorinated") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "dibenzo-p-dioxin") (:form . "dibenzo-p-dioxins")\n  (:end . 29) (:start . 12) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "dibenzofuran") (:form . "dibenzofurans")\n  (:end . 47) (:start . 34) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 75)\n  (:start . 69) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s299.1) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002714@unknown@formal@none@1@S@1 . Blood cell receptors in volunteers with moderately increased body burdens.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "Blood") (:form . "Blood") (:end . 9) (:start . 4)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "moderately") (:form . "moderately") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "burden") (:form . "burdens") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s299.2) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002715@unknown@formal@none@1@S@Using monoclonal antibodies (mAbs) and flow cytometry, we studied a variety of surface receptors on lymphocyte subpopulations of workers with moderately increased body burdens of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and of other polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDF), expressed here as International-Toxicity Equivalencies (I-TE).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . 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"IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "2,3,7,8-tetrachlorodibenzo-p-dioxin")\n  (:form . "2,3,7,8-tetrachlorodibenzo-p-dioxin") (:end . 214) (:start . 179)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 216) (:start . 215)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 220) (:start . 216)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 221) (:start . 220)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 234)\n  (:start . 229) (:id . 76))\n ((:tag . "VBN") (:stem . "polychlorinate") (:form . "polychlorinated")\n  (:end . 250) (:start . 235) (:id . 77))\n ((:tag . "NNS") (:stem . "dibenzo-p-dioxin") (:form . 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"International-Toxicity") (:end . 340) (:start . 318) (:id . 88))\n ((:tag . "NNPS") (:stem . "Equivalency") (:form . "Equivalencies")\n  (:end . 354) (:start . 341) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 356) (:start . 355)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "I-TE") (:form . "I-TE") (:end . 360) (:start . 356)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 361) (:start . 360)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 362) (:start . 361)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s299.3) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002716@unknown@formal@none@1@S@The hypothesis to be tested was whether or not humans exhibit a similar susceptibility to PCDDs/PCDFs with respect to the surface receptors found previously to respond to small doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Callithrix jacchus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 27) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 86) (:start . 72) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "pcdds/pcdf") (:form . "PCDDs/PCDFs") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "2,3,7,8-tetrachlorodibenzo-p-dioxin")\n  (:form . "2,3,7,8-tetrachlorodibenzo-p-dioxin") (:end . 221) (:start . 186)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 223) (:start . 222)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 231) (:start . 229)\n  (:id . 76))\n ((:tag . "FW") (:stem . "callithrix") (:form . "Callithrix") (:end . 242)\n  (:start . 232) (:id . 77))\n ((:tag . "FW") (:stem . "jacchus") (:form . "jacchus") (:end . 250)\n  (:start . 243) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x299.4.1) (:span 32 46)))\n (:hscopes ((:id . :x299.4.1) (:span 32 250)))\n (:identifiers (:sid . :s299.4) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002717@unknown@formal@none@1@S@These are : helper-inducer (memory) T cells (CD4+CD45R0+CD45RA-CD29highCD11a+), CD20+ B cells, and cytotoxic T cells (CD8+CD56+/CD57+).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "helper-inducer") (:form . "helper-inducer")\n  (:end . 26) (:start . 12) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd4+cd45r0+cd45ra-cd29highcd11a+")\n  (:form . "CD4+CD45R0+CD45RA-CD29highCD11a+") (:end . 77) (:start . 45)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd20+") (:form . "CD20+") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cd8+cd56+/cd57+") (:form . "CD8+CD56+/CD57+")\n  (:end . 133) (:start . 118) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s299.5) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002718@unknown@formal@none@1@S@Furthermore, 68 triple-labellings with mAbs were performed on the cells of each volunteer to possibly generate further hypotheses.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "68") (:form . "68") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "triple-labelling") (:form . "triple-labellings")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "volunteer") (:form . "volunteer") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "hypothesis") (:form . "hypotheses") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x299.6.1) (:span 93 101)))\n (:hscopes ((:id . :x299.6.1) (:span 93 129)))\n (:identifiers (:sid . :s299.6) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002720@unknown@formal@none@1@S@There were two main goals: ( 1 ) to evaluate whether workers with a moderately increased PCDD/PCDF-body burden [25-140 ppt TCDD or 104-522 ppt I-TE in blood fat] exhibit changes in the surface receptors of white blood cells, as observed in previous studies in non-human primates, and ( 2 ) to clarify whether persons at the upper range [10-23 ppt TCDD or 30-90 ppt I-TE in blood fat] of the body burden reference values of a not particularly exposed population show detectable deviations in these immunological variables, when compared with persons at the lower and medium range [1-3 ppt TCDD or 9-29 ppt I-TE] of these body burden reference values.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "main") (:form . 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5002721@unknown@formal@none@1@S@Regression analysis of our data revealed slight trends for some of the biomarkers (e.g.@(((:tag . "NNP") (:stem . "Regression") (:form . "Regression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "trend") (:form . "trends") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "biomarker") (:form . "biomarkers") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "e.g") (:form . "e.g") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s299.9) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002722@unknown@formal@none@1@S@CD45R0+).@(((:tag . "JJ") (:stem . "cd45r0+") (:form . "CD45R0+") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 9) (:start . 8) (:id . 44)))@@@1@3@((:identifiers (:sid . :s299.10) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002723@unknown@formal@none@1@S@With one exception, these were all increases.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s299.11) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002724@unknown@formal@none@1@S@None of the alterations observed are of medical relevance.@(((:tag . "NN") (:stem . "none") (:form . "None") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "medical") (:form . "medical") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s299.12) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002725@unknown@formal@none@1@S@The slight increase in the percentage of CD4+CD45R0+ cells remained significant even after covariant analysis taking age-related changes into account.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd4+cd45r0+") (:form . "CD4+CD45R0+") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "covariant") (:form . "covariant") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 128)\n  (:start . 117) (:id . 58))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 136)\n  (:start . 129) (:id . 59))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "account") (:form . "account") (:end . 149)\n  (:start . 142) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s299.13) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002726@unknown@formal@none@1@S@Altogether, the data do not provide any evidence to support an assumption that moderately increased body burdens of PCDDs/PCDFs in adults induce decreases in the cellular components of the human immune system.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "moderately") (:form . "moderately") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "burden") (:form . "burdens") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "pcdds/pcdf") (:form . "PCDDs/PCDFs") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 144)\n  (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 181)\n  (:start . 171) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 194)\n  (:start . 189) (:id . 72))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 208)\n  (:start . 202) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x299.14.1) (:span 63 73)))\n (:ncues ((:id . :x299.14.2) (:span 24 27)))\n (:hscopes ((:id . :x299.14.1) (:span 63 208)))\n (:nscopes ((:id . :x299.14.2) (:span 24 208)))\n (:identifiers (:sid . :s299.14) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002727@unknown@formal@none@1@S@Adult humans certainly are less susceptible to this action of PCDDs/PCDFs than adolescent Callithrix jacchus.@(((:tag . "JJ") (:stem . "adult") (:form . "Adult") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "certainly") (:form . "certainly") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pcdds/pcdf") (:form . "PCDDs/PCDFs") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "adolescent") (:form . "adolescent") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "NNP") (:stem . "Callithrix") (:form . "Callithrix") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "jacchus") (:form . "jacchus") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s299.15) (:did . :|94077003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002728@unknown@formal@none@1@S@The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lymphotoxin") (:form . "lymphotoxin") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s300.1) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002730@unknown@formal@none@1@S@Tax-expressing cell lines produce LT biologic activity.@(((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 19) (:start . 15)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "lt") (:form . "LT") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s300.3) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002731@unknown@formal@none@1@S@An LT promoter (LT-293) CAT construct that contained an NF-kappa B site was active in the LT-producing C81-66-45 cell line, which contains defective HTLV-I but expresses tax.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LT") (:form . "LT") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LT-293") (:form . "LT-293") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 37)\n  (:start . 28) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lt-producing") (:form . "LT-producing") (:end . 102)\n  (:start . 90) (:id . 60))\n ((:tag . "NNP") (:stem . "C81-66-45") (:form . "C81-66-45") (:end . 112)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 169)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s300.4) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002732@unknown@formal@none@1@S@The observation that a mutated LT-kappa B construct (M1-CAT) was inactive in C81-66-45, confirmed the importance of NF-kappa B in LT gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "LT-kappa") (:form . "LT-kappa") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M1-CAT") (:form . "M1-CAT") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C81-66-45") (:form . "C81-66-45") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LT") (:form . "LT") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s300.5) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002733@unknown@formal@none@1@S@Tax was transfected into HTLV-I-negative human T-cell lines.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "htlv-i-negative") (:form . "HTLV-I-negative")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s300.6) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002734@unknown@formal@none@1@S@Jurkat T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa B site.@(((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LT-kappa") (:form . "LT-kappa") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s300.7) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002735@unknown@formal@none@1@S@Tax co-transfected with reporter constructs into Jurkat cells maximally activated HTLV-I-LTR-CAT and kappa B-fos-CAT and also activated LT-293 to a lesser extent.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "co-transfecte") (:form . "co-transfected")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "maximally") (:form . "maximally") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 81)\n  (:start . 72) (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-I-LTR-CAT") (:form . "HTLV-I-LTR-CAT")\n  (:end . 96) (:start . 82) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 106)\n  (:start . 101) (:id . 54))\n ((:tag . "NNP") (:stem . "B-fos-CAT") (:form . "B-fos-CAT") (:end . 116)\n  (:start . 107) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 125) (:start . 121)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "lt-293") (:form . "LT-293") (:end . 142)\n  (:start . 136) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 154)\n  (:start . 148) (:id . 62))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 161)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s300.8) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002736@unknown@formal@none@1@S@In JM T cells, tax induced LT-293 activity by two- to four-fold, though there was no induction of M1-CAT.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "JM") (:form . "JM") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 18) (:start . 15)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 26)\n  (:start . 19) (:id . 48))\n ((:tag . "NN") (:stem . "lt-293") (:form . "LT-293") (:end . 33)\n  (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 42)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "RB") (:stem . "four-fold") (:form . "four-fold") (:end . 63)\n  (:start . 54) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 71)\n  (:start . 65) (:id . 56))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "M1-CAT") (:form . "M1-CAT") (:end . 104)\n  (:start . 98) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x300.9.1) (:span 82 84)))\n (:nscopes ((:id . :x300.9.1) (:span 82 104)))\n (:identifiers (:sid . :s300.9) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002737@unknown@formal@none@1@S@The increase in LT-293 CAT activity mirrored the increase in LT biologic activity seen under these conditions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LT-293") (:form . "LT-293") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "mirror") (:form . "mirrored") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LT") (:form . "LT") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s300.10) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002738@unknown@formal@none@1@S@These studies, the first to demonstrate induction of LT promoter activity over basal levels, indicate that HTLV-I tax causes low-level activation of both endogenous LT and the LT promoter, at least in part through activation of NF-kappa B.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LT") (:form . "LT") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "JJ") (:stem . "low-level") (:form . "low-level") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 164)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "lt") (:form . "LT") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LT") (:form . "LT") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 187)\n  (:start . 179) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 197)\n  (:start . 192) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 76))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 205) (:start . 201)\n  (:id . 77))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 213)\n  (:start . 206) (:id . 78))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 224)\n  (:start . 214) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 236)\n  (:start . 228) (:id . 81))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 238) (:start . 237)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x300.11.1) (:span 93 106)))\n (:hscopes ((:id . :x300.11.1) (:span 93 238)))\n (:identifiers (:sid . :s300.11) (:did . :|94083530|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002740@unknown@formal@none@1@S@Results in two affected infants.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "infant") (:form . "infants") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 32) (:start . 31)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s301.2) (:did . :|94085904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002741@unknown@formal@none@1@S@We report two patients with transient pseudohypoaldosteronism due to obstructive renal disease.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "pseudohypoaldosteronism")\n  (:form . "pseudohypoaldosteronism") (:end . 61) (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "obstructive") (:form . "obstructive") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 94)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s301.3) (:did . :|94085904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002742@unknown@formal@none@1@S@Both patients presented with a salt-losing episode simulating adrenal insufficiency.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "present") (:form . "presented") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "salt-losing") (:form . "salt-losing") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "episode") (:form . "episode") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "VBG") (:stem . "simulate") (:form . "simulating") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "insufficiency") (:form . "insufficiency")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s301.4) (:did . :|94085904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002743@unknown@formal@none@1@S@In one patient, transient reduction of aldosterone receptors could be documented, while in the second patient the clinical and biochemical parameters were consistent with transient pseudohypoaldosteronism.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 138)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "pseudohypoaldosteronism")\n  (:form . "pseudohypoaldosteronism") (:end . 204) (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s301.5) (:did . :|94085904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002744@unknown@formal@none@1@S@Aldosterone receptors were normal in both patients when studied after the surgical correction of the obstruction.@(((:tag . "NNP") (:stem . "Aldosterone") (:form . "Aldosterone") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "surgical") (:form . "surgical") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "obstruction") (:form . "obstruction") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s301.6) (:did . :|94085904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002745@unknown@formal@none@1@S@The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 64) (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 93)\n  (:start . 83) (:id . 52))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 112) (:start . 94) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 128)\n  (:start . 120) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s302.1) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002746@unknown@formal@none@1@S@The macrophage colony-stimulating factor (M-CSF) receptor is expressed in a tissue-specific fashion from two distinct promoters in monocytes/macrophages and the placenta.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 33) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 91) (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 152) (:start . 131) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "placenta") (:form . "placenta") (:end . 169)\n  (:start . 161) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s302.2) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002747@unknown@formal@none@1@S@In order to further understand the transcription factors which play a role in the commitment of multipotential progenitors to the monocyte/macrophage lineage, we have initiated an investigation of the factors which activate the M-CSF receptor very early during the monocyte differentiation process.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "multipotential") (:form . "multipotential")\n  (:end . 110) (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 149) (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 157)\n  (:start . 150) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 176)\n  (:start . 167) (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 193) (:start . 180) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 208)\n  (:start . 201) (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 223)\n  (:start . 215) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 233)\n  (:start . 228) (:id . 76))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 242)\n  (:start . 234) (:id . 77))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 247) (:start . 243)\n  (:id . 78))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 253)\n  (:start . 248) (:id . 79))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 260)\n  (:start . 254) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 264) (:start . 261)\n  (:id . 81))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 273)\n  (:start . 265) (:id . 82))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 289) (:start . 274) (:id . 83))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 297)\n  (:start . 290) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 298) (:start . 297)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s302.3) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002748@unknown@formal@none@1@S@Here we demonstrate that the human monocytic M-CSF receptor promoter directs reporter gene activity in a tissue-specific fashion.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 120) (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s302.4) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002750@unknown@formal@none@1@S@Here we demonstrate that both in vitro-translated PU.1 and PU.1 from nuclear extracts bind to a specific site in the M-CSF receptor promoter just upstream from the major transcription initiation site.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "vitro-translated") (:form . "vitro-translated")\n  (:end . 49) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 183) (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s302.6) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002751@unknown@formal@none@1@S@Mutations in this site which eliminate PU.1 binding decrease M-CSF receptor promoter activity significantly in macrophage cell lines only.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "eliminate") (:form . "eliminate") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBP") (:stem . "decrease") (:form . "decrease") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 107) (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 121)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 132)\n  (:start . 127) (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s302.7) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002752@unknown@formal@none@1@S@Furthermore, PU.1 transactivates the M-CSF receptor promoter in nonmacrophage cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "transactivate") (:form . "transactivates")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nonmacrophage") (:form . "nonmacrophage")\n  (:end . 77) (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s302.8) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002753@unknown@formal@none@1@S@These results suggest that PU.1 plays a major role in macrophage gene regulation and development by directing the expression of a receptor for a key macrophage growth factor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 159)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 173)\n  (:start . 167) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x302.9.1) (:span 14 21)))\n (:hscopes ((:id . :x302.9.1) (:span 14 173)))\n (:identifiers (:sid . :s302.9) (:did . :|94088534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002754@unknown@formal@none@1@S@Increased natural killer cell activity correlates with low or negative expression of the HER-2/neu oncogene in patients with breast cancer.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x303.1.1) (:span 59 61)))\n (:hscopes ((:id . :x303.1.1) (:span 55 70)))\n (:identifiers (:sid . :s303.1) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002755@unknown@formal@none@1@S@BACKGROUND .@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 12) (:start . 11)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s303.2) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002756@unknown@formal@none@1@S@Increased expression of the HER-2/neu oncogene in breast cancer correlates with decreased estrogen receptor concentration and seems to be an important prognostic factor.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 121) (:start . 108) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 131)\n  (:start . 126) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 150)\n  (:start . 141) (:id . 62))\n ((:tag . "JJ") (:stem . "prognostic") (:form . "prognostic") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 168)\n  (:start . 162) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x303.3.1) (:span 126 131)))\n (:hscopes ((:id . :x303.3.1) (:span 126 168)))\n (:identifiers (:sid . :s303.3) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002757@unknown@formal@none@1@S@The authors investigated whether there is a correlation between HER-2/neu expression and immunologic parameters representing tumor defense in patients with breast cancer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 124)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 130)\n  (:start . 125) (:id . 57))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 138)\n  (:start . 131) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 150)\n  (:start . 142) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 61))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 162)\n  (:start . 156) (:id . 62))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 169)\n  (:start . 163) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x303.4.1) (:span 25 32)))\n (:hscopes ((:id . :x303.4.1) (:span 25 169)))\n (:identifiers (:sid . :s303.4) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002758@unknown@formal@none@1@S@METHOD .@(((:tag . "NN") (:stem . "method") (:form . "METHOD") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 8) (:start . 7) (:id . 43)))@@@1@2@((:identifiers (:sid . :s303.5) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002760@unknown@formal@none@1@S@RESULTS .@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 9) (:start . 8) (:id . 43)))@@@1@2@((:identifiers (:sid . :s303.7) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002761@unknown@formal@none@1@S@In patients with breast cancer, NK cell activity was significantly higher compared with patients with benign tumors (P = 0.006) or healthy control subjects (P = 0.002).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 73) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "benign") (:form . "benign") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.006") (:form . "0.006") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 138)\n  (:start . 131) (:id . 66))\n ((:tag . "JJ") (:stem . "control") (:form . "control") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . "CD") (:stem . "0.002") (:form . "0.002") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s303.8) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002762@unknown@formal@none@1@S@Moreover, 23.3 % of patients with breast cancer showed an overexpression of HER-2/neu protein.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "CD") (:stem . "23.3") (:form . "23.3") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 54) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 72) (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s303.9) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002763@unknown@formal@none@1@S@Within this group of patients, NK cell activity was significantly lower (45.6 ± 16.1%) compared with the group with no HER-2/neu overexpression (57.3 ± 11.0%).@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 65) (:start . 52) (:id . 52))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "CD") (:stem . "45.6") (:form . "45.6") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "SYM") (:stem . "±") (:form . "±") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "CD") (:stem . "16.1") (:form . "16.1") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 110)\n  (:start . 105) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 128)\n  (:start . 119) (:id . 66))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 143) (:start . 129) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 68))\n ((:tag . "CD") (:stem . "57.3") (:form . "57.3") (:end . 149) (:start . 145)\n  (:id . 69))\n ((:tag . "SYM") (:stem . "±") (:form . "±") (:end . 151) (:start . 150)\n  (:id . 70))\n ((:tag . "CD") (:stem . "11.0") (:form . "11.0") (:end . 156) (:start . 152)\n  (:id . 71))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 157) (:start . 156)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x303.10.1) (:span 116 118)))\n (:nscopes ((:id . :x303.10.1) (:span 116 158)))\n (:identifiers (:sid . :s303.10) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002764@unknown@formal@none@1@S@NK cell activity did not increase in patients with HER-2/neu overexpression.@(((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 75) (:start . 61) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x303.11.1) (:span 21 24)))\n (:nscopes ((:id . :x303.11.1) (:span 21 75)))\n (:identifiers (:sid . :s303.11) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002765@unknown@formal@none@1@S@Thus, there was a statistically significant correlation of cytolytic effector cell function with HER-2/neu expression of the tumor (P = 0.003), and HER-2/neu overexpression correlated with a negative estrogen receptor status (P = 0.005).@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 31) (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cytolytic") (:form . "cytolytic") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "CD") (:stem . "0.003") (:form . "0.003") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HER-2/neu") (:form . "HER-2/neu") (:end . 157)\n  (:start . 148) (:id . 68))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 172) (:start . 158) (:id . 69))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 183)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 199)\n  (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 208)\n  (:start . 200) (:id . 74))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 217)\n  (:start . 209) (:id . 75))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 224)\n  (:start . 218) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 226) (:start . 225)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 227) (:start . 226)\n  (:id . 78))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 229) (:start . 228)\n  (:id . 79))\n ((:tag . "CD") (:stem . "0.005") (:form . "0.005") (:end . 235)\n  (:start . 230) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 236) (:start . 235)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s303.12) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002766@unknown@formal@none@1@S@CONCLUSION .@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 12) (:start . 11)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s303.13) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002767@unknown@formal@none@1@S@These data add further evidence to previous observations from the authors' laboratory that certain tumor characteristics may be associated with reactions of the host with breast cancer.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "add") (:form . "add") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 120) (:start . 105) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 184)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x303.14.1) (:span 121 124)))\n (:hscopes ((:id . :x303.14.1) (:span 91 184)))\n (:identifiers (:sid . :s303.14) (:did . :|94101543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002768@unknown@formal@none@1@S@Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 37) (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "vanadate") (:form . "vanadate") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 127)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s304.1) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002770@unknown@formal@none@1@S@The regulatory role of protein tyrosine phosphatases (PTPases) in this process was explored by studying the effects of a powerful PTPase inhibitor, vanadate peroxide (pervanadate), on the activation cascade of Jurkat human leukaemic T-cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ptpas") (:form . "PTPases") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "ptpase") (:form . "PTPase") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "vanadate") (:form . "vanadate") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pervanadate") (:form . "pervanadate") (:end . 178)\n  (:start . 167) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 198)\n  (:start . 188) (:id . 75))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 206)\n  (:start . 199) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 216)\n  (:start . 210) (:id . 78))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 222)\n  (:start . 217) (:id . 79))\n ((:tag . "JJ") (:stem . "leukaemic") (:form . "leukaemic") (:end . 232)\n  (:start . 223) (:id . 80))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 240)\n  (:start . 233) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s304.3) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002771@unknown@formal@none@1@S@Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in tyrosine phosphorylation of cellular proteins, notably phospholipase C gamma 1.@(((:tag . "NNP") (:stem . "Pervanadate") (:form . "Pervanadate") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "lck") (:form . "lck") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fyn") (:form . "fyn") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4-") (:form . "4-") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "3-fold") (:form . "3-fold") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 147) (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "RB") (:stem . "notably") (:form . "notably") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 191) (:start . 178) (:id . 70))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 201) (:start . 200)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s304.4) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002772@unknown@formal@none@1@S@After this event, we observed a rise in intracellular Ca2+ concentration, corresponding to an influx.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 53) (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 72) (:start . 59) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 87)\n  (:start . 74) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s304.5) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002773@unknown@formal@none@1@S@This effect required surface expression of the CD45 PTPase and was not observed in CD45-deficient variants of Jurkat cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PTPase") (:form . "PTPase") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd45-deficient") (:form . "CD45-deficient")\n  (:end . 97) (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x304.6.1) (:span 67 70)))\n (:nscopes ((:id . :x304.6.1) (:span 63 122)))\n (:identifiers (:sid . :s304.6) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002774@unknown@formal@none@1@S@In the CD45-negative variant, the effect of pervanadate on tyrosine phosphorylation was globally decreased and some phosphorylated substrates were specifically missing.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cd45-negative") (:form . "CD45-negative")\n  (:end . 20) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pervanadate") (:form . "pervanadate") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 83) (:start . 68) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "globally") (:form . "globally") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 130) (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 159)\n  (:start . 147) (:id . 62))\n ((:tag . "JJ") (:stem . "missing") (:form . "missing") (:end . 167)\n  (:start . 160) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s304.7) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002775@unknown@formal@none@1@S@Pervanadate also stimulated transcription of the c-fos gene and accumulation of its mRNA as well as several other hallmarks of T-lymphocyte activation such as surface expression of the CD69 antigen and the interleukin 2 receptor alpha-chain (CD25).@(((:tag . "NNP") (:stem . "Pervanadate") (:form . "Pervanadate") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "hallmark") (:form . "hallmarks") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 139) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 177)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CD69") (:form . "CD69") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 197)\n  (:start . 190) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 217)\n  (:start . 206) (:id . 74))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 219) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 228)\n  (:start . 220) (:id . 76))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 240)\n  (:start . 229) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 242) (:start . 241)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cd25") (:form . "CD25") (:end . 246) (:start . 242)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 247) (:start . 246)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s304.8) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002776@unknown@formal@none@1@S@Pervanadate synergized with signals delivered by T-cell antigen receptor engagement or by a phorbol ester to induce interleukin 2 production.@(((:tag . "NNP") (:stem . "Pervanadate") (:form . "Pervanadate") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "synergize") (:form . "synergized") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "VBN") (:stem . "deliver") (:form . "delivered") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x304.9.1) (:span 84 86)))\n (:hscopes ((:id . :x304.9.1) (:span 46 105)))\n (:identifiers (:sid . :s304.9) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002777@unknown@formal@none@1@S@Pervanadate activated NF-kappa B, as shown by an increase in DNA-binding activity of this transcription factor.@(((:tag . "NNP") (:stem . "Pervanadate") (:form . "Pervanadate") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s304.10) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002778@unknown@formal@none@1@S@We thus conclude that PTPases play a crucial role in the negative regulation of signal transduction culminating in T-lymphocyte activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ptpas") (:form . "PTPases") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 99)\n  (:start . 87) (:id . 57))\n ((:tag . "VBG") (:stem . "culminate") (:form . "culminating") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 127) (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s304.11) (:did . :|94107268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002780@unknown@formal@none@1@S@Steroid-resistant asthma .@(((:tag . "JJ") (:stem . "steroid-resistant") (:form . "Steroid-resistant")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 24)\n  (:start . 18) (:id . 43))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 26) (:start . 25)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s305.1) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002781@unknown@formal@none@1@S@Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "contribute") (:form . "contributing") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inadequate") (:form . "inadequate") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 73) (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 81)\n  (:start . 74) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s305.2) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002782@unknown@formal@none@1@S@The current study examined whether alterations in glucocorticoid receptor (GR) binding contribute to poor response to glucocorticoid therapy in asthma.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 132) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x305.3.1) (:span 27 34)))\n (:hscopes ((:id . :x305.3.1) (:span 27 150)))\n (:identifiers (:sid . :s305.3) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002783@unknown@formal@none@1@S@29 asthma patients with forced expiratory volume in 1 s (FEV1) < 70% predicted were studied.@(((:tag . "CD") (:stem . "29") (:form . "29") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "force") (:form . "forced") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "expiratory") (:form . "expiratory") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "volume") (:form . "volume") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "s") (:form . "s") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "FEV1") (:form . "FEV1") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 78)\n  (:start . 69) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 91)\n  (:start . 84) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s305.4) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002784@unknown@formal@none@1@S@Patients were classified as steroid sensitive (SS) if their morning FEV1 increased > 30% after a 1-wk course of oral prednisone 20 mg twice daily and steroid resistant (SR) if they failed to increase > 15%.@(((:tag . "NNPS") (:stem . "Patient") (:form . "Patients") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "classify") (:form . "classified") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 59)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "morning") (:form . "morning") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "fev1") (:form . "FEV1") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "1-wk") (:form . "1-wk") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "prednisone") (:form . "prednisone") (:end . 127)\n  (:start . 117) (:id . 65))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mg") (:form . "mg") (:end . 133) (:start . 131)\n  (:id . 67))\n ((:tag . "RB") (:stem . "twice") (:form . "twice") (:end . 139)\n  (:start . 134) (:id . 68))\n ((:tag . "RB") (:stem . "daily") (:form . "daily") (:end . 145)\n  (:start . 140) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 157)\n  (:start . 150) (:id . 71))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 167)\n  (:start . 158) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "SR") (:form . "SR") (:end . 171) (:start . 169)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 75))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 175) (:start . 173)\n  (:id . 76))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 180) (:start . 176)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 187)\n  (:start . 181) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 79))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 199)\n  (:start . 191) (:id . 80))\n ((:tag . "JJR") (:stem . ">") (:form . ">") (:end . 201) (:start . 200)\n  (:id . 81))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 204) (:start . 202)\n  (:id . 82))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 205) (:start . 204)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s305.5) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002785@unknown@formal@none@1@S@PBMC obtained from these two groups, 17 SR and 12 SS, as well as 12 normal controls were analyzed.@(((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sr") (:form . "SR") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 61) (:start . 57)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 57))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 67) (:start . 65)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 74)\n  (:start . 68) (:id . 59))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 83)\n  (:start . 75) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 97)\n  (:start . 89) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s305.6) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002786@unknown@formal@none@1@S@SR patients had two distinguishable GR binding abnormalities:@(((:tag . "NNP") (:stem . "SR") (:form . "SR") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinguishable") (:form . "distinguishable")\n  (:end . 35) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 60)\n  (:start . 47) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 61) (:start . 60)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s305.7) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002787@unknown@formal@none@1@S@15 of the 17 SR patients demonstrated a significantly reduced GR binding affinity, as compared with SS patients (P = 0.0001) and normal controls (P = 0.0001).@(((:tag . "CD") (:stem . "15") (:form . "15") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sr") (:form . "SR") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 37)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 53) (:start . 40) (:id . 50))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ss") (:form . "SS") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CD") (:stem . "0.0001") (:form . "0.0001") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 135)\n  (:start . 129) (:id . 67))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 144)\n  (:start . 136) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 149) (:start . 148)\n  (:id . 71))\n ((:tag . "CD") (:stem . "0.0001") (:form . "0.0001") (:end . 156)\n  (:start . 150) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s305.8) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002788@unknown@formal@none@1@S@This defect was localized to T cells and reverted to normal after 48 h in culture media.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "revert") (:form . "reverted") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 87)\n  (:start . 82) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s305.9) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002790@unknown@formal@none@1@S@The other two SR patients had an abnormally low GR number with normal binding affinity that was not limited to T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "sr") (:form . "SR") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "abnormally") (:form . "abnormally") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x305.11.1) (:span 96 99)))\n (:nscopes ((:id . :x305.11.1) (:span 96 118)))\n (:identifiers (:sid . :s305.11) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002791@unknown@formal@none@1@S@Furthermore, GR number failed to normalize after incubation in media alone or IL-2 and IL-4.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 29) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "normalize") (:form . "normalize") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 68)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s305.12) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002792@unknown@formal@none@1@S@Therefore, SR asthma may be due to more than one abnormality, the majority related to a reversible cytokine-induced reduction in GR binding affinity and the second related to an irreversible reduction in GR number.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SR") (:form . "SR") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 60)\n  (:start . 49) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 98)\n  (:start . 88) (:id . 60))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 115) (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 139)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 163)\n  (:start . 157) (:id . 69))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 190)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 200)\n  (:start . 191) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 213)\n  (:start . 207) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x305.13.1) (:span 21 24)))\n (:hscopes ((:id . :x305.13.1) (:span 21 213)))\n (:identifiers (:sid . :s305.13) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002793@unknown@formal@none@1@S@These findings may have important implications for the design of alternative treatment approaches for recalcitrant asthma.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "recalcitrant") (:form . "recalcitrant") (:end . 114)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x305.14.1) (:span 15 18)))\n (:hscopes ((:id . :x305.14.1) (:span 15 121)))\n (:identifiers (:sid . :s305.14) (:did . :|94110342|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002794@unknown@formal@none@1@S@Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic transcription factors.@(((:tag . "NNPS") (:stem . "Rhabdomyosarcoma") (:form . "Rhabdomyosarcomas")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 20) (:start . 18)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "myogenic") (:form . "myogenic") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x306.1.1) (:span 21 24)))\n (:nscopes ((:id . :x306.1.1) (:span 21 103)))\n (:identifiers (:sid . :s306.1) (:did . :|94110361|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002795@unknown@formal@none@1@S@Skeletal myogenesis is regulated by a group of transcription factors (MyoD, myogenin, myf5, and myf6) that are " basic helix-loop-helix " proteins that bind to the promoters of muscle-specific genes and promote their expression.@(((:tag . "JJ") (:stem . "skeletal") (:form . "Skeletal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "myogenesis") (:form . "myogenesis") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MyoD") (:form . "MyoD") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "myogenin") (:form . "myogenin") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "myf5") (:form . "myf5") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "myf6") (:form . "myf6") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 112) (:start . 111)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 118)\n  (:start . 113) (:id . 65))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 135) (:start . 119) (:id . 66))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 173)\n  (:start . 164) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "muscle-specific") (:form . "muscle-specific")\n  (:end . 192) (:start . 177) (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 198)\n  (:start . 193) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 77))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 210)\n  (:start . 203) (:id . 78))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 216)\n  (:start . 211) (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 227)\n  (:start . 217) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s306.2) (:did . :|94110361|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002796@unknown@formal@none@1@S@We have previously shown that after a mutation of Leu122 to Arg the DNA binding basic domain of MyoD confers c-myc-like functional characteristics to the protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "leu122") (:form . "Leu122") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "arg") (:form . "Arg") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MyoD") (:form . "MyoD") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "JJ") (:stem . "c-myc-like") (:form . "c-myc-like") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 130)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 146) (:start . 131) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s306.3) (:did . :|94110361|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002797@unknown@formal@none@1@S@In this study we used single-strand conformation polymorphism analysis to determine whether such mutations occur naturally in rhabdomyosarcomas.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "single-strand") (:form . "single-strand")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "rhabdomyosarcoma") (:form . "rhabdomyosarcomas")\n  (:end . 143) (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x306.4.1) (:span 84 91)))\n (:hscopes ((:id . :x306.4.1) (:span 84 143)))\n (:identifiers (:sid . :s306.4) (:did . :|94110361|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002798@unknown@formal@none@1@S@We have found that the basic domains of all the myogenic factors remain unaltered in rhabdomyosarcomas.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "myogenic") (:form . "myogenic") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "rhabdomyosarcoma") (:form . "rhabdomyosarcomas")\n  (:end . 102) (:start . 85) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s306.5) (:did . :|94110361|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002800@unknown@formal@none@1@S@Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3) [published erratum appears in J Immunol 1994 Jul 15;153 ( 2 ):910]@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "ganglioside") (:form . "ganglioside") (:end . 146)\n  (:start . 135) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GD3") (:form . "GD3") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 163)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 179)\n  (:start . 172) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Immunol") (:form . "Immunol") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "CD") (:stem . "1994") (:form . "1994") (:end . 197) (:start . 193)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Jul") (:form . "Jul") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "CD") (:stem . "15;153") (:form . "15;153") (:end . 208)\n  (:start . 202) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 75))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 212) (:start . 211)\n  (:id . 76))\n ((:tag . "CD") (:stem . "):910") (:form . "):910") (:end . 218)\n  (:start . 213) (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 219) (:start . 218)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s307.1) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002801@unknown@formal@none@1@S@Previous studies have suggested that gangliosides have an important role in cell signaling and recognition.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x307.2.1) (:span 22 31)))\n (:hscopes ((:id . :x307.2.1) (:span 22 106)))\n (:identifiers (:sid . :s307.2) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002802@unknown@formal@none@1@S@However, their specific function in these processes has not been clearly defined.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x307.3.1) (:span 56 59)))\n (:nscopes ((:id . :x307.3.1) (:span 9 80)))\n (:identifiers (:sid . :s307.3) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002803@unknown@formal@none@1@S@A mAb, R24, that reacts specifically with a cell surface ganglioside (GD3) has been demonstrated to stimulate proliferation of T cells derived from human peripheral blood.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 44))\n ((:tag . "NNP") (:stem . "R24") (:form . "R24") (:end . 10) (:start . 7)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "react") (:form . "reacts") (:end . 23)\n  (:start . 17) (:id . 48))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 36)\n  (:start . 24) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 56)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "ganglioside") (:form . "ganglioside") (:end . 68)\n  (:start . 57) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GD3") (:form . "GD3") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 96)\n  (:start . 84) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 109)\n  (:start . 100) (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 123) (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 142)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 153)\n  (:start . 148) (:id . 69))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 164)\n  (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s307.4) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002804@unknown@formal@none@1@S@In this study, we have investigated the mechanisms by which the R24 mAb affects T cell functions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 96)\n  (:start . 87) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s307.5) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002805@unknown@formal@none@1@S@We have observed that the R24 mAb stimulates GD3+ T cell proliferation, cytotoxicity, and surface marker expression of IL-2R alpha-chain, IL-2R beta-chain, HLA-DR, CD11a, and CD11c.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "gd3+") (:form . "GD3+") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 84)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 154)\n  (:start . 144) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 162)\n  (:start . 156) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CD11a") (:form . "CD11a") (:end . 169)\n  (:start . 164) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CD11c") (:form . "CD11c") (:end . 180)\n  (:start . 175) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s307.6) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002806@unknown@formal@none@1@S@Additionally, IFN-gamma activity but not IL-1, IL-2, or IL-4 activity was present in culture supernatants 72 h after R24 stimulation.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 132)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x307.7.1) (:span 37 40)))\n (:nscopes ((:id . :x307.7.1) (:span 37 69)))\n (:identifiers (:sid . :s307.7) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002807@unknown@formal@none@1@S@In some donors, increased IL-6 and TNF-alpha activity also was detected after R24 treatment.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s307.8) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002808@unknown@formal@none@1@S@Furthermore, R24 treatment resulted in translocation of c-rel, but little or no NF kappa B p50 or p65, from the cytoplasm to the nucleus and an increase of NF kappa B binding complexes containing c-rel and p50.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 121)\n  (:start . 112) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 136)\n  (:start . 129) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 143) (:start . 141)\n  (:id . 70))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 152)\n  (:start . 144) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 158) (:start . 156)\n  (:id . 73))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 164)\n  (:start . 159) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 166) (:start . 165)\n  (:id . 75))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 174)\n  (:start . 167) (:id . 76))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 184)\n  (:start . 175) (:id . 77))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 195)\n  (:start . 185) (:id . 78))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 201)\n  (:start . 196) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 80))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 209) (:start . 206)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x307.9.2) (:span 74 76)))\n (:ncues ((:id . :x307.9.1) (:span 77 79)))\n (:hscopes ((:id . :x307.9.2) (:span 67 101)))\n (:nscopes ((:id . :x307.9.1) (:span 77 101)))\n (:identifiers (:sid . :s307.9) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002810@unknown@formal@none@1@S@R24-stimulated increases in proliferation, cytotoxicity, and cell surface protein expression could be blocked by cyclosporin and staurosporin, indicating that cyclophilin/calcineurin and protein kinase C may be involved in the R24 signaling pathway.@(((:tag . "JJ") (:stem . "r24-stimulated") (:form . "R24-stimulated")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 41) (:start . 28) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 55)\n  (:start . 43) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "staurosporin") (:form . "staurosporin") (:end . 141)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 153)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cyclophilin/calcineurin")\n  (:form . "cyclophilin/calcineurin") (:end . 182) (:start . 159) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 194)\n  (:start . 187) (:id . 66))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 201)\n  (:start . 195) (:id . 67))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 203) (:start . 202)\n  (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 207) (:start . 204)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 210) (:start . 208)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 219)\n  (:start . 211) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 73))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 230) (:start . 227)\n  (:id . 74))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 240)\n  (:start . 231) (:id . 75))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 248)\n  (:start . 241) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x307.11.1) (:span 204 207))\n  ((:id . :x307.11.2) (:span 143 158)) ((:id . :x307.11.3) (:span 93 98)))\n (:hscopes ((:id . :x307.11.1) (:span 159 248))\n  ((:id . :x307.11.2) (:span 143 248)) ((:id . :x307.11.3) (:span 0 141)))\n (:identifiers (:sid . :s307.11) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002811@unknown@formal@none@1@S@Additionally, herbimycin A, a tyrosine kinase inhibitor, blocked the R24-stimulated increase in proliferation but not cytotoxicity at concentrations consistent with specificity for tyrosine kinases.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "r24-stimulated") (:form . "R24-stimulated")\n  (:end . 83) (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 109) (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 130)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 148) (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 64))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 176)\n  (:start . 165) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 180) (:start . 177)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 189)\n  (:start . 181) (:id . 67))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 197)\n  (:start . 190) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x307.12.1) (:span 114 117)))\n (:nscopes ((:id . :x307.12.1) (:span 114 130)))\n (:identifiers (:sid . :s307.12) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002812@unknown@formal@none@1@S@These results suggest that multiple biochemical pathways are involved in the activation of human T cells by R24.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "r24") (:form . "R24") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x307.13.1) (:span 14 21)))\n (:hscopes ((:id . :x307.13.1) (:span 14 111)))\n (:identifiers (:sid . :s307.13) (:did . :|94110603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002813@unknown@formal@none@1@S@The SCL protein displays cell-specific heterogeneity in size.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "heterogeneity") (:form . "heterogeneity")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s308.1) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002814@unknown@formal@none@1@S@SCL protein production was examined in a variety of hemopoietic cell lines by immunoblotting using specific polyclonal antisera.@(((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunoblotting") (:form . "immunoblotting")\n  (:end . 92) (:start . 78) (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "antiserum") (:form . "antisera") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s308.2) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002815@unknown@formal@none@1@S@SCL protein was detected in erythroid, megakaryocyte, mast and early myeloid cell lines, as well as in several lymphoid leukemia cell lines which are known to harbor SCL gene rearrangements.@(((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "VB") (:stem . "harbor") (:form . "harbor") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 189) (:start . 175) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s308.3) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002816@unknown@formal@none@1@S@In most cell lines, proteins of molecular weight 49 and 44 kDa were found, however two myeloid cell lines expressed only lower molecular weight species of 24 and 22 kDa.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "CD") (:stem . "49") (:form . "49") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 82)\n  (:start . 75) (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 94)\n  (:start . 87) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 105)\n  (:start . 100) (:id . 62))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 115)\n  (:start . 106) (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 126) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 71))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 168) (:start . 165)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s308.4) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002817@unknown@formal@none@1@S@This size discrepancy appeared to be due to cell-specific translational regulation, since overexpression of a retrovirally transfected SCL gene yielded the higher molecular weight forms in most cell lines (GP+E-86, AT2.5, M1) but only the 22 kDa form in the myeloid cell line, WEHI-3B/D+.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "discrepancy") (:form . "discrepancy") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 104) (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "RB") (:stem . "retrovirally") (:form . "retrovirally") (:end . 122)\n  (:start . 110) (:id . 58))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 134)\n  (:start . 123) (:id . 59))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "yield") (:form . "yielded") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 172)\n  (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 179)\n  (:start . 173) (:id . 66))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 185)\n  (:start . 180) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 68))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 193) (:start . 189)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 198) (:start . 194)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 204)\n  (:start . 199) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GP+E-86") (:form . "GP+E-86") (:end . 213)\n  (:start . 206) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "AT2.5") (:form . "AT2.5") (:end . 220)\n  (:start . 215) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "M1") (:form . "M1") (:end . 224) (:start . 222)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 225) (:start . 224)\n  (:id . 78))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 229) (:start . 226)\n  (:id . 79))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 234) (:start . 230)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 81))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 241) (:start . 239)\n  (:id . 82))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 245) (:start . 242)\n  (:id . 83))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 250) (:start . 246)\n  (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 253) (:start . 251)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 257) (:start . 254)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 265)\n  (:start . 258) (:id . 87))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 270) (:start . 266)\n  (:id . 88))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 275) (:start . 271)\n  (:id . 89))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 276) (:start . 275)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "wehi-3b/d+") (:form . "WEHI-3B/D+") (:end . 287)\n  (:start . 277) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 92)))@@@1@51@((:hcues ((:id . :x308.5.1) (:span 22 30)))\n (:hscopes ((:id . :x308.5.1) (:span 0 82)))\n (:identifiers (:sid . :s308.5) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002818@unknown@formal@none@1@S@Overexpression of full-length SCL protein in the lymphoid cell lines, SupT1 and Raji, did not alter cell phenotype and there was no evidence for autoregulation of SCL transcription.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SupT1") (:form . "SupT1") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 140)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 159) (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 180) (:start . 167) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x308.6.1) (:span 129 131))\n  ((:id . :x308.6.2) (:span 90 93)))\n (:nscopes ((:id . :x308.6.1) (:span 129 180))\n  ((:id . :x308.6.2) (:span 90 114)))\n (:identifiers (:sid . :s308.6) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002820@unknown@formal@none@1@S@In addition, the present results indicate that SCL protein size was determined by regulation of translation in a cell-specific manner.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 126) (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x308.8.1) (:span 33 46)))\n (:hscopes ((:id . :x308.8.1) (:span 33 133)))\n (:identifiers (:sid . :s308.8) (:did . :|94118533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002821@unknown@formal@none@1@S@Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 40) (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 59) (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 95)\n  (:start . 87) (:id . 52))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 107)\n  (:start . 96) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 115)\n  (:start . 108) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 55))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 124)\n  (:start . 119) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 147) (:start . 134) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 155)\n  (:start . 148) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s309.1) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002822@unknown@formal@none@1@S@The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene has been studied extensively as a model system of transcriptional induction during T-lymphocyte activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 26) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 45) (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 60)\n  (:start . 54) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 95)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 132) (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 142)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 149)\n  (:start . 143) (:id . 61))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 162) (:start . 150) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s309.2) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002823@unknown@formal@none@1@S@The GM-CSF gene is not expressed in resting peripheral blood T cells but is rapidly induced at the transcriptional level following activation through the cell surface T-cell receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 114) (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 166)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 173)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 182)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x309.3.1) (:span 19 22)))\n (:nscopes ((:id . :x309.3.1) (:span 19 68)))\n (:identifiers (:sid . :s309.3) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002824@unknown@formal@none@1@S@A highly conserved 19-bp element located immediately 5' of the human GM-CSF TATA box (bp -34 to -52), herein called purine box 1 (PB1), has been shown to bind a T-cell nuclear protein complex and to be required for transcriptional induction of the GM-CSF gene following T-cell activation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "19-bp") (:form . "19-bp") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "RB") (:stem . "immediately") (:form . 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"nuclear") (:end . 175)\n  (:start . 168) (:id . 80))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 183)\n  (:start . 176) (:id . 81))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 191)\n  (:start . 184) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 198) (:start . 196)\n  (:id . 84))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 201) (:start . 199)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 210)\n  (:start . 202) (:id . 86))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 214) (:start . 211)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 230) (:start . 215) (:id . 88))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 240)\n  (:start . 231) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 254)\n  (:start . 248) (:id . 92))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 259) (:start . 255)\n  (:id . 93))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 269)\n  (:start . 260) (:id . 94))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 276)\n  (:start . 270) (:id . 95))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 287)\n  (:start . 277) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s309.4) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002825@unknown@formal@none@1@S@The PB1 sequence motif is highly conserved in both human and murine GM-CSF genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pb1") (:form . "PB1") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s309.5) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002826@unknown@formal@none@1@S@In this report, we demonstrate that the PB1 element alone confers inducibility on a heterologous promoter following transfection into human Jurkat T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pb1") (:form . "PB1") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 78)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 96)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s309.6) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002827@unknown@formal@none@1@S@In addition, we identify a major PB1 nuclear protein-binding complex that is not present in resting peripheral blood T cells but is rapidly induced following T-cell activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pb1") (:form . "PB1") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "protein-binding") (:form . "protein-binding")\n  (:end . 60) (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 139)\n  (:start . 132) (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 175)\n  (:start . 165) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x309.7.1) (:span 77 80)))\n (:nscopes ((:id . :x309.7.1) (:span 77 124)))\n (:identifiers (:sid . :s309.7) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002828@unknown@formal@none@1@S@Sequence analysis revealed that PB1 is composed of adjacent binding sites for Ets and AP-1 transcription factors.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pb1") (:form . "PB1") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s309.8) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002830@unknown@formal@none@1@S@(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "abstract") (:form . "ABSTRACT") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s309.10) (:did . :|94119067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002831@unknown@formal@none@1@S@Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product:@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s310.1) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002832@unknown@formal@none@1@S@implications for viral latency.@(((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 31) (:start . 30)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s310.2) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002833@unknown@formal@none@1@S@Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "etiologic") (:form . "etiologic") (:end . 60)\n  (:start . 51) (:id . 53))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "aggressive") (:form . "aggressive") (:end . 110)\n  (:start . 100) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "JJ") (:stem . "fatal") (:form . "fatal") (:end . 126)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "malignancy") (:form . "malignancy") (:end . 137)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 150)\n  (:start . 141) (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 162) (:start . 161)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s310.3) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002834@unknown@formal@none@1@S@HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes.@(((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "40-kda") (:form . "40-kDa") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 49) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "transactivate") (:form . "transactivates")\n  (:end . 82) (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "retrovirus") (:form . "retrovirus") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "array") (:form . "array") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s310.4) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002835@unknown@formal@none@1@S@Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors.@(((:tag . "JJ") (:stem . "tax-mediated") (:form . "Tax-mediated") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 27) (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "deregulate") (:form . "deregulated") (:end . 70)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 56))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 130)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 141)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 148)\n  (:start . 142) (:id . 60))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 157)\n  (:start . 149) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 168)\n  (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 177)\n  (:start . 169) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 188)\n  (:start . 181) (:id . 66))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 199)\n  (:start . 189) (:id . 67))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 204) (:start . 200)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 218) (:start . 205) (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 226)\n  (:start . 219) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x310.5.1) (:span 39 45)))\n (:hscopes ((:id . :x310.5.1) (:span 39 226)))\n (:identifiers (:sid . :s310.5) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002836@unknown@formal@none@1@S@In particular, Tax is capable of modulating the expression or activity of various host transcription factors, including members of the NF-kappa B/Rel and CREB/ATF families, as well as the cellular factors HEB-1 and p67SRF.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 162)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 196)\n  (:start . 188) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 204)\n  (:start . 197) (:id . 75))\n ((:tag . "NN") (:stem . "heb-1") (:form . "HEB-1") (:end . 210)\n  (:start . 205) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "p67SRF") (:form . "p67SRF") (:end . 221)\n  (:start . 215) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s310.6) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002837@unknown@formal@none@1@S@An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "distinguishing") (:form . "distinguishing")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 43) (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 53)\n  (:start . 47) (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 133)\n  (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 150)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s310.7) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002838@unknown@formal@none@1@S@In this study, we demonstrate that HTLV-I Tax can physically associate with p100, the product of the Rel-related NF-kappa B2 gene, both in transfected cells and in HTLV-I-infected leukemic T-cell lines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "rel-related") (:form . "Rel-related") (:end . 112)\n  (:start . 101) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 150)\n  (:start . 139) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "htlv-i-infected") (:form . "HTLV-I-infected")\n  (:end . 179) (:start . 164) (:id . 72))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 188)\n  (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 195)\n  (:start . 189) (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 201)\n  (:start . 196) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s310.8) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002840@unknown@formal@none@1@S@In contrast, a mutant of Tax that selectively fails to activate nuclear NF-kappa B expression does not associate with p100.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 21)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 45)\n  (:start . 34) (:id . 50))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x310.10.1) (:span 99 102)))\n (:nscopes ((:id . :x310.10.1) (:span 99 122)))\n (:identifiers (:sid . :s310.10) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002841@unknown@formal@none@1@S@(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "abstract") (:form . "ABSTRACT") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s310.11) (:did . :|94119088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002842@unknown@formal@none@1@S@Regulation of the BZLF1 promoter of Epstein-Barr virus by second messengers in anti-immunoglobulin-treated B cells.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-immunoglobulin-treated")\n  (:form . "anti-immunoglobulin-treated") (:end . 106) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s311.1) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002843@unknown@formal@none@1@S@Initiation of the Epstein-Barr virus (EBV) lytic cycle is dependent on the transcription of the BZLF1 gene.@(((:tag . "NN") (:stem . "initiation") (:form . "Initiation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s311.2) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002844@unknown@formal@none@1@S@The BZLF1 gene promoter (Zp) was activated by crosslinking of cell surface immunoglobulin (Ig) with anti-Ig antibody in B cells, even in the absence of other viral genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "crosslinking") (:form . "crosslinking") (:end . 58)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 89) (:start . 75) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 69))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 148)\n  (:start . 141) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 157)\n  (:start . 152) (:id . 72))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 163)\n  (:start . 158) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 169)\n  (:start . 164) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s311.3) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002845@unknown@formal@none@1@S@We identified several anti-Ig response elements within Zp, which were originally defined as 12-O-tetradecanoylphorbol-13-acetate (TPA) response elements (ZI repeats and ZII, an AP-1-like domain).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 128) (:start . 92)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 133) (:start . 130)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ZI") (:form . "ZI") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "ZII") (:form . "ZII") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "ap-1-like") (:form . "AP-1-like") (:end . 186)\n  (:start . 177) (:id . 69))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 193)\n  (:start . 187) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s311.4) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002846@unknown@formal@none@1@S@Since anti-Ig crosslinking leads to activation of protein kinase C (PKC) and an increase in intracellular calcium level, Zp was tested for the response to these cellular factors.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "crosslinking") (:form . "crosslinking") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 105) (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 134)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 151)\n  (:start . 143) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 160)\n  (:start . 155) (:id . 70))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 169)\n  (:start . 161) (:id . 71))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 177)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s311.5) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002847@unknown@formal@none@1@S@Treatment with calcium ionophore A23187 increased Zp activity.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "a23187") (:form . "A23187") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s311.6) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002848@unknown@formal@none@1@S@When the calcium ionophore was used in conjunction with TPA, a PKC activator, the Zp induction was synergistically enhanced.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 114) (:start . 99) (:id . 61))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s311.7) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002850@unknown@formal@none@1@S@Calmodulin antagonists, compound R24571 and trifluoperazine, blocked the Zp activation with anti-Ig.@(((:tag . "NNP") (:stem . "Calmodulin") (:form . "Calmodulin") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "r24571") (:form . "R24571") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "trifluoperazine") (:form . "trifluoperazine")\n  (:end . 59) (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "zp") (:form . "Zp") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s311.9) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002851@unknown@formal@none@1@S@These findings suggest that Zp responds directly to changes in the activity of both PKC and calcium/calmodulin-dependent protein kinase.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "calcium/calmodulin-dependent")\n  (:form . "calcium/calmodulin-dependent") (:end . 120) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x311.10.1) (:span 15 22)))\n (:hscopes ((:id . :x311.10.1) (:span 15 135)))\n (:identifiers (:sid . :s311.10) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002852@unknown@formal@none@1@S@Requirement of tyrosine kinase activation for the anti-Ig-mediated Zp activation was also demonstrated through the use of the tyrosine kinase inhibitor herbimycin.@(((:tag . "NN") (:stem . "requirement") (:form . "Requirement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-ig-mediated") (:form . "anti-Ig-mediated")\n  (:end . 66) (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "Zp") (:form . "Zp") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 102)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s311.11) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002853@unknown@formal@none@1@S@These cellular gene regulatory molecules induced with anti-Ig may cooperatively play an important part in achieving efficient EBV activation as seen with anti-Ig treatment in B cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "RB") (:stem . "cooperatively") (:form . "cooperatively")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "achieve") (:form . "achieving") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 140)\n  (:start . 130) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "anti-ig") (:form . "anti-Ig") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x311.12.1) (:span 62 65)))\n (:hscopes ((:id . :x311.12.1) (:span 62 182)))\n (:identifiers (:sid . :s311.12) (:did . :|94120719|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002854@unknown@formal@none@1@S@Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "downmodulate") (:form . "downmodulates")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 53) (:start . 38) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata1") (:form . "GATA1") (:end . 63) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "JJ") (:stem . "adult-progenitor") (:form . "adult-progenitor")\n  (:end . 103) (:start . 87) (:id . 52))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 111)\n  (:start . 104) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s312.1) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002855@unknown@formal@none@1@S@All-trans retinoic acid (RA) is an important morphogen in vertebrate development, a normal constituent in human adult blood and is also involved in the control of cell growth and differentiation in acute promyelocytic leukemia.@(((:tag . "JJ") (:stem . "all-trans") (:form . "All-trans") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "morphogen") (:form . "morphogen") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "constituent") (:form . "constituent") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 174)\n  (:start . 168) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 194) (:start . 179) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 203)\n  (:start . 198) (:id . 76))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 217) (:start . 204) (:id . 77))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 226)\n  (:start . 218) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s312.2) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002856@unknown@formal@none@1@S@We have examined the effects of RA on normal hematopoiesis by using early hematopoietic progenitor cells (HPC) stringently purified from adult peripheral blood.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 58) (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 87) (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "RB") (:stem . "stringently") (:form . "stringently") (:end . 122)\n  (:start . 111) (:id . 61))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s312.3) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002857@unknown@formal@none@1@S@In clonogenetic fetal calf serum-supplemented (FCS+) or -nonsupplemented (FCS-) culture treated with saturating levels of interleukin-3 (IL-3) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Ep) (combined with c-kit ligand in FCS(-)-culture conditions), RA induces a dramatic dose-dependent shift from erythroid to granulomonocytic colony formation, the latter colonies being essentially represented by granulocytic clones.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "clonogenetic") (:form . "clonogenetic") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "calf") (:form . "calf") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "serum-supplemented") (:form . "serum-supplemented")\n  (:end . 45) (:start . 27) (:id . 46))\n ((:tag . 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5002858@unknown@formal@none@1@S@This shift is apparently not caused by a recruitment phenomenon, because in FCS+ culture, the total number of colonies is not significantly modified by RA addition.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "fcs+") (:form . "FCS+") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 139) (:start . 126) (:id . 65))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x312.5.1) (:span 14 24)))\n (:ncues ((:id . :x312.5.2) (:span 25 28)))\n (:hscopes ((:id . :x312.5.1) (:span 0 63)))\n (:nscopes ((:id . :x312.5.2) (:span 0 63)))\n (:identifiers (:sid . :s312.5) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002860@unknown@formal@none@1@S@Here again, treatment with high-dose RA induces a shift from the erythroid to granulocytic differentiation pathway.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high-dose") (:form . "high-dose") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 90)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 106) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s312.7) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002861@unknown@formal@none@1@S@Studies on RA time-response or pulse treatment in semisolid or liquid culture show that early RA addition is most effective, thus indicating that early but not late HPC are sensitive to its action.@(((:tag . "NNPS") (:stem . "Study") (:form . "Studies") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "time-response") (:form . "time-response")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pulse") (:form . "pulse") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "semisolid") (:form . "semisolid") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "liquid") (:form . "liquid") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 140)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 189) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 196)\n  (:start . 190) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x312.8.2) (:span 130 145)))\n (:ncues ((:id . :x312.8.1) (:span 156 159)))\n (:hscopes ((:id . :x312.8.2) (:span 130 196)))\n (:nscopes ((:id . :x312.8.1) (:span 156 164)))\n (:identifiers (:sid . :s312.8) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002862@unknown@formal@none@1@S@We then analyzed the expression of the master GATA1 gene, which encodes a finger transcription factor required for normal erythroid development;@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "master") (:form . "master") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "gata1") (:form . "GATA1") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s312.9) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002863@unknown@formal@none@1@S@addition of RA to HPC stimulated into unilineage erythropoietic differentiation in liquid culture caused a virtually complete inhibition of GATA1 mRNA induction.@(((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unilineage") (:form . "unilineage") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "erythropoietic") (:form . "erythropoietic")\n  (:end . 63) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 79) (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "liquid") (:form . "liquid") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 136)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata1") (:form . "GATA1") (:end . 145)\n  (:start . 140) (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 160)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s312.10) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002864@unknown@formal@none@1@S@These results indicate that RA directly inhibits the erythroid differentiation program at the level of early adult HPC, and may lead to a shift from the erythroid to granulocytic differentiation pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 78) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 162)\n  (:start . 153) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 178)\n  (:start . 166) (:id . 71))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 194) (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x312.11.1) (:span 124 127))\n  ((:id . :x312.11.2) (:span 14 27)))\n (:hscopes ((:id . :x312.11.1) (:span 124 202))\n  ((:id . :x312.11.2) (:span 14 202)))\n (:identifiers (:sid . :s312.11) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002865@unknown@formal@none@1@S@This phenomenon is correlated with inhibition of GATA1 induction in the early stages of erythropoietic differentiation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata1") (:form . "GATA1") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "erythropoietic") (:form . "erythropoietic")\n  (:end . 102) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 118) (:start . 103) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s312.12) (:did . :|94129004|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002866@unknown@formal@none@1@S@Effects of CD45 on NF-kappa B.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s313.1) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002867@unknown@formal@none@1@S@Implications for replication of HIV-1.@(((:tag . "NNS") (:stem . "implication") (:form . "Implications") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s313.2) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002868@unknown@formal@none@1@S@Increased levels of replication of the HIV type 1 are observed after the activation of infected T cells through the TCR.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s313.3) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002870@unknown@formal@none@1@S@In this study, we examined interrelationships between CD45 and HIV-1 further.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "NNS") (:stem . "interrelationship") (:form . "interrelationships")\n  (:end . 45) (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s313.5) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002871@unknown@formal@none@1@S@We measured effects on the HIV-1 LTR in T cell lines that were stimulated with antibodies against CD45 and in those that lacked the expression of CD45 on their surfaces.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 73)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "lack") (:form . "lacked") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 159)\n  (:start . 154) (:id . 70))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x313.6.1) (:span 121 127)))\n (:nscopes ((:id . :x313.6.1) (:span 121 168)))\n (:identifiers (:sid . :s313.6) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002872@unknown@formal@none@1@S@First, anti-CD45 antibodies did not affect basal but decreased activated levels of expression from the HIV-1 LTR.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "anti-cd45") (:form . "anti-CD45") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x313.7.1) (:span 32 35)))\n (:nscopes ((:id . :x313.7.1) (:span 32 48)))\n (:identifiers (:sid . :s313.7) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002873@unknown@formal@none@1@S@Second, T cells, which lack CD45 and can not signal via the TCR, supported higher levels of viral replication and gene expression.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . "VB") (:stem . "signal") (:form . "signal") (:end . 51)\n  (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "support") (:form . "supported") (:end . 74)\n  (:start . 65) (:id . 58))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 81) (:start . 75)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 88)\n  (:start . 82) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 97) (:start . 92)\n  (:id . 62))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 109)\n  (:start . 98) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x313.8.1) (:span 41 44)) ((:id . :x313.8.2) (:span 23 27)))\n (:nscopes ((:id . :x313.8.1) (:span 41 63))\n  ((:id . :x313.8.2) (:span 23 32)))\n (:identifiers (:sid . :s313.8) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002874@unknown@formal@none@1@S@This was due to the presence of active NF-kappa B complexes in the nucleus of CD45- T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd45-") (:form . "CD45-") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s313.9) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002875@unknown@formal@none@1@S@Additionally, infected T cells displayed lower levels of CD45 on their surfaces.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 70)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s313.10) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002876@unknown@formal@none@1@S@Thus, CD45 plays an active role in the physiology of T cells and in the replication of HIV-1.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "physiology") (:form . "physiology") (:end . 49)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 83)\n  (:start . 72) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 92) (:start . 87)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s313.11) (:did . :|94132650|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002877@unknown@formal@none@1@S@Induction of phosphatidylinositol turnover and EGR-1 mRNA expression by crosslinking of surface IgM and IgD in the human B cell line B104.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 33) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 42)\n  (:start . 34) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 46))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "crosslinking") (:form . "crosslinking") (:end . 84)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "NNP") (:stem . "IgM") (:form . "IgM") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IgD") (:form . "IgD") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "b104") (:form . "B104") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s314.1) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002878@unknown@formal@none@1@S@We have previously shown that a human B lymphoma cell line, B104, expressed surface IgM (sIgM) and surface IgD (sIgD), and that crosslinking of sIgM and sIgD by anti-IgM antibody (Ab) and anti-IgD Ab, respectively, induced Ca2+ influx to almost the same degree, whereas only sIgM-crosslinking caused B104 cell death.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . 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5002880@unknown@formal@none@1@S@Both sIgM- and sIgD-crosslinking with antibodies induced elevation of cAMP levels, phosphatidylinositol turnover, PKC activation and expression of Egr-1 and c-fos mRNA, although sIgM-crosslinking was more effective than sIgD-crosslinking, presumably due to the higher expression of sIgM than of sIgD.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sigm-") (:form . "sIgM-") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sigd-crosslinking") (:form . "sIgD-crosslinking")\n  (:end . 32) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 103) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 112)\n  (:start . 104) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 162)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 177)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "sigm-crosslinking") (:form . "sIgM-crosslinking")\n  (:end . 195) (:start . 178) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 199) (:start . 196)\n  (:id . 69))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 204) (:start . 200)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 214)\n  (:start . 205) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 219) (:start . 215)\n  (:id . 72))\n ((:tag . "NN") (:stem . "sigd-crosslinking") (:form . "sIgD-crosslinking")\n  (:end . 237) (:start . 220) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 74))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 249)\n  (:start . 239) (:id . 75))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 253) (:start . 250)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 256) (:start . 254)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 260) (:start . 257)\n  (:id . 78))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 267)\n  (:start . 261) (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 278)\n  (:start . 268) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 281) (:start . 279)\n  (:id . 81))\n ((:tag . "NN") (:stem . "sigm") (:form . "sIgM") (:end . 286) (:start . 282)\n  (:id . 82))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 291) (:start . 287)\n  (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 294) (:start . 292)\n  (:id . 84))\n ((:tag . "NN") (:stem . "sigd") (:form . "sIgD") (:end . 299) (:start . 295)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 300) (:start . 299)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x314.4.1) (:span 239 249)))\n (:hscopes ((:id . :x314.4.1) (:span 239 299)))\n (:identifiers (:sid . :s314.4) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002881@unknown@formal@none@1@S@Egr-1 mRNA expression induced by sIgM- and sIgD-crosslinking was inhibited by H7, erbstatin and genistein, but not by HA1004.@(((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sigm-") (:form . "sIgM-") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sigd-crosslinking") (:form . "sIgD-crosslinking")\n  (:end . 60) (:start . 43) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "H7") (:form . "H7") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "erbstatin") (:form . "erbstatin") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ha1004") (:form . "HA1004") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x314.5.1) (:span 111 114)))\n (:nscopes ((:id . :x314.5.1) (:span 111 124)))\n (:identifiers (:sid . :s314.5) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002882@unknown@formal@none@1@S@Erbstatin and genistein inhibited the sIg-crosslinking-induced Egr-1 mRNA expression in a dose-dependent manner parallel to that observed in the inhibition of sIg-crosslinking-induced protein tyrosine phosphorylation.@(((:tag . "NNP") (:stem . "Erbstatin") (:form . "Erbstatin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sig-crosslinking-induced")\n  (:form . "sIg-crosslinking-induced") (:end . 62) (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 68) (:start . 63)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 73) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 104) (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 111)\n  (:start . 105) (:id . 54))\n ((:tag . "JJ") (:stem . "parallel") (:form . "parallel") (:end . 120)\n  (:start . 112) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 137)\n  (:start . 129) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 155)\n  (:start . 145) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sig-crosslinking-induced")\n  (:form . "sIg-crosslinking-induced") (:end . 183) (:start . 159) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 191)\n  (:start . 184) (:id . 64))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 200)\n  (:start . 192) (:id . 65))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 216) (:start . 201) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s314.6) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002883@unknown@formal@none@1@S@Phorbol myristate acetate induced Egr-1 mRNA expression but forskolin and dibutyryl cyclic AMP did not.@(((:tag . "NNP") (:stem . "Phorbol") (:form . "Phorbol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "forskolin") (:form . "forskolin") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "amp") (:form . "AMP") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x314.7.1) (:span 99 102)))\n (:nscopes ((:id . :x314.7.1) (:span 99 102)))\n (:identifiers (:sid . :s314.7) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002884@unknown@formal@none@1@S@These findings suggest that the Egr-1 mRNA activating signals through sIgM and sIgD are protein tyrosine kinase- and PKC-dependent, but protein kinase A-independent.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "sigm") (:form . "sIgM") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sigd") (:form . "sIgD") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "kinase-") (:form . "kinase-") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 150)\n  (:start . 144) (:id . 64))\n ((:tag . "JJ") (:stem . "a-independent") (:form . "A-independent")\n  (:end . 164) (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x314.8.1) (:span 15 22)))\n (:hscopes ((:id . :x314.8.1) (:span 15 164)))\n (:identifiers (:sid . :s314.8) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002885@unknown@formal@none@1@S@Cyclosporin A (CsA) and FK506 rescued B104 cells from death induced by anti-IgM Ab, but did not affect the expression of Egr-1 and c-fos mRNA, showing that CsA and FK506 affect signal transducers differently from or downstream to these molecules.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "b104") (:form . "B104") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-igm") (:form . "anti-IgM") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 102)\n  (:start . 96) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 136)\n  (:start . 131) (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 141) (:start . 137)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 150)\n  (:start . 143) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 159) (:start . 156)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 169)\n  (:start . 164) (:id . 75))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 176)\n  (:start . 170) (:id . 76))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 183)\n  (:start . 177) (:id . 77))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 195)\n  (:start . 184) (:id . 78))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 207)\n  (:start . 196) (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 212) (:start . 208)\n  (:id . 80))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 215) (:start . 213)\n  (:id . 81))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 226)\n  (:start . 216) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 229) (:start . 227)\n  (:id . 83))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 235)\n  (:start . 230) (:id . 84))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 245)\n  (:start . 236) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x314.9.1) (:span 213 215)))\n (:ncues ((:id . :x314.9.2) (:span 92 95)))\n (:hscopes ((:id . :x314.9.1) (:span 196 245)))\n (:nscopes ((:id . :x314.9.2) (:span 92 141)))\n (:identifiers (:sid . :s314.9) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002886@unknown@formal@none@1@S@The difference in signals transduced through sIgM and sIgD in B104 cells is discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "sigm") (:form . "sIgM") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sigd") (:form . "sIgD") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b104") (:form . "B104") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s314.10) (:did . :|94134077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002887@unknown@formal@none@1@S@G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes.@(((:tag . "NNP") (:stem . "G(Anh)MTetra") (:form . "G(Anh)MTetra") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "breakdown") (:form . "breakdown") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 84) (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 137)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s315.1) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002888@unknown@formal@none@1@S@A study of the molecular mechanisms involved in inflammatory cytokine expression [published erratum appears in J Biol Chem 1994 Jun 17;269 ( 24 ):16983]@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Biol") (:form . "Biol") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Chem") (:form . "Chem") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1994") (:form . "1994") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "CD") (:stem . "17;269") (:form . "17;269") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "CD") (:stem . "):16983") (:form . "):16983") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s315.2) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002890@unknown@formal@none@1@S@However, most attention has been focused on lipopolysaccharide (LPS).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "attention") (:form . "attention") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 62) (:start . 44) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s315.4) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002891@unknown@formal@none@1@S@We studied the ability of N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-L-alanyl-D-isoglutamyl-m-diaminopimelyl-D-alanine (G(Anh)MTetra), a naturally occurring breakdown product of peptidoglycan that is produced by soluble lytic transglycosylase of Escherichia coli, to induce cytokine expression in human monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP")\n  (:stem\n   . "N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-L-alanyl-D-isoglutamyl-m-diaminopimelyl-D-alanine")\n  (:form\n   . "N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-L-alanyl-D-isoglutamyl-m-diaminopimelyl-D-alanine")\n  (:end . 124) (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "G(Anh)MTetra)") (:form . "G(Anh)MTetra)")\n  (:end . 139) (:start . 126) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 51))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 152)\n  (:start . 143) (:id . 52))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 162)\n  (:start . 153) (:id . 53))\n ((:tag . "NN") (:stem . "breakdown") (:form . "breakdown") (:end . 172)\n  (:start . 163) (:id . 54))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 180)\n  (:start . 173) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 56))\n ((:tag . "NN") (:stem . "peptidoglycan") (:form . "peptidoglycan")\n  (:end . 197) (:start . 184) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 202) (:start . 198)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 205) (:start . 203)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 214)\n  (:start . 206) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 217) (:start . 215)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 225)\n  (:start . 218) (:id . 62))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 231)\n  (:start . 226) (:id . 63))\n ((:tag . "NN") (:stem . "transglycosylase") (:form . "transglycosylase")\n  (:end . 248) (:start . 232) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 251) (:start . 249)\n  (:id . 65))\n ((:tag . "FW") (:stem . "escherichia") (:form . "Escherichia") (:end . 263)\n  (:start . 252) (:id . 66))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 268) (:start . 264)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 269) (:start . 268)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 272) (:start . 270)\n  (:id . 69))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 279)\n  (:start . 273) (:id . 70))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 288)\n  (:start . 280) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 299)\n  (:start . 289) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 302) (:start . 300)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 308)\n  (:start . 303) (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 318)\n  (:start . 309) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 319) (:start . 318)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s315.5) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002892@unknown@formal@none@1@S@G(Anh)MTetra was found to strongly induce interleukin ( IL ) -1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation.@(((:tag . "NNP") (:stem . "G(Anh)MTetra") (:form . "G(Anh)MTetra") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-1") (:form . "-1") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 144)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 155) (:start . 154)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 169)\n  (:start . 159) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s315.6) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002893@unknown@formal@none@1@S@The increase in mRNA accumulation was at least partly due to an increase in the transcription rates of the respective genes and was accompanied by a strong induction of nuclear factor-kappa B and activator protein-1 transcription factor expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 57))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 143)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 176)\n  (:start . 169) (:id . 71))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 189)\n  (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 191) (:start . 190)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 205)\n  (:start . 196) (:id . 75))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 215)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 229) (:start . 216) (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 236)\n  (:start . 230) (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 247)\n  (:start . 237) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s315.7) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002894@unknown@formal@none@1@S@Experiments using inhibitors of protein kinase C, protein kinase A, and tyrosine kinase-dependent pathways revealed that G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression involves activation of an H7-inhibitable pathway.@(((:tag . "NNS") (:stem . "experiment") (:form . "Experiments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "JJ") (:stem . "kinase-dependent") (:form . "kinase-dependent")\n  (:end . 97) (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "G(Anh)MTetra-induced")\n  (:form . "G(Anh)MTetra-induced") (:end . 141) (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 176)\n  (:start . 166) (:id . 66))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 185)\n  (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 196)\n  (:start . 186) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 202) (:start . 200)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "h7-inhibitable") (:form . "H7-inhibitable")\n  (:end . 217) (:start . 203) (:id . 71))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 225)\n  (:start . 218) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s315.8) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002895@unknown@formal@none@1@S@By using the protein synthesis inhibitor cycloheximide, it was shown that G(Anh)MTetra-induced IL-6 mRNA expression depends on the synthesis of new protein, whereas G(Anh)MTetra-induced IL-1 beta mRNA accumulation does not.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "G(Anh)MTetra-induced")\n  (:form . "G(Anh)MTetra-induced") (:end . 94) (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "VBN") (:stem . "G(Anh)MTetra-induced")\n  (:form . "G(Anh)MTetra-induced") (:end . 185) (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 190) (:start . 186)\n  (:id . 68))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 195) (:start . 191)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 213)\n  (:start . 201) (:id . 71))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 218) (:start . 214)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x315.9.1) (:span 219 222)))\n (:nscopes ((:id . :x315.9.1) (:span 219 222)))\n (:identifiers (:sid . :s315.9) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002896@unknown@formal@none@1@S@When responses to G(Anh)MTetra were compared with those to LPS and muramyldipeptide (MDP), it was found that the optimal response to G(Anh)MTetra induction was similar to that of LPS but significantly higher than the response to MDP.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "G(Anh)MTetra") (:form . "G(Anh)MTetra") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "muramyldipeptide") (:form . "muramyldipeptide")\n  (:end . 83) (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MDP") (:form . "MDP") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "G(Anh)MTetra") (:form . "G(Anh)MTetra")\n  (:end . 145) (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 155)\n  (:start . 146) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 167)\n  (:start . 160) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 182) (:start . 179)\n  (:id . 73))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 200) (:start . 187) (:id . 75))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 212) (:start . 208)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 78))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 225)\n  (:start . 217) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 228) (:start . 226)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "MDP") (:form . "MDP") (:end . 232) (:start . 229)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s315.10) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002897@unknown@formal@none@1@S@Furthermore, maximal G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression could be enhanced by co-stimulation with LPS or MDP, suggesting that different receptors and/or transduction pathways were involved.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "G(Anh)MTetra-induced")\n  (:form . "G(Anh)MTetra-induced") (:end . 41) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 46) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "co-stimulation") (:form . "co-stimulation")\n  (:end . 112) (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MDP") (:form . "MDP") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 165)\n  (:start . 156) (:id . 65))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 172)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 185)\n  (:start . 173) (:id . 67))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 194)\n  (:start . 186) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 199) (:start . 195)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 208)\n  (:start . 200) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x315.11.1) (:span 166 172))\n  ((:id . :x315.11.2) (:span 130 140)) ((:id . :x315.11.3) (:span 77 82)))\n (:hscopes ((:id . :x315.11.1) (:span 146 194))\n  ((:id . :x315.11.2) (:span 130 208)) ((:id . :x315.11.3) (:span 13 208)))\n (:identifiers (:sid . :s315.11) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002898@unknown@formal@none@1@S@These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "G(Anh)MTetra") (:form . "G(Anh)MTetra") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "G(Anh)MTetra") (:form . "G(Anh)MTetra")\n  (:end . 141) (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 176)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 183)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x315.12.1) (:span 111 119))\n  ((:id . :x315.12.2) (:span 98 108)) ((:id . :x315.12.3) (:span 14 27)))\n (:hscopes ((:id . :x315.12.1) (:span 111 183))\n  ((:id . :x315.12.2) (:span 98 183)) ((:id . :x315.12.3) (:span 14 97)))\n (:identifiers (:sid . :s315.12) (:did . :|94140841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002900@unknown@formal@none@1@S@Intron-exon organization and functional analysis of 5'-flanking region.@(((:tag . "JJ") (:stem . "intron-exon") (:form . "Intron-exon") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "organization") (:form . "organization") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 70)\n  (:start . 64) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s316.2) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002901@unknown@formal@none@1@S@Interferon regulatory factor 2 (IRF-2) is a transcriptional regulatory protein that terminates interferon beta expression initiated by interferon regulatory factor 1.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferon") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 59) (:start . 44) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "terminate") (:form . "terminates") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 145)\n  (:start . 135) (:id . 61))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 156)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s316.3) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002902@unknown@formal@none@1@S@In this study, we isolated the genomic DNA for human IRF-2 gene, determined the intron-exon structure of the human IRF-2 gene, mapped the major transcription initiation site, identified a number of potential regulatory elements in the 5'-flanking region, and localized the IRF-2 gene on human chromosome 4.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . 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"elements") (:end . 227)\n  (:start . 219) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 246)\n  (:start . 235) (:id . 82))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 253)\n  (:start . 247) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 254) (:start . 253)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 258) (:start . 255)\n  (:id . 85))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 268)\n  (:start . 259) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 272) (:start . 269)\n  (:id . 87))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 278)\n  (:start . 273) (:id . 88))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 283) (:start . 279)\n  (:id . 89))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 286) (:start . 284)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 292)\n  (:start . 287) (:id . 91))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 303)\n  (:start . 293) (:id . 92))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 305) (:start . 304)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s316.4) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002903@unknown@formal@none@1@S@The IRF-2 promoter region contains a CpG island, with several GC boxes, a putative NF-kappa B-binding site, and a CAAT box, but no TATA box.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CpG") (:form . "CpG") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CAAT") (:form . "CAAT") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 67))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 130) (:start . 128)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 135) (:start . 131)\n  (:id . 69))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 139) (:start . 136)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x316.5.2) (:span 74 82)))\n (:ncues ((:id . :x316.5.1) (:span 128 130)))\n (:hscopes ((:id . :x316.5.2) (:span 74 106)))\n (:nscopes ((:id . :x316.5.1) (:span 128 139)))\n (:identifiers (:sid . :s316.5) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002904@unknown@formal@none@1@S@When the promoter region was linked with a heterologous reporter gene, we found that the promoter region is inducible by both interferons (interferon-alpha and -gamma) and interferon regulatory factor 1.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 55)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 137)\n  (:start . 126) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interferon-alpha") (:form . "interferon-alpha")\n  (:end . 155) (:start . 139) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "-gamma") (:form . "-gamma") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 182)\n  (:start . 172) (:id . 71))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 193)\n  (:start . 183) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s316.6) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002905@unknown@formal@none@1@S@The region which induced these inductions was identified as being confined to 40 nucleotides 5' to the major transcriptional initiation site by testing a series of clones with truncated promoter of IRF-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "induction") (:form . "inductions") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "confine") (:form . "confined") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 124) (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "test") (:form . "testing") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 160)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 175) (:start . 171)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 185)\n  (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s316.7) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002906@unknown@formal@none@1@S@This region contains elements which are shared with the transcriptional enhancers of other genes including interferon regulatory factor 1, interferon beta, and interferon-inducible genes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 71) (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 128)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 137) (:start . 136)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 149)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "interferon-inducible")\n  (:form . "interferon-inducible") (:end . 180) (:start . 160) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 186)\n  (:start . 181) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s316.8) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002907@unknown@formal@none@1@S@These data suggest that interferon regulatory factor 1 not only triggers the activation of the interferon signal transduction pathway, but also may play a role in limiting the duration of this response by activating the transcription of IRF-2.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 125)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 143) (:start . 139)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "duration") (:form . "duration") (:end . 184)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 201)\n  (:start . 193) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 204) (:start . 202)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 215)\n  (:start . 205) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 233) (:start . 220) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 79))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 242)\n  (:start . 237) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x316.9.1) (:span 144 147))\n  ((:id . :x316.9.2) (:span 11 18)))\n (:hscopes ((:id . :x316.9.1) (:span 144 242))\n  ((:id . :x316.9.2) (:span 11 242)))\n (:identifiers (:sid . :s316.9) (:did . :|94148994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002908@unknown@formal@none@1@S@rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils.@(((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 38) (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 48)\n  (:start . 39) (:id . 46))\n ((:tag . "JJ") (:stem . "granulocyte-colony") (:form . "granulocyte-colony")\n  (:end . 67) (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 79)\n  (:start . 68) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 86)\n  (:start . 80) (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 96)\n  (:start . 87) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 52))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 117)\n  (:start . 106) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s317.1) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002910@unknown@formal@none@1@S@The effects of G-CSF are mediated by binding to specific, high affinity receptors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s317.3) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002911@unknown@formal@none@1@S@G-CSF receptors lack intrinsic tyrosine kinase activity, but activation of the receptor results in the rapid induction of tyrosine kinase activity.@(((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 146)\n  (:start . 138) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x317.4.1) (:span 16 20)))\n (:nscopes ((:id . :x317.4.1) (:span 16 55)))\n (:identifiers (:sid . :s317.4) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002912@unknown@formal@none@1@S@Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa.@(((:tag . "NNP") (:stem . "Antiphosphotyrosine")\n  (:form . "Antiphosphotyrosine") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "immunoblot") (:form . "immunoblots") (:end . 31)\n  (:start . 20) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 40) (:start . 35)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 79)\n  (:start . 68) (:id . 50))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 115)\n  (:start . 108) (:id . 56))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 134)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 150) (:start . 135) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 177)\n  (:start . 169) (:id . 65))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 187)\n  (:start . 178) (:id . 66))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 192) (:start . 188)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 68))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 202) (:start . 199)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s317.5) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002913@unknown@formal@none@1@S@Using monospecific antibodies, the 80-kDa tyrosine-phosphorylated protein has been shown to be p80c-rel, a proto-oncogene belonging to a family of transcriptional regulators which include NF-kB.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monospecific") (:form . "monospecific") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "80-kda") (:form . "80-kDa") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 65) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 88) (:start . 83)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 121) (:start . 107) (:id . 58))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 162) (:start . 147) (:id . 64))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 179)\n  (:start . 174) (:id . 66))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 187)\n  (:start . 180) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 193)\n  (:start . 188) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s317.6) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002914@unknown@formal@none@1@S@The induction of tyrosine phosphorylation of p80c-rel was unique to G-CSF in that granulocyte-macrophage colony stimulating factor which also stimulates neutrophils and induces tyrosine phosphorylation does not result in tyrosine phosphorylation of p80c-rel.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 104) (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 123)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 152)\n  (:start . 142) (:id . 61))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 164)\n  (:start . 153) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 176)\n  (:start . 169) (:id . 64))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 185)\n  (:start . 177) (:id . 65))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 201) (:start . 186) (:id . 66))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 206) (:start . 202)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 210) (:start . 207)\n  (:id . 68))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 217)\n  (:start . 211) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 229)\n  (:start . 221) (:id . 71))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 245) (:start . 230) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 73))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 257)\n  (:start . 249) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x317.7.1) (:span 207 210)))\n (:nscopes ((:id . :x317.7.1) (:span 207 257)))\n (:identifiers (:sid . :s317.7) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002915@unknown@formal@none@1@S@The consequences of p80c-rel tyrosine phosphorylation are not yet known;@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 53) (:start . 38) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x317.8.1) (:span 58 61)))\n (:nscopes ((:id . :x317.8.1) (:span 0 71)))\n (:identifiers (:sid . :s317.8) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002916@unknown@formal@none@1@S@however, tyrosine-phosphorylated p80c-rel is capable of binding to DNA, and G-CSF stimulation results in an increase in the amount of p80c-rel which binds to DNA.@(((:tag . "RB") (:stem . "however") (:form . "however") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 32) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s317.9) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002917@unknown@formal@none@1@S@These results demonstrate that one of the first biochemical events which occurs in neutrophils following G-CSF stimulation, activation of a tyrosine kinase, leads directly to the tyrosine phosphorylation of p80c-rel.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 122)\n  (:start . 111) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 203) (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p80c-rel") (:form . "p80c-rel") (:end . 215)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s317.10) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002918@unknown@formal@none@1@S@Thus, the tyrosine kinase activated by G-CSF appears to directly transduce a signal to a protein which functions as a transcriptional regulator.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 59))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 133) (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x317.11.1) (:span 45 52)))\n (:hscopes ((:id . :x317.11.1) (:span 6 143)))\n (:identifiers (:sid . :s317.11) (:did . :|94149008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002920@unknown@formal@none@1@S@RelA (p65) functions as the critical transactivating component of the heterodimeric p50-p65 NF-kappa B complex and contains a high-affinity binding site for its cytoplasmic inhibitor, I kappa B alpha.@(((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 20)\n  (:start . 11) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 52) (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 172)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 182)\n  (:start . 173) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 199)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s318.2) (:did . :|94151327|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002921@unknown@formal@none@1@S@After cellular activation, I kappa B alpha is rapidly degraded in concert with the induced nuclear translocation of NF-kappa B.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 112) (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s318.3) (:did . :|94151327|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002922@unknown@formal@none@1@S@The present study demonstrates that tumor necrosis factor alpha-induced degradation of I kappa B alpha in human T cells is preceded by its rapid phosphorylation in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "alpha-induced") (:form . "alpha-induced")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 83)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "precede") (:form . "preceded") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 160) (:start . 145) (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s318.4) (:did . :|94151327|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002923@unknown@formal@none@1@S@However, these effects on I kappa B alpha result in nuclear mobilization of only a fraction of the entire cytoplasmic pool of RelA.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 72)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 105)\n  (:start . 99) (:id . 61))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 117)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "pool") (:form . "pool") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s318.5) (:did . :|94151327|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002924@unknown@formal@none@1@S@Subsequent studies have revealed that ( i ) cytoplasmic RelA is stably associated not only with I kappa B alpha but also with other ankyrin motif-rich proteins including the products of the NF-kappa B2 (p100) and NF-kappa B1 (p105) genes; ( ii ) in contrast to RelA-I kappa B alpha, RelA-p100 cytoplasmic complexes are not dissociated following tumor necrosis factor alpha activation; ( iii ) p100 functions as a potent inhibitor of RelA-mediated transcription in vivo; ( iv ) the interaction of RelA and p100 involves the conserved Rel homology domain of both proteins but not the nuclear localization signal of RelA, which is required for I kappa B alpha binding; ( v ) p100 inhibition of RelA function requires the C-terminal ankyrin motif domain, which mediates cytoplasmic retention of RelA; and ( vi ) as observed with I kappa B alpha, nuclear RelA stimulates p100 mRNA and protein expression.@(((:tag . "JJ") (:stem . "subsequent") (:form . 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5002925@unknown@formal@none@1@S@These findings thus reveal the presence of a second inducible autoregulated inhibitory pathway that helps ensure the rapid but transient action of nuclear NF-kappa B.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "autoregulated") (:form . "autoregulated")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "help") (:form . "helps") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s318.7) (:did . :|94151327|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002926@unknown@formal@none@1@S@Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.@(((:tag . "NNP") (:stem . "Calcineurin") (:form . "Calcineurin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "inactivate") (:form . "inactivate") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b/mad3") (:form . "B/MAD3") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s319.1) (:did . :|94155850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002927@unknown@formal@none@1@S@The interleukin-2 (IL-2) promoter consists of several independent T cell receptor (TcR) responsive elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s319.2) (:did . :|94155850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002928@unknown@formal@none@1@S@The induction of promoters dependent on these elements is inhibitable by the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK-506).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inhibitable") (:form . "inhibitable") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 95) (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 107)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tacrolimus") (:form . "tacrolimus") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "FK-506") (:form . "FK-506") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s319.3) (:did . :|94155850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002930@unknown@formal@none@1@S@We report that a constitutively active form of calcineurin partially substitutes for the Ca2+ co-stimulus required to activate the IL-2 promoter elements IL-2A (which binds the factors OAP and Oct-1) and IL-2E (which binds NF-AT), and completely substitutes for the Ca2+ co-stimulus required to stimulate an NF-kappa B-dependent element.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 31) (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "form") (:form . 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5002931@unknown@formal@none@1@S@Calcineurin stimulates the NF-kappa B element by enhancing inactivation of I kappa B/MAD3, an inhibitor of NF-kappa B, thereby increasing the amount of nuclear NF-kappa B DNA binding activity.@(((:tag . "NNP") (:stem . "Calcineurin") (:form . "Calcineurin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "b/mad3") (:form . "B/MAD3") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 148)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 191)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s319.6) (:did . :|94155850|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002932@unknown@formal@none@1@S@These data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate I kappa B, and suggest one possible explanation for mechanism-based toxicities associated with FK-506 and CsA by demonstrating that these drugs can inhibit the calcineurin-dependent activation of a virtually ubiquitous transcription factor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . 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5002933@unknown@formal@none@1@S@Direct exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases infectivity of human erythrocytes to a malarial parasite.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "2,3,7,8-tetrachlorodibenzo-p-dioxin")\n  (:form . "2,3,7,8-tetrachlorodibenzo-p-dioxin") (:end . 54) (:start . 19)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 60) (:start . 56)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 71)\n  (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "infectivity") (:form . "infectivity") (:end . 83)\n  (:start . 72) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 105)\n  (:start . 93) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "malarial") (:form . "malarial") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "parasite") (:form . "parasite") (:end . 128)\n  (:start . 120) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s320.1) (:did . :|94166578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002934@unknown@formal@none@1@S@Direct exposure to 10 nM 2,3,7,8-TCDD caused a 75 % increase and a 2-fold increase in the infectivity of isolated human erythrocytes to P. falciparum after 48 hours when the parasites were in an unsynchronized or synchronized state of growth, respectively.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "2,3,7,8-TCDD") (:form . "2,3,7,8-TCDD") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "2-fold") (:form . "2-fold") (:end . 73)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "infectivity") (:form . "infectivity") (:end . 101)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 132)\n  (:start . 120) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "P.") (:form . "P.") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "falciparum") (:form . "falciparum") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "parasite") (:form . "parasites") (:end . 183)\n  (:start . 174) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 188) (:start . 184)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 194) (:start . 192)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "unsynchronized") (:form . "unsynchronized")\n  (:end . 209) (:start . 195) (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 212) (:start . 210)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "synchronize") (:form . "synchronized") (:end . 225)\n  (:start . 213) (:id . 78))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 231)\n  (:start . 226) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 241)\n  (:start . 235) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 242) (:start . 241)\n  (:id . 82))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 255)\n  (:start . 243) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s320.2) (:did . :|94166578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002935@unknown@formal@none@1@S@Treatment of human erythrocytes with 10 microM sodium orthovanadate (NaOV), an inhibitor of plasma membrane Ca-ATPase and phosphotyrosine phosphatase, decreased parasitemia by 30 %.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "orthovanadate") (:form . "orthovanadate")\n  (:end . 67) (:start . 54) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NaOV") (:form . "NaOV") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "ca-atpase") (:form . "Ca-ATPase") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phosphotyrosine") (:form . "phosphotyrosine")\n  (:end . 137) (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 149)\n  (:start . 138) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "parasitemia") (:form . "parasitemia") (:end . 172)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s320.3) (:did . :|94166578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002936@unknown@formal@none@1@S@Co-treatment of RBCs with TCDD and NaOV completely blocked the TCDD-induced increase in parasitemia.@(((:tag . "NNP") (:stem . "Co-treatment") (:form . "Co-treatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "RBC") (:form . "RBCs") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NaOV") (:form . "NaOV") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tcdd-induced") (:form . "TCDD-induced") (:end . 75)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "parasitemia") (:form . "parasitemia") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s320.4) (:did . :|94166578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002937@unknown@formal@none@1@S@Because erythrocytes are anucleated, these results are discussed as evidence for biochemical changes by TCDD without requiring the activation of gene products.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "anucleate") (:form . "anucleated") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x320.5.1) (:span 109 116)))\n (:nscopes ((:id . :x320.5.1) (:span 109 158)))\n (:identifiers (:sid . :s320.5) (:did . :|94166578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002938@unknown@formal@none@1@S@Comparative mapping of SRY in the great apes.@(((:tag . "JJ") (:stem . "comparative") (:form . "Comparative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "ape") (:form . "apes") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s321.1) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002940@unknown@formal@none@1@S@We have used in situ hybridization to define these rearrangements at the molecular level.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 65) (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s321.3) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002941@unknown@formal@none@1@S@pHU-14, a probe including sequences from the sex determining gene SRY, hybridizes close to the early replicating pseudoautosomal segment in a telomeric or subtelomeric position of the Y chromosomes of all great apes.@(((:tag . "NN") (:stem . "phu-14") (:form . "pHU-14") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "hybridize") (:form . "hybridizes") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "RB") (:stem . "close") (:form . "close") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "replicate") (:form . "replicating") (:end . 112)\n  (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "pseudoautosomal") (:form . "pseudoautosomal")\n  (:end . 128) (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "telomeric") (:form . "telomeric") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "subtelomeric") (:form . "subtelomeric") (:end . 167)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 197)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 210)\n  (:start . 205) (:id . 75))\n ((:tag . "NNS") (:stem . "ape") (:form . "apes") (:end . 215) (:start . 211)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s321.4) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002942@unknown@formal@none@1@S@The low copy repeat detected by the probe Fr35-II is obviously included in Y chromosomal rearrangements during hominid evolution.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "copy") (:form . "copy") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Fr35-II") (:form . "Fr35-II") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "obviously") (:form . "obviously") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "VBN") (:stem . "include") (:form . "included") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Y") (:form . "Y") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chromosomal") (:form . "chromosomal") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 103) (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "hominid") (:form . "hominid") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s321.5) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002943@unknown@formal@none@1@S@These results, combined with previous studies, suggest that the Y chromosome in great apes has a conserved region including the pseudoautosomal region and the testis-determining region.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "ape") (:form . "apes") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 123)\n  (:start . 114) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "pseudoautosomal") (:form . "pseudoautosomal")\n  (:end . 143) (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "testis-determining") (:form . "testis-determining")\n  (:end . 177) (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 184)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x321.6.1) (:span 47 54)))\n (:hscopes ((:id . :x321.6.1) (:span 47 184)))\n (:identifiers (:sid . :s321.6) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002944@unknown@formal@none@1@S@The rest of the Y chromosome has undergone several rearrangements in the different great apes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rest") (:form . "rest") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Y") (:form . "Y") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 28)\n  (:start . 18) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "undergo") (:form . "undergone") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 65) (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "ape") (:form . "apes") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s321.7) (:did . :|94191916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002945@unknown@formal@none@1@S@Detection of minimal residual disease in a patient with acute promyelocytic leukemia by RT-PCR: necessity of chemotherapy following ATRA therapy.@(((:tag . "NN") (:stem . "detection") (:form . "Detection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "residual") (:form . "residual") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "necessity") (:form . "necessity") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s322.1) (:did . :|94193110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002946@unknown@formal@none@1@S@The PML/RAR alpha fusion gene resulting from the t(15;17) translocation is a specific marker for acute promyelocytic leukemia (APL).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PML/RAR") (:form . "PML/RAR") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "t(15;17)") (:form . "t(15;17)") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s322.2) (:did . :|94193110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002947@unknown@formal@none@1@S@We examined bone marrow cells by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect residual PML/RAR alpha mRNA-containing cells following treatment with all-trans retinoic acid (ATRA) and cytotoxic chemotherapy in a patient with APL.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 65) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "residual") (:form . "residual") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "pml/rar") (:form . "PML/RAR") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "mrna-containing") (:form . "mRNA-containing")\n  (:end . 138) (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 164)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 179)\n  (:start . 170) (:id . 65))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 188)\n  (:start . 180) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 193) (:start . 189)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 199) (:start . 195)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 214)\n  (:start . 205) (:id . 72))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 227)\n  (:start . 215) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 232) (:start . 231)\n  (:id . 75))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 240)\n  (:start . 233) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 245) (:start . 241)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 249) (:start . 246)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s322.3) (:did . :|94193110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002948@unknown@formal@none@1@S@This RT-PCR assay can detect one leukemic cell in 10(2) normal cells in vitro.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 11)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "10(2)") (:form . "10(2)") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s322.4) (:did . :|94193110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002950@unknown@formal@none@1@S@These data show that this technique is useful for the identification of minimal residual disease in patients with APL and that cytotoxic chemotherapy following ATRA therapy is required for the elimination of APL cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 68) (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "residual") (:form . "residual") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 149)\n  (:start . 137) (:id . 64))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 172)\n  (:start . 165) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 204)\n  (:start . 193) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 217)\n  (:start . 212) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s322.6) (:did . :|94193110|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002951@unknown@formal@none@1@S@Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome.@(((:tag . "NNS") (:stem . "gene") (:form . "Genes") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "disperse") (:form . "dispersed") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s323.1) (:did . :|94214477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002952@unknown@formal@none@1@S@General transcription factors are required for accurate initiation of transcription by RNA polymerase II.@(((:tag . "JJ") (:stem . "general") (:form . "General") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s323.2) (:did . :|94214477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002953@unknown@formal@none@1@S@Human cDNAs encoding subunits of these factors have been cloned and sequenced.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s323.3) (:did . :|94214477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002954@unknown@formal@none@1@S@Using fluorescence in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIE alpha, TFIIE beta, RAP30, RAP74 and the 62 kDa subunit, of TFIIH are located at the human chromosomal bands 6q26-27, 1p21-22, 3q21-24, 8p12, 13q14, 19p13.3 and 11p14-15.1, respectively.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fish") (:form . "FISH") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 85)\n  (:start . 77) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tata-box") (:form . "TATA-box") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TFIIB") (:form . "TFIIB") (:end . 127)\n  (:start . 122) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TFIIE") (:form . "TFIIE") (:end . 134)\n  (:start . 129) (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . 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"kda") (:form . "kDa") (:end . 181) (:start . 178)\n  (:id . 80))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 189)\n  (:start . 182) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 83))\n ((:tag . "NN") (:stem . "tfiih") (:form . "TFIIH") (:end . 199)\n  (:start . 194) (:id . 84))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 203) (:start . 200)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 211)\n  (:start . 204) (:id . 86))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 214) (:start . 212)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 224)\n  (:start . 219) (:id . 89))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 236)\n  (:start . 225) (:id . 90))\n ((:tag . "NNS") (:stem . "band") (:form . "bands") (:end . 242)\n  (:start . 237) (:id . 91))\n ((:tag . "NN") (:stem . "6q26-27") (:form . "6q26-27") (:end . 250)\n  (:start . 243) (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 251) (:start . 250)\n  (:id . 93))\n ((:tag . "NN") (:stem . "1p21-22") (:form . "1p21-22") (:end . 259)\n  (:start . 252) (:id . 94))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 260) (:start . 259)\n  (:id . 95))\n ((:tag . "NN") (:stem . "3q21-24") (:form . "3q21-24") (:end . 268)\n  (:start . 261) (:id . 96))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 269) (:start . 268)\n  (:id . 97))\n ((:tag . "NN") (:stem . "8p12") (:form . "8p12") (:end . 274) (:start . 270)\n  (:id . 98))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 275) (:start . 274)\n  (:id . 99))\n ((:tag . "NN") (:stem . "13q14") (:form . "13q14") (:end . 281)\n  (:start . 276) (:id . 100))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 282) (:start . 281)\n  (:id . 101))\n ((:tag . "NN") (:stem . "19p13.3") (:form . "19p13.3") (:end . 290)\n  (:start . 283) (:id . 102))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 294) (:start . 291)\n  (:id . 103))\n ((:tag . "NN") (:stem . "11p14-15.1") (:form . "11p14-15.1") (:end . 305)\n  (:start . 295) (:id . 104))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 306) (:start . 305)\n  (:id . 105))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 319)\n  (:start . 307) (:id . 106))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 320) (:start . 319)\n  (:id . 107)))@@@1@66@((:identifiers (:sid . :s323.4) (:did . :|94214477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002955@unknown@formal@none@1@S@This dispersed localization of a group of functionally related gene provides insights into the molecular mechanism of human genome evolution and their possible involvement in human diseases.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dispersed") (:form . "dispersed") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 171)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 189)\n  (:start . 181) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x323.5.1) (:span 151 159)))\n (:hscopes ((:id . :x323.5.1) (:span 151 189)))\n (:identifiers (:sid . :s323.5) (:did . :|94214477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002956@unknown@formal@none@1@S@Patterns of Pan expression and role of Pan proteins in endocrine cell type-specific complex formation.@(((:tag . "NNS") (:stem . "pattern") (:form . "Patterns") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s324.1) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002957@unknown@formal@none@1@S@The Pan gene encodes at least two distinct transcripts, Pan-1 and Pan-2 (also known as E47 and E12, respectively) , by the mechanism of alternative RNA splicing.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pan-1") (:form . "Pan-1") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pan-2") (:form . "Pan-2") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "E12") (:form . "E12") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 62))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 112)\n  (:start . 100) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 132)\n  (:start . 123) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 147)\n  (:start . 136) (:id . 70))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 151) (:start . 148)\n  (:id . 71))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 160)\n  (:start . 152) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s324.2) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002958@unknown@formal@none@1@S@Northern blot analyses performed on rat and mouse tissues have detected ubiquitously expressed Pan transcripts, but the abundance, distribution, and form of Pan proteins have not been clearly defined.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 143)\n  (:start . 131) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 199)\n  (:start . 192) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x324.3.1) (:span 175 178)))\n (:nscopes ((:id . :x324.3.1) (:span 116 199)))\n (:identifiers (:sid . :s324.3) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002960@unknown@formal@none@1@S@We have developed a monoclonal antibody, Yae, which is specific for Pan/E2A proteins, and have used the Yae antibody to examine a variety of endocrine and nonendocrine cell lineages for differences in Pan/E2A protein expression, subcellular localization, and heteromeric complex formation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Yae") (:form . "Yae") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Pan/E2A") (:form . "Pan/E2A") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "yae") (:form . "Yae") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 116)\n  (:start . 108) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 127)\n  (:start . 120) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 137)\n  (:start . 130) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 150)\n  (:start . 141) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nonendocrine") (:form . "nonendocrine") (:end . 167)\n  (:start . 155) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 181)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 185) (:start . 182)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 197)\n  (:start . 186) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Pan/E2A") (:form . "Pan/E2A") (:end . 208)\n  (:start . 201) (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 216)\n  (:start . 209) (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 227)\n  (:start . 217) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 240)\n  (:start . 229) (:id . 81))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 253)\n  (:start . 241) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 254) (:start . 253)\n  (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 258) (:start . 255)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "heteromeric") (:form . "heteromeric") (:end . 270)\n  (:start . 259) (:id . 85))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 278)\n  (:start . 271) (:id . 86))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 288)\n  (:start . 279) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s324.5) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002961@unknown@formal@none@1@S@In contrast to previous results obtained using polyclonal antiseras to detect Pan/E2A proteins, we report comparable levels of Pan proteins in GH/PRL- and insulin-producing, B- and T-lymphocyte cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "antisera") (:form . "antiseras") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "Pan/E2A") (:form . "Pan/E2A") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 123)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gh/prl-") (:form . "GH/PRL-") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "insulin-producing") (:form . "insulin-producing")\n  (:end . 172) (:start . 155) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "b-") (:form . "B-") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t-lymphocyte") (:form . "T-lymphocyte") (:end . 193)\n  (:start . 181) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s324.6) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002962@unknown@formal@none@1@S@IEF-1, a pancreatic beta-cell type-specific complex believed to regulate insulin expression, is demonstrated to consist of at least two distinct species, one of which does not contain Pan molecules.@(((:tag . "NNP") (:stem . "IEF-1") (:form . "IEF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "beta-cell") (:form . "beta-cell") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "VB") (:stem . "consist") (:form . "consist") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 166)\n  (:start . 161) (:id . 68))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x324.7.1) (:span 172 175)))\n (:nscopes ((:id . :x324.7.1) (:span 172 197)))\n (:identifiers (:sid . :s324.7) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002963@unknown@formal@none@1@S@Although it has been postulated that pituitary endocrine cells and pancreatic endocrine beta-cells share identical Pan/E2A complexes, native-Western analyses of pituitary and endocrine beta-cells detect Pan proteins in distinct cell type-specific complexes.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "postulate") (:form . "postulated") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "beta-cell") (:form . "beta-cells") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 104)\n  (:start . 99) (:id . 55))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "NNP") (:stem . "Pan/E2A") (:form . "Pan/E2A") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 132)\n  (:start . 123) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "native-western") (:form . "native-Western")\n  (:end . 148) (:start . 134) (:id . 60))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 157)\n  (:start . 149) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 170)\n  (:start . 161) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 184)\n  (:start . 175) (:id . 65))\n ((:tag . "NNS") (:stem . "beta-cell") (:form . "beta-cells") (:end . 195)\n  (:start . 185) (:id . 66))\n ((:tag . "VBP") (:stem . "detect") (:form . "detect") (:end . 202)\n  (:start . 196) (:id . 67))\n ((:tag . "NNP") (:stem . "Pan") (:form . "Pan") (:end . 206) (:start . 203)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 215)\n  (:start . 207) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 227)\n  (:start . 219) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 232) (:start . 228)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 246) (:start . 233) (:id . 73))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 256)\n  (:start . 247) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x324.8.1) (:span 21 31)))\n (:hscopes ((:id . :x324.8.1) (:span 21 132)))\n (:identifiers (:sid . :s324.8) (:did . :|94224239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002964@unknown@formal@none@1@S@Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferon") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 97) (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 105)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 113) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 142)\n  (:start . 133) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 167)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 175)\n  (:start . 168) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x325.1.1) (:span 147 150)))\n (:nscopes ((:id . :x325.1.1) (:span 147 175)))\n (:identifiers (:sid . :s325.1) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002965@unknown@formal@none@1@S@The human myeloid cell nuclear differentiation antigen (MNDA) is expressed constitutively in cells of the myeloid lineage, appearing in myeloblast cells in some cases of acute myeloid leukemia and consistently being detected in promyelocyte stage cells as well as in all later stage cells including peripheral blood monocytes and granulocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . 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"cells") (:end . 288)\n  (:start . 283) (:id . 88))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 298)\n  (:start . 289) (:id . 89))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 309)\n  (:start . 299) (:id . 90))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 315)\n  (:start . 310) (:id . 91))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 325)\n  (:start . 316) (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 329) (:start . 326)\n  (:id . 93))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 342)\n  (:start . 330) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 343) (:start . 342)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s325.2) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002966@unknown@formal@none@1@S@The human myeloid leukemia cell lines, HL-60, U937, and THP-1, express similar levels of immunochemically detectable MNDA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 70)\n  (:start . 63) (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 85)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "RB") (:stem . "immunochemically") (:form . "immunochemically")\n  (:end . 105) (:start . 89) (:id . 60))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s325.3) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002967@unknown@formal@none@1@S@Although , the level of MNDA mRNA in primary monocytes is very low it was up-regulated at 6 h following the addition of interferon alpha.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 86)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 103)\n  (:start . 94) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 116)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 130)\n  (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s325.4) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002968@unknown@formal@none@1@S@The effect of interferon alpha on the MNDA mRNA is also observed in the cell lines HL-60, U937, and THP-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 105)\n  (:start . 100) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s325.5) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002970@unknown@formal@none@1@S@The MNDA mRNA level in the myeloid cell lines was also unaffected by the latter four agents.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s325.7) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002971@unknown@formal@none@1@S@Induction of differentiation in the myeloid cell lines with phorbol ester induces monocyte differentiation which was accompanied by a decrease in MNDA mRNA level.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 28) (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 106) (:start . 91) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 128)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s325.8) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5002973@unknown@formal@none@1@S@The effects of phorbol ester on MNDA mRNA appeared to be associated with induced differentiation since inhibiting cell proliferation did not alter the level of MNDA mRNA and cell cycle variation in MNDA mRNA levels were not observed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 96) (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 132) (:start . 119) (:id . 60))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 156)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 184)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 194)\n  (:start . 185) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 202) (:start . 198)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 207) (:start . 203)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 214)\n  (:start . 208) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 219) (:start . 215)\n  (:id . 77))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 223) (:start . 220)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 232)\n  (:start . 224) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x325.10.3) (:span 42 50)))\n (:ncues ((:id . :x325.10.1) (:span 220 223))\n  ((:id . :x325.10.2) (:span 137 140)))\n (:hscopes ((:id . :x325.10.3) (:span 0 96)))\n (:nscopes ((:id . :x325.10.1) (:span 174 232))\n  ((:id . :x325.10.2) (:span 137 169)))\n (:identifiers (:sid . :s325.10) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002974@unknown@formal@none@1@S@The ability of interferon alpha to up-regulate MNDA mRNA in phorbol ester treated myeloid cell lines is consistent with the observations made in primary monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "up-regulate") (:form . "up-regulate") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "treated") (:form . "treated") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 136)\n  (:start . 124) (:id . 62))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 162)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s325.11) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002975@unknown@formal@none@1@S@(ABSTRACT TRUNCATED AT 250 WORDS)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "abstract") (:form . "ABSTRACT") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "VBN") (:stem . "truncated") (:form . "TRUNCATED") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "AT") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "words") (:form . "WORDS") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s325.12) (:did . :|94230583|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002976@unknown@formal@none@1@S@Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells:@(((:tag . "NNP") (:stem . "Calcineurin") (:form . "Calcineurin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 64) (:start . 42) (:id . 47))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 83) (:start . 65) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 90)\n  (:start . 84) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 95) (:start . 91)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s326.1) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002977@unknown@formal@none@1@S@involvement of the conserved lymphokine element 0.@(((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s326.2) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002978@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) are produced by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 56)\n  (:start . 50) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 75) (:start . 62) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phorbol-12-myristate")\n  (:form . "phorbol-12-myristate") (:end . 136) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 144)\n  (:start . 137) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 172)\n  (:start . 163) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "a23187") (:form . "A23187") (:end . 180)\n  (:start . 174) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 190)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 197) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 206)\n  (:start . 198) (:id . 73))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 213)\n  (:start . 207) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 219)\n  (:start . 214) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s326.3) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002980@unknown@formal@none@1@S@Earlier studies on the IL-2 gene expression showed that overexpression of calcineurin (CN), a Ca2+/calmodulin-dependent protein phosphatase, can stimulate transcription from the IL-2 promoter through the NF-AT-binding site.@(((:tag . "JJR") (:stem . "early") (:form . "Earlier") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 50) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 70) (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 119) (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 154)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 173) (:start . 169)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 182) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 199)\n  (:start . 192) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 217) (:start . 204) (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 222) (:start . 218)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s326.5) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002981@unknown@formal@none@1@S@In this study, we obtained evidence that transfection of the cDNAs for CN A (catalytic) and CN B (regulatory) subunits also augments transcription from the GM-CSF promoter and recovers the transcription inhibited by CsA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "obtain") (:form . "obtained") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 53)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 86)\n  (:start . 77) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 108)\n  (:start . 98) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 118)\n  (:start . 110) (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 123) (:start . 119)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 132)\n  (:start . 124) (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 146) (:start . 133) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 151) (:start . 147)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 162)\n  (:start . 156) (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 171)\n  (:start . 163) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "recover") (:form . "recovers") (:end . 184)\n  (:start . 176) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 202) (:start . 189) (:id . 77))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 212)\n  (:start . 203) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 215) (:start . 213)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s326.6) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002982@unknown@formal@none@1@S@The constitutively active type of the CN A subunit, which lacks the auto-inhibitory and calmodulin-binding domains, acts in synergy with PMA to activate transcription from the GM-CSF promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "auto-inhibitory") (:form . "auto-inhibitory")\n  (:end . 83) (:start . 68) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "calmodulin-binding") (:form . "calmodulin-binding")\n  (:end . 106) (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 166) (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 191)\n  (:start . 183) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x326.7.1) (:span 58 63)))\n (:nscopes ((:id . :x326.7.1) (:span 58 114)))\n (:identifiers (:sid . :s326.7) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002983@unknown@formal@none@1@S@We also found that the active CN partially replaces calcium ionophore in synergy with PMA to induce expression of endogenous GM-CSF and IL-2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "VBZ") (:stem . "replace") (:form . "replaces") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s326.8) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002984@unknown@formal@none@1@S@By multimerizing the regulatory elements of the GM-CSF promoter, we found that one of the target sites for the CN action is the conserved lymphokine element 0 (CLE0), located at positions between -54 and -40.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "multimerize") (:form . "multimerizing") (:end . 16)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 137)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 164) (:start . 160)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 174)\n  (:start . 167) (:id . 74))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 177) (:start . 175)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 187)\n  (:start . 178) (:id . 76))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 195)\n  (:start . 188) (:id . 77))\n ((:tag . "CD") (:stem . "-54") (:form . "-54") (:end . 199) (:start . 196)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 79))\n ((:tag . "CD") (:stem . "-40") (:form . "-40") (:end . 207) (:start . 204)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s326.9) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002985@unknown@formal@none@1@S@Mobility shift assays showed that the CLE0 sequence has an AP1-binding site and is associated with an NF-AT-like factor, termed NF-CLE0 gamma.@(((:tag . "NN") (:stem . "mobility") (:form . "Mobility") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 28) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cle0") (:form . "CLE0") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ap1-binding") (:form . "AP1-binding") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nf-at-like") (:form . "NF-AT-like") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "nf-cle0") (:form . "NF-CLE0") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s326.10) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002986@unknown@formal@none@1@S@NF-CLE0 gamma binding is induced by PMA/A23187 and is inhibited by treatment with CsA.@(((:tag . "NNP") (:stem . "NF-CLE0") (:form . "NF-CLE0") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA/A23187") (:form . "PMA/A23187") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s326.11) (:did . :|94243031|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002987@unknown@formal@none@1@S@These results suggest that CN is involved in the coordinated induction of the GM-CSF and IL-2 genes and that the CLE0 sequence of the GM-CSF gene is a functional analogue of the NF-AT-binding site in the IL-2 promoter, which mediates signals downstream of T cell activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . 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"JJ") (:stem . "functional") (:form . "functional") (:end . 161)\n  (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "analogue") (:form . "analogue") (:end . 170)\n  (:start . 162) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 191) (:start . 178) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 77))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 208) (:start . 204)\n  (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 217)\n  (:start . 209) (:id . 79))\n ((:tag . ",") (:stem . 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5002988@unknown@formal@none@1@S@Novel aldosterone receptors: specificity-conferring mechanism at the level of the cell membrane.@(((:tag . "JJ") (:stem . "novel") (:form . "Novel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specificity-conferring")\n  (:form . "specificity-conferring") (:end . 51) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s327.1) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5002990@unknown@formal@none@1@S@These involve activation of the sodium/proton-exchanger of the cell membrane at very low, physiological concentrations of aldosterone with an acute onset within 1-2 minutes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sodium/proton-exchanger")\n  (:form . "sodium/proton-exchanger") (:end . 55) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 103) (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 118) (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 133)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 160)\n  (:start . 154) (:id . 64))\n ((:tag . "CD") (:stem . "1-2") (:form . "1-2") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s327.3) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002991@unknown@formal@none@1@S@A second messenger cascade involved is the inositol-1,4,5-trisphosphate/calcium pathway which responds over the same rapid time course.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inositol-1,4,5-trisphosphate/calcium")\n  (:form . "inositol-1,4,5-trisphosphate/calcium") (:end . 79) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 87)\n  (:start . 80) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 93) (:start . 88)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 102)\n  (:start . 94) (:id . 52))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 107) (:start . 103)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 116) (:start . 112)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 122)\n  (:start . 117) (:id . 56))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 127) (:start . 123)\n  (:id . 57))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 134)\n  (:start . 128) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s327.4) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002992@unknown@formal@none@1@S@Such changes clearly can not be explained by genomic mechanisms, which are responsible for later effects than the membrane-related rapid responses.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "membrane-related") (:form . "membrane-related")\n  (:end . 130) (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x327.5.1) (:span 21 28)))\n (:nscopes ((:id . :x327.5.1) (:span 0 146)))\n (:identifiers (:sid . :s327.5) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002993@unknown@formal@none@1@S@In addition to its rapid time course the unique characteristics of this new pathway for steroid action include a 10000-fold selectivity for aldosterone over cortisol and the ineffectiveness of spironolactones, classical mineralocorticoid antagonists, as antagonists of the response.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 63) (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "10000-fold") (:form . "10000-fold") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "selectivity") (:form . "selectivity") (:end . 135)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ineffectiveness") (:form . "ineffectiveness")\n  (:end . 189) (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "spironolactone") (:form . "spironolactones")\n  (:end . 208) (:start . 193) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 219)\n  (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 237) (:start . 220) (:id . 74))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 249)\n  (:start . 238) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 250) (:start . 249)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 253) (:start . 251)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 265)\n  (:start . 254) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 268) (:start . 266)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 272) (:start . 269)\n  (:id . 80))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 281)\n  (:start . 273) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s327.6) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002994@unknown@formal@none@1@S@Subsequently binding sites have been demonstrated in the plasma membrane of human lymphocytes which show pharmacological (aldosterone specificity) and kinetic (high turnover) properties identical with those of the rapid aldosterone effects in the same cells.@(((:tag . "RB") (:stem . "subsequently") (:form . "Subsequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 26) (:start . 21)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pharmacological") (:form . "pharmacological")\n  (:end . 120) (:start . 105) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 133)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 145)\n  (:start . 134) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "kinetic") (:form . "kinetic") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 173)\n  (:start . 165) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 185)\n  (:start . 175) (:id . 68))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 195)\n  (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 206)\n  (:start . 201) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 219)\n  (:start . 214) (:id . 74))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 231)\n  (:start . 220) (:id . 75))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 239)\n  (:start . 232) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 242) (:start . 240)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 251) (:start . 247)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 257)\n  (:start . 252) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s327.7) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002995@unknown@formal@none@1@S@SDS-PAGE analysis of the receptor protein has shown a molecular weight of approximately 50 kD.@(((:tag . "NN") (:stem . "sds-page") (:form . "SDS-PAGE") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s327.8) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002996@unknown@formal@none@1@S@The present paper reviews the data supporting a new, two-step model for non-genomic and genomic aldosterone effects.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "review") (:form . "reviews") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "support") (:form . "supporting") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "two-step") (:form . "two-step") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "non-genomic") (:form . "non-genomic") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s327.9) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002997@unknown@formal@none@1@S@It also suggests a novel specificity-conferring mechanism for mineralocorticoid action at the membrane level.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specificity-conferring")\n  (:form . "specificity-conferring") (:end . 47) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 79) (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 86)\n  (:start . 80) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 108)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x327.10.1) (:span 8 16)))\n (:hscopes ((:id . :x327.10.1) (:span 8 108)))\n (:identifiers (:sid . :s327.10) (:did . :|94249033|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5002998@unknown@formal@none@1@S@Glucocorticoid-mediated inhibition of interleukin-2 receptor alpha and -beta subunit expression by human T cells.@(((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "Glucocorticoid-mediated") (:end . 23) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 34)\n  (:start . 24) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 51) (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 60)\n  (:start . 52) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 66) (:start . 61)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 48))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 76) (:start . 71)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 84)\n  (:start . 77) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s328.1) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003000@unknown@formal@none@1@S@Dexamethasone inhibited IL-2-induced T cell proliferation by 30 % - 88 %, relative to its concentration within the cultures.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 36)\n  (:start . 24) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . "88") (:form . "88") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 103) (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s328.3) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003001@unknown@formal@none@1@S@The effect of DM on expression of IL-2R alpha (Tac, p55, CD25) and beta (p75) genes in activated T cells was examined next.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tac") (:form . "Tac") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p55") (:form . "p55") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD25") (:form . "CD25") (:end . 61) (:start . 57)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 71) (:start . 67)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 76) (:start . 73)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 96)\n  (:start . 87) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 117)\n  (:start . 109) (:id . 69))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 122) (:start . 118)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s328.4) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003002@unknown@formal@none@1@S@In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60 % reduction in IL-2R alpha and a 30 % reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . 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5003003@unknown@formal@none@1@S@Inhibition of membrane IL-2R alpha and IL-2R beta expression by 10(-6) M DM was partially reversible by recombinant human IL-2 (rhIL-2).@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "10(-6)") (:form . "10(-6)") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "rhil-2") (:form . "rhIL-2") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s328.6) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003004@unknown@formal@none@1@S@By Northern blot analysis, DM caused a comparable decrease in IL-2R alpha and in IL-2R beta mRNA levels to membrane receptor expression in mitogen-stimulated T cells.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "mitogen-stimulated") (:form . "mitogen-stimulated")\n  (:end . 157) (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s328.7) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003005@unknown@formal@none@1@S@By in vitro transcription assays, DM regulated IL-2R alpha gene expression at a transcriptional level while transcription of IL-2R beta gene was unaffected by DM.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "regulate") (:form . "regulated") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 95) (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 155)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s328.8) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003006@unknown@formal@none@1@S@The mechanism of action of DM on IL-2R alpha transcription was examined by determining the mRNA levels of the p50 subunit of nuclear factor kappa B (NF-kappa B), a transcription factor that stimulates IL-2R alpha gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 139)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 177) (:start . 164) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 184)\n  (:start . 178) (:id . 75))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 189) (:start . 185)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 200)\n  (:start . 190) (:id . 77))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 206)\n  (:start . 201) (:id . 78))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 212)\n  (:start . 207) (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 217) (:start . 213)\n  (:id . 80))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 228)\n  (:start . 218) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s328.9) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003007@unknown@formal@none@1@S@The data indicate that 10(-6) M DM increased T cell p50 NF-kappa B mRNA levels by four-fold compared to the levels obtained in the absence of DM.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "10(-6)") (:form . "10(-6)") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "RB") (:stem . "four-fold") (:form . "four-fold") (:end . 91)\n  (:start . 82) (:id . 58))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 138)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x328.10.1) (:span 9 22)))\n (:hscopes ((:id . :x328.10.1) (:span 9 144)))\n (:identifiers (:sid . :s328.10) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003008@unknown@formal@none@1@S@Further, the level of nuclear proteins capable of binding to the NF-kappa B sites in activated T cells increased in response to DM.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 112)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s328.11) (:did . :|94266606|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003010@unknown@formal@none@1@S@Function and activation of NF-kappa B in the immune system.@(((:tag . "NN") (:stem . "function") (:form . "Function") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s329.1) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003011@unknown@formal@none@1@S@NF-kappa B is a ubiquitous transcription factor.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s329.2) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003012@unknown@formal@none@1@S@Nevertheless, its properties seem to be most extensively exploited in cells of the immune system.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "seem") (:form . "seem") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "exploit") (:form . "exploited") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x329.3.1) (:span 29 33)))\n (:hscopes ((:id . :x329.3.1) (:span 14 96)))\n (:identifiers (:sid . :s329.3) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003013@unknown@formal@none@1@S@Among these properties are NF-kappa B 's rapid posttranslational activation in response to many pathogenic signals, its direct participation in cytoplasmic/nuclear signaling, and its potency to activate transcription of a great variety of genes encoding immunologically relevant proteins.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "posttranslational") (:form . "posttranslational")\n  (:end . 64) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 140) (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytoplasmic/nuclear")\n  (:form . "cytoplasmic/nuclear") (:end . 163) (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 173)\n  (:start . 164) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 190)\n  (:start . 183) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 69))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 202)\n  (:start . 194) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 216) (:start . 203) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 221) (:start . 220)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 227)\n  (:start . 222) (:id . 74))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 235)\n  (:start . 228) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 244)\n  (:start . 239) (:id . 77))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 253)\n  (:start . 245) (:id . 78))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 269) (:start . 254) (:id . 79))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 278)\n  (:start . 270) (:id . 80))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 287)\n  (:start . 279) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s329.4) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003014@unknown@formal@none@1@S@In vertebrates, five distinct DNA binding subunits are currently known which might extensively heterodimerize , thereby forming complexes with distinct transcriptional activity, DNA sequence specificity, and cell type- and cell stage- specific distribution.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "VB") (:stem . "heterodimerize") (:form . "heterodimerize")\n  (:end . 109) (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "VBG") (:stem . "form") (:form . "forming") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 137)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 167) (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 176)\n  (:start . 168) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 190)\n  (:start . 182) (:id . 67))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 202)\n  (:start . 191) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 212) (:start . 208)\n  (:id . 71))\n ((:tag . "NN") (:stem . "type-") (:form . "type-") (:end . 218)\n  (:start . 213) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . "NN") (:stem . "stage-") (:form . "stage-") (:end . 234)\n  (:start . 228) (:id . 75))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 243)\n  (:start . 235) (:id . 76))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 256)\n  (:start . 244) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x329.5.1) (:span 77 82)))\n (:hscopes ((:id . :x329.5.1) (:span 77 256)))\n (:identifiers (:sid . :s329.5) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003015@unknown@formal@none@1@S@The activity of DNA binding NF-kappa B dimers is tightly controlled by accessory proteins called I kappa B subunits of which there are also five different species currently known in vertebrates.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 96) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 154)\n  (:start . 145) (:id . 67))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 193)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s329.6) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003016@unknown@formal@none@1@S@I kappa B proteins inhibit DNA binding and prevent nuclear uptake of NF-kappa B complexes.@(((:tag . "NN") (:stem . "i") (:form . "I") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s329.7) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003017@unknown@formal@none@1@S@An exception is the Bcl-3 protein which in addition can function as a transcription activating subunit in th nucleus.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-3") (:form . "Bcl-3") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "th") (:form . "th") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s329.8) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003018@unknown@formal@none@1@S@Other I kappa B proteins are rather involved in terminating NF-kappa B 's activity in the nucleus.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "terminate") (:form . "terminating") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s329.9) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5003021@unknown@formal@none@1@S@Interference with the activation or activity of NF-kappa B may be beneficial in suppressing toxic/septic shock, graft-vs-host reactions, acute inflammatory reactions, acute phase response, and radiation damage.@(((:tag . "NN") (:stem . "interference") (:form . "Interference") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "toxic/septic") (:form . "toxic/septic") (:end . 104)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "graft-vs-host") (:form . "graft-vs-host")\n  (:end . 125) (:start . 112) (:id . 59))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 155)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 178)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 187)\n  (:start . 179) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 202)\n  (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 209)\n  (:start . 203) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x329.12.1) (:span 59 62)))\n (:hscopes ((:id . :x329.12.1) (:span 59 209)))\n (:identifiers (:sid . :s329.12) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003022@unknown@formal@none@1@S@The inhibition of NF-kappa B activation by antioxidants and specific protease inhibitors may provide a pharmacological basis for interfering with these acute processes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pharmacological") (:form . "pharmacological")\n  (:end . 118) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 124)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 140)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 157)\n  (:start . 152) (:id . 63))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 167)\n  (:start . 158) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x329.13.1) (:span 89 92)))\n (:hscopes ((:id . :x329.13.1) (:span 89 167)))\n (:identifiers (:sid . :s329.13) (:did . :|94280766|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003023@unknown@formal@none@1@S@Pentoxifylline for the treatment of infection with human immunodeficiency virus.@(((:tag . "NNP") (:stem . "Pentoxifylline") (:form . "Pentoxifylline")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 73) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s330.1) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003024@unknown@formal@none@1@S@Cytokine dysregulation in human immunodeficiency virus type 1 (HIV-1) infection has been documented in numerous studies and has been cited as an important component in the pathogenesis of this retroviral infection.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 48) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "cite") (:form . "cited") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 154)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 164)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 184)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 192) (:start . 188)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 203)\n  (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 213)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s330.2) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003025@unknown@formal@none@1@S@Pharmacological modification of cytokine dysregulation, therefore, has been suggested as a therapeutic modality for HIV-1 infection.@(((:tag . "JJ") (:stem . "pharmacological") (:form . "Pharmacological")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 28)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 54) (:start . 41) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 47))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 65)\n  (:start . 56) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "modality") (:form . "modality") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x330.3.1) (:span 76 85)))\n (:hscopes ((:id . :x330.3.1) (:span 0 131)))\n (:identifiers (:sid . :s330.3) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003026@unknown@formal@none@1@S@Dr. Dezube of Beth Israel Hospital (Boston) concisely reviews the state of our knowledge regarding the effects of pentoxifylline on expression of tumor necrosis factor-alpha, a cytokine known to influence HIV-1 replication and to play a possible role in the clinical manifestations of advanced infection with this virus.@(((:tag . "NNP") (:stem . "Dr.") (:form . "Dr.") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Dezube") (:form . "Dezube") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Beth") (:form . "Beth") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Israel") (:form . "Israel") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "Hospital") (:form . "Hospital") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . 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"advanced") (:end . 293)\n  (:start . 285) (:id . 88))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 303)\n  (:start . 294) (:id . 89))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 308) (:start . 304)\n  (:id . 90))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 313) (:start . 309)\n  (:id . 91))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 319)\n  (:start . 314) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 320) (:start . 319)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x330.4.1) (:span 237 245)))\n (:hscopes ((:id . :x330.4.1) (:span 237 319)))\n (:identifiers (:sid . :s330.4) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003027@unknown@formal@none@1@S@Pentoxifylline, a trisubstituted xanthine derivative, has been used to decrease blood viscosity and is reasonably well tolerated by most recipients of the drug.@(((:tag . "NNP") (:stem . "Pentoxifylline") (:form . "Pentoxifylline")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "trisubstitute") (:form . "trisubstituted")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "xanthine") (:form . "xanthine") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "viscosity") (:form . "viscosity") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "RB") (:stem . "reasonably") (:form . "reasonably") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "tolerate") (:form . "tolerated") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s330.5) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003028@unknown@formal@none@1@S@Results of preliminary studies, many of which were conducted by Dr.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Dr") (:form . "Dr") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s330.6) (:did . :|94281402|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003030@unknown@formal@none@1@S@Increased interleukin 2 transcription in murine lymphocytes by ciprofloxacin.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ciprofloxacin") (:form . "ciprofloxacin")\n  (:end . 76) (:start . 63) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s331.1) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003031@unknown@formal@none@1@S@The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fluoroquinolone") (:form . "fluoroquinolone")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "antibiotic") (:form . "antibiotic") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ciprofloxacin") (:form . "ciprofloxacin")\n  (:end . 45) (:start . 32) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cipro") (:form . "cipro") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "hyperproduction") (:form . "hyperproduction")\n  (:end . 78) (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 123) (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 149)\n  (:start . 139) (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 166)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 184)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s331.2) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5003033@unknown@formal@none@1@S@However, in contrast to human lymphocytes, IFN-gamma production was inhibited and IFN-gamma mRNA levels were unaffected at 24 h and only slightly upregulated at 48 and 72 h of culture in murine splenocytes incubated with cipro (20 micrograms/ml).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 157)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 183)\n  (:start . 176) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 193)\n  (:start . 187) (:id . 75))\n ((:tag . "NNS") (:stem . "splenocyte") (:form . "splenocytes") (:end . 205)\n  (:start . 194) (:id . 76))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 215)\n  (:start . 206) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cipro") (:form . "cipro") (:end . 226)\n  (:start . 221) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 230) (:start . 228)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "micrograms/ml") (:form . "micrograms/ml")\n  (:end . 244) (:start . 231) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 245) (:start . 244)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s331.4) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003034@unknown@formal@none@1@S@EL-4 cells were transfected with a plasmid containing the IL-2 promoter and enhancer region linked to the chloramphenicol acetyltransferase (CAT) reporter gene.@(((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 98) (:start . 92)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 121) (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 139) (:start . 122) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s331.5) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003035@unknown@formal@none@1@S@Analysis of CAT activity revealed that cipro enhanced IL-2 gene induction.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cipro") (:form . "cipro") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s331.6) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003036@unknown@formal@none@1@S@In addition, EL-4 cells incubated with ciprofloxacin showed an early peak and more activated nuclear factor of activated T cells (NFAT-1) as compared to control cells without antibiotics.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ciprofloxacin") (:form . "ciprofloxacin")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 59) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 160)\n  (:start . 153) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 174)\n  (:start . 167) (:id . 71))\n ((:tag . "NNS") (:stem . "antibiotic") (:form . "antibiotics") (:end . 186)\n  (:start . 175) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x331.7.1) (:span 167 174)))\n (:nscopes ((:id . :x331.7.1) (:span 167 186)))\n (:identifiers (:sid . :s331.7) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003037@unknown@formal@none@1@S@Cipro did not affect the nuclear transcription factors AP-1 or NFIL-2A.@(((:tag . "NNP") (:stem . "Cipro") (:form . "Cipro") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFIL-2A") (:form . "NFIL-2A") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x331.8.1) (:span 10 13)))\n (:nscopes ((:id . :x331.8.1) (:span 10 70)))\n (:identifiers (:sid . :s331.8) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003038@unknown@formal@none@1@S@Taken together, cipro inhibited IFN-gamma synthesis, but enhanced IL-2 production in murine lymphocytes by means of influencing NFAT-1 and causing an increased IL-2 transcription.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cipro") (:form . "cipro") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "influence") (:form . "influencing") (:end . 127)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 178) (:start . 165) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s331.9) (:did . :|94284067|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003040@unknown@formal@none@1@S@The interferon regulatory factor-1 (IRF-1) gene is both an immediate-early G1 phase gene and an S phase gene inducible by PRL in rat Nb2 T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 74) (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nb2") (:form . "Nb2") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 150)\n  (:start . 139) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s332.2) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003041@unknown@formal@none@1@S@To understand the mechanism by which PRL regulates the biphasic expression of IRF-1, we cloned the rat IRF-1 gene and functionally characterized the IRF-1 promoter.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "clone") (:form . "cloned") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 130)\n  (:start . 118) (:id . 63))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 163)\n  (:start . 155) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s332.3) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003042@unknown@formal@none@1@S@Upon transfection into Nb2 T cells, 1.7 kilobases (kb) of IRF-1 5'-flanking DNA linked to a chloramphenicol acetyl transferase (CAT) reporter gene mediated a 30-fold induction of CAT enzyme activity in response to 24 h of PRL stimulation.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nb2") (:form . "Nb2") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1.7") (:form . "1.7") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 75)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 86) (:start . 80)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 107) (:start . 92) (:id . 61))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 155)\n  (:start . 147) (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "30-fold") (:form . "30-fold") (:end . 165)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 175)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 182) (:start . 179)\n  (:id . 74))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 189)\n  (:start . 183) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 198)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 77))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 210)\n  (:start . 202) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 213) (:start . 211)\n  (:id . 79))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 216) (:start . 214)\n  (:id . 80))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 218) (:start . 217)\n  (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 225) (:start . 222)\n  (:id . 83))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 237)\n  (:start . 226) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s332.4) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003043@unknown@formal@none@1@S@Deletion mutants containing 1.3 , 0.6 , and 0.2 kb 5'-flanking DNA were incrementally less transcriptionally active, although 0.2 kb still mediated a 12-fold induction by PRL.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "CD") (:stem . "1.3") (:form . "1.3") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "CD") (:stem . "0.6") (:form . "0.6") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "RB") (:stem . "incrementally") (:form . "incrementally")\n  (:end . 85) (:start . 72) (:id . 55))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 108) (:start . 91) (:id . 57))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "12-fold") (:form . "12-fold") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s332.5) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003044@unknown@formal@none@1@S@The sequence between -1.7 and -0.2 kb linked to a heterologous thymidine kinase promoter failed to respond to PRL stimulation, suggesting that the activity of upstream PRL response elements may require an interaction with promoter-proximal elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "CD") (:stem . "-1.7") (:form . "-1.7") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-0.2") (:form . "-0.2") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 44) (:start . 38)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 62)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 95) (:start . 89)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 167)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "prl") (:form . "PRL") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 180)\n  (:start . 172) (:id . 70))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 201)\n  (:start . 194) (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 216)\n  (:start . 205) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 221) (:start . 217)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "promoter-proximal") (:form . "promoter-proximal")\n  (:end . 239) (:start . 222) (:id . 77))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 248)\n  (:start . 240) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x332.6.1) (:span 190 193))\n  ((:id . :x332.6.2) (:span 127 137)))\n (:ncues ((:id . :x332.6.3) (:span 89 95)))\n (:hscopes ((:id . :x332.6.1) (:span 190 248))\n  ((:id . :x332.6.2) (:span 127 248)))\n (:nscopes ((:id . :x332.6.3) (:span 89 125)))\n (:identifiers (:sid . :s332.6) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003045@unknown@formal@none@1@S@By assaying CAT enzyme activity across a 24-h PRL induction time course, we were able to assign G1 vs. S phase PRL responses of the IRF-1 gene to different regions of the IRF-1 5'-flanking and promoter DNA.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "assay") (:form . "assaying") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "24-h") (:form . "24-h") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "VB") (:stem . "assign") (:form . "assign") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "IN") (:stem . "vs.") (:form . "vs.") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 110)\n  (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "prl") (:form . "PRL") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 124)\n  (:start . 115) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 67))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 142) (:start . 138)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 155)\n  (:start . 146) (:id . 71))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 163)\n  (:start . 156) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 74))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 176)\n  (:start . 171) (:id . 75))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 188)\n  (:start . 177) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 77))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 201)\n  (:start . 193) (:id . 78))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 205) (:start . 202)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s332.7) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003046@unknown@formal@none@1@S@The 0.2-kb IRF-CAT construct was induced by PRL stimulation during the G1 phase of the cell cycle.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "0.2-kb") (:form . "0.2-kb") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IRF-CAT") (:form . "IRF-CAT") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s332.8) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003047@unknown@formal@none@1@S@In contrast, the 1.7-kb IRF-CAT construct was inducible by PRL during both G1 and S phase of the cell cycle.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "1.7-kb") (:form . "1.7-kb") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NNP") (:stem . "IRF-CAT") (:form . "IRF-CAT") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 107)\n  (:start . 102) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s332.9) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003048@unknown@formal@none@1@S@Hence, the PRL-induced biphasic expression of the IRF-1 gene appears to be controlled by separate PRL-responsive elements:@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "prl-induced") (:form . "PRL-induced") (:end . 22)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "JJ") (:stem . "prl-responsive") (:form . "PRL-responsive")\n  (:end . 112) (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x332.10.1) (:span 61 68)))\n (:hscopes ((:id . :x332.10.1) (:span 7 121)))\n (:identifiers (:sid . :s332.10) (:did . :|94285936|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003050@unknown@formal@none@1@S@Description and functional implications of a novel mutation in the sex-determining gene SRY.@(((:tag . "NN") (:stem . "description") (:form . "Description") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 39)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sex-determining") (:form . "sex-determining")\n  (:end . 82) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s333.1) (:did . :|94290489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003051@unknown@formal@none@1@S@The sex-determining gene SRY was screened for molecular alteration in an XY sex-reversed female by single-strand conformation polymorphism (SSCP) technique.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "sex-determining") (:form . "sex-determining")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "screen") (:form . "screened") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "xy") (:form . "XY") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sex-reversed") (:form . "sex-reversed") (:end . 88)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "female") (:form . "female") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "single-strand") (:form . "single-strand")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 125)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 138)\n  (:start . 126) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "SSCP") (:form . "SSCP") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 155)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s333.2) (:did . :|94290489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003052@unknown@formal@none@1@S@An A-to-G transition was detected which leads to an exchange of a tyrosine by a cysteine in the SRY protein.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "A-to-G") (:form . "A-to-G") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s333.3) (:did . :|94290489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003053@unknown@formal@none@1@S@The affected tyrosine residue located at the C terminus of the DNA binding protein is evolutionarily strongly conserved among the members of the HMG box containing proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 100) (:start . 86) (:id . 57))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s333.4) (:did . :|94290489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003054@unknown@formal@none@1@S@Using gel shift assay and peptide synthesis such a mutation is shown to abolish the SRY protein DNA binding ability.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "abolish") (:form . "abolish") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sry") (:form . "SRY") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s333.5) (:did . :|94290489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003055@unknown@formal@none@1@S@The involvement of this particular amino acid in the binding specificity is also discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s333.6) (:did . :|94290489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003056@unknown@formal@none@1@S@Evidence for a trans-acting activator function regulating the expression of the human CD5 antigen.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "trans-acting") (:form . "trans-acting") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd5") (:form . "CD5") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s334.1) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003057@unknown@formal@none@1@S@Interspecies somatic cell hybrids were generated by fusing the mouse T-lymphoma cell line, BW5147, with normal human T lymphocytes at different stages of differentiation.@(((:tag . "JJ") (:stem . "interspecies") (:form . "Interspecies") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "somatic") (:form . "somatic") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "fuse") (:form . "fusing") (:end . 58) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "T-lymphoma") (:form . "T-lymphoma") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BW5147") (:form . "BW5147") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 169) (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s334.2) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003058@unknown@formal@none@1@S@Thymocytes, activated peripheral T lymphocytes, or an activated T-cell clone were used as human partners, respectively, in three independent fusions.@(((:tag . "NNP") (:stem . "Thymocyte") (:form . "Thymocytes") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 118)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 140)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "fusion") (:form . "fusions") (:end . 148)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s334.3) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003060@unknown@formal@none@1@S@Analysis at the phenotype and genetic level showed that lack of CD5 expression was due neither to segregation of human autosome 11, on which the CD5 gene has been mapped, nor to deletion of the CD5 structural gene.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 50) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "segregation") (:form . "segregation") (:end . 109)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "autosome") (:form . "autosome") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 169)\n  (:start . 163) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 73))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 75))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 186)\n  (:start . 178) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 197) (:start . 194)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 208)\n  (:start . 198) (:id . 80))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 213) (:start . 209)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x334.5.1) (:span 87 94 171 174))\n  ((:id . :x334.5.3) (:span 56 60)))\n (:nscopes ((:id . :x334.5.1) (:span 87 213))\n  ((:id . :x334.5.3) (:span 56 78)))\n (:identifiers (:sid . :s334.5) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003061@unknown@formal@none@1@S@Furthermore, loss of CD5 surface expression correlated with the absence of specific mRNA.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s334.6) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003062@unknown@formal@none@1@S@Since these hybrids preferentially segregate human chromosomes, these results indicate the existence of a non-syntenic trans-active locus, or loci, positively controlling the expression of the human CD5 gene.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "segregate") (:form . "segregate") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "non-syntenic") (:form . "non-syntenic") (:end . 118)\n  (:start . 106) (:id . 57))\n ((:tag . "JJ") (:stem . "trans-active") (:form . "trans-active") (:end . 131)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 137)\n  (:start . 132) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "locus") (:form . "loci") (:end . 146)\n  (:start . 142) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 158)\n  (:start . 148) (:id . 64))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 170)\n  (:start . 159) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 185)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 198)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "cd5") (:form . "CD5") (:end . 202) (:start . 199)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s334.7) (:did . :|94314370|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003063@unknown@formal@none@1@S@Prevalence of aneuploidy, overexpressed ER, and overexpressed EGFR in random breast aspirates of women at high and low risk for breast cancer.@(((:tag . "NNP") (:stem . "Prevalence") (:form . "Prevalence") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "aneuploidy") (:form . "aneuploidy") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "overexpressed") (:form . "overexpressed")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "egfr") (:form . "EGFR") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "aspirate") (:form . "aspirates") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 141)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s335.1) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003064@unknown@formal@none@1@S@Breast tissue biomarkers which accurately predict breast cancer development within a 10 year period in high risk women are needed but currently not available.@(((:tag . "NN") (:stem . "breast") (:form . "Breast") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "biomarker") (:form . "biomarkers") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "accurately") (:form . "accurately") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 75)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 82)\n  (:start . 76) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "year") (:form . "year") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x335.2.1) (:span 144 147)))\n (:nscopes ((:id . :x335.2.1) (:span 144 157)))\n (:identifiers (:sid . :s335.2) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003065@unknown@formal@none@1@S@We initiated this study to determine 1 ) the prevalence of one or more breast tissue abnormalities in a group of women at high risk for breast cancer, and 2 ) if the prevalence of biomarker abnormalities is greater in high risk than in low risk women.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "initiate") (:form . "initiated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "prevalence") (:form . "prevalence") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 98)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 131) (:start . 127)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 142)\n  (:start . 136) (:id . 68))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 149)\n  (:start . 143) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . 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5003066@unknown@formal@none@1@S@Eligible high risk women were those with a first degree relative with breast cancer, prior breast cancer, or precancerous mastopathy.@(((:tag . "JJ") (:stem . "eligible") (:form . "Eligible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "precancerous") (:form . "precancerous") (:end . 121)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "mastopathy") (:form . "mastopathy") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s335.4) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003067@unknown@formal@none@1@S@Low risk women were those without these or other major identifiable risk factors.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "identifiable") (:form . "identifiable") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x335.5.1) (:span 26 33)))\n (:nscopes ((:id . :x335.5.1) (:span 26 80)))\n (:identifiers (:sid . :s335.5) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003068@unknown@formal@none@1@S@Ductal cells were obtained via random fine needle aspirations and cytologically classified.@(((:tag . "JJ") (:stem . "ductal") (:form . "Ductal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "fine") (:form . "fine") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "needle") (:form . "needle") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "aspiration") (:form . "aspirations") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "cytologically") (:form . "cytologically")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "VBN") (:stem . "classify") (:form . "classified") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s335.6) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003070@unknown@formal@none@1@S@The prevalence of DNA aneuploidy was 30 %, overexpression of ER 10 %, and overexpression of EGFR 35 %, in the 206 high risk women whose median 10 year Gail risk (projected probability) of developing breast cancer was 4.5 %.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "prevalence") (:form . "prevalence") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "aneuploidy") (:form . "aneuploidy") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 57) (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 88) (:start . 74) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "EGFR") (:form . "EGFR") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 65))\n ((:tag . "CD") (:stem . "206") (:form . "206") (:end . 113) (:start . 110)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 118) (:start . 114)\n  (:id . 67))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 123) (:start . 119)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 129)\n  (:start . 124) (:id . 69))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 135)\n  (:start . 130) (:id . 70))\n ((:tag . "JJ") (:stem . "median") (:form . "median") (:end . 142)\n  (:start . 136) (:id . 71))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 145) (:start . 143)\n  (:id . 72))\n ((:tag . "NN") (:stem . "year") (:form . "year") (:end . 150) (:start . 146)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gail") (:form . "Gail") (:end . 155) (:start . 151)\n  (:id . 74))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 160) (:start . 156)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "project") (:form . "projected") (:end . 171)\n  (:start . 162) (:id . 77))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 183)\n  (:start . 172) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 80))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 198)\n  (:start . 188) (:id . 81))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 205)\n  (:start . 199) (:id . 82))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 212)\n  (:start . 206) (:id . 83))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 216) (:start . 213)\n  (:id . 84))\n ((:tag . "CD") (:stem . "4.5") (:form . "4.5") (:end . 220) (:start . 217)\n  (:id . 85))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 222) (:start . 221)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s335.8) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003071@unknown@formal@none@1@S@The prevalence of aneuploidy and overexpressed EGFR was significantly higher in the high risk women than in the 25 low risk controls (p < 0.002), whose median 10 year Gail risk was 0.7 %.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "prevalence") (:form . "prevalence") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aneuploidy") (:form . "aneuploidy") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "overexpressed") (:form . "overexpressed")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "egfr") (:form . "EGFR") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 76) (:start . 70)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "CD") (:stem . "0.002") (:form . "0.002") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 69))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . "JJ") (:stem . "median") (:form . "median") (:end . 158)\n  (:start . 152) (:id . 71))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 161) (:start . 159)\n  (:id . 72))\n ((:tag . "NN") (:stem . "year") (:form . "year") (:end . 166) (:start . 162)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gail") (:form . "Gail") (:end . 171) (:start . 167)\n  (:id . 74))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 176) (:start . 172)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 180) (:start . 177)\n  (:id . 76))\n ((:tag . "CD") (:stem . "0.7") (:form . "0.7") (:end . 184) (:start . 181)\n  (:id . 77))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 186) (:start . 185)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s335.9) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003072@unknown@formal@none@1@S@The difference in the prevalence of ER overexpression between high and low risk groups was not statistically significant (p = 0.095).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prevalence") (:form . "prevalence") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 53) (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 108) (:start . 95) (:id . 58))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.095") (:form . "0.095") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x335.10.1) (:span 91 94)))\n (:nscopes ((:id . :x335.10.1) (:span 91 132)))\n (:identifiers (:sid . :s335.10) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003073@unknown@formal@none@1@S@This may be due to the low prevalence of overexpressed ER and the small number of controls.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "prevalence") (:form . "prevalence") (:end . 37)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "overexpressed") (:form . "overexpressed")\n  (:end . 54) (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x335.11.1) (:span 5 8)))\n (:hscopes ((:id . :x335.11.1) (:span 5 90)))\n (:identifiers (:sid . :s335.11) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003074@unknown@formal@none@1@S@A significant difference was noted in the prevalence of one or more abnormal biomarkers between the high risk and low risk women (p < 0.001).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "prevalence") (:form . "prevalence") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "biomarker") (:form . "biomarkers") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s335.12) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003075@unknown@formal@none@1@S@A large prospective trial is needed to determine if one or more of these biomarkers, is predictive of breast cancer development.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "prospective") (:form . "prospective") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "trial") (:form . "trial") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "biomarker") (:form . "biomarkers") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 108)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 127)\n  (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x335.13.1) (:span 56 58))\n  ((:id . :x335.13.2) (:span 49 51)))\n (:hscopes ((:id . :x335.13.1) (:span 52 63))\n  ((:id . :x335.13.2) (:span 49 127)))\n (:identifiers (:sid . :s335.13) (:did . :|95072277|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003076@unknown@formal@none@1@S@[The changes in glucocorticoid receptors in peripheral leukocytes in asthmatic subjects]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 12)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 30) (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s336.1) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003077@unknown@formal@none@1@S@The number of glucocorticoid receptors (GCR) in peripheral leukocytes was determined by radioligand-binding assay in extrinsic and intrinsic asthmatics.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "radioligand-binding")\n  (:form . "radioligand-binding") (:end . 107) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "extrinsic") (:form . "extrinsic") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "asthmatic") (:form . "asthmatics") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s336.2) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003078@unknown@formal@none@1@S@Their corresponding plasma cortisol levels were assessed.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s336.3) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003080@unknown@formal@none@1@S@Besides, there was also a linear correlation between the number of GCR and the age of the initial attack of asthma.@(((:tag . "IN") (:stem . "besides") (:form . "Besides") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 97)\n  (:start . 90) (:id . 60))\n ((:tag . "NN") (:stem . "attack") (:form . "attack") (:end . 104)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 114)\n  (:start . 108) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s336.5) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003081@unknown@formal@none@1@S@No difference in plasma cortisol level was found between asthmatics and healthy subjects.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "asthmatic") (:form . "asthmatics") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x336.6.1) (:span 0 2)))\n (:nscopes ((:id . :x336.6.1) (:span 0 88)))\n (:identifiers (:sid . :s336.6) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003082@unknown@formal@none@1@S@These findings suggest that there is no primary and general impairment of glucocorticoid metabolism in the asthmatics, but the number of GCR in the asthmatics is lower than that in healthy controls.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "impairment") (:form . "impairment") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "asthmatic") (:form . "asthmatics") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "asthmatic") (:form . "asthmatics") (:end . 158)\n  (:start . 148) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 167) (:start . 162)\n  (:id . 69))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 188)\n  (:start . 181) (:id . 73))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x336.7.2) (:span 15 22)))\n (:ncues ((:id . :x336.7.1) (:span 37 39)))\n (:hscopes ((:id . :x336.7.2) (:span 15 197)))\n (:nscopes ((:id . :x336.7.1) (:span 37 117)))\n (:identifiers (:sid . :s336.7) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003083@unknown@formal@none@1@S@The decrease of the number of GCR in asthmatics, we think, is related to heredity and repeated attacks of asthma.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "asthmatic") (:form . "asthmatics") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "think") (:form . "think") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 69)\n  (:start . 62) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "NN") (:stem . "heredity") (:form . "heredity") (:end . 81)\n  (:start . 73) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 94)\n  (:start . 86) (:id . 60))\n ((:tag . "NNS") (:stem . "attack") (:form . "attacks") (:end . 102)\n  (:start . 95) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 112)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x336.8.1) (:span 52 57)))\n (:hscopes ((:id . :x336.8.1) (:span 0 112)))\n (:identifiers (:sid . :s336.8) (:did . :|95104037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003084@unknown@formal@none@1@S@Alternate immune system targets for TCDD: lymphocyte stem cells and extrathymic T-cell development.@(((:tag . "JJ") (:stem . "alternate") (:form . "Alternate") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "extrathymic") (:form . "extrathymic") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s337.1) (:did . :|95127261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003085@unknown@formal@none@1@S@We here summarize evidence that thymic atrophy induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can be mediated, at least in part, by damage to extrathymic T-cell precursors in bone marrow and fetal liver.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "summarize") (:form . "summarize") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "atrophy") (:form . "atrophy") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "2,3,7,8-tetrachlorodibenzo-p-dioxin")\n  (:form . "2,3,7,8-tetrachlorodibenzo-p-dioxin") (:end . 93) (:start . 58)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 99) (:start . 95)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "extrathymic") (:form . "extrathymic") (:end . 160)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 193)\n  (:start . 187) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 209)\n  (:start . 204) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s337.2) (:did . :|95127261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003086@unknown@formal@none@1@S@This atrophy induction does not involve apoptotic mechanisms in thymocytes affected by the bcl-2 proto-oncogene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "atrophy") (:form . "atrophy") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 111) (:start . 97) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x337.3.1) (:span 28 31)))\n (:nscopes ((:id . :x337.3.1) (:span 28 111)))\n (:identifiers (:sid . :s337.3) (:did . :|95127261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003087@unknown@formal@none@1@S@TCDD mediates atrophy induction through its specific receptor (the AhR) and not through effects on the estrogen receptor.@(((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "atrophy") (:form . "atrophy") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ahr") (:form . "AhR") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x337.4.1) (:span 76 79)))\n (:nscopes ((:id . :x337.4.1) (:span 76 120)))\n (:identifiers (:sid . :s337.4) (:did . :|95127261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003088@unknown@formal@none@1@S@Both TCDD and estradiol induce extrathymic T-cell differentiation in the liver.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "estradiol") (:form . "estradiol") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "extrathymic") (:form . "extrathymic") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 65) (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s337.5) (:did . :|95127261|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003090@unknown@formal@none@1@S@Alteration of structural order of human erythrocyte ghost membrane by glucocorticoids and the influence of the glucocorticoid receptor antagonist RU 486.@(((:tag . "NNP") (:stem . "Alteration") (:form . "Alteration") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "ghost") (:form . "ghost") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 85) (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 125) (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 145)\n  (:start . 135) (:id . 60))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 152) (:start . 149)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s338.1) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003091@unknown@formal@none@1@S@High-dose pulse glucocorticoid therapy has been used successfully in the clinic in severe pathological conditions for about 20 years.@(((:tag . "JJ") (:stem . "high-dose") (:form . "High-dose") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "pulse") (:form . "pulse") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 30) (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "clinic") (:form . "clinic") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "pathological") (:form . "pathological") (:end . 102)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 113)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s338.2) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003092@unknown@formal@none@1@S@The mode of glucocorticoid action after administration of such megadoses is inexplicable up to now.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 26) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "administration") (:form . "administration")\n  (:end . 54) (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "megados") (:form . "megadoses") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inexplicable") (:form . "inexplicable") (:end . 88)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s338.3) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003093@unknown@formal@none@1@S@It is supposed that some effects may be due to membrane alterations.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "suppose") (:form . "supposed") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x338.4.1) (:span 33 36)) ((:id . :x338.4.2) (:span 6 14)))\n (:hscopes ((:id . :x338.4.1) (:span 33 67)) ((:id . :x338.4.2) (:span 6 67)))\n (:identifiers (:sid . :s338.4) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003094@unknown@formal@none@1@S@In the present in-vitro experiments the effect of dexamethasone, of further glucocorticoids, and of the glucocorticoid receptor antagonist RU 486, on structural order of human erythrocyte ghost membranes was investigated by determining the steady-state fluorescence anisotropy of diphenylhexatriene (DPH).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "FW") (:stem . "in-vitro") (:form . "in-vitro") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 91) (:start . 76) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 118) (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 166)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 187)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "ghost") (:form . "ghost") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 203)\n  (:start . 194) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 207) (:start . 204)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 220)\n  (:start . 208) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 223) (:start . 221)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 235)\n  (:start . 224) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 252)\n  (:start . 240) (:id . 78))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 265)\n  (:start . 253) (:id . 79))\n ((:tag . "NN") (:stem . "anisotropy") (:form . "anisotropy") (:end . 276)\n  (:start . 266) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 279) (:start . 277)\n  (:id . 81))\n ((:tag . "NN") (:stem . "diphenylhexatriene") (:form . "diphenylhexatriene")\n  (:end . 298) (:start . 280) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 300) (:start . 299)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "DPH") (:form . "DPH") (:end . 303) (:start . 300)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 304) (:start . 303)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s338.5) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003095@unknown@formal@none@1@S@Dexamethasone was found to induce a significant decrease in membrane structural order at concentrations of about 10(-6) M in a concentration-dependent manner.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 103) (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "NNP") (:stem . "10(-6)") (:form . "10(-6)") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 150) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 157)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s338.6) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003096@unknown@formal@none@1@S@We found a correlation between the uptake of dexamethasone by the ghost membranes and the decrease in the structural order.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 22)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ghost") (:form . "ghost") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s338.7) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003097@unknown@formal@none@1@S@The other glucocorticoids tested, methylprednisolone and corticosterone, were also effective at concentrations of 10(-5) M or greater.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 32) (:start . 26)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "methylprednisolone") (:form . "methylprednisolone")\n  (:end . 52) (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "corticosterone") (:form . "corticosterone")\n  (:end . 71) (:start . 57) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 110) (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "10(-5)") (:form . "10(-5)") (:end . 120)\n  (:start . 114) (:id . 57))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s338.8) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003098@unknown@formal@none@1@S@We observed no change in membrane structural order with RU 486 up to a concentration of 10(-4) M.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 84) (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "10(-4)") (:form . "10(-4)") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x338.9.1) (:span 12 14)))\n (:nscopes ((:id . :x338.9.1) (:span 12 96)))\n (:identifiers (:sid . :s338.9) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003100@unknown@formal@none@1@S@Thus, the glucocorticoid-induced membrane perturbation, the possibility to inhibit it by RU 486, and the inactivity of the structurally related progesterone, refer to relatively specific binding sites for the glucocorticoids in the membrane of erythrocyte ghosts.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "glucocorticoid-induced") (:end . 32) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "perturbation") (:form . "perturbation") (:end . 54)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inactivity") (:form . "inactivity") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 135)\n  (:start . 123) (:id . 63))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 156)\n  (:start . 144) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "refer") (:form . "refer") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 177)\n  (:start . 167) (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 200)\n  (:start . 195) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 224) (:start . 209) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 77))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 240)\n  (:start . 232) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 79))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 255)\n  (:start . 244) (:id . 80))\n ((:tag . "NNS") (:stem . "ghost") (:form . "ghosts") (:end . 262)\n  (:start . 256) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x338.11.1) (:span 158 166)))\n (:hscopes ((:id . :x338.11.1) (:span 158 262)))\n (:identifiers (:sid . :s338.11) (:did . :|95154979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003101@unknown@formal@none@1@S@Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.@(((:tag . "NNP") (:stem . "Cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 28) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s339.1) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003102@unknown@formal@none@1@S@Present evidence indicates a pathway of signal transmission in T cells that is outlined in figure 1.@(((:tag . "JJ") (:stem . "present") (:form . "Present") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "outline") (:form . "outlined") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "figure") (:form . "figure") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s339.2) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003103@unknown@formal@none@1@S@The elevation in intracellular calcium that is induced by interactions at the antigen receptor leads to the activation of the calcium-dependent phosphatase calcineurin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 143) (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 155)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 167)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s339.3) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003104@unknown@formal@none@1@S@This in turn leads to the nuclear association of the cytosolic component of NF-ATc.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 45)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s339.4) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003105@unknown@formal@none@1@S@The activation of calcineurin and the nuclear import of NF-ATc can both be blocked by cyclosporin A or FK506 in complex with their respective immunophilins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 141)\n  (:start . 131) (:id . 65))\n ((:tag . "NNS") (:stem . "immunophilin") (:form . "immunophilins")\n  (:end . 155) (:start . 142) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s339.5) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003106@unknown@formal@none@1@S@Once in the nucleus, NF-ATc interacts with NF-ATn to form an active transcriptional complex.@(((:tag . "RB") (:stem . "once") (:form . "Once") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-ATn") (:form . "NF-ATn") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 83) (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s339.6) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003107@unknown@formal@none@1@S@NF-ATn is a ubiquitous protein, can be synthesized in response to PMA, and has many similarities to AP-1.@(((:tag . "NNP") (:stem . "NF-ATn") (:form . "NF-ATn") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 50)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 96)\n  (:start . 84) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s339.7) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003108@unknown@formal@none@1@S@The mechanism by which NF-ATc enters the nucleus is unknown, and although it appears to require calcineurin, NF-ATc has not yet been shown to be an in vivo substrate of calcineurin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "enter") (:form . "enters") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 107)\n  (:start . 96) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 138)\n  (:start . 133) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 155) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 165)\n  (:start . 156) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 180)\n  (:start . 169) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x339.8.2) (:span 77 84)))\n (:ncues ((:id . :x339.8.1) (:span 120 123)))\n (:hscopes ((:id . :x339.8.2) (:span 74 107)))\n (:nscopes ((:id . :x339.8.1) (:span 109 180)))\n (:identifiers (:sid . :s339.8) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003110@unknown@formal@none@1@S@Although NF-ATp copurifies with NF-ATc, there is as yet no understanding of how NF-ATp is functioning in vivo.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "copurify") (:form . "copurifies") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 72) (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "function") (:form . "functioning") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x339.10.1) (:span 56 58)))\n (:nscopes ((:id . :x339.10.1) (:span 56 109)))\n (:identifiers (:sid . :s339.10) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003111@unknown@formal@none@1@S@Now that these proteins are purified and cloned, the major goals will be to understand their role and the roles of other family members in thymic development.@(((:tag . "RB") (:stem . "now") (:form . "Now") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "goal") (:form . "goals") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 86)\n  (:start . 76) (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 92)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 127)\n  (:start . 121) (:id . 65))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 135)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 145)\n  (:start . 139) (:id . 68))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 157)\n  (:start . 146) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s339.11) (:did . :|95193668|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003112@unknown@formal@none@1@S@Changes in triiodothyronine (T3) mononuclear leukocyte receptor kinetics after T3 administration and multiple cold-air exposures.@(((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "triiodothyronine") (:form . "triiodothyronine")\n  (:end . 27) (:start . 11) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "administration") (:form . "administration")\n  (:end . 96) (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "JJ") (:stem . "cold-air") (:form . "cold-air") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 128)\n  (:start . 119) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s340.1) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003113@unknown@formal@none@1@S@Repeated cold-air exposures increase human triiodothyronine (T3) plasma clearance rates.@(((:tag . "VBN") (:stem . "repeat") (:form . "Repeated") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cold-air") (:form . "cold-air") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "triiodothyronine") (:form . "triiodothyronine")\n  (:end . 59) (:start . 43) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s340.2) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003114@unknown@formal@none@1@S@To study the response of the nuclear T3 receptor (NT3R) in this condition, binding characteristics were analyzed in human mononuclear leukocytes (MNL).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NT3R") (:form . "NT3R") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 63) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "condition") (:form . "condition") (:end . 73)\n  (:start . 64) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 58))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 98) (:start . 83) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 133)\n  (:start . 122) (:id . 64))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MNL") (:form . "MNL") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s340.3) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003115@unknown@formal@none@1@S@In addition, we supplemented one group of individuals with a daily oral replacement dose of T3 to isolate the influence of serum thyroxine (T4) and thyrotropin (TSH) levels on receptor kinetics.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "supplement") (:form . "supplemented") (:end . 28)\n  (:start . 16) (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "daily") (:form . "daily") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "oral") (:form . "oral") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "T3") (:form . "T3") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "thyroxine") (:form . "thyroxine") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t4") (:form . "T4") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "thyrotropin") (:form . "thyrotropin") (:end . 159)\n  (:start . 148) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TSH") (:form . "TSH") (:end . 164) (:start . 161)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 172)\n  (:start . 166) (:id . 74))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 175) (:start . 173)\n  (:id . 75))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 184)\n  (:start . 176) (:id . 76))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 193)\n  (:start . 185) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s340.4) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003116@unknown@formal@none@1@S@The subjects were exposed to cold air (4 degrees C) twice/d, 30 min/exposure, for a total of 80 exposures.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cold") (:form . "cold") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "air") (:form . "air") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "RB") (:stem . "twice/d") (:form . "twice/d") (:end . 59)\n  (:start . 52) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 55))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 63) (:start . 61)\n  (:id . 56))\n ((:tag . "NN") (:stem . "min/exposure") (:form . "min/exposure") (:end . 76)\n  (:start . 64) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 60))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 89) (:start . 84)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 62))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 95) (:start . 93)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 105)\n  (:start . 96) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s340.5) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003117@unknown@formal@none@1@S@The T3- subjects received placebo [n = 8] and the T3+ subjects received T3 (30 micrograms/d) [n = 8] in a double-blind fashion.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "t3-") (:form . "T3-") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "receive") (:form . "received") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "placebo") (:form . "placebo") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "t3+") (:form . "T3+") (:end . 53) (:start . 50)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 62)\n  (:start . 54) (:id . 55))\n ((:tag . "VBD") (:stem . "receive") (:form . "received") (:end . 71)\n  (:start . 63) (:id . 56))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 58))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 78) (:start . 76)\n  (:id . 59))\n ((:tag . "NN") (:stem . "micrograms/d") (:form . "micrograms/d") (:end . 91)\n  (:start . 79) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 94) (:start . 93)\n  (:id . 62))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 95) (:start . 94)\n  (:id . 63))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 97) (:start . 96)\n  (:id . 64))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 99) (:start . 98)\n  (:id . 65))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 100) (:start . 99)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "double-blind") (:form . "double-blind") (:end . 118)\n  (:start . 106) (:id . 69))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 126)\n  (:start . 119) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s340.6) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003118@unknown@formal@none@1@S@Mononuclear leukocytes were isolated from peripheral blood before the cold exposure and drug regimen began, and then after every 20 exposures.@(((:tag . "JJ") (:stem . "mononuclear") (:form . "Mononuclear") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cold") (:form . "cold") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "regiman") (:form . "regimen") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "VBD") (:stem . "begin") (:form . "began") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 141)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s340.7) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003120@unknown@formal@none@1@S@In the T3+ group, serum total thyroxine (TT4), free T4 (FT4), and TSH were approx 50% lower than both basal and T3-values.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "t3+") (:form . "T3+") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "thyroxine") (:form . "thyroxine") (:end . 39)\n  (:start . 30) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tt4") (:form . "TT4") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 51) (:start . 47)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t4") (:form . "T4") (:end . 54) (:start . 52)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FT4") (:form . "FT4") (:end . 59) (:start . 56)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TSH") (:form . "TSH") (:end . 69) (:start . 66)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 74) (:start . 70)\n  (:id . 62))\n ((:tag . "RB") (:stem . "approx") (:form . "approx") (:end . 81)\n  (:start . 75) (:id . 63))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 84) (:start . 82)\n  (:id . 64))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 85) (:start . 84)\n  (:id . 65))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 91) (:start . 86)\n  (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 107)\n  (:start . 102) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "t3-value") (:form . "T3-values") (:end . 121)\n  (:start . 112) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s340.9) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003121@unknown@formal@none@1@S@The log10Kd increased 0.304 ± 0.139 (p < 0.04) and the log10MBC increased 0.49 ± 0.10 (p < 0.001) in the T3+ subjects compared to baseline.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "log10kd") (:form . "log10Kd") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "CD") (:stem . "0.304") (:form . "0.304") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "0.139") (:form . "0.139") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "CD") (:stem . "0.04") (:form . "0.04") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 54))\n ((:tag . "NN") (:stem . "log10mbc") (:form . "log10MBC") (:end . 63)\n  (:start . 55) (:id . 55))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 73)\n  (:start . 64) (:id . 56))\n ((:tag . "CD") (:stem . "0.49") (:form . "0.49") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 85) (:start . 81)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 88) (:start . 87)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 90) (:start . 89)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 96) (:start . 91)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "t3+") (:form . "T3+") (:end . 108) (:start . 105)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 117)\n  (:start . 109) (:id . 68))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 126)\n  (:start . 118) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 70))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 138)\n  (:start . 130) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s340.10) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003122@unknown@formal@none@1@S@This change in MBC represents a 311 % increase in the MBC over baseline and a fivefold increase over placebo-treated subjects.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MBC") (:form . "MBC") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "311") (:form . "311") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MBC") (:form . "MBC") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 71)\n  (:start . 63) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fivefold") (:form . "fivefold") (:end . 86)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "placebo-treated") (:form . "placebo-treated")\n  (:end . 116) (:start . 101) (:id . 61))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s340.11) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003123@unknown@formal@none@1@S@The T3- group showed no change in MBC over the study.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t3-") (:form . "T3-") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 20) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MBC") (:form . "MBC") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x340.12.1) (:span 21 23)))\n (:nscopes ((:id . :x340.12.1) (:span 21 52)))\n (:identifiers (:sid . :s340.12) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003124@unknown@formal@none@1@S@These results describe for the first time the rapid modulation of the NT3R in response to the combined influence of cold exposure and reduced circulating T4 and TSH.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nt3r") (:form . "NT3R") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cold") (:form . "cold") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 153)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "t4") (:form . "T4") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TSH") (:form . "TSH") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s340.13) (:did . :|95201644|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003125@unknown@formal@none@1@S@BCL-6 and the molecular pathogenesis of B-cell lymphoma.@(((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s341.1) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003126@unknown@formal@none@1@S@The results presented identify the first genetic lesion associated with DLCL, the most clinically relevant form of NHL.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "lesion") (:form . "lesion") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DLCL") (:form . "DLCL") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NHL") (:form . "NHL") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s341.2) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003127@unknown@formal@none@1@S@Although no proof yet exists of a role for these lesions in DLCL pathogenesis, the feature of the BCL-6 gene product, its specific pattern of expression in B cells, and the clustering of lesions disrupting its regulatory domain strongly suggest that deregulation of BCL-6 expression may contribute to DLCL development.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "proof") (:form . "proof") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . 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(:end . 318) (:start . 317)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x341.3.1) (:span 283 286))\n  ((:id . :x341.3.2) (:span 237 244)))\n (:ncues ((:id . :x341.3.3) (:span 9 11)))\n (:hscopes ((:id . :x341.3.1) (:span 283 317))\n  ((:id . :x341.3.2) (:span 237 317)))\n (:nscopes ((:id . :x341.3.3) (:span 9 77)))\n (:identifiers (:sid . :s341.3) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003128@unknown@formal@none@1@S@A more precise definition of the role of BCL-6 in normal and neoplastic B-cell development is the goal of ongoing study of transgenic mice engineered either to express BCL-6 under heterologous promoters or lacking BCL-6 function due to targeted deletions.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neoplastic") (:form . "neoplastic") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "goal") (:form . "goal") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ongoing") (:form . "ongoing") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 138)\n  (:start . 134) (:id . 65))\n ((:tag . "VBN") (:stem . "engineer") (:form . "engineered") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 167)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 179)\n  (:start . 174) (:id . 71))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 192)\n  (:start . 180) (:id . 72))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 202)\n  (:start . 193) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 213)\n  (:start . 206) (:id . 75))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 219)\n  (:start . 214) (:id . 76))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 228)\n  (:start . 220) (:id . 77))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 232) (:start . 229)\n  (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 235) (:start . 233)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 244)\n  (:start . 236) (:id . 80))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 254)\n  (:start . 245) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x341.4.1) (:span 206 213)))\n (:nscopes ((:id . :x341.4.1) (:span 206 228)))\n (:identifiers (:sid . :s341.4) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003130@unknown@formal@none@1@S@DLCL represent a heterogeneous group of neoplasms which are treated homogeneously despite the fact that only 50% of patients experience long-term disease-free survival (Schneider et al. 1990).@(((:tag . "NNP") (:stem . "DLCL") (:form . "DLCL") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "neoplasm") (:form . "neoplasms") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "RB") (:stem . "homogeneously") (:form . "homogeneously")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "VBP") (:stem . "experience") (:form . "experience") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "JJ") (:stem . "disease-free") (:form . "disease-free") (:end . 158)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 167)\n  (:start . 159) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Schneider") (:form . "Schneider") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1990") (:form . "1990") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s341.6) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003131@unknown@formal@none@1@S@The fact that BCL-6 rearrangements identify biologically and clinically distinct subsets of DLCL suggests that these lesions may be useful as markers in selection of differential therapeutic strategies based on different risk groups.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 34) (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 56)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DLCL") (:form . "DLCL") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 162)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 178)\n  (:start . 166) (:id . 67))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 190)\n  (:start . 179) (:id . 68))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 201)\n  (:start . 191) (:id . 69))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 207)\n  (:start . 202) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 210) (:start . 208)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 220)\n  (:start . 211) (:id . 72))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 225) (:start . 221)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 232)\n  (:start . 226) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x341.7.1) (:span 125 128))\n  ((:id . :x341.7.2) (:span 97 105)))\n (:hscopes ((:id . :x341.7.1) (:span 125 232))\n  ((:id . :x341.7.2) (:span 97 232)))\n (:identifiers (:sid . :s341.7) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003132@unknown@formal@none@1@S@Furthermore, the BCL-6 rearrangements can be used to identify and monitor the malignant clone with sensitive PCR-based techniques.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "monitor") (:form . "monitor") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "pcr-based") (:form . "PCR-based") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "technique") (:form . "techniques") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s341.8) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003133@unknown@formal@none@1@S@Since clinical remission has been observed in a significant fraction of DLCL cases, these markers may serve as critical tools for sensitive monitoring of minimal residual disease and early diagnosis of relapse (Gribben et al. 1993).@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "remission") (:form . "remission") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DLCL") (:form . "DLCL") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "tool") (:form . "tools") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "monitoring") (:form . "monitoring") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "JJ") (:stem . "residual") (:form . "residual") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 188)\n  (:start . 183) (:id . 71))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 198)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "relapse") (:form . "relapse") (:end . 209)\n  (:start . 202) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Gribben") (:form . "Gribben") (:end . 218)\n  (:start . 211) (:id . 76))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 221) (:start . 219)\n  (:id . 77))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . "CD") (:stem . "1993") (:form . "1993") (:end . 230) (:start . 226)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 231) (:start . 230)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x341.9.1) (:span 98 101)))\n (:hscopes ((:id . :x341.9.1) (:span 98 209)))\n (:identifiers (:sid . :s341.9) (:did . :|96063079|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003134@unknown@formal@none@1@S@Selective effects of DNA damaging agents on HIV long terminal repeat activation and virus replication in vitro.@(((:tag . "JJ") (:stem . "selective") (:form . "Selective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "damaging") (:form . "damaging") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s342.1) (:did . :|96147310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003135@unknown@formal@none@1@S@Much attention has recently focused on the observation that UV light can activate the long terminal repeat (LTR) of the human immunodeficiency virus (HIV).@(((:tag . "JJ") (:stem . "much") (:form . "Much") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "attention") (:form . "attention") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 142) (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s342.2) (:did . :|96147310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003136@unknown@formal@none@1@S@Although the mechanism of LTR activation remains obscure, several lines of investigation have suggested that it is a result of activation of the NF-kappa B transcription factor ( s ) following signaling events related to generalized DNA damage.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "obscure") (:form . "obscure") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 169) (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 192)\n  (:start . 183) (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 202)\n  (:start . 193) (:id . 74))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 209)\n  (:start . 203) (:id . 75))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 217)\n  (:start . 210) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 220) (:start . 218)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "generalize") (:form . "generalized") (:end . 232)\n  (:start . 221) (:id . 78))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 236) (:start . 233)\n  (:id . 79))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 243)\n  (:start . 237) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x342.3.1) (:span 94 103)))\n (:hscopes ((:id . :x342.3.1) (:span 94 243)))\n (:identifiers (:sid . :s342.3) (:did . :|96147310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003137@unknown@formal@none@1@S@In this report, we present data demonstrating that HIV LTR activation is not a general consequence of cellular DNA damage, but rather a process unique to specific genotoxic stimuli, and that it does not necessarily depend on activation of NF-kappa B.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 45)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 133)\n  (:start . 127) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "JJ") (:stem . "genotoxic") (:form . "genotoxic") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 180)\n  (:start . 173) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 190) (:start . 186)\n  (:id . 75))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 193) (:start . 191)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 198) (:start . 194)\n  (:id . 77))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 202) (:start . 199)\n  (:id . 78))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 214)\n  (:start . 203) (:id . 79))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 221)\n  (:start . 215) (:id . 80))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 224) (:start . 222)\n  (:id . 81))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 235)\n  (:start . 225) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 247)\n  (:start . 239) (:id . 84))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 249) (:start . 248)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x342.4.1) (:span 73 76)))\n (:nscopes ((:id . :x342.4.1) (:span 73 121)))\n (:identifiers (:sid . :s342.4) (:did . :|96147310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003138@unknown@formal@none@1@S@Furthermore, we demonstrate that several of these agents can significantly increase HIV replication and accelerate CD4-positive lymphocyte cytotoxicity in vitro.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 74) (:start . 61) (:id . 52))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VB") (:stem . "accelerate") (:form . "accelerate") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "cd4-positive") (:form . "CD4-positive") (:end . 127)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 151)\n  (:start . 139) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 160)\n  (:start . 155) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s342.5) (:did . :|96147310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003140@unknown@formal@none@1@S@Characterization and purification of a protein kinase C substrate in human B cells.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 43))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s343.1) (:did . :|96173754|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003141@unknown@formal@none@1@S@Identification as lymphocyte-specific protein 1 (LSP1).@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 37) (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 47) (:start . 46)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lsp1") (:form . "LSP1") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s343.2) (:did . :|96173754|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003142@unknown@formal@none@1@S@Incubation of B-chronic lymphocytic leukemia (B-CLL) cells with phorbol esters resulted in the phosphorylation of two major PKC substrates, MARCKS (myristoylated, alanine-rich C kinase substrate) and MRP (MARCKS-related protein), and of a third protein, with an apparent m.w. of 60,000 that was the most prominent protein kinase C substrate in these cells.@(((:tag . "NNP") (:stem . "Incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "b-chronic") (:form . "B-chronic") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . 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"C") (:end . 330) (:start . 329)\n  (:id . 99))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 340)\n  (:start . 331) (:id . 100))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 343) (:start . 341)\n  (:id . 101))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 349)\n  (:start . 344) (:id . 102))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 355)\n  (:start . 350) (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 356) (:start . 355)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s343.3) (:did . :|96173754|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003143@unknown@formal@none@1@S@p60 phosphorylation was time and PMA dose dependent, and was induced by cell-permeable diacylglycerol, but not by inactive phorbol esters.@(((:tag . "NN") (:stem . "p60") (:form . "p60") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cell-permeable") (:form . "cell-permeable")\n  (:end . 86) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "diacylglycerol") (:form . "diacylglycerol")\n  (:end . 101) (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x343.4.1) (:span 107 110)))\n (:nscopes ((:id . :x343.4.1) (:span 107 137)))\n (:identifiers (:sid . :s343.4) (:did . :|96173754|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003144@unknown@formal@none@1@S@Two-dimensional electrophoretic analysis of the protein phosphorylation pattern from the B cell line CESS demonstrated the identity between the p60 protein expressed in this cell line and that expressed in B-CLL cells.@(((:tag . "JJ") (:stem . "two-dimensional") (:form . "Two-dimensional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 31) (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 40)\n  (:start . 32) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 71) (:start . 56) (:id . 48))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 79)\n  (:start . 72) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cess") (:form . "CESS") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 118)\n  (:start . 106) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 131)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 139)\n  (:start . 132) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p60") (:form . "p60") (:end . 147) (:start . 144)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 165)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 173) (:start . 169)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 178) (:start . 174)\n  (:id . 66))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 183) (:start . 179)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 68))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 202)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 211)\n  (:start . 206) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 217)\n  (:start . 212) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s343.5) (:did . :|96173754|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003145@unknown@formal@none@1@S@p60 was purified from CESS cells and peptide microsequencing of this protein revealed that it was lymphocyte-specific protein 1 (LSP1), that is here characterized as the most prominent protein kinase C substrate in B cells.@(((:tag . "NN") (:stem . "p60") (:form . "p60") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cess") (:form . "CESS") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "microsequencing") (:form . "microsequencing")\n  (:end . 60) (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 117) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LSP1") (:form . "LSP1") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 162) (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 184)\n  (:start . 175) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 192)\n  (:start . 185) (:id . 73))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 199)\n  (:start . 193) (:id . 74))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 201) (:start . 200)\n  (:id . 75))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 222)\n  (:start . 217) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s343.6) (:did . :|96173754|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003146@unknown@formal@none@1@S@Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s344.1) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003147@unknown@formal@none@1@S@IL-4 and IL-10 inhibit the cytokine production and mRNA expression by monocytes/macrophages.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 91) (:start . 70) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s344.2) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003148@unknown@formal@none@1@S@To investigate the molecular mechanism of the inhibitory effect on transcriptional or post-transcriptional regulation of IL-6 gene expression by IL-4 and IL-10, we studied IL-6 production, expression level of IL-6 mRNA, IL-6 promoter activity, transcriptional activity of NF-kappaB and NF-IL-6, and IL-6 mRNA stability in human monocytic cell lines, THP-1 and U937, stimulated by PMA and LPS in the absence or the presence of IL-4 or IL-10.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . 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"NN") (:stem . "absence") (:form . "absence") (:end . 406)\n  (:start . 399) (:id . 108))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 409) (:start . 407)\n  (:id . 109))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 413) (:start . 410)\n  (:id . 110))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 422)\n  (:start . 414) (:id . 111))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 425) (:start . 423)\n  (:id . 112))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 430) (:start . 426)\n  (:id . 113))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 433) (:start . 431)\n  (:id . 114))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 439)\n  (:start . 434) (:id . 115))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 440) (:start . 439)\n  (:id . 116)))@@@1@75@((:identifiers (:sid . :s344.3) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003150@unknown@formal@none@1@S@In chloramphenicol acetyltransferase assays, utilizing the transient transfection of a chloramphenicol acetyltransferase reporter plasmid containing the IL-6 gene promoter, IL-4, but not IL-10, suppressed the transcriptional activity of the IL-6 gene promoter stimulated by PMA and LPS.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 36) (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "utilize") (:form . "utilizing") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 68)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 81)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 102) (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 120) (:start . 103) (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 129)\n  (:start . 121) (:id . 55))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 137)\n  (:start . 130) (:id . 56))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 148)\n  (:start . 138) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 157) (:start . 153)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 162) (:start . 158)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 171)\n  (:start . 163) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 177) (:start . 173)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 182) (:start . 179)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 186) (:start . 183)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 192)\n  (:start . 187) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 204)\n  (:start . 194) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 224) (:start . 209) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 233)\n  (:start . 225) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 240) (:start . 237)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 245) (:start . 241)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 250) (:start . 246)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 259)\n  (:start . 251) (:id . 77))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 270)\n  (:start . 260) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 273) (:start . 271)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 277) (:start . 274)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 281) (:start . 278)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 285) (:start . 282)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x344.5.1) (:span 183 186)))\n (:nscopes ((:id . :x344.5.1) (:span 183 192)))\n (:identifiers (:sid . :s344.5) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003151@unknown@formal@none@1@S@Electrophoretic mobility shift assays showed that IL-4, but not IL-10, inhibited nuclear NF-kappaB activity, and that IL-4 and IL-10 did not affect NF-IL-6 activity.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 44) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "nf-il-6") (:form . "NF-IL-6") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 164)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x344.6.1) (:span 137 140))\n  ((:id . :x344.6.2) (:span 60 63)))\n (:nscopes ((:id . :x344.6.1) (:span 137 164))\n  ((:id . :x344.6.2) (:span 60 69)))\n (:identifiers (:sid . :s344.6) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003152@unknown@formal@none@1@S@On the other hand, IL-10 enhanced the degradation of IL-6 mRNA in a mRNA stability assay.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 82)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s344.7) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003153@unknown@formal@none@1@S@These results suggest that IL-4 may inhibit the transcription of the IL-6 gene by affecting NF-kappaB binding activity, while IL-10 may inhibit the IL-6 mRNA levels post-transcriptionally, without suppressing promoter activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "RB") (:stem . "post-transcriptionally")\n  (:form . "post-transcriptionally") (:end . 187) (:start . 165) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 70))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 196)\n  (:start . 189) (:id . 71))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 208)\n  (:start . 197) (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 217)\n  (:start . 209) (:id . 73))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 226)\n  (:start . 218) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x344.8.2) (:span 132 135)) ((:id . :x344.8.3) (:span 32 35))\n  ((:id . :x344.8.4) (:span 14 21)))\n (:ncues ((:id . :x344.8.1) (:span 189 196)))\n (:hscopes ((:id . :x344.8.2) (:span 132 226))\n  ((:id . :x344.8.3) (:span 32 118)) ((:id . :x344.8.4) (:span 14 226)))\n (:nscopes ((:id . :x344.8.1) (:span 189 226)))\n (:identifiers (:sid . :s344.8) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003154@unknown@formal@none@1@S@Therefore, we conclude that IL-4 and IL-10 inhibit IL-6 production by different mechanisms in human monocytic cell lines.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s344.9) (:did . :|96180219|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003155@unknown@formal@none@1@S@IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines:@(((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "JAK2") (:form . "JAK2") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "colon") (:form . "colon") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s345.1) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003156@unknown@formal@none@1@S@similarities between IL-4 and IL-13 signaling.@(((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s345.2) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003157@unknown@formal@none@1@S@We have recently reported that IL-13R may share a component with IL-4R.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-13R") (:form . "IL-13R") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "share") (:form . "share") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x345.3.1) (:span 38 41)))\n (:hscopes ((:id . :x345.3.1) (:span 38 70)))\n (:identifiers (:sid . :s345.3) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003158@unknown@formal@none@1@S@Here we report that both IL-4 and IL-13 share signaling events in human colon carcinoma cell lines (HT-29 and WiDr).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "share") (:form . "share") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "colon") (:form . "colon") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HT-29") (:form . "HT-29") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "WiDr") (:form . "WiDr") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s345.4) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003160@unknown@formal@none@1@S@We show that JAK2 kinase is rapidly phosphorylated and activated in response to IL-13.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "JAK2") (:form . "JAK2") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 50) (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s345.6) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003161@unknown@formal@none@1@S@Within 1 min of activation, JAK2 was phosphorylated, and peaked in 10 min.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "JAK2") (:form . "JAK2") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 51) (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "peak") (:form . "peaked") (:end . 63) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s345.7) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003162@unknown@formal@none@1@S@In addition, IL-13 phosphorylated insulin response substrate-1, IL-4R p140, JAK1, and Tyk2, but not JAK3 kinase.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 33) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "substrate-1") (:form . "substrate-1") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p140") (:form . "p140") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "JAK1") (:form . "JAK1") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tyk2") (:form . "Tyk2") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 111)\n  (:start . 105) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x345.8.1) (:span 96 99)))\n (:nscopes ((:id . :x345.8.1) (:span 96 111)))\n (:identifiers (:sid . :s345.8) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003163@unknown@formal@none@1@S@IL-4 also stimulated all three kinases and substrates, but unlike in immune cells, IL-4 did not involve JAK3 activation for its signaling in colon cancer cell lines.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "colon") (:form . "colon") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x345.9.1) (:span 92 95)))\n (:nscopes ((:id . :x345.9.1) (:span 92 164)))\n (:identifiers (:sid . :s345.9) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003164@unknown@formal@none@1@S@Furthermore, JAK2 associated with the IL-4R p140 before and after stimulation with IL-13.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p140") (:form . "p140") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s345.10) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003165@unknown@formal@none@1@S@Both IL-13 and IL-4 induced phosphorylation of IL-4 STAT (STAT6) but not STAT1, STAT3, or STAT5.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 43) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 95) (:start . 90)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x345.11.1) (:span 69 72)))\n (:nscopes ((:id . :x345.11.1) (:span 69 95)))\n (:identifiers (:sid . :s345.11) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003166@unknown@formal@none@1@S@125I-IL-13 did not bind to colon cancer cell lines, but unlabeled IL-13 competed for the binding of 125I-IL-4.@(((:tag . "NN") (:stem . "125i-il-13") (:form . "125I-IL-13") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "colon") (:form . "colon") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unlabeled") (:form . "unlabeled") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "compete") (:form . "competed") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "125i-il-4") (:form . "125I-IL-4") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x345.12.1) (:span 15 18)))\n (:nscopes ((:id . :x345.12.1) (:span 15 50)))\n (:identifiers (:sid . :s345.12) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003167@unknown@formal@none@1@S@Our data suggest that IL-13 utilizes IL-4R and its signaling pathway, and JAK2 may play an important role in the function of IL-4R and IL-13R in colon cancer cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "utilize") (:form . "utilizes") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 130)\n  (:start . 125) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IL-13R") (:form . "IL-13R") (:end . 141)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "colon") (:form . "colon") (:end . 150)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 157)\n  (:start . 151) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 163)\n  (:start . 158) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x345.13.1) (:span 79 82)) ((:id . :x345.13.2) (:span 9 16)))\n (:hscopes ((:id . :x345.13.1) (:span 79 163))\n  ((:id . :x345.13.2) (:span 9 163)))\n (:identifiers (:sid . :s345.13) (:did . :|96183254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003168@unknown@formal@none@1@S@Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-10") (:form . "interleukin-10")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Cryptococcus") (:form . "Cryptococcus") (:end . 94)\n  (:start . 82) (:id . 53))\n ((:tag . "NNS") (:stem . "neoforman") (:form . "neoformans") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Candida") (:form . "Candida") (:end . 114)\n  (:start . 107) (:id . 56))\n ((:tag . "NNP") (:stem . "albicans") (:form . "albicans") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 147) (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s346.1) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003170@unknown@formal@none@1@S@We compared the effects of the deactivating cytokine interleukin 10 (IL-10) on human peripheral blood mononuclear cell (PBMC) responses to lipopolysaccharide (LPS), Cryptococcus neoformans, and Candida albicans.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "deactivate") (:form . "deactivating") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 157) (:start . 139) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Cryptococcus") (:form . "Cryptococcus")\n  (:end . 177) (:start . 165) (:id . 71))\n ((:tag . "NNS") (:stem . "neoforman") (:form . "neoformans") (:end . 188)\n  (:start . 178) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Candida") (:form . "Candida") (:end . 201)\n  (:start . 194) (:id . 75))\n ((:tag . "NNP") (:stem . "albicans") (:form . "albicans") (:end . 210)\n  (:start . 202) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s346.3) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003171@unknown@formal@none@1@S@IL-10 effected dose-dependent inhibition of tumor necrosis factor alpha (TNF-alpha) release in PBMC stimulated by LPS and C. neoformans, with significant inhibition seen with 0.1 U/ml and greater than 90% inhibition noted with 10 U/ml.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "effect") (:form . "effected") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 29) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 40)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 153)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 164)\n  (:start . 154) (:id . 66))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 195)\n  (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 215)\n  (:start . 205) (:id . 76))\n ((:tag . "VBD") (:stem . "note") (:form . "noted") (:end . 221)\n  (:start . 216) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 226) (:start . 222)\n  (:id . 78))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 229) (:start . 227)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 234) (:start . 230)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s346.4) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003172@unknown@formal@none@1@S@In contrast, even at doses as high as 100 U/ml, IL-10 inhibited TNF-alpha release in response to C. albicans by only 50%.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 53) (:start . 48)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 63)\n  (:start . 54) (:id . 55))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 73)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "FW") (:stem . "albicans") (:form . "albicans") (:end . 108)\n  (:start . 100) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 120) (:start . 119)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s346.5) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003173@unknown@formal@none@1@S@IL-10 profoundly inhibited release of IL-1beta from PBMC stimulated by all three stimuli.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "profoundly") (:form . "profoundly") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s346.6) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003174@unknown@formal@none@1@S@TNF-alpha mRNA and release was inhibited even if IL-10 was added up to 8 h after cryptococcal stimulation.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cryptococcal") (:form . "cryptococcal") (:end . 93)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 105)\n  (:start . 94) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s346.7) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003175@unknown@formal@none@1@S@In contrast, inhibition of IL-1 beta mRNA was of lesser magnitude and occurred only when IL-10 was added within 2 h of cryptococcal stimulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 55) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cryptococcal") (:form . "cryptococcal") (:end . 131)\n  (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 143)\n  (:start . 132) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s346.8) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003176@unknown@formal@none@1@S@IL-10 inhibited translocation of NF-kappaB in response to LPS but not the fungal stimuli.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fungal") (:form . "fungal") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x346.9.1) (:span 66 69)))\n (:nscopes ((:id . :x346.9.1) (:span 66 88)))\n (:identifiers (:sid . :s346.9) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003177@unknown@formal@none@1@S@All three stimuli induced IL-10 production in PBMC, although over 10-fold less IL-10 was released in response to C. neoformans compared with LPS and C. albicans.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "albicans") (:form . "albicans") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s346.10) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003178@unknown@formal@none@1@S@Thus, while IL-10 has deactivating effects on PBMC responses to all three stimuli, disparate stimulus- and response-specific patterns of deactivation are seen.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "deactivate") (:form . "deactivating") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "disparate") (:form . "disparate") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "stimulus-") (:form . "stimulus-") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "response-specific") (:form . "response-specific")\n  (:end . 124) (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "deactivation") (:form . "deactivation") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s346.11) (:did . :|96186497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003180@unknown@formal@none@1@S@Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "a-resistant") (:form . "A-resistant") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s347.1) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003181@unknown@formal@none@1@S@The mechanism of action of the immunosuppressive drug cyclosporin A (CsA) is the inactivation of the Ca2+/calmodulin-dependent serine-threonine phosphatase calcineurin by the drug-immunophilin complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 48) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 93)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 126) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "serine-threonine") (:form . "serine-threonine")\n  (:end . 143) (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 155)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 167)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 170) (:start . 168)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 65))\n ((:tag . "NN") (:stem . "drug-immunophilin") (:form . "drug-immunophilin")\n  (:end . 192) (:start . 175) (:id . 66))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 200)\n  (:start . 193) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s347.2) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003182@unknown@formal@none@1@S@Inactive calcineurin is unable to activate the nuclear factor of activated T cells (NFAT), a transcription factor required for expression of the interleukin 2 (IL-2) gene.@(((:tag . "JJ") (:stem . "inactive") (:form . "Inactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 156)\n  (:start . 145) (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x347.3.1) (:span 24 30)))\n (:nscopes ((:id . :x347.3.1) (:span 24 89)))\n (:identifiers (:sid . :s347.3) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003183@unknown@formal@none@1@S@IL-2 production by CsA-treated cells is therefore dramatically reduced.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "csa-treated") (:form . "CsA-treated") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 62)\n  (:start . 50) (:id . 49))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s347.4) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003184@unknown@formal@none@1@S@We demonstrate here, however, that NFAT can be activated, and significant levels of IL-2 can be produced by the CsA-resistant CD28-signaling pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 73)\n  (:start . 62) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "csa-resistant") (:form . "CsA-resistant")\n  (:end . 125) (:start . 112) (:id . 64))\n ((:tag . "JJ") (:stem . "cd28-signaling") (:form . "CD28-signaling")\n  (:end . 140) (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s347.5) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003185@unknown@formal@none@1@S@In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate ( PMA ) /alpha-CD28 stimulation, and this activation was resistant to CsA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "multicopy") (:form . "multicopy") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "nfat-") (:form . "NFAT-") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter-beta-galactosidase")\n  (:form . "promoter-beta-galactosidase") (:end . 91) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 100)\n  (:start . 92) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 116)\n  (:start . 106) (:id . 55))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 122)\n  (:start . 117) (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 146)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 159)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 170)\n  (:start . 160) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 176) (:start . 173)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 65))\n ((:tag . "NN") (:stem . "/alpha-cd28") (:form . "/alpha-CD28") (:end . 190)\n  (:start . 179) (:id . 66))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 202)\n  (:start . 191) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 212) (:start . 208)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 223)\n  (:start . 213) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 227) (:start . 224)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 237)\n  (:start . 228) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 240) (:start . 238)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 244) (:start . 241)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s347.6) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003186@unknown@formal@none@1@S@Electrophoretic mobility shift assay showed the induction of a CsA-resistant NFAT complex in the nuclear extracts of peripheral blood T cells stimulated with PMA plus alphaCD28.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 43) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "csa-resistant") (:form . "CsA-resistant")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "alphacd28") (:form . "alphaCD28") (:end . 176)\n  (:start . 167) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s347.7) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003187@unknown@formal@none@1@S@Peripheral blood T cells stimulated with PMA/alphaCD28 produced IL-2 in the presence of CsA.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pma/alphacd28") (:form . "PMA/alphaCD28")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s347.8) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003188@unknown@formal@none@1@S@Collectively, these data suggest that NFAT can be activated and IL-2 can be produced in a calcineurin independent manner.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 101)\n  (:start . 90) (:id . 59))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 113)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x347.9.1) (:span 69 72)) ((:id . :x347.9.2) (:span 43 46))\n  ((:id . :x347.9.3) (:span 25 32)))\n (:hscopes ((:id . :x347.9.1) (:span 64 120))\n  ((:id . :x347.9.2) (:span 38 59)) ((:id . :x347.9.3) (:span 25 120)))\n (:identifiers (:sid . :s347.9) (:did . :|96205960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003190@unknown@formal@none@1@S@Although transcriptional factors AP-1 and nuclear factor of activated T cells (NF-AT) are important for the normal induction of IL-2, it is unknown if the age-related decline in IL-2 production by activated human T cells may be associated with aberrancies in transcriptional regulatory proteins.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . 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5003191@unknown@formal@none@1@S@In the current studies, IL-2 production by T cells from elderly (mean 78 years) and young (mean 37 years) humans was measured in cultures stimulated with PHA, PHA plus PMA, crosslinked anti-CD3 mAB OKT3 plus PMA, or PMA plus ionomycin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 95) (:start . 91)\n  (:id . 62))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 98) (:start . 96)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 104) (:start . 99)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 112)\n  (:start . 106) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 125)\n  (:start . 117) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 137)\n  (:start . 129) (:id . 70))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 148)\n  (:start . 138) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 157) (:start . 154)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 162) (:start . 159)\n  (:id . 75))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 167) (:start . 163)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 171) (:start . 168)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "crosslinke") (:form . "crosslinked") (:end . 184)\n  (:start . 173) (:id . 79))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 193)\n  (:start . 185) (:id . 80))\n ((:tag . "NNP") (:stem . "mAB") (:form . "mAB") (:end . 197) (:start . 194)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 202) (:start . 198)\n  (:id . 82))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 207) (:start . 203)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 211) (:start . 208)\n  (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 85))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 215) (:start . 213)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 219) (:start . 216)\n  (:id . 87))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 224) (:start . 220)\n  (:id . 88))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 234)\n  (:start . 225) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s348.3) (:did . :|96211859|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003192@unknown@formal@none@1@S@Substantial decreases of IL-2 production were observed for cell cultures from 7 of 12 elderly individuals in response to the different stimuli, whereas the levels of IL-2 produced by stimulated T cells from other elderly individuals were equivalent to those observed for stimulated T cells of young subjects.@(((:tag . "JJ") (:stem . "substantial") (:form . "Substantial") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . 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5003193@unknown@formal@none@1@S@Analyses of nuclear extracts by electrophoretic DNA mobility shift assays showed that decreased IL-2 production by stimulated T cells of elderly individuals was closely associated with impairments in the activation of both AP-1 and NF-AT.@(((:tag . "NNS") (:stem . "analysis") (:form . "Analyses") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 47) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 80) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 156)\n  (:start . 145) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 168)\n  (:start . 161) (:id . 65))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 179)\n  (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "impairment") (:form . "impairments") (:end . 196)\n  (:start . 185) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 214)\n  (:start . 204) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 222) (:start . 218)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 237)\n  (:start . 232) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s348.5) (:did . :|96211859|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003194@unknown@formal@none@1@S@By contrast, T cells from elderly subjects with normal levels of IL-2 production exhibited normal activation of AP-1 and NF-AT.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s348.6) (:did . :|96211859|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5003196@unknown@formal@none@1@S@The resting and stimulated levels of NF kappa B were reduced in T cells from certain elderly individuals;@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "resting") (:form . "resting") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 104)\n  (:start . 93) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s348.8) (:did . :|96211859|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5003198@unknown@formal@none@1@S@Thus, these results show that age-related impairments in the activation of AP-1 and NF-AT are closely associated with decreased expression of IL-2 and further suggest that aberrancies in the signaling pathways important for the induction of transcriptionally active c-Fos/c-Jun AP-1 may contribute to the impaired activation of NF-AT.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "age-related") (:form . 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"activation") (:end . 324)\n  (:start . 314) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 327) (:start . 325)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 333)\n  (:start . 328) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 334) (:start . 333)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x348.10.1) (:span 283 286))\n  ((:id . :x348.10.2) (:span 159 166)))\n (:hscopes ((:id . :x348.10.1) (:span 283 333))\n  ((:id . :x348.10.2) (:span 159 333)))\n (:identifiers (:sid . :s348.10) (:did . :|96211859|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003200@unknown@formal@none@1@S@Tissue specific regulation of gene expression by transcription factors is a fascinating new field in molecular immunology.@(((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fascinating") (:form . "fascinating") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "immunology") (:form . "immunology") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s349.2) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003201@unknown@formal@none@1@S@This review summarizes data on specific regulation of promoters and enhancers by nuclear trans-acting factors in lymphocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "summarize") (:form . "summarizes") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "trans-acting") (:form . "trans-acting") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s349.3) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003202@unknown@formal@none@1@S@The structural classes of transcription factors are described and basic methods for detection and analysis of transcription factors are detailed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "detail") (:form . "detailed") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s349.4) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003203@unknown@formal@none@1@S@Furthermore, the most important trans-acting factors of T and B lymphocytes (e.g. NF-kB, NF-AT and STAT families) and their functional importance are described.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "trans-acting") (:form . "trans-acting") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 75)\n  (:start . 64) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 134)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 159)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s349.5) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003204@unknown@formal@none@1@S@Several methods for specific down-regulation of transcription factors are shown that may be relevant to treatment of human disease.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 44) (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 69)\n  (:start . 62) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x349.6.1) (:span 85 88)))\n (:hscopes ((:id . :x349.6.1) (:span 85 130)))\n (:identifiers (:sid . :s349.6) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003205@unknown@formal@none@1@S@The data are discussed with regard to their potential clinical relevance for gastroenterology.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 43)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gastroenterology") (:form . "gastroenterology")\n  (:end . 93) (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s349.7) (:did . :|96230713|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003206@unknown@formal@none@1@S@Modulation of the expression of the IFN-gamma receptor beta-chain controls responsiveness to IFN-gamma in human peripheral blood T cells.@(((:tag . "NN") (:stem . "modulation") (:form . "Modulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 89) (:start . 75) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 128)\n  (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s350.1) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003207@unknown@formal@none@1@S@IFN-gamma has potent antiproliferative and apoptotic effects in T cells that are important in determining T cell development and polarized differentiation.@(((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "antiproliferative") (:form . "antiproliferative")\n  (:end . 38) (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "polarize") (:form . "polarized") (:end . 138)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 154) (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s350.2) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003208@unknown@formal@none@1@S@Therefore, any event that enables T cells to become less responsive to IFN-gamma may potentially alter immune responsiveness to Ag.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "enable") (:form . "enables") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 96)\n  (:start . 85) (:id . 57))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 124) (:start . 110) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x350.3.1) (:span 85 96)) ((:id . :x350.3.2) (:span 81 84)))\n (:hscopes ((:id . :x350.3.1) (:span 85 130))\n  ((:id . :x350.3.2) (:span 81 130)))\n (:identifiers (:sid . :s350.3) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003210@unknown@formal@none@1@S@This nonresponsiveness occurs because of a lack of expression of the beta-chain (accessory factor) of the IFN-gamma receptor, while at the same time maintaining IFN-gamma receptor alpha-chain expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nonresponsiveness") (:form . "nonresponsiveness")\n  (:end . 22) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 29)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 160)\n  (:start . 149) (:id . 68))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 170)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 202)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x350.5.1) (:span 43 47)))\n (:nscopes ((:id . :x350.5.1) (:span 43 124)))\n (:identifiers (:sid . :s350.5) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003211@unknown@formal@none@1@S@Expression of the beta-chain can be restored by secondary TCR ligation or PMA treatment.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "restore") (:form . "restored") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s350.6) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003212@unknown@formal@none@1@S@T cell blasts treated with PMA are now responsive to IFN-gamma.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s350.7) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003213@unknown@formal@none@1@S@When freshly isolated, highly enriched (> 98%) T cells are examined for IFN-gamma responsiveness;@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "98") (:form . "98") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 67)\n  (:start . 59) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 81)\n  (:start . 72) (:id . 58))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 96) (:start . 82) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 97) (:start . 96)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s350.8) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003214@unknown@formal@none@1@S@these cells can respond to IFN-gamma and express beta-chain.@(((:tag . "DT") (:stem . "these") (:form . "these") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s350.9) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003215@unknown@formal@none@1@S@Therefore, as T cells progress from primary TCR activation through IL-2-dependent proliferation, followed by secondary TCR stimulation, their responsiveness to IFN-gamma varies, and this may affect their ability to participate in an ongoing immune response.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "progress") (:form . "progress") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "il-2-dependent") (:form . "IL-2-dependent")\n  (:end . 81) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 134)\n  (:start . 123) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 156) (:start . 142) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . "VBZ") (:stem . "vary") (:form . "varies") (:end . 176)\n  (:start . 170) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 186) (:start . 182)\n  (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 190) (:start . 187)\n  (:id . 70))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 197)\n  (:start . 191) (:id . 71))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 203)\n  (:start . 198) (:id . 72))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 211)\n  (:start . 204) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 214) (:start . 212)\n  (:id . 74))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 226)\n  (:start . 215) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 232) (:start . 230)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "ongoing") (:form . "ongoing") (:end . 240)\n  (:start . 233) (:id . 78))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 247)\n  (:start . 241) (:id . 79))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 256)\n  (:start . 248) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x350.10.1) (:span 187 190)))\n (:hscopes ((:id . :x350.10.1) (:span 187 256)))\n (:identifiers (:sid . :s350.10) (:did . :|96247631|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003216@unknown@formal@none@1@S@Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT1") (:form . "NFAT1") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s351.1) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003217@unknown@formal@none@1@S@Transcription factors of the NFAT family play a key role in the transcription of cytokine genes and other genes during the immune response.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s351.2) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003218@unknown@formal@none@1@S@We have identified two new isoforms of the transcription factor NFAT1 (previously termed NFATp) that are the predominant isoforms expressed in murine and human T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 88) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s351.3) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003220@unknown@formal@none@1@S@Transactivation by recombinant NFAT1 in Jurkat T cells requires dual stimulation with ionomycin and phorbol 12-myristate 13-acetate;@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 120)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 131)\n  (:start . 121) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 132) (:start . 131)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s351.5) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003221@unknown@formal@none@1@S@this activity is potentiated by coexpression of constitutively active calcineurin and is inhibited by CsA.@(((:tag . "DT") (:stem . "this") (:form . "this") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "potentiate") (:form . "potentiated") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 62) (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 81)\n  (:start . 70) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s351.6) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003222@unknown@formal@none@1@S@Immunocytochemical analysis indicates that recombinant NFAT1 localizes in the cytoplasm of transiently transfected T cells and translocates into the nucleus in a CsA-sensitive manner following ionomycin stimulation.@(((:tag . "JJ") (:stem . "immunocytochemical") (:form . "Immunocytochemical")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 37)\n  (:start . 28) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 54)\n  (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 60) (:start . 55)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "localize") (:form . "localizes") (:end . 70)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 102)\n  (:start . 91) (:id . 53))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 114)\n  (:start . 103) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "translocate") (:form . "translocates") (:end . 139)\n  (:start . 127) (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 144) (:start . 140)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 156)\n  (:start . 149) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 175) (:start . 162) (:id . 64))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 182)\n  (:start . 176) (:id . 65))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 192)\n  (:start . 183) (:id . 66))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 202)\n  (:start . 193) (:id . 67))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 214)\n  (:start . 203) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x351.7.1) (:span 28 42)))\n (:hscopes ((:id . :x351.7.1) (:span 28 214)))\n (:identifiers (:sid . :s351.7) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003223@unknown@formal@none@1@S@When expressed in COS cells, however, NFAT1 is capable of transactivation, but it is not regulated correctly:@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "COS") (:form . "COS") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT1") (:form . "NFAT1") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 73) (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 98)\n  (:start . 89) (:id . 60))\n ((:tag . "RB") (:stem . "correctly") (:form . "correctly") (:end . 108)\n  (:start . 99) (:id . 61))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 109) (:start . 108)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x351.8.1) (:span 85 88)))\n (:nscopes ((:id . :x351.8.1) (:span 79 108)))\n (:identifiers (:sid . :s351.8) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003224@unknown@formal@none@1@S@its subcellular localization and transcriptional function are not affected by stimulation of the COS cells with ionomycin and phorbol 12-myristate 13-acetate.@(((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 48) (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 57)\n  (:start . 49) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 89)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "COS") (:form . "COS") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 146)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 157)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x351.9.1) (:span 62 65)))\n (:nscopes ((:id . :x351.9.1) (:span 0 157)))\n (:identifiers (:sid . :s351.9) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003225@unknown@formal@none@1@S@Recombinant NFAT1 can mediate transcription of the interleukin-2, interleukin-4, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor promoters in T cells, suggesting that NFAT1 contributes to the CsA-sensitive transcription of these genes during the immune response.@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 136) (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 155) (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 162)\n  (:start . 156) (:id . 61))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 172)\n  (:start . 163) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 177) (:start . 176)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 195)\n  (:start . 185) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 200) (:start . 196)\n  (:id . 68))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 206)\n  (:start . 201) (:id . 69))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 218)\n  (:start . 207) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 221) (:start . 219)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 239) (:start . 226) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 253) (:start . 240) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 256) (:start . 254)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 262)\n  (:start . 257) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 268)\n  (:start . 263) (:id . 77))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 275)\n  (:start . 269) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 279) (:start . 276)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 286)\n  (:start . 280) (:id . 80))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 295)\n  (:start . 287) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x351.10.1) (:span 185 195)))\n (:hscopes ((:id . :x351.10.1) (:span 185 295)))\n (:identifiers (:sid . :s351.10) (:did . :|96251346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003226@unknown@formal@none@1@S@Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "VBP") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 92) (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 104)\n  (:start . 97) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 114)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 127)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s352.1) (:did . :|96256807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003227@unknown@formal@none@1@S@B-cell immortalization by Epstein-Barr virus (EBV) is dependent on permanent control of the cellular processes which normally regulate cell division and apoptosis, functions possessed by p53 in a number of normal cell types.@(((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 22) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 44) (:start . 39)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "division") (:form . "division") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 162)\n  (:start . 153) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "VBN") (:stem . "possess") (:form . "possessed") (:end . 183)\n  (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 190) (:start . 187)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 195) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 202)\n  (:start . 196) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 212)\n  (:start . 206) (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 217) (:start . 213)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 223)\n  (:start . 218) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s352.2) (:did . :|96256807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003228@unknown@formal@none@1@S@In studies initiated to evaluate relationships between EBV latent genes and p53, p53 levels were found to increase approximately 10-fold 4 to 5 days after EBV infection of purified resting human B cells;@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "relationship") (:form . "relationships")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 168)\n  (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 180)\n  (:start . 172) (:id . 71))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 203) (:start . 202)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s352.3) (:did . :|96256807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003230@unknown@formal@none@1@S@Latent membrane protein 1 and, to a lesser extent, EBV nuclear antigen 2 mediated the increase in p53 levels via activation of the NF-kappaB transcription factor.@(((:tag . "JJ") (:stem . "latent") (:form . "Latent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 42) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 94)\n  (:start . 86) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 140)\n  (:start . 131) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 154) (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 161)\n  (:start . 155) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s352.5) (:did . :|96256807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003231@unknown@formal@none@1@S@Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "utilization") (:form . "utilization") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "kinase-signal") (:form . "kinase-signal")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 58)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 68)\n  (:start . 59) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 95)\n  (:start . 86) (:id . 51))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 104)\n  (:start . 96) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 132)\n  (:start . 127) (:id . 57))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 140)\n  (:start . 133) (:id . 58))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 147)\n  (:start . 141) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 156) (:start . 154)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 161) (:start . 157)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 168)\n  (:start . 163) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 183)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s353.1) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003232@unknown@formal@none@1@S@IL-2-, IL-12-, and IFN-alpha-mediated signaling pathways were analyzed in primary NK cells and in the NK3.3 cell line.@(((:tag . "NNP") (:stem . "IL-2-") (:form . "IL-2-") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "il-12-") (:form . "IL-12-") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ifn-alpha-mediated") (:form . "IFN-alpha-mediated")\n  (:end . 37) (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nk3.3") (:form . "NK3.3") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s353.2) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003233@unknown@formal@none@1@S@Gel mobility shift and immunoprecipitation analyses revealed that in addition to activating STAT3 (signal transducer and activator of transcription-3) and STAT5, IL-2 induced tyrosine and serine phosphorylation of STAT1 alpha, which formed IFN-gamma-activated sequence-binding complexes by itself and with STAT3.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 42) (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 130)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription-3") (:form . "transcription-3")\n  (:end . 149) (:start . 134) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 183)\n  (:start . 175) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 194)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 210) (:start . 195) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 219)\n  (:start . 214) (:id . 73))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 225)\n  (:start . 220) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 232)\n  (:start . 227) (:id . 76))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 239)\n  (:start . 233) (:id . 77))\n ((:tag . "JJ") (:stem . "ifn-gamma-activated")\n  (:form . "IFN-gamma-activated") (:end . 259) (:start . 240) (:id . 78))\n ((:tag . "JJ") (:stem . "sequence-binding") (:form . "sequence-binding")\n  (:end . 276) (:start . 260) (:id . 79))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 286)\n  (:start . 277) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 289) (:start . 287)\n  (:id . 81))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 296)\n  (:start . 290) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 300) (:start . 297)\n  (:id . 83))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 305) (:start . 301)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 311)\n  (:start . 306) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 312) (:start . 311)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s353.3) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003234@unknown@formal@none@1@S@Although IL-2 and IFN-alpha activated STAT1 alpha and STAT5, IL-2 predominantly activated STAT5, while IFN-alpha predominantly activated STAT1 alpha.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 79) (:start . 66) (:id . 53))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 126) (:start . 113) (:id . 59))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s353.4) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003235@unknown@formal@none@1@S@IL-2 induced less STAT1 alpha activation and IFN-alpha induced greater STAT5 activation in NK3.3 cells compared with preactivated primary NK cells.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nk3.3") (:form . "NK3.3") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "preactivated") (:form . "preactivated") (:end . 129)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 137)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s353.5) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003236@unknown@formal@none@1@S@In NK3.3 cells, IL-2 induced comparable formation of c-fos promoter sis-inducible element IFN-gamma-activated sequence-binding complexes containing STAT3 alone with complexes containing STAT3 and STAT1 alpha, while in preactivated primary NK cells, it preferentially induced complexes containing STAT3 and STAT1 alpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nk3.3") (:form . "NK3.3") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "sis-inducible") (:form . "sis-inducible")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "ifn-gamma-activated")\n  (:form . "IFN-gamma-activated") (:end . 109) (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "sequence-binding") (:form . "sequence-binding")\n  (:end . 126) (:start . 110) (:id . 56))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 136)\n  (:start . 127) (:id . 57))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 147)\n  (:start . 137) (:id . 58))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 153)\n  (:start . 148) (:id . 59))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 159)\n  (:start . 154) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 174)\n  (:start . 165) (:id . 62))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 185)\n  (:start . 175) (:id . 63))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 191)\n  (:start . 186) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 201)\n  (:start . 196) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 207)\n  (:start . 202) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 68))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 214)\n  (:start . 209) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "preactivated") (:form . "preactivated") (:end . 230)\n  (:start . 218) (:id . 71))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 238)\n  (:start . 231) (:id . 72))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 241) (:start . 239)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 247)\n  (:start . 242) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 248) (:start . 247)\n  (:id . 75))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 251) (:start . 249)\n  (:id . 76))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 266) (:start . 252) (:id . 77))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 274)\n  (:start . 267) (:id . 78))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 284)\n  (:start . 275) (:id . 79))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 295)\n  (:start . 285) (:id . 80))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 301)\n  (:start . 296) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 305) (:start . 302)\n  (:id . 82))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 311)\n  (:start . 306) (:id . 83))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 317)\n  (:start . 312) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 318) (:start . 317)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s353.6) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003237@unknown@formal@none@1@S@Thus, signaling in NK3.3 cells is not always identical with that in primary NK cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "nk3.3") (:form . "NK3.3") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "RB") (:stem . "always") (:form . "always") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s353.7) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003238@unknown@formal@none@1@S@In contrast to IL-2 and IFN-alpha, IL-12 induced strong tyrosine phosphorylation of STAT4 and variable weak phosphorylation of STAT3.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 80) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 123) (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s353.8) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003240@unknown@formal@none@1@S@STAT1 alpha activation by IL-12 correlated with increased phosphorylation of serine, but not tyrosine.@(((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 73) (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x353.10.1) (:span 89 92)))\n (:nscopes ((:id . :x353.10.1) (:span 89 101)))\n (:identifiers (:sid . :s353.10) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003241@unknown@formal@none@1@S@Finally, IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while IL-12 induced phosphorylation of JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "JAK1") (:form . "JAK1") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 100) (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tyk2") (:form . "TYK2") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "preactivated") (:form . "preactivated") (:end . 138)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nk3.3") (:form . "NK3.3") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s353.11) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003242@unknown@formal@none@1@S@Differential phosphorylation and consequent differential activation of both separate and overlapping STAT proteins by IL-2, IL-12, and IFN-alpha may provide a molecular basis for the similarities and differences in the actions of these cytokines on NK cells.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 28) (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consequent") (:form . "consequent") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 56)\n  (:start . 44) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 75) (:start . 71)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 84)\n  (:start . 76) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 100)\n  (:start . 89) (:id . 52))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 105) (:start . 101)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 114)\n  (:start . 106) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 122) (:start . 118)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 129)\n  (:start . 124) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 144)\n  (:start . 135) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 156)\n  (:start . 149) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 168)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 174)\n  (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 178) (:start . 175)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 195)\n  (:start . 183) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 211)\n  (:start . 200) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 226)\n  (:start . 219) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 235)\n  (:start . 230) (:id . 76))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 245)\n  (:start . 236) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 248) (:start . 246)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 251) (:start . 249)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 257)\n  (:start . 252) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x353.12.1) (:span 145 148)))\n (:hscopes ((:id . :x353.12.1) (:span 145 257)))\n (:identifiers (:sid . :s353.12) (:did . :|96264681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003243@unknown@formal@none@1@S@Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells.@(((:tag . "JJ") (:stem . "sublethal") (:form . "Sublethal") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 130)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s354.1) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003244@unknown@formal@none@1@S@Sublethal levels of oxidative stress are well known to alter T cell functional responses, but the underlying mechanisms are unknown.@(((:tag . "JJ") (:stem . "sublethal") (:form . "Sublethal") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s354.2) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003245@unknown@formal@none@1@S@The current study examined the effects of oxidative stress on transcriptional activities mediated by c-Fos/c-Jun AP-1 and the nuclear factor of activated T cells (NF-AT).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 77) (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-Fos/c-Jun") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 168)\n  (:start . 163) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s354.3) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003246@unknown@formal@none@1@S@The present results show that Jurkat T cells acutely exposed to micromolar concentrations of H2O2 exhibit substantial increases in AP-1 binding activity and the expression of c-jun but not c-fos mRNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "acutely") (:form . "acutely") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "micromolar") (:form . "micromolar") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 117)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 194)\n  (:start . 189) (:id . 71))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x354.4.1) (:span 185 188)))\n (:nscopes ((:id . :x354.4.1) (:span 185 199)))\n (:identifiers (:sid . :s354.4) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003247@unknown@formal@none@1@S@The preferential induction of c-jun by H2O2 did not represent redox stabilization of mRNA transcripts, and oxidative signals closely resembled PHA/PMA stimulation by effectively transactivating the full length c-jun promoter via the proximal jun1 tumor promoter-responsive element ( TRE ) -like promoter element.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "preferential") (:form . "preferential") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "VBD") (:stem . "resemble") (:form . "resembled") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . "NNP") (:stem . "PHA/PMA") (:form . "PHA/PMA") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 162)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 177)\n  (:start . 166) (:id . 66))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 193) (:start . 178) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 202) (:start . 198)\n  (:id . 69))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 209)\n  (:start . 203) (:id . 70))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 215)\n  (:start . 210) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 224)\n  (:start . 216) (:id . 72))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 228) (:start . 225)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 241)\n  (:start . 233) (:id . 75))\n ((:tag . "NN") (:stem . "jun1") (:form . "jun1") (:end . 246) (:start . 242)\n  (:id . 76))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 252)\n  (:start . 247) (:id . 77))\n ((:tag . "JJ") (:stem . "promoter-responsive")\n  (:form . "promoter-responsive") (:end . 272) (:start . 253) (:id . 78))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 280)\n  (:start . 273) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 282) (:start . 281)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 286) (:start . 283)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 288) (:start . 287)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "-like") (:form . "-like") (:end . 294)\n  (:start . 289) (:id . 83))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 303)\n  (:start . 295) (:id . 84))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 311)\n  (:start . 304) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 312) (:start . 311)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x354.5.1) (:span 48 51)))\n (:nscopes ((:id . :x354.5.1) (:span 48 101)))\n (:identifiers (:sid . :s354.5) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003248@unknown@formal@none@1@S@Similarly, the complexes binding the consensus AP-1 TRE and jun TRE-like motifs in cells exposed to oxidative signals or PHA/PMA were indistinguishable, being composed of c-Fos, c-Jun, and JunD.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tre") (:form . "TRE") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tre-like") (:form . "TRE-like") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PHA/PMA") (:form . "PHA/PMA") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 151) (:start . 134) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 158) (:start . 153)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s354.6) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003250@unknown@formal@none@1@S@Furthermore, sublethal levels of H2O2 actively suppressed the transcriptional activation of NF-AT and IL-2 reporters as well as the expression of IL-2 mRNA in cells stimulated with PHA/PMA.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "sublethal") (:form . "sublethal") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 77) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "reporter") (:form . "reporters") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 175)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PHA/PMA") (:form . "PHA/PMA") (:end . 188)\n  (:start . 181) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s354.8) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003251@unknown@formal@none@1@S@Gel shift analysis revealed that oxidative suppression of NF-AT represented inhibition in the early generation of NFAT complexes rather than the binding of preformed NF-AT complexes.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "represent") (:form . "represented") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "preformed") (:form . "preformed") (:end . 165)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 171)\n  (:start . 166) (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 181)\n  (:start . 172) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x354.9.1) (:span 129 140)))\n (:nscopes ((:id . :x354.9.1) (:span 129 181)))\n (:identifiers (:sid . :s354.9) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003252@unknown@formal@none@1@S@These results suggest that oxidative signals can positively and negatively regulate T cell transcriptional events and that changes in cellular redox can uncouple AP-1 regulation of c-jun from transcriptional up-regulation of IL-2 via NF-AT.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 106) (:start . 91) (:id . 55))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 113)\n  (:start . 107) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "VB") (:stem . "uncouple") (:form . "uncouple") (:end . 161)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 166) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 177)\n  (:start . 167) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 186)\n  (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 207) (:start . 192) (:id . 70))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 221) (:start . 208) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 229) (:start . 225)\n  (:id . 73))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 233) (:start . 230)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 239)\n  (:start . 234) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x354.10.1) (:span 14 21)))\n (:hscopes ((:id . :x354.10.1) (:span 14 239)))\n (:identifiers (:sid . :s354.10) (:did . :|96264685|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003253@unknown@formal@none@1@S@Glucocorticoids and interferon-alpha in the acquired immunodeficiency syndrome.@(((:tag . "NNS") (:stem . "glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interferon-alpha") (:form . "interferon-alpha")\n  (:end . 36) (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 69) (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 78)\n  (:start . 70) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s355.1) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003254@unknown@formal@none@1@S@Some patients with acquired immunodeficiency syndrome (AIDS) develop glucocorticoid resistance characterized by low receptor affinity (Kd) for glucocorticoids in mononuclear , cells and high values of ACTH and cortisol.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 44) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 108) (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 133)\n  (:start . 125) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 158) (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 173)\n  (:start . 162) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 190) (:start . 186)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 197)\n  (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "acth") (:form . "ACTH") (:end . 205) (:start . 201)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 218)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s355.2) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003255@unknown@formal@none@1@S@As glucocorticoids regulate interferon-alpha (IFN alpha) production, we hypothesized that IFN alpha, a cytokine produced predominantly by monocytes in AIDS, should be increased in cortisol-resistant AIDS, attributing the lack of cortisol inhibition to IFN alpha production.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "interferon-alpha") (:form . "interferon-alpha")\n  (:end . 44) (:start . 28) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 134) (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 176)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cortisol-resistant") (:form . "cortisol-resistant")\n  (:end . 198) (:start . 180) (:id . 71))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 203) (:start . 199)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "attribute") (:form . "attributing") (:end . 216)\n  (:start . 205) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 225) (:start . 221)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 237)\n  (:start . 229) (:id . 78))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 248)\n  (:start . 238) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 251) (:start . 249)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 255) (:start . 252)\n  (:id . 81))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 261)\n  (:start . 256) (:id . 82))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 272)\n  (:start . 262) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x355.3.2) (:span 157 163))\n  ((:id . :x355.3.3) (:span 72 84)))\n (:ncues ((:id . :x355.3.1) (:span 221 225)))\n (:hscopes ((:id . :x355.3.2) (:span 90 203))\n  ((:id . :x355.3.3) (:span 72 272)))\n (:nscopes ((:id . :x355.3.1) (:span 221 248)))\n (:identifiers (:sid . :s355.3) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003256@unknown@formal@none@1@S@Therefore, we examined glucocorticoid receptor characteristics on monocytes by [3H]dexamethasone binding and measured IFN alpha, cortisol, and ACTH in AIDS patients with (AIDS-GR) or without glucocorticoid resistance (AIDS-C) and controls (C).@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 62) (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "3H]dexamethasone") (:form . "3H]dexamethasone")\n  (:end . 96) (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 127)\n  (:start . 122) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ACTH") (:form . "ACTH") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "AIDS-GR") (:form . "AIDS-GR") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 190)\n  (:start . 183) (:id . 72))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 205) (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 216)\n  (:start . 206) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 218) (:start . 217)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "AIDS-C") (:form . "AIDS-C") (:end . 224)\n  (:start . 218) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 225) (:start . 224)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 229) (:start . 226)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 238)\n  (:start . 230) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 240) (:start . 239)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 241) (:start . 240)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 242) (:start . 241)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x355.4.1) (:span 183 190)))\n (:nscopes ((:id . :x355.4.1) (:span 183 242)))\n (:identifiers (:sid . :s355.4) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003257@unknown@formal@none@1@S@Monocytes of AIDS-GR patients had a receptor Kd of 10.5 ± 4.2 nmol/L that was higher than that in the AIDS-C group (2.9 ± 0.8 nmol/L) and normal subjects (2.0 ± 0.8 nmol/L; P < 0.01).@(((:tag . "NNS") (:stem . "monocyte") (:form . "Monocytes") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "AIDS-GR") (:form . "AIDS-GR") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "kd") (:form . "Kd") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "10.5") (:form . "10.5") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4.2") (:form . "4.2") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nmol/l") (:form . "nmol/L") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 84) (:start . 78)\n  (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "AIDS-C") (:form . "AIDS-C") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "CD") (:stem . "2.9") (:form . "2.9") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 121) (:start . 120)\n  (:id . 66))\n ((:tag . "CD") (:stem . "0.8") (:form . "0.8") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "NN") (:stem . "nmol/l") (:form . "nmol/L") (:end . 132)\n  (:start . 126) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 144)\n  (:start . 138) (:id . 71))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 153)\n  (:start . 145) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 73))\n ((:tag . "CD") (:stem . "2.0") (:form . "2.0") (:end . 158) (:start . 155)\n  (:id . 74))\n ((:tag . "SYM") (:stem . "±") (:form . "±") (:end . 160) (:start . 159)\n  (:id . 75))\n ((:tag . "CD") (:stem . "0.8") (:form . "0.8") (:end . 164) (:start . 161)\n  (:id . 76))\n ((:tag . "NN") (:stem . "nmol/l") (:form . "nmol/L") (:end . 171)\n  (:start . 165) (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 172) (:start . 171)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 174) (:start . 173)\n  (:id . 79))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 176) (:start . 175)\n  (:id . 80))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 181) (:start . 177)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s355.5) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003258@unknown@formal@none@1@S@IFN alpha levels were increased in the AIDS-GR group (17 ± 6 vs.@(((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AIDS-GR") (:form . "AIDS-GR") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "±") (:form . "±") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "v") (:form . "vs") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s355.6) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003260@unknown@formal@none@1@S@Correlations were found between plasma IFN alpha and receptor Kd on monocytes of AIDS-GR (r = 0.77) and between IFN alpha and plasma cortisol in the same group (r = 0.74).@(((:tag . "NNS") (:stem . "correlation") (:form . "Correlations") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "kd") (:form . "Kd") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AIDS-GR") (:form . "AIDS-GR") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "r") (:form . "r") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.77") (:form . "0.77") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "SYM") (:stem . "alpha") (:form . "alpha") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 132)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 153) (:start . 149)\n  (:id . 70))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 159)\n  (:start . 154) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "NN") (:stem . "r") (:form . "r") (:end . 162) (:start . 161)\n  (:id . 73))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 164) (:start . 163)\n  (:id . 74))\n ((:tag . "CD") (:stem . "0.74") (:form . "0.74") (:end . 169) (:start . 165)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s355.8) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003261@unknown@formal@none@1@S@The poly(I)-poly(C)-induced IFN alpha production by monocytes was inhibited by glucocorticoids in the C and AIDS-C groups (approximately 80% inhibition in both groups);@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "poly(I)-poly(C)-induced")\n  (:form . "poly(I)-poly(C)-induced") (:end . 27) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 37) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 61)\n  (:start . 52) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 94) (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AIDS-C") (:form . "AIDS-C") (:end . 114)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 151)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 166)\n  (:start . 160) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s355.9) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003262@unknown@formal@none@1@S@the effect was reversed by the receptor antagonist RU-38486.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "RU-38486") (:form . "RU-38486") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s355.10) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003263@unknown@formal@none@1@S@By contrast, glucocorticoids failed to inhibit IFNalpha production from AIDS-GR monocytes (approximately 20% inhibition).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 35) (:start . 29)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "IFNalpha") (:form . "IFNalpha") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AIDS-GR") (:form . "AIDS-GR") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 104) (:start . 91) (:id . 55))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s355.11) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003264@unknown@formal@none@1@S@In conclusion, elevated IFN alpha levels in AIDS-GR may be due to the lack of inhibitory effect of cortisol on IFN alpha production due to cortisol resistance in monocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "AIDS-GR") (:form . "AIDS-GR") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 88)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 131)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 147)\n  (:start . 139) (:id . 68))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 158)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 171)\n  (:start . 162) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x355.12.2) (:span 52 55)))\n (:ncues ((:id . :x355.12.1) (:span 70 74)))\n (:hscopes ((:id . :x355.12.2) (:span 52 171)))\n (:nscopes ((:id . :x355.12.1) (:span 70 131)))\n (:identifiers (:sid . :s355.12) (:did . :|96272884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003265@unknown@formal@none@1@S@Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.@(((:tag . "NNP") (:stem . "Cooperation") (:form . "Cooperation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 82)\n  (:start . 71) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 105) (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-3") (:form . "interleukin-3")\n  (:end . 133) (:start . 120) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s356.1) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003266@unknown@formal@none@1@S@Tissue-specific expression of interleukin-3 (IL-3) is mediated via cis-acting elements located within 315 base pairs of the transcription start.@(((:tag . "JJ") (:stem . "tissue-specific") (:form . "Tissue-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-3") (:form . "interleukin-3")\n  (:end . 43) (:start . 30) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "CD") (:stem . "315") (:form . "315") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s356.2) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003267@unknown@formal@none@1@S@This is achieved in part through the positive activities of the AP-1 and Elf-1 sites in the IL-3 promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s356.3) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003268@unknown@formal@none@1@S@The contribution to T cell-specific expression by other promoter sites was assessed in a transient expression assay with IL-3 promoter constructs linked to a luciferase gene, focusing initially on the core binding factor (CBF) site, which is footprinted in vivo upon T cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . 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5003270@unknown@formal@none@1@S@Together the Act-1 and CBF sites form a functional unit (AC unit) with dual activity.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "act-1") (:form . "Act-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cbf") (:form . "CBF") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AC") (:form . "AC") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s356.6) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003271@unknown@formal@none@1@S@The AC unit is demonstrated to enhance basal activity of promoters both in fibroblasts and T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "AC") (:form . "AC") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 27)\n  (:start . 15) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s356.7) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003272@unknown@formal@none@1@S@This activity is further inducible in activated T cells, but not in fibroblasts.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x356.8.1) (:span 61 64)))\n (:nscopes ((:id . :x356.8.1) (:span 61 79)))\n (:identifiers (:sid . :s356.8) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003273@unknown@formal@none@1@S@In addition to the already identified NIP repressor site, evidence is presented for a second repressor region that restricts promoter activity in fibroblasts.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "NIP") (:form . "NIP") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "restrict") (:form . "restricts") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 157)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s356.9) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003274@unknown@formal@none@1@S@Finally, a novel positive regulatory element has been mapped in the IL-3 promoter between nucleotide -180 and -210 that leads to increased expression in T cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 60) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "CD") (:stem . "-180") (:form . "-180") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "CD") (:stem . "-210") (:form . "-210") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s356.10) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003275@unknown@formal@none@1@S@Together these results demonstrate that T cell expression of IL-3 is not specified by the activity of a single tissue-specific element, but instead involves multiple interacting elements that provide both specific positive regulation in T cells and specific negative regulation in fibroblasts.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "specify") (:form . "specified") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 126) (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 177)\n  (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 199)\n  (:start . 192) (:id . 71))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 204) (:start . 200)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 213)\n  (:start . 205) (:id . 73))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 222)\n  (:start . 214) (:id . 74))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 233)\n  (:start . 223) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 238) (:start . 237)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 244)\n  (:start . 239) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 248) (:start . 245)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 257)\n  (:start . 249) (:id . 80))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 266)\n  (:start . 258) (:id . 81))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 277)\n  (:start . 267) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 280) (:start . 278)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 292)\n  (:start . 281) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x356.11.1) (:span 69 72)))\n (:nscopes ((:id . :x356.11.1) (:span 69 134)))\n (:identifiers (:sid . :s356.11) (:did . :|96278851|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003276@unknown@formal@none@1@S@A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 3) (:start . 2)\n  (:id . 43))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 4) (:start . 3)\n  (:id . 44))\n ((:tag . "SYM") (:stem . ">") (:form . "–>") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 10) (:start . 9)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 11) (:start . 10)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 15) (:start . 12)\n  (:id . 48))\n ((:tag . "NN") (:stem . "helicase") (:form . "helicase") (:end . 24)\n  (:start . 16) (:id . 49))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 31)\n  (:start . 25) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 51))\n ((:tag . "NN") (:stem . "repair/transcription")\n  (:form . "repair/transcription") (:end . 55) (:start . 35) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "tfiih") (:form . "TFIIH") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "xeroderma") (:form . "xeroderma") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "pigmentosum") (:form . "pigmentosum") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 143) (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s357.1) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003277@unknown@formal@none@1@S@XPB is a subunit of the basal transcription factor TFIIH, which is also involved in nucleotide excision repair (NER) and potentially in cell cycle regulation.@(((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "TFIIH") (:form . "TFIIH") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "excision") (:form . "excision") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NER") (:form . "NER") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 132)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 146)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 157)\n  (:start . 147) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s357.2) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003278@unknown@formal@none@1@S@A frameshift mutation in the 3'-end of the XPB gene is responsible for a concurrence of two disorders: xeroderma pigmentosum (XP) and Cockayne 's syndrome (CS).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "frameshift") (:form . "frameshift") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "3'-end") (:form . "3'-end") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "concurrence") (:form . "concurrence") (:end . 84)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "xeroderma") (:form . "xeroderma") (:end . 112)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "pigmentosum") (:form . "pigmentosum") (:end . 124)\n  (:start . 113) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "XP") (:form . "XP") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Cockayne") (:form . "Cockayne") (:end . 142)\n  (:start . 134) (:id . 67))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 145) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 154)\n  (:start . 146) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "CS") (:form . "CS") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s357.3) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003280@unknown@formal@none@1@S@Although identical in composition and stoichiometry to TFIIHwt, TFIIHmut shows a reduced 3' --> 5' XPB helicase activity.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stoichiometry") (:form . "stoichiometry")\n  (:end . 51) (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TFIIHwt") (:form . "TFIIHwt") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TFIIHmut") (:form . "TFIIHmut") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "SYM") (:stem . ">") (:form . "–>") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "helicase") (:form . "helicase") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s357.5) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003281@unknown@formal@none@1@S@A decrease in helicase and DNA-dependent ATPase activities was also observed with the mutated recombinant XPB protein.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "helicase") (:form . "helicase") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dna-dependent") (:form . "DNA-dependent")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "ATPase") (:form . "ATPase") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s357.6) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003282@unknown@formal@none@1@S@The XPB mutation causes a severe NER defect.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "ner") (:form . "NER") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s357.7) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003283@unknown@formal@none@1@S@In addition, we provide evidence for a decrease in basal transcription activity in vitro.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s357.8) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003284@unknown@formal@none@1@S@The latter defect may provide an explanation for many of the XP and CS symptoms that are difficult to rationalize based solely on an NER defect.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "XP") (:form . "XP") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CS") (:form . "CS") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "VB") (:stem . "rationalize") (:form . "rationalize") (:end . 113)\n  (:start . 102) (:id . 61))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "RB") (:stem . "solely") (:form . "solely") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NER") (:form . "NER") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x357.9.1) (:span 18 21)))\n (:hscopes ((:id . :x357.9.1) (:span 18 143)))\n (:identifiers (:sid . :s357.9) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003285@unknown@formal@none@1@S@Thus, this work presents the first detailed analysis of a naturally occurring mutation in a basal transcription factor and supports the concept that the combined XP/CS clinical entity is actually the result of a combined transcription/repair deficiency.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "present") (:form . "presents") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "concept") (:form . "concept") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "xp/cs") (:form . "XP/CS") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "entity") (:form . "entity") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "RB") (:stem . "actually") (:form . "actually") (:end . 195)\n  (:start . 187) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 206)\n  (:start . 200) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 211) (:start . 210)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 220)\n  (:start . 212) (:id . 77))\n ((:tag . "NN") (:stem . "transcription/repair")\n  (:form . "transcription/repair") (:end . 241) (:start . 221) (:id . 78))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 252)\n  (:start . 242) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s357.10) (:did . :|96279126|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003286@unknown@formal@none@1@S@Signals leading to the activation of NF-kappa B transcription factor are stronger in neonatal than adult T lymphocytes.@(((:tag . "NNS") (:stem . "signal") (:form . "Signals") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 15) (:start . 8)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s358.1) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003287@unknown@formal@none@1@S@The molecular background of the defects in the immune reactivity of human neonates has not been fully elucidated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "neonate") (:form . "neonates") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x358.2.1) (:span 87 90)))\n (:nscopes ((:id . :x358.2.1) (:span 0 112)))\n (:identifiers (:sid . :s358.2) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003288@unknown@formal@none@1@S@As the NF-kappa B transcription factor has a central role in the control of transcription of several genes involved in immune and inflammatory responses, the authors have analysed the activation of NF-kappa B in human umbilical cord T lymphocytes.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 142)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 206)\n  (:start . 198) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 208) (:start . 207)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 217)\n  (:start . 212) (:id . 77))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 227)\n  (:start . 218) (:id . 78))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 234) (:start . 233)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 246)\n  (:start . 235) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s358.3) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003290@unknown@formal@none@1@S@The data obtained demonstrate that phorbol dibutyrate/calcium ionophore A23187 (PDBu/iono) combination induced a clearly higher nuclear translocation of NF-kappa B in neonatal than adult T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "dibutyrate/calcium") (:form . "dibutyrate/calcium")\n  (:end . 61) (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 71)\n  (:start . 62) (:id . 49))\n ((:tag . "NNP") (:stem . "A23187") (:form . "A23187") (:end . 78)\n  (:start . 72) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PDBu/iono") (:form . "PDBu/iono") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 102)\n  (:start . 91) (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 149) (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 161)\n  (:start . 153) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 163) (:start . 162)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 175)\n  (:start . 167) (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 180) (:start . 176)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 186)\n  (:start . 181) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 188) (:start . 187)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s358.5) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003291@unknown@formal@none@1@S@This higher NF-kappa B activity was restricted to the CD4+ T-cell subset.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s358.6) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003292@unknown@formal@none@1@S@Analysis of the nuclear extracts with antibodies directed against the major components of NF-kappa B the p50 and RelA (p65) proteins , indicated that the composition of NF-kappa B was similar in neonatal and adult cells.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 144)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 165)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 191)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 203)\n  (:start . 195) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 213)\n  (:start . 208) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 219)\n  (:start . 214) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s358.7) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003293@unknown@formal@none@1@S@These results suggest that neonatal T cells are exposed to oxidative stress-inducing signals during delivery and/or are inherently more sensitive to NF-kappa B activating signals than adult T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "stress-inducing") (:form . "stress-inducing")\n  (:end . 84) (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "inherently") (:form . "inherently") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 145)\n  (:start . 136) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 178)\n  (:start . 171) (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 183) (:start . 179)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 189)\n  (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 191) (:start . 190)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x358.8.1) (:span 109 115))\n  ((:id . :x358.8.2) (:span 14 21)))\n (:hscopes ((:id . :x358.8.1) (:span 44 197))\n  ((:id . :x358.8.2) (:span 14 197)))\n (:identifiers (:sid . :s358.8) (:did . :|96285641|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003294@unknown@formal@none@1@S@Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "grb2-binding") (:form . "Grb2-binding") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RIIA") (:form . "RIIA") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 101) (:start . 88) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s359.1) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003295@unknown@formal@none@1@S@Glutathione-S-transferase ( GST ) -Grb2 fusion proteins have been used to identify the potential role of Grb2-binding proteins in platelet activation by the platelet low-affinity IgG receptor, Fc gamma RIIA.@(((:tag . "NNP") (:stem . "Glutathione-S-transferase")\n  (:form . "Glutathione-S-transferase") (:end . 25) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GST") (:form . "GST") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "-grb2") (:form . "-Grb2") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "grb2-binding") (:form . "Grb2-binding") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 126)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "low-affinity") (:form . "low-affinity") (:end . 178)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "igg") (:form . "IgG") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 191)\n  (:start . 183) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 201)\n  (:start . 196) (:id . 71))\n ((:tag . "NNP") (:stem . "RIIA") (:form . "RIIA") (:end . 206) (:start . 202)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s359.2) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003296@unknown@formal@none@1@S@Two tyrosine phosphoproteins of 38 and 63 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of platelets.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "phosphoprotein") (:form . "phosphoproteins")\n  (:end . 28) (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "CD") (:stem . "63") (:form . "63") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RIIA") (:form . "RIIA") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 111)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 124)\n  (:start . 115) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s359.3) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003297@unknown@formal@none@1@S@Both are located in the particulate fraction following platelet activation and are also able to bind to a GST-construct containing the SH2 and SH3 domains of phospholipase C gamma 1.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "particulate") (:form . "particulate") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gst-construct") (:form . "GST-construct")\n  (:end . 119) (:start . 106) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sh3") (:form . "SH3") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 171) (:start . 158) (:id . 68))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 181) (:start . 180)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s359.4) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003298@unknown@formal@none@1@S@p38 also forms a complex with the tyrosine kinase csk in stimulated cells and is a substrate for the kinase.@(((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "csk") (:form . "csk") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s359.5) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003300@unknown@formal@none@1@S@The 75-kD protein is recognized by antibodies to SLP-76, which has recently been isolated from T cells and sequenced.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "75-kd") (:form . "75-kD") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s359.7) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003301@unknown@formal@none@1@S@Tyrosine phosphorylation of p38 and p63 is also observed in platelets stimulated by the tyrosine kinase-linked receptor agonist collagen and by the G protein-coupled receptor agonist thrombin, although phosphorylation of SLP-76 is only observed in collagen-stimulated platelets.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p63") (:form . "p63") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "JJ") (:stem . "kinase-linked") (:form . "kinase-linked")\n  (:end . 110) (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "collagen") (:form . "collagen") (:end . 136)\n  (:start . 128) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "protein-coupled") (:form . "protein-coupled")\n  (:end . 165) (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 182)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 191)\n  (:start . 183) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 69))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 201)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 217) (:start . 202) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 227)\n  (:start . 221) (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 230) (:start . 228)\n  (:id . 74))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 235) (:start . 231)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 244)\n  (:start . 236) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "collagen-stimulated")\n  (:form . "collagen-stimulated") (:end . 267) (:start . 248) (:id . 78))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 277)\n  (:start . 268) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s359.8) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003302@unknown@formal@none@1@S@p38 and p63 may provide a docking site for Grb2, thereby linking Grb2 SH3-binding proteins SOS1, SLP-76, and p120 to downstream signalling events.@(((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p63") (:form . "p63") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 56)\n  (:start . 49) (:id . 53))\n ((:tag . "VBG") (:stem . "link") (:form . "linking") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "sh3-binding") (:form . "SH3-binding") (:end . 81)\n  (:start . 70) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "NNP") (:stem . "SOS1") (:form . "SOS1") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p120") (:form . "p120") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 127)\n  (:start . 117) (:id . 65))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 138)\n  (:start . 128) (:id . 66))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 145)\n  (:start . 139) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x359.9.1) (:span 12 15)))\n (:hscopes ((:id . :x359.9.1) (:span 12 145)))\n (:identifiers (:sid . :s359.9) (:did . :|96289501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003303@unknown@formal@none@1@S@Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 54)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s360.1) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003304@unknown@formal@none@1@S@All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL).@(((:tag . "JJ") (:stem . "all-trans-retinoic") (:form . "All-trans-retinoic")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 23) (:start . 19)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "choice") (:form . "choice") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 92) (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s360.2) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003305@unknown@formal@none@1@S@ATRA induces both in vitro and in vivo differentiation of APL cells into mature granulocytes.@(((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 54) (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s360.3) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003306@unknown@formal@none@1@S@However, the molecular mechanisms involved in ATRA-dependent growth inhibition and cellular differentiation are not presently understood.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "atra-dependent") (:form . "ATRA-dependent")\n  (:end . 60) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 107) (:start . 92) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "RB") (:stem . "presently") (:form . "presently") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 136)\n  (:start . 126) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x360.4.1) (:span 112 115)))\n (:nscopes ((:id . :x360.4.1) (:span 9 136)))\n (:identifiers (:sid . :s360.4) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003307@unknown@formal@none@1@S@The NB4 cell line, which is derived from the bone marrow of a patient with APL during relapse, can be used as a model system to study the growth and differentiation of APL cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 35)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 56)\n  (:start . 50) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 69)\n  (:start . 62) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 85)\n  (:start . 79) (:id . 59))\n ((:tag . "NN") (:stem . "relapse") (:form . "relapse") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 98) (:start . 95)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 106) (:start . 102)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 109) (:start . 107)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 66))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 117)\n  (:start . 112) (:id . 67))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 124)\n  (:start . 118) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 69))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 133)\n  (:start . 128) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 71))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 144)\n  (:start . 138) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 73))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 164) (:start . 149) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 171) (:start . 168)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s360.5) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003308@unknown@formal@none@1@S@Because interferon (IFN) regulatory factors (IRF-1 and IRF-2) and other IFN-inducible gene products regulate cell growth, we analyzed the effects of ATRA on the expression of these genes.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "irf-2") (:form . "IRF-2") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ifn-inducible") (:form . "IFN-inducible")\n  (:end . 85) (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 180)\n  (:start . 175) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 186)\n  (:start . 181) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s360.6) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003310@unknown@formal@none@1@S@In addition to NB4 cells, ATRA also activated IRF-1 gene expression in HL-60, U937, and THP-1 cells, which all respond to ATRA by growth inhibition.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 93) (:start . 88)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 63))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 118)\n  (:start . 111) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 126) (:start . 122)\n  (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 68))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 136)\n  (:start . 130) (:id . 69))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 147)\n  (:start . 137) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s360.8) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003311@unknown@formal@none@1@S@A more than additive increase in IRF-1 gene expression was seen with ATRA and IFN-gamma in NB4 cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "additive") (:form . "additive") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s360.9) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003312@unknown@formal@none@1@S@ATRA did not activate nuclear factor kappa B or signal transducer and activator of transcription (STAT) activation pathways, suggesting that an alternate mechanism is involved in IRF-1 gene activation.@(((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "alternate") (:form . "alternate") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 184)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 200)\n  (:start . 190) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x360.10.1) (:span 125 135)))\n (:ncues ((:id . :x360.10.2) (:span 9 12)))\n (:hscopes ((:id . :x360.10.1) (:span 125 200)))\n (:nscopes ((:id . :x360.10.2) (:span 9 123)))\n (:identifiers (:sid . :s360.10) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003313@unknown@formal@none@1@S@The ATRA-induced expression of IRF-1, an activator of transcription and repressor of transformation, may be one of the molecular mechanisms of ATRA-induced growth inhibition, and the basis for the synergistic actions of ATRA and IFNs in myeloid leukemia cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "atra-induced") (:form . "ATRA-induced") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 99) (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "atra-induced") (:form . "ATRA-induced") (:end . 155)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 173)\n  (:start . 163) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 188)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 208)\n  (:start . 197) (:id . 74))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 224) (:start . 220)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 233) (:start . 229)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 244)\n  (:start . 237) (:id . 81))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 253)\n  (:start . 245) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 259)\n  (:start . 254) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x360.11.1) (:span 101 104)))\n (:hscopes ((:id . :x360.11.1) (:span 101 259)))\n (:identifiers (:sid . :s360.11) (:did . :|96290415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003314@unknown@formal@none@1@S@The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "delta-domain") (:form . "delta-domain") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "neuroendocrine") (:form . "neuroendocrine")\n  (:end . 46) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence-") (:form . "sequence-") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "pituitary-specific") (:form . "pituitary-specific")\n  (:end . 106) (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 113)\n  (:start . 107) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s361.1) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003315@unknown@formal@none@1@S@The transcription and transformation activity of c-Jun is governed by a 27-amino acid regulatory motif, labeled the delta-domain, which is deleted in v-Jun.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 36) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "govern") (:form . "governed") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "27-amino") (:form . "27-amino") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "label") (:form . "labeled") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "delta-domain") (:form . "delta-domain") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "v-jun") (:form . "v-Jun") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s361.2) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003316@unknown@formal@none@1@S@We have previously shown that c-Jun is a potent inhibitor of the rat prolactin (rPRL) promoter activity induced by either oncogenic Ras or phorbol esters.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "prolactin") (:form . "prolactin") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rprl") (:form . "rPRL") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 121)\n  (:start . 115) (:id . 63))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 131)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "ras") (:form . "Ras") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s361.3) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003317@unknown@formal@none@1@S@Here, we have characterized the structural and cell-specific requirements for this c-Jun inhibitory response, and we show that this c-Jun inhibitory response mapped to the rPRL footprint II repressor site, was pituitary-specific and required the c-Jun delta-domain.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 27) (:start . 14) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "rprl") (:form . "rPRL") (:end . 176) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 186)\n  (:start . 177) (:id . 70))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 199)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 204) (:start . 200)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 209) (:start . 206)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "pituitary-specific") (:form . "pituitary-specific")\n  (:end . 228) (:start . 210) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 232) (:start . 229)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 241)\n  (:start . 233) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 79))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 251)\n  (:start . 246) (:id . 80))\n ((:tag . "NN") (:stem . "delta-domain") (:form . "delta-domain") (:end . 264)\n  (:start . 252) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s361.4) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003318@unknown@formal@none@1@S@Moreover, alteration of any one of these features (e.g., cis-element, trans-factor, or cell-specific background) switched c-Jun to a transcriptional activator of the rPRL promoter.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cis-element") (:form . "cis-element") (:end . 68)\n  (:start . 57) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "trans-factor") (:form . "trans-factor") (:end . 82)\n  (:start . 70) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 100) (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "switch") (:form . "switched") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 148) (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "rprl") (:form . "rPRL") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s361.5) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003320@unknown@formal@none@1@S@Finally, recombinant GHF-1 interacted directly with c-Jun but not c-Fos proteins.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "ghf-1") (:form . "GHF-1") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x361.7.1) (:span 62 65)))\n (:nscopes ((:id . :x361.7.1) (:span 62 80)))\n (:identifiers (:sid . :s361.7) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003321@unknown@formal@none@1@S@These data provide important fundamental insights into the molecular mechanisms by which the c-Jun delta-domain functions as a modulatory switch and further imply that the functional role of c-Jun is dictated by cell-specific influences and the delta-domain motif.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "fundamental") (:form . "fundamental") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "delta-domain") (:form . "delta-domain") (:end . 111)\n  (:start . 99) (:id . 56))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "modulatory") (:form . "modulatory") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 144)\n  (:start . 138) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 156)\n  (:start . 149) (:id . 63))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 162)\n  (:start . 157) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 182)\n  (:start . 172) (:id . 67))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 187) (:start . 183)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "dictate") (:form . "dictated") (:end . 208)\n  (:start . 200) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 211) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 225) (:start . 212) (:id . 74))\n ((:tag . "NNS") (:stem . "influence") (:form . "influences") (:end . 236)\n  (:start . 226) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "delta-domain") (:form . "delta-domain") (:end . 257)\n  (:start . 245) (:id . 78))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 263)\n  (:start . 258) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x361.8.1) (:span 157 162)))\n (:hscopes ((:id . :x361.8.1) (:span 157 263)))\n (:identifiers (:sid . :s361.8) (:did . :|96291858|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003322@unknown@formal@none@1@S@BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.@(((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "POZ/zinc-finger") (:form . "POZ/zinc-finger")\n  (:end . 24) (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 56) (:start . 39) (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s362.1) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003323@unknown@formal@none@1@S@Approximately 40% of diffuse large cell lymphoma are associated with chromosomal translocations that deregulate the expression of the BCL6 gene by juxtaposing heterologous promoters to the BCL-6 coding domain.@(((:tag . "RB") (:stem . "approximately") (:form . "Approximately")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "diffuse") (:form . "diffuse") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 95) (:start . 81) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "deregulate") (:form . "deregulate") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "juxtapose") (:form . "juxtaposing") (:end . 158)\n  (:start . 147) (:id . 64))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 171)\n  (:start . 159) (:id . 65))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 181)\n  (:start . 172) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 194)\n  (:start . 189) (:id . 69))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 201)\n  (:start . 195) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 208)\n  (:start . 202) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s362.2) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003324@unknown@formal@none@1@S@The BCL6 gene encodes a 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain, suggesting that it may function as a transcription factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "95-kda") (:form . "95-kDa") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NNP") (:stem . "POZ") (:form . "POZ") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 164) (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 171)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x362.3.1) (:span 133 136))\n  ((:id . :x362.3.2) (:span 114 124)))\n (:hscopes ((:id . :x362.3.1) (:span 133 171))\n  ((:id . :x362.3.2) (:span 114 171)))\n (:identifiers (:sid . :s362.3) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003325@unknown@formal@none@1@S@By using a DNA sequence selected for its ability to bind recombinant BCL-6 in vitro, we show here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 108)\n  (:start . 103) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 119)\n  (:start . 112) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 134)\n  (:start . 123) (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 144)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 169) (:start . 165)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 177)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 190)\n  (:start . 185) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s362.4) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003326@unknown@formal@none@1@S@In transient transfectin experiments, BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "transfectin") (:form . "transfectin") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 90) (:start . 84)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 174)\n  (:start . 163) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 204)\n  (:start . 198) (:id . 72))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 215)\n  (:start . 205) (:id . 73))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 220) (:start . 216)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 235)\n  (:start . 228) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s362.5) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003327@unknown@formal@none@1@S@We demonstrate that this part of the BCL6 molecule contains an autonomous transrepressor domain and that two noncontiguous regions, including the POZ motif, mediate maximum transrepressive activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "transrepressor") (:form . "transrepressor")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "noncontiguous") (:form . "noncontiguous")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 141)\n  (:start . 132) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "POZ") (:form . "POZ") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "JJ") (:stem . "transrepressive") (:form . "transrepressive")\n  (:end . 188) (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 197)\n  (:start . 189) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s362.6) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003328@unknown@formal@none@1@S@These results indicate that the BCL-6 protein can function as a sequence-specific transcriptional repressor and have implications for the role of BCL6 in normal lymphoid development and lymphomagenesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 81) (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 97) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 129)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bcl6") (:form . "BCL6") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 169)\n  (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 181)\n  (:start . 170) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lymphomagenesis") (:form . "lymphomagenesis")\n  (:end . 201) (:start . 186) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x362.7.1) (:span 46 49)) ((:id . :x362.7.2) (:span 14 27)))\n (:hscopes ((:id . :x362.7.1) (:span 46 107))\n  ((:id . :x362.7.2) (:span 14 107)))\n (:identifiers (:sid . :s362.7) (:did . :|96293454|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003330@unknown@formal@none@1@S@Constitutive expression of IFN-alpha5 and IFN-beta was detected in different lymphoid cells including peripheral blood mononuclear cells from normal individuals following amplification of IFN mRNA by reverse transcriptase-polymerase chain reaction and direct sequencing of the amplified product.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IFN-alpha5") (:form . "IFN-alpha5") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 130)\n  (:start . 119) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 148)\n  (:start . 142) (:id . 60))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 160)\n  (:start . 149) (:id . 61))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 170)\n  (:start . 161) (:id . 62))\n ((:tag . "NN") (:stem . "amplification") (:form . "amplification")\n  (:end . 184) (:start . 171) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 191) (:start . 188)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 196) (:start . 192)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 199) (:start . 197)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 207)\n  (:start . 200) (:id . 68))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 232) (:start . 208) (:id . 69))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 238)\n  (:start . 233) (:id . 70))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 247)\n  (:start . 239) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 251) (:start . 248)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 258)\n  (:start . 252) (:id . 73))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 269)\n  (:start . 259) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 272) (:start . 270)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 276) (:start . 273)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 286)\n  (:start . 277) (:id . 77))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 294)\n  (:start . 287) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s363.2) (:did . :|96295969|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003331@unknown@formal@none@1@S@The activated form of the interferon-induced transcription factor complex ISGF3 was also detected in nuclear extracts from uninduced cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "activated") (:form . "activated") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "interferon-induced") (:form . "interferon-induced")\n  (:end . 44) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "isgf3") (:form . "ISGF3") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s363.3) (:did . :|96295969|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003332@unknown@formal@none@1@S@Culture supernatants from uninduced U937 cells were also found to activate an ISRE cloned upstream of the luciferase reporter gene, indicating the presence of endogenous IFN activity equivalent to approximately 0.3 to 0.5 IU/mL.@(((:tag . "NNP") (:stem . "Culture") (:form . "Culture") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "isre") (:form . "ISRE") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 169)\n  (:start . 159) (:id . 67))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 182)\n  (:start . 174) (:id . 69))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 210) (:start . 197) (:id . 72))\n ((:tag . "CD") (:stem . "0.3") (:form . "0.3") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 221) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "iu/ml") (:form . "IU/mL") (:end . 227)\n  (:start . 222) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x363.4.1) (:span 132 142)))\n (:hscopes ((:id . :x363.4.1) (:span 132 227)))\n (:identifiers (:sid . :s363.4) (:did . :|96295969|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003333@unknown@formal@none@1@S@This endogenous IFN was also shown to play a role in maintaining the basal level of expression of the major histocompatibility class I genes in lymphoid cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 64)\n  (:start . 53) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 126) (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s363.5) (:did . :|96295969|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003334@unknown@formal@none@1@S@These results suggest that IFN-alpha5 and IFN-beta are produced at low levels in normal tissues and play an important role in the regulation of cell function and in the maintenance of homeostasis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-alpha5") (:form . "IFN-alpha5") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 140)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 180)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 195)\n  (:start . 184) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x363.6.1) (:span 14 21)))\n (:hscopes ((:id . :x363.6.1) (:span 14 195)))\n (:identifiers (:sid . :s363.6) (:did . :|96295969|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003335@unknown@formal@none@1@S@Mechanisms of transactivation by nuclear factor of activated T cells-1.@(((:tag . "NNPS") (:stem . "Mechanism") (:form . "Mechanisms") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cells-1") (:form . "cells-1") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s364.1) (:did . :|96305196|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003336@unknown@formal@none@1@S@Nuclear factor of activated T cells-family proteins (NFAT1/NFATp, NFATc, NFAT3, and NFAT4/NFATx/NFATc3) play a key role in the transcription of cytokine genes and other genes during the immune response.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cells-family") (:form . "cells-family") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT1/NFATp") (:form . "NFAT1/NFATp") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT3") (:form . "NFAT3") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NFAT4/NFATx/NFATc3") (:form . "NFAT4/NFATx/NFATc3")\n  (:end . 102) (:start . 84) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 181)\n  (:start . 175) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 192)\n  (:start . 186) (:id . 74))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 201)\n  (:start . 193) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s364.2) (:did . :|96305196|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003337@unknown@formal@none@1@S@We have defined the mechanisms of transactivation by NFAT1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 49) (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT1") (:form . "NFAT1") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s364.3) (:did . :|96305196|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003338@unknown@formal@none@1@S@NFAT1 possesses two transactivation domains whose sequences are not conserved in the other NFAT-family proteins, and a conserved DNA-binding domain that mediates the recruitment of cooperating nuclear transcription factors even when it is expressed in the absence of other regions of the protein.@(((:tag . "NNP") (:stem . "NFAT1") (:form . "NFAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "possess") (:form . "possesses") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 35) (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . 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5003340@unknown@formal@none@1@S@Our results emphasize the multiple levels at which NFAT-dependent transactivation is regulated, and predict significant differences in the architecture of cooperative transcription complexes containing different NFAT-family proteins.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "emphasize") (:form . "emphasize") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nfat-dependent") (:form . "NFAT-dependent")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 81) (:start . 66) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 119)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 131)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "architecture") (:form . "architecture") (:end . 151)\n  (:start . 139) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 166)\n  (:start . 155) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 180) (:start . 167) (:id . 64))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 190)\n  (:start . 181) (:id . 65))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 201)\n  (:start . 191) (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 211)\n  (:start . 202) (:id . 67))\n ((:tag . "NNP") (:stem . "NFAT-family") (:form . "NFAT-family") (:end . 223)\n  (:start . 212) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 232)\n  (:start . 224) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s364.6) (:did . :|96305196|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003341@unknown@formal@none@1@S@The Ets protein Spi-B is expressed exclusively in B cells and T cells during development.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s365.1) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003342@unknown@formal@none@1@S@Spi-B and PU.1 are hematopoietic-specific transcription factors that constitute a subfamily of the Ets family of DNA-binding proteins.@(((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 41) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 79)\n  (:start . 69) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s365.2) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003343@unknown@formal@none@1@S@Here we show that contrary to previous reports, PU.1 and Spi-B have very different expression patterns.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "contrary") (:form . "contrary") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s365.3) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003344@unknown@formal@none@1@S@PU.1 is expressed at high levels in B cells, mast cells, megakaryocytes, macrophages, neutrophils, and immature erythroid cells and at lower levels in mature erythrocytes.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 71) (:start . 57) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 84)\n  (:start . 73) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 97)\n  (:start . 86) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 111)\n  (:start . 103) (:id . 62))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 121)\n  (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 140) (:start . 135)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 147)\n  (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 157)\n  (:start . 151) (:id . 70))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 170)\n  (:start . 158) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s365.4) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003345@unknown@formal@none@1@S@PU.1 is completely absent from peripheral T cells and most T cell lines based on sensitive RT-PCR assays.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s365.5) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003346@unknown@formal@none@1@S@In contrast, Spi-B is expressed exclusively in lymphoid cells and can be detected in early fetal thymus and spleen.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s365.6) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003347@unknown@formal@none@1@S@In situ hybridizations of adult murine tissues demonstrate Spi-B mRNA in the medulla of the thymus, the white pulp of the spleen, and the germinal centers of lymph nodes.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "hybridization") (:form . "hybridizations")\n  (:end . 22) (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "medulla") (:form . "medulla") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "pulp") (:form . "pulp") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . "NNS") (:stem . "center") (:form . "centers") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 163)\n  (:start . 158) (:id . 71))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 169)\n  (:start . 164) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s365.7) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003348@unknown@formal@none@1@S@Spi-B expression is very abundant in B cells and both Spi-B mRNA and protein are detected in some T cells.@(((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s365.8) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003350@unknown@formal@none@1@S@Gel-retardation experiments show that Spi-B can bind to all putative PU.1 binding sites, but do not reveal any preferred Spi-B binding site.@(((:tag . "NNP") (:stem . "Gel-retardation") (:form . "Gel-retardation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 32) (:start . 28)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "reveal") (:form . "reveal") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "preferred") (:form . "preferred") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x365.10.2) (:span 60 68)))\n (:ncues ((:id . :x365.10.1) (:span 96 99)))\n (:hscopes ((:id . :x365.10.2) (:span 60 87)))\n (:nscopes ((:id . :x365.10.1) (:span 96 139)))\n (:identifiers (:sid . :s365.10) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003351@unknown@formal@none@1@S@Finally, both PU.1 and Spi-B function as transcriptional activators of the immunoglobulin light-chain enhancer E lambda 2.4 when coexpressed with Pip (PU.1-interaction partner) in NIH-3T3 cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 56) (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "light-chain") (:form . "light-chain") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lambda") (:form . "lambda") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "CD") (:stem . "2.4") (:form . "2.4") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Pip") (:form . "Pip") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PU.1-interaction") (:form . "PU.1-interaction")\n  (:end . 167) (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 175)\n  (:start . 168) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "nih-3t3") (:form . "NIH-3T3") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 193)\n  (:start . 188) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s365.11) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003352@unknown@formal@none@1@S@Taken together, these data suggest that differences in patterns of expression between Spi-B and PU.1 distinguish the function of each protein during development of the immune system.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "distinguish") (:form . "distinguish") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 160)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 174)\n  (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 181)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x365.12.1) (:span 27 34)))\n (:hscopes ((:id . :x365.12.1) (:span 27 181)))\n (:identifiers (:sid . :s365.12) (:did . :|96305203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003353@unknown@formal@none@1@S@Precise alignment of sites required for mu enhancer activation in B cells.@(((:tag . "JJ") (:stem . "precise") (:form . "Precise") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s366.1) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003354@unknown@formal@none@1@S@The lymphocyte-specific immunoglobulin mu heavy-chain gene intronic enhancer is regulated by multiple nuclear factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 23) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 38) (:start . 24) (:id . 44))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 41) (:start . 39)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 53)\n  (:start . 42) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intronic") (:form . "intronic") (:end . 67)\n  (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 76)\n  (:start . 68) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 89)\n  (:start . 80) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 101)\n  (:start . 93) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 117)\n  (:start . 110) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s366.2) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003355@unknown@formal@none@1@S@The previously defined minimal enhancer containing the muA, muE3, and muB sites is transactivated by a combination of the ETS-domain proteins PU.1 and Ets-1 in nonlymphoid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mua") (:form . "muA") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mue3") (:form . "muE3") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mub") (:form . "muB") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 97) (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ETS-domain") (:form . "ETS-domain") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 171)\n  (:start . 160) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s366.3) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003356@unknown@formal@none@1@S@The core GGAAs of the muA and muB sites are separated by 30 nucleotides, suggesting that ETS proteins bind to these sites from these same side of the DNA helix.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "ggaa") (:form . "GGAAs") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mua") (:form . "muA") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mub") (:form . "muB") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 71)\n  (:start . 60) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 83)\n  (:start . 73) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ets") (:form . "ETS") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 132)\n  (:start . 127) (:id . 66))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 153) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "helix") (:form . "helix") (:end . 159)\n  (:start . 154) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x366.4.1) (:span 73 83)))\n (:hscopes ((:id . :x366.4.1) (:span 73 159)))\n (:identifiers (:sid . :s366.4) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003357@unknown@formal@none@1@S@We tested the necessity for appropriate spatial alignment of these elements by using mutated enhancers with altered spacings.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necessity") (:form . "necessity") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "spatial") (:form . "spatial") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "spacing") (:form . "spacings") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s366.5) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003358@unknown@formal@none@1@S@A 4- or 10-bp insertion between muE3 and muB inactivated the mu enhancer in S194 plasma cells but did not affect in vitro binding of Ets-1, PU.1, or the muE3-binding protein TFE3, alone or in pairwise combinations.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4-") (:form . "4-") (:end . 4) (:start . 2)\n  (:id . 43))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 7) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "10-bp") (:form . "10-bp") (:end . 13) (:start . 8)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 23)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "mue3") (:form . "muE3") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "muB") (:form . "muB") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "inactivate") (:form . "inactivated") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "s194") (:form . "S194") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ets-1") (:form . "Ets-1") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 144) (:start . 140)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "mue3-binding") (:form . "muE3-binding") (:end . 165)\n  (:start . 153) (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 173)\n  (:start . 166) (:id . 74))\n ((:tag . "NN") (:stem . "tfe3") (:form . "TFE3") (:end . 178) (:start . 174)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 76))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 185)\n  (:start . 180) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 188) (:start . 186)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "pairwise") (:form . "pairwise") (:end . 200)\n  (:start . 192) (:id . 80))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 213)\n  (:start . 201) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x366.6.1) (:span 102 105)))\n (:nscopes ((:id . :x366.6.1) (:span 102 213)))\n (:identifiers (:sid . :s366.6) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003360@unknown@formal@none@1@S@We propose that the requirement for precise spacing of the muA and muB elements is due in part to a directed DNA bend induced by PU.1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "spacing") (:form . "spacing") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mua") (:form . "muA") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mub") (:form . "muB") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 108)\n  (:start . 100) (:id . 62))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bend") (:form . "bend") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 125)\n  (:start . 118) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x366.8.1) (:span 3 10)))\n (:hscopes ((:id . :x366.8.1) (:span 3 133)))\n (:identifiers (:sid . :s366.8) (:did . :|96315681|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003361@unknown@formal@none@1@S@C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines.@(((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s367.1) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003362@unknown@formal@none@1@S@Previous work has shown that C/EBP sites and C/EBP transcriptional activators are necessary for HIV-1 LTR activity in monocytes/macrophages.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 66) (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 101)\n  (:start . 96) (:id . 56))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 139) (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s367.2) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003363@unknown@formal@none@1@S@We have investigated the role that C/EBP proteins play in induction and replication of HIV-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s367.3) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003364@unknown@formal@none@1@S@Ectopic expression of the dominant negative C/EBP protein LIP inhibited HIV-1 mRNA and virus production in activated U1 cells, demonstrating that C/EBP proteins are required for provirus induction.@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "LIP") (:form . "LIP") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 196)\n  (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s367.4) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003365@unknown@formal@none@1@S@U1 lines overexpressing C/EBP activator NF-IL-6 produced more viral mRNA and virus particles following cellular activation than control lines, demonstrating that C/EBP proteins are limiting for virus transcription.@(((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "nf-il-6") (:form . "NF-IL-6") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "particle") (:form . "particles") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 156) (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 167)\n  (:start . 162) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 176)\n  (:start . 168) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 180) (:start . 177)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 189)\n  (:start . 181) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 193) (:start . 190)\n  (:id . 68))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 199)\n  (:start . 194) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 213) (:start . 200) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s367.5) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003366@unknown@formal@none@1@S@HIV-1 harboring mutations within two C/EBP sites were crippled in their ability to replicate in U937 promonocytic cells, indicating that these sites are required for replication.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "harbor") (:form . "harboring") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "cripple") (:form . "crippled") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 71)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 161)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 177)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x367.6.1) (:span 121 136)))\n (:hscopes ((:id . :x367.6.1) (:span 121 177)))\n (:identifiers (:sid . :s367.6) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003367@unknown@formal@none@1@S@These data identify C/EBP proteins as regulators of HIV-1 expression in monocytes/macrophages.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 93) (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s367.7) (:did . :|96320521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003368@unknown@formal@none@1@S@Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.@(((:tag . "NN") (:stem . "reversal") (:form . "Reversal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "leukaemia-associated")\n  (:form . "leukaemia-associated") (:end . 49) (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "JJ") (:stem . "chimaeric") (:form . "chimaeric") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s368.1) (:did . :|96320558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003370@unknown@formal@none@1@S@Here we report that human leukaemia cells carrying the translocation t(17;19) rapidly died by apoptosis when programmed to express a dominant-negative suppressor of the fusion protein E2A-HLF, indicating that the chimaeric oncoprotein probably affects cell survival rather than cell growth.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "VBZ") (:stem . "t(17;19)") (:form . "t(17;19)") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "VBD") (:stem . "die") (:form . "died") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 150) (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 175)\n  (:start . 169) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 183)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 191)\n  (:start . 184) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 203)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 208) (:start . 204)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "chimaeric") (:form . "chimaeric") (:end . 222)\n  (:start . 213) (:id . 73))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 234)\n  (:start . 223) (:id . 74))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 243)\n  (:start . 235) (:id . 75))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 251)\n  (:start . 244) (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 256) (:start . 252)\n  (:id . 77))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 265)\n  (:start . 257) (:id . 78))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 272)\n  (:start . 266) (:id . 79))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 277) (:start . 273)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 282) (:start . 278)\n  (:id . 81))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 289)\n  (:start . 283) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x368.3.2) (:span 235 243))\n  ((:id . :x368.3.3) (:span 193 208)))\n (:ncues ((:id . :x368.3.1) (:span 266 277)))\n (:hscopes ((:id . :x368.3.2) (:span 235 289))\n  ((:id . :x368.3.3) (:span 193 289)))\n (:nscopes ((:id . :x368.3.1) (:span 266 289)))\n (:identifiers (:sid . :s368.3) (:did . :|96320558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003371@unknown@formal@none@1@S@Moreover, when introduced into murine pro-B lymphocytes, the oncogenic E2A-HLF fusion protein reversed both interleukin-3-dependent and p53-mediated apoptosis.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "pro-b") (:form . "pro-B") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "VBD") (:stem . "reverse") (:form . "reversed") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "interleukin-3-dependent")\n  (:form . "interleukin-3-dependent") (:end . 131) (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "p53-mediated") (:form . "p53-mediated") (:end . 148)\n  (:start . 136) (:id . 60))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 158)\n  (:start . 149) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s368.4) (:did . :|96320558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003372@unknown@formal@none@1@S@The close homology of the basic region/leucine zipper (bZIP) DNA-binding and dimerization domain of HLF to that of the CES-2 cell-death specification protein of Caenorhabditis elegans suggests a model of leukaemogenesis in which E2A-HLF blocks an early step within an evolutionarily conserved cell-death pathway.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region/leucine") (:form . 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"HLF") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ces-2") (:form . "CES-2") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "cell-death") (:form . "cell-death") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 149) (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Caenorhabditis") (:form . "Caenorhabditis")\n  (:end . 175) (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "elegan") (:form . "elegans") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 192)\n  (:start . 184) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 200)\n  (:start . 195) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "leukaemogenesis") (:form . "leukaemogenesis")\n  (:end . 219) (:start . 204) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 228)\n  (:start . 223) (:id . 76))\n ((:tag . "NNP") (:stem . "E2A-HLF") (:form . "E2A-HLF") (:end . 236)\n  (:start . 229) (:id . 77))\n ((:tag . "VBZ") (:stem . "block") (:form . 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(:end . 312) (:start . 311)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x368.5.1) (:span 184 192)))\n (:hscopes ((:id . :x368.5.1) (:span 184 311)))\n (:identifiers (:sid . :s368.5) (:did . :|96320558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003373@unknown@formal@none@1@S@Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 130)\n  (:start . 120) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s369.1) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003374@unknown@formal@none@1@S@Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocytes.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 52))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s369.2) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003375@unknown@formal@none@1@S@We showed that both IL-10 and IL-4 inhibit LPS-induced IL-6 mRNA and protein expression by inhibiting the transcription rate of the IL-6 gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s369.3) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003376@unknown@formal@none@1@S@The strong inhibition of the IL-6 transcription rate prompted us to study the effect of IL-10 and IL-4 on the expression of transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "prompt") (:form . "prompted") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 145)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s369.4) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003377@unknown@formal@none@1@S@We questioned whether or not IL-10 and IL-4 affected the expression of transcription factors that are known to be involved in the control of the IL-6 transcription rate, namely activator protein-1 (AP-1), nuclear factor IL-6 (NF-IL6), and nuclear factor kappa B (NF-kappaB).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "question") (:form . "questioned") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . 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5003378@unknown@formal@none@1@S@In electrophoretic mobility shift assays (EMSAs) we showed that IL-10 and IL-4 inhibited LPS-induced AP-1 binding activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 58) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s369.6) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003380@unknown@formal@none@1@S@Downregulation of LPS-induced AP-1 was accompanied, and thus possibly explained, by a reduced expression at mRNA level of the two major components of the AP-1 complex, namely c-fos and c-jun as determined by Northern experiments.@(((:tag . "NN") (:stem . "downregulation") (:form . "Downregulation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 174)\n  (:start . 168) (:id . 71))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 180)\n  (:start . 175) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 190)\n  (:start . 185) (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 193) (:start . 191)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 204)\n  (:start . 194) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 216)\n  (:start . 208) (:id . 78))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 228)\n  (:start . 217) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x369.8.1) (:span 61 69)))\n (:hscopes ((:id . :x369.8.1) (:span 61 190)))\n (:identifiers (:sid . :s369.8) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003381@unknown@formal@none@1@S@Binding activity of NF-IL6 was also strongly inhibited by IL-4 whereas IL-10 showed no effect.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 83) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x369.9.1) (:span 84 86)))\n (:nscopes ((:id . :x369.9.1) (:span 84 93)))\n (:identifiers (:sid . :s369.9) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003382@unknown@formal@none@1@S@NF-IL6 mRNA levels were not affected by IL-10 or IL-4, suggesting that IL-4 affects binding activity of preexisting NF-IL6.@(((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "preexist") (:form . "preexisting") (:end . 115)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "nf-il6") (:form . "NF-IL6") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x369.10.1) (:span 55 65)))\n (:ncues ((:id . :x369.10.2) (:span 24 27)))\n (:hscopes ((:id . :x369.10.1) (:span 55 122)))\n (:nscopes ((:id . :x369.10.2) (:span 24 53)))\n (:identifiers (:sid . :s369.10) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003383@unknown@formal@none@1@S@Neither IL-10 nor IL-4 inhibited LPS-induced NF-kappa B binding activity.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x369.11.1) (:span 0 7 14 17)))\n (:nscopes ((:id . :x369.11.1) (:span 0 72)))\n (:identifiers (:sid . :s369.11) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003384@unknown@formal@none@1@S@In agreement with this finding, Northern experiments where p65 and p105 mRNA levels were determined, demonstrated that expression of these components of the NF-kappa B transcription factor were not affected by IL-10 or IL-4.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 113)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 181) (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 188)\n  (:start . 182) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 206)\n  (:start . 198) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 209) (:start . 207)\n  (:id . 74))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 215)\n  (:start . 210) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 218) (:start . 216)\n  (:id . 76))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 223) (:start . 219)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x369.12.1) (:span 194 197)))\n (:nscopes ((:id . :x369.12.1) (:span 119 223)))\n (:identifiers (:sid . :s369.12) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003385@unknown@formal@none@1@S@Furthermore, neither IL-10 nor IL-4 showed any effect on I-kappa B mRNA expression as determined by Northern experiments.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 42) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "I-kappa") (:form . "I-kappa") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x369.13.1) (:span 13 20 27 30)))\n (:nscopes ((:id . :x369.13.1) (:span 13 82)))\n (:identifiers (:sid . :s369.13) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003386@unknown@formal@none@1@S@Thus, IL-10 and IL-4 similarly affect IL-6 expression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s369.14) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003387@unknown@formal@none@1@S@However, for IL-4 this was accompanied with a reduction of AP-1 and NF-IL6 binding activity whereas IL-10 only inhibited AP-1 binding activity.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s369.15) (:did . :|96320604|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003388@unknown@formal@none@1@S@Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "amp") (:form . "AMP") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s370.1) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003390@unknown@formal@none@1@S@The regulation of transcription factors belonging to the signal transducer and activator of transcription (STAT) family was analyzed in PHA-activated mononuclear cells and in purified T cells activated by cross-linking cell surface CD3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pha-activated") (:form . "PHA-activated")\n  (:end . 149) (:start . 136) (:id . 63))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 161)\n  (:start . 150) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 183)\n  (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 70))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 201)\n  (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 218) (:start . 205) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 231)\n  (:start . 224) (:id . 75))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 235) (:start . 232)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s370.3) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003391@unknown@formal@none@1@S@Cell activation resulted in a delayed induction of STAT DNA-binding activity, which was sustained for several days, was composed predominantly of Stat1 and Stat3, and was blocked by cycloheximide and actinomycin D.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 142) (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Stat1") (:form . "Stat1") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Stat3") (:form . "Stat3") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 195) (:start . 182) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 211)\n  (:start . 200) (:id . 75))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 213) (:start . 212)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s370.4) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003392@unknown@formal@none@1@S@Increased Stat1 and Stat3 mRNA and protein levels were detected, respectively 4 and 24 h after activation.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 77)\n  (:start . 65) (:id . 53))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s370.5) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003393@unknown@formal@none@1@S@Stimulation of the cAMP signal transduction pathway, which skews cytokine production toward a Th2 pattern, resulted in the preferential suppression of Stat1 activity.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "skew") (:form . "skews") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "preferential") (:form . "preferential") (:end . 135)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 156)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s370.6) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003394@unknown@formal@none@1@S@cAMP inhibited the induction of expression of IL-2 receptor components, but did not inhibit IL-4 receptor alpha-chain and CD69 expression or the induction of activator protein 1 transcription factors.@(((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cd69") (:form . "CD69") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 175)\n  (:start . 168) (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 199)\n  (:start . 192) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x370.7.1) (:span 80 83)))\n (:nscopes ((:id . :x370.7.1) (:span 80 199)))\n (:identifiers (:sid . :s370.7) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003395@unknown@formal@none@1@S@cAMP signaling inhibited Stat1 at several different levels, including suppression of DNA binding and down-regulation of Stat1 protein and mRNA levels.@(((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 116) (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s370.8) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003396@unknown@formal@none@1@S@Our results demonstrate the regulation of STAT activity by a signaling pathway that regulates the T cell functional phenotype and is distinct from the cytokine-activated Janus kinase-STAT signaling pathway.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cytokine-activated") (:form . "cytokine-activated")\n  (:end . 169) (:start . 151) (:id . 66))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 175)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "kinase-stat") (:form . "kinase-STAT") (:end . 187)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 197)\n  (:start . 188) (:id . 69))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 205)\n  (:start . 198) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s370.9) (:did . :|96322726|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003397@unknown@formal@none@1@S@oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.@(((:tag . "NNP") (:stem . "oriP") (:form . "oriP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "virus-immortalized") (:form . "virus-immortalized")\n  (:end . 84) (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 99) (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 110)\n  (:start . 105) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s371.1) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003398@unknown@formal@none@1@S@During Epstein-Barr virus latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities are mutually exclusive.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNPS") (:stem . "EBNA") (:form . "EBNAs") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 144)\n  (:start . 135) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 161)\n  (:start . 156) (:id . 72))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 172)\n  (:start . 162) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 176) (:start . 173)\n  (:id . 74))\n ((:tag . "RB") (:stem . "mutually") (:form . "mutually") (:end . 185)\n  (:start . 177) (:id . 75))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 195)\n  (:start . 186) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s371.2) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003400@unknown@formal@none@1@S@In this study, the region upstream of Cp was analyzed for the presence of cis elements involved in regulating the activities of the EBNA gene promoters in established in vitro immortalized lymphoblastoid cell lines (LCLs).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 53)\n  (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 86)\n  (:start . 78) (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 109)\n  (:start . 99) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 141) (:start . 137)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 151)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 166)\n  (:start . 155) (:id . 70))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . "VBN") (:stem . "immortalize") (:form . "immortalized") (:end . 188)\n  (:start . 176) (:id . 73))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 203) (:start . 189) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 214)\n  (:start . 209) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCLs") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 221) (:start . 220)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s371.4) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003401@unknown@formal@none@1@S@It was determined that oriP, the origin for episomal maintenance during latency, is essential for efficient transcription initiation from either Cp or Wp in LCLs, as well as in some Burkitt 's lymphoma cell lines.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "oriP") (:form . "oriP") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "episomal") (:form . "episomal") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCLs") (:end . 161) (:start . 157)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 170) (:start . 166)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 73))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 181) (:start . 177)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 189)\n  (:start . 182) (:id . 75))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 192) (:start . 190)\n  (:id . 76))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 201)\n  (:start . 193) (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 206) (:start . 202)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 212)\n  (:start . 207) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s371.5) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003402@unknown@formal@none@1@S@Deletion of the EBNA2-dependent enhancer located upstream of Cp resulted in a ca. two- to fivefold reduction in Cp activity in the LCLs assayed.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ebna2-dependent") (:form . "EBNA2-dependent")\n  (:end . 31) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "FW") (:stem . "ca.") (:form . "ca.") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "fivefold") (:form . "fivefold") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCLs") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s371.6) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003403@unknown@formal@none@1@S@More extensive deletion of sequences upstream of Cp, including the EBNA2-dependent enhancer, resulted in nearly complete loss of Cp activity.@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ebna2-dependent") (:form . "EBNA2-dependent")\n  (:end . 82) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s371.7) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5003406@unknown@formal@none@1@S@Deletion of the glucocorticoid response elements located at ca. bp -850 upstream of Cp did not result in a significant loss in activity.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "FW") (:stem . "ca.") (:form . "ca.") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-850") (:form . "-850") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 118)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x371.10.1) (:span 91 94)))\n (:nscopes ((:id . :x371.10.1) (:span 91 135)))\n (:identifiers (:sid . :s371.10) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003407@unknown@formal@none@1@S@In general, deletions which diminished Cp activity resulted in induction of Wp activity, consistent with suppression of Wp activity by transcriptional interference from Cp.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 116)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 150) (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 163)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s371.11) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003408@unknown@formal@none@1@S@The identification of oriP and the EBNA2-dependent enhancer as the major positive cis elements involved in regulating Cp activity in LCL suggests that EBNA gene transcription is largely autoregulated by EBNA 1 and EBNA 2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "oriP") (:form . "oriP") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ebna2-dependent") (:form . "EBNA2-dependent")\n  (:end . 50) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "cp") (:form . "Cp") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCL") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 174) (:start . 161) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "VBN") (:stem . "autoregulate") (:form . "autoregulated")\n  (:end . 199) (:start . 186) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 218) (:start . 214)\n  (:id . 75))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x371.12.1) (:span 137 145)))\n (:hscopes ((:id . :x371.12.1) (:span 137 220)))\n (:identifiers (:sid . :s371.12) (:did . :|96323085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003410@unknown@formal@none@1@S@The transcriptionally regulatory regions of the lymphomagenic Akv and SL3-3 murine leukemia retroviruses (MLVs) contain two types of E-box consensus motifs, CAGATG.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphomagenic") (:form . "lymphomagenic")\n  (:end . 61) (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "Akv") (:form . "Akv") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SL3-3") (:form . "SL3-3") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NNS") (:stem . "retrovirus") (:form . "retroviruses") (:end . 104)\n  (:start . 92) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 55))\n ((:tag . "NNPS") (:stem . "MLV") (:form . "MLVs") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "e-box") (:form . "E-box") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CAGATG") (:form . "CAGATG") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s372.2) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003411@unknown@formal@none@1@S@One type, EA/S, is located in the upstream promoter region, and the other, E(gre), is located in a tandem repeat with enhancer properties.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "EA/S") (:form . "EA/S") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 26)\n  (:start . 19) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 42)\n  (:start . 34) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "E(gre)") (:form . "E(gre)") (:end . 81)\n  (:start . 75) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 93)\n  (:start . 86) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 105)\n  (:start . 99) (:id . 65))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 112)\n  (:start . 106) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 67))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 126)\n  (:start . 118) (:id . 68))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 137)\n  (:start . 127) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s372.3) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003412@unknown@formal@none@1@S@We have examined the requirements of the individual E-boxes in MLV transcriptional regulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "e-box") (:form . "E-boxes") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MLV") (:form . "MLV") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 82) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s372.4) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003413@unknown@formal@none@1@S@In lymphoid cell lines only, the E(gre)-binding protein complexes included ALF1 or HEB and E2A basic helix-loop-helix proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "E(gre)-binding") (:form . "E(gre)-binding")\n  (:end . 47) (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "ALF1") (:form . "ALF1") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HEB") (:form . "HEB") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 117) (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s372.5) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003414@unknown@formal@none@1@S@Ectopic ALF1 and E2A proteins required intact E(gre) motifs for mediating transcriptional activation.@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "ALF1") (:form . "ALF1") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "E(gre)") (:form . "E(gre)") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 89) (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s372.6) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003415@unknown@formal@none@1@S@ALF1 transactivated transcription of Akv MLV through the two E(gre) motifs equally, whereas E2A protein required the promoter-proximal E(gre) motif.@(((:tag . "NN") (:stem . "alf1") (:form . "ALF1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 33) (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Akv") (:form . "Akv") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MLV") (:form . "MLV") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "E(gre)") (:form . "E(gre)") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "RB") (:stem . "equally") (:form . "equally") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "promoter-proximal") (:form . "promoter-proximal")\n  (:end . 134) (:start . 117) (:id . 60))\n ((:tag . "JJ") (:stem . "E(gre)") (:form . "E(gre)") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s372.7) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003416@unknown@formal@none@1@S@In T- and B-cell lines, the E(gre) motifs were of major importance for Akv MLV transcriptional activity, while the EA/S motif had some effect.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-") (:form . "T-") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "E(gre)") (:form . "E(gre)") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 41)\n  (:start . 35) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 66)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Akv") (:form . "Akv") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MLV") (:form . "MLV") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 94) (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "EA/S") (:form . "EA/S") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 141)\n  (:start . 135) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s372.8) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003417@unknown@formal@none@1@S@In contrast, neither E(gre) nor EA/S motifs contributed pronouncedly to Akv MLV transcription in NIH 3T3 cells lacking DNA-binding ALF1 or HEB and E2A proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "E(gre)") (:form . "E(gre)") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EA/S") (:form . "EA/S") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "VBD") (:stem . "contribute") (:form . "contributed") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "RB") (:stem . "pronouncedly") (:form . "pronouncedly") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Akv") (:form . "Akv") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MLV") (:form . "MLV") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NIH") (:form . "NIH") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "3t3") (:form . "3T3") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "NNP") (:stem . "ALF1") (:form . "ALF1") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HEB") (:form . "HEB") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x372.9.1) (:span 111 118))\n  ((:id . :x372.9.2) (:span 13 20 28 31)))\n (:nscopes ((:id . :x372.9.1) (:span 111 159))\n  ((:id . :x372.9.2) (:span 13 159)))\n (:identifiers (:sid . :s372.9) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003418@unknown@formal@none@1@S@The Id1 protein was found to repress ALF1 activity in vitro and in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "id1") (:form . "Id1") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "alf1") (:form . "ALF1") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s372.10) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003420@unknown@formal@none@1@S@In conclusion, E(gre) motifs and interacting basic helix-loop-helix proteins are important determinants for MLV transcriptional activity in lymphocytic cell lines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "E(gre)") (:form . "E(gre)") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 67) (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 103)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MLV") (:form . "MLV") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 127) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 151)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 156) (:start . 152)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 162)\n  (:start . 157) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s372.12) (:did . :|96323103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003421@unknown@formal@none@1@S@The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 58) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 74) (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "Rex") (:form . "Rex") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "export") (:form . "export") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s373.1) (:did . :|96323172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003422@unknown@formal@none@1@S@The Rex protein of human T-cell leukemia virus type 1 is required for the nuclear export of unspliced viral mRNA and , therefore , for virus replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Rex") (:form . "Rex") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "export") (:form . "export") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unspliced") (:form . "unspliced") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 152)\n  (:start . 141) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s373.2) (:did . :|96323172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003423@unknown@formal@none@1@S@In this manuscript, we demonstrate that Rex shuttles between the nucleus and the cytoplasm and that its activation domain constitutes a nuclear export signal that specifies efficient transport to the cytoplasm.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "manuscript") (:form . "manuscript") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Rex") (:form . "Rex") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "shuttle") (:form . "shuttles") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "VBZ") (:stem . "constitute") (:form . "constitutes") (:end . 133)\n  (:start . 122) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "export") (:form . "export") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 162) (:start . 158)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "specify") (:form . "specifies") (:end . 172)\n  (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 182)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "transport") (:form . "transport") (:end . 192)\n  (:start . 183) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 209)\n  (:start . 200) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s373.3) (:did . :|96323172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003424@unknown@formal@none@1@S@These findings are consistent with a model for Rex-mediated trans-activation in which Rex-viral mRNA complexes are targeted for nuclear export by the direct action of the activation domain.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rex-mediated") (:form . "Rex-mediated") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 76) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "rex-viral") (:form . "Rex-viral") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "export") (:form . "export") (:end . 142)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 156)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 181)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s373.4) (:did . :|96323172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003425@unknown@formal@none@1@S@Multiple p21ras effector pathways regulate nuclear factor of activated T cells.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s374.1) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003426@unknown@formal@none@1@S@The transcription factor, Nuclear Factor of Activated T cells (NFAT) is a major target for p21ras and calcium signalling pathways in the IL-2 gene and is induced by p21ras signals acting in synergy with calcium/calcineurin signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "Factor") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 97)\n  (:start . 91) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 120)\n  (:start . 110) (:id . 63))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 141) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 161)\n  (:start . 154) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 171)\n  (:start . 165) (:id . 73))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 179)\n  (:start . 172) (:id . 74))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 186)\n  (:start . 180) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 76))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 197)\n  (:start . 190) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 202) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "calcium/calcineurin")\n  (:form . "calcium/calcineurin") (:end . 222) (:start . 203) (:id . 79))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 230)\n  (:start . 223) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s374.2) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003427@unknown@formal@none@1@S@One p21ras effector pathway involves the MAP kinase ERK-2, and we have examined its role in NFAT regulation.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "ERK-2") (:form . "ERK-2") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s374.3) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003428@unknown@formal@none@1@S@Expression of dominant negative MAPKK-1 prevents NFAT induction.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "mapkk-1") (:form . "MAPKK-1") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s374.4) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003430@unknown@formal@none@1@S@Expression of dominant negative N17Rac alsoprevents TCR and p21ras activation of NFAT, but without interfering with the ERK-2 pathway.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "N17Rac") (:form . "N17Rac") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "alsoprevent") (:form . "alsoprevents") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "erk-2") (:form . "ERK-2") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x374.6.1) (:span 91 98)))\n (:nscopes ((:id . :x374.6.1) (:span 91 133)))\n (:identifiers (:sid . :s374.6) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003431@unknown@formal@none@1@S@The transcriptional activity of the NFAT binding site is mediated by a complex comprising a member of the NFAT group and AP-1 family proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "VBG") (:stem . "comprise") (:form . "comprising") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s374.7) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003432@unknown@formal@none@1@S@The induction of AP-1 by p21ras alsorequires Rac-1 function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "alsorequire") (:form . "alsorequires") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s374.8) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003433@unknown@formal@none@1@S@Activated Rac-1 could mimic activated p21ras to induce AP-1 but not to induce NFAT.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x374.9.2) (:span 16 21)))\n (:ncues ((:id . :x374.9.1) (:span 64 67)))\n (:hscopes ((:id . :x374.9.2) (:span 16 82)))\n (:nscopes ((:id . :x374.9.1) (:span 64 82)))\n (:identifiers (:sid . :s374.9) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003434@unknown@formal@none@1@S@Moreover, the combination of activated MAPKK-1 and Rac-1 could not substitute for activated p21ras and synergize with calcium signals to induce NFAT.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "mapkk-1") (:form . "MAPKK-1") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x374.10.1) (:span 57 66)))\n (:nscopes ((:id . :x374.10.1) (:span 57 148)))\n (:identifiers (:sid . :s374.10) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003435@unknown@formal@none@1@S@Thus, p21ras regulation of NFAT in T cells requires the activity of multiple effector pathways including those regulated by MAPKK-1/ERK-2 and Rac-1.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mapkk-1/erk-2") (:form . "MAPKK-1/ERK-2")\n  (:end . 137) (:start . 124) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s374.11) (:did . :|96324400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003436@unknown@formal@none@1@S@Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.@(((:tag . "NNP") (:stem . "Protein-tyrosine") (:form . "Protein-tyrosine")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 23)\n  (:start . 17) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 69) (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 79)\n  (:start . 70) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 94)\n  (:start . 83) (:id . 51))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 100) (:start . 95)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nfkappab") (:form . "NFkappaB") (:end . 113)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 129) (:start . 126)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 133) (:start . 130)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 142)\n  (:start . 134) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 150)\n  (:start . 143) (:id . 60))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 164) (:start . 151) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x375.1.1) (:span 130 133)))\n (:nscopes ((:id . :x375.1.1) (:span 130 164)))\n (:identifiers (:sid . :s375.1) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003437@unknown@formal@none@1@S@In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 133) (:start . 115) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 148) (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 187) (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 206)\n  (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 212)\n  (:start . 207) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 217) (:start . 213)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s375.2) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003438@unknown@formal@none@1@S@Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 177) (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 184)\n  (:start . 178) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 194)\n  (:start . 186) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s375.3) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003440@unknown@formal@none@1@S@We have found that , in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pro-monocytic") (:form . "pro-monocytic")\n  (:end . 47) (:start . 34) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "THP-1") (:form . "THP-1") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 96) (:start . 70) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 141)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 160)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 171)\n  (:start . 161) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s375.5) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003441@unknown@formal@none@1@S@Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-mediated")\n  (:form . "lipopolysaccharide-mediated") (:end . 65) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 87) (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 99)\n  (:start . 91) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x375.6.1) (:span 21 24)))\n (:nscopes ((:id . :x375.6.1) (:span 21 99)))\n (:identifiers (:sid . :s375.6) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003442@unknown@formal@none@1@S@However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s375.7) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003443@unknown@formal@none@1@S@This inhibition of transcription is specific for NFkappaB;@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 58) (:start . 57)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s375.8) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003444@unknown@formal@none@1@S@in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.@(((:tag . "IN") (:stem . "in") (:form . "in") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ap-1-dependent") (:form . "AP-1-dependent")\n  (:end . 58) (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s375.9) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003445@unknown@formal@none@1@S@These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 60) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 87)\n  (:start . 75) (:id . 51))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 97)\n  (:start . 88) (:id . 52))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 106)\n  (:start . 98) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 115)\n  (:start . 107) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 122)\n  (:start . 116) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 131)\n  (:start . 123) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 141)\n  (:start . 133) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 148)\n  (:start . 142) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 157)\n  (:start . 149) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 160) (:start . 158)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 164) (:start . 161)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 175)\n  (:start . 165) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 198) (:start . 180) (:id . 65))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 205)\n  (:start . 199) (:id . 66))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 218)\n  (:start . 206) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x375.10.2) (:span 14 21)))\n (:ncues ((:id . :x375.10.1) (:span 161 164)))\n (:hscopes ((:id . :x375.10.2) (:span 14 218)))\n (:nscopes ((:id . :x375.10.1) (:span 161 218)))\n (:identifiers (:sid . :s375.10) (:did . :|96324890|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003446@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 63) (:start . 49) (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 73)\n  (:start . 64) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "94-kd") (:form . "94-kD") (:end . 83) (:start . 78)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 90)\n  (:start . 84) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "80-kd") (:form . "80-kD") (:end . 103) (:start . 98)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 110)\n  (:start . 104) (:id . 53))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 118)\n  (:start . 111) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 138)\n  (:start . 128) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 144)\n  (:start . 139) (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 154)\n  (:start . 145) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s376.1) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003447@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces immediate effects in monocytes by activation of the Janus kinase (JAK2) and STAT transcription factor (STAT5) pathway.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 56)\n  (:start . 50) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 75)\n  (:start . 66) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 83)\n  (:start . 76) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "JAK2") (:form . "JAK2") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 160) (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s376.2) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003448@unknown@formal@none@1@S@Recent studies have identified homologues of STAT5, STAT5A, and STAT5B, as well as lower molecular weight variants of STAT5.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "homologue") (:form . "homologues") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s376.3) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003450@unknown@formal@none@1@S@Freshly isolated monocytes expressed 94-kD STAT5A, 92-kD STAT5B, and an 80-kD STAT5A molecule.@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "94-kd") (:form . "94-kD") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "92-kd") (:form . "92-kD") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "80-kd") (:form . "80-kD") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s376.5) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003451@unknown@formal@none@1@S@Whereas 94-kD STAT5A was clearly tyrosine phosphorylated and bound to the enhancer element, the gamma response region (GRR), of the Fc gamma RI gene, substantially less tyrosine phosphorylated STAT5B bound to the immobilized GRR element.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "94-kd") (:form . "94-kD") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 56) (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GRR") (:form . "GRR") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 163) (:start . 150) (:id . 71))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 177)\n  (:start . 169) (:id . 73))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 192) (:start . 178) (:id . 74))\n ((:tag . "NN") (:stem . "stat5b") (:form . "STAT5B") (:end . 199)\n  (:start . 193) (:id . 75))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 205)\n  (:start . 200) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "immobilize") (:form . "immobilized") (:end . 224)\n  (:start . 213) (:id . 79))\n ((:tag . "NN") (:stem . "grr") (:form . "GRR") (:end . 228) (:start . 225)\n  (:id . 80))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 236)\n  (:start . 229) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s376.6) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003452@unknown@formal@none@1@S@Macrophages lost their ability to express the 80-kD STAT5A protein, but retained their ability to activate STAT5A.@(((:tag . "NNP") (:stem . "Macrophage") (:form . "Macrophages") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "lose") (:form . "lost") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 22)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "80-kd") (:form . "80-kD") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "retain") (:form . "retained") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s376.7) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003453@unknown@formal@none@1@S@STAT5A-STAT5A homodimers and STAT5A-STAT5B heterodimers formed in response to GM-CSF.@(((:tag . "NNP") (:stem . "STAT5A-STAT5A") (:form . "STAT5A-STAT5A")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stat5a-stat5b") (:form . "STAT5A-STAT5B")\n  (:end . 42) (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 55)\n  (:start . 43) (:id . 46))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 62) (:start . 56)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 84)\n  (:start . 78) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s376.8) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003454@unknown@formal@none@1@S@Therefore, activation of STAT5A predominates compared to STAT5B when assayed by direct immunoprecipitation and by evaluation of bound STATs to immobilized GRR.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "predominate") (:form . "predominates") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 106) (:start . 87) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immobilized") (:form . "immobilized") (:end . 154)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "grr") (:form . "GRR") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s376.9) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003455@unknown@formal@none@1@S@Selective activation of STAT5 homologues in addition to generation of lower molecular isoforms may provide specificity and control to genes expressed in response to cytokines such as GM-CSF.@(((:tag . "JJ") (:stem . "selective") (:form . "Selective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "homologue") (:form . "homologues") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 118)\n  (:start . 107) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 161)\n  (:start . 153) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 174)\n  (:start . 165) (:id . 66))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 179) (:start . 175)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 189)\n  (:start . 183) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x376.10.1) (:span 95 98)))\n (:hscopes ((:id . :x376.10.1) (:span 95 189)))\n (:identifiers (:sid . :s376.10) (:did . :|96329553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003456@unknown@formal@none@1@S@LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.@(((:tag . "JJ") (:stem . "lysp100-associated") (:form . "LYSP100-associated")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 26)\n  (:start . 19) (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 34)\n  (:start . 27) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LAND") (:form . "LANDs") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "description") (:form . "description") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "subnuclear") (:form . "subnuclear") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 118)\n  (:start . 106) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pml") (:form . "PML") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 140)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s377.1) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003457@unknown@formal@none@1@S@The PML gene is fused to the retinoic acid receptor alpha (RAR alpha) gene in t(15;17) acute promyelocytic leukemia (APL), creating a PML-RAR alpha fusion oncoprotein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "t(15;17)") (:form . "t(15;17)") (:end . 86)\n  (:start . 78) (:id . 59))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 92) (:start . 87)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 106) (:start . 93) (:id . 61))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "create") (:form . "creating") (:end . 131)\n  (:start . 123) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pml-rar") (:form . "PML-RAR") (:end . 141)\n  (:start . 134) (:id . 69))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 147)\n  (:start . 142) (:id . 70))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 154)\n  (:start . 148) (:id . 71))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 166)\n  (:start . 155) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s377.2) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003458@unknown@formal@none@1@S@The PML gene product has been localized to subnuclear dot-like structures variously termed PODs, ND10s, Kr bodies, or PML nuclear bodies (PML NBs).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "subnuclear") (:form . "subnuclear") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "dot-like") (:form . "dot-like") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "variously") (:form . "variously") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 90) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "POD") (:form . "PODs") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ND10") (:form . "ND10s") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Kr") (:form . "Kr") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NB") (:form . "NBs") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s377.3) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003460@unknown@formal@none@1@S@In addition to SP100 homology regions, one LYSP100 cDNA isoform contains a bromodomain and a PHD/TTC domain, which are present in a variety of transcriptional regulatory proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sp100") (:form . "SP100") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lysp100") (:form . "LYSP100") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bromodomain") (:form . "bromodomain") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PHD/TTC") (:form . "PHD/TTC") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 158) (:start . 143) (:id . 68))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 169)\n  (:start . 159) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s377.5) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003461@unknown@formal@none@1@S@By immunofluorescence, LYSP100 was localized to nuclear dots that were surprisingly largely nonoverlapping with PML NBs.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 21) (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LYSP100") (:form . "LYSP100") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "dot") (:form . "dots") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "surprisingly") (:form . "surprisingly") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "JJ") (:stem . "nonoverlapping") (:form . "nonoverlapping")\n  (:end . 106) (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NB") (:form . "NBs") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s377.6) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003462@unknown@formal@none@1@S@However, a minority of LYSP100 nuclear dots exactly colocalized with PML and SP100.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "minority") (:form . "minority") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lysp100") (:form . "LYSP100") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "dot") (:form . "dots") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "colocalize") (:form . "colocalized") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SP100") (:form . "SP100") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s377.7) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003463@unknown@formal@none@1@S@We term the LYSP100 structures "LANDs, " for LYSP100-associated nuclear domains.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "term") (:form . "term") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lysp100") (:form . "LYSP100") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "structure") (:form . "structures") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "\\"LANDs") (:form . "\\"LANDs") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lysp100-associated") (:form . "LYSP100-associated")\n  (:end . 63) (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s377.8) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003464@unknown@formal@none@1@S@Although LYSP100 is expressed only in lymphoid cells, LANDs could be visualized in HeLa cells by transfection of a LYSP100 cDNA.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "LYSP100") (:form . "LYSP100") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "land") (:form . "LANDs") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "visualize") (:form . "visualized") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LYSP100") (:form . "LYSP100") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s377.9) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003465@unknown@formal@none@1@S@Immunoelectron microscopy revealed LANDs to be globular, electron-dense structures morphologically distinct from the annular structures characteristic of PML NBs.@(((:tag . "NNP") (:stem . "Immunoelectron") (:form . "Immunoelectron")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "NNS") (:stem . "land") (:form . "LANDs") (:end . 40) (:start . 35)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "globular") (:form . "globular") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "electron-dense") (:form . "electron-dense")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "RB") (:stem . "morphologically") (:form . "morphologically")\n  (:end . 98) (:start . 83) (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "annular") (:form . "annular") (:end . 124)\n  (:start . 117) (:id . 56))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 135)\n  (:start . 125) (:id . 57))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 150) (:start . 136) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 157) (:start . 154)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NB") (:form . "NBs") (:end . 161) (:start . 158)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s377.10) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003466@unknown@formal@none@1@S@LANDs were most often found in the nucleoplasm, but were also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus.@(((:tag . "NNS") (:stem . "land") (:form . "LANDs") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nucleoplasm") (:form . "nucleoplasm") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 112)\n  (:start . 103) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 124)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 146)\n  (:start . 136) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "VB") (:stem . "traffic") (:form . "traffic") (:end . 158)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 166)\n  (:start . 159) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 180)\n  (:start . 171) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 196)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x377.11.1) (:span 147 150))\n  ((:id . :x377.11.2) (:span 114 124)))\n (:hscopes ((:id . :x377.11.1) (:span 147 196))\n  ((:id . :x377.11.2) (:span 114 196)))\n (:identifiers (:sid . :s377.11) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003467@unknown@formal@none@1@S@By double-immunogold labeling of PML and LYSP100, some LANDs were shown to contain both PML and LYSP100.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "double-immunogold") (:form . "double-immunogold")\n  (:end . 20) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "labeling") (:form . "labeling") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LYSP100") (:form . "LYSP100") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "land") (:form . "LANDs") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LYSP100") (:form . "LYSP100") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s377.12) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003468@unknown@formal@none@1@S@Thus, PML is localized to a second subnuclear domain that is morphologically and biochemically distinct from PML NBs.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 22)\n  (:start . 13) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "JJ") (:stem . "subnuclear") (:form . "subnuclear") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "RB") (:stem . "morphologically") (:form . "morphologically")\n  (:end . 76) (:start . 61) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "biochemically") (:form . "biochemically")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NB") (:form . "NBs") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s377.13) (:did . :|96329578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003470@unknown@formal@none@1@S@Abnormalities in the p16, p15 and CDK4 genes that regulate transition through the G1 phase of the cell cycle have been implicated in the malignant progression of astrocytomas.@(((:tag . "NNS") (:stem . "abnormality") (:form . "Abnormalities") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p15") (:form . "p15") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cdk4") (:form . "CDK4") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 146)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 158)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "astrocytoma") (:form . "astrocytomas") (:end . 174)\n  (:start . 162) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s378.2) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003471@unknown@formal@none@1@S@The results of the present study demonstrate that dysfunction of these genes also occurs during recurrence of glial tumors that were highly malignant at first presentation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dysfunction") (:form . "dysfunction") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "recurrence") (:form . "recurrence") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 171)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s378.3) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003472@unknown@formal@none@1@S@Analysis of 10 matched pairs of high grade malignant astrocytomas and their subsequent recurrences identified three distinct groups.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "match") (:form . "matched") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "grade") (:form . "grade") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "astrocytoma") (:form . "astrocytomas") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 75)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "recurrence") (:form . "recurrences") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 109)\n  (:start . 99) (:id . 56))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s378.4) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003473@unknown@formal@none@1@S@The primary and recurrent tumors in Group A did not show structural alterations in the p16, p15 or CDK4 genes, whereas homozygous codeletion of p16 and p15 was observed in both primary and recurrent tumors in Group B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p15") (:form . "p15") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cdk4") (:form . "CDK4") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 63))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 118)\n  (:start . 111) (:id . 64))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 129)\n  (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "codeletion") (:form . "codeletion") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p15") (:form . "p15") (:end . 155) (:start . 152)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 168)\n  (:start . 160) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 176) (:start . 172)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 184)\n  (:start . 177) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 198)\n  (:start . 189) (:id . 77))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 205)\n  (:start . 199) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 214)\n  (:start . 209) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 216) (:start . 215)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x378.5.1) (:span 48 51)))\n (:nscopes ((:id . :x378.5.1) (:span 48 109)))\n (:identifiers (:sid . :s378.5) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003474@unknown@formal@none@1@S@The primary tumors in Group C had a normal profile of p16, p15 and CDK4 at presentation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p15") (:form . "p15") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cdk4") (:form . "CDK4") (:end . 71) (:start . 67)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 87)\n  (:start . 75) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s378.6) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003475@unknown@formal@none@1@S@Upon recurrence, however, the tumors sustained either deletion of p16 alone or codeletion of both p16 and p15 or amplification of CDK4.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "recurrence") (:form . "recurrence") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "VBD") (:stem . "sustain") (:form . "sustained") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codeletion") (:form . "codeletion") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p15") (:form . "p15") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "amplification") (:form . "amplification")\n  (:end . 126) (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cdk4") (:form . "CDK4") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s378.7) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003476@unknown@formal@none@1@S@Analysis of the molecular differences between primary anaplastic astrocytomas/glioblastomas and their subsequent recurrences, which are clinically indistinguishable, may provide better therapeutic options for treatment.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "JJ") (:stem . "anaplastic") (:form . "anaplastic") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "astrocytomas/glioblastoma")\n  (:form . "astrocytomas/glioblastomas") (:end . 91) (:start . 65) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 101)\n  (:start . 96) (:id . 52))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 112)\n  (:start . 102) (:id . 53))\n ((:tag . "NNS") (:stem . "recurrence") (:form . "recurrences") (:end . 124)\n  (:start . 113) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 57))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 146)\n  (:start . 136) (:id . 58))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 164) (:start . 147) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 169) (:start . 166)\n  (:id . 61))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 177)\n  (:start . 170) (:id . 62))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 184)\n  (:start . 178) (:id . 63))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 196)\n  (:start . 185) (:id . 64))\n ((:tag . "NNS") (:stem . "option") (:form . "options") (:end . 204)\n  (:start . 197) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 208) (:start . 205)\n  (:id . 66))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 218)\n  (:start . 209) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x378.8.1) (:span 166 169)))\n (:hscopes ((:id . :x378.8.1) (:span 166 218)))\n (:identifiers (:sid . :s378.8) (:did . :|96330347|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003477@unknown@formal@none@1@S@CTL recognition of an altered peptide associated with asparagine bond rearrangement.@(((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "asparagine") (:form . "asparagine") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "bond") (:form . "bond") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 83) (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s379.1) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003478@unknown@formal@none@1@S@Implications for immunity and vaccine design.@(((:tag . "NNS") (:stem . "implication") (:form . "Implications") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vaccine") (:form . "vaccine") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s379.2) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003480@unknown@formal@none@1@S@We report on the CTL recognition of a MHC class I-restricted peptide containing a cyclized asparagine (succinimide) residue.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 32)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "i-restricted") (:form . "I-restricted") (:end . 60)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "cyclize") (:form . "cyclized") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "asparagine") (:form . "asparagine") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "succinimide") (:form . "succinimide") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s379.4) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003481@unknown@formal@none@1@S@This modification of the asparagine side chain is a common intermediate structure during deamidation, isomerization, and bond rearrangements of amide-containing amino acids and also occurs as a side reaction in peptide synthesis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "asparagine") (:form . "asparagine") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "deamidation") (:form . "deamidation") (:end . 100)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "isomerization") (:form . "isomerization")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bond") (:form . "bond") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 140) (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "amide-containing") (:form . "amide-containing")\n  (:end . 160) (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 166)\n  (:start . 161) (:id . 64))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 181) (:start . 177)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 188)\n  (:start . 182) (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "side") (:form . "side") (:end . 198) (:start . 194)\n  (:id . 71))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 207)\n  (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 218)\n  (:start . 211) (:id . 74))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 228)\n  (:start . 219) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s379.5) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003482@unknown@formal@none@1@S@The CTL specifically recognized the succinimide-containing peptide showing only weak cross-reactivity at high concentrations of the parent peptide containing unmodified asparagine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "recognize") (:form . "recognized") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "succinimide-containing")\n  (:form . "succinimide-containing") (:end . 58) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 66)\n  (:start . 59) (:id . 48))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 74)\n  (:start . 67) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cross-reactivity") (:form . "cross-reactivity")\n  (:end . 101) (:start . 85) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 109) (:start . 105)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 124) (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 57))\n ((:tag . "NN") (:stem . "parent") (:form . "parent") (:end . 138)\n  (:start . 132) (:id . 58))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 146)\n  (:start . 139) (:id . 59))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 157)\n  (:start . 147) (:id . 60))\n ((:tag . "JJ") (:stem . "unmodified") (:form . "unmodified") (:end . 168)\n  (:start . 158) (:id . 61))\n ((:tag . "NN") (:stem . "asparagine") (:form . "asparagine") (:end . 179)\n  (:start . 169) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s379.6) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003483@unknown@formal@none@1@S@Similarly, CTL raised against the parent peptide did not recognize the succinimide derivative of this peptide.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "parent") (:form . "parent") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "recognize") (:form . "recognize") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "succinimide") (:form . "succinimide") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x379.7.1) (:span 53 56)))\n (:nscopes ((:id . :x379.7.1) (:span 53 109)))\n (:identifiers (:sid . :s379.7) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003484@unknown@formal@none@1@S@Naturally processed forms of these structures are likely to occur given the importance and frequency of deamidation both in vitro and in vivo.@(((:tag . "RB") (:stem . "naturally") (:form . "Naturally") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "process") (:form . "processed") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "deamidation") (:form . "deamidation") (:end . 115)\n  (:start . 104) (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x379.8.1) (:span 50 56)))\n (:hscopes ((:id . :x379.8.1) (:span 0 65)))\n (:identifiers (:sid . :s379.8) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003485@unknown@formal@none@1@S@Moreover, since succinimide intermediates of deamidated peptides can occasionally be very stable, these peptides have the potential to act as altered self-Ags with significant implications for autoimmunity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "succinimide") (:form . "succinimide") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "deamidate") (:form . "deamidated") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "occasionally") (:form . "occasionally") (:end . 81)\n  (:start . 69) (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "self-ag") (:form . "self-Ags") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 175)\n  (:start . 164) (:id . 67))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 188)\n  (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "NN") (:stem . "autoimmunity") (:form . "autoimmunity") (:end . 205)\n  (:start . 193) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x379.9.1) (:span 65 68)))\n (:hscopes ((:id . :x379.9.1) (:span 65 96)))\n (:identifiers (:sid . :s379.9) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003486@unknown@formal@none@1@S@In addition, unwanted and potentially hazardous specificities may be elicited when using synthetic peptides in subunit vaccines in which succinimide residues may form spontaneously during storage or chemical synthesis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unwanted") (:form . "unwanted") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "hazardous") (:form . "hazardous") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "specificity") (:form . "specificities") (:end . 61)\n  (:start . 48) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "vaccine") (:form . "vaccines") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "succinimide") (:form . "succinimide") (:end . 148)\n  (:start . 137) (:id . 62))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 161) (:start . 158)\n  (:id . 64))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 166) (:start . 162)\n  (:id . 65))\n ((:tag . "RB") (:stem . "spontaneously") (:form . "spontaneously")\n  (:end . 180) (:start . 167) (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 187)\n  (:start . 181) (:id . 67))\n ((:tag . "NN") (:stem . "storage") (:form . "storage") (:end . 195)\n  (:start . 188) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "NN") (:stem . "chemical") (:form . "chemical") (:end . 207)\n  (:start . 199) (:id . 70))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 217)\n  (:start . 208) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x379.10.1) (:span 158 161))\n  ((:id . :x379.10.2) (:span 62 65)))\n (:hscopes ((:id . :x379.10.1) (:span 158 217))\n  ((:id . :x379.10.2) (:span 13 217)))\n (:identifiers (:sid . :s379.10) (:did . :|96338163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003487@unknown@formal@none@1@S@[NGFI-B/nur77 family involved in T-cell apoptosis]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NGFI-B/nur77") (:form . "NGFI-B/nur77") (:end . 13)\n  (:start . 1) (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 50) (:start . 49)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s380.1) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003488@unknown@formal@none@1@S@NGFI-B/nur77 is a member of the steroid receptor superfamily.@(((:tag . "NNP") (:stem . "NGFI-B/nur77") (:form . "NGFI-B/nur77") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s380.2) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003490@unknown@formal@none@1@S@We cloned human nur77 beta cDNA, called TINUR.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "clone") (:form . "cloned") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 39) (:start . 33)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TINUR") (:form . "TINUR") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s380.4) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003491@unknown@formal@none@1@S@Although NGFI-B/nur77 is essential for TCR-mediated apoptosis in T-cell hybridomas, the reports on nur77 knock-out mice and nur77 dominant negative transgenic mice suggest that there is a functional redundancy among NGFI-B/nur77 family.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NGFI-B/nur77") (:form . "NGFI-B/nur77") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 61)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "knock-out") (:form . "knock-out") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 119)\n  (:start . 115) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 158)\n  (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 163)\n  (:start . 159) (:id . 64))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 171)\n  (:start . 164) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 176) (:start . 172)\n  (:id . 66))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 182)\n  (:start . 177) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 185) (:start . 183)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 198)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "redundancy") (:form . "redundancy") (:end . 209)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 215)\n  (:start . 210) (:id . 72))\n ((:tag . "NN") (:stem . "ngfi-b/nur77") (:form . "NGFI-B/nur77") (:end . 228)\n  (:start . 216) (:id . 73))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 235)\n  (:start . 229) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x380.5.1) (:span 164 171)))\n (:hscopes ((:id . :x380.5.1) (:span 164 235)))\n (:identifiers (:sid . :s380.5) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003492@unknown@formal@none@1@S@NGFI-B/nur77 binds to the response element by monomer or heterodimer with retinoid X receptor (RXR).@(((:tag . "NNP") (:stem . "NGFI-B/nur77") (:form . "NGFI-B/nur77") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "monomer") (:form . "monomer") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RXR") (:form . "RXR") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s380.6) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003493@unknown@formal@none@1@S@Assuming that 9-cis-retinoic acid (9-cis-RA) inhibits TCR-mediated apoptosis, nur77 may cause apoptosis by monomer in the absence of 9-cis-RA and may inhibit apoptosis by heterodimer with RXR in the presence of 9-cis-RA.@(((:tag . "VBG") (:stem . "assume") (:form . "Assuming") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "9-cis-retinoic") (:form . "9-cis-retinoic")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "9-cis-RA") (:form . "9-cis-RA") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nur77") (:form . "nur77") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "monomer") (:form . "monomer") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "9-cis-RA") (:form . "9-cis-RA") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 182)\n  (:start . 171) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "rxr") (:form . "RXR") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 207)\n  (:start . 199) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "9-cis-RA") (:form . "9-cis-RA") (:end . 219)\n  (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x380.7.1) (:span 146 149))\n  ((:id . :x380.7.2) (:span 84 87)))\n (:hscopes ((:id . :x380.7.1) (:span 146 219))\n  ((:id . :x380.7.2) (:span 84 141)))\n (:identifiers (:sid . :s380.7) (:did . :|96344715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003494@unknown@formal@none@1@S@Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA.@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 76) (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NNP") (:stem . "IIA") (:form . "IIA") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s381.1) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003495@unknown@formal@none@1@S@The Tax protein of human T-cell lymphotropic virus type 1 (HTLV-1) is a 40-kDa transcriptional activator which is critical for HTLV-1 gene regulation and virus-induced cellular transformation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "40-kda") (:form . "40-kDa") (:end . 78)\n  (:start . 72) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 94) (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "virus-induced") (:form . "virus-induced")\n  (:end . 167) (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 191) (:start . 177) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s381.2) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003496@unknown@formal@none@1@S@Tax is localized to the DNA through its interaction with the site-specific activators cyclic AMP-responsive element-binding protein, NF-kappaB, and serum response factor.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 51)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "site-specific") (:form . "site-specific")\n  (:end . 74) (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "amp-responsive") (:form . "AMP-responsive")\n  (:end . 107) (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 123) (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 131)\n  (:start . 124) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 142)\n  (:start . 133) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 169)\n  (:start . 163) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s381.3) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003497@unknown@formal@none@1@S@It has been suggested that the recruitment of Tax to the DNA positions Tax for interaction with the basal transcriptional machinery.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 121) (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x381.4.1) (:span 12 21)))\n (:hscopes ((:id . :x381.4.1) (:span 12 131)))\n (:identifiers (:sid . :s381.4) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003498@unknown@formal@none@1@S@On the basis of several independent assays, we now report a physical and functional interaction between Tax and the transcription factor, TFIIA.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s381.5) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003500@unknown@formal@none@1@S@Importantly, two previously characterized mutants with point mutations in Tax, M32 (Y196A, K197S) and M41 (H287A, P288S), which were shown to be defective in Tax-activated transcription were unable to interact with TFIIA in this assay.@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "M32") (:form . "M32") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Y196A") (:form . "Y196A") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "K197S") (:form . "K197S") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "M41") (:form . "M41") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "H287A") (:form . "H287A") (:end . 112)\n  (:start . 107) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "P288S") (:form . "P288S") (:end . 119)\n  (:start . 114) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 132) (:start . 128)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 138)\n  (:start . 133) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 144) (:start . 142)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 154)\n  (:start . 145) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "tax-activated") (:form . "Tax-activated")\n  (:end . 171) (:start . 158) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 185) (:start . 172) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 190) (:start . 186)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 197)\n  (:start . 191) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 79))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 209)\n  (:start . 201) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 214) (:start . 210)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 220)\n  (:start . 215) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 83))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 228) (:start . 224)\n  (:id . 84))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 234)\n  (:start . 229) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x381.7.1) (:span 191 197)))\n (:nscopes ((:id . :x381.7.1) (:span 191 234)))\n (:identifiers (:sid . :s381.7) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003501@unknown@formal@none@1@S@Second, a glutathione-S-transferase (GST) affinity-binding assay showed that the interaction of holo-TFIIA with GST-Tax was 20-fold higher than that observed with either the GST-Tax M32 activation mutant or the GST control.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glutathione-s-transferase")\n  (:form . "glutathione-S-transferase") (:end . 35) (:start . 10) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GST") (:form . "GST") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "affinity-binding") (:form . "affinity-binding")\n  (:end . 58) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 71) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "holo-TFIIA") (:form . "holo-TFIIA") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GST-Tax") (:form . "GST-Tax") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "RB") (:stem . "20-fold") (:form . "20-fold") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 169)\n  (:start . 163) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GST-Tax") (:form . "GST-Tax") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . "NNP") (:stem . "M32") (:form . "M32") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 196)\n  (:start . 186) (:id . 70))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 203)\n  (:start . 197) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 206) (:start . 204)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "GST") (:form . "GST") (:end . 214) (:start . 211)\n  (:id . 74))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 222)\n  (:start . 215) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s381.8) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003502@unknown@formal@none@1@S@Third, a coimmunoprecipitation assay showed that in HTLV-1-infected human T lymphocytes, Tax and TFIIA were associated.@(((:tag . "RB") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "coimmunoprecipitation")\n  (:form . "coimmunoprecipitation") (:end . 30) (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 43) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "htlv-1-infected") (:form . "HTLV-1-infected")\n  (:end . 67) (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s381.9) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003503@unknown@formal@none@1@S@Finally, TFIIA facilitates Tax transactivation in vitro and in vivo.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "facilitate") (:form . "facilitates") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s381.10) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003504@unknown@formal@none@1@S@In vitro transcription studies showed reduced levels of Tax-activated transcription in cell extracts depleted of TFIIA.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 37) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "tax-activated") (:form . "Tax-activated")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "VBN") (:stem . "deplete") (:form . "depleted") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s381.11) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003505@unknown@formal@none@1@S@In addition, transfection of human T lymphocytes with TFIIA expression vectors enhanced Tax-activated transcription of an HTLV-1 long terminal repeat-chloramphenicol acetyltransferase reporter construct.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "tax-activated") (:form . "Tax-activated")\n  (:end . 101) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "repeat-chloramphenicol")\n  (:form . "repeat-chloramphenicol") (:end . 165) (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 183) (:start . 166) (:id . 63))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 192)\n  (:start . 184) (:id . 64))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 202)\n  (:start . 193) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s381.12) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003506@unknown@formal@none@1@S@Our study suggests that the interaction of Tax with the transcription factor TFIIA may play a role in Tax-mediated transcriptional activation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "TFIIA") (:form . "TFIIA") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "tax-mediated") (:form . "Tax-mediated") (:end . 114)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 130) (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x381.13.1) (:span 83 86))\n  ((:id . :x381.13.2) (:span 10 18)))\n (:hscopes ((:id . :x381.13.1) (:span 83 141))\n  ((:id . :x381.13.2) (:span 10 141)))\n (:identifiers (:sid . :s381.13) (:did . :|96347533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003507@unknown@formal@none@1@S@Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.@(((:tag . "NNP") (:stem . "Peptide") (:form . "Peptide") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "vaccination") (:form . "vaccination") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x382.1.1) (:span 20 23)))\n (:hscopes ((:id . :x382.1.1) (:span 20 97)))\n (:identifiers (:sid . :s382.1) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003508@unknown@formal@none@1@S@Vaccination with synthetic peptides representing cytotoxic T lymphocyte (CTL) epitopes can lead to a protective CTL-mediated immunity against tumors or viruses.@(((:tag . "NN") (:stem . "vaccination") (:form . "Vaccination") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 48)\n  (:start . 36) (:id . 46))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 58)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "ctl-mediated") (:form . "CTL-mediated") (:end . 124)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 148)\n  (:start . 142) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x382.2.1) (:span 87 90)))\n (:hscopes ((:id . :x382.2.1) (:span 87 159)))\n (:identifiers (:sid . :s382.2) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003510@unknown@formal@none@1@S@This adverse effect of peptide vaccination was rapidly evoked, required low doses of peptide (10 micrograms), and was achieved by a mode of peptide delivery that induces protective T-cell-mediated immunity in other models.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adverse") (:form . "adverse") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "vaccination") (:form . "vaccination") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "VBN") (:stem . "evoke") (:form . "evoked") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "microgram") (:form . "micrograms") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 136) (:start . 132)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 147)\n  (:start . 140) (:id . 69))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 156)\n  (:start . 148) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 169)\n  (:start . 162) (:id . 72))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 180)\n  (:start . 170) (:id . 73))\n ((:tag . "JJ") (:stem . "t-cell-mediated") (:form . "T-cell-mediated")\n  (:end . 196) (:start . 181) (:id . 74))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 205)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 214)\n  (:start . 209) (:id . 77))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 221)\n  (:start . 215) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s382.4) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003511@unknown@formal@none@1@S@Ad5E1A-specific CTL activity could no longer be isolated from mice after injection of Ad5E1A-peptide, indicating that tolerization of Ad5E1A-specific CTL activity causes the enhanced tumor outgrowth.@(((:tag . "JJ") (:stem . "ad5e1a-specific") (:form . "Ad5E1A-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "no") (:form . "no") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "RB") (:stem . "longer") (:form . "longer") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ad5E1A-peptide") (:form . "Ad5E1A-peptide")\n  (:end . 100) (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tolerization") (:form . "tolerization") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ad5e1a-specific") (:form . "Ad5E1A-specific")\n  (:end . 149) (:start . 134) (:id . 61))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 162)\n  (:start . 154) (:id . 63))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 169)\n  (:start . 163) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 182)\n  (:start . 174) (:id . 66))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 188)\n  (:start . 183) (:id . 67))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 198)\n  (:start . 189) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x382.5.1) (:span 102 117)))\n (:ncues ((:id . :x382.5.2) (:span 35 44)))\n (:hscopes ((:id . :x382.5.1) (:span 102 198)))\n (:nscopes ((:id . :x382.5.2) (:span 0 100)))\n (:identifiers (:sid . :s382.5) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003512@unknown@formal@none@1@S@In contrast to peptide vaccination, immunization with adenovirus, expressing Ad5E1A, induced Ad5E1A-specific immunity and prevented the outgrowth of Ad5E1A-expressing tumors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "vaccination") (:form . "vaccination") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunization") (:form . "immunization") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "Ad5E1A") (:form . "Ad5E1A") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "ad5e1a-specific") (:form . "Ad5E1A-specific")\n  (:end . 108) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 145)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ad5e1a-expressing") (:form . "Ad5E1A-expressing")\n  (:end . 166) (:start . 149) (:id . 63))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 173)\n  (:start . 167) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s382.6) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003513@unknown@formal@none@1@S@These results show that immunization with synthetic peptides can lead to the elimination of anti-tumor CTL responses.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunization") (:form . "immunization") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-tumor") (:form . "anti-tumor") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "ctl") (:form . "CTL") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x382.7.1) (:span 61 64)))\n (:hscopes ((:id . :x382.7.1) (:span 61 116)))\n (:identifiers (:sid . :s382.7) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003514@unknown@formal@none@1@S@These findings are important for the design of safe peptide-based vaccines against tumors, allogeneic organ transplants, and T-cell-mediated autoimmune diseases.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "safe") (:form . "safe") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peptide-based") (:form . "peptide-based")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "vaccine") (:form . "vaccines") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "allogeneic") (:form . "allogeneic") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "transplant") (:form . "transplants") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "t-cell-mediated") (:form . "T-cell-mediated")\n  (:end . 140) (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 160)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s382.8) (:did . :|96353908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003515@unknown@formal@none@1@S@Transgenic expression of PML/RARalpha impairs myelopoiesis.@(((:tag . "JJ") (:stem . "transgenic") (:form . "Transgenic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 45)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 58)\n  (:start . 46) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s383.1) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003516@unknown@formal@none@1@S@The translocation found in acute promyelocytic leukemia rearranges the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha (RARalpha) on chromosome 17.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "VBZ") (:stem . "rearrange") (:form . "rearranges") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 84) (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 93)\n  (:start . 85) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RARalpha") (:form . "RARalpha") (:end . 169)\n  (:start . 161) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 184)\n  (:start . 174) (:id . 70))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s383.2) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003517@unknown@formal@none@1@S@This yields a fusion transcript, PML/RARalpha, a transcription factor with reported dominant negative functions in the absence of hormone.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "yield") (:form . "yields") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s383.3) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003518@unknown@formal@none@1@S@Clinical remissions induced with all-trans retinoic acid (RA) treatment in acute promyelocytic leukemia are linked to PML/RARalpha expression in leukemic cells.@(((:tag . "JJ") (:stem . "clinical") (:form . "Clinical") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "remission") (:form . "remissions") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha")\n  (:end . 130) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s383.4) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003520@unknown@formal@none@1@S@A full-length PML/RARalpha cDNA driven by the CD11b promoter was expressed in transgenic mice.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s383.6) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003521@unknown@formal@none@1@S@Expression was confirmed in the bone marrow with a reverse transcription PCR assay.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "pcr") (:form . "PCR") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s383.7) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003522@unknown@formal@none@1@S@Basal total white blood cell and granulocyte counts did not appreciably differ between PML/RARalpha transgenic and control mice.@(((:tag . "JJ") (:stem . "basal") (:form . "Basal") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "count") (:form . "counts") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "appreciably") (:form . "appreciably") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 99)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 127)\n  (:start . 123) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x383.8.1) (:span 56 59)))\n (:nscopes ((:id . :x383.8.1) (:span 56 127)))\n (:identifiers (:sid . :s383.8) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003523@unknown@formal@none@1@S@Cell sorter analysis of CD11b+ bone marrow cells revealed similar CD11b+ populations in transgenic and control mice.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sorter") (:form . "sorter") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cd11b+") (:form . "CD11b+") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "cd11b+") (:form . "CD11b+") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 115)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s383.9) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003524@unknown@formal@none@1@S@However, in vitro clonal growth assays performed on peripheral blood from transgenic versus control mice revealed a marked reduction of myeloid progenitors, especially in those responding to granulocyte/macrophage colony-stimulating factor.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 104)\n  (:start . 100) (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 155)\n  (:start . 144) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 167)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 176)\n  (:start . 171) (:id . 68))\n ((:tag . "VBG") (:stem . "respond") (:form . "responding") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "VB") (:stem . "granulocyte/macrophage")\n  (:form . "granulocyte/macrophage") (:end . 213) (:start . 191) (:id . 71))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 232) (:start . 214) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 239)\n  (:start . 233) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s383.10) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003525@unknown@formal@none@1@S@Granulocyte/macrophage colony-stimulating factor and kit ligand cotreatment did not overcome this inhibition.@(((:tag . "JJ") (:stem . "granulocyte/macrophage")\n  (:form . "Granulocyte/macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kit") (:form . "kit") (:end . 56) (:start . 53)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 63)\n  (:start . 57) (:id . 47))\n ((:tag . "NN") (:stem . "cotreatment") (:form . "cotreatment") (:end . 75)\n  (:start . 64) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 79) (:start . 76)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 50))\n ((:tag . "VB") (:stem . "overcome") (:form . "overcome") (:end . 92)\n  (:start . 84) (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 108)\n  (:start . 98) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x383.11.1) (:span 80 83)))\n (:nscopes ((:id . :x383.11.1) (:span 80 108)))\n (:identifiers (:sid . :s383.11) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003526@unknown@formal@none@1@S@Impaired myelopoiesis in vivo was shown by stressing these mice with sublethal irradiation.@(((:tag . "JJ") (:stem . "impaired") (:form . "Impaired") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "stress") (:form . "stressing") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sublethal") (:form . "sublethal") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 90)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s383.12) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003527@unknown@formal@none@1@S@Following irradiation, PML/RARalpha transgenic mice, as compared with controls, more rapidly depressed peripheral white blood cell and granulocyte counts.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 35)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "VBD") (:stem . "depress") (:form . "depressed") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 113)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 146)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "count") (:form . "counts") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s383.13) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003528@unknown@formal@none@1@S@As expected, nearly all control mice (94.4 %) survived irradiation, yet this irradiation was lethal to 45.8 % of PML/RARalpha transgenic mice.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "94.4") (:form . "94.4") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "survive") (:form . "survived") (:end . 54)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 66)\n  (:start . 55) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 88)\n  (:start . 77) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "CD") (:stem . "45.8") (:form . "45.8") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha")\n  (:end . 125) (:start . 113) (:id . 65))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 136)\n  (:start . 126) (:id . 66))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 141)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s383.14) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003530@unknown@formal@none@1@S@Retinoic acid treatment of irradiated PML/RARalpha mice enhanced granulocyte recovery.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "irradiated") (:form . "irradiated") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 76)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 85)\n  (:start . 77) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s383.16) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003531@unknown@formal@none@1@S@These data suggest that abnormal myelopoiesis due to PML/RARalpha expression is an early event in oncogenic transformation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PML/RARalpha") (:form . "PML/RARalpha") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 122) (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x383.17.1) (:span 11 18)))\n (:hscopes ((:id . :x383.17.1) (:span 11 122)))\n (:identifiers (:sid . :s383.17) (:did . :|96353916|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003532@unknown@formal@none@1@S@Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.@(((:tag . "JJ") (:stem . "defective") (:form . "Defective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "FosB") (:form . "FosB") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s384.1) (:did . :|96355009|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003533@unknown@formal@none@1@S@Anergic CD4+ Th cells do not produce IL-2 when challenged with Ag-pulsed accessory cells because of a transcriptional defect.@(((:tag . "JJ") (:stem . "anergic") (:form . "Anergic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "challenge") (:form . "challenged") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ag-pulsed") (:form . "Ag-pulsed") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 117) (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x384.2.1) (:span 25 28)))\n (:nscopes ((:id . :x384.2.1) (:span 25 88)))\n (:identifiers (:sid . :s384.2) (:did . :|96355009|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003534@unknown@formal@none@1@S@In this work, we report that these anergic T cells are defective in their ability to up-regulate protein binding and transactivation at two critical IL-2 DNA enhancer elements: NF-AT (nuclear factor of activated T cells; a sequence that binds a heterotrimeric NFATp, Fos, and Jun protein complex) and Activator Protein-1 (AP-1) (that binds Fos and Jun heterodimers).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . 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5003535@unknown@formal@none@1@S@Western blot analysis of nuclear extracts showed that the impaired DNA-protein interactions in anergic T cells were associated with poor expression of the inducible AP-1 family members c-Fos, FosB, and JunB.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 48) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 91)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 164)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 176)\n  (:start . 170) (:id . 67))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 190)\n  (:start . 185) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "FosB") (:form . "FosB") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 206) (:start . 202)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s384.4) (:did . :|96355009|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003536@unknown@formal@none@1@S@However, the reduced expression of these proteins was not the result of a global TCR/CD3-signaling defect because CD3 cross-linking induced an equivalent increase in intracellular-free calcium ions, as well as NFATp dephosphorylation, translocation to the nucleus, and DNA binding in both normal and anergic T cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . 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"JJ") (:stem . "anergic") (:form . "anergic") (:end . 307)\n  (:start . 300) (:id . 89))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 309) (:start . 308)\n  (:id . 90))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 315)\n  (:start . 310) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 92)))@@@1@51@((:ncues ((:id . :x384.5.1) (:span 54 57)))\n (:nscopes ((:id . :x384.5.1) (:span 54 105)))\n (:identifiers (:sid . :s384.5) (:did . :|96355009|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003537@unknown@formal@none@1@S@Thus, defective IL-2 gene transcription appears to be due, at least in part, to a selective block in the expression of the AP-1 Fos and Jun family members in anergic T cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 91)\n  (:start . 82) (:id . 60))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 97) (:start . 92)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 127) (:start . 123)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 131) (:start . 128)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 139) (:start . 136)\n  (:id . 70))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 146)\n  (:start . 140) (:id . 71))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 154)\n  (:start . 147) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 165)\n  (:start . 158) (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 167) (:start . 166)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 173)\n  (:start . 168) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x384.6.1) (:span 40 47)))\n (:hscopes ((:id . :x384.6.1) (:span 6 173)))\n (:identifiers (:sid . :s384.6) (:did . :|96355009|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003538@unknown@formal@none@1@S@Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.@(((:tag . "JJ") (:stem . "elevated") (:form . "Elevated") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "amp") (:form . "AMP") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 47) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 80)\n  (:start . 71) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 102)\n  (:start . 91) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s385.1) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003540@unknown@formal@none@1@S@In this study, we examined the molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression of the tumor necrosis factor alpha (TNFalpha), tissue factor, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 genes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 40)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "elevate") (:form . "elevate") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 166)\n  (:start . 158) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 175)\n  (:start . 169) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 182)\n  (:start . 176) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 195)\n  (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 205)\n  (:start . 196) (:id . 75))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 225)\n  (:start . 215) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 239)\n  (:start . 231) (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 244) (:start . 240)\n  (:id . 81))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 253)\n  (:start . 245) (:id . 82))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 264)\n  (:start . 254) (:id . 83))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 270)\n  (:start . 265) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s385.3) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003541@unknown@formal@none@1@S@Both forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, inhibited TNFalpha and tissue factor expression at the level of transcription.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "forskolin") (:form . "forskolin") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "elevate") (:form . "elevate") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 172) (:start . 159) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s385.4) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003542@unknown@formal@none@1@S@Induction of NF-kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA).@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 32) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 75)\n  (:start . 64) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 91)\n  (:start . 82) (:id . 51))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 97) (:start . 92)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 55))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 123)\n  (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 128) (:start . 124)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 140)\n  (:start . 129) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 150) (:start . 147)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 160)\n  (:start . 151) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 172)\n  (:start . 164) (:id . 63))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 177) (:start . 173)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 184) (:start . 182)\n  (:id . 66))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 199) (:start . 185) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 216)\n  (:start . 207) (:id . 70))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 224)\n  (:start . 217) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 235)\n  (:start . 228) (:id . 73))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 242)\n  (:start . 236) (:id . 74))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 244) (:start . 243)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 246) (:start . 245)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PKA") (:form . "PKA") (:end . 249) (:start . 246)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 250) (:start . 249)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s385.5) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003543@unknown@formal@none@1@S@Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha-induced phosphorylation of p65.@(((:tag . "JJ") (:stem . "elevated") (:form . "Elevated") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 121) (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 146) (:start . 133) (:id . 62))\n ((:tag . "VB") (:stem . "modify") (:form . "modify") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . "JJ") (:stem . "tnfalpha-induced") (:form . "TNFalpha-induced")\n  (:end . 170) (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 186) (:start . 171) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 193) (:start . 190)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x385.6.1) (:span 18 21)))\n (:nscopes ((:id . :x385.6.1) (:span 18 193)))\n (:identifiers (:sid . :s385.6) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003544@unknown@formal@none@1@S@Functional studies demonstrated that transcriptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents that elevate cAMP and by overexpression of the catalytic subunit of PKA.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 31)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 52) (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 49))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 100)\n  (:start . 88) (:id . 52))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 107)\n  (:start . 101) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 113)\n  (:start . 108) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 120) (:start . 117)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 134)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 144)\n  (:start . 138) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "elevate") (:form . "elevate") (:end . 157)\n  (:start . 150) (:id . 62))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 162) (:start . 158)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 184) (:start . 170) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 201)\n  (:start . 192) (:id . 69))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 209)\n  (:start . 202) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PKA") (:form . "PKA") (:end . 216) (:start . 213)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s385.7) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003545@unknown@formal@none@1@S@This study indicates that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-kappaB-mediated transcription.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKA") (:form . "PKA") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 121)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 141)\n  (:start . 131) (:id . 64))\n ((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 160) (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 174) (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x385.8.1) (:span 11 25)))\n (:hscopes ((:id . :x385.8.1) (:span 11 174)))\n (:identifiers (:sid . :s385.8) (:did . :|96355428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003546@unknown@formal@none@1@S@Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc [published erratum appears in J Biol Chem 1996 Dec 27;271 ( 52 ):33705]@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 119)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 127)\n  (:start . 120) (:id . 64))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Biol") (:form . "Biol") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Chem") (:form . "Chem") (:end . 150) (:start . 146)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1996") (:form . "1996") (:end . 155) (:start . 151)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Dec") (:form . "Dec") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "CD") (:stem . "27;271") (:form . "27;271") (:end . 166)\n  (:start . 160) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 73))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 171) (:start . 169)\n  (:id . 74))\n ((:tag . "CD") (:stem . "):33705") (:form . "):33705") (:end . 179)\n  (:start . 172) (:id . 75))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 180) (:start . 179)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s386.1) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003547@unknown@formal@none@1@S@The cyclosporin A ( CsA ) /FK506-sensitive nuclear factor of activated T cells (NFAT) plays a key role in the inducible expression of cytokine genes in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "/fk506-sensitive") (:form . "/FK506-sensitive")\n  (:end . 42) (:start . 26) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 119)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 142)\n  (:start . 134) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s386.2) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003548@unknown@formal@none@1@S@Although NFAT has been recently shown to be inducible in several non-T immune cells, the NFAT gene family members characterized to date have been isolated only from T cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 127) (:start . 114) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s386.3) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003550@unknown@formal@none@1@S@The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFATc.beta") (:form . "NFATc.beta") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 80)\n  (:start . 74) (:id . 57))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 98)\n  (:start . 88) (:id . 60))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NFATc.alpha") (:form . "NFATc.alpha") (:end . 115)\n  (:start . 104) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s386.5) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003551@unknown@formal@none@1@S@The amino acid sequence of NFATc.beta differs from that of NFATc.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFATc.beta") (:form . "NFATc.beta") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s386.6) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003552@unknown@formal@none@1@S@alpha in the first NH2-terminal 29 residues and contains an additional region of 142 residues at the COOH terminus.@(((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "142") (:form . "142") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "COOH") (:form . "COOH") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s386.7) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003553@unknown@formal@none@1@S@Northern analysis using a probe encompassing a common region of both isoforms showed two mRNA species of 2.7 and 4.5 kilobase pairs, while an NFATc.beta-specific probe detected only the 4.5-kilobase pair mRNA which was preferentially expressed in the spleen.@(((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 84) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2.7") (:form . "2.7") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "CD") (:stem . "4.5") (:form . "4.5") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kilobase") (:form . "kilobase") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nfatc.beta-specific")\n  (:form . "NFATc.beta-specific") (:end . 161) (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "4.5-kilobase") (:form . "4.5-kilobase") (:end . 198)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 203) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 208) (:start . 204)\n  (:id . 74))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 214)\n  (:start . 209) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 218) (:start . 215)\n  (:id . 76))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 233) (:start . 219) (:id . 77))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 243)\n  (:start . 234) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 246) (:start . 244)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 80))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 257)\n  (:start . 251) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s386.8) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003554@unknown@formal@none@1@S@Transient expression of NFATc.beta was capable of activating an interleukin-2 NFAT-driven reporter gene in stimulated Jurkat cells in a CsA-sensitive manner.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFATc.beta") (:form . "NFATc.beta") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 77) (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "nfat-driven") (:form . "NFAT-driven") (:end . 89)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 124)\n  (:start . 118) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 149) (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 156)\n  (:start . 150) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s386.9) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003555@unknown@formal@none@1@S@However, NFATc.beta neither bound to the kappa3 element (an NFAT-binding site) in the tumor necrosis factor-alpha promoter nor activated the tumor necrosis factor-alpha promoter in cotransfection assays.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "NFATc.beta") (:form . "NFATc.beta") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa3") (:form . "kappa3") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nfat-binding") (:form . "NFAT-binding") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 113)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 168)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 195) (:start . 181) (:id . 70))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 202)\n  (:start . 196) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x386.10.1) (:span 20 27 123 126)))\n (:nscopes ((:id . :x386.10.1) (:span 20 202)))\n (:identifiers (:sid . :s386.10) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003556@unknown@formal@none@1@S@These data suggest that different members or isoforms of NFAT gene family may regulate inducible expression of different cytokine genes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x386.11.1) (:span 74 77))\n  ((:id . :x386.11.2) (:span 11 18)))\n (:hscopes ((:id . :x386.11.1) (:span 74 135))\n  ((:id . :x386.11.2) (:span 11 135)))\n (:identifiers (:sid . :s386.11) (:did . :|96355439|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003557@unknown@formal@none@1@S@Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "FW") (:stem . "treponema") (:form . "Treponema") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "FW") (:stem . "pallidum") (:form . "pallidum") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "FW") (:stem . "borrelia") (:form . "Borrelia") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "FW") (:stem . "burgdorferi") (:form . "burgdorferi") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "lipopeptide") (:form . "lipopeptides") (:end . 122)\n  (:start . 110) (:id . 56))\n ((:tag . "VBZ") (:stem . "proceed") (:form . "proceeds") (:end . 131)\n  (:start . 123) (:id . 57))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 135) (:start . 132)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 145)\n  (:start . 138) (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 159) (:start . 155)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 164) (:start . 160)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 186) (:start . 168) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 190) (:start . 187)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 199)\n  (:start . 191) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 219) (:start . 204) (:id . 69))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 229)\n  (:start . 220) (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 238)\n  (:start . 230) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 240) (:start . 239)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s387.1) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003558@unknown@formal@none@1@S@There is increasing evidence that lipoproteins of Treponema pallidum and Borrelia burgdorferi are key inflammatory mediators during syphilis and Lyme disease.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "FW") (:stem . "treponema") (:form . "Treponema") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "FW") (:stem . "pallidum") (:form . "pallidum") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "FW") (:stem . "borrelia") (:form . "Borrelia") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "FW") (:stem . "burgdorferi") (:form . "burgdorferi") (:end . 93)\n  (:start . 82) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 114)\n  (:start . 102) (:id . 56))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 131)\n  (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "syphilis") (:form . "syphilis") (:end . 140)\n  (:start . 132) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lyme") (:form . "Lyme") (:end . 149) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 157)\n  (:start . 150) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s387.2) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003560@unknown@formal@none@1@S@Like LPS, purified native B. burgdorferi OspA and synthetic analogs of OspA, OspB, and two T. pallidum lipoproteins (Tpp47 and Tpp17) all induced NF-kappa B translocation in THP-1 human monocytoid cells.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "FW") (:stem . "b.") (:form . "B.") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "FW") (:stem . "burgdorferi") (:form . "burgdorferi") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NNP") (:stem . "OspA") (:form . "OspA") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "OspA") (:form . "OspA") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "OspB") (:form . "OspB") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "FW") (:stem . "t.") (:form . "T.") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "FW") (:stem . "pallidum") (:form . "pallidum") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 115)\n  (:start . 103) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Tpp47") (:form . "Tpp47") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Tpp17") (:form . "Tpp17") (:end . 132)\n  (:start . 127) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 145)\n  (:start . 138) (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 154)\n  (:start . 146) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 71))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 170) (:start . 157) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 185)\n  (:start . 180) (:id . 75))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 196)\n  (:start . 186) (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s387.4) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003561@unknown@formal@none@1@S@Acylation of OspA and the synthetic peptides was requisite for cell activation.@(((:tag . "NN") (:stem . "acylation") (:form . "Acylation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "OspA") (:form . "OspA") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "requisite") (:form . "requisite") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s387.5) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003562@unknown@formal@none@1@S@Polymyxin B abrogated only the response to LPS.@(((:tag . "NNP") (:stem . "Polymyxin") (:form . "Polymyxin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s387.6) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003563@unknown@formal@none@1@S@By using 70Z/3-derived pre-B-cell lines either lacking or expressing human CD14 (the LPS receptor), it was observed that expression of human CD14 imparted responsiveness to LPS but not to OspA or spirochetal lipopeptides (assessed by induction of NF-kappa B and expression of surface immunoglobulin M).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "70z/3-derived") (:form . "70Z/3-derived")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "pre-b-cell") (:form . "pre-B-cell") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "VBG") (:stem . "lack") (:form . 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5003564@unknown@formal@none@1@S@Finally, the biological relevance of the observation that T. pallidum lipoproteins-lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells;@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "FW") (:stem . "t.") (:form . "T.") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "FW") (:stem . "pallidum") (:form . "pallidum") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "lipoproteins-lipopeptide")\n  (:form . "lipoproteins-lipopeptides") (:end . 95) (:start . 70) (:id . 53))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 102)\n  (:start . 96) (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 116)\n  (:start . 108) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 142)\n  (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 155)\n  (:start . 146) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 159) (:start . 156)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 169)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 184)\n  (:start . 177) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 201)\n  (:start . 192) (:id . 70))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 209)\n  (:start . 202) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 212) (:start . 210)\n  (:id . 72))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 220)\n  (:start . 213) (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 226)\n  (:start . 221) (:id . 74))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 243) (:start . 227) (:id . 75))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 249)\n  (:start . 244) (:id . 76))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 261)\n  (:start . 250) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 78))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 276)\n  (:start . 265) (:id . 79))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 285)\n  (:start . 277) (:id . 80))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 288) (:start . 286)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 299)\n  (:start . 289) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 305)\n  (:start . 300) (:id . 83))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 306) (:start . 305)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s387.8) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003565@unknown@formal@none@1@S@these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission.@(((:tag . "DT") (:stem . "these") (:form . "these") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "syphilitic") (:form . "syphilitic") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "chancre") (:form . "chancre") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 133) (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 152)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x387.9.1) (:span 83 86)) ((:id . :x387.9.2) (:span 24 31)))\n (:hscopes ((:id . :x387.9.1) (:span 83 152))\n  ((:id . :x387.9.2) (:span 24 152)))\n (:identifiers (:sid . :s387.9) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003566@unknown@formal@none@1@S@The combined data lend additional support to the proposal that spirochetal lipoproteins and LPS initiate monocyte activation via different cell surface events but that the signaling pathways ultimately converge to produce qualitatively similar cellular responses.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "lend") (:form . "lend") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "proposal") (:form . "proposal") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "spirochetal") (:form . "spirochetal") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 87)\n  (:start . 75) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "initiate") (:form . "initiate") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 181)\n  (:start . 172) (:id . 67))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 190)\n  (:start . 182) (:id . 68))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 201)\n  (:start . 191) (:id . 69))\n ((:tag . "VBP") (:stem . "converge") (:form . "converge") (:end . 210)\n  (:start . 202) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 213) (:start . 211)\n  (:id . 71))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 221)\n  (:start . 214) (:id . 72))\n ((:tag . "RB") (:stem . "qualitatively") (:form . "qualitatively")\n  (:end . 235) (:start . 222) (:id . 73))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 243)\n  (:start . 236) (:id . 74))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 252)\n  (:start . 244) (:id . 75))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 262)\n  (:start . 253) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x387.10.1) (:span 49 57)))\n (:hscopes ((:id . :x387.10.1) (:span 49 262)))\n (:identifiers (:sid . :s387.10) (:did . :|96355899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003567@unknown@formal@none@1@S@Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.@(((:tag . "JJ") (:stem . "chronic") (:form . "Chronic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 30) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "disrupt") (:form . "disrupts") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 98) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 106)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 127) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 148)\n  (:start . 140) (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 161) (:start . 149) (:id . 62))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 173)\n  (:start . 162) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s388.1) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003568@unknown@formal@none@1@S@Productive human immunodeficiency virus type 1 (HIV-1) infection causes sustained NF-kappaB DNA-binding activity in chronically infected monocytic cells.@(((:tag . "JJ") (:stem . "productive") (:form . "Productive") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 33) (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 39) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 127)\n  (:start . 116) (:id . 58))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 146)\n  (:start . 137) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s388.2) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003570@unknown@formal@none@1@S@To examine the molecular basis of constitutive NF-kappaB DNA-binding activity in HIV1-infected cells, we analyzed the phosphorylation and turnover of IkappaBalpha protein, the activity of the double-stranded RNA-dependent protein kinase (PKR) and the intracellular levels of NF-kappaB subunits in the PLB-985 and U937 myeloid cell models.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "constitutive") (:form . 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5003571@unknown@formal@none@1@S@HIV-1 infection resulted in constitutive, low-level expression of type 1 interferon (IFN) at the mRNA level.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "low-level") (:form . "low-level") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s388.5) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003572@unknown@formal@none@1@S@Constitutive PKR activity was also detected in HIV-1-infected cells as a result of low-level IFN production, since the addition of anti-IFN-alpha/beta antibody to the cells decreased PKR expression.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "PKR") (:form . "PKR") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 61) (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "low-level") (:form . "low-level") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "anti-ifn-alpha/beta")\n  (:form . "anti-IFN-alpha/beta") (:end . 150) (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 182)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "pkr") (:form . "PKR") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s388.6) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003573@unknown@formal@none@1@S@Furthermore, the analysis of IkappaBalpha turnover demonstrated an increased degradation of IkappaBalpha in HIV-1-infected cells that may account for the constitutive DNA binding activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 88)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 104) (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 122) (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 145)\n  (:start . 138) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 166)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 170) (:start . 167)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 178)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 187)\n  (:start . 179) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x388.7.1) (:span 134 137)))\n (:hscopes ((:id . :x388.7.1) (:span 134 187)))\n (:identifiers (:sid . :s388.7) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003574@unknown@formal@none@1@S@A dramatic increase in the intracellular levels of NF-kappaB subunits c-Rel and NF-kappaB2 p100 and a moderate increase in NF-kappaB2 p52 and RelA(p65) were detected in HIV-1-infected cells, whereas NF-kappaB1 p105/p50 levels were not altered relative to the levels in uninfected cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nf-kappab2") (:form . "NF-kappaB2") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "moderate") (:form . "moderate") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB2") (:form . "NF-kappaB2") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 183) (:start . 169) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 198)\n  (:start . 191) (:id . 71))\n ((:tag . "NN") (:stem . "nf-kappab1") (:form . "NF-kappaB1") (:end . 209)\n  (:start . 199) (:id . 72))\n ((:tag . "NN") (:stem . "p105/p50") (:form . "p105/p50") (:end . 218)\n  (:start . 210) (:id . 73))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 225)\n  (:start . 219) (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 230) (:start . 226)\n  (:id . 75))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 234) (:start . 231)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 242)\n  (:start . 235) (:id . 77))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 251)\n  (:start . 243) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 254) (:start . 252)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 258) (:start . 255)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 265)\n  (:start . 259) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 268) (:start . 266)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 279)\n  (:start . 269) (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 285)\n  (:start . 280) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x388.8.1) (:span 231 234)))\n (:nscopes ((:id . :x388.8.1) (:span 199 285)))\n (:identifiers (:sid . :s388.8) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003575@unknown@formal@none@1@S@We suggest that HIV-1 infection of myeloid cells induces IFN production and PKR activity, which in turn contribute to enhanced IkappaBalpha phosphorylation and subsequent degradation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pkr") (:form . "PKR") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 139) (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 155) (:start . 140) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 182)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x388.9.1) (:span 3 10)))\n (:hscopes ((:id . :x388.9.1) (:span 3 182)))\n (:identifiers (:sid . :s388.9) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003576@unknown@formal@none@1@S@Nuclear translocation of NF-kappaB subunits may ultimately increase the intracellular pool of NF-kappaB/IkappaBalpha by an autoregulatory mechanism.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 85) (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "pool") (:form . "pool") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB/IkappaBalpha")\n  (:form . "NF-kappaB/IkappaBalpha") (:end . 116) (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 122) (:start . 120)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 137) (:start . 123) (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 147)\n  (:start . 138) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x388.10.1) (:span 44 47)))\n (:hscopes ((:id . :x388.10.1) (:span 44 147)))\n (:identifiers (:sid . :s388.10) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003577@unknown@formal@none@1@S@Enhanced turnover of IkappaBalpha and the accumulation of NF-kappaB/Rel proteins may contribute to the chronically activated state of HIV-1-infected cells.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 148) (:start . 134) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x388.11.1) (:span 81 84)))\n (:hscopes ((:id . :x388.11.1) (:span 81 154)))\n (:identifiers (:sid . :s388.11) (:did . :|96357043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003578@unknown@formal@none@1@S@Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 40)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ebv-positive") (:form . "EBV-positive") (:end . 78)\n  (:start . 66) (:id . 50))\n ((:tag . "JJ") (:stem . "gastric") (:form . "gastric") (:end . 86)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 97) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 104)\n  (:start . 98) (:id . 54))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 110)\n  (:start . 105) (:id . 55))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 118)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s389.1) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003580@unknown@formal@none@1@S@In this study, we examined seven EBV-positive gastric carcinoma tissues for viral gene expression at the mRNA level, from which studies on the EBV oncogenicity in human epithelial cells will benefit.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ebv-positive") (:form . "EBV-positive") (:end . 45)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "gastric") (:form . "gastric") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "oncogenicity") (:form . "oncogenicity") (:end . 159)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 179)\n  (:start . 169) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . "VB") (:stem . "benefit") (:form . "benefit") (:end . 198)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s389.3) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003581@unknown@formal@none@1@S@Reverse transcription-PCR analysis showed that all seven EBV-positive tumour tissues constitutively expressed EBV nuclear antigen (EBNA) 1 mRNA, but not EBNA2 mRNA.@(((:tag . "JJ") (:stem . "reverse") (:form . "Reverse") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "transcription-PCR") (:form . "transcription-PCR")\n  (:end . 25) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 41) (:start . 35)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ebv-positive") (:form . "EBV-positive") (:end . 69)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 76)\n  (:start . 70) (:id . 50))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 99) (:start . 85) (:id . 52))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 109)\n  (:start . 100) (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 113) (:start . 110)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 121)\n  (:start . 114) (:id . 55))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 129)\n  (:start . 122) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 135) (:start . 131)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x389.4.1) (:span 149 152)))\n (:nscopes ((:id . :x389.4.1) (:span 149 163)))\n (:identifiers (:sid . :s389.4) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003582@unknown@formal@none@1@S@The EBNA transcription was initiated from one of three EBNA promoters, Qp:@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBNA") (:form . "EBNA") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Qp") (:form . "Qp") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 74) (:start . 73)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s389.5) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003583@unknown@formal@none@1@S@by contrast, both Cp and Wp were silent, thus resulting in the lack of EBNA2 mRNA.@(((:tag . "IN") (:stem . "by") (:form . "by") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Cp") (:form . "Cp") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Wp") (:form . "Wp") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "silent") (:form . "silent") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 45) (:start . 41)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 55)\n  (:start . 46) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 67) (:start . 63)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EBNA2") (:form . "EBNA2") (:end . 76) (:start . 71)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 81) (:start . 77)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x389.6.1) (:span 63 67)))\n (:nscopes ((:id . :x389.6.1) (:span 63 81)))\n (:identifiers (:sid . :s389.6) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003584@unknown@formal@none@1@S@Latent membrane protein (LMP) 2A mRNA was detected in three of seven cases;@(((:tag . "JJ") (:stem . "latent") (:form . "Latent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 75) (:start . 74)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s389.7) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003585@unknown@formal@none@1@S@however, neither LMP1 nor LMP2B mRNA was detected in any of the tumours tested.@(((:tag . "RB") (:stem . "however") (:form . "however") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LMP2B") (:form . "LMP2B") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "tumour") (:form . "tumours") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 78) (:start . 72)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x389.8.1) (:span 9 16 22 25)))\n (:nscopes ((:id . :x389.8.1) (:span 9 78)))\n (:identifiers (:sid . :s389.8) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003586@unknown@formal@none@1@S@Transcripts from the BamHI-A region of the viral genome were detectable in all cases.@(((:tag . "NNS") (:stem . "transcript") (:form . "Transcripts") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BamHI-A") (:form . "BamHI-A") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s389.9) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003587@unknown@formal@none@1@S@BZLF1 mRNA and the product, an immediate-early gene for EBV replication, was not expressed in any of them, thereby suggesting that the tumour cells carried EBV genomes in a tightly latent form.@(((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 46) (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 125)\n  (:start . 115) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 141)\n  (:start . 135) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 68))\n ((:tag . "VBD") (:stem . "carry") (:form . "carried") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 167)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 73))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 180)\n  (:start . 173) (:id . 74))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 187)\n  (:start . 181) (:id . 75))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x389.10.1) (:span 115 125)))\n (:ncues ((:id . :x389.10.2) (:span 77 80)))\n (:hscopes ((:id . :x389.10.1) (:span 115 192)))\n (:nscopes ((:id . :x389.10.2) (:span 0 105)))\n (:identifiers (:sid . :s389.10) (:did . :|96358388|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003588@unknown@formal@none@1@S@These findings further extended our previous data regarding EBV latency in gastric carcinoma cells at the protein level, and have affirmed that the programme of viral gene expression in the tumour more closely resembles 'latency I' represented by Burkitt's lymphoma than 'latency II' represented by the majority of nasopharyngeal carcinomas.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "extend") (:form . "extended") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . 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5003590@unknown@formal@none@1@S@B-cell-specific transcription of immunoglobulin genes is mediated by the interaction of a POU domain containing transcription factor Oct-1 or Oct-2, with the B-cell-specific coactivator OCA-B (Bob-1, OBF-1) and a prototype octamer element.@(((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 47) (:start . 33) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 53) (:start . 48)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 84)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 125) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 132)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 138)\n  (:start . 133) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 173) (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 185)\n  (:start . 174) (:id . 66))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 191)\n  (:start . 186) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Bob-1") (:form . "Bob-1") (:end . 198)\n  (:start . 193) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "OBF-1") (:form . "OBF-1") (:end . 205)\n  (:start . 200) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 212) (:start . 211)\n  (:id . 74))\n ((:tag . "NN") (:stem . "prototype") (:form . "prototype") (:end . 222)\n  (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 230)\n  (:start . 223) (:id . 76))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 238)\n  (:start . 231) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s390.2) (:did . :|96365473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003591@unknown@formal@none@1@S@We find that OCA-B binds DNA directly in the major groove between the two subdomains of the POU domain, requiring both an A at the fifth position of the octamer element and contact with the POU domain.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "groove") (:form . "groove") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "subdomain") (:form . "subdomains") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 113)\n  (:start . 104) (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 126) (:start . 124)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "fifth") (:form . "fifth") (:end . 136)\n  (:start . 131) (:id . 68))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 145)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 71))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 160)\n  (:start . 153) (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 168)\n  (:start . 161) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 74))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 180)\n  (:start . 173) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 193) (:start . 190)\n  (:id . 78))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 200)\n  (:start . 194) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s390.3) (:did . :|96365473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003592@unknown@formal@none@1@S@An amino-terminal fragment of OCA-B binds the octamer site in the absence of a POU domain with the same sequence specificity.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 124)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s390.4) (:did . :|96365473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003593@unknown@formal@none@1@S@Coactivator OCA-B may undergo a POU-dependent conformational change that exposes its amino terminus, allowing it to recognize specific DNA sequences in the major groove within the binding site for Oct-1 or Oct-2.@(((:tag . "NNP") (:stem . "Coactivator") (:form . "Coactivator") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pou-dependent") (:form . "POU-dependent")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "conformational") (:form . "conformational")\n  (:end . 60) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 67)\n  (:start . 61) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "expose") (:form . "exposes") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "VB") (:stem . "recognize") (:form . "recognize") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "groove") (:form . "groove") (:end . 168)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 175)\n  (:start . 169) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 202)\n  (:start . 197) (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 211)\n  (:start . 206) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x390.5.1) (:span 18 21)))\n (:hscopes ((:id . :x390.5.1) (:span 18 211)))\n (:identifiers (:sid . :s390.5) (:did . :|96365473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003594@unknown@formal@none@1@S@The recognition of both the POU domain and the octamer sequence by OCA-B provides a mechanism for differential regulation of octamer sites containing genes by the ubiquitous factor Oct-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 110)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 173)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 180)\n  (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s390.6) (:did . :|96365473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003595@unknown@formal@none@1@S@The role of early growth response gene 1 (egr-1) in regulation of the immune response.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 62)\n  (:start . 52) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 76)\n  (:start . 70) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 85)\n  (:start . 77) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s391.1) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003596@unknown@formal@none@1@S@The induction of immediate early genes in cells of the immune system is critical to determining the ultimate outcome of exposure to antigen.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ultimate") (:form . "ultimate") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "outcome") (:form . "outcome") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s391.2) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003597@unknown@formal@none@1@S@The importance of many of these genes relates to the role their transcription factor products play in dictating patterns of expression of downstream, function-related genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "relate") (:form . "relates") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 63)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "dictate") (:form . "dictating") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "function-related") (:form . "function-related")\n  (:end . 166) (:start . 150) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s391.3) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003598@unknown@formal@none@1@S@Evidence from several systems indicates that the immediate early gene, egr-1 may be of particular importance in the immune system.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x391.4.1) (:span 77 80)) ((:id . :x391.4.2) (:span 30 44)))\n (:hscopes ((:id . :x391.4.1) (:span 77 129))\n  ((:id . :x391.4.2) (:span 30 129)))\n (:identifiers (:sid . :s391.4) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003600@unknown@formal@none@1@S@Furthermore, an important role for egr-1 in determining the differentiation pathway of myeloid cell precursors has been recently elaborated.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 75) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "VBN") (:stem . "elaborate") (:form . "elaborated") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s391.6) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003601@unknown@formal@none@1@S@Finally, potential targets of regulation by the zinc-finger transcription factor encoded by egr-1 include the interleukin-2, CD44, ICAM-1, and tumor necrosis factor genes.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD44") (:form . "CD44") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s391.7) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003602@unknown@formal@none@1@S@The role of egr-1 in regulation of the immune response will be discussed in the context of these recent studies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s391.8) (:did . :|96369636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003603@unknown@formal@none@1@S@Translocation (3;14)(q27;q11): a new variant translocation in a patient with non-Hodgkin 's lymphoma of B-cell type with BCL6 rearrangement.@(((:tag . "NNP") (:stem . "Translocation") (:form . "Translocation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "3;14)(q27;q11)") (:form . "3;14)(q27;q11)")\n  (:end . 29) (:start . 15) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 58) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ|NN") (:stem . "non-hodgkin") (:form . "non-Hodgkin") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s392.1) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003604@unknown@formal@none@1@S@We report a 65-year-old woman with non-Hodgkin 's lymphoma (NHL) carrying a t(3;14)(q27;q11) and BCL6 rearrangement in the affected cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "65-year-old") (:form . "65-year-old") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "woman") (:form . "woman") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ|NN") (:stem . "non-hodgkin") (:form . "non-Hodgkin") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NHL") (:form . "NHL") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t(3;14)(q27;q11)") (:form . "t(3;14)(q27;q11)")\n  (:end . 92) (:start . 76) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bcl6") (:form . "BCL6") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s392.2) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003605@unknown@formal@none@1@S@She had generalized lymphadenopathy and the bone marrow was infiltrated by lymphoma cells at presentation.@(((:tag . "PRP") (:stem . "she") (:form . "She") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "generalize") (:form . "generalized") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "lymphadenopathy") (:form . "lymphadenopathy")\n  (:end . 35) (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "infiltrate") (:form . "infiltrated") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s392.3) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003606@unknown@formal@none@1@S@Histological diagnosis was "malignant lymphoma, diffuse, large cell" type according to an International Working Formulation.@(((:tag . "JJ") (:stem . "histological") (:form . "Histological") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "diagnosis") (:form . "diagnosis") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "\\"malignant") (:form . "\\"malignant") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "diffuse") (:form . "diffuse") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "International") (:form . "International")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "Working") (:form . "Working") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "Formulation") (:form . "Formulation") (:end . 123)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s392.4) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003607@unknown@formal@none@1@S@Chromosome analysis revealed a t(3;14)(q27;q11), which is a new variant translocation of t(3;14)(q27;q32).@(((:tag . "NN") (:stem . "chromosome") (:form . "Chromosome") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t(3;14)(q27;q11)") (:form . "t(3;14)(q27;q11)")\n  (:end . 47) (:start . 31) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "t(3;14)(q27;q32)") (:form . "t(3;14)(q27;q32)")\n  (:end . 105) (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s392.5) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003608@unknown@formal@none@1@S@Southern blot analysis showed rearrangement of BCL6, JH, and TCR beta but not of TCR delta.@(((:tag . "NNP") (:stem . "Southern") (:form . "Southern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BCL6") (:form . "BCL6") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "JH") (:form . "JH") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x392.6.1) (:span 74 77)))\n (:nscopes ((:id . :x392.6.1) (:span 74 90)))\n (:identifiers (:sid . :s392.6) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003610@unknown@formal@none@1@S@Although the band 14q11 is a locus of T-cell receptor alpha- and delta-chains (TCR alpha/delta), lymphoma cells expressed B-cell, IgGk phenotype.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "14q11") (:form . "14q11") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "alpha-") (:form . "alpha-") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "delta-chain") (:form . "delta-chains") (:end . 77)\n  (:start . 65) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha/delta") (:form . "alpha/delta") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cell") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IgGk") (:form . "IgGk") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 144)\n  (:start . 135) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s392.8) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003611@unknown@formal@none@1@S@The findings suggest that a novel proto-oncogene in the vicinity of TCR alpha/delta is involved in this translocation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 48) (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vicinity") (:form . "vicinity") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha/delta") (:form . "alpha/delta") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 117) (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x392.9.1) (:span 13 20)))\n (:hscopes ((:id . :x392.9.1) (:span 13 117)))\n (:identifiers (:sid . :s392.9) (:did . :|96374456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003612@unknown@formal@none@1@S@Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.@(((:tag . "NNP") (:stem . "Cross") (:form . "Cross") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "talk") (:form . "talk") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "nfat-mediated") (:form . "NFAT-mediated")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s393.1) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003613@unknown@formal@none@1@S@BCL-2-deficient T cells demonstrate accelerated cell cycle progression and increased apoptosis following activation.@(((:tag . "JJ") (:stem . "bcl-2-deficient") (:form . "BCL-2-deficient")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "VBN") (:stem . "accelerate") (:form . "accelerated") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 70)\n  (:start . 59) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 104)\n  (:start . 95) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s393.2) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003614@unknown@formal@none@1@S@Increasing the levels of BCL-2 retarded the G0 --> S transition, sustained the levels of cyclin-dependent kinase inhibitor p27Kip1, and repressed postactivation death.@(((:tag . "VBG") (:stem . "increase") (:form . "Increasing") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "retard") (:form . "retarded") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "G0") (:form . "G0") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "SYM") (:stem . ">") (:form . "–>") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "sustain") (:form . "sustained") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 105) (:start . 89) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "repress") (:form . "repressed") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "postactivation") (:form . "postactivation")\n  (:end . 160) (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 166)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s393.3) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003615@unknown@formal@none@1@S@Proximal signal transduction events and immediate early gene transcription were unaffected.@(((:tag . "JJ") (:stem . "proximal") (:form . "Proximal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s393.4) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003616@unknown@formal@none@1@S@However, the transcription and synthesis of interleukin 2 and other delayed early cytokines were markedly attenuated by BCL-2.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s393.5) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003617@unknown@formal@none@1@S@In contrast, a cysteine protease inhibitor that also blocks apoptosis had no substantial affect upon cytokine production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "affect") (:form . "affect") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x393.6.1) (:span 74 76)))\n (:nscopes ((:id . :x393.6.1) (:span 74 120)))\n (:identifiers (:sid . :s393.6) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003618@unknown@formal@none@1@S@InterleUkin 2 expression requires several transcription factors of which nuclear translocation of NFAT (nuclear factor of activated T cells) and NFAT-mediated transactivation were impaired by BCL-2.@(((:tag . "NNP") (:stem . "InterleUkin") (:form . "InterleUkin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 94) (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 102) (:start . 98)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 118)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nfat-mediated") (:form . "NFAT-mediated")\n  (:end . 158) (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 174) (:start . 159) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "impair") (:form . "impaired") (:end . 188)\n  (:start . 180) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 191) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 197)\n  (:start . 192) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s393.7) (:did . :|96382503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003620@unknown@formal@none@1@S@Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "5b") (:form . "5b") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ErbB") (:form . "ErbB") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s394.1) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003621@unknown@formal@none@1@S@Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation.@(((:tag . "NN") (:stem . "self") (:form . "Self") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "renewal") (:form . "renewal") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "NNP") (:stem . "c-ErbB") (:form . "c-ErbB") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "c-Kit/Epo-R") (:form . "c-Kit/Epo-R") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 168) (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s394.2) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003622@unknown@formal@none@1@S@To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "c-ErbB") (:form . "c-ErbB") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 153)\n  (:start . 144) (:id . 65))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 173) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 187) (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 194)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 201)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x394.3.1) (:span 36 41)) ((:id . :x394.3.2) (:span 11 19)))\n (:hscopes ((:id . :x394.3.1) (:span 36 83))\n  ((:id . :x394.3.2) (:span 11 83)))\n (:identifiers (:sid . :s394.3) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003623@unknown@formal@none@1@S@Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts.@(((:tag . "NNP") (:stem . "Ligand") (:form . "Ligand") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "c-ErbB") (:form . "c-ErbB") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 64) (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "5b") (:form . "5b") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 138) (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s394.4) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003624@unknown@formal@none@1@S@In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-kit") (:form . "c-Kit") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x394.5.1) (:span 44 50)))\n (:nscopes ((:id . :x394.5.1) (:span 44 99)))\n (:identifiers (:sid . :s394.5) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003625@unknown@formal@none@1@S@Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 69)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "5b") (:form . "5b") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 92) (:start . 86)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x394.6.1) (:span 86 92)))\n (:nscopes ((:id . :x394.6.1) (:span 86 130)))\n (:identifiers (:sid . :s394.6) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003626@unknown@formal@none@1@S@These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "RB") (:stem . "perfectly") (:form . "perfectly") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-erbb") (:form . "c-ErbB") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "self") (:form . "self") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "renewal") (:form . "renewal") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 140)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s394.7) (:did . :|96382512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003627@unknown@formal@none@1@S@Calcineurin mutants render T lymphocytes resistant to cyclosporin A.@(((:tag . "NNP") (:stem . "Calcineurin") (:form . "Calcineurin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "render") (:form . "render") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 65)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s395.1) (:did . :|96387353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003628@unknown@formal@none@1@S@The immunosuppressants cyclosporin A (CsA) and FK506 have been widely used to prevent and treat graft rejection after human organ and tissue transplantations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 34)\n  (:start . 23) (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 36) (:start . 35)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "VB") (:stem . "treat") (:form . "treat") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "graft") (:form . "graft") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "NNS") (:stem . "transplantation") (:form . "transplantations")\n  (:end . 157) (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s395.2) (:did . :|96387353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003630@unknown@formal@none@1@S@The common target of CsA and FK506 is calcineurin, a Ca2+/calmodulin-regulated, serine/threonine-specific protein phosphatase that regulates the nuclear import of a transcription factor, NF-AT, required for expression of T cell activation genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-regulated")\n  (:form . "Ca2+/calmodulin-regulated") (:end . 78) (:start . 53) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "serine/threonine-specific")\n  (:form . "serine/threonine-specific") (:end . 105) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 125)\n  (:start . 114) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 140)\n  (:start . 131) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 152)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 159)\n  (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 178) (:start . 165) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 185)\n  (:start . 179) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 192)\n  (:start . 187) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 202)\n  (:start . 194) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 206) (:start . 203)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 217)\n  (:start . 207) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 222) (:start . 221)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 227) (:start . 223)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 238)\n  (:start . 228) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 244)\n  (:start . 239) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s395.4) (:did . :|96387353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003631@unknown@formal@none@1@S@In previous studies, we identified calcineurin mutations that block binding by the cyclophilin A/CsA or FKBP12/FK506 complexes and thereby render yeast cells resistant to the antifungal effects of CsA or FK506.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "NNP") (:stem . "A/CsA") (:form . "A/CsA") (:end . 100)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FKBP12/FK506") (:form . "FKBP12/FK506")\n  (:end . 116) (:start . 104) (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "VBP") (:stem . "render") (:form . "render") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 167)\n  (:start . 158) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "antifungal") (:form . "antifungal") (:end . 185)\n  (:start . 175) (:id . 68))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 193)\n  (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 209)\n  (:start . 204) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s395.5) (:did . :|96387353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003632@unknown@formal@none@1@S@In this report, we demonstrate that the corresponding mutations in murine calcineurin render the T cell receptor signal transduction cascade CsA resistant in human Jurkat T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 53)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . "VBP") (:stem . "render") (:form . "render") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 132)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 154)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s395.6) (:did . :|96387353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003633@unknown@formal@none@1@S@Our findings support the recently determined calcineurin X-ray crystal structure, provide evidence that calcineurin is the only CsA-sensitive component limiting signaling from the T cell receptor to the nucleus, and suggest a means to render cells and tissues resistant to the toxic side effects of CsA and FK506.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "calcineurin") (:form . 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5003634@unknown@formal@none@1@S@Retinoid differentiation therapy in promyelocytic leukemia.@(((:tag . "NN") (:stem . "retinoid") (:form . "Retinoid") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 49) (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 58)\n  (:start . 50) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s396.1) (:did . :|96388957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003635@unknown@formal@none@1@S@Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia characterized by the morphology of the blast cells, a specific t(15;17) translocation, and risks of definite coagulopathy.@(((:tag . "JJ") (:stem . "acute") (:form . "Acute") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "JJ") (:stem . "t(15;17)") (:form . "t(15;17)") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 165) (:start . 152) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "risk") (:form . "risks") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "definite") (:form . "definite") (:end . 188)\n  (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "coagulopathy") (:form . "coagulopathy") (:end . 201)\n  (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s396.2) (:did . :|96388957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003636@unknown@formal@none@1@S@Recently this leukemia was further characterized by an exquisite sensitivity to all-trans retinoic acid 's differentiation effect and the production of a fusion gene altering the gene of RARalpha and a novel gene PML.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "exquisite") (:form . "exquisite") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 122) (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 129)\n  (:start . 123) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 148)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 160)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 183) (:start . 179)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "RARalpha") (:form . "RARalpha") (:end . 195)\n  (:start . 187) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 201) (:start . 200)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 207)\n  (:start . 202) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 212) (:start . 208)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 216) (:start . 213)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s396.3) (:did . :|96388957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003637@unknown@formal@none@1@S@In vivo differentiation therapy with retinoids in APL patients follows strict guidelines related both to the APL cell and the biodisposal of all-trans retinoic acid.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 23) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "JJ") (:stem . "strict") (:form . "strict") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "guideline") (:form . "guidelines") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "biodisposal") (:form . "biodisposal") (:end . 137)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s396.4) (:did . :|96388957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003638@unknown@formal@none@1@S@Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "disrupt") (:form . "disrupted") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "brlf1") (:form . "BRLF1") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 100) (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s397.1) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003640@unknown@formal@none@1@S@Understanding how viral latency is disrupted is a central issue in herpesvirus biology.@(((:tag . "VBG") (:stem . "understand") (:form . "Understanding") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "disrupt") (:form . "disrupted") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "biology") (:form . "biology") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s397.3) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003641@unknown@formal@none@1@S@Epithelial cells are the major site of lytic EBV replication within the human host, and viral reactivation occurs in EBV-associated nasopharyngeal carcinomas.@(((:tag . "JJ") (:stem . "epithelial") (:form . "Epithelial") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 106)\n  (:start . 94) (:id . 59))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ebv-associated") (:form . "EBV-associated")\n  (:end . 131) (:start . 117) (:id . 62))\n ((:tag . "JJ") (:stem . "nasopharyngeal") (:form . "nasopharyngeal")\n  (:end . 146) (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "carcinoma") (:form . "carcinomas") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s397.4) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003642@unknown@formal@none@1@S@It is known that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiate the switch from latent to lytic infection in B cells.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 61) (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 145)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s397.5) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003643@unknown@formal@none@1@S@Cellular regulation of BZLF1 transcription is therefore thought to play a key role in regulating the stringency of viral latency.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stringency") (:form . "stringency") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x397.6.1) (:span 56 63)))\n (:hscopes ((:id . :x397.6.1) (:span 0 128)))\n (:identifiers (:sid . :s397.6) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003644@unknown@formal@none@1@S@Here we show that , unexpectedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latency in an epithelial cell-specific fashion.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "unexpectedly") (:form . "unexpectedly") (:end . 32)\n  (:start . 20) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 77) (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BRLF1") (:form . "BRLF1") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 136)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 150) (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s397.7) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003645@unknown@formal@none@1@S@Therefore, the mechanisms leading to disruption of EBV latency appear to be cell-type specific.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x397.8.1) (:span 63 69)))\n (:hscopes ((:id . :x397.8.1) (:span 11 94)))\n (:identifiers (:sid . :s397.8) (:did . :|96392389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003646@unknown@formal@none@1@S@IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.@(((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il13") (:form . "IL13") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s398.1) (:did . :|96397528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003647@unknown@formal@none@1@S@IL13 induces the same biological effects as IL4 in normal human B cells.@(((:tag . "NNP") (:stem . "IL13") (:form . "IL13") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s398.2) (:did . :|96397528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003648@unknown@formal@none@1@S@We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL4R") (:form . "IL4R") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 35)\n  (:start . 28) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 41) (:start . 37)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL4R") (:form . "IL4R") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 52) (:start . 47)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il2r") (:form . "IL2R") (:end . 61) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 67) (:start . 62)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 69) (:start . 68)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 84)\n  (:start . 74) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL13R") (:form . "IL13R") (:end . 97) (:start . 92)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 111) (:start . 107)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 121)\n  (:start . 112) (:id . 66))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 129)\n  (:start . 122) (:id . 67))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 142)\n  (:start . 137) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 152)\n  (:start . 147) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 163)\n  (:start . 153) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s398.3) (:did . :|96397528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003650@unknown@formal@none@1@S@IL13 is unable to activate JAK1 and JAK3.@(((:tag . "NNP") (:stem . "IL13") (:form . "IL13") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NNP") (:stem . "JAK1") (:form . "JAK1") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 41) (:start . 40)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x398.5.1) (:span 8 14)))\n (:nscopes ((:id . :x398.5.1) (:span 8 40)))\n (:identifiers (:sid . :s398.5) (:did . :|96397528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003651@unknown@formal@none@1@S@Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism.@(((:tag . "VBN") (:stem . "attenuate") (:form . "Attenuated") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 61) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Id-3") (:form . "Id-3") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 104)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s399.1) (:did . :|96397543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003652@unknown@formal@none@1@S@The Id family of helix-loop-helix proteins function as negative regulators of DNA binding, basic helix-loop-helix proteins in the regulation of cell growth and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "id") (:form . "Id") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 33) (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 113) (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 175) (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s399.2) (:did . :|96397543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003653@unknown@formal@none@1@S@We report here on the identification of a 17 kDa variant of the 14 kDa Id-3 protein termed Id-3L (long version) which possesses a unique 60 amino acid carboxy-terminus generated by read through of a ' coding intron ' and alternative splicing.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "id-3") (:form . "Id-3") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 58))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 90) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Id-3L") (:form . "Id-3L") (:end . 96) (:start . 91)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 102) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 110)\n  (:start . 103) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 117)\n  (:start . 112) (:id . 65))\n ((:tag . "VBZ") (:stem . "possess") (:form . "possesses") (:end . 127)\n  (:start . 118) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 136)\n  (:start . 130) (:id . 68))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 139) (:start . 137)\n  (:id . 69))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 145)\n  (:start . 140) (:id . 70))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 150) (:start . 146)\n  (:id . 71))\n ((:tag . "NN") (:stem . "carboxy-terminus") (:form . "carboxy-terminus")\n  (:end . 167) (:start . 151) (:id . 72))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 177)\n  (:start . 168) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "read") (:form . "read") (:end . 185) (:start . 181)\n  (:id . 75))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 193)\n  (:start . 186) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 198) (:start . 197)\n  (:id . 78))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 200) (:start . 199)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 207)\n  (:start . 201) (:id . 80))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 214)\n  (:start . 208) (:id . 81))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 216) (:start . 215)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 232)\n  (:start . 221) (:id . 84))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 241)\n  (:start . 233) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s399.3) (:did . :|96397543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003654@unknown@formal@none@1@S@Northern analysis revealed expression of a minor 1.1 kb Id-3L transcript together with the predominant 0.95 kb Id-3 transcript in the majority of adult human tissues analysed.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1.1") (:form . "1.1") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Id-3L") (:form . "Id-3L") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "CD") (:stem . "0.95") (:form . "0.95") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "id-3") (:form . "Id-3") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 165)\n  (:start . 158) (:id . 67))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s399.4) (:did . :|96397543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003655@unknown@formal@none@1@S@The variant Id-3L protein is functionally distinguishable from conventional Id-3 since in in vitro DNA mobility shift assays, it was greatly impaired in its ability to abrogate binding of the basic helix-loop-helix protein, E47, to an E box recognition sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Id-3L") (:form . "Id-3L") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "distinguishable") (:form . "distinguishable")\n  (:end . 57) (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "conventional") (:form . "conventional") (:end . 75)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "id-3") (:form . "Id-3") (:end . 80) (:start . 76)\n  (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "VB") (:stem . "abrogate") (:form . "abrogate") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 214) (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 222)\n  (:start . 215) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 227) (:start . 224)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 231) (:start . 229)\n  (:id . 79))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 236) (:start . 235)\n  (:id . 81))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 240) (:start . 237)\n  (:id . 82))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 252)\n  (:start . 241) (:id . 83))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 261)\n  (:start . 253) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s399.5) (:did . :|96397543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003656@unknown@formal@none@1@S@Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.@(((:tag . "NNP") (:stem . "Multifactor") (:form . "Multifactor") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cis-dominant") (:form . "cis-dominant") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 33)\n  (:start . 25) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 44)\n  (:start . 34) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "anergize") (:form . "anergized") (:end . 81)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s400.1) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003657@unknown@formal@none@1@S@The molecular mechanism underlying IL-2 transcriptional blockade in anergic T cell clones is not fully understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 55) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 75)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 113)\n  (:start . 103) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x400.2.1) (:span 93 96)))\n (:nscopes ((:id . :x400.2.1) (:span 0 113)))\n (:identifiers (:sid . :s400.2) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003658@unknown@formal@none@1@S@To examine whether an active negative regulatory process occurs, we created a reporter construct containing as an enhancer four copies of the NF-AT site and one copy of the octamer site (4X NF-AT-Oct).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "create") (:form . "created") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "copy") (:form . "copy") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 180)\n  (:start . 173) (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 185) (:start . 181)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "4x") (:form . "4X") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-AT-Oct") (:form . "NF-AT-Oct") (:end . 199)\n  (:start . 190) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x400.3.1) (:span 11 18)))\n (:hscopes ((:id . :x400.3.1) (:span 11 63)))\n (:identifiers (:sid . :s400.3) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003660@unknown@formal@none@1@S@Addition of the -176 to -96 sequence to the 4X NF-AT-Oct construct did not impart the ability to be affected by anergy, but addition of the -236 to -96 sequence did, demonstrating that anergy is an active inhibitory process and that more than the presence of the -150 AP-1 binding site (-152 to -147) is required to mediate the effect.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "-176") (:form . "-176") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-96") (:form . "-96") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . 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5003661@unknown@formal@none@1@S@Mutational studies of the -236 to -96 sequence indicated that the presence of both the -130 AP-1-like site (-187 to -181) and the -150 proximal AP-1 site were necessary to observe anergy.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-236") (:form . "-236") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-96") (:form . "-96") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-130") (:form . "-130") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ap-1-like") (:form . "AP-1-like") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-187") (:form . "-187") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "CD") (:stem . "-181") (:form . "-181") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-150") (:form . "-150") (:end . 134) (:start . 130)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 143)\n  (:start . 135) (:id . 68))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 148) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 153) (:start . 149)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 158) (:start . 154)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 168)\n  (:start . 159) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "VB") (:stem . "observe") (:form . "observe") (:end . 179)\n  (:start . 172) (:id . 74))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 186)\n  (:start . 180) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x400.6.1) (:span 47 61)))\n (:hscopes ((:id . :x400.6.1) (:span 47 186)))\n (:identifiers (:sid . :s400.6) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003662@unknown@formal@none@1@S@Because the -180 site is not required for trans-activation, it was possible to confirm by mutation in the normal mouse IL-2 enhancer that this site is absolutely essential for anergy induction.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "CD") (:stem . "-180") (:form . "-180") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 58) (:start . 42) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "RB") (:stem . "absolutely") (:form . "absolutely") (:end . 161)\n  (:start . 151) (:id . 69))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 171)\n  (:start . 162) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 182)\n  (:start . 176) (:id . 72))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 192)\n  (:start . 183) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x400.7.1) (:span 67 75)))\n (:ncues ((:id . :x400.7.2) (:span 25 28)))\n (:hscopes ((:id . :x400.7.1) (:span 67 192)))\n (:nscopes ((:id . :x400.7.2) (:span 8 58)))\n (:identifiers (:sid . :s400.7) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003663@unknown@formal@none@1@S@The simplest model to explain these results is that anergy is mediated by a complex of multiple transcription factors that exert a cis-acting dominant negative regulatory effect on the trans-activation of the IL-2 gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "simple") (:form . "simplest") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 141)\n  (:start . 131) (:id . 64))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 170)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 201) (:start . 185) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 213) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 218) (:start . 214)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s400.8) (:did . :|96399059|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003664@unknown@formal@none@1@S@Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 66) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s401.1) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003665@unknown@formal@none@1@S@MNDA (myeloid cell nuclear differentiation antigen) is an interferon alpha regulated nuclear protein expressed only in cells of the human myelomonocytic lineage.@(((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 42) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "regulate") (:form . "regulated") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 152) (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s401.2) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003666@unknown@formal@none@1@S@To identify mechanisms responsible for this lineage-specific and interferon-regulated expression, the 5' flanking sequence of the gene has been characterized.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 60) (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "interferon-regulated")\n  (:form . "interferon-regulated") (:end . 85) (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 53))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 103) (:start . 102)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 122)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 157) (:start . 144) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s401.3) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003667@unknown@formal@none@1@S@Two interferon-stimulated response elements (ISRE) flank a multiple transcription start site region identifying MNDA as a TATA-less interferon-regulated gene.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "interferon-stimulated")\n  (:form . "interferon-stimulated") (:end . 25) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 43)\n  (:start . 35) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "isre") (:form . "ISRE") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "flank") (:form . "flank") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 111)\n  (:start . 100) (:id . 56))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "tata-less") (:form . "TATA-less") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "interferon-regulated")\n  (:form . "interferon-regulated") (:end . 152) (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s401.4) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003668@unknown@formal@none@1@S@Other DNA elements present include a cluster of Myb sites, several Ets, an Ets related PU.1 site and an Sp1 site located within 600 bp of the transcription start sites.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Myb") (:form . "Myb") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "et") (:form . "Ets") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 120)\n  (:start . 113) (:id . 65))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 127)\n  (:start . 121) (:id . 66))\n ((:tag . "CD") (:stem . "600") (:form . "600") (:end . 131) (:start . 128)\n  (:id . 67))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 134) (:start . 132)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 155) (:start . 142) (:id . 71))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 161)\n  (:start . 156) (:id . 72))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 167)\n  (:start . 162) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s401.5) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003670@unknown@formal@none@1@S@The 5' flanking sequence has promoter activity which is elevated by interferon alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 15)\n  (:start . 7) (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s401.7) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003671@unknown@formal@none@1@S@The findings indicate that MNDA expression is regulated by mechanisms similar to other myelomonocytic cell specific genes and genes up-regulated by interferon alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 101) (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 144)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 158)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 164)\n  (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x401.8.1) (:span 13 26)))\n (:hscopes ((:id . :x401.8.1) (:span 13 164)))\n (:identifiers (:sid . :s401.8) (:did . :|96404971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003672@unknown@formal@none@1@S@Regulation of GM-CSF gene transcription by core-binding factor.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "core-binding") (:form . "core-binding") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s402.1) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003673@unknown@formal@none@1@S@GM-CSF gene activation in T cells is known to involve the transcription factors nuclear factor-kappa B, AP-1, NFAT, and Sp1.@(((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 100)\n  (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s402.2) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003674@unknown@formal@none@1@S@Here we demonstrate that the human GM-CSF promoter and enhancer also encompass binding sites for core-binding factor (CBF).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "encompass") (:form . "encompass") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "core-binding") (:form . "core-binding") (:end . 109)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s402.3) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003675@unknown@formal@none@1@S@Significantly, the CBF sites are in each case contained within the minimum essential core regions required for inducible activation of transcription.@(((:tag . "RB") (:stem . "significantly") (:form . "Significantly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 148) (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s402.4) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003676@unknown@formal@none@1@S@Furthermore, these core regions of the enhancer and promoter each encompass closely linked binding sites for CBF, AP-1, and NFATp.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "encompass") (:form . "encompass") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 90) (:start . 84)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s402.5) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003677@unknown@formal@none@1@S@The GM-CSF promoter CBF site TGTGGTCA is located 51 bp upstream of the transcription start site and also overlaps a YY-1 binding site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TGTGGTCA") (:form . "TGTGGTCA") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "CD") (:stem . "51") (:form . "51") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "yy-1") (:form . "YY-1") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s402.6) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003678@unknown@formal@none@1@S@A 2-bp mutation within the CBF site resulted in a 2-3-fold decrease in the activities of both a 69-bp proximal promoter fragment and a 627-bp full-length promoter fragment.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "2-bp") (:form . "2-bp") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "2-3-fold") (:form . "2-3-fold") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "69-bp") (:form . "69-bp") (:end . 101) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "627-bp") (:form . "627-bp") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 153)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 162)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s402.7) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003680@unknown@formal@none@1@S@The AML1 and CBF beta genes that encode CBF each have the ability to influence cell growth and differentiation and have been implicated as proto-oncogenes in acute myeloid leukemia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 110) (:start . 95) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 154) (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 180)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s402.9) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003681@unknown@formal@none@1@S@This study adds GM-CSF to a growing list of cytokines and receptors that are regulated by CBF and which control the growth, differentiation, and activation of hemopoietic cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "add") (:form . "adds") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CBF") (:form . "CBF") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 103)\n  (:start . 98) (:id . 60))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 139) (:start . 124) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 170)\n  (:start . 159) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s402.10) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003682@unknown@formal@none@1@S@The GM-CSF locus may represent one of several target genes that are dysregulated in acute myeloid leukemia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "dysregulate") (:form . "dysregulated") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x402.11.1) (:span 17 20)))\n (:hscopes ((:id . :x402.11.1) (:span 17 106)))\n (:identifiers (:sid . :s402.11) (:did . :|96405269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003683@unknown@formal@none@1@S@Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.@(((:tag . "NNP") (:stem . "Tyloxapol") (:form . "Tyloxapol") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "scavenge") (:form . "scavenges") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "HOCI") (:form . "HOCI") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "viscosity") (:form . "viscosity") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cystic") (:form . "cystic") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "sputum") (:form . "sputum") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s403.1) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003684@unknown@formal@none@1@S@Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy.@(((:tag . "JJ") (:stem . "cystic") (:form . "Cystic") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CF") (:form . "CF") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "progressive") (:form . "progressive") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "cytokine-mediated") (:form . "cytokine-mediated")\n  (:end . 67) (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 80)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 119)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "thick") (:form . "thick") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tenacious") (:form . "tenacious") (:end . 139)\n  (:start . 130) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protease-") (:form . "protease-") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "oxidant-rich") (:form . "oxidant-rich") (:end . 167)\n  (:start . 155) (:id . 65))\n ((:tag . "JJ") (:stem . "purulent") (:form . "purulent") (:end . 176)\n  (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "airway") (:form . "airway") (:end . 183)\n  (:start . 177) (:id . 67))\n ((:tag . "NNS") (:stem . "secretion") (:form . "secretions") (:end . 194)\n  (:start . 184) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 199) (:start . 195)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 213)\n  (:start . 204) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 216) (:start . 214)\n  (:id . 72))\n ((:tag . "VB") (:stem . "clear") (:form . "clear") (:end . 222)\n  (:start . 217) (:id . 73))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 232) (:start . 228)\n  (:id . 75))\n ((:tag . "NN") (:stem . "physiotherapy") (:form . "physiotherapy")\n  (:end . 246) (:start . 233) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s403.2) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003685@unknown@formal@none@1@S@In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 55) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tyloxapol") (:form . "tyloxapol") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alkylaryl") (:form . "alkylaryl") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "polyether") (:form . "polyether") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "alcohol") (:form . "alcohol") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "polymer") (:form . "polymer") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "detergent") (:form . "detergent") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mucolytic") (:form . "mucolytic") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "bronchitis") (:form . "bronchitis") (:end . 180)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s403.3) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003686@unknown@formal@none@1@S@Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide ( LPS ) -stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4).@(((:tag . "NNP") (:stem . "Tyloxapol") (:form . "Tyloxapol") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . 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"and") (:end . 412) (:start . 409)\n  (:id . 107))\n ((:tag . "NN") (:stem . "leukotriene") (:form . "leukotriene") (:end . 424)\n  (:start . 413) (:id . 108))\n ((:tag . "NN") (:stem . "b4") (:form . "B4") (:end . 427) (:start . 425)\n  (:id . 109))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 429) (:start . 428)\n  (:id . 110))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 433) (:start . 429)\n  (:id . 111))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 434) (:start . 433)\n  (:id . 112))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 435) (:start . 434)\n  (:id . 113)))@@@1@72@((:identifiers (:sid . :s403.4) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003687@unknown@formal@none@1@S@We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tyloxapol") (:form . "tyloxapol") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hydroxyl") (:form . "hydroxyl") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "radical") (:form . "radicals") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "OH") (:form . "OH") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s403.5) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003688@unknown@formal@none@1@S@Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats.@(((:tag . "NNP") (:stem . "Tyloxapol") (:form . "Tyloxapol") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wt/vol") (:form . "wt/vol") (:end . 30)\n  (:start . 24) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 43)\n  (:start . 32) (:id . 50))\n ((:tag . "VBZ") (:stem . "scavenge") (:form . "scavenges") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "hypochlorous") (:form . "hypochlorous") (:end . 78)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "CD") (:stem . "7.5") (:form . "7.5") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mm") (:form . "mM") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 112)\n  (:start . 107) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 126)\n  (:start . 118) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 131) (:start . 127)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "hocl-mediated") (:form . "HOCl-mediated")\n  (:end . 145) (:start . 132) (:id . 70))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 150) (:start . 146)\n  (:id . 71))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 157)\n  (:start . 151) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 165) (:start . 161)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s403.6) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003690@unknown@formal@none@1@S@We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyloxapol") (:form . "tyloxapol") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 74) (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CF") (:form . "CF") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "secretion") (:form . "secretions") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CF") (:form . "CF") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "airway") (:form . "airway") (:end . 171)\n  (:start . 165) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x403.8.1) (:span 114 122))\n  ((:id . :x403.8.2) (:span 108 113)) ((:id . :x403.8.3) (:span 30 41)))\n (:hscopes ((:id . :x403.8.1) (:span 114 171))\n  ((:id . :x403.8.2) (:span 108 171)) ((:id . :x403.8.3) (:span 30 102)))\n (:identifiers (:sid . :s403.8) (:did . :|96406504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003691@unknown@formal@none@1@S@Abnormality of Oct-1 DNA binding in T cells from Sjogren 's syndrome patients.@(((:tag . "NN") (:stem . "abnormality") (:form . "Abnormality") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sjogren") (:form . "Sjogren") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s404.1) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003692@unknown@formal@none@1@S@Primary Sjogren 's syndrome (SS) is an autoimmune rheumatic disease characterized by T cell hypoactivity.@(((:tag . "JJ") (:stem . "primary") (:form . "Primary") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Sjogren") (:form . "Sjogren") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 49)\n  (:start . 39) (:id . 51))\n ((:tag . "JJ") (:stem . "rheumatic") (:form . "rheumatic") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hypoactivity") (:form . "hypoactivity") (:end . 104)\n  (:start . 92) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s404.2) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003693@unknown@formal@none@1@S@To understand the diminished T cell response to activation signals, we measured nucleoprotein DNA-binding activities regulating gene expression during T cell activation using the electrophoretic mobility shift assay.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "nucleoprotein") (:form . "nucleoprotein")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 127)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 132) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 150)\n  (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 168)\n  (:start . 158) (:id . 64))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 174) (:start . 169)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 194) (:start . 179) (:id . 67))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 203)\n  (:start . 195) (:id . 68))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 209)\n  (:start . 204) (:id . 69))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 215)\n  (:start . 210) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s404.3) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003694@unknown@formal@none@1@S@Peripheral blood lymphocytes from 9/19 SS patients were found to be defective in their ability to bind an october sequence (Oct-1).@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "9/19") (:form . "9/19") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "october") (:form . "october") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s404.4) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003695@unknown@formal@none@1@S@This Oct-1-binding phenotype remained stable in culture for up to 3 days prior to activation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "oct-1-binding") (:form . "Oct-1-binding")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 44)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "prior") (:form . "prior") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s404.5) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003696@unknown@formal@none@1@S@This abnormality was not seen in resting T cells nor T cells from patients with systemic lupus erythematosus, rheumatoid arthritis (RA), or SS accompanied by RA.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "erythematosus") (:form . "erythematosus")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 154)\n  (:start . 143) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x404.6.1) (:span 21 24 49 52)))\n (:nscopes ((:id . :x404.6.1) (:span 0 160)))\n (:identifiers (:sid . :s404.6) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003697@unknown@formal@none@1@S@The SS Oct-1 DNA-binding abnormality correlated significantly with an inability of cells to exit the Gzero/G1 cell cycle phase when stimulated in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 61) (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "VB") (:stem . "exit") (:form . "exit") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gzero/g1") (:form . "Gzero/G1") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s404.7) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003698@unknown@formal@none@1@S@Importantly, nucleoprotein extracts showing decreased DNA-binding activity had normal amounts of Oct-1 proteins as determined by immunoprecipitation, implying a functional defect in the Oct-1 protein.@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nucleoprotein") (:form . "nucleoprotein")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 65)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 78) (:start . 75)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 85)\n  (:start . 79) (:id . 51))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 93)\n  (:start . 86) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 125)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 148) (:start . 129) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "imply") (:form . "implying") (:end . 158)\n  (:start . 150) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 171)\n  (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 178)\n  (:start . 172) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 66))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 191)\n  (:start . 186) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 199)\n  (:start . 192) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x404.8.1) (:span 150 158)))\n (:hscopes ((:id . :x404.8.1) (:span 150 199)))\n (:identifiers (:sid . :s404.8) (:did . :|96409256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003700@unknown@formal@none@1@S@Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings.@(((:tag . "JJ") (:stem . "severe") (:form . "Severe") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 32) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "sibling") (:form . "siblings") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s405.1) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003701@unknown@formal@none@1@S@Peripheral blood lymphocytes (PBL) and alloreactive T cell lines of two male infants born to consanguinous parents and presenting with severe combined immunodeficiency (SCID) showed a pronounced deficiency in T cell activation.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "alloreactive") (:form . "alloreactive") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "infant") (:form . "infants") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "VBN") (:stem . "bear") (:form . "born") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "consanguinous") (:form . "consanguinous")\n  (:end . 106) (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "parent") (:form . "parents") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "present") (:form . "presenting") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 167) (:start . 151) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "SCID") (:form . "SCID") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 181)\n  (:start . 175) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 205)\n  (:start . 195) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 210) (:start . 209)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 215) (:start . 211)\n  (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 226)\n  (:start . 216) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s405.2) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003702@unknown@formal@none@1@S@Although phenotypically normal, the proliferative response of the childrens ' T cells was strongly reduced but could be improved by the addition of interleukin-2 (IL-2).@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "phenotypically") (:form . "phenotypically")\n  (:end . 23) (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 30)\n  (:start . 24) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "children") (:form . "childrens") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 161) (:start . 148) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s405.3) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003703@unknown@formal@none@1@S@Furthermore both childrens ' T cells were unable to produce the cytokines IL-2, interferon-gamma (IFN-gamma), IL-4 and tumor necrosis factor-alpha (TNF-alpha).@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "children") (:form . "childrens") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 96) (:start . 80) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 146)\n  (:start . 134) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x405.4.1) (:span 42 48)))\n (:nscopes ((:id . :x405.4.1) (:span 42 158)))\n (:identifiers (:sid . :s405.4) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003704@unknown@formal@none@1@S@This multiple cytokine production deficiency could not be restored by IL-2 or co-stimulatory signals provided by antigen-presenting cells (APC).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "restore") (:form . "restored") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "co-stimulatory") (:form . "co-stimulatory")\n  (:end . 92) (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 131) (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x405.5.1) (:span 45 54)))\n (:nscopes ((:id . :x405.5.1) (:span 0 143)))\n (:identifiers (:sid . :s405.5) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003705@unknown@formal@none@1@S@Moreover, mRNA for IL-2 and IFN-gamma could not be detected.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x405.6.1) (:span 38 47)))\n (:nscopes ((:id . :x405.6.1) (:span 10 59)))\n (:identifiers (:sid . :s405.6) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003706@unknown@formal@none@1@S@In contrast, expression of the activation-dependent cell surface markers CD25 and CD69 was within normal limits.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 51) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "CD25") (:form . "CD25") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD69") (:form . "CD69") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "limit") (:form . "limits") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s405.7) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003707@unknown@formal@none@1@S@To determine whether the functional defect of the patients ' T cells was due to the absence or abnormal binding of transcription factors involved in cytokine gene expression, electrophoretic mobility shift assays were used to examine the DNA binding of AP-1, Oct, CREB, SP1, NF-kappa B and the nuclear factor of activated T cells (NF-AT) to their respective response elements in the promoter of the IL-2 gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "defect") (:form . 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5003708@unknown@formal@none@1@S@Whereas AP-1, NF-kappa B, Oct, CREB and SP1 displayed normal binding activities in nuclear extracts, the binding of NF-AT to its IL-2 promoter response element was barely detectable both before and after T cell stimulation.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 35) (:start . 31)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SP1") (:form . "SP1") (:end . 43) (:start . 40)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 53)\n  (:start . 44) (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 60)\n  (:start . 54) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 68)\n  (:start . 61) (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 142)\n  (:start . 134) (:id . 68))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 151)\n  (:start . 143) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 159)\n  (:start . 152) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 163) (:start . 160)\n  (:id . 71))\n ((:tag . "RB") (:stem . "barely") (:form . "barely") (:end . 170)\n  (:start . 164) (:id . 72))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 181)\n  (:start . 171) (:id . 73))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 186) (:start . 182)\n  (:id . 74))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 193)\n  (:start . 187) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 76))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 203)\n  (:start . 198) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 205) (:start . 204)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 210) (:start . 206)\n  (:id . 79))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 222)\n  (:start . 211) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s405.9) (:did . :|96409274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003710@unknown@formal@none@1@S@Requirements for induction of vitamin D-mediated gene regulation in normal human B lymphocytes.@(((:tag . "NNS") (:stem . "requirement") (:form . "Requirements") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "d-mediated") (:form . "D-mediated") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s406.1) (:did . :|96413233|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003711@unknown@formal@none@1@S@Mature human lymphocytes are unique targets of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3) in that vitamin D receptors (VDR) are not constitutively expressed, and specific cellular activation signals are required for both the up-regulation of VDR and establishment of reactivity to the lipophilic ligand.@(((:tag . "JJ") (:stem . "mature") (:form . "Mature") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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5003712@unknown@formal@none@1@S@Treatment of B lymphocytes with the cytokine IL-4 (IL-4), in the absence of prior activation, induces a weak up-regulation of VDR expression but fails to generate vitamin D-responsive element ( VDRE ) -reactive nuclear protein complexes or to initiate the genomic transcription of 25-hydroxyvitamin D3 24-hydroxylase.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . 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5003713@unknown@formal@none@1@S@Stimulation of B lymphocytes by either ligation of CD40 Ag or cross-linking the Ig receptor is also insufficient to render B lymphocytes responsive to 1 alpha,25(OH)2D3.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "cross-linke") (:form . "cross-linking") (:end . 75)\n  (:start . 62) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 112)\n  (:start . 100) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "VB") (:stem . "render") (:form . "render") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 147)\n  (:start . 137) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "CD") (:stem . "alpha,25(OH)2D3") (:form . "alpha,25(OH)2D3")\n  (:end . 168) (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s406.4) (:did . :|96413233|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5003715@unknown@formal@none@1@S@In the presence of 1 alpha,25(OH)2D3, cellular activation associated with stimulation of such a progression appears to be sufficient for the up-regulation of VDR message and protein and necessary for the establishment of VDRE binding complexes and the induction of 24-hydroxylase message.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "alpha,25(OH)2D3") (:form . "alpha,25(OH)2D3")\n  (:end . 36) (:start . 21) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 154) (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 195)\n  (:start . 186) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "establishment") (:form . "establishment")\n  (:end . 217) (:start . 204) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "VDRE") (:form . "VDRE") (:end . 225) (:start . 221)\n  (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 233)\n  (:start . 226) (:id . 77))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 243)\n  (:start . 234) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 251) (:start . 248)\n  (:id . 80))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 261)\n  (:start . 252) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 264) (:start . 262)\n  (:id . 82))\n ((:tag . "NN") (:stem . "24-hydroxylase") (:form . "24-hydroxylase")\n  (:end . 279) (:start . 265) (:id . 83))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 287)\n  (:start . 280) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x406.6.1) (:span 108 115)))\n (:hscopes ((:id . :x406.6.1) (:span 38 287)))\n (:identifiers (:sid . :s406.6) (:did . :|96413233|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003716@unknown@formal@none@1@S@Furthermore, biologic functions are modulated, in that the hormone inhibits proliferation in a subset of the activated B cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s406.7) (:did . :|96413233|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003717@unknown@formal@none@1@S@These observations suggest that reactivity to 1 alpha,25(OH)2D3 is tightly regulated in B lymphocytes, requiring specific signals for its initiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "CD") (:stem . "alpha,25(OH)2D3") (:form . "alpha,25(OH)2D3")\n  (:end . 63) (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 129)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x406.8.1) (:span 19 26)))\n (:hscopes ((:id . :x406.8.1) (:span 19 148)))\n (:identifiers (:sid . :s406.8) (:did . :|96413233|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003718@unknown@formal@none@1@S@Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN.@(((:tag . "JJ") (:stem . "cell-type-specific") (:form . "Cell-type-specific")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 29)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "ATF-2/JUN") (:form . "ATF-2/JUN") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s407.1) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003720@unknown@formal@none@1@S@In both cases, induction of TNF-alpha gene transcription can be blocked by the immunosuppressants cyclosporin A and FK506, which suggested a role for the NFAT family of proteins in the regulation of the gene in B cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 97) (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 165)\n  (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 195)\n  (:start . 185) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 207) (:start . 203)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 212) (:start . 211)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x407.3.1) (:span 129 138)))\n (:hscopes ((:id . :x407.3.1) (:span 129 218)))\n (:identifiers (:sid . :s407.3) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003721@unknown@formal@none@1@S@Furthermore, in T cells, two molecules of NFATp bind to the TNF-alpha promoter element kappa 3 in association with ATF-2 and Jun proteins bound to an immediately adjacent cyclic AMP response element (CRE) site.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 69)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 109)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ATF-2") (:form . "ATF-2") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 66))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 161)\n  (:start . 150) (:id . 70))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 170)\n  (:start . 162) (:id . 71))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 177)\n  (:start . 171) (:id . 72))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 190)\n  (:start . 182) (:id . 74))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 198)\n  (:start . 191) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 200) (:start . 199)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 203) (:start . 200)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 78))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 209) (:start . 205)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s407.4) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003722@unknown@formal@none@1@S@Here, using the murine B-cell lymphoma cell line A20, we show that the TNF-alpha gene is regulated in a cell-type-specific manner.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "a20") (:form . "A20") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 80)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 98)\n  (:start . 89) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 122) (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 129)\n  (:start . 123) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s407.5) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003723@unknown@formal@none@1@S@In A20 B cells, the TNF-alpha gene is not regulated by NFATp bound to the kappa 3 element.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "A20") (:form . "A20") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 29)\n  (:start . 20) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 51)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 79) (:start . 74)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 89)\n  (:start . 82) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x407.6.1) (:span 38 41)))\n (:nscopes ((:id . :x407.6.1) (:span 16 89)))\n (:identifiers (:sid . :s407.6) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003724@unknown@formal@none@1@S@Instead, ATF-2 and Jun proteins bind to the composite kappa 3/CRE site and NFATp binds to a newly identified second NFAT site centered at -76 nucleotides relative to the TNF-alpha transcription start site.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "ATF-2") (:form . "ATF-2") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "3/cre") (:form . "3/CRE") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nfatp") (:form . "NFATp") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 108)\n  (:start . 98) (:id . 61))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "centered") (:form . "centered") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-76") (:form . "-76") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 153)\n  (:start . 142) (:id . 68))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 179)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 193) (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 199)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 204) (:start . 200)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s407.7) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003725@unknown@formal@none@1@S@This new site plays a critical role in the calcium-mediated, cyclosporin A-sensitive induction of TNF-alpha in both A20 B cells and Ar-5 cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "calcium-mediated") (:form . "calcium-mediated")\n  (:end . 59) (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "a-sensitive") (:form . "A-sensitive") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "A20") (:form . "A20") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ar-5") (:form . "Ar-5") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s407.8) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003726@unknown@formal@none@1@S@Consistent with these results, quantitative DNase footprinting of the TNF-alpha promoter using increasing amounts of recombinant NFATp demonstrated that the -76 site binds to NFATp with a higher affinity than the kappa 3 site.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "quantitative") (:form . "quantitative") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 62)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 128)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "nfatp") (:form . "NFATp") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 147)\n  (:start . 135) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "CD") (:stem . "-76") (:form . "-76") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nfatp") (:form . "NFATp") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 194)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 203)\n  (:start . 195) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 208) (:start . 204)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 73))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 218)\n  (:start . 213) (:id . 74))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 220) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 225) (:start . 221)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s407.9) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003727@unknown@formal@none@1@S@Two other previously unrecognized NFATp-binding sites in the proximal TNF-alpha promoter were also identified by this analysis.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "unrecognized") (:form . "unrecognized") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "nfatp-binding") (:form . "NFATp-binding")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 53) (:start . 48)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 93) (:start . 89)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 109)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s407.10) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003728@unknown@formal@none@1@S@Thus, through the differential use of the same promoter element, the composite kappa 3/CRE site, the TNF-alpha gene is regulated in a cell-type-specific manner in response to the same extracellular signal.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "3/cre") (:form . "3/CRE") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 152) (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 197) (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s407.11) (:did . :|96413274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003730@unknown@formal@none@1@S@Three subtypes of retinoic acid receptors (RAR), termed RAR alpha, RAR beta, and RAR gamma, have been described.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "subtype") (:form . "subtypes") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 55) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 84) (:start . 81)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 90) (:start . 85)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 96) (:start . 92)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 101) (:start . 97)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 111)\n  (:start . 102) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s408.2) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003731@unknown@formal@none@1@S@They are composed of different structural domains, including distinct domains for DNA and ligand binding.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s408.3) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003732@unknown@formal@none@1@S@RARs specifically bind all-trans-retinoic acid (RA), 9-cis-RA, and retinoid analogs.@(((:tag . "NNP") (:stem . "RAR") (:form . "RARs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "all-trans-retinoic") (:form . "all-trans-retinoic")\n  (:end . 41) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 46) (:start . 42)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "9-cis-RA") (:form . "9-cis-RA") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "analog") (:form . "analogs") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s408.4) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003733@unknown@formal@none@1@S@In this study, we examined the functional role of cysteine and arginine residues in the ligand-binding domain of hRAR alpha (hRAR alpha-LBD, amino acids 154 to 462).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "arginine") (:form . "arginine") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ligand-binding") (:form . "ligand-binding")\n  (:end . 102) (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "hRAR") (:form . "hRAR") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "hRAR") (:form . "hRAR") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha-lbd") (:form . "alpha-LBD") (:end . 139)\n  (:start . 130) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "CD") (:stem . "154") (:form . "154") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "CD") (:stem . "462") (:form . "462") (:end . 163) (:start . 160)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s408.5) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003734@unknown@formal@none@1@S@All conserved cysteine and arginine residues in this domain were mutated by site-directed mutagenesis, and the mutant proteins were characterized by blocking reactions, ligand-binding experiments, transactivation assays, and protease mapping.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "arginine") (:form . "arginine") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "site-directed") (:form . "site-directed")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 145) (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 167)\n  (:start . 158) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ligand-binding") (:form . "ligand-binding")\n  (:end . 183) (:start . 169) (:id . 67))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 195)\n  (:start . 184) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 212) (:start . 197) (:id . 70))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 219)\n  (:start . 213) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 73))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 233)\n  (:start . 225) (:id . 74))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 241)\n  (:start . 234) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s408.6) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003735@unknown@formal@none@1@S@Changes of any cysteine residue of the hRAR alpha-LBD had no significant influence on the binding of all-trans RA or 9-cis RA.@(((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "hRAR") (:form . "hRAR") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha-lbd") (:form . "alpha-LBD") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s408.7) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003736@unknown@formal@none@1@S@Interestingly, residue C-235 is specifically important in antagonist binding.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "c-235") (:form . "C-235") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s408.8) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003737@unknown@formal@none@1@S@With respect to arginine residues, only the two single mutations of R-276 and R-394 to alanine showed a dramatic decrease of agonist and antagonist binding whereas the R272A mutation showed only a slight effect.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "arginine") (:form . "arginine") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "R-276") (:form . "R-276") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "r-394") (:form . "R-394") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alanine") (:form . "alanine") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 147)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "R272A") (:form . "R272A") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 182)\n  (:start . 174) (:id . 71))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 189)\n  (:start . 183) (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 203)\n  (:start . 197) (:id . 75))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 210)\n  (:start . 204) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s408.9) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003738@unknown@formal@none@1@S@For all other arginine mutations, no differences in affinity were detectable.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "arginine") (:form . "arginine") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x408.10.1) (:span 34 36)))\n (:nscopes ((:id . :x408.10.1) (:span 34 76)))\n (:identifiers (:sid . :s408.10) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003740@unknown@formal@none@1@S@From these results, we can conclude that electrostatic interactions of retinoids with the RAR alpha-LBD play a significant role in ligand binding.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VB") (:stem . "conclude") (:form . "conclude") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "electrostatic") (:form . "electrostatic")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha-lbd") (:form . "alpha-LBD") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x408.12.1) (:span 23 26)))\n (:hscopes ((:id . :x408.12.1) (:span 23 145)))\n (:identifiers (:sid . :s408.12) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003741@unknown@formal@none@1@S@In addition, antagonists show distinctly different requirements for efficient binding, which may contribute to their interference in the ligand-inducible transactivation function of RAR alpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "distinctly") (:form . "distinctly") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 129)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ligand-inducible") (:form . "ligand-inducible")\n  (:end . 153) (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 169) (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 178)\n  (:start . 170) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 185) (:start . 182)\n  (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 191)\n  (:start . 186) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x408.13.1) (:span 93 96)))\n (:hscopes ((:id . :x408.13.1) (:span 93 191)))\n (:identifiers (:sid . :s408.13) (:did . :|96413288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003742@unknown@formal@none@1@S@Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.@(((:tag . "NNP") (:stem . "Cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 28) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 91) (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 112)\n  (:start . 106) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 132)\n  (:start . 121) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 158)\n  (:start . 153) (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 166)\n  (:start . 159) (:id . 63))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 170) (:start . 167)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 176)\n  (:start . 171) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 179) (:start . 177)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "polymeras") (:form . "polymerases") (:end . 195)\n  (:start . 184) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 70))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 206) (:start . 203)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s409.1) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003743@unknown@formal@none@1@S@The proximal sequence element ( PSE ) -binding transcription factor (PTF), which binds the PSE of both RNA polymerase II- and RNA polymerase III-transcribed mammalian small nuclear RNA (snRNA) genes, is essential for their transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PSE") (:form . "PSE") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "-binding") (:form . "-binding") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PTF") (:form . "PTF") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PSE") (:form . "PSE") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 117)\n  (:start . 107) (:id . 63))\n ((:tag . "NNP") (:stem . "II-") (:form . "II-") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 140)\n  (:start . 130) (:id . 67))\n ((:tag . "JJ") (:stem . "iii-transcribed") (:form . "III-transcribed")\n  (:end . 156) (:start . 141) (:id . 68))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "snRNA") (:form . "snRNA") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 198)\n  (:start . 193) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 202) (:start . 200)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 212)\n  (:start . 203) (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 216) (:start . 213)\n  (:id . 80))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 222)\n  (:start . 217) (:id . 81))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 236) (:start . 223) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s409.2) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003744@unknown@formal@none@1@S@We previously reported the purification of human PTF, a complex of four subunits, and the molecular cloning and characterization of PTF gamma and delta subunits.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "purification") (:form . "purification") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PTF") (:form . "PTF") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 128) (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PTF") (:form . "PTF") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s409.3) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003745@unknown@formal@none@1@S@Here we describe the isolation and expression of a cDNA encoding PTF beta, as well as functional studies using anti-PTF beta antibodies.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "ptf") (:form . "PTF") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 96)\n  (:start . 86) (:id . 59))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 110) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-ptf") (:form . "anti-PTF") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s409.4) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003746@unknown@formal@none@1@S@Native PTF beta, in either protein fractions or a PTF-Oct-1-DNA complex, can be recognized by polyclonal antibodies raised against recombinant PTF beta.@(((:tag . "JJ") (:stem . "native") (:form . "Native") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ptf") (:form . "PTF") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PTF-Oct-1-DNA") (:form . "PTF-Oct-1-DNA")\n  (:end . 63) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "NNP") (:stem . "PTF") (:form . "PTF") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s409.5) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003747@unknown@formal@none@1@S@Immunodepletion studies show that PTF beta is required for transcription of both classes of snRNA genes in vitro.@(((:tag . "NN") (:stem . "immunodepletion") (:form . "Immunodepletion")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PTF") (:form . "PTF") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "snrna") (:form . "snRNA") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s409.6) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003748@unknown@formal@none@1@S@In addition, immunoprecipitation analyses demonstrate that substantial and similar molar amounts of TATA-binding protein (TBP) and TFIIIB90 can weakly associate with PTF at low salt conditions, but this association is dramatically reduced at high salt concentrations.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 32) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 70)\n  (:start . 59) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "JJ") (:stem . "molar") (:form . "molar") (:end . 88) (:start . 83)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "tata-binding") (:form . "TATA-binding") (:end . 112)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 120)\n  (:start . 113) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TFIIIB90") (:form . "TFIIIB90") (:end . 139)\n  (:start . 131) (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PTF") (:form . "PTF") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "salt") (:form . "salt") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 192)\n  (:start . 182) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 202) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 214)\n  (:start . 203) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 230)\n  (:start . 218) (:id . 76))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 238)\n  (:start . 231) (:id . 77))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 241) (:start . 239)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 246) (:start . 242)\n  (:id . 79))\n ((:tag . "NN") (:stem . "salt") (:form . "salt") (:end . 251) (:start . 247)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 266) (:start . 252) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s409.7) (:did . :|96413292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003750@unknown@formal@none@1@S@Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 97)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s410.1) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003751@unknown@formal@none@1@S@Engagement of surface immunoglobulin on mature B cells leads to rescue from apoptosis and to proliferation.@(((:tag . "NN") (:stem . "engagement") (:form . "Engagement") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 36) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 106) (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s410.2) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003752@unknown@formal@none@1@S@Levels of bcl-2 mRNA and protein increase with cross-linking of surface immunoglobulin.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 86) (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s410.3) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003753@unknown@formal@none@1@S@We have located the major positive regulatory region for control of bcl-2 expression in B cells in the 5'-flanking region.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s410.4) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003754@unknown@formal@none@1@S@The positive region can be divided into an upstream and a downstream regulatory region.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s410.5) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003755@unknown@formal@none@1@S@The downstream regulatory region contains a cyclic AMP-responsive element (CRE).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "amp-responsive") (:form . "AMP-responsive")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s410.6) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003756@unknown@formal@none@1@S@We show by antibody supershift experiments and UV cross-linking followed by denaturing polyacrylamide gel electrophoresis that both CREB and ATF family members bind to this region in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "denature") (:form . "denaturing") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "polyacrylamide") (:form . "polyacrylamide")\n  (:end . 101) (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 121) (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 131) (:start . 127)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 136) (:start . 132)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "ATF") (:form . "ATF") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 151)\n  (:start . 145) (:id . 62))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 159)\n  (:start . 152) (:id . 63))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 164) (:start . 160)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s410.7) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003757@unknown@formal@none@1@S@Mutations of the CRE site that result in loss of CREB binding also lead to loss of functional activity of the bcl-2 promoter in transient-transfection assays.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 93)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transient-transfection")\n  (:form . "transient-transfection") (:end . 150) (:start . 128) (:id . 66))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 157)\n  (:start . 151) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s410.8) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003758@unknown@formal@none@1@S@The presence of an active CRE site in the bcl-2 promoter implies that the regulation of bcl-2 expression is linked to a signal transduction pathway in B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "cre") (:form . "CRE") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 139)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 152) (:start . 151)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x410.9.1) (:span 57 64)))\n (:hscopes ((:id . :x410.9.1) (:span 57 158)))\n (:identifiers (:sid . :s410.9) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003760@unknown@formal@none@1@S@Treatment of the more immature B-cell line, Ramos, with phorbol esters rescues the cells from calcium-dependent apoptosis.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ramos") (:form . "Ramos") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "VBZ") (:stem . "rescue") (:form . "rescues") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 111) (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s410.11) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003761@unknown@formal@none@1@S@bcl-2 expression is increased following phorbol ester treatment, and the increased expression is dependent on the CRE site.@(((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s410.12) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003762@unknown@formal@none@1@S@These stimuli result in phosphorylation of CREB at serine 133.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s410.13) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003763@unknown@formal@none@1@S@The phosphorylation of CREB that results in activation is mediated by protein kinase C rather than by protein kinase A.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x410.14.1) (:span 87 98)))\n (:nscopes ((:id . :x410.14.1) (:span 87 118)))\n (:identifiers (:sid . :s410.14) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003764@unknown@formal@none@1@S@Although the CRE site is necessary, optimal induction of bcl-2 expression requires participation of the upstream regulatory element, suggesting that phosphorylation of CREB alters its interaction with the upstream regulatory element.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 96) (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 164) (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 195)\n  (:start . 184) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 213)\n  (:start . 205) (:id . 72))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 224)\n  (:start . 214) (:id . 73))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 232)\n  (:start . 225) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x410.15.1) (:span 133 143)))\n (:hscopes ((:id . :x410.15.1) (:span 133 232)))\n (:identifiers (:sid . :s410.15) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003765@unknown@formal@none@1@S@The CRE site in the bcl-2 promoter appears to play a major role in the induction of bcl-2 expression during the activation of mature B cells and during the rescue of immature B cells from apoptosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 80)\n  (:start . 71) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 132)\n  (:start . 126) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 151)\n  (:start . 145) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 70))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 162)\n  (:start . 156) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 174)\n  (:start . 166) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 187) (:start . 183)\n  (:id . 76))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 197)\n  (:start . 188) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x410.16.1) (:span 35 42)))\n (:hscopes ((:id . :x410.16.1) (:span 0 197)))\n (:identifiers (:sid . :s410.16) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003766@unknown@formal@none@1@S@It is possible that the CRE site is responsible for induction of bcl-2 expression in other cell types, particularly those in which protein kinase C is involved.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 47)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 115)\n  (:start . 103) (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 145)\n  (:start . 139) (:id . 66))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x410.17.1) (:span 6 14)))\n (:hscopes ((:id . :x410.17.1) (:span 6 159)))\n (:identifiers (:sid . :s410.17) (:did . :|96413305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003767@unknown@formal@none@1@S@Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein.@(((:tag . "NNP") (:stem . "Interleukin-6") (:form . "Interleukin-6")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 71) (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 89) (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s411.1) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003768@unknown@formal@none@1@S@Interleukin-6 (IL-6) mediates autocrine and paracrine growth of multiple myeloma (MM) cells and inhibits tumor cell apoptosis.@(((:tag . "NNP") (:stem . "Interleukin-6") (:form . "Interleukin-6")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "paracrine") (:form . "paracrine") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s411.2) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003770@unknown@formal@none@1@S@Because dephosphorylated (activated) pRB blocks transition from G1 to S phase of the cell cycle whereas phosphorylated (inactivated) pRB releases this growth arrest, we characterized the role of pRB in IL-6-mediated MM cell growth.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 24) (:start . 8) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 118) (:start . 104) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "inactivate") (:form . "inactivated") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "release") (:form . "releases") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 157)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 182) (:start . 169) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 191) (:start . 187)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "pRB") (:form . "pRB") (:end . 198) (:start . 195)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "il-6-mediated") (:form . "IL-6-mediated")\n  (:end . 215) (:start . 202) (:id . 77))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 218) (:start . 216)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 223) (:start . 219)\n  (:id . 79))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 230)\n  (:start . 224) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s411.4) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003771@unknown@formal@none@1@S@Both phosphorylated and dephosphorylated pRB were expressed in all serum-starved MM patient cells and MM-derived cell lines, but pRB was predominantly in its phosphorylated form.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 40) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "serum-starved") (:form . "serum-starved")\n  (:end . 80) (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mm-derived") (:form . "MM-derived") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "pRB") (:form . "pRB") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 150) (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 172) (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s411.5) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003772@unknown@formal@none@1@S@In MM cells that proliferated in response to IL-6, exogenous IL-6 downregulated dephosphorylated pRB and decreased dephosphorylated pRB-E2F complexes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "proliferate") (:form . "proliferated") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 96) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 131) (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "prb-e2f") (:form . "pRB-E2F") (:end . 139)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 149)\n  (:start . 140) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s411.6) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003773@unknown@formal@none@1@S@Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells;@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RB") (:form . "RB") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RB") (:form . "RB") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 85) (:start . 70) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "ODN") (:form . "ODN") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "trigger") (:form . "triggered") (:end . 101)\n  (:start . 92) (:id . 61))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 116)\n  (:start . 107) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 134) (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 147) (:start . 146)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x411.7.1) (:span 56 59)))\n (:nscopes ((:id . :x411.7.1) (:span 56 68)))\n (:identifiers (:sid . :s411.7) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003774@unknown@formal@none@1@S@however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb).@(((:tag . "RB") (:stem . "however") (:form . "however") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 67)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "anti-il-6") (:form . "anti-IL-6") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 88)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MoAb") (:form . "MoAb") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s411.8) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003775@unknown@formal@none@1@S@In contrast to MM cells, normal splenic B cells express dephosphorylated pRB.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 72) (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s411.9) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003776@unknown@formal@none@1@S@Although CD40 ligand (CD40L) triggers a shift from dephosphorylated to phosphorylated pRB and proliferation of B cells, the addition of exogenous IL-6 to CD40L-treated B cells does not alter either pRB or proliferation, as observed in MM cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 67) (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 85) (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cd40l-treated") (:form . "CD40L-treated")\n  (:end . 167) (:start . 154) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 190)\n  (:start . 185) (:id . 73))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 197)\n  (:start . 191) (:id . 74))\n ((:tag . "NN") (:stem . "prb") (:form . "pRB") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 204) (:start . 202)\n  (:id . 76))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 218) (:start . 205) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 222) (:start . 220)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 231)\n  (:start . 223) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 234) (:start . 232)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 243)\n  (:start . 238) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x411.10.1) (:span 181 184)))\n (:nscopes ((:id . :x411.10.1) (:span 181 218)))\n (:identifiers (:sid . :s411.10) (:did . :|96420243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003777@unknown@formal@none@1@S@These results suggest that phosphorylated pRB is constitutively expressed in MM cells and that IL-6 further shifts pRB from its dephosphorylated to its phosphorylated form, thereby promoting MM cell growth via two mechanisms; by decreasing the amount of E2F bound by dephosphorylated pRB due to reduced dephosphorylated pRB, thereby releasing growth arrest; and by upregulating IL-6 secretion by MM cells and related IL-6-mediated autocrine tumor cell growth.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 41) (:start . 27) (:id . 46))\n ((:tag . 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5003778@unknown@formal@none@1@S@JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes.@(((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 60)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s412.1) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003780@unknown@formal@none@1@S@However, the mechanisms involved in the activation of AP-1 by antioxidants are largely unknown.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s412.3) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003781@unknown@formal@none@1@S@In this study we show that the structurally unrelated antioxidant agents pyrrolidine dithiocarbamate (PDTC), butylated hydroxyanisole, and Nacetylcysteine activated JNK (c-Jun NH2-terminal kinase) in Jurkat T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 43)\n  (:start . 31) (:id . 49))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 100) (:start . 85) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "butylate") (:form . "butylated") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "hydroxyanisole") (:form . "hydroxyanisole")\n  (:end . 133) (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Nacetylcysteine") (:form . "Nacetylcysteine")\n  (:end . 154) (:start . 139) (:id . 63))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 164)\n  (:start . 155) (:id . 64))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 175)\n  (:start . 170) (:id . 67))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 188)\n  (:start . 176) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 195)\n  (:start . 189) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 206)\n  (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 208) (:start . 207)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 214)\n  (:start . 209) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s412.4) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003782@unknown@formal@none@1@S@This activation differed substantially from that mediated by phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophore or produced by costimulation with antibodies against the T cell receptor-CD3 complex and to CD28.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 38) (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 81)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 146) (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 162)\n  (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 170)\n  (:start . 163) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "receptor-cd3") (:form . "receptor-CD3") (:end . 194)\n  (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 202)\n  (:start . 195) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 214) (:start . 210)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s412.5) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003783@unknown@formal@none@1@S@The activation of JNK by classical T cell stimuli was transient, whereas that mediated by PDTC and butylated hydroxyanisole (but not N-acetylcysteine) was sustained.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "butylate") (:form . "butylated") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "hydroxyanisole") (:form . "hydroxyanisole")\n  (:end . 123) (:start . 109) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 149) (:start . 133) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 164)\n  (:start . 155) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x412.6.1) (:span 129 132)))\n (:nscopes ((:id . :x412.6.1) (:span 129 149)))\n (:identifiers (:sid . :s412.6) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003784@unknown@formal@none@1@S@The kinetics of JNK activation correlated with the expression of c-jun which was transient after stimulation with PMA plus ionophore and prolonged in response to PDTC, which also transiently induced c-fos.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "prolong") (:form . "prolonged") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 190)\n  (:start . 179) (:id . 71))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 198)\n  (:start . 191) (:id . 72))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 204)\n  (:start . 199) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s412.7) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003785@unknown@formal@none@1@S@In addition, JNK activation by PMA plus ionophore was sensitive to inhibitors of signaling pathways involving Ca2+, protein kinase C, and tyrosine phosphorylation, which failed to inhibit the activation mediated by PDTC.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NNP") (:stem . "Ca2+") (:form . "Ca2+") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 162) (:start . 147) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 187)\n  (:start . 180) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 202)\n  (:start . 192) (:id . 74))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 211)\n  (:start . 203) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 214) (:start . 212)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 219) (:start . 215)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x412.8.1) (:span 170 176)))\n (:nscopes ((:id . :x412.8.1) (:span 170 219)))\n (:identifiers (:sid . :s412.8) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003786@unknown@formal@none@1@S@Transfection of trans-dominant negative expression vectors of ras and raf, together with AP-1-dependent reporter constructs, as well as Western blot analysis using anti-ERK (extracellular signal-regulated kinase) antibodies, indicated that the Ras/Raf/ERK pathway did not appear to mediate the effect of the antioxidant.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "trans-dominant") (:form . "trans-dominant")\n  (:end . 30) (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 58)\n  (:start . 51) (:id . 47))\n ((:tag . "IN") (:stem . 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5003787@unknown@formal@none@1@S@However, the combined treatment with PDTC and PMA, two agents that synergize on AP-1 activation, resulted in the persistent phosphorylation of ERK-2.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 139) (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "erk-2") (:form . "ERK-2") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s412.10) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003788@unknown@formal@none@1@S@In conclusion, our results identify JNK as a target of antioxidant agents which can be regulated differentially under oxidant and antioxidant conditions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "jnk") (:form . "JNK") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 111) (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 141)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s412.11) (:did . :|96421639|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003790@unknown@formal@none@1@S@Complications after lung transplantation include the development of rejection and an increased incidence of infection, particularly with cytomegalovirus (CMV).@(((:tag . "NNS") (:stem . "complication") (:form . "Complications")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 19) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 40) (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 48)\n  (:start . 41) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 64)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "incidence") (:form . "incidence") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 57))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 131)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 152) (:start . 137) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 157) (:start . 154)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s413.2) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003791@unknown@formal@none@1@S@Several recent studies have suggested that interleukin ( IL ) -6 may be used to detect both infection and rejection after lung transplantation.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL") (:form . "IL") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-6") (:form . "-6") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 115)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 142) (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x413.3.1) (:span 65 68)) ((:id . :x413.3.2) (:span 28 37)))\n (:hscopes ((:id . :x413.3.1) (:span 65 142))\n  ((:id . :x413.3.2) (:span 28 142)))\n (:identifiers (:sid . :s413.3) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003792@unknown@formal@none@1@S@In addition, IL-6 may play a role in the development of bronchiolitis obliterans after transplantation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 52)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bronchiolitis") (:form . "bronchiolitis")\n  (:end . 69) (:start . 56) (:id . 54))\n ((:tag . "NNS") (:stem . "obliteran") (:form . "obliterans") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 102) (:start . 87) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x413.4.1) (:span 18 21)))\n (:hscopes ((:id . :x413.4.1) (:span 18 102)))\n (:identifiers (:sid . :s413.4) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003793@unknown@formal@none@1@S@Because CMV is also associated with the development of bronchiolitis obliterans after transplantation, we determined whether CMV induces IL-6 gene expression.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bronchiolitis") (:form . "bronchiolitis")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "obliteran") (:form . "obliterans") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 101) (:start . 86) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x413.5.1) (:span 117 124)))\n (:hscopes ((:id . :x413.5.1) (:span 117 157)))\n (:identifiers (:sid . :s413.5) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003794@unknown@formal@none@1@S@We demonstrated that CMV infection increased both IL-6 protein and mRNA in peripheral blood mononuclear cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s413.6) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003795@unknown@formal@none@1@S@We also demonstrated that the CMV immediate early 1 gene product increased expression of the IL-6 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s413.7) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003796@unknown@formal@none@1@S@This effect of the CMV immediate early 1 gene product was dependent upon the presence of specific transcription factor binding sites in the IL-6 promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s413.8) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003797@unknown@formal@none@1@S@These studies demonstrate that CMV may be an important cofactor in the development of rejection and infection after transplantation through its effects on IL-6.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 131) (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x413.9.1) (:span 35 38)))\n (:hscopes ((:id . :x413.9.1) (:span 35 159)))\n (:identifiers (:sid . :s413.9) (:did . :|96427516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003798@unknown@formal@none@1@S@E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.@(((:tag . "NNP") (:stem . "E3") (:form . "E3") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 5) (:start . 4)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 28) (:start . 6) (:id . 45))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s414.1) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003800@unknown@formal@none@1@S@We have used differential hybridization analysis of a cDNA library constructed from the murine RA-inducible MPRO promyelocyte cell line to identify immediate-early genes induced by RA during granulocytic differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "ra-inducible") (:form . "RA-inducible") (:end . 107)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "mpro") (:form . "MPRO") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 125)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 163) (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 169)\n  (:start . 164) (:id . 64))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 177)\n  (:start . 170) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 190)\n  (:start . 184) (:id . 68))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 203)\n  (:start . 191) (:id . 69))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 219) (:start . 204) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s414.3) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003801@unknown@formal@none@1@S@E3, one of nine sequences identified, was upregulated in an immediate-early manner, with transcript levels peaking after 60 minutes exposure to RA.@(((:tag . "NNP") (:stem . "E3") (:form . "E3") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 7) (:start . 4)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 45))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 15) (:start . 11)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 25)\n  (:start . 16) (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 53)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 75) (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "VBG") (:stem . "peak") (:form . "peaking") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s414.4) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003802@unknown@formal@none@1@S@E3 transcripts were RA-inducible in HL60 cells, but not in an RA-resistant subclone, HL60R, that harbors a mutated RAR alpha gene.@(((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ra-inducible") (:form . "RA-inducible") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ra-resistant") (:form . "RA-resistant") (:end . 74)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "subclone") (:form . "subclone") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HL60R") (:form . "HL60R") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "harbor") (:form . "harbors") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x414.5.1) (:span 52 55)))\n (:nscopes ((:id . :x414.5.1) (:span 52 129)))\n (:identifiers (:sid . :s414.5) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003803@unknown@formal@none@1@S@However, when HL60R cells were transduced with a functional copy of the RAR alpha gene, RA induced a 10-fold increase in E3 mRNA levels.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HL60R") (:form . "HL60R") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "copy") (:form . "copy") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "10-fold") (:form . "10-fold") (:end . 108)\n  (:start . 101) (:id . 62))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 135)\n  (:start . 129) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s414.6) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003804@unknown@formal@none@1@S@E3 transcripts are present in the myeloid, B-lymphoid, and erythroid lineages, absent in nonhematopoietic cells, and encode a highly hydrophobic, potentially phosphorylated polypeptide of unknown function with significant homology to a putative protein expressed in myeloid cells.@(((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "b-lymphoid") (:form . "B-lymphoid") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 105) (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "hydrophobic") (:form . "hydrophobic") (:end . 144)\n  (:start . 133) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 157)\n  (:start . 146) (:id . 67))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 172) (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 184)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 195)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 209) (:start . 205)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 221)\n  (:start . 210) (:id . 74))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 230)\n  (:start . 222) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 233) (:start . 231)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 235) (:start . 234)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 244)\n  (:start . 236) (:id . 78))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 252)\n  (:start . 245) (:id . 79))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 262)\n  (:start . 253) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 265) (:start . 263)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 273)\n  (:start . 266) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 279)\n  (:start . 274) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x414.7.1) (:span 236 244))\n  ((:id . :x414.7.2) (:span 146 157)))\n (:hscopes ((:id . :x414.7.1) (:span 236 252))\n  ((:id . :x414.7.2) (:span 146 172)))\n (:identifiers (:sid . :s414.7) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003805@unknown@formal@none@1@S@The murine E3 promoter harbors a single bipartite retinoic acid response element which in transient transfection assays conferred RA sensitivity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "harbor") (:form . "harbors") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 112)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s414.8) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003806@unknown@formal@none@1@S@These results indicate that E3 is a hematopoietic-specific gene that is an immediate target for the activated RAR alpha during myelopoiesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 58) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x414.9.1) (:span 14 27)))\n (:hscopes ((:id . :x414.9.1) (:span 14 139)))\n (:identifiers (:sid . :s414.9) (:did . :|96437028|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003807@unknown@formal@none@1@S@Interstitial deletion constitutes the major mechanism for loss of heterozygosity on chromosome 20q in polycythemia vera.@(((:tag . "JJ") (:stem . "interstitial") (:form . "Interstitial") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "VBZ") (:stem . "constitute") (:form . "constitutes") (:end . 33)\n  (:start . 22) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "heterozygosity") (:form . "heterozygosity")\n  (:end . 80) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "20q") (:form . "20q") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "polycythemia") (:form . "polycythemia") (:end . 114)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "vera") (:form . "vera") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s415.1) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003808@unknown@formal@none@1@S@An acquired deletion of the long arm of chromosome 20 is a recurrent abnormality in myeloproliferative disorders, particularly polycythemia vera and myelodysplastic syndromes.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "arm") (:form . "arm") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "abnormality") (:form . "abnormality") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "myeloproliferative") (:form . "myeloproliferative")\n  (:end . 102) (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 126)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "polycythemia") (:form . "polycythemia") (:end . 139)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "vera") (:form . "vera") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "myelodysplastic") (:form . "myelodysplastic")\n  (:end . 164) (:start . 149) (:id . 64))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 174)\n  (:start . 165) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s415.2) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003810@unknown@formal@none@1@S@We have recently performed a detailed molecular analysis of 20q deletions in peripheral blood (PB) granulocytes and defined a commonly deleted region of 16 to 21 centimorgan (cM).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "20q") (:form . "20q") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PB") (:form . "PB") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 111)\n  (:start . 99) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "define") (:form . "defined") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "centimorgan") (:form . "centimorgan") (:end . 173)\n  (:start . 162) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "cM") (:form . "cM") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s415.4) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003811@unknown@formal@none@1@S@To further reduce the size of the common deleted region we have searched for small deletions or mitotic recombination events, neither of which would be detected by conventional cytogenetics.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "reduce") (:form . "reduce") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "search") (:form . "searched") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mitotic") (:form . "mitotic") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "conventional") (:form . "conventional") (:end . 176)\n  (:start . 164) (:id . 70))\n ((:tag . "NNS") (:stem . "cytogenetic") (:form . "cytogenetics") (:end . 189)\n  (:start . 177) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x415.5.1) (:span 126 133)))\n (:nscopes ((:id . :x415.5.1) (:span 126 189)))\n (:identifiers (:sid . :s415.5) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003812@unknown@formal@none@1@S@We have studied 48 patients with polycythemia vera and four patients with idiopathic myelofibrosis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "polycythemia") (:form . "polycythemia") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "vera") (:form . "vera") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "idiopathic") (:form . "idiopathic") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "myelofibrosis") (:form . "myelofibrosis")\n  (:end . 98) (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s415.6) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003813@unknown@formal@none@1@S@In each case, cytogenetic analysis had either failed or had shown no abnormalities of chromosome 20.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cytogenetic") (:form . "cytogenetic") (:end . 25)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 52) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 82)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x415.7.1) (:span 66 68)))\n (:nscopes ((:id . :x415.7.1) (:span 66 99)))\n (:identifiers (:sid . :s415.7) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003814@unknown@formal@none@1@S@Seventeen microsatellite markers that span the common deleted region were used to search for loss of heterozygosity in granulocyte DNA.@(((:tag . "CD") (:stem . "seventeen") (:form . "Seventeen") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "microsatellite") (:form . "microsatellite")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "span") (:form . "span") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VB") (:stem . "search") (:form . "search") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "heterozygosity") (:form . "heterozygosity")\n  (:end . 115) (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 130)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s415.8) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003815@unknown@formal@none@1@S@No instance of microsatellite instability was observed in a total of 880 comparisons of granulocyte and T-cell DNA.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "microsatellite") (:form . "microsatellite")\n  (:end . 29) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "instability") (:form . "instability") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "880") (:form . "880") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x415.9.1) (:span 0 2)))\n (:nscopes ((:id . :x415.9.1) (:span 0 114)))\n (:identifiers (:sid . :s415.9) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003816@unknown@formal@none@1@S@Granulocyte DNA from four patients exhibited allele loss on 20q.@(((:tag . "NNP") (:stem . "Granulocyte") (:form . "Granulocyte") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "20q") (:form . "20q") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s415.10) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003817@unknown@formal@none@1@S@In each case the allele loss was caused by an interstitial deletion because heterozygosity at distal markers was retained and because quantitative Southern blotting demonstrated hemizygosity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "interstitial") (:form . "interstitial") (:end . 58)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "heterozygosity") (:form . "heterozygosity")\n  (:end . 90) (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "quantitative") (:form . "quantitative") (:end . 146)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "southern") (:form . "Southern") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 177)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "hemizygosity") (:form . "hemizygosity") (:end . 190)\n  (:start . 178) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s415.11) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003818@unknown@formal@none@1@S@Loss of heterozygosity in PB granulocytes would be masked by the presence of significant numbers of normal granulocytes not derived from the malignant clone.@(((:tag . "NN") (:stem . "loss") (:form . "Loss") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "heterozygosity") (:form . "heterozygosity")\n  (:end . 22) (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PB") (:form . "PB") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mask") (:form . "masked") (:end . 57) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 119)\n  (:start . 107) (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 156)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x415.12.2) (:span 42 47)))\n (:ncues ((:id . :x415.12.1) (:span 120 123)))\n (:hscopes ((:id . :x415.12.2) (:span 0 156)))\n (:nscopes ((:id . :x415.12.1) (:span 120 156)))\n (:identifiers (:sid . :s415.12) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003820@unknown@formal@none@1@S@In 21 of 27 informative female patients the majority of the granulocytes were clonally derived.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "informative") (:form . "informative") (:end . 23)\n  (:start . 12) (:id . 46))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "RB") (:stem . "clonally") (:form . "clonally") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s415.14) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003821@unknown@formal@none@1@S@In 5 patients the granulocytes appeared polyclonal and in 1 patient unilateral X inactivation was observed in both granulocytes and T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 13)\n  (:start . 5) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "unilateral") (:form . "unilateral") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 93)\n  (:start . 81) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x415.15.1) (:span 31 39)))\n (:hscopes ((:id . :x415.15.1) (:span 31 50)))\n (:identifiers (:sid . :s415.15) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003822@unknown@formal@none@1@S@These results show that , in the vast majority of patients presented here, the failure to detect loss of heterozygosity can not be attributed to the presence of normal polyclonal granulocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "vast") (:form . "vast") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "heterozygosity") (:form . "heterozygosity")\n  (:end . 119) (:start . 105) (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 167)\n  (:start . 161) (:id . 71))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 191)\n  (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x415.16.2) (:span 120 127))\n  ((:id . :x415.16.1) (:span 79 86)))\n (:nscopes ((:id . :x415.16.2) (:span 79 119))\n  ((:id . :x415.16.1) (:span 79 191)))\n (:identifiers (:sid . :s415.16) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003823@unknown@formal@none@1@S@Our results therefore show that allele loss on chromosome 20q in polycythemia vera does not commonly involve mitotic recombination or chromosome loss and that microsatellite instability is a rare event in this disorder.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "20q") (:form . "20q") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "polycythemia") (:form . "polycythemia") (:end . 77)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "vera") (:form . "vera") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "mitotic") (:form . "mitotic") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "microsatellite") (:form . "microsatellite")\n  (:end . 173) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "instability") (:form . "instability") (:end . 185)\n  (:start . 174) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 188) (:start . 186)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 190) (:start . 189)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 195) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 201)\n  (:start . 196) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 209) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 218)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x415.17.1) (:span 88 91)))\n (:nscopes ((:id . :x415.17.1) (:span 88 149)))\n (:identifiers (:sid . :s415.17) (:did . :|96437048|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003824@unknown@formal@none@1@S@Transcriptional control of steroid-regulated apoptosis in murine thymoma cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "steroid-regulated") (:form . "steroid-regulated")\n  (:end . 44) (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 54)\n  (:start . 45) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 64)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "thymoma") (:form . "thymoma") (:end . 72)\n  (:start . 65) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s416.1) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003825@unknown@formal@none@1@S@Early studies in murine T cell lines indicated that transcriptional transactivation functions encoded in the glucocorticoid receptor (GR) N-terminal domain are required for glucocorticoid-mediated apoptosis.@(((:tag . "JJ") (:stem . "early") (:form . "Early") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 67) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 83) (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 101)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 123) (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 155)\n  (:start . 149) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 168)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "glucocorticoid-mediated") (:end . 196) (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 206)\n  (:start . 197) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x416.2.1) (:span 37 51)))\n (:hscopes ((:id . :x416.2.1) (:span 37 206)))\n (:identifiers (:sid . :s416.2) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003826@unknown@formal@none@1@S@However, more recent studies in human T cell lines have suggested that the N-terminal domain is not necessary for steroid-regulated apoptosis and that GR-mediated transrepression may be the more critical mechanism.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "steroid-regulated") (:form . "steroid-regulated")\n  (:end . 131) (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 141)\n  (:start . 132) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "gr-mediated") (:form . "GR-mediated") (:end . 162)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "transrepression") (:form . "transrepression")\n  (:end . 178) (:start . 163) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 194) (:start . 190)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 203)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 213)\n  (:start . 204) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x416.3.1) (:span 179 182))\n  ((:id . :x416.3.3) (:span 56 65)))\n (:ncues ((:id . :x416.3.2) (:span 96 99)))\n (:hscopes ((:id . :x416.3.1) (:span 179 213))\n  ((:id . :x416.3.3) (:span 56 213)))\n (:nscopes ((:id . :x416.3.2) (:span 96 141)))\n (:identifiers (:sid . :s416.3) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003827@unknown@formal@none@1@S@To better understand the contribution of the GR N-terminal transactivation domain in mediating murine thymocyte apoptosis, we stably transfected GR, GR variants, and the androgen receptor (AR) into receptor-negative S49 murine thymoma cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 74) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "VBD") (:stem . "transfecte") (:form . "transfected") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "AR") (:form . "AR") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 73))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "receptor-negative") (:form . "receptor-negative")\n  (:end . 215) (:start . 198) (:id . 75))\n ((:tag . "NNP") (:stem . "S49") (:form . "S49") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 226)\n  (:start . 220) (:id . 77))\n ((:tag . "NN") (:stem . "thymoma") (:form . "thymoma") (:end . 234)\n  (:start . 227) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s416.4) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003828@unknown@formal@none@1@S@GR expression levels were shown to be rate-limiting for initiating the apoptotic pathway, and a positive correlation between steroid sensitivity and GR-mediated induction of an integrated mouse mammary tumor virus (MMTV) LTR reporter gene was observed.@(((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rate-limiting") (:form . "rate-limiting")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "initiate") (:form . "initiating") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 116)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 144)\n  (:start . 133) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "gr-mediated") (:form . "GR-mediated") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 170)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 187)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 193)\n  (:start . 188) (:id . 69))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 201)\n  (:start . 194) (:id . 70))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 207)\n  (:start . 202) (:id . 71))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 213)\n  (:start . 208) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 215) (:start . 214)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "MMTV") (:form . "MMTV") (:end . 219) (:start . 215)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 224) (:start . 221)\n  (:id . 76))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 233)\n  (:start . 225) (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 238) (:start . 234)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 242) (:start . 239)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 251)\n  (:start . 243) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s416.5) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003830@unknown@formal@none@1@S@In contrast, we found that AR can initiate apoptosis in S49 cells after treatment with 5 alpha-dihydrotestosterone, despite its relative inability to induce high level expression of MMTV.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ar") (:form . "AR") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 42)\n  (:start . 34) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "s49") (:form . "S49") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha-dihydrotestosterone")\n  (:form . "alpha-dihydrotestosterone") (:end . 114) (:start . 89) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 146)\n  (:start . 137) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "MMTV") (:form . "MMTV") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s416.7) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003831@unknown@formal@none@1@S@To investigate this further, we examined the steroid-regulated expression of an endogenous thymocyte-specific gene called GIG18.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "steroid-regulated") (:form . "steroid-regulated")\n  (:end . 62) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "thymocyte-specific") (:form . "thymocyte-specific")\n  (:end . 109) (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "gig18") (:form . "GIG18") (:end . 127)\n  (:start . 122) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s416.8) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003832@unknown@formal@none@1@S@We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and , moreover , that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gig18") (:form . "GIG18") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AR") (:form . "AR") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 93)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ar") (:form . "AR") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "RB") (:stem . "indeed") (:form . "indeed") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 142) (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "s49") (:form . "S49") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "RB") (:stem . "moreover") (:form . "moreover") (:end . 180)\n  (:start . 172) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gig18") (:form . "GIG18") (:end . 193)\n  (:start . 188) (:id . 76))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 203)\n  (:start . 194) (:id . 77))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 210) (:start . 208)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 212) (:start . 211)\n  (:id . 80))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 219)\n  (:start . 213) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 228)\n  (:start . 223) (:id . 83))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 238)\n  (:start . 229) (:id . 84))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 245)\n  (:start . 239) (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 248) (:start . 246)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "steroid-treated") (:form . "steroid-treated")\n  (:end . 264) (:start . 249) (:id . 87))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 270)\n  (:start . 265) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x416.9.1) (:span 204 207)))\n (:hscopes ((:id . :x416.9.1) (:span 204 270)))\n (:identifiers (:sid . :s416.9) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003833@unknown@formal@none@1@S@Taken together, these results support our conclusion that transcriptional transactivation is a necessary signaling component of S49 cell apoptosis, although an additional role for GR-mediated transrepression cannot be excluded.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 89) (:start . 74) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "S49") (:form . "S49") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 146)\n  (:start . 137) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "gr-mediated") (:form . "GR-mediated") (:end . 191)\n  (:start . 180) (:id . 68))\n ((:tag . "NN") (:stem . "transrepression") (:form . "transrepression")\n  (:end . 207) (:start . 192) (:id . 69))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 214)\n  (:start . 208) (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 217) (:start . 215)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "exclude") (:form . "excluded") (:end . 226)\n  (:start . 218) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x416.10.1) (:span 208 226))\n  ((:id . :x416.10.2) (:span 42 52)))\n (:hscopes ((:id . :x416.10.1) (:span 157 226))\n  ((:id . :x416.10.2) (:span 42 146)))\n (:identifiers (:sid . :s416.10) (:did . :|97000328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003834@unknown@formal@none@1@S@Suppression of c-jun by antisense oligonucleotides inhibits cell adhesion but not respiratory burst during phorbol ester-induced differentiation of U937 human monoblastic cells.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 50) (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 93)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 114)\n  (:start . 107) (:id . 56))\n ((:tag . "JJ") (:stem . "ester-induced") (:form . "ester-induced")\n  (:end . 128) (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 144) (:start . 129) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 59))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 152) (:start . 148)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 158)\n  (:start . 153) (:id . 61))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 170)\n  (:start . 159) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x417.1.1) (:span 78 81)))\n (:nscopes ((:id . :x417.1.1) (:span 78 99)))\n (:identifiers (:sid . :s417.1) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003835@unknown@formal@none@1@S@We studied the role of the immediate early gene c-jun in cell proliferation and phorbol 12-myristate 13-acetate ( PMA ) -induced differentiation in U937 human monoblastic cells, using c-jun-specific antisense (AS) phosphorothioate oligonucleotides.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 75) (:start . 62) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "-induced") (:form . "-induced") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 144) (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 170)\n  (:start . 159) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 183) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "c-jun-specific") (:form . "c-jun-specific")\n  (:end . 198) (:start . 184) (:id . 71))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 208)\n  (:start . 199) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 230) (:start . 214) (:id . 76))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 247) (:start . 231) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s417.2) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003836@unknown@formal@none@1@S@In selecting the most specific and potent oligonucleotide sequence, we performed extensive analyses for the binding specificity between all candidates of c-jun AS oligonucleotides and the whole sequences in GenBank database, using a computer program.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "select") (:form . "selecting") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 179) (:start . 163) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 193)\n  (:start . 188) (:id . 69))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 203)\n  (:start . 194) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 214)\n  (:start . 207) (:id . 72))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 223)\n  (:start . 215) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 224) (:start . 223)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 230) (:start . 225)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 232) (:start . 231)\n  (:id . 76))\n ((:tag . "NN") (:stem . "computer") (:form . "computer") (:end . 241)\n  (:start . 233) (:id . 77))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 249)\n  (:start . 242) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s417.3) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003837@unknown@formal@none@1@S@Among the 20 selected oligonucleotides, two potent 15-mer AS oligonucleotides (C-JUN AS oligonucleotides) exhibited significant inhibition of cell growth in a dose-dependent manner between 2 and 10 microM.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 38) (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "15-mer") (:form . "15-mer") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 77) (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C-JUN") (:form . "C-JUN") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 104) (:start . 88) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 173) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 180)\n  (:start . 174) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 190) (:start . 189)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 204)\n  (:start . 198) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s417.4) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003838@unknown@formal@none@1@S@Reverse transcription-PCR and Western blot analysis demonstrated that 10 microM of C-JUN AS oligonucleotides reduced c-jun expression at both the mRNA and protein levels.@(((:tag . "JJ") (:stem . "reverse") (:form . "Reverse") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "transcription-PCR") (:form . "transcription-PCR")\n  (:end . 25) (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Western") (:form . "Western") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 64)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C-JUN") (:form . "C-JUN") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 108) (:start . 92) (:id . 55))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 116)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 136) (:start . 134)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 169)\n  (:start . 163) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s417.5) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003840@unknown@formal@none@1@S@the C-JUN AS oligonucleotides inhibited cell adhesion, whereas they did not affect another marker of differentiation, respiratory burst (measured by nitro blue tetrazolium reduction assay).@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C-JUN") (:form . "C-JUN") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "as") (:form . "AS") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 29) (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 116) (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nitro") (:form . "nitro") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tetrazolium") (:form . "tetrazolium") (:end . 171)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x417.7.1) (:span 72 75)))\n (:nscopes ((:id . :x417.7.1) (:span 72 188)))\n (:identifiers (:sid . :s417.7) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003841@unknown@formal@none@1@S@These results suggest a critical role of c-jun in both cell proliferation and PMA-induced cell adhesion but not in PMA-induced respiratory burst in U937 cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 126)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 138)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x417.8.2) (:span 14 21)))\n (:ncues ((:id . :x417.8.1) (:span 108 111)))\n (:hscopes ((:id . :x417.8.2) (:span 14 158)))\n (:nscopes ((:id . :x417.8.1) (:span 108 158)))\n (:identifiers (:sid . :s417.8) (:did . :|97006603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003842@unknown@formal@none@1@S@Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TAFII") (:form . "TAFII") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "105") (:form . "105") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 39) (:start . 26) (:id . 48))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "htafii130") (:form . "hTAFII130") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s418.1) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003843@unknown@formal@none@1@S@We previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TAF") (:form . "TAF") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tfiid") (:form . "TFIID") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s418.2) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003844@unknown@formal@none@1@S@Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 35) (:start . 21) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "substoichiometric") (:form . "substoichiometric")\n  (:end . 77) (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "taf") (:form . "TAF") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "105") (:form . "105") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x418.3.1) (:span 93 96)))\n (:nscopes ((:id . :x418.3.1) (:span 93 155)))\n (:identifiers (:sid . :s418.3) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003845@unknown@formal@none@1@S@The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "encoding") (:form . "encoding") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "htafii105") (:form . "hTAFII105") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "htafii130") (:form . "hTAFII130") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "otafii110") (:form . "oTAFII110") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 147)\n  (:start . 141) (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "diverge") (:form . "diverged") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 174) (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s418.4) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003846@unknown@formal@none@1@S@All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 16) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "tafii105") (:form . "TAFII105") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s418.5) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003847@unknown@formal@none@1@S@Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "htafii105") (:form . "hTAFII105") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 49)\n  (:start . 38) (:id . 46))\n ((:tag . "VBZ") (:stem . "squelch") (:form . "squelches") (:end . 59)\n  (:start . 50) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 85) (:start . 81)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 91) (:start . 86)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s418.6) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003848@unknown@formal@none@1@S@These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tafii105") (:form . "TAFII105") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 157)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x418.7.1) (:span 85 88)) ((:id . :x418.7.2) (:span 17 24)))\n (:hscopes ((:id . :x418.7.1) (:span 85 168))\n  ((:id . :x418.7.2) (:span 17 168)))\n (:identifiers (:sid . :s418.7) (:did . :|97011146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003850@unknown@formal@none@1@S@We describe two female monozygotic (MZ) twins heterozygous for Fabry disease, an X linked disorder resulting from the deficient activity of alpha-galactosidase A.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "monozygotic") (:form . "monozygotic") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mz") (:form . "MZ") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "twin") (:form . "twins") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 58)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Fabry") (:form . "Fabry") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 89) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha-galactosidase")\n  (:form . "alpha-galactosidase") (:end . 159) (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s419.2) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003851@unknown@formal@none@1@S@While one of the twins was clinically affected, the other was asymptomatic.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "twin") (:form . "twins") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "asymptomatic") (:form . "asymptomatic") (:end . 74)\n  (:start . 62) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s419.3) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003852@unknown@formal@none@1@S@Enzymatic assay of alpha-galactosidase in blood leucocytes, skin fibroblasts, Epstein-Barr virus transformed lymphoid cell lines, and hair follicles of the twins and their parents confirmed the heterozygous status of the twins and indicated that Fabry disease had occurred as a result of a de novo mutation.@(((:tag . "JJ") (:stem . "enzymatic") (:form . "Enzymatic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha-galactosidase")\n  (:form . "alpha-galactosidase") (:end . 38) (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . 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"FW") (:stem . "novo") (:form . "novo") (:end . 297) (:start . 293)\n  (:id . 89))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 306)\n  (:start . 298) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x419.4.1) (:span 231 245)))\n (:hscopes ((:id . :x419.4.1) (:span 231 306)))\n (:identifiers (:sid . :s419.4) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003853@unknown@formal@none@1@S@The son of the unaffected twin sister was shown to be hemizygous.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "son") (:form . "son") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 25)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "twin") (:form . "twin") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sister") (:form . "sister") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hemizygous") (:form . "hemizygous") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s419.5) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003854@unknown@formal@none@1@S@Molecular analysis of the alpha-galactosidase A gene permitted the identification of an as yet undescribed point mutation at position 10182 of exon 5 which causes an Asp to Asn substitution at codon 231.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha-galactosidase")\n  (:form . "alpha-galactosidase") (:end . 45) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "permit") (:form . "permitted") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 81) (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "undescribed") (:form . "undescribed") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "CD") (:stem . "10182") (:form . "10182") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "asp") (:form . "Asp") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Asn") (:form . "Asn") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 189)\n  (:start . 177) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 198)\n  (:start . 193) (:id . 73))\n ((:tag . "CD") (:stem . "231") (:form . "231") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s419.6) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003855@unknown@formal@none@1@S@Single strand conformation polymorphism (SSCP) analysis again showed the heterozygous status of the twins and a normal pattern in their parents.@(((:tag . "JJ") (:stem . "single") (:form . "Single") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 39)\n  (:start . 27) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SSCP") (:form . "SSCP") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 68) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "twin") (:form . "twins") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "parent") (:form . "parents") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s419.7) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003856@unknown@formal@none@1@S@The basis for the discordant expression of this d novo mutation in the twins was investigated by studying their X inactivation status.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "discordant") (:form . "discordant") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "FW") (:stem . "d") (:form . "d") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "twin") (:form . "twins") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 93)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 126)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s419.8) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003857@unknown@formal@none@1@S@Analysis of the inactive X specific methylation at the androgen receptor gene showed unbalanced inactivation in the twins ' fibroblasts and in opposite directions.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 84) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unbalanced") (:form . "unbalanced") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "twin") (:form . "twins") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "direction") (:form . "directions") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s419.9) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003858@unknown@formal@none@1@S@While the maternally derived X chromosome was preferentially active in the asymptomatic twin, the paternal X chromosome was active in the other, affected twin and was found in her hemizygotic nephew.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "maternally") (:form . "maternally") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 60) (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "asymptomatic") (:form . "asymptomatic") (:end . 87)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "twin") (:form . "twin") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "paternal") (:form . "paternal") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "affected") (:form . "affected") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "twin") (:form . "twin") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "PRP$") (:stem . "her") (:form . "her") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "hemizygotic") (:form . "hemizygotic") (:end . 191)\n  (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "nephew") (:form . "nephew") (:end . 198)\n  (:start . 192) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s419.10) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003860@unknown@formal@none@1@S@This is the first documented case of female twins discordant for Fabry disease.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "twin") (:form . "twins") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "discordant") (:form . "discordant") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Fabry") (:form . "Fabry") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s419.12) (:did . :|97016536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003861@unknown@formal@none@1@S@Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNPS") (:stem . "JAK") (:form . "JAKs") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STATs") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 70)\n  (:start . 58) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 90) (:start . 74) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s420.1) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003862@unknown@formal@none@1@S@Cytokines that bind to the interleukin-2 (IL-2) receptor common gamma chain (gamma c), including IL-2, IL-4, IL-7, IL-9, and IL-15, are important for the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monoctyes.@(((:tag . "NNS") (:stem . "cytokine") (:form . "Cytokines") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . 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"and") (:end . 243) (:start . 240)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "monoctye") (:form . "monoctyes") (:end . 253)\n  (:start . 244) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s420.2) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003863@unknown@formal@none@1@S@These cytokines have overlapping biological effects that in part result from the use of the shared receptor subunit gamma c.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s420.3) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003864@unknown@formal@none@1@S@Recently it has become clear that these cytokines activate a number of important intracellular signaling molecules, including the Janus kinases JAK1 and JAK3 and members of the transcription factor family of signal transducers and activators of transcription (STATs).@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "become") (:form . "become") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "jak1") (:form . "JAK1") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 190) (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 197)\n  (:start . 191) (:id . 71))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 204)\n  (:start . 198) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 214)\n  (:start . 208) (:id . 74))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 226)\n  (:start . 215) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 241)\n  (:start . 231) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 244) (:start . 242)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 258) (:start . 245) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 260) (:start . 259)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 265)\n  (:start . 260) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 266) (:start . 265)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s420.4) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003865@unknown@formal@none@1@S@The discovery of these signaling pathways has led to important new insights into their role in lymphocyte maturation, as it has emerged that mutations in the genes encoding both gamma c and JAK3 result in similar forms of severe combined immunodeficiency (SCID).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "lead") (:form . "led") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 163)\n  (:start . 158) (:id . 69))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 172)\n  (:start . 164) (:id . 70))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 185) (:start . 184)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 201)\n  (:start . 195) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 212)\n  (:start . 205) (:id . 78))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 218)\n  (:start . 213) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 228)\n  (:start . 222) (:id . 81))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 237)\n  (:start . 229) (:id . 82))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 254) (:start . 238) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 256) (:start . 255)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "SCID") (:form . "SCID") (:end . 260) (:start . 256)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 261) (:start . 260)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s420.5) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003866@unknown@formal@none@1@S@In this review we examine the structure and function of cytokine receptors and the signaling pathways involved in their regulation of gene expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "examine") (:form . "examine") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s420.6) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003867@unknown@formal@none@1@S@Furthermore, we discuss recent advances that have led to a better understanding of how cytokines elicit intracellular responses, as well as their role in normal lymphoid development.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "advance") (:form . "advances") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "lead") (:form . "led") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 65) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "VBP") (:stem . "elicit") (:form . "elicit") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 117) (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 160)\n  (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 181)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s420.7) (:did . :|97017504|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003868@unknown@formal@none@1@S@Eosinophil priming by cytokines: from cellular signal to in vivo modulation.@(((:tag . "NNP") (:stem . "Eosinophil") (:form . "Eosinophil") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s421.1) (:did . :|97024832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003870@unknown@formal@none@1@S@This review will focus on the conversion of the unprimed eosinophil phenotype in the peripheral blood of normal individuals to the primed phenotype found in the peripheral blood and tissues of allergic patients, a phenomenon called priming.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "focus") (:form . "focus") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unprimed") (:form . "unprimed") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 171)\n  (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 189)\n  (:start . 182) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 201)\n  (:start . 193) (:id . 73))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 213) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 224)\n  (:start . 214) (:id . 77))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 239)\n  (:start . 232) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s421.3) (:did . :|97024832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003871@unknown@formal@none@1@S@Recent data on the signals initiated after cytokine receptor activation on eosinophils will be reviewed.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s421.4) (:did . :|97024832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003872@unknown@formal@none@1@S@Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cross-talk") (:form . "cross-talk") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 90) (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s422.1) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003873@unknown@formal@none@1@S@Despite the widespread use of glucocorticoids in the treatment of diseases characterized by inflammation, the molecular mechanism ( s ) by which these hormones exert this beneficial effect in patients with asthma remains to be elucidated.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "widespread") (:form . "widespread") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 45) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 88) (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 104)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 181)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 188)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 205) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 212)\n  (:start . 206) (:id . 74))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 220)\n  (:start . 213) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 223) (:start . 221)\n  (:id . 76))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 237)\n  (:start . 227) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s422.2) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003874@unknown@formal@none@1@S@Therefore, we have studied the transcriptional regulation of intercellular adhesion molecule-1 (ICAM-1) as adhesion molecules are likely to play a causal role in inflammation in promoting cell-cell and cell-matrix interactions.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 46) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "causal") (:form . "causal") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 174)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 187)\n  (:start . 178) (:id . 70))\n ((:tag . "JJ") (:stem . "cell-cell") (:form . "cell-cell") (:end . 197)\n  (:start . 188) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cell-matrix") (:form . "cell-matrix") (:end . 213)\n  (:start . 202) (:id . 73))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 226)\n  (:start . 214) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x422.3.1) (:span 130 136)))\n (:hscopes ((:id . :x422.3.1) (:span 107 226)))\n (:identifiers (:sid . :s422.3) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003875@unknown@formal@none@1@S@We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 54)\n  (:start . 45) (:id . 53))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 65)\n  (:start . 55) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h292") (:form . "H292") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cell-line") (:form . "cell-line") (:end . 82)\n  (:start . 73) (:id . 58))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 96) (:start . 83) (:id . 59))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 141)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s422.4) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003876@unknown@formal@none@1@S@Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).@(((:tag . "JJ") (:stem . "subsequent") (:form . "Subsequent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol")\n  (:form . "12-O-tetradecanoylphorbol") (:end . 97) (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 108)\n  (:start . 98) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 147)\n  (:start . 135) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 158)\n  (:start . 149) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "upregulate") (:form . "upregulate") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 177)\n  (:start . 171) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 188)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 196)\n  (:start . 189) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 69))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 209)\n  (:start . 201) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 214) (:start . 213)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 222)\n  (:start . 215) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 229)\n  (:start . 223) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 239)\n  (:start . 231) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 241) (:start . 240)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 242) (:start . 241)\n  (:id . 78))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 249)\n  (:start . 243) (:id . 79))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 258)\n  (:start . 250) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 260) (:start . 259)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "TGGAAATTCC") (:form . "TGGAAATTCC") (:end . 270)\n  (:start . 260) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 271) (:start . 270)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s422.5) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003877@unknown@formal@none@1@S@No glucocorticoid recognition sequences are present in this promoter region and dexamethasone is still able to repress transcription when the multimerized NF-kappa B sequence is transactivated by TNF-alpha upon transfection in 293 cells.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 93) (:start . 80) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 154)\n  (:start . 142) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 192) (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 195) (:start . 193)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 205)\n  (:start . 196) (:id . 69))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 210) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 223)\n  (:start . 211) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 72))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 230) (:start . 227)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 236)\n  (:start . 231) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x422.6.1) (:span 0 2)))\n (:nscopes ((:id . :x422.6.1) (:span 0 75)))\n (:identifiers (:sid . :s422.6) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003878@unknown@formal@none@1@S@We propose that direct interaction between the glucocorticoid receptor and nuclear factor-kappa B factors is at least a partial explanation for the effects of this hormone in inflammatory diseases.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 61) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 105)\n  (:start . 98) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 187)\n  (:start . 175) (:id . 69))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x422.7.1) (:span 3 10)))\n (:hscopes ((:id . :x422.7.1) (:span 3 196)))\n (:identifiers (:sid . :s422.7) (:did . :|97024837|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003880@unknown@formal@none@1@S@Direct evidence that N-acetylcysteine (NAC) enhances the immune response of peripheral blood T cells at the level of NF(kappa)B is presented.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 37) (:start . 21) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF(kappa)B") (:form . "NF(kappa)B") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s423.2) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003881@unknown@formal@none@1@S@In addition, NAC blocks the suppression of T cell mitogenesis and cytokine production by protease inhibitors such as N-tosylphenylalanine chloromethyl ketone (TPCK).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "N-tosylphenylalanine")\n  (:form . "N-tosylphenylalanine") (:end . 137) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "chloromethyl") (:form . "chloromethyl") (:end . 150)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "ketone") (:form . "ketone") (:end . 157)\n  (:start . 151) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 163) (:start . 159)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s423.3) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003882@unknown@formal@none@1@S@The proliferative responses of purified CD4+ or CD8+ T cells are suppressed more strongly by TPCK when anti-CD28 rather than the phorbol ester PMA is used as the mitogenic coactivator.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 171)\n  (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 183)\n  (:start . 172) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x423.4.1) (:span 113 124)))\n (:nscopes ((:id . :x423.4.1) (:span 113 146)))\n (:identifiers (:sid . :s423.4) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003883@unknown@formal@none@1@S@Cytokine (IL-2, IL-6, INF-gamma) production is inhibited 95-100% by concentrations of TPCK that totally suppress the mitogenesis of CD4+ or CD8+ cells.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "INF-gamma") (:form . "INF-gamma") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 43)\n  (:start . 33) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . "CD") (:stem . "95-100") (:form . "95-100") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 82) (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tpck") (:form . "TPCK") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 128)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s423.5) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003884@unknown@formal@none@1@S@Using electrophoretic mobility shift assays, we find that TPCK virtually abolishes (to less than 1%) the levels of NF(kappa)B (but not Oct-1) found in nuclear and whole cell extracts of activated T cells.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tpck") (:form . "TPCK") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 111)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF(kappa)B") (:form . "NF(kappa)B") (:end . 125)\n  (:start . 115) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 134) (:start . 131)\n  (:id . 67))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 147)\n  (:start . 142) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 158)\n  (:start . 151) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 168)\n  (:start . 163) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 173) (:start . 169)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 182)\n  (:start . 174) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 195)\n  (:start . 186) (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 197) (:start . 196)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x423.6.1) (:span 131 134)))\n (:nscopes ((:id . :x423.6.1) (:span 131 140)))\n (:identifiers (:sid . :s423.6) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003885@unknown@formal@none@1@S@Strikingly, the immunosuppressive effects of TPCK are blocked when T cells are pretreated for 15 min with 5 mM NAC.@(((:tag . "RB") (:stem . "strikingly") (:form . "Strikingly") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s423.7) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003886@unknown@formal@none@1@S@NAC not only blocks the effect of TPCK but enhances mitogenesis and cytokine production (> 2.5-fold in some cases) upon activation of unsuppressed T cells.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "2.5-fold") (:form . "2.5-fold") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 130)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unsuppressed") (:form . "unsuppressed") (:end . 146)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s423.8) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003887@unknown@formal@none@1@S@Our data support the notion that NF(kappa)B and I(kappa)B proteases play obligate roles in T cell activation and mitogenesis, roles that are enhanced significantly by NAC.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF(kappa)B") (:form . "NF(kappa)B") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "I(kappa)B") (:form . "I(kappa)B") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "obligate") (:form . "obligate") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 124)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 163) (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x423.9.1) (:span 21 27)))\n (:hscopes ((:id . :x423.9.1) (:span 21 170)))\n (:identifiers (:sid . :s423.9) (:did . :|97025418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003888@unknown@formal@none@1@S@IL-12-induced activation of NK and T cells occurs in the absence of immediate-early activation gene expression.@(((:tag . "JJ") (:stem . "il-12-induced") (:form . "IL-12-induced")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 83) (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s424.1) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003890@unknown@formal@none@1@S@Using reverse-transcription PCR differential display, we isolated an mRNA species expressed in IL-2- but not IL-12-stimulated NK cells.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reverse-transcription")\n  (:form . "reverse-transcription") (:end . 27) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 44)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "display") (:form . "display") (:end . 52)\n  (:start . 45) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-2-") (:form . "IL-2-") (:end . 100)\n  (:start . 95) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "il-12-stimulated") (:form . "IL-12-stimulated")\n  (:end . 125) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x424.3.1) (:span 105 108)))\n (:nscopes ((:id . :x424.3.1) (:span 105 134)))\n (:identifiers (:sid . :s424.3) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003891@unknown@formal@none@1@S@This was identified as the mRNA encoding the transcription factor egr-1, which is expressed with fast kinetics in T and NK cells upon IL-2, but not IL-12, stimulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fast") (:form . "fast") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 153)\n  (:start . 148) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 71))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 166)\n  (:start . 155) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x424.4.1) (:span 144 147)))\n (:nscopes ((:id . :x424.4.1) (:span 144 153)))\n (:identifiers (:sid . :s424.4) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003892@unknown@formal@none@1@S@Analysis of the accumulation of mRNA-encoding members of the AP-1 transcription factor family demonstrated that c-fos and junB are also expressed upon stimulation of NK and T cells with IL-2, but not IL-12, whereas expression of c-jun and junD is not modified by either cytokine.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mrna-encoding") (:form . "mRNA-encoding")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . 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5003893@unknown@formal@none@1@S@Accordingly, increased AP-1 DNA-binding activity and AP-1-dependent transcriptional activity were detected exclusively in IL-2-stimulated cells.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ap-1-dependent") (:form . "AP-1-dependent")\n  (:end . 67) (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 83) (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 97) (:start . 93)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 106)\n  (:start . 98) (:id . 53))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 118)\n  (:start . 107) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "il-2-stimulated") (:form . "IL-2-stimulated")\n  (:end . 137) (:start . 122) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s424.6) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003894@unknown@formal@none@1@S@Analysis of the expression of genes reported to regulate cytokine-induced proliferation demonstrated that both IL-2 and IL-12 induce c-myc mRNA accumulation in NK and T cells, whereas only IL-2 induces bcl-2 expression.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 73) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 100)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 110) (:start . 106)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 115) (:start . 111)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 125)\n  (:start . 120) (:id . 58))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 156)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 207)\n  (:start . 202) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 218)\n  (:start . 208) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s424.7) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003895@unknown@formal@none@1@S@Our data provide the first demonstration that IL-12-mediated activation of T and NK cells does not involve expression of members of the immediate-early activation genes family (egr-1, c-fos, and junB), AP-1 transcriptional activity, or bcl-2 expression.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "il-12-mediated") (:form . "IL-12-mediated")\n  (:end . 60) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 151) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 175)\n  (:start . 169) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 189)\n  (:start . 184) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 199) (:start . 195)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 206) (:start . 202)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 222) (:start . 207) (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 231)\n  (:start . 223) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 232) (:start . 231)\n  (:id . 80))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 235) (:start . 233)\n  (:id . 81))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 241)\n  (:start . 236) (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 252)\n  (:start . 242) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x424.8.1) (:span 95 98)))\n (:nscopes ((:id . :x424.8.1) (:span 95 252)))\n (:identifiers (:sid . :s424.8) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003896@unknown@formal@none@1@S@This indicates that functional differences observed in IL-2- and IL-12-stimulated cells may depend, at least in part, on differential gene regulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2-") (:form . "IL-2-") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "il-12-stimulated") (:form . "IL-12-stimulated")\n  (:end . 81) (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 98)\n  (:start . 92) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 133)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x424.9.1) (:span 88 91)) ((:id . :x424.9.2) (:span 5 19)))\n (:hscopes ((:id . :x424.9.1) (:span 88 149))\n  ((:id . :x424.9.2) (:span 5 149)))\n (:identifiers (:sid . :s424.9) (:did . :|97025427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003897@unknown@formal@none@1@S@A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sp1-") (:form . "Sp1-") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "Ets-related") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "ctl-specific") (:form . "CTL-specific") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "perforin") (:form . "perforin") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s425.1) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003898@unknown@formal@none@1@S@This study was designed to determine the potential cis-elements involved in transcriptional regulation of the mouse perforin gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 91) (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 102)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "perforin") (:form . "perforin") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s425.2) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003900@unknown@formal@none@1@S@The six 5' upstream and one intronic DHS were detected in only perforin-expressing lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 19)\n  (:start . 11) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intronic") (:form . "intronic") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "dhs") (:form . "DHS") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "perforin-expressing")\n  (:form . "perforin-expressing") (:end . 82) (:start . 63) (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s425.4) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003901@unknown@formal@none@1@S@Chloramphenicol acetyltransferase (CAT) activities directed by 5' upstream promoter were detected preferentially in perforin-expressing cell lines.@(((:tag . "NNP") (:stem . "Chloramphenicol") (:form . "Chloramphenicol")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 33) (:start . 16) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 112) (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "perforin-expressing")\n  (:form . "perforin-expressing") (:end . 135) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 146)\n  (:start . 141) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s425.5) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003902@unknown@formal@none@1@S@A construct termed PFP5a containing -795 bp exhibited the highest CAT activity, and PFP9a20 containing only -73 bp also produced significantly high CAT activity in CTLL-R8 cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PFP5a") (:form . "PFP5a") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "CD") (:stem . "-795") (:form . "-795") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PFP9a20") (:form . "PFP9a20") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-73") (:form . "-73") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 142) (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ctll-r8") (:form . "CTLL-R8") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s425.6) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003903@unknown@formal@none@1@S@The proximal region in PFP9a20 contained two potential Sp1 binding sites (GC box and GT box) and one Ets binding site (EBS).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PFP9a20") (:form . "PFP9a20") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gt") (:form . "GT") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EBS") (:form . "EBS") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s425.7) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003904@unknown@formal@none@1@S@Electrophoretic mobility shift assay showed that each of the cis-elements bound specific protein factors.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 43) (:start . 37)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s425.8) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003905@unknown@formal@none@1@S@When single-point mutation was introduced to each GC box, EBS, and GT box in PFP9a20, at least 3-fold less CAT activity was observed in CTLL-R8 cells.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "single-point") (:form . "single-point") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EBS") (:form . "EBS") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GT") (:form . "GT") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PFP9a20") (:form . "PFP9a20") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 88) (:start . 86)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 94) (:start . 89)\n  (:id . 61))\n ((:tag . "RB") (:stem . "3-fold") (:form . "3-fold") (:end . 101)\n  (:start . 95) (:id . 62))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 106) (:start . 102)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 132)\n  (:start . 124) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ctll-r8") (:form . "CTLL-R8") (:end . 143)\n  (:start . 136) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s425.9) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003906@unknown@formal@none@1@S@To confirm the importance of the three cis-acting elements in the perforin gene expression, point mutation was introduced again to each proximal GC box, EBS, and GT box of PFP5a.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "perforin") (:form . "perforin") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "EBS") (:form . "EBS") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GT") (:form . "GT") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 168) (:start . 165)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "PFP5a") (:form . "PFP5a") (:end . 177)\n  (:start . 172) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s425.10) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003907@unknown@formal@none@1@S@The point mutations resulted in a 2.5- to 3-fold reduction of CAT activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2.5-") (:form . "2.5-") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "3-fold") (:form . "3-fold") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s425.11) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003908@unknown@formal@none@1@S@The results suggest that a combination of the three proximal cis-acting elements may constitute a minimal region responsible for CTL-specific expression of perforin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VB") (:stem . "constitute") (:form . "constitute") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ctl-specific") (:form . "CTL-specific") (:end . 141)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "perforin") (:form . "perforin") (:end . 164)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x425.12.1) (:span 81 84))\n  ((:id . :x425.12.2) (:span 12 19)))\n (:hscopes ((:id . :x425.12.1) (:span 81 164))\n  ((:id . :x425.12.2) (:span 12 164)))\n (:identifiers (:sid . :s425.12) (:did . :|97025459|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003910@unknown@formal@none@1@S@Coordination of the immune response to injury or disease in the brain is postulated to involve bi-directional discourse between the immune system and the central nervous system.@(((:tag . "NN") (:stem . "coordination") (:form . "Coordination") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "postulate") (:form . "postulated") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "bi-directional") (:form . "bi-directional")\n  (:end . 109) (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "discourse") (:form . "discourse") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 176)\n  (:start . 170) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s426.2) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003911@unknown@formal@none@1@S@This cross communication involves soluble mediators, including various growth factors, cytokines, and neuropeptides.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cross") (:form . "cross") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "communication") (:form . "communication")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "neuropeptide") (:form . "neuropeptides")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s426.3) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003912@unknown@formal@none@1@S@In this report, we demonstrate that the supernatant from activated T-lymphocytes is able to induce the transcription of a potent cytokine, TGF-beta 2 in glial cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "supernatant") (:form . "supernatant") (:end . 51)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s426.4) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003913@unknown@formal@none@1@S@The activating stimulus invokes signaling mechanisms distinct from known kinase or protease pathways.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "invoke") (:form . "invokes") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s426.5) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003914@unknown@formal@none@1@S@Activation of TGF-beta 2 transcription correlates with the loss of binding activity for an 80 kDA glial labile repressor protein, GLRP, to a responsive region within the TFG-beta 2 promoter.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kda") (:form . "kDA") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "labile") (:form . "labile") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GLRP") (:form . "GLRP") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 151)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 165)\n  (:start . 159) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TFG-beta") (:form . "TFG-beta") (:end . 178)\n  (:start . 170) (:id . 71))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 189)\n  (:start . 181) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s426.6) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003915@unknown@formal@none@1@S@Although GLRP shares some characteristics with the inducible transcription factor AP-1, it appears to be distinct from known AP-1 family members.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "GLRP") (:form . "GLRP") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "share") (:form . "shares") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x426.7.1) (:span 91 98)))\n (:hscopes ((:id . :x426.7.1) (:span 88 144)))\n (:identifiers (:sid . :s426.7) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003916@unknown@formal@none@1@S@These data along with previous observations demonstrating the potent immunosuppressive activity of TGF-beta 2, support a model for a feedback mechanism between the activated T-lymphocytes and astrocytes via TGF-beta 2 to regulate the immune response.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 57)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 86) (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 107)\n  (:start . 99) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "feedback") (:form . "feedback") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 151)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 173)\n  (:start . 164) (:id . 66))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 187) (:start . 174) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 202)\n  (:start . 192) (:id . 69))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 206) (:start . 203)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 215)\n  (:start . 207) (:id . 71))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 217) (:start . 216)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 220) (:start . 218)\n  (:id . 73))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 229)\n  (:start . 221) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 233) (:start . 230)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 240)\n  (:start . 234) (:id . 76))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 249)\n  (:start . 241) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s426.8) (:did . :|97026428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003917@unknown@formal@none@1@S@Dual action of retinoic acid on human embryonic/fetal hematopoiesis: blockade of primitive progenitor proliferation and shift from multipotent/erythroid/monocytic to granulocytic differentiation program.@(((:tag . "JJ") (:stem . "dual") (:form . "Dual") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "embryonic/fetal") (:form . "embryonic/fetal")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 67) (:start . 54) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 115) (:start . 102) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 125)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "multipotent/erythroid/monocytic")\n  (:form . "multipotent/erythroid/monocytic") (:end . 162) (:start . 131)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 178)\n  (:start . 166) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 194) (:start . 179) (:id . 63))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 202)\n  (:start . 195) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s427.1) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003918@unknown@formal@none@1@S@In preliminary studies, we have analyzed the hematopoietic growth factor (HGF) requirement of hematopoietic progenitor cells (HPCs) purified from embryonic-fetal liver (FL) and grown in fetal calf serum-supplemented (FCS+) clonogenic culture.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HGF") (:form . "HGF") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPCs") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "embryonic-fetal") (:form . "embryonic-fetal")\n  (:end . 161) (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "FL") (:form . "FL") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "grow") (:form . "grown") (:end . 182)\n  (:start . 177) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . "NN") (:stem . "calf") (:form . "calf") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "serum-supplemented") (:form . "serum-supplemented")\n  (:end . 215) (:start . 197) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 217) (:start . 216)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "fcs+") (:form . "FCS+") (:end . 221) (:start . 217)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "clonogenic") (:form . "clonogenic") (:end . 233)\n  (:start . 223) (:id . 80))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 241)\n  (:start . 234) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s427.2) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003920@unknown@formal@none@1@S@Furthermore, in the absence of exogenous HGFs, FL monocytic progenitors (colony-forming unit monocyte [CFU-M]) generate large colonies exclusively composed of monocytes-macrophages;@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "hgf") (:form . "HGFs") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FL") (:form . "FL") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "colony-forming") (:form . "colony-forming")\n  (:end . 87) (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CFU-M") (:form . "CFU-M") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "generate") (:form . "generate") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 146)\n  (:start . 135) (:id . 65))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "monocytes-macrophage")\n  (:form . "monocytes-macrophages") (:end . 180) (:start . 159) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 181) (:start . 180)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s427.4) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003921@unknown@formal@none@1@S@these colonies are absent in FCS- clonogenic culture.@(((:tag . "DT") (:stem . "these") (:form . "these") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fcs-") (:form . "FCS-") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "clonogenic") (:form . "clonogenic") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s427.5) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003922@unknown@formal@none@1@S@On this basis, we have investigated the role of all-trans retinoic acid (ATRA) and its isomer 9-cis RA in FL hematopoiesis.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "isomer") (:form . "isomer") (:end . 93)\n  (:start . 87) (:id . 60))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 99) (:start . 94)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "FL") (:form . "FL") (:end . 108) (:start . 106)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 122) (:start . 109) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s427.6) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003923@unknown@formal@none@1@S@Both compounds modulate the growth of purified FL HPCs, which show a dose-dependent shift from mixed/erythroid/ monocytic to granulocytic colony formation.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "FL") (:form . "FL") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPCs") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 83) (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mixed/erythroid/") (:form . "mixed/erythroid/")\n  (:end . 111) (:start . 95) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 137)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 154)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s427.7) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003924@unknown@formal@none@1@S@Studies on unicellular and paired daughter cell culture unequivocally indicate that the shift is mediated by modulation of the HPC differentiation program to the granulopoietic pathway (rather than RA-induced down-modulation of multipotent/erythroid/monocytic HPC growth coupled with recruitment of granulocytic HPCs).@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unicellular") (:form . "unicellular") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "daughter") (:form . "daughter") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "RB") (:stem . "unequivocally") (:form . "unequivocally")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 146) (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "granulopoietic") (:form . "granulopoietic")\n  (:end . 176) (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 184)\n  (:start . 177) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 68))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 192)\n  (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 197) (:start . 193)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "ra-induced") (:form . "RA-induced") (:end . 208)\n  (:start . 198) (:id . 71))\n ((:tag . "NN") (:stem . "down-modulation") (:form . "down-modulation")\n  (:end . 224) (:start . 209) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "multipotent/erythroid/monocytic")\n  (:form . "multipotent/erythroid/monocytic") (:end . 259) (:start . 228)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 263) (:start . 260)\n  (:id . 75))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 270)\n  (:start . 264) (:id . 76))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 278)\n  (:start . 271) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 283) (:start . 279)\n  (:id . 78))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 295)\n  (:start . 284) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 298) (:start . 296)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 311)\n  (:start . 299) (:id . 81))\n ((:tag . "NNS") (:stem . "hpc") (:form . "HPCs") (:end . 316) (:start . 312)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 317) (:start . 316)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 318) (:start . 317)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x427.8.2) (:span 70 83)))\n (:ncues ((:id . :x427.8.1) (:span 186 197)))\n (:hscopes ((:id . :x427.8.2) (:span 70 316)))\n (:nscopes ((:id . :x427.8.1) (:span 186 316)))\n (:identifiers (:sid . :s427.8) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003925@unknown@formal@none@1@S@ATRA and 9-cis RA also exert their effect on the proliferation of primitive HPCs (high-proliferative potential colony-forming cells [HPP-CFCs]) and putative hematopoietic stem cells (HSCs; assayed in Dexter-type long-term culture).@(((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "9-cis") (:form . "9-cis") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 34)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 62) (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "hpc") (:form . "HPCs") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high-proliferative") (:form . "high-proliferative")\n  (:end . 100) (:start . 82) (:id . 57))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "colony-forming") (:form . "colony-forming")\n  (:end . 125) (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HPP-CFC") (:form . "HPP-CFCs") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 170) (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HSC") (:form . "HSCs") (:end . 187) (:start . 183)\n  (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 196)\n  (:start . 189) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "dexter-type") (:form . "Dexter-type") (:end . 211)\n  (:start . 200) (:id . 75))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 221)\n  (:start . 212) (:id . 76))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 229)\n  (:start . 222) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 230) (:start . 229)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x427.9.1) (:span 148 156)))\n (:hscopes ((:id . :x427.9.1) (:span 148 187)))\n (:identifiers (:sid . :s427.9) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003926@unknown@formal@none@1@S@High concentrations of either compound (1) drastically reduced the number of primary HPP-CFC colonies and totally abolished their recloning capacity and (2) inhibited HSC proliferation.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "drastically") (:form . "drastically") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NNP") (:stem . "HPP-CFC") (:form . "HPP-CFC") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "VBG") (:stem . "reclone") (:form . "recloning") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . "NNP") (:stem . "HSC") (:form . "HSC") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 184) (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s427.10) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003927@unknown@formal@none@1@S@It is crucial that these results mirror recent observations indicating that murine adult HPCs transduced with dominant negative ATRA receptor (RAR) gene are immortalized and show a selective blockade of granulocytic differentiation.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "mirror") (:form . "mirror") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "hpc") (:form . "HPCs") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 132) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "immortalize") (:form . "immortalized") (:end . 169)\n  (:start . 157) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 190)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 199)\n  (:start . 191) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 215)\n  (:start . 203) (:id . 74))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 231) (:start . 216) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x427.11.1) (:span 60 75)))\n (:hscopes ((:id . :x427.11.1) (:span 60 231)))\n (:identifiers (:sid . :s427.11) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003928@unknown@formal@none@1@S@Altogether, these results suggest that ATRA/9-cis RA may play a key role in FL hematopoiesis via a dual effect hypothetically mediated by interaction with the RAR/RXR heterodimer, ie, inhibition of HSC/ primitive HPC proliferation and induction of CFU-GEMM/ BFU-E/CFU-M shift from the multipotent/erythroid/monocytic to the granulocytic-neutrophilic differentiation program.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . 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(:end . 374) (:start . 373)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x427.12.1) (:span 111 125))\n  ((:id . :x427.12.2) (:span 53 56)) ((:id . :x427.12.3) (:span 26 33)))\n (:hscopes ((:id . :x427.12.1) (:span 111 178))\n  ((:id . :x427.12.2) (:span 53 373)) ((:id . :x427.12.3) (:span 26 373)))\n (:identifiers (:sid . :s427.12) (:did . :|97028169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003930@unknown@formal@none@1@S@Retinoic acid (RA) and 1,25 alpha-dihydroxycholecalciferol (VitD3) are potent regulators of hematopoletic differentiation.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1,25") (:form . "1,25") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha-dihydroxycholecalciferol")\n  (:form . "alpha-dihydroxycholecalciferol") (:end . 58) (:start . 28)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hematopoletic") (:form . "hematopoletic")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 121) (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s428.2) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003931@unknown@formal@none@1@S@Yet , little is known as to how the RA and VitD3 receptor network operates in hematopoietic cells, and whether receptor interactions can explain the interplay between the RA- and VitD3-signaling pathways during differentiation.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 38) (:start . 36)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 48) (:start . 43)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 57)\n  (:start . 49) (:id . 54))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 65)\n  (:start . 58) (:id . 55))\n ((:tag . "VBZ") (:stem . "operate") (:form . "operates") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 91) (:start . 78) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 132)\n  (:start . 120) (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 144)\n  (:start . 137) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ra-") (:form . "RA-") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "vitd3-signaling") (:form . "VitD3-signaling")\n  (:end . 194) (:start . 179) (:id . 73))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 203)\n  (:start . 195) (:id . 74))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 210)\n  (:start . 204) (:id . 75))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 226) (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x428.3.1) (:span 103 110)))\n (:hscopes ((:id . :x428.3.1) (:span 103 226)))\n (:identifiers (:sid . :s428.3) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003932@unknown@formal@none@1@S@Therefore, we analyzed the expression, DNA binding, and transcriptional activity of the endogenous RA and VitD3 receptors [retinoic acid receptors (RARs), retinoid X receptors (RXRs), and VitD3 receptor (VDR)] in the U-937 cell line, in which RA and VitD3 induce distinct monocytic differentiation pathways.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 71) (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "RA") (:form . 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")") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "retinoid") (:form . "retinoid") (:end . 163)\n  (:start . 155) (:id . 70))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 175)\n  (:start . 166) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "RXR") (:form . "RXRs") (:end . 181) (:start . 177)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 77))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 193)\n  (:start . 188) (:id . 78))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 202)\n  (:start . 194) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 204) (:start . 203)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 207) (:start . 204)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 209) (:start . 208)\n  (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 85))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 222)\n  (:start . 217) (:id . 86))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 227) (:start . 223)\n  (:id . 87))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 232) (:start . 228)\n  (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 233) (:start . 232)\n  (:id . 89))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 90))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 242)\n  (:start . 237) (:id . 91))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 245) (:start . 243)\n  (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 249) (:start . 246)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 255)\n  (:start . 250) (:id . 94))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 262)\n  (:start . 256) (:id . 95))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 271)\n  (:start . 263) (:id . 96))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 281)\n  (:start . 272) (:id . 97))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 297) (:start . 282) (:id . 98))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 306)\n  (:start . 298) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s428.4) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003933@unknown@formal@none@1@S@VitD3 induction resulted in the formation of VDR/RXR DNA-binding complexes on both VitD3 response elements and RA response elements (RAREs).@(((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "VDR/RXR") (:form . "VDR/RXR") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RARE") (:form . "RAREs") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s428.5) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003934@unknown@formal@none@1@S@However, transcriptional activation was only observed from a VitD3 response element-driven reporter construct.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "element-driven") (:form . "element-driven")\n  (:end . 90) (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s428.6) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003935@unknown@formal@none@1@S@Several DNA-binding complexes were detected on RAREs in undifferentiated cells.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "rare") (:form . "RAREs") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "undifferentiated") (:form . "undifferentiated")\n  (:end . 72) (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s428.7) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003936@unknown@formal@none@1@S@Stimulation by RA resulted in increased RAR beta/RXR DNA binding, activated RARE-dependent transcription, and increased expression of RAR-beta.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "beta/RXR") (:form . "beta/RXR") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "rare-dependent") (:form . "RARE-dependent")\n  (:end . 90) (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RAR-beta") (:form . "RAR-beta") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s428.8) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003937@unknown@formal@none@1@S@Concomitant stimulation by VitD3 inhibited the RA-stimulated formation of RAR beta/RXR heterodimers, favoring VDR/RXR binding to the RARE.@(((:tag . "JJ") (:stem . "concomitant") (:form . "Concomitant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ra-stimulated") (:form . "RA-stimulated")\n  (:end . 60) (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "beta/RXR") (:form . "beta/RXR") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 99)\n  (:start . 87) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "favor") (:form . "favoring") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "vdr/rxr") (:form . "VDR/RXR") (:end . 117)\n  (:start . 110) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rare") (:form . "RARE") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s428.9) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003938@unknown@formal@none@1@S@Also, VitD3 inhibited the expression of CD23 and CD49f, characteristic markers of retinoid-induced U-937 cell differentiation.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD49f") (:form . "CD49f") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 70) (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "retinoid-induced") (:form . "retinoid-induced")\n  (:end . 98) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 125) (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s428.10) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003940@unknown@formal@none@1@S@These results demonstrate a complex role for VitD3 in modifying the retinoid differentiation pathway and may have implications for differentiation-inducing therapy of hematopoietic tumors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "modify") (:form . "modifying") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 92) (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 126)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "differentiation-inducing")\n  (:form . "differentiation-inducing") (:end . 155) (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 163)\n  (:start . 156) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 180) (:start . 167) (:id . 64))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 187)\n  (:start . 181) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x428.12.1) (:span 105 108)))\n (:hscopes ((:id . :x428.12.1) (:span 105 187)))\n (:identifiers (:sid . :s428.12) (:did . :|97031178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003941@unknown@formal@none@1@S@Regulation of interferon-gamma gene expression.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 30) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s429.1) (:did . :|97031819|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003942@unknown@formal@none@1@S@Interferon-gamma (IFN-gamma), also known as type II interferon, is an important immunoregulatory gene that has multiple effects on the development, maturation, and function of the immune system.@(((:tag . "NNP") (:stem . "Interferon-gamma") (:form . "Interferon-gamma")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 96) (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 146)\n  (:start . 135) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 158)\n  (:start . 148) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 172)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 186)\n  (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 193)\n  (:start . 187) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s429.2) (:did . :|97031819|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003943@unknown@formal@none@1@S@IFN-gamma mRNA and protein are expressed predominantly by T cells and large granular lymphocytes.@(((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "granular") (:form . "granular") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s429.3) (:did . :|97031819|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003944@unknown@formal@none@1@S@The IFN-gamma mRNA is induced/inhibited in these cell types by a wide variety of extracellular signals, thus implicating a number of diverse, yet convergent signal transduction pathways in its transcriptional control.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induced/inhibite") (:form . "induced/inhibited")\n  (:end . 39) (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 140)\n  (:start . 133) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "convergent") (:form . "convergent") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 163)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 176)\n  (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 185)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 208) (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 216)\n  (:start . 209) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s429.4) (:did . :|97031819|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003945@unknown@formal@none@1@S@In this review, I describe how DNA methylation and specific DNA binding proteins may regulate transcription of the IFN-gamma gene in response to extracellular signals.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "i") (:form . "I") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 46)\n  (:start . 35) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 158) (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 166)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x429.5.1) (:span 81 84)))\n (:hscopes ((:id . :x429.5.1) (:span 81 166)))\n (:identifiers (:sid . :s429.5) (:did . :|97031819|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003946@unknown@formal@none@1@S@Inorganic lead activates NF-kappa B in primary human CD4+ T lymphocytes.@(((:tag . "JJ") (:stem . "inorganic") (:form . "Inorganic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lead") (:form . "lead") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s430.1) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003947@unknown@formal@none@1@S@Inorganic lead (Pb) is a ubiquitous environmental contaminant that produces a variety of effects on humoral and cell mediated immune responses.@(((:tag . "JJ") (:stem . "inorganic") (:form . "Inorganic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lead") (:form . "lead") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Pb") (:form . "Pb") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 35)\n  (:start . 25) (:id . 49))\n ((:tag . "JJ") (:stem . "environmental") (:form . "environmental")\n  (:end . 49) (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "contaminant") (:form . "contaminant") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "humoral") (:form . "humoral") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s430.2) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003948@unknown@formal@none@1@S@The underlying molecular mechanism for Pb 's complex effects on the immune system remain obscure.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Pb") (:form . "Pb") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "JJ") (:stem . "obscure") (:form . "obscure") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s430.3) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003950@unknown@formal@none@1@S@NF-kappa B is critical for T lymphocyte function and is a strong inducer of HIV-LTR activation.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-LTR") (:form . "HIV-LTR") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s430.5) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003951@unknown@formal@none@1@S@We demonstrate that Pb at physiologically relevant concentrations activates NF-kappa B in primary human CD4+ T lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Pb") (:form . "Pb") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 41) (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 122)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s430.6) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003952@unknown@formal@none@1@S@Pb-induced activation of NF-kappa B is blocked by antibodies for p65 and p50 subunits but not cRel, indicating that the p65:p50 heterodimer (NF-kappa B) is involved.@(((:tag . "JJ") (:stem . "pb-induced") (:form . "Pb-induced") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "crel") (:form . "cRel") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "CD") (:stem . "p65:p50") (:form . "p65:p50") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 139)\n  (:start . 128) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x430.7.1) (:span 100 115)))\n (:ncues ((:id . :x430.7.2) (:span 90 93)))\n (:hscopes ((:id . :x430.7.1) (:span 100 164)))\n (:nscopes ((:id . :x430.7.2) (:span 90 98)))\n (:identifiers (:sid . :s430.7) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003953@unknown@formal@none@1@S@Functional activation of gene expression by Pb was confirmed using primary CD4+ T cells transfected with an NF-kappa B dependent reporter gene construct.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Pb") (:form . "Pb") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s430.8) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003954@unknown@formal@none@1@S@Pb did not activate NF-kappa B in 4 different T cell lines, suggesting that lymphoid cell lines may not be reliable surrogates for the study of transcriptional activation in human T cells.@(((:tag . "NNP") (:stem . "Pb") (:form . "Pb") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 70)\n  (:start . 60) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "reliable") (:form . "reliable") (:end . 115)\n  (:start . 107) (:id . 63))\n ((:tag . "NNS") (:stem . "surrogate") (:form . "surrogates") (:end . 126)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 159) (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 181) (:start . 180)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x430.9.2) (:span 96 99)) ((:id . :x430.9.3) (:span 60 70)))\n (:ncues ((:id . :x430.9.1) (:span 100 103)) ((:id . :x430.9.4) (:span 7 10)))\n (:hscopes ((:id . :x430.9.2) (:span 96 187))\n  ((:id . :x430.9.3) (:span 60 187)))\n (:nscopes ((:id . :x430.9.1) (:span 100 187))\n  ((:id . :x430.9.4) (:span 7 58)))\n (:identifiers (:sid . :s430.9) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003955@unknown@formal@none@1@S@These data suggest that NF-kappa B may be an important molecular mediator of Pb-induced immunotoxicity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pb-induced") (:form . "Pb-induced") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "immunotoxicity") (:form . "immunotoxicity")\n  (:end . 102) (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x430.10.1) (:span 35 38))\n  ((:id . :x430.10.2) (:span 11 18)))\n (:hscopes ((:id . :x430.10.1) (:span 35 102))\n  ((:id . :x430.10.2) (:span 11 102)))\n (:identifiers (:sid . :s430.10) (:did . :|97032774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003956@unknown@formal@none@1@S@Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.@(((:tag . "JJ") (:stem . "calcium-dependent") (:form . "Calcium-dependent")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 33) (:start . 18) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 48)\n  (:start . 39) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 63)\n  (:start . 52) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 48))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 77)\n  (:start . 67) (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 87)\n  (:start . 78) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p21ha-ras") (:form . "p21Ha-ras") (:end . 100)\n  (:start . 91) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s431.1) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003957@unknown@formal@none@1@S@The induction of immediate-early (IE) response genes, such as egr-1, c-fos, and c-jun, occurs rapidly after the activation of T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ie") (:form . "IE") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 85) (:start . 80)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 93)\n  (:start . 87) (:id . 61))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 101)\n  (:start . 94) (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 107)\n  (:start . 102) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 139)\n  (:start . 128) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s431.2) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003958@unknown@formal@none@1@S@The process of activation involves calcium mobilization, activation of protein kinase C (PKC), and phosphorylation of tyrosine kinases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 114) (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s431.3) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003960@unknown@formal@none@1@S@The involvement of p21(ras) in the regulation of calcium-dependent signals has been suggested through analysis of its role in the activation of NF-AT.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p21(ras)") (:form . "p21(ras)") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 66) (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x431.5.1) (:span 84 93)))\n (:hscopes ((:id . :x431.5.1) (:span 0 149)))\n (:identifiers (:sid . :s431.5) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003961@unknown@formal@none@1@S@We have investigated the inductions of the IE genes in response to calcium signals in Jurkat cells (in the presence of activated p21(ras)) and their correlated consequences.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "induction") (:form . "inductions") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ie") (:form . "IE") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "NNS") (:stem . "p21(ras))") (:form . "p21(ras))") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 159)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 172)\n  (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s431.6) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003962@unknown@formal@none@1@S@The expression of activated p21(ras) negatively regulated the induction of IE genes by calcium ionophore.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "p21(ras)") (:form . "p21(ras)") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "regulate") (:form . "regulated") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ie") (:form . "IE") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s431.7) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003963@unknown@formal@none@1@S@This inhibition of calcium-activated IE gene induction was reversed by treatment with cyclosporin A, suggesting the involvement of calcineurin in this regulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "calcium-activated") (:form . "calcium-activated")\n  (:end . 36) (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 97)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 142)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 161)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x431.8.1) (:span 101 111)))\n (:hscopes ((:id . :x431.8.1) (:span 101 161)))\n (:identifiers (:sid . :s431.8) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003964@unknown@formal@none@1@S@A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "p21(ras)") (:form . "p21(ras)") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 87) (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 151)\n  (:start . 141) (:id . 64))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "NNS") (:stem . "reduction") (:form . "reductions") (:end . 173)\n  (:start . 163) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 209)\n  (:start . 202) (:id . 72))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 220)\n  (:start . 210) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s431.9) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003965@unknown@formal@none@1@S@These results suggest that p2l(ras) is an essential mediator in generating not only positive but also negative modulatory mechanisms controlling the competence of T cells in response to inductive stimulations.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p2l(ras)") (:form . "p2l(ras)") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "generate") (:form . "generating") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "modulatory") (:form . "modulatory") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "competence") (:form . "competence") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "inductive") (:form . "inductive") (:end . 195)\n  (:start . 186) (:id . 70))\n ((:tag . "NNS") (:stem . "stimulation") (:form . "stimulations") (:end . 208)\n  (:start . 196) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x431.10.1) (:span 14 21)))\n (:hscopes ((:id . :x431.10.1) (:span 14 208)))\n (:identifiers (:sid . :s431.10) (:did . :|97042487|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003966@unknown@formal@none@1@S@CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts.@(((:tag . "JJ") (:stem . "cd14-mediated") (:form . "CD14-mediated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Porphyromonas") (:form . "Porphyromonas")\n  (:end . 45) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "gingivalis") (:form . "gingivalis") (:end . 56)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 75) (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gingival") (:form . "gingival") (:end . 93)\n  (:start . 85) (:id . 51))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 105)\n  (:start . 94) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s432.1) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003967@unknown@formal@none@1@S@Lipopolysaccharide (LPS) induces expression of inflammatory cytokines in monocytes/macrophages via CD14, one of the LPS receptors, which is expressed predominantly in these cells.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 94) (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 98) (:start . 95)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 163) (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s432.2) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003968@unknown@formal@none@1@S@It has been demonstrated that Porphyromonas gingivalis LPS (P-LPS) also is able to induce inflammatory cytokines in human gingival fibroblasts.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Porphyromonas") (:form . "Porphyromonas")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "gingivalis") (:form . "gingivalis") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "P-LPS") (:form . "P-LPS") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 102)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "JJ") (:stem . "gingival") (:form . "gingival") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s432.3) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003970@unknown@formal@none@1@S@In this study, we observed unexpectedly by immunohistochemical, Western blotting (immunoblotting), and Northern ( RNA ) blotting assays that CD14 is expressed at high density in human gingival fibroblasts.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "RB") (:stem . "unexpectedly") (:form . "unexpectedly") (:end . 39)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immunohistochemical")\n  (:form . "immunohistochemical") (:end . 62) (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunoblotting") (:form . "immunoblotting")\n  (:end . 96) (:start . 82) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 174)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 183)\n  (:start . 178) (:id . 73))\n ((:tag . "JJ") (:stem . "gingival") (:form . "gingival") (:end . 192)\n  (:start . 184) (:id . 74))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 204)\n  (:start . 193) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s432.5) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003971@unknown@formal@none@1@S@P-LPS-induced expression of the monocyte chemoattractant protein 1 (MCP-1) gene in the cells was inhibited markedly by treatment with anti-human CD14 antibody and was completely inhibited by herbimycin A, a potent inhibitor of tyrosine kinase.@(((:tag . "JJ") (:stem . "p-lps-induced") (:form . "P-LPS-induced")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 56) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "anti-human") (:form . "anti-human") (:end . 144)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 177)\n  (:start . 167) (:id . 68))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 187)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 201)\n  (:start . 191) (:id . 71))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 203) (:start . 202)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 206) (:start . 205)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 213)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 223)\n  (:start . 214) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 235)\n  (:start . 227) (:id . 78))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 242)\n  (:start . 236) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s432.6) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003972@unknown@formal@none@1@S@The inhibitor also dramatically inhibited monocyte chemotactic activity of and MCP-1 production by the cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s432.7) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003973@unknown@formal@none@1@S@Furthermore, P-LPS-induced expression of the MCP-1 gene in the cells also was blocked by inhibitors of two transcription factors, i.e., curcumin, an inhibitor of AP-1, and pyrolidine dithiocarbamate, an inhibitor of NF-kappaB.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "p-lps-induced") (:form . "P-LPS-induced")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "curcumin") (:form . "curcumin") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "pyrolidine") (:form . "pyrolidine") (:end . 182)\n  (:start . 172) (:id . 73))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 198) (:start . 183) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 202) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 212)\n  (:start . 203) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 225)\n  (:start . 216) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s432.8) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003974@unknown@formal@none@1@S@Both inhibitors inhibited monocyte chemotactic activity in the culture supernatant of P-LPS-treated cells.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "supernatant") (:form . "supernatant") (:end . 82)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "p-lps-treated") (:form . "P-LPS-treated")\n  (:end . 99) (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s432.9) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003975@unknown@formal@none@1@S@Gel shift mobility assay showed stimulation of the AP-1 and NF-kappaB contents in P-LPS-treated cells.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "content") (:form . "contents") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "p-lps-treated") (:form . "P-LPS-treated")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s432.10) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003976@unknown@formal@none@1@S@This study is the first to demonstrate the expression of CD14 in human gingival fibroblasts and to show that the signal-transducing pathway of P-LPS in the cells is mediated by CD14.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "gingival") (:form . "gingival") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "signal-transducing") (:form . "signal-transducing")\n  (:end . 131) (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p-lps") (:form . "P-LPS") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 181) (:start . 177)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s432.11) (:did . :|97045131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003977@unknown@formal@none@1@S@Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosines") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "113") (:form . "113") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "128") (:form . "128") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "CD") (:stem . "145") (:form . "145") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 37)\n  (:start . 31) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "augmentation") (:form . "augmentation") (:end . 75)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s433.1) (:did . :|97047763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003978@unknown@formal@none@1@S@SLP-76 (SH2 domain leukocyte protein of 76 kDa) is a recently identified substrate of the TCR-stimulated protein tyrosine kinases that functions in the signal transduction cascade linking the TCR with IL-2 gene expression.@(((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "SH2") (:form . "SH2") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "76") (:form . "76") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 61)\n  (:start . 53) (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 72)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "tcr-stimulated") (:form . "TCR-stimulated")\n  (:end . 104) (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 171)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 179)\n  (:start . 172) (:id . 69))\n ((:tag . "VBG") (:stem . "link") (:form . "linking") (:end . 187)\n  (:start . 180) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 205) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 210) (:start . 206)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s433.2) (:did . :|97047763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003980@unknown@formal@none@1@S@Two tyrosines (Y113 and Y128) fall within an identical five amino-acid motif and are shown to be phosphorylated upon TCR ligation.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "tyrosine") (:form . "tyrosines") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Y113") (:form . "Y113") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "y128") (:form . "Y128") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "fall") (:form . "fall") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 41)\n  (:start . 35) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 54)\n  (:start . 45) (:id . 52))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "amino-acid") (:form . "amino-acid") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 111) (:start . 97) (:id . 61))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s433.4) (:did . :|97047763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003981@unknown@formal@none@1@S@Although mutation of either Y113 and Y128 has a minimal effect on SLP-76 function, mutation of both residues decreases significantly the ability of SLP-76 to promote T cell activation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "y113") (:form . "Y113") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "y128") (:form . "Y128") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 132) (:start . 119) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 183)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s433.5) (:did . :|97047763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003982@unknown@formal@none@1@S@A third tyrosine within the amino-terminal region (Y145) appears to be the most important for optimal SLP-76 function, as altering it alone to phenylalanine has a potent impact on SLP-76 augmentation of NFAT promoter activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 42) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Y145") (:form . "Y145") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "slp-76") (:form . "SLP-76") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phenylalanine") (:form . "phenylalanine")\n  (:end . 156) (:start . 143) (:id . 68))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 169)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 176)\n  (:start . 170) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 186)\n  (:start . 180) (:id . 74))\n ((:tag . "NN") (:stem . "augmentation") (:form . "augmentation") (:end . 199)\n  (:start . 187) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 207) (:start . 203)\n  (:id . 77))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 216)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 225)\n  (:start . 217) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x433.6.1) (:span 57 64)))\n (:hscopes ((:id . :x433.6.1) (:span 0 117)))\n (:identifiers (:sid . :s433.6) (:did . :|97047763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003983@unknown@formal@none@1@S@The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x434.1.1) (:span 39 42)))\n (:nscopes ((:id . :x434.1.1) (:span 39 64)))\n (:identifiers (:sid . :s434.1) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003984@unknown@formal@none@1@S@The lymphoid src kinase pp56(lck) has been shown to be essential for the induction of different T lymphocyte responses, including CD4-mediated enhancement of Ag-induced T cell activation, early T cell differentiation, induction of IL-2 production, and cytotoxicity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "src") (:form . "src") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "JJ") (:stem . "cd4-mediated") (:form . "CD4-mediated") (:end . 142)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 154)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ag-induced") (:form . "Ag-induced") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 186)\n  (:start . 176) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 195) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 216) (:start . 201) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 217) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 227)\n  (:start . 218) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 77))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 235) (:start . 231)\n  (:id . 78))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 246)\n  (:start . 236) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 251) (:start . 248)\n  (:id . 81))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 264)\n  (:start . 252) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s434.2) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003985@unknown@formal@none@1@S@It is assumed that pp56(lck) acts on these processes by phosphorylating substrates.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "phosphorylate") (:form . "phosphorylating")\n  (:end . 71) (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x434.3.1) (:span 6 13)))\n (:hscopes ((:id . :x434.3.1) (:span 0 82)))\n (:identifiers (:sid . :s434.3) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003986@unknown@formal@none@1@S@However, it has been recently reported that the NH2 regulatory domain is sufficient to mediate CD4 accessory function.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nh2") (:form . "NH2") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s434.4) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003987@unknown@formal@none@1@S@In this report we address the contribution of the regulatory and catalytic domains of pp56(lck) to another function of this enzyme independent of CD4: TCR-induced IL-2 production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "address") (:form . "address") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "tcr-induced") (:form . "TCR-induced") (:end . 162)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s434.5) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003988@unknown@formal@none@1@S@Two pp56(lck) mutants lacking either the entire catalytic domain or the entire NH2 regulatory domain were generated, and their abilities to trigger transactivation of the TCR-regulated nuclear factor of activated T cells (NF-AT) region of the IL-2 promoter were compared.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "nh2") (:form . "NH2") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "ability") (:form . "abilities") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 163) (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "tcr-regulated") (:form . "TCR-regulated")\n  (:end . 184) (:start . 171) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 192)\n  (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 199)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 212)\n  (:start . 203) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 214) (:start . 213)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 222) (:start . 221)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 227)\n  (:start . 222) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 77))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 235)\n  (:start . 229) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 242) (:start . 239)\n  (:id . 80))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 247) (:start . 243)\n  (:id . 81))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 256)\n  (:start . 248) (:id . 82))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 261) (:start . 257)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 270)\n  (:start . 262) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x434.6.1) (:span 30 36 65 67)))\n (:ncues ((:id . :x434.6.3) (:span 22 29)))\n (:hscopes ((:id . :x434.6.1) (:span 30 100)))\n (:nscopes ((:id . :x434.6.3) (:span 22 100)))\n (:identifiers (:sid . :s434.6) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003990@unknown@formal@none@1@S@Moreover, the catalytic domain of pp56(lck) was able to induce IL-2 cytokine production to an extent similar to that of wild-type pp56(lck).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s434.8) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003991@unknown@formal@none@1@S@We conclude that different domains of the pp56(lck) molecule contribute to regulate distinct biologic functions.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s434.9) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003992@unknown@formal@none@1@S@In fact, while the NH2 regulatory domain is sufficient to mediate CD4 accessory function, we show here that the catalytic domain of pp56(lck) is sufficient for induction of IL-2 production, mimicking TCR ligation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nh2") (:form . "NH2") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 33)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 121)\n  (:start . 112) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "pp56(lck)") (:form . "pp56(lck)") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 169)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 177) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 188)\n  (:start . 178) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "mimic") (:form . "mimicking") (:end . 199)\n  (:start . 190) (:id . 75))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 203) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 212)\n  (:start . 204) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s434.10) (:did . :|97047764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003993@unknown@formal@none@1@S@Isolation and characterization of murine fra-1: induction mediated by CD40 and surface Ig is protein kinase C dependent.@(((:tag . "NN") (:stem . "isolation") (:form . "Isolation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 30) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s435.1) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5003994@unknown@formal@none@1@S@The murine fra-1 gene, encoding Fos-related Ag 1, was isolated from a splenic cDNA library and sequenced.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "fos-related") (:form . "Fos-related") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s435.2) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003995@unknown@formal@none@1@S@Murine fra-1 was highly homologous to rat and human fra-1.@(((:tag . "JJ") (:stem . "murine") (:form . "Murine") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s435.3) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003996@unknown@formal@none@1@S@Oligonucleotide primers based on the murine sequence were used to construct a quantitative reverse transcription-PCR assay for gene expression.@(((:tag . "NNP") (:stem . "Oligonucleotide") (:form . "Oligonucleotide")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 29) (:start . 24)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VB") (:stem . "construct") (:form . "construct") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "quantitative") (:form . "quantitative") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "NNP") (:stem . "transcription-PCR") (:form . "transcription-PCR")\n  (:end . 116) (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s435.4) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003997@unknown@formal@none@1@S@B lymphocyte stimulation via both CD40 and surface Ig (sIg) receptors substantially induced fra-1 expression, and for both receptors, induction was protein kinase C (PKC) dependent.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sig") (:form . "sIg") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 143)\n  (:start . 134) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 162)\n  (:start . 156) (:id . 68))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 180)\n  (:start . 171) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s435.5) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5003998@unknown@formal@none@1@S@This contrasts with induction of c-fos by both CD40 and sIg, which is PKC independent and indicates that CD40 is capable of signaling through PKC or a closely related kinase.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contrast") (:form . "contrasts") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sig") (:form . "sIg") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 85)\n  (:start . 74) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 133)\n  (:start . 124) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 69))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 158)\n  (:start . 151) (:id . 70))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 166)\n  (:start . 159) (:id . 71))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 173)\n  (:start . 167) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x435.6.1) (:span 146 148))\n  ((:id . :x435.6.2) (:span 90 104)))\n (:hscopes ((:id . :x435.6.1) (:span 142 173))\n  ((:id . :x435.6.2) (:span 90 173)))\n (:identifiers (:sid . :s435.6) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004000@unknown@formal@none@1@S@CD40-mediated fra-1 induction did require tyrosine kinase activity.@(((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "fra-1") (:form . "fra-1") (:end . 19) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s435.8) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004001@unknown@formal@none@1@S@These results demonstrate that CD40, like sIg, may employ PKC in producing select outcomes, that individual B cell receptors may signal downstream events via both PKC-dependent and PKC-independent pathways, and that multiple signal transduction pathways may be used to activate the expression of closely related genes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "like") (:form . 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"closely") (:end . 303)\n  (:start . 296) (:id . 89))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 311)\n  (:start . 304) (:id . 90))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 317)\n  (:start . 312) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 318) (:start . 317)\n  (:id . 92)))@@@1@51@((:hcues ((:id . :x435.9.1) (:span 254 257))\n  ((:id . :x435.9.2) (:span 125 128)) ((:id . :x435.9.3) (:span 47 50)))\n (:hscopes ((:id . :x435.9.1) (:span 216 317))\n  ((:id . :x435.9.2) (:span 125 205)) ((:id . :x435.9.3) (:span 47 90)))\n (:identifiers (:sid . :s435.9) (:did . :|97047769|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004002@unknown@formal@none@1@S@Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.@(((:tag . "NNP") (:stem . "Apoptosis") (:form . "Apoptosis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-1beta-converting")\n  (:form . "IL-1beta-converting") (:end . 102) (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 136)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "glucocorticoid-") (:form . "glucocorticoid-")\n  (:end . 155) (:start . 140) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 172)\n  (:start . 160) (:id . 63))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 185)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s436.1) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004003@unknown@formal@none@1@S@Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells.@(((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s436.2) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004004@unknown@formal@none@1@S@Restimulation of T cell blasts up-regulates Fas and Fas ligand expression, with subsequent interaction leading to cell death.@(((:tag . "NN") (:stem . "restimulation") (:form . "Restimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "up-regulates") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s436.3) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004005@unknown@formal@none@1@S@Overexpression of Bcl-2 in tumor cells blocks apoptosis induced by many stimuli, but inhibition of Fas-mediated killing has not been consistently observed.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 111)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "killing") (:form . "killing") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 145)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x436.4.1) (:span 124 127)))\n (:nscopes ((:id . :x436.4.1) (:span 85 154)))\n (:identifiers (:sid . :s436.4) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004006@unknown@formal@none@1@S@To examine the behavior of Bcl-2 in normal cells, T cell blasts were transiently transfected with Bcl-2 and related gene products to determine the effect on apoptotic signaling.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "behavior") (:form . "behavior") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 80)\n  (:start . 69) (:id . 56))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 142)\n  (:start . 133) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 153)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s436.5) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004007@unknown@formal@none@1@S@Transient overexpression of Bcl-2 in mouse and human T cell blasts did not block Fas-mediated apoptosis, whereas etoposide- and glucocorticoid-induced cytotoxicity was potently inhibited.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "etoposide-") (:form . "etoposide-") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "glucocorticoid-induced") (:end . 150) (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 163)\n  (:start . 151) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 176)\n  (:start . 168) (:id . 65))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 186)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x436.6.1) (:span 71 74)))\n (:nscopes ((:id . :x436.6.1) (:span 71 103)))\n (:identifiers (:sid . :s436.6) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004008@unknown@formal@none@1@S@Expression of Bcl-xL and adenovirus E1B 19K did not interfere with anti-Fas killing.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Bcl-xL") (:form . "Bcl-xL") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "E1B") (:form . "E1B") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "19k") (:form . "19K") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "interfere") (:form . "interfere") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-fas") (:form . "anti-Fas") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "killing") (:form . "killing") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x436.7.1) (:span 48 51)))\n (:nscopes ((:id . :x436.7.1) (:span 48 83)))\n (:identifiers (:sid . :s436.7) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004010@unknown@formal@none@1@S@These results suggest that peripheral T cells use distinct apoptosis signaling pathways with differential sensitivity to Bcl-2 and interleukin-1beta-converting enzyme family protease inhibitors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 105)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 117)\n  (:start . 106) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "interleukin-1beta-converting")\n  (:form . "interleukin-1beta-converting") (:end . 159) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 166)\n  (:start . 160) (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 173)\n  (:start . 167) (:id . 62))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 182)\n  (:start . 174) (:id . 63))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 193)\n  (:start . 183) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x436.9.1) (:span 14 21)))\n (:hscopes ((:id . :x436.9.1) (:span 14 193)))\n (:identifiers (:sid . :s436.9) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004011@unknown@formal@none@1@S@Since T cells normally express Bcl-2 and Bcl-xL following activation, their inability to block Fas-mediated apoptosis may allow for the elimination of self-reactive cells and the appropriate regulation of immune responses.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "Bcl-xL") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 75)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 107)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "self-reactive") (:form . "self-reactive")\n  (:end . 164) (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 190)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 201)\n  (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 211)\n  (:start . 205) (:id . 72))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 221)\n  (:start . 212) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x436.10.1) (:span 118 121)))\n (:hscopes ((:id . :x436.10.1) (:span 118 221)))\n (:identifiers (:sid . :s436.10) (:did . :|97047773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004012@unknown@formal@none@1@S@Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1.@(((:tag . "JJ") (:stem . "comparative") (:form . "Comparative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 47) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 48))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 83) (:start . 64) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 90)\n  (:start . 84) (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 92) (:start . 91)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 100)\n  (:start . 93) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 106)\n  (:start . 101) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 130)\n  (:start . 124) (:id . 58))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 143)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 149)\n  (:start . 144) (:id . 60))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 158)\n  (:start . 150) (:id . 61))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 163) (:start . 159)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s437.1) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004013@unknown@formal@none@1@S@Nonhuman primates are naturally infected with a B-lymphotropic herpesvirus closely related to Epstein-Barr virus (EBV).@(((:tag . "JJ") (:stem . "nonhuman") (:form . "Nonhuman") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "primate") (:form . "primates") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "b-lymphotropic") (:form . "B-lymphotropic")\n  (:end . 62) (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 74)\n  (:start . 63) (:id . 50))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 106)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 112)\n  (:start . 107) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s437.2) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004014@unknown@formal@none@1@S@These simian EBV share considerable genetic, biologic, and epidemiologic features with human EBV, including virus-induced tumorigenesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "share") (:form . "share") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "epidemiologic") (:form . "epidemiologic")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "virus-induced") (:form . "virus-induced")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "tumorigenesis") (:form . "tumorigenesis")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s437.3) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004015@unknown@formal@none@1@S@However, latent, transformation-associated viral genes demonstrate marked sequence divergence among species despite the conserved functions.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transformation-associated")\n  (:form . "transformation-associated") (:end . 42) (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 66)\n  (:start . 55) (:id . 49))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 93)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 107)\n  (:start . 100) (:id . 54))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 115)\n  (:start . 108) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 129)\n  (:start . 120) (:id . 57))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s437.4) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004016@unknown@formal@none@1@S@We have cloned the latent membrane protein 1 (LMP1) homologs from the simian EBV naturally infecting baboons (cercopithicine herpesvirus 12, herpesvirus papio) and rhesus monkeys (cercopithicine herpesvirus 15) for a comparative study with the human EBV oncogene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 76)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "ebv") (:form . "EBV") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "VBG") (:stem . "infect") (:form . "infecting") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "NNS") (:stem . "baboon") (:form . "baboons") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cercopithicine") (:form . "cercopithicine")\n  (:end . 124) (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 152)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "papio") (:form . "papio") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "rhesus") (:form . "rhesus") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "NNS") (:stem . "monkey") (:form . "monkeys") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cercopithicine") (:form . "cercopithicine")\n  (:end . 194) (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 206)\n  (:start . 195) (:id . 74))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 209) (:start . 207)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 214) (:start . 211)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "comparative") (:form . "comparative") (:end . 228)\n  (:start . 217) (:id . 79))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 234)\n  (:start . 229) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 239) (:start . 235)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 243) (:start . 240)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 249)\n  (:start . 244) (:id . 83))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 253) (:start . 250)\n  (:id . 84))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 262)\n  (:start . 254) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s437.5) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004017@unknown@formal@none@1@S@The transmembrane domains are well conserved, but there is striking sequence divergence of the carboxy-terminal cytoplasmic domain essential for B-cell immortalization and interaction with the tumor necrosis factor receptor signaling pathway.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 111) (:start . 95) (:id . 57))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 123)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 151)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 167) (:start . 152) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 64))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 183)\n  (:start . 172) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 198)\n  (:start . 193) (:id . 68))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 207)\n  (:start . 199) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 214)\n  (:start . 208) (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 223)\n  (:start . 215) (:id . 71))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 233)\n  (:start . 224) (:id . 72))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 241)\n  (:start . 234) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s437.6) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004018@unknown@formal@none@1@S@Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF-(kappa)B activity in human cells, to bind the tumor necrosis factor-associated factor 3 (TRAF3) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1, in human B lymphocytes.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1s") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "retain") (:form . "retain") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . 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"in") (:end . 215) (:start . 213)\n  (:id . 79))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 221)\n  (:start . 216) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 226) (:start . 223)\n  (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 229) (:start . 227)\n  (:id . 83))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 236)\n  (:start . 230) (:id . 84))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 247)\n  (:start . 237) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 250) (:start . 248)\n  (:id . 86))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 256)\n  (:start . 251) (:id . 87))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 265)\n  (:start . 257) (:id . 88))\n ((:tag . "JJ") (:stem . "factor-responsive") (:form . 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5004020@unknown@formal@none@1@S@A PXQXT/S-containing sequence is also present in the cytoplasmic domain of the Hodgkin 's disease marker, CD30, and binds TRAF3 in vitro.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pxqxt/s-containing") (:form . "PXQXT/S-containing")\n  (:end . 20) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Hodgkin") (:form . "Hodgkin") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "traf3") (:form . "TRAF3") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s437.9) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004021@unknown@formal@none@1@S@The last 13 amino acids containing a PXQXT/S sequence are highly conserved in human and simian EBV LMP1 but do not bind TRAF3, suggesting a distinct role for this conserved region of LMP1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PXQXT/S") (:form . "PXQXT/S") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "traf3") (:form . "TRAF3") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 137)\n  (:start . 127) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 148)\n  (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 172)\n  (:start . 163) (:id . 72))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 179)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x437.10.1) (:span 127 137)))\n (:ncues ((:id . :x437.10.2) (:span 111 114)))\n (:hscopes ((:id . :x437.10.1) (:span 127 187)))\n (:nscopes ((:id . :x437.10.2) (:span 111 125)))\n (:identifiers (:sid . :s437.10) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004022@unknown@formal@none@1@S@The conserved TRAF3 binding sites in LMP1 and the CD30 Hodgkin 's disease marker provides further evidence that a TRAF3-mediated signal transduction pathway may be important in malignant transformation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "traf3") (:form . "TRAF3") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Hodgkin") (:form . "Hodgkin") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "traf3-mediated") (:form . "TRAF3-mediated")\n  (:end . 128) (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 148)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 186)\n  (:start . 177) (:id . 69))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 201) (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x437.11.1) (:span 157 160)))\n (:hscopes ((:id . :x437.11.1) (:span 157 201)))\n (:identifiers (:sid . :s437.11) (:did . :|97048062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004023@unknown@formal@none@1@S@Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.@(((:tag . "JJ") (:stem . "rapid") (:form . "Rapid") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shuttling") (:form . "shuttling") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "discrimination") (:form . "discrimination")\n  (:end . 42) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 80) (:start . 63) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s438.1) (:did . :|97048170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004024@unknown@formal@none@1@S@Cells need to distinguish between transient Ca2+ signals that induce events such as muscle contraction, secretion, adhesion and synaptic transmission, and sustained Ca2+ signals that are involved in cell proliferation and differentiation.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "need") (:form . "need") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "distinguish") (:form . "distinguish") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "contraction") (:form . "contraction") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "synaptic") (:form . "synaptic") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 186) (:start . 183)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 203) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 217) (:start . 204) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 237) (:start . 222) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s438.2) (:did . :|97048170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004025@unknown@formal@none@1@S@The latter class of events is blocked in lymphocytes by the immunosuppressive drugs cyclosporin A and FK506, which inhibit calcineurin, a Ca2+-activated serine/threonine phosphatase necessary for the nuclear import of NF-AT transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 77) (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 134)\n  (:start . 123) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ca2+-activated") (:form . "Ca2+-activated")\n  (:end . 152) (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 169) (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 181)\n  (:start . 170) (:id . 67))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 191)\n  (:start . 182) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 207)\n  (:start . 200) (:id . 71))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 214)\n  (:start . 208) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 223)\n  (:start . 218) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 237) (:start . 224) (:id . 75))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 245)\n  (:start . 238) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s438.3) (:did . :|97048170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004026@unknown@formal@none@1@S@Here we report that sustained high concentrations of Ca2+, but not transient pulses, are required to maintain NF-AT transcription factors in the nucleus, where they participate in Ca2+-dependent induction of genes required for lymphocyte activation and proliferation.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 49) (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "pulse") (:form . "pulses") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 176)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "ca2+-dependent") (:form . "Ca2+-dependent")\n  (:end . 194) (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 204)\n  (:start . 195) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 213)\n  (:start . 208) (:id . 75))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 222)\n  (:start . 214) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 226) (:start . 223)\n  (:id . 77))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 237)\n  (:start . 227) (:id . 78))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 248)\n  (:start . 238) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 252) (:start . 249)\n  (:id . 80))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 266) (:start . 253) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x438.4.1) (:span 63 66)))\n (:nscopes ((:id . :x438.4.1) (:span 63 83)))\n (:identifiers (:sid . :s438.4) (:did . :|97048170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004027@unknown@formal@none@1@S@Furthermore, overexpression and constitutive nuclear localization of NF-AT, but not Jun, Fos, NF-kappaB, Oct or Ets family members, renders the interleukin-2 enhancer in Jurkat T lymphocytes resistant to FK506 and cyclosporin A.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 65)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "render") (:form . "renders") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 157) (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 176)\n  (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 190)\n  (:start . 179) (:id . 73))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 200)\n  (:start . 191) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 209)\n  (:start . 204) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 225)\n  (:start . 214) (:id . 78))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 227) (:start . 226)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x438.5.1) (:span 80 83)))\n (:nscopes ((:id . :x438.5.1) (:span 80 115)))\n (:identifiers (:sid . :s438.5) (:did . :|97048170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004028@unknown@formal@none@1@S@Thus a primary effect of these immunosuppressive reagents is to control the subcellular localization of the NF-AT family of transcription factors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 48) (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "reagent") (:form . "reagents") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 100)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 145)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s438.6) (:did . :|97048170|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004030@unknown@formal@none@1@S@potentiation of the induction of retinoid-dependent differentiation markers.@(((:tag . "NN") (:stem . "potentiation") (:form . "potentiation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "retinoid-dependent") (:form . "retinoid-dependent")\n  (:end . 51) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 67) (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 75)\n  (:start . 68) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s439.2) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004031@unknown@formal@none@1@S@Treatment of the acute promyelocytic (APL) cell line NB4 with interferon alpha (IFN(alpha)), as well as IFN(beta) and gamma, results in an increased expression of the transcripts coding for retinoic-acid receptor type alpha (RAR(alpha)) and the leukemia-specific retinoic acid receptor PML-RAR.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . 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5004032@unknown@formal@none@1@S@Transcriptional induction of the RAR(alpha) and PML-RAR mRNAs is rapid and it is parallelled by an increase in the corresponding proteins.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 25)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "RAR(alpha)") (:form . "RAR(alpha)") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pml-rar") (:form . "PML-RAR") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "parallel") (:form . "parallelled") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s439.4) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5004034@unknown@formal@none@1@S@However, IFN(alpha) does not have any effects on the retinoid-dependent regulation of the myeloid surface markers CD11b and CD33.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "IFN(alpha)") (:form . "IFN(alpha)") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "retinoid-dependent") (:form . "retinoid-dependent")\n  (:end . 71) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD33") (:form . "CD33") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x439.6.1) (:span 25 28)))\n (:nscopes ((:id . :x439.6.1) (:span 25 128)))\n (:identifiers (:sid . :s439.6) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004035@unknown@formal@none@1@S@The IFN-dependent increase in RAR(alpha) levels and the enhancing effect of the cytokine on retinoid-dependent granulocytic markers expression may be a characteristic of PML-RAR positive cells, since the phenomena are not observed in HL-60 promyelocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ifn-dependent") (:form . "IFN-dependent")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "RAR(alpha)") (:form . "RAR(alpha)") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancing") (:form . "enhancing") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "retinoid-dependent") (:form . "retinoid-dependent")\n  (:end . 110) (:start . 92) (:id . 56))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 123)\n  (:start . 111) (:id . 57))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 131)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 166) (:start . 152) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PML-RAR") (:form . "PML-RAR") (:end . 177)\n  (:start . 170) (:id . 65))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 186)\n  (:start . 178) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 192)\n  (:start . 187) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 199)\n  (:start . 194) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "phenomenon") (:form . "phenomena") (:end . 213)\n  (:start . 204) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 217) (:start . 214)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 221) (:start . 218)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 230)\n  (:start . 222) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 239)\n  (:start . 234) (:id . 76))\n ((:tag . "NNS") (:stem . "promyelocyte") (:form . "promyelocytes")\n  (:end . 253) (:start . 240) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x439.7.2) (:span 143 146)))\n (:ncues ((:id . :x439.7.1) (:span 218 221)))\n (:hscopes ((:id . :x439.7.2) (:span 143 192)))\n (:nscopes ((:id . :x439.7.1) (:span 200 253)))\n (:identifiers (:sid . :s439.7) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004036@unknown@formal@none@1@S@Interferons as well as retinoids inhibit the growth of NB4 cells, although the 2 classes of compounds do not significantly interact in terms of anti-proliferative activity.@(((:tag . "NNS") (:stem . "interferon") (:form . "Interferons") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 122) (:start . 109) (:id . 62))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "anti-proliferative") (:form . "anti-proliferative")\n  (:end . 162) (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s439.8) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004037@unknown@formal@none@1@S@These results suggest the possible use of combinations between IFNs and retinoic acid in the cyto-differentiating treatment of APL patients.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "ifn") (:form . "IFNs") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cyto-differentiating")\n  (:form . "cyto-differentiating") (:end . 113) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 139)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x439.9.1) (:span 26 34)) ((:id . :x439.9.2) (:span 14 21)))\n (:hscopes ((:id . :x439.9.1) (:span 26 139))\n  ((:id . :x439.9.2) (:span 14 139)))\n (:identifiers (:sid . :s439.9) (:did . :|97050805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004038@unknown@formal@none@1@S@Susceptibility to natural killer cells and down regulation of MHC class I expression in adenovirus 12 transformed cells are regulated by different E1A domains.@(((:tag . "NN") (:stem . "susceptibility") (:form . "Susceptibility")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "down") (:form . "down") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 133)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s440.1) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004040@unknown@formal@none@1@S@In these cells, the expression of MHC-class I antigens is repressed and might allow them to escape from recognition by cytotoxic T lymphocytes (CTL) and to develop in tumor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mhc-class") (:form . "MHC-class") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "repress") (:form . "repressed") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "VB") (:stem . "escape") (:form . "escape") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 142)\n  (:start . 131) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "VB") (:stem . "develop") (:form . "develop") (:end . 163)\n  (:start . 156) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 172)\n  (:start . 167) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x440.3.1) (:span 72 77)))\n (:hscopes ((:id . :x440.3.1) (:span 72 172)))\n (:identifiers (:sid . :s440.3) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004041@unknown@formal@none@1@S@Furthermore, these cell lines appear resistant to lysis by natural killer (NK) cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x440.4.1) (:span 30 36)))\n (:hscopes ((:id . :x440.4.1) (:span 30 84)))\n (:identifiers (:sid . :s440.4) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004042@unknown@formal@none@1@S@To determine the E1A domain ( s ) responsible for these properties several cell lines were created by transforming baby rat kidney (BRK) cells with a set of plasmids expressing different Ad2/Ad12 hybrid E1A gene products.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 45)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 114)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "baby") (:form . "baby") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kidney") (:form . "kidney") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "BRK") (:form . "BRK") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 165)\n  (:start . 157) (:id . 72))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 176)\n  (:start . 166) (:id . 73))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 186)\n  (:start . 177) (:id . 74))\n ((:tag . "NN") (:stem . "ad2/ad12") (:form . "Ad2/Ad12") (:end . 195)\n  (:start . 187) (:id . 75))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 202)\n  (:start . 196) (:id . 76))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 206) (:start . 203)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 211) (:start . 207)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 220)\n  (:start . 212) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s440.5) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004043@unknown@formal@none@1@S@The MHC class 1 gene expression was inhibited in cells expressing the Ad12 13S mRNA product and in cells transformed with Ad2/Ad12 hybrid E1A gene product harboring the C-terminal part of the conserved region (CR) 3 of Ad12.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ad12") (:form . "Ad12") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "13s") (:form . "13S") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ad2/ad12") (:form . "Ad2/Ad12") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . "VBG") (:stem . "harbor") (:form . "harboring") (:end . 164)\n  (:start . 155) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 201)\n  (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 208)\n  (:start . 202) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "CR") (:form . "CR") (:end . 212) (:start . 210)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 78))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 215) (:start . 214)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ad12") (:form . "Ad12") (:end . 223) (:start . 219)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s440.6) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004044@unknown@formal@none@1@S@Susceptibility of these transformed cell lines to NK cells was determined by cytolytic assays.@(((:tag . "NN") (:stem . "susceptibility") (:form . "Susceptibility")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytolytic") (:form . "cytolytic") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s440.7) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004045@unknown@formal@none@1@S@The results obtained suggest that two Ad12 E1A domains are required to induce resistance of the cell lines to NK cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ad12") (:form . "Ad12") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "E1A") (:form . "E1A") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x440.8.1) (:span 21 28)))\n (:hscopes ((:id . :x440.8.1) (:span 21 118)))\n (:identifiers (:sid . :s440.8) (:did . :|97051521|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004046@unknown@formal@none@1@S@An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 147)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s441.1) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004047@unknown@formal@none@1@S@Expression of the human interleukin-2 (IL-2) receptor alpha chain gene is potently upregulated by its own ligand, IL-2.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s441.2) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004048@unknown@formal@none@1@S@In this study, we characterize an essential upstream IL-2 response element that contains both consensus and non-consensus GAS motifs, two putative Ets binding sites (EBS), one of which overlaps the consensus GAS motif, and a GATA motif, which overlaps the non-consensus GAS motif.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "characterize") (:form . "characterize") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-consensus") (:form . "non-consensus")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EBS") (:form . "EBS") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 193)\n  (:start . 185) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 76))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 207)\n  (:start . 198) (:id . 77))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 211) (:start . 208)\n  (:id . 78))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 217)\n  (:start . 212) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 224) (:start . 223)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 229) (:start . 225)\n  (:id . 83))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 235)\n  (:start . 230) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 236) (:start . 235)\n  (:id . 85))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 242)\n  (:start . 237) (:id . 86))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 251)\n  (:start . 243) (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 255) (:start . 252)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "non-consensus") (:form . "non-consensus")\n  (:end . 269) (:start . 256) (:id . 89))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 273) (:start . 270)\n  (:id . 90))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 279)\n  (:start . 274) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 92)))@@@1@51@((:hcues ((:id . :x441.3.1) (:span 138 146)))\n (:hscopes ((:id . :x441.3.1) (:span 138 170)))\n (:identifiers (:sid . :s441.3) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004050@unknown@formal@none@1@S@Multiple factors including Stat5, Elf-1, HMG-I(Y) and GATA family proteins bind to the IL-2 response element and mutation of any one of these binding sites diminishes the activity of this element.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . "VBZ") (:stem . "diminish") (:form . "diminishes") (:end . 166)\n  (:start . 156) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 195)\n  (:start . 188) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s441.5) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004051@unknown@formal@none@1@S@An unidentified Ets family protein binds to the EBS overlapping the consensus GAS motif and appears to negatively regulate the human IL-2R alpha promoter.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ebs") (:form . "EBS") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x441.6.1) (:span 92 99)))\n (:hscopes ((:id . :x441.6.1) (:span 92 153)))\n (:identifiers (:sid . :s441.6) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004052@unknown@formal@none@1@S@Thus, IL-2-induced IL-2R alpha promoter activity requires a complex upstream element, which appears to contain binding sites for both positive and negative regulatory factors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 18)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 166)\n  (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x441.7.1) (:span 92 99)))\n (:hscopes ((:id . :x441.7.1) (:span 86 174)))\n (:identifiers (:sid . :s441.7) (:did . :|97051821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004053@unknown@formal@none@1@S@Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd40-activated") (:form . "CD40-activated")\n  (:end . 78) (:start . 64) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 98)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s442.1) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004054@unknown@formal@none@1@S@In vitro, human B lymphocytes undergo long-term proliferation when activated through CD40, a protein expressed on their cell surface.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s442.2) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004055@unknown@formal@none@1@S@The nature of CD40-dependent signals in proliferating fresh human Epstein-Barr virus-negative B lymphocytes is currently unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd40-dependent") (:form . "CD40-dependent")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "proliferate") (:form . "proliferating") (:end . 53)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 78)\n  (:start . 66) (:id . 51))\n ((:tag . "JJ") (:stem . "virus-negative") (:form . "virus-negative")\n  (:end . 93) (:start . 79) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 107)\n  (:start . 96) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 120)\n  (:start . 111) (:id . 56))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s442.3) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004056@unknown@formal@none@1@S@In this study, a CD40-dependent B cell culture system was used to examine the role of different signal transduction elements.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cd40-dependent") (:form . "CD40-dependent")\n  (:end . 31) (:start . 17) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 95)\n  (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 115)\n  (:start . 103) (:id . 61))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s442.4) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004057@unknown@formal@none@1@S@Protein kinase C (PKC) depletion generated by a long-term phorbol 12 myristate 13-acetate treatment had weak effects on proliferation.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 133) (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s442.5) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004058@unknown@formal@none@1@S@Rather, tyrosine phosphorylation was shown to be directly involved in mediating CD40-dependent signals.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "cd40-dependent") (:form . "CD40-dependent")\n  (:end . 94) (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s442.6) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004060@unknown@formal@none@1@S@In contrast, the cAMP-dependent protein kinase specific inhibitor H-89 totally inhibited HIV-1 LTR activity at a concentration as low as 100 nM without affecting cellular proliferation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 31) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "h-89") (:form . "H-89") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 126) (:start . 113) (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 184) (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x442.8.1) (:span 144 151)))\n (:nscopes ((:id . :x442.8.1) (:span 144 184)))\n (:identifiers (:sid . :s442.8) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004061@unknown@formal@none@1@S@Electrophoretic mobility shift assay (EMSA) and supershift assay using an NF-kappa B binding sequence from the kappa light chain as a probe, revealed that both p65 (RelA) and c-Rel were present in CD40-stimulated B cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 169) (:start . 165)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 180)\n  (:start . 175) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 185) (:start . 181)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 193)\n  (:start . 186) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "cd40-stimulated") (:form . "CD40-stimulated")\n  (:end . 212) (:start . 197) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 214) (:start . 213)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s442.9) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004062@unknown@formal@none@1@S@While PKC depletion did not alter the NF-kappa B level, treatment of B lymphocytes with H-89 or herbimycin A provoked a decrease in the NF-kappa B level.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 82)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "H-89") (:form . "H-89") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "provoke") (:form . "provoked") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x442.10.1) (:span 24 27)))\n (:nscopes ((:id . :x442.10.1) (:span 24 54)))\n (:identifiers (:sid . :s442.10) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004063@unknown@formal@none@1@S@These observations establish the importance of different signal transducing pathways leading to CD40 activation of B lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "transducing") (:form . "transducing") (:end . 75)\n  (:start . 64) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 84)\n  (:start . 76) (:id . 51))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 92)\n  (:start . 85) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 128)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s442.11) (:did . :|97054651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004064@unknown@formal@none@1@S@Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells.@(((:tag . "JJ") (:stem . "active") (:form . "Active") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transactivator-encoding")\n  (:form . "transactivator-encoding") (:end . 58) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "air-1") (:form . "AIR-1") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 126) (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 140)\n  (:start . 135) (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 168)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 175)\n  (:start . 169) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 191) (:start . 176) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 196) (:start . 192)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 198) (:start . 197)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 70))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 214)\n  (:start . 208) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x443.1.1) (:span 94 98)))\n (:nscopes ((:id . :x443.1.1) (:span 94 159)))\n (:identifiers (:sid . :s443.1) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004065@unknown@formal@none@1@S@In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 61) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 167)\n  (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s443.2) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004066@unknown@formal@none@1@S@Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription.@(((:tag . "NNP") (:stem . "Class") (:form . "Class") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "abrogation") (:form . "abrogation") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x443.3.1) (:span 23 26)))\n (:nscopes ((:id . :x443.3.1) (:span 23 52)))\n (:identifiers (:sid . :s443.3) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004067@unknown@formal@none@1@S@We show here that the plasma cell-specific repressor function, designated SIR (suppressor of immune response genes), does not act directly on the transcription of class II genes, but instead on the transcription of the AIR-1 gene, whose product, the class II transactivator (CIITA), is fundamental for the regulation of the constitutive and inducible expression of MHC class II genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . 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"class") (:end . 374)\n  (:start . 369) (:id . 108))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 377) (:start . 375)\n  (:id . 109))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 383)\n  (:start . 378) (:id . 110))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 384) (:start . 383)\n  (:id . 111)))@@@1@70@((:ncues ((:id . :x443.4.1) (:span 122 125)))\n (:nscopes ((:id . :x443.4.1) (:span 122 177)))\n (:identifiers (:sid . :s443.4) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004068@unknown@formal@none@1@S@This was unambiguously demonstrated by the fact that plasmacytoma x B cell hybrids carrying an AIR-1 locus derived from CIITA-expressing cells do not express CIITA-specific transcripts.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "unambiguously") (:form . "unambiguously")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 35)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "air-1") (:form . "AIR-1") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ciita-expressing") (:form . "CIITA-expressing")\n  (:end . 136) (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "JJ") (:stem . "ciita-specific") (:form . "CIITA-specific")\n  (:end . 172) (:start . 158) (:id . 66))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 184)\n  (:start . 173) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x443.5.1) (:span 146 149)))\n (:nscopes ((:id . :x443.5.1) (:span 146 184)))\n (:identifiers (:sid . :s443.5) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004070@unknown@formal@none@1@S@These results confirm and extend the notion of the functional conservation of the AIR-1 gene product across species barriers.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "confirm") (:form . "confirm") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "extend") (:form . "extend") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "air-1") (:form . "AIR-1") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "barrier") (:form . "barriers") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s443.7) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004071@unknown@formal@none@1@S@Interestingly, in CIITA-transfected cell hybrids, cell surface expression of the human HLA-DQ heterodimer was not observed.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ciita-transfected") (:form . "CIITA-transfected")\n  (:end . 35) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x443.8.1) (:span 110 113)))\n (:nscopes ((:id . :x443.8.1) (:span 50 122)))\n (:identifiers (:sid . :s443.8) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004072@unknown@formal@none@1@S@This result was not attributable to lack of HLA-DQ alpha or -DQ beta transcription, because both transcripts were present in the CIITA-transfected hybrids, although at reduced levels.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "-DQ") (:form . "-DQ") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "ciita-transfected") (:form . "CIITA-transfected")\n  (:end . 146) (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x443.9.1) (:span 36 40)) ((:id . :x443.9.2) (:span 16 19)))\n (:nscopes ((:id . :x443.9.1) (:span 36 82))\n  ((:id . :x443.9.2) (:span 16 82)))\n (:identifiers (:sid . :s443.9) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004073@unknown@formal@none@1@S@These findings further support our previous observations on the distinct regulation of expression of the human HLA-DQ class II subset, which may be thus controlled at the posttranscriptional level by a CIITA-independent mechanism.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 56)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 190) (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 201) (:start . 200)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "ciita-independent") (:form . "CIITA-independent")\n  (:end . 219) (:start . 202) (:id . 74))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 229)\n  (:start . 220) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x443.10.1) (:span 141 144)))\n (:hscopes ((:id . :x443.10.1) (:span 141 229)))\n (:identifiers (:sid . :s443.10) (:did . :|97054663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004074@unknown@formal@none@1@S@Chromosome 1 aneusomy with 1p36 under-representation is related to histologic grade, DNA aneuploidy, high c-erb B-2 and loss of bcl-2 expression in ductal breast carcinoma.@(((:tag . "NN") (:stem . "chromosome") (:form . "Chromosome") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "aneusomy") (:form . "aneusomy") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "1p36") (:form . "1p36") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "under-representation")\n  (:form . "under-representation") (:end . 52) (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "histologic") (:form . "histologic") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "grade") (:form . "grade") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "aneuploidy") (:form . "aneuploidy") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-erb") (:form . "c-erb") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "b-2") (:form . "B-2") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ductal") (:form . "ductal") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 161)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s444.1) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004075@unknown@formal@none@1@S@Chromosome 1 abnormalities with loss of 1p36 have been investigated in 95 breast-cancer samples by means of a dual-target fluorescence in-situ hybridization (FISH) technique using the pUC 1.77 and p1-79 probes, specific for the 1q12 and 1p36 regions, respectively.@(((:tag . "NN") (:stem . "chromosome") (:form . "Chromosome") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 26)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "1p36") (:form . "1p36") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "CD") (:stem . "95") (:form . "95") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "breast-cancer") (:form . "breast-cancer")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dual-target") (:form . "dual-target") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 134)\n  (:start . 122) (:id . 61))\n ((:tag . "FW") (:stem . "in-situ") (:form . "in-situ") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 156) (:start . 143) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fish") (:form . "FISH") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 179) (:start . 174)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "NN") (:stem . "puc") (:form . "pUC") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . "CD") (:stem . "1.77") (:form . "1.77") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p1-79") (:form . "p1-79") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 209)\n  (:start . 203) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 219)\n  (:start . 211) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 223) (:start . 220)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 78))\n ((:tag . "NN") (:stem . "1q12") (:form . "1q12") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 80))\n ((:tag . "NN") (:stem . "1p36") (:form . "1p36") (:end . 241) (:start . 237)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 249)\n  (:start . 242) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 250) (:start . 249)\n  (:id . 83))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 263)\n  (:start . 251) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s444.2) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004076@unknown@formal@none@1@S@Abnormalities for one or both probes were detected in 83/95 samples.@(((:tag . "NNS") (:stem . "abnormality") (:form . "Abnormalities") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "83/95") (:form . "83/95") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x444.3.1) (:span 22 24)))\n (:hscopes ((:id . :x444.3.1) (:span 18 29)))\n (:identifiers (:sid . :s444.3) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004077@unknown@formal@none@1@S@Relative 1p36 under-representation was found in 79/95.@(((:tag . "JJ") (:stem . "relative") (:form . "Relative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "1p36") (:form . "1p36") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "under-representation")\n  (:form . "under-representation") (:end . 34) (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 44) (:start . 39)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "CD") (:stem . "79/95") (:form . "79/95") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s444.4) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004078@unknown@formal@none@1@S@The clinical relevance of these alterations was studied by comparing the FISH results with several parameters currently used in breast-cancer pathology.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fish") (:form . "FISH") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "breast-cancer") (:form . "breast-cancer")\n  (:end . 141) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "pathology") (:form . "pathology") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s444.5) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004080@unknown@formal@none@1@S@Lobular or mucinous samples showed few or no alterations, whereas most ductal samples had high chromosome 1 polysomy with under-representation of 1p36.@(((:tag . "JJ") (:stem . "lobular") (:form . "Lobular") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mucinous") (:form . "mucinous") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 34) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ductal") (:form . "ductal") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "polysomy") (:form . "polysomy") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "under-representation")\n  (:form . "under-representation") (:end . 142) (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "1p36") (:form . "1p36") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x444.7.2) (:span 39 41)) ((:id . :x444.7.3) (:span 8 10)))\n (:ncues ((:id . :x444.7.1) (:span 42 44)))\n (:hscopes ((:id . :x444.7.2) (:span 35 56)) ((:id . :x444.7.3) (:span 0 19)))\n (:nscopes ((:id . :x444.7.1) (:span 42 56)))\n (:identifiers (:sid . :s444.7) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004081@unknown@formal@none@1@S@In ductal carcinomas, chromosome 1 alterations increased with histologic grade, DNA aneuploidy, loss of bcl-2 and high c-erb B-2 expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ductal") (:form . "ductal") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "carcinoma") (:form . "carcinomas") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "histologic") (:form . "histologic") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "grade") (:form . "grade") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "aneuploidy") (:form . "aneuploidy") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-erb") (:form . "c-erb") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "b-2") (:form . "B-2") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s444.8) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004082@unknown@formal@none@1@S@These associations were found to be statistically significant.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "association") (:form . "associations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s444.9) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004083@unknown@formal@none@1@S@No correlation between chromosome 1 alterations and nuclear grade, age, size, lymph-node involvement, hormonal receptor presence, proliferation activity or p53 protein expression was detected.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "grade") (:form . "grade") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymph-node") (:form . "lymph-node") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "hormonal") (:form . "hormonal") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 143) (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 182) (:start . 179)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 191)\n  (:start . 183) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x444.10.1) (:span 0 2)))\n (:nscopes ((:id . :x444.10.1) (:span 0 191)))\n (:identifiers (:sid . :s444.10) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004084@unknown@formal@none@1@S@These results indicate the utility of this FISH technique for a better definition of the biological characteristics of ductal carcinomas.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "utility") (:form . "utility") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fish") (:form . "FISH") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 70) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 115) (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ductal") (:form . "ductal") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "carcinoma") (:form . "carcinomas") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s444.11) (:did . :|97056026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004085@unknown@formal@none@1@S@Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.@(((:tag . "NN") (:stem . "silencing") (:form . "Silencing") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "eklf") (:form . "EKLF") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s445.1) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004086@unknown@formal@none@1@S@Globin genes are subject to tissue-specific and developmental stage-specific regulation.@(((:tag . "NNP") (:stem . "Globin") (:form . "Globin") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "subject") (:form . "subject") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 43) (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 61) (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 76) (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s445.2) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004087@unknown@formal@none@1@S@A switch from human fetal (gamma)-to adult (beta)- globin expression occurs within erythroid precursor cells of the adult lineage.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "gamma)-to") (:form . "gamma)-to") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "beta)-") (:form . "beta)-") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s445.3) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004088@unknown@formal@none@1@S@Previously we and others showed by targeted gene disruption that the zinc finger gene, erythroid Kruppel-like factor (EKLF), is required for expression of the beta-globin gene in mice, presumably through interaction with a high-affinity binding site in the proximal promoter.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "kruppel-like") (:form . "Kruppel-like") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 151)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 170)\n  (:start . 159) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 183)\n  (:start . 179) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 74))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 195)\n  (:start . 185) (:id . 75))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 203)\n  (:start . 196) (:id . 76))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 215)\n  (:start . 204) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 222) (:start . 221)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 236) (:start . 223) (:id . 80))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 244)\n  (:start . 237) (:id . 81))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 249) (:start . 245)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 256) (:start . 253)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 265)\n  (:start . 257) (:id . 85))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 274)\n  (:start . 266) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x445.4.1) (:span 185 195)))\n (:hscopes ((:id . :x445.4.1) (:span 185 274)))\n (:identifiers (:sid . :s445.4) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004090@unknown@formal@none@1@S@We find that in the absence of EKLF, while human beta-globin expression is dramatically reduced, gamma-globin transcripts are elevated approximately 5-fold.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 42) (:start . 37)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 60)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 87)\n  (:start . 75) (:id . 56))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 148) (:start . 135) (:id . 63))\n ((:tag . "RB") (:stem . "5-fold") (:form . "5-fold") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s445.6) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004091@unknown@formal@none@1@S@Impaired silencing of gamma-globin expression identifies EKLF as the first transcription factor participating quantitatively in the gamma-globin to beta-globin switch.@(((:tag . "JJ") (:stem . "impaired") (:form . "Impaired") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 56)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "eklf") (:form . "EKLF") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 95)\n  (:start . 89) (:id . 53))\n ((:tag . "VBG") (:stem . "participate") (:form . "participating")\n  (:end . 109) (:start . 96) (:id . 54))\n ((:tag . "RB") (:stem . "quantitatively") (:form . "quantitatively")\n  (:end . 124) (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 144)\n  (:start . 132) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 59))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 159)\n  (:start . 148) (:id . 60))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 166)\n  (:start . 160) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s445.7) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004092@unknown@formal@none@1@S@Our findings are compatible with a competitive model of switching in which EKLF mediates an adult stage-specific interaction between the beta-globin gene promoter and the locus control region that excludes the gamma-globin gene.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 112) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 148)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 191)\n  (:start . 185) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 196) (:start . 192)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "exclude") (:form . "excludes") (:end . 205)\n  (:start . 197) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 222)\n  (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s445.8) (:did . :|97057230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004093@unknown@formal@none@1@S@Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications.@(((:tag . "JJ") (:stem . "modulatory") (:form . "Modulatory") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 37) (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "catecholamine") (:form . "catecholamines")\n  (:end . 56) (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-12") (:form . "interleukin-12")\n  (:end . 80) (:start . 66) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interleukin-10") (:form . "interleukin-10")\n  (:end . 99) (:start . 85) (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 110)\n  (:start . 100) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 111) (:start . 110)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 120)\n  (:start . 112) (:id . 55))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 133)\n  (:start . 121) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s446.1) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004094@unknown@formal@none@1@S@Interleukin-12 (IL-12) is a key inducer of differentiation of uncommitted T helper (TH) cells toward the TH1 phenotype, which regulates cellular immunity, whereas IL-10 inhibits TH1 functions and potentiates TH2-regulated responses (i.e. , humoral immunity).@(((:tag . "NN") (:stem . "interleukin-12") (:form . "Interleukin-12")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 58) (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "uncommitted") (:form . "uncommitted") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TH") (:form . "TH") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "th1") (:form . "TH1") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 118)\n  (:start . 109) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 125)\n  (:start . 120) (:id . 65))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 135)\n  (:start . 126) (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 153)\n  (:start . 145) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 162)\n  (:start . 155) (:id . 70))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 177)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "th1") (:form . "TH1") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 207)\n  (:start . 196) (:id . 76))\n ((:tag . "JJ") (:stem . "th2-regulated") (:form . "TH2-regulated")\n  (:end . 221) (:start . 208) (:id . 77))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 231)\n  (:start . 222) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 79))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 237) (:start . 233)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "humoral") (:form . "humoral") (:end . 247)\n  (:start . 240) (:id . 82))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 256)\n  (:start . 248) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 257) (:start . 256)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s446.2) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004095@unknown@formal@none@1@S@To examine the potential effects of stress on TH1/TH2 balance, we studied the ability of three prototype stress hormones-dexamethasone (a synthetic glucocorticoid) and the catecholamines norepinephrine and epinephrine-to alter the production of IL-12 (p70) and IL-10 induced by bacterial lipopolysaccharide (LPS) in human whole blood.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stress") (:form . 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5004096@unknown@formal@none@1@S@Dexamethasone inhibited LPS-induced bioactive IL-12 production in a dose-dependent fashion and at physiologically relevant concentrations;@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 35)\n  (:start . 24) (:id . 44))\n ((:tag . "JJ") (:stem . "bioactive") (:form . "bioactive") (:end . 45)\n  (:start . 36) (:id . 45))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 51) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 62)\n  (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 82) (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 90)\n  (:start . 83) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 113) (:start . 98) (:id . 54))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 122)\n  (:start . 114) (:id . 55))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 137) (:start . 123) (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 138) (:start . 137)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s446.4) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004097@unknown@formal@none@1@S@it had no effect on IL-10 secretion.@(((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 36) (:start . 35)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x446.5.1) (:span 7 9)))\n (:nscopes ((:id . :x446.5.1) (:span 7 35)))\n (:identifiers (:sid . :s446.5) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004098@unknown@formal@none@1@S@The glucocorticoid-induced reduction of IL-12 production was antagonized by RU 486, a glucocorticoid-receptor antagonist, suggesting that it was mediated by the glucocorticoid receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "glucocorticoid-induced") (:end . 26) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 36)\n  (:start . 27) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 56)\n  (:start . 46) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "antagonize") (:form . "antagonized") (:end . 72)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "glucocorticoid-receptor")\n  (:form . "glucocorticoid-receptor") (:end . 109) (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 132)\n  (:start . 122) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 175) (:start . 161) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 184)\n  (:start . 176) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x446.6.1) (:span 122 132)))\n (:hscopes ((:id . :x446.6.1) (:span 122 184)))\n (:identifiers (:sid . :s446.6) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004100@unknown@formal@none@1@S@both catecholamines, however, dose-dependently increased the production of IL-10.@(((:tag . "DT") (:stem . "both") (:form . "both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "catecholamine") (:form . "catecholamines")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 46) (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s446.8) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004101@unknown@formal@none@1@S@The effects of either catecholamine on IL-12 or IL-10 secretion were blocked completely by propranolol, a beta-adrenoreceptor antagonist, indicating that they were mediated by the beta-adrenergic receptor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "catecholamine") (:form . "catecholamine")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "propranolol") (:form . "propranolol") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta-adrenoreceptor")\n  (:form . "beta-adrenoreceptor") (:end . 125) (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 136)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 163) (:start . 159)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 172)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "beta-adrenergic") (:form . "beta-adrenergic")\n  (:end . 195) (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 204)\n  (:start . 196) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x446.9.1) (:span 138 153)))\n (:hscopes ((:id . :x446.9.1) (:span 138 204)))\n (:identifiers (:sid . :s446.9) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004102@unknown@formal@none@1@S@These findings suggest that the central nervous system may regulate IL-12 and IL-10 secretion and, hence, TH1/TH2 balance via the peripheral end-effectors of the stress system.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "th1/th2") (:form . "TH1/TH2") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 140)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "end-effector") (:form . "end-effectors")\n  (:end . 154) (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 168)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x446.10.1) (:span 55 58))\n  ((:id . :x446.10.2) (:span 15 22)))\n (:hscopes ((:id . :x446.10.1) (:span 55 175))\n  ((:id . :x446.10.2) (:span 15 175)))\n (:identifiers (:sid . :s446.10) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004103@unknown@formal@none@1@S@Thus, stress may cause a selective suppression of TH1 functions and a shift toward a TH2 cytokine pattern rather than generalized TH suppression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "th1") (:form . "TH1") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "th2") (:form . "TH2") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "generalize") (:form . "generalized") (:end . 129)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "th") (:form . "TH") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 144)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x446.11.2) (:span 13 16)))\n (:ncues ((:id . :x446.11.1) (:span 106 117)))\n (:hscopes ((:id . :x446.11.2) (:span 13 144)))\n (:nscopes ((:id . :x446.11.1) (:span 106 144)))\n (:identifiers (:sid . :s446.11) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004104@unknown@formal@none@1@S@The TH1-to-TH2 shift may be responsible for the stress-induced susceptibility of the organism to certain infections.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "th1-to-th2") (:form . "TH1-to-TH2") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "stress-induced") (:form . "stress-induced")\n  (:end . 62) (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 77) (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x446.12.1) (:span 21 24)))\n (:hscopes ((:id . :x446.12.1) (:span 21 115)))\n (:identifiers (:sid . :s446.12) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004105@unknown@formal@none@1@S@Through the same or a reciprocal mechanism, states associated with chronic hyperactivity or hypoactivity of the stress system might influence the susceptibility of an individual to certain autoimmune, allergic, infectious, or neoplastic diseases.@(((:tag . "IN") (:stem . "through") (:form . "Through") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "reciprocal") (:form . "reciprocal") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "hyperactivity") (:form . "hyperactivity")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hypoactivity") (:form . "hypoactivity") (:end . 104)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 141)\n  (:start . 132) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 160) (:start . 146) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "individual") (:form . "individual") (:end . 177)\n  (:start . 167) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 188)\n  (:start . 181) (:id . 69))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 199)\n  (:start . 189) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 209)\n  (:start . 201) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 221)\n  (:start . 211) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 225) (:start . 223)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "neoplastic") (:form . "neoplastic") (:end . 236)\n  (:start . 226) (:id . 77))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 245)\n  (:start . 237) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x446.13.1) (:span 126 131)))\n (:hscopes ((:id . :x446.13.1) (:span 126 245)))\n (:identifiers (:sid . :s446.13) (:did . :|97058563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004106@unknown@formal@none@1@S@Nasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin 's disease.@(((:tag . "JJ") (:stem . "nasal") (:form . "Nasal") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NK-") (:form . "NK-") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nasopharyngeal") (:form . "nasopharyngeal")\n  (:end . 98) (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Hodgkin") (:form . "Hodgkin") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s447.1) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004107@unknown@formal@none@1@S@Nasal T/NK-cell lymphomas can be further separated into those of natural killer (NK) cell lineage or of T-cell lineage, with differences in cellular phenotype, T-cell receptor (TcR) gene rearrangement and TcR transcript expression.@(((:tag . "JJ") (:stem . "nasal") (:form . "Nasal") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T/NK-cell") (:form . "T/NK-cell") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 136)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 175)\n  (:start . 167) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 200) (:start . 187) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 77))\n ((:tag . "NN") (:stem . "tcr") (:form . "TcR") (:end . 208) (:start . 205)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 219)\n  (:start . 209) (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 230)\n  (:start . 220) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s447.2) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004108@unknown@formal@none@1@S@Both NK- and T-cell subtypes are closely associated with Epstein-Barr virus (EBV).@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nk-") (:form . "NK-") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "subtype") (:form . "subtypes") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s447.3) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004110@unknown@formal@none@1@S@Of the 23 cases, 19 were classified as NK-cell and 4 as T-cell tumours.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 19) (:start . 17)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "classify") (:form . "classified") (:end . 35)\n  (:start . 25) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NK-cell") (:form . "NK-cell") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 52) (:start . 51)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 62)\n  (:start . 56) (:id . 55))\n ((:tag . "NNS") (:stem . "tumour") (:form . "tumours") (:end . 70)\n  (:start . 63) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s447.5) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004111@unknown@formal@none@1@S@ISH for EBV-encoded small non-polyadenylated RNAs showed that all cases, whether NK or T, harboured EBV in virtually all tumour cells.@(((:tag . "NN") (:stem . "ish") (:form . "ISH") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "ebv-encoded") (:form . "EBV-encoded") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "non-polyadenylated") (:form . "non-polyadenylated")\n  (:end . 44) (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 56) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "harbour") (:form . "harboured") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x447.6.1) (:span 84 86)) ((:id . :x447.6.2) (:span 73 80)))\n (:hscopes ((:id . :x447.6.1) (:span 81 88))\n  ((:id . :x447.6.2) (:span 73 88)))\n (:identifiers (:sid . :s447.6) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004112@unknown@formal@none@1@S@RT-PCR demonstrated that NL of both subtypes expressed EBNAI of the QUK splice pattern, the latent membrane proteins, LMP1 and 2 and the BamHI A rightward transcripts in the absence of EBNA2 mRNAs, compatible with the latency type II pattern.@(((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NL") (:form . "NL") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "subtype") (:form . "subtypes") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "EBNAI") (:form . "EBNAI") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "QUK") (:form . "QUK") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BamHI") (:form . "BamHI") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 144) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "rightward") (:form . "rightward") (:end . 154)\n  (:start . 145) (:id . 69))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 166)\n  (:start . 155) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 181)\n  (:start . 174) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ebna2") (:form . "EBNA2") (:end . 190)\n  (:start . 185) (:id . 75))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 196)\n  (:start . 191) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 208)\n  (:start . 198) (:id . 78))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 213) (:start . 209)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 80))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 225)\n  (:start . 218) (:id . 81))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 230) (:start . 226)\n  (:id . 82))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 233) (:start . 231)\n  (:id . 83))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 241)\n  (:start . 234) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s447.7) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004113@unknown@formal@none@1@S@In addition, analysis of EBV protein expression by IH revealed a heterogeneous pattern of EBV gene expression at the single-cell level consisting of both LMP1+ and LMP1- tumour cells, suggesting a mixture of latency I and II.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IH") (:form . "IH") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "single-cell") (:form . "single-cell") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "lmp1+") (:form . "LMP1+") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lmp1-") (:form . "LMP1-") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 194)\n  (:start . 184) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "NN") (:stem . "mixture") (:form . "mixture") (:end . 204)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 76))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 215)\n  (:start . 208) (:id . 77))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 217) (:start . 216)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 79))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 224) (:start . 222)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x447.8.1) (:span 184 194)))\n (:hscopes ((:id . :x447.8.1) (:span 184 224)))\n (:identifiers (:sid . :s447.8) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004114@unknown@formal@none@1@S@Although 2 early lytic transcripts, BZLF1 and BHRF1, were also detected in 13 and 10 cases, respectively, the lack of ZEBRA staining in any case indicates that these lytic transcripts are most likely expressed by rare cells in the biopsies entering lytic cycle.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . 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(:end . 261) (:start . 260)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x447.9.1) (:span 193 199))\n  ((:id . :x447.9.2) (:span 145 159)))\n (:ncues ((:id . :x447.9.3) (:span 110 114)))\n (:hscopes ((:id . :x447.9.1) (:span 193 260))\n  ((:id . :x447.9.2) (:span 145 260)))\n (:nscopes ((:id . :x447.9.3) (:span 110 132)))\n (:identifiers (:sid . :s447.9) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004115@unknown@formal@none@1@S@The viral transcriptional pattern similar to that of nasopharyngeal carcinoma and Hodgkin 's disease suggests that EBV can exploit common regulatory mechanisms for gene transcription in diverse host cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nasopharyngeal") (:form . "nasopharyngeal")\n  (:end . 67) (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Hodgkin") (:form . "Hodgkin") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "VB") (:stem . "exploit") (:form . "exploit") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 137)\n  (:start . 131) (:id . 61))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 182) (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 193)\n  (:start . 186) (:id . 68))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 198) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 203) (:start . 199)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 209)\n  (:start . 204) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x447.10.1) (:span 119 122))\n  ((:id . :x447.10.2) (:span 101 109)))\n (:hscopes ((:id . :x447.10.1) (:span 119 209))\n  ((:id . :x447.10.2) (:span 101 209)))\n (:identifiers (:sid . :s447.10) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004116@unknown@formal@none@1@S@Down-regulation of immunogenic proteins (EBNA2-EBNA6) in nasal lymphoma may enable tumour cells to evade host cytotoxic T-cell surveillance.@(((:tag . "NN") (:stem . "down-regulation") (:form . "Down-regulation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immunogenic") (:form . "immunogenic") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EBNA2-EBNA6") (:form . "EBNA2-EBNA6") (:end . 52)\n  (:start . 41) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nasal") (:form . "nasal") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VB") (:stem . "enable") (:form . "enable") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "VB") (:stem . "evade") (:form . "evade") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "surveillance") (:form . "surveillance") (:end . 139)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x447.11.1) (:span 72 75)))\n (:hscopes ((:id . :x447.11.1) (:span 72 139)))\n (:identifiers (:sid . :s447.11) (:did . :|97060432|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004117@unknown@formal@none@1@S@Lack of IL-12 signaling in human allergen-specific Th2 cells.@(((:tag . "NN") (:stem . "lack") (:form . "Lack") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 50) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 51)))@@@1@10@((:ncues ((:id . :x448.1.1) (:span 0 4)))\n (:nscopes ((:id . :x448.1.1) (:span 0 60)))\n (:identifiers (:sid . :s448.1) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004118@unknown@formal@none@1@S@IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells.@(((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "skewer") (:form . "skewer") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "th") (:form . "Th") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s448.2) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004120@unknown@formal@none@1@S@To this aim, allergen-specific CD4+ T cell clones (TCC) were generated from the peripheral blood of three atopic patients, and their cytokine profiles were analyzed.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 30) (:start . 13) (:id . 46))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCC") (:form . "TCC") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 70)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 90)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 132)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 150)\n  (:start . 142) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s448.4) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004121@unknown@formal@none@1@S@The majority of these TCC exhibited a strongly polarized Th2 cytokine profile, and the production of IFN-gamma could not be induced by exogenous IL-12.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCC") (:form . "TCC") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "VBN") (:stem . "polarize") (:form . "polarized") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x448.5.1) (:span 111 120)))\n (:nscopes ((:id . :x448.5.1) (:span 83 150)))\n (:identifiers (:sid . :s448.5) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004122@unknown@formal@none@1@S@Only those TCC with low IFN-gamma levels in the absence of IL-12 responded to IL-12 by additional enhancement of IFN-gamma production.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TCC") (:form . "TCC") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 109)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s448.6) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004123@unknown@formal@none@1@S@The IL-12 nonresponsiveness of the Th2 clones was further evident by the total lack of IL-12-induced phosphorylation of STAT4 (signal transducer and activator of transcription-4), a transcription factor that is typically involved in IL-12 signaling.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nonresponsiveness") (:form . "nonresponsiveness")\n  (:end . 27) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "il-12-induced") (:form . "IL-12-induced")\n  (:end . 100) (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 116) (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 144)\n  (:start . 134) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription-4") (:form . "transcription-4")\n  (:end . 177) (:start . 162) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 195) (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 202)\n  (:start . 196) (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 207) (:start . 203)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 210) (:start . 208)\n  (:id . 74))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 220)\n  (:start . 211) (:id . 75))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 229)\n  (:start . 221) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 77))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 238)\n  (:start . 233) (:id . 78))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 248)\n  (:start . 239) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x448.7.1) (:span 79 83)))\n (:nscopes ((:id . :x448.7.1) (:span 79 178)))\n (:identifiers (:sid . :s448.7) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004124@unknown@formal@none@1@S@Consequently, IL-12 also failed to induce the DNA-binding activity of STAT4-containing complexes in the nuclei of these Th2 clones.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "stat4-containing") (:form . "STAT4-containing")\n  (:end . 86) (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s448.8) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004125@unknown@formal@none@1@S@All TCC expressed equal levels of the low-affinity IL-12R beta1 subunit.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TCC") (:form . "TCC") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "low-affinity") (:form . "low-affinity") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "il-12r") (:form . "IL-12R") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "beta1") (:form . "beta1") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s448.9) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004126@unknown@formal@none@1@S@Our results indicate that human allergen-specific Th cells with strongly polarized Th2 cytokine profiles do not respond to IL-12 and , therefore , can not be induced to produce IFN-gamma.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 49) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "th") (:form . "Th") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "VBN") (:stem . "polarize") (:form . "polarized") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 176)\n  (:start . 169) (:id . 70))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 186)\n  (:start . 177) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x448.10.3) (:span 12 25)))\n (:ncues ((:id . :x448.10.1) (:span 147 154))\n  ((:id . :x448.10.2) (:span 108 111)))\n (:hscopes ((:id . :x448.10.3) (:span 12 186)))\n (:nscopes ((:id . :x448.10.1) (:span 147 186))\n  ((:id . :x448.10.2) (:span 108 128)))\n (:identifiers (:sid . :s448.10) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004127@unknown@formal@none@1@S@The apparent high frequency of IL-12-nonresponsive Th cells within the allergen-specific populations in atopic patients predicts a limited skewing potential of IL-12 in the case of established Th2 responses, but only affecting newly recruited naive Th cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "il-12-nonresponsive")\n  (:form . "IL-12-nonresponsive") (:end . 50) (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 88) (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 100)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 110)\n  (:start . 104) (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 128)\n  (:start . 120) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 138)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "skewing") (:form . "skewing") (:end . 146)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 156)\n  (:start . 147) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 165)\n  (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 65))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "established") (:form . "established") (:end . 192)\n  (:start . 181) (:id . 68))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 196) (:start . 193)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 206)\n  (:start . 197) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 211) (:start . 208)\n  (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 216) (:start . 212)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 226)\n  (:start . 217) (:id . 74))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 232)\n  (:start . 227) (:id . 75))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 242)\n  (:start . 233) (:id . 76))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 248)\n  (:start . 243) (:id . 77))\n ((:tag . "NN") (:stem . "th") (:form . "Th") (:end . 251) (:start . 249)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 257)\n  (:start . 252) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x448.11.1) (:span 4 12)))\n (:hscopes ((:id . :x448.11.1) (:span 4 17)))\n (:identifiers (:sid . :s448.11) (:did . :|97064186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004128@unknown@formal@none@1@S@Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd43/leukosialin-mediated")\n  (:form . "CD43/leukosialin-mediated") (:end . 47) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 55)\n  (:start . 48) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 68)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 78)\n  (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "t-lymphoblastoid") (:form . "T-lymphoblastoid")\n  (:end . 104) (:start . 88) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s449.1) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004130@unknown@formal@none@1@S@NH2-terminal amino acid sequence analysis identified the 140-kDa surface antigen for mAb J393 as CD43/leukosialin, the major sialoglycoprotein of leukocytes.@(((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "140-kda") (:form . "140-kDa") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "j393") (:form . "J393") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD43/leukosialin") (:form . "CD43/leukosialin")\n  (:end . 113) (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "sialoglycoprotein") (:form . "sialoglycoprotein")\n  (:end . 142) (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 156)\n  (:start . 146) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s449.3) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004131@unknown@formal@none@1@S@While Jurkat cells co-expressed two discrete cell-surface isoforms of CD43, recognized by mAb J393 and mAb G10-2, respectively, only J393/CD43 signaled apoptosis.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "co-expresse") (:form . "co-expressed") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "discrete") (:form . "discrete") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "cell-surface") (:form . "cell-surface") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD43") (:form . "CD43") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "j393") (:form . "J393") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "g10-2") (:form . "G10-2") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 126)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "j393/cd43") (:form . "J393/CD43") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . "VBD") (:stem . "signal") (:form . "signaled") (:end . 151)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s449.4) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004132@unknown@formal@none@1@S@J393/CD43 was found to be hyposialylated, bearing predominantly O-linked monosaccharide glycans, whereas G10-2/CD43 bore complex sialylated tetra- and hexasaccharide chains.@(((:tag . "NNP") (:stem . "J393/CD43") (:form . "J393/CD43") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "hyposialylate") (:form . "hyposialylated")\n  (:end . 40) (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "o-linked") (:form . "O-linked") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "monosaccharide") (:form . "monosaccharide")\n  (:end . 87) (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "glycan") (:form . "glycans") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "NNP") (:stem . "G10-2/CD43") (:form . "G10-2/CD43") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "bore") (:form . "bore") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "VBN") (:stem . "sialylate") (:form . "sialylated") (:end . 139)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "tetra-") (:form . "tetra-") (:end . 146)\n  (:start . 140) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hexasaccharide") (:form . "hexasaccharide")\n  (:end . 165) (:start . 151) (:id . 62))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 172)\n  (:start . 166) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s449.5) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004133@unknown@formal@none@1@S@Treatment with soluble, bivalent mAb J393 killed 25-50% of the cell population, while concomitant engagement of either the CD3.TcR complex or the integrins CD18 and CD29 significantly potentiated this effect.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "bivalent") (:form . "bivalent") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "j393") (:form . "J393") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "kill") (:form . "killed") (:end . 48) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "25-50") (:form . "25-50") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cd3.tcr") (:form . "CD3.TcR") (:end . 130)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 155)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "cd18") (:form . "CD18") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cd29") (:form . "CD29") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 183) (:start . 170) (:id . 71))\n ((:tag . "VBD") (:stem . "potentiate") (:form . "potentiated") (:end . 195)\n  (:start . 184) (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 207)\n  (:start . 201) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s449.6) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004134@unknown@formal@none@1@S@Treatment of Jurkat cells with mAb J393 induced tyrosine phosphorylation of specific protein substrates that underwent hyperphosphorylation upon antigen receptor costimulation.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "j393") (:form . "J393") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "undergo") (:form . "underwent") (:end . 118)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "hyperphosphorylation")\n  (:form . "hyperphosphorylation") (:end . 139) (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 144) (:start . 140)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 152)\n  (:start . 145) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 161)\n  (:start . 153) (:id . 61))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 175) (:start . 162) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s449.7) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004135@unknown@formal@none@1@S@Tyrosine kinase inhibition by herbimycin A diminished J393/CD43-mediated apoptosis, whereas inhibition of phosphotyrosine phosphatase activity by bis(maltolato)oxovanadium-IV enhanced cell death.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "j393/cd43-mediated") (:form . "J393/CD43-mediated")\n  (:end . 72) (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 82)\n  (:start . 73) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 102)\n  (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phosphotyrosine") (:form . "phosphotyrosine")\n  (:end . 121) (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 133)\n  (:start . 122) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 142)\n  (:start . 134) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "bis(maltolato)oxovanadium-IV")\n  (:form . "bis(maltolato)oxovanadium-IV") (:end . 174) (:start . 146)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 183)\n  (:start . 175) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 188) (:start . 184)\n  (:id . 61))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 194)\n  (:start . 189) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s449.8) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004136@unknown@formal@none@1@S@Signal transduction through tyrosine kinase activation may lead to altered gene expression, as J393/CD43 ligation prompted decreases in the nuclear localization of the transcriptional regulatory protein NF-kappaB and proteins binding the interferon-inducible regulatory element.@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "j393/cd43") (:form . "J393/CD43") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "VBD") (:stem . "prompt") (:form . "prompted") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 160)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 183) (:start . 168) (:id . 66))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 194)\n  (:start . 184) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 202)\n  (:start . 195) (:id . 68))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 212)\n  (:start . 203) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 225)\n  (:start . 217) (:id . 71))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 233)\n  (:start . 226) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "interferon-inducible")\n  (:form . "interferon-inducible") (:end . 258) (:start . 238) (:id . 74))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 269)\n  (:start . 259) (:id . 75))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 277)\n  (:start . 270) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x449.9.1) (:span 55 58)))\n (:hscopes ((:id . :x449.9.1) (:span 55 90)))\n (:identifiers (:sid . :s449.9) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004137@unknown@formal@none@1@S@Since peripheral blood T-lymphocytes express cryptic epitopes for mAb J393, these findings demonstrate the existence of a tightly regulated CD43-mediated pathway for inducing apoptosis in human T-cell lineages.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 36) (:start . 23) (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "JJ") (:stem . "cryptic") (:form . "cryptic") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "j393") (:form . "J393") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 139)\n  (:start . 130) (:id . 61))\n ((:tag . "JJ") (:stem . "cd43-mediated") (:form . "CD43-mediated")\n  (:end . 153) (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 161)\n  (:start . 154) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 184)\n  (:start . 175) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 193)\n  (:start . 188) (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 200)\n  (:start . 194) (:id . 69))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 209)\n  (:start . 201) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s449.10) (:did . :|97066958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004138@unknown@formal@none@1@S@Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain.@(((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "ligand-induced") (:form . "ligand-induced")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 73) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 81)\n  (:start . 74) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 87) (:start . 82)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-10") (:form . "interleukin-10")\n  (:end . 109) (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 118)\n  (:start . 110) (:id . 55))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 132) (:start . 119) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 139)\n  (:start . 133) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s450.1) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004140@unknown@formal@none@1@S@To define the mechanism underlying signal transducer and activator of transcription (STAT) protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-10 in different cell populations were first defined using electrophoretic mobility shift assays.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 178)\n  (:start . 169) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 200)\n  (:start . 191) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 217)\n  (:start . 206) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 222) (:start . 218)\n  (:id . 77))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 228)\n  (:start . 223) (:id . 78))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 236)\n  (:start . 229) (:id . 79))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 242) (:start . 237)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 258) (:start . 243) (:id . 81))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 267)\n  (:start . 259) (:id . 82))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 273)\n  (:start . 268) (:id . 83))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 280)\n  (:start . 274) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s450.3) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004141@unknown@formal@none@1@S@In all cells tested, IL-10 activated Stat1 and Stat3 and induced the formation of three distinct DNA binding complexes that contained different combinations of these two transcription factors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 19) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NNP") (:stem . "Stat1") (:form . "Stat1") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Stat3") (:form . "Stat3") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 156)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 183) (:start . 170) (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 191)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s450.4) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004142@unknown@formal@none@1@S@IL-10 also activated Stat5 in Ba/F3 cells that stably expressed the murine IL-10 receptor.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "stat5") (:form . "Stat5") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ba/f3") (:form . "Ba/F3") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s450.5) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004143@unknown@formal@none@1@S@Using a structure-function mutagenesis approach, two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for receptor function and for activation of Stat3 but not for Stat1 or Stat5.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "structure-function") (:form . "structure-function")\n  (:end . 26) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 38)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tyr427") (:form . "Tyr427") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tyr477") (:form . "Tyr477") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "RB") (:stem . "redundantly") (:form . "redundantly") (:end . 176)\n  (:start . 165) (:id . 69))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 185)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 207)\n  (:start . 199) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 215) (:start . 212)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 226)\n  (:start . 216) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Stat3") (:form . "Stat3") (:end . 235)\n  (:start . 230) (:id . 78))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 239) (:start . 236)\n  (:id . 79))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 243) (:start . 240)\n  (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 247) (:start . 244)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Stat1") (:form . "Stat1") (:end . 253)\n  (:start . 248) (:id . 82))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 256) (:start . 254)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 262)\n  (:start . 257) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x450.6.1) (:span 240 243)))\n (:nscopes ((:id . :x450.6.1) (:span 240 262)))\n (:identifiers (:sid . :s450.6) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004144@unknown@formal@none@1@S@Twelve amino acid peptides encompassing either of these two tyrosine residues in phosphorylated form coprecipitated Stat3 but not Stat1 and blocked IL-10-induced Stat3 phosphorylation in a cell-free system.@(((:tag . "CD") (:stem . "twelve") (:form . "Twelve") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 95) (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "coprecipitate") (:form . "coprecipitated")\n  (:end . 115) (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 121)\n  (:start . 116) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . "JJ") (:stem . "il-10-induced") (:form . "IL-10-induced")\n  (:end . 161) (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 167)\n  (:start . 162) (:id . 64))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 183) (:start . 168) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 188) (:start . 187)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 198)\n  (:start . 189) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 205)\n  (:start . 199) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x450.7.1) (:span 126 129)))\n (:nscopes ((:id . :x450.7.1) (:span 126 135)))\n (:identifiers (:sid . :s450.7) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004145@unknown@formal@none@1@S@In contrast, tyrosine-phosphorylated peptides containing Tyr374 or Tyr396 did not interact with Stat3 or block Stat3 activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 36) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 56)\n  (:start . 46) (:id . 47))\n ((:tag . "NNP") (:stem . "Tyr374") (:form . "Tyr374") (:end . 63)\n  (:start . 57) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tyr396") (:form . "Tyr396") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x450.8.1) (:span 78 81)))\n (:nscopes ((:id . :x450.8.1) (:span 78 127)))\n (:identifiers (:sid . :s450.8) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004146@unknown@formal@none@1@S@These data demonstrate that Stat3 but not Stat1 or Stat5 is directly recruited to the ligand-activated IL-10 receptor by binding to specific but redundant receptor intracellular domain sequences containing phosphotyrosine.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stat1") (:form . "Stat1") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ligand-activated") (:form . "ligand-activated")\n  (:end . 102) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "redundant") (:form . "redundant") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 177) (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 184)\n  (:start . 178) (:id . 68))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 194)\n  (:start . 185) (:id . 69))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 205)\n  (:start . 195) (:id . 70))\n ((:tag . "NN") (:stem . "phosphotyrosine") (:form . "phosphotyrosine")\n  (:end . 221) (:start . 206) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x450.9.1) (:span 38 41)))\n (:nscopes ((:id . :x450.9.1) (:span 38 56)))\n (:identifiers (:sid . :s450.9) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004147@unknown@formal@none@1@S@This study thus supports the concept that utilization of distinct STAT proteins by different cytokine receptors is dependent on the expression of particular ligand-activatable, tyrosine-containing STAT docking sites in receptor intracellular domains.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "concept") (:form . "concept") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "utilization") (:form . "utilization") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 156)\n  (:start . 146) (:id . 64))\n ((:tag . "JJ") (:stem . "ligand-activatable") (:form . "ligand-activatable")\n  (:end . 175) (:start . 157) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "tyrosine-containing")\n  (:form . "tyrosine-containing") (:end . 196) (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 201) (:start . 197)\n  (:id . 68))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 209)\n  (:start . 202) (:id . 69))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 215)\n  (:start . 210) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 227)\n  (:start . 219) (:id . 72))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 241) (:start . 228) (:id . 73))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 249)\n  (:start . 242) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s450.10) (:did . :|97066996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004148@unknown@formal@none@1@S@Identification and characterization of a leukocyte-specific component of the nuclear body.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 35) (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "leukocyte-specific") (:form . "leukocyte-specific")\n  (:end . 59) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 69)\n  (:start . 60) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s451.1) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004150@unknown@formal@none@1@S@The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NB") (:form . "NB") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 37)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 82)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 98)\n  (:start . 91) (:id . 59))\n ((:tag . "JJ") (:stem . "biliary") (:form . "biliary") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "cirrhosis") (:form . "cirrhosis") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s451.3) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004151@unknown@formal@none@1@S@In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 35)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "JJ") (:stem . "biliary") (:form . "biliary") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "cirrhosis") (:form . "cirrhosis") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 121)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NB") (:form . "NB") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "140-kda") (:form . "140-kDa") (:end . 142)\n  (:start . 135) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 150)\n  (:start . 143) (:id . 70))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 161)\n  (:start . 151) (:id . 71))\n ((:tag . "NNP") (:stem . "Sp140") (:form . "Sp140") (:end . 167)\n  (:start . 162) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s451.4) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004152@unknown@formal@none@1@S@The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 55) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Sp140") (:form . "Sp140") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Sp100") (:form . "Sp100") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NNP") (:stem . "NB") (:form . "NB") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s451.5) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004153@unknown@formal@none@1@S@The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "carboxyl") (:form . "carboxyl") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Sp140") (:form . "Sp140") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "zinc-finger") (:form . "zinc-finger") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bromodomain") (:form . "bromodomain") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 145) (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s451.6) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004154@unknown@formal@none@1@S@High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Sp140") (:form . "Sp140") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x451.7.1) (:span 93 96)))\n (:nscopes ((:id . :x451.7.1) (:span 93 116)))\n (:identifiers (:sid . :s451.7) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004155@unknown@formal@none@1@S@The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SP140") (:form . "SP140") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NB4") (:form . "NB4") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "chemically") (:form . "chemically") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 146) (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s451.8) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004156@unknown@formal@none@1@S@Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells.@(((:tag . "JJ") (:stem . "immunohistochemical")\n  (:form . "Immunohistochemical") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "technique") (:form . "techniques") (:end . 30)\n  (:start . 20) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 55)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sp140") (:form . "SP140") (:end . 66) (:start . 61)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nb") (:form . "NB") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 104) (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s451.9) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004157@unknown@formal@none@1@S@The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sp140") (:form . "Sp140") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NB") (:form . "NB") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 78)\n  (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 86) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 94)\n  (:start . 87) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 103)\n  (:start . 96) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sp140") (:form . "Sp140") (:end . 114)\n  (:start . 109) (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 130)\n  (:start . 122) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 150)\n  (:start . 138) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 159)\n  (:start . 154) (:id . 72))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 173) (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 192)\n  (:start . 187) (:id . 76))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 202)\n  (:start . 193) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x451.10.1) (:span 115 118))\n  ((:id . :x451.10.2) (:span 96 103)))\n (:hscopes ((:id . :x451.10.1) (:span 115 202))\n  ((:id . :x451.10.2) (:span 96 202)))\n (:identifiers (:sid . :s451.10) (:did . :|97067175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004158@unknown@formal@none@1@S@T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice.@(((:tag . "JJ") (:stem . "t-cell-directed") (:form . "T-cell-directed")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TAL-1") (:form . "TAL-1") (:end . 21) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 47)\n  (:start . 41) (:id . 46))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 60)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 74)\n  (:start . 64) (:id . 49))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s452.1) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004160@unknown@formal@none@1@S@In human pathology, the TAL-1 gene product is expressed in a high percentage of T-cell acute lymphoblastic leukemias in the pediatric age range;@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pathology") (:form . "pathology") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tal-1") (:form . "TAL-1") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 106) (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pediatric") (:form . "pediatric") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s452.3) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004161@unknown@formal@none@1@S@however, it has not been established whether the expression has a causal role in oncogenesis.@(((:tag . "RB") (:stem . "however") (:form . "however") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "causal") (:form . "causal") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x452.4.1) (:span 37 44)))\n (:ncues ((:id . :x452.4.2) (:span 16 19)))\n (:hscopes ((:id . :x452.4.1) (:span 37 92)))\n (:nscopes ((:id . :x452.4.2) (:span 9 92)))\n (:identifiers (:sid . :s452.4) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004162@unknown@formal@none@1@S@In this report, we describe the phenotype of mouse transgenic lines obtained by inducing tal-1 protein expression in lymphoid tissues using the LCK promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 139) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lck") (:form . "LCK") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s452.5) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004163@unknown@formal@none@1@S@The survival rate of tal-1 transgenic animals was much lower as compared with control mice.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s452.6) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004164@unknown@formal@none@1@S@Histopathological analysis revealed lymphomas of T-cell type, often comprising a minor B-cell component.@(((:tag . "JJ") (:stem . "histopathological") (:form . "Histopathological")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 35)\n  (:start . 27) (:id . 44))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 45)\n  (:start . 36) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 55)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "comprise") (:form . "comprising") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s452.7) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004165@unknown@formal@none@1@S@Some mice showed marked splenic lymphocyte depletion.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 16) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s452.8) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004166@unknown@formal@none@1@S@Primary lymphocyte cultures showed partial independence from exogenous growth stimuli and increased resistance to low-serum apoptosis.@(((:tag . "JJ") (:stem . "primary") (:form . "Primary") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 34) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "independence") (:form . "independence") (:end . 55)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 77)\n  (:start . 71) (:id . 50))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 85)\n  (:start . 78) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 99)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 110)\n  (:start . 100) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "low-serum") (:form . "low-serum") (:end . 123)\n  (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 133)\n  (:start . 124) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s452.9) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004167@unknown@formal@none@1@S@To further unravel the tal-1 oncogenic potential, a strain of tal-1 transgenic mice was crossbred with p53-/- mice;@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "unravel") (:form . "unravel") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "crossbreed") (:form . "crossbred") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "p53-/-") (:form . "p53-/-") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 114)\n  (:start . 110) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s452.10) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004168@unknown@formal@none@1@S@the survival rate in these animals was reduced by more than one-half when compared with that of tal-1 mice, and histopathological analysis revealed exclusively T-cell lymphomas.@(((:tag . "DT") (:stem . "the") (:form . "the") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "one-half") (:form . "one-half") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 106)\n  (:start . 102) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "histopathological") (:form . "histopathological")\n  (:end . 129) (:start . 112) (:id . 63))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 159)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 166)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 176)\n  (:start . 167) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s452.11) (:did . :|97069862|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004170@unknown@formal@none@1@S@Naive ( CD45RA+ ) T lymphocytes are more sensitive to oxidative stress-induced signals than memory ( CD45RO+ ) cells.@(((:tag . "JJ") (:stem . "naive") (:form . "Naive") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "cd45ra+") (:form . "CD45RA+") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "stress-induced") (:form . "stress-induced")\n  (:end . 78) (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cd45ro+") (:form . "CD45RO+") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s453.1) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004171@unknown@formal@none@1@S@Formation of reactive oxygen intermediates (ROI) after oxidative stress has been shown to be an activation signal for T lymphocytes, e.g., expression of IL-2 and its receptor are induced.@(((:tag . "NN") (:stem . "formation") (:form . "Formation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 131)\n  (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 174)\n  (:start . 166) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 186)\n  (:start . 179) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s453.2) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004172@unknown@formal@none@1@S@These ROI-induced effects can , to a large extent, be attributed to the activation of the transcription factor NF-kappaB.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "roi-induced") (:form . "ROI-induced") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s453.3) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004173@unknown@formal@none@1@S@Now we have examined whether naive and memory T lymphocytes differ in their sensitivity to ROI-mediated signals.@(((:tag . "RB") (:stem . "now") (:form . "Now") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 75)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "roi-mediated") (:form . "ROI-mediated") (:end . 103)\n  (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x453.4.1) (:span 21 28)))\n (:hscopes ((:id . :x453.4.1) (:span 21 111)))\n (:identifiers (:sid . :s453.4) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004174@unknown@formal@none@1@S@When CD45RA+ (naive) and CD45RO+ (memory) T lymphocytes were directly stimulated with H2O2, NF-kappaB nuclear translocation was stronger in naive cells than in memory cells and it could be induced with lower doses.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cd45ra+") (:form . "CD45RA+") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd45ro+") (:form . "CD45RO+") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 40)\n  (:start . 34) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 55)\n  (:start . 44) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 69)\n  (:start . 61) (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 80)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 101)\n  (:start . 92) (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 123) (:start . 110) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 185)\n  (:start . 180) (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 188) (:start . 186)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 196)\n  (:start . 189) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 201) (:start . 197)\n  (:id . 77))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 207) (:start . 202)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 213)\n  (:start . 208) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s453.5) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004175@unknown@formal@none@1@S@The composition of the induced nuclear NF-kappaB (levels of p50 and RelA proteins) was similar in these cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s453.6) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004176@unknown@formal@none@1@S@The magnitude and kinetics of intracellular ROI were similar, suggesting that there were no differences in ROI-forming mechanisms or antioxidative capacities.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "roi-forming") (:form . "ROI-forming") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antioxidative") (:form . "antioxidative")\n  (:end . 146) (:start . 133) (:id . 62))\n ((:tag . "NNS") (:stem . "capacity") (:form . "capacities") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x453.7.2) (:span 62 72)))\n (:ncues ((:id . :x453.7.1) (:span 89 91)))\n (:hscopes ((:id . :x453.7.2) (:span 62 157)))\n (:nscopes ((:id . :x453.7.1) (:span 89 157)))\n (:identifiers (:sid . :s453.7) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004177@unknown@formal@none@1@S@The probable regulatory point was the cytoplasmic IkappaB inhibitor:@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "probable") (:form . "probable") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "ikappab") (:form . "IkappaB") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 68) (:start . 67)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x453.8.1) (:span 4 12)))\n (:hscopes ((:id . :x453.8.1) (:span 4 29)))\n (:identifiers (:sid . :s453.8) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004178@unknown@formal@none@1@S@in CD45RA+ cells, H2O2 caused a more profound depression in the levels of IkappaB alpha.@(((:tag . "IN") (:stem . "in") (:form . "in") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cd45ra+") (:form . "CD45RA+") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "depression") (:form . "depression") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s453.9) (:did . :|97069908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004180@unknown@formal@none@1@S@Potent gene regulatory and antiproliferative activities of 20-methyl analogues of 1,25 dihydroxyvitamin D3.@(((:tag . "JJ") (:stem . "potent") (:form . "Potent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antiproliferative") (:form . "antiproliferative")\n  (:end . 44) (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "20-methyl") (:form . "20-methyl") (:end . 68)\n  (:start . 59) (:id . 49))\n ((:tag . "NNS") (:stem . "analogue") (:form . "analogues") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1,25") (:form . "1,25") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dihydroxyvitamin") (:form . "dihydroxyvitamin")\n  (:end . 103) (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 106) (:start . 104)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s454.1) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004181@unknown@formal@none@1@S@The biological active form of vitamin D3, 1,25-dihydroxyvitamin D3 (VD), regulates cellular growth and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 63) (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 118) (:start . 103) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s454.2) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004182@unknown@formal@none@1@S@This provides the hormone with an interesting therapeutic potential.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s454.3) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004183@unknown@formal@none@1@S@However, hypercalcemia is a side effect, which is caused by VD 's classical action, the regulation of calcium homeostasis.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "hypercalcemia") (:form . "hypercalcemia")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 75)\n  (:start . 66) (:id . 56))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 98)\n  (:start . 88) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 121)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s454.4) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004184@unknown@formal@none@1@S@This made the need for VD analogues with selectively increased cell regulatory properties.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "make") (:form . "made") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "need") (:form . "need") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "vd") (:form . "VD") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "analogue") (:form . "analogues") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s454.5) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004185@unknown@formal@none@1@S@Studies with 20-epi analogues pointed out the importance of the carbon-20 position and led to the development of 20-methyl derivatives of VD.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "20-epi") (:form . "20-epi") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "analogue") (:form . "analogues") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "point") (:form . "pointed") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "carbon-20") (:form . "carbon-20") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "20-methyl") (:form . "20-methyl") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s454.6) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004186@unknown@formal@none@1@S@In this report the biological properties of the compounds ZK161422 and ZK157202, which are 20-methyl- and 20-methyl-23-eneanalogues, respectively, have been analyzed in comparison with VD.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "zk161422") (:form . "ZK161422") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "zk157202") (:form . "ZK157202") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "20-methyl-") (:form . "20-methyl-") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "20-methyl-23-eneanalogue")\n  (:form . "20-methyl-23-eneanalogues") (:end . 131) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 145)\n  (:start . 133) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 156) (:start . 152)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 179)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 187) (:start . 185)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s454.7) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004187@unknown@formal@none@1@S@Both compounds show about 2-fold lower affinity to the VD receptor (VDR) than VD.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "2-fold") (:form . "2-fold") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s454.8) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004188@unknown@formal@none@1@S@However, compared to VD, their antiproliferative effect is up to 30-fold higher on human peripheral blood mononuclear cells and even up to 300-fold higher on human breast cancer MCF-7 cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 30)\n  (:start . 25) (:id . 48))\n ((:tag . "JJ") (:stem . "antiproliferative") (:form . "antiproliferative")\n  (:end . 48) (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "30-fold") (:form . "30-fold") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 79) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 117)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "RB") (:stem . "300-fold") (:form . "300-fold") (:end . 147)\n  (:start . 139) (:id . 66))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 154)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 163)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 177)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "mcf-7") (:form . "MCF-7") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s454.9) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004190@unknown@formal@none@1@S@Moreover, ZK161422, but not ZK157202, showed preference for gene activation from a promoter carrying a VD response element with a palindromic arrangement of two hexameric receptor binding sites spaced by 9 nucleotides (IP9) rather than for activation from a response element formed by a direct repeat spaced by 3 nucleotides (DR3).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "ZK161422") (:form . "ZK161422") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "zk157202") (:form . "ZK157202") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 44) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "preference") (:form . "preference") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "palindromic") (:form . "palindromic") (:end . 141)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "arrangement") (:form . "arrangement") (:end . 153)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "hexameric") (:form . "hexameric") (:end . 170)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 193)\n  (:start . 188) (:id . 72))\n ((:tag . "VBN") (:stem . "space") (:form . "spaced") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 205) (:start . 204)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 217)\n  (:start . 206) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "IP9") (:form . "IP9") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 79))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 230)\n  (:start . 224) (:id . 80))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 235) (:start . 231)\n  (:id . 81))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 239) (:start . 236)\n  (:id . 82))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 250)\n  (:start . 240) (:id . 83))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 255) (:start . 251)\n  (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 257) (:start . 256)\n  (:id . 85))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 266)\n  (:start . 258) (:id . 86))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 274)\n  (:start . 267) (:id . 87))\n ((:tag . "VBN") (:stem . "form") (:form . 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5004191@unknown@formal@none@1@S@This observation supports a model, in which promoter selectivity reflects the selectively increased antiproliferative effect of VD analogues.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "selectivity") (:form . "selectivity") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "antiproliferative") (:form . "antiproliferative")\n  (:end . 117) (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 124)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vd") (:form . "VD") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "analogue") (:form . "analogues") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s454.12) (:did . :|97070945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004192@unknown@formal@none@1@S@Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferon") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PML/RAR") (:form . "PML/RAR") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 94) (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 130)\n  (:start . 121) (:id . 59))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 154)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "retinoid-resistant") (:form . "retinoid-resistant")\n  (:end . 189) (:start . 171) (:id . 67))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 203) (:start . 190) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 208) (:start . 204)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 213) (:start . 209)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s455.1) (:did . :|97074532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004193@unknown@formal@none@1@S@The PML gene is fused to the retinoic acid receptor alpha gene (RAR alpha) in the acute promyelocytic leukemia (APL) 15 ; 17 translocation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 87) (:start . 82)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 101) (:start . 88) (:id . 61))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 110)\n  (:start . 102) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 65))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 119) (:start . 117)\n  (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 121) (:start . 120)\n  (:id . 67))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 124) (:start . 122)\n  (:id . 68))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 138) (:start . 125) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s455.2) (:did . :|97074532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004194@unknown@formal@none@1@S@PML is expressed in diverse tissues and cell lines and localized in the nucleus with a typical speckled pattern.@(((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "JJ") (:stem . "speckled") (:form . "speckled") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s455.3) (:did . :|97074532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004195@unknown@formal@none@1@S@In the bone marrow, it is preferentially expressed in myeloid cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 40) (:start . 26) (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s455.4) (:did . :|97074532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004196@unknown@formal@none@1@S@PML appears to be transcriptionally regulated by class I and II interferons, which raises the possibility that interferons modulate the function and growth and differentiation potential of normal myeloid cells and precursors by activating PML-dependent pathways.@(((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 35) (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 75)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 105)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 175) (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 195)\n  (:start . 189) (:id . 70))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 203)\n  (:start . 196) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 209)\n  (:start . 204) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 224)\n  (:start . 214) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 227) (:start . 225)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 238)\n  (:start . 228) (:id . 76))\n ((:tag . "JJ") (:stem . "pml-dependent") (:form . "PML-dependent")\n  (:end . 252) (:start . 239) (:id . 77))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 261)\n  (:start . 253) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x455.5.1) (:span 83 105)) ((:id . :x455.5.2) (:span 4 11)))\n (:hscopes ((:id . :x455.5.1) (:span 83 261))\n  ((:id . :x455.5.2) (:span 0 75)))\n (:identifiers (:sid . :s455.5) (:did . :|97074532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004197@unknown@formal@none@1@S@Similarly, interferons could act on APL cells, alone or in combination with all-trans retinoic acid (RA), especially if the PML/RAR alpha fusion transcript that results from the t(15;17) is induced by interferon.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "apl") (:form . "APL") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 116)\n  (:start . 106) (:id . 63))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PML/RAR") (:form . "PML/RAR") (:end . 131)\n  (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 144)\n  (:start . 138) (:id . 68))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 155)\n  (:start . 145) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 168)\n  (:start . 161) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t(15;17)") (:form . "t(15;17)") (:end . 186)\n  (:start . 178) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 197)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 211)\n  (:start . 201) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s455.6) (:did . :|97074532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004198@unknown@formal@none@1@S@We report here that PML is expressed at low levels or not expressed in normal circulating human monocytes, lymphocytes, and polymorphonucleate cells, but is markedly induced by interferon; that PML and PML/RAR alpha expression is augmented by interferon in the NB4 APL cell line, which carries the t(15;17), and in APL blasts from patients; that interferon inhibits growth and survival of NB4 APL cells in cooperation with RA; that interferons alone have minimal maturation effect on NB4 cells; and , finally, that interferon gamma, but not alpha or beta, induces maturation and growth suppression of NB4 cells with de novo retinoid resistance, and partially restores RA response.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . 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5004200@unknown@formal@none@1@S@We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) stimulate the differentiation of human monocytes into two phenotypically distinct types of macrophages.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 20) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 48) (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 67) (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 74)\n  (:start . 68) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 82)\n  (:start . 76) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 98)\n  (:start . 88) (:id . 53))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 117) (:start . 99) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 124)\n  (:start . 118) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 131)\n  (:start . 126) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 142)\n  (:start . 133) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 162) (:start . 147) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 171)\n  (:start . 166) (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 181)\n  (:start . 172) (:id . 64))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 186) (:start . 182)\n  (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 190) (:start . 187)\n  (:id . 66))\n ((:tag . "RB") (:stem . "phenotypically") (:form . "phenotypically")\n  (:end . 205) (:start . 191) (:id . 67))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 214)\n  (:start . 206) (:id . 68))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 220)\n  (:start . 215) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 235)\n  (:start . 224) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s456.2) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004201@unknown@formal@none@1@S@However, in vivo, not only CSF but also many other cytokines are produced under various conditions.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 26) (:start . 22)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSF") (:end . 30) (:start . 27)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 39) (:start . 35)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 44) (:start . 40)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 50) (:start . 45)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 60)\n  (:start . 51) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 73)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 87)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s456.3) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004202@unknown@formal@none@1@S@Those cytokines may modulate the differentiation of monocytes by CSFs.@(((:tag . "DT") (:stem . "those") (:form . "Those") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSFs") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x456.4.1) (:span 16 19)))\n (:hscopes ((:id . :x456.4.1) (:span 16 69)))\n (:identifiers (:sid . :s456.4) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004203@unknown@formal@none@1@S@In the present study, we showed that CD14+ adherent human monocytes can differentiate into CD1+relB+ dendritic cells (DC) by the combination of GM-CSF plus interleukin-4 (IL-4) and that they differentiate into tartrate-resistant acid phosphatase ( TRAP ) -positive osteoclast-like multinucleated giant cells (MGC) by the combination of M-CSF plus IL-4.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . 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5004204@unknown@formal@none@1@S@However, the monocyte-derived DC were not terminally differentiated cells;@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 29) (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "terminally") (:form . "terminally") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 67) (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 74) (:start . 73)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x456.6.1) (:span 38 41)))\n (:nscopes ((:id . :x456.6.1) (:span 38 73)))\n (:identifiers (:sid . :s456.6) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004205@unknown@formal@none@1@S@they could still convert to macrophages in response to M-CSF.@(((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "convert") (:form . "convert") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s456.7) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004206@unknown@formal@none@1@S@Tumor necrosis factor-alpha (TNF-alpha) stimulated the terminal differentiation of the DC by downregulating the expression of the M-CSF receptor, cfms mRNA, and aborting the potential to convert to macrophages.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 79) (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "downregulate") (:form . "downregulating")\n  (:end . 107) (:start . 93) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cfms") (:form . "cfms") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "abort") (:form . "aborting") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 183)\n  (:start . 174) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "VB") (:stem . "convert") (:form . "convert") (:end . 194)\n  (:start . 187) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 209)\n  (:start . 198) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s456.8) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004207@unknown@formal@none@1@S@In contrast to IL-4, interferon-gamma (IFN-gamma) had no demonstrable effect on the differentiation of monocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 37) (:start . 21) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "demonstrable") (:form . "demonstrable") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 99) (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x456.9.1) (:span 54 56)))\n (:nscopes ((:id . :x456.9.1) (:span 54 112)))\n (:identifiers (:sid . :s456.9) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004208@unknown@formal@none@1@S@Rather, IFN-gamma antagonized the effect of IL-4 and suppressed the DC and MGC formation induced by GM-CSF + IL-4 and M-CSF + IL-4, respectively.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "antagonize") (:form . "antagonized") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MGC") (:form . "MGC") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 144)\n  (:start . 132) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s456.10) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004210@unknown@formal@none@1@S@Such a diverse pathway of monocyte differentiation may constitute one of the basic mechanisms of immune regulation.@(((:tag . "PDT") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 50) (:start . 35) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VB") (:stem . "constitute") (:form . "constitute") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x456.12.1) (:span 51 54)))\n (:hscopes ((:id . :x456.12.1) (:span 51 114)))\n (:identifiers (:sid . :s456.12) (:did . :|97074543|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004211@unknown@formal@none@1@S@T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s457.1) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004212@unknown@formal@none@1@S@Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology.@(((:tag . "JJ") (:stem . "rheumatoid") (:form . "Rheumatoid") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multistep") (:form . "multistep") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "etiology") (:form . "etiology") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s457.2) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004213@unknown@formal@none@1@S@Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided.@(((:tag . "NN") (:stem . "implication") (:form . "Implication") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 92)\n  (:start . 80) (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "suspect") (:form . "suspected") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 157)\n  (:start . 145) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 174) (:start . 173)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 181)\n  (:start . 175) (:id . 72))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 186) (:start . 182)\n  (:id . 73))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 194)\n  (:start . 187) (:id . 74))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 198) (:start . 195)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 213)\n  (:start . 203) (:id . 77))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 223)\n  (:start . 214) (:id . 78))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 227) (:start . 224)\n  (:id . 79))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 231) (:start . 228)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 236) (:start . 232)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 245)\n  (:start . 237) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x457.3.2) (:span 102 111)))\n (:ncues ((:id . :x457.3.1) (:span 228 231)))\n (:hscopes ((:id . :x457.3.2) (:span 0 157)))\n (:nscopes ((:id . :x457.3.1) (:span 173 245)))\n (:identifiers (:sid . :s457.3) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004214@unknown@formal@none@1@S@Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "infiltrate") (:form . "infiltrating") (:end . 58)\n  (:start . 46) (:id . 52))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "joint") (:form . "joints") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 158) (:start . 143) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BZLF1") (:form . "BZLF1") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "BMLF1") (:form . "BMLF1") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 187)\n  (:start . 182) (:id . 73))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 206) (:start . 188) (:id . 74))\n ((:tag . "JJ") (:stem . "complex-restricted") (:form . "complex-restricted")\n  (:end . 225) (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 233)\n  (:start . 226) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s457.4) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004215@unknown@formal@none@1@S@Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable.@(((:tag . "NNS") (:stem . "response") (:form . "Responses") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 136)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s457.5) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004216@unknown@formal@none@1@S@Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 100)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x457.6.1) (:span 19 26)))\n (:hscopes ((:id . :x457.6.1) (:span 19 100)))\n (:identifiers (:sid . :s457.6) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004217@unknown@formal@none@1@S@They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 103) (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 172)\n  (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x457.7.1) (:span 119 124)))\n (:hscopes ((:id . :x457.7.1) (:span 119 172)))\n (:identifiers (:sid . :s457.7) (:did . :|97079135|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004218@unknown@formal@none@1@S@Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s458.1) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004220@unknown@formal@none@1@S@Recently, it has been shown that RelB knockout mice have no dendritic cells (DC).@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "knockout") (:form . "knockout") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x458.3.1) (:span 57 59)))\n (:nscopes ((:id . :x458.3.1) (:span 57 80)))\n (:identifiers (:sid . :s458.3) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004221@unknown@formal@none@1@S@An overexpression of p50 has been described in follicular dendritic cells (FDC).@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "follicular") (:form . "follicular") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s458.4) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004222@unknown@formal@none@1@S@A constitutive NF-kappa B activity has been reported in mature macrophages.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s458.5) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004223@unknown@formal@none@1@S@This led to the hypothesis that some of the Rel/NF-kappa B proteins were key nuclear factors in functions of accessory cells of the immune response.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 56)\n  (:start . 44) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 147)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s458.6) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004224@unknown@formal@none@1@S@Therefore, we investigated in situ the nuclear localization of Rel/NF-kappa B proteins in accessory cells of the immune system by immunohistochemistry and double labeling by immunofluorescence from five normal human tonsils and five lymph nodes with follicular hyperplasia.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 75)\n  (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 150) (:start . 130) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "labeling") (:form . "labeling") (:end . 170)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 192) (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 197) (:start . 193)\n  (:id . 69))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 202) (:start . 198)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 209)\n  (:start . 203) (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 215)\n  (:start . 210) (:id . 72))\n ((:tag . "NNS") (:stem . "tonsil") (:form . "tonsils") (:end . 223)\n  (:start . 216) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 74))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 232) (:start . 228)\n  (:id . 75))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 238)\n  (:start . 233) (:id . 76))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 244)\n  (:start . 239) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 249) (:start . 245)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "follicular") (:form . "follicular") (:end . 260)\n  (:start . 250) (:id . 79))\n ((:tag . "NN") (:stem . "hyperplasia") (:form . "hyperplasia") (:end . 272)\n  (:start . 261) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s458.7) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004225@unknown@formal@none@1@S@Nuclear p65 and c-Rel proteins were found in all cell types including lymphocytes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s458.8) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004226@unknown@formal@none@1@S@In germinal centers GC, p50, p52, and RelB were found in the nuclei of FDC only and were not detected in the nuclei of CD68+ cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "center") (:form . "centers") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 42) (:start . 38)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 53) (:start . 48)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 67)\n  (:start . 61) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "FDC") (:form . "FDC") (:end . 74) (:start . 71)\n  (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 79) (:start . 75)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 101)\n  (:start . 93) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 115)\n  (:start . 109) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cd68+") (:form . "CD68+") (:end . 124)\n  (:start . 119) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x458.9.1) (:span 89 92)))\n (:nscopes ((:id . :x458.9.1) (:span 84 130)))\n (:identifiers (:sid . :s458.9) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004227@unknown@formal@none@1@S@In T cell areas, p50, p52, and RelB were found in the nuclei of HLA-DR+ cells with an antigen-presenting cell (APC) morphology.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 9) (:start . 5)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 25) (:start . 22)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 35) (:start . 31)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 46) (:start . 41)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 60)\n  (:start . 54) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "hla-dr+") (:form . "HLA-DR+") (:end . 71)\n  (:start . 64) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 85) (:start . 83)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 104) (:start . 86) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 114) (:start . 111)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 67))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 126)\n  (:start . 116) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s458.10) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004228@unknown@formal@none@1@S@p52 and RelB were detected in the nuclei in both CD1a+ and CD68+ cells from the T cell area, whereas p50 was found only in CD68- and CD1a- cells.@(((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd1a+") (:form . "CD1a+") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cd68+") (:form . "CD68+") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 100)\n  (:start . 93) (:id . 62))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 114)\n  (:start . 109) (:id . 65))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 119) (:start . 115)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cd68-") (:form . "CD68-") (:end . 128)\n  (:start . 123) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cd1a-") (:form . "CD1a-") (:end . 138)\n  (:start . 133) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s458.11) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004230@unknown@formal@none@1@S@These results show that , physiologically, high levels of nuclear of p50, p52 and RelB are restricted to accessory cells of the immune system, which include FDC in GC, and DC and macrophages in the T cell zone, that specialized scavenger macrophages from GC do not have detectable levels of p52 and RelB, whereas macrophages from the T cell area, known to present the antigen to T cells, do have both nuclear p52 and RelB, and that in the T cell zone, p52 and RelB are located in nuclei of both CD1a+, CD68+ or both, cells APC, whereas p50 is restricted to CD1a- and CD68- APC.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . 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5004231@unknown@formal@none@1@S@The different patterns of p50, p52 and RelB protein nuclear localization may provide insight into their different roles during the immune response in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 154) (:start . 150)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x458.14.1) (:span 73 76)))\n (:hscopes ((:id . :x458.14.1) (:span 73 154)))\n (:identifiers (:sid . :s458.14) (:did . :|97080592|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004232@unknown@formal@none@1@S@Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DR3") (:form . "DR3") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "domain-containing") (:form . "domain-containing")\n  (:end . 53) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNFR-1") (:form . "TNFR-1") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s459.1) (:did . :|97081063|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004233@unknown@formal@none@1@S@Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the " death domain. "@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "receptor-1") (:form . "receptor-1") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tnfr-1") (:form . "TNFR-1") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 63) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "APO-1") (:form . "APO-1") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 90)\n  (:start . 82) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 100)\n  (:start . 91) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "engage") (:form . "engage") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 126)\n  (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 168) (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 189)\n  (:start . 179) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 195) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 201)\n  (:start . 196) (:id . 76))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 208)\n  (:start . 202) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 78))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 211) (:start . 210)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s459.2) (:did . :|97081063|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004234@unknown@formal@none@1@S@Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "domain-containing") (:form . "domain-containing")\n  (:end . 31) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 38)\n  (:start . 32) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNFR") (:form . "TNFR") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DR3") (:form . "DR3") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 121)\n  (:start . 115) (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 162)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 169)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 176)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s459.3) (:did . :|97081063|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004235@unknown@formal@none@1@S@Expression of DR3 appears to be restricted to tissues enriched in lymphocytes.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DR3") (:form . "DR3") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "restrict") (:form . "restricted") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x459.4.1) (:span 18 25)))\n (:hscopes ((:id . :x459.4.1) (:span 0 77)))\n (:identifiers (:sid . :s459.4) (:did . :|97081063|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004236@unknown@formal@none@1@S@DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE.@(((:tag . "NN") (:stem . "dr3") (:form . "DR3") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 101)\n  (:start . 96) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "FADD") (:form . "FADD") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "FLICE") (:form . "FLICE") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s459.5) (:did . :|97081063|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004237@unknown@formal@none@1@S@Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "DR3") (:form . "DR3") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 43)\n  (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x459.6.1) (:span 10 16)))\n (:hscopes ((:id . :x459.6.1) (:span 10 66)))\n (:identifiers (:sid . :s459.6) (:did . :|97081063|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004238@unknown@formal@none@1@S@Cloning and expression of the Epstein-Barr virus-encoded dUTPase: patients with acute, reactivated or chronic virus infection develop antibodies against the enzyme.@(((:tag . "NNP") (:stem . "Cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "virus-encoded") (:form . "virus-encoded")\n  (:end . 56) (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "dutpase") (:form . "dUTPase") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reactivate") (:form . "reactivated") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 152)\n  (:start . 145) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 163)\n  (:start . 157) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s460.1) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004240@unknown@formal@none@1@S@The active enzyme was expressed in Escherichia coli and in insect cells as a non-fusion protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "FW") (:stem . "escherichia") (:form . "Escherichia") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "insect") (:form . "insect") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "non-fusion") (:form . "non-fusion") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s460.3) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004241@unknown@formal@none@1@S@The protein from E. coli specifically converted dUTP to dUMP and did not react with other dNTPs or NTPs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "convert") (:form . "converted") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "dutp") (:form . "dUTP") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dump") (:form . "dUMP") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "react") (:form . "react") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "dntp") (:form . "dNTPs") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "ntp") (:form . "NTPs") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x460.4.1) (:span 69 72)))\n (:nscopes ((:id . :x460.4.1) (:span 69 103)))\n (:identifiers (:sid . :s460.4) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004242@unknown@formal@none@1@S@Preliminary experiments yielded a Km value of about 0.8 microM for dUTP.@(((:tag . "JJ") (:stem . "preliminary") (:form . "Preliminary") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "yield") (:form . "yielded") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Km") (:form . "Km") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.8") (:form . "0.8") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "dUTP") (:form . "dUTP") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s460.5) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004243@unknown@formal@none@1@S@MAbs against the dUTPase reacted with a protein of approximately 31 kDa in 12-O-tetradecanoyl-phorbol-13-acetate ( TPA ) -stimulated B cells harbouring either type 1 or type 2 EBV.@(((:tag . "NNS") (:stem . "mab") (:form . "MAbs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dutpase") (:form . "dUTPase") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "react") (:form . "reacted") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "CD") (:stem . "31") (:form . "31") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoyl-phorbol-13-acetate")\n  (:form . "12-O-tetradecanoyl-phorbol-13-acetate") (:end . 112) (:start . 75)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "-stimulated") (:form . "-stimulated") (:end . 132)\n  (:start . 121) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "VBG") (:stem . "harbour") (:form . "harbouring") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 165) (:start . 164)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x460.6.1) (:span 152 158 166 168)))\n (:hscopes ((:id . :x460.6.1) (:span 152 175)))\n (:identifiers (:sid . :s460.6) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004244@unknown@formal@none@1@S@The protein was found in untreated cells at low levels, whereas induction of the lytic replication cycle by TPA treatment or by providing the immediate early transactivator BZLF1 in trans resulted in increased expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 151)\n  (:start . 142) (:id . 67))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 172) (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "bzlf1") (:form . "BZLF1") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "tran") (:form . "trans") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 196)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 220)\n  (:start . 210) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s460.7) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004245@unknown@formal@none@1@S@We demonstrated that the virus dUTPase isolated from EBV-infected cells is a phosphoprotein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dutpase") (:form . "dUTPase") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ebv-infected") (:form . "EBV-infected") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 91) (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s460.8) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004246@unknown@formal@none@1@S@The protein expressed in insect cells was used to test for the presence of specific antibodies in sera from normal, healthy carriers and from patients with various diseases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insect") (:form . "insect") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "serum") (:form . "sera") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "carrier") (:form . "carriers") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 163)\n  (:start . 156) (:id . 69))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 172)\n  (:start . 164) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s460.9) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004247@unknown@formal@none@1@S@While the sera of EBV-negative individuals (0/3) or healthy carriers (0/33) did not contain detectable levels of antibodies, patients with mononucleosis (5/18), chronic EBV infection (2/7), EBV reactivation (7/20) and human immunodeficiency virus infection (5/24) showed elevated antibody titres against the enzyme.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "serum") (:form . "sera") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ebv-negative") (:form . "EBV-negative") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . 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(:end . 315) (:start . 314)\n  (:id . 99)))@@@1@58@((:ncues ((:id . :x460.10.1) (:span 80 83)))\n (:nscopes ((:id . :x460.10.1) (:span 80 123)))\n (:identifiers (:sid . :s460.10) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004248@unknown@formal@none@1@S@This indicated that the dUTPase is expressed during EBV replication and reactivation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dutpase") (:form . "dUTPase") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x460.11.1) (:span 5 19)))\n (:hscopes ((:id . :x460.11.1) (:span 5 84)))\n (:identifiers (:sid . :s460.11) (:did . :|97081192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004250@unknown@formal@none@1@S@Prostaglandin E2 induction of binding activity to CRE and AP-2 elements in human T lymphocytes.@(((:tag . "NN") (:stem . "prostaglandin") (:form . "Prostaglandin")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s461.1) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004251@unknown@formal@none@1@S@Prostaglandins of the E series are immunomodulatory agents which exert inhibitory as well as stimulatory effects on a variety of immune responses.@(((:tag . "NNS") (:stem . "prostaglandin") (:form . "Prostaglandins")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 51) (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s461.2) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004252@unknown@formal@none@1@S@Since it is known that PGE2 is able to increase cAMP levels, we investigated whether it can affect gene expression through the activation of the transcription factors which bind enhancer elements in the promoter regions of cAMP-regulated genes.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 76)\n  (:start . 64) (:id . 56))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 98)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 158) (:start . 145) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 186)\n  (:start . 178) (:id . 72))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 211)\n  (:start . 203) (:id . 76))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 219)\n  (:start . 212) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "camp-regulated") (:form . "cAMP-regulated")\n  (:end . 237) (:start . 223) (:id . 79))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 243)\n  (:start . 238) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x461.3.1) (:span 77 84)))\n (:hscopes ((:id . :x461.3.1) (:span 77 243)))\n (:identifiers (:sid . :s461.3) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004253@unknown@formal@none@1@S@Using electrophoretic mobility shift assay, we demonstrated that a short treatment of human T lymphocytes with PGE2 induces specific binding activity to CRE and AP-2, but not AP-1, DNA elements.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 179) (:start . 175)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 193)\n  (:start . 185) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x461.4.1) (:span 171 174)))\n (:nscopes ((:id . :x461.4.1) (:span 171 179)))\n (:identifiers (:sid . :s461.4) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004254@unknown@formal@none@1@S@Since the okadaic acid, a potent protein phosphatase inhibitor, prolongs the induction of the binding activity, phosphorylation events are likely to occur.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "prolong") (:form . "prolongs") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 127) (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x461.5.1) (:span 139 145)))\n (:hscopes ((:id . :x461.5.1) (:span 112 154)))\n (:identifiers (:sid . :s461.5) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004255@unknown@formal@none@1@S@This activity seems to be due to increased cAMP levels because forskolin and IBMX mimic the effects of PGE2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "forskolin") (:form . "forskolin") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IBMX") (:form . "IBMX") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "mimic") (:form . "mimic") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x461.6.1) (:span 14 19)))\n (:hscopes ((:id . :x461.6.1) (:span 0 54)))\n (:identifiers (:sid . :s461.6) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004256@unknown@formal@none@1@S@More interestingly, transfection experiments with CRE-CAT plasmide show that PGE2 activates the transcription of a CRE-containing promoter.@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "interestingly") (:form . "interestingly")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CRE-CAT") (:form . "CRE-CAT") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "plasmide") (:form . "plasmide") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cre-containing") (:form . "CRE-containing")\n  (:end . 129) (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 138)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s461.7) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004257@unknown@formal@none@1@S@These data support the positive role for PGE2 on some immune functions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s461.8) (:did . :|97083501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004258@unknown@formal@none@1@S@Regulation of cytokine and cytokine receptor expression by glucocorticoids.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 74) (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s462.1) (:did . :|97083588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004260@unknown@formal@none@1@S@GCS were also reported to act indirectly by inducing transforming growth factor-beta expression, which in turn blocks T cell immunity.@(((:tag . "NNS") (:stem . "gcs") (:form . "GCS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s462.3) (:did . :|97083588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004261@unknown@formal@none@1@S@In exerting their antiproliferative effects, GCS diffuse into target cells where they bind their cytoplasmic receptor, which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements (GRE), which are located in the promoter region of cytokine genes or , alternatively, through antagonism of the action of transcription factors required for optimal transcriptional activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "exert") (:form . "exerting") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 17)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "antiproliferative") (:form . "antiproliferative")\n  (:end . 35) (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . 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"factors") (:end . 417)\n  (:start . 410) (:id . 107))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 426)\n  (:start . 418) (:id . 108))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 430) (:start . 427)\n  (:id . 109))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 438)\n  (:start . 431) (:id . 110))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 454) (:start . 439) (:id . 111))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 465)\n  (:start . 455) (:id . 112))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 466) (:start . 465)\n  (:id . 113)))@@@1@72@((:hcues ((:id . :x462.4.1) (:span 340 342)))\n (:hscopes ((:id . :x462.4.1) (:span 211 465)))\n (:identifiers (:sid . :s462.4) (:did . :|97083588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004262@unknown@formal@none@1@S@In contrast to their inhibitory effects on cytokine expression, GCS up-regulate cytokine receptor expression that correlates with enhanced cytokine effects on target cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 20)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GCS") (:form . "GCS") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "up-regulate") (:form . "up-regulate") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 155)\n  (:start . 148) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 165)\n  (:start . 159) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s462.5) (:did . :|97083588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004263@unknown@formal@none@1@S@In this review, we summarize the current state of knowledge of the mechanism of action of GCS, including the phenomenon of steroid-induced rebound, which ensues upon GCS withdrawal.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "summarize") (:form . "summarize") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GCS") (:form . "GCS") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 104)\n  (:start . 95) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 119)\n  (:start . 109) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "steroid-induced") (:form . "steroid-induced")\n  (:end . 138) (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "rebound") (:form . "rebound") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 153)\n  (:start . 148) (:id . 68))\n ((:tag . "VBZ") (:stem . "ensue") (:form . "ensues") (:end . 160)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GCS") (:form . "GCS") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "withdrawal") (:form . "withdrawal") (:end . 180)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s462.6) (:did . :|97083588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004264@unknown@formal@none@1@S@The Oct-2 transcription factor .@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 32) (:start . 31)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s463.1) (:did . :|97083787|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004265@unknown@formal@none@1@S@The Oct-2 transcription factor is a member of the POU (Pit-Oct-Unc) family of transcription factors and is expressed only in B lymphocytes and in neuronal cells but not in other cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Pit-Oct-Unc") (:form . "Pit-Oct-Unc") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 138)\n  (:start . 127) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "neuronal") (:form . "neuronal") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 168) (:start . 165)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 177)\n  (:start . 172) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 188)\n  (:start . 183) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x463.2.1) (:span 165 168)))\n (:nscopes ((:id . :x463.2.1) (:span 165 188)))\n (:identifiers (:sid . :s463.2) (:did . :|97083787|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004266@unknown@formal@none@1@S@The primary RNA transcript of the gene is subject to alternative splicing to yield different variants which can either activate or repress gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "subject") (:form . "subject") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "yield") (:form . "yield") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s463.3) (:did . :|97083787|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004267@unknown@formal@none@1@S@The forms produced in B lymphocytes have a predominantly activating effect on gene expression whereas those produced in neuronal cells have a predominantly inhibitory effect and can repress the expression of both the herpes simplex virus immediate-early genes and the cellular tyrosine hydroxylase gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "neuronal") (:form . "neuronal") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 155) (:start . 142) (:id . 64))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 166)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 173)\n  (:start . 167) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 67))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 181) (:start . 178)\n  (:id . 68))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 189)\n  (:start . 182) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 204)\n  (:start . 194) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 212) (:start . 208)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "NN") (:stem . "herpes") (:form . "herpes") (:end . 223)\n  (:start . 217) (:id . 75))\n ((:tag . "NN") (:stem . "simplex") (:form . "simplex") (:end . 231)\n  (:start . 224) (:id . 76))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 237)\n  (:start . 232) (:id . 77))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 253) (:start . 238) (:id . 78))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 259)\n  (:start . 254) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 263) (:start . 260)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 267) (:start . 264)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 276)\n  (:start . 268) (:id . 82))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 285)\n  (:start . 277) (:id . 83))\n ((:tag . "NN") (:stem . "hydroxylase") (:form . "hydroxylase") (:end . 297)\n  (:start . 286) (:id . 84))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 302) (:start . 298)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 303) (:start . 302)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s463.4) (:did . :|97083787|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004268@unknown@formal@none@1@S@Thus Oct-2 plays an important role in the regulation of cellular gene expression in both B cells and neuronal cells as well as in the control of viral latency.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "neuronal") (:form . "neuronal") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 150)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 158)\n  (:start . 151) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s463.5) (:did . :|97083787|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004270@unknown@formal@none@1@S@TSC2 is a gene on chromosome 16p13.3 associated with the autosomal dominant neurocutaneous disorder, tuberous sclerosis complex (TSC).@(((:tag . "NNP") (:stem . "TSC2") (:form . "TSC2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 28)\n  (:start . 18) (:id . 47))\n ((:tag . "NN") (:stem . "16p13.3") (:form . "16p13.3") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "autosomal") (:form . "autosomal") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "neurocutaneous") (:form . "neurocutaneous")\n  (:end . 90) (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tuberous") (:form . "tuberous") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "sclerosis") (:form . "sclerosis") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TSC") (:form . "TSC") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s464.2) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004271@unknown@formal@none@1@S@By using a partial nucleotide sequence from the cloned TSC2 and polymerase chain reaction methodology, we constructed a digoxigenin-labeled complementary DNA probe to examine TSC2 gene expression in autopsy- or biopsy-derived human tissues by in situ hybridization.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "tsc2") (:form . "TSC2") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "methodology") (:form . "methodology") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "construct") (:form . "constructed") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "digoxigenin-labeled")\n  (:form . "digoxigenin-labeled") (:end . 139) (:start . 120) (:id . 61))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 153) (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 163)\n  (:start . 158) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 174)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "tsc2") (:form . "TSC2") (:end . 179) (:start . 175)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 195)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 70))\n ((:tag . "NN") (:stem . "autopsy-") (:form . "autopsy-") (:end . 207)\n  (:start . 199) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 210) (:start . 208)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "biopsy-derived") (:form . "biopsy-derived")\n  (:end . 225) (:start . 211) (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 231)\n  (:start . 226) (:id . 74))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 239)\n  (:start . 232) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 242) (:start . 240)\n  (:id . 76))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 245) (:start . 243)\n  (:id . 77))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 250) (:start . 246)\n  (:id . 78))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 264) (:start . 251) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s464.3) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004272@unknown@formal@none@1@S@TSC2 messenger RNA was widely expressed in various cell types throughout the body, including epithelia, lymphocytes, and cells with endocrine functions, e.g., adrenal cortex and anterior pituitary.@(((:tag . "NN") (:stem . "tsc2") (:form . "TSC2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "epithelia") (:form . "epithelia") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 173)\n  (:start . 167) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "anterior") (:form . "anterior") (:end . 186)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "pituitary") (:form . "pituitary") (:end . 196)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s464.4) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004273@unknown@formal@none@1@S@It was prominently and selectively (within the central nervous system) expressed in pyramidal cells of the cerebral cortex and other motor neurons, e.g., in spinal cord and brainstem nuclei.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "prominently") (:form . "prominently") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pyramidal") (:form . "pyramidal") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cerebral") (:form . "cerebral") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "motor") (:form . "motor") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "neuron") (:form . "neurons") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "spinal") (:form . "spinal") (:end . 163)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "brainstem") (:form . "brainstem") (:end . 182)\n  (:start . 173) (:id . 73))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 189)\n  (:start . 183) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s464.5) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004274@unknown@formal@none@1@S@Visceral TSC2 expression was comparable in autopsy tissues from patients with and without TSC;@(((:tag . "JJ") (:stem . "visceral") (:form . "Visceral") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TSC2") (:form . "TSC2") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "autopsy") (:form . "autopsy") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "NNP") (:stem . "TSC") (:form . "TSC") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x464.6.1) (:span 82 89)))\n (:nscopes ((:id . :x464.6.1) (:span 82 93)))\n (:identifiers (:sid . :s464.6) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004275@unknown@formal@none@1@S@TSC2 messenger RNA expression was most prominent in cells with a rapid mitotic rate and turnover, e.g., epithelia and lymphocytes, with central nervous system pyramidal cells and other neurons being an obvious exception, and/or in cells with important secretory/transport functions.@(((:tag . "NN") (:stem . "tsc2") (:form . "TSC2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mitotic") (:form . "mitotic") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "epithelia") (:form . "epithelia") (:end . 113)\n  (:start . 104) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 129)\n  (:start . 118) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "JJ") (:stem . "pyramidal") (:form . "pyramidal") (:end . 168)\n  (:start . 159) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "NNS") (:stem . "neuron") (:form . "neurons") (:end . 192)\n  (:start . 185) (:id . 73))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 198) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 201) (:start . 199)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 209)\n  (:start . 202) (:id . 76))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 219)\n  (:start . 210) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 227)\n  (:start . 221) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 236)\n  (:start . 231) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 241) (:start . 237)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 251)\n  (:start . 242) (:id . 83))\n ((:tag . "NN") (:stem . "secretory/transport")\n  (:form . "secretory/transport") (:end . 271) (:start . 252) (:id . 84))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 281)\n  (:start . 272) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s464.7) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004276@unknown@formal@none@1@S@This widespread expression of the TSC2 gene supports the view that it encodes a protein vital to cell growth and metabolism or one that functions as a tumor/growth suppressor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "widespread") (:form . "widespread") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tsc2") (:form . "TSC2") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "JJ") (:stem . "vital") (:form . "vital") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 145)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tumor/growth") (:form . "tumor/growth") (:end . 163)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 174)\n  (:start . 164) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x464.8.1) (:span 124 126)))\n (:hscopes ((:id . :x464.8.1) (:span 78 174)))\n (:identifiers (:sid . :s464.8) (:did . :|97087515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004277@unknown@formal@none@1@S@Cell specific expression of human Bruton 's agammaglobulinemia tyrosine kinase gene (Btk) is regulated by Sp1- and Spi-1/PU.1-family members.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Bruton") (:form . "Bruton") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "agammaglobulinemia") (:form . "agammaglobulinemia")\n  (:end . 62) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Btk") (:form . "Btk") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Sp1-") (:form . "Sp1-") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Spi-1/PU.1-family") (:form . "Spi-1/PU.1-family")\n  (:end . 132) (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s465.1) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004278@unknown@formal@none@1@S@Bruton 's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase involved in the human disease X-linked agammaglobulinemia (XLA).@(((:tag . "NNP") (:stem . "Bruton") (:form . "Bruton") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "agammaglobulinemia") (:form . "agammaglobulinemia")\n  (:end . 28) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 44)\n  (:start . 38) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Btk") (:form . "Btk") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "x-linked") (:form . "X-linked") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "agammaglobulinemia") (:form . "agammaglobulinemia")\n  (:end . 141) (:start . 123) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "XLA") (:form . "XLA") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s465.2) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004280@unknown@formal@none@1@S@For this expression pattern the first 280 bp upstream of the major transcriptional start site seems to be sufficient.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "280") (:form . "280") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 82) (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x465.4.1) (:span 94 99)))\n (:hscopes ((:id . :x465.4.1) (:span 28 116)))\n (:identifiers (:sid . :s465.4) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004281@unknown@formal@none@1@S@In vitro footprinting analysis within this part of the promoter revealed two Sp1 binding sites as well as a PU-box.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pu-box") (:form . "PU-box") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s465.5) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004282@unknown@formal@none@1@S@The transcription factor Spi-1/PU.1 as well as the closely related factor Spi-B bound to the PU-box in B-cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "spi-1/pu.1") (:form . "Spi-1/PU.1") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PU-box") (:form . "PU-box") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s465.6) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004283@unknown@formal@none@1@S@In the erythroleukemia cell line K562, due to the absence of Spi-B, only PU.1 bound to the Btk promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 22) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 77) (:start . 73)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Btk") (:form . "Btk") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 103)\n  (:start . 95) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s465.7) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004284@unknown@formal@none@1@S@Mutation of either site reduced the expression in transient transfection experiments.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s465.8) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004285@unknown@formal@none@1@S@However, mutation of the PU box had no effect in the T-cell line Jurkat, where none of the Spi-1 family members is expressed.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PU") (:form . "PU") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 45)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 59)\n  (:start . 53) (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 64) (:start . 60)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 71)\n  (:start . 65) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 78) (:start . 73)\n  (:id . 58))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 61))\n ((:tag . "NN") (:stem . "spi-1") (:form . "Spi-1") (:end . 96) (:start . 91)\n  (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 103)\n  (:start . 97) (:id . 63))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 111)\n  (:start . 104) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 124)\n  (:start . 115) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x465.9.1) (:span 79 83)) ((:id . :x465.9.2) (:span 36 38)))\n (:nscopes ((:id . :x465.9.1) (:span 79 124))\n  ((:id . :x465.9.2) (:span 36 71)))\n (:identifiers (:sid . :s465.9) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004286@unknown@formal@none@1@S@In addition Spi-B as well as PU.1 were able to transactivate Btk expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 60) (:start . 47) (:id . 52))\n ((:tag . "NNP") (:stem . "Btk") (:form . "Btk") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s465.10) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004287@unknown@formal@none@1@S@In fetal liver of PU.1-/- mice, which lack lymphoid and myeloid cells, expression of Btk was reduced two- to threefold but not abolished.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pu.1-/-") (:form . "PU.1-/-") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Btk") (:form . "Btk") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 100)\n  (:start . 93) (:id . 60))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "RB") (:stem . "threefold") (:form . "threefold") (:end . 118)\n  (:start . 109) (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x465.11.1) (:span 123 126))\n  ((:id . :x465.11.2) (:span 38 42)))\n (:nscopes ((:id . :x465.11.1) (:span 123 136))\n  ((:id . :x465.11.2) (:span 38 69)))\n (:identifiers (:sid . :s465.11) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004288@unknown@formal@none@1@S@Collectively this study shows that expression of the Btk gene is regulated by the combined action of Sp1- and PU.1-family members.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Btk") (:form . "Btk") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Sp1-") (:form . "Sp1-") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PU.1-family") (:form . "PU.1-family") (:end . 121)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s465.12) (:did . :|97088634|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004290@unknown@formal@none@1@S@The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is a key regulator of lymphocyte proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s466.2) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004291@unknown@formal@none@1@S@IL-2R alpha is rapidly and potently induced in T cells in response to mitogenic stimuli.@(((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s466.3) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004292@unknown@formal@none@1@S@Interleukin 2 (IL-2) stimulates IL-2R alpha. transcription, thereby amplifying expression of its own high-affinity receptor.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha.") (:form . "alpha.") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "VBG") (:stem . "amplify") (:form . "amplifying") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s466.4) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004293@unknown@formal@none@1@S@IL-2R alpha transcription is at least in part controlled by two positive regulatory regions, PRRI and PRRII.@(((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PRRI") (:form . "PRRI") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PRRII") (:form . "PRRII") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s466.5) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004294@unknown@formal@none@1@S@PRRI is an inducible proximal enhancer, located between nucleotides -276 and -244, which contains NF-kappaB and SRE/CArG motifs.@(((:tag . "NNP") (:stem . "PRRI") (:form . "PRRI") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "CD") (:stem . "-276") (:form . "-276") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "-244") (:form . "-244") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SRE/CArG") (:form . "SRE/CArG") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s466.6) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004295@unknown@formal@none@1@S@PRRII is a T-cell-specific enhancer, located between nucleotides -137 and -64, which binds the T-cell-specific Ets protein Elf-1 and HMG-I(Y) proteins.@(((:tag . "NNP") (:stem . "PRRII") (:form . "PRRII") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 26) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "CD") (:stem . "-137") (:form . "-137") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-64") (:form . "-64") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 110) (:start . 95) (:id . 58))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s466.7) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004296@unknown@formal@none@1@S@However, none of these proximal regions account for the induction of IL-2R alpha transcription by IL-2.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "VBP") (:stem . "account") (:form . "account") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s466.8) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004297@unknown@formal@none@1@S@To find new regulatory regions of the IL-2R alpha gene, 8.5 kb of the 5' end noncoding sequence of the IL-2R alpha gene have been sequenced.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "CD") (:stem . "8.5") (:form . "8.5") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 72) (:start . 71)\n  (:id . 58))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 76) (:start . 73)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "noncoding") (:form . "noncoding") (:end . 86)\n  (:start . 77) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 95)\n  (:start . 87) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 108)\n  (:start . 103) (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 114)\n  (:start . 109) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 124) (:start . 120)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 129) (:start . 125)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 139)\n  (:start . 130) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s466.9) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004298@unknown@formal@none@1@S@We identified an 86-nucleotide fragment that is 90 % identical to the recently characterized murine IL-2-responsive element (mIL-2rE).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "86-nucleotide") (:form . "86-nucleotide")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "il-2-responsive") (:form . "IL-2-responsive")\n  (:end . 115) (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mil-2re") (:form . "mIL-2rE") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s466.10) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004300@unknown@formal@none@1@S@PRRIII contains a Stat protein binding site that overlaps with an EBS motif (GASd/EBSd).@(((:tag . "NNP") (:stem . "PRRIII") (:form . "PRRIII") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EBS") (:form . "EBS") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GASd/EBSd") (:form . "GASd/EBSd") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s466.12) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004301@unknown@formal@none@1@S@These are essential for IL-2 inducibility of PRRIII/CAT reporter constructs.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PRRIII/CAT") (:form . "PRRIII/CAT") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s466.13) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004302@unknown@formal@none@1@S@IL-2 induced the binding of Stat5a and b proteins to the human GASd element.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Stat5a") (:form . "Stat5a") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "b") (:form . "b") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gasd") (:form . "GASd") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s466.14) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004303@unknown@formal@none@1@S@To confirm the physiological relevance of these findings, we carried out in vivo footprinting experiments which showed that stimulation of IL-2R alpha expression correlated with occupancy of the GASd element.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "carry") (:form . "carried") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 161)\n  (:start . 151) (:id . 65))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 172)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 187)\n  (:start . 178) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gasd") (:form . "GASd") (:end . 199) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 207)\n  (:start . 200) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s466.15) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004304@unknown@formal@none@1@S@Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gasd/ebsd") (:form . "GASd/EBSd") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 121) (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 165) (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 175)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x466.16.1) (:span 89 96)))\n (:hscopes ((:id . :x466.16.1) (:span 89 175)))\n (:identifiers (:sid . :s466.16) (:did . :|97098661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004305@unknown@formal@none@1@S@Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.@(((:tag . "NNP") (:stem . "Association") (:form . "Association") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TRAF1") (:form . "TRAF1") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "traf3") (:form . "TRAF3") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 59)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 104) (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 119) (:start . 105) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s467.1) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004306@unknown@formal@none@1@S@The Epstein-Barr virus (EBV) transforming protein LMP1 appears to be a constitutively activated tumor necrosis factor receptor (TNFR) on the basis of an intrinsic ability to aggregate in the plasma membrane and an association of its cytoplasmic carboxyl terminus (CT) with TNFR-associated factors (TRAFs).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "transform") (:form . 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"TNFR-associated")\n  (:end . 288) (:start . 273) (:id . 89))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 296)\n  (:start . 289) (:id . 90))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 298) (:start . 297)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAFs") (:end . 303)\n  (:start . 298) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 304) (:start . 303)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x467.2.1) (:span 55 62)))\n (:hscopes ((:id . :x467.2.1) (:span 0 304)))\n (:identifiers (:sid . :s467.2) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004307@unknown@formal@none@1@S@We now show that in EBV-transformed B lymphocytes most of TRAF1 or TRAF3 and 5 % of TRAF2 are associated with LMP1 and that most of LMP1 is associated with TRAF1 or TRAF3.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 35) (:start . 20) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TRAF1") (:form . "TRAF1") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TRAF3") (:form . "TRAF3") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 104)\n  (:start . 94) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 114) (:start . 110)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 65))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 136) (:start . 132)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 139) (:start . 137)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 150)\n  (:start . 140) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TRAF1") (:form . "TRAF1") (:end . 161)\n  (:start . 156) (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TRAF3") (:form . "TRAF3") (:end . 170)\n  (:start . 165) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s467.3) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004308@unknown@formal@none@1@S@TRAF1, TRAF2, and TRAF3 bind to a single site in the LMP1 CT corresponding to amino acids (aa) 199 to 214, within a domain which is important for B-lymphocyte growth transformation (aa 187 to 231).@(((:tag . "NNP") (:stem . "TRAF1") (:form . "TRAF1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "traf3") (:form . "TRAF3") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 40)\n  (:start . 34) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 45) (:start . 41)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 57) (:start . 53)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ct") (:form . "CT") (:end . 60) (:start . 58)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 74)\n  (:start . 61) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 83) (:start . 78)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "aa") (:form . "aa") (:end . 93) (:start . 91)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 63))\n ((:tag . "CD") (:stem . "199") (:form . "199") (:end . 98) (:start . 95)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 65))\n ((:tag . "CD") (:stem . "214") (:form . "214") (:end . 105) (:start . 102)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 67))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 113)\n  (:start . 107) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 69))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 122)\n  (:start . 116) (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 128)\n  (:start . 123) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 141)\n  (:start . 132) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 158) (:start . 146) (:id . 75))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 165)\n  (:start . 159) (:id . 76))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 180) (:start . 166) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 182) (:start . 181)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "aa") (:form . "aa") (:end . 184) (:start . 182)\n  (:id . 79))\n ((:tag . "CD") (:stem . "187") (:form . "187") (:end . 188) (:start . 185)\n  (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 81))\n ((:tag . "CD") (:stem . "231") (:form . "231") (:end . 195) (:start . 192)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s467.4) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004310@unknown@formal@none@1@S@The negative effects of point mutations in the LMP1(1-231) core TRAF binding motif on TRAF binding and NF-kappaB activation genetically link the TRAFs to LMP1(1-231)-mediated NF-kappaB activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "LMP1(1-231)") (:form . "LMP1(1-231)") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "traf") (:form . "TRAF") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "VBP") (:stem . "link") (:form . "link") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "traf") (:form . "TRAFs") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "LMP1(1-231)-mediated")\n  (:form . "LMP1(1-231)-mediated") (:end . 174) (:start . 154) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 184)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 195)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s467.6) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004311@unknown@formal@none@1@S@NF-kappaB activation by LMP1(1-231) is likely to be mediated by TRAF1/TRAF2 heteroaggregates since TRAF1 is unique among the TRAFs in coactivating NF-kappaB with LMP1(1-231), a TRAF2 dominant-negative mutant can block LMP1(1-231)-mediated NF-kappaB activation as well as TRAF1 coactivation, and 30 % of TRAF2 is associated with TRAF1 in EBV-transformed B cells.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LMP1(1-231)") (:form . "LMP1(1-231)") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . 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5004312@unknown@formal@none@1@S@TRAF3 is a negative modulator of LMP1(1-231)-mediated NF-kappaB activation.@(((:tag . "NNP") (:stem . "TRAF3") (:form . "TRAF3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "modulator") (:form . "modulator") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LMP1(1-231)-mediated")\n  (:form . "LMP1(1-231)-mediated") (:end . 53) (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s467.8) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004313@unknown@formal@none@1@S@Surprisingly, TRAF1, -2, or -3 does not interact with the terminal LMP1 CT aa 333 to 386 which can independently mediate NF-kappaB activation.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TRAF1") (:form . "TRAF1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-2") (:form . "-2") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "CD") (:stem . "-3") (:form . "-3") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 35) (:start . 31)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 48)\n  (:start . 40) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 66)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CT") (:form . "CT") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "aa") (:form . "aa") (:end . 77) (:start . 75)\n  (:id . 58))\n ((:tag . "CD") (:stem . "333") (:form . "333") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 60))\n ((:tag . "CD") (:stem . "386") (:form . "386") (:end . 88) (:start . 85)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 98) (:start . 95)\n  (:id . 63))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 112) (:start . 99) (:id . 64))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 120)\n  (:start . 113) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 130)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x467.9.1) (:span 36 39)))\n (:nscopes ((:id . :x467.9.1) (:span 36 141)))\n (:identifiers (:sid . :s467.9) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004314@unknown@formal@none@1@S@The constitutive association of TRAFs with LMP1 through the aa 187 to 231 domain which is important in NF-kappaB activation and primary B-lymphocyte growth transformation implicates TRAF aggregation in LMP1 signaling.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "traf") (:form . "TRAFs") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "aa") (:form . "aa") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "CD") (:stem . "187") (:form . "187") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "CD") (:stem . "231") (:form . "231") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 148) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 170) (:start . 156) (:id . 66))\n ((:tag . "VBZ") (:stem . "implicate") (:form . "implicates") (:end . 181)\n  (:start . 171) (:id . 67))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 186) (:start . 182)\n  (:id . 68))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 198)\n  (:start . 187) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 206) (:start . 202)\n  (:id . 71))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 216)\n  (:start . 207) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s467.10) (:did . :|97098688|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004315@unknown@formal@none@1@S@CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 32) (:start . 14) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-igm") (:form . "anti-IgM") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 126)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x468.1.1) (:span 10 13)))\n (:nscopes ((:id . :x468.1.1) (:span 10 82)))\n (:identifiers (:sid . :s468.1) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004316@unknown@formal@none@1@S@In this study we analyzed the effect of CD40 stimulation on the activity and nuclear appearance of Rel/nuclear factor kappaB (NF-kappaB) factors in primary murine B lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "rel/nuclear") (:form . "Rel/nuclear") (:end . 110)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 162)\n  (:start . 156) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 176)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s468.2) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004317@unknown@formal@none@1@S@We show that triggering of CD40 signaling pathway ( s ) by CD40 ligands expressed on L cells led to strong activation of an NF-kappaB-controlled beta-globin reporter gene in primary B lymphocytes from transgenic mice.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "s") (:form . "s") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 106)\n  (:start . 100) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nf-kappab-controlled")\n  (:form . "NF-kappaB-controlled") (:end . 144) (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 156)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 181)\n  (:start . 174) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 195)\n  (:start . 184) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 200) (:start . 196)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 211)\n  (:start . 201) (:id . 75))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 216)\n  (:start . 212) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s468.3) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004318@unknown@formal@none@1@S@Analyses of nuclear translocation of individual members of Rel proteins after CD40 induction of primary B cells showed a strong and long-lasting accumulation of RelB and, less pronounced, of c-Rel.@(((:tag . "NNS") (:stem . "analysis") (:form . "Analyses") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "long-lasting") (:form . "long-lasting") (:end . 144)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 157)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 186)\n  (:start . 176) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s468.4) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004320@unknown@formal@none@1@S@CD40 induced not only nuclear translocation but also de novo synthesis of RelB RNA and protein.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s468.6) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004321@unknown@formal@none@1@S@S107 plasmacytoma cells, which express CD40 but are defective for the nuclear appearance of p50/p65-NF-kappaB, do not express RelB after CD40 stimulation.@(((:tag . "NNP") (:stem . "S107") (:form . "S107") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "p50/p65-NF-kappaB") (:form . "p50/p65-NF-kappaB")\n  (:end . 109) (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 153)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x468.7.1) (:span 114 117)))\n (:nscopes ((:id . :x468.7.1) (:span 114 153)))\n (:identifiers (:sid . :s468.7) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004322@unknown@formal@none@1@S@In S107 cells stably transfected with relB genes, stimulation of nuclear RelB translocation by CD40 was observed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "s107") (:form . "S107") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "relb") (:form . "relB") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 91) (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s468.8) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004323@unknown@formal@none@1@S@These results indicate that stimulation of CD40 signaling pathways exerts a long-lasting stimulatory effect on both the transcription and nuclear translocation of RelB.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long-lasting") (:form . "long-lasting") (:end . 88)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 145)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 159) (:start . 146) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 167) (:start . 163)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x468.9.1) (:span 14 27)))\n (:hscopes ((:id . :x468.9.1) (:span 14 167)))\n (:identifiers (:sid . :s468.9) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004324@unknown@formal@none@1@S@Since LPS and anti-IgM were unable to activate RelB, CD40 appears to trigger a special program of gene expression involved in the proliferation and/or differentiation of B lymphocytes.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "anti-IgM") (:form . "anti-IgM") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "special") (:form . "special") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 143) (:start . 130) (:id . 65))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 150)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 166) (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 183)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x468.10.1) (:span 144 150))\n  ((:id . :x468.10.2) (:span 58 65)))\n (:ncues ((:id . :x468.10.3) (:span 28 34)))\n (:hscopes ((:id . :x468.10.1) (:span 130 166))\n  ((:id . :x468.10.2) (:span 53 183)))\n (:nscopes ((:id . :x468.10.3) (:span 28 51)))\n (:identifiers (:sid . :s468.10) (:did . :|97098712|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004325@unknown@formal@none@1@S@Sterol dependent LDL-receptor gene transcription in lymphocytes from normal and CML patients.@(((:tag . "NNP") (:stem . "Sterol") (:form . "Sterol") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "LDL-receptor") (:form . "LDL-receptor") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 75)\n  (:start . 69) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s469.1) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004326@unknown@formal@none@1@S@Sterol regulatory element (SRE) has been recognized to regulate various key genes coding for especially low density lipoprotein ( LDL ) -receptor, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and HMG-CoA synthase known to play a crucial role in the cholesterol feedback mechanism.@(((:tag . "NNP") (:stem . "Sterol") (:form . "Sterol") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 88) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "-receptor") (:form . "-receptor") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "3-hydroxy-3-methylglutaryl")\n  (:form . "3-hydroxy-3-methylglutaryl") (:end . 173) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "coenzyme") (:form . "coenzyme") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HMG-CoA") (:form . "HMG-CoA") (:end . 193)\n  (:start . 186) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "reductase") (:form . "reductase") (:end . 204)\n  (:start . 195) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HMG-CoA") (:form . "HMG-CoA") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 225)\n  (:start . 217) (:id . 76))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 231)\n  (:start . 226) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 234) (:start . 232)\n  (:id . 78))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 239) (:start . 235)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 241) (:start . 240)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 249)\n  (:start . 242) (:id . 81))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 254) (:start . 250)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 257) (:start . 255)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 261) (:start . 258)\n  (:id . 84))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 273)\n  (:start . 262) (:id . 85))\n ((:tag . "NN") (:stem . "feedback") (:form . "feedback") (:end . 282)\n  (:start . 274) (:id . 86))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 292)\n  (:start . 283) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s469.2) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004327@unknown@formal@none@1@S@The deranged cholesterol feedback mechanism has been widely recognised in initiation as well as progression of various types of cancers including chronic myeloid leukaemia (CML).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "derange") (:form . "deranged") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "feedback") (:form . "feedback") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "VBN") (:stem . "recognise") (:form . "recognised") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cancer") (:form . "cancers") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 153)\n  (:start . 146) (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s469.3) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004328@unknown@formal@none@1@S@Consequently, the present study was addressed to understand this phenomenon and revealed the existence of a unique 47 kDa protein factor having affinity for this SRE sequence in lymphocytes from normal subjects as well as its absence in lymphocytes from untreated CML patients.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "address") (:form . "addressed") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 189)\n  (:start . 178) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 194) (:start . 190)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 213) (:start . 211)\n  (:id . 75))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 218) (:start . 214)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 221) (:start . 219)\n  (:id . 77))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 233)\n  (:start . 226) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 248)\n  (:start . 237) (:id . 81))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 253) (:start . 249)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 263)\n  (:start . 254) (:id . 83))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 267) (:start . 264)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 276)\n  (:start . 268) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s469.4) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004330@unknown@formal@none@1@S@Further, an inverse relationship was also observed between sterol modulated LDL-receptor gene transcription and the binding affinity of this 47 kDa factor to the SRE sequence.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "sterol") (:form . "sterol") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "VBD") (:stem . "modulate") (:form . "modulated") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "LDL-receptor") (:form . "LDL-receptor") (:end . 88)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 154)\n  (:start . 148) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s469.6) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004331@unknown@formal@none@1@S@Based upon these results we propose that alpha-interferon through its receptor initiates phosphatidic acid dependent signalling which in turn regulates the affinity of 47 kDa sterol regulatory element binding factor as well as LDL-receptor gene transcription in lymphocytes from CML patients.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha-interferon") (:form . "alpha-interferon")\n  (:end . 57) (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "phosphatidic") (:form . "phosphatidic") (:end . 101)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 116)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 127)\n  (:start . 117) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 62))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 170) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "sterol") (:form . "sterol") (:end . 181)\n  (:start . 175) (:id . 67))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 192)\n  (:start . 182) (:id . 68))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 200)\n  (:start . 193) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 208)\n  (:start . 201) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 215)\n  (:start . 209) (:id . 71))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 218) (:start . 216)\n  (:id . 72))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 223) (:start . 219)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 226) (:start . 224)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "LDL-receptor") (:form . "LDL-receptor")\n  (:end . 239) (:start . 227) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 244) (:start . 240)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 258) (:start . 245) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 261) (:start . 259)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 273)\n  (:start . 262) (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 278) (:start . 274)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 282) (:start . 279)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 291)\n  (:start . 283) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x469.7.1) (:span 28 35)))\n (:hscopes ((:id . :x469.7.1) (:span 28 291)))\n (:identifiers (:sid . :s469.7) (:did . :|97103140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004332@unknown@formal@none@1@S@Effects of Ara-C on neutral sphingomyelinase and mitogen- and stress-activated protein kinases in T-lymphocyte cell lines.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ara-C") (:form . "Ara-C") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "neutral") (:form . "neutral") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "sphingomyelinase") (:form . "sphingomyelinase")\n  (:end . 44) (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mitogen-") (:form . "mitogen-") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "stress-activated") (:form . "stress-activated")\n  (:end . 78) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 94)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 110) (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 121)\n  (:start . 116) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s470.1) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004333@unknown@formal@none@1@S@Neutral sphingomyelinase (SMase) can be activated by extracellular signals to produce ceramide, which may affect mitogen-activated protein kinase (MAPK) activities.@(((:tag . "JJ") (:stem . "neutral") (:form . "Neutral") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "sphingomyelinase") (:form . "sphingomyelinase")\n  (:end . 24) (:start . 8) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SMase") (:form . "SMase") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 66) (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "ceramide") (:form . "ceramide") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 130) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x470.2.1) (:span 102 105)))\n (:hscopes ((:id . :x470.2.1) (:span 102 163)))\n (:identifiers (:sid . :s470.2) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004334@unknown@formal@none@1@S@Neutral SMase activity was assessed in membranes from Jurkat, a human T-cell line, and EL4, a murine T-cell line.@(((:tag . "JJ") (:stem . "neutral") (:form . "Neutral") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "SMase") (:form . "SMase") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EL4") (:form . "EL4") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 100)\n  (:start . 94) (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 107)\n  (:start . 101) (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s470.3) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004335@unknown@formal@none@1@S@Ara-C activated SMase with 10 minutes in both Jurkat and EL4 cells, while phorbol ester (PMA) had no effect.@(((:tag . "NNP") (:stem . "Ara-C") (:form . "Ara-C") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "smase") (:form . "SMase") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "el4") (:form . "EL4") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 107)\n  (:start . 101) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x470.4.1) (:span 98 100)))\n (:nscopes ((:id . :x470.4.1) (:span 98 107)))\n (:identifiers (:sid . :s470.4) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004336@unknown@formal@none@1@S@PMA, but not Ara-C or ceramides, activated ERK MAPKS, in Jurkat and EL4.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ara-C") (:form . "Ara-C") (:end . 18) (:start . 13)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ceramide") (:form . "ceramides") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . "NNP") (:stem . "ERK") (:form . "ERK") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MAPKS") (:form . "MAPKS") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 63)\n  (:start . 57) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EL4") (:form . "EL4") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x470.5.1) (:span 9 12)))\n (:nscopes ((:id . :x470.5.1) (:span 9 31)))\n (:identifiers (:sid . :s470.5) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004337@unknown@formal@none@1@S@PMA acted synergistically with ionomycin to activate JNK MAPKs in Jurkat and EL4 within 10 minutes.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "act") (:form . "acted") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPKs") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EL4") (:form . "EL4") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s470.6) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004338@unknown@formal@none@1@S@Ara-C activated JNKs only after prolonged incubation (90-120 minutes).@(((:tag . "NNP") (:stem . "Ara-C") (:form . "Ara-C") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "jnk") (:form . "JNKs") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "CD") (:stem . "90-120") (:form . "90-120") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s470.7) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004340@unknown@formal@none@1@S@The effects of Ara-C on JNK activity may be mediated through secondary response pathways.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ara-C") (:form . "Ara-C") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x470.9.1) (:span 37 40)))\n (:hscopes ((:id . :x470.9.1) (:span 0 88)))\n (:identifiers (:sid . :s470.9) (:did . :|97107281|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004341@unknown@formal@none@1@S@[ Cortisone-resistant bronchial asthma ]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cortisone-resistant")\n  (:form . "Cortisone-resistant") (:end . 21) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 31)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 38)\n  (:start . 32) (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 40) (:start . 39)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s471.1) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004342@unknown@formal@none@1@S@There is general agreement on the inflammatory pathogenesis of bronchial asthma:@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s471.2) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004343@unknown@formal@none@1@S@an accumulation of activated eosinophils, degranulated mast cells, T lymphocytes and in very severe forms, granulocytes has constantly been found in the bronchial mucosa.@(((:tag . "DT") (:stem . "an") (:form . "an") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "degranulate") (:form . "degranulated") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "RB") (:stem . "constantly") (:form . "constantly") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 162)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "mucosa") (:form . "mucosa") (:end . 169)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s471.3) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004344@unknown@formal@none@1@S@In allergic bronchial asthma, inflammation seems to be orchestrated predominantly by a subset of T lymphocytes, with a phenotype similar to the Th2 subset able to produce IL-4 and IL-5.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "orchestrate") (:form . "orchestrated") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 154)\n  (:start . 148) (:id . 67))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 170)\n  (:start . 163) (:id . 70))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 184) (:start . 180)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x471.4.1) (:span 43 48)))\n (:hscopes ((:id . :x471.4.1) (:span 30 184)))\n (:identifiers (:sid . :s471.4) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004345@unknown@formal@none@1@S@Although corticosteroids are the most potent therapeutic agents used for this disease, their anti-inflammatory effect differs from patient to patient.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 92)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 110) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s471.5) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004346@unknown@formal@none@1@S@Some criteria which can be used to define steroid-resistant bronchial asthma are listed here.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "steroid-resistant") (:form . "steroid-resistant")\n  (:end . 59) (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "list") (:form . "listed") (:end . 87) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s471.6) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004347@unknown@formal@none@1@S@This review analyzes various molecular alterations responsible for the deficient response to corticosteroid treatment observed in steroid-resistant bronchial asthmatic subjects.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "analyze") (:form . "analyzes") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 107) (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 117)\n  (:start . 108) (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 126)\n  (:start . 118) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "steroid-resistant") (:form . "steroid-resistant")\n  (:end . 147) (:start . 130) (:id . 58))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 157)\n  (:start . 148) (:id . 59))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 167)\n  (:start . 158) (:id . 60))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 176)\n  (:start . 168) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s471.7) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004348@unknown@formal@none@1@S@New knowledge on the mechanism of steroid resistance may have important implications for the treatment of chronic asthma and other diseases.@(((:tag . "JJ") (:stem . "new") (:form . "New") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x471.8.1) (:span 53 56)))\n (:hscopes ((:id . :x471.8.1) (:span 53 139)))\n (:identifiers (:sid . :s471.8) (:did . :|97108276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004350@unknown@formal@none@1@S@In this paper we have investigated the role of Egr-1 in B cell growth regulation by examining the gene expression in a panel of B cell lines, including both EBV genome negative and EBV carrying cell lines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 80)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "examine") (:form . "examining") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 151)\n  (:start . 142) (:id . 70))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 156) (:start . 152)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 160) (:start . 157)\n  (:id . 72))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 167)\n  (:start . 161) (:id . 73))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 176)\n  (:start . 168) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 184) (:start . 181)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 193)\n  (:start . 185) (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 198) (:start . 194)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 204)\n  (:start . 199) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s472.2) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004351@unknown@formal@none@1@S@Egr-1 expression correlates with the cellular phenotype and the specific pattern of viral latency established within the individual cell lines.@(((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s472.3) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004352@unknown@formal@none@1@S@Thus, constitutive activation of Egr-1 gene is invariably associated with unrestricted expression of viral latent genes in all group III EBV genome carrying cell lines.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 18)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "invariably") (:form . "invariably") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unrestricted") (:form . "unrestricted") (:end . 86)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s472.4) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004353@unknown@formal@none@1@S@In contrast, Egr-1 expression is abrogated in group I Burkitt tumor cells, irrespective of the EBV genome carrying status.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "irrespective") (:form . "irrespective") (:end . 87)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s472.5) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004354@unknown@formal@none@1@S@Activated viral gene expression associated with phenotypic conversion of group I cell lines in to group II or III restores the Egr-1 gene expression.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "restore") (:form . "restores") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s472.6) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004355@unknown@formal@none@1@S@Several forms of EGR-1 protein are found within the different groups of cell lines, and the binding activity to DNA consensus sequences was investigated.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 152)\n  (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s472.7) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004356@unknown@formal@none@1@S@Finally, time course analysis of Egr-1 expression during the early steps of EBV infection in vitro demonstrated that Egr-1 is upregulated within minutes from the initial interaction with the B lymphocyte.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 111)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 144)\n  (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 157) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 181)\n  (:start . 170) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 203)\n  (:start . 193) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s472.8) (:did . :|97108656|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004357@unknown@formal@none@1@S@The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 55) (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s473.1) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004358@unknown@formal@none@1@S@Interferon-gamma (IFN-gamma) is produced by natural killer cells and certain subsets of T cells, but the basis for its selective expression is unknown.@(((:tag . "NNP") (:stem . "Interferon-gamma") (:form . "Interferon-gamma")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 150)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s473.2) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004360@unknown@formal@none@1@S@This report describes studies indicating that the most proximal of these two regulatory elements is an important determinant of its restricted expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x473.4.1) (:span 30 45)))\n (:hscopes ((:id . :x473.4.1) (:span 30 153)))\n (:identifiers (:sid . :s473.4) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004361@unknown@formal@none@1@S@The proximal element is a composite site that binds members of the CREB/ATF, AP-1, and octamer families of transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s473.5) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004362@unknown@formal@none@1@S@Jun is essential for activation-induced transcription and binds preferably as a heterodimer with ATF-2.@(((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 39) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "RB") (:stem . "preferably") (:form . "preferably") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 91)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "atf-2") (:form . "ATF-2") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s473.6) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004363@unknown@formal@none@1@S@In contrast, CREB appears to dampen transcription from this element.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "dampen") (:form . "dampen") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x473.7.1) (:span 18 25)))\n (:hscopes ((:id . :x473.7.1) (:span 13 67)))\n (:identifiers (:sid . :s473.7) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004364@unknown@formal@none@1@S@The CpG dinucleotide in this element is selectively methylated in Th2 T cells and other cells that do not express IFN-gamma, and methylation markedly reduces transcription factor binding.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CpG") (:form . "CpG") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dinucleotide") (:form . "dinucleotide") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "methylate") (:form . "methylated") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 123)\n  (:start . 114) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 140)\n  (:start . 129) (:id . 65))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 171) (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 178)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 186)\n  (:start . 179) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x473.8.1) (:span 102 105)))\n (:nscopes ((:id . :x473.8.1) (:span 102 123)))\n (:identifiers (:sid . :s473.8) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004365@unknown@formal@none@1@S@As a target for DNA methylation and for binding of transcription factors that mediate or impede transcription, this element appears to play a central role in controlling IFN-gamma expression.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "impede") (:form . "impede") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 169)\n  (:start . 158) (:id . 69))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 190)\n  (:start . 180) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x473.9.1) (:span 124 131)))\n (:hscopes ((:id . :x473.9.1) (:span 111 190)))\n (:identifiers (:sid . :s473.9) (:did . :|97112990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004366@unknown@formal@none@1@S@Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Raf") (:form . "Raf") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s474.1) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004367@unknown@formal@none@1@S@Functional synergy between Raf and calcineurin.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "NNP") (:stem . "Raf") (:form . "Raf") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s474.2) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004368@unknown@formal@none@1@S@Signals transduced via the TCR activate the transcription factor nuclear factor-kappaB (NF-kappaB), which, in turn, is critical to the transcriptional induction of many genes important for the proliferation and expression of a differentiated phenotype.@(((:tag . "NNS") (:stem . "signal") (:form . "Signals") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 86) (:start . 73) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 150) (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 70))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 184)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 206) (:start . 193) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 226) (:start . 225)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 241) (:start . 227) (:id . 79))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 251)\n  (:start . 242) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s474.3) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004370@unknown@formal@none@1@S@Here we identify intracellular signaling components involved in activation of NF-kappaB following TCR stimulation.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 97)\n  (:start . 88) (:id . 53))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 113)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s474.5) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004371@unknown@formal@none@1@S@TCR signaling was triggered by treating Jurkat T cells with PHA or anti-CD3 Abs, and NF-kappaB activation was monitored by electrophoretic mobility shift assays and/or by kappaB-dependent reporter assays.@(((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "treat") (:form . "treating") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "monitor") (:form . "monitored") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 138) (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 160)\n  (:start . 154) (:id . 66))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 167)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 187) (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 203)\n  (:start . 197) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s474.6) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004372@unknown@formal@none@1@S@Contrary to the idea that protein kinase C is involved in TCR-mediated activation of NF-kappaB, high doses of staurosporine did not interfere with activation of NF-kappaB by PHA, while the same dose of staurosporine completely blocked activation by PMA.@(((:tag . "JJ") (:stem . "contrary") (:form . "Contrary") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "staurosporine") (:form . "staurosporine")\n  (:end . 123) (:start . 110) (:id . 61))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "VB") (:stem . "interfere") (:form . "interfere") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 157)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 177) (:start . 174)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 198) (:start . 194)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 76))\n ((:tag . "NN") (:stem . "staurosporine") (:form . "staurosporine")\n  (:end . 215) (:start . 202) (:id . 77))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 226)\n  (:start . 216) (:id . 78))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 234)\n  (:start . 227) (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 245)\n  (:start . 235) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 248) (:start . 246)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 252) (:start . 249)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x474.7.1) (:span 128 131)))\n (:nscopes ((:id . :x474.7.1) (:span 128 177)))\n (:identifiers (:sid . :s474.7) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004373@unknown@formal@none@1@S@PHA-induced kappaB-dependent reporter activity was , however, effectively blocked by a dominant negative form of Raf-1, suggesting a critical role for a Raf kinase.@(((:tag . "JJ") (:stem . "pha-induced") (:form . "PHA-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 28) (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 37)\n  (:start . 29) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Raf") (:form . "Raf") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x474.8.1) (:span 120 130)))\n (:hscopes ((:id . :x474.8.1) (:span 120 163)))\n (:identifiers (:sid . :s474.8) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004374@unknown@formal@none@1@S@The TCR-mediated activation of NF-kappaB was also dependent on a Ca2+ influx, because the Ca2+ channel blocker, SK&F 96365, as well as other agents that prevented the Ca2+ influx, inhibited NF-kappaB activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "channel") (:form . "channel") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "blocker") (:form . "blocker") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "SK&F") (:form . "SK&F") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "CD") (:stem . "96365") (:form . "96365") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 147)\n  (:start . 141) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 162)\n  (:start . 153) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 178)\n  (:start . 172) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 189)\n  (:start . 180) (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 199)\n  (:start . 190) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 210)\n  (:start . 200) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s474.9) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004375@unknown@formal@none@1@S@Cotransfection of a constitutively active form of calcineurin largely substituted for the Ca2+ requirement and reversed the blockade by SK&F 96365.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "VBN") (:stem . "substitute") (:form . "substituted") (:end . 81)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 106)\n  (:start . 95) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "reverse") (:form . "reversed") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "SK&F") (:form . "SK&F") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "CD") (:stem . "96365") (:form . "96365") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s474.10) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004376@unknown@formal@none@1@S@Consistent with these observations, coexpression of constitutively active forms of Raf-1 and calcineurin synergistically induced kappaB-dependent reporter activity, suggesting a physiologically relevant functional interaction between the kinase and the phosphatase.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 66) (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 120) (:start . 105) (:id . 56))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 145) (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 154)\n  (:start . 146) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 163)\n  (:start . 155) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 175)\n  (:start . 165) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 63))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 193) (:start . 178) (:id . 64))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 202)\n  (:start . 194) (:id . 65))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 213)\n  (:start . 203) (:id . 66))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 225)\n  (:start . 214) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 233)\n  (:start . 226) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 244)\n  (:start . 238) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 248) (:start . 245)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 252) (:start . 249)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 264)\n  (:start . 253) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x474.11.1) (:span 165 175)))\n (:hscopes ((:id . :x474.11.1) (:span 165 264)))\n (:identifiers (:sid . :s474.11) (:did . :|97113313|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004377@unknown@formal@none@1@S@Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2 [published erratum appears in J Immunol 1999 Jul 15;163 ( 2 ):1091]@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "ms-2") (:form . "MS-2") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Immunol") (:form . "Immunol") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Jul") (:form . "Jul") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "CD") (:stem . "15;163") (:form . "15;163") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "CD") (:stem . "):1091") (:form . "):1091") (:end . 181)\n  (:start . 175) (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 182) (:start . 181)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s475.1) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004378@unknown@formal@none@1@S@The differentiation of myeloid precursors into mature myelomonocytic cells is characterized by the induction of the gene encoding the beta2 integrin CD11b.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 68) (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 91) (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "beta2") (:form . "beta2") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 148)\n  (:start . 140) (:id . 62))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s475.2) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004380@unknown@formal@none@1@S@In addition to the CD11b gene, the homologous genes encoding CD11a and CD11c also exhibit inducible expression during myeloid differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNP") (:stem . "CD11a") (:form . "CD11a") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD11c") (:form . "CD11c") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 141) (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s475.4) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004381@unknown@formal@none@1@S@Therefore, we compared the nucleotide sequences of the CD11a, CD11b, and CD11c gene promoters to identify common elements that might contribute to inducible expression.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD11a") (:form . "CD11a") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD11c") (:form . "CD11c") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 156)\n  (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 167)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x475.5.1) (:span 127 132)))\n (:hscopes ((:id . :x475.5.1) (:span 127 167)))\n (:identifiers (:sid . :s475.5) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004382@unknown@formal@none@1@S@This analysis identified one such element repeated four times within the CD11b promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s475.6) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004383@unknown@formal@none@1@S@Mutation of these elements indicated that two, MS-2beta and MS-2gamma, are critical to the induction of the CD11b gene during differentiation of the pro-monocytic cell line U937.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MS-2beta") (:form . "MS-2beta") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MS-2gamma") (:form . "MS-2gamma") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 141) (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "pro-monocytic") (:form . "pro-monocytic")\n  (:end . 162) (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 177) (:start . 173)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x475.7.1) (:span 27 41)))\n (:hscopes ((:id . :x475.7.1) (:span 27 177)))\n (:identifiers (:sid . :s475.7) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004384@unknown@formal@none@1@S@Electrophoretic mobility shift assays indicate that MS-2beta and MS-2gamma interact with nuclear factors that are induced during U937 differentiation.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MS-2beta") (:form . "MS-2beta") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MS-2gamma") (:form . "MS-2gamma") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 104)\n  (:start . 97) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 121)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 128)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 149) (:start . 134) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x475.8.1) (:span 38 51)))\n (:hscopes ((:id . :x475.8.1) (:span 38 149)))\n (:identifiers (:sid . :s475.8) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004385@unknown@formal@none@1@S@These factors are detected at the time the CD11b promoter is activated.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s475.9) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004386@unknown@formal@none@1@S@The molecular mass of these factors is approximately 28 kDa, and their DNA binding characteristics are indistinguishable from those of the novel nuclear factor MS-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 70)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 98) (:start . 83) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 120) (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 159)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "ms-2") (:form . "MS-2") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s475.10) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004387@unknown@formal@none@1@S@Taken together, our data indicate that MS-2 mediates induction of the CD11b gene as cells of the monocytic lineage mature.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ms-2") (:form . "MS-2") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x475.11.1) (:span 25 38)))\n (:hscopes ((:id . :x475.11.1) (:span 25 121)))\n (:identifiers (:sid . :s475.11) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004388@unknown@formal@none@1@S@The presence of multiple potential binding sites for MS-2 in the promoter regions of a wide range of genes expressed in mature myeloid cells suggests this factor plays a general role in myeloid differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ms-2") (:form . "MS-2") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 167)\n  (:start . 162) (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 177)\n  (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 182) (:start . 178)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 193)\n  (:start . 186) (:id . 74))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 209) (:start . 194) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x475.12.1) (:span 141 149)))\n (:hscopes ((:id . :x475.12.1) (:span 141 209)))\n (:identifiers (:sid . :s475.12) (:did . :|97113352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004390@unknown@formal@none@1@S@CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1.@(((:tag . "JJ") (:stem . "cd40-stimulated") (:form . "CD40-stimulated")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 21) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 113) (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s476.2) (:did . :|97115684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004391@unknown@formal@none@1@S@In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 107) (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 150)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s476.3) (:did . :|97115684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004392@unknown@formal@none@1@S@Transient expression assays with plasmids containing deleted parts of the LTR region linked to a reporter gene showed that the NF-kappaB binding site was essential for HIV-1 LTR activity in CD40-stimulated B lymphocytes.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 66) (:start . 61)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 91) (:start . 85)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 163)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cd40-stimulated") (:form . "CD40-stimulated")\n  (:end . 205) (:start . 190) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 207) (:start . 206)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 219)\n  (:start . 208) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s476.4) (:did . :|97115684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004393@unknown@formal@none@1@S@In addition, electrophoretic mobility shift and supershift assays revealed that important NF-kappaB binding activity composed of at least p50, p65, and c-Rel NF-kappaB subunits was present in nuclei of CD40-stimulated B cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 56))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 188)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 198)\n  (:start . 192) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cd40-stimulated") (:form . "CD40-stimulated")\n  (:end . 217) (:start . 202) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 219) (:start . 218)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s476.5) (:did . :|97115684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004394@unknown@formal@none@1@S@These results confirm at a molecular level the ability of HIV-1 to replicate in B cells and that this activity is strongly associated with NF-kappaB.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "confirm") (:form . "confirm") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s476.6) (:did . :|97115684|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004395@unknown@formal@none@1@S@Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "tyrosine") (:form . "tyrosines") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "CD") (:stem . "492/493") (:form . "492/493") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s477.1) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004396@unknown@formal@none@1@S@The protein-tyrosine kinase ZAP-70 is implicated, together with the Src kinase p56(lck), in controlling the early steps of the T-cell antigen receptor (TCR) signaling cascade.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Src") (:form . "Src") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 174)\n  (:start . 167) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s477.2) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004397@unknown@formal@none@1@S@To help elucidate further the mechanism by which ZAP-70 regulates these initial events, we used a dominant-negative mutant approach.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 115) (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s477.3) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004398@unknown@formal@none@1@S@We overexpressed in the Jurkat T-cell line ZAP-70 mutated on Tyr-492 and Tyr-493 in the putative regulatory loop of its kinase domain.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "zap-70") (:form . "ZAP-70") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tyr-492") (:form . "Tyr-492") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tyr-493") (:form . "Tyr-493") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x477.4.1) (:span 88 96)))\n (:hscopes ((:id . :x477.4.1) (:span 88 133)))\n (:identifiers (:sid . :s477.4) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004400@unknown@formal@none@1@S@Moreover, TCR-induced phosphorylation of pp36-38, thought to play a role upstream of these pathways, was found to be reduced.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "tcr-induced") (:form . "TCR-induced") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 37) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pp36-38") (:form . "pp36-38") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s477.6) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004401@unknown@formal@none@1@S@In contrast, overexpression of wild-type ZAP-70 induced constitutive activation of nuclear factor of activated T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "zap-70") (:form . "ZAP-70") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s477.7) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004402@unknown@formal@none@1@S@The ZAP-70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p56(lck).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "zap-70") (:form . "ZAP-70") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 54) (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s477.8) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004403@unknown@formal@none@1@S@This result demonstrates that Tyr-492 and Tyr-493 are not responsible for the Src homology domain 2-mediated association of p56(lck) with ZAP-70.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tyr-492") (:form . "Tyr-492") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tyr-493") (:form . "Tyr-493") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Src") (:form . "Src") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "JJ") (:stem . "2-mediated") (:form . "2-mediated") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 120)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x477.9.1) (:span 54 57)))\n (:nscopes ((:id . :x477.9.1) (:span 54 144)))\n (:identifiers (:sid . :s477.9) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004404@unknown@formal@none@1@S@Our data are most consistent with a model in which recruitment to the TCR allows ZAP-70 autophosphorylation and binding to p56(lck), which in turn phosphorylates Tyr-492 and/or Tyr-493 with consequent up-regulation of the ZAP-70 kinase activity.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "zap-70") (:form . "ZAP-70") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "autophosphorylation")\n  (:form . "autophosphorylation") (:end . 107) (:start . 88) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "phosphorylate") (:form . "phosphorylates")\n  (:end . 161) (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "tyr-492") (:form . "Tyr-492") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "tyr-493") (:form . "Tyr-493") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "consequent") (:form . "consequent") (:end . 200)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 214) (:start . 201) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 228)\n  (:start . 222) (:id . 76))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 235)\n  (:start . 229) (:id . 77))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 244)\n  (:start . 236) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s477.10) (:did . :|97115792|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5004406@unknown@formal@none@1@S@Dexamethasone suppression test: corticosteroid receptors regulation in mononuclear leukocytes of young and aged subjects.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 30) (:start . 26)\n  (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 46) (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 56)\n  (:start . 47) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 67)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 82)\n  (:start . 71) (:id . 50))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 93)\n  (:start . 83) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 102) (:start . 97)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 111) (:start . 107)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 120)\n  (:start . 112) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s478.1) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004407@unknown@formal@none@1@S@The dexamethasone suppression test (DST) is considered an indicator of the function of the adrenal pituitary axis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DST") (:form . "DST") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "indicator") (:form . "indicator") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "axis") (:form . "axis") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x478.2.1) (:span 44 54)))\n (:hscopes ((:id . :x478.2.1) (:span 0 113)))\n (:identifiers (:sid . :s478.2) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004408@unknown@formal@none@1@S@The effect of the steroid is mediated by its binding to corticosteroid receptors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 70) (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s478.3) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004410@unknown@formal@none@1@S@In the present study, corticosteroid Type I and Type II receptors in mononuclear leukocytes were measured in 10 elderly subjects and in 9 young adults, before and after overnight DST (1 mg).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "corticosteroid") (:form . "corticosteroid")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 150)\n  (:start . 144) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 158)\n  (:start . 152) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "JJ") (:stem . "overnight") (:form . "overnight") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "dst") (:form . "DST") (:end . 182) (:start . 179)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 74))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "NN") (:stem . "mg") (:form . "mg") (:end . 188) (:start . 186)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s478.5) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004411@unknown@formal@none@1@S@Receptors were measured by radioreceptor assay.@(((:tag . "NNS") (:stem . "receptor") (:form . "Receptors") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "radioreceptor") (:form . "radioreceptor")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s478.6) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004412@unknown@formal@none@1@S@In all the subjects, dexamethasone was able to suppress plasma cortisol.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s478.7) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004413@unknown@formal@none@1@S@The number of Type I and Type II receptors before the test was lower in elderly subjects than in adults.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 79)\n  (:start . 72) (:id . 57))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 103)\n  (:start . 97) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s478.8) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004414@unknown@formal@none@1@S@In the control group, dexamethasone produced a significant depression of Type I receptors (from 267 ± 72 to 169 ± 71 receptors per cell) , which can be interpreted as a primary involvement of Type I receptors in the response to dexamethasone;@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "depression") (:form . "depression") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "267") (:form . "267") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "±") (:form . "±") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "CD") (:stem . "169") (:form . "169") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "CD") (:stem . "71") (:form . "71") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 126)\n  (:start . 117) (:id . 65))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 70))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 148) (:start . 145)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 151) (:start . 149)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "interpret") (:form . "interpreted") (:end . 163)\n  (:start . 152) (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 176)\n  (:start . 169) (:id . 76))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 188)\n  (:start . 177) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 196) (:start . 192)\n  (:id . 79))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 198) (:start . 197)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 208)\n  (:start . 199) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 83))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 224)\n  (:start . 216) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 227) (:start . 225)\n  (:id . 85))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 241) (:start . 228) (:id . 86))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 242) (:start . 241)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s478.9) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004415@unknown@formal@none@1@S@Type II receptors decreased in half the subjects (from 2849 ± 703 to 2345 ± 569 receptors per cell).@(((:tag . "NN") (:stem . "type") (:form . "Type") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "PDT") (:stem . "half") (:form . "half") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2849") (:form . "2849") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "±") (:form . "±") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "703") (:form . "703") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2345") (:form . "2345") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "CD") (:stem . "569") (:form . "569") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 89)\n  (:start . 80) (:id . 59))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s478.10) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004416@unknown@formal@none@1@S@In elderly healthy subjects, Type II receptors were also significantly decreased (from 1796 ± 671 to 720 ± 345).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1796") (:form . "1796") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "±") (:form . "±") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "CD") (:stem . "671") (:form . "671") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "CD") (:stem . "720") (:form . "720") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "CD") (:stem . "345") (:form . "345") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s478.11) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004417@unknown@formal@none@1@S@We suggest that in young subjects Type II receptors are initially up-regulated by dexamethasone, and then down-regulated, while in aged subjects an up-regulation cannot be achieved, as suggested by the higher values of plasma cortisol usually found in aging subjects.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "initially") (:form . "initially") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 78)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 120) (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "aged") (:form . "aged") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 161) (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 180)\n  (:start . 172) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 194)\n  (:start . 185) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 208)\n  (:start . 202) (:id . 75))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 215)\n  (:start . 209) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 225)\n  (:start . 219) (:id . 78))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 234)\n  (:start . 226) (:id . 79))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 242)\n  (:start . 235) (:id . 80))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 248)\n  (:start . 243) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 251) (:start . 249)\n  (:id . 82))\n ((:tag . "VBG") (:stem . "age") (:form . "aging") (:end . 257) (:start . 252)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 266)\n  (:start . 258) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x478.12.1) (:span 185 194))\n  ((:id . :x478.12.3) (:span 3 10)))\n (:ncues ((:id . :x478.12.2) (:span 162 168)))\n (:hscopes ((:id . :x478.12.1) (:span 182 266))\n  ((:id . :x478.12.3) (:span 3 266)))\n (:nscopes ((:id . :x478.12.2) (:span 128 180)))\n (:identifiers (:sid . :s478.12) (:did . :|97118356|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004418@unknown@formal@none@1@S@Lymphocytes from CML patients lack a 47 kDa factor having affinity for a genomic sterol regulatory sequence.@(((:tag . "NNP") (:stem . "Lymphocyte") (:form . "Lymphocytes") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 57) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "sterol") (:form . "sterol") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x479.1.1) (:span 30 34)))\n (:nscopes ((:id . :x479.1.1) (:span 30 107)))\n (:identifiers (:sid . :s479.1) (:did . :|97119289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004420@unknown@formal@none@1@S@Since the human genomic sterol regulatory element (SRE) has been shown to regulate various key genes involved in this phenomenon, the present study revealed the existence of a unique 47 kDa protein factor having affinity for this SRE sequence in lymphocytes from normal subjects, as well as its absence in lymphocytes from untreated CML patients.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "sterol") (:form . "sterol") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . 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5004421@unknown@formal@none@1@S@However, this factor appeared when these CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBD") (:stem . "achieve") (:form . "achieved") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "haematological") (:form . "haematological")\n  (:end . 86) (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "remission") (:form . "remission") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CHR") (:form . "CHR") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "alpha-interferon") (:form . "alpha-interferon")\n  (:end . 127) (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s479.4) (:did . :|97119289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004422@unknown@formal@none@1@S@Furthermore, an inverse relationship was also observed between the LDL receptor gene expression at the transcriptional level and the binding affinity of this 47 kDa protein factor to the SRE sequence.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 118) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 179)\n  (:start . 173) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 199)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s479.5) (:did . :|97119289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004423@unknown@formal@none@1@S@Based upon these results we propose that this factor may have a role in pathophysiology of chronic myeloid leukaemia.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 87) (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x479.6.1) (:span 53 56)) ((:id . :x479.6.2) (:span 28 35)))\n (:hscopes ((:id . :x479.6.1) (:span 53 116))\n  ((:id . :x479.6.2) (:span 28 116)))\n (:identifiers (:sid . :s479.6) (:did . :|97119289|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004424@unknown@formal@none@1@S@Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types.@(((:tag . "JJ") (:stem . "synergistic") (:form . "Synergistic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 44)\n  (:start . 33) (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 58) (:start . 53)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "elk-1") (:form . "ELK-1") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 115)\n  (:start . 108) (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 150)\n  (:start . 143) (:id . 61))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 156)\n  (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 171) (:start . 157) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "primate") (:form . "primate") (:end . 182)\n  (:start . 175) (:id . 65))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 198) (:start . 183) (:id . 66))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 204)\n  (:start . 199) (:id . 67))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 220) (:start . 205) (:id . 68))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 230)\n  (:start . 221) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 70))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 242)\n  (:start . 234) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 246) (:start . 243)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 259) (:start . 247) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 264) (:start . 260)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 270)\n  (:start . 265) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s480.1) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004425@unknown@formal@none@1@S@Cytomegalovirus (CMV) infection is nonpermissive or persistent in many lymphoid and myeloid cell types but can be activated in differentiated macrophages.@(((:tag . "NNP") (:stem . "Cytomegalovirus") (:form . "Cytomegalovirus")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nonpermissive") (:form . "nonpermissive")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 141) (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 153)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s480.2) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004426@unknown@formal@none@1@S@We have shown elsewhere that both the major immediate-early gene (MIE) and lytic cycle infectious progeny virus expression can be induced in otherwise nonpermissive monocyte-like U-937 cell cultures infected with either human CMV (HCMV) or simian CMV (SCMV) by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "elsewhere") (:form . "elsewhere") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"monocyte-like")\n  (:end . 178) (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 184)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 198)\n  (:start . 190) (:id . 71))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 207)\n  (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 212) (:start . 208)\n  (:id . 73))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 219)\n  (:start . 213) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 225)\n  (:start . 220) (:id . 75))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 229) (:start . 226)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "HCMV") (:form . 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"DT") (:stem . "the") (:form . "the") (:end . 279) (:start . 276)\n  (:id . 89))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 287)\n  (:start . 280) (:id . 90))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 293)\n  (:start . 288) (:id . 91))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 330) (:start . 294)\n  (:id . 92))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 332) (:start . 331)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 335) (:start . 332)\n  (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 336) (:start . 335)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 337) (:start . 336)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s480.3) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004427@unknown@formal@none@1@S@Two multicopy basal enhancer motifs within the SCMV MIE enhancer, namely , 11 copies of the 16-bp cyclic AMP response element (CRE) and 3 copies of novel 17-bp serum response factor (SRF) binding sites referred to as the SNE (SRF/NFkappaB-like element), as well as four classical NFkappaB sites within the HCMV version, contribute to TPA responsiveness in transient assays in monocyte and T-cell types.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "multicopy") (:form . "multicopy") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "within") (:form . 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"element") (:end . 251)\n  (:start . 244) (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 252) (:start . 251)\n  (:id . 89))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 253) (:start . 252)\n  (:id . 90))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 256) (:start . 254)\n  (:id . 91))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 261) (:start . 257)\n  (:id . 92))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 264) (:start . 262)\n  (:id . 93))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 269) (:start . 265)\n  (:id . 94))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 279)\n  (:start . 270) (:id . 95))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 288)\n  (:start . 280) (:id . 96))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 294)\n  (:start . 289) (:id . 97))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 301)\n  (:start . 295) (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 305) (:start . 302)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 310) (:start . 306)\n  (:id . 100))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 318)\n  (:start . 311) (:id . 101))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 319) (:start . 318)\n  (:id . 102))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 330)\n  (:start . 320) (:id . 103))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 333) (:start . 331)\n  (:id . 104))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 337) (:start . 334)\n  (:id . 105))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 352) (:start . 338) (:id . 106))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 355) (:start . 353)\n  (:id . 107))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 365)\n  (:start . 356) (:id . 108))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 372)\n  (:start . 366) (:id . 109))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 375) (:start . 373)\n  (:id . 110))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 384)\n  (:start . 376) (:id . 111))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 388) (:start . 385)\n  (:id . 112))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 395)\n  (:start . 389) (:id . 113))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 401)\n  (:start . 396) (:id . 114))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 402) (:start . 401)\n  (:id . 115)))@@@1@74@((:identifiers (:sid . :s480.4) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004428@unknown@formal@none@1@S@The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF, Rel/NFkappaB, ETS, and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "SCMV") (:form . "SCMV") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SNE") (:form . "SNE") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Rel/NFkappaB") (:form . "Rel/NFkappaB")\n  (:end . 102) (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "yy1") (:form . "YY1") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 174)\n  (:start . 168) (:id . 70))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 180)\n  (:start . 175) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 189)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 198)\n  (:start . 190) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 205)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 211)\n  (:start . 206) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x480.5.1) (:span 149 153)))\n (:nscopes ((:id . :x480.5.1) (:span 149 211)))\n (:identifiers (:sid . :s480.5) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004430@unknown@formal@none@1@S@Unlike classical NFkappaB sites, neither the SNE nor the SEE motif responded to phosphatase inhibition by okadaic acid.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SNE") (:form . "SNE") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "see") (:form . "SEE") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x480.7.1) (:span 33 40 49 52)))\n (:nscopes ((:id . :x480.7.1) (:span 33 118)))\n (:identifiers (:sid . :s480.7) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004431@unknown@formal@none@1@S@However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 31) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . 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"the") (:end . 286) (:start . 283)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 295)\n  (:start . 287) (:id . 89))\n ((:tag . "NN") (:stem . "srf") (:form . "SRF") (:end . 299) (:start . 296)\n  (:id . 90))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 303) (:start . 300)\n  (:id . 91))\n ((:tag . "NN") (:stem . "elk-1") (:form . "ELK-1") (:end . 309)\n  (:start . 304) (:id . 92))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 318)\n  (:start . 310) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 319) (:start . 318)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s480.8) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004432@unknown@formal@none@1@S@This protein complex was more abundant in U-937, K-562, and HeLa cell extracts than in Raji, HF, BALB/c 3T3, or HL-60 cells, but the binding activity was altered only twofold after TPA treatment.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "U-937") (:form . "U-937") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "K-562") (:form . "K-562") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HF") (:form . "HF") (:end . 95) (:start . 93)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BALB/c") (:form . "BALB/c") (:end . 103)\n  (:start . 97) (:id . 63))\n ((:tag . "NN") (:stem . "3t3") (:form . "3T3") (:end . 107) (:start . 104)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 117)\n  (:start . 112) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 128) (:start . 125)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 71))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 140)\n  (:start . 133) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 149)\n  (:start . 141) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 153) (:start . 150)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 161)\n  (:start . 154) (:id . 75))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 166) (:start . 162)\n  (:id . 76))\n ((:tag . "RB") (:stem . "twofold") (:form . "twofold") (:end . 174)\n  (:start . 167) (:id . 77))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 180)\n  (:start . 175) (:id . 78))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 184) (:start . 181)\n  (:id . 79))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 194)\n  (:start . 185) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s480.9) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004433@unknown@formal@none@1@S@A 40-fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the SNE could be induced within 2 h ( and up to 250-fold within 6 h) after addition of TPA in DNA-transfected U-937 cells, indicating that the stimulation appeared likely to be a true protein kinase C-mediated signal transduction event rather than a differentiation response.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "40-fold") (:form . "40-fold") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . 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"be") (:end . 279) (:start . 277)\n  (:id . 88))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 281) (:start . 280)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 286) (:start . 282)\n  (:id . 90))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 294)\n  (:start . 287) (:id . 91))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 301)\n  (:start . 295) (:id . 92))\n ((:tag . "JJ") (:stem . "c-mediated") (:form . "C-mediated") (:end . 312)\n  (:start . 302) (:id . 93))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 319)\n  (:start . 313) (:id . 94))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 332)\n  (:start . 320) (:id . 95))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 338)\n  (:start . 333) (:id . 96))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 345)\n  (:start . 339) (:id . 97))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 350) (:start . 346)\n  (:id . 98))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 352) (:start . 351)\n  (:id . 99))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 368) (:start . 353) (:id . 100))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 377)\n  (:start . 369) (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 378) (:start . 377)\n  (:id . 102)))@@@1@61@((:hcues ((:id . :x480.10.2) (:span 267 273))\n  ((:id . :x480.10.3) (:span 258 266)) ((:id . :x480.10.4) (:span 226 241)))\n (:ncues ((:id . :x480.10.1) (:span 339 350)))\n (:hscopes ((:id . :x480.10.2) (:span 267 377))\n  ((:id . :x480.10.3) (:span 242 377)) ((:id . :x480.10.4) (:span 226 377)))\n (:nscopes ((:id . :x480.10.1) (:span 339 377)))\n (:identifiers (:sid . :s480.10) (:did . :|97126060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004434@unknown@formal@none@1@S@Slight differences in the sequence of the core SRF binding site compared with that of the classical c-Fos promoter serum response element, together with differences in the spacing between the SRF and ETS motifs, appear to account for the inability of the SCMV SNEs to respond to serum induction.@(((:tag . "JJ") (:stem . "slight") (:form . "Slight") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . 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5004435@unknown@formal@none@1@S@Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-alpha) in human monocytes.@(((:tag . "JJ") (:stem . "acetylsalicylic") (:form . "Acetylsalicylic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 20) (:start . 16)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 71)\n  (:start . 63) (:id . 49))\n ((:tag . "NNP") (:stem . "B/c-Rel") (:form . "B/c-Rel") (:end . 79)\n  (:start . 72) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 101) (:start . 88) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 116)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 126)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 133)\n  (:start . 127) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 148)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 164)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "alfa") (:form . "alfa") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 200)\n  (:start . 191) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s481.1) (:did . :|97127169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004436@unknown@formal@none@1@S@We have investigated the effects of acetylsalicylic acid and sodium salicylate on the LPS-induced synthesis of the pro-coagulant protein tissue factor (TF) and the pro-inflammatory protein tumor necrosis factor-alpha (TNF-alpha), as well as the prostaglandin PGE2 in human monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "acetylsalicylic") (:form . "acetylsalicylic")\n  (:end . 51) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pro-coagulant") (:form . "pro-coagulant")\n  (:end . 128) (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 143)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 150)\n  (:start . 144) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 180) (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 188)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 203)\n  (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 216)\n  (:start . 204) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 218) (:start . 217)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 227)\n  (:start . 218) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 229) (:start . 228)\n  (:id . 76))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 232) (:start . 230)\n  (:id . 77))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 237) (:start . 233)\n  (:id . 78))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 240) (:start . 238)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 80))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 258) (:start . 245) (:id . 81))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 263) (:start . 259)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 266) (:start . 264)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 272)\n  (:start . 267) (:id . 84))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 282)\n  (:start . 273) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s481.2) (:did . :|97127169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004437@unknown@formal@none@1@S@Both drugs dose-dependently inhibited LPS-induced TF and TNF-alpha synthesis at the mRNA and the protein level, and reduced PGE2 production.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 27) (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 49)\n  (:start . 38) (:id . 46))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s481.3) (:did . :|97127169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004438@unknown@formal@none@1@S@As evidenced by electro mobility shift assay (EMSA) and the use of a NF-kappa B prototypic probe, these drugs probably exert their inhibitory effects by interference with the nuclear translocation of NF-kappa B/c-Rel proteins.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "electro") (:form . "electro") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 77)\n  (:start . 69) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "prototypic") (:form . "prototypic") (:end . 90)\n  (:start . 80) (:id . 59))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 96) (:start . 91)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 109)\n  (:start . 104) (:id . 63))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 118)\n  (:start . 110) (:id . 64))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 130)\n  (:start . 125) (:id . 66))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 141)\n  (:start . 131) (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 149)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 165)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 182)\n  (:start . 175) (:id . 73))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 196) (:start . 183) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 208)\n  (:start . 200) (:id . 76))\n ((:tag . "NNP") (:stem . "B/c-Rel") (:form . "B/c-Rel") (:end . 216)\n  (:start . 209) (:id . 77))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 225)\n  (:start . 217) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x481.4.1) (:span 110 118)))\n (:hscopes ((:id . :x481.4.1) (:span 110 225)))\n (:identifiers (:sid . :s481.4) (:did . :|97127169|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004440@unknown@formal@none@1@S@Octamer independent activation of transcription from the kappa immunoglobulin germline promoter.@(((:tag . "NNP") (:stem . "Octamer") (:form . "Octamer") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 77) (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 95)\n  (:start . 87) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s482.1) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004441@unknown@formal@none@1@S@Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "v") (:form . "V") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "lead") (:form . "led") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 127)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 160) (:start . 145) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 180) (:start . 165) (:id . 67))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 190)\n  (:start . 181) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 206) (:start . 191) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 217)\n  (:start . 207) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 71))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 235) (:start . 221) (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 241)\n  (:start . 236) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s482.2) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004442@unknown@formal@none@1@S@The germline promoters (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ko") (:form . "Ko") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 98) (:start . 94)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 106)\n  (:start . 99) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 117)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 135)\n  (:start . 125) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 144)\n  (:start . 138) (:id . 68))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 149) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 154) (:start . 150)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 163)\n  (:start . 155) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 176)\n  (:start . 168) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 194)\n  (:start . 187) (:id . 77))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 202)\n  (:start . 195) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 79))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 209)\n  (:start . 204) (:id . 80))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 213) (:start . 210)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 218) (:start . 214)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 224)\n  (:start . 219) (:id . 83))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 235)\n  (:start . 225) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 238) (:start . 236)\n  (:id . 85))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 243) (:start . 239)\n  (:id . 86))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 249)\n  (:start . 244) (:id . 87))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 253) (:start . 250)\n  (:id . 88))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 259)\n  (:start . 254) (:id . 89))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 273) (:start . 260) (:id . 90))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 281)\n  (:start . 274) (:id . 91))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 284) (:start . 282)\n  (:id . 92))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 290)\n  (:start . 285) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 291) (:start . 290)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s482.3) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004443@unknown@formal@none@1@S@To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 125)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "quantitate") (:form . "quantitated") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "relative") (:form . 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"motif") (:end . 294)\n  (:start . 289) (:id . 88))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 297) (:start . 295)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 313) (:start . 298) (:id . 90))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 324)\n  (:start . 314) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 325) (:start . 324)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s482.4) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004444@unknown@formal@none@1@S@We find that , although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . 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"non-octamer") (:end . 224)\n  (:start . 213) (:id . 79))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 230)\n  (:start . 225) (:id . 80))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 234) (:start . 231)\n  (:id . 81))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 244)\n  (:start . 238) (:id . 83))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 247) (:start . 245)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 263) (:start . 248) (:id . 85))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 274)\n  (:start . 264) (:id . 86))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 279) (:start . 275)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 283) (:start . 280)\n  (:id . 88))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 292)\n  (:start . 284) (:id . 89))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 301)\n  (:start . 293) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 91)))@@@1@50@((:ncues ((:id . :x482.5.1) (:span 235 237)))\n (:nscopes ((:id . :x482.5.1) (:span 235 301)))\n (:identifiers (:sid . :s482.5) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004445@unknown@formal@none@1@S@We also find significant differences in activation of germline and V region promoters by kappa enhancers.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "v") (:form . "V") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s482.6) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004446@unknown@formal@none@1@S@Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "v") (:form . "V") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x482.7.1) (:span 12 19)))\n (:hscopes ((:id . :x482.7.1) (:span 12 170)))\n (:identifiers (:sid . :s482.7) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004447@unknown@formal@none@1@S@These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "v-j") (:form . "V-J") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 141) (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s482.8) (:did . :|97128276|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004448@unknown@formal@none@1@S@Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 47) (:start . 31) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 54)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 64)\n  (:start . 55) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 77)\n  (:start . 70) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s483.1) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004450@unknown@formal@none@1@S@p27Kip1 directly inhibits the catalytic activity of cyclin/cdks (cyclin-dependent kinase) complexes and/or interferes physically with cyclin/cdks activation by CAK.@(((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cyclin/cdk") (:form . "cyclin/cdks") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 81) (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 128)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cyclin/cdk") (:form . "cyclin/cdks") (:end . 145)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CAK") (:form . "CAK") (:end . 163) (:start . 160)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s483.3) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004451@unknown@formal@none@1@S@Interestingly, the expression level of p27Kip1 mRNA was maximal in resting Go T-cells and rapidly declined following anti-CD3 activation.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NNP") (:stem . "Go") (:form . "Go") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "VBD") (:stem . "decline") (:form . "declined") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s483.4) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004452@unknown@formal@none@1@S@We report here the cloning of p27Kip1 gene from murine genomic DNA and the functional analysis of the promoter of the p27Kip1 gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s483.5) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004453@unknown@formal@none@1@S@The gene consists of at least three exons and spans more than 5.6 kb of DNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "span") (:form . "spans") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "CD") (:stem . "5.6") (:form . "5.6") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s483.6) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004454@unknown@formal@none@1@S@Primer extension and nuclease S1 protection analysis revealed two major transcription initiation sites.@(((:tag . "NNP") (:stem . "Primer") (:form . "Primer") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nuclease") (:form . "nuclease") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "s1") (:form . "S1") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s483.7) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004455@unknown@formal@none@1@S@The promoter region lacked a TATA box but contained potential binding sites for the transcriptional factors including two Sp1, CRE, Myb and NFkB located at positions -153, -178, -286, -875, and -1011, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "lack") (:form . "lacked") (:end . 26) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 99) (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Myb") (:form . "Myb") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NFkB") (:form . "NFkB") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . "CD") (:stem . "-153") (:form . "-153") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "CD") (:stem . "-178") (:form . "-178") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "CD") (:stem . "-286") (:form . "-286") (:end . 182) (:start . 178)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 75))\n ((:tag . "CD") (:stem . "-875") (:form . "-875") (:end . 188) (:start . 184)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 78))\n ((:tag . "CD") (:stem . "-1011") (:form . "-1011") (:end . 199)\n  (:start . 194) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 80))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 213)\n  (:start . 201) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x483.8.1) (:span 20 26)))\n (:nscopes ((:id . :x483.8.1) (:span 20 37)))\n (:identifiers (:sid . :s483.8) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004456@unknown@formal@none@1@S@To analyze the regulatory mechanisms controlling p27Kip1 gene expression, we characterized the 5'-flanking region from nt -1609 to +178.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "p27kip1") (:form . "p27Kip1") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 106)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 113)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nt") (:form . "nt") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-1609") (:form . "-1609") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "CD") (:stem . "+178") (:form . "+178") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s483.9) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004457@unknown@formal@none@1@S@The -326 to -615 region contained positive regulatory elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "-326") (:form . "-326") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "-615") (:form . "-615") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s483.10) (:did . :|97128814|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004458@unknown@formal@none@1@S@Glucocorticoid-mediated inhibition of RANTES expression in human T lymphocytes.@(((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "Glucocorticoid-mediated") (:end . 23) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 34)\n  (:start . 24) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 44)\n  (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 78)\n  (:start . 67) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s484.1) (:did . :|97131617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004460@unknown@formal@none@1@S@We observed that dexamethasone dramatically inhibited RANTES mRNA expression dose dependently in anti-CD3 activated Hut-78 T cells and human PBMCs.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 60)\n  (:start . 54) (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "RB") (:stem . "dependently") (:form . "dependently") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 105)\n  (:start . 97) (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 115)\n  (:start . 106) (:id . 55))\n ((:tag . "JJ") (:stem . "hut-78") (:form . "Hut-78") (:end . 122)\n  (:start . 116) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 140)\n  (:start . 135) (:id . 60))\n ((:tag . "NNS") (:stem . "pbmc") (:form . "PBMCs") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s484.3) (:did . :|97131617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004461@unknown@formal@none@1@S@Inhibition of RANTES expression did not appear to be secondary to IL-2 inhibition and required binding to the intracellular glucocorticoid receptor.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 123) (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 138) (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x484.4.2) (:span 40 46)))\n (:ncues ((:id . :x484.4.1) (:span 36 39)))\n (:hscopes ((:id . :x484.4.2) (:span 0 147)))\n (:nscopes ((:id . :x484.4.1) (:span 0 147)))\n (:identifiers (:sid . :s484.4) (:did . :|97131617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004462@unknown@formal@none@1@S@The down-regulation of RANTES expression by glucocorticoids in T cells may directly contribute to the efficacy of these agents in suppressing cellular infiltration and to their anti-inflammatory properties.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 59) (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 141)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 163)\n  (:start . 151) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 194) (:start . 177) (:id . 68))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 205)\n  (:start . 195) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x484.5.1) (:span 71 74)))\n (:hscopes ((:id . :x484.5.1) (:span 71 205)))\n (:identifiers (:sid . :s484.5) (:did . :|97131617|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004463@unknown@formal@none@1@S@A novel SP-1 site in the human interleukin-1 beta promoter confers preferential transcriptional activity in keratinocytes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sp-1") (:form . "SP-1") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 44) (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "preferential") (:form . "preferential") (:end . 79)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 95) (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "keratinocyte") (:form . "keratinocytes")\n  (:end . 121) (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s485.1) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004464@unknown@formal@none@1@S@To investigate the mechanisms of transcriptional activation of interleukin-1beta (IL-1beta) in non-monocytic cells, we constructed a series of reporter plasmids with the bacterial chloramphenicol acetyltransferase gene linked to various parts of the human IL-1beta promoter and performed transient transfection experiments.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 80) (:start . 63) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "non-monocytic") (:form . "non-monocytic")\n  (:end . 108) (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "construct") (:form . "constructed") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 139)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 179)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 195) (:start . 180) (:id . 68))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 213) (:start . 196) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 218) (:start . 214)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 225)\n  (:start . 219) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 228) (:start . 226)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 236)\n  (:start . 229) (:id . 73))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 242)\n  (:start . 237) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 255)\n  (:start . 250) (:id . 77))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 264)\n  (:start . 256) (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 273)\n  (:start . 265) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 277) (:start . 274)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 287)\n  (:start . 278) (:id . 81))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 297)\n  (:start . 288) (:id . 82))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 310)\n  (:start . 298) (:id . 83))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 322)\n  (:start . 311) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 323) (:start . 322)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s485.2) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004465@unknown@formal@none@1@S@We identified a promoter segment that activates transcription most efficiently in keratinocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 49))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "keratinocyte") (:form . "keratinocytes")\n  (:end . 95) (:start . 82) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s485.3) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004466@unknown@formal@none@1@S@Electrophoretic mobility shift assays (EMSA) with a 43-mer oligonucleotide derived from the functionally identified cis-acting element revealed specific complexes.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "43-mer") (:form . "43-mer") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 74) (:start . 59) (:id . 52))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 104)\n  (:start . 92) (:id . 56))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 162)\n  (:start . 153) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s485.4) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004467@unknown@formal@none@1@S@By competition analysis with transcription factor consensus sequence oligonucleotides and by immunosupershift, transcription factor SP-1 or a closely related protein was shown to bind to this regulatory element.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 85) (:start . 69) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunosupershift") (:form . "immunosupershift")\n  (:end . 109) (:start . 93) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 56))\n ((:tag . "NN") (:stem . "sp-1") (:form . "SP-1") (:end . 136) (:start . 132)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 139) (:start . 137)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 59))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 149)\n  (:start . 142) (:id . 60))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 157)\n  (:start . 150) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 165)\n  (:start . 158) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 169) (:start . 166)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 175)\n  (:start . 170) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 65))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 183) (:start . 179)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 191) (:start . 187)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 202)\n  (:start . 192) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 210)\n  (:start . 203) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x485.5.1) (:span 137 139)))\n (:hscopes ((:id . :x485.5.1) (:span 111 165)))\n (:identifiers (:sid . :s485.5) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004468@unknown@formal@none@1@S@The closest match to the known SP-1 consensus sequence within the respective region is a TCCCCTCCCCT motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "close") (:form . "closest") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "match") (:form . "match") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sp-1") (:form . "SP-1") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tcccctcccct") (:form . "TCCCCTCCCCT") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s485.6) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004470@unknown@formal@none@1@S@Likewise, activation of this reporter construct by tumor necrosis factor-alpha depended on the SP-1 site.@(((:tag . "RB") (:stem . "likewise") (:form . "Likewise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 78)\n  (:start . 66) (:id . 52))\n ((:tag . "VBD") (:stem . "depend") (:form . "depended") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sp-1") (:form . "SP-1") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s485.8) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004471@unknown@formal@none@1@S@These observations suggest that a so-far-unrecognized SP-1 site in the human IL-1beta promoter may participate in the transcriptional regulation of this gene in keratinocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "so-far-unrecognized")\n  (:form . "so-far-unrecognized") (:end . 53) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "sp-1") (:form . "SP-1") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 133) (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 144)\n  (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "keratinocyte") (:form . "keratinocytes")\n  (:end . 174) (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x485.9.1) (:span 95 98)) ((:id . :x485.9.2) (:span 19 26)))\n (:hscopes ((:id . :x485.9.1) (:span 95 174))\n  ((:id . :x485.9.2) (:span 19 174)))\n (:identifiers (:sid . :s485.9) (:did . :|97131823|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004472@unknown@formal@none@1@S@Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "steroid-sensitive") (:form . "steroid-sensitive")\n  (:end . 86) (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "steroid-resistant") (:form . "steroid-resistant")\n  (:end . 108) (:start . 91) (:id . 53))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 115)\n  (:start . 109) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s486.1) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004473@unknown@formal@none@1@S@BACKGROUND : Glucocorticoids are important medications used to control the airway inflammation associated with asthma.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 28) (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "medication") (:form . "medications") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "airway") (:form . "airway") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 94)\n  (:start . 82) (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 55))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 117)\n  (:start . 111) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s486.2) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004474@unknown@formal@none@1@S@Synthetic glucocorticoids vary in their binding affinity for the glucocorticoid receptor (GCR).@(((:tag . "JJ") (:stem . "synthetic") (:form . "Synthetic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 25) (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "vary") (:form . "vary") (:end . 30) (:start . 26)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 39)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 79) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s486.3) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004475@unknown@formal@none@1@S@METHODS : We compared hydrocortisone, beclomethasone dipropionate, triamcinolone acetonide, flunisolide, and budesonide with regard to their capacity to inhibit phytohemagglutinin-induced peripheral blood mononuclear cell proliferation from six patients with steroid-sensitive asthma and seven patients with steroid-resistant asthma.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 36) (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beclomethasone") (:form . "beclomethasone")\n  (:end . 52) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "dipropionate") (:form . "dipropionate") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "triamcinolone") (:form . "triamcinolone")\n  (:end . 80) (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "acetonide") (:form . "acetonide") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "flunisolide") (:form . "flunisolide") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "budesonide") (:form . "budesonide") (:end . 119)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 160)\n  (:start . 153) (:id . 64))\n ((:tag . "JJ") (:stem . "phytohemagglutinin-induced")\n  (:form . "phytohemagglutinin-induced") (:end . 187) (:start . 161)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 198)\n  (:start . 188) (:id . 66))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 204)\n  (:start . 199) (:id . 67))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 216)\n  (:start . 205) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 221) (:start . 217)\n  (:id . 69))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 235) (:start . 222) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 240) (:start . 236)\n  (:id . 71))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 244) (:start . 241)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 253)\n  (:start . 245) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 258) (:start . 254)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "steroid-sensitive") (:form . "steroid-sensitive")\n  (:end . 276) (:start . 259) (:id . 75))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 283)\n  (:start . 277) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 287) (:start . 284)\n  (:id . 77))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 293)\n  (:start . 288) (:id . 78))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 302)\n  (:start . 294) (:id . 79))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 307) (:start . 303)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "steroid-resistant") (:form . "steroid-resistant")\n  (:end . 325) (:start . 308) (:id . 81))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 332)\n  (:start . 326) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 333) (:start . 332)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s486.4) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004476@unknown@formal@none@1@S@Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gcr") (:form . "GCR") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "budesonide") (:form . "budesonide") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 110)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 143) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "radioligand") (:form . "radioligand") (:end . 157)\n  (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 165)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Scatchard") (:form . "Scatchard") (:end . 185)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 194)\n  (:start . 186) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s486.5) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004477@unknown@formal@none@1@S@RESULTS : Dose-dependent inhibition was demonstrated for all glucocorticoids in both patient groups, with the steroid-resistant group requiring approximately 2 log-fold more glucocorticoids for an equivalent degree of inhibition.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "Dose-dependent")\n  (:end . 24) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 76) (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 99)\n  (:start . 93) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "steroid-resistant") (:form . "steroid-resistant")\n  (:end . 127) (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 143)\n  (:start . 134) (:id . 60))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 157) (:start . 144) (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 159) (:start . 158)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "log-fold") (:form . "log-fold") (:end . 168)\n  (:start . 160) (:id . 63))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 173) (:start . 169)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 189) (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 193) (:start . 190)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 196) (:start . 194)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 207)\n  (:start . 197) (:id . 68))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 214)\n  (:start . 208) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 70))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 228)\n  (:start . 218) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s486.6) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004478@unknown@formal@none@1@S@The mean concentrations necessary to cause 50 % inhibition of lymphocyte proliferation (IC50s) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone, whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . 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5004480@unknown@formal@none@1@S@Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity.@(((:tag . "NNS") (:stem . "patient") (:form . "Patients") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "steroid-resistant") (:form . "steroid-resistant")\n  (:end . 31) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 38)\n  (:start . 32) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s486.9) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004481@unknown@formal@none@1@S@The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "budesonide") (:form . "budesonide") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 64) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 105)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 152) (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s486.10) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004482@unknown@formal@none@1@S@CONCLUSION : These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "These") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 52) (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "budesonide") (:form . "budesonide") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virtue") (:form . "virtue") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 91)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gcr") (:form . "GCR") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 151)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 162)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 176) (:start . 163) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 205)\n  (:start . 195) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "management") (:form . "management") (:end . 223)\n  (:start . 213) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "difficult-to-control")\n  (:form . "difficult-to-control") (:end . 247) (:start . 227) (:id . 77))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 254)\n  (:start . 248) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x486.11.1) (:span 178 181))\n  ((:id . :x486.11.2) (:span 24 31)))\n (:hscopes ((:id . :x486.11.1) (:span 178 254))\n  ((:id . :x486.11.2) (:span 24 254)))\n (:identifiers (:sid . :s486.11) (:did . :|97132051|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004483@unknown@formal@none@1@S@Involvement of nuclear factor-kappa B activation in IgE synthesis in human B cells.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 35)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s487.1) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004484@unknown@formal@none@1@S@Nuclear factor-kappa B (NF-kappa B) is a transcription factor that binds to the consensus DNA sequence in the cis-acting elements of various genes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s487.2) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004485@unknown@formal@none@1@S@Although NF-kappa B activates the expression of many genes involved in immune and inflammatory responses, little is known about the role of NF-kappa B activation in the induction of IgE synthesis in human B cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 161)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 178)\n  (:start . 169) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 195)\n  (:start . 186) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 204)\n  (:start . 199) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s487.3) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004486@unknown@formal@none@1@S@Therefore we first examined the participation of NF-kappa B in germline C epsilon transcription in a human Burkitt lymphoma B cell line, DND39.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DND39") (:form . "DND39") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s487.4) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004487@unknown@formal@none@1@S@Stimulation of DND39 cells with IL-4 or anti-CD40 monoclonal antibody (mAb) activated phosphatidylinositol 3-kinase and subsequently induced nuclear expression of NF-kappa B, which was identified by electrophoretic mobility shift assays.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DND39") (:form . "DND39") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 106) (:start . 86) (:id . 56))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 132)\n  (:start . 120) (:id . 59))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 140)\n  (:start . 133) (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 148)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 171)\n  (:start . 163) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 173) (:start . 172)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 195)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 198) (:start . 196)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 214) (:start . 199) (:id . 71))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 223)\n  (:start . 215) (:id . 72))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 229)\n  (:start . 224) (:id . 73))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 236)\n  (:start . 230) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s487.5) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004488@unknown@formal@none@1@S@n-Acetyl-L-cysteine (NAC), a potent antioxidant, blocked NF-kappa B activation caused by IL-4 and by anti-CD40 mAb.@(((:tag . "NN") (:stem . "n-acetyl-l-cysteine")\n  (:form . "n-Acetyl-L-cysteine") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 110)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s487.6) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004490@unknown@formal@none@1@S@Second, we studied the effect of NAC on IgE synthesis in human normal B cells costimulated with IL-4 and anti-CD40 mAb.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "costimulate") (:form . "costimulated") (:end . 90)\n  (:start . 78) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 114)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s487.8) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004491@unknown@formal@none@1@S@NAC was effective in inhibiting mature C epsilon transcription and IgE synthesis in the T cell-independent culture system.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cell-independent") (:form . "cell-independent")\n  (:end . 106) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s487.9) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004492@unknown@formal@none@1@S@However, NAC did not significantly affect the spontaneous production of IgE by atopic B cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "spontaneous") (:form . "spontaneous") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s487.10) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004493@unknown@formal@none@1@S@These results indicate that NF-kappa B activity is commonly inducible in DND39 cells by IL-4 and anti-CD40 mAb and suggest that NF-kappa B sensitive to NAC may play a role in regulating IgE synthesis in B cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DND39") (:form . "DND39") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 185)\n  (:start . 175) (:id . 73))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 189) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 199)\n  (:start . 190) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 204) (:start . 203)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 210)\n  (:start . 205) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x487.11.1) (:span 156 159))\n  ((:id . :x487.11.2) (:span 115 122)) ((:id . :x487.11.3) (:span 14 27)))\n (:hscopes ((:id . :x487.11.1) (:span 156 210))\n  ((:id . :x487.11.2) (:span 115 210)) ((:id . :x487.11.3) (:span 14 110)))\n (:identifiers (:sid . :s487.11) (:did . :|97132074|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004494@unknown@formal@none@1@S@[Molecular mechanisms of age-related lymphocyte dysfunction]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 10)\n  (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "dysfunction") (:form . "dysfunction") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 60) (:start . 59)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s488.1) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004495@unknown@formal@none@1@S@Aging is classically accompanied by a dysregulation of the immunologic machinery.@(((:tag . "NN") (:stem . "aging") (:form . "Aging") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "classically") (:form . "classically") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s488.2) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004496@unknown@formal@none@1@S@As a consequence, the immune response developed in senescent organisms is usually inappropriate, often inefficient, sometimes aberrant, and potentially detrimental.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 16)\n  (:start . 5) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "senescent") (:form . "senescent") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "inappropriate") (:form . "inappropriate")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inefficient") (:form . "inefficient") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "RB") (:stem . "sometimes") (:form . "sometimes") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "JJ") (:stem . "detrimental") (:form . "detrimental") (:end . 163)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x488.3.1) (:span 140 151)))\n (:hscopes ((:id . :x488.3.1) (:span 140 163)))\n (:identifiers (:sid . :s488.3) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004497@unknown@formal@none@1@S@The age-associated immune dysfunction may be implicated to some degree in the extreme susceptibility of the elderly to infection and neoplasia and may even participate in various aspects of senescence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "age-associated") (:form . "age-associated")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "dysfunction") (:form . "dysfunction") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "extreme") (:form . "extreme") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 100) (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "neoplasia") (:form . "neoplasia") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 167)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 186)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 70))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 200)\n  (:start . 190) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x488.4.1) (:span 147 150))\n  ((:id . :x488.4.2) (:span 38 41)))\n (:hscopes ((:id . :x488.4.1) (:span 147 200))\n  ((:id . :x488.4.2) (:span 0 142)))\n (:identifiers (:sid . :s488.4) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004498@unknown@formal@none@1@S@The current understanding of the molecular mechanisms underlying immunosenescence is still fragmentary.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "immunosenescence") (:form . "immunosenescence")\n  (:end . 81) (:start . 65) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fragmentary") (:form . "fragmentary") (:end . 102)\n  (:start . 91) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s488.5) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004500@unknown@formal@none@1@S@The loss of proliferative potential in response to antigenic challenge is a characteristic feature of immune senescence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 90) (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s488.7) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004501@unknown@formal@none@1@S@It is directly implicated in the emergence of the age-related immune deficiency.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s488.8) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004502@unknown@formal@none@1@S@The purpose of this review is to show how the accumulation of various biochemical lesions with advancing age leads to the failure of a critical cell function, namely the activation-induced lymphocyte proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 58)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "advance") (:form . "advancing") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 143)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 165)\n  (:start . 159) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 188) (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 199)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 213) (:start . 200) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s488.9) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004503@unknown@formal@none@1@S@The biochemical modifications responsible for the defect in transduction and execution of the proliferative signal are analyzed as a function of age.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 41)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 72)\n  (:start . 60) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "execution") (:form . "execution") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 107) (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 114)\n  (:start . 108) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s488.10) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004504@unknown@formal@none@1@S@The multiple alterations observed on the various biochemical pathways may appear as a consequence of a unique deleterious mechanism more fundamentally related to the process of senescence such as the inability to cope with oxidative stress.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "JJ") (:stem . "deleterious") (:form . "deleterious") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "RB") (:stem . "fundamentally") (:form . "fundamentally")\n  (:end . 150) (:start . 137) (:id . 62))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 187)\n  (:start . 177) (:id . 68))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 192) (:start . 188)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 209)\n  (:start . 200) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 212) (:start . 210)\n  (:id . 73))\n ((:tag . "VB") (:stem . "cope") (:form . "cope") (:end . 217) (:start . 213)\n  (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 222) (:start . 218)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 232)\n  (:start . 223) (:id . 76))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 239)\n  (:start . 233) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x488.11.1) (:span 74 80))\n  ((:id . :x488.11.2) (:span 70 73)))\n (:hscopes ((:id . :x488.11.1) (:span 74 239))\n  ((:id . :x488.11.2) (:span 70 239)))\n (:identifiers (:sid . :s488.11) (:did . :|97132479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004505@unknown@formal@none@1@S@Stimulation of human peripheral blood mononuclear cells by zinc and related cations.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "cation") (:form . "cations") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s489.1) (:did . :|97135341|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004506@unknown@formal@none@1@S@Zinc is an important trace element for immune function.@(((:tag . "NN") (:stem . "zinc") (:form . "Zinc") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s489.2) (:did . :|97135341|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004507@unknown@formal@none@1@S@Here, we show that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . 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5004508@unknown@formal@none@1@S@Structurally related divalent cations like cobalt, nickel, and mercury also partially increase monokine secretion but to a much lower and thus insignificant extent.@(((:tag . "RB") (:stem . "structurally") (:form . "Structurally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "JJ") (:stem . "divalent") (:form . "divalent") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NNS") (:stem . "cation") (:form . "cations") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cobalt") (:form . "cobalt") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nickel") (:form . "nickel") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mercury") (:form . "mercury") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "monokine") (:form . "monokine") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 133) (:start . 128)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "insignificant") (:form . "insignificant")\n  (:end . 156) (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s489.4) (:did . :|97135341|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004510@unknown@formal@none@1@S@Therefore, monokine induction is a zinc-specific effect influenced by the physicochemical properties of the ion.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "monokine") (:form . "monokine") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "zinc-specific") (:form . "zinc-specific")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "physicochemical") (:form . "physicochemical")\n  (:end . 89) (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s489.6) (:did . :|97135341|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004511@unknown@formal@none@1@S@Confirmation of the unique significance of zinc for immune function provides a better understanding of the mechanisms of specific zinc-mediated immune modulation.@(((:tag . "NN") (:stem . "confirmation") (:form . "Confirmation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 85) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 99) (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "JJ") (:stem . "zinc-mediated") (:form . "zinc-mediated")\n  (:end . 143) (:start . 130) (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 150)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s489.7) (:did . :|97135341|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004512@unknown@formal@none@1@S@Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "G0S3") (:form . "G0S3") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s490.1) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004513@unknown@formal@none@1@S@G0S3 is a member of a set of putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from human blood mononuclear cells cultured for 2 hr with lectin and cycloheximide.@(((:tag . "NNP") (:stem . "G0S3") (:form . "G0S3") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 37)\n  (:start . 29) (:id . 50))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "G0S") (:form . "G0S") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 88)\n  (:start . 80) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "screen") (:form . "screening") (:end . 101)\n  (:start . 92) (:id . 61))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "library") (:form . "libraries") (:end . 116)\n  (:start . 107) (:id . 63))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 125)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 154)\n  (:start . 143) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 169)\n  (:start . 161) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 175) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 74))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 190)\n  (:start . 184) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 208) (:start . 195) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x490.2.1) (:span 29 37)))\n (:hscopes ((:id . :x490.2.1) (:span 29 79)))\n (:identifiers (:sid . :s490.2) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004514@unknown@formal@none@1@S@The sequence shows high homology with the murine FOSB gene, which encodes a component of the AP1 transcriptional regulator.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 112) (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s490.3) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004515@unknown@formal@none@1@S@Comparison of cDNA and genomic sequences reveals a 4-exon structure characteristic of the FOS family of genes.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "4-exon") (:form . "4-exon") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 82) (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s490.4) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004516@unknown@formal@none@1@S@Freshly isolated cells show high levels of FOSB/G0S3 and FOS/G0S7 mRNAs, which decline rapidly during incubation in culture medium.@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FOSB/G0S3") (:form . "FOSB/G0S3") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fos/g0s7") (:form . "FOS/G0S7") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "decline") (:form . "decline") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s490.5) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004517@unknown@formal@none@1@S@The kinetics of expression suggest that the high initial levels are caused by the isolation procedure, and do not reflect constitutive expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 134)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x490.6.2) (:span 27 34)))\n (:ncues ((:id . :x490.6.1) (:span 110 113)))\n (:hscopes ((:id . :x490.6.2) (:span 27 145)))\n (:nscopes ((:id . :x490.6.1) (:span 110 145)))\n (:identifiers (:sid . :s490.6) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004518@unknown@formal@none@1@S@In cells preincubated for a day, levels of FOS mRNA reach a maximum 20 min after the addition of lectin and decline to control levels over the next 3 hr.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "reach") (:form . "reach") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 67)\n  (:start . 60) (:id . 55))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 80) (:start . 75)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 93)\n  (:start . 85) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 103)\n  (:start . 97) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "decline") (:form . "decline") (:end . 115)\n  (:start . 108) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 126)\n  (:start . 119) (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 133)\n  (:start . 127) (:id . 67))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 147) (:start . 143)\n  (:id . 70))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 149) (:start . 148)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 152) (:start . 150)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s490.7) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004520@unknown@formal@none@1@S@In freshly isolated cells, both FOS and FOSB mRNAs increase dramatically in response to the protein synthesis inhibitor cycloheximide.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 133) (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s490.9) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004521@unknown@formal@none@1@S@In preincubated cells, the cycloheximide response is decreased, especially in the case of FOSB.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "preincubated") (:form . "preincubated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s490.10) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004522@unknown@formal@none@1@S@These differences in expression of FOS and FOSB suggest different roles and regulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x490.11.1) (:span 48 55)))\n (:hscopes ((:id . :x490.11.1) (:span 48 86)))\n (:identifiers (:sid . :s490.11) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004523@unknown@formal@none@1@S@Regions of low base order-dependent stem-loop potential in the region of the gene are defined.@(((:tag . "NNS") (:stem . "region") (:form . "Regions") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "order-dependent") (:form . "order-dependent")\n  (:end . 35) (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "stem-loop") (:form . "stem-loop") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s490.12) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004524@unknown@formal@none@1@S@These indicate where base order has been adapted for purposes other than stem-loop stability (e.g., encoding proteins or gene regulation).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "adapt") (:form . "adapted") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "purpose") (:form . "purposes") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "stem-loop") (:form . "stem-loop") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 136)\n  (:start . 126) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s490.13) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004525@unknown@formal@none@1@S@Regions of low potential in a 68.5-kb genomic segment containing the FOSB gene suggest that the potential may help locate genes in uncharted DNA sequences.@(((:tag . "NNS") (:stem . "region") (:form . "Regions") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "68.5-kb") (:form . "68.5-kb") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "FOSB") (:form . "FOSB") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "VB") (:stem . "locate") (:form . "locate") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "uncharted") (:form . "uncharted") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 154)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x490.14.1) (:span 106 109))\n  ((:id . :x490.14.2) (:span 79 86)))\n (:hscopes ((:id . :x490.14.1) (:span 106 154))\n  ((:id . :x490.14.2) (:span 79 154)))\n (:identifiers (:sid . :s490.14) (:did . :|97138090|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004526@unknown@formal@none@1@S@Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "jak3-deficient") (:form . "JAK3-deficient")\n  (:end . 45) (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 78) (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 90)\n  (:start . 79) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "jak3-dependent") (:form . "JAK3-dependent")\n  (:end . 106) (:start . 92) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 122)\n  (:start . 111) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 131)\n  (:start . 123) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s491.1) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004527@unknown@formal@none@1@S@Both IL-2 and IL-4 bind to receptors containing the common gamma chain and JAK3.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s491.2) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004528@unknown@formal@none@1@S@Although JAK3 is required for proper lymphoid development, the precise roles of this kinase in IL-2 and IL-4 signaling in lymphocytes have not been defined.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "proper") (:form . "proper") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 133)\n  (:start . 122) (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x491.3.1) (:span 139 142)))\n (:nscopes ((:id . :x491.3.1) (:span 59 155)))\n (:identifiers (:sid . :s491.3) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004530@unknown@formal@none@1@S@Although IL-2-induced phosphorylation of IL-2R beta, JAK1, and STAT5 all required the presence of JAK3, IL-4-mediated phosphorylation of JAK1, STAT6, and insulin receptor substrates 1 and 2 did not.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 37) (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "JAK1") (:form . "JAK1") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "il-4-mediated") (:form . "IL-4-mediated")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 133) (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "JAK1") (:form . "JAK1") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 189) (:start . 188)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x491.5.1) (:span 194 197)))\n (:nscopes ((:id . :x491.5.1) (:span 194 197)))\n (:identifiers (:sid . :s491.5) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004531@unknown@formal@none@1@S@However, IL-4-induced effects were clearly improved following JAK3 expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s491.6) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004532@unknown@formal@none@1@S@These data indicate that IL-4 signaling occurs in the absence of of JAK3, but is comparatively inefficient.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "comparatively") (:form . "comparatively")\n  (:end . 94) (:start . 81) (:id . 58))\n ((:tag . "JJ") (:stem . "inefficient") (:form . "inefficient") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x491.7.1) (:span 11 24)))\n (:hscopes ((:id . :x491.7.1) (:span 11 106)))\n (:identifiers (:sid . :s491.7) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004533@unknown@formal@none@1@S@These findings may help in understanding the pathogenesis of the immunodeficiency that occurs with mutations of JAK3 and may suggest a mechanism for the pleiotropic effects of IL-4.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "understand") (:form . "understanding") (:end . 40)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 81) (:start . 65) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 164)\n  (:start . 153) (:id . 66))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 172)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x491.8.1) (:span 125 132))\n  ((:id . :x491.8.2) (:span 121 124)) ((:id . :x491.8.3) (:span 15 18)))\n (:hscopes ((:id . :x491.8.1) (:span 125 180))\n  ((:id . :x491.8.2) (:span 121 180)) ((:id . :x491.8.3) (:span 15 116)))\n (:identifiers (:sid . :s491.8) (:did . :|97140237|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004534@unknown@formal@none@1@S@Identification of Bcd, a novel proto-oncogene expressed in B-cells.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Bcd") (:form . "Bcd") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 45) (:start . 31) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s492.1) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004535@unknown@formal@none@1@S@A novel B-cell derived (Bcd) oncogene has been isolated from the peripheral blood lymphocytes of one B-cell chronic lymphocytic leukemia (B-CLL) patient using DNA transfer and a mouse tumorigenicity assay.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Bcd") (:form . "Bcd") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 127)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 158) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 183)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "tumorigenicity") (:form . "tumorigenicity")\n  (:end . 198) (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 204)\n  (:start . 199) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s492.2) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004536@unknown@formal@none@1@S@The Bcd proto-oncogene was activated by a truncation in the 5' UTR.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bcd") (:form . "Bcd") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 22) (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "truncation") (:form . "truncation") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "utr") (:form . "UTR") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s492.3) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004537@unknown@formal@none@1@S@It predicts for two open reading frames (ORFs).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORFs") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s492.4) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004538@unknown@formal@none@1@S@ORF1 consists of 240 bp that would encode 80 amino acids, while the major ORF2 consists of 648 bp capable of coding for 216 amino acids.@(((:tag . "NNP") (:stem . "ORF1") (:form . "ORF1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "240") (:form . "240") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "orf2") (:form . "ORF2") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "CD") (:stem . "648") (:form . "648") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 105)\n  (:start . 98) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 115)\n  (:start . 109) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "CD") (:stem . "216") (:form . "216") (:end . 123) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 129)\n  (:start . 124) (:id . 67))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s492.5) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004540@unknown@formal@none@1@S@Transfection of an expression vector containing ORF2 but not full length cDNA was able to transform NIH3T3 cells and induce tumors in nude mice.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "orf2") (:form . "ORF2") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "VB") (:stem . "transform") (:form . "transform") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "nih3t3") (:form . "NIH3T3") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nude") (:form . "nude") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 143)\n  (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x492.7.1) (:span 57 60)))\n (:nscopes ((:id . :x492.7.1) (:span 57 77)))\n (:identifiers (:sid . :s492.7) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004541@unknown@formal@none@1@S@Bcd mRNA transcripts of < or = 2.6 kb were selectively expressed in PBL and testis of healthy individuals.@(((:tag . "NNP") (:stem . "Bcd") (:form . "Bcd") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "CD") (:stem . "2.6") (:form . "2.6") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 54)\n  (:start . 43) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "testis") (:form . "testis") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 93)\n  (:start . 86) (:id . 59))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s492.8) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004542@unknown@formal@none@1@S@Within the PBL, Bcd gene expression was restricted to CD19+ B-cells and absent from CD14+ monocytes and T-cells.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcd") (:form . "Bcd") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd19+") (:form . "CD19+") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "b-cell") (:form . "B-cells") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cd14+") (:form . "CD14+") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s492.9) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004543@unknown@formal@none@1@S@Bcd transcripts were detected in all normal PBL samples tested but not in several malignant human B-cell lines and not in 50 % of B-cells from B-CLL patients.@(((:tag . "NNP") (:stem . "Bcd") (:form . "Bcd") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 62) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x492.10.1) (:span 115 118))\n  ((:id . :x492.10.2) (:span 67 70)))\n (:nscopes ((:id . :x492.10.1) (:span 115 157))\n  ((:id . :x492.10.2) (:span 67 110)))\n (:identifiers (:sid . :s492.10) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004544@unknown@formal@none@1@S@However, stimulation of B-cells from B-CLL patients under conditions which induced differentiation into plasma cells was associated with induction of Bcd gene expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 98) (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 110)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 146)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bcd") (:form . "Bcd") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s492.11) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004545@unknown@formal@none@1@S@The Bcd gene may therefore play an important role in B-cell growth and development.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bcd") (:form . "Bcd") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x492.12.1) (:span 13 16)))\n (:hscopes ((:id . :x492.12.1) (:span 13 82)))\n (:identifiers (:sid . :s492.12) (:did . :|97152553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004546@unknown@formal@none@1@S@Pancreatic development and maturation of the islet B cell.@(((:tag . "JJ") (:stem . "pancreatic") (:form . "Pancreatic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "islet") (:form . "islet") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s493.1) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004547@unknown@formal@none@1@S@Studies of pluripotent islet cultures.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pluripotent") (:form . "pluripotent") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "islet") (:form . "islet") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s493.2) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004548@unknown@formal@none@1@S@Pancreas organogenesis is a highly regulated process, in which two anlage evaginate from the primitive gut.@(((:tag . "NN") (:stem . "pancreas") (:form . "Pancreas") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "organogenesis") (:form . "organogenesis")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "anlage") (:form . "anlage") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "evaginate") (:form . "evaginate") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "gut") (:form . "gut") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s493.3) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004550@unknown@formal@none@1@S@Early buds are characterized by a branching morphogenesis of the ductal epithelium from which endocrine and exocrine precursor cells bud to eventually form the two other compartments.@(((:tag . "JJ") (:stem . "early") (:form . "Early") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "bud") (:form . "buds") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "branching") (:form . "branching") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "morphogenesis") (:form . "morphogenesis")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ductal") (:form . "ductal") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "epithelium") (:form . "epithelium") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "exocrine") (:form . "exocrine") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "VBP") (:stem . "bud") (:form . "bud") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "RB") (:stem . "eventually") (:form . "eventually") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 182)\n  (:start . 170) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s493.5) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004551@unknown@formal@none@1@S@The three compartments are thought to be of common endodermal origin; in contrast to earlier hypotheses, which suggested that the endocrine compartment was of neuroectodermal origin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "endodermal") (:form . "endodermal") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NNS") (:stem . "hypothesis") (:form . "hypotheses") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 151)\n  (:start . 140) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "neuroectodermal") (:form . "neuroectodermal")\n  (:end . 174) (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 181)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x493.6.1) (:span 111 120))\n  ((:id . :x493.6.2) (:span 27 34)))\n (:hscopes ((:id . :x493.6.1) (:span 111 181))\n  ((:id . :x493.6.2) (:span 0 68)))\n (:identifiers (:sid . :s493.6) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004552@unknown@formal@none@1@S@It is thus generally believed that the pancreatic endocrine-lineage possesses the ability to mature along a differentiation pathway that shares many characteristics with those of neuronal differentiation.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "endocrine-lineage") (:form . "endocrine-lineage")\n  (:end . 67) (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "possess") (:form . "possesses") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "VB") (:stem . "mature") (:form . "mature") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 123) (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "share") (:form . "shares") (:end . 143)\n  (:start . 137) (:id . 61))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 164) (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 175)\n  (:start . 170) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "neuronal") (:form . "neuronal") (:end . 187)\n  (:start . 179) (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 203) (:start . 188) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x493.7.1) (:span 21 29)))\n (:hscopes ((:id . :x493.7.1) (:span 21 203)))\n (:identifiers (:sid . :s493.7) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004553@unknown@formal@none@1@S@During recent years, studies of insulin-gene regulation and , in particular, the tissue-specific transcriptional control of insulin-gene activity have provided information on pancreas development in general.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "insulin-gene") (:form . "insulin-gene") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 96) (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 112) (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "insulin-gene") (:form . "insulin-gene") (:end . 136)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 171)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 174) (:start . 172)\n  (:id . 65))\n ((:tag . "NN") (:stem . "pancreas") (:form . "pancreas") (:end . 183)\n  (:start . 175) (:id . 66))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 195)\n  (:start . 184) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 68))\n ((:tag . "NN") (:stem . "general") (:form . "general") (:end . 206)\n  (:start . 199) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s493.8) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004554@unknown@formal@none@1@S@The present review summarizes these findings, with a special focus on our own studies on pluripotent endocrine cultures of rat pancreas.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "summarize") (:form . "summarizes") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "special") (:form . "special") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "focus") (:form . "focus") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pluripotent") (:form . "pluripotent") (:end . 100)\n  (:start . 89) (:id . 58))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pancreas") (:form . "pancreas") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s493.9) (:did . :|97175006|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004555@unknown@formal@none@1@S@Induction of vascular cell adhesion molecule-1 by low-density lipoprotein.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "low-density") (:form . "low-density") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s494.1) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004556@unknown@formal@none@1@S@Low-density lipoprotein (LDL) is a well-established risk factor for atherosclerosis.@(((:tag . "JJ") (:stem . "low-density") (:form . "Low-density") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "well-established") (:form . "well-established")\n  (:end . 51) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 83) (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s494.2) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004557@unknown@formal@none@1@S@When endothelial cells are incubated with this lipoprotein in pathophysiologic amounts, the cells are activated.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pathophysiologic") (:form . "pathophysiologic")\n  (:end . 78) (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s494.3) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004558@unknown@formal@none@1@S@Among the documented cellular responses to LDL is increased recruitment of monocytes, which are believed to play a major role in promoting intimal plaque formation.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "JJ") (:stem . "intimal") (:form . "intimal") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "plaque") (:form . "plaque") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x494.4.1) (:span 96 104)))\n (:hscopes ((:id . :x494.4.1) (:span 86 163)))\n (:identifiers (:sid . :s494.4) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004560@unknown@formal@none@1@S@Human LDL induces the vascular cell adhesion molecule-1 (VCAM-1) transcriptionally with an increase in mRNA levels through activation of the VCAM promoter.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 82) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "VCAM") (:form . "VCAM") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s494.6) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004561@unknown@formal@none@1@S@This effect is blocked by anti-VCAM antibodies.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "anti-vcam") (:form . "anti-VCAM") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s494.7) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004562@unknown@formal@none@1@S@After a 2-day incubation in LDL, the binding of NF-kappa B, which is believed to be a key oxidative-stress sensor for VCAM regulation, remains at basal level.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "2-day") (:form . "2-day") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 77)\n  (:start . 69) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 83) (:start . 81)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 89) (:start . 86)\n  (:id . 61))\n ((:tag . "NN") (:stem . "oxidative-stress") (:form . "oxidative-stress")\n  (:end . 106) (:start . 90) (:id . 62))\n ((:tag . "NN") (:stem . "sensor") (:form . "sensor") (:end . 113)\n  (:start . 107) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "VCAM") (:form . "VCAM") (:end . 122) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 133)\n  (:start . 123) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 142)\n  (:start . 135) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 145) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 157)\n  (:start . 152) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x494.8.1) (:span 69 77)))\n (:hscopes ((:id . :x494.8.1) (:span 60 133)))\n (:identifiers (:sid . :s494.8) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004563@unknown@formal@none@1@S@In contrast, the binding activities of AP-1 and GATA, on the other hand, are increased by LDL.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 86)\n  (:start . 77) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 93) (:start . 90)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s494.9) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004564@unknown@formal@none@1@S@Thus, a component of LDL-enhanced endothelial recruitment of monocytes is attributed to VCAM-1 expression, which appears to be mediated through AP-1 and GATA.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 17)\n  (:start . 8) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ldl-enhanced") (:form . "LDL-enhanced") (:end . 33)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 157) (:start . 153)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x494.10.1) (:span 113 120)))\n (:hscopes ((:id . :x494.10.1) (:span 107 157)))\n (:identifiers (:sid . :s494.10) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004565@unknown@formal@none@1@S@These data identify LDL as a VCAM-inducer possibly distinct from cytokines and endotoxin.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "vcam-inducer") (:form . "VCAM-inducer") (:end . 41)\n  (:start . 29) (:id . 48))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x494.11.1) (:span 42 50)))\n (:hscopes ((:id . :x494.11.1) (:span 42 88)))\n (:identifiers (:sid . :s494.11) (:did . :|97175274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004566@unknown@formal@none@1@S@The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "CD62E") (:form . "CD62E") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD106") (:form . "CD106") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s495.1) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004567@unknown@formal@none@1@S@Tepoxalin, a dual enzyme inhibitor of cyclooxygenase and 5-lipoxygenase has been shown to inhibit T-cell activation.@(((:tag . "NNP") (:stem . "Tepoxalin") (:form . "Tepoxalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cyclooxygenase") (:form . "cyclooxygenase")\n  (:end . 52) (:start . 38) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 71) (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s495.2) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004568@unknown@formal@none@1@S@Its immunosuppressive property is distinct from cyclosporin because only tepoxalin, but not cyclosporin, suppresses NF-kappa B activation.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 82)\n  (:start . 73) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x495.3.1) (:span 88 91)))\n (:nscopes ((:id . :x495.3.1) (:span 88 103)))\n (:identifiers (:sid . :s495.3) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004570@unknown@formal@none@1@S@The mechanism of inhibition is related to the surface expression of several cell adhesion molecules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s495.5) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004571@unknown@formal@none@1@S@Flow cytometry analyses on cultured cells that were treated with tepoxalin or antisense oligonucleotides to the P65/p50 subunit of NF-kappa B, and then stimulated with PMA, revealed a reduced expression of CD11b/CD18 on monocytic HL60 cells, and endothelial adhesion molecule-1 (CD62E) and vascular adhesion molecule-1 (CD106) on human umbilical vein endothelial cells.@(((:tag . "NNP") (:stem . "Flow") (:form . "Flow") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . 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"vein") (:end . 350) (:start . 346)\n  (:id . 98))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 362)\n  (:start . 351) (:id . 99))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 368)\n  (:start . 363) (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 369) (:start . 368)\n  (:id . 101)))@@@1@60@((:identifiers (:sid . :s495.6) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004572@unknown@formal@none@1@S@Expression of other adhesion molecules such as lymphocyte function associated-antigen-1 (CD11a/CD18) and CD54 were unaffected.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "associated-antigen-1")\n  (:form . "associated-antigen-1") (:end . 87) (:start . 67) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd11a/cd18") (:form . "CD11a/CD18") (:end . 99)\n  (:start . 89) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD54") (:form . "CD54") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s495.7) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004573@unknown@formal@none@1@S@Tepoxalin also inhibited the secretion of a NF-kappa B regulated chemokine, IL-8, a known inducer of CD11b/CD18 expression.@(((:tag . "NNP") (:stem . "Tepoxalin") (:form . "Tepoxalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s495.8) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004574@unknown@formal@none@1@S@Thus the suppression of CD11b/CD18 expression by tepoxalin may involve IL-8.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x495.9.1) (:span 59 62)))\n (:hscopes ((:id . :x495.9.1) (:span 59 75)))\n (:identifiers (:sid . :s495.9) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004575@unknown@formal@none@1@S@Our results suggest that by inhibiting NF-kappa B activation, surface expression of several adhesion molecules can be modulated and that tepoxalin may be useful in treating selected adhesion mediated events such as leukocyte migration or atherosclerotic plaque formation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 160)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "treat") (:form . "treating") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 181)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 190)\n  (:start . 182) (:id . 70))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 199)\n  (:start . 191) (:id . 71))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 206)\n  (:start . 200) (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 211) (:start . 207)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 214) (:start . 212)\n  (:id . 74))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 224)\n  (:start . 215) (:id . 75))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 234)\n  (:start . 225) (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 237) (:start . 235)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 253) (:start . 238) (:id . 78))\n ((:tag . "NN") (:stem . "plaque") (:form . "plaque") (:end . 260)\n  (:start . 254) (:id . 79))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 270)\n  (:start . 261) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x495.10.1) (:span 147 150))\n  ((:id . :x495.10.2) (:span 12 19)))\n (:hscopes ((:id . :x495.10.1) (:span 147 270))\n  ((:id . :x495.10.2) (:span 12 270)))\n (:identifiers (:sid . :s495.10) (:did . :|97177471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004576@unknown@formal@none@1@S@Expression of erythroid-specific genes in megakaryoblastic disorders.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 32) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 38) (:start . 33)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "megakaryoblastic") (:form . "megakaryoblastic")\n  (:end . 58) (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 68)\n  (:start . 59) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s496.1) (:did . :|97182946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004577@unknown@formal@none@1@S@Currently available data indicate that erythroid and megakaryocytic differentiation pathways are closely related to each other, and there may exist progenitor cells common to those two lineages may exist.@(((:tag . "RB") (:stem . "currently") (:form . "Currently") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 67) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 83) (:start . 68) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 92)\n  (:start . 84) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 52))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 104)\n  (:start . 97) (:id . 53))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 112)\n  (:start . 105) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 55))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 120) (:start . 116)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 126)\n  (:start . 121) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 158)\n  (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 64))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 171)\n  (:start . 165) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 193)\n  (:start . 185) (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 203)\n  (:start . 198) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x496.2.1) (:span 194 197))\n  ((:id . :x496.2.2) (:span 138 141)) ((:id . :x496.2.3) (:span 25 38)))\n (:hscopes ((:id . :x496.2.1) (:span 194 203))\n  ((:id . :x496.2.2) (:span 138 203)) ((:id . :x496.2.3) (:span 25 203)))\n (:identifiers (:sid . :s496.2) (:did . :|97182946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004578@unknown@formal@none@1@S@Acute megakaryoblastic leukemia (AML-M7) and transient myeloproliferative disorder in Down 's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers.@(((:tag . "JJ") (:stem . "acute") (:form . "Acute") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "megakaryoblastic") (:form . "megakaryoblastic")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AML-M7") (:form . "AML-M7") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "myeloproliferative") (:form . "myeloproliferative")\n  (:end . 73) (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Down") (:form . "Down") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TMD") (:form . "TMD") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 195) (:start . 181) (:id . 70))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 203)\n  (:start . 196) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s496.3) (:did . :|97182946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004580@unknown@formal@none@1@S@These results suggest that blasts in M7 and TMD may correspond to progenitors of both erythroid and megakaryocytic lineages.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "M7") (:form . "M7") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TMD") (:form . "TMD") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "correspond") (:form . "correspond") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 114) (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x496.5.1) (:span 48 51)) ((:id . :x496.5.2) (:span 14 21)))\n (:hscopes ((:id . :x496.5.1) (:span 48 123))\n  ((:id . :x496.5.2) (:span 14 123)))\n (:identifiers (:sid . :s496.5) (:did . :|97182946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004581@unknown@formal@none@1@S@Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hallmark") (:form . "hallmark") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s497.1) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004582@unknown@formal@none@1@S@B lymphocytes from the peripheral blood of patients with chronic lymphocytic leukaemia (CLL) were analysed for the nuclear presence and DNA binding of a panel of transcription factors which are involved in the gene control of lymphoid cells.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CLL") (:form . "CLL") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 193) (:start . 190)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 202)\n  (:start . 194) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 214) (:start . 210)\n  (:id . 77))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 222)\n  (:start . 215) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 225) (:start . 223)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 234)\n  (:start . 226) (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s497.2) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004583@unknown@formal@none@1@S@The following transcription factors were studied: the Octamer factors Oct-1 and Oct-2, members of the AP-1 factor family, NF-AT factors, in particular NF-ATp, and members of the Rel/NF-kB family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Octamer") (:form . "Octamer") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 150)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "nf-atp") (:form . "NF-ATp") (:end . 157)\n  (:start . 151) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 170)\n  (:start . 163) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Rel/NF-kB") (:form . "Rel/NF-kB") (:end . 187)\n  (:start . 178) (:id . 74))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 194)\n  (:start . 188) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s497.3) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004584@unknown@formal@none@1@S@We show that the constitutive nuclear translocation of NF-ATp, a member of the growing family of NF-AT factors, is a hallmark of nonstimulated B cells from CLL patients that distinguishes B-CLL cells from ' normal ' B lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 102)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hallmark") (:form . "hallmark") (:end . 125)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nonstimulated") (:form . "nonstimulated")\n  (:end . 142) (:start . 129) (:id . 66))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CLL") (:form . "CLL") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "distinguish") (:form . "distinguishes")\n  (:end . 187) (:start . 174) (:id . 73))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 193)\n  (:start . 188) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 204) (:start . 200)\n  (:id . 76))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 206) (:start . 205)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 213)\n  (:start . 207) (:id . 78))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 215) (:start . 214)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 217) (:start . 216)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 229)\n  (:start . 218) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s497.4) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004585@unknown@formal@none@1@S@Constitutive nuclear appearance was also observed for NF-kB2/p52.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nf-kb2/p52") (:form . "NF-kB2/p52") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s497.5) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004586@unknown@formal@none@1@S@Constitutive binding of further factor proteins to DNA, such as JunD, c-Fos and FosB, was detected in several patients whereas the localisation and DNA binding of other factors such as c-Jun, RelA/p65 and c-Rel was unaltered.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "JunD") (:form . "JunD") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FosB") (:form . "FosB") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 98)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "localisation") (:form . "localisation") (:end . 143)\n  (:start . 131) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 176)\n  (:start . 169) (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 181) (:start . 177)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 190)\n  (:start . 185) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . "NN") (:stem . "rela/p65") (:form . "RelA/p65") (:end . 200)\n  (:start . 192) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 78))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 210)\n  (:start . 205) (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 214) (:start . 211)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 224)\n  (:start . 215) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s497.6) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004587@unknown@formal@none@1@S@It is remarkable that in B-CLL cells the nuclear appearance and DNA binding of specific transcription factors is dramatically affected whereas other members of the same factor family remained unaltered in these leukemic cells.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "remarkable") (:form . "remarkable") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B-CLL") (:form . "B-CLL") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 125)\n  (:start . 113) (:id . 60))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 148)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 168) (:start . 164)\n  (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 175)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 191)\n  (:start . 183) (:id . 70))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 201)\n  (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 219)\n  (:start . 211) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s497.7) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004588@unknown@formal@none@1@S@It remains to be shown which molecular events lead to the specific ' pre-activation ', i.e. constitutive nuclear translocation and DNA binding, of these members of NF-AT, NF-kB and AP-1 factor families.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "specific") (:form . "specific") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pre-activation") (:form . "pre-activation")\n  (:end . 83) (:start . 69) (:id . 55))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 104)\n  (:start . 92) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 126) (:start . 113) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 169)\n  (:start . 164) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 192)\n  (:start . 186) (:id . 75))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 201)\n  (:start . 193) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s497.8) (:did . :|97182951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004590@unknown@formal@none@1@S@In order to inquire into the functional state of adrenal cortex in patients with pulmonary heart disease, the number of glucocorticoid receptors(GCR) of peripheral blood leukocytes in patients with chronic pulmonary heart disease was determined with radioligand-binding assay and the corresponding plasma cortisol levels were assessed with radioimmune assays.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "inquire") (:form . "inquire") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "functional") (:form . 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"assess") (:form . "assessed") (:end . 334)\n  (:start . 326) (:id . 88))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 339) (:start . 335)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "radioimmune") (:form . "radioimmune") (:end . 351)\n  (:start . 340) (:id . 90))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 358)\n  (:start . 352) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 359) (:start . 358)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s498.2) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004591@unknown@formal@none@1@S@The results showed that the number of GCR in the patients was significantly reduced (P < 0.01) and it was increased when their health state was improved.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 75) (:start . 62) (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 115)\n  (:start . 106) (:id . 64))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "health") (:form . "health") (:end . 133)\n  (:start . 127) (:id . 67))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 139)\n  (:start . 134) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 152)\n  (:start . 144) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s498.3) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004592@unknown@formal@none@1@S@However, it was still lower than that in healthy subjects (P < 0.01).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 67) (:start . 63)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s498.4) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004593@unknown@formal@none@1@S@The number of GCR in the patients was greatly increased when these patients were treated with oxygen (P < 0.01).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s498.5) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004594@unknown@formal@none@1@S@No difference in plasma cortisol was found between the patients and the healthy subjects (P > 0.05).@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "cortisol") (:form . "cortisol") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJR") (:stem . ">") (:form . ">") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s498.6) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004595@unknown@formal@none@1@S@These results indicate that the function of adrenal cortex may be improved by the compensation mechanism of the patients, but the lower GCR number was the result of lacking of oxygen in the patients.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 135) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 161)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lacking") (:form . "lacking") (:end . 172)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 182)\n  (:start . 176) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 198)\n  (:start . 190) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x498.7.2) (:span 59 62)) ((:id . :x498.7.3) (:span 14 27)))\n (:ncues ((:id . :x498.7.1) (:span 165 172)))\n (:hscopes ((:id . :x498.7.2) (:span 28 120))\n  ((:id . :x498.7.3) (:span 14 198)))\n (:nscopes ((:id . :x498.7.1) (:span 165 198)))\n (:identifiers (:sid . :s498.7) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004596@unknown@formal@none@1@S@The number of GCR may be improved by inhalation of oxygen.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GCR") (:form . "GCR") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inhalation") (:form . "inhalation") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x498.8.1) (:span 18 21)))\n (:hscopes ((:id . :x498.8.1) (:span 0 57)))\n (:identifiers (:sid . :s498.8) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004597@unknown@formal@none@1@S@Therefore oxygen therapy is helpful in raising the activity of glucocorticoid receptors and controlling the development of the disease.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "helpful") (:form . "helpful") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "raise") (:form . "raising") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 119)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s498.9) (:did . :|98048869|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004598@unknown@formal@none@1@S@Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 99) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 115)\n  (:start . 106) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 56))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 129)\n  (:start . 122) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 141)\n  (:start . 135) (:id . 59))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 152)\n  (:start . 142) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s499.1) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004600@unknown@formal@none@1@S@The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s499.3) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004601@unknown@formal@none@1@S@Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 47)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 72)\n  (:start . 64) (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 77) (:start . 73)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 92)\n  (:start . 83) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 113)\n  (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 126) (:start . 122)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 156)\n  (:start . 144) (:id . 69))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 166)\n  (:start . 157) (:id . 70))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 181)\n  (:start . 172) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 196)\n  (:start . 186) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 201) (:start . 197)\n  (:id . 75))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 220) (:start . 202) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x499.4.1) (:span 83 92)))\n (:hscopes ((:id . :x499.4.1) (:span 0 220)))\n (:identifiers (:sid . :s499.4) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004602@unknown@formal@none@1@S@Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently.@(((:tag . "JJ") (:stem . "nonsteroidal") (:form . "Nonsteroidal") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 30) (:start . 13) (:id . 43))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 36) (:start . 31)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 41) (:start . 37)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "salicylate") (:form . "salicylates") (:end . 56)\n  (:start . 45) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "VB") (:stem . "treat") (:form . "treat") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 105)\n  (:start . 93) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 141)\n  (:start . 135) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s499.5) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004603@unknown@formal@none@1@S@Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor " I kappa B ", blocking the translocation of NF-kappa B into the nuclear compartment.@(((:tag . "NNS") (:stem . "salicylate") (:form . "Salicylates") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 65) (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 88) (:start . 85)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 99)\n  (:start . 89) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 111)\n  (:start . 103) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 138)\n  (:start . 128) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 154)\n  (:start . 143) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 166)\n  (:start . 158) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 178)\n  (:start . 169) (:id . 64))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 180) (:start . 179)\n  (:id . 65))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 182) (:start . 181)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 188)\n  (:start . 183) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 190) (:start . 189)\n  (:id . 68))\n ((:tag . "``") (:stem . "``") (:form . "\\"") (:end . 192) (:start . 191)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 202)\n  (:start . 194) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 220) (:start . 207) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 232)\n  (:start . 224) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 234) (:start . 233)\n  (:id . 76))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 239) (:start . 235)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 243) (:start . 240)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 251)\n  (:start . 244) (:id . 79))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 263)\n  (:start . 252) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s499.6) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004604@unknown@formal@none@1@S@However, the nature of the subunit involved in this mechanism has not been defined.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x499.7.1) (:span 66 69)))\n (:nscopes ((:id . :x499.7.1) (:span 9 82)))\n (:identifiers (:sid . :s499.7) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004605@unknown@formal@none@1@S@To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "salicylate") (:form . "salicylates") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Porphyromonas") (:form . "Porphyromonas")\n  (:end . 165) (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "gingivalis") (:form . "gingivalis") (:end . 176)\n  (:start . 166) (:id . 69))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 206) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 212)\n  (:start . 207) (:id . 71))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 222)\n  (:start . 213) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 228)\n  (:start . 223) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 232) (:start . 229)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 241)\n  (:start . 233) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s499.8) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004606@unknown@formal@none@1@S@High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 75)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 152) (:start . 137) (:id . 65))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 197) (:start . 171)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 206)\n  (:start . 198) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 208) (:start . 207)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 219)\n  (:start . 209) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x499.9.1) (:span 157 159)))\n (:nscopes ((:id . :x499.9.1) (:span 157 219)))\n (:identifiers (:sid . :s499.9) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004607@unknown@formal@none@1@S@The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "highlight") (:form . "highlight") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 179)\n  (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 189)\n  (:start . 180) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s499.10) (:did . :|98128482|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004608@unknown@formal@none@1@S@Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients.@(((:tag . "NN") (:stem . "lack") (:form . "Lack") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "t-cell-mediated") (:form . "T-cell-mediated")\n  (:end . 23) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pml/rar-alpha") (:form . "pml/RAR-alpha")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 130) (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 148)\n  (:start . 140) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x500.1.1) (:span 0 4)))\n (:nscopes ((:id . :x500.1.1) (:span 0 148)))\n (:identifiers (:sid . :s500.1) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004610@unknown@formal@none@1@S@We present here the results on the recognition of several pml/RAR-alpha peptides by APL patients expressing HLA DR11.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "pml/rar-alpha") (:form . "pml/RAR-alpha")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DR11") (:form . "DR11") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s500.3) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004611@unknown@formal@none@1@S@The in vitro immunization of peripheral blood lymphocytes from four patients in remission (S.R., F.R., M.M., P. G.) with BCR1/25, a 25-mer pml/RAR-alpha, did not elicit either a polyclonal or a clonal immune response specific to the peptide.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunization") (:form . "immunization") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "remission") (:form . "remission") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "S.R.") (:form . "S.R.") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "F.R.") (:form . "F.R.") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "M.M.") (:form . "M.M.") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "P.") (:form . "P.") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BCR1/25") (:form . "BCR1/25") (:end . 128)\n  (:start . 121) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 68))\n ((:tag . "NN") (:stem . "25-mer") (:form . "25-mer") (:end . 138)\n  (:start . 132) (:id . 69))\n ((:tag . "NN") (:stem . "pml/rar-alpha") (:form . "pml/RAR-alpha")\n  (:end . 152) (:start . 139) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 157) (:start . 154)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 161) (:start . 158)\n  (:id . 73))\n ((:tag . "VB") (:stem . "elicit") (:form . "elicit") (:end . 168)\n  (:start . 162) (:id . 74))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 175)\n  (:start . 169) (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 188)\n  (:start . 178) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 191) (:start . 189)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 200)\n  (:start . 194) (:id . 80))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 207)\n  (:start . 201) (:id . 81))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 216)\n  (:start . 208) (:id . 82))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 225)\n  (:start . 217) (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 228) (:start . 226)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 85))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 240)\n  (:start . 233) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x500.4.1) (:span 158 161)))\n (:nscopes ((:id . :x500.4.1) (:span 158 240)))\n (:identifiers (:sid . :s500.4) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004612@unknown@formal@none@1@S@We then generated new donor anti-pml/RAR-alpha CD4(+) T-cell clones.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "donor") (:form . "donor") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "anti-pml/rar-alpha") (:form . "anti-pml/RAR-alpha")\n  (:end . 46) (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s500.5) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004613@unknown@formal@none@1@S@These clones were tested for their recognition of BCR1/25.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 24) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 34)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bcr1/25") (:form . "BCR1/25") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s500.6) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004614@unknown@formal@none@1@S@One clone (C3/5, CD3(+), CD4(+), CD8(-)) was selected for further analysis.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C3/5") (:form . "C3/5") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD3(+)") (:form . "CD3(+)") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 31)\n  (:start . 25) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD8(-))") (:form . "CD8(-))") (:end . 40)\n  (:start . 33) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 53)\n  (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 65)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s500.7) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004615@unknown@formal@none@1@S@Clone C3/5 showed specific proliferation, cytotoxicity, and cytokine (tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor) production when challenged with autologous lymphoblastic cell lines pulsed with peptide BCR1/25.@(((:tag . "NNP") (:stem . "Clone") (:form . "Clone") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C3/5") (:form . "C3/5") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 17) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 121) (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 140) (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 164) (:start . 160)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "challenge") (:form . "challenged") (:end . 175)\n  (:start . 165) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "autologous") (:form . "autologous") (:end . 191)\n  (:start . 181) (:id . 66))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 205) (:start . 192) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 210) (:start . 206)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 216)\n  (:start . 211) (:id . 69))\n ((:tag . "VBN") (:stem . "pulse") (:form . "pulsed") (:end . 223)\n  (:start . 217) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 228) (:start . 224)\n  (:id . 71))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 236)\n  (:start . 229) (:id . 72))\n ((:tag . "NN") (:stem . "bcr1/25") (:form . "BCR1/25") (:end . 244)\n  (:start . 237) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s500.8) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004616@unknown@formal@none@1@S@C3/5 cells developed specific proliferation and cytotoxicity when challenged with peptide-pulsed lymphoblastic cell lines and peripheral blood lymphocytes from the four DR11(+) APL patients.@(((:tag . "NNP") (:stem . "C3/5") (:form . "C3/5") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 60)\n  (:start . 48) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "challenge") (:form . "challenged") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peptide-pulsed") (:form . "peptide-pulsed")\n  (:end . 96) (:start . 82) (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 110) (:start . 97) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 121)\n  (:start . 116) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 136)\n  (:start . 126) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 142)\n  (:start . 137) (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 154)\n  (:start . 143) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 159) (:start . 155)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 61))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 168) (:start . 164)\n  (:id . 62))\n ((:tag . "CD") (:stem . "DR11(+)") (:form . "DR11(+)") (:end . 176)\n  (:start . 169) (:id . 63))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 180) (:start . 177)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 189)\n  (:start . 181) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s500.9) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004617@unknown@formal@none@1@S@APL blasts, available only from patients F.R. and P.G., were not lysed by C3/5 and were unable to present peptide BCR1/25.@(((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "F.R.") (:form . "F.R.") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "P.G.") (:form . "P.G.") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "lyse") (:form . "lysed") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C3/5") (:form . "C3/5") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 87) (:start . 83)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 94)\n  (:start . 88) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "VB") (:stem . "present") (:form . "present") (:end . 105)\n  (:start . 98) (:id . 62))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 113)\n  (:start . 106) (:id . 63))\n ((:tag . "NN") (:stem . "bcr1/25") (:form . "BCR1/25") (:end . 121)\n  (:start . 114) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x500.10.1) (:span 88 94))\n  ((:id . :x500.10.2) (:span 61 64)))\n (:nscopes ((:id . :x500.10.1) (:span 88 121))\n  ((:id . :x500.10.2) (:span 0 78)))\n (:identifiers (:sid . :s500.10) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004618@unknown@formal@none@1@S@Incubation of APL cells with IFN-gamma failed to induce HLA class II molecules and recognition by the C3/5 clone.@(((:tag . "NNP") (:stem . "Incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 45) (:start . 39)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c3/5") (:form . "C3/5") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x500.11.1) (:span 39 45)))\n (:nscopes ((:id . :x500.11.1) (:span 39 78)))\n (:identifiers (:sid . :s500.11) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004620@unknown@formal@none@1@S@No peptide-specific T-cell line or clone could be generated from both donors and patients.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peptide-specific") (:form . "peptide-specific")\n  (:end . 19) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x500.13.1) (:span 0 2)))\n (:nscopes ((:id . :x500.13.1) (:span 0 89)))\n (:identifiers (:sid . :s500.13) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004621@unknown@formal@none@1@S@These findings are discussed in relation to possible therapeutic approaches to the immunotherapy of APL.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunotherapy") (:form . "immunotherapy")\n  (:end . 96) (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x500.14.1) (:span 44 52)))\n (:hscopes ((:id . :x500.14.1) (:span 44 103)))\n (:identifiers (:sid . :s500.14) (:did . :|99035056|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004622@unknown@formal@none@1@S@Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.@(((:tag . "JJ") (:stem . "reactive") (:form . "Reactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intermediate-dependent")\n  (:form . "intermediate-dependent") (:end . 38) (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 80) (:start . 63) (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 89)\n  (:start . 81) (:id . 49))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 104) (:start . 90) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NADPH") (:form . "NADPH") (:end . 113)\n  (:start . 108) (:id . 52))\n ((:tag . "NN") (:stem . "oxidase") (:form . "oxidase") (:end . 121)\n  (:start . 114) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s501.1) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004623@unknown@formal@none@1@S@We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 69) (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROIs") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 119) (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s501.2) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004624@unknown@formal@none@1@S@However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "source") (:form . "sources") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "roi") (:form . "ROIs") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 76)\n  (:start . 66) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 109) (:start . 95) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NADPH") (:form . "NADPH") (:end . 127)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "oxidase") (:form . "oxidase") (:end . 135)\n  (:start . 128) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x501.3.1) (:span 81 86)))\n (:hscopes ((:id . :x501.3.1) (:span 81 135)))\n (:identifiers (:sid . :s501.3) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004625@unknown@formal@none@1@S@5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells.@(((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FLAP") (:form . "FLAP") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x501.4.1) (:span 80 83)))\n (:nscopes ((:id . :x501.4.1) (:span 80 116)))\n (:identifiers (:sid . :s501.4) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004626@unknown@formal@none@1@S@Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 52) (:start . 35) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 155)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "FLAP") (:form . "FLAP") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 174)\n  (:start . 164) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "confirm") (:form . "confirming") (:end . 186)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 191) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 212)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROIs") (:end . 220) (:start . 216)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 228) (:start . 225)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 237)\n  (:start . 229) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 241) (:start . 238)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 251)\n  (:start . 242) (:id . 82))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 262)\n  (:start . 252) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 265) (:start . 263)\n  (:id . 84))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 271)\n  (:start . 266) (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 277)\n  (:start . 272) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s501.5) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004627@unknown@formal@none@1@S@IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors.@(((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNPS") (:stem . "ROI") (:form . "ROIs") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x501.6.1) (:span 95 98)) ((:id . :x501.6.2) (:span 45 48)))\n (:nscopes ((:id . :x501.6.1) (:span 71 129))\n  ((:id . :x501.6.2) (:span 45 66)))\n (:identifiers (:sid . :s501.6) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004628@unknown@formal@none@1@S@However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "reintroduction") (:form . "reintroduction")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "5-lox") (:form . "5-LOX") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "5-lox-dependent") (:form . "5-LOX-dependent")\n  (:end . 110) (:start . 95) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s501.7) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004630@unknown@formal@none@1@S@This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rac1") (:form . "Rac1") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cdc42") (:form . "Cdc42") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gtpas") (:form . "GTPases") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x501.9.1) (:span 72 75)))\n (:nscopes ((:id . :x501.9.1) (:span 62 141)))\n (:identifiers (:sid . :s501.9) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004631@unknown@formal@none@1@S@In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . 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"cells") (:end . 295)\n  (:start . 290) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s501.10) (:did . :|10022882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004632@unknown@formal@none@1@S@Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment.@(((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "Activation-dependent") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 36) (:start . 21) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 47)\n  (:start . 37) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 64) (:start . 61)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 82)\n  (:start . 74) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 92)\n  (:start . 83) (:id . 51))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 100)\n  (:start . 93) (:id . 52))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 112)\n  (:start . 101) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s502.1) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004633@unknown@formal@none@1@S@Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis.@(((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 9) (:start . 5)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 18) (:start . 15)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 25)\n  (:start . 19) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD95L") (:form . "CD95L") (:end . 32) (:start . 27)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 52)\n  (:start . 41) (:id . 54))\n ((:tag . "JJ") (:stem . "receptor-ligand") (:form . "receptor-ligand")\n  (:end . 68) (:start . 53) (:id . 55))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 93)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s502.2) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004634@unknown@formal@none@1@S@Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis.@(((:tag . "NNP") (:stem . "Lymphocyte") (:form . "Lymphocyte") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acquisition") (:form . "acquisition") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "fasl-mediated") (:form . "FasL-mediated")\n  (:end . 119) (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 129)\n  (:start . 120) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s502.3) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004635@unknown@formal@none@1@S@Although Fas upregulation is central to the preservation of immunologic tolerance, little is known about the molecular machinery underlying this process.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "preservation") (:form . "preservation") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s502.4) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004636@unknown@formal@none@1@S@To investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 56) (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 73)\n  (:start . 61) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 109)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fas") (:form . "fas") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 190)\n  (:start . 183) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 195) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 203)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 213)\n  (:start . 204) (:id . 73))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 221)\n  (:start . 214) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 235)\n  (:start . 226) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "P/I") (:form . "P/I") (:end . 240) (:start . 237)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 241) (:start . 240)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 242) (:start . 241)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "pharmacological") (:form . "pharmacological")\n  (:end . 258) (:start . 243) (:id . 81))\n ((:tag . "NNS") (:stem . "mimic") (:form . "mimics") (:end . 265)\n  (:start . 259) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 268) (:start . 266)\n  (:id . 83))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 275)\n  (:start . 269) (:id . 84))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 284)\n  (:start . 276) (:id . 85))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 295)\n  (:start . 285) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s502.5) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004637@unknown@formal@none@1@S@Although resting Jurkat cells express Fas, Fas mRNA was induced approximately 10-fold in 2 h upon P/I stimulation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 16) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "P/I") (:form . "P/I") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 113)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s502.6) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004638@unknown@formal@none@1@S@Using sequential deletion mutants of the human fas promoter in transient transfection assays, we identified a 47-bp sequence (positions -306 to -260 relative to the ATG) required for activation-driven fas upregulation.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "sequential") (:form . "sequential") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fas") (:form . "fas") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "47-bp") (:form . "47-bp") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "CD") (:stem . "-306") (:form . "-306") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-260") (:form . "-260") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "ATG") (:form . "ATG") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 178)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 182) (:start . 179)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "activation-driven") (:form . "activation-driven")\n  (:end . 200) (:start . 183) (:id . 73))\n ((:tag . "NN") (:stem . "fas") (:form . "fas") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 217)\n  (:start . 205) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s502.7) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004640@unknown@formal@none@1@S@Electrophoretic mobility shift assay (EMSA) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of p50-p65 NF-kappaB heterodimers after P/I activation.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "VBD") (:stem . "document") (:form . "documented") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 106)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unactivated") (:form . "unactivated") (:end . 136)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 167)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 175)\n  (:start . 168) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 186)\n  (:start . 179) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 209)\n  (:start . 197) (:id . 70))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 215)\n  (:start . 210) (:id . 71))\n ((:tag . "NNP") (:stem . "P/I") (:form . "P/I") (:end . 219) (:start . 216)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 230)\n  (:start . 220) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s502.9) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004641@unknown@formal@none@1@S@Sp1 and NF-kappaB transcription factor binding was shown to be mutually exclusive by EMSA displacement studies with purified recombinant Sp1 and recombinant p50.@(((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "mutually") (:form . "mutually") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "displacement") (:form . "displacement") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 136)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 156)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s502.10) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004642@unknown@formal@none@1@S@The functional contribution of the kappaB-Sp1 composite site in P/I-inducible fas promoter activation was verified by using kappaB-Sp1 concatamers (-295 to -286) in a thymidine kinase promoter-driven reporter construct and native promoter constructs in Jurkat cells overexpressing IkappaB-alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappab-sp1") (:form . "kappaB-Sp1") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "p/i-inducible") (:form . "P/I-inducible")\n  (:end . 77) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "fas") (:form . "fas") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "verify") (:form . "verified") (:end . 114)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 123) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappab-sp1") (:form . "kappaB-Sp1") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "concatamer") (:form . "concatamers") (:end . 146)\n  (:start . 135) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-295") (:form . "-295") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-286") (:form . "-286") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 176)\n  (:start . 167) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 183)\n  (:start . 177) (:id . 69))\n ((:tag . "JJ") (:stem . "promoter-driven") (:form . "promoter-driven")\n  (:end . 199) (:start . 184) (:id . 70))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 208)\n  (:start . 200) (:id . 71))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 218)\n  (:start . 209) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 229)\n  (:start . 223) (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 238)\n  (:start . 230) (:id . 75))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 249)\n  (:start . 239) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 259)\n  (:start . 253) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 265)\n  (:start . 260) (:id . 79))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 280) (:start . 266) (:id . 80))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 294) (:start . 281) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s502.11) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004643@unknown@formal@none@1@S@Site-directed mutagenesis of the critical guanine nucleotides in the kappaB-Sp1 element documented the essential role of this site in activation-dependent fas promoter induction.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappab-sp1") (:form . "kappaB-Sp1") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "VBD") (:stem . "document") (:form . "documented") (:end . 98)\n  (:start . 88) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 117) (:start . 113)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 154) (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "fas") (:form . "fas") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 167)\n  (:start . 159) (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 177)\n  (:start . 168) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s502.12) (:did . :|10022897|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004644@unknown@formal@none@1@S@RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.@(((:tag . "NN") (:stem . "rflat-1") (:form . "RFLAT-1") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s503.1) (:did . :|10023774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004645@unknown@formal@none@1@S@RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells.@(((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "regulate") (:form . "Regulated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "Normal") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "Expressed") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "secrete") (:form . "Secreted") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 93) (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 142)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 158)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "infiltrate") (:form . "infiltrate") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 196) (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 202)\n  (:start . 197) (:id . 72))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 208)\n  (:start . 203) (:id . 73))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 213) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 220)\n  (:start . 214) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s503.2) (:did . :|10023774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004646@unknown@formal@none@1@S@RANTES is expressed late (3-5 days) after activation in T lymphocytes.@(((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "3-5") (:form . "3-5") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 69)\n  (:start . 58) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s503.3) (:did . :|10023774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004647@unknown@formal@none@1@S@Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "\\"late") (:form . "\\"late") (:end . 55)\n  (:start . 50) (:id . 50))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "name") (:form . "named") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "\\"RANTES") (:form . "\\"RANTES") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "Factor") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "late") (:form . "Late") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Lymphocytes-1") (:form . "Lymphocytes-1")\n  (:end . 163) (:start . 150) (:id . 66))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 164) (:start . 163)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "RFLAT-1") (:form . "RFLAT-1") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s503.4) (:did . :|10023774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004648@unknown@formal@none@1@S@RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression.@(((:tag . "NNP") (:stem . "RFLAT-1") (:form . "RFLAT-1") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 34) (:start . 20) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "coincident") (:form . "coincident") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 145)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s503.5) (:did . :|10023774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004650@unknown@formal@none@1@S@Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "alpha-") (:form . "alpha-") (:end . 60)\n  (:start . 54) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "gamma-") (:form . "gamma-") (:end . 82)\n  (:start . 76) (:id . 51))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 111)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 120)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 136) (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 145)\n  (:start . 140) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s504.1) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004651@unknown@formal@none@1@S@Interleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "help") (:form . "helps") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "polarize") (:form . "polarized") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "T-helper") (:form . "T-helper") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "T-helper") (:form . "T-helper") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s504.2) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004652@unknown@formal@none@1@S@Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation.@(((:tag . "NN") (:stem . "part") (:form . "Part") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 118)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 145)\n  (:start . 139) (:id . 69))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 155)\n  (:start . 146) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 168)\n  (:start . 159) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 175) (:start . 173)\n  (:id . 74))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 185)\n  (:start . 176) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 76))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 192) (:start . 189)\n  (:id . 77))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 206) (:start . 193) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s504.3) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004653@unknown@formal@none@1@S@Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "th1-type") (:form . "Th1-type") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "delayed-type") (:form . "delayed-type") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 118) (:start . 102) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 142)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 174)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 185)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IFNgamma-") (:form . "IFNgamma-") (:end . 198)\n  (:start . 189) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "ifnalpha-induced") (:form . "IFNalpha-induced")\n  (:end . 219) (:start . 203) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 224) (:start . 220)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 235)\n  (:start . 225) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 238) (:start . 236)\n  (:id . 74))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 244)\n  (:start . 239) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 250)\n  (:start . 245) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x504.4.1) (:span 143 145)))\n (:hscopes ((:id . :x504.4.1) (:span 143 250)))\n (:identifiers (:sid . :s504.4) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004654@unknown@formal@none@1@S@Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha.@(((:tag . "RB") (:stem . "highly") (:form . "Highly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IFNalpha") (:form . "IFNalpha") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s504.5) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004655@unknown@formal@none@1@S@IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "preincubation") (:form . "preincubation")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "JJ") (:stem . "ifn-induced") (:form . "IFN-induced") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IP-10") (:form . "IP-10") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ISG54") (:form . "ISG54") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 136) (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s504.6) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004656@unknown@formal@none@1@S@The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "ifn-induced") (:form . "IFN-induced") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 179)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 195)\n  (:start . 189) (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ifnalpha-") (:form . "IFNalpha-") (:end . 208)\n  (:start . 199) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "ifngamma-inducible") (:form . "IFNgamma-inducible")\n  (:end . 231) (:start . 213) (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 237)\n  (:start . 232) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s504.7) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004657@unknown@formal@none@1@S@This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "accomplish") (:form . "accomplished") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ifn-induced") (:form . "IFN-induced") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 76) (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFNalpha-") (:form . "IFNalpha-") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ifngamma-induced") (:form . "IFNgamma-induced")\n  (:end . 137) (:start . 121) (:id . 60))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 159)\n  (:start . 150) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s504.8) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004658@unknown@formal@none@1@S@Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "stat-dependent") (:form . "STAT-dependent")\n  (:end . 52) (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IFNalpha") (:form . "IFNalpha") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 149)\n  (:start . 138) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 178) (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 187)\n  (:start . 182) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s504.9) (:did . :|10029571|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004660@unknown@formal@none@1@S@The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "megakaryocyte/platelet-specific")\n  (:form . "Megakaryocyte/Platelet-specific") (:end . 35) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 44)\n  (:start . 36) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha2beta1") (:form . "alpha2beta1") (:end . 63)\n  (:start . 52) (:id . 47))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 72)\n  (:start . 64) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 78) (:start . 77)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 125) (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 133)\n  (:start . 126) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 140)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 150)\n  (:start . 141) (:id . 60))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 158)\n  (:start . 151) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s505.1) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004661@unknown@formal@none@1@S@The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha2beta1") (:form . "alpha2beta1") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "collagen") (:form . "collagen") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s505.2) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004662@unknown@formal@none@1@S@Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha2") (:form . "alpha2") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 89) (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 105) (:start . 90) (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 114)\n  (:start . 106) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 55))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 130)\n  (:start . 122) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 138)\n  (:start . 131) (:id . 58))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 141) (:start . 139)\n  (:id . 59))\n ((:tag . "CD") (:stem . "-30") (:form . "-30") (:end . 145) (:start . 142)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-92") (:form . "-92") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-92") (:form . "-92") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "CD") (:stem . "-351") (:form . "-351") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 209) (:start . 195) (:id . 73))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 219)\n  (:start . 210) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 233)\n  (:start . 227) (:id . 77))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 235) (:start . 234)\n  (:id . 78))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 236) (:start . 235)\n  (:id . 79))\n ((:tag . "NN") (:stem . "flank") (:form . "flank") (:end . 242)\n  (:start . 237) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s505.3) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004663@unknown@formal@none@1@S@We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "229-bp") (:form . "229-bp") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "flank") (:form . "flank") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha2") (:form . "alpha2") (:end . 75)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 98)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 113)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 160) (:start . 146) (:id . 68))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s505.4) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004664@unknown@formal@none@1@S@Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dyad") (:form . "dyad") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "symmetry") (:form . "symmetry") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-fos/c-jun") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s505.5) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004665@unknown@formal@none@1@S@The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 77) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "alpha2") (:form . "alpha2") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x505.6.1) (:span 35 44)))\n (:hscopes ((:id . :x505.6.1) (:span 35 163)))\n (:identifiers (:sid . :s505.6) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004666@unknown@formal@none@1@S@Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PD98059") (:form . "PD98059") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha2") (:form . "alpha2") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 187) (:start . 173) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s505.7) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004667@unknown@formal@none@1@S@We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin enhancer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 52) (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha2") (:form . "alpha2") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 187)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "alpha2") (:form . "alpha2") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 219)\n  (:start . 211) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s505.8) (:did . :|10029589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004668@unknown@formal@none@1@S@Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 43) (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 76) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 110) (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s506.1) (:did . :|10037138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004670@unknown@formal@none@1@S@Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s506.3) (:did . :|10037138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004671@unknown@formal@none@1@S@Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 61) (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 92) (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 109)\n  (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 118)\n  (:start . 110) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s506.4) (:did . :|10037138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004672@unknown@formal@none@1@S@We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 23) (:start . 19)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 28) (:start . 24)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 64) (:start . 50) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 71)\n  (:start . 65) (:id . 56))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 80)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 96) (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 133) (:start . 129)\n  (:id . 68))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 149) (:start . 134) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "retard") (:form . "retarded") (:end . 161)\n  (:start . 153) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 181)\n  (:start . 171) (:id . 74))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 191) (:start . 187)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 77))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 200)\n  (:start . 195) (:id . 78))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 201) (:start . 200)\n  (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 203) (:start . 202)\n  (:id . 80))\n ((:tag . "LS") (:stem . "iii") (:form . "iii") (:end . 206) (:start . 203)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 212) (:start . 208)\n  (:id . 83))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 220)\n  (:start . 213) (:id . 84))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 223) (:start . 221)\n  (:id . 85))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 238) (:start . 224) (:id . 86))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 253) (:start . 239) (:id . 87))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 257) (:start . 254)\n  (:id . 88))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 261) (:start . 258)\n  (:id . 89))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 277) (:start . 262) (:id . 90))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 286)\n  (:start . 278) (:id . 91))\n ((:tag . "VBP") (:stem . "depend") (:form . "depend") (:end . 293)\n  (:start . 287) (:id . 92))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 296) (:start . 294)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 300) (:start . 297)\n  (:id . 94))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 316) (:start . 301) (:id . 95))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 324)\n  (:start . 317) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 325) (:start . 324)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s506.5) (:did . :|10037138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004673@unknown@formal@none@1@S@We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "conclude") (:form . "concluded") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CTCF") (:form . "CTCF") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 79) (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 104) (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 111)\n  (:start . 105) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s506.6) (:did . :|10037138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004674@unknown@formal@none@1@S@T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer.@(((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-lineage-specific")\n  (:form . "non-lineage-specific") (:end . 81) (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s507.1) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004675@unknown@formal@none@1@S@The GATA-3 transcription factor is required for development of the T-cell lineage and Th2 cytokine gene expression in CD4 T-cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD4") (:form . "CD4") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s507.2) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004676@unknown@formal@none@1@S@We have mapped the DNase-I-hypersensitive (HS) regions of the human GATA-3 gene in T-cells and non-T-cells and studied their transcriptional activities.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dnase-i-hypersensitive")\n  (:form . "DNase-I-hypersensitive") (:end . 41) (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "non-t-cell") (:form . "non-T-cells") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 140) (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 151)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s507.3) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004677@unknown@formal@none@1@S@HS I-III, located 5' from the transcriptional initiation site, were found in hematopoietic and non-hematopoietic cells, whereas HS IV-VII, located 3' from the transcriptional start site, were exclusively observed in T-cells.@(((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i-iii") (:form . "I-III") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 45) (:start . 30) (:id . 50))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 90) (:start . 77) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-hematopoietic") (:form . "non-hematopoietic")\n  (:end . 112) (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "iv-vii") (:form . "IV-VII") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 174) (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 180)\n  (:start . 175) (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 185) (:start . 181)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 191) (:start . 187)\n  (:id . 75))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 203)\n  (:start . 192) (:id . 76))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 212)\n  (:start . 204) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 223)\n  (:start . 216) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s507.4) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004678@unknown@formal@none@1@S@Among these hypersensitive sites, two transcriptional control elements were found, one in the first intron of the GATA-3 gene and the other between 8.3 and 5.9 kilobases 5' from the GATA-3 transcriptional initiation site.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 81) (:start . 76)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "CD") (:stem . "8.3") (:form . "8.3") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "CD") (:stem . "5.9") (:form . "5.9") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 169)\n  (:start . 160) (:id . 70))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 172) (:start . 171)\n  (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 177) (:start . 173)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 204) (:start . 189) (:id . 76))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 215)\n  (:start . 205) (:id . 77))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s507.5) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004680@unknown@formal@none@1@S@The upstream regulatory element could confer T-cell specificity to the GATA-3 promoter activity, and analysis of this region revealed a 707-base pair silencer that drastically inhibited GATA-3 promoter activity in non-T-cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "707-base") (:form . "707-base") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "RB") (:stem . "drastically") (:form . "drastically") (:end . 175)\n  (:start . 164) (:id . 67))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 192)\n  (:start . 186) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 201)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 210)\n  (:start . 202) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "non-t-cell") (:form . "non-T-cells") (:end . 225)\n  (:start . 214) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s507.7) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004681@unknown@formal@none@1@S@Two CAGGTG E-boxes, located at the 5'- and 3'-ends of the silencer, were necessary for this silencer activity.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CAGGTG") (:form . "CAGGTG") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NNPS") (:stem . "E-box") (:form . "E-boxes") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5'-") (:form . "5'-") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "3'-end") (:form . "3'-ends") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 82)\n  (:start . 73) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s507.8) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004682@unknown@formal@none@1@S@The 3'-CAGGTG E-box could bind USF proteins, the ubiquitous repressor ZEB, or the basic helix-loop-helix proteins E2A and HEB, and we showed that a competition between ZEB and E2A/HEB proteins is involved in the silencer activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "3'-CAGGTG") (:form . "3'-CAGGTG") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "E-box") (:form . "E-box") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "USF") (:form . "USF") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "zeb") (:form . "ZEB") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 104) (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HEB") (:form . "HEB") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 140)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 159)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 167)\n  (:start . 160) (:id . 70))\n ((:tag . "NNP") (:stem . "ZEB") (:form . "ZEB") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "E2A/HEB") (:form . "E2A/HEB") (:end . 183)\n  (:start . 176) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 192)\n  (:start . 184) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 204)\n  (:start . 196) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 78))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 220)\n  (:start . 212) (:id . 79))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s507.9) (:did . :|10037751|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004683@unknown@formal@none@1@S@AML and Ets proteins regulate the I alpha1 germ-line promoter.@(((:tag . "NNP") (:stem . "AML") (:form . "AML") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha1") (:form . "alpha1") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "germ-line") (:form . "germ-line") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s508.1) (:did . :|10064064|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004684@unknown@formal@none@1@S@The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 95) (:start . 81) (:id . 55))\n ((:tag . "VBZ") (:stem . "target") (:form . "targets") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 116)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "igh") (:form . "IgH") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "render") (:form . "rendered") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 176) (:start . 159) (:id . 65))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 183)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s508.2) (:did . :|10064064|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004685@unknown@formal@none@1@S@Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "germ-line") (:form . "germ-line") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "igh") (:form . "IgH") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "intervene") (:form . "intervening") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "i") (:form . "I") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 99)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s508.3) (:did . :|10064064|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004686@unknown@formal@none@1@S@The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha1") (:form . "alpha1") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "germ-line") (:form . "germ-line") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha1") (:form . "alpha1") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "iga1") (:form . "IgA1") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 121)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "TGF)-beta1") (:form . "TGF)-beta1") (:end . 147)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 162) (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 176)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s508.4) (:did . :|10064064|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004687@unknown@formal@none@1@S@Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha1") (:form . "alpha1") (:end . 30)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AML/PEBP2/CBF") (:form . "AML/PEBP2/CBF")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "AML") (:form . "AML") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 164)\n  (:start . 159) (:id . 68))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 175)\n  (:start . 165) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 188)\n  (:start . 183) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "tgf-beta-inducible") (:form . "TGF-beta-inducible")\n  (:end . 211) (:start . 193) (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 220)\n  (:start . 212) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 229)\n  (:start . 221) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s508.5) (:did . :|10064064|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004688@unknown@formal@none@1@S@Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "starting") (:form . "starting") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "IgA") (:form . "IgA") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s508.6) (:did . :|10064064|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004690@unknown@formal@none@1@S@Increased oxidative stress and subsequent activation of the transcription factor NF-kappaB has been linked to the development of late diabetic complications.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "diabetic") (:form . "diabetic") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "complication") (:form . "complications")\n  (:end . 156) (:start . 143) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s509.2) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004691@unknown@formal@none@1@S@To determine whether oxidative stress dependent NF-kappaB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kappaB activation in ex vivo isolated peripheral blood mononuclear cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "diabetic") (:form . "diabetic") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "nephropathy") (:form . "nephropathy") (:end . 117)\n  (:start . 106) (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 144) (:start . 129) (:id . 60))\n ((:tag . "NNP") (:stem . "Mobility") (:form . "Mobility") (:end . 153)\n  (:start . 145) (:id . 61))\n ((:tag . "NNP") (:stem . "Shift") (:form . "Shift") (:end . 159)\n  (:start . 154) (:id . 62))\n ((:tag . "NNP") (:stem . "Assay") (:form . "Assay") (:end . 165)\n  (:start . 160) (:id . 63))\n ((:tag . "JJ") (:stem . "based") (:form . "based") (:end . 171)\n  (:start . 166) (:id . 64))\n ((:tag . "JJ") (:stem . "semiquantitative") (:form . "semiquantitative")\n  (:end . 188) (:start . 172) (:id . 65))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 198)\n  (:start . 189) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 205)\n  (:start . 199) (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 211)\n  (:start . 206) (:id . 68))\n ((:tag . "VBD") (:stem . "enable") (:form . "enabled") (:end . 219)\n  (:start . 212) (:id . 69))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 222) (:start . 220)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 225) (:start . 223)\n  (:id . 71))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 235)\n  (:start . 226) (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 245)\n  (:start . 236) (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 256)\n  (:start . 246) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 259) (:start . 257)\n  (:id . 75))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 262) (:start . 260)\n  (:id . 76))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 267) (:start . 263)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 276)\n  (:start . 268) (:id . 78))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 287)\n  (:start . 277) (:id . 79))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 293)\n  (:start . 288) (:id . 80))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 305)\n  (:start . 294) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 311)\n  (:start . 306) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 312) (:start . 311)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x509.3.1) (:span 13 20)))\n (:hscopes ((:id . :x509.3.1) (:span 13 117)))\n (:identifiers (:sid . :s509.3) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004692@unknown@formal@none@1@S@We examined 33 patients with diabetes mellitus (Type I and Type II).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "diabetes") (:form . "diabetes") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "mellitus") (:form . "mellitus") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "Type") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Type") (:form . "Type") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s509.4) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004693@unknown@formal@none@1@S@Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications.@(((:tag . "NNS") (:stem . "patient") (:form . "Patients") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "diabetic") (:form . "diabetic") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "nephropathy") (:form . "nephropathy") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 41) (:start . 35)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 48) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 94) (:start . 79) (:id . 52))\n ((:tag . "NNP") (:stem . "Mobility") (:form . "Mobility") (:end . 103)\n  (:start . 95) (:id . 53))\n ((:tag . "NNP") (:stem . "Shift") (:form . "Shift") (:end . 109)\n  (:start . 104) (:id . 54))\n ((:tag . "NNPS") (:stem . "Assay") (:form . "Assays") (:end . 116)\n  (:start . 110) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 129)\n  (:start . 121) (:id . 57))\n ((:tag . "JJ") (:stem . "immunohistological") (:form . "immunohistological")\n  (:end . 148) (:start . 130) (:id . 58))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 157)\n  (:start . 149) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 161) (:start . 158)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 171)\n  (:start . 162) (:id . 61))\n ((:tag . "NN") (:stem . "nf-kappabp65") (:form . "NF-kappaBp65") (:end . 184)\n  (:start . 172) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 189) (:start . 185)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 198)\n  (:start . 190) (:id . 64))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 206)\n  (:start . 199) (:id . 65))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 212)\n  (:start . 207) (:id . 66))\n ((:tag . "NNS") (:stem . "complication") (:form . "complications")\n  (:end . 226) (:start . 213) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x509.5.1) (:span 199 206)))\n (:nscopes ((:id . :x509.5.1) (:span 199 226)))\n (:identifiers (:sid . :s509.5) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004694@unknown@formal@none@1@S@NF-kappaB binding activity correlated with the degree of albuminuria (r = 0.316) and with thrombomodulin plasma concentrations (r = 0.33), indicative for albuminuria associated endothelial dysfunction.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "albuminuria") (:form . "albuminuria") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "r") (:form . "r") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "CD") (:stem . "0.316") (:form . "0.316") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thrombomodulin") (:form . "thrombomodulin")\n  (:end . 104) (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 126) (:start . 112) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "r") (:form . "r") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "CD") (:stem . "0.33") (:form . "0.33") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "indicative") (:form . "indicative") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "albuminuria") (:form . "albuminuria") (:end . 165)\n  (:start . 154) (:id . 69))\n ((:tag . "JJ") (:stem . "associated") (:form . "associated") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 188)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "dysfunction") (:form . "dysfunction") (:end . 200)\n  (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s509.6) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004695@unknown@formal@none@1@S@In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (alpha-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48% and NF-kappaB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38%.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 10) (:start . 7)\n  (:id . 45))\n ((:tag . "NN") (:stem . "intervention") (:form . "intervention") (:end . 23)\n  (:start . 11) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . 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5004696@unknown@formal@none@1@S@In conclusion, activation of the transcription factor NF-kappaB in ex vivo isolated peripheral blood mononuclear cells of patients with diabetes mellitus correlates with the degree of diabetic nephropathy.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "diabetes") (:form . "diabetes") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "mellitus") (:form . "mellitus") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 164)\n  (:start . 154) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 180)\n  (:start . 174) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "diabetic") (:form . "diabetic") (:end . 192)\n  (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "nephropathy") (:form . "nephropathy") (:end . 204)\n  (:start . 193) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s509.8) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004697@unknown@formal@none@1@S@NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "thioctic") (:form . "thioctic") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "alpha-lipoic") (:end . 104)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s509.9) (:did . :|10064103|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004698@unknown@formal@none@1@S@Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 36) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "FW") (:stem . "gardnerella") (:form . "Gardnerella") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s510.1) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004700@unknown@formal@none@1@S@G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells.@(((:tag . "FW") (:stem . "g.") (:form . "G.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s510.3) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004701@unknown@formal@none@1@S@Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 36) (:start . 30)\n  (:id . 45))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "heat") (:form . "heated") (:end . 61) (:start . 55)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "c") (:form . "C") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lysozyme") (:form . "lysozyme") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s510.4) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004702@unknown@formal@none@1@S@G. vaginalis lysates also activated HIV expression in certain T cell lines.@(((:tag . "FW") (:stem . "g.") (:form . "G.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s510.5) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004703@unknown@formal@none@1@S@G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription.@(((:tag . "FW") (:stem . "g.") (:form . "G.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "long-terminal") (:form . "long-terminal")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 85)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 105)\n  (:start . 96) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 115)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 132)\n  (:start . 124) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 144)\n  (:start . 134) (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 154)\n  (:start . 148) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 62))\n ((:tag . "FW") (:stem . "g.") (:form . "G.") (:end . 160) (:start . 158)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 170)\n  (:start . 161) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 173) (:start . 171)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 177) (:start . 174)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x510.6.1) (:span 134 144)))\n (:hscopes ((:id . :x510.6.1) (:span 134 191)))\n (:identifiers (:sid . :s510.6) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004704@unknown@formal@none@1@S@The activation of HIV production by G. vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "FW") (:stem . "g.") (:form . "G.") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "genital") (:form . "genital") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "tract") (:form . "tract") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "FW") (:stem . "g.") (:form . "G.") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vaginalis") (:form . "vaginalis") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 143)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 157)\n  (:start . 147) (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "genital") (:form . "genital") (:end . 187)\n  (:start . 180) (:id . 70))\n ((:tag . "NN") (:stem . "tract") (:form . "tract") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x510.7.1) (:span 49 57)))\n (:hscopes ((:id . :x510.7.1) (:span 49 193)))\n (:identifiers (:sid . :s510.7) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004705@unknown@formal@none@1@S@This may explain, at least in part, the increased rate of HIV transmission in women with BV.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 49)\n  (:start . 40) (:id . 52))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 61) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 74)\n  (:start . 62) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "BV") (:form . "BV") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x510.8.1) (:span 5 8)))\n (:hscopes ((:id . :x510.8.1) (:span 5 91)))\n (:identifiers (:sid . :s510.8) (:did . :|10068588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004706@unknown@formal@none@1@S@Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.@(((:tag . "NNP") (:stem . "Interferon-alpha") (:form . "Interferon-alpha")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 35)\n  (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "upregulate") (:form . "upregulates") (:end . 65)\n  (:start . 54) (:id . 48))\n ((:tag . "JJ") (:stem . "proliferation-associated")\n  (:form . "proliferation-associated") (:end . 90) (:start . 66) (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 101)\n  (:start . 91) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 108)\n  (:start . 103) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pim-1") (:form . "pim-1") (:end . 119)\n  (:start . 114) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 125)\n  (:start . 120) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 134)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s511.1) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004707@unknown@formal@none@1@S@Interferon-alpha (IFN-alpha) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions.@(((:tag . "NNP") (:stem . "Interferon-alpha") (:form . "Interferon-alpha")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "antiproliferative") (:form . "antiproliferative")\n  (:end . 92) (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 114) (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s511.2) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004708@unknown@formal@none@1@S@There is increasing evidence that IFN-alpha has an important role in T-cell biology.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "biology") (:form . "biology") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x511.3.1) (:span 9 28)))\n (:hscopes ((:id . :x511.3.1) (:span 9 83)))\n (:identifiers (:sid . :s511.3) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004710@unknown@formal@none@1@S@The induction of these genes is associated with interleukin-2 (IL-2)-induced T-cell proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-2)-induced") (:form . "IL-2)-induced")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s511.5) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004711@unknown@formal@none@1@S@Treatment of T lymphocytes with IFN-alpha, IL-2, IL-12, and IL-15 upregulated IL-2Ralpha, c-myc, and pim-1 gene expression.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-15") (:form . "IL-15") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "upregulate") (:form . "upregulated") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pim-1") (:form . "pim-1") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s511.6) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004712@unknown@formal@none@1@S@IFN-alpha also sensitized T cells to IL-2-induced proliferation, further suggesting that IFN-alpha may be involved in the regulation of T-cell mitogenesis.@(((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "sensitize") (:form . "sensitized") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "mitogenesis") (:form . "mitogenesis") (:end . 154)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x511.7.1) (:span 99 102)) ((:id . :x511.7.2) (:span 73 83)))\n (:hscopes ((:id . :x511.7.1) (:span 89 154))\n  ((:id . :x511.7.2) (:span 73 154)))\n (:identifiers (:sid . :s511.7) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004713@unknown@formal@none@1@S@When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha, pim-1, and IRF-1 GAS elements after cytokine stimulation, we observed IFN-alpha-induced binding of STAT1, STAT3, and STAT4, but not STAT5 to all of these elements.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pim-1") (:form . "pim-1") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "JJ") (:stem . "ifn-alpha-induced") (:form . "IFN-alpha-induced")\n  (:end . 166) (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 174)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 190)\n  (:start . 185) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 201)\n  (:start . 196) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 206) (:start . 203)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 210) (:start . 207)\n  (:id . 79))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 216)\n  (:start . 211) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 81))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 223) (:start . 220)\n  (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 83))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 232)\n  (:start . 227) (:id . 84))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 241)\n  (:start . 233) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x511.8.1) (:span 207 210)))\n (:nscopes ((:id . :x511.8.1) (:span 207 216)))\n (:identifiers (:sid . :s511.8) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004714@unknown@formal@none@1@S@Yet, IFN-alpha was able to activate binding of STAT5 to the high-affinity IFP53 GAS site.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 14)\n  (:start . 5) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 73) (:start . 60) (:id . 54))\n ((:tag . "NNP") (:stem . "IFP53") (:form . "IFP53") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s511.9) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004715@unknown@formal@none@1@S@IFN-alpha enhanced tyrosine phosphorylation of STAT1, STAT3, STAT4, STAT5a, and STAT5b.@(((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 43) (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "STAT4") (:form . "STAT4") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "STAT5a") (:form . "STAT5a") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "STAT5b") (:form . "STAT5b") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s511.10) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004716@unknown@formal@none@1@S@IL-12 induced STAT4 and IL-2 and IL-15 induced STAT5 binding to the GAS elements.@(((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-15") (:form . "IL-15") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s511.11) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004717@unknown@formal@none@1@S@Taken together, our results suggest that IFN-alpha, IL-2, IL-12, and IL-15 have overlapping activities on human T cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-15") (:form . "IL-15") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 91)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 102)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x511.12.1) (:span 28 35)))\n (:hscopes ((:id . :x511.12.1) (:span 28 119)))\n (:identifiers (:sid . :s511.12) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004718@unknown@formal@none@1@S@These findings thus emphasize the importance of IFN-alpha as a T-cell regulatory cytokine.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "emphasize") (:form . "emphasize") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s511.13) (:did . :|10068671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004720@unknown@formal@none@1@S@NF-kappaB is a potent cellular activator of HIV-1 gene expression.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s512.2) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004721@unknown@formal@none@1@S@Down-regulation of NF-kappaB activation is known to inhibit HIV replication from the latently infected cells.@(((:tag . "NN") (:stem . "down-regulation") (:form . "Down-regulation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s512.3) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004722@unknown@formal@none@1@S@Gold compounds have been effectively used for many decades in the treatment of rheumatoid arthritis.@(((:tag . "NNP") (:stem . "Gold") (:form . "Gold") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "decade") (:form . "decades") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s512.4) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004723@unknown@formal@none@1@S@We previously reported that gold compounds, especially aurothioglucose (AuTG) containing monovalent gold ion, inhibited the DNA-binding of NF-kappaB in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gold") (:form . "gold") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "aurothioglucose") (:form . "aurothioglucose")\n  (:end . 70) (:start . 55) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AuTG") (:form . "AuTG") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "monovalent") (:form . "monovalent") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "gold") (:form . "gold") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s512.5) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004724@unknown@formal@none@1@S@In this report we have examined the efficacy of the gold compound AuTG as an inhibitor of HIV replication in latently infected OM10.1 and Ach2 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gold") (:form . "gold") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "autg") (:form . "AuTG") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 86)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "om10.1") (:form . "OM10.1") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ach2") (:form . "Ach2") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s512.6) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004725@unknown@formal@none@1@S@Tumor necrosis factor (TNF)-alpha-induced HIV-1 replication in OM10.1 or Ach2 cells was significantly inhibited by non-cytotoxic doses of AuTG (>10 microM in OM10.1 cells and >25 F.M in Ach2 cells), while 25 microM of the counter-anion thioglucose (TG) or gold compound containing divalent gold ion, HAuCl3, had no effect.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF)-alpha-induced") (:form . "TNF)-alpha-induced")\n  (:end . 41) (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "OM10.1") (:form . "OM10.1") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ach2") (:form . "Ach2") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 101) (:start . 88) (:id . 55))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "non-cytotoxic") (:form . 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5004726@unknown@formal@none@1@S@The effect of AuTG on NF-kappaB-dependent gene expression was confirmed by a transient CAT assay.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AuTG") (:form . "AuTG") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 41) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s512.8) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004727@unknown@formal@none@1@S@Specific staining as well as electron microscopic examinations revealed the accumulation of metal gold in the cells, supporting our previous hypothesis that gold ions could block NF-kappaB-DNA binding by a redox mechanism.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "electron") (:form . "electron") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "microscopic") (:form . "microscopic") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "examination") (:form . "examinations") (:end . 62)\n  (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 88)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "metal") (:form . "metal") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gold") (:form . "gold") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "support") (:form . "supporting") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 151)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gold") (:form . "gold") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "ion") (:form . "ions") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "nf-kappab-dna") (:form . "NF-kappaB-DNA")\n  (:end . 192) (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 200)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 205) (:start . 204)\n  (:id . 72))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 211)\n  (:start . 206) (:id . 73))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 221)\n  (:start . 212) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x512.9.1) (:span 141 151)))\n (:hscopes ((:id . :x512.9.1) (:span 141 221)))\n (:identifiers (:sid . :s512.9) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004728@unknown@formal@none@1@S@These observations indicate that the monovalent gold compound AuTG is a potentially useful drug for the treatment of patients infected with HIV.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monovalent") (:form . "monovalent") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "gold") (:form . "gold") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "AuTG") (:form . "AuTG") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x512.10.1) (:span 72 83))\n  ((:id . :x512.10.2) (:span 19 32)))\n (:hscopes ((:id . :x512.10.1) (:span 72 90))\n  ((:id . :x512.10.2) (:span 19 143)))\n (:identifiers (:sid . :s512.10) (:did . :|10069412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004730@unknown@formal@none@1@S@Allergen-specific T cells in atopic patients are polarized IL-4-producing Th2 cells, promoting IgE synthesis by B cells.@(((:tag . "JJ") (:stem . "allergen-specific") (:form . "Allergen-specific")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "polarize") (:form . "polarized") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "il-4-producing") (:form . "IL-4-producing")\n  (:end . 73) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s513.2) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004731@unknown@formal@none@1@S@The molecular basis for increased IL-4 gene expression in atopy is not fully understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "atopy") (:form . "atopy") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s513.3) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004732@unknown@formal@none@1@S@IL-4 gene regulation in general involves the nuclear factor of activated T cells (NFAT) family of transcription factors, of which NFAT1 and NFAT2 are most prominent in peripheral T cells.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "NNP") (:stem . "NFAT1") (:form . "NFAT1") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NFAT2") (:form . "NFAT2") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 164)\n  (:start . 155) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 180) (:start . 179)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s513.4) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004733@unknown@formal@none@1@S@Recently, a unique inhibitory role of NFAT1 in IL-4 gene control was shown in the mouse.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s513.5) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004734@unknown@formal@none@1@S@In a series of electrophoretic mobility shift assays with protein extracts of highly polarized Th2 clones from atopics and Th1 clones from controls we compared DNA-binding activities at the two NFAT-binding elements P0 and P1 of the crucial proximal human IL-4 promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 30) (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "VBN") (:stem . "polarize") (:form . "polarized") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "atopic") (:form . "atopics") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 171)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 182)\n  (:start . 172) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 193) (:start . 190)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nfat-binding") (:form . "NFAT-binding") (:end . 206)\n  (:start . 194) (:id . 72))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 215)\n  (:start . 207) (:id . 73))\n ((:tag . "NNP") (:stem . "P0") (:form . "P0") (:end . 218) (:start . 216)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p1") (:form . "P1") (:end . 225) (:start . 223)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 240)\n  (:start . 233) (:id . 79))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 249)\n  (:start . 241) (:id . 80))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 255)\n  (:start . 250) (:id . 81))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 260) (:start . 256)\n  (:id . 82))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 269)\n  (:start . 261) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s513.6) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004735@unknown@formal@none@1@S@At the most proximal P0 site, NFAT-containing complexes devoid of NFAT2 were readily inducible in the Th1 clones, but hardly or  not in the Th2 clones.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "p0") (:form . "P0") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nfat-containing") (:form . "NFAT-containing")\n  (:end . 45) (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "devoid") (:form . "devoid") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nfat2") (:form . "NFAT2") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "RB") (:stem . "hardly") (:form . "hardly") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x513.7.1) (:span 129 132)))\n (:nscopes ((:id . :x513.7.1) (:span 129 150)))\n (:identifiers (:sid . :s513.7) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004736@unknown@formal@none@1@S@In contrast, both in Th1 and Th2 clones NFAT-containing complexes were strongly inducible at the P1 site, consisting of NFAT2 and a P0-compatible NFAT activity, without apparent differences between Th1 and Th2 clones.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . "JJ") (:stem . "nfat-containing") (:form . "NFAT-containing")\n  (:end . 55) (:start . 40) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p1") (:form . "P1") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nfat2") (:form . "NFAT2") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "p0-compatible") (:form . "P0-compatible")\n  (:end . 145) (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 168)\n  (:start . 161) (:id . 70))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 189)\n  (:start . 178) (:id . 72))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 197)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 216)\n  (:start . 210) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x513.8.1) (:span 161 168)))\n (:nscopes ((:id . :x513.8.1) (:span 161 216)))\n (:identifiers (:sid . :s513.8) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004737@unknown@formal@none@1@S@Like in Th2 clones, suppressed NFAT-P0 complex formation was observed also at the polyclonal level in peripheral blood mononuclear cells (PBMC) of three of five severe atopic dermatitis patients with strongly elevated serum IgE levels, but not in control PBMC.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT-P0") (:form . "NFAT-P0") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 174)\n  (:start . 168) (:id . 71))\n ((:tag . "NN") (:stem . "dermatitis") (:form . "dermatitis") (:end . 185)\n  (:start . 175) (:id . 72))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 74))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 208)\n  (:start . 200) (:id . 75))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 217)\n  (:start . 209) (:id . 76))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 223)\n  (:start . 218) (:id . 77))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 227) (:start . 224)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 234)\n  (:start . 228) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 80))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 239) (:start . 236)\n  (:id . 81))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 243) (:start . 240)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 246) (:start . 244)\n  (:id . 83))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 254)\n  (:start . 247) (:id . 84))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 259) (:start . 255)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x513.9.1) (:span 240 243)))\n (:nscopes ((:id . :x513.9.1) (:span 240 259)))\n (:identifiers (:sid . :s513.9) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004738@unknown@formal@none@1@S@These findings suggest that high-level IL-4 production in atopic Th2 cells is associated with selective reduction of suppressive NFAT1 activity at the IL-4 P0 element and that some patients with this multifactorial disease may have a putative systemic disorder at this level.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 128)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p0") (:form . "P0") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 189)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 194) (:start . 190)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "multifactorial") (:form . "multifactorial")\n  (:end . 214) (:start . 200) (:id . 73))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 222)\n  (:start . 215) (:id . 74))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 226) (:start . 223)\n  (:id . 75))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 231) (:start . 227)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 233) (:start . 232)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 242)\n  (:start . 234) (:id . 78))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 251)\n  (:start . 243) (:id . 79))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 260)\n  (:start . 252) (:id . 80))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 263) (:start . 261)\n  (:id . 81))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 268) (:start . 264)\n  (:id . 82))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 274)\n  (:start . 269) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x513.10.1) (:span 234 242))\n  ((:id . :x513.10.2) (:span 223 226)) ((:id . :x513.10.3) (:span 15 22)))\n (:hscopes ((:id . :x513.10.1) (:span 234 260))\n  ((:id . :x513.10.2) (:span 223 274)) ((:id . :x513.10.3) (:span 15 274)))\n (:identifiers (:sid . :s513.10) (:did . :|10069428|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004740@unknown@formal@none@1@S@OBJECTIVE: The NF-kappa B/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 171) (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 177)\n  (:start . 172) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s514.2) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004741@unknown@formal@none@1@S@The aim of this study was to determine whether distinctive patterns of NF-kappa B activation are seen in different forms of joint disease.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "JJ") (:stem . "distinctive") (:form . "distinctive") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "joint") (:form . "joint") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x514.3.1) (:span 39 46)))\n (:hscopes ((:id . :x514.3.1) (:span 39 137)))\n (:identifiers (:sid . :s514.3) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004742@unknown@formal@none@1@S@METHODS: The DNA binding activity of these nucleoproteins was examined in purified synovial and peripheral T cells from patients with various chronic rheumatic diseases (12: four with rheumatoid arthritis; five with spondyloarthropathies; and three with osteoarthritis).@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "nucleoprotein") (:form . "nucleoproteins")\n  (:end . 57) (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "JJ") (:stem . "rheumatic") (:form . "rheumatic") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 204)\n  (:start . 195) (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 205) (:start . 204)\n  (:id . 74))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 210) (:start . 206)\n  (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 215) (:start . 211)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "spondyloarthropathy")\n  (:form . "spondyloarthropathies") (:end . 237) (:start . 216) (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 238) (:start . 237)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 79))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 248)\n  (:start . 243) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 253) (:start . 249)\n  (:id . 81))\n ((:tag . "NN") (:stem . "osteoarthritis") (:form . "osteoarthritis")\n  (:end . 268) (:start . 254) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 269) (:start . 268)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s514.4) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004743@unknown@formal@none@1@S@RESULTS: Electrophoretic mobility shift assays disclosed two specific complexes bound to a NF-kappa B specific 32P-labelled oligonucleotide in nucleoproteins extracted from purified T cells isolated from synovial fluid and peripheral blood of patients with rheumatoid arthritis.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "disclose") (:form . "disclosed") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "32p-labelled") (:form . "32P-labelled") (:end . 123)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 139) (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "nucleoprotein") (:form . "nucleoproteins")\n  (:end . 157) (:start . 143) (:id . 61))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 167)\n  (:start . 158) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 172) (:start . 168)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 181)\n  (:start . 173) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 183) (:start . 182)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 66))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 198)\n  (:start . 190) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 203) (:start . 199)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 212)\n  (:start . 204) (:id . 69))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 218)\n  (:start . 213) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 233)\n  (:start . 223) (:id . 72))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 239)\n  (:start . 234) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 242) (:start . 240)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 251)\n  (:start . 243) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 256) (:start . 252)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 267)\n  (:start . 257) (:id . 77))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 277)\n  (:start . 268) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s514.5) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004744@unknown@formal@none@1@S@The complexes consisted of p50/p50 homodimers and p50/p65 heterodimers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 70)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s514.6) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004745@unknown@formal@none@1@S@Increased NF-kappa B binding to DNA in synovial T cells was observed relative to peripheral T cells.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s514.7) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004746@unknown@formal@none@1@S@In non-rheumatoid arthritis, binding of NF-kappa B in synovial T cells was exclusively mediated by p50/p50 homodimers.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "non-rheumatoid") (:form . "non-rheumatoid")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s514.8) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004747@unknown@formal@none@1@S@CONCLUSION: Overall, the results suggest that NF-kappa B may play a central part in the activation of infiltrating T cells in chronic rheumatoid arthritis.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "overall") (:form . "Overall") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "infiltrate") (:form . "infiltrating") (:end . 114)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 133)\n  (:start . 126) (:id . 65))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 154)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x514.9.1) (:span 57 60)) ((:id . :x514.9.2) (:span 33 40)))\n (:hscopes ((:id . :x514.9.1) (:span 57 154))\n  ((:id . :x514.9.2) (:span 33 154)))\n (:identifiers (:sid . :s514.9) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004748@unknown@formal@none@1@S@The activation of this nuclear factor is qualitatively different in rheumatoid synovial T cells to that in other forms of non-rheumatoid arthritis (for example, osteoarthritis, spondyloarthropathies).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "qualitatively") (:form . "qualitatively")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "non-rheumatoid") (:form . "non-rheumatoid")\n  (:end . 136) (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "osteoarthritis") (:form . "osteoarthritis")\n  (:end . 175) (:start . 161) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "spondyloarthropathy")\n  (:form . "spondyloarthropathies") (:end . 198) (:start . 177) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s514.10) (:did . :|10070274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004750@unknown@formal@none@1@S@N-acetyl-L-cysteine (NAC) is an antioxidant molecule endowed with immunomodulatory properties.@(((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "VBN") (:stem . "endow") (:form . "endowed") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 82) (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s515.2) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004751@unknown@formal@none@1@S@To investigate the effect of NAC on the induction phase of T cell responses, we analyzed its action on human dendritic cells (DC) derived from adherent PBMC cultured with IL-4 and granulocyte-macrophage CSF.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 108)\n  (:start . 103) (:id . 62))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 118)\n  (:start . 109) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 137)\n  (:start . 130) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 151)\n  (:start . 143) (:id . 70))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 156) (:start . 152)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 165)\n  (:start . 157) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 175) (:start . 171)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 202) (:start . 180) (:id . 76))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSF") (:end . 206) (:start . 203)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s515.3) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004752@unknown@formal@none@1@S@We first found that NAC inhibited the constitutive as well as the LPS-induced activity of the transcription factor NF-kappaB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s515.4) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004753@unknown@formal@none@1@S@In parallel, NAC was shown to down-regulate the production of cytokines by DC as well as their surface expression of HLA-DR, CD86 (B7-2), and CD40 molecules both at the basal state and upon LPS activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VB") (:stem . "down-regulate") (:form . "down-regulate")\n  (:end . 43) (:start . 30) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 94)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 123)\n  (:start . 117) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CD86") (:form . "CD86") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B7-2") (:form . "B7-2") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 146) (:start . 142)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 156)\n  (:start . 147) (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 161) (:start . 157)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 164) (:start . 162)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 174)\n  (:start . 169) (:id . 76))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 180)\n  (:start . 175) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 78))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 189) (:start . 185)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 193) (:start . 190)\n  (:id . 80))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 204)\n  (:start . 194) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s515.5) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004754@unknown@formal@none@1@S@NAC also inhibited DC responses induced by CD40 engagement.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s515.6) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004755@unknown@formal@none@1@S@The inhibitory effects of NAC were not due to nonspecific toxicity as neither the viability of DC nor their mannose receptor-mediated endocytosis were modified by NAC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nonspecific") (:form . "nonspecific") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "mannose") (:form . "mannose") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "JJ") (:stem . "receptor-mediated") (:form . "receptor-mediated")\n  (:end . 133) (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x515.7.1) (:span 70 77 98 101))\n  ((:id . :x515.7.3) (:span 35 38)))\n (:nscopes ((:id . :x515.7.1) (:span 70 166))\n  ((:id . :x515.7.3) (:span 35 66)))\n (:identifiers (:sid . :s515.7) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004756@unknown@formal@none@1@S@Finally, we found that the addition of NAC to MLR between naive T cells and allogeneic DC resulted in a profound inhibition of alloreactive responses, which could be attributed to a defect of DC as APC-independent T cell responses were not inhibited by NAC.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MLR") (:form . "MLR") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 57)\n  (:start . 50) (:id . 53))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "allogeneic") (:form . "allogeneic") (:end . 86)\n  (:start . 76) (:id . 58))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 98)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 112)\n  (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 123)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "alloreactive") (:form . "alloreactive") (:end . 139)\n  (:start . 127) (:id . 66))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 176)\n  (:start . 166) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 194) (:start . 192)\n  (:id . 77))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 197) (:start . 195)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "apc-independent") (:form . "APC-independent")\n  (:end . 213) (:start . 198) (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 215) (:start . 214)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 220) (:start . 216)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 230)\n  (:start . 221) (:id . 82))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 235) (:start . 231)\n  (:id . 83))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 239) (:start . 236)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 249)\n  (:start . 240) (:id . 85))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 252) (:start . 250)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 256) (:start . 253)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x515.8.2) (:span 157 162)))\n (:ncues ((:id . :x515.8.1) (:span 236 239)))\n (:hscopes ((:id . :x515.8.2) (:span 151 194)))\n (:nscopes ((:id . :x515.8.1) (:span 198 256)))\n (:identifiers (:sid . :s515.8) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004757@unknown@formal@none@1@S@Altogether, our results suggest that NAC might impair the generation of primary immune responses in humans through its inhibitory action on DC.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "impair") (:form . "impair") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x515.9.1) (:span 41 46)) ((:id . :x515.9.2) (:span 24 31)))\n (:hscopes ((:id . :x515.9.1) (:span 41 142))\n  ((:id . :x515.9.2) (:span 24 142)))\n (:identifiers (:sid . :s515.9) (:did . :|10072497|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004758@unknown@formal@none@1@S@Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.@(((:tag . "JJ") (:stem . "bacterial") (:form . "Bacterial") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 28) (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 38)\n  (:start . 29) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 60) (:start . 47) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 68)\n  (:start . 61) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 82) (:start . 69) (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 92)\n  (:start . 83) (:id . 49))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 102)\n  (:start . 93) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 114)\n  (:start . 106) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 53))\n ((:tag . "JJ") (:stem . "dermal") (:form . "dermal") (:end . 127)\n  (:start . 121) (:id . 54))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 139)\n  (:start . 128) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 161)\n  (:start . 150) (:id . 58))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 172)\n  (:start . 162) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s516.1) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004760@unknown@formal@none@1@S@Activation of NF-kappaB is thought to be required for cytokine release from LPS-responsive cells, a critical step for endotoxic effects.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lps-responsive") (:form . "LPS-responsive")\n  (:end . 90) (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endotoxic") (:form . "endotoxic") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x516.3.1) (:span 27 34)))\n (:hscopes ((:id . :x516.3.1) (:span 0 135)))\n (:identifiers (:sid . :s516.3) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004761@unknown@formal@none@1@S@Here we investigated the role and involvement of interleukin-1 (IL-1) and tumor necrosis factor (TNF-alpha) signal transducer molecules in LPS signaling in human dermal microvessel endothelial cells (HDMEC) and THP-1 monocytic cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 152)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "JJ") (:stem . "dermal") (:form . "dermal") (:end . 168)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "microvessel") (:form . "microvessel") (:end . 180)\n  (:start . 169) (:id . 70))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 192)\n  (:start . 181) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 198)\n  (:start . 193) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 200) (:start . 199)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HDMEC") (:form . "HDMEC") (:end . 205)\n  (:start . 200) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 76))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 216)\n  (:start . 211) (:id . 77))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 226)\n  (:start . 217) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 232)\n  (:start . 227) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s516.4) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004762@unknown@formal@none@1@S@LPS stimulation of HDMEC and THP-1 cells initiated an IL-1 receptor-like NF-kappaB signaling cascade.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HDMEC") (:form . "HDMEC") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "initiate") (:form . "initiated") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "receptor-like") (:form . "receptor-like")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s516.5) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004763@unknown@formal@none@1@S@In transient cotransfection experiments, dominant negative mutants of the IL-1 signaling pathway, including MyD88, IRAK, IRAK2, and TRAF6 inhibited both IL-1- and LPS-induced NF-kappaB-luciferase activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "myd88") (:form . "MyD88") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IRAK2") (:form . "IRAK2") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TRAF6") (:form . "TRAF6") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IL-1-") (:form . "IL-1-") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 174)\n  (:start . 163) (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappaB-luciferase")\n  (:form . "NF-kappaB-luciferase") (:end . 195) (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 204)\n  (:start . 196) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s516.6) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004764@unknown@formal@none@1@S@LPS-induced NF-kappaB activation was not inhibited by a dominant negative mutant of TRAF2 that is involved in TNF signaling.@(((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x516.7.1) (:span 37 40)))\n (:nscopes ((:id . :x516.7.1) (:span 0 123)))\n (:identifiers (:sid . :s516.7) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004765@unknown@formal@none@1@S@LPS-induced activation of NF-kappaB-responsive reporter gene was not inhibited by IL-1 receptor antagonist.@(((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nf-kappab-responsive")\n  (:form . "NF-kappaB-responsive") (:end . 46) (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 55)\n  (:start . 47) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x516.8.1) (:span 65 68)))\n (:nscopes ((:id . :x516.8.1) (:span 0 106)))\n (:identifiers (:sid . :s516.8) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004766@unknown@formal@none@1@S@TLR2 and TLR4 were expressed on the cell surface of HDMEC and THP-1 cells.@(((:tag . "NNP") (:stem . "TLR2") (:form . "TLR2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TLR4") (:form . "TLR4") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HDMEC") (:form . "HDMEC") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s516.9) (:did . :|10075645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004767@unknown@formal@none@1@S@These findings suggest that a signal transduction molecule in the LPS receptor complex may belong to the IL-1 receptor/toll-like receptor (TLR) super family, and the LPS signaling cascade uses an analogous molecular framework for signaling as IL-1 in mononuclear phagocytes and endothelial cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "transduction") (:form . 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5004768@unknown@formal@none@1@S@Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.@(((:tag . "JJ") (:stem . "selective") (:form . "Selective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 48)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p38alpha") (:form . "p38alpha") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 78) (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 93)\n  (:start . 87) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 126) (:start . 97)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 138)\n  (:start . 127) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s517.1) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004770@unknown@formal@none@1@S@Lipopolysaccharide (LPS) stimulation of human neutrophils is known to result in activation of p38 mitogen-activated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and consequences of p38 MAPk activation remain largely undefined.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 115) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "activator(s)") (:form . "activator(s)") (:end . 173)\n  (:start . 161) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 196)\n  (:start . 189) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 214)\n  (:start . 202) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 221) (:start . 218)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 226) (:start . 222)\n  (:id . 80))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 237)\n  (:start . 227) (:id . 81))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 244)\n  (:start . 238) (:id . 82))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 252)\n  (:start . 245) (:id . 83))\n ((:tag . "JJ") (:stem . "undefined") (:form . "undefined") (:end . 262)\n  (:start . 253) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s517.3) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004771@unknown@formal@none@1@S@We investigated the MAPk kinase (MKK) that activates p38 MAPk in response to LPS, the p38 MAPk isoforms that are activated as part of this pathway, and the functional responses affected by p38 MAPk activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MKK") (:form . "MKK") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mapk") (:form . "MAPk") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 89) (:start . 86)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 94) (:start . 90)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 103)\n  (:start . 95) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 112) (:start . 109)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 122)\n  (:start . 113) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 130) (:start . 126)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 138) (:start . 134)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 146)\n  (:start . 139) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 166)\n  (:start . 156) (:id . 74))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 176)\n  (:start . 167) (:id . 75))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 185)\n  (:start . 177) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 192) (:start . 189)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 197) (:start . 193)\n  (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 208)\n  (:start . 198) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s517.4) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004772@unknown@formal@none@1@S@Although MKK3, MKK4, and MKK6 all activated p38 MAPk in experimental models, only MKK3 was found to activate recombinant p38 MAPk in LPS-treated neutrophils.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "MKK3") (:form . "MKK3") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MKK4") (:form . "MKK4") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MKK6") (:form . "MKK6") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 43)\n  (:start . 34) (:id . 50))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mapk") (:form . "MAPk") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 68)\n  (:start . 56) (:id . 54))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mkk3") (:form . "MKK3") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 96) (:start . 91)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 108)\n  (:start . 100) (:id . 62))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 120)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mapk") (:form . "MAPk") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lps-treated") (:form . "LPS-treated") (:end . 144)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 156)\n  (:start . 145) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s517.5) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004773@unknown@formal@none@1@S@Of p38 MAPk isoforms studied, only p38alpha and p38delta were detected in neutrophils.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p38alpha") (:form . "p38alpha") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p38delta") (:form . "p38delta") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s517.6) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004774@unknown@formal@none@1@S@LPS stimulation selectively activated p38alpha.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "p38alpha") (:form . "p38alpha") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s517.7) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5004777@unknown@formal@none@1@S@These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3, which in turn activates p38alpha MAPk, ultimately regulating adhesion, NF-kappaB activation, enhanced gene expression of TNF-alpha, and regulation of TNF-alpha synthesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MKK3") (:form . "MKK3") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 127)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "p38alpha") (:form . "p38alpha") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "MAPk") (:form . "MAPk") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 164)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 184)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 195)\n  (:start . 185) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 205)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 210) (:start . 206)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 234)\n  (:start . 225) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 79))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 250)\n  (:start . 240) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 253) (:start . 251)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 263)\n  (:start . 254) (:id . 82))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 273)\n  (:start . 264) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x517.10.1) (:span 15 22)))\n (:hscopes ((:id . :x517.10.1) (:span 15 102)))\n (:identifiers (:sid . :s517.10) (:did . :|10079106|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004778@unknown@formal@none@1@S@Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "il-4-inducible") (:form . "IL-4-inducible")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s518.1) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004780@unknown@formal@none@1@S@Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) inhibit induction of these genes by IL-4 and IL-13.@(((:tag . "NN") (:stem . "type") (:form . "Type") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s518.3) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004781@unknown@formal@none@1@S@However, the mechanism by which IFNs mediate this inhibition has not been defined.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ifn") (:form . "IFNs") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x518.4.1) (:span 65 68)))\n (:nscopes ((:id . :x518.4.1) (:span 9 81)))\n (:identifiers (:sid . :s518.4) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004782@unknown@formal@none@1@S@In this overview, we discuss the role of the transcription factor, STAT6 (signal transducer and activator of transcription-6) in mediating IL-4- and IL-13-induced gene expression in monocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overview") (:form . "overview") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 80)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 91)\n  (:start . 81) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription-6") (:form . "transcription-6")\n  (:end . 124) (:start . 109) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "il-4-") (:form . "IL-4-") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "il-13-induced") (:form . "IL-13-induced")\n  (:end . 162) (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s518.5) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004783@unknown@formal@none@1@S@We also discuss our recent findings that type I and type II IFNs suppress IL-4/IL-13-inducible gene expression by inhibiting tyrosine phosphorylation and nuclear translocation of STAT6.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "JJ") (:stem . "il-4/il-13-inducible")\n  (:form . "IL-4/IL-13-inducible") (:end . 94) (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 149) (:start . 134) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 175) (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 184)\n  (:start . 179) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s518.6) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004784@unknown@formal@none@1@S@The ability of type I and type II IFNs to inhibit IL-4/IL-13-induced STAT6 activity is dose- and time-dependent, and is not unique to monocytes because IFNs induce the same effects in fibroblasts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 49)\n  (:start . 42) (:id . 52))\n ((:tag . "JJ") (:stem . "il-4/il-13-induced") (:form . "IL-4/IL-13-induced")\n  (:end . 68) (:start . 50) (:id . 53))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dose-") (:form . "dose-") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 111) (:start . 97) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 143)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 163)\n  (:start . 157) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 180)\n  (:start . 173) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 195)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x518.7.1) (:span 120 123)))\n (:nscopes ((:id . :x518.7.1) (:span 120 143)))\n (:identifiers (:sid . :s518.7) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004785@unknown@formal@none@1@S@Inhibition of STAT6 activity is not evident unless cells are preincubated with IFN for at least 1 h before IL-4 stimulation.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x518.8.1) (:span 32 35)))\n (:nscopes ((:id . :x518.8.1) (:span 32 43)))\n (:identifiers (:sid . :s518.8) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004786@unknown@formal@none@1@S@Furthermore, inhibition can be blocked by actinomycin D, indicating a requirement for de novo transcription.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x518.9.1) (:span 57 67)))\n (:hscopes ((:id . :x518.9.1) (:span 57 107)))\n (:identifiers (:sid . :s518.9) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004787@unknown@formal@none@1@S@We propose a model in which stimulation of monocytes by IFN activates de novo synthesis of an inhibitory factor, possibly one or more members of the SOCS/ SSI/CIS gene family, capable of suppressing activation of STAT6 by IL-4 and IL-13.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "SOCS/") (:form . "SOCS/") (:end . 154)\n  (:start . 149) (:id . 69))\n ((:tag . "NNP") (:stem . "SSI/CIS") (:form . "SSI/CIS") (:end . 162)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 174)\n  (:start . 168) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 183)\n  (:start . 176) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 198)\n  (:start . 187) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 209)\n  (:start . 199) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 78))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 218)\n  (:start . 213) (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 221) (:start . 219)\n  (:id . 80))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 226) (:start . 222)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 82))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 236)\n  (:start . 231) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x518.10.1) (:span 126 128))\n  ((:id . :x518.10.2) (:span 113 121)))\n (:hscopes ((:id . :x518.10.1) (:span 122 133))\n  ((:id . :x518.10.2) (:span 113 174)))\n (:identifiers (:sid . :s518.10) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004788@unknown@formal@none@1@S@Because STAT6 activation plays an essential role in IL-4/IL-13-induced gene expression, the ability of IFN-beta and IFN-gamma to inhibit STAT6 activity provides an explanation for how IFNs can suppress IL-4/IL-13-inducible gene expression.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "il-4/il-13-induced") (:form . "IL-4/IL-13-induced")\n  (:end . 70) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 163) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 175)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "ifn") (:form . "IFNs") (:end . 188) (:start . 184)\n  (:id . 69))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 201)\n  (:start . 193) (:id . 71))\n ((:tag . "JJ") (:stem . "il-4/il-13-inducible")\n  (:form . "IL-4/IL-13-inducible") (:end . 222) (:start . 202) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 227) (:start . 223)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 238)\n  (:start . 228) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s518.11) (:did . :|10080532|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004790@unknown@formal@none@1@S@A region between-3134 and -2729 bp upstream from the transcription site of the human pro-interleukin 1beta (proIL-1beta) gene was identified as an LPS-responsive enhancer element.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "CD") (:stem . "between-3134") (:form . "between-3134") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-2729") (:form . "-2729") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pro-interleukin") (:form . "pro-interleukin")\n  (:end . 100) (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proil-1beta") (:form . "proIL-1beta") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lps-responsive") (:form . "LPS-responsive")\n  (:end . 161) (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s519.2) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004791@unknown@formal@none@1@S@In this study, the influence of the sequences located between -3134 and -2987 on the transcriptional activity of the proIL-1beta gene in LPS-stimulated Raw 264.7 cells was examined in detail.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "CD") (:stem . "-3134") (:form . "-3134") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-2987") (:form . "-2987") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proil-1beta") (:form . "proIL-1beta") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 151) (:start . 137) (:id . 65))\n ((:tag . "NNP") (:stem . "Raw") (:form . "Raw") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 180)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 190)\n  (:start . 184) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s519.3) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004792@unknown@formal@none@1@S@The results obtained by transient transfection of fos -CAT constructs that contained serial 5'-deletion mutations showed that the region between -3134 and -3059 appears to be required for the induction of transcription by LPS.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "-CAT") (:form . "-CAT") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "serial") (:form . "serial") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "5'-deletion") (:form . "5'-deletion") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 120)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 136)\n  (:start . 130) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . "CD") (:stem . "-3134") (:form . "-3134") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-3059") (:form . "-3059") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 168)\n  (:start . 161) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 183)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 201)\n  (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 218) (:start . 205) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 221) (:start . 219)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 225) (:start . 222)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x519.4.1) (:span 161 168)))\n (:hscopes ((:id . :x519.4.1) (:span 126 225)))\n (:identifiers (:sid . :s519.4) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004793@unknown@formal@none@1@S@Gel shift assay studies with synthetic oligonucleotides corresponding to partial sequences of the latter region and nuclear extracts from stimulated cells revealed specific protein binding sites between -3110 and -3090 and between -3079 and -3059.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 55) (:start . 39) (:id . 48))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 69)\n  (:start . 56) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 148)\n  (:start . 138) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 62))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 163)\n  (:start . 155) (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 172)\n  (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 180)\n  (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 188)\n  (:start . 181) (:id . 66))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 194)\n  (:start . 189) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 202)\n  (:start . 195) (:id . 68))\n ((:tag . "CD") (:stem . "-3110") (:form . "-3110") (:end . 208)\n  (:start . 203) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 70))\n ((:tag . "CD") (:stem . "-3090") (:form . "-3090") (:end . 218)\n  (:start . 213) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 72))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 230)\n  (:start . 223) (:id . 73))\n ((:tag . "CD") (:stem . "-3079") (:form . "-3079") (:end . 236)\n  (:start . 231) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 75))\n ((:tag . "CD") (:stem . "-3059") (:form . "-3059") (:end . 246)\n  (:start . 241) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s519.5) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004794@unknown@formal@none@1@S@These specific bindings were time and LPS dose dependent.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "binding") (:form . "bindings") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s519.6) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004795@unknown@formal@none@1@S@The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF-kappaB components p50 and p65, and did not contain other NF-kappaB proteins (p52, c-Rel, Rel B), AP-1 proteins (c-Fos, C-Jun), CREB or C/EBPbeta (NF-IL6).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . 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5004796@unknown@formal@none@1@S@Mutation of either of the putative NF-kappaB-binding sites in the enhancer element decreased the LPS-stimulated transcriptional activity.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 52) (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 111) (:start . 97) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 127) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s519.8) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004797@unknown@formal@none@1@S@These data indicated that two NF-kappaB-binding sites, which are located between -3134 and -3059, are critical for the activation of proIL-1beta gene transcription.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 47) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "CD") (:stem . "-3134") (:form . "-3134") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-3059") (:form . "-3059") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "proil-1beta") (:form . "proIL-1beta") (:end . 144)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 163) (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x519.9.1) (:span 11 25)))\n (:hscopes ((:id . :x519.9.1) (:span 11 163)))\n (:identifiers (:sid . :s519.9) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004798@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s519.10) (:did . :|10080875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004800@unknown@formal@none@1@S@TRAF2 is a signal transducing adaptor molecule which binds to the CD40 cytoplasmic domain.@(((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "transducing") (:form . "transducing") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s520.2) (:did . :|10080948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004801@unknown@formal@none@1@S@We have found that it is phosphorylated, predominantly on serine residues, when transiently overexpressed in 293 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 39) (:start . 25) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s520.3) (:did . :|10080948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004802@unknown@formal@none@1@S@The phosphorylation appears to be related to the signaling events that are activated by TRAF2 under these circumstances, since two nonfunctional mutants were found to be phosphorylated significantly less than the wild-type protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 119) (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nonfunctional") (:form . "nonfunctional")\n  (:end . 144) (:start . 131) (:id . 63))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 184) (:start . 170) (:id . 69))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 203) (:start . 199)\n  (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 208) (:start . 204)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 222)\n  (:start . 213) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 230)\n  (:start . 223) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x520.4.1) (:span 20 27)))\n (:hscopes ((:id . :x520.4.1) (:span 0 119)))\n (:identifiers (:sid . :s520.4) (:did . :|10080948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004803@unknown@formal@none@1@S@Furthermore, the phosphorylation status of TRAF2 had significant effects on the ability of the protein to bind to CD40, as evidenced by our observations that the CD40 cytoplasmic domain interacted preferentially with underphosphorylated TRAF2 and that phosphatase treatment significantly enhanced the binding of TRAF2 to CD40.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . 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5004804@unknown@formal@none@1@S@We conclude from these studies that the phosphorylation of TRAF2 is likely to play an important role in regulating signaling by virtue of its ability to influence the CD40-TRAF2 interaction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "virtue") (:form . "virtue") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 162)\n  (:start . 153) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cd40-traf2") (:form . "CD40-TRAF2") (:end . 177)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 189)\n  (:start . 178) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x520.6.1) (:span 68 74)))\n (:hscopes ((:id . :x520.6.1) (:span 36 189)))\n (:identifiers (:sid . :s520.6) (:did . :|10080948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004805@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s520.7) (:did . :|10080948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004806@unknown@formal@none@1@S@Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist.@(((:tag . "NNP") (:stem . "Cobalt") (:form . "Cobalt") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chloride-induced") (:form . "chloride-induced")\n  (:end . 23) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 33)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 56)\n  (:start . 49) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "augmented") (:form . "augmented") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 130) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 140)\n  (:start . 131) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monocyte-like") (:form . "monocyte-like")\n  (:end . 157) (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 163)\n  (:start . 158) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 169)\n  (:start . 164) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 180)\n  (:start . 173) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 183) (:start . 181)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PAF-receptor") (:form . "PAF-receptor")\n  (:end . 196) (:start . 184) (:id . 67))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 207)\n  (:start . 197) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s521.1) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004807@unknown@formal@none@1@S@In response to hypoxia, sickle red blood cells (SS RBC) and leukocytes exhibit increased adherence to the vascular endothelium, while diapedesis of leukocytes through the blood vessel increases.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 70)\n  (:start . 60) (:id . 56))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 88)\n  (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "diapedesis") (:form . "diapedesis") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 158)\n  (:start . 148) (:id . 68))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "vessel") (:form . "vessel") (:end . 183)\n  (:start . 177) (:id . 72))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 193)\n  (:start . 184) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s521.2) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004808@unknown@formal@none@1@S@However, the cellular signaling pathway(s) caused by hypoxia is poorly understood.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "pathway(s)") (:form . "pathway(s)") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s521.3) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004810@unknown@formal@none@1@S@We found that in human umbilical vein endothelial cells (HUVEC), CoCl2 at 2 mM concentration induced the surface expression of a subset of CAMs (VCAM-1) and activation of transcription factor NF-kappaB in the nuclear extracts of HUVEC.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cocl2") (:form . "CoCl2") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mm") (:form . "mM") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 92) (:start . 79) (:id . 59))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 100)\n  (:start . 93) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 135)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CAM") (:form . "CAMs") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 151)\n  (:start . 145) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 167)\n  (:start . 157) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 184) (:start . 171) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 191)\n  (:start . 185) (:id . 76))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 201)\n  (:start . 192) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 216)\n  (:start . 209) (:id . 80))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 225)\n  (:start . 217) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 234)\n  (:start . 229) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s521.5) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004811@unknown@formal@none@1@S@Furthermore, CoCl2 also caused time-dependent tyrosine phosphorylation of mitogen-activated protein (MAP) kinase isoform ERK2 without significantly affecting ERK1, indicating ERK2 is the preferred substrate for upstream kinase of the MAPK pathway.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CoCl2") (:form . "CoCl2") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 45) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 70) (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 91) (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 112)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "erk2") (:form . "ERK2") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 133)\n  (:start . 126) (:id . 59))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 147) (:start . 134) (:id . 60))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 157)\n  (:start . 148) (:id . 61))\n ((:tag . "NN") (:stem . "erk1") (:form . "ERK1") (:end . 162) (:start . 158)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 174)\n  (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "erk2") (:form . "ERK2") (:end . 179) (:start . 175)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 182) (:start . 180)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "prefer") (:form . "preferred") (:end . 196)\n  (:start . 187) (:id . 68))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 206)\n  (:start . 197) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 210) (:start . 207)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 219)\n  (:start . 211) (:id . 71))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 226)\n  (:start . 220) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 233) (:start . 230)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 238) (:start . 234)\n  (:id . 75))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 246)\n  (:start . 239) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x521.6.1) (:span 164 174)))\n (:ncues ((:id . :x521.6.2) (:span 126 133)))\n (:hscopes ((:id . :x521.6.1) (:span 164 246)))\n (:nscopes ((:id . :x521.6.2) (:span 126 162)))\n (:identifiers (:sid . :s521.6) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004812@unknown@formal@none@1@S@Inhibitors of MAP kinase (PD98059) or platelet-activating factor (PAF)- receptor antagonist (CV3988) inhibited the CoCl2-induced NF-kappaB activation and VCAM-1 expression.@(((:tag . "NNS") (:stem . "inhibitor") (:form . "Inhibitors") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PD98059") (:form . "PD98059") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 57) (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "PAF)-") (:form . "PAF)-") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cv3988") (:form . "CV3988") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cocl2-induced") (:form . "CoCl2-induced")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s521.7) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004813@unknown@formal@none@1@S@Augmented expression of VCAM-1 led to increased SS RBC adhesion, inhibitable by a VCAM-1 antibody.@(((:tag . "JJ") (:stem . "augmented") (:form . "Augmented") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inhibitable") (:form . "inhibitable") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s521.8) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004814@unknown@formal@none@1@S@Additionally, CoCl2 caused a two- to threefold increase in the rate of transendothelial migration of monocyte-like HL-60 cells and a twentyfold increase in phosphorylation of platelet endothelial cell adhesion molecules (PECAM-1).@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CoCl2") (:form . "CoCl2") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "threefold") (:form . "threefold") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 87) (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocyte-like") (:form . "monocyte-like")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "twentyfold") (:form . "twentyfold") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 171) (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 183)\n  (:start . 175) (:id . 68))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 195)\n  (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 209)\n  (:start . 201) (:id . 71))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 219)\n  (:start . 210) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 221) (:start . 220)\n  (:id . 73))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 228)\n  (:start . 221) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 229) (:start . 228)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s521.9) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004815@unknown@formal@none@1@S@The transendothelial migration of monocytes was inhibited by an antibody to PECAM-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s521.10) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004816@unknown@formal@none@1@S@Both phosphorylation of PECAM-1 and transendothelial migration of monocytes in response to CoCl2 were inhibited by protein kinase inhibitor (GF109203X) and augmented by protein phosphatase inhibitor (Calyculin A).@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 52) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CoCl2") (:form . "CoCl2") (:end . 96) (:start . 91)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "GF109203X") (:form . "GF109203X") (:end . 150)\n  (:start . 141) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "augment") (:form . "augmented") (:end . 165)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 188)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 198)\n  (:start . 189) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 200) (:start . 199)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Calyculin") (:form . "Calyculin") (:end . 209)\n  (:start . 200) (:id . 71))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 211) (:start . 210)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s521.11) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004817@unknown@formal@none@1@S@Our data suggests that CoCl2-induced cellular signals directing increased expression of VCAM-1 in HUVEC involve downstream activation of MAP kinase and NF-kappaB, while the phosphorylation of PECAM-1 occurs as a result of activation of PKC.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cocl2-induced") (:form . "CoCl2-induced")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 103)\n  (:start . 98) (:id . 55))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 147)\n  (:start . 141) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 161)\n  (:start . 152) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 64))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 168)\n  (:start . 163) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 188) (:start . 173) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 199)\n  (:start . 192) (:id . 69))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 206)\n  (:start . 200) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 209) (:start . 207)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 211) (:start . 210)\n  (:id . 72))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 218)\n  (:start . 212) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 232)\n  (:start . 222) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 239) (:start . 236)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x521.12.1) (:span 9 17)))\n (:hscopes ((:id . :x521.12.1) (:span 9 239)))\n (:identifiers (:sid . :s521.12) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004818@unknown@formal@none@1@S@We conclude that PAF-receptor antagonist inhibits the CoCl2- or hypoxia-induced increase in the adhesion of SS RBC, PECAM-1 phosphorylation, and the concomitant transendothelial migration of monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PAF-receptor") (:form . "PAF-receptor") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cocl2-") (:form . "CoCl2-") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hypoxia-induced") (:form . "hypoxia-induced")\n  (:end . 79) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 139) (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 160)\n  (:start . 149) (:id . 65))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 177) (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 187)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 200)\n  (:start . 191) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s521.13) (:did . :|10082134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004820@unknown@formal@none@1@S@Previous studies have implicated a role for intracellular thiols in the activation of nuclear factor-kappaB and transcriptional regulation of endothelial cell adhesion molecules.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "thiol") (:form . "thiols") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 127) (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 153)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 158) (:start . 154)\n  (:id . 62))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 167)\n  (:start . 159) (:id . 63))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 177)\n  (:start . 168) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s522.2) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004821@unknown@formal@none@1@S@This study was designed to determine whether changes in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesivity and to define the molecular mechanism that underlies this GSSG/GSH-induced adhesion response.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 142)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "adhesivity") (:form . "adhesivity") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 181)\n  (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 196) (:start . 192)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "underlie") (:form . "underlies") (:end . 206)\n  (:start . 197) (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 211) (:start . 207)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "gssg/gsh-induced") (:form . "GSSG/GSH-induced")\n  (:end . 228) (:start . 212) (:id . 76))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 237)\n  (:start . 229) (:id . 77))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 246)\n  (:start . 238) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x522.3.1) (:span 91 93)) ((:id . :x522.3.2) (:span 37 44)))\n (:hscopes ((:id . :x522.3.1) (:span 56 121))\n  ((:id . :x522.3.2) (:span 37 153)))\n (:identifiers (:sid . :s522.3) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004822@unknown@formal@none@1@S@Treatment of human umbilical vein endothelial cell (HUVEC) monolayers for 6 hours with 0.2 mmol/L diamide and 1 mmol/L buthionine sulfoximine (BSO) decreased GSH levels and increased the ratio of GSSG to GSH without cell toxicity.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monolayer") (:form . "monolayers") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mmol/l") (:form . "mmol/L") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "diamide") (:form . "diamide") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mmol/l") (:form . "mmol/L") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "buthionine") (:form . "buthionine") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "sulfoximine") (:form . "sulfoximine") (:end . 141)\n  (:start . 130) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BSO") (:form . "BSO") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 157)\n  (:start . 148) (:id . 68))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 168)\n  (:start . 162) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 192)\n  (:start . 187) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gssg") (:form . "GSSG") (:end . 200) (:start . 196)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 215)\n  (:start . 208) (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 220) (:start . 216)\n  (:id . 80))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 229)\n  (:start . 221) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x522.4.1) (:span 208 215)))\n (:nscopes ((:id . :x522.4.1) (:span 208 229)))\n (:identifiers (:sid . :s522.4) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004823@unknown@formal@none@1@S@These redox changes are similar to those observed with anoxia/reoxygenation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "anoxia/reoxygenation")\n  (:form . "anoxia/reoxygenation") (:end . 75) (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s522.5) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004824@unknown@formal@none@1@S@Diamide plus BSO-induced thiol/disulfide imbalance was associated with a biphasic increase in neutrophil adhesion to HUVECs with peak responses observed at 15 minutes (phase 1) and 240 minutes (phase 2).@(((:tag . "NNP") (:stem . "Diamide") (:form . "Diamide") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "bso-induced") (:form . "BSO-induced") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "thiol/disulfide") (:form . "thiol/disulfide")\n  (:end . 40) (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "imbalance") (:form . "imbalance") (:end . 50)\n  (:start . 41) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 65)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 113)\n  (:start . 105) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 123)\n  (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 143)\n  (:start . 134) (:id . 60))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 155) (:start . 153)\n  (:id . 62))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 173)\n  (:start . 168) (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 175) (:start . 174)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "CD") (:stem . "240") (:form . "240") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 199)\n  (:start . 194) (:id . 73))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 201) (:start . 200)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s522.6) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004825@unknown@formal@none@1@S@N-Acetylcysteine treatment attenuated neutrophil adhesion in both phases, which indicated a role for GSH in the adhesion responses.@(((:tag . "NNP") (:stem . "N-Acetylcysteine") (:form . "N-Acetylcysteine")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 37)\n  (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 48)\n  (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 57)\n  (:start . 49) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 65) (:start . 61)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 72)\n  (:start . 66) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s522.7) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004826@unknown@formal@none@1@S@Interestingly, phase 1 adhesion was inversely correlated with GSH levels but not with the GSSG/GSH ratio, whereas phase 2 neutrophil adhesion was positively correlated with GSSG/GSH ratio but not with GSH levels.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "inversely") (:form . "inversely") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gssg/gsh") (:form . "GSSG/GSH") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 167)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gssg/gsh") (:form . "GSSG/GSH") (:end . 181)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 187)\n  (:start . 182) (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 211)\n  (:start . 205) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x522.8.1) (:span 192 195))\n  ((:id . :x522.8.2) (:span 77 80)))\n (:nscopes ((:id . :x522.8.1) (:span 192 211))\n  ((:id . :x522.8.2) (:span 77 104)))\n (:identifiers (:sid . :s522.8) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004827@unknown@formal@none@1@S@Intercellular adhesion molecule-1 and P-selectin-specific monoclonal antibodies attenuated the increased neutrophil adhesion during both phases, whereas an anti-E-selectin monoclonal antibody also attenuated the phase 2 response.@(((:tag . "JJ") (:stem . "intercellular") (:form . "Intercellular")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 33)\n  (:start . 23) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "p-selectin-specific")\n  (:form . "P-selectin-specific") (:end . 57) (:start . 38) (:id . 46))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 68)\n  (:start . 58) (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 79)\n  (:start . 69) (:id . 48))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 90)\n  (:start . 80) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 104)\n  (:start . 95) (:id . 51))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 115)\n  (:start . 105) (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 124)\n  (:start . 116) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 131)\n  (:start . 125) (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 136) (:start . 132)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 143)\n  (:start . 137) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 57))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 152)\n  (:start . 145) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 155) (:start . 153)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-e-selectin") (:form . "anti-E-selectin")\n  (:end . 171) (:start . 156) (:id . 60))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 182)\n  (:start . 172) (:id . 61))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 191)\n  (:start . 183) (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 196) (:start . 192)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 207)\n  (:start . 197) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 217)\n  (:start . 212) (:id . 66))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 219) (:start . 218)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 228)\n  (:start . 220) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s522.9) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004828@unknown@formal@none@1@S@Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides that contained nuclear factor-kappaB or activator protein-1 cognate DNA sequences significantly attenuated the phase 2 response, which implicated a role for de novo protein synthesis.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "compete") (:form . "competing") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "ds-oligonucleotide")\n  (:form . "ds-oligonucleotides") (:end . 87) (:start . 68) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 102)\n  (:start . 93) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 54))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 124) (:start . 111) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 137)\n  (:start . 128) (:id . 57))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 147)\n  (:start . 138) (:id . 58))\n ((:tag . "NN") (:stem . "cognate") (:form . "cognate") (:end . 155)\n  (:start . 148) (:id . 59))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 159) (:start . 156)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 169)\n  (:start . 160) (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 183) (:start . 170) (:id . 62))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 194)\n  (:start . 184) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 204)\n  (:start . 199) (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 206) (:start . 205)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 215)\n  (:start . 207) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 222)\n  (:start . 217) (:id . 69))\n ((:tag . "VBD") (:stem . "implicate") (:form . "implicated") (:end . 233)\n  (:start . 223) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 235) (:start . 234)\n  (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 240) (:start . 236)\n  (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 244) (:start . 241)\n  (:id . 73))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 247) (:start . 245)\n  (:id . 74))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 252) (:start . 248)\n  (:id . 75))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 260)\n  (:start . 253) (:id . 76))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 270)\n  (:start . 261) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s522.10) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004830@unknown@formal@none@1@S@This study demonstrates that changes in endothelial cell GSSG/GSH cause transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules, which leads to a 2-phase neutrophil-endothelial adhesion response.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gssg/gsh") (:form . "GSSG/GSH") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcription-independent")\n  (:form . "transcription-independent") (:end . 97) (:start . 72) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcription-dependent")\n  (:form . "transcription-dependent") (:end . 125) (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 133)\n  (:start . 126) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 157)\n  (:start . 148) (:id . 58))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 169)\n  (:start . 158) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 174) (:start . 170)\n  (:id . 60))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 183)\n  (:start . 175) (:id . 61))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 193)\n  (:start . 184) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 200)\n  (:start . 195) (:id . 64))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 206)\n  (:start . 201) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 211) (:start . 210)\n  (:id . 67))\n ((:tag . "NN") (:stem . "2-phase") (:form . "2-phase") (:end . 219)\n  (:start . 212) (:id . 68))\n ((:tag . "JJ") (:stem . "neutrophil-endothelial")\n  (:form . "neutrophil-endothelial") (:end . 242) (:start . 220) (:id . 69))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 251)\n  (:start . 243) (:id . 70))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 260)\n  (:start . 252) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s522.12) (:did . :|10082473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004831@unknown@formal@none@1@S@Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence.@(((:tag . "VBN") (:stem . "decrease") (:form . "Decreased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "proteasome-mediated")\n  (:form . "proteasome-mediated") (:end . 29) (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 41)\n  (:start . 30) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 46) (:start . 45)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "senescence") (:form . "senescence") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s523.1) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004832@unknown@formal@none@1@S@Induction of NFkappaB is a highly regulated process requiring phosphorylation, ubiquitination, and proteasome-mediated degradation of the cytosolic inhibitor IkappaBalpha.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 77) (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 93) (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proteasome-mediated")\n  (:form . "proteasome-mediated") (:end . 118) (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 130)\n  (:start . 119) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 147)\n  (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 157)\n  (:start . 148) (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 170) (:start . 158) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s523.2) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004833@unknown@formal@none@1@S@Analyses of the regulation of IkappaBalpha in TNF-alpha-treated T lymphocytes from young and elderly donors revealed severely compromised degradation of IkappaBalpha in T cells from the elderly.@(((:tag . "NNS") (:stem . "analysis") (:form . "Analyses") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tnf-alpha-treated") (:form . "TNF-alpha-treated")\n  (:end . 63) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "VBN") (:stem . "compromise") (:form . "compromised") (:end . 137)\n  (:start . 126) (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 149)\n  (:start . 138) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 165) (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 170) (:start . 169)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 181) (:start . 177)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 193)\n  (:start . 186) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s523.3) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004834@unknown@formal@none@1@S@Examination of activation-induced phosphorylation and ubiquitination of IkappaBalpha did not demonstrate any significant age-related alterations.@(((:tag . "NNP") (:stem . "Examination") (:form . "Examination") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 33) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 49) (:start . 34) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 68) (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 84)\n  (:start . 72) (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 88) (:start . 85)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 51))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 104)\n  (:start . 93) (:id . 52))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 108) (:start . 105)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 120)\n  (:start . 109) (:id . 54))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 132)\n  (:start . 121) (:id . 55))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 144)\n  (:start . 133) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x523.4.1) (:span 89 92)))\n (:nscopes ((:id . :x523.4.1) (:span 0 144)))\n (:identifiers (:sid . :s523.4) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004835@unknown@formal@none@1@S@However, examination of proteasome activity in these T cells using fluorogenic peptide assays revealed a significant age-related decline in chymotryptic activity.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "examination") (:form . "examination") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fluorogenic") (:form . "fluorogenic") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 116)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 128)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "chymotryptic") (:form . "chymotryptic") (:end . 152)\n  (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 161)\n  (:start . 153) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s523.5) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004836@unknown@formal@none@1@S@These results suggest that a decline in proteasome activity results in a failure to fully degrade IkappaBalpha in the elderly.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "VB") (:stem . "degrade") (:form . "degrade") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 110) (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x523.6.1) (:span 14 21)))\n (:hscopes ((:id . :x523.6.1) (:span 14 125)))\n (:identifiers (:sid . :s523.6) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004837@unknown@formal@none@1@S@This failure to degrade IkappaBalpha may underlie both the observed decrease in NFkappaB induction and the IL-2 receptor expression in TNF-treated T cells during aging.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "degrade") (:form . "degrade") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "tnf-treated") (:form . "TNF-treated") (:end . 146)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 167)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x523.7.1) (:span 37 40)))\n (:hscopes ((:id . :x523.7.1) (:span 37 167)))\n (:identifiers (:sid . :s523.7) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004838@unknown@formal@none@1@S@Thus, decreased proteasome-mediated degradation may be central to immune dysfunction that accompanies aging.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "JJ") (:stem . "proteasome-mediated")\n  (:form . "proteasome-mediated") (:end . 35) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "dysfunction") (:form . "dysfunction") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "accompany") (:form . "accompanies") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x523.8.1) (:span 48 51)))\n (:hscopes ((:id . :x523.8.1) (:span 48 107)))\n (:identifiers (:sid . :s523.8) (:did . :|10087185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004840@unknown@formal@none@1@S@Identification of upstream regulatory elements that repress expression of adult beta-like globin genes in a primitive erythroid environment.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "repress") (:form . "repress") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "beta-like") (:form . "beta-like") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 96)\n  (:start . 90) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 127)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 139)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s524.1) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004841@unknown@formal@none@1@S@Our investigations have focused on localizing cis-elements responsible for the down regulation of the adult beta-like globin genes (delta and beta) in immature, or primitive erythroid tissues.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "investigation") (:form . "investigations")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "localize") (:form . "localizing") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 58)\n  (:start . 46) (:id . 48))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 70)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "down") (:form . "down") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "beta-like") (:form . "beta-like") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 173)\n  (:start . 164) (:id . 69))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 183)\n  (:start . 174) (:id . 70))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s524.2) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004842@unknown@formal@none@1@S@We studied their activity after transfection into K562 cells, an erythroleukemia cell line with an embryonic-fetal phenotype.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 16)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 80) (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "embryonic-fetal") (:form . "embryonic-fetal")\n  (:end . 114) (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s524.3) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004843@unknown@formal@none@1@S@Analyzed DNA sequences included delta and beta 5' flanking regions extending from approximately -500 to +50bp (promoter regions), truncated delta and beta 5' flanking regions extending from approximately -250 to +50 bp, and chimeric promoter constructions, which consisted of a distal delta or beta fragment fused to a proximal beta or delta sequence.@(((:tag . "VBN") (:stem . "analyze") (:form . "Analyzed") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "SYM") (:stem . "delta") (:form . "delta") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "SYM") (:stem . 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"beta") (:end . 332) (:start . 328)\n  (:id . 98))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 335) (:start . 333)\n  (:id . 99))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 341)\n  (:start . 336) (:id . 100))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 350)\n  (:start . 342) (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 351) (:start . 350)\n  (:id . 102)))@@@1@61@((:hcues ((:id . :x524.4.1) (:span 333 335))\n  ((:id . :x524.4.2) (:span 291 293)))\n (:hscopes ((:id . :x524.4.1) (:span 328 341))\n  ((:id . :x524.4.2) (:span 285 298)))\n (:identifiers (:sid . :s524.4) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004844@unknown@formal@none@1@S@In CAT reporter constructions no appreciable level of CAT activity was supported by the beta globin promoter, and only low level activity by the delta promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "construction") (:form . "constructions")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "appreciable") (:form . "appreciable") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x524.5.1) (:span 30 32)))\n (:nscopes ((:id . :x524.5.1) (:span 30 108)))\n (:identifiers (:sid . :s524.5) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004845@unknown@formal@none@1@S@Truncation of the beta globin promoter led to a 2-3 fold increase in promoter activity.@(((:tag . "NNP") (:stem . "Truncation") (:form . "Truncation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2-3") (:form . "2-3") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "fold") (:form . "fold") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s524.6) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004846@unknown@formal@none@1@S@In contrast, deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fold") (:form . "fold") (:end . 84) (:start . 80)\n  (:id . 58))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s524.7) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004847@unknown@formal@none@1@S@Coupling of the upstream beta globin sequence from approximately -500 to -250 bp to the truncated delta promoter fragment led to complete extinction of transcription activity, consistent with a negative regulatory effect of the beta globin gene upstream element(s).@(((:tag . "NN") (:stem . "coupling") (:form . "Coupling") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "CD") (:stem . "-500") (:form . "-500") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-250") (:form . "-250") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "VB") (:stem . "complete") (:form . "complete") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "extinction") (:form . "extinction") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 165) (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 186)\n  (:start . 176) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 202)\n  (:start . 194) (:id . 72))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 213)\n  (:start . 203) (:id . 73))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 220)\n  (:start . 214) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 76))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 232) (:start . 228)\n  (:id . 77))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 239)\n  (:start . 233) (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 244) (:start . 240)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 253)\n  (:start . 245) (:id . 80))\n ((:tag . "JJ") (:stem . "element(s)") (:form . "element(s)") (:end . 264)\n  (:start . 254) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s524.8) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004848@unknown@formal@none@1@S@Fusion of the upstream portion of the delta promoter to the truncated beta globin promoter yielded a modest increase in promoter strength relative to the truncated beta gene promoter, indicating the presence of a positive transcriptional element(s) in the upstream delta globin regulatory region.@(((:tag . "NN") (:stem . "fusion") (:form . "Fusion") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "VBD") (:stem . "yield") (:form . "yielded") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "modest") (:form . "modest") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "strength") (:form . "strength") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 173) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 182)\n  (:start . 174) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 207)\n  (:start . 199) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 212) (:start . 211)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 221)\n  (:start . 213) (:id . 77))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 237) (:start . 222) (:id . 78))\n ((:tag . "NN") (:stem . "element(s)") (:form . "element(s)") (:end . 248)\n  (:start . 238) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 251) (:start . 249)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 255) (:start . 252)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 264)\n  (:start . 256) (:id . 82))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 270)\n  (:start . 265) (:id . 83))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 277)\n  (:start . 271) (:id . 84))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 288)\n  (:start . 278) (:id . 85))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 295)\n  (:start . 289) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s524.9) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004850@unknown@formal@none@1@S@DNase I footprinting of the upstream delta-globin region revealed protected sequences corresponding to consensus binding sites for GATA-1 and BP2.@(((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "delta-globin") (:form . "delta-globin") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "JJ") (:stem . "protected") (:form . "protected") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 99)\n  (:start . 86) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 120)\n  (:start . 113) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 126)\n  (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "bp2") (:form . "BP2") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s524.11) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004851@unknown@formal@none@1@S@These results confirm that sequences in the upstream promoter region of the adult beta globin gene contribute to its factor-mediated suppression early in development and then may modulate its expression at a later stage.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "confirm") (:form . "confirm") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "factor-mediated") (:form . "factor-mediated")\n  (:end . 132) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 144)\n  (:start . 133) (:id . 62))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 165)\n  (:start . 154) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 187)\n  (:start . 179) (:id . 69))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 202)\n  (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 205) (:start . 203)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 207) (:start . 206)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 213)\n  (:start . 208) (:id . 74))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 219)\n  (:start . 214) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x524.12.1) (:span 175 178)))\n (:hscopes ((:id . :x524.12.1) (:span 175 219)))\n (:identifiers (:sid . :s524.12) (:did . :|10087993|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004852@unknown@formal@none@1@S@Reduction of tumour necrosis factor alpha expression and signalling in peripheral blood mononuclear cells from patients with thalassaemia or sickle cell anaemia upon treatment with desferrioxamine.@(((:tag . "NN") (:stem . "reduction") (:form . "Reduction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 99)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "thalassaemia") (:form . "thalassaemia") (:end . 137)\n  (:start . 125) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 147)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "anaemia") (:form . "anaemia") (:end . 160)\n  (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 175)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 66))\n ((:tag . "NN") (:stem . "desferrioxamine") (:form . "desferrioxamine")\n  (:end . 196) (:start . 181) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s525.1) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004853@unknown@formal@none@1@S@Recent evidence indicates that the rate of progression of the HIV-1 disease is significantly reduced in thalassaemia major patients upon treatment with high doses of desferrioxamine (DFX).@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thalassaemia") (:form . "thalassaemia") (:end . 116)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 156) (:start . 152)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 162)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "desferrioxamine") (:form . "desferrioxamine")\n  (:end . 181) (:start . 166) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "DFX") (:form . "DFX") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x525.2.1) (:span 16 30)))\n (:hscopes ((:id . :x525.2.1) (:span 16 187)))\n (:identifiers (:sid . :s525.2) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004854@unknown@formal@none@1@S@The authors have previously demonstrated that in vitro exposure of mononuclear cells to DFX decreases the bioavailability of tumour necrosis factor alpha (TNF-alpha) which has a stimulatory effect on HIV-1 replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DFX") (:form . "DFX") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bioavailability") (:form . "bioavailability")\n  (:end . 121) (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 164)\n  (:start . 155) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 189)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 196)\n  (:start . 190) (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 205)\n  (:start . 200) (:id . 73))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 217)\n  (:start . 206) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s525.3) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004855@unknown@formal@none@1@S@In this study, therefore, TNF-alpha bioavailability from mononuclear cells isolated from 10 patients with thalassaemia or sickle cell anaemia given DFX as compared to 10 untreated subjects has been evaluated.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "bioavailability") (:form . "bioavailability")\n  (:end . 51) (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thalassaemia") (:form . "thalassaemia") (:end . 118)\n  (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 128)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "anaemia") (:form . "anaemia") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "NNP") (:stem . "DFX") (:form . "DFX") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 197) (:start . 193)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 207)\n  (:start . 198) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s525.4) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004856@unknown@formal@none@1@S@Evidence is presented showing that DFX treatment reduces TNF-alpha bioavailability (P<0.05) by inhibiting its steady state (P<0.05) and by enhancing its inactivation through binding to soluble TNF-alpha receptor type II (P<0.05).@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DFX") (:form . "DFX") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "bioavailability") (:form . "bioavailability")\n  (:end . 82) (:start . 67) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "P<0.05") (:form . "P<0.05") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "P<0.05") (:form . "P<0.05") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 165)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 202)\n  (:start . 193) (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 211)\n  (:start . 203) (:id . 73))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 216) (:start . 212)\n  (:id . 74))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 219) (:start . 217)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 221) (:start . 220)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "P<0.05") (:form . "P<0.05") (:end . 227)\n  (:start . 221) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s525.5) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004857@unknown@formal@none@1@S@We also show that DFX treatment limits the in vivo activation of NF-kappaB, a transcription factor involved in both TNF-alpha gene transcription and TNF-alpha signalling (P<0.005).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DFX") (:form . "DFX") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "limit") (:form . "limits") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 169)\n  (:start . 159) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "P<0.005") (:form . "P<0.005") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s525.6) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004858@unknown@formal@none@1@S@We conclude that TNF-alpha bioavailability and signalling are impaired in patients upon DFX treatment.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "bioavailability") (:form . "bioavailability")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DFX") (:form . "DFX") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s525.7) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004860@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s525.9) (:did . :|10089140|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004861@unknown@formal@none@1@S@Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adenylate") (:form . "adenylate") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "cyclase") (:form . "cyclase") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "p70(S6)-kinase") (:form . "p70(S6)-kinase")\n  (:end . 51) (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 85) (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gp41") (:form . "gp41") (:end . 112) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "envelope") (:form . "envelope") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 155) (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 161)\n  (:start . 156) (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 166) (:start . 162)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 168) (:start . 167)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s526.1) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004862@unknown@formal@none@1@S@Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "gp41") (:form . "gp41") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "aa565-647") (:form . "aa565-647") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 108) (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "interleukin-10") (:form . "interleukin-10")\n  (:end . 148) (:start . 134) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 167)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 176)\n  (:start . 171) (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 186)\n  (:start . 177) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s526.2) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004863@unknown@formal@none@1@S@The signal cascade transducing this effect is not yet clear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBG") (:stem . "transduce") (:form . "transducing") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x526.3.1) (:span 46 49 54 59)))\n (:hscopes ((:id . :x526.3.1) (:span 0 59)))\n (:identifiers (:sid . :s526.3) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004864@unknown@formal@none@1@S@In this study, we examined whether gp41-induced IL-10 up-regulation is mediated by the previously described synergistic activation of cAMP and NF-kappaB pathways.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "gp41-induced") (:form . "gp41-induced") (:end . 47)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 161)\n  (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x526.4.1) (:span 27 34)))\n (:hscopes ((:id . :x526.4.1) (:span 27 161)))\n (:identifiers (:sid . :s526.4) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004865@unknown@formal@none@1@S@gp41 induced cAMP accumulation in monocytes in a time- and concentration-dependent manner and the adenylate cyclase inhibitor SQ 22536 suppressed gp41-induced IL-10 production in monocytes.@(((:tag . "NN") (:stem . "gp41") (:form . "gp41") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "time-") (:form . "time-") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 82) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adenylate") (:form . "adenylate") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "cyclase") (:form . "cyclase") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NNP") (:stem . "SQ") (:form . "SQ") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "CD") (:stem . "22536") (:form . "22536") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 145)\n  (:start . 135) (:id . 61))\n ((:tag . "JJ") (:stem . "gp41-induced") (:form . "gp41-induced") (:end . 158)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 164)\n  (:start . 159) (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 175)\n  (:start . 165) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 188)\n  (:start . 179) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s526.5) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004866@unknown@formal@none@1@S@In contrast, gp41 failed to stimulate NF-kappaB binding activity in as much as no NF-kappaB bound to the main NF-kappaB-binding site 2 of the IL-10 promoter after addition of gp41.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gp41") (:form . "gp41") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 24) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "much") (:form . "much") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 127) (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 156)\n  (:start . 148) (:id . 68))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gp41") (:form . "gp41") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x526.6.1) (:span 79 81)) ((:id . :x526.6.2) (:span 18 24)))\n (:nscopes ((:id . :x526.6.1) (:span 79 179))\n  ((:id . :x526.6.2) (:span 18 179)))\n (:identifiers (:sid . :s526.6) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004867@unknown@formal@none@1@S@We also examined the involvement of other signal transduction pathways.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s526.7) (:did . :|10089566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004868@unknown@formal@none@1@S@Specific inhibitors of p70(S6)-kinase (rapamycin), and Gi protein (pertussis toxin), prevented induction of IL-10 production by gp41 in monocytes, while inhibitors of the phosphatidylinositol 3-kinase (PI 3-kinase) (wortmannin) and mitogen-activated protein kinase (MAPK) pathway (PD 98059) did not.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "p70(S6)-kinase") (:form . "p70(S6)-kinase")\n  (:end . 37) (:start . 23) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . 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5004870@unknown@formal@none@1@S@Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.@(((:tag . "NNP") (:stem . "Estrone") (:form . "Estrone") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 48) (:start . 33) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta-hydroxysteroid")\n  (:form . "beta-hydroxysteroid") (:end . 83) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 97) (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "hemopoiesis") (:form . "hemopoiesis") (:end . 123)\n  (:start . 112) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s527.1) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004871@unknown@formal@none@1@S@Hormones such as 1 alpha, 25-dihydroxy vitamin D3 (D3), all-trans retinoic acid, and 9-cis retinoic acid stimulate differentiation of myeloid progenitor cells via their interaction with specific hormone receptors.@(((:tag . "NNS") (:stem . "hormone") (:form . "Hormones") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "alpha") (:form . "alpha") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "25-dihydroxy") (:form . "25-dihydroxy") (:end . 38)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 65)\n  (:start . 56) (:id . 55))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "9-cis") (:form . "9-cis") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 99)\n  (:start . 91) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 114)\n  (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 130) (:start . 115) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 152)\n  (:start . 142) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 180)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 202)\n  (:start . 195) (:id . 74))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 212)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s527.2) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004872@unknown@formal@none@1@S@However, the sensitivity of cells to these agents is not merely governed by the expression of their receptors and the availability of ligand to bind them.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "RB") (:stem . "merely") (:form . "merely") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "VBN") (:stem . "govern") (:form . "governed") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 99)\n  (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 130)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s527.3) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004873@unknown@formal@none@1@S@Recent studies from our group suggested that the actions of D3 and retinoids on myelopoiesis also are influenced by endogenous mechanisms involving other steroid hormones.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 161)\n  (:start . 154) (:id . 65))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 170)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x527.4.1) (:span 30 39)))\n (:hscopes ((:id . :x527.4.1) (:span 30 170)))\n (:identifiers (:sid . :s527.4) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004874@unknown@formal@none@1@S@In this study we examined the influence of local estrogen metabolism on the differentiation of HL60 cells and normal primitive myeloid progenitor cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 91) (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s527.5) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004875@unknown@formal@none@1@S@Quantitative thin-layer chromatography (TLC) analyses showed that HL60 and normal cells are able to generate estrone (E1) from estradiol (E2).@(((:tag . "JJ") (:stem . "quantitative") (:form . "Quantitative") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "thin-layer") (:form . "thin-layer") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 38) (:start . 24) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TLC") (:form . "TLC") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 60) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "estrone") (:form . "estrone") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "e1") (:form . "E1") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "estradiol") (:form . "estradiol") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s527.6) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004876@unknown@formal@none@1@S@Neither cell population generated significant amounts of E2 from E1.@(((:tag . "DT") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E1") (:form . "E1") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x527.7.1) (:span 0 7)))\n (:nscopes ((:id . :x527.7.1) (:span 0 67)))\n (:identifiers (:sid . :s527.7) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004877@unknown@formal@none@1@S@Reverse transcriptase polymerase chain reaction and Northern analyses confirmed that normal and leukemic myeloid progenitor cells expressed mRNA for the type I and IV isoforms of 17 beta-hydroxysteroid dehydrogenase.@(((:tag . "JJ") (:stem . "reverse") (:form . "Reverse") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcriptase") (:form . "transcriptase")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 38) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 91)\n  (:start . 85) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 112)\n  (:start . 105) (:id . 55))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 123)\n  (:start . 113) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 144) (:start . 140)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 159) (:start . 158)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 175)\n  (:start . 167) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "beta-hydroxysteroid")\n  (:form . "beta-hydroxysteroid") (:end . 201) (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 215) (:start . 202) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s527.8) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004878@unknown@formal@none@1@S@Conversion of E2 to E1 was upregulated within 24 hours when HL60 cells were treated with either all-trans retinoic acid or D3 at doses that induce their differentiation toward neutrophils or monocytes, respectively.@(((:tag . "NNP") (:stem . "Conversion") (:form . "Conversion") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "E1") (:form . "E1") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 146)\n  (:start . 140) (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 168) (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 175)\n  (:start . 169) (:id . 70))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 187)\n  (:start . 176) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 74))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 214)\n  (:start . 202) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s527.9) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004880@unknown@formal@none@1@S@When HL60 cells or normal myeloid progenitor cells were exposed to exogenous E1 they became more sensitive to the differentiation-inducing effects of D3.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "e1") (:form . "E1") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "become") (:form . "became") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "differentiation-inducing")\n  (:form . "differentiation-inducing") (:end . 138) (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 146)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s527.11) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004881@unknown@formal@none@1@S@Data presented provide further evidence for the local modulation of myelopoiesis by intracrine mechanisms.@(((:tag . "NNP") (:stem . "Datum") (:form . "Data") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 80)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intracrine") (:form . "intracrine") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s527.12) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004882@unknown@formal@none@1@S@In particular, our findings suggest that local metabolism of steroids by normal as well as leukemic myeloid cells influences their responsiveness to D3 and retinoids.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "steroid") (:form . "steroids") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 145) (:start . 131) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 165)\n  (:start . 156) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x527.13.1) (:span 28 35)))\n (:hscopes ((:id . :x527.13.1) (:span 28 165)))\n (:identifiers (:sid . :s527.13) (:did . :|10089907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004883@unknown@formal@none@1@S@Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s528.1) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004884@unknown@formal@none@1@S@Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "etiologic") (:form . "etiologic") (:end . 59)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s528.2) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004885@unknown@formal@none@1@S@The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "translocalization") (:form . "translocalization")\n  (:end . 74) (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 172) (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 193)\n  (:start . 187) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x528.3.1) (:span 119 127)))\n (:hscopes ((:id . :x528.3.1) (:span 110 193)))\n (:identifiers (:sid . :s528.3) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004886@unknown@formal@none@1@S@However, the HTLV-I genes including Tax are not expressed significantly in primary leukemic cells from ATL patients.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "atl") (:form . "ATL") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x528.4.1) (:span 44 47)))\n (:nscopes ((:id . :x528.4.1) (:span 9 115)))\n (:identifiers (:sid . :s528.4) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004887@unknown@formal@none@1@S@In this study, we examined the basis for NF-kappaB activation in freshly isolated leukemic cells from ATL patients.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "atl") (:form . "ATL") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s528.5) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004888@unknown@formal@none@1@S@We found that leukemic cells from ATL patients, like HTLV-I-infected T-cell lines, display constitutive NF-kappaB DNA binding activity and increased degradation of IkappaBalpha (an inhibitor of NF-kappaB).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "atl") (:form . "ATL") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "htlv-i-infected") (:form . "HTLV-I-infected")\n  (:end . 68) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 103)\n  (:start . 91) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 176) (:start . 164) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 190)\n  (:start . 181) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 203)\n  (:start . 194) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s528.6) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004890@unknown@formal@none@1@S@One T-cell line derived from ATL leukemic cells, TL-Om1, displayed constitutive NF-kappaB activity, as well as enhanced degradation of IkappaBalpha, despite the lack of detectable Tax expression.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TL-Om1") (:form . "TL-Om1") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 79)\n  (:start . 67) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 147) (:start . 135) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 156)\n  (:start . 149) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x528.8.1) (:span 161 165)))\n (:nscopes ((:id . :x528.8.1) (:span 161 194)))\n (:identifiers (:sid . :s528.8) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004891@unknown@formal@none@1@S@Interestingly, the NF-kappaB in TL-Om1 consists of p50/p50 and p50/p65 like that in fresh primary leukemic cells.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TL-Om1") (:form . "TL-Om1") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s528.9) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004892@unknown@formal@none@1@S@Our results suggest that activation of NF-kappaB occurs through a Tax-independent mechanism in leukemic cells of ATL patients, possibly due to differential NF-kappaB subunit activation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tax-independent") (:form . "Tax-independent")\n  (:end . 81) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "atl") (:form . "ATL") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 165)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 184)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x528.10.1) (:span 127 135))\n  ((:id . :x528.10.2) (:span 12 19)))\n (:hscopes ((:id . :x528.10.1) (:span 127 184))\n  ((:id . :x528.10.2) (:span 12 184)))\n (:identifiers (:sid . :s528.10) (:did . :|10090947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004893@unknown@formal@none@1@S@Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription.@(((:tag . "JJ") (:stem . "apoptosis-resistant")\n  (:form . "Apoptosis-resistant") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 21) (:start . 20)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 67) (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s529.1) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004894@unknown@formal@none@1@S@Apoptosis induced through the TCR in CD4+ T cells is mostly mediated by the inducible expression of Fas ligand (FasL) as a primary event leading to the commitment to death.@(((:tag . "NNP") (:stem . "Apoptosis") (:form . "Apoptosis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 130)\n  (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 136)\n  (:start . 131) (:id . 67))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 144)\n  (:start . 137) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 162)\n  (:start . 152) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s529.2) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004895@unknown@formal@none@1@S@To gain a better understanding of the transcriptional events that regulate this expression, we took advantage of our previously described mutant Jurkat cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 16) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "take") (:form . "took") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 151)\n  (:start . 145) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s529.3) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004896@unknown@formal@none@1@S@These cells are deficient in FasL expression and apoptosis induced upon TCR triggering, although their cytokine (IL-2 and IFN-gamma) production is normal.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 143)\n  (:start . 133) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s529.4) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004897@unknown@formal@none@1@S@Here we show that both a FasL- and a consensus NF-kappaB- reporter construct are inefficiently induced in these cells compared to wild-type cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fasl-") (:form . "FasL-") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 46)\n  (:start . 37) (:id . 51))\n ((:tag . "NN") (:stem . "nf-kappab-") (:form . "NF-kappaB-") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "inefficiently") (:form . "inefficiently")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s529.5) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004898@unknown@formal@none@1@S@In addition, we demonstrate that the inducible transcriptional activity of the FasL reporter is abolished by specific inhibitors of NF-kappaB activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 141)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s529.6) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004900@unknown@formal@none@1@S@Furthermore, our results suggest that the induction of FasL versus cytokine gene expression is differentially sensitive to NF-kappaB deprivation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 109) (:start . 95) (:id . 57))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x529.8.1) (:span 25 32)))\n (:hscopes ((:id . :x529.8.1) (:span 25 144)))\n (:identifiers (:sid . :s529.8) (:did . :|10092076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004901@unknown@formal@none@1@S@NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "fas/apo-1/cd95-") (:form . "Fas/APO-1/CD95-")\n  (:end . 35) (:start . 20) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcr-") (:form . "TCR-") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s530.1) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004902@unknown@formal@none@1@S@The maintenance of lymphocyte homeostasis by apoptosis is a critical regulatory mechanism in the normal immune system.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 103)\n  (:start . 97) (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s530.2) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004903@unknown@formal@none@1@S@The transcription factor NF-kappaB has been shown to play a role in protecting cells against death mediated by TNF We show here that NF-kappaB also has a role in regulating Fas/APO-1/CD95-mediated death, a major pathway of peripheral T cell death.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "protect") (:form . "protecting") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 142)\n  (:start . 133) (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 172)\n  (:start . 162) (:id . 71))\n ((:tag . "JJ") (:stem . "fas/apo-1/cd95-mediated")\n  (:form . "Fas/APO-1/CD95-mediated") (:end . 196) (:start . 173) (:id . 72))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 205) (:start . 204)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 211)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 219)\n  (:start . 212) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 233)\n  (:start . 223) (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 235) (:start . 234)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 240) (:start . 236)\n  (:id . 81))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 246)\n  (:start . 241) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s530.3) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004904@unknown@formal@none@1@S@Transfection of Jurkat cells with the NF-kappaB subunits p50 and p65 confers resistance against Fas-mediated apoptosis.@(((:tag . "NNP") (:stem . "Transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 118)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s530.4) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004905@unknown@formal@none@1@S@Reciprocally, inhibition of NF-kappaB activation by a soluble peptide inhibitor or a dominant form of the NF-kappaB inhibitor, IkappaB, makes the cells more susceptible to Fas-mediated apoptosis.@(((:tag . "RB") (:stem . "reciprocally") (:form . "Reciprocally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "make") (:form . "makes") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 168)\n  (:start . 157) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 184)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 194)\n  (:start . 185) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s530.5) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004906@unknown@formal@none@1@S@Furthermore, inhibition of NF-kappaB activation by a soluble peptide inhibitor rendered a T cell hybridoma more susceptible to TCR-mediated apoptosis.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "VBD") (:stem . "render") (:form . "rendered") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hybridoma") (:form . "hybridoma") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 123)\n  (:start . 112) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 139)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s530.6) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004907@unknown@formal@none@1@S@Correspondingly, transfection of p50 and p65 provided considerable protection from TCR-mediated apoptosis.@(((:tag . "RB") (:stem . "correspondingly") (:form . "Correspondingly")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "provide") (:form . "provided") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 105)\n  (:start . 96) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s530.7) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004908@unknown@formal@none@1@S@These observations were corroborated by studies on Fas-mediated death in primary T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "corroborate") (:form . "corroborated") (:end . 36)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s530.8) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004910@unknown@formal@none@1@S@In addition, blocking TNF, itself a positive regulator of NF-kappaB, with neutralizing antibodies renders the cells more susceptible to anti-Fas-mediated apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 86)\n  (:start . 74) (:id . 56))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "VBZ") (:stem . "render") (:form . "renders") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 132)\n  (:start . 121) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "anti-fas-mediated") (:form . "anti-Fas-mediated")\n  (:end . 153) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s530.10) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004911@unknown@formal@none@1@S@In summary, our results provide compelling evidence that NF-kappaB protects against Fas-mediated death and is likely to be an important regulator of T cell homeostasis and tolerance.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "compelling") (:form . "compelling") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 96)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 167)\n  (:start . 156) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x530.11.1) (:span 110 116))\n  ((:id . :x530.11.2) (:span 32 51)))\n (:hscopes ((:id . :x530.11.1) (:span 107 181))\n  ((:id . :x530.11.2) (:span 32 181)))\n (:identifiers (:sid . :s530.11) (:did . :|10092091|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004912@unknown@formal@none@1@S@Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 54)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 108) (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 113) (:start . 109)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s531.1) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004913@unknown@formal@none@1@S@Intracellular signals that mediate differentiation of pluripotent hemopoietic progenitors to dendritic cells (DC) are largely undefined.@(((:tag . "JJ") (:stem . "intracellular") (:form . "Intracellular")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 50) (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pluripotent") (:form . "pluripotent") (:end . 65)\n  (:start . 54) (:id . 48))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 77)\n  (:start . 66) (:id . 49))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 89)\n  (:start . 78) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 102)\n  (:start . 93) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . "JJ") (:stem . "undefined") (:form . "undefined") (:end . 135)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s531.2) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004914@unknown@formal@none@1@S@We have previously shown that protein kinase C (PKC) activation (with phorbol ester (PMA) alone) specifically induces differentiation of primary human CD34+ hemopoietic progenitor cells (HPC) to mature DC.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 95) (:start . 90)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 109)\n  (:start . 97) (:id . 63))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 117)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 133) (:start . 118) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 144)\n  (:start . 137) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 168)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 179)\n  (:start . 169) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 201)\n  (:start . 195) (:id . 77))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 204) (:start . 202)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s531.3) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004915@unknown@formal@none@1@S@We now find that cytokine-driven (granulocyte-macrophage CSF and TNF-alpha) CD34+ HPC-->DC differentiation is preferentially blocked by inhibitors of PKC activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cytokine-driven") (:form . "cytokine-driven")\n  (:end . 32) (:start . 17) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 56) (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSF") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HPC–>DC") (:form . "HPC–>DC") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 106) (:start . 91) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 124) (:start . 110) (:id . 57))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 132)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 146)\n  (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 164)\n  (:start . 154) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s531.4) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004916@unknown@formal@none@1@S@To further identify intracellular signals and downstream events important in CD34+ HPC-->DC differentiation we have characterized a human leukemic cell line model of this process.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HPC–>DC") (:form . "HPC–>DC") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 107) (:start . 92) (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 115) (:start . 111)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 129) (:start . 116) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 137)\n  (:start . 132) (:id . 59))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 146)\n  (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 151) (:start . 147)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 156) (:start . 152)\n  (:id . 62))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 162)\n  (:start . 157) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 178)\n  (:start . 171) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s531.5) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004917@unknown@formal@none@1@S@The CD34+ myelomonocytic cell line KG1 differentiates into dendritic-like cells in response to granulocyte-macrophage CSF plus TNF-alpha, or PMA (with or without the calcium ionophore ionomycin, or TNF-alpha), with different stimuli mediating different aspects of the process.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 24) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kg1") (:form . "KG1") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "differentiate") (:form . "differentiates")\n  (:end . 53) (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dendritic-like") (:form . "dendritic-like")\n  (:end . 73) (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 117) (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSF") (:end . 121) (:start . 118)\n  (:id . 56))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 126) (:start . 122)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 136)\n  (:start . 127) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 161)\n  (:start . 154) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 173)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 183)\n  (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 193)\n  (:start . 184) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 207)\n  (:start . 198) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 214) (:start . 210)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 224)\n  (:start . 215) (:id . 76))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 232)\n  (:start . 225) (:id . 77))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 242)\n  (:start . 233) (:id . 78))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 252)\n  (:start . 243) (:id . 79))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 260)\n  (:start . 253) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 263) (:start . 261)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 267) (:start . 264)\n  (:id . 82))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 275)\n  (:start . 268) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x531.6.2) (:span 138 140)))\n (:ncues ((:id . :x531.6.1) (:span 154 161)))\n (:hscopes ((:id . :x531.6.2) (:span 127 144)))\n (:nscopes ((:id . :x531.6.1) (:span 154 207)))\n (:identifiers (:sid . :s531.6) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004918@unknown@formal@none@1@S@Phenotypic DC characteristics of KG1 dendritic-like cells include morphology (loosely adherent cells with long neurite processes), MHC I+/MHC IIbright/CD83+/CD86+/CD14- surface Ag expression, and RelB and DC-CK1 gene expression.@(((:tag . "JJ") (:stem . "phenotypic") (:form . "Phenotypic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kg1") (:form . "KG1") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dendritic-like") (:form . "dendritic-like")\n  (:end . 51) (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "RB") (:stem . "loosely") (:form . "loosely") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "neurite") (:form . "neurite") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 128)\n  (:start . 119) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "I+/MHC") (:form . "I+/MHC") (:end . 141)\n  (:start . 135) (:id . 62))\n ((:tag . "NNP") (:stem . "IIbright/CD83+/CD86+/CD14-")\n  (:form . "IIbright/CD83+/CD86+/CD14-") (:end . 168) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 176)\n  (:start . 169) (:id . 64))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 179) (:start . 177)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 190)\n  (:start . 180) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 200) (:start . 196)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 70))\n ((:tag . "NN") (:stem . "dc-ck1") (:form . "DC-CK1") (:end . 211)\n  (:start . 205) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 216) (:start . 212)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 227)\n  (:start . 217) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s531.7) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004920@unknown@formal@none@1@S@Comparison of KG1 to the PMA-unresponsive subline KG1a reveals differences in expression of TNF receptors 1 and 2; PKC isoforms alpha, beta I, beta II, and mu; and RelB, suggesting that these components/pathways are important for DC differentiation.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kg1") (:form . "KG1") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pma-unresponsive") (:form . "PMA-unresponsive")\n  (:end . 41) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "subline") (:form . "subline") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "NNP") (:stem . "KG1a") (:form . "KG1a") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 158) (:start . 156)\n  (:id . 72))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 159) (:start . 158)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 168) (:start . 164)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 180)\n  (:start . 170) (:id . 77))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 78))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 191)\n  (:start . 186) (:id . 79))\n ((:tag . "NNS") (:stem . "components/pathway")\n  (:form . "components/pathways") (:end . 211) (:start . 192) (:id . 80))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 215) (:start . 212)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 225)\n  (:start . 216) (:id . 82))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 229) (:start . 226)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 232) (:start . 230)\n  (:id . 84))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 248) (:start . 233) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x531.9.1) (:span 170 180)))\n (:hscopes ((:id . :x531.9.1) (:span 170 248)))\n (:identifiers (:sid . :s531.9) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004921@unknown@formal@none@1@S@Together, these findings demonstrate that cytokine or phorbol ester stimulation of KG1 is a model of human CD34+ HPC to DC differentiation and suggest that specific intracellular signaling pathways mediate specific events in DC lineage commitment.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "KG1") (:form . "KG1") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NNP") (:stem . "HPC") (:form . "HPC") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 138) (:start . 123) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 164)\n  (:start . 156) (:id . 68))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 178) (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 188)\n  (:start . 179) (:id . 70))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 197)\n  (:start . 189) (:id . 71))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 205)\n  (:start . 198) (:id . 72))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 214)\n  (:start . 206) (:id . 73))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 221)\n  (:start . 215) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "DC") (:form . "DC") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 235)\n  (:start . 228) (:id . 77))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 246)\n  (:start . 236) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x531.10.1) (:span 143 150))\n  ((:id . :x531.10.2) (:span 51 53)))\n (:hscopes ((:id . :x531.10.1) (:span 143 246))\n  ((:id . :x531.10.2) (:span 42 67)))\n (:identifiers (:sid . :s531.10) (:did . :|10092775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004922@unknown@formal@none@1@S@IL-2-mediated cell cycle progression and inhibition of apoptosis does not require NF-kappa B or activating protein-1 activation in primary human T cells.@(((:tag . "JJ") (:stem . "il-2-mediated") (:form . "IL-2-mediated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x532.1.1) (:span 70 73)))\n (:nscopes ((:id . :x532.1.1) (:span 70 152)))\n (:identifiers (:sid . :s532.1) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004923@unknown@formal@none@1@S@The IL-2 growth hormone is the major growth factor of activated T lymphocytes during a developing immune response.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s532.2) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004924@unknown@formal@none@1@S@IL-2 is required not only for cell cycle progression but also to protect Ag-activated T cells from programmed cell death.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "protect") (:form . "protect") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "ag-activated") (:form . "Ag-activated") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s532.3) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004925@unknown@formal@none@1@S@In several cell types, activation of NF-kappa B and/or activating protein-1 (AP-1) has been demonstrated to be extremely important in blocking apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 104)\n  (:start . 92) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 142)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 152)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s532.4) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004926@unknown@formal@none@1@S@To determine whether either or both of these transcription factors are involved in cell survival or cell cycle progression in response to IL-2, primary human T cells responsive to the growth factor were analyzed for NF-kappa B and AP-1 activation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 72))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 190)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 197)\n  (:start . 191) (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 202) (:start . 198)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 211)\n  (:start . 203) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 215) (:start . 212)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 224)\n  (:start . 216) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 226) (:start . 225)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 235) (:start . 231)\n  (:id . 81))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 246)\n  (:start . 236) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x532.5.1) (:span 28 30)) ((:id . :x532.5.2) (:span 13 20)))\n (:hscopes ((:id . :x532.5.1) (:span 21 35))\n  ((:id . :x532.5.2) (:span 13 142)))\n (:identifiers (:sid . :s532.5) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004927@unknown@formal@none@1@S@The current study clearly demonstrates that IL-2 does not induce I kappa B alpha degradation or NF-kappa B activation in primary human T cells that respond to IL-2 by entering the cell cycle and avoiding apoptosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "enter") (:form . "entering") (:end . 175)\n  (:start . 167) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 184) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 190)\n  (:start . 185) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "avoid") (:form . "avoiding") (:end . 203)\n  (:start . 195) (:id . 76))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 213)\n  (:start . 204) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x532.6.1) (:span 54 57)))\n (:nscopes ((:id . :x532.6.1) (:span 54 213)))\n (:identifiers (:sid . :s532.6) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004928@unknown@formal@none@1@S@Similarly, IL-2 neither activates JNK nor increases AP-1 binding activity to a consensus o-tetradecanoylphorbol 13-acetate (TPA) response element.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "o-tetradecanoylphorbol")\n  (:form . "o-tetradecanoylphorbol") (:end . 111) (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 145)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x532.7.1) (:span 16 23 38 41)))\n (:nscopes ((:id . :x532.7.1) (:span 16 145)))\n (:identifiers (:sid . :s532.7) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004930@unknown@formal@none@1@S@These data show that neither NF-kappa B nor AP-1 activation is required for IL-2-mediated survival or cell cycle progression in activated primary human T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "il-2-mediated") (:form . "IL-2-mediated")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 124)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x532.9.1) (:span 21 28 40 43)))\n (:nscopes ((:id . :x532.9.1) (:span 21 159)))\n (:identifiers (:sid . :s532.9) (:did . :|10092783|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004931@unknown@formal@none@1@S@Impaired fetal thymocyte development after efficient adenovirus-mediated inhibition of NF-kappa B activation.@(((:tag . "JJ") (:stem . "impaired") (:form . "Impaired") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "adenovirus-mediated")\n  (:form . "adenovirus-mediated") (:end . 72) (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 83)\n  (:start . 73) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s533.1) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004932@unknown@formal@none@1@S@We introduce a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "introduce") (:form . "introduce") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "adenovirus-mediated")\n  (:form . "adenovirus-mediated") (:end . 68) (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 92) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 99)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FTOC") (:form . "FTOC") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s533.2) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004933@unknown@formal@none@1@S@This system allowed us to efficiently express in developing thymocytes a mutant form of the NF-kappa B inhibitor I kappa B alpha (mut-I kappa B) and to study the maturation defects occurring when NF-kappa B activation is inhibited during fetal development.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mut-i") (:form . "mut-I") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 157)\n  (:start . 152) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 72))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 172)\n  (:start . 162) (:id . 73))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 180)\n  (:start . 173) (:id . 74))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 190)\n  (:start . 181) (:id . 75))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 195) (:start . 191)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 204)\n  (:start . 196) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 78))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 217)\n  (:start . 207) (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 220) (:start . 218)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 230)\n  (:start . 221) (:id . 81))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 237)\n  (:start . 231) (:id . 82))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 243)\n  (:start . 238) (:id . 83))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 255)\n  (:start . 244) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s533.3) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004934@unknown@formal@none@1@S@Fetal thymocytes infected with adenovirus containing mut-I kappa B were found to develop normally until the CD44-CD25+, CD4-CD8- double-negative stage, while production of more mature double-positive and single-positive populations was strongly decreased.@(((:tag . "JJ") (:stem . "fetal") (:form . "Fetal") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "mut-I") (:form . "mut-I") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VB") (:stem . "develop") (:form . "develop") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cd44-cd25+") (:form . "CD44-CD25+") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cd4-cd8-") (:form . "CD4-CD8-") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "double-negative") (:form . "double-negative")\n  (:end . 144) (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 168)\n  (:start . 158) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 183)\n  (:start . 177) (:id . 68))\n ((:tag . "JJ") (:stem . "double-positive") (:form . "double-positive")\n  (:end . 199) (:start . 184) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "single-positive") (:form . "single-positive")\n  (:end . 219) (:start . 204) (:id . 71))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 231)\n  (:start . 220) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 235) (:start . 232)\n  (:id . 73))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 244)\n  (:start . 236) (:id . 74))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 254)\n  (:start . 245) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s533.4) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004935@unknown@formal@none@1@S@Proliferation, as measured by the percentage of cells in cycle appeared normal, as did rearrangement and expression of the TCR beta-chain.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 100) (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s533.5) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004936@unknown@formal@none@1@S@However, apoptosis was much higher in FTOC infected with adenovirus containing mut-I kappa B than in FTOC infected with a control virus.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 34) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FTOC") (:form . "FTOC") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "mut-i") (:form . "mut-I") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "FTOC") (:form . "FTOC") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s533.6) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004937@unknown@formal@none@1@S@Taken together, these results suggest that NF-kappa B plays a crucial role in ensuring the differentiation and survival of thymocytes in the early stages of their development.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "ensure") (:form . "ensuring") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 106) (:start . 91) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 174)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x533.7.1) (:span 30 37)))\n (:hscopes ((:id . :x533.7.1) (:span 30 174)))\n (:identifiers (:sid . :s533.7) (:did . :|10092801|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004938@unknown@formal@none@1@S@Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "4E-BP1") (:form . "4E-BP1") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "4E-BP2") (:form . "4E-BP2") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "repressor") (:form . "repressors") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 129) (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s534.1) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004940@unknown@formal@none@1@S@Because the translation rate is an important determinant of cell proliferation, we have investigated translation initiation during human myeloid cell differentiation using the HL-60 promyelocytic leukemia cell line and the U-937 monoblastic cell line.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 78) (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 100)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 165) (:start . 150) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 171) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 181)\n  (:start . 176) (:id . 66))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 195) (:start . 182) (:id . 67))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 204)\n  (:start . 196) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 209) (:start . 205)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 214) (:start . 210)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 218) (:start . 215)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 72))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 228)\n  (:start . 223) (:id . 73))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 240)\n  (:start . 229) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 245) (:start . 241)\n  (:id . 75))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 250) (:start . 246)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s534.3) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004941@unknown@formal@none@1@S@A decrease in the translation rate is observed when the cells are induced to differentiate along the monocytic/macrophage pathway or along the granulocytic pathway.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "monocytic/macrophage")\n  (:form . "monocytic/macrophage") (:end . 121) (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 163)\n  (:start . 156) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s534.4) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004942@unknown@formal@none@1@S@The inhibition in protein synthesis correlates with specific regulation of two repressors of translation initiation, 4E-BP1 and 4E-BP2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "repressor") (:form . "repressors") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "4E-BP1") (:form . "4E-BP1") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "4E-BP2") (:form . "4E-BP2") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s534.5) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004943@unknown@formal@none@1@S@Induction of HL-60 and U-937 cell differentiation into monocytes/macrophages by IFN-gamma or PMA results in a dephosphorylation and consequent activation of 4E-BP1.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "U-937") (:form . "U-937") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 49) (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 76) (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dephosphorylation") (:form . "dephosphorylation")\n  (:end . 127) (:start . 110) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "consequent") (:form . "consequent") (:end . 142)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "4E-BP1") (:form . "4E-BP1") (:end . 163)\n  (:start . 157) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s534.6) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004944@unknown@formal@none@1@S@Dephosphorylation of 4E-BP1 was also observed when U-937 cells were induced to differentiate into monocytes/macrophages following treatment with retinoic acid or DMSO.@(((:tag . "NN") (:stem . "dephosphorylation") (:form . "Dephosphorylation")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "4E-BP1") (:form . "4E-BP1") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 119) (:start . 98) (:id . 56))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 129)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 153)\n  (:start . 145) (:id . 60))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 158) (:start . 154)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 161) (:start . 159)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DMSO") (:form . "DMSO") (:end . 166) (:start . 162)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s534.7) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004945@unknown@formal@none@1@S@In contrast, treatment of HL-60 cells with retinoic acid or DMSO, which results in a granulocytic differentiation of these cells, decreases 4E-BP1 amount without affecting its phosphorylation and strongly increases 4E-BP2 amount.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DMSO") (:form . "DMSO") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 97)\n  (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 113) (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 139)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "4e-bp1") (:form . "4E-BP1") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 153)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 171)\n  (:start . 162) (:id . 69))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 191) (:start . 176) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 204)\n  (:start . 196) (:id . 73))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 214)\n  (:start . 205) (:id . 74))\n ((:tag . "NN") (:stem . "4e-bp2") (:form . "4E-BP2") (:end . 221)\n  (:start . 215) (:id . 75))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 228)\n  (:start . 222) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x534.8.1) (:span 154 161)))\n (:nscopes ((:id . :x534.8.1) (:span 154 191)))\n (:identifiers (:sid . :s534.8) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004946@unknown@formal@none@1@S@Taken together, these data provide evidence for differential regulation of the translational machinery during human myeloid differentiation, specific to the monocytic/macrophage pathway or to the granulocytic pathway.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 139) (:start . 124) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 149)\n  (:start . 141) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "monocytic/macrophage")\n  (:form . "monocytic/macrophage") (:end . 177) (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 185)\n  (:start . 178) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 188) (:start . 186)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 208)\n  (:start . 196) (:id . 69))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 216)\n  (:start . 209) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s534.9) (:did . :|10092805|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004947@unknown@formal@none@1@S@Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "immunogenic") (:form . "immunogenic") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "melanoma") (:form . "melanomas") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 75)\n  (:start . 70) (:id . 51))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lymphocyte-mediated")\n  (:form . "lymphocyte-mediated") (:end . 107) (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 113)\n  (:start . 108) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s535.1) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004948@unknown@formal@none@1@S@Here, we report the functional expression of CD40 on human malignant melanomas (MMs).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "melanoma") (:form . "melanomas") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MM") (:form . "MMs") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s535.2) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004950@unknown@formal@none@1@S@CD40 expression was confirmed in 7 human MM cell lines established from immunogenic primary tumors or metastases, whereas 11 cell lines established from advanced stages were CD40 negative.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immunogenic") (:form . "immunogenic") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "metastasis") (:form . "metastases") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 147)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "advance") (:form . "advanced") (:end . 161)\n  (:start . 153) (:id . 66))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s535.4) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004951@unknown@formal@none@1@S@CD40 expression could be enhanced in CD40-positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd40-positive") (:form . "CD40-positive")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "mm") (:form . "MM") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 115)\n  (:start . 103) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 138)\n  (:start . 127) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL)-1beta") (:form . "IL)-1beta") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x535.5.1) (:span 120 123)))\n (:nscopes ((:id . :x535.5.1) (:span 120 168)))\n (:identifiers (:sid . :s535.5) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004952@unknown@formal@none@1@S@CD40 ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a, and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cd40l-transfected") (:form . 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5004953@unknown@formal@none@1@S@Furthermore, CD40 ligation of a HLA-A2+, MelanA/MART1+ MM cell line enhanced its susceptibility to specific lysis by a HLA-A2-restricted, MelanA/MART-1-specific CTL clone.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hla-a2+") (:form . "HLA-A2+") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "melana/mart1+") (:form . "MelanA/MART1+")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 95) (:start . 81) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "hla-a2-restricted") (:form . "HLA-A2-restricted")\n  (:end . 136) (:start . 119) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "melana/mart-1-specific")\n  (:form . "MelanA/MART-1-specific") (:end . 160) (:start . 138) (:id . 64))\n ((:tag . "NNP") (:stem . "CTL") (:form . "CTL") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s535.7) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004954@unknown@formal@none@1@S@Finally, CD40 ligation induced growth inhibition and apoptosis in MM.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MM") (:form . "MM") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s535.8) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004955@unknown@formal@none@1@S@These results indicate that CD40-CD40L interactions may play an important role in augmenting antitumor immunity and inducing apoptosis in some CD40-positive immunogenic human MMs.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd40-cd40l") (:form . "CD40-CD40L") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "augment") (:form . "augmenting") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "antitumor") (:form . "antitumor") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cd40-positive") (:form . "CD40-positive")\n  (:end . 156) (:start . 143) (:id . 62))\n ((:tag . "JJ") (:stem . "immunogenic") (:form . "immunogenic") (:end . 168)\n  (:start . 157) (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 174)\n  (:start . 169) (:id . 64))\n ((:tag . "NNS") (:stem . "mm") (:form . "MMs") (:end . 178) (:start . 175)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x535.9.1) (:span 52 55)) ((:id . :x535.9.2) (:span 14 27)))\n (:hscopes ((:id . :x535.9.1) (:span 52 178))\n  ((:id . :x535.9.2) (:span 14 178)))\n (:identifiers (:sid . :s535.9) (:did . :|10096561|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004956@unknown@formal@none@1@S@Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.@(((:tag . "JJ") (:stem . "essential") (:form . "Essential") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intrapulmonary") (:form . "intrapulmonary")\n  (:end . 56) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s536.1) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004957@unknown@formal@none@1@S@Acute inflammatory injury in rat lung induced by deposition of immunoglobulin G immune complexes requires expression of cytokines and chemokines as well as activation of the transcription factor nuclear factor (NF)-kappaB.@(((:tag . "JJ") (:stem . "acute") (:form . "Acute") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "deposition") (:form . "deposition") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 166)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 187) (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 194)\n  (:start . 188) (:id . 69))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 202)\n  (:start . 195) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 209)\n  (:start . 203) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 221)\n  (:start . 211) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s536.2) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004958@unknown@formal@none@1@S@There is little direct evidence regarding the role of alveolar macrophages in these activation events.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBG") (:stem . "regard") (:form . "regarding") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s536.3) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004960@unknown@formal@none@1@S@These procedures, which greatly reduced the number of retrievable alveolar macrophages, suppressed activation of lung NF-kappaB in the inflammatory model.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "procedure") (:form . "procedures") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "retrievable") (:form . "retrievable") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 147)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s536.5) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004961@unknown@formal@none@1@S@In addition, bronchoalveolar lavage levels of tumor necrosis factor-alpha (TNF-alpha) and the CXC chemokine, macrophage inflammatory protein-2, were substantially reduced.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "bronchoalveolar") (:form . "bronchoalveolar")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "lavage") (:form . "lavage") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CXC") (:form . "CXC") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 132)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "protein-2") (:form . "protein-2") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 162) (:start . 149) (:id . 65))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 170)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s536.6) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004962@unknown@formal@none@1@S@In parallel, upregulation of the lung vascular adhesion molecule, intercellular adhesion molecule-1, was greatly reduced by intrapulmonary instillation of phosphonate-containing liposomes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 79) (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intrapulmonary") (:form . "intrapulmonary")\n  (:end . 138) (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "instillation") (:form . "instillation") (:end . 151)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "phosphonate-containing")\n  (:form . "phosphonate-containing") (:end . 177) (:start . 155) (:id . 64))\n ((:tag . "NNS") (:stem . "liposome") (:form . "liposomes") (:end . 187)\n  (:start . 178) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s536.7) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004963@unknown@formal@none@1@S@Neutrophil accumulation and development of lung injury were also substantially diminished.@(((:tag . "NNP") (:stem . "Neutrophil") (:form . "Neutrophil") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 23)\n  (:start . 11) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s536.8) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004964@unknown@formal@none@1@S@Lung instillation of TNF-alpha in alveolar macrophage-depleted rats restored the NF-kappaB activation response in whole lung.@(((:tag . "NNP") (:stem . "Lung") (:form . "Lung") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instillation") (:form . "instillation") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "macrophage-depleted")\n  (:form . "macrophage-depleted") (:end . 62) (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 110)\n  (:start . 102) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 119)\n  (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 124) (:start . 120)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s536.9) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004965@unknown@formal@none@1@S@These data suggest that, in this inflammatory model, initial activation of NF-kappaB occurs in alveolar macrophages and the ensuing production of TNF-alpha may propagate NF-kappaB activation to other cell types in the lung.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 45)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "ensue") (:form . "ensuing") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "VB") (:stem . "propagate") (:form . "propagate") (:end . 169)\n  (:start . 160) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 179)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 190)\n  (:start . 180) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 199)\n  (:start . 194) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 204) (:start . 200)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 75))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x536.10.1) (:span 156 159))\n  ((:id . :x536.10.2) (:span 11 18)))\n (:hscopes ((:id . :x536.10.1) (:span 156 222))\n  ((:id . :x536.10.2) (:span 11 222)))\n (:identifiers (:sid . :s536.10) (:did . :|10101001|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004966@unknown@formal@none@1@S@Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cyclooxygenase-2") (:form . "cyclooxygenase-2")\n  (:end . 30) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "4-trifluoromethyl") (:form . "4-trifluoromethyl")\n  (:end . 62) (:start . 45) (:id . 47))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 74)\n  (:start . 63) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 49))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 88)\n  (:start . 78) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 51))\n ((:tag . "NN") (:stem . "triflusal") (:form . "triflusal") (:end . 99)\n  (:start . 90) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "deacetylate") (:form . "deacetylated") (:end . 121)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 132)\n  (:start . 122) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "2-hydroxy-4-trifluoromethylbenzoic")\n  (:form . "2-hydroxy-4-trifluoromethylbenzoic") (:end . 168) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 173) (:start . 169)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s537.1) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004967@unknown@formal@none@1@S@The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclooxygenase-2") (:form . "cyclooxygenase-2")\n  (:end . 79) (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "emphasize") (:form . "emphasized") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s537.2) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004968@unknown@formal@none@1@S@When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "4-trifluoromethyl") (:form . "4-trifluoromethyl")\n  (:end . 26) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "derivative") (:form . 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5004970@unknown@formal@none@1@S@To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "discrepancy") (:form . "discrepancy") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "realize") (:form . "realized") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HTB") (:form . "HTB") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "triflusal") (:form . "triflusal") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 141) (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cox-2") (:form . "COX-2") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 194)\n  (:start . 184) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 200)\n  (:start . 195) (:id . 71))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 212)\n  (:start . 201) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x537.5.1) (:span 75 82 91 94)))\n (:nscopes ((:id . :x537.5.1) (:span 75 105)))\n (:identifiers (:sid . :s537.5) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004971@unknown@formal@none@1@S@This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "air") (:form . "air") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "triflusal") (:form . "triflusal") (:end . 108)\n  (:start . 99) (:id . 61))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 134)\n  (:start . 124) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "id50") (:form . "ID50") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "CD") (:stem . "18.9") (:form . "18.9") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "CD") (:stem . "11.4") (:form . "11.4") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mg/kg") (:form . "mg/kg") (:end . 162)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "p.o.") (:form . "p.o.") (:end . 167) (:start . 163)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 73))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 181)\n  (:start . 169) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 75))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 186) (:start . 183)\n  (:id . 76))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 191) (:start . 187)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "triflusal-treated") (:form . "triflusal-treated")\n  (:end . 209) (:start . 192) (:id . 78))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 217)\n  (:start . 210) (:id . 79))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 224)\n  (:start . 218) (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 226) (:start . 225)\n  (:id . 81))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 235)\n  (:start . 227) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 238) (:start . 236)\n  (:id . 83))\n ((:tag . "NN") (:stem . "cox-2") (:form . "COX-2") (:end . 244)\n  (:start . 239) (:id . 84))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 255)\n  (:start . 245) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s537.6) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004972@unknown@formal@none@1@S@This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "behavior") (:form . "behavior") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 68)\n  (:start . 61) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HTB") (:form . "HTB") (:end . 75) (:start . 72)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 59))\n ((:tag . "NN") (:stem . "triflusal") (:form . "triflusal") (:end . 89)\n  (:start . 80) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 98) (:start . 93)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 134) (:start . 121) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 141)\n  (:start . 135) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 149)\n  (:start . 142) (:id . 69))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 163) (:start . 150) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 175)\n  (:start . 169) (:id . 73))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 182)\n  (:start . 176) (:id . 74))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 195)\n  (:start . 188) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 77))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 206)\n  (:start . 200) (:id . 78))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 217)\n  (:start . 207) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x537.7.1) (:span 24 27)))\n (:hscopes ((:id . :x537.7.1) (:span 24 217)))\n (:identifiers (:sid . :s537.7) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004973@unknown@formal@none@1@S@Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cox-2") (:form . "COX-2") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 80) (:start . 66) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "triflusal") (:form . "triflusal") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "htb") (:form . "HTB") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "resumption") (:form . "resumption") (:end . 190)\n  (:start . 180) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 74))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 198) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 208)\n  (:start . 199) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s537.8) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004974@unknown@formal@none@1@S@Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.@(((:tag . "NNP") (:stem . "Triflusal") (:form . "Triflusal") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HTB") (:form . "HTB") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cox-2") (:form . "COX-2") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "broad") (:form . "broader") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "pathological") (:form . "pathological") (:end . 146)\n  (:start . 134) (:id . 67))\n ((:tag . "NNS") (:stem . "situation") (:form . "situations") (:end . 157)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 178)\n  (:start . 173) (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 186)\n  (:start . 179) (:id . 73))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 200) (:start . 187) (:id . 74))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 208)\n  (:start . 201) (:id . 75))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 225)\n  (:start . 213) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x537.9.1) (:span 18 21)))\n (:hscopes ((:id . :x537.9.1) (:span 18 225)))\n (:identifiers (:sid . :s537.9) (:did . :|10101034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004975@unknown@formal@none@1@S@Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s538.1) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004976@unknown@formal@none@1@S@According to current models the inhibitory capacity of I(kappa)B(alpha) would be mediated through the retention of Rel/NF-kappaB proteins in the cytosol.@(((:tag . "VBG") (:stem . "accord") (:form . "According") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 71) (:start . 55) (:id . 50))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "retention") (:form . "retention") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Rel/NF-kappaB") (:form . "Rel/NF-kappaB")\n  (:end . 128) (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 152)\n  (:start . 145) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x538.2.1) (:span 72 77)))\n (:hscopes ((:id . :x538.2.1) (:span 28 152)))\n (:identifiers (:sid . :s538.2) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004977@unknown@formal@none@1@S@However, I(kappa)B(alpha) has also been detected in the nucleus of cell lines and when overexpressed by transient transfection.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 25) (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 100) (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 126)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s538.3) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004978@unknown@formal@none@1@S@To gain better insight into the potential role of nuclear I(kappa)B(alpha) in a physiological context we have analysed its presence in the nucleus of human peripheral blood T lymphocytes (PBL).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 74) (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 166)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 186)\n  (:start . 175) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s538.4) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004980@unknown@formal@none@1@S@Low levels of nuclear I(kappa)B(alpha) were detected in resting cells whereas a superinduction was obtained after PMA activation.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 38) (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "superinduction") (:form . "superinduction")\n  (:end . 94) (:start . 80) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s538.6) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004981@unknown@formal@none@1@S@The nuclear pool of I(kappa)B(alpha) showed a higher stability than cytosolic I(kappa)B(alpha) and was partially independent of the resynthesis of the protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "pool") (:form . "pool") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 43) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 52) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 94) (:start . 78) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 124)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "resynthesis") (:form . "resynthesis") (:end . 143)\n  (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s538.7) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004982@unknown@formal@none@1@S@Unexpectedly, the presence of nuclear I(kappa)B(alpha) did not inhibit NF-kappaB binding to DNA and this phenomenon was not due to the presence of IkappaBbeta at the nuclear level.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 54) (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x538.8.1) (:span 120 123))\n  ((:id . :x538.8.2) (:span 59 62)))\n (:nscopes ((:id . :x538.8.1) (:span 120 179))\n  ((:id . :x538.8.2) (:span 59 95)))\n (:identifiers (:sid . :s538.8) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004983@unknown@formal@none@1@S@Immunoprecipitation experiments failed to demonstrate an association between nuclear I(kappa)B(alpha) and NF-kappaB proteins.@(((:tag . "NNP") (:stem . "Immunoprecipitation")\n  (:form . "Immunoprecipitation") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 31)\n  (:start . 20) (:id . 43))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 38) (:start . 32)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 45))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 53)\n  (:start . 42) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 47))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 68)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 76)\n  (:start . 69) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 84)\n  (:start . 77) (:id . 50))\n ((:tag . "NNS") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 101) (:start . 85) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 115)\n  (:start . 106) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 124)\n  (:start . 116) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x538.9.1) (:span 32 38)))\n (:nscopes ((:id . :x538.9.1) (:span 32 124)))\n (:identifiers (:sid . :s538.9) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004984@unknown@formal@none@1@S@Our results demonstrate that in resting and PMA-activated human PBL, I(kappa)B(alpha) is present in the nucleus in an apparently inactive form unable to disrupt NF-kappaB binding from DNA.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pma-activated") (:form . "PMA-activated")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "I(kappa)B(alpha)") (:form . "I(kappa)B(alpha)")\n  (:end . 85) (:start . 69) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 170)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x538.10.1) (:span 118 128)))\n (:ncues ((:id . :x538.10.2) (:span 143 149)))\n (:hscopes ((:id . :x538.10.1) (:span 118 137)))\n (:nscopes ((:id . :x538.10.2) (:span 115 187)))\n (:identifiers (:sid . :s538.10) (:did . :|10102628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004985@unknown@formal@none@1@S@PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta-(1,3)-glucan receptor.@(((:tag . "NNP") (:stem . "PGG-glucan") (:form . "PGG-glucan") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "beta-(1,3)-glucan") (:form . "beta-(1,3)-glucan")\n  (:end . 39) (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "microbicidal") (:form . "microbicidal") (:end . 92)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "glycosphingolipid") (:form . "glycosphingolipid")\n  (:end . 189) (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "beta-(1,3)-glucan") (:form . "beta-(1,3)-glucan")\n  (:end . 207) (:start . 190) (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 216)\n  (:start . 208) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s539.1) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004986@unknown@formal@none@1@S@PGG-Glucan, a soluble beta-(1,6)-branched beta-(1,3)-linked glucose homopolymer derived from the cell wall of the yeast Saccharomyces cerevisiae, is an immunomodulator which enhances leukocyte anti-infective activity and enhances myeloid and megakaryocyte progenitor proliferation.@(((:tag . "NNP") (:stem . "PGG-Glucan") (:form . "PGG-Glucan") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "beta-(1,6)-branched")\n  (:form . "beta-(1,6)-branched") (:end . 41) (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "beta-(1,3)-linked") (:form . "beta-(1,3)-linked")\n  (:end . 59) (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 67)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "homopolymer") (:form . "homopolymer") (:end . 79)\n  (:start . 68) (:id . 49))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 87)\n  (:start . 80) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 53))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 106) (:start . 102)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "FW") (:stem . "saccharomyces") (:form . "Saccharomyces")\n  (:end . 133) (:start . 120) (:id . 58))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 144)\n  (:start . 134) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "NN") (:stem . "immunomodulator") (:form . "immunomodulator")\n  (:end . 167) (:start . 152) (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 173)\n  (:start . 168) (:id . 64))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 192)\n  (:start . 183) (:id . 66))\n ((:tag . "JJ") (:stem . "anti-infective") (:form . "anti-infective")\n  (:end . 207) (:start . 193) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 216)\n  (:start . 208) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 229)\n  (:start . 221) (:id . 70))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 237)\n  (:start . 230) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 241) (:start . 238)\n  (:id . 72))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 255) (:start . 242) (:id . 73))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 266)\n  (:start . 256) (:id . 74))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 280) (:start . 267) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s539.2) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004987@unknown@formal@none@1@S@Incubation of human whole blood with PGG-Glucan significantly enhanced the oxidative burst response of subsequently isolated blood leukocytes to both soluble and particulate activators in a dose-dependent manner, and increased leukocyte microbicidal activity.@(((:tag . "NN") (:stem . "incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PGG-Glucan") (:form . "PGG-Glucan") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 61) (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 115)\n  (:start . 103) (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 141)\n  (:start . 131) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 149) (:start . 145)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 157)\n  (:start . 150) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "particulate") (:form . "particulate") (:end . 173)\n  (:start . 162) (:id . 64))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 184)\n  (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 189) (:start . 188)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 204) (:start . 190) (:id . 68))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 211)\n  (:start . 205) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 226)\n  (:start . 217) (:id . 72))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 236)\n  (:start . 227) (:id . 73))\n ((:tag . "JJ") (:stem . "microbicidal") (:form . "microbicidal") (:end . 249)\n  (:start . 237) (:id . 74))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 258)\n  (:start . 250) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s539.3) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004988@unknown@formal@none@1@S@No evidence for inflammatory cytokine production was obtained under these conditions.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x539.4.1) (:span 0 2)))\n (:nscopes ((:id . :x539.4.1) (:span 0 84)))\n (:identifiers (:sid . :s539.4) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004990@unknown@formal@none@1@S@The binding of 3H-PGG-Glucan to human leukocyte membranes was specific, concentration-dependent, saturable, and high affinity (Kd approximately 6 nM).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "3H-PGG-Glucan") (:form . "3H-PGG-Glucan")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 95) (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "saturable") (:form . "saturable") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 143) (:start . 130) (:id . 62))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s539.6) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004991@unknown@formal@none@1@S@A monoclonal antibody specific to the glycosphingolipid lactosylceramide was able to inhibit activation of the NF-kappaB-like factor by PGG-Glucan, and ligand binding data, including polysaccharide specificity, suggested that the PGG-Glucan binding moiety was lactosylceramide.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glycosphingolipid") (:form . "glycosphingolipid")\n  (:end . 55) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "lactosylceramide") (:form . "lactosylceramide")\n  (:end . 72) (:start . 56) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nf-kappab-like") (:form . "NF-kappaB-like")\n  (:end . 125) (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 132)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PGG-Glucan") (:form . "PGG-Glucan") (:end . 146)\n  (:start . 136) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 171)\n  (:start . 167) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 182)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "polysaccharide") (:form . "polysaccharide")\n  (:end . 197) (:start . 183) (:id . 68))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 209)\n  (:start . 198) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 220)\n  (:start . 211) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 225) (:start . 221)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 73))\n ((:tag . "NN") (:stem . "pgg-glucan") (:form . "PGG-Glucan") (:end . 240)\n  (:start . 230) (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 248)\n  (:start . 241) (:id . 75))\n ((:tag . "NN") (:stem . "moiety") (:form . "moiety") (:end . 255)\n  (:start . 249) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 259) (:start . 256)\n  (:id . 77))\n ((:tag . "NN") (:stem . "lactosylceramide") (:form . "lactosylceramide")\n  (:end . 276) (:start . 260) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x539.7.1) (:span 211 220)))\n (:hscopes ((:id . :x539.7.1) (:span 211 276)))\n (:identifiers (:sid . :s539.7) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004992@unknown@formal@none@1@S@These results indicate that PGG-Glucan enhances neutrophil anti-microbial functions and that interaction between this beta-glucan and human neutrophils is mediated by the glycosphingolipid lactosylceramide present at the cell surface.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PGG-Glucan") (:form . "PGG-Glucan") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "JJ") (:stem . "anti-microbial") (:form . "anti-microbial")\n  (:end . 73) (:start . 59) (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 83)\n  (:start . 74) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 104)\n  (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 112)\n  (:start . 105) (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta-glucan") (:form . "beta-glucan") (:end . 129)\n  (:start . 118) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 58))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 151)\n  (:start . 140) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 154) (:start . 152)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 163)\n  (:start . 155) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 63))\n ((:tag . "NN") (:stem . "glycosphingolipid") (:form . "glycosphingolipid")\n  (:end . 188) (:start . 171) (:id . 64))\n ((:tag . "NN") (:stem . "lactosylceramide") (:form . "lactosylceramide")\n  (:end . 205) (:start . 189) (:id . 65))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 213)\n  (:start . 206) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 216) (:start . 214)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 225) (:start . 221)\n  (:id . 69))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 233)\n  (:start . 226) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x539.8.1) (:span 14 27)))\n (:hscopes ((:id . :x539.8.1) (:span 14 233)))\n (:identifiers (:sid . :s539.8) (:did . :|10102791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004993@unknown@formal@none@1@S@[Corticoids and allergy]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "corticoid") (:form . "Corticoids") (:end . 11)\n  (:start . 1) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "allergy") (:form . "allergy") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 24) (:start . 23)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s540.1) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5004994@unknown@formal@none@1@S@Inflammation is constantly observed in allergic reactions.@(((:tag . "NNP") (:stem . "Inflammation") (:form . "Inflammation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "RB") (:stem . "constantly") (:form . "constantly") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s540.2) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004995@unknown@formal@none@1@S@Corticosteroids are most effective in preventing the late phase of allergic reaction.@(((:tag . "NNS") (:stem . "corticosteroid") (:form . "Corticosteroids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s540.3) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004996@unknown@formal@none@1@S@The action of glucocorticosteroids is mediated through glucocorticoid receptors present in the cellular cytoplasm.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroids") (:end . 34) (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 69) (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s540.4) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004997@unknown@formal@none@1@S@When activated, glucocorticoid receptors form a dimer and bind to DNA after migration into the nucleus.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s540.5) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5004998@unknown@formal@none@1@S@Interaction to DNA induces changes in the transcription rate, leading to either gene induction or gene repression.@(((:tag . "NNP") (:stem . "Interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x540.6.1) (:span 73 79 95 97)))\n (:hscopes ((:id . :x540.6.1) (:span 73 113)))\n (:identifiers (:sid . :s540.6) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005000@unknown@formal@none@1@S@Through these actions glucocorticosteroids are susceptible to modify functions of cells involved in the allergic inflammatory response.@(((:tag . "IN") (:stem . "through") (:form . "Through") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroids") (:end . 42) (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 58)\n  (:start . 47) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "VB") (:stem . "modify") (:form . "modify") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 125)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 134)\n  (:start . 126) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s540.8) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005001@unknown@formal@none@1@S@They are in particular able to inhibit most of the pro-inflammatory functions of the eosinophils.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 67) (:start . 51) (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s540.9) (:did . :|10191934|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005002@unknown@formal@none@1@S@Activation of NF-kappaB in Mycobacterium tuberculosis- induced interleukin-2 receptor expression in mononuclear phagocytes.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "tuberculosis-") (:form . "tuberculosis-")\n  (:end . 54) (:start . 41) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 76) (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 85)\n  (:start . 77) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 111)\n  (:start . 100) (:id . 53))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 122)\n  (:start . 112) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s541.1) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005003@unknown@formal@none@1@S@Soluble interleukin-2 receptor-alpha (IL-2Ralpha) has been reported to be increased in the sera of patients with advanced tuberculosis, and levels decline after therapy in accordance with improvement of radiologic findings.@(((:tag . "JJ") (:stem . "soluble") (:form . "Soluble") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "receptor-alpha") (:form . "receptor-alpha")\n  (:end . 36) (:start . 22) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "serum") (:form . "sera") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "advance") (:form . "advanced") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 134)\n  (:start . 122) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . "VBP") (:stem . "decline") (:form . "decline") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 168)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "accordance") (:form . "accordance") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "improvement") (:form . "improvement") (:end . 199)\n  (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "radiologic") (:form . "radiologic") (:end . 213)\n  (:start . 203) (:id . 73))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 222)\n  (:start . 214) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s541.2) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005004@unknown@formal@none@1@S@We investigated expression of the IL-2Ralpha in bronchoalveolar lavage (BAL) cells in active pulmonary tuberculosis, and evaluated the mechanism Mycobacterium tuberculosis induces in the IL-2Ralpha using the THP-1 mononuclear phagocyte cell line.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "bronchoalveolar") (:form . "bronchoalveolar")\n  (:end . 63) (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "lavage") (:form . "lavage") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BAL") (:form . "BAL") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 115)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 158) (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 171)\n  (:start . 159) (:id . 65))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 197)\n  (:start . 187) (:id . 69))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 203) (:start . 198)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 71))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 213)\n  (:start . 208) (:id . 72))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 225)\n  (:start . 214) (:id . 73))\n ((:tag . "NN") (:stem . "phagocyte") (:form . "phagocyte") (:end . 235)\n  (:start . 226) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 240) (:start . 236)\n  (:id . 75))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 245) (:start . 241)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s541.3) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005005@unknown@formal@none@1@S@We found IL-2Ralpha expression to be increased in BAL cells from involved sites of active pulmonary tuberculosis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bal") (:form . "BAL") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 112)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s541.4) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005006@unknown@formal@none@1@S@Expression of the alpha-chain of IL-2Ralpha on peripheral blood monocytes (PBM) was induced by M. tuberculosis by flow cytometry evaluation.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PBM") (:form . "PBM") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 110)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s541.5) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005007@unknown@formal@none@1@S@Northern analysis demonstrated increased IL-2Ralpha gene expression after stimulation with M. tuberculosis which was further induced by interferon-gamma (IFN-gamma).@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 51)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 73) (:start . 68)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 85)\n  (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 93) (:start . 91)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 106)\n  (:start . 94) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 55))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 124)\n  (:start . 117) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 132)\n  (:start . 125) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 152) (:start . 136) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 163)\n  (:start . 154) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s541.6) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005008@unknown@formal@none@1@S@The IL-2Ralpha promoter containing the nuclear factor kappa B (NF-kappaB) site was transcriptionally induced by M. tuberculosis and this NF-kappaB site could confer inducibility to a heterologous herpes thymidine kinase (TK) promoter by M. tuberculosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 100) (:start . 83) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 177)\n  (:start . 165) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 182) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 195)\n  (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "herpes") (:form . "herpes") (:end . 202)\n  (:start . 196) (:id . 71))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 212)\n  (:start . 203) (:id . 72))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 219)\n  (:start . 213) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 221) (:start . 220)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TK") (:form . "TK") (:end . 223) (:start . 221)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 233)\n  (:start . 225) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 236) (:start . 234)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 239) (:start . 237)\n  (:id . 79))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 252)\n  (:start . 240) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s541.7) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005010@unknown@formal@none@1@S@Using antibodies against the p50 and p65 subunits of NF-kappaB in EMSAs, the involvement of both p50 and p65 proteins was further demonstrated.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 142)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s541.9) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005011@unknown@formal@none@1@S@Functional expression of the IL-2Ralpha on mononuclear phagocytes in M. tuberculosis infection may play an important immunomodulatory role in the host response.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 65)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 84)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 133) (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x541.10.1) (:span 95 98)))\n (:hscopes ((:id . :x541.10.1) (:span 95 159)))\n (:identifiers (:sid . :s541.10) (:did . :|10194184|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005012@unknown@formal@none@1@S@Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "CD") (:stem . "ix") (:form . "IX") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s542.1) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005013@unknown@formal@none@1@S@Glycoprotein (GP) IX is a subunit of the von Willebrand receptor, GPIb-V-IX, which mediates adhesion of platelets to the subendothelium of damaged blood vessels.@(((:tag . "NNP") (:stem . "Glycoprotein") (:form . "Glycoprotein") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GP") (:form . "GP") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ix") (:form . "IX") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 33)\n  (:start . 26) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "von") (:form . "von") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Willebrand") (:form . "Willebrand") (:end . 55)\n  (:start . 45) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GPIb-V-IX") (:form . "GPIb-V-IX") (:end . 75)\n  (:start . 66) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 113)\n  (:start . 104) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "subendothelium") (:form . "subendothelium")\n  (:end . 135) (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "damage") (:form . "damaged") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "NNS") (:stem . "vessel") (:form . "vessels") (:end . 160)\n  (:start . 153) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s542.2) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005014@unknown@formal@none@1@S@Previous characterization of the GPIX promoter identified a functional Ets site that, when disrupted, reduced promoter activity.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 25) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GPIX") (:form . "GPIX") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "disrupt") (:form . "disrupted") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s542.3) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005015@unknown@formal@none@1@S@However, the Ets protein(s) that regulated GPIX promoter expression was unknown.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein(s)") (:form . "protein(s)") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "regulate") (:form . "regulated") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "GPIX") (:form . "GPIX") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s542.4) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005016@unknown@formal@none@1@S@In this study, transient cotransfection of several GPIX promoter/reporter constructs into 293T kidney fibroblasts with a Fli-1 expression vector shows that the oncogenic protein Fli-1 can transactivate the GPIX promoter when an intact GPIX Ets site is present.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "GPIX") (:form . "GPIX") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter/reporter") (:form . "promoter/reporter")\n  (:end . 73) (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "293t") (:form . "293T") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kidney") (:form . "kidney") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 144)\n  (:start . 138) (:id . 61))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 177)\n  (:start . 170) (:id . 66))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 183)\n  (:start . 178) (:id . 67))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 187) (:start . 184)\n  (:id . 68))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 201) (:start . 188) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GPIX") (:form . "GPIX") (:end . 210) (:start . 206)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 219)\n  (:start . 211) (:id . 72))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 224) (:start . 220)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 227) (:start . 225)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 234)\n  (:start . 228) (:id . 75))\n ((:tag . "NNP") (:stem . "GPIX") (:form . "GPIX") (:end . 239) (:start . 235)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 243) (:start . 240)\n  (:id . 77))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 248) (:start . 244)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 251) (:start . 249)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 259)\n  (:start . 252) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s542.5) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005017@unknown@formal@none@1@S@In addition, Fli-1 binding of the GPIX Ets site was identified in antibody supershift experiments in nuclear extracts derived from hematopoietic human erythroleukemia cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GPIX") (:form . "GPIX") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 144) (:start . 131) (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 166) (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s542.6) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005018@unknown@formal@none@1@S@Comparative studies showed that Fli-1 was also able to transactivate the GPIbalpha and, to a lesser extent, the GPIIb promoter.@(((:tag . "JJ") (:stem . "comparative") (:form . "Comparative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 26) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GPIbalpha") (:form . "GPIbalpha") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 99) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "GPIIb") (:form . "GPIIb") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s542.7) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005020@unknown@formal@none@1@S@In addition, expression of Fli-1 was identified immunohistochemically in megakaryocytes derived from CD34(+) cells treated with the megakaryocyte differentiation and proliferation factor, thrombopoietin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Fli-1") (:form . "Fli-1") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "immunohistochemically")\n  (:form . "immunohistochemically") (:end . 69) (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 87) (:start . 73) (:id . 52))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 145) (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 161) (:start . 146) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 179) (:start . 166) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 186)\n  (:start . 180) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 65))\n ((:tag . "NN") (:stem . "thrombopoietin") (:form . "thrombopoietin")\n  (:end . 202) (:start . 188) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s542.9) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005021@unknown@formal@none@1@S@These results suggest that Fli-1 is likely to regulate lineage-specific genes during megakaryocytopoiesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 71) (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "megakaryocytopoiesis")\n  (:form . "megakaryocytopoiesis") (:end . 105) (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x542.10.1) (:span 36 42))\n  ((:id . :x542.10.2) (:span 14 21)))\n (:hscopes ((:id . :x542.10.1) (:span 27 105))\n  ((:id . :x542.10.2) (:span 14 105)))\n (:identifiers (:sid . :s542.10) (:did . :|10194443|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005022@unknown@formal@none@1@S@Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 58) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 120) (:start . 106) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 135)\n  (:start . 124) (:id . 57))\n ((:tag . "NNP") (:stem . "Saimiri") (:form . "Saimiri") (:end . 143)\n  (:start . 136) (:id . 58))\n ((:tag . "NNP") (:stem . "STP") (:form . "STP") (:end . 147) (:start . 144)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s543.1) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005023@unknown@formal@none@1@S@The STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "STP") (:form . "STP") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "oncoprotein") (:form . "oncoproteins") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "saimiri") (:form . "saimiri") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HVS") (:form . "HVS") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subgroup") (:form . "subgroup") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subgroup") (:form . "subgroup") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "CD") (:stem . "488") (:form . "488") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 127)\n  (:start . 121) (:id . 66))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 138)\n  (:start . 128) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 149)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 158)\n  (:start . 150) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 185) (:start . 166) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 192)\n  (:start . 186) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 198) (:start . 194)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 201) (:start . 200)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 78))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 204) (:start . 203)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 80))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 208) (:start . 206)\n  (:id . 81))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 210) (:start . 209)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s543.2) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005024@unknown@formal@none@1@S@Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pxqxt/s") (:form . "PXQXT/S") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stp-a11") (:form . "STP-A11") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s543.3) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005025@unknown@formal@none@1@S@In addition, a somewhat divergent region of STP-C488 is critical for TRAF association.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "somewhat") (:form . "somewhat") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stp-c488") (:form . "STP-C488") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s543.4) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005026@unknown@formal@none@1@S@Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stp-c488") (:form . "STP-C488") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAFs") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s543.5) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005027@unknown@formal@none@1@S@The HVS STP-C488 P10-->R mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HVS") (:form . "HVS") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "STP-C488") (:form . "STP-C488") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "P10–>R") (:form . "P10–>R") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 82) (:start . 68) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "interleukin-2-independent")\n  (:form . "interleukin-2-independent") (:end . 111) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 118)\n  (:start . 112) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 129)\n  (:start . 123) (:id . 57))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 149)\n  (:start . 140) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 153) (:start . 150)\n  (:id . 60))\n ((:tag . "NN") (:stem . "marmoset") (:form . "marmoset") (:end . 162)\n  (:start . 154) (:id . 61))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 175) (:start . 163) (:id . 62))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 190) (:start . 176) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 199)\n  (:start . 194) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 211) (:start . 207)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s543.6) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005028@unknown@formal@none@1@S@The STP-C488 P10-->R mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stp-c488") (:form . "STP-C488") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "P10–>R") (:form . "P10–>R") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rat-1") (:form . "Rat-1") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 81) (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 117) (:start . 103) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 129)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 158) (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 165)\n  (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s543.7) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005030@unknown@formal@none@1@S@Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 47) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "marmoset") (:form . "marmoset") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 127) (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "rodent") (:form . "rodent") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 171)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x543.9.1) (:span 85 88)))\n (:hscopes ((:id . :x543.9.1) (:span 85 171)))\n (:identifiers (:sid . :s543.9) (:did . :|10196286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005031@unknown@formal@none@1@S@Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NFkappaB activation in T lymphocytes during aging: evidence for altered IkappaB-alpha phosphorylation and degradation.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "phenylarsine") (:form . "phenylarsine") (:end . 70)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 130) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 139)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 165) (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 181) (:start . 166) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 66))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 197)\n  (:start . 186) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s544.1) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005032@unknown@formal@none@1@S@Nuclear Factor kappa B (NFkappaB) is a critical regulator of several genes involved in immune and inflammatory responses.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "Factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 110)\n  (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s544.2) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005033@unknown@formal@none@1@S@Treatment of T cells with a variety of stimuli, including TNF-alpha, leads to the translocation of the active p65-50 heterodimer to the nucleus, albeit at a lower level in T cells from the elderly.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 95) (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "p65-50") (:form . "p65-50") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 128)\n  (:start . 117) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "IN") (:stem . "albeit") (:form . "albeit") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 162) (:start . 157)\n  (:id . 71))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 168)\n  (:start . 163) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 179)\n  (:start . 174) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 196)\n  (:start . 189) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s544.3) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005034@unknown@formal@none@1@S@We demonstrate here that pretreatment with PAO results in the inhibition of NFkappaB induction in TNF-alpha treated T cells, suggesting a role for PAO-sensitive phosphatase in the activation of the NFkappaB via this pathway in human T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "treated") (:form . "treated") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "pao-sensitive") (:form . "PAO-sensitive")\n  (:end . 160) (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 172)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 190)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "nfkappab") (:form . "NFkappaB") (:end . 206)\n  (:start . 198) (:id . 73))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 215) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 223)\n  (:start . 216) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 232)\n  (:start . 227) (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 234) (:start . 233)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x544.4.1) (:span 125 135)))\n (:hscopes ((:id . :x544.4.1) (:span 125 240)))\n (:identifiers (:sid . :s544.4) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005035@unknown@formal@none@1@S@Furthermore, it demonstrates that aging does not influence the sensitivity of this phosphatase.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x544.5.1) (:span 45 48)))\n (:nscopes ((:id . :x544.5.1) (:span 45 94)))\n (:identifiers (:sid . :s544.5) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005036@unknown@formal@none@1@S@Treatment with DMP prior to treatment with PAO and TNF abolishes the inhibition induced by PAO, in T cells from both young and old donors, alike.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DMP") (:form . "DMP") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "old") (:form . "old") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 137)\n  (:start . 131) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "RB") (:stem . "alike") (:form . "alike") (:end . 144)\n  (:start . 139) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s544.6) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005037@unknown@formal@none@1@S@Finally, we demonstrate that a failure to degrade IkappaB-alpha in cytosols of TNF-treated T cells pretreated with PAO is due to its interference with the phosphorylation of IkappaB-alpha and not due to its inhibitory effect on proteasomal degradation.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "degrade") (:form . "degrade") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cytosol") (:form . "cytosols") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "tnf-treated") (:form . "TNF-treated") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 145)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 170) (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 187) (:start . 174) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 217)\n  (:start . 207) (:id . 76))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 224)\n  (:start . 218) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 227) (:start . 225)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "proteasomal") (:form . "proteasomal") (:end . 239)\n  (:start . 228) (:id . 79))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 251)\n  (:start . 240) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x544.7.1) (:span 192 195))\n  ((:id . :x544.7.2) (:span 31 38)))\n (:nscopes ((:id . :x544.7.1) (:span 192 251))\n  ((:id . :x544.7.2) (:span 31 118)))\n (:identifiers (:sid . :s544.7) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005038@unknown@formal@none@1@S@These data collectively suggest that PAO interferes with the phosphorylation and the regulated degradation of IkappaB-alpha, induced by TNF, without affecting the chymotryptic activity of the proteasome, independent of age.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "collectively") (:form . "collectively") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 76) (:start . 61) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 106)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 123) (:start . 110) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 132)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "chymotryptic") (:form . "chymotryptic") (:end . 175)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 184)\n  (:start . 176) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 202)\n  (:start . 192) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 215)\n  (:start . 204) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 73))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 222) (:start . 219)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x544.8.2) (:span 24 31)))\n (:ncues ((:id . :x544.8.1) (:span 141 148)))\n (:hscopes ((:id . :x544.8.2) (:span 24 222)))\n (:nscopes ((:id . :x544.8.1) (:span 141 202)))\n (:identifiers (:sid . :s544.8) (:did . :|10197731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005040@unknown@formal@none@1@S@Lipopolysaccharide (LPS) is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor alpha (TNF-alpha) and other inflammatory mediators.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "stimulator") (:form . "stimulator") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 161)\n  (:start . 149) (:id . 67))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s545.2) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005041@unknown@formal@none@1@S@Given the deleterious effects to the host of TNF-alpha, it has been postulated that TNF-alpha gene expression must be tightly regulated.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "deleterious") (:form . "deleterious") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "postulate") (:form . "postulated") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s545.3) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005042@unknown@formal@none@1@S@The nature of the nuclear factor(s) that control TNF-alpha gene transcription in humans remains obscure, although NF-kappaB has been suggested.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "factor(s)") (:form . "factor(s)") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "obscure") (:form . "obscure") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x545.4.1) (:span 133 142)))\n (:hscopes ((:id . :x545.4.1) (:span 114 142)))\n (:identifiers (:sid . :s545.4) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005043@unknown@formal@none@1@S@Our previous studies pertaining to macrophage response to LPS identified a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity, but lacks any known NF-kappaB-binding sites.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBG") (:stem . "pertain") (:form . "pertaining") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-550") (:form . "-550") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "CD") (:stem . "-487") (:form . "-487") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 162) (:start . 158)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 187) (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 196)\n  (:start . 188) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 207)\n  (:start . 202) (:id . 72))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 211) (:start . 208)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 217)\n  (:start . 212) (:id . 74))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 235) (:start . 218) (:id . 75))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 241)\n  (:start . 236) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x545.5.1) (:span 202 207)))\n (:nscopes ((:id . :x545.5.1) (:span 202 241)))\n (:identifiers (:sid . :s545.5) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005044@unknown@formal@none@1@S@We have used this DNA fragment to isolate and purify a 60-kDa protein binding to this fragment and obtained its amino-terminal sequence, which was used to design degenerate probes to screen a cDNA library from THP-1 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "purify") (:form . "purify") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "60-kda") (:form . "60-kDa") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 126) (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "VB") (:stem . "design") (:form . "design") (:end . 161)\n  (:start . 155) (:id . 69))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 172)\n  (:start . 162) (:id . 70))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 179)\n  (:start . 173) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "VB") (:stem . "screen") (:form . "screen") (:end . 189)\n  (:start . 183) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 191) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 204)\n  (:start . 197) (:id . 76))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 209) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 215)\n  (:start . 210) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 221)\n  (:start . 216) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s545.6) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005045@unknown@formal@none@1@S@A novel cDNA clone (1.8 kb) was isolated and fully sequenced.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1.8") (:form . "1.8") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 40)\n  (:start . 32) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 50) (:start . 45)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 60)\n  (:start . 51) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s545.7) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005046@unknown@formal@none@1@S@Characterization of this cDNA clone revealed that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF).@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "name") (:form . "name") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 139)\n  (:start . 128) (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LITAF") (:form . "LITAF") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s545.8) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005047@unknown@formal@none@1@S@Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LITAF") (:form . "LITAF") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s545.9) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005048@unknown@formal@none@1@S@In addition, high level of expression of LITAF mRNA was observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes, and the spleen.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LITAF") (:form . "LITAF") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "placenta") (:form . "placenta") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s545.10) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005050@unknown@formal@none@1@S@Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LITAF") (:form . "LITAF") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "propose") (:form . "proposes") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 142)\n  (:start . 133) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 153)\n  (:start . 146) (:id . 67))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 163)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x545.12.1) (:span 25 32)))\n (:hscopes ((:id . :x545.12.1) (:span 25 179)))\n (:identifiers (:sid . :s545.12) (:did . :|10200294|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005051@unknown@formal@none@1@S@Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line.@(((:tag . "NN") (:stem . "engagement") (:form . "Engagement") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NKL") (:form . "NKL") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s546.1) (:did . :|10201929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005052@unknown@formal@none@1@S@NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis.@(((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "fast") (:form . "fast") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s546.2) (:did . :|10201929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005053@unknown@formal@none@1@S@Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "multiplex") (:form . "multiplex") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 104)\n  (:start . 92) (:id . 57))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNP") (:stem . "NKL") (:form . "NKL") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 173)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 187)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 197)\n  (:start . 188) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 205)\n  (:start . 198) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 207) (:start . 206)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "AP)-1") (:form . "AP)-1") (:end . 212)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 226) (:start . 213) (:id . 76))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 233)\n  (:start . 227) (:id . 77))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 239)\n  (:start . 234) (:id . 78))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 244) (:start . 240)\n  (:id . 79))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 247) (:start . 245)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 252) (:start . 248)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 253) (:start . 252)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "FosB") (:form . "FosB") (:end . 258) (:start . 254)\n  (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 84))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 268)\n  (:start . 263) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s546.3) (:did . :|10201929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005054@unknown@formal@none@1@S@In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jun-Fos") (:form . "Jun-Fos") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 92) (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 114)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 143)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 156)\n  (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s546.4) (:did . :|10201929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005055@unknown@formal@none@1@S@Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity.@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "JJ") (:stem . "immunoglobulin-like")\n  (:form . "immunoglobulin-like") (:end . 39) (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "transcript-2/leukocyte")\n  (:form . "transcript-2/leukocyte") (:end . 62) (:start . 40) (:id . 45))\n ((:tag . "JJ") (:stem . "ig-like") (:form . "Ig-like") (:end . 70)\n  (:start . 63) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 47))\n ((:tag . 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"with") (:end . 196) (:start . 192)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 207)\n  (:start . 200) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 215) (:start . 211)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "FosB") (:form . "FosB") (:end . 221) (:start . 217)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 226) (:start . 223)\n  (:id . 76))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 232)\n  (:start . 227) (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . 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"activity") (:end . 299)\n  (:start . 291) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 300) (:start . 299)\n  (:id . 89)))@@@1@48@((:ncues ((:id . :x546.5.1) (:span 262 269))\n  ((:id . :x546.5.2) (:span 200 207)))\n (:nscopes ((:id . :x546.5.1) (:span 262 299))\n  ((:id . :x546.5.2) (:span 200 246)))\n (:identifiers (:sid . :s546.5) (:did . :|10201929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005056@unknown@formal@none@1@S@Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . 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"programs") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 191)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 202) (:start . 198)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 213)\n  (:start . 203) (:id . 76))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 223)\n  (:start . 214) (:id . 77))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 227) (:start . 224)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 231) (:start . 228)\n  (:id . 79))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 237)\n  (:start . 232) (:id . 80))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 239) (:start . 238)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 249)\n  (:start . 240) (:id . 82))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 257)\n  (:start . 250) (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 261) (:start . 258)\n  (:id . 84))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 266) (:start . 262)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 272)\n  (:start . 267) (:id . 86))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 283)\n  (:start . 273) (:id . 87))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 286) (:start . 284)\n  (:id . 88))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 291) (:start . 287)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x546.6.1) (:span 17 30)))\n (:hscopes ((:id . :x546.6.1) (:span 17 291)))\n (:identifiers (:sid . :s546.6) (:did . :|10201929|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005057@unknown@formal@none@1@S@Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 73) (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s547.1) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005058@unknown@formal@none@1@S@To continue our investigation of the cellular events that occur following human CMV (HCMV) infection, we focused on the regulation of cellular activation following viral binding to human monocytes.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "continue") (:form . "continue") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "focus") (:form . "focused") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 130)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 163)\n  (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 180) (:start . 178)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 196)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s547.2) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005060@unknown@formal@none@1@S@Next, we demonstrated that these viral ligands directly up-regulated monocyte gene expression upon their binding to their appropriate cellular receptors.@(((:tag . "RB") (:stem . "next") (:form . "Next") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 21)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "up-regulate") (:form . "up-regulated") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 104)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 133)\n  (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 152)\n  (:start . 143) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s547.4) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005061@unknown@formal@none@1@S@We then investigated if HCMV binding also resulted in the translation and secretion of cytokines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x547.5.1) (:span 21 23)))\n (:hscopes ((:id . :x547.5.1) (:span 21 96)))\n (:identifiers (:sid . :s547.5) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005062@unknown@formal@none@1@S@Our results showed that HCMV binding to monocytes resulted in the production and release of IL-1beta protein.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s547.6) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005063@unknown@formal@none@1@S@Because these induced gene products have NF-kappaB sites in their promoter regions, we next examined whether there was an up-regulation of nuclear NF-kappaB levels.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 65)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 135) (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 156)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x547.7.1) (:span 101 108)))\n (:hscopes ((:id . :x547.7.1) (:span 101 163)))\n (:identifiers (:sid . :s547.7) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005064@unknown@formal@none@1@S@These experiments showed that, in fact, NF-kappaB was translocated to the nucleus following viral binding or purified viral ligand binding.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 24) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s547.8) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005065@unknown@formal@none@1@S@Changes in IkappaBalpha levels correlated with the changes in NF-kappaB translocation.@(((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s547.9) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005066@unknown@formal@none@1@S@Lastly, we demonstrated that p38 kinase activity played a central role in IL-1beta production and that it was rapidly up-regulated following infection.@(((:tag . "RB") (:stem . "lastly") (:form . "Lastly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "play") (:form . "played") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 130)\n  (:start . 118) (:id . 62))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s547.10) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005067@unknown@formal@none@1@S@These results support our hypothesis that HCMV initiates a signal transduction pathway that leads to monocyte activation and pinpoints a potential mechanism whereby HCMV infection of monocytes can result in profound pathogenesis, especially in chronic inflammatory-type conditions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 78)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "pinpoint") (:form . "pinpoints") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 156)\n  (:start . 147) (:id . 63))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 169) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 179)\n  (:start . 170) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 192)\n  (:start . 183) (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 196) (:start . 193)\n  (:id . 69))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 203)\n  (:start . 197) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 215)\n  (:start . 207) (:id . 72))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 228)\n  (:start . 216) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 229) (:start . 228)\n  (:id . 74))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 240)\n  (:start . 230) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 243) (:start . 241)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 251)\n  (:start . 244) (:id . 77))\n ((:tag . "JJ") (:stem . "inflammatory-type") (:form . "inflammatory-type")\n  (:end . 269) (:start . 252) (:id . 78))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 280)\n  (:start . 270) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x547.11.1) (:span 193 196))\n  ((:id . :x547.11.2) (:span 137 146)) ((:id . :x547.11.3) (:span 26 36)))\n (:hscopes ((:id . :x547.11.1) (:span 193 280))\n  ((:id . :x547.11.2) (:span 137 280)) ((:id . :x547.11.3) (:span 26 280)))\n (:identifiers (:sid . :s547.11) (:did . :|10202024|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005068@unknown@formal@none@1@S@Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae.@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 69)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Chlamydia") (:form . "Chlamydia") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "NNP") (:stem . "pneumoniae") (:form . "pneumoniae") (:end . 105)\n  (:start . 95) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s548.1) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005070@unknown@formal@none@1@S@Recently, its presence has been demonstrated in atherosclerotic lesions.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 63) (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s548.3) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005071@unknown@formal@none@1@S@In this study, we characterized C. pneumoniae-mediated activation of endothelial cells and demonstrated an enhanced expression of endothelial adhesion molecules followed by subsequent rolling, adhesion, and transmigration of leukocytes (monocytes, granulocytes).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 31) (:start . 18) (:id . 47))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pneumoniae-mediated")\n  (:form . "pneumoniae-mediated") (:end . 54) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 103)\n  (:start . 91) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 141)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 150)\n  (:start . 142) (:id . 61))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 160)\n  (:start . 151) (:id . 62))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 169)\n  (:start . 161) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 183)\n  (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "rolling") (:form . "rolling") (:end . 191)\n  (:start . 184) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 67))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 201)\n  (:start . 193) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transmigration") (:form . "transmigration")\n  (:end . 221) (:start . 207) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 235)\n  (:start . 225) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 246)\n  (:start . 237) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 260)\n  (:start . 248) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 261) (:start . 260)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s548.4) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005072@unknown@formal@none@1@S@These effects were blocked by mAbs against endothelial and/or leukocyte adhesion molecules (beta1 and beta2 integrins).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "beta1") (:form . "beta1") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "beta2") (:form . "beta2") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s548.5) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005073@unknown@formal@none@1@S@Additionally, activation of different signal transduction pathways in C. pneumoniae-infected endothelial cells was shown: protein tyrosine phosphorylation, up-regulation of phosphorylated p42/p44 mitogen-activated protein kinase, and NF-kappaB activation/translocation occurred within 10-15 min.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pneumoniae-infected")\n  (:form . "pneumoniae-infected") (:end . 92) (:start . 73) (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 104)\n  (:start . 93) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 120)\n  (:start . 115) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 121) (:start . 120)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 138)\n  (:start . 130) (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 154) (:start . 139) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 61))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 169) (:start . 156) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 187) (:start . 173) (:id . 64))\n ((:tag . "NN") (:stem . "p42/p44") (:form . "p42/p44") (:end . 195)\n  (:start . 188) (:id . 65))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 213) (:start . 196) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 221)\n  (:start . 214) (:id . 67))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 228)\n  (:start . 222) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 229) (:start . 228)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 233) (:start . 230)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 243)\n  (:start . 234) (:id . 71))\n ((:tag . "NN") (:stem . "activation/translocation")\n  (:form . "activation/translocation") (:end . 268) (:start . 244) (:id . 72))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 277)\n  (:start . 269) (:id . 73))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 284)\n  (:start . 278) (:id . 74))\n ((:tag . "CD") (:stem . "10-15") (:form . "10-15") (:end . 290)\n  (:start . 285) (:id . 75))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 294) (:start . 291)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s548.6) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005074@unknown@formal@none@1@S@Increased mRNA and surface expression of E-selectin, ICAM-1, and VCAM-1 were noted within hours.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s548.7) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005075@unknown@formal@none@1@S@Thus, C. pneumoniae triggers a cascade of events that could lead to endothelial activation, inflammation, and thrombosis, which in turn may result in or may promote atherosclerosis.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "FW") (:stem . "pneumoniae") (:form . "pneumoniae") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 104)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "thrombosis") (:form . "thrombosis") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 146)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 152) (:start . 150)\n  (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 164)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 180) (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x548.8.1) (:span 153 156))\n  ((:id . :x548.8.3) (:span 150 152)) ((:id . :x548.8.2) (:span 136 139))\n  ((:id . :x548.8.4) (:span 54 59)))\n (:hscopes ((:id . :x548.8.1) (:span 153 180))\n  ((:id . :x548.8.3) (:span 136 149)) ((:id . :x548.8.2) (:span 136 180))\n  ((:id . :x548.8.4) (:span 54 180)))\n (:identifiers (:sid . :s548.8) (:did . :|10202027|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005076@unknown@formal@none@1@S@Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes.@(((:tag . "JJ") (:stem . "extracellular-regulated")\n  (:form . "Extracellular-regulated") (:end . 23) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 30)\n  (:start . 24) (:id . 43))\n ((:tag . "CD") (:stem . "1/2") (:form . "1/2") (:end . 34) (:start . 31)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s549.1) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005077@unknown@formal@none@1@S@In the present study we investigated the possible involvement of the mitogen-activated protein kinase family members extracellular-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) in mediating IL-6 gene expression in human monocytes, in particular their role in enhancing NF-kappa B activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"activity") (:end . 306)\n  (:start . 298) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x549.2.1) (:span 41 49)))\n (:hscopes ((:id . :x549.2.1) (:span 41 247)))\n (:identifiers (:sid . :s549.2) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005078@unknown@formal@none@1@S@Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins.@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "secrete") (:form . "secreted") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "VBD") (:stem . "coincide") (:form . "coincided") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 154)\n  (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 171)\n  (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 68))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 188) (:start . 186)\n  (:id . 69))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 193) (:start . 189)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 217) (:start . 202) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 232)\n  (:start . 222) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "ERK1/2") (:form . "ERK1/2") (:end . 246)\n  (:start . 240) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 250) (:start . 247)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 254) (:start . 251)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 263)\n  (:start . 255) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s549.3) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005080@unknown@formal@none@1@S@Transient overexpression of inactive mutants of either Raf-1 or JNK1 showed that both pathways were involved in kappa B-dependent IL-6 promoter activity.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "Raf-1") (:form . "Raf-1") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "JNK1") (:form . "JNK1") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 75) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s549.5) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005081@unknown@formal@none@1@S@By using PD98059, we demonstrated that the Raf1/MEK1/ERK1/2 pathway did not affect the DNA binding of NF-kappa B but, rather, acted at the level of transcriptional activity of NF-kappa B.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pd98059") (:form . "PD98059") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 33)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Raf1/MEK1/ERK1/2") (:form . "Raf1/MEK1/ERK1/2")\n  (:end . 59) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "act") (:form . "acted") (:end . 131) (:start . 126)\n  (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 163) (:start . 148) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 172)\n  (:start . 164) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 184)\n  (:start . 176) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x549.6.1) (:span 72 75)))\n (:nscopes ((:id . :x549.6.1) (:span 72 112)))\n (:identifiers (:sid . :s549.6) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005082@unknown@formal@none@1@S@Interestingly, it was shown that NF-kappa B-mediated gene transcription, both in the context of the IL-6 promoter as well as on its own, was dependent on both serine kinase activity and interaction with c-Jun protein.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 150)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 158) (:start . 154)\n  (:id . 71))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 165)\n  (:start . 159) (:id . 72))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 172)\n  (:start . 166) (:id . 73))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 181)\n  (:start . 173) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 75))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 197)\n  (:start . 186) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 202) (:start . 198)\n  (:id . 77))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 216)\n  (:start . 209) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s549.7) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005083@unknown@formal@none@1@S@We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ERK1/2") (:form . "ERK1/2") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pathway-dependent") (:form . "pathway-dependent")\n  (:end . 131) (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 154)\n  (:start . 146) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 172) (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 181)\n  (:start . 173) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s549.8) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005084@unknown@formal@none@1@S@Our results suggest that the JNK pathway may regulate NF-kappa B-mediated gene transcription through its phosphorylation and activation of c-Jun.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 120) (:start . 105) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x549.9.1) (:span 41 44)) ((:id . :x549.9.2) (:span 12 19)))\n (:hscopes ((:id . :x549.9.1) (:span 41 144))\n  ((:id . :x549.9.2) (:span 12 144)))\n (:identifiers (:sid . :s549.9) (:did . :|10202034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005085@unknown@formal@none@1@S@Differential induction of interferon (IFN)-inducible protein 10 following differentiation of a monocyte, macrophage cell lineage is related to the changes of nuclear proteins bound to IFN stimulus response element and kappaB sites.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "IFN)-inducible") (:form . "IFN)-inducible")\n  (:end . 52) (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 89) (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 139)\n  (:start . 132) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 205)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 213)\n  (:start . 206) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 224)\n  (:start . 218) (:id . 74))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 230)\n  (:start . 225) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s550.1) (:did . :|10202178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005086@unknown@formal@none@1@S@We examined chemokine gene expression following the differentiation of a monocyte, macrophage cell lineage.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s550.2) (:did . :|10202178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005087@unknown@formal@none@1@S@The human monoblastic cell line, U937 was differentiated to macrophages by the treatment with either phorbol 12-myristate 13-acetate (PMA), retinoic acid (RA), or vitamin D3 (VitD3).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 56) (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 170)\n  (:start . 163) (:id . 72))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "VitD3") (:form . "VitD3") (:end . 180)\n  (:start . 175) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s550.3) (:did . :|10202178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005088@unknown@formal@none@1@S@The gene expression of interferon (IFN)-inducible protein 10 (IP-10) (a CXC chemokine) was markedly augmented by the IFNgamma treatment in PMA- or RA-differentiated U937 cells, but only marginally in undifferentiated or VitD3-treated cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "IFN)-inducible") (:form . "IFN)-inducible")\n  (:end . 49) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IP-10") (:form . "IP-10") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CXC") (:form . "CXC") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "VBN") (:stem . "augment") (:form . "augmented") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 125)\n  (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 135)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PMA-") (:form . "PMA-") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "ra-differentiated") (:form . "RA-differentiated")\n  (:end . 164) (:start . 147) (:id . 69))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "RB") (:stem . "marginally") (:form . "marginally") (:end . 196)\n  (:start . 186) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "undifferentiated") (:form . "undifferentiated")\n  (:end . 216) (:start . 200) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 219) (:start . 217)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "vitd3-treated") (:form . "VitD3-treated")\n  (:end . 233) (:start . 220) (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 239)\n  (:start . 234) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s550.4) (:did . :|10202178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005090@unknown@formal@none@1@S@Increased expression of IFNgamma-induced IP-10 mRNA following the differentiation of U937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to IFN stimulus response element (ISRE) and kB sites, suggesting that these nuclear proteins may determine the IP-10 mRNA inducibility by IFNgamma.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ifngamma-induced") (:form . "IFNgamma-induced")\n  (:end . 40) (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "IP-10") (:form . "IP-10") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . 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5005091@unknown@formal@none@1@S@Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.@(((:tag . "JJ") (:stem . "fludarabine-induced")\n  (:form . "Fludarabine-induced") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 37) (:start . 20) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 51)\n  (:start . 41) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 67)\n  (:start . 57) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 76) (:start . 71)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 86)\n  (:start . 77) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s551.1) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005092@unknown@formal@none@1@S@Fludarabine is a nucleoside analog used in the treatment of hematologic malignancies that can induce severe and prolonged immunosuppression.@(((:tag . "NNP") (:stem . "Fludarabine") (:form . "Fludarabine") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nucleoside") (:form . "nucleoside") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "analog") (:form . "analog") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hematologic") (:form . "hematologic") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 139) (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s551.2) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005093@unknown@formal@none@1@S@Although it can be incorporated into the DNA of dividing cells, fludarabine is also a potent inhibitor of cells with a low growth fraction, thus it must have other mechanisms of action.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "incorporate") (:form . "incorporated") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "divide") (:form . "dividing") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fludarabine") (:form . "fludarabine") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 129)\n  (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 144) (:start . 140)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 152) (:start . 148)\n  (:id . 70))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 157) (:start . 153)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 163)\n  (:start . 158) (:id . 72))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 174)\n  (:start . 164) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 184)\n  (:start . 178) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s551.3) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005094@unknown@formal@none@1@S@STAT1, which is activated in response to many lymphocyte-activating cytokines including the interferons, is essential for cell-mediated immunity, as the absence of this protein is associated with prominent defects in the ability to control viral infections.@(((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphocyte-activating")\n  (:form . "lymphocyte-activating") (:end . 67) (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "interferon") (:form . "interferons") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 168) (:start . 164)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 190)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 195) (:start . 191)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 205)\n  (:start . 196) (:id . 72))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 213)\n  (:start . 206) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 228)\n  (:start . 221) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 231) (:start . 229)\n  (:id . 77))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 239)\n  (:start . 232) (:id . 78))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 245)\n  (:start . 240) (:id . 79))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 256)\n  (:start . 246) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x551.4.1) (:span 153 160)))\n (:nscopes ((:id . :x551.4.1) (:span 153 176)))\n (:identifiers (:sid . :s551.4) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005095@unknown@formal@none@1@S@Here we show that fludarabine, but not the immunosuppressant cyclosporine A, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fludarabine") (:form . "fludarabine") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 60) (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 106) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "stat1-dependent") (:form . "STAT1-dependent")\n  (:end . 146) (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 165) (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 175)\n  (:start . 169) (:id . 66))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 183)\n  (:start . 176) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 208)\n  (:start . 197) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x551.5.1) (:span 35 38)))\n (:nscopes ((:id . :x551.5.1) (:span 35 75)))\n (:identifiers (:sid . :s551.5) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005096@unknown@formal@none@1@S@Fludarabine caused a specific depletion of STAT1 protein (and mRNA) but not of other STATs.@(((:tag . "NNP") (:stem . "Fludarabine") (:form . "Fludarabine") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x551.6.1) (:span 72 75)))\n (:nscopes ((:id . :x551.6.1) (:span 72 90)))\n (:identifiers (:sid . :s551.6) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005097@unknown@formal@none@1@S@This loss of STAT1 was also seen in cells from patients treated with fludarabine in vivo.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fludarabine") (:form . "fludarabine") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s551.7) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005098@unknown@formal@none@1@S@Brief exposure to fludarabine led to a sustained loss of STAT1, analogous to the prolonged period of immunosuppression induced by exposure to the drug in vivo.@(((:tag . "JJ") (:stem . "brief") (:form . "Brief") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fludarabine") (:form . "fludarabine") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 118) (:start . 101) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s551.8) (:did . :|10202937|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005100@unknown@formal@none@1@S@Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.@(((:tag . "JJ") (:stem . "suppressive") (:form . "Suppressive") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 40) (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 47)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 68)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s552.1) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005101@unknown@formal@none@1@S@BACKGROUND: Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60).@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 94) (:start . 79) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "hsp60") (:form . "Hsp60") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x552.2.1) (:span 95 98)))\n (:hscopes ((:id . :x552.2.1) (:span 56 174)))\n (:identifiers (:sid . :s552.2) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005102@unknown@formal@none@1@S@The interactions of Hsp60-specific T cells with arterial endothelial cells (EC) require expression of both Hsp60 and certain adhesion molecules shown to be induced simultaneously in EC by mechanical and other types of stress.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hsp60-specific") (:form . "Hsp60-specific")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "arterial") (:form . "arterial") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hsp60") (:form . "Hsp60") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 178) (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 198)\n  (:start . 188) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 208)\n  (:start . 203) (:id . 74))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 214)\n  (:start . 209) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 76))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 224)\n  (:start . 218) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s552.3) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005103@unknown@formal@none@1@S@Recently, it was shown that suppression of T cell-mediated immune responses by cyclosporin A (CyA) enhanced atherosclerotic lesion formation in mice.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 58) (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 123) (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "lesion") (:form . "lesion") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 148)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s552.4) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005104@unknown@formal@none@1@S@In contrast, aspirin was found to lower the risk of myocardial infarction in men.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "lower") (:form . "lower") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "myocardial") (:form . "myocardial") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "infarction") (:form . "infarction") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "man") (:form . "men") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s552.5) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005105@unknown@formal@none@1@S@These conflicting observations may be due to different effects of anti-inflammatory agents on adhesion molecule and Hsp expression in EC, respectively.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "conflict") (:form . "conflicting") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 83) (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hsp") (:form . "Hsp") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 150)\n  (:start . 138) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x552.6.1) (:span 31 34)))\n (:hscopes ((:id . :x552.6.1) (:span 31 150)))\n (:identifiers (:sid . :s552.6) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005106@unknown@formal@none@1@S@MATERIAL AND METHODS: In the present study, we analyzed the effects of CyA, aspirin, and indomethacin on T cell proliferation using a proliferation assay.@(((:tag . "NN") (:stem . "material") (:form . "MATERIAL") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 83)\n  (:start . 76) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 101)\n  (:start . 89) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 125) (:start . 112) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 131) (:start . 126)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 147) (:start . 134) (:id . 68))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 153)\n  (:start . 148) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s552.7) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005107@unknown@formal@none@1@S@To explore the expression of adhesion molecules, monocyte chemoattractant protein-1 (MCP-1), and Hsp60 in human umbilical vein endothelial cells (HUVECs), Northern blot analyses were used.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hsp60") (:form . "Hsp60") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 138)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 182) (:start . 178)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s552.8) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005108@unknown@formal@none@1@S@To examine the activation status of the transcription factors nuclear factor kappaB (NF-kappaB) and heat shock factor-1 (HSF-1), electrophoretic mobility shift assays were performed.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hsf-1") (:form . "HSF-1") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 144) (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 181)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s552.9) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005110@unknown@formal@none@1@S@Interestingly, CyA and indomethacin did not suppress tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression on HUVECs, whereas aspirin had an inhibitory effect.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 80)\n  (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "TNF-alpha)-induced") (:form . "TNF-alpha)-induced")\n  (:end . 100) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 118)\n  (:start . 110) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 139)\n  (:start . 133) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 148)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 156)\n  (:start . 149) (:id . 62))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 174)\n  (:start . 164) (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 181)\n  (:start . 175) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x552.11.1) (:span 40 43)))\n (:nscopes ((:id . :x552.11.1) (:span 40 139)))\n (:identifiers (:sid . :s552.11) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005111@unknown@formal@none@1@S@These observations correlated with the modulation of NF-kappaB activity in EC.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s552.12) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005112@unknown@formal@none@1@S@All agents tested induced expression of Hsp60 6 hr after application.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 17) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Hsp60") (:form . "Hsp60") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "application") (:form . "application") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s552.13) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005113@unknown@formal@none@1@S@In addition, aspirin and indomethacin, but not CyA, induced Hsp70 expression in HUVECs that correlated with induction of HSF-1 activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CyA") (:form . "CyA") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "hsp70") (:form . "Hsp70") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 102)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hsf-1") (:form . "HSF-1") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x552.14.1) (:span 43 46)))\n (:nscopes ((:id . :x552.14.1) (:span 43 50)))\n (:identifiers (:sid . :s552.14) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005114@unknown@formal@none@1@S@CONCLUSION: Our results show that the tested agents (except indomethacin) are inhibitors of the T cell-mediated immune response, as expected, that aspirin is an effective suppressor of adhesion molecule expression, and that all three agents can induce Hsp60 in HUVECs.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "test") (:form . 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(:end . 268) (:start . 267)\n  (:id . 88)))@@@1@47@((:ncues ((:id . :x552.15.1) (:span 53 59)))\n (:nscopes ((:id . :x552.15.1) (:span 53 72)))\n (:identifiers (:sid . :s552.15) (:did . :|10203577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005115@unknown@formal@none@1@S@These data provide the molecular basis for the notion that (1) part of the anti-atherogenic effect of aspirin may be due to the prevention of the adhesion of sensitized T cells to stressed EC; (2) that part of the atherosclerosis-promoting effect of CyA may be due to its potential as an inducer of Hsp60 expression and its inability to down-regulate adhesion molecule expression on EC; and (3) that down-regulation of MCP-1 expression by aspirin may result in decreased recruitment of monocytes into the arterial intima beneath stressed EC.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . 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5005116@unknown@formal@none@1@S@Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor.@(((:tag . "NNP") (:stem . "Amelioration") (:form . "Amelioration") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cerulein") (:form . "cerulein") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "pancreatitis") (:form . "pancreatitis") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "guamerin-derived") (:form . "guamerin-derived")\n  (:end . 61) (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 69)\n  (:start . 62) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "elastase") (:form . "elastase") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s553.1) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005117@unknown@formal@none@1@S@Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "pancreatitis") (:form . "pancreatitis") (:end . 95)\n  (:start . 83) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s553.2) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005118@unknown@formal@none@1@S@In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "elastase") (:form . "elastase") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "guamerin-derived") (:form . "guamerin-derived")\n  (:end . 71) (:start . 55) (:id . 53))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "improve") (:form . "improves") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 121)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cerulein-induced") (:form . "cerulein-induced")\n  (:end . 141) (:start . 125) (:id . 64))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "pancreatitis") (:form . "pancreatitis") (:end . 160)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s553.3) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005120@unknown@formal@none@1@S@The effects of GDSP were also measured on superoxide formation by activated human neutrophils.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "superoxide") (:form . "superoxide") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s553.5) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005121@unknown@formal@none@1@S@The effects of GDSP were compared with those of another elastase inhibitor, elastatinal.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "elastase") (:form . "elastase") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "elastatinal") (:form . "elastatinal") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s553.6) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005122@unknown@formal@none@1@S@GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein.@(((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "edema") (:form . "edema") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 69)\n  (:start . 57) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "acinar") (:form . "acinar") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "lipase") (:form . "lipase") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "amylase") (:form . "amylase") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 137)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cerulein") (:form . "cerulein") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s553.7) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005123@unknown@formal@none@1@S@GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA).@(((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "superoxide") (:form . "superoxide") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "N-formyl-methionine-leucine-phenyl-alanine")\n  (:form . "N-formyl-methionine-leucine-phenyl-alanine") (:end . 133)\n  (:start . 91) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "fMLP") (:form . "fMLP") (:end . 139) (:start . 135)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 143) (:start . 141)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 180) (:start . 144)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 182) (:start . 181)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 185) (:start . 182)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s553.8) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005124@unknown@formal@none@1@S@Elastatinal had some of the same effects as GDSP but was less potent and effective.@(((:tag . "NNP") (:stem . "Elastatinal") (:form . "Elastatinal") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s553.9) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005125@unknown@formal@none@1@S@These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GDSP") (:form . "GDSP") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "elastase") (:form . "elastase") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 110)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cerulein") (:form . "cerulein") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "pancreatitis") (:form . "pancreatitis") (:end . 139)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s553.10) (:did . :|10206480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005126@unknown@formal@none@1@S@Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 51) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "kinase-targeted") (:form . "kinase-targeted")\n  (:end . 75) (:start . 60) (:id . 50))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 98)\n  (:start . 90) (:id . 52))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 110)\n  (:start . 99) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HePTP") (:form . "HePTP") (:end . 117)\n  (:start . 112) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s554.1) (:did . :|10206983|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005127@unknown@formal@none@1@S@Activation of T lymphocytes to produce cytokines is regulated by the counterbalance of protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high degree of substrate specificity because of physical association with their targets.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "counterbalance") (:form . "counterbalance")\n  (:end . 83) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 103) (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 132) (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 145)\n  (:start . 133) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 151) (:start . 147)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 160)\n  (:start . 155) (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 192)\n  (:start . 183) (:id . 69))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 204)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 212)\n  (:start . 205) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 224)\n  (:start . 216) (:id . 73))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 236)\n  (:start . 225) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 241) (:start . 237)\n  (:id . 75))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 247)\n  (:start . 242) (:id . 76))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 255)\n  (:start . 248) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s554.2) (:did . :|10206983|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005128@unknown@formal@none@1@S@Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in suppression of T lymphocyte activation as measured by T cell antigen receptor-induced activation of transcription factors binding to the 5' promoter of the interleukin-2 gene.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 48) (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 60)\n  (:start . 49) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HePTP") (:form . "HePTP") (:end . 67) (:start . 62)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 107)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 130)\n  (:start . 122) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "JJ") (:stem . "receptor-induced") (:form . "receptor-induced")\n  (:end . 165) (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 176)\n  (:start . 166) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 193) (:start . 180) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 201)\n  (:start . 194) (:id . 67))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 209)\n  (:start . 202) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 212) (:start . 210)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 70))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 218) (:start . 217)\n  (:id . 71))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 219) (:start . 218)\n  (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 228)\n  (:start . 220) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 75))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 249) (:start . 236) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 254) (:start . 250)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s554.3) (:did . :|10206983|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005130@unknown@formal@none@1@S@In contrast, HePTP had no effects on N-terminal c-Jun kinase or on events upstream of the MAP kinases.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HePTP") (:form . "HePTP") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 73)\n  (:start . 67) (:id . 55))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x554.5.1) (:span 23 25)))\n (:nscopes ((:id . :x554.5.1) (:span 23 101)))\n (:identifiers (:sid . :s554.5) (:did . :|10206983|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005131@unknown@formal@none@1@S@The specificity of HePTP correlated with its physical association through its noncatalytic N terminus with Erk and another MAP kinase, p38, but not Jnk or other proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HePTP") (:form . "HePTP") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "noncatalytic") (:form . "noncatalytic") (:end . 90)\n  (:start . 78) (:id . 53))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Erk") (:form . "Erk") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Jnk") (:form . "Jnk") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 169)\n  (:start . 161) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x554.6.1) (:span 144 147)))\n (:nscopes ((:id . :x554.6.1) (:span 144 169)))\n (:identifiers (:sid . :s554.6) (:did . :|10206983|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005132@unknown@formal@none@1@S@We propose that HePTP plays a negative role in antigen receptor signaling by specifically regulating MAP kinases in the cytosol and at early time points of T cell activation before the activation-induced expression of nuclear dual-specific MAP kinase phosphatases.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HePTP") (:form . "HePTP") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 180)\n  (:start . 174) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 203) (:start . 185) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 214)\n  (:start . 204) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 225)\n  (:start . 218) (:id . 76))\n ((:tag . "JJ") (:stem . "dual-specific") (:form . "dual-specific")\n  (:end . 239) (:start . 226) (:id . 77))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 243) (:start . 240)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 250)\n  (:start . 244) (:id . 79))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 263)\n  (:start . 251) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x554.7.1) (:span 3 10)))\n (:hscopes ((:id . :x554.7.1) (:span 3 263)))\n (:identifiers (:sid . :s554.7) (:did . :|10206983|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005133@unknown@formal@none@1@S@Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes.@(((:tag . "NNP") (:stem . "Angiotensin") (:form . "Angiotensin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 44) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 87) (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 106)\n  (:start . 97) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s555.1) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005134@unknown@formal@none@1@S@The renin-angiotensin system may contribute to the pathogenesis of atherosclerosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "renin-angiotensin") (:form . "renin-angiotensin")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 28)\n  (:start . 22) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 82) (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x555.2.1) (:span 29 32)))\n (:hscopes ((:id . :x555.2.1) (:span 29 82)))\n (:identifiers (:sid . :s555.2) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005135@unknown@formal@none@1@S@A common feature of all stages of atherosclerosis is inflammation of the vessel wall.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 49) (:start . 34) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vessel") (:form . "vessel") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s555.3) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005136@unknown@formal@none@1@S@The transcription factor nuclear factor-kappaB (NF-kappaB) participates in most signaling pathways involved in inflammation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 46) (:start . 33) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 123)\n  (:start . 111) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s555.4) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005137@unknown@formal@none@1@S@This study therefore examined the effect of angiotensin (ANG) II on NF-kappaB activation in monocytic cells, a major cellular component of human atheroma, by electrophoretic mobility shift assay.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "angiotensin") (:form . "angiotensin") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ANG") (:form . "ANG") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "atheroma") (:form . "atheroma") (:end . 153)\n  (:start . 145) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 173) (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 182)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 188)\n  (:start . 183) (:id . 72))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s555.5) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005138@unknown@formal@none@1@S@ANG II, like TNFalpha, caused rapid activation of NF-kappaB in human mononuclear cells isolated from peripheral blood by Ficoll density gradient.@(((:tag . "NNP") (:stem . "ANG") (:form . "ANG") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 12) (:start . 8)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 21)\n  (:start . 13) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ficoll") (:form . "Ficoll") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "gradient") (:form . "gradient") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s555.6) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005140@unknown@formal@none@1@S@Specificity of ANG II-induced NF-kappaB activation was ascertained by supershift and competition experiments.@(((:tag . "NN") (:stem . "specificity") (:form . "Specificity") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ANG") (:form . "ANG") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ii-induced") (:form . "II-induced") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "ascertain") (:form . "ascertained") (:end . 66)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 96)\n  (:start . 85) (:id . 53))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 108)\n  (:start . 97) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s555.8) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005141@unknown@formal@none@1@S@Moreover, ANG II stimulated NF-kappaB activation in human monocytes, but not in lymphocytes from the same preparation.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "ANG") (:form . "ANG") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "preparation") (:form . "preparation") (:end . 117)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x555.9.1) (:span 73 76)))\n (:nscopes ((:id . :x555.9.1) (:span 73 117)))\n (:identifiers (:sid . :s555.9) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005142@unknown@formal@none@1@S@Together, the data demonstrate the ability of the vasoactive peptide ANG II to activate inflammatory pathways in human monocytes.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "vasoactive") (:form . "vasoactive") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "ANG") (:form . "ANG") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s555.10) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005143@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s555.11) (:did . :|10208867|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005144@unknown@formal@none@1@S@SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.@(((:tag . "JJ") (:stem . "shp2-interacting") (:form . "SHP2-interacting")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 30) (:start . 17) (:id . 43))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 38)\n  (:start . 31) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SIT") (:form . "SIT") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "disulfide-linked") (:form . "disulfide-linked")\n  (:end . 78) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s556.1) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005145@unknown@formal@none@1@S@T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "recruit") (:form . "recruit") (:end . 94)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "src") (:form . "src") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "SH)2") (:form . "SH)2") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "domain-containing") (:form . "domain-containing")\n  (:end . 131) (:start . 114) (:id . 58))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 145) (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 155)\n  (:start . 146) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 167) (:start . 163)\n  (:id . 63))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 176)\n  (:start . 168) (:id . 64))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 180) (:start . 177)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "tyrosine-based") (:form . "tyrosine-based")\n  (:end . 195) (:start . 181) (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 205)\n  (:start . 196) (:id . 67))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 212)\n  (:start . 206) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s556.2) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005146@unknown@formal@none@1@S@We describe here a novel molecule of this group termed SIT (SHP2 interacting transmembrane adaptor protein).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 54) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SIT") (:form . "SIT") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SHP2") (:form . "SHP2") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 76)\n  (:start . 65) (:id . 55))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s556.3) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005147@unknown@formal@none@1@S@SIT is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes.@(((:tag . "NN") (:stem . "sit") (:form . "SIT") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "disulfide-linked") (:form . "disulfide-linked")\n  (:end . 25) (:start . 9) (:id . 45))\n ((:tag . "JJ") (:stem . "homodimeric") (:form . "homodimeric") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s556.4) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005148@unknown@formal@none@1@S@After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 30) (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "src") (:form . "src") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "syk") (:form . "syk") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "sit") (:form . "SIT") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "recruit") (:form . "recruits") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "domain-containing") (:form . "domain-containing")\n  (:end . 118) (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 139)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "shp2") (:form . "SHP2") (:end . 144) (:start . 140)\n  (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "NN") (:stem . "immunoreceptor") (:form . "immunoreceptor")\n  (:end . 166) (:start . 152) (:id . 63))\n ((:tag . "JJ") (:stem . "tyrosine-based") (:form . "tyrosine-based")\n  (:end . 181) (:start . 167) (:id . 64))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 192)\n  (:start . 182) (:id . 65))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 198)\n  (:start . 193) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x556.5.1) (:span 42 50)))\n (:hscopes ((:id . :x556.5.1) (:span 42 79)))\n (:identifiers (:sid . :s556.5) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005150@unknown@formal@none@1@S@However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "shp2") (:form . "SHP2") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SIT") (:form . "SIT") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sit") (:form . "SIT") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 121)\n  (:start . 112) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 189) (:start . 185)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 200)\n  (:start . 190) (:id . 75))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 210)\n  (:start . 201) (:id . 76))\n ((:tag . "NN") (:stem . "shp2") (:form . "SHP2") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x556.7.1) (:span 83 93)))\n (:ncues ((:id . :x556.7.2) (:span 35 38)))\n (:hscopes ((:id . :x556.7.1) (:span 83 215)))\n (:nscopes ((:id . :x556.7.2) (:span 9 81)))\n (:identifiers (:sid . :s556.7) (:did . :|10209036|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005151@unknown@formal@none@1@S@GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.@(((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "grb2-related") (:form . "Grb2-related") (:end . 20)\n  (:start . 8) (:id . 45))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s557.1) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005152@unknown@formal@none@1@S@Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules.@(((:tag . "NN") (:stem . "propagation") (:form . "Propagation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s557.2) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005153@unknown@formal@none@1@S@SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development.@(((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "domain-containing") (:form . "domain-containing")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "CD") (:stem . "76") (:form . "76") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "slp-76") (:form . "SLP-76") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 177)\n  (:start . 167) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 189)\n  (:start . 181) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 200)\n  (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 202) (:start . 201)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 207) (:start . 203)\n  (:id . 77))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 219)\n  (:start . 208) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s557.3) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005154@unknown@formal@none@1@S@We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 42) (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "grb2-like") (:form . "Grb2-like") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "grb2-related") (:form . "Grb2-related") (:end . 107)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s557.4) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005155@unknown@formal@none@1@S@Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "distinguish") (:form . "distinguished") (:end . 82)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "proline-rich") (:form . "proline-rich") (:end . 117)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s557.5) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005156@unknown@formal@none@1@S@GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates.@(((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "coimmunoprecipitate")\n  (:form . "coimmunoprecipitated") (:end . 32) (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sos1") (:form . "Sos1") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sos2") (:form . "Sos2") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x557.6.1) (:span 49 52)))\n (:nscopes ((:id . :x557.6.1) (:span 49 95)))\n (:identifiers (:sid . :s557.6) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005157@unknown@formal@none@1@S@In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Grb2") (:form . "Grb2") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "coimmunoprecipitate")\n  (:form . "coimmunoprecipitated") (:end . 45) (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sos1") (:form . "Sos1") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Sos2") (:form . "Sos2") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x557.7.1) (:span 69 72)))\n (:nscopes ((:id . :x557.7.1) (:span 69 84)))\n (:identifiers (:sid . :s557.7) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005158@unknown@formal@none@1@S@Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 33) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "lat/pp36/38") (:form . "LAT/pp36/38") (:end . 45)\n  (:start . 34) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "detergent") (:form . "detergent") (:end . 58)\n  (:start . 49) (:id . 47))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 66)\n  (:start . 59) (:id . 48))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 75)\n  (:start . 67) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 89)\n  (:start . 81) (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 100)\n  (:start . 90) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 119)\n  (:start . 109) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 56))\n ((:tag . "NN") (:stem . "grb2") (:form . "Grb2") (:end . 129) (:start . 125)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 133) (:start . 130)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 142) (:start . 138)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x557.8.1) (:span 134 137)))\n (:nscopes ((:id . :x557.8.1) (:span 134 142)))\n (:identifiers (:sid . :s557.8) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005160@unknown@formal@none@1@S@A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GrpL-SLP-76") (:form . "GrpL-SLP-76") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GrpL") (:form . "GrpL") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 119)\n  (:start . 113) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x557.10.1) (:span 48 57)))\n (:hscopes ((:id . :x557.10.1) (:span 0 165)))\n (:identifiers (:sid . :s557.10) (:did . :|10209041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005161@unknown@formal@none@1@S@Unexpected and coordinated expression of Spi-1, Fli-1, and megakaryocytic genes in four Epo-dependent cell lines established from transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.@(((:tag . "VBN") (:stem . "unexpecte") (:form . "Unexpected") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Spi-1") (:form . "Spi-1") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Fli-1") (:form . "Fli-1") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 73) (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "epo-dependent") (:form . "Epo-dependent")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 145)\n  (:start . 141) (:id . 62))\n ((:tag . "VBG") (:stem . "display") (:form . "displaying") (:end . 156)\n  (:start . 146) (:id . 63))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 175) (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 186)\n  (:start . 176) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 191) (:start . 190)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "thermosensitive") (:form . "thermosensitive")\n  (:end . 207) (:start . 192) (:id . 68))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 212) (:start . 208)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 214) (:start . 213)\n  (:id . 70))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 222)\n  (:start . 215) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s558.1) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005162@unknown@formal@none@1@S@Most erythroleukemic cell lines established in vitro coexpress erythrocytic and megakaryocytic markers that often are associated with expression of Spi-1 and/or Fli-1 transcription factors known as transactivators of megakaryocyte-specific promoters.@(((:tag . "RBS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "erythroleukemic") (:form . "erythroleukemic")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "coexpres") (:form . "coexpress") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "erythrocytic") (:form . "erythrocytic") (:end . 75)\n  (:start . 63) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 94) (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 102)\n  (:start . 95) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 54))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 113)\n  (:start . 108) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 128)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "spi-1") (:form . "Spi-1") (:end . 153)\n  (:start . 148) (:id . 61))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 160)\n  (:start . 154) (:id . 62))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 166)\n  (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 180) (:start . 167) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 188)\n  (:start . 181) (:id . 65))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 194)\n  (:start . 189) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 197) (:start . 195)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 213) (:start . 198) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "megakaryocyte-specific")\n  (:form . "megakaryocyte-specific") (:end . 239) (:start . 217) (:id . 70))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 249)\n  (:start . 240) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s558.2) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005163@unknown@formal@none@1@S@In the present study, we examined the possibility of establishing new cell lines keeping strictly erythroid-specific properties in vitro through the targeted and conditional immortalization of erythrocytic progenitors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "establish") (:form . "establishing") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "keep") (:form . "keeping") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 116) (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "conditional") (:form . "conditional") (:end . 173)\n  (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 189) (:start . 174) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "erythrocytic") (:form . "erythrocytic") (:end . 205)\n  (:start . 193) (:id . 69))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 217)\n  (:start . 206) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s558.3) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005164@unknown@formal@none@1@S@For that purpose, we established several lines of transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 32)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "display") (:form . "displaying") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 95) (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "thermosensitive") (:form . "thermosensitive")\n  (:end . 127) (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 132) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 142)\n  (:start . 135) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s558.4) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005165@unknown@formal@none@1@S@As expected, these transgenic mice developed splenomegaly due to the massive amplification of Ter 119 positive erythroid nucleated cells expressing T antigen.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "splenomegaly") (:form . "splenomegaly") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "massive") (:form . "massive") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "amplification") (:form . "amplification")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ter") (:form . "Ter") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "CD") (:stem . "119") (:form . "119") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "nucleated") (:form . "nucleated") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 149) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s558.5) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005166@unknown@formal@none@1@S@Despite this drastic effect in vivo, the in vitro immortalization of erythropoietin-dependent erythroid progenitors unexpectedly occurred at low frequency, and all four cell lines established expressed both erythrocytic (globins) and megakaryocytic markers (glycoprotein IIb, platelet factor 4) as well as Spi-1 and Fli-1 transcripts at permissive temperature.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "drastic") (:form . "drastic") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 65) (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "erythropoietin-dependent")\n  (:form . "erythropoietin-dependent") (:end . 93) (:start . 69) (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 115)\n  (:start . 104) (:id . 56))\n ((:tag . "RB") (:stem . "unexpectedly") (:form . "unexpectedly") (:end . 128)\n  (:start . 116) (:id . 57))\n ((:tag . "VBD") (:stem . 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"(") (:end . 258) (:start . 257)\n  (:id . 78))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 270)\n  (:start . 258) (:id . 79))\n ((:tag . "NNP") (:stem . "IIb") (:form . "IIb") (:end . 274) (:start . 271)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 275) (:start . 274)\n  (:id . 81))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 284)\n  (:start . 276) (:id . 82))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 291)\n  (:start . 285) (:id . 83))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 293) (:start . 292)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 294) (:start . 293)\n  (:id . 85))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 297) (:start . 295)\n  (:id . 86))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 302) (:start . 298)\n  (:id . 87))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 305) (:start . 303)\n  (:id . 88))\n ((:tag . "NN") (:stem . "spi-1") (:form . "Spi-1") (:end . 311)\n  (:start . 306) (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 315) (:start . 312)\n  (:id . 90))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 321)\n  (:start . 316) (:id . 91))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 333)\n  (:start . 322) (:id . 92))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 336) (:start . 334)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 347)\n  (:start . 337) (:id . 94))\n ((:tag . "NN") (:stem . "temperature") (:form . "temperature") (:end . 359)\n  (:start . 348) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 360) (:start . 359)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s558.6) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005167@unknown@formal@none@1@S@Switching the cells to the nonpermissive temperature led to a marked increase in globin gene expression and concomitant decrease in expression of Spi-1, Fli-1, and megakaryocytic genes in an erythropoietin-dependent manner.@(((:tag . "VBG") (:stem . "switch") (:form . "Switching") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nonpermissive") (:form . "nonpermissive")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "temperature") (:form . "temperature") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Spi-1") (:form . "Spi-1") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Fli-1") (:form . "Fli-1") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 178) (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 184)\n  (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "erythropoietin-dependent")\n  (:form . "erythropoietin-dependent") (:end . 215) (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 222)\n  (:start . 216) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s558.7) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005168@unknown@formal@none@1@S@Interestingly, enhanced expression of Spi-1 and Fli-1 genes already was detected in the Ter 119 positive cell population of transgenic mice spleen in vivo.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "spi-1") (:form . "Spi-1") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ter") (:form . "Ter") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "CD") (:stem . "119") (:form . "119") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 139)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 154) (:start . 150)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s558.8) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005170@unknown@formal@none@1@S@Taken together, these data indicate that the unexpected expression of megakaryocytic genes is a specific property of immortalized cells that cannot be explained only by enhanced expression of Spi-1 and/or Fli-1 genes.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unexpected") (:form . "unexpected") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 84) (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "immortalize") (:form . "immortalized") (:end . 129)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 188)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "spi-1") (:form . "Spi-1") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 204)\n  (:start . 198) (:id . 72))\n ((:tag . "NN") (:stem . "fli-1") (:form . "Fli-1") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 216)\n  (:start . 211) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x558.10.2) (:span 27 40)))\n (:ncues ((:id . :x558.10.1) (:span 141 147)))\n (:hscopes ((:id . :x558.10.2) (:span 27 216)))\n (:nscopes ((:id . :x558.10.1) (:span 136 216)))\n (:identifiers (:sid . :s558.10) (:did . :|10210321|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005171@unknown@formal@none@1@S@LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent.@(((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-Induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 101)\n  (:start . 95) (:id . 54))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 111)\n  (:start . 102) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 144)\n  (:start . 133) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s559.1) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005172@unknown@formal@none@1@S@BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is an important mediator of septic shock.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "septic") (:form . "septic") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s559.2) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005173@unknown@formal@none@1@S@Endotoxin (LPS) signal transduction in human monocytes leads to activation of nuclear factor-kappa B (NF-kappaB) and TNF-alpha release.@(((:tag . "NNP") (:stem . "Endotoxin") (:form . "Endotoxin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s559.3) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005174@unknown@formal@none@1@S@Previous studies have implicated activation of both protein kinase C (PKC) and protein tyrosine kinases (PTK) in LPS-induced NF-kappaB activation and TNF-alpha production.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 124)\n  (:start . 113) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s559.4) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005175@unknown@formal@none@1@S@We hypothesized that inhibition of either PKC or PTK would decrease LPS-induced NF-kappaB DNA binding and TNF-alpha release in human monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x559.5.1) (:span 35 41 46 48))\n  ((:id . :x559.5.3) (:span 3 15)))\n (:hscopes ((:id . :x559.5.1) (:span 35 52))\n  ((:id . :x559.5.3) (:span 3 142)))\n (:identifiers (:sid . :s559.5) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005176@unknown@formal@none@1@S@MATERIALS AND METHODS: Human monocytes were stimulated with PMA (50 ng/ml) alone or LPS (100 ng/ml) with and without a nonspecific serine/threonine protein kinase inhibitor staurosporine (Stauro), a specific pan-PKC inhibitor bisindolylmaleimide (Bis), or an inhibitor of PTK genistein (Gen).@(((:tag . "NNP") (:stem . "MATERIALS") (:form . "MATERIALS") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "METHODS") (:form . "METHODS") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . 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5005177@unknown@formal@none@1@S@TNF-alpha release in culture supernatants was measured by an ELISA.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s559.7) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005178@unknown@formal@none@1@S@NF-kappaB DNA binding was evaluated by electrophoretic mobility shift assay.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 54) (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s559.8) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005180@unknown@formal@none@1@S@Nonspecific protein kinase inhibition inhibited NF-kappaB activation and TNF-alpha release, while specific PKC inhibition with Bis had no effect on LPS-induced NF-kappaB DNA binding or TNF-alpha release.@(((:tag . "JJ") (:stem . "nonspecific") (:form . "Nonspecific") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 82)\n  (:start . 73) (:id . 50))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 90)\n  (:start . 83) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 52))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 106)\n  (:start . 98) (:id . 54))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 121)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Bis") (:form . "Bis") (:end . 130) (:start . 127)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 144)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 159)\n  (:start . 148) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 169)\n  (:start . 160) (:id . 64))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 181)\n  (:start . 174) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 184) (:start . 182)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 194)\n  (:start . 185) (:id . 68))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 202)\n  (:start . 195) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x559.10.1) (:span 135 137)))\n (:nscopes ((:id . :x559.10.1) (:span 135 202)))\n (:identifiers (:sid . :s559.10) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005181@unknown@formal@none@1@S@PTK inhibition with Gen attenuated both LPS-induced NF-kappaB DNA binding and TNF-alpha production in human monocytes.@(((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Gen") (:form . "Gen") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s559.11) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005182@unknown@formal@none@1@S@Direct activation of PKC with PMA induced both NF-kappaB activation and TNF-alpha production by human monocytes.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s559.12) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005183@unknown@formal@none@1@S@CONCLUSIONS: These results suggest that LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes are independent of PKC activity.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "These") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 94)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 129)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x559.13.1) (:span 27 34)))\n (:hscopes ((:id . :x559.13.1) (:span 27 145)))\n (:identifiers (:sid . :s559.13) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005184@unknown@formal@none@1@S@Furthermore, our results provide evidence that PTK plays a role in LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 78)\n  (:start . 67) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 182)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 189)\n  (:start . 183) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 205)\n  (:start . 193) (:id . 72))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 212)\n  (:start . 206) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x559.14.1) (:span 161 170))\n  ((:id . :x559.14.2) (:span 150 155)))\n (:hscopes ((:id . :x559.14.1) (:span 161 212))\n  ((:id . :x559.14.2) (:span 150 212)))\n (:identifiers (:sid . :s559.14) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005185@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s559.15) (:did . :|10210645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005186@unknown@formal@none@1@S@Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "disposition") (:form . "disposition") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sulphamethoxazole") (:form . "sulphamethoxazole")\n  (:end . 41) (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 75)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 96) (:start . 80) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s560.1) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005187@unknown@formal@none@1@S@1. Bioactivation of sulphamethoxazole (SMX) to chemically-reactive metabolites and subsequent protein conjugation is thought to be involved in SMX hypersensitivity.@(((:tag . "LS") (:stem . "1.") (:form . "1.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bioactivation") (:form . "Bioactivation")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sulphamethoxazole") (:form . "sulphamethoxazole")\n  (:end . 37) (:start . 20) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chemically-reactive")\n  (:form . "chemically-reactive") (:end . 66) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "conjugation") (:form . "conjugation") (:end . 113)\n  (:start . 102) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 124)\n  (:start . 117) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 163) (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x560.2.1) (:span 117 124)))\n (:hscopes ((:id . :x560.2.1) (:span 83 163)))\n (:identifiers (:sid . :s560.2) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005188@unknown@formal@none@1@S@We have therefore examined the cellular metabolism, disposition and conjugation of SMX and its metabolites in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "disposition") (:form . "disposition") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "conjugation") (:form . "conjugation") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 106)\n  (:start . 95) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s560.3) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005190@unknown@formal@none@1@S@Cellular haptenation by SMX-NO was reduced by exogenous glutathione (GSH).@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "haptenation") (:form . "haptenation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SMX-NO") (:form . "SMX-NO") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 67)\n  (:start . 56) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s560.5) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005191@unknown@formal@none@1@S@3. SMX-NHOH and SMX-NO were rapidly reduced back to the parent compound by cysteine (CYS), GSH, human peripheral blood cells and plasma, suggesting that this is an important and ubiquitous bioinactivation mechanism.@(((:tag . "LS") (:stem . "3.") (:form . "3.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "SMX-NHOH") (:form . "SMX-NHOH") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SMX-NO") (:form . "SMX-NO") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "RB") (:stem . "back") (:form . "back") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "parent") (:form . "parent") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CYS") (:form . "CYS") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 112)\n  (:start . 102) (:id . 63))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 135)\n  (:start . 129) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 147)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 157) (:start . 153)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 160) (:start . 158)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 163) (:start . 161)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 173)\n  (:start . 164) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 188)\n  (:start . 178) (:id . 76))\n ((:tag . "NN") (:stem . "bioinactivation") (:form . "bioinactivation")\n  (:end . 204) (:start . 189) (:id . 77))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 214)\n  (:start . 205) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x560.6.1) (:span 137 147)))\n (:hscopes ((:id . :x560.6.1) (:span 137 214)))\n (:identifiers (:sid . :s560.6) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005192@unknown@formal@none@1@S@4. Fluorescence HPLC showed that SMX-NHOH and SMX-NO depleted CYS and GSH in buffer, and to a lesser extent, in cells and plasma.@(((:tag . "LS") (:stem . "4.") (:form . "4.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Fluorescence") (:form . "Fluorescence") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "HPLC") (:form . "HPLC") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 27) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SMX-NHOH") (:form . "SMX-NHOH") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SMX-NO") (:form . "SMX-NO") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "VBD") (:stem . "deplete") (:form . "depleted") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "cys") (:form . "CYS") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "buffer") (:form . "buffer") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 128)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s560.7) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005193@unknown@formal@none@1@S@5. Neutrophil apoptosis and inhibition of neutrophil function were induced at lower concentrations of SMX-NHOH and SMX-NO than those inducing loss of membrane viability, with SMX having no effect.@(((:tag . "LS") (:stem . "5.") (:form . "5.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Neutrophil") (:form . "Neutrophil") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 98) (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SMX-NHOH") (:form . "SMX-NHOH") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "SMX-NO") (:form . "SMX-NO") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 168)\n  (:start . 159) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 185)\n  (:start . 179) (:id . 69))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 188) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 195)\n  (:start . 189) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x560.8.1) (:span 186 188)))\n (:nscopes ((:id . :x560.8.1) (:span 186 195)))\n (:identifiers (:sid . :s560.8) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005194@unknown@formal@none@1@S@Lymphocytes were significantly (P<0.05) more sensitive to the direct cytotoxic effects of SMX-NO than neutrophils.@(((:tag . "NNP") (:stem . "Lymphocyte") (:form . "Lymphocytes") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "P<0.05") (:form . "P<0.05") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SMX-NO") (:form . "SMX-NO") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s560.9) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005195@unknown@formal@none@1@S@6. Partitioning of SMX-NHOH into red blood cells was significantly (P<0.05) lower than with the hydroxylamine of dapsone.@(((:tag . "LS") (:stem . "6.") (:form . "6.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "partitioning") (:form . "Partitioning") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SMX-NHOH") (:form . "SMX-NHOH") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 66) (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "P<0.05") (:form . "P<0.05") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hydroxylamine") (:form . "hydroxylamine")\n  (:end . 109) (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dapsone") (:form . "dapsone") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s560.10) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005196@unknown@formal@none@1@S@7. Our results suggest that the balance between oxidation of SMX to its toxic metabolites and their reduction is an important protective cellular mechanism.@(((:tag . "LS") (:stem . "7.") (:form . "7.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SMX") (:form . "SMX") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "toxic") (:form . "toxic") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 99)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 136)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x560.11.1) (:span 15 22)))\n (:hscopes ((:id . :x560.11.1) (:span 15 155)))\n (:identifiers (:sid . :s560.11) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005197@unknown@formal@none@1@S@If an imbalance exists, haptenation of the toxic metabolites to bodily proteins including the surface of viable cells can occur, and may result in drug hypersensitivity.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "imbalance") (:form . "imbalance") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "haptenation") (:form . "haptenation") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "toxic") (:form . "toxic") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "bodily") (:form . "bodily") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 168) (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x560.12.1) (:span 133 136))\n  ((:id . :x560.12.2) (:span 118 121)))\n (:hscopes ((:id . :x560.12.1) (:span 133 168))\n  ((:id . :x560.12.2) (:span 118 127)))\n (:identifiers (:sid . :s560.12) (:did . :|10217534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005198@unknown@formal@none@1@S@Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.@(((:tag . "JJ") (:stem . "tcf-1-mediated") (:form . "Tcf-1-mediated")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 59)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "glycogen") (:form . "glycogen") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "kinase-3") (:form . "kinase-3") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 110)\n  (:start . 99) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s561.1) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005200@unknown@formal@none@1@S@Recently, members of the Lef/Tcf transcription factor family have been identified as protein partners of beta-catenin, explaining how beta-catenin alters gene expression.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Lef/Tcf") (:form . "Lef/Tcf") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "explain") (:form . "explaining") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 146)\n  (:start . 134) (:id . 62))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s561.3) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005201@unknown@formal@none@1@S@Here we report that in T cells, Tcf-1 also becomes transcriptionally active through interaction with beta-catenin, suggesting that the Wnt signal transduction pathway is operational in T lymphocytes as well.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tcf-1") (:form . "Tcf-1") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 50)\n  (:start . 43) (:id . 52))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 68) (:start . 51) (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Wnt") (:form . "Wnt") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 158)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "operational") (:form . "operational") (:end . 181)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 198)\n  (:start . 187) (:id . 71))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 201) (:start . 199)\n  (:id . 72))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x561.4.1) (:span 115 125)))\n (:hscopes ((:id . :x561.4.1) (:span 115 206)))\n (:identifiers (:sid . :s561.4) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005202@unknown@formal@none@1@S@However, although Wnt signals are known to inhibit the activity of the negative regulatory protein kinase glycogen synthase kinase-3beta (GSK-3beta), resulting in increased levels of beta-catenin, we find no evidence for involvement of GSK-3beta in Tcf-mediated transcription in T cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "Wnt") (:form . "Wnt") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "glycogen") (:form . "glycogen") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "kinase-3beta") (:form . "kinase-3beta") (:end . 136)\n  (:start . 124) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GSK-3beta") (:form . "GSK-3beta") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 159)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 172)\n  (:start . 163) (:id . 68))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 179)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 195)\n  (:start . 183) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 199) (:start . 197)\n  (:id . 73))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 220) (:start . 217)\n  (:id . 77))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 232)\n  (:start . 221) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "GSK-3beta") (:form . "GSK-3beta") (:end . 245)\n  (:start . 236) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 248) (:start . 246)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "tcf-mediated") (:form . "Tcf-mediated") (:end . 261)\n  (:start . 249) (:id . 82))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 275) (:start . 262) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 278) (:start . 276)\n  (:id . 84))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 280) (:start . 279)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 286)\n  (:start . 281) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 287) (:start . 286)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x561.5.1) (:span 205 207)))\n (:nscopes ((:id . :x561.5.1) (:span 205 286)))\n (:identifiers (:sid . :s561.5) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005203@unknown@formal@none@1@S@That is, a dominant negative GSK-3beta does not specifically activate Tcf transcription and stimuli (lithium or phytohemagglutinin) that inhibit GSK-3beta activity also do not activate Tcf reporter genes.@(((:tag . "DT") (:stem . "that") (:form . "That") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 19)\n  (:start . 11) (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "gsk-3beta") (:form . "GSK-3beta") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 60)\n  (:start . 48) (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "Tcf") (:form . "Tcf") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lithium") (:form . "lithium") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 130) (:start . 112) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "GSK-3beta") (:form . "GSK-3beta") (:end . 154)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . "NNP") (:stem . "Tcf") (:form . "Tcf") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 197)\n  (:start . 189) (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 203)\n  (:start . 198) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x561.6.1) (:span 172 175)))\n (:nscopes ((:id . :x561.6.1) (:span 172 203)))\n (:identifiers (:sid . :s561.6) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005204@unknown@formal@none@1@S@Thus, inhibition of GSK-3beta is insufficient to activate Tcf-dependent transcription in T lymphocytes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GSK-3beta") (:form . "GSK-3beta") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "tcf-dependent") (:form . "Tcf-dependent")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s561.7) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005205@unknown@formal@none@1@S@In contrast, in C57MG fibroblast cells, lithium inactivates GSK-3beta and induces Tcf-controlled transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c57mg") (:form . "C57MG") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lithium") (:form . "lithium") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "VBZ") (:stem . "inactivate") (:form . "inactivates") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "GSK-3beta") (:form . "GSK-3beta") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "tcf-controlled") (:form . "Tcf-controlled")\n  (:end . 96) (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s561.8) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005206@unknown@formal@none@1@S@This is the first demonstration that lithium can alter gene expression of Tcf-responsive genes, and points to a difference in regulation of Wnt signaling between fibroblasts and lymphocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lithium") (:form . "lithium") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tcf-responsive") (:form . "Tcf-responsive")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "point") (:form . "points") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 136)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Wnt") (:form . "Wnt") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 173)\n  (:start . 162) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 189)\n  (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s561.9) (:did . :|10221643|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005207@unknown@formal@none@1@S@CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes.@(((:tag . "JJ") (:stem . "ciita-induced") (:form . "CIITA-induced")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "occupation") (:form . "occupation") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 98) (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promoter-bound") (:form . "promoter-bound")\n  (:end . 120) (:start . 106) (:id . 57))\n ((:tag . "JJ") (:stem . "multi-protein") (:form . "multi-protein")\n  (:end . 134) (:start . 121) (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 144)\n  (:start . 135) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s562.1) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005208@unknown@formal@none@1@S@Precise regulation of MHC class II expression plays a crucial role in the control of the immune response.@(((:tag . "JJ") (:stem . "precise") (:form . "Precise") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s562.2) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005210@unknown@formal@none@1@S@Activation of MHC class II promoters requires binding of at least three distinct multi-protein complexes (RFX, X2BP and NF-Y).@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "multi-protein") (:form . "multi-protein")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "X2BP") (:form . "X2BP") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s562.4) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005211@unknown@formal@none@1@S@It is known that the stability of this binding results from cooperative interactions between these proteins.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s562.5) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005212@unknown@formal@none@1@S@We show here that expression of CIITA in MHC class II- cells triggers occupation of the promoters by these complexes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ii-") (:form . "II-") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "occupation") (:form . "occupation") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s562.6) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005213@unknown@formal@none@1@S@This observation raised the possibility that the effect of CIITA on promoter occupation is mediated by an effect on the cooperative stabilization of the DNA-bound multi-protein complexes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "raise") (:form . "raised") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "occupation") (:form . "occupation") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 145) (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dna-bound") (:form . "DNA-bound") (:end . 162)\n  (:start . 153) (:id . 66))\n ((:tag . "JJ") (:stem . "multi-protein") (:form . "multi-protein")\n  (:end . 176) (:start . 163) (:id . 67))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 186)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x562.7.1) (:span 17 39)))\n (:hscopes ((:id . :x562.7.1) (:span 17 186)))\n (:identifiers (:sid . :s562.7) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005214@unknown@formal@none@1@S@We show, however, that the presence of CIITA does not affect the stability of the higher-order protein complex formed on DNA by RFX, X2BP and NF-Y.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 35)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 60)\n  (:start . 54) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 74)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "higher-ord") (:form . "higher-order") (:end . 94)\n  (:start . 82) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "X2BP") (:form . "X2BP") (:end . 137) (:start . 133)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 146) (:start . 142)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x562.8.1) (:span 50 53)))\n (:nscopes ((:id . :x562.8.1) (:span 50 146)))\n (:identifiers (:sid . :s562.8) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005215@unknown@formal@none@1@S@This suggests other mechanisms for CIITA-induced promoter occupancy, such as an effect on chromatin structure leading to increased accessibility of MHC class II promoters.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ciita-induced") (:form . "CIITA-induced")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "accessibility") (:form . "accessibility")\n  (:end . 144) (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 170)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x562.9.1) (:span 5 13)))\n (:hscopes ((:id . :x562.9.1) (:span 5 170)))\n (:identifiers (:sid . :s562.9) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005216@unknown@formal@none@1@S@This ability of CIITA to facilitate promoter occupation is undissociable from its transactivation potential.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "occupation") (:form . "occupation") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "undissociable") (:form . "undissociable")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 97) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s562.10) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005217@unknown@formal@none@1@S@Finally, we conclude that this effect of CIITA is cell-type specific, since expression of CIITA is not required for normal occupation of MHC class II promoters in B lymphocytes.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "occupation") (:form . "occupation") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 159)\n  (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 176)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x562.11.1) (:span 99 102)))\n (:nscopes ((:id . :x562.11.1) (:span 99 176)))\n (:identifiers (:sid . :s562.11) (:did . :|10221658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005218@unknown@formal@none@1@S@Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation.@(((:tag . "NNP") (:stem . "Immunosuppressant") (:form . "Immunosuppressant")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 23) (:start . 18)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "triptolide") (:form . "triptolide") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "purine-box/nuclear") (:form . "purine-box/nuclear")\n  (:end . 112) (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 132)\n  (:start . 123) (:id . 58))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 140)\n  (:start . 133) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 154)\n  (:start . 145) (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 170) (:start . 155) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 181)\n  (:start . 171) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s563.1) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005220@unknown@formal@none@1@S@PG490 inhibits interleukin(IL)-2 expression by normal human peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and antibody to CD3 (IC50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC50 of 40 ng/ml).@(((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "CD") (:stem . "interleukin(IL)-2") (:form . "interleukin(IL)-2")\n  (:end . 32) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 53)\n  (:start . 47) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 76) (:start . 71)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 88)\n  (:start . 77) (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 99)\n  (:start . 89) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 112)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 125)\n  (:start . 113) (:id . 55))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 136)\n  (:start . 126) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 141) (:start . 138)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 155)\n  (:start . 147) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IC50") (:form . "IC50") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Iono") (:form . "Iono") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "ic50") (:form . "IC50") (:end . 221) (:start . 217)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 80))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 227) (:start . 225)\n  (:id . 81))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 233)\n  (:start . 228) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s563.3) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005221@unknown@formal@none@1@S@In Jurkat T-cells, PG490 inhibits PMA/Iono-stimulated IL-2 transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "pma/iono-stimulated")\n  (:form . "PMA/Iono-stimulated") (:end . 53) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s563.4) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005222@unknown@formal@none@1@S@PG490 inhibits the induction of DNA binding activity at the purine-box/antigen receptor response element (ARRE)/nuclear factor of activated T-cells (NF-AT) target sequence but not at the NF-kappaB site.@(((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "purine-box/antigen") (:form . "purine-box/antigen")\n  (:end . 78) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ARRE)/nuclear") (:form . "ARRE)/nuclear")\n  (:end . 119) (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 147)\n  (:start . 140) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 162)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 196)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x563.5.1) (:span 176 179)))\n (:nscopes ((:id . :x563.5.1) (:span 176 201)))\n (:identifiers (:sid . :s563.5) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005223@unknown@formal@none@1@S@PG490 can completely inhibit transcriptional activation at the purine-box/ARRE/NF-AT and NF-kappaB target DNA sequences triggered by all stimuli examined (PMA, PMA/Iono, tumor necrosis factor-alpha).@(((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 44) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "purine-box/arre/nf-at")\n  (:form . "purine-box/ARRE/NF-AT") (:end . 84) (:start . 63) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 98)\n  (:start . 89) (:id . 52))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 105)\n  (:start . 99) (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 109) (:start . 106)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 119)\n  (:start . 110) (:id . 55))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 129)\n  (:start . 120) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 136) (:start . 133)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 144)\n  (:start . 137) (:id . 59))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 153)\n  (:start . 145) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA/Iono") (:form . "PMA/Iono") (:end . 168)\n  (:start . 160) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 175)\n  (:start . 170) (:id . 66))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 184)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 197)\n  (:start . 185) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 198) (:start . 197)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s563.6) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005224@unknown@formal@none@1@S@PG490 also inhibits PMA-stimulated activation of a chimeric transcription factor in which the C-terminal TA1 transactivation domain of NF-kappaB p65 is fused to the DNA binding domain of GAL4.@(((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "pma-stimulated") (:form . "PMA-stimulated")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "TA1") (:form . "TA1") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 124) (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 131)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 144)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 157)\n  (:start . 152) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 183)\n  (:start . 177) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s563.7) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005225@unknown@formal@none@1@S@In 16HBE human bronchial epithelial cells, IL-8 expression is regulated predominantly by NF-kappaB, and PG490 but not cyclosporin A can completely inhibit expression of IL-8.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "16hbe") (:form . "16HBE") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PG490") (:form . "PG490") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x563.8.1) (:span 114 117)))\n (:nscopes ((:id . :x563.8.1) (:span 114 131)))\n (:identifiers (:sid . :s563.8) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005226@unknown@formal@none@1@S@The mechanism of PG490 inhibition of cytokine gene expression differs from cyclosporin A and involves nuclear inhibition of transcriptional activation of NF-kappaB and the purine-box regulator operating at the ARRE/NF-AT site at a step after specific DNA binding.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pg490") (:form . "PG490") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 139) (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 150)\n  (:start . 140) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 163)\n  (:start . 154) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "purine-box") (:form . "purine-box") (:end . 182)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 192)\n  (:start . 183) (:id . 67))\n ((:tag . "VBG") (:stem . "operate") (:form . "operating") (:end . 202)\n  (:start . 193) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 205) (:start . 203)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "arre/nf-at") (:form . "ARRE/NF-AT") (:end . 220)\n  (:start . 210) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 225) (:start . 221)\n  (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 228) (:start . 226)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 230) (:start . 229)\n  (:id . 74))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 235) (:start . 231)\n  (:id . 75))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 241)\n  (:start . 236) (:id . 76))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 250)\n  (:start . 242) (:id . 77))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 254) (:start . 251)\n  (:id . 78))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 262)\n  (:start . 255) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s563.9) (:did . :|10224109|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005227@unknown@formal@none@1@S@Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 57) (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 72)\n  (:start . 61) (:id . 49))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 83)\n  (:start . 73) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 96)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 110)\n  (:start . 100) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 123)\n  (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 137) (:start . 124) (:id . 57))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 140) (:start . 138)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s564.1) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005228@unknown@formal@none@1@S@In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 32) (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "85-kda") (:form . "85-kDa") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 101) (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s564.2) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005230@unknown@formal@none@1@S@These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 147) (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 150) (:start . 148)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 160)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 173)\n  (:start . 161) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 190)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x564.4.1) (:span 98 108)))\n (:hscopes ((:id . :x564.4.1) (:span 98 190)))\n (:identifiers (:sid . :s564.4) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005231@unknown@formal@none@1@S@We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "trifluoromethylketone")\n  (:form . "trifluoromethylketone") (:end . 51) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 92) (:start . 90)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 103)\n  (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 121) (:start . 104) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 146)\n  (:start . 134) (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 151) (:start . 147)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 158)\n  (:start . 152) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 167)\n  (:start . 162) (:id . 61))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 197) (:start . 168)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 208)\n  (:start . 198) (:id . 63))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 214)\n  (:start . 209) (:id . 64))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 226)\n  (:start . 215) (:id . 65))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 237)\n  (:start . 227) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s564.5) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005232@unknown@formal@none@1@S@In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "trifluoromethylketone")\n  (:form . "trifluoromethylketones") (:end . 87) (:start . 65) (:id . 53))\n ((:tag . "VBP") (:stem . "interfere") (:form . "interfere") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s564.6) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005233@unknown@formal@none@1@S@We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 56) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inhibitor-kappab") (:form . "inhibitor-kappaB")\n  (:end . 134) (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 140)\n  (:start . 135) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s564.7) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005234@unknown@formal@none@1@S@Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 57) (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 98) (:start . 85) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s564.8) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005235@unknown@formal@none@1@S@Trifluoromethylketones ameliorate chronic inflammation in vivo.@(((:tag . "NNS") (:stem . "trifluoromethylketone")\n  (:form . "Trifluoromethylketones") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "ameliorate") (:form . "ameliorate") (:end . 33)\n  (:start . 23) (:id . 43))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 41)\n  (:start . 34) (:id . 44))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 54)\n  (:start . 42) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 62) (:start . 58)\n  (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s564.9) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005236@unknown@formal@none@1@S@Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 22)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "reside") (:form . "reside") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "retention") (:form . "retention") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "VBG") (:stem . "abrogate") (:form . "abrogating") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 140) (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 159) (:start . 146) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x564.10.1) (:span 31 34)))\n (:hscopes ((:id . :x564.10.1) (:span 31 159)))\n (:identifiers (:sid . :s564.10) (:did . :|10225377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005237@unknown@formal@none@1@S@Molecular regulation of cytokine gene expression during the immune response.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s565.1) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005238@unknown@formal@none@1@S@Cytokine expression by immune system cells plays an important role in the regulation of the immune response.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s565.2) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005240@unknown@formal@none@1@S@Two types of effector cells characterized by their distinct expression of cytokine profiles have been described.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 50)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s565.4) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005241@unknown@formal@none@1@S@Th1 cells produce IL-2 and IFN-gamma, whereas Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13.@(((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 98) (:start . 93)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s565.5) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005242@unknown@formal@none@1@S@In many pathological situations, the balance between Th1 and Th2 immune responses determines the outcome of diverse immunologically mediated clinical syndromes including infectious, autoimmune, and allergic diseases.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pathological") (:form . "pathological") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "situation") (:form . "situations") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "VBZ") (:stem . "determine") (:form . "determines") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "outcome") (:form . "outcome") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 131) (:start . 116) (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 159)\n  (:start . 150) (:id . 63))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 169)\n  (:start . 160) (:id . 64))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 180)\n  (:start . 170) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 192)\n  (:start . 182) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 206)\n  (:start . 198) (:id . 70))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 215)\n  (:start . 207) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s565.6) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005243@unknown@formal@none@1@S@However, the molecular basis for the tissue-specific expression of Th1/Th2-like cytokines has remained elusive.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 52) (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "th1/th2-like") (:form . "Th1/Th2-like") (:end . 79)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "remain") (:form . "remained") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "JJ") (:stem . "elusive") (:form . "elusive") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s565.7) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005244@unknown@formal@none@1@S@In this review we evaluate the possible in vivo role of different transcription factors and transcriptional mechanisms in T cell differentiation and the immune response.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "evaluate") (:form . "evaluate") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 107) (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 144) (:start . 129) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x565.8.1) (:span 31 39)))\n (:hscopes ((:id . :x565.8.1) (:span 31 168)))\n (:identifiers (:sid . :s565.8) (:did . :|10226884|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005245@unknown@formal@none@1@S@The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 129)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 164) (:start . 160)\n  (:id . 68))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 180)\n  (:start . 169) (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 191) (:start . 190)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "STAT-6") (:form . "STAT-6") (:end . 202)\n  (:start . 196) (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 210)\n  (:start . 203) (:id . 75))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 216)\n  (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s566.1) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005246@unknown@formal@none@1@S@Germline C gamma gene transcription is a crucial event in the process that leads to switch DNA recombination to IgG, but its regulation in the human is poorly understood.@(((:tag . "NNP") (:stem . "Germline") (:form . "Germline") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VB") (:stem . "switch") (:form . "switch") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 135)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 158)\n  (:start . 152) (:id . 70))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 169)\n  (:start . 159) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s566.2) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005247@unknown@formal@none@1@S@We took advantage of our monoclonal model of germinal center B cell differentiation, IgM+ IgD+ CL-01 cells, to define the role of the I gamma 3 evolutionarily conserved sequence (ECS) in the germline transcriptional activation of the human C gamma 3 gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "take") (:form . "took") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 83) (:start . 68) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "igm+") (:form . "IgM+") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "igd+") (:form . "IgD+") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cl-01") (:form . "CL-01") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 135) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 141)\n  (:start . 136) (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 143) (:start . 142)\n  (:id . 69))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 158) (:start . 144) (:id . 70))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 168)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 177)\n  (:start . 169) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "ECS") (:form . "ECS") (:end . 182) (:start . 179)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 77))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 199)\n  (:start . 191) (:id . 78))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 215) (:start . 200) (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 226)\n  (:start . 216) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 233) (:start . 230)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 239)\n  (:start . 234) (:id . 83))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 241) (:start . 240)\n  (:id . 84))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 247)\n  (:start . 242) (:id . 85))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 249) (:start . 248)\n  (:id . 86))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 254) (:start . 250)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s566.3) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005248@unknown@formal@none@1@S@The I gamma 3 ECS lies upstream of the major I gamma 3 transcription initiation site and displays more than 90% identity with the corresponding human I gamma 1, I gamma 2, and I gamma 4 regions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ecs") (:form . "ECS") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 52) (:start . 47)\n  (:id . 53))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 54) (:start . 53)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 55))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 120)\n  (:start . 112) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 143)\n  (:start . 130) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 157)\n  (:start . 152) (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 159) (:start . 158)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 72))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 162) (:start . 161)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 168)\n  (:start . 163) (:id . 74))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 170) (:start . 169)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 77))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 177) (:start . 176)\n  (:id . 78))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 183)\n  (:start . 178) (:id . 79))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 185) (:start . 184)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 193)\n  (:start . 186) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s566.4) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005250@unknown@formal@none@1@S@In these transfected CL-01 cells, CD40:CD40L engagement and exposure to IL-4 synergistically induced gamma 3 ECS-dependent luciferase reporter gene activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "cl-01") (:form . "CL-01") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD40:CD40L") (:form . "CD40:CD40L") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 92) (:start . 77) (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ecs-dependent") (:form . "ECS-dependent")\n  (:end . 122) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 133)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 142)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s566.6) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005251@unknown@formal@none@1@S@Targeted mutational analysis demonstrated that a tandem NF-kappa B/Rel binding motif is critical for the gamma 3 ECS responsiveness to both CD40L and IL-4, while a STAT-6-binding site is additionally required for IL-4 inducibility.@(((:tag . "VBN") (:stem . "target") (:form . "Targeted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mutational") (:form . "mutational") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ecs") (:form . "ECS") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 131) (:start . 117) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "stat-6-binding") (:form . "STAT-6-binding")\n  (:end . 178) (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "RB") (:stem . "additionally") (:form . "additionally") (:end . 199)\n  (:start . 187) (:id . 72))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 208)\n  (:start . 200) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 217) (:start . 213)\n  (:id . 75))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 230)\n  (:start . 218) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s566.7) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005252@unknown@formal@none@1@S@Electrophoretic mobility shift assays showed that p50/p65/c-Rel and STAT-6 are effectively induced by CD40L and IL-4, respectively, and bind to specific DNA motifs within the ECS.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 44) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p50/p65/c-rel") (:form . "p50/p65/c-Rel")\n  (:end . 63) (:start . 50) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT-6") (:form . "STAT-6") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 90)\n  (:start . 79) (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ecs") (:form . "ECS") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s566.8) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005253@unknown@formal@none@1@S@These partially overlapping CD40L and IL-4 responsive elements are functionally cooperative as the disruption of one of them prevents synergistic promoter activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "cd40l") (:form . "CD40L") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 79)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 109)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 145)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 154)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s566.9) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005254@unknown@formal@none@1@S@Thus, the gamma 3 ECS is an inducible promoter containing cis elements that critically mediate CD40L and IL-4-triggered transcriptional activation of the human C gamma 3 gene.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ecs") (:form . "ECS") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 37)\n  (:start . 28) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 46)\n  (:start . 38) (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 100)\n  (:start . 95) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "il-4-triggered") (:form . "IL-4-triggered")\n  (:end . 119) (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 135) (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s566.10) (:did . :|10228008|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005255@unknown@formal@none@1@S@Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.@(((:tag . "JJ") (:stem . "thrombin-induced") (:form . "Thrombin-induced")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 20) (:start . 17)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 112)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 123)\n  (:start . 113) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 147)\n  (:start . 139) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s567.1) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005256@unknown@formal@none@1@S@We investigated the mechanisms by which proinflammatory mediator, thrombin, released during intravascular coagulation and tissue injury, induces ICAM-1 (CD54) expression in endothelial cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 55) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "intravascular") (:form . "intravascular")\n  (:end . 105) (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "coagulation") (:form . "coagulation") (:end . 117)\n  (:start . 106) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 128)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 151)\n  (:start . 145) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd54") (:form . "CD54") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 184)\n  (:start . 173) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 190)\n  (:start . 185) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s567.2) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005257@unknown@formal@none@1@S@Stimulation of HUVEC with thrombin resulted in dose- and time-dependent increases in ICAM-1 mRNA and cell surface expression and in ICAM-1-dependent endothelial adhesivity toward polymorphonuclear leukocytes.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dose-") (:form . "dose-") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 71) (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "icam-1-dependent") (:form . "ICAM-1-dependent")\n  (:end . 148) (:start . 132) (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 160)\n  (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "adhesivity") (:form . "adhesivity") (:end . 171)\n  (:start . 161) (:id . 64))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 178)\n  (:start . 172) (:id . 65))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 196) (:start . 179) (:id . 66))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 207)\n  (:start . 197) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s567.3) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005258@unknown@formal@none@1@S@Transient transfection of endothelial cells with ICAM-1 promoter luciferase reporter gene (ICAM-1LUC) constructs indicated that deletion of upstream NF-kappa B site (-533 bases from translation start site) had no effect on thrombin responsiveness, whereas mutation/deletion of downstream NF-kappa B site (-223 bases from the translation start site) prevented the activation of ICAM-1 promoter, indicating that the downstream NF-kappa B site is critical for thrombin inducibility.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . 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(:end . 479) (:start . 478)\n  (:id . 115)))@@@1@74@((:hcues ((:id . :x567.4.1) (:span 394 409))\n  ((:id . :x567.4.3) (:span 113 127)))\n (:ncues ((:id . :x567.4.2) (:span 210 212)))\n (:hscopes ((:id . :x567.4.1) (:span 394 478))\n  ((:id . :x567.4.3) (:span 113 478)))\n (:nscopes ((:id . :x567.4.2) (:span 210 246)))\n (:identifiers (:sid . :s567.4) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005260@unknown@formal@none@1@S@Gel supershift assays demonstrated that thrombin induced binding of NF-kappa Bp65 (Rel A) to downstream NF-kappa B site of the ICAM-1 promoter.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NNP") (:stem . "Bp65") (:form . "Bp65") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 142)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s567.6) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005261@unknown@formal@none@1@S@Thrombin receptor activation peptide, a 14-amino-acid peptide representing the new NH2 terminus of proteolytically activated receptor-1, mimicked thrombin's action in inducing ICAM-1 expression.@(((:tag . "NNP") (:stem . "Thrombin") (:form . "Thrombin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "14-amino-acid") (:form . "14-amino-acid")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 74)\n  (:start . 62) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nh2") (:form . "NH2") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "RB") (:stem . "proteolytically") (:form . "proteolytically")\n  (:end . 114) (:start . 99) (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "receptor-1") (:form . "receptor-1") (:end . 135)\n  (:start . 125) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "mimic") (:form . "mimicked") (:end . 145)\n  (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 156) (:start . 154)\n  (:id . 62))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 163)\n  (:start . 157) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 175)\n  (:start . 167) (:id . 65))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 182)\n  (:start . 176) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 193)\n  (:start . 183) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s567.7) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005262@unknown@formal@none@1@S@These data indicate that thrombin activates endothelial ICAM-1 expression and polymorphonuclear leukocyte adhesion by NF-kappa Bp65 binding to the downstream NF-kappa B site of ICAM-1 promoter after proteolytically activated receptor-1 activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 95) (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 105)\n  (:start . 96) (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 114)\n  (:start . 106) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 126)\n  (:start . 118) (:id . 56))\n ((:tag . "NNP") (:stem . "Bp65") (:form . "Bp65") (:end . 131) (:start . 127)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 139)\n  (:start . 132) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 157)\n  (:start . 147) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 166)\n  (:start . 158) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 173) (:start . 169)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 65))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 183)\n  (:start . 177) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 192)\n  (:start . 184) (:id . 67))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 198)\n  (:start . 193) (:id . 68))\n ((:tag . "RB") (:stem . "proteolytically") (:form . "proteolytically")\n  (:end . 214) (:start . 199) (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 224)\n  (:start . 215) (:id . 70))\n ((:tag . "JJ") (:stem . "receptor-1") (:form . "receptor-1") (:end . 235)\n  (:start . 225) (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 246)\n  (:start . 236) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x567.8.1) (:span 11 24)))\n (:hscopes ((:id . :x567.8.1) (:span 11 246)))\n (:identifiers (:sid . :s567.8) (:did . :|10228026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005263@unknown@formal@none@1@S@Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apoptosis-linked") (:form . "apoptosis-linked")\n  (:end . 70) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s568.1) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005264@unknown@formal@none@1@S@Programmed cell death is a process required for the normal development of an organism.@(((:tag . "VBN") (:stem . "program") (:form . "Programmed") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s568.2) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005265@unknown@formal@none@1@S@One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Fas/Fas") (:form . "Fas/Fas") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s568.3) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005266@unknown@formal@none@1@S@During studies of apoptosis induced by T cell-receptor engagement, we identified ALG-4F, a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell-receptor") (:form . "cell-receptor")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "ALG-4F") (:form . "ALG-4F") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cell-receptor-induced")\n  (:form . "cell-receptor-induced") (:end . 149) (:start . 128) (:id . 62))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 167)\n  (:start . 155) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 182)\n  (:start . 177) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s568.4) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005267@unknown@formal@none@1@S@Overexpression of full-length ALG-4 induced transcription of FasL and, consequently, apoptosis.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "alg-4") (:form . "ALG-4") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "RB") (:stem . "consequently") (:form . "consequently") (:end . 83)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s568.5) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005268@unknown@formal@none@1@S@These results indicate that ALG-4 is necessary and sufficient for FasL expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alg-4") (:form . "ALG-4") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x568.6.1) (:span 14 27)))\n (:hscopes ((:id . :x568.6.1) (:span 14 81)))\n (:identifiers (:sid . :s568.6) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005270@unknown@formal@none@1@S@Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets.@(((:tag . "VBG") (:stem . "understand") (:form . "Understanding") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "elucidate") (:form . "elucidating") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 161)\n  (:start . 150) (:id . 63))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 169)\n  (:start . 162) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s568.8) (:did . :|10229231|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005271@unknown@formal@none@1@S@High molecular weight dextran sulfate increases the activity of NF-kappaB-regulated promoter in monocyte-derived macrophages.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "dextran") (:form . "dextran") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "sulfate") (:form . "sulfate") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nf-kappab-regulated")\n  (:form . "NF-kappaB-regulated") (:end . 83) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 112) (:start . 96) (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 124)\n  (:start . 113) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s569.1) (:did . :|10229275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005272@unknown@formal@none@1@S@It is known that sulfated polysaccharides can mimic the action of common T-cell mitogens.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sulfated") (:form . "sulfated") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "polysaccharide") (:form . "polysaccharides")\n  (:end . 41) (:start . 26) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s569.2) (:did . :|10229275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005273@unknown@formal@none@1@S@To investigate the molecular basis of the mitogenic effect of high molecular weight dextran sulfate (HMDS), monocyte-derived macrophages were transfected with recombinant plasmid containing chloramphenicol acetyl transferase (CAT) reporter gene under the control of the HIV-1 long terminal repeat (LTR) promoter, which is regulated by transcription factor NF-kappaB.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . 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5005274@unknown@formal@none@1@S@We observed that HMDS, similar to bacterial lipopolysaccharide (LPS), increases the expression of CAT reporter gene suggesting increased activity of NF-kappaB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HMDS") (:form . "HMDS") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 62) (:start . 44) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x569.4.1) (:span 116 126)))\n (:hscopes ((:id . :x569.4.1) (:span 116 158)))\n (:identifiers (:sid . :s569.4) (:did . :|10229275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005275@unknown@formal@none@1@S@The activation of NF-kappaB correlated with the increased expression of B7.1 molecules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s569.5) (:did . :|10229275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005276@unknown@formal@none@1@S@It was postulated that this NF-kappaB-regulated promoter might play a role in the activation of the accessory cells as well as the rate of replication of HIV-1 in monocyte-derived macrophages.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "postulate") (:form . "postulated") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nf-kappab-regulated")\n  (:form . "NF-kappaB-regulated") (:end . 47) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 150)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 179) (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x569.6.1) (:span 57 62)))\n (:hscopes ((:id . :x569.6.1) (:span 57 191)))\n (:identifiers (:sid . :s569.6) (:did . :|10229275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005277@unknown@formal@none@1@S@CTLA-4-Mediated inhibition of early events of T cell proliferation.@(((:tag . "JJ") (:stem . "ctla-4-mediated") (:form . "CTLA-4-Mediated")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 42)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s570.1) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005278@unknown@formal@none@1@S@CTLA-4 engagement by mAbs inhibits, while CD28 enhances, IL-2 production and proliferation upon T cell activation.@(((:tag . "NN") (:stem . "ctla-4") (:form . "CTLA-4") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "enhance") (:form . "enhances") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 90) (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s570.2) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005280@unknown@formal@none@1@S@CTLA-4 ligation inhibited CD3/CD28-induced IL-2 mRNA accumulation by inhibiting IL-2 transcription, which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei.@(((:tag . "NN") (:stem . "ctla-4") (:form . "CTLA-4") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "cd3/cd28-induced") (:form . "CD3/CD28-induced")\n  (:end . 42) (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 47) (:start . 43)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 65)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 79)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 113)\n  (:start . 106) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 128)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . "VBG") (:stem . "decrease") (:form . "decreasing") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 161)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 174)\n  (:start . 162) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 188)\n  (:start . 182) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x570.4.1) (:span 106 113)))\n (:hscopes ((:id . :x570.4.1) (:span 100 188)))\n (:identifiers (:sid . :s570.4) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005281@unknown@formal@none@1@S@However, CTLA-4 ligation did not appear to affect the CD28-mediated stabilization of IL-2 mRNA.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "ctla-4") (:form . "CTLA-4") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd28-mediated") (:form . "CD28-mediated")\n  (:end . 67) (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x570.5.2) (:span 33 39)))\n (:ncues ((:id . :x570.5.1) (:span 29 32)))\n (:hscopes ((:id . :x570.5.2) (:span 9 94)))\n (:nscopes ((:id . :x570.5.1) (:span 9 94)))\n (:identifiers (:sid . :s570.5) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005282@unknown@formal@none@1@S@Further, CTLA-4 engagement inhibited progression through the cell cycle by inhibiting the production of cyclin D3, cyclin-dependent kinase (cdk)4, and cdk6 when the T cells were stimulated with anti-CD3/CD28 and with anti-CD3 alone.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "ctla-4") (:form . "CTLA-4") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 131) (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "CD") (:stem . "cdk)4") (:form . "cdk)4") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cdk6") (:form . "cdk6") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 188)\n  (:start . 178) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "anti-cd3/cd28") (:form . "anti-CD3/CD28")\n  (:end . 207) (:start . 194) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 216) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 225)\n  (:start . 217) (:id . 77))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 231)\n  (:start . 226) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s570.6) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005283@unknown@formal@none@1@S@These results indicate that CTLA-4 signaling inhibits events early in T cell activation both at IL-2 transcription and at the level of IL-2-independent events of the cell cycle, and does not simply oppose CD28-mediated costimulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ctla-4") (:form . "CTLA-4") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "il-2-independent") (:form . "IL-2-independent")\n  (:end . 151) (:start . 135) (:id . 64))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 186) (:start . 182)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 197)\n  (:start . 191) (:id . 74))\n ((:tag . "VB") (:stem . "oppose") (:form . "oppose") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . "JJ") (:stem . "cd28-mediated") (:form . "CD28-mediated")\n  (:end . 218) (:start . 205) (:id . 76))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 232) (:start . 219) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x570.7.2) (:span 14 27)))\n (:ncues ((:id . :x570.7.1) (:span 187 190)))\n (:hscopes ((:id . :x570.7.2) (:span 14 232)))\n (:nscopes ((:id . :x570.7.1) (:span 187 232)))\n (:identifiers (:sid . :s570.7) (:did . :|10229815|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005284@unknown@formal@none@1@S@Fibroblast growth factor-1 (FGF-1) enhances IL-2 production and nuclear translocation of NF-kappaB in FGF receptor-bearing Jurkat T cells.@(((:tag . "NNP") (:stem . "Fibroblast") (:form . "Fibroblast") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fgf-1") (:form . "FGF-1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FGF") (:form . "FGF") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "receptor-bearing") (:form . "receptor-bearing")\n  (:end . 122) (:start . 106) (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s571.1) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005285@unknown@formal@none@1@S@Fibroblast growth factors (FGFs) are heparin-binding proteins crucial to embryogenesis, angiogenesis, and wound healing.@(((:tag . "NNP") (:stem . "Fibroblast") (:form . "Fibroblast") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNPS") (:stem . "FGF") (:form . "FGFs") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "heparin-binding") (:form . "heparin-binding")\n  (:end . 52) (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "embryogenesis") (:form . "embryogenesis")\n  (:end . 86) (:start . 73) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "angiogenesis") (:form . "angiogenesis") (:end . 100)\n  (:start . 88) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "wound") (:form . "wound") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "healing") (:form . "healing") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s571.2) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005286@unknown@formal@none@1@S@FGF-1 is abundantly expressed in the synovium in rheumatoid arthritis and in rejecting allografts, sites of chronic immune-mediated inflammation.@(((:tag . "NNP") (:stem . "FGF-1") (:form . "FGF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synovium") (:form . "synovium") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "reject") (:form . "rejecting") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "allograft") (:form . "allografts") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "immune-mediated") (:form . "immune-mediated")\n  (:end . 131) (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 144)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s571.3) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005287@unknown@formal@none@1@S@The frequency of FGF-1-responsive T cells is increased in the peripheral blood of these disorders, and a high percentage of infiltrating T cells in rheumatoid arthritis synovium express receptors for FGF-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fgf-1-responsive") (:form . "FGF-1-responsive")\n  (:end . 33) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "infiltrate") (:form . "infiltrating") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 158)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 168)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "synovium") (:form . "synovium") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 195)\n  (:start . 186) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "fgf-1") (:form . "FGF-1") (:end . 205)\n  (:start . 200) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s571.4) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005288@unknown@formal@none@1@S@To understand the action of FGF-1 in T cells, studies were initiated in Jurkat T cells that express the signaling isoform of FGF receptor-1.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fgf-1") (:form . "FGF-1") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 99)\n  (:start . 92) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 113)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 121)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "FGF") (:form . "FGF") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor-1") (:form . "receptor-1") (:end . 139)\n  (:start . 129) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s571.5) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005290@unknown@formal@none@1@S@Analogous to costimulation via CD28, this activity is mediated through activation of Rel/kappaB, a family of transcription factors known to regulate IL-2 and other activation-inducible proteins.@(((:tag . "JJ") (:stem . "analogous") (:form . "Analogous") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Rel/kappaB") (:form . "Rel/kappaB") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "JJ") (:stem . "activation-inducible")\n  (:form . "activation-inducible") (:end . 184) (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 193)\n  (:start . 185) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s571.7) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005291@unknown@formal@none@1@S@FGF-1 alone induces modest nuclear translocation of kappaB-binding proteins, and this translocation is enhanced by the combination of anti-CD3 and FGF-1.@(((:tag . "NNP") (:stem . "FGF-1") (:form . "FGF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "modest") (:form . "modest") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "kappab-binding") (:form . "kappaB-binding")\n  (:end . 66) (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 99) (:start . 86) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "FGF-1") (:form . "FGF-1") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s571.8) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005292@unknown@formal@none@1@S@This NF-kappaB binding complex is composed of transcriptionally active p65(RelA)/p50 heterodimers and results primarily from the targeted degradation of IkappaB-alpha, an inhibitor that sequesters Rel/kappaB in the cytoplasm.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 63) (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "CD") (:stem . "p65(RelA)/p50") (:form . "p65(RelA)/p50")\n  (:end . 84) (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 97)\n  (:start . 85) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 109)\n  (:start . 102) (:id . 54))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 119)\n  (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 124) (:start . 120)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 137)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 149)\n  (:start . 138) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 166) (:start . 153) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 170) (:start . 168)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 180)\n  (:start . 171) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "sequester") (:form . "sequesters") (:end . 196)\n  (:start . 186) (:id . 66))\n ((:tag . "NNP") (:stem . "Rel/kappaB") (:form . "Rel/kappaB") (:end . 207)\n  (:start . 197) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 224)\n  (:start . 215) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s571.9) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005293@unknown@formal@none@1@S@These data are the first to show a connection between FGF-1 signaling and NF-kappaB activation outside of embryonic development.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "connection") (:form . "connection") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "fgf-1") (:form . "FGF-1") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "outside") (:form . "outside") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 127)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s571.10) (:did . :|10229820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005294@unknown@formal@none@1@S@The signaling events that link FGF receptor-1 engagement and NF-kappaB activation in Jurkat are probably distinct from the CD28 costimulation pathway, since FGF-1-induced Rel/kappaB binding proteins do not contain significant levels of c-Rel and are not identical with the CD28 response complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "link") (:form . "link") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fgf") (:form . "FGF") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor-1") (:form . 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5005295@unknown@formal@none@1@S@Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha.@(((:tag . "VBG") (:stem . "signal") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymphotoxin-beta") (:form . "lymphotoxin-beta")\n  (:end . 38) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 58)\n  (:start . 48) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 64) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 76)\n  (:start . 65) (:id . 49))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 82) (:start . 77)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 101)\n  (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 114)\n  (:start . 107) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "membrane-bound") (:form . "membrane-bound")\n  (:end . 132) (:start . 118) (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 142)\n  (:start . 133) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s572.1) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005296@unknown@formal@none@1@S@The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ongoing") (:form . "ongoing") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "individual") (:form . "individual") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 93)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s572.2) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005297@unknown@formal@none@1@S@Among host immune factors, the cytokine TNF-alpha has previously been shown to increase HIV-1 replication in various monocyte and T cell model systems.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s572.3) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005298@unknown@formal@none@1@S@Here, we demonstrate that signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR), also regulates HIV-1 replication.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lymphotoxin-beta") (:form . "lymphotoxin-beta")\n  (:end . 96) (:start . 80) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LT-beta") (:form . "LT-beta") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LT-betaR") (:form . "LT-betaR") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 160)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s572.4) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005300@unknown@formal@none@1@S@Moreover, in a physiological coculture cellular assay system, we show that membrane-bound TNF-alpha and LT-alpha1beta2 act virtually identically to their soluble forms in the regulation of HIV-1 replication.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 28) (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "coculture") (:form . "coculture") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "membrane-bound") (:form . "membrane-bound")\n  (:end . 89) (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lt-alpha1beta2") (:form . "LT-alpha1beta2")\n  (:end . 118) (:start . 104) (:id . 58))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "RB") (:stem . "identically") (:form . "identically") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 167)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 185)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 206)\n  (:start . 195) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s572.6) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005301@unknown@formal@none@1@S@Thus, cosignaling via the LT-beta and TNF-alpha receptors is probably involved in the modulation of HIV-1 replication and the subsequent determination of HIV-1 viral burden in monocytes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "cosignale") (:form . "cosignaling") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LT-beta") (:form . "LT-beta") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 150) (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "burden") (:form . "burden") (:end . 172)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 185)\n  (:start . 176) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x572.7.1) (:span 61 69)))\n (:hscopes ((:id . :x572.7.1) (:span 6 185)))\n (:identifiers (:sid . :s572.7) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005302@unknown@formal@none@1@S@Intriguingly, surface expression of LT-alpha1beta2 is up-regulated on a T cell line acutely infected with HIV-1, suggesting a positive feedback loop between HIV-1 infection, LT-alpha1beta2 expression, and HIV-1 replication.@(((:tag . "RB") (:stem . "intriguingly") (:form . "Intriguingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lt-alpha1beta2") (:form . "LT-alpha1beta2")\n  (:end . 50) (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 66)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "RB") (:stem . "acutely") (:form . "acutely") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "feedback") (:form . "feedback") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lt-alpha1beta2") (:form . "LT-alpha1beta2")\n  (:end . 188) (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 222)\n  (:start . 211) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x572.8.1) (:span 113 123)))\n (:hscopes ((:id . :x572.8.1) (:span 113 222)))\n (:identifiers (:sid . :s572.8) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005303@unknown@formal@none@1@S@Given the critical role that LT-alpha1beta2 plays in lymphoid architecture, we speculate that LT-alpha1beta2 may be involved in HIV-associated abnormalities of the lymphoid organs.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lt-alpha1beta2") (:form . "LT-alpha1beta2")\n  (:end . 43) (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "architecture") (:form . "architecture") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "speculate") (:form . "speculate") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lt-alpha1beta2") (:form . "LT-alpha1beta2")\n  (:end . 108) (:start . 94) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "hiv-associated") (:form . "HIV-associated")\n  (:end . 142) (:start . 128) (:id . 61))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities")\n  (:end . 156) (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 172)\n  (:start . 164) (:id . 65))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 179)\n  (:start . 173) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x572.9.1) (:span 109 112))\n  ((:id . :x572.9.2) (:span 79 88)))\n (:hscopes ((:id . :x572.9.1) (:span 109 179))\n  ((:id . :x572.9.2) (:span 79 179)))\n (:identifiers (:sid . :s572.9) (:did . :|10229841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005304@unknown@formal@none@1@S@Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.@(((:tag . "NN") (:stem . "resistance") (:form . "Resistance") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "metastatic") (:form . "metastatic") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s573.1) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005305@unknown@formal@none@1@S@TNF is one of the cytokines secreted by the cells of the immune system.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 70)\n  (:start . 64) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s573.2) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005306@unknown@formal@none@1@S@Our data demonstrate that those cell lines lacking capability to form metastatic tumors in vivo are susceptible to TNF induced apoptosis in vitro.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "capability") (:form . "capability") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "metastatic") (:form . "metastatic") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x573.3.1) (:span 43 50)))\n (:nscopes ((:id . :x573.3.1) (:span 43 95)))\n (:identifiers (:sid . :s573.3) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005307@unknown@formal@none@1@S@However, cell lines with high metastatic potential are resistant to TNF in vitro.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "metastatic") (:form . "metastatic") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s573.4) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005308@unknown@formal@none@1@S@Furthermore, the same cell lines were resistant to cytolytic action of other cytotoxic proteins secreted by LAK cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cytolytic") (:form . "cytolytic") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s573.5) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005310@unknown@formal@none@1@S@This finding may provide a tool to improve current protocols of immunotherapy and insights to how tumor cells are or are not killed by LAK cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "VB") (:stem . "improve") (:form . "improve") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "protocol") (:form . "protocols") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunotherapy") (:form . "immunotherapy")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "kill") (:form . "killed") (:end . 131)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x573.7.2) (:span 114 116))\n  ((:id . :x573.7.3) (:span 13 16)))\n (:ncues ((:id . :x573.7.1) (:span 121 124)))\n (:hscopes ((:id . :x573.7.2) (:span 110 144))\n  ((:id . :x573.7.3) (:span 13 144)))\n (:nscopes ((:id . :x573.7.1) (:span 117 144)))\n (:identifiers (:sid . :s573.7) (:did . :|10232385|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005311@unknown@formal@none@1@S@NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 62) (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s574.1) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005312@unknown@formal@none@1@S@C5a, a potent peptide chemoattractant, stimulates interleukin-8 (IL-8) secretion from peripheral blood mononuclear cells (PBMC).@(((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 13) (:start . 7)\n  (:id . 45))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 37) (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s574.2) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005313@unknown@formal@none@1@S@Experiments were conducted to understand the mechanisms for C5a-induced IL-8 production, which was 14-fold greater than that in unstimulated cells by 2 hours.@(((:tag . "NNS") (:stem . "experiment") (:form . "Experiments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "RB") (:stem . "14-fold") (:form . "14-fold") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 140)\n  (:start . 128) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s574.3) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005314@unknown@formal@none@1@S@IL-8 secretion was accompanied by accumulation of IL-8 mRNA in the cytosol and by nuclear expression of a kappaB DNA binding activity within 30 minutes.@(((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s574.4) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005315@unknown@formal@none@1@S@AP-1 but not NF-IL-6 DNA binding activity was also detected in C5a-stimulated PBMC; however, its delayed expression (maximal at 4 hours) suggested a less important role in the rapid production of IL-8.@(((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-IL-6") (:form . "NF-IL-6") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "c5a-stimulated") (:form . "C5a-stimulated")\n  (:end . 77) (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 146)\n  (:start . 137) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 163)\n  (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 181)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 192)\n  (:start . 182) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 200) (:start . 196)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x574.5.1) (:span 137 146)))\n (:ncues ((:id . :x574.5.2) (:span 9 12)))\n (:hscopes ((:id . :x574.5.1) (:span 137 200)))\n (:nscopes ((:id . :x574.5.2) (:span 9 41)))\n (:identifiers (:sid . :s574.5) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005316@unknown@formal@none@1@S@The correlation between C5a-induced kappaB binding activity and IL-8 gene expression was examined in the RAW264.7 macrophage cells using reporter genes directed by the kappaB sequence from IkappaBalpha and IL-8 promoter regions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 42)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "raw264.7") (:form . "RAW264.7") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 136) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 160)\n  (:start . 152) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 174)\n  (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 201) (:start . 189) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 210) (:start . 206)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 219)\n  (:start . 211) (:id . 72))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 227)\n  (:start . 220) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s574.6) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005317@unknown@formal@none@1@S@C5a-induced reporter gene expression was abolished by introducing mutations into the kappaB sites and by coexpression of a dominant negative IkappaBalpha construct resistant to agonist-induced phosphorylation.@(((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "introduce") (:form . "introducing") (:end . 65)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 80) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 117)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 153) (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 163)\n  (:start . 154) (:id . 63))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 173)\n  (:start . 164) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "agonist-induced") (:form . "agonist-induced")\n  (:end . 192) (:start . 177) (:id . 66))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 208) (:start . 193) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s574.7) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005318@unknown@formal@none@1@S@Pertussis toxin, which ADP-ribosylates the Gi proteins known to couple to the C5a receptor, produced minimal inhibition of C5a-induced IL-8 expression and had little effect on C5a-induced calcium mobilization in RAW264.7 cells.@(((:tag . "NN") (:stem . "pertussis") (:form . "Pertussis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "adp-ribosylate") (:form . "ADP-ribosylates")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Gi") (:form . "Gi") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "couple") (:form . "couple") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 134)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 165)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 172)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "c5a-induced") (:form . "C5a-induced") (:end . 187)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 195)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 208)\n  (:start . 196) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 73))\n ((:tag . "NN") (:stem . "raw264.7") (:form . "RAW264.7") (:end . 220)\n  (:start . 212) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s574.8) (:did . :|10233875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005320@unknown@formal@none@1@S@Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "targeting") (:form . "targeting") (:end . 25)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "erythroblastic") (:form . "erythroblastic")\n  (:end . 69) (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 77)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 91)\n  (:start . 81) (:id . 52))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 105) (:start . 92) (:id . 53))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 110) (:start . 106)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s575.1) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005321@unknown@formal@none@1@S@Targeted expression to specific tissues or cell lineages is a necessary feature of a gene therapy vector for many clinical applications, such as correction of hemoglobinopathies or thalassemias by transplantation of genetically modified hematopoietic stem cells.@(((:tag . "VBN") (:stem . "target") (:form . "Targeted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "application") (:form . "applications") (:end . 135)\n  (:start . 123) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 155)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "hemoglobinopathy") (:form . "hemoglobinopathies")\n  (:end . 177) (:start . 159) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "thalassemia") (:form . "thalassemias") (:end . 193)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 212) (:start . 197) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 73))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 227)\n  (:start . 216) (:id . 74))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 236)\n  (:start . 228) (:id . 75))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 250) (:start . 237) (:id . 76))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 255) (:start . 251)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 261)\n  (:start . 256) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s575.2) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005322@unknown@formal@none@1@S@We developed retroviral vectors in which the constitutive viral enhancer in the U3 region of the 3' LTR is replaced by an autoregulatory enhancer of the erythroid-specific GATA-1 transcription factor gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 136) (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 171) (:start . 153) (:id . 69))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 192) (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 199)\n  (:start . 193) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 204) (:start . 200)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s575.3) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005323@unknown@formal@none@1@S@The replaced enhancer is propagated to the 5' LTR upon integration into the target cell genome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "propagate") (:form . "propagated") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s575.4) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005324@unknown@formal@none@1@S@The modified vectors were used to transduce human hematopoietic cell lines, cord blood-derived CD34(+) stem/progenitor cells, and murine bone marrow repopulating stem cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "blood-derived") (:form . "blood-derived")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "stem/progenitor") (:form . "stem/progenitor")\n  (:end . 118) (:start . 103) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "VBG") (:stem . "repopulate") (:form . "repopulating") (:end . 161)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 166) (:start . 162)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s575.5) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005325@unknown@formal@none@1@S@The expression of appropriate reporter genes (triangle upLNGFR, EGFP) was analyzed in the differentiated progeny of transduced stem cells in vitro, in liquid culture as well as in clonogenic assay, and in vivo, after bone marrow transplantation in lethally irradiated mice.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . 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5005326@unknown@formal@none@1@S@The GATA-1 autoregulatory enhancer effectively restricts the expression of the LTR-driven proviral transcription unit to the erythroblastic progeny of both human progenitors and mouse-repopulating stem cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "VBZ") (:stem . "restrict") (:form . "restricts") (:end . 56)\n  (:start . 47) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ltr-driven") (:form . "LTR-driven") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 54))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 117) (:start . 113)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "erythroblastic") (:form . "erythroblastic")\n  (:end . 139) (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 147)\n  (:start . 140) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 155) (:start . 151)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 161)\n  (:start . 156) (:id . 62))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 173)\n  (:start . 162) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mouse-repopulating") (:form . "mouse-repopulating")\n  (:end . 196) (:start . 178) (:id . 65))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 201) (:start . 197)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 207)\n  (:start . 202) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s575.7) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005327@unknown@formal@none@1@S@Packaging of viral particles, integration into the target genome, and stability of the integrated provirus are not affected by the LTR modification.@(((:tag . "NN") (:stem . "packaging") (:form . "Packaging") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "particle") (:form . "particles") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 147)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x575.8.1) (:span 111 114)))\n (:nscopes ((:id . :x575.8.1) (:span 0 147)))\n (:identifiers (:sid . :s575.8) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005328@unknown@formal@none@1@S@Enhancer replacement is therefore an effective strategy to target expression of a retroviral transgene to a specific progeny of transduced hematopoietic stem cells.@(((:tag . "NNP") (:stem . "Enhancer") (:form . "Enhancer") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VB") (:stem . "target") (:form . "target") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 152) (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 163)\n  (:start . 158) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s575.9) (:did . :|10233879|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005330@unknown@formal@none@1@S@The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 118) (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 138) (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 148)\n  (:start . 143) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "RB") (:stem . "alternatively") (:form . "alternatively")\n  (:end . 172) (:start . 159) (:id . 67))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 182)\n  (:start . 173) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "protect") (:form . "protecting") (:end . 197)\n  (:start . 187) (:id . 70))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 205)\n  (:start . 198) (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 215)\n  (:start . 206) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 220) (:start . 219)\n  (:id . 74))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 228)\n  (:start . 221) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 236) (:start . 232)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 242)\n  (:start . 237) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s576.2) (:did . :|10233882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005331@unknown@formal@none@1@S@However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x576.3.1) (:span 69 72)))\n (:nscopes ((:id . :x576.3.1) (:span 9 87)))\n (:identifiers (:sid . :s576.3) (:did . :|10233882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005332@unknown@formal@none@1@S@We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 151)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 189)\n  (:start . 180) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "FW") (:stem . "eg") (:form . "eg") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 200)\n  (:start . 195) (:id . 74))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 216)\n  (:start . 210) (:id . 76))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 222)\n  (:start . 217) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 78))\n ((:tag . "NN") (:stem . "interleukin-3") (:form . "interleukin-3")\n  (:end . 237) (:start . 224) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 265) (:start . 243) (:id . 82))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 284) (:start . 266) (:id . 83))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 291)\n  (:start . 285) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s576.4) (:did . :|10233882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005333@unknown@formal@none@1@S@In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "clonogenic") (:form . "clonogenic") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x576.5.1) (:span 43 46)))\n (:hscopes ((:id . :x576.5.1) (:span 33 126)))\n (:identifiers (:sid . :s576.5) (:did . :|10233882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005334@unknown@formal@none@1@S@These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "offer") (:form . "offer") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 184)\n  (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 195)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 208)\n  (:start . 199) (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 219)\n  (:start . 209) (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 222) (:start . 220)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 225) (:start . 223)\n  (:id . 74))\n ((:tag . "NN") (:stem . "adjunct") (:form . "adjunct") (:end . 233)\n  (:start . 226) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 236) (:start . 234)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 243)\n  (:start . 237) (:id . 77))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 256)\n  (:start . 244) (:id . 78))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 263)\n  (:start . 257) (:id . 79))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 266) (:start . 264)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "approach") (:form . "approached") (:end . 277)\n  (:start . 267) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 282) (:start . 278)\n  (:id . 82))\n ((:tag . "NN") (:stem . "caution") (:form . "caution") (:end . 290)\n  (:start . 283) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 291) (:start . 290)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x576.6.1) (:span 257 263))\n  ((:id . :x576.6.2) (:span 142 149)))\n (:hscopes ((:id . :x576.6.1) (:span 155 290))\n  ((:id . :x576.6.2) (:span 142 290)))\n (:identifiers (:sid . :s576.6) (:did . :|10233882|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005335@unknown@formal@none@1@S@Unicellular-unilineage erythropoietic cultures: molecular analysis of regulatory gene expression at sibling cell level.@(((:tag . "JJ") (:stem . "unicellular-unilineage")\n  (:form . "Unicellular-unilineage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "erythropoietic") (:form . "erythropoietic")\n  (:end . 37) (:start . 23) (:id . 43))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 46)\n  (:start . 38) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 47) (:start . 46)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 57)\n  (:start . 48) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 66)\n  (:start . 58) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 80)\n  (:start . 70) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 99) (:start . 97)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sibling") (:form . "sibling") (:end . 107)\n  (:start . 100) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 118)\n  (:start . 113) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s577.1) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005336@unknown@formal@none@1@S@In vitro studies on hematopoietic control mechanisms have been hampered by the heterogeneity of the analyzed cell populations, ie, lack of lineage specificity and developmental stage homogeneity of progenitor/precursor cells growing in culture.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "hamper") (:form . "hampered") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "heterogeneity") (:form . "heterogeneity")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "FW") (:stem . "ie") (:form . "ie") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 176) (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "NN") (:stem . "homogeneity") (:form . "homogeneity") (:end . 194)\n  (:start . 183) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "progenitor/precursor")\n  (:form . "progenitor/precursor") (:end . 218) (:start . 198) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 224)\n  (:start . 219) (:id . 73))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 232)\n  (:start . 225) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 75))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 243)\n  (:start . 236) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x577.2.1) (:span 131 135)))\n (:nscopes ((:id . :x577.2.1) (:span 131 243)))\n (:identifiers (:sid . :s577.2) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005337@unknown@formal@none@1@S@We developed unicellular culture systems for unilineage differentiation of purified hematopoietic progenitor cells followed by daughter cell analysis at cellular and molecular level.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "unicellular") (:form . "unicellular") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unilineage") (:form . "unilineage") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 71) (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 97) (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 108)\n  (:start . 98) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 54))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 123)\n  (:start . 115) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 56))\n ((:tag . "NN") (:stem . "daughter") (:form . "daughter") (:end . 135)\n  (:start . 127) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 58))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 149)\n  (:start . 141) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 152) (:start . 150)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 161)\n  (:start . 153) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 175)\n  (:start . 166) (:id . 63))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 181)\n  (:start . 176) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s577.3) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005338@unknown@formal@none@1@S@In the culture system reported here, (1) the growth factor (GF) stimulus induces cord blood (CB) progenitor cells to proliferate and differentiate/mature exclusively along the erythroid lineage; (2) this erythropoietic wave is characterized by less than 4% apoptotic cells; (3) asymmetric divisions are virtually absent, ie, nonresponsive hematopoietic progenitors with no erythropoietic potential are forced into apoptosis; (4) the system is cell division controlled (cdc), ie, the number of divisions performed by each cell is monitored.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "report") (:form . 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"is") (:end . 528) (:start . 526)\n  (:id . 139))\n ((:tag . "VBN") (:stem . "monitor") (:form . "monitored") (:end . 538)\n  (:start . 529) (:id . 140))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 539) (:start . 538)\n  (:id . 141)))@@@1@100@((:ncues ((:id . :x577.4.1) (:span 370 372))\n  ((:id . :x577.4.2) (:span 313 319)))\n (:nscopes ((:id . :x577.4.1) (:span 370 397))\n  ((:id . :x577.4.2) (:span 278 319)))\n (:identifiers (:sid . :s577.4) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005340@unknown@formal@none@1@S@Freshly isolated CD34(+) cells expressed CD34, c-kit, PU.1, and GATA-2 but did not express CD36, erythropoietin receptor (EpoR), SCL/Tal1, EKLF, NF-E2, GATA-1, or glyocophorin A (GPA).@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-kit") (:form . "c-kit") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 111) (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "EpoR") (:form . "EpoR") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "SCL/Tal1") (:form . "SCL/Tal1") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 143) (:start . 139)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-E2") (:form . "NF-E2") (:end . 150)\n  (:start . 145) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 158)\n  (:start . 152) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 162) (:start . 160)\n  (:id . 75))\n ((:tag . "NN") (:stem . "glyocophorin") (:form . "glyocophorin") (:end . 175)\n  (:start . 163) (:id . 76))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 177) (:start . 176)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "GPA") (:form . "GPA") (:end . 182) (:start . 179)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x577.6.1) (:span 79 82)))\n (:nscopes ((:id . :x577.6.1) (:span 79 183)))\n (:identifiers (:sid . :s577.6) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005341@unknown@formal@none@1@S@In early to intermediate stages of erythroid differentiation we monitored the induction of CD36, Tal1, EKLF, NF-E2, and GATA-1 that preceeded expression of EpoR.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "intermediate") (:form . "intermediate") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "monitor") (:form . "monitored") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Tal1") (:form . "Tal1") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-E2") (:form . "NF-E2") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "preceede") (:form . "preceeded") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EpoR") (:form . "EpoR") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s577.7) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005342@unknown@formal@none@1@S@In late stages of erythroid maturation, GPA was upregulated, whereas CD34, c-kit, PU.1, and GATA-2 were barely or not detected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GPA") (:form . "GPA") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-kit") (:form . "c-kit") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 98)\n  (:start . 92) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . "RB") (:stem . "barely") (:form . "barely") (:end . 110)\n  (:start . 104) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 126)\n  (:start . 118) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x577.8.1) (:span 114 117)))\n (:nscopes ((:id . :x577.8.1) (:span 114 126)))\n (:identifiers (:sid . :s577.8) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005343@unknown@formal@none@1@S@In addition, competitive single-cell RT-PCR was used to assay CD34 mRNA transcripts in sibling CD34(+) CD38(-) cells differentiating in unilineage erythroid cultures: this analysis allowed us to semiquantitate the gradual downmodulation of CD34 mRNA from progenitor cells through their differentiating erythroid progeny.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "single-cell") (:form . "single-cell") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "rt-pcr") (:form . "RT-PCR") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "assay") (:form . "assay") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sibling") (:form . "sibling") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "CD34(+)") (:form . "CD34(+)") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "JJ") (:stem . "CD38(-)") (:form . "CD38(-)") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 132) (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unilineage") (:form . "unilineage") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 156)\n  (:start . 147) (:id . 63))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 180)\n  (:start . 172) (:id . 67))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "VB") (:stem . "semiquantitate") (:form . "semiquantitate")\n  (:end . 209) (:start . 195) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "gradual") (:form . "gradual") (:end . 221)\n  (:start . 214) (:id . 73))\n ((:tag . "NN") (:stem . "downmodulation") (:form . "downmodulation")\n  (:end . 236) (:start . 222) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "CD34") (:form . "CD34") (:end . 244) (:start . 240)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 249) (:start . 245)\n  (:id . 77))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 254) (:start . 250)\n  (:id . 78))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 265)\n  (:start . 255) (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 271)\n  (:start . 266) (:id . 80))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 279)\n  (:start . 272) (:id . 81))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 285)\n  (:start . 280) (:id . 82))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 301) (:start . 286) (:id . 83))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 311)\n  (:start . 302) (:id . 84))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 319)\n  (:start . 312) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 320) (:start . 319)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s577.9) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005344@unknown@formal@none@1@S@It is concluded that this novel culture system, coupled with single-cell RT-PCR analysis, may eliminate the ambiguities intrinsic to molecular studies on heterogeneous populations of hematopoietic progenitors/precursors growing in culture, particularly in the initial stages of development.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "single-cell") (:form . "single-cell") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "VB") (:stem . "eliminate") (:form . "eliminate") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "ambiguity") (:form . "ambiguities") (:end . 119)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 167) (:start . 154) (:id . 66))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 179)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 196) (:start . 183) (:id . 69))\n ((:tag . "NNS") (:stem . "progenitors/precursor")\n  (:form . "progenitors/precursors") (:end . 219) (:start . 197) (:id . 70))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 227)\n  (:start . 220) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 72))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 238)\n  (:start . 231) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 74))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 252)\n  (:start . 240) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 255) (:start . 253)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 259) (:start . 256)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 267)\n  (:start . 260) (:id . 78))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 274)\n  (:start . 268) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 277) (:start . 275)\n  (:id . 80))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 289)\n  (:start . 278) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x577.10.1) (:span 90 93)))\n (:hscopes ((:id . :x577.10.1) (:span 90 289)))\n (:identifiers (:sid . :s577.10) (:did . :|10233888|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005345@unknown@formal@none@1@S@Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.@(((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s578.1) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005346@unknown@formal@none@1@S@Infection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and cell growth.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s578.2) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005347@unknown@formal@none@1@S@To interpret the mechanisms by which EBV activates the cell, we have assayed many proteins involved in control of the G0 and G1 phases of the cell cycle and regulation of apoptosis.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "interpret") (:form . "interpret") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "g0") (:form . "G0") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 134)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 152)\n  (:start . 147) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 71))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 167)\n  (:start . 157) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 73))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 180)\n  (:start . 171) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s578.3) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005348@unknown@formal@none@1@S@In EBV infection most of the changes, including the early induction of cyclin D2, are dependent on expression of EBV genes, but an alteration in the E2F-4 profile was partly independent of viral gene expression, presumably occurring in response to signal transduction activated when the virus binds to its receptor, CD21.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "change") (:form . 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(:end . 321) (:start . 320)\n  (:id . 98)))@@@1@57@((:hcues ((:id . :x578.4.1) (:span 212 222)))\n (:hscopes ((:id . :x578.4.1) (:span 212 320)))\n (:identifiers (:sid . :s578.4) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005350@unknown@formal@none@1@S@A20 can be regulated by the NF-kappaB transcription factor, which is known to be activated by the EBV LMP-1 protein.@(((:tag . "NNP") (:stem . "A20") (:form . "A20") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s578.6) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005351@unknown@formal@none@1@S@Quantitative assays demonstrated a direct temporal relationship between LMP-1 protein levels and active NF-kappaB during the time course of infection.@(((:tag . "JJ") (:stem . "quantitative") (:form . "Quantitative") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 19)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 63)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 71)\n  (:start . 64) (:id . 49))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 77) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 85)\n  (:start . 78) (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 92)\n  (:start . 86) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 103)\n  (:start . 97) (:id . 54))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 120)\n  (:start . 114) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 136)\n  (:start . 130) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 149)\n  (:start . 140) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s578.7) (:did . :|10233927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005352@unknown@formal@none@1@S@Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.@(((:tag . "NNP") (:stem . "Immortalization") (:form . "Immortalization")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "CD8(+)") (:form . "CD8(+)") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s579.1) (:did . :|10233947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005353@unknown@formal@none@1@S@The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax has been demonstrated to have transforming activity in multiple cell culture and transgenic-mouse models.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 63) (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 79) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 105)\n  (:start . 93) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 126)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transgenic-mouse") (:form . "transgenic-mouse")\n  (:end . 181) (:start . 165) (:id . 67))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 188)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s579.2) (:did . :|10233947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005354@unknown@formal@none@1@S@In addition to activating transcription from the viral long terminal repeat (LTR) through the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors, Tax activates the expression of multiple cellular promoters through the NF-kappaB pathway of transcriptional activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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5005355@unknown@formal@none@1@S@The Tax mutants M22 and M47 have previously been demonstrated to selectively abrogate the ability of Tax to activate transcription through the NF-kappaB or CREB/ATF pathway, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "M22") (:form . "M22") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M47") (:form . "M47") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "VB") (:stem . "abrogate") (:form . "abrogate") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 172)\n  (:start . 165) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 186)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s579.4) (:did . :|10233947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005356@unknown@formal@none@1@S@These mutations were introduced in the tax gene of the ACH functional molecular clone of HTLV-1, and virus produced from the mutant ACH clones was examined for the ability to replicate and immortalize primary human lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ACH") (:form . "ACH") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 131)\n  (:start . 125) (:id . 64))\n ((:tag . "NNP") (:stem . "ACH") (:form . "ACH") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 142)\n  (:start . 136) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 171)\n  (:start . 164) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 184)\n  (:start . 175) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "VB") (:stem . "immortalize") (:form . "immortalize") (:end . 200)\n  (:start . 189) (:id . 75))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 208)\n  (:start . 201) (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 214)\n  (:start . 209) (:id . 77))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 226)\n  (:start . 215) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s579.5) (:did . :|10233947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005357@unknown@formal@none@1@S@While virus derived from the clone containing the M47 mutation retained the ability to immortalize T lymphocytes, the M22 mutant lost the ability to immortalize infected cells.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "M47") (:form . "M47") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBD") (:stem . "retain") (:form . "retained") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VB") (:stem . "immortalize") (:form . "immortalize") (:end . 98)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "m22") (:form . "M22") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "VBD") (:stem . "lose") (:form . "lost") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 145)\n  (:start . 138) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "VB") (:stem . "immortalize") (:form . "immortalize") (:end . 160)\n  (:start . 149) (:id . 67))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s579.6) (:did . :|10233947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005358@unknown@formal@none@1@S@These results indicate that activation of the CREB/ATF pathway by Tax is dispensable for the immortalization of T cells by HTLV-1, whereas activation of the NF-kappaB pathway may be critical.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dispensable") (:form . "dispensable") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 108) (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 174)\n  (:start . 167) (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x579.7.1) (:span 175 178))\n  ((:id . :x579.7.2) (:span 14 27)))\n (:hscopes ((:id . :x579.7.1) (:span 175 190))\n  ((:id . :x579.7.2) (:span 14 190)))\n (:identifiers (:sid . :s579.7) (:did . :|10233947|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005360@unknown@formal@none@1@S@HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "infect") (:form . "infects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNPS") (:stem . "PBMC") (:form . "PBMCs") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s580.2) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005361@unknown@formal@none@1@S@We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gp120-anti-gp120") (:form . "gp120-anti-gp120")\n  (:end . 83) (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "heat-inactivated") (:form . "heat-inactivated")\n  (:end . 120) (:start . 104) (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ihiv-1") (:form . "iHIV-1") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 149)\n  (:start . 139) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 171)\n  (:start . 161) (:id . 66))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 179)\n  (:start . 172) (:id . 67))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 209)\n  (:start . 197) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 72))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s580.3) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005362@unknown@formal@none@1@S@In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 66) (:start . 53) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ihiv-1") (:form . "iHIV-1") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 155) (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 199)\n  (:start . 192) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s580.4) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005363@unknown@formal@none@1@S@Moreover, we further investigated the physiologic relevance of these observations.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 81)\n  (:start . 69) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s580.5) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005364@unknown@formal@none@1@S@When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "submit") (:form . "submitted") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ihiv-1") (:form . "iHIV-1") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "pbmc") (:form . "PBMCs") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 84) (:start . 70) (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s580.6) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005365@unknown@formal@none@1@S@This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 85) (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pbmc") (:form . "PBMCs") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s580.7) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005366@unknown@formal@none@1@S@Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies).@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "pbmc") (:form . "PBMCs") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cdr2-loop") (:form . "CDR2-loop") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "d1") (:form . "D1") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "CD4") (:form . "CD4") (:end . 167) (:start . 164)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 73))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 174)\n  (:start . 169) (:id . 74))\n ((:tag . "NN") (:stem . "envelope") (:form . "envelope") (:end . 183)\n  (:start . 175) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "anti-cd4") (:form . "anti-CD4") (:end . 196)\n  (:start . 188) (:id . 77))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 207)\n  (:start . 197) (:id . 78))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 218)\n  (:start . 208) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s580.8) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005367@unknown@formal@none@1@S@In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oligomerization") (:form . "oligomerization")\n  (:end . 78) (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D1") (:form . "D1") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "d1/cdr3-loop") (:form . "D1/CDR3-loop") (:end . 151)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x580.9.1) (:span 36 39)))\n (:nscopes ((:id . :x580.9.1) (:span 13 151)))\n (:identifiers (:sid . :s580.9) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005368@unknown@formal@none@1@S@Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "scd4") (:form . "sCD4") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 37)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 56)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "D1/CDR2-loop") (:form . "D1/CDR2-loop") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s580.10) (:did . :|10235509|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005370@unknown@formal@none@1@S@Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.@(((:tag . "VBG") (:stem . "define") (:form . "Defining") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "destructive") (:form . "destructive") (:end . 111)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 122)\n  (:start . 112) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 136)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "synovium") (:form . "synovium") (:end . 145)\n  (:start . 137) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 149) (:start . 146)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "spar") (:form . "spares") (:end . 156)\n  (:start . 150) (:id . 61))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 174) (:start . 157) (:id . 62))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 184)\n  (:start . 175) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s581.1) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005371@unknown@formal@none@1@S@The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "subject") (:form . "subject") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "controversy") (:form . "controversy") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s581.2) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005372@unknown@formal@none@1@S@We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adenoviral") (:form . "adenoviral") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 76) (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 115) (:start . 103) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "diseased") (:form . "diseased") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 190)\n  (:start . 184) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 196) (:start . 192)\n  (:id . 73))\n ((:tag . "CD") (:stem . ">90") (:form . ">90") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 201) (:start . 200)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 217)\n  (:start . 209) (:id . 78))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 229)\n  (:start . 218) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 242)\n  (:start . 231) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 243) (:start . 242)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 83))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 249) (:start . 248)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 255)\n  (:start . 250) (:id . 85))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 264)\n  (:start . 256) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s581.3) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005373@unknown@formal@none@1@S@We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "spontaneous") (:form . "spontaneous") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 98) (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 131) (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 145)\n  (:start . 135) (:id . 60))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 161)\n  (:start . 155) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 186) (:start . 182)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 204) (:start . 187) (:id . 69))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 214)\n  (:start . 205) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 71))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 220) (:start . 216)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 226)\n  (:start . 221) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 74))\n ((:tag . "NN") (:stem . "-11") (:form . "-11") (:end . 234) (:start . 231)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 243) (:start . 240)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 248) (:start . 244)\n  (:id . 79))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 257)\n  (:start . 249) (:id . 80))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 268)\n  (:start . 258) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s581.4) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005374@unknown@formal@none@1@S@Of even more interest, IkappaBalpha overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 50) (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "metalloproteinas") (:form . "metalloproteinases")\n  (:end . 104) (:start . 86) (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 106) (:start . 105)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 138)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 155)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x581.5.1) (:span 119 122)))\n (:nscopes ((:id . :x581.5.1) (:span 119 155)))\n (:identifiers (:sid . :s581.5) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005375@unknown@formal@none@1@S@Blocking NF-kappaB in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction.@(((:tag . "VBG") (:stem . "block") (:form . "Blocking") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "joint") (:form . "joint") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "destruction") (:form . "destruction") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s581.6) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005376@unknown@formal@none@1@S@The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adenoviral") (:form . "adenoviral") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "widespread") (:form . "widespread") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "applicability") (:form . "applicability")\n  (:end . 68) (:start . 55) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 143)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 150)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 160)\n  (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 169)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 188) (:start . 186)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "diseased") (:form . "diseased") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 211)\n  (:start . 205) (:id . 73))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 218)\n  (:start . 212) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s581.7) (:did . :|10318942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005377@unknown@formal@none@1@S@Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "growth-regulated") (:form . "growth-regulated")\n  (:end . 21) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "mcm5") (:form . "MCM5") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mcm6") (:form . "MCM6") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s582.1) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005378@unknown@formal@none@1@S@Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle.@(((:tag . "NN") (:stem . "initiation") (:form . "Initiation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MCM") (:form . "MCM") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "ensure") (:form . "ensuring") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 124)\n  (:start . 113) (:id . 60))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "RB") (:stem . "once") (:form . "once") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s582.2) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005380@unknown@formal@none@1@S@In this study, we examined the transcriptional activities of isolated human MCM gene promoters.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 46) (:start . 31) (:id . 49))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MCM") (:form . "MCM") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s582.4) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005381@unknown@formal@none@1@S@Human MCM5 and MCM6 promoters with mutation in the E2F sites failed in promoter regulation following serum stimulation and exogenous E2F expression.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MCM5") (:form . "MCM5") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MCM6") (:form . "MCM6") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 67) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x582.5.1) (:span 61 67)))\n (:nscopes ((:id . :x582.5.1) (:span 61 147)))\n (:identifiers (:sid . :s582.5) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005382@unknown@formal@none@1@S@In addition, we identified a novel E2F-like sequence in human MCM6 promoter which cooperates with the authentic E2F sites in E2F-dependent regulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "e2f-like") (:form . "E2F-like") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mcm6") (:form . "MCM6") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "authentic") (:form . "authentic") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "e2f-dependent") (:form . "E2F-dependent")\n  (:end . 138) (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s582.6) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005383@unknown@formal@none@1@S@Forced expression of E2F1 could induce expression of all members of the endogenous MCM genes in rat embryonal fibroblast REF52 cells.@(((:tag . "VBN") (:stem . "force") (:form . "Forced") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "E2F1") (:form . "E2F1") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "mcm") (:form . "MCM") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "embryonal") (:form . "embryonal") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "ref52") (:form . "REF52") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s582.7) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005384@unknown@formal@none@1@S@Our results demonstrated that the growth-regulated expression of mammalian MCM5 and MCM6 genes, and presumably other MCM members, is primarily regulated by E2F through binding to multiple E2F sites in the promoters.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "growth-regulated") (:form . "growth-regulated")\n  (:end . 50) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "mcm5") (:form . "MCM5") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mcm6") (:form . "MCM6") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "MCM") (:form . "MCM") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 175)\n  (:start . 168) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 214)\n  (:start . 205) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x582.8.1) (:span 100 110)))\n (:hscopes ((:id . :x582.8.1) (:span 100 128)))\n (:identifiers (:sid . :s582.8) (:did . :|10327050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005385@unknown@formal@none@1@S@Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.@(((:tag . "JJ") (:stem . "non-steroidal") (:form . "Non-steroidal")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 31) (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 37) (:start . 32)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 45)\n  (:start . 38) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 73)\n  (:start . 64) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 84)\n  (:start . 78) (:id . 51))\n ((:tag . "NN") (:stem . "hsp70") (:form . "HSP70") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s583.1) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005386@unknown@formal@none@1@S@Recent studies have shown that the non-steroidal anti-inflammatory drugs (NSAIDs) activate heat shock transcription factor (HSF1) from a latent cytoplasmic form to a nuclear, DNA binding state.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "non-steroidal") (:form . "non-steroidal")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 66) (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "NSAID") (:form . "NSAIDs") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HSF1") (:form . "HSF1") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 155)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 186)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 192)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s583.2) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005387@unknown@formal@none@1@S@As HSF1 can function as both an activator of heat shock genes and a repressor of non-heat shock genes such as IL1B and c- fos, we have examined the potential role of HSF1 in the effects of NSAIDs on gene expression in a human monocytic cell line THP-1.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HSF1") (:form . "HSF1") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activator") (:form . 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5005388@unknown@formal@none@1@S@We found that two members of the NSAIDs, sodium salicylate and sulindac repress the IL1B promoter to similar degree to heat shock or HSF1 overexpression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NSAID") (:form . "NSAIDs") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 47)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sulindac") (:form . "sulindac") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "VBP") (:stem . "repress") (:form . "repress") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il1b") (:form . "IL1B") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "hsf1") (:form . "HSF1") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 152) (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s583.4) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005390@unknown@formal@none@1@S@At least in the case of the IL1B promoter, repression did not seem to involve another factor whose activity is affected by the NSAIDs, NFkappaB as the IL1B promoter fragment used in our studies is not NFkappaB responsive and binds specifically to HSF1.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL1B") (:form . "IL1B") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 41)\n  (:start . 33) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 53)\n  (:start . 43) (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "VB") (:stem . "seem") (:form . "seem") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 77)\n  (:start . 70) (:id . 57))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 85)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NSAID") (:form . "NSAIDs") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 143)\n  (:start . 135) (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . 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(:end . 252) (:start . 251)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x583.6.3) (:span 62 66)))\n (:ncues ((:id . :x583.6.1) (:span 197 200))\n  ((:id . :x583.6.2) (:span 58 61)))\n (:hscopes ((:id . :x583.6.3) (:span 43 133)))\n (:nscopes ((:id . :x583.6.1) (:span 197 220))\n  ((:id . :x583.6.2) (:span 43 133)))\n (:identifiers (:sid . :s583.6) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005391@unknown@formal@none@1@S@Exposure to NSAIDs had a complex effect on HSP gene expression and while sulindac activated the stress responsive HSP70B promoter, sodium salicylate did not.@(((:tag . "NN") (:stem . "exposure") (:form . "Exposure") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NSAID") (:form . "NSAIDs") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HSP") (:form . "HSP") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sulindac") (:form . "sulindac") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "NNP") (:stem . "HSP70B") (:form . "HSP70B") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x583.7.1) (:span 153 156)))\n (:nscopes ((:id . :x583.7.1) (:span 153 156)))\n (:identifiers (:sid . :s583.7) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005392@unknown@formal@none@1@S@In addition, only a subset of the NSAIDs induced HSP70 mRNA species.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NNPS") (:stem . "NSAID") (:form . "NSAIDs") (:end . 40)\n  (:start . 34) (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "NNP") (:stem . "HSP70") (:form . "HSP70") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s583.8) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005393@unknown@formal@none@1@S@These findings reflect the properties of HSF1 which can be activated to at least two DNA binding forms only one of which activates heat shock promoters and suggest that individual NSAID family members may differentially induce one or other of these forms.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "reflect") (:form . "reflect") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hsf1") (:form . "HSF1") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 130)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 151)\n  (:start . 142) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 163)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 179)\n  (:start . 169) (:id . 71))\n ((:tag . "NN") (:stem . "nsaid") (:form . "NSAID") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 192)\n  (:start . 186) (:id . 73))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 200)\n  (:start . 193) (:id . 74))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 219) (:start . 205) (:id . 76))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 226)\n  (:start . 220) (:id . 77))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 230) (:start . 227)\n  (:id . 78))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 233) (:start . 231)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 239)\n  (:start . 234) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 242) (:start . 240)\n  (:id . 81))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 248)\n  (:start . 243) (:id . 82))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 254)\n  (:start . 249) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x583.9.1) (:span 231 233))\n  ((:id . :x583.9.2) (:span 201 204)) ((:id . :x583.9.3) (:span 156 163)))\n (:hscopes ((:id . :x583.9.1) (:span 227 239))\n  ((:id . :x583.9.2) (:span 201 254)) ((:id . :x583.9.3) (:span 156 254)))\n (:identifiers (:sid . :s583.9) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005394@unknown@formal@none@1@S@Overall therefore, exposure to NSAIDs leads to a profound switch in gene expression in monocytic cells, with suppression of genes involved in macrophage activation and induction of stress genes and HSF1 appears to play a regulatory role in these effects.@(((:tag . "RB") (:stem . "overall") (:form . "Overall") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NSAID") (:form . "NSAIDs") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 177)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 193)\n  (:start . 188) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "NN") (:stem . "hsf1") (:form . "HSF1") (:end . 202) (:start . 198)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 210)\n  (:start . 203) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 213) (:start . 211)\n  (:id . 76))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 218) (:start . 214)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 220) (:start . 219)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 231)\n  (:start . 221) (:id . 79))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 236) (:start . 232)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 239) (:start . 237)\n  (:id . 81))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 245)\n  (:start . 240) (:id . 82))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 253)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x583.10.1) (:span 203 210)))\n (:hscopes ((:id . :x583.10.1) (:span 198 253)))\n (:identifiers (:sid . :s583.10) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005395@unknown@formal@none@1@S@Copyright 1999 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s583.11) (:did . :|10328874|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005396@unknown@formal@none@1@S@Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.@(((:tag . "NN") (:stem . "disruption") (:form . "Disruption") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 84) (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 108) (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "id3") (:form . "Id3") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "commit") (:form . "committed") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 152)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x584.1.1) (:span 29 32)))\n (:nscopes ((:id . :x584.1.1) (:span 29 47)))\n (:identifiers (:sid . :s584.1) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005397@unknown@formal@none@1@S@Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC).@(((:tag . "VBN") (:stem . "enforce") (:form . "Enforced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Id3") (:form . "Id3") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . 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"(") (:end . 353) (:start . 352)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "FTOC") (:form . "FTOC") (:end . 357) (:start . 353)\n  (:id . 100))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 358) (:start . 357)\n  (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 359) (:start . 358)\n  (:id . 102)))@@@1@61@((:ncues ((:id . :x584.2.1) (:span 178 181)))\n (:nscopes ((:id . :x584.2.1) (:span 178 233)))\n (:identifiers (:sid . :s584.2) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005398@unknown@formal@none@1@S@Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "document") (:form . "document") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 36) (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Id3") (:form . "Id3") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 103) (:start . 89) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pre-t") (:form . "pre-T") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 139)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TCRalpha") (:form . "TCRalpha") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TCRgamma") (:form . "TCRgamma") (:end . 180)\n  (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x584.3.1) (:span 163 166)))\n (:nscopes ((:id . :x584.3.1) (:span 163 194)))\n (:identifiers (:sid . :s584.3) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005400@unknown@formal@none@1@S@These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "id3") (:form . "Id3") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 74) (:start . 60) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 93) (:start . 79) (:id . 52))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 100)\n  (:start . 94) (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 112)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pre-t") (:form . "pre-T") (:end . 121)\n  (:start . 116) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 132) (:start . 128)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TCRalpha") (:form . "TCRalpha") (:end . 141)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 146) (:start . 142)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 156)\n  (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 162)\n  (:start . 157) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x584.5.1) (:span 27 35)) ((:id . :x584.5.2) (:span 19 26)))\n (:hscopes ((:id . :x584.5.1) (:span 27 168))\n  ((:id . :x584.5.2) (:span 19 168)))\n (:identifiers (:sid . :s584.5) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005401@unknown@formal@none@1@S@We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "CD4(-)CD8(-)CD3(-)") (:form . "CD4(-)CD8(-)CD3(-)")\n  (:end . 53) (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "rearrange") (:form . "rearranged") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "id3-transduced") (:form . "Id3-transduced")\n  (:end . 115) (:start . 101) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "control-transduced") (:form . "control-transduced")\n  (:end . 147) (:start . 129) (:id . 60))\n ((:tag . "JJ") (:stem . "pre-t") (:form . "pre-T") (:end . 153)\n  (:start . 148) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "FTOC") (:form . "FTOC") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x584.6.1) (:span 120 123)))\n (:nscopes ((:id . :x584.6.1) (:span 120 147)))\n (:identifiers (:sid . :s584.6) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005402@unknown@formal@none@1@S@These cells had properties of both natural killer (NK) and pre-T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "pre-t") (:form . "pre-T") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s584.7) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005403@unknown@formal@none@1@S@These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "T/NK") (:form . "T/NK") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "checkpoint") (:form . "checkpoint") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x584.8.1) (:span 15 22)))\n (:hscopes ((:id . :x584.8.1) (:span 15 123)))\n (:identifiers (:sid . :s584.8) (:did . :|10329625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005404@unknown@formal@none@1@S@Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.@(((:tag . "NNP") (:stem . "Rel/NF-kappaB") (:form . "Rel/NF-kappaB")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jagged1") (:form . "Jagged1") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s585.1) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005405@unknown@formal@none@1@S@Jagged1 belongs to the DSL family of ligands for Notch receptors that control the proliferation and differentiation of various cell lineages.@(((:tag . "NNP") (:stem . "Jagged1") (:form . "Jagged1") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DSL") (:form . "DSL") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 115) (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s585.2) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005406@unknown@formal@none@1@S@However, little is known about the transcription factors that regulate its expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s585.3) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005407@unknown@formal@none@1@S@Here, we show that Jagged1 is a Rel/NF-kappaB-responsive gene.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "jagged1") (:form . "Jagged1") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rel/nf-kappab-responsive")\n  (:form . "Rel/NF-kappaB-responsive") (:end . 56) (:start . 32) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s585.4) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005408@unknown@formal@none@1@S@Both c-Rel and RelA induced jagged1 gene expression, whereas a mutant defective for transactivation did not.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "jagged1") (:form . "jagged1") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 99) (:start . 84) (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x585.5.1) (:span 104 107)))\n (:nscopes ((:id . :x585.5.1) (:span 104 107)))\n (:identifiers (:sid . :s585.5) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005410@unknown@formal@none@1@S@Cell surface expression of Jagged1 in c-Rel-expressing cell monolayers led to a functional interaction with lymphocytes expressing the Notch1/TAN-1 receptor.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "jagged1") (:form . "Jagged1") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-rel-expressing") (:form . "c-Rel-expressing")\n  (:end . 54) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monolayer") (:form . "monolayers") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 119)\n  (:start . 108) (:id . 57))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 130)\n  (:start . 120) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "NN") (:stem . "notch1/tan-1") (:form . "Notch1/TAN-1") (:end . 147)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 156)\n  (:start . 148) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s585.7) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005411@unknown@formal@none@1@S@This correlated with the initiation of signaling downstream of Notch, as evidenced by increased levels of HES-1 transcripts in co-cultivated T cells and of CD23 transcripts in co-cultivated B cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hes-1") (:form . "HES-1") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "co-cultivated") (:form . "co-cultivated")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 172)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "co-cultivated") (:form . "co-cultivated")\n  (:end . 189) (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 191) (:start . 190)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s585.8) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005412@unknown@formal@none@1@S@Consistent with its Rel/NF-kappaB-dependent induction, Jagged1 was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rel/nf-kappab-dependent")\n  (:form . "Rel/NF-kappaB-dependent") (:end . 43) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 53)\n  (:start . 44) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jagged1") (:form . "Jagged1") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 154) (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s585.9) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005413@unknown@formal@none@1@S@These results demonstrate that c-Rel can trigger the Notch signaling pathway in neighboring cells by inducing jagged1 gene expression, and suggest a role for Jagged1 in B-cell activation, differentiation or function.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "jagged1") (:form . "jagged1") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "jagged1") (:form . "Jagged1") (:end . 165)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 186)\n  (:start . 176) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 203) (:start . 188) (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 215)\n  (:start . 207) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x585.10.1) (:span 139 146)))\n (:hscopes ((:id . :x585.10.1) (:span 139 215)))\n (:identifiers (:sid . :s585.10) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005414@unknown@formal@none@1@S@These findings also highlight the potential for an interplay between the Notch and NF-kappaB signaling pathways in the immune system.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "highlight") (:form . "highlight") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x585.11.1) (:span 34 43)))\n (:hscopes ((:id . :x585.11.1) (:span 34 132)))\n (:identifiers (:sid . :s585.11) (:did . :|10329626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005415@unknown@formal@none@1@S@Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s586.1) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005416@unknown@formal@none@1@S@BACKGROUND: IL-5 is fundamentally involved in eosinophilic inflammation.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "fundamentally") (:form . "fundamentally")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s586.2) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005417@unknown@formal@none@1@S@Control of IL-5 production may be effective for the management of allergic diseases.@(((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "management") (:form . "management") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x586.3.1) (:span 27 30)))\n (:hscopes ((:id . :x586.3.1) (:span 27 83)))\n (:identifiers (:sid . :s586.3) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005418@unknown@formal@none@1@S@OBJECTIVE: We aimed to find the transcriptional mechanisms that regulate the IL-5 gene to selectively control IL-5 synthesis.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "aim") (:form . "aimed") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 47) (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s586.4) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005420@unknown@formal@none@1@S@RESULTS: A human IL-5 promoter/enhancer-luciferase gene construct, pIL-5(-511)Luc, was transcribed on activation of IL-5-producing T-cell clones, but not IL-5-nonproducing clones.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter/enhancer-luciferase")\n  (:form . "promoter/enhancer-luciferase") (:end . 50) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pIL-5(-511)Luc") (:form . "pIL-5(-511)Luc")\n  (:end . 81) (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "il-5-producing") (:form . "IL-5-producing")\n  (:end . 130) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 144)\n  (:start . 138) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "il-5-nonproducing") (:form . "IL-5-nonproducing")\n  (:end . 171) (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 178)\n  (:start . 172) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x586.6.1) (:span 150 153)))\n (:nscopes ((:id . :x586.6.1) (:span 150 178)))\n (:identifiers (:sid . :s586.6) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005421@unknown@formal@none@1@S@pIL-5(-511)Luc was transcribed by T-cell hybridomas derived from fusion between IL-5-producing T-cell clones and an IL-5 gene-nonexpressing T-cell line, but not by hybridomas derived from IL-5-nonproducing T-cell clones.@(((:tag . "NN") (:stem . "pIL-5(-511)Luc") (:form . "pIL-5(-511)Luc")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "JJ") (:stem . "il-5-producing") (:form . "IL-5-producing")\n  (:end . 94) (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 101)\n  (:start . 95) (:id . 53))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 108)\n  (:start . 102) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "gene-nonexpressing") (:form . "gene-nonexpressing")\n  (:end . 139) (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 146)\n  (:start . 140) (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 151) (:start . 147)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 174)\n  (:start . 164) (:id . 65))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 182)\n  (:start . 175) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 187) (:start . 183)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "il-5-nonproducing") (:form . "IL-5-nonproducing")\n  (:end . 205) (:start . 188) (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 212)\n  (:start . 206) (:id . 69))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 219)\n  (:start . 213) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x586.7.1) (:span 157 160)))\n (:nscopes ((:id . :x586.7.1) (:span 157 219)))\n (:identifiers (:sid . :s586.7) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005422@unknown@formal@none@1@S@IL-5 synthesis was not only induced by T-cell receptor stimulation but also by IL-2 receptor stimulation.@(((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s586.8) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005423@unknown@formal@none@1@S@Binding of NF-AT, NF-kappaB, and AP-1 was induced by T-cell receptor (TcR) stimulation, although there was no significant upregulation of binding by IL-2 stimulation.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 86)\n  (:start . 75) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 96)\n  (:start . 88) (:id . 60))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 121)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 134)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 165)\n  (:start . 154) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x586.9.1) (:span 107 109)))\n (:nscopes ((:id . :x586.9.1) (:span 107 165)))\n (:identifiers (:sid . :s586.9) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005424@unknown@formal@none@1@S@CONCLUSION: IL-5 synthesis by human helper T cells is regulated at the transcriptional level.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 86) (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s586.10) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005425@unknown@formal@none@1@S@A unique transcriptional mechanism distinct from those regulating the IL-2 or IL-4 genes seems to control the IL-5 gene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 65)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x586.11.2) (:span 89 94))\n  ((:id . :x586.11.1) (:span 75 77)))\n (:hscopes ((:id . :x586.11.1) (:span 70 82))\n  ((:id . :x586.11.2) (:span 0 119)))\n (:identifiers (:sid . :s586.11) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005426@unknown@formal@none@1@S@Selective regulation of IL-5 gene transcription may be useful for treating eosinophlic inflammation.@(((:tag . "JJ") (:stem . "selective") (:form . "Selective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "treat") (:form . "treating") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "eosinophlic") (:form . "eosinophlic") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 99)\n  (:start . 87) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x586.12.1) (:span 48 51)))\n (:hscopes ((:id . :x586.12.1) (:span 48 99)))\n (:identifiers (:sid . :s586.12) (:did . :|10329845|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005427@unknown@formal@none@1@S@Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "flow-induced") (:form . "flow-induced") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "HAEC") (:form . "HAEC") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s587.1) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005428@unknown@formal@none@1@S@We recently reported that prolonged exposure of human aortic endothelial cells (HAEC) to low shear stress flow patterns is associated with a sustained increase in the activated form of the transcriptional regulator nuclear factor-kappaB (NF-kappaB).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "aortic") (:form . "aortic") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 72)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HAEC") (:form . "HAEC") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "activated") (:form . "activated") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 204) (:start . 189) (:id . 74))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 214)\n  (:start . 205) (:id . 75))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 222)\n  (:start . 215) (:id . 76))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 236) (:start . 223) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 238) (:start . 237)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 247)\n  (:start . 238) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s587.2) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005430@unknown@formal@none@1@S@Before exposure to low shear (2 dyn/cm2) for 6 h, HAEC were preincubated with or without the antioxidants pyrrolidine dithiocarbamate (PDTC) or N-acetyl-L-cysteine (NAC).@(((:tag . "IN") (:stem . "before") (:form . "Before") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dyn/cm2") (:form . "dyn/cm2") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HAEC") (:form . "HAEC") (:end . 54) (:start . 50)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 72)\n  (:start . 60) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 80) (:start . 78)\n  (:id . 59))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 88)\n  (:start . 81) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 105)\n  (:start . 93) (:id . 62))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 117)\n  (:start . 106) (:id . 63))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 133) (:start . 118) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 163) (:start . 144) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 168) (:start . 165)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x587.4.1) (:span 81 88)))\n (:nscopes ((:id . :x587.4.1) (:span 81 169)))\n (:identifiers (:sid . :s587.4) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005431@unknown@formal@none@1@S@PDTC strongly inhibited low shear-induced activation of NF-kappaB, expression of VCAM-1, and EC-Mn adhesion.@(((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "shear-induced") (:form . "shear-induced")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "EC-Mn") (:form . "EC-Mn") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s587.5) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005432@unknown@formal@none@1@S@Paradoxically, NAC exerted a positive effect on low shear-induced VCAM-1 expression and EC-Mn adhesion and only slightly downregulated NF-kappaB activation.@(((:tag . "RB") (:stem . "paradoxically") (:form . "Paradoxically")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "exert") (:form . "exerted") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "shear-induced") (:form . "shear-induced")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ec-mn") (:form . "EC-Mn") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "VBD") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 134) (:start . 121) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 144)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s587.6) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005433@unknown@formal@none@1@S@However, cytokine-induced NF-kappaB activation and VCAM-1 expression are blocked by both PDTC and NAC.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 25) (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s587.7) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005434@unknown@formal@none@1@S@These data suggest that NF-kappaB plays a key role in low shear-induced VCAM-1 expression and that pathways mediating low shear- and cytokine-induced EC-Mn adhesion may be differentially regulated.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "shear-induced") (:form . "shear-induced")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "shear-") (:form . "shear-") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 149) (:start . 133) (:id . 63))\n ((:tag . "NNP") (:stem . "EC-Mn") (:form . "EC-Mn") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 186) (:start . 172) (:id . 68))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x587.8.1) (:span 165 168))\n  ((:id . :x587.8.2) (:span 11 18)))\n (:hscopes ((:id . :x587.8.1) (:span 99 196))\n  ((:id . :x587.8.2) (:span 11 196)))\n (:identifiers (:sid . :s587.8) (:did . :|10329958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005435@unknown@formal@none@1@S@Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "beta-catenin-lymphoid")\n  (:form . "beta-catenin-lymphoid") (:end . 59) (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 68)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 75)\n  (:start . 69) (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 77) (:start . 76)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x588.1.1) (:span 92 95)))\n (:nscopes ((:id . :x588.1.1) (:span 92 140)))\n (:identifiers (:sid . :s588.1) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005436@unknown@formal@none@1@S@In response to activation of the Wnt signaling pathway, beta-catenin accumulates in the nucleus, where it cooperates with LEF/TCF (for lymphoid enhancer factor and T-cell factor) transcription factors to activate gene expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wnt") (:form . "Wnt") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 68)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "accumulate") (:form . "accumulates") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 102)\n  (:start . 97) (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LEF/TCF") (:form . "LEF/TCF") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 177)\n  (:start . 171) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 192) (:start . 179) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 200)\n  (:start . 193) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 212)\n  (:start . 204) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 217) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 228)\n  (:start . 218) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s588.2) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005437@unknown@formal@none@1@S@The mechanisms by which beta-catenin undergoes this shift in location and participates in activation of gene transcription are unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "undergo") (:form . "undergoes") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 86)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x588.3.1) (:span 127 134)))\n (:hscopes ((:id . :x588.3.1) (:span 0 134)))\n (:identifiers (:sid . :s588.3) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005438@unknown@formal@none@1@S@We demonstrate here that beta-catenin can be imported into the nucleus independently of LEF/TCF binding, and it may also be exported from nuclei.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "import") (:form . "imported") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 84) (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LEF/TCF") (:form . "LEF/TCF") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "export") (:form . "exported") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x588.4.1) (:span 112 115)))\n (:hscopes ((:id . :x588.4.1) (:span 109 144)))\n (:identifiers (:sid . :s588.4) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005440@unknown@formal@none@1@S@This Delta19 beta-catenin mutant localizes to the nucleus because it may not be efficiently sequestered in the cytoplasm.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "delta19") (:form . "Delta19") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "VBZ") (:stem . "localize") (:form . "localizes") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "VBN") (:stem . "sequester") (:form . "sequestered") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x588.6.2) (:span 69 72)))\n (:ncues ((:id . :x588.6.1) (:span 73 76)))\n (:hscopes ((:id . :x588.6.2) (:span 66 120)))\n (:nscopes ((:id . :x588.6.1) (:span 73 120)))\n (:identifiers (:sid . :s588.6) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005441@unknown@formal@none@1@S@The nuclear localization of Delta19 definitively demonstrates that the mechanisms by which beta-catenin localizes in the nucleus are completely independent of LEF/TCF factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "delta19") (:form . "Delta19") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "RB") (:stem . "definitively") (:form . "definitively") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 61)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 103)\n  (:start . 91) (:id . 54))\n ((:tag . "VBZ") (:stem . "localize") (:form . "localizes") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 155)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LEF/TCF") (:form . "LEF/TCF") (:end . 166)\n  (:start . 159) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 174)\n  (:start . 167) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s588.7) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005442@unknown@formal@none@1@S@beta-Catenin and LEF-1 complexes can activate reporter gene expression in a transformed T-lymphocyte cell line (Jurkat) but not in normal T lymphocytes, even though both factors are nuclear.@(((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-Catenin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lef-1") (:form . "LEF-1") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 100) (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 151)\n  (:start . 140) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 181) (:start . 178)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 189)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x588.8.1) (:span 124 127)))\n (:nscopes ((:id . :x588.8.1) (:span 124 151)))\n (:identifiers (:sid . :s588.8) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005443@unknown@formal@none@1@S@Thus, localization of both factors to the nucleus is not sufficient for activation of gene expression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 18)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x588.9.1) (:span 53 56)))\n (:nscopes ((:id . :x588.9.1) (:span 53 101)))\n (:identifiers (:sid . :s588.9) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005444@unknown@formal@none@1@S@Excess beta-catenin can squelch reporter gene activation by LEF-1-beta-catenin complexes but not activation by the transcription factor VP16.@(((:tag . "JJ") (:stem . "excess") (:form . "Excess") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "beta-catenin") (:form . "beta-catenin") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VB") (:stem . "squelch") (:form . "squelch") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LEF-1-beta-catenin") (:form . "LEF-1-beta-catenin")\n  (:end . 78) (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 88)\n  (:start . 79) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "vp16") (:form . "VP16") (:end . 140) (:start . 136)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x588.10.1) (:span 93 96)))\n (:nscopes ((:id . :x588.10.1) (:span 93 140)))\n (:identifiers (:sid . :s588.10) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005445@unknown@formal@none@1@S@Taken together, these data suggest that a third component is necessary for gene activation and that this third component may vary with cell type.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "VB") (:stem . "vary") (:form . "vary") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x588.11.1) (:span 121 124))\n  ((:id . :x588.11.2) (:span 27 34)))\n (:hscopes ((:id . :x588.11.1) (:span 121 144))\n  ((:id . :x588.11.2) (:span 27 144)))\n (:identifiers (:sid . :s588.11) (:did . :|10330189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005446@unknown@formal@none@1@S@Paradoxical priming effects of IL-10 on cytokine production.@(((:tag . "JJ") (:stem . "paradoxical") (:form . "Paradoxical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s589.1) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005447@unknown@formal@none@1@S@IL-10 is a well-known immunosuppressive and/or anti-inflammatory cytokine.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "well-known") (:form . "well-known") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 39) (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 64) (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s589.2) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005448@unknown@formal@none@1@S@However, we report in vitro experimental studies in which IL-10 primed leukocytes and led to an enhanced production of tumor necrosis factor (TNF) upon further stimulation by lipopolysaccharide (LPS).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "prim") (:form . "primed") (:end . 70) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 171)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 193) (:start . 175) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s589.3) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005450@unknown@formal@none@1@S@In addition to TNF, LPS-induced IL-6 and spontaneous IL-1ra production were also enhanced.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "spontaneous") (:form . "spontaneous") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "IL-1ra") (:form . "IL-1ra") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s589.5) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005451@unknown@formal@none@1@S@When isolated PBMC were first cultured for 20 h in the presence of IL-10 on Teflon to prevent adherence, washed to remove IL-10 and then further cultured in plastic dishes for an additional 20 h in the presence of LPS or IL-1beta, an enhanced release of TNF was observed.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . 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5005452@unknown@formal@none@1@S@This was not the case when PBMC were pre-cultured in plastic multidishes in the presence of IL-10.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pre-cultured") (:form . "pre-cultured") (:end . 49)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "plastic") (:form . "plastic") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "multidish") (:form . "multidishes") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x589.7.1) (:span 9 12)))\n (:nscopes ((:id . :x589.7.1) (:span 9 97)))\n (:identifiers (:sid . :s589.7) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005453@unknown@formal@none@1@S@TNF mRNA expression induced by LPS was decreased when the pre-treatment of PBMC with IL-10 was performed on plastic, whereas this was not the case when cells were pre-cultured with IL-10 on Teflon.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pre-treatment") (:form . "pre-treatment")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "plastic") (:form . "plastic") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 162) (:start . 158)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "pre-cultured") (:form . "pre-cultured") (:end . 175)\n  (:start . 163) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 186)\n  (:start . 181) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 189) (:start . 187)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Teflon") (:form . "Teflon") (:end . 196)\n  (:start . 190) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x589.8.1) (:span 134 137)))\n (:nscopes ((:id . :x589.8.1) (:span 134 196)))\n (:identifiers (:sid . :s589.8) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005454@unknown@formal@none@1@S@Furthermore, NFkappaB translocation following LPS activation was higher after IL-10 pre-treatment on Teflon than on plastic.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 71) (:start . 65)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pre-treatment") (:form . "pre-treatment")\n  (:end . 97) (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Teflon") (:form . "Teflon") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 112) (:start . 108)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "plastic") (:form . "plastic") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s589.9) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005455@unknown@formal@none@1@S@Interestingly, an enhanced frequency of CD16 and CD68(+) cells among the CD14(+) cells was observed in the presence of IL-10, independently of the pre-culture conditions of the PBMC.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD16") (:form . "CD16") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "CD68(+)") (:form . "CD68(+)") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "CD14(+)") (:form . "CD14(+)") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 139) (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "pre-culture") (:form . "pre-culture") (:end . 158)\n  (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s589.10) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005456@unknown@formal@none@1@S@Altogether, these results indicate that the IL-10-induced up-regulation of cytokine production depends on the prevention of monocyte adherence by red cells in the whole blood assays or by cultures of PBMC on Teflon.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "il-10-induced") (:form . "IL-10-induced")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 142)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 181)\n  (:start . 175) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 196)\n  (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 204) (:start . 200)\n  (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Teflon") (:form . "Teflon") (:end . 214)\n  (:start . 208) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x589.11.1) (:span 182 184))\n  ((:id . :x589.11.2) (:span 26 39)))\n (:hscopes ((:id . :x589.11.1) (:span 143 214))\n  ((:id . :x589.11.2) (:span 26 214)))\n (:identifiers (:sid . :s589.11) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005457@unknown@formal@none@1@S@In contrast, the adherence parameter has no effect on the IL-10-induced modulation of some monocyte surface markers.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "il-10-induced") (:form . "IL-10-induced")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x589.12.1) (:span 41 43)))\n (:nscopes ((:id . :x589.12.1) (:span 41 115)))\n (:identifiers (:sid . :s589.12) (:did . :|10330274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005458@unknown@formal@none@1@S@Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 31)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 78) (:start . 64) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 91)\n  (:start . 85) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 112)\n  (:start . 105) (:id . 55))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 121)\n  (:start . 113) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 140) (:start . 136)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s590.1) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005460@unknown@formal@none@1@S@We have localized a 317 base pair cis-acting regulatory element, HS I, associated with a hematopoietic-specific DNase I hypersensitive site, which lies approx. 3.7 kilobases upstream of the murine hematopoietic-specific GATA-1 IE promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "317") (:form . "317") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 81)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 111) (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 134) (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . "RB") (:stem . "approx.") (:form . "approx.") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . "CD") (:stem . "3.7") (:form . "3.7") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 173)\n  (:start . 164) (:id . 69))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 182)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 196)\n  (:start . 190) (:id . 73))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 219) (:start . 197) (:id . 74))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 226)\n  (:start . 220) (:id . 75))\n ((:tag . "NN") (:stem . "ie") (:form . "IE") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 238)\n  (:start . 230) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s590.3) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005461@unknown@formal@none@1@S@HS I directs high-level expression of reporter GATA-1/lacZ genes to primitive and definitive erythroid cells and megakaryocytes in transgenic mice.@(((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 12)\n  (:start . 5) (:id . 44))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "GATA-1/lacZ") (:form . "GATA-1/lacZ") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "definitive") (:form . "definitive") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 127) (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 146)\n  (:start . 142) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s590.4) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005462@unknown@formal@none@1@S@Comparative sequence analysis of HS I between human and mouse shows approx. 63% nucleotide identity with a more conserved core of 169 base pairs (86% identity).@(((:tag . "JJ") (:stem . "comparative") (:form . "Comparative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "approx.") (:form . "approx.") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "CD") (:stem . "63") (:form . "63") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "CD") (:stem . "169") (:form . "169") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "CD") (:stem . "86") (:form . "86") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 158)\n  (:start . 150) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s590.5) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005463@unknown@formal@none@1@S@This core contains a GATA site separated by 10 base pairs from an E-box motif.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "e-box") (:form . "E-box") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s590.6) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005464@unknown@formal@none@1@S@The composite motif binds a multi-protein hematopoietic-specific transcription factor complex which includes GATA-1, SCL/tal-1, E2A, Lmo2 and Ldb-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "multi-protein") (:form . "multi-protein")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 64) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 85)\n  (:start . 79) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 93)\n  (:start . 86) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 108)\n  (:start . 100) (:id . 53))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 115)\n  (:start . 109) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SCL/tal-1") (:form . "SCL/tal-1") (:end . 126)\n  (:start . 117) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E2A") (:form . "E2A") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lmo2") (:form . "Lmo2") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ldb-1") (:form . "Ldb-1") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s590.7) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005465@unknown@formal@none@1@S@Point mutations of the GATA site abolishes HS I function, whereas mutation of the E-box motif still allows reporter gene expression in both lineages.@(((:tag . "NNP") (:stem . "Point") (:form . "Point") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "hs") (:form . "HS") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "e-box") (:form . "E-box") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s590.8) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005466@unknown@formal@none@1@S@Strict dependence of HS I activity on a GATA site implies that assembly of a protein complex containing a GATA-factor, presumably GATA-1 or GATA-2, is critical to activating or maintaining its function.@(((:tag . "JJ") (:stem . "strict") (:form . "Strict") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata-factor") (:form . "GATA-factor") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 173)\n  (:start . 163) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 188)\n  (:start . 177) (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 192) (:start . 189)\n  (:id . 74))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 201)\n  (:start . 193) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x590.9.1) (:span 137 139))\n  ((:id . :x590.9.2) (:span 119 129)) ((:id . :x590.9.3) (:span 50 57)))\n (:hscopes ((:id . :x590.9.1) (:span 130 146))\n  ((:id . :x590.9.2) (:span 119 146)) ((:id . :x590.9.3) (:span 50 201)))\n (:identifiers (:sid . :s590.9) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005467@unknown@formal@none@1@S@Further dissection of the 317 base pair region demonstrates that, whereas all 317 base pairs are required for expression in megakaryocytes, only the 5' 62 base pairs are needed for erythroid-specific reporter expression.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dissection") (:form . "dissection") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "317") (:form . "317") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "CD") (:stem . "317") (:form . "317") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 138) (:start . 124) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "CD") (:stem . "62") (:form . "62") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 159) (:start . 155)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 165)\n  (:start . 160) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 176)\n  (:start . 170) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 180) (:start . 177)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 199) (:start . 181) (:id . 75))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 208)\n  (:start . 200) (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 219)\n  (:start . 209) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s590.10) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005468@unknown@formal@none@1@S@These findings demonstrate differential lineage requirements for expression within the HS I element.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 39)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 60)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 82)\n  (:start . 76) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s590.11) (:did . :|10331989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005470@unknown@formal@none@1@S@Mobilization of nuclear factor-kappaB (NF-kappaB) activates transcription of genes encoding endothelial adhesion molecules and chemokines that contribute to monocyte infiltration critical in atherogenesis.@(((:tag . "NN") (:stem . "mobilization") (:form . "Mobilization") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 37) (:start . 24) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 112)\n  (:start . 104) (:id . 55))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 122)\n  (:start . 113) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 137)\n  (:start . 127) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 153)\n  (:start . 143) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 61))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 165)\n  (:start . 157) (:id . 62))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 178)\n  (:start . 166) (:id . 63))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 187)\n  (:start . 179) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 65))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 204) (:start . 191) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s591.2) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005471@unknown@formal@none@1@S@Inhibition of NF-kappaB has been achieved by pharmacological and genetic approaches; however, monocyte interactions with activated endothelium in shear flow following gene transfer of the NF-kappaB inhibitor IkappaB-alpha have not been studied.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pharmacological") (:form . "pharmacological")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 115)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 130)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 142)\n  (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 156) (:start . 152)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 166)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 180)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 197)\n  (:start . 188) (:id . 69))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 207)\n  (:start . 198) (:id . 70))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 221) (:start . 208) (:id . 71))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 226) (:start . 222)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 230) (:start . 227)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 235) (:start . 231)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 243)\n  (:start . 236) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x591.3.1) (:span 227 230)))\n (:nscopes ((:id . :x591.3.1) (:span 94 243)))\n (:identifiers (:sid . :s591.3) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005472@unknown@formal@none@1@S@We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha (TNF-alpha)-induced degradation of IkappaB-alpha and suppressed the upregulation of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 (MCP-1) and growth-related activity-alpha (GRO-alpha) by TNF-alpha.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . 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5005473@unknown@formal@none@1@S@This was associated with a reduction in endothelial MCP-1 secretion and GRO-alpha immobilization.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GRO-alpha") (:form . "GRO-alpha") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "immobilization") (:form . "immobilization")\n  (:end . 96) (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s591.5) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005474@unknown@formal@none@1@S@Adhesion assays under physiological shear flow conditions showed that firm arrest, spreading, and transmigration of monocytes on TNF-alpha-activated endothelium was markedly inhibited by IkappaB-alpha overexpression.@(((:tag . "NNP") (:stem . "Adhesion") (:form . "Adhesion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 64) (:start . 58)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "firm") (:form . "firm") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "spreading") (:form . "spreading") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transmigration") (:form . "transmigration")\n  (:end . 112) (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tnf-alpha-activated")\n  (:form . "TNF-alpha-activated") (:end . 148) (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 160)\n  (:start . 149) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 164) (:start . 161)\n  (:id . 63))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 173)\n  (:start . 165) (:id . 64))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 183)\n  (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 200) (:start . 187) (:id . 67))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 215) (:start . 201) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s591.6) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005475@unknown@formal@none@1@S@Inhibition with monoclonal antibodies and peptide antagonists inferred that this was due to reduced expression of Ig integrin ligand as well as of chemokines specifically involved in these events.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . "VBD") (:stem . "infer") (:form . "inferred") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 80) (:start . 76)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 157)\n  (:start . 147) (:id . 65))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 170)\n  (:start . 158) (:id . 66))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 179)\n  (:start . 171) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 195)\n  (:start . 189) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s591.7) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005476@unknown@formal@none@1@S@In contrast, rolling of monocytes was increased by IkappaB-alpha transfer and was partly mediated by P-selectin; however, it appeared to be unaffected by the inhibition of E-selectin induction.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rolling") (:form . "rolling") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 150)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 182)\n  (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 192)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x591.8.1) (:span 125 133)))\n (:hscopes ((:id . :x591.8.1) (:span 122 192)))\n (:identifiers (:sid . :s591.8) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005477@unknown@formal@none@1@S@Thus, our data provide novel evidence that selective modulation of NF-kappaB by adenoviral transfer of IkappaB-alpha impairs the expression of multiple endothelial gene products required for subsequent monocyte arrest and emigration in shear flow and thus for monocyte infiltration in atherosclerotic plaques.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adenoviral") (:form . "adenoviral") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 163)\n  (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 186)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 190) (:start . 187)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 201)\n  (:start . 191) (:id . 69))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 210)\n  (:start . 202) (:id . 70))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 217)\n  (:start . 211) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 72))\n ((:tag . "NN") (:stem . "emigration") (:form . "emigration") (:end . 232)\n  (:start . 222) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 74))\n ((:tag . "NN") (:stem . "shear") (:form . "shear") (:end . 241)\n  (:start . 236) (:id . 75))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 246) (:start . 242)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 250) (:start . 247)\n  (:id . 77))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 255) (:start . 251)\n  (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 259) (:start . 256)\n  (:id . 79))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 268)\n  (:start . 260) (:id . 80))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 281)\n  (:start . 269) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 284) (:start . 282)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 300) (:start . 285) (:id . 83))\n ((:tag . "NNS") (:stem . "plaque") (:form . "plaques") (:end . 308)\n  (:start . 301) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s591.9) (:did . :|10339475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005478@unknown@formal@none@1@S@SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity.@(((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s592.1) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005480@unknown@formal@none@1@S@Following T cell antigen receptor stimulation, SLP-76 and Vav both undergo tyrosine phosphorylation and associate with each other via the SH2 domain of Vav and phosphorylated tyrosines of SLP-76.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 99) (:start . 84) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "associate") (:form . "associate") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 174) (:start . 160) (:id . 68))\n ((:tag . "NNS") (:stem . "tyrosine") (:form . "tyrosines") (:end . 184)\n  (:start . 175) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 194)\n  (:start . 188) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s592.3) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005481@unknown@formal@none@1@S@Furthermore, SLP-76 and Vav have a synergistic effect on interleukin (IL)-2 promoter activity in T cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "IL)-2") (:form . "IL)-2") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s592.4) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005482@unknown@formal@none@1@S@In this report, we show that two tyrosines, Tyr-113 and Tyr-128, of SLP-76 are required for its binding to Vav, both in vitro and in intact cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "tyrosine") (:form . "tyrosines") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tyr-113") (:form . "Tyr-113") (:end . 51)\n  (:start . 44) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tyr-128") (:form . "Tyr-128") (:end . 63)\n  (:start . 56) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 74)\n  (:start . 68) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 87)\n  (:start . 79) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 116) (:start . 112)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 125)\n  (:start . 120) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 139)\n  (:start . 133) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s592.5) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005483@unknown@formal@none@1@S@Surprisingly, we find also that the interaction between SLP-76 and Vav is not required for their cooperation in augmenting IL-2 promoter activity, as the two molecules appear to function in different signaling pathways upstream of IL-2 gene expression.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 96)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "augment") (:form . "augmenting") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 174)\n  (:start . 168) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 186)\n  (:start . 178) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 199)\n  (:start . 190) (:id . 74))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 227)\n  (:start . 219) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 235) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 240) (:start . 236)\n  (:id . 80))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 251)\n  (:start . 241) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x592.6.1) (:span 168 174)))\n (:ncues ((:id . :x592.6.2) (:span 74 77)))\n (:hscopes ((:id . :x592.6.1) (:span 150 251)))\n (:nscopes ((:id . :x592.6.2) (:span 32 145)))\n (:identifiers (:sid . :s592.6) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005484@unknown@formal@none@1@S@Overexpression of SLP-76 in the Jurkat T cell line potentiates the activities of both nuclear factor of activated T cells and AP-1 transcription factors.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s592.7) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005485@unknown@formal@none@1@S@In contrast, overexpression of Vav leads to enhanced nuclear factor of activated T cells activity without affecting AP-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x592.8.1) (:span 98 105)))\n (:nscopes ((:id . :x592.8.1) (:span 98 120)))\n (:identifiers (:sid . :s592.8) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005486@unknown@formal@none@1@S@Additionally, overexpression of Vav, but not SLP-76, augments CD28-induced IL-2 promoter activity.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "cd28-induced") (:form . "CD28-induced") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x592.9.1) (:span 41 44)))\n (:nscopes ((:id . :x592.9.1) (:span 41 51)))\n (:identifiers (:sid . :s592.9) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005487@unknown@formal@none@1@S@These findings suggest that the synergy between SLP-76 and Vav in regulating IL-2 gene expression reflects the cooperation between different signaling pathways.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "SLP-76") (:form . "SLP-76") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 150)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x592.10.1) (:span 15 22)))\n (:hscopes ((:id . :x592.10.1) (:span 15 159)))\n (:identifiers (:sid . :s592.10) (:did . :|10347175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005488@unknown@formal@none@1@S@Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing.@(((:tag . "VBN") (:stem . "target") (:form . "Targeted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "remodeling") (:form . "remodeling") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 69)\n  (:start . 60) (:id . 49))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 78)\n  (:start . 70) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 88)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 113)\n  (:start . 104) (:id . 54))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 123)\n  (:start . 114) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s593.1) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005490@unknown@formal@none@1@S@One feature of this chromatin reorganization is the formation of DNase 1 hypersensitive sites in the regions of active globin gene promoters.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "reorganization") (:form . "reorganization")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 87) (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s593.3) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005491@unknown@formal@none@1@S@This reorganization requires the globin locus control region and is associated with normal expression of the beta-like globin genes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reorganization") (:form . "reorganization")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "beta-like") (:form . "beta-like") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s593.4) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005492@unknown@formal@none@1@S@To determine whether it is possible to artificially enhance the opening of the chromatin structure of a minimal beta-globin promoter, we placed a 101bp, erythroid-specific DNase 1 hypersensitive site-forming element (HSFE) immediately upstream of the beta-globin promoter and gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "artificially") (:form . "artificially") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "opening") (:form . "opening") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "place") (:form . "placed") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "101bp") (:form . "101bp") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 171) (:start . 153) (:id . 68))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 194) (:start . 180) (:id . 71))\n ((:tag . "JJ") (:stem . "site-forming") (:form . "site-forming") (:end . 207)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 215)\n  (:start . 208) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 217) (:start . 216)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HSFE") (:form . "HSFE") (:end . 221) (:start . 217)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 76))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 234)\n  (:start . 223) (:id . 77))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 243)\n  (:start . 235) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 80))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 262)\n  (:start . 251) (:id . 81))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 271)\n  (:start . 263) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 275) (:start . 272)\n  (:id . 83))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 280) (:start . 276)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x593.5.1) (:span 27 35)) ((:id . :x593.5.2) (:span 13 20)))\n (:hscopes ((:id . :x593.5.1) (:span 27 132))\n  ((:id . :x593.5.2) (:span 13 132)))\n (:identifiers (:sid . :s593.5) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005493@unknown@formal@none@1@S@This element includes binding sites for NF-E2, AP-1, GATA-1 and Sp-1.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-E2") (:form . "NF-E2") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sp-1") (:form . "Sp-1") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s593.6) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005494@unknown@formal@none@1@S@Constructs were stably transfected into murine erythroleukemia cells and promoter chromatin structure and gene expression were analyzed.@(((:tag . "NNS") (:stem . "construct") (:form . "Constructs") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 62) (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 101)\n  (:start . 92) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 126) (:start . 122)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 135)\n  (:start . 127) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s593.7) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005495@unknown@formal@none@1@S@The HSFE induced an area of enhanced DNase 1 hypersensitivity extending from the transcriptional start site to -300bp of the artificial promoter and significantly increased the proportion of beta-globin promoters in an open chromatin configuration.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HSFE") (:form . "HSFE") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 61) (:start . 45) (:id . 51))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 96) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "-300bp") (:form . "-300bp") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "artificial") (:form . "artificial") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 162) (:start . 149) (:id . 65))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 187)\n  (:start . 177) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 202)\n  (:start . 191) (:id . 70))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 212)\n  (:start . 203) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 218) (:start . 216)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 233)\n  (:start . 224) (:id . 75))\n ((:tag . "NN") (:stem . "configuration") (:form . "configuration")\n  (:end . 247) (:start . 234) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s593.8) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005496@unknown@formal@none@1@S@This remodeling of promoter chromatin structure resulted in 3-fold increases in beta-globin gene transcription and induction, and inhibited long-term beta-globin gene silencing.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "remodeling") (:form . "remodeling") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "3-fold") (:form . "3-fold") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 91)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 149)\n  (:start . 140) (:id . 61))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 161)\n  (:start . 150) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 166) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 176)\n  (:start . 167) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s593.9) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005497@unknown@formal@none@1@S@These results indicate that a relatively small cis-acting element is able to enhance remodeling of promoter chromatin structure resulting in increased beta-globin gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "remodeling") (:form . "remodeling") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 137)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 150)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 162)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 167) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x593.10.1) (:span 14 27)))\n (:hscopes ((:id . :x593.10.1) (:span 14 178)))\n (:identifiers (:sid . :s593.10) (:did . :|10349513|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005498@unknown@formal@none@1@S@In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "T-lineage") (:form . "T-lineage") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 183)\n  (:start . 174) (:id . 70))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 212)\n  (:start . 204) (:id . 76))\n ((:tag . "NN") (:stem . "thymopoiesis") (:form . "thymopoiesis") (:end . 225)\n  (:start . 213) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x594.1.1) (:span 197 200)))\n (:nscopes ((:id . :x594.1.1) (:span 197 225)))\n (:identifiers (:sid . :s594.1) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005500@unknown@formal@none@1@S@Transgene expression did not affect the thymic development, but led to lowered numbers of splenic T cells and to a dramatic decrease in the ex vivo proliferative response of splenic T lymphocytes.@(((:tag . "NNP") (:stem . "Transgene") (:form . "Transgene") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lowered") (:form . "lowered") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 161) (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 170)\n  (:start . 162) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 181)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 195)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x594.3.1) (:span 25 28)))\n (:nscopes ((:id . :x594.3.1) (:span 25 58)))\n (:identifiers (:sid . :s594.3) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005501@unknown@formal@none@1@S@Analysis of IL-2 and IL-2R alpha expression demonstrated that the perturbation of the proliferation response was not attributable to an abnormal expression of these genes.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "perturbation") (:form . "perturbation") (:end . 78)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 99) (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 129)\n  (:start . 117) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x594.4.1) (:span 113 116)))\n (:nscopes ((:id . :x594.4.1) (:span 113 170)))\n (:identifiers (:sid . :s594.4) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005502@unknown@formal@none@1@S@In contrast, expression of IL-4, IL-10, and IFN-gamma was strongly inhibited in the transgenic T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s594.5) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005503@unknown@formal@none@1@S@The proliferative deficiency of the transgenic T cells was associated with an increased apoptosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s594.6) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005504@unknown@formal@none@1@S@These results point out the involvement of NF-kappa B/Rel family proteins in growth signaling pathways by either regulating proteins involved in the IL-2 signaling or by functionally interfering with the cell cycle progression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "point") (:form . "point") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 182)\n  (:start . 170) (:id . 68))\n ((:tag . "VBG") (:stem . "interfere") (:form . "interfering") (:end . 194)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 208) (:start . 204)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 226)\n  (:start . 215) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x594.7.1) (:span 106 112 164 166)))\n (:hscopes ((:id . :x594.7.1) (:span 106 226)))\n (:identifiers (:sid . :s594.7) (:did . :|10352258|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005505@unknown@formal@none@1@S@CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.@(((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "lamina") (:form . "lamina") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "propria") (:form . "propria") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 151) (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x595.1.1) (:span 108 115)))\n (:nscopes ((:id . :x595.1.1) (:span 108 151)))\n (:identifiers (:sid . :s595.1) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005506@unknown@formal@none@1@S@The pathways leading to activation in lamina propria (LP) T cells are different from peripheral T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lamina") (:form . "lamina") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "propria") (:form . "propria") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LP") (:form . "LP") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s595.2) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005507@unknown@formal@none@1@S@LP T cells exhibit enhanced IL-2 secretion when activated through the CD2 pathway.@(((:tag . "NNP") (:stem . "LP") (:form . "LP") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s595.3) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005508@unknown@formal@none@1@S@Coligation of CD28 leads to synergistic enhancement of IL-2 secretion.@(((:tag . "NNP") (:stem . "Coligation") (:form . "Coligation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s595.4) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005510@unknown@formal@none@1@S@This study characterized molecular events involved in CD28 costimulation of IL-2 production in LP mononuclear cells (LPMC).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LP") (:form . "LP") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPMC") (:form . "LPMC") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s595.6) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005511@unknown@formal@none@1@S@LPMC exhibited increased IL-2 production in response to CD28 costimulation, compared with cells activated through CD2 alone.@(((:tag . "NNP") (:stem . "LPMC") (:form . "LPMC") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s595.7) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005512@unknown@formal@none@1@S@IL-2 secretion was paralleled by increased expression of IL-2 mRNA, resulting from enhanced IL-2 mRNA stability.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "parallel") (:form . "paralleled") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s595.8) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005513@unknown@formal@none@1@S@In contrast to transcriptional activation in PBMC, EMSA revealed that CD28 coligation of CD2-activated LPMC does not result in increased binding of trans-factors to the CD28RE, nor did Western blots detect changes in I-kappaBalpha or I-kappaBbeta levels following CD28 coligation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 30) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "coligation") (:form . "coligation") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd2-activated") (:form . "CD2-activated")\n  (:end . 102) (:start . 89) (:id . 56))\n ((:tag . "NNP") (:stem . "LPMC") (:form . "LPMC") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "trans-factor") (:form . "trans-factors")\n  (:end . 161) (:start . 148) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cd28re") (:form . "CD28RE") (:end . 175)\n  (:start . 169) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 69))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 192)\n  (:start . 185) (:id . 72))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 198)\n  (:start . 193) (:id . 73))\n ((:tag . "VBP") (:stem . "detect") (:form . "detect") (:end . 205)\n  (:start . 199) (:id . 74))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 213)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "I-kappaBalpha") (:form . "I-kappaBalpha")\n  (:end . 230) (:start . 217) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "I-kappaBbeta") (:form . "I-kappaBbeta")\n  (:end . 246) (:start . 234) (:id . 79))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 253)\n  (:start . 247) (:id . 80))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 263)\n  (:start . 254) (:id . 81))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 268) (:start . 264)\n  (:id . 82))\n ((:tag . "NN") (:stem . "coligation") (:form . "coligation") (:end . 279)\n  (:start . 269) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x595.9.1) (:span 177 180))\n  ((:id . :x595.9.2) (:span 113 116)))\n (:nscopes ((:id . :x595.9.1) (:span 177 279))\n  ((:id . :x595.9.2) (:span 113 175)))\n (:identifiers (:sid . :s595.9) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005514@unknown@formal@none@1@S@Furthermore, CD28 coligation fails to enhance IL-2 promoter-reporter or RE/AP construct expression in CD2-activated LPMC.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "coligation") (:form . "coligation") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter-reporter") (:form . "promoter-reporter")\n  (:end . 68) (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RE/AP") (:form . "RE/AP") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd2-activated") (:form . "CD2-activated")\n  (:end . 115) (:start . 102) (:id . 56))\n ((:tag . "NNP") (:stem . "LPMC") (:form . "LPMC") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x595.10.1) (:span 29 34)))\n (:nscopes ((:id . :x595.10.1) (:span 29 120)))\n (:identifiers (:sid . :s595.10) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005515@unknown@formal@none@1@S@The results reported herein indicate that the molecular mechanisms involved in CD28 cosignaling and regulation of IL-2 secretion in LP T cells are unique to that compartment and differ from those seen in peripheral blood T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "herein") (:form . "herein") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cosignaling") (:form . "cosignaling") (:end . 95)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LP") (:form . "LP") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 173)\n  (:start . 162) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 195)\n  (:start . 190) (:id . 72))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 214)\n  (:start . 204) (:id . 75))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 220)\n  (:start . 215) (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 222) (:start . 221)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 228)\n  (:start . 223) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x595.11.1) (:span 28 41)))\n (:hscopes ((:id . :x595.11.1) (:span 28 228)))\n (:identifiers (:sid . :s595.11) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005516@unknown@formal@none@1@S@These observations suggest a biological significance for different mechanisms of IL-2 activation in initiation and maintenance of the cytokine repertoire found in the mucosa.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 110)\n  (:start . 100) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 126)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 142)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "repertoire") (:form . "repertoire") (:end . 153)\n  (:start . 143) (:id . 61))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 159)\n  (:start . 154) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mucosa") (:form . "mucosa") (:end . 173)\n  (:start . 167) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x595.12.1) (:span 19 26)))\n (:hscopes ((:id . :x595.12.1) (:span 19 173)))\n (:identifiers (:sid . :s595.12) (:did . :|10352279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005517@unknown@formal@none@1@S@Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.@(((:tag . "NN") (:stem . "repression") (:form . "Repression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Aiolos") (:form . "Aiolos") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s596.1) (:did . :|10357820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005518@unknown@formal@none@1@S@Here we show that the lymphoid lineage-determining factors Ikaros and Aiolos can function as strong transcriptional repressors.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "lineage-determining")\n  (:form . "lineage-determining") (:end . 50) (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Aiolos") (:form . "Aiolos") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 115) (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "repressor") (:form . "repressors") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s596.2) (:did . :|10357820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005520@unknown@formal@none@1@S@Repression by Ikaros proteins correlates with hypo-acetylation of core histones at promoter sites and is relieved by histone deacetylase inhibitors.@(((:tag . "NN") (:stem . "repression") (:form . "Repression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypo-acetylation") (:form . "hypo-acetylation")\n  (:end . 62) (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "histone") (:form . "histones") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "relieve") (:form . "relieved") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 136)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s596.4) (:did . :|10357820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005521@unknown@formal@none@1@S@Consistent with these findings, Ikaros and its repression domains can interact in vivo and in vitro with the mSin3 family of co-repressors which bind to histone deacetylases.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "msin3") (:form . "mSin3") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "co-repressor") (:form . "co-repressors")\n  (:end . 138) (:start . 125) (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . "NNS") (:stem . "deacetylas") (:form . "deacetylases") (:end . 173)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s596.5) (:did . :|10357820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005522@unknown@formal@none@1@S@Based on these and our recent findings of associations between Ikaros and Mi-2-HDAC, we propose that Ikaros family members modulate gene expression during lymphocyte development by recruiting distinct histone deacetylase complexes to specific promoters.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "association") (:form . "associations") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Mi-2-HDAC") (:form . "Mi-2-HDAC") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ikaros") (:form . "Ikaros") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 154)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 177)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "recruit") (:form . "recruiting") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 200)\n  (:start . 192) (:id . 70))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 208)\n  (:start . 201) (:id . 71))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 220)\n  (:start . 209) (:id . 72))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 230)\n  (:start . 221) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 233) (:start . 231)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 242)\n  (:start . 234) (:id . 75))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 252)\n  (:start . 243) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x596.6.1) (:span 88 95)))\n (:hscopes ((:id . :x596.6.1) (:span 88 252)))\n (:identifiers (:sid . :s596.6) (:did . :|10357820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005523@unknown@formal@none@1@S@New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation.@(((:tag . "JJ") (:stem . "new") (:form . "New") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "JJ") (:stem . "il-2-dependent") (:form . "IL-2-dependent")\n  (:end . 58) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 72) (:start . 59) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 85)\n  (:start . 77) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 96) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s597.1) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005524@unknown@formal@none@1@S@We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "undecylprodigiosin") (:form . "undecylprodigiosin")\n  (:end . 56) (:start . 38) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "up") (:form . "UP") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 99) (:start . 86) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s597.2) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005525@unknown@formal@none@1@S@We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "analogue") (:form . "analogue") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "up") (:form . "UP") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PNU156804") (:form . "PNU156804") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 96) (:start . 91)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "favorable") (:form . "favorable") (:end . 113)\n  (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "up") (:form . "UP") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 146)\n  (:start . 142) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s597.3) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005526@unknown@formal@none@1@S@We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 89) (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "up") (:form . "UP") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 142) (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mid-late") (:form . "mid-late") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 172)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 207)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cyclin") (:form . "cyclins") (:end . 218)\n  (:start . 211) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 223) (:start . 220)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 240) (:start . 224) (:id . 80))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 248)\n  (:start . 241) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 252) (:start . 249)\n  (:id . 82))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 267) (:start . 253) (:id . 83))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 283) (:start . 268) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 284) (:start . 283)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s597.4) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005527@unknown@formal@none@1@S@In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 64) (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha-") (:form . "alpha-") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gamma-chain") (:form . "gamma-chains") (:end . 126)\n  (:start . 114) (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "JJ") (:stem . "il-2-dependent") (:form . "IL-2-dependent")\n  (:end . 154) (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 175) (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x597.5.1) (:span 41 44)))\n (:nscopes ((:id . :x597.5.1) (:span 41 126)))\n (:identifiers (:sid . :s597.5) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005528@unknown@formal@none@1@S@We have investigated several molecular pathways that are known to be activated by IL-2 in T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s597.6) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005530@unknown@formal@none@1@S@On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PNU156804") (:form . "PNU156804") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s597.8) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005531@unknown@formal@none@1@S@PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta.@(((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "NNP") (:stem . "B-beta") (:form . "B-beta") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s597.9) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005532@unknown@formal@none@1@S@PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes.@(((:tag . "NN") (:stem . "pnu156804") (:form . "PNU156804") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 141)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 163) (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 180)\n  (:start . 169) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x597.10.1) (:span 67 70)))\n (:nscopes ((:id . :x597.10.1) (:span 67 117)))\n (:identifiers (:sid . :s597.10) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005533@unknown@formal@none@1@S@We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prodigiosin") (:form . "prodigiosin") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 61) (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 181) (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 207)\n  (:start . 196) (:id . 72))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 216)\n  (:start . 211) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 217) (:start . 216)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 77))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 231)\n  (:start . 222) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s597.11) (:did . :|10358154|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005534@unknown@formal@none@1@S@IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells.@(((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s598.1) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005535@unknown@formal@none@1@S@IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified.@(((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 114) (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 185)\n  (:start . 179) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 191)\n  (:start . 186) (:id . 70))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 212)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s598.2) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005536@unknown@formal@none@1@S@To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "clarify") (:form . "clarify") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "set") (:form . "set") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 81)\n  (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 100)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "contrast") (:form . "contrasting") (:end . 131)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "il-12-") (:form . "IL-12-") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ifn-alpha-inducible")\n  (:form . "IFN-alpha-inducible") (:end . 162) (:start . 143) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s598.3) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005537@unknown@formal@none@1@S@We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MIP-1alpha") (:form . "MIP-1alpha") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MIP-1beta") (:form . "MIP-1beta") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-1RA") (:form . "IL-1RA") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s598.4) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005538@unknown@formal@none@1@S@IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses.@(((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 24) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s598.5) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005540@unknown@formal@none@1@S@We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 60)\n  (:start . 54) (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 73)\n  (:start . 65) (:id . 56))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 84)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 101)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 114)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x598.7.1) (:span 61 64)))\n (:nscopes ((:id . :x598.7.1) (:span 51 125)))\n (:identifiers (:sid . :s598.7) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005541@unknown@formal@none@1@S@Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 43) (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x598.8.1) (:span 91 94)))\n (:nscopes ((:id . :x598.8.1) (:span 91 94)))\n (:identifiers (:sid . :s598.8) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005542@unknown@formal@none@1@S@The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "way") (:form . "ways") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s598.9) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005543@unknown@formal@none@1@S@First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "STAT4") (:form . "STAT4") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "il-12-dependent") (:form . "IL-12-dependent")\n  (:end . 49) (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 65) (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "RB") (:stem . "second") (:form . "second") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 161) (:start . 156)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s598.10) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005544@unknown@formal@none@1@S@In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 38) (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "il-4-stimulated") (:form . "IL-4-stimulated")\n  (:end . 76) (:start . 61) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "JJ") (:stem . "il-12-dependent") (:form . "IL-12-dependent")\n  (:end . 122) (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 136) (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x598.11.1) (:span 97 100))\n  ((:id . :x598.11.2) (:span 22 24)))\n (:nscopes ((:id . :x598.11.1) (:span 97 145))\n  ((:id . :x598.11.2) (:span 22 82)))\n (:identifiers (:sid . :s598.11) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005545@unknown@formal@none@1@S@Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "contributor") (:form . "contributor") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "speculate") (:form . "speculate") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "irf-1-/-") (:form . "IRF-1-/-") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 142)\n  (:start . 138) (:id . 65))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 164)\n  (:start . 152) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 173) (:start . 169)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 189)\n  (:start . 182) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 197) (:start . 193)\n  (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 211) (:start . 198) (:id . 78))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 218)\n  (:start . 212) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x598.12.2) (:span 143 148))\n  ((:id . :x598.12.3) (:span 76 85)) ((:id . :x598.12.4) (:span 17 20)))\n (:ncues ((:id . :x598.12.1) (:span 182 189)))\n (:hscopes ((:id . :x598.12.2) (:span 143 218))\n  ((:id . :x598.12.3) (:span 76 218)) ((:id . :x598.12.4) (:span 17 67)))\n (:nscopes ((:id . :x598.12.1) (:span 182 218)))\n (:identifiers (:sid . :s598.12) (:did . :|10358173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005546@unknown@formal@none@1@S@Transcriptional regulation of T lymphocyte development and function.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s599.1) (:did . :|10358756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005547@unknown@formal@none@1@S@The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "JJ") (:stem . "cell-surface") (:form . "cell-surface") (:end . 134)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 144)\n  (:start . 135) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 159) (:start . 146) (:id . 62))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 169)\n  (:start . 160) (:id . 63))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 179)\n  (:start . 170) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 192)\n  (:start . 185) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 206) (:start . 193) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 214)\n  (:start . 207) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s599.2) (:did . :|10358756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005548@unknown@formal@none@1@S@Since 1988, several families of functionally important T cell transcription factors have been identified.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1988") (:form . "1988") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s599.3) (:did . :|10358756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005550@unknown@formal@none@1@S@In this review, we summarize our current understanding of the transcriptional regulation of T cell development and function with particular emphasis on the results of recent gene targeting and transgenic experiments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "summarize") (:form . "summarize") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 77) (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "emphasis") (:form . "emphasis") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 173)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "targeting") (:form . "targeting") (:end . 188)\n  (:start . 179) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 203)\n  (:start . 193) (:id . 72))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 215)\n  (:start . 204) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s599.5) (:did . :|10358756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005551@unknown@formal@none@1@S@In addition to increasing our understanding of the molecular pathways that regulate T cell development and function, these results have suggested novel targets for genetic and pharmacological manipulation of T cell immunity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "pharmacological") (:form . "pharmacological")\n  (:end . 191) (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "manipulation") (:form . "manipulation") (:end . 204)\n  (:start . 192) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 209) (:start . 208)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 214) (:start . 210)\n  (:id . 73))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 223)\n  (:start . 215) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x599.6.1) (:span 136 145)))\n (:hscopes ((:id . :x599.6.1) (:span 136 223)))\n (:identifiers (:sid . :s599.6) (:did . :|10358756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005552@unknown@formal@none@1@S@Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "yy1") (:form . "YY1") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "oct1") (:form . "Oct1") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "downregulate") (:form . "downregulates")\n  (:end . 61) (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s600.1) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005553@unknown@formal@none@1@S@BACKGROUND: IL-5 controls development of eosinophilia and has been shown to be involved in the pathogenesis of allergic diseases.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "eosinophilia") (:form . "eosinophilia") (:end . 53)\n  (:start . 41) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s600.2) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005554@unknown@formal@none@1@S@In both atopic and nonatopic asthma, elevated IL-5 has been detected in peripheral blood and the airways.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nonatopic") (:form . "nonatopic") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "airway") (:form . "airways") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s600.3) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005555@unknown@formal@none@1@S@IL-5 is produced mainly by activated T cells, and its expression is regulated at the transcriptional level.@(((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s600.4) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005556@unknown@formal@none@1@S@OBJECTIVE: This study focuses on the functional analysis of the human IL-5 (hIL-5) promoter and characterization of cis -regulatory elements and transcription factors involved in the suppression of IL-5 transcription in T cells.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "This") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "focus") (:form . "focuses") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hil-5") (:form . "hIL-5") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 112) (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "cis") (:stem . "cis") (:form . "cis") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "-regulatory") (:form . "-regulatory") (:end . 131)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 158) (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 166)\n  (:start . 159) (:id . 67))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 175)\n  (:start . 167) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 194)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 202) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 216) (:start . 203) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 221) (:start . 220)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 227)\n  (:start . 222) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s600.5) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005557@unknown@formal@none@1@S@METHODS: Methods used in this study include DNase I footprint assays, electrophoretic mobility shift assays, and functional analysis by mammalian cell transfection involving deletion analysis and site-directed mutagenesis.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 85) (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 163)\n  (:start . 151) (:id . 66))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "site-directed") (:form . "site-directed")\n  (:end . 209) (:start . 196) (:id . 71))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 221)\n  (:start . 210) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s600.6) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005558@unknown@formal@none@1@S@RESULTS: We identified 5 protein binding regions (BRs) located within the proximal hIL-5 promoter.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BR") (:form . "BRs") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "hil-5") (:form . "hIL-5") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s600.7) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005560@unknown@formal@none@1@S@Two of these regions, BR3 and BR4 located at positions -102 to -73, have not previously been described as regulators of IL-5 expression in T cells.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "br3") (:form . "BR3") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "br4") (:form . "BR4") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 41)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 54)\n  (:start . 45) (:id . 52))\n ((:tag . "CD") (:stem . "-102") (:form . "-102") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-73") (:form . "-73") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 72) (:start . 68)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 87)\n  (:start . 77) (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 92) (:start . 88)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 102)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 116)\n  (:start . 106) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 140) (:start . 139)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x600.9.1) (:span 73 76)))\n (:nscopes ((:id . :x600.9.1) (:span 0 146)))\n (:identifiers (:sid . :s600.9) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005561@unknown@formal@none@1@S@We show that the BR3 sequence contains a novel negative regulatory element located at positions -90 to -79 of the hIL-5 promoter, which binds Oct1, octamer-like, and YY1 nuclear factors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "br3") (:form . "BR3") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "CD") (:stem . "-90") (:form . "-90") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-79") (:form . "-79") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hil-5") (:form . "hIL-5") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "oct1") (:form . "Oct1") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "octamer-like") (:form . "octamer-like") (:end . 160)\n  (:start . 148) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "yy1") (:form . "YY1") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 177)\n  (:start . 170) (:id . 73))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 185)\n  (:start . 178) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s600.10) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005562@unknown@formal@none@1@S@Substitution mutations, which abolished binding of these proteins to the BR3 sequence, significantly increased hIL-5 promoter activity in activated T cells.@(((:tag . "NN") (:stem . "substitution") (:form . "Substitution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "br3") (:form . "BR3") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 100) (:start . 87) (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "hil-5") (:form . "hIL-5") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 149) (:start . 148)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s600.11) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005563@unknown@formal@none@1@S@CONCLUSION: We suggest that Oct1, YY1, and octamer-like factors binding to the -90/-79 sequence within the proximal IL-5 promoter are involved in suppression of IL-5 transcription in T cells.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Oct1") (:form . "Oct1") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "YY1") (:form . "YY1") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "octamer-like") (:form . "octamer-like") (:end . 55)\n  (:start . 43) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-90/-79") (:form . "-90/-79") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 142)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 157)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 190)\n  (:start . 185) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x600.12.1) (:span 15 22)))\n (:hscopes ((:id . :x600.12.1) (:span 15 190)))\n (:identifiers (:sid . :s600.12) (:did . :|10359895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005564@unknown@formal@none@1@S@Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 57)\n  (:start . 50) (:id . 47))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 62) (:start . 58)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "antagonism") (:form . "antagonism") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s601.1) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005565@unknown@formal@none@1@S@Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood.@(((:tag . "JJ") (:stem . "malignant") (:form . "Malignant") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 50)\n  (:start . 42) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 71) (:start . 56) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 98)\n  (:start . 88) (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 126)\n  (:start . 116) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x601.2.1) (:span 112 115)))\n (:nscopes ((:id . :x601.2.1) (:span 76 126)))\n (:identifiers (:sid . :s601.2) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005566@unknown@formal@none@1@S@PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hematopoietic-specific")\n  (:form . "hematopoietic-specific") (:end . 32) (:start . 10) (:id . 45))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 97)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s601.3) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005567@unknown@formal@none@1@S@PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 35)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transgenesis") (:form . "transgenesis") (:end . 129)\n  (:start . 117) (:id . 61))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NNS") (:stem . "erythroleukemia") (:form . "erythroleukemias")\n  (:end . 153) (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 161)\n  (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s601.4) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005568@unknown@formal@none@1@S@Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation.@(((:tag . "NNP") (:stem . "Restoration") (:form . "Restoration") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 68) (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MEL") (:form . "MEL") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 162)\n  (:start . 153) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 178) (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x601.5.1) (:span 122 137)))\n (:hscopes ((:id . :x601.5.1) (:span 122 178)))\n (:identifiers (:sid . :s601.5) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005570@unknown@formal@none@1@S@We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 123) (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s601.7) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005571@unknown@formal@none@1@S@Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins.@(((:tag . "NNP") (:stem . "Interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 63)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s601.8) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005572@unknown@formal@none@1@S@PU.1 represses GATA-1-mediated transcriptional activation.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "gata-1-mediated") (:form . "GATA-1-mediated")\n  (:end . 30) (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 46) (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s601.9) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005573@unknown@formal@none@1@S@Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 40) (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 151) (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MEL") (:form . "MEL") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s601.10) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005574@unknown@formal@none@1@S@We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Xenopus") (:form . "Xenopus") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 101) (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 127)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s601.11) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005575@unknown@formal@none@1@S@Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "introduction") (:form . "introduction") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MEL") (:form . "MEL") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "xenopus") (:form . "Xenopus") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "explant") (:form . "explants") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "VBZ") (:stem . "relieve") (:form . "relieves") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 144) (:start . 129) (:id . 62))\n ((:tag . "VBN") (:stem . "impose") (:form . "imposed") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 160) (:start . 156)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s601.12) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005576@unknown@formal@none@1@S@Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stoichiometry") (:form . "stoichiometry")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 67)\n  (:start . 56) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "oppose") (:form . "opposing") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 131)\n  (:start . 120) (:id . 59))\n ((:tag . "VBG") (:stem . "govern") (:form . "governing") (:end . 141)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 161)\n  (:start . 155) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 177) (:start . 162) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 191)\n  (:start . 182) (:id . 66))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 206) (:start . 192) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x601.13.1) (:span 103 106))\n  ((:id . :x601.13.2) (:span 12 25)))\n (:hscopes ((:id . :x601.13.1) (:span 103 206))\n  ((:id . :x601.13.2) (:span 12 206)))\n (:identifiers (:sid . :s601.13) (:did . :|10364157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005577@unknown@formal@none@1@S@Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development.@(((:tag . "JJ") (:stem . "potent") (:form . "Potent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "attenuation") (:form . "attenuation") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "live-hiv-1") (:form . "live-HIV-1") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gain") (:form . "gain") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "proteolysis-resistant")\n  (:form . "proteolysis-resistant") (:end . 78) (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IkappaB-alphaS32/36A")\n  (:form . "IkappaB-alphaS32/36A") (:end . 123) (:start . 103) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 145)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "vaccine") (:form . "vaccine") (:end . 157)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 169)\n  (:start . 158) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s602.1) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005578@unknown@formal@none@1@S@Live-attenuated human immunodeficiency viruses (HIVs) are candidates for Acquired Immunodeficiency Syndrome (AIDS) vaccine.@(((:tag . "JJ") (:stem . "live-attenuated") (:form . "Live-attenuated")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 21) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 38) (:start . 22) (:id . 44))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 46)\n  (:start . 39) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 46))\n ((:tag . "NNPS") (:stem . "HIV") (:form . "HIVs") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "acquire") (:form . "Acquired") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NNP") (:stem . "Immunodeficiency") (:form . "Immunodeficiency")\n  (:end . 98) (:start . 82) (:id . 53))\n ((:tag . "NNP") (:stem . "Syndrome") (:form . "Syndrome") (:end . 107)\n  (:start . 99) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 113) (:start . 109)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "vaccine") (:form . "vaccine") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s602.2) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005580@unknown@formal@none@1@S@Regrettably, recent evidence suggests that loss-of-function alone is not always sufficient to prevent the emergence of virulent mutants.@(((:tag . "RB") (:stem . "regrettably") (:form . "Regrettably") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 59) (:start . 43) (:id . 48))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "RB") (:stem . "always") (:form . "always") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "virulent") (:form . "virulent") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x602.4.1) (:span 29 37)))\n (:hscopes ((:id . :x602.4.1) (:span 29 135)))\n (:identifiers (:sid . :s602.4) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005581@unknown@formal@none@1@S@New strategies that attenuate via mechanisms distinct from loss-of-function are needed for enhancing the safety phenotype of viral genome.@(((:tag . "JJ") (:stem . "new") (:form . "New") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "attenuate") (:form . "attenuate") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 75) (:start . 59) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 86) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "safety") (:form . "safety") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s602.5) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005582@unknown@formal@none@1@S@Here, we propose gain-of-function to be used simultaneously with loss-of-function as a novel approach for attenuating HIV-1.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "gain-of-function") (:form . "gain-of-function")\n  (:end . 33) (:start . 17) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 59) (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 81) (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "attenuate") (:form . "attenuating") (:end . 117)\n  (:start . 106) (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s602.6) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005583@unknown@formal@none@1@S@We have constructed an HIV-1 genome carrying the cDNA of a proteolysis-resistant nuclear factor-kappaB inhibitor (IkappaB-alphaS32/36A) in the nef region.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proteolysis-resistant")\n  (:form . "proteolysis-resistant") (:end . 80) (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 102) (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaB-alphaS32/36A")\n  (:form . "IkappaB-alphaS32/36A") (:end . 134) (:start . 114) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s602.7) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005584@unknown@formal@none@1@S@HIV-1 expressing IkappaB-alphaS32/36A down-regulates viral expression and is highly attenuated in both Jurkat and peripheral blood mononuclear cells.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaB-alphaS32/36A")\n  (:form . "IkappaB-alphaS32/36A") (:end . 37) (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "down-regulate") (:form . "down-regulates")\n  (:end . 52) (:start . 38) (:id . 45))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 58) (:start . 53)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 49))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 83)\n  (:start . 77) (:id . 50))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 94)\n  (:start . 84) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 102) (:start . 98)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 109)\n  (:start . 103) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 124)\n  (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 130)\n  (:start . 125) (:id . 57))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 142)\n  (:start . 131) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s602.8) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005585@unknown@formal@none@1@S@We provide formal proof that the phenotypic and attenuating characteristics of IkappaB-alphaS32/36A permit its stable maintenance in a live, replicating HIV-1 despite 180 days of forced ex vivo passaging in tissue culture.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "formal") (:form . "formal") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "proof") (:form . "proof") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "attenuate") (:form . "attenuating") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IkappaB-alphaS32/36A")\n  (:form . "IkappaB-alphaS32/36A") (:end . 99) (:start . 79) (:id . 53))\n ((:tag . "VBP") (:stem . "permit") (:form . "permit") (:end . 106)\n  (:start . 100) (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 117)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 129)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 59))\n ((:tag . "NN") (:stem . "live") (:form . "live") (:end . 139) (:start . 135)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "replicate") (:form . "replicating") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 158)\n  (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "CD") (:stem . "180") (:form . "180") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "force") (:form . "forced") (:end . 185)\n  (:start . 179) (:id . 68))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 188) (:start . 186)\n  (:id . 69))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 193) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "passaging") (:form . "passaging") (:end . 203)\n  (:start . 194) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 213)\n  (:start . 207) (:id . 73))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 221)\n  (:start . 214) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s602.9) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005586@unknown@formal@none@1@S@As compared with other open-reading frames embedded into HIV/SIV genome, this degree of stability is unprecedented.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "open-reading") (:form . "open-reading") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBN") (:stem . "embed") (:form . "embedded") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV/SIV") (:form . "HIV/SIV") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unprecedented") (:form . "unprecedented")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s602.10) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005587@unknown@formal@none@1@S@Thus, IkappaB-alphaS32/36A offers proof-of-principle that artifactually gained functions, when used to attenuate the replication of live HIV-1, can be stable.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaB-alphaS32/36A")\n  (:form . "IkappaB-alphaS32/36A") (:end . 26) (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "offer") (:form . "offers") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "proof-of-principle") (:form . "proof-of-principle")\n  (:end . 52) (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 47))\n ((:tag . "RB") (:stem . "artifactually") (:form . "artifactually")\n  (:end . 71) (:start . 58) (:id . 48))\n ((:tag . "VBN") (:stem . "gain") (:form . "gained") (:end . 78) (:start . 72)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 88)\n  (:start . 79) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 94) (:start . 90)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 99) (:start . 95)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "VB") (:stem . "attenuate") (:form . "attenuate") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 128)\n  (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "live") (:form . "live") (:end . 136) (:start . 132)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 142)\n  (:start . 137) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s602.11) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005588@unknown@formal@none@1@S@These findings illustrate gain-of-function as a feasible strategy for developing safer live-attenuated HIVs to be tested as candidates for AIDS vaccine.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "illustrate") (:form . "illustrate") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "gain-of-function") (:form . "gain-of-function")\n  (:end . 42) (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "feasible") (:form . "feasible") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "JJR") (:stem . "safe") (:form . "safer") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "live-attenuated") (:form . "live-attenuated")\n  (:end . 102) (:start . 87) (:id . 53))\n ((:tag . "NNS") (:stem . "hiv") (:form . "HIVs") (:end . 107) (:start . 103)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 120)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "vaccine") (:form . "vaccine") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s602.12) (:did . :|10364191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005590@unknown@formal@none@1@S@Although many functions of human alveolar macrophages are altered compared with their precursor cell, the blood monocyte (monocyte), the reason(s) for these functional changes have not been determined.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 85)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "reason(s)") (:form . "reason(s)") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 167)\n  (:start . 157) (:id . 68))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 189) (:start . 185)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 200)\n  (:start . 190) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x603.2.1) (:span 181 184)))\n (:nscopes ((:id . :x603.2.1) (:span 133 200)))\n (:identifiers (:sid . :s603.2) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005591@unknown@formal@none@1@S@We recently reported that human alveolar macrophages do not express AP-1 DNA binding activity (Monick, M. M., Carter, A. B., Gudmundsson, G., Geist, L. J., and Hunninghake, G. W. (1998) Am. J. Physiol. 275, L389-L397).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "VBP") (:stem . "do") (:form . 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5005592@unknown@formal@none@1@S@To determine why alveolar macrophages do not express AP-1 DNA binding activity, we first showed that there was not a decrease in expression of the FOS and JUN proteins that make up the AP-1 complex.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 95) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "JUN") (:form . "JUN") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 177) (:start . 173)\n  (:id . 73))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 180) (:start . 178)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 189) (:start . 185)\n  (:id . 76))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 197)\n  (:start . 190) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x603.4.1) (:span 111 114))\n  ((:id . :x603.4.2) (:span 41 44)))\n (:nscopes ((:id . :x603.4.1) (:span 111 197))\n  ((:id . :x603.4.2) (:span 41 78)))\n (:identifiers (:sid . :s603.4) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005593@unknown@formal@none@1@S@There was, however, a significant difference in the amounts of the nuclear protein, REF-1 (which regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins), in alveolar macrophages compared with monocytes.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 33)\n  (:start . 22) (:id . 48))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ref-1") (:form . "REF-1") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 96) (:start . 91)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 106)\n  (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 145)\n  (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 152)\n  (:start . 146) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "FOS") (:form . "FOS") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "JUN") (:form . "JUN") (:end . 167) (:start . 164)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 176)\n  (:start . 168) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 190)\n  (:start . 182) (:id . 78))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 202)\n  (:start . 191) (:id . 79))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 211)\n  (:start . 203) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 216) (:start . 212)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 226)\n  (:start . 217) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s603.5) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005594@unknown@formal@none@1@S@In addition, in vitro differentiation of monocytes to a macrophage-like cell resulted in decreased amounts of REF-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 37) (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 71) (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ref-1") (:form . "REF-1") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s603.6) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005595@unknown@formal@none@1@S@Finally, addition of REF-1 from activated monocytes to alveolar macrophage nuclear proteins resulted in a marked increase in AP-1 DNA binding.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ref-1") (:form . "REF-1") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s603.7) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005596@unknown@formal@none@1@S@These studies strongly suggest that the process of differentiation of monocytes into alveolar macrophages is associated with a loss of REF-1 and AP-1 activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 66) (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 119)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ref-1") (:form . "REF-1") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x603.8.1) (:span 23 30)))\n (:hscopes ((:id . :x603.8.1) (:span 23 158)))\n (:identifiers (:sid . :s603.8) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005597@unknown@formal@none@1@S@This observation may explain, in part, some of the functional differences observed for alveolar macrophages compared with monocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 73)\n  (:start . 62) (:id . 54))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x603.9.1) (:span 17 20)))\n (:hscopes ((:id . :x603.9.1) (:span 17 131)))\n (:identifiers (:sid . :s603.9) (:did . :|10364260|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005598@unknown@formal@none@1@S@A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria [see comments]@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "oct-1") (:form . "OCT-1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s604.1) (:did . :|10369255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005600@unknown@formal@none@1@S@Through systematic DNA footprinting of the TNF (encoding tumour necrosis factor, TNF) promoter region, we have identified a single nucleotide polymorphism (SNP) that causes the helix-turn-helix transcription factor OCT-1 to bind to a novel region of complex protein-DNA interactions and alters gene expression in human monocytes.@(((:tag . "IN") (:stem . "through") (:form . "Through") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "systematic") (:form . "systematic") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 35)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF") (:form . 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"gene") (:end . 298) (:start . 294)\n  (:id . 89))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 309)\n  (:start . 299) (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 312) (:start . 310)\n  (:id . 91))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 318)\n  (:start . 313) (:id . 92))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 328)\n  (:start . 319) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 329) (:start . 328)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s604.3) (:did . :|10369255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005601@unknown@formal@none@1@S@The OCT-1-binding genotype, found in approximately 5% of Africans, is associated with fourfold increased susceptibility to cerebral malaria in large case-control studies of West African and East African populations, after correction for other known TNF polymorphisms and linked HLA alleles.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "oct-1-binding") (:form . "OCT-1-binding")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "genotype") (:form . "genotype") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "African") (:form . "Africans") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "RB") (:stem . "fourfold") (:form . "fourfold") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 119) (:start . 105) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cerebral") (:form . "cerebral") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "JJ") (:stem . "case-control") (:form . "case-control") (:end . 161)\n  (:start . 149) (:id . 65))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "west") (:form . "West") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "east") (:form . "East") (:end . 194) (:start . 190)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 202)\n  (:start . 195) (:id . 72))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 214)\n  (:start . 203) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 74))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 221)\n  (:start . 216) (:id . 75))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 232)\n  (:start . 222) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 236) (:start . 233)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 242)\n  (:start . 237) (:id . 78))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 248)\n  (:start . 243) (:id . 79))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 252) (:start . 249)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "polymorphism") (:form . "polymorphisms")\n  (:end . 266) (:start . 253) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 270) (:start . 267)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 277)\n  (:start . 271) (:id . 83))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 281) (:start . 278)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 289)\n  (:start . 282) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s604.4) (:did . :|10369255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005602@unknown@formal@none@1@S@Novel therapies for inflammatory bowel disease.@(((:tag . "JJ") (:stem . "novel") (:form . "Novel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "therapy") (:form . "therapies") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "bowel") (:form . "bowel") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s605.1) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005603@unknown@formal@none@1@S@Looking back at successes and failures in newer approaches to treating IBD, it is tempting--although still difficult--to draw conclusions about pathogenesis.@(((:tag . "VBG") (:stem . "look") (:form . "Looking") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "back") (:form . "back") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "success") (:form . "successes") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "failure") (:form . "failures") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "new") (:form . "newer") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "treat") (:form . "treating") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NNP") (:stem . "IBD") (:form . "IBD") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tempting–although") (:form . "tempting–although")\n  (:end . 100) (:start . 82) (:id . 57))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "difficult–to") (:form . "difficult–to") (:end . 120)\n  (:start . 107) (:id . 59))\n ((:tag . "VB") (:stem . "draw") (:form . "draw") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "conclusion") (:form . "conclusions") (:end . 137)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 156)\n  (:start . 144) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s605.2) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005604@unknown@formal@none@1@S@When a therapy proves effective, do clinicians truly know how it works?@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBZ") (:stem . "prove") (:form . "proves") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "clinician") (:form . "clinicians") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "RB") (:stem . "truly") (:form . "truly") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "know") (:form . "know") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "work") (:form . "works") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 71) (:start . 70)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s605.3) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005605@unknown@formal@none@1@S@Even with a therapy as specific as anti-TNF antibody, it is not clear if the benefit is attributable to simple binding and clearance of TNF-alpha or to binding on the cell surface and subsequent deletion of the activated macrophage.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-tnf") (:form . "anti-TNF") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "benefit") (:form . "benefit") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 100)\n  (:start . 88) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "clearance") (:form . "clearance") (:end . 132)\n  (:start . 123) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 145)\n  (:start . 136) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 159)\n  (:start . 152) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 73))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 179)\n  (:start . 172) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 194)\n  (:start . 184) (:id . 76))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 203)\n  (:start . 195) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 220)\n  (:start . 211) (:id . 80))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 231)\n  (:start . 221) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x605.4.1) (:span 146 148)) ((:id . :x605.4.2) (:span 70 72))\n  ((:id . :x605.4.3) (:span 60 69)))\n (:hscopes ((:id . :x605.4.1) (:span 101 231))\n  ((:id . :x605.4.2) (:span 70 231)) ((:id . :x605.4.3) (:span 60 231)))\n (:identifiers (:sid . :s605.4) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005606@unknown@formal@none@1@S@When a drug appears to be less effective than preclinical models suggest, can failures in effectiveness from delivery or dosing be differentiated?@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 40)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "preclinical") (:form . "preclinical") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "failure") (:form . "failures") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effectiveness") (:form . "effectiveness")\n  (:end . 103) (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dosing") (:form . "dosing") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 145) (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x605.5.1) (:span 12 19)))\n (:hscopes ((:id . :x605.5.1) (:span 5 72)))\n (:identifiers (:sid . :s605.5) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005607@unknown@formal@none@1@S@The disappointing results of clinical trials with IL-10--so at odds with the prediction of benefit from animal models--bring into question the validity of those models as well as the soundness of design of the clinical trials on which efficacy of IL-10 is judged.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "disappointing") (:form . "disappointing")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "trial") (:form . "trials") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-10–so") (:form . "IL-10–so") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "benefit") (:form . "benefit") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "models–bring") (:form . "models–bring") (:end . 124)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "validity") (:form . "validity") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "soundness") (:form . "soundness") (:end . 192)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 202)\n  (:start . 196) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . "NNS") (:stem . "trial") (:form . "trials") (:end . 225)\n  (:start . 219) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 234)\n  (:start . 229) (:id . 79))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 243)\n  (:start . 235) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 252)\n  (:start . 247) (:id . 82))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 255) (:start . 253)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 262)\n  (:start . 256) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s605.6) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005608@unknown@formal@none@1@S@The variability of response even to the most narrowly targeted agents suggests that these diseases are far more heterogeneous in humans than in their murine counterparts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variability") (:form . "variability") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "narrowly") (:form . "narrowly") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 125) (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "NNS") (:stem . "counterpart") (:form . "counterparts") (:end . 169)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x605.7.1) (:span 70 78)))\n (:hscopes ((:id . :x605.7.1) (:span 70 169)))\n (:identifiers (:sid . :s605.7) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005610@unknown@formal@none@1@S@For the moment, however, the field of pharmacogenetics is embryonic.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "moment") (:form . "moment") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "pharmacogenetic") (:form . "pharmacogenetics")\n  (:end . 54) (:start . 38) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s605.9) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005611@unknown@formal@none@1@S@Challenges in developing new therapeutic strategies include not only identifying novel agents, but also improving the definitions of clinical endpoints and defining efficacy at the biologic level.@(((:tag . "NNS") (:stem . "challenge") (:form . "Challenges") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "improve") (:form . "improving") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "definition") (:form . "definitions") (:end . 129)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "NNS") (:stem . "endpoint") (:form . "endpoints") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "define") (:form . "defining") (:end . 164)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 173)\n  (:start . 165) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 189)\n  (:start . 181) (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 195)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s605.10) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005612@unknown@formal@none@1@S@Only through considered evaluation of clinical evidence may clinicians determine which therapies should remain novelties and which should become an accepted part of the armamentarium.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "clinician") (:form . "clinicians") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "therapy") (:form . "therapies") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 103)\n  (:start . 97) (:id . 54))\n ((:tag . "VB") (:stem . "remain") (:form . "remain") (:end . 110)\n  (:start . 104) (:id . 55))\n ((:tag . "NNS") (:stem . "novelty") (:form . "novelties") (:end . 120)\n  (:start . 111) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 144)\n  (:start . 138) (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "accept") (:form . "accepted") (:end . 156)\n  (:start . 148) (:id . 62))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 161) (:start . 157)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "armamentarium") (:form . "armamentarium")\n  (:end . 182) (:start . 169) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x605.11.1) (:span 131 137))\n  ((:id . :x605.11.2) (:span 97 103)) ((:id . :x605.11.3) (:span 56 59)))\n (:hscopes ((:id . :x605.11.1) (:span 131 182))\n  ((:id . :x605.11.2) (:span 97 120)) ((:id . :x605.11.3) (:span 56 182)))\n (:identifiers (:sid . :s605.11) (:did . :|10372271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005613@unknown@formal@none@1@S@PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells.@(((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 45) (:start . 29) (:id . 45))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 54)\n  (:start . 46) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 68)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 79)\n  (:start . 69) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 111)\n  (:start . 100) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s606.1) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005614@unknown@formal@none@1@S@BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Adhesion") (:form . "Adhesion") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 134) (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s606.2) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005615@unknown@formal@none@1@S@Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation.@(((:tag . "JJR") (:stem . "good") (:form . "Better") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 20) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 72)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plaque") (:form . "plaque") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 131)\n  (:start . 122) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x606.3.1) (:span 80 83)))\n (:hscopes ((:id . :x606.3.1) (:span 80 131)))\n (:identifiers (:sid . :s606.3) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005616@unknown@formal@none@1@S@Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives.@(((:tag . "NNP") (:stem . "Peroxisome") (:form . "Peroxisome") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "proliferator-activated")\n  (:form . "proliferator-activated") (:end . 33) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "receptor-alpha") (:form . "receptor-alpha")\n  (:end . 48) (:start . 34) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 59)\n  (:start . 50) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "fibric") (:form . "fibric") (:end . 174)\n  (:start . 168) (:id . 67))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 191)\n  (:start . 180) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s606.4) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005617@unknown@formal@none@1@S@The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 74)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s606.5) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005618@unknown@formal@none@1@S@METHODS AND RESULTS: Immunohistochemistry revealed that human carotid artery ECs express PPARalpha.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Immunohistochemistry")\n  (:form . "Immunohistochemistry") (:end . 41) (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "carotid") (:form . "carotid") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "artery") (:form . "artery") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s606.6) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005620@unknown@formal@none@1@S@Both PPARalpha activators decreased cytokine-induced VCAM-1 mRNA expression without altering its mRNA half-life.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 52) (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 59)\n  (:start . 53) (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 64) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 83)\n  (:start . 76) (:id . 50))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 92)\n  (:start . 84) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 96) (:start . 93)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 101) (:start . 97)\n  (:id . 53))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 111)\n  (:start . 102) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x606.8.1) (:span 76 83)))\n (:nscopes ((:id . :x606.8.1) (:span 76 111)))\n (:identifiers (:sid . :s606.8) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005621@unknown@formal@none@1@S@Transient transfection of deletional VCAM-1 promoter constructs and electrophoretic mobility shift assays suggest that fenofibrate inhibits VCAM-1 transcription in part by inhibiting NF-kappaB.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "deletional") (:form . "deletional") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 83) (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 92)\n  (:start . 84) (:id . 51))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 98) (:start . 93)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 105)\n  (:start . 99) (:id . 53))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 113)\n  (:start . 106) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 55))\n ((:tag . "NN") (:stem . "fenofibrate") (:form . "fenofibrate") (:end . 130)\n  (:start . 119) (:id . 56))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 139)\n  (:start . 131) (:id . 57))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 146)\n  (:start . 140) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 160) (:start . 147) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 60))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 168) (:start . 164)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 182)\n  (:start . 172) (:id . 63))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 192)\n  (:start . 183) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x606.9.1) (:span 106 113)))\n (:hscopes ((:id . :x606.9.1) (:span 106 192)))\n (:identifiers (:sid . :s606.9) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005622@unknown@formal@none@1@S@Finally, PPARalpha activators significantly reduced adhesion of U937 cells to cultured human ECs.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s606.10) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005623@unknown@formal@none@1@S@CONCLUSIONS: Human ECs express PPARalpha, a potentially important regulator of atherogenesis through its transcriptional control of VCAM-1 gene expression.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNPS") (:stem . "EC") (:form . "ECs") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 120) (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 138)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 154)\n  (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x606.11.1) (:span 44 55)))\n (:hscopes ((:id . :x606.11.1) (:span 44 65)))\n (:identifiers (:sid . :s606.11) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005624@unknown@formal@none@1@S@Such findings also have implications regarding the clinical use of lipid-lowering agents, like fibric acids, which can activate PPARalpha.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "VBG") (:stem . "regard") (:form . "regarding") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lipid-lowering") (:form . "lipid-lowering")\n  (:end . 81) (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fibric") (:form . "fibric") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "NNP") (:stem . "PPARalpha") (:form . "PPARalpha") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s606.12) (:did . :|10377075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005625@unknown@formal@none@1@S@The intracellular parasite Theileria parva protects infected T cells from apoptosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "parasite") (:form . "parasite") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "FW") (:stem . "theileria") (:form . "Theileria") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "FW") (:stem . "parva") (:form . "parva") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s607.1) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005626@unknown@formal@none@1@S@Parasites have evolved a plethora of strategies to ensure their survival.@(((:tag . "NNS") (:stem . "parasite") (:form . "Parasites") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "plethora") (:form . "plethora") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 63)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s607.2) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005627@unknown@formal@none@1@S@The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting and transforming T cells, inducing their continuous proliferation and rendering them metastatic.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "parasite") (:form . "parasite") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "FW") (:stem . "theileria") (:form . "Theileria") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "FW") (:stem . "parva") (:form . "parva") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "secure") (:form . "secures") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "propagation") (:form . "propagation") (:end . 66)\n  (:start . 55) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "spread") (:form . "spreads") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "infect") (:form . "infecting") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 136)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 154)\n  (:start . 146) (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 171)\n  (:start . 161) (:id . 65))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 185) (:start . 172) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "render") (:form . "rendering") (:end . 199)\n  (:start . 190) (:id . 68))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 204) (:start . 200)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "metastatic") (:form . "metastatic") (:end . 215)\n  (:start . 205) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s607.3) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005628@unknown@formal@none@1@S@In previous work, we have shown that the parasite induces constitutive activation of the transcription factor NF-kappaB, by inducing the constitutive degradation of its cytoplasmic inhibitors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "parasite") (:form . "parasite") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 149)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 161)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 180)\n  (:start . 169) (:id . 68))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s607.4) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005630@unknown@formal@none@1@S@Cells that have been transformed by viruses or oncogenes can persist only if they manage to avoid destruction by the apoptotic mechanisms that are activated on transformation and that contribute to maintain cellular homeostasis.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "oncogene") (:form . "oncogenes") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "persist") (:form . "persist") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "manage") (:form . "manage") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "destruction") (:form . "destruction") (:end . 109)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 174) (:start . 160) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 206)\n  (:start . 198) (:id . 73))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 215)\n  (:start . 207) (:id . 74))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 227)\n  (:start . 216) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s607.6) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005631@unknown@formal@none@1@S@We now demonstrate that parasite-induced NF-kappaB activation plays a crucial role in the survival of T. parva-transformed T cells by conveying protection against an apoptotic signal that accompanies parasite-mediated transformation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "parasite-induced") (:form . "parasite-induced")\n  (:end . 40) (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "FW") (:stem . "t.") (:form . "T.") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "parva-transformed") (:form . "parva-transformed")\n  (:end . 122) (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "convey") (:form . "conveying") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 154)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 175)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 182)\n  (:start . 176) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "accompany") (:form . "accompanies") (:end . 199)\n  (:start . 188) (:id . 69))\n ((:tag . "JJ") (:stem . "parasite-mediated") (:form . "parasite-mediated")\n  (:end . 217) (:start . 200) (:id . 70))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 232) (:start . 218) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s607.7) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005632@unknown@formal@none@1@S@Consequently, inhibition of NF-kappaB nuclear translocation and the expression of dominant negative mutant forms of components of the NF-kappaB activation pathway, such as IkappaBalpha or p65, prompt rapid apoptosis of T. parva-transformed T cells.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 154)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 162)\n  (:start . 155) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 184) (:start . 172) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 187) (:start . 185)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 191) (:start . 188)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "prompt") (:form . "prompt") (:end . 199)\n  (:start . 193) (:id . 71))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 205)\n  (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 215)\n  (:start . 206) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 74))\n ((:tag . "FW") (:stem . "t.") (:form . "T.") (:end . 221) (:start . 219)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "parva-transformed") (:form . "parva-transformed")\n  (:end . 239) (:start . 222) (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 241) (:start . 240)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 247)\n  (:start . 242) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s607.8) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005633@unknown@formal@none@1@S@Our findings offer important insights into parasite survival strategies and demonstrate that parasite-induced constitutive NF-kappaB activation is an essential step in maintaining the transformed phenotype of the infected cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "offer") (:form . "offer") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "parasite") (:form . "parasite") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "parasite-induced") (:form . "parasite-induced")\n  (:end . 109) (:start . 93) (:id . 54))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 122)\n  (:start . 110) (:id . 55))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 132)\n  (:start . 123) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 143)\n  (:start . 133) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 159)\n  (:start . 150) (:id . 60))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 164) (:start . 160)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 179)\n  (:start . 168) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 195)\n  (:start . 184) (:id . 65))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 205)\n  (:start . 196) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 221)\n  (:start . 213) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 227)\n  (:start . 222) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s607.9) (:did . :|10377411|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005634@unknown@formal@none@1@S@Downregulation of Wilms' tumor gene (WT1) is not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562.@(((:tag . "NN") (:stem . "downregulation") (:form . "Downregulation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Wilms") (:form . "Wilms") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "prerequisite") (:form . "prerequisite") (:end . 63)\n  (:start . 51) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 77)\n  (:start . 68) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 95) (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 111) (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x608.1.1) (:span 45 48)))\n (:nscopes ((:id . :x608.1.1) (:span 45 142)))\n (:identifiers (:sid . :s608.1) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005635@unknown@formal@none@1@S@The Wilms' tumor gene (WT1) encodes a transcription factor of the zinc finger type.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "Wilms") (:form . "Wilms") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 35)\n  (:start . 28) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 70) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 77)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s608.2) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005636@unknown@formal@none@1@S@A high expression of WT1 has been detected in a range of acute leukemias, and WT1 is downregulated during induced differentiation of some leukemic cell lines.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "WT1") (:form . "WT1") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 72)\n  (:start . 63) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "WT1") (:form . "WT1") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 98) (:start . 85) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 105)\n  (:start . 99) (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 113)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 129) (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s608.3) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005637@unknown@formal@none@1@S@Overexpression of WT1 in some myeloid cell lines confers resistance to differentiation induction.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 86) (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s608.4) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005638@unknown@formal@none@1@S@These observations suggest that a high WT1 expression in hematopoietic cells is incompatible with differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "incompatible") (:form . "incompatible") (:end . 92)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 113) (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x608.5.1) (:span 19 26)))\n (:hscopes ((:id . :x608.5.1) (:span 19 113)))\n (:identifiers (:sid . :s608.5) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005640@unknown@formal@none@1@S@K562 cells express endogenous WT1, which is downregulated as a response to induced differentiation along the erythroid and megakaryocytic pathways.@(((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 98) (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 137) (:start . 123) (:id . 61))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s608.7) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005641@unknown@formal@none@1@S@We now demonstrate that a forced exogenous expression of the four different isoforms of WT1 in K562 does not affect the differentiation response, as judged by accumulation of hemoglobin in response to hemin or the expression of megakaryocytic cell surface markers in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "forced") (:form . "forced") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "exogenous") (:form . 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"accumulation") (:end . 171)\n  (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 185)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 206)\n  (:start . 201) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 209) (:start . 207)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 224)\n  (:start . 214) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 242) (:start . 228) (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 247) (:start . 243)\n  (:id . 81))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 255)\n  (:start . 248) (:id . 82))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 263)\n  (:start . 256) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 266) (:start . 264)\n  (:id . 84))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 275)\n  (:start . 267) (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 278) (:start . 276)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 315) (:start . 279)\n  (:id . 87))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 317) (:start . 316)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 320) (:start . 317)\n  (:id . 89))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 321) (:start . 320)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 322) (:start . 321)\n  (:id . 91)))@@@1@50@((:ncues ((:id . :x608.8.1) (:span 105 108)))\n (:nscopes ((:id . :x608.8.1) (:span 105 144)))\n (:identifiers (:sid . :s608.8) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005642@unknown@formal@none@1@S@We conclude that downregulation of WT1 during induced differentiation of K562 cells is not a prerequisite for erythroid or megakaryocytic differentiation of these cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 69) (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "prerequisite") (:form . "prerequisite") (:end . 105)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 137) (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 153) (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 162)\n  (:start . 157) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x608.9.1) (:span 87 90)))\n (:nscopes ((:id . :x608.9.1) (:span 87 168)))\n (:identifiers (:sid . :s608.9) (:did . :|10378895|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005643@unknown@formal@none@1@S@GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.@(((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xL") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 102)\n  (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s609.1) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005644@unknown@formal@none@1@S@The transcription factor GATA-1 is essential for normal erythropoiesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 70) (:start . 56) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s609.2) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005645@unknown@formal@none@1@S@By examining in vitro-differentiated embryonic stem cells, we showed previously that in the absence of GATA-1, committed erythroid precursors fail to complete maturation and instead undergo apoptosis.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "examine") (:form . "examining") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "vitro-differentiated")\n  (:form . "vitro-differentiated") (:end . 36) (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 68) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "commit") (:form . "committed") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "VB") (:stem . "complete") (:form . "complete") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 169)\n  (:start . 159) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 189)\n  (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 199)\n  (:start . 190) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x609.3.1) (:span 142 146))\n  ((:id . :x609.3.2) (:span 92 99)))\n (:nscopes ((:id . :x609.3.1) (:span 142 169))\n  ((:id . :x609.3.2) (:span 92 109)))\n (:identifiers (:sid . :s609.3) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005646@unknown@formal@none@1@S@The mechanisms by which GATA-1 controls cell survival are unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x609.4.1) (:span 58 65)))\n (:hscopes ((:id . :x609.4.1) (:span 0 65)))\n (:identifiers (:sid . :s609.4) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005647@unknown@formal@none@1@S@Here we report that in erythroid cells, GATA-1 strongly induces the expression of the anti-apoptotic protein bcl-xL, but not the related proteins bcl-2 and mcl-1.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 100) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xL") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mcl-1") (:form . "mcl-1") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x609.5.1) (:span 121 124)))\n (:nscopes ((:id . :x609.5.1) (:span 121 161)))\n (:identifiers (:sid . :s609.5) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005648@unknown@formal@none@1@S@Consistent with a role for bcl-xL in mediating GATA-1-induced erythroid cell survival, in vitro-differentiated bcl-xL-/- embryonic stem cells fail to generate viable mature definitive erythroid cells, a phenotype resembling that of GATA-1 gene disruption.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xL") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "gata-1-induced") (:form . "GATA-1-induced")\n  (:end . 61) (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "vitro-differentiated")\n  (:form . "vitro-differentiated") (:end . 110) (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "bcl-xl-/-") (:form . "bcl-xL-/-") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 130)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 135) (:start . 131)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 158)\n  (:start . 150) (:id . 63))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 165)\n  (:start . 159) (:id . 64))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 172)\n  (:start . 166) (:id . 65))\n ((:tag . "JJ") (:stem . "definitive") (:form . "definitive") (:end . 183)\n  (:start . 173) (:id . 66))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 193)\n  (:start . 184) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 212)\n  (:start . 203) (:id . 71))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 223)\n  (:start . 213) (:id . 72))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 228) (:start . 224)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 238)\n  (:start . 232) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 243) (:start . 239)\n  (:id . 76))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 254)\n  (:start . 244) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x609.6.1) (:span 142 146)))\n (:nscopes ((:id . :x609.6.1) (:span 142 199)))\n (:identifiers (:sid . :s609.6) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005650@unknown@formal@none@1@S@Together, our data show that bcl-xL is essential for normal erythroid development and suggest a regulatory hierarchy in which bcl-xL is a critical downstream effector of GATA-1 and erythropoietin-mediated signals.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xL") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "hierarchy") (:form . "hierarchy") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xL") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 157)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 166)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "erythropoietin-mediated")\n  (:form . "erythropoietin-mediated") (:end . 204) (:start . 181) (:id . 71))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 212)\n  (:start . 205) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x609.8.1) (:span 86 93)))\n (:hscopes ((:id . :x609.8.1) (:span 86 212)))\n (:identifiers (:sid . :s609.8) (:did . :|10381501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005651@unknown@formal@none@1@S@NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "proapoptotic") (:form . "proapoptotic") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s610.1) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005652@unknown@formal@none@1@S@Recently NF-kappaB has been shown to have both proapoptotic and antiapoptotic functions.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "proapoptotic") (:form . "proapoptotic") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s610.2) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005653@unknown@formal@none@1@S@In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 9) (:start . 5)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 44)\n  (:start . 34) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 64) (:start . 49) (:id . 52))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s610.3) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005654@unknown@formal@none@1@S@Here we show that blockade of NF-kappaB activity, using a dominant negative IkappaBalpha, has opposite effects on these two apoptotic signals.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 88)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s610.4) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005655@unknown@formal@none@1@S@Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "P/I") (:form . "P/I") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 67)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ligand") (:form . "Ligand") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 102)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 115)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s610.5) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005656@unknown@formal@none@1@S@Inhibition of NF-kappaB activity inhibits the P/I mediated induction of FasL mRNA and decreases the level of apoptosis in these cultures, thus establishing NF-kappaB as a proapoptotic factor in this context.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "P/I") (:form . "P/I") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "establish") (:form . "establishing") (:end . 155)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 165)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "proapoptotic") (:form . "proapoptotic") (:end . 183)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 190)\n  (:start . 184) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 198) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 206)\n  (:start . 199) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s610.6) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005657@unknown@formal@none@1@S@Conversely, inhibition of NF-kappaB confers a tenfold increase in glucocorticoid mediated apoptosis, establishing that NF-kappaB also functions as an antiapoptotic factor.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tenfold") (:form . "tenfold") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 80) (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "establish") (:form . "establishing") (:end . 113)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 128)\n  (:start . 119) (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 143)\n  (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 163) (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 170)\n  (:start . 164) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s610.7) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005658@unknown@formal@none@1@S@We conclude that NF-kappaB is a context-dependent apoptosis regulator.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "context-dependent") (:form . "context-dependent")\n  (:end . 49) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s610.8) (:did . :|10381655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005660@unknown@formal@none@1@S@3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation.@(((:tag . "NN") (:stem . "3-deazaadenosine") (:form . "3-deazaadenosine")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "S-adenosylhomocysteine")\n  (:form . "S-adenosylhomocysteine") (:end . 42) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "hydrolase") (:form . "hydrolase") (:end . 52)\n  (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 62)\n  (:start . 53) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s611.1) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005661@unknown@formal@none@1@S@Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promotion") (:form . "promotion") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 78)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 90)\n  (:start . 79) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s611.2) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005662@unknown@formal@none@1@S@Previously we reported that 3-deazaadenosine (DZA), a potent inhibitor and substrate for S-adenosylhomocysteine hydrolase inhibits bacterial lipopolysaccharide-induced transcription of tumor necrosis factor-alpha and interleukin-1beta in mouse macrophage RAW 264.7 cells.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "3-deazaadenosine") (:form . "3-deazaadenosine")\n  (:end . 44) (:start . 28) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "S-adenosylhomocysteine")\n  (:form . "S-adenosylhomocysteine") (:end . 111) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "hydrolase") (:form . "hydrolase") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 167) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 181) (:start . 168) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 190)\n  (:start . 185) (:id . 64))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 199)\n  (:start . 191) (:id . 65))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 212)\n  (:start . 200) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 67))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 234) (:start . 217) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 237) (:start . 235)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 243)\n  (:start . 238) (:id . 70))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 254)\n  (:start . 244) (:id . 71))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 258) (:start . 255)\n  (:id . 72))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 264)\n  (:start . 259) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 270)\n  (:start . 265) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s611.3) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005663@unknown@formal@none@1@S@In this study, we demonstrate the effects of DZA on nuclear factor-kappaB (NF-kappaB) regulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 73) (:start . 60) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s611.4) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005664@unknown@formal@none@1@S@DZA inhibits the transcriptional activity of NF-kappaB through the hindrance of p65 (Rel-A) phosphorylation without reduction of its nuclear translocation and DNA binding activity.@(((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hindrance") (:form . "hindrance") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Rel-A") (:form . "Rel-A") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 107) (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 154) (:start . 141) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 170)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 179)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x611.5.1) (:span 108 115)))\n (:nscopes ((:id . :x611.5.1) (:span 108 179)))\n (:identifiers (:sid . :s611.5) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005665@unknown@formal@none@1@S@The inhibitory effect of DZA on NF-kappaB transcriptional activity is potentiated by the addition of homocysteine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "potentiate") (:form . "potentiated") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "homocysteine") (:form . "homocysteine") (:end . 113)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s611.6) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005666@unknown@formal@none@1@S@Taken together, DZA promotes the proteolytic degradation of IkappaBalpha, but not IkappaBbeta, resulting in an increase of DNA binding activity of NF-kappaB in the nucleus in the absence of its transcriptional activity in RAW 264.7 cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 186)\n  (:start . 179) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 209) (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 231)\n  (:start . 226) (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 237)\n  (:start . 232) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x611.7.1) (:span 179 186))\n  ((:id . :x611.7.2) (:span 78 81)))\n (:nscopes ((:id . :x611.7.1) (:span 179 237))\n  ((:id . :x611.7.2) (:span 78 93)))\n (:identifiers (:sid . :s611.7) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005667@unknown@formal@none@1@S@The reduction of IkappaBalpha by DZA is neither involved in IkappaB kinase complex activation nor modulated by the addition of homocysteine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "homocysteine") (:form . "homocysteine") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x611.8.1) (:span 40 47 94 97)))\n (:nscopes ((:id . :x611.8.1) (:span 40 139)))\n (:identifiers (:sid . :s611.8) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005668@unknown@formal@none@1@S@This study strongly suggests that DZA may be a potent drug for the treatment of diseases in which NF-kappaB plays a central pathogenic role, as well as a useful tool for studying the regulation and physiological functions of NF-kappaB.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DZA") (:form . "DZA") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 134)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 169) (:start . 166)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 178)\n  (:start . 170) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 75))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 193)\n  (:start . 183) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 211) (:start . 198) (:id . 78))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 221)\n  (:start . 212) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 234)\n  (:start . 225) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x611.9.1) (:span 38 41)) ((:id . :x611.9.2) (:span 20 28)))\n (:hscopes ((:id . :x611.9.1) (:span 38 234))\n  ((:id . :x611.9.2) (:span 20 234)))\n (:identifiers (:sid . :s611.9) (:did . :|10383397|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005670@unknown@formal@none@1@S@Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 86) (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 102) (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 119)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 124) (:start . 120)\n  (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "cultivation") (:form . "cultivation") (:end . 145)\n  (:start . 134) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 61))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 154)\n  (:start . 147) (:id . 62))\n ((:tag . "VBG") (:stem . "mimic") (:form . "mimicking") (:end . 164)\n  (:start . 155) (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 170)\n  (:start . 165) (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 178) (:start . 174)\n  (:id . 66))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 188)\n  (:start . 179) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 203)\n  (:start . 193) (:id . 69))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 208) (:start . 204)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "extravascular") (:form . "extravascular")\n  (:end . 222) (:start . 209) (:id . 71))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 230)\n  (:start . 223) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s612.2) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005671@unknown@formal@none@1@S@The mediator(s) of this maturation process has not been yet defined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mediator(s)") (:form . "mediator(s)") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x612.3.1) (:span 47 50)))\n (:nscopes ((:id . :x612.3.1) (:span 0 67)))\n (:identifiers (:sid . :s612.3) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005672@unknown@formal@none@1@S@We investigated the involvement of signal transducers and activators of transcription (STAT) factors in this phenomenon and reported the specific, time-dependent, activation of STAT1 protein starting at day 0/1 of cultivation and maximally expressed at day 5.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 161) (:start . 147) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 190)\n  (:start . 183) (:id . 70))\n ((:tag . "VBG") (:stem . "start") (:form . "starting") (:end . 199)\n  (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 206) (:start . 203)\n  (:id . 73))\n ((:tag . "CD") (:stem . "0/1") (:form . "0/1") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cultivation") (:form . "cultivation") (:end . 225)\n  (:start . 214) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 229) (:start . 226)\n  (:id . 77))\n ((:tag . "RB") (:stem . "maximally") (:form . "maximally") (:end . 239)\n  (:start . 230) (:id . 78))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 249)\n  (:start . 240) (:id . 79))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 252) (:start . 250)\n  (:id . 80))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 256) (:start . 253)\n  (:id . 81))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 258) (:start . 257)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s612.4) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005673@unknown@formal@none@1@S@STAT1 activity was evident on the STAT binding sequences (SBE) present in the promoters of genes which are up-regulated during monocyte to macrophage maturation such as FcgammaRI and ICAM-1, and in the promoter of the transcription factor IFN regulatory factor-1.@(((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SBE") (:form . "SBE") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 119)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 160)\n  (:start . 150) (:id . 67))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "FcgammaRI") (:form . "FcgammaRI") (:end . 178)\n  (:start . 169) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 189)\n  (:start . 183) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 210)\n  (:start . 202) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 79))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 231) (:start . 218) (:id . 80))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 238)\n  (:start . 232) (:id . 81))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 242) (:start . 239)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 253)\n  (:start . 243) (:id . 83))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 262)\n  (:start . 254) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s612.5) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005674@unknown@formal@none@1@S@Moreover, the effect of cell adhesion to fibronectin or laminin was studied to investigate mechanisms involved in STAT1 activation.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "laminin") (:form . "laminin") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s612.6) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005675@unknown@formal@none@1@S@Compared with monocytes adherent on plastic surfaces, freshly isolated cells allowed to adhere either to fibronectin- or laminin-coated flasks exhibited an increased STAT1 binding activity both in control and in IFN-gamma-treated cells.@(((:tag . "VBN") (:stem . "compare") (:form . "Compared") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "plastic") (:form . "plastic") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "VB") (:stem . "adhere") (:form . "adhere") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fibronectin-") (:form . "fibronectin-") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "laminin-coated") (:form . "laminin-coated")\n  (:end . 135) (:start . 121) (:id . 60))\n ((:tag . "NNS") (:stem . "flask") (:form . "flasks") (:end . 142)\n  (:start . 136) (:id . 61))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 152)\n  (:start . 143) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 188)\n  (:start . 180) (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 204)\n  (:start . 197) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "ifn-gamma-treated") (:form . "IFN-gamma-treated")\n  (:end . 229) (:start . 212) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 235)\n  (:start . 230) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s612.7) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005676@unknown@formal@none@1@S@The molecular events leading to enhanced STAT1 activation and cytokine responsiveness concerned both Y701 and S727 STAT1 phosphorylation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 85) (:start . 71) (:id . 52))\n ((:tag . "VBD") (:stem . "concern") (:form . "concerned") (:end . 95)\n  (:start . 86) (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "y701") (:form . "Y701") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "s727") (:form . "S727") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 136) (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s612.8) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005677@unknown@formal@none@1@S@Exogenous addition of transforming growth factor-beta, which exerts an inhibitory effect on some monocytic differentiation markers, inhibited macrophage maturation, integrin expression and STAT1 binding activity.@(((:tag . "JJ") (:stem . "exogenous") (:form . "Exogenous") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 122) (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 130)\n  (:start . 123) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 141)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 152)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 163)\n  (:start . 153) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 63))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 173)\n  (:start . 165) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 184)\n  (:start . 174) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 66))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 194)\n  (:start . 189) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 202)\n  (:start . 195) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 211)\n  (:start . 203) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s612.9) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005678@unknown@formal@none@1@S@Taken together these results indicate that STAT1 plays a pivotal role in the differentiation/maturation process of monocytes as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes, such as ICAM-1 and FcgammaRI.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation/maturation")\n  (:form . "differentiation/maturation") (:end . 103) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 150) (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 157)\n  (:start . 151) (:id . 63))\n ((:tag . "RB") (:stem . "initially") (:form . "initially") (:end . 167)\n  (:start . 158) (:id . 64))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 177)\n  (:start . 168) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 190)\n  (:start . 181) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 68))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 199) (:start . 195)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 204) (:start . 200)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 71))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 216)\n  (:start . 208) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 231)\n  (:start . 221) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 245)\n  (:start . 235) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 251)\n  (:start . 246) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 252) (:start . 251)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 257) (:start . 253)\n  (:id . 79))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 260) (:start . 258)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 267)\n  (:start . 261) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 271) (:start . 268)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "FcgammaRI") (:form . "FcgammaRI") (:end . 281)\n  (:start . 272) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x612.10.1) (:span 29 42)))\n (:hscopes ((:id . :x612.10.1) (:span 29 281)))\n (:identifiers (:sid . :s612.10) (:did . :|10383940|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005680@unknown@formal@none@1@S@NF-kappa B is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 45) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "extrinsic") (:form . "extrinsic") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s613.2) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005681@unknown@formal@none@1@S@Our findings show that suppression of NF-kappa B activity with cell-permeable SN50 peptide, which masks the nuclear localization sequence of NF-kappa B1 dimers and prevents their nuclear localization, induces apoptosis in resting normal human PBL.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-permeable") (:form . "cell-permeable")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "sn50") (:form . "SN50") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "mask") (:form . "masks") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 172)\n  (:start . 164) (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 186)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 199)\n  (:start . 187) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 208)\n  (:start . 201) (:id . 72))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 218)\n  (:start . 209) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 229)\n  (:start . 222) (:id . 75))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 236)\n  (:start . 230) (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 242)\n  (:start . 237) (:id . 77))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 246) (:start . 243)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s613.3) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005682@unknown@formal@none@1@S@Inhibition of NF-kappa B resulted in the externalization of phosphatidylserine, induction of DNA breaks, and morphological changes consistent with apoptosis.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "externalization") (:form . "externalization")\n  (:end . 56) (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphatidylserine") (:form . "phosphatidylserine")\n  (:end . 78) (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "break") (:form . "breaks") (:end . 103)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "morphological") (:form . "morphological")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 156)\n  (:start . 147) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s613.4) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005683@unknown@formal@none@1@S@DNA fragmentation was efficiently blocked by the caspase inhibitor Z-VAD-fmk and partially blocked by Ac-DEVD-fmk, suggesting that SN50-mediated apoptosis is caspase-dependent.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NNP") (:stem . "Z-VAD-fmk") (:form . "Z-VAD-fmk") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ac-DEVD-fmk") (:form . "Ac-DEVD-fmk") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "sn50-mediated") (:form . "SN50-mediated")\n  (:end . 144) (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 154)\n  (:start . 145) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 157) (:start . 155)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "caspase-dependent") (:form . "caspase-dependent")\n  (:end . 175) (:start . 158) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x613.5.1) (:span 115 125)))\n (:hscopes ((:id . :x613.5.1) (:span 115 175)))\n (:identifiers (:sid . :s613.5) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005684@unknown@formal@none@1@S@Interestingly, apoptosis induced by NF-kappa B suppression, in contrast to that induced by TPEN (N,N,N',N'-tetrakis [2-pyridylmethyl]ethylenediamine) or soluble Fas ligand (CD95), was observed in the absence of active death effector proteases caspase-1-like (IL-1 converting enzyme), caspase-3-like (CPP32/Yama/apopain), and caspase-6-like and without cleavage of caspase-3 substrates poly(ADP-ribose) polymerase and DNA fragmentation factor-45.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . 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5005685@unknown@formal@none@1@S@These findings suggest either low level of activation is required or that different caspases are involved.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x613.7.1) (:span 23 29 66 68))\n  ((:id . :x613.7.3) (:span 15 22)))\n (:hscopes ((:id . :x613.7.1) (:span 23 105))\n  ((:id . :x613.7.3) (:span 15 105)))\n (:identifiers (:sid . :s613.7) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005686@unknown@formal@none@1@S@Preactivation of T cells resulting in NF-kappa B nuclear translocation protected cells from SN50-induced apoptosis.@(((:tag . "NNP") (:stem . "Preactivation") (:form . "Preactivation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "protect") (:form . "protected") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sn50-induced") (:form . "SN50-induced") (:end . 104)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s613.8) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005687@unknown@formal@none@1@S@Our findings demonstrate an essential role of NF-kappa B in survival of naive PBL.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s613.9) (:did . :|10395645|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005688@unknown@formal@none@1@S@Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-activated")\n  (:form . "lipopolysaccharide-activated") (:end . 56) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "toll-like") (:form . "toll-like") (:end . 66)\n  (:start . 57) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 77) (:start . 76)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s614.1) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005690@unknown@formal@none@1@S@Here, we investigate further the events triggered by TLR2 in response to LPS.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 20)\n  (:start . 9) (:id . 45))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s614.3) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005691@unknown@formal@none@1@S@We show that TLR2 associates with the high-affinity LPS binding protein membrane CD14 to serve as an LPS receptor complex, and that LPS treatment enhances the oligomerization of TLR2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 145)\n  (:start . 136) (:id . 66))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "oligomerization") (:form . "oligomerization")\n  (:end . 174) (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 182) (:start . 178)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s614.4) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005692@unknown@formal@none@1@S@Concomitant with receptor oligomerization, the IL-1R-associated kinase (IRAK) is recruited to the TLR2 complex.@(((:tag . "JJ") (:stem . "concomitant") (:form . "Concomitant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "oligomerization") (:form . "oligomerization")\n  (:end . 41) (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-1r-associated") (:form . "IL-1R-associated")\n  (:end . 63) (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 70)\n  (:start . 64) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s614.5) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005693@unknown@formal@none@1@S@Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa fail to recruit IRAK, which is consistent with the inability of these mutants to transmit LPS cellular signaling.@(((:tag . "JJ") (:stem . "intracellular") (:form . "Intracellular")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "CD") (:stem . "141") (:form . "141") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "recruit") (:form . "recruit") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "VB") (:stem . "transmit") (:form . "transmit") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 174)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 184)\n  (:start . 175) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x614.6.2) (:span 62 64)))\n (:ncues ((:id . :x614.6.1) (:span 72 76)) ((:id . :x614.6.3) (:span 40 47)))\n (:hscopes ((:id . :x614.6.2) (:span 48 71)))\n (:nscopes ((:id . :x614.6.1) (:span 72 92))\n  ((:id . :x614.6.3) (:span 40 71)))\n (:identifiers (:sid . :s614.6) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005694@unknown@formal@none@1@S@Moreover, both deletion mutants could still form complexes with wild-type TLR2 and act in a dominant-negative (DN) fashion to block TLR2-mediated signal transduction.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 109) (:start . 92) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dn") (:form . "DN") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "tlr2-mediated") (:form . "TLR2-mediated")\n  (:end . 145) (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 165)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s614.7) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005695@unknown@formal@none@1@S@DN constructs of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing kinase, when coexpressed with TLR2, abrogate TLR2-mediated NF-kappaB activation.@(((:tag . "JJ") (:stem . "dn") (:form . "DN") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 79) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB-inducing") (:form . "NF-kappaB-inducing")\n  (:end . 112) (:start . 94) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 137)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TLR2") (:form . "TLR2") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "abrogate") (:form . "abrogate") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "JJ") (:stem . "tlr2-mediated") (:form . "TLR2-mediated")\n  (:end . 171) (:start . 158) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 181)\n  (:start . 172) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 192)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s614.8) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005696@unknown@formal@none@1@S@These results reveal a conserved signaling pathway for TLR2 and IL-1Rs and suggest a molecular mechanism for the inhibition of TLR2 by DN variants.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TLR2") (:form . "TLR2") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-1R") (:form . "IL-1Rs") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tlr2") (:form . "TLR2") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dn") (:form . "DN") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x614.9.1) (:span 75 82)))\n (:hscopes ((:id . :x614.9.1) (:span 75 146)))\n (:identifiers (:sid . :s614.9) (:did . :|10395652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005697@unknown@formal@none@1@S@Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "3-STAT5a") (:form . "3-STAT5a") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x615.1.1) (:span 93 96)))\n (:nscopes ((:id . :x615.1.1) (:span 93 115)))\n (:identifiers (:sid . :s615.1) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005698@unknown@formal@none@1@S@CD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells.@(((:tag . "NNP") (:stem . "CD40/CD40") (:form . "CD40/CD40") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s615.2) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005700@unknown@formal@none@1@S@Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s615.4) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005701@unknown@formal@none@1@S@After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 128) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "preparation") (:form . "preparations") (:end . 146)\n  (:start . 134) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x615.5.1) (:span 66 69)))\n (:nscopes ((:id . :x615.5.1) (:span 66 81)))\n (:identifiers (:sid . :s615.5) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005702@unknown@formal@none@1@S@However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 144)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 163)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 181)\n  (:start . 172) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 193)\n  (:start . 188) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 76))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 202)\n  (:start . 195) (:id . 77))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 206) (:start . 203)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 210) (:start . 207)\n  (:id . 79))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 215) (:start . 211)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 223)\n  (:start . 216) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 228) (:start . 227)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 234)\n  (:start . 229) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s615.6) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005703@unknown@formal@none@1@S@In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 161) (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 171)\n  (:start . 162) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 184)\n  (:start . 176) (:id . 71))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 189) (:start . 185)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cd40-activated") (:form . "CD40-activated")\n  (:end . 207) (:start . 193) (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 217)\n  (:start . 208) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 223) (:start . 219)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 234)\n  (:start . 224) (:id . 78))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 244)\n  (:start . 235) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 247) (:start . 245)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "STAT5a") (:form . "STAT5a") (:end . 254)\n  (:start . 248) (:id . 81))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 258) (:start . 255)\n  (:id . 82))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 266)\n  (:start . 259) (:id . 83))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 275)\n  (:start . 267) (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 278) (:start . 276)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 282) (:start . 279)\n  (:id . 86))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 290)\n  (:start . 283) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 291) (:start . 290)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s615.7) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005704@unknown@formal@none@1@S@These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x615.8.1) (:span 14 21)))\n (:hscopes ((:id . :x615.8.1) (:span 14 114)))\n (:identifiers (:sid . :s615.8) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005705@unknown@formal@none@1@S@This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced B cell activation has been reported.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "cd40-induced") (:form . "CD40-induced") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ligand+") (:form . "ligand+") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "hyper") (:form . "hyper") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . "NNP") (:stem . "IgM") (:form . "IgM") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "WP") (:stem . "whom") (:form . "whom") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cd40-induced") (:form . "CD40-induced") (:end . 174)\n  (:start . 162) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 192)\n  (:start . 182) (:id . 70))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 210)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s615.9) (:did . :|10395671|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005706@unknown@formal@none@1@S@Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "supernatant") (:form . "supernatant") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "carcinoma") (:form . "carcinomas") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s616.1) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005707@unknown@formal@none@1@S@T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 140)\n  (:start . 134) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s616.2) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005708@unknown@formal@none@1@S@We determined the mechanism of NF-kappaB suppression in T cells of RCC patient and determined whether supernatant fluid from RCC explants (RCC-S) induced the same phenotype of NF-kappaB suppression in normal T cells that is observed in patient T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "supernatant") (:form . "supernatant") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "explant") (:form . "explants") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RCC-S") (:form . "RCC-S") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 153)\n  (:start . 146) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 185)\n  (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 197)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 207)\n  (:start . 201) (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 209) (:start . 208)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 76))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 220) (:start . 216)\n  (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 223) (:start . 221)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 232)\n  (:start . 224) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 80))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 243)\n  (:start . 236) (:id . 81))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 245) (:start . 244)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 251)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x616.3.1) (:span 94 101)))\n (:hscopes ((:id . :x616.3.1) (:span 94 251)))\n (:identifiers (:sid . :s616.3) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005710@unknown@formal@none@1@S@In some patients, no activation of RelA/NFkappaB1-binding activity was detectable, while in others kappaB-binding activity was modestly induced but the duration was reduced.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rela/nfkappab1-binding")\n  (:form . "RelA/NFkappaB1-binding") (:end . 57) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "JJ") (:stem . "kappab-binding") (:form . "kappaB-binding")\n  (:end . 113) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "RB") (:stem . "modestly") (:form . "modestly") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 143)\n  (:start . 136) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "duration") (:form . "duration") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x616.5.1) (:span 18 20)))\n (:nscopes ((:id . :x616.5.1) (:span 18 81)))\n (:identifiers (:sid . :s616.5) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005711@unknown@formal@none@1@S@IkappaBalpha was degraded normally following stimulation in both normal controls and T cells from RCC patients.@(((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 56)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s616.6) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005712@unknown@formal@none@1@S@RCC-S did not alter the cytoplasmic levels of RelA and NF-kappaB1 but did suppress their nuclear localization and inhibited the activation of RelA/NF-kappaB1 binding complexes.@(((:tag . "NNP") (:stem . "RCC-S") (:form . "RCC-S") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB1") (:form . "NF-kappaB1") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 88)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rela/nf-kappab1") (:form . "RelA/NF-kappaB1")\n  (:end . 157) (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 175)\n  (:start . 166) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x616.7.1) (:span 10 13)))\n (:nscopes ((:id . :x616.7.1) (:span 10 65)))\n (:identifiers (:sid . :s616.7) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005713@unknown@formal@none@1@S@These results show that RCC-S can induce in normal T cells the same phenotype of impaired NF-kappaB activation that is detected in T cells of RCC patient.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "rcc-s") (:form . "RCC-S") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 153)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s616.8) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005714@unknown@formal@none@1@S@It also appears that NF-kappaB suppression by RCC-S may contribute to the immunosuppression of host immunity.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RCC-S") (:form . "RCC-S") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 91) (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x616.9.1) (:span 52 55)) ((:id . :x616.9.2) (:span 8 15)))\n (:hscopes ((:id . :x616.9.1) (:span 52 108))\n  ((:id . :x616.9.2) (:span 8 108)))\n (:identifiers (:sid . :s616.9) (:did . :|10402173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005715@unknown@formal@none@1@S@Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels.@(((:tag . "JJ") (:stem . "monoclonal") (:form . "Monoclonal") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "anti-endothelial") (:form . "anti-endothelial")\n  (:end . 27) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Takayasu") (:form . "Takayasu") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "arteritis") (:form . "arteritis") (:end . 82)\n  (:start . 73) (:id . 51))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 91)\n  (:start . 83) (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 103)\n  (:start . 92) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 120)\n  (:start . 115) (:id . 56))\n ((:tag . "NNS") (:stem . "vessel") (:form . "vessels") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s617.1) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005716@unknown@formal@none@1@S@OBJECTIVE: To create monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis to evaluate their ability to activate human umbilical vein endothelial cells (HUVEC), and to characterize the mechanism of EC activation.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "To") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "create") (:form . "create") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "anti-endothelial") (:form . "anti-endothelial")\n  (:end . 48) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mAECA") (:form . "mAECA") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Takayasu") (:form . "Takayasu") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "arteritis") (:form . "arteritis") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 165)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 182)\n  (:start . 171) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 195)\n  (:start . 190) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 75))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 217)\n  (:start . 205) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 77))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 231)\n  (:start . 222) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 237) (:start . 235)\n  (:id . 80))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 248)\n  (:start . 238) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s617.2) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005717@unknown@formal@none@1@S@METHODS: A panel of mAECA was generated from peripheral blood lymphocytes of a patient with Takayasu arteritis, using Epstein-Barr virus transformation.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "mAECA") (:form . "mAECA") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 39)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Takayasu") (:form . "Takayasu") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "arteritis") (:form . "arteritis") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 117) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 130)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 151) (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s617.3) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005718@unknown@formal@none@1@S@Activity against macrovascular EC (HUVEC) and microvascular EC (human bone marrow EC immortalized by SV40) antigens was detected by enzyme-linked immunosorbent assay.@(((:tag . "NN") (:stem . "activity") (:form . "Activity") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "macrovascular") (:form . "macrovascular")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "microvascular") (:form . "microvascular")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "immortalize") (:form . "immortalized") (:end . 97)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "SV40") (:form . "SV40") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "enzyme-linked") (:form . "enzyme-linked")\n  (:end . 145) (:start . 132) (:id . 65))\n ((:tag . "JJ") (:stem . "immunosorbent") (:form . "immunosorbent")\n  (:end . 159) (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s617.4) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005720@unknown@formal@none@1@S@The binding of the mAECA to human aortic EC was studied by immunohistochemistry.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "maeca") (:form . "mAECA") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "aortic") (:form . "aortic") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 79) (:start . 59) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s617.6) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005721@unknown@formal@none@1@S@The secretion levels of interleukin-6 (IL-6) and von Willebrand factor (vWF) were determined, to serve as markers for EC activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "von") (:form . "von") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Willebrand") (:form . "Willebrand") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "vWF") (:form . "vWF") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 113)\n  (:start . 106) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 131)\n  (:start . 121) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s617.7) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005722@unknown@formal@none@1@S@The activated EC were examined for the adherence of a monocytic cell line (U937), as well as for expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and E-selectin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 89) (:start . 85)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 119)\n  (:start . 111) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 133)\n  (:start . 125) (:id . 67))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 142)\n  (:start . 134) (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 144) (:start . 143)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 159) (:start . 146) (:id . 71))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 168)\n  (:start . 160) (:id . 72))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 177)\n  (:start . 169) (:id . 73))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 195)\n  (:start . 185) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s617.8) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005723@unknown@formal@none@1@S@In addition, nuclear extracts of the mAECA-treated EC were analyzed for the induction of translocation of nuclear factor kappaB (NF-kappaB), using a specific NF-kappaB oligoprobe in an electrophoretic mobility shift assay.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "maeca-treated") (:form . "mAECA-treated")\n  (:end . 50) (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 146) (:start . 141)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "oligoprobe") (:form . "oligoprobe") (:end . 178)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 200) (:start . 185) (:id . 73))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 209)\n  (:start . 201) (:id . 74))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 215)\n  (:start . 210) (:id . 75))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 221)\n  (:start . 216) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s617.9) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005724@unknown@formal@none@1@S@RESULTS: Six mAECA were selected, the mixture of which produced 100% inhibition of binding of the original IgG (from the patient with Takayasu arteritis) to HUVEC.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CD") (:stem . "six") (:form . "Six") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "maeca") (:form . "mAECA") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mixture") (:form . "mixture") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 106)\n  (:start . 98) (:id . 61))\n ((:tag . "NN") (:stem . "igg") (:form . "IgG") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 128)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Takayasu") (:form . "Takayasu") (:end . 142)\n  (:start . 134) (:id . 68))\n ((:tag . "NN") (:stem . "arteritis") (:form . "arteritis") (:end . 152)\n  (:start . 143) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 162)\n  (:start . 157) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s617.10) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005725@unknown@formal@none@1@S@All mAECA possessed high activity against macrovascular EC, but none had significant antimicrovascular EC activity.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mAECA") (:form . "mAECA") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "possess") (:form . "possessed") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "macrovascular") (:form . "macrovascular")\n  (:end . 55) (:start . 42) (:id . 48))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "antimicrovascular") (:form . "antimicrovascular")\n  (:end . 102) (:start . 85) (:id . 55))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x617.11.1) (:span 64 68)))\n (:nscopes ((:id . :x617.11.1) (:span 64 114)))\n (:identifiers (:sid . :s617.11) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005726@unknown@formal@none@1@S@The mAECA, but not normal human IgG, had anti-human aortic EC activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "maeca") (:form . "mAECA") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "igg") (:form . "IgG") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-human") (:form . "anti-human") (:end . 51)\n  (:start . 41) (:id . 52))\n ((:tag . "JJ") (:stem . "aortic") (:form . "aortic") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x617.12.1) (:span 15 18)))\n (:nscopes ((:id . :x617.12.1) (:span 15 35)))\n (:identifiers (:sid . :s617.12) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005727@unknown@formal@none@1@S@Four of the 6 mAECA activated EC, manifested by increased IL-6 and vWF secretion.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "maeca") (:form . "mAECA") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "manifest") (:form . "manifested") (:end . 44)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "vwf") (:form . "vWF") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s617.13) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005728@unknown@formal@none@1@S@The 4 mAECA induced EC expression of adhesion molecules and increased adhesion of U937 monocytic cells to EC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "maeca") (:form . "mAECA") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s617.14) (:did . :|10403270|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005730@unknown@formal@none@1@S@CONCLUSION: Our findings suggest that AECA may directly stimulate EC in Takayasu arteritis through elevation of adhesion molecule expression associated with NF-kappaB activation and adhesion of monocytes, and may therefore play a pathogenic role in the development of the vasculopathy in Takayasu arteritis.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AECA") (:form . 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5005731@unknown@formal@none@1@S@The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "engage") (:form . "engages") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 114) (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 123)\n  (:start . 115) (:id . 56))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "receptor-interacting")\n  (:form . "receptor-interacting") (:end . 154) (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 167) (:start . 164)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 172) (:start . 169)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 177) (:start . 173)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 188)\n  (:start . 182) (:id . 67))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 198)\n  (:start . 189) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 201) (:start . 199)\n  (:id . 69))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 209)\n  (:start . 202) (:id . 70))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 213) (:start . 210)\n  (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 217) (:start . 214)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 227)\n  (:start . 218) (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 238)\n  (:start . 228) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x618.1.1) (:span 178 181)))\n (:nscopes ((:id . :x618.1.1) (:span 178 238)))\n (:identifiers (:sid . :s618.1) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005732@unknown@formal@none@1@S@A site in the Epstein-Barr virus (EBV) transforming protein LMP1 that constitutively associates with the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD to mediate NF-kappaB and c-Jun N-terminal kinase activation is critical for long-term lymphoblastoid cell proliferation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 26)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 51)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 84) (:start . 70) (:id . 55))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNFR1)-associated") (:form . "TNFR1)-associated")\n  (:end . 156) (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "tradd") (:form . "TRADD") (:end . 183)\n  (:start . 178) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 204)\n  (:start . 195) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 214)\n  (:start . 209) (:id . 74))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 225)\n  (:start . 215) (:id . 75))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 232)\n  (:start . 226) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 243)\n  (:start . 233) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 246) (:start . 244)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 255)\n  (:start . 247) (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 259) (:start . 256)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 269)\n  (:start . 260) (:id . 81))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 284) (:start . 270) (:id . 82))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 289) (:start . 285)\n  (:id . 83))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 303) (:start . 290) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 304) (:start . 303)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s618.2) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005733@unknown@formal@none@1@S@We now find that LMP1 signaling through TRADD differs from TNFR1 signaling through TRADD.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tnfr1") (:form . "TNFR1") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s618.3) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005734@unknown@formal@none@1@S@LMP1 needs only 11 amino acids to activate NF-kappaB or synergize with TRADD in NF-kappaB activation, while TNFR1 requires approximately 70 residues.@(((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "need") (:form . "needs") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NNP") (:stem . "TNFR1") (:form . "TNFR1") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 136) (:start . 123) (:id . 62))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s618.4) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005735@unknown@formal@none@1@S@Further, LMP1 does not require TRADD residues 294 to 312 for NF-kappaB activation, while TNFR1 requires TRADD residues 296 to 302.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "CD") (:stem . "294") (:form . "294") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "312") (:form . "312") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNFR1") (:form . "TNFR1") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "CD") (:stem . "296") (:form . "296") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "CD") (:stem . "302") (:form . "302") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x618.5.1) (:span 19 22)))\n (:nscopes ((:id . :x618.5.1) (:span 19 81)))\n (:identifiers (:sid . :s618.5) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005736@unknown@formal@none@1@S@LMP1 is partially blocked for NF-kappaB activation by a TRADD mutant consisting of residues 122 to 293.@(((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "CD") (:stem . "122") (:form . "122") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s618.6) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005737@unknown@formal@none@1@S@Unlike TNFR1, LMP1 can interact directly with receptor-interacting protein (RIP) and stably associates with RIP in EBV-transformed lymphoblastoid cell lines.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TNFR1") (:form . "TNFR1") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "receptor-interacting")\n  (:form . "receptor-interacting") (:end . 66) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 130) (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 145) (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 156)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s618.7) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005738@unknown@formal@none@1@S@Surprisingly, LMP1 does not require RIP for NF-kappaB activation.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x618.8.1) (:span 24 27)))\n (:nscopes ((:id . :x618.8.1) (:span 24 64)))\n (:identifiers (:sid . :s618.8) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005740@unknown@formal@none@1@S@These results add a different perspective to the molecular interactions through which LMP1, TRADD, and RIP participate in B-lymphocyte activation and growth.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "add") (:form . "add") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "perspective") (:form . "perspective") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RIP") (:form . "RIP") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 118)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 134) (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 156)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s618.10) (:did . :|10409763|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005741@unknown@formal@none@1@S@Regulatory effects of interleukin-11 during acute lung inflammatory injury.@(((:tag . "JJ") (:stem . "regulatory") (:form . "Regulatory") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-11") (:form . "interleukin-11")\n  (:end . 36) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 67)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s619.1) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005742@unknown@formal@none@1@S@The role of interleukin-11 (IL-11) was evaluated in the IgG immune complex model of acute lung injury in rats.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-11") (:form . "interleukin-11")\n  (:end . 26) (:start . 12) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-11") (:form . "IL-11") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s619.2) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005743@unknown@formal@none@1@S@IL-11 mRNA and protein were both up-regulated during the course of this inflammatory response.@(((:tag . "NNP") (:stem . "IL-11") (:form . "IL-11") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s619.3) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005744@unknown@formal@none@1@S@Exogenously administered IL-11 substantially reduced, in a dose-dependent manner, the intrapulmonary accumulation of neutrophils and the lung vascular leak of albumin.@(((:tag . "RB") (:stem . "exogenously") (:form . "Exogenously") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "administer") (:form . "administered") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "il-11") (:form . "IL-11") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 44) (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 52)\n  (:start . 45) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 73) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intrapulmonary") (:form . "intrapulmonary")\n  (:end . 100) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 113)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 128)\n  (:start . 117) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 150)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "leak") (:form . "leak") (:end . 155) (:start . 151)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "albumin") (:form . "albumin") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s619.4) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005745@unknown@formal@none@1@S@These in vivo anti-inflammatory effects of IL-11 were associated with reduced NF-kappaB activation in lung, reduced levels of tumor necrosis factor alpha (TNF-alpha) in bronchoalveolar lavage (BAL) fluids, and diminished up-regulation of lung vascular ICAM-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 31) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-11") (:form . "IL-11") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "bronchoalveolar") (:form . "bronchoalveolar")\n  (:end . 184) (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "lavage") (:form . "lavage") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "BAL") (:form . "BAL") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "fluid") (:form . "fluids") (:end . 204)\n  (:start . 198) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 220)\n  (:start . 210) (:id . 77))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 234) (:start . 221) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 79))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 242) (:start . 238)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 251)\n  (:start . 243) (:id . 81))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 258)\n  (:start . 252) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s619.5) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005746@unknown@formal@none@1@S@It is interesting that IL-11 did not affect BAL fluid content of the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-inducible neutrophil chemoattractant (CINC); the presence of IL-11 did not affect these chemokines.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-11") (:form . "IL-11") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "bal") (:form . "BAL") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CXC") (:form . "CXC") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 108)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "protein-2") (:form . "protein-2") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mip-2") (:form . "MIP-2") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cytokine-inducible") (:form . "cytokine-inducible")\n  (:end . 149) (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 176) (:start . 161) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CINC") (:form . "CINC") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-11") (:form . "IL-11") (:end . 206)\n  (:start . 201) (:id . 75))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 210) (:start . 207)\n  (:id . 76))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 214) (:start . 211)\n  (:id . 77))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 221)\n  (:start . 215) (:id . 78))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 227)\n  (:start . 222) (:id . 79))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 238)\n  (:start . 228) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x619.6.1) (:span 211 214))\n  ((:id . :x619.6.2) (:span 33 36)))\n (:nscopes ((:id . :x619.6.1) (:span 211 238))\n  ((:id . :x619.6.2) (:span 33 183)))\n (:identifiers (:sid . :s619.6) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005747@unknown@formal@none@1@S@However, BAL content of C5a was reduced by IL-11.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "bal") (:form . "BAL") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-11") (:form . "IL-11") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s619.7) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005748@unknown@formal@none@1@S@These data indicate that IL-11 is a regulatory cytokine in the lung and that, like other members of this family, its anti-inflammatory properties appear to be linked to its suppression of NF-kappaB activation, diminished production of TNF-alpha, and reduced up-regulation of lung vascular ICAM-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-11") (:form . "IL-11") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . 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"production") (:end . 231)\n  (:start . 221) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 244)\n  (:start . 235) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 249) (:start . 246)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 257)\n  (:start . 250) (:id . 84))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 271) (:start . 258) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 274) (:start . 272)\n  (:id . 86))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 279) (:start . 275)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 288)\n  (:start . 280) (:id . 88))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 295)\n  (:start . 289) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x619.8.1) (:span 146 152))\n  ((:id . :x619.8.2) (:span 11 24)))\n (:hscopes ((:id . :x619.8.1) (:span 113 295))\n  ((:id . :x619.8.2) (:span 11 295)))\n (:identifiers (:sid . :s619.8) (:did . :|10411003|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005750@unknown@formal@none@1@S@We describe an enhancer site in the third intron of tumor necrosis factor alpha (TNF-alpha).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s620.2) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005751@unknown@formal@none@1@S@A reporter construct containing the 5'-flanking region of the mouse TNF-alpha gene displayed weak activity when transfected into RAW264.7 macrophage-like cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 123)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "raw264.7") (:form . "RAW264.7") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 153) (:start . 138) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s620.3) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005752@unknown@formal@none@1@S@The addition of the third intron of TNF-alpha to this construct resulted in an enhancement of CAT protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s620.4) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005753@unknown@formal@none@1@S@This enhancement was eliminated if a conserved 20-bp sequence was removed from the intron or if a dominant-negative ets-binding factor was co-transfected with the reporter gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "eliminate") (:form . "eliminated") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "20-bp") (:form . "20-bp") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 115) (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "ets-binding") (:form . "ets-binding") (:end . 127)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "co-transfecte") (:form . "co-transfected")\n  (:end . 153) (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s620.5) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005754@unknown@formal@none@1@S@Mutations of this site that destroyed potential ets transcription factor binding sites had reduced transcriptional activity.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "destroy") (:form . "destroyed") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 114) (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x620.6.1) (:span 38 47)))\n (:hscopes ((:id . :x620.6.1) (:span 38 86)))\n (:identifiers (:sid . :s620.6) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005755@unknown@formal@none@1@S@The major transcription factor that bound to the oligonucleotide was confirmed to be GABP by supershift and competition analysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s620.7) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005756@unknown@formal@none@1@S@In RAW264.7 cells, the binding was constitutive, however, in bone marrow-derived macrophages binding activity was shown to be interferon-gamma inducible.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "raw264.7") (:form . "RAW264.7") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 47)\n  (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "marrow-derived") (:form . "marrow-derived")\n  (:end . 80) (:start . 66) (:id . 55))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 142) (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s620.8) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005757@unknown@formal@none@1@S@This may imply a role for ets transcription factors in the production of TNF-alpha.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "imply") (:form . "imply") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x620.9.1) (:span 9 14)) ((:id . :x620.9.2) (:span 5 8)))\n (:hscopes ((:id . :x620.9.1) (:span 9 82)) ((:id . :x620.9.2) (:span 5 82)))\n (:identifiers (:sid . :s620.9) (:did . :|10411007|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005758@unknown@formal@none@1@S@Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression.@(((:tag . "JJ") (:stem . "abnormal") (:form . "Abnormal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "erythematosus") (:form . "erythematosus")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "p65-rela") (:form . "p65-RelA") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s621.1) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005760@unknown@formal@none@1@S@Because NF-kappa B contributes to the transcription of numerous inflammatory genes and has been shown to be a molecular target of antiinflammatory drugs, we sought to characterize the functional role of the NF-kappa B protein complex in lupus T cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 146) (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 152)\n  (:start . 147) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 179)\n  (:start . 167) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 215)\n  (:start . 207) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 217) (:start . 216)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 225)\n  (:start . 218) (:id . 77))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 233)\n  (:start . 226) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 79))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 242)\n  (:start . 237) (:id . 80))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 244) (:start . 243)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 250)\n  (:start . 245) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s621.3) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005761@unknown@formal@none@1@S@Freshly isolated T cells from lupus patients, rheumatoid arthritis (RA) patients, and normal individuals were activated physiologically via the TCR with anti-CD3 and anti-CD28 Abs to assess proximal membrane signaling, and with PMA and a calcium ionophore (A23187) to bypass membrane-mediated signaling events.@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lupus") (:form . "lupus") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 104)\n  (:start . 93) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 135) (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 175)\n  (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 189)\n  (:start . 183) (:id . 72))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 198)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 207)\n  (:start . 199) (:id . 74))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 217)\n  (:start . 208) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 227) (:start . 223)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 231) (:start . 228)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 237) (:start . 236)\n  (:id . 81))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 245)\n  (:start . 238) (:id . 82))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 255)\n  (:start . 246) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 257) (:start . 256)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "A23187") (:form . "A23187") (:end . 263)\n  (:start . 257) (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 264) (:start . 263)\n  (:id . 86))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 267) (:start . 265)\n  (:id . 87))\n ((:tag . "VB") (:stem . "bypass") (:form . "bypass") (:end . 274)\n  (:start . 268) (:id . 88))\n ((:tag . "JJ") (:stem . "membrane-mediated") (:form . "membrane-mediated")\n  (:end . 292) (:start . 275) (:id . 89))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 302)\n  (:start . 293) (:id . 90))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 309)\n  (:start . 303) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 310) (:start . 309)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s621.4) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005762@unknown@formal@none@1@S@We measured the NF-kappa B binding activity in nuclear extracts by gel shift analysis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s621.5) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005763@unknown@formal@none@1@S@When compared with normal cells, the activation of NF-kappa B activity in SLE patients was significantly decreased in SLE, but not in RA, patients.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "SLE") (:form . "SLE") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x621.6.1) (:span 127 130)))\n (:nscopes ((:id . :x621.6.1) (:span 127 136)))\n (:identifiers (:sid . :s621.6) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005764@unknown@formal@none@1@S@NF-kappa B binding activity was absent in several SLE patients who were not receiving any medication, including corticosteroids.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "sle") (:form . "SLE") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "receive") (:form . "receiving") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "medication") (:form . "medication") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 127) (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x621.7.1) (:span 72 75)) ((:id . :x621.7.2) (:span 32 38)))\n (:nscopes ((:id . :x621.7.1) (:span 72 127))\n  ((:id . :x621.7.2) (:span 0 127)))\n (:identifiers (:sid . :s621.7) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005765@unknown@formal@none@1@S@Also, NF-kappa B activity remained absent in follow-up studies.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "follow-up") (:form . "follow-up") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x621.8.1) (:span 35 41)))\n (:nscopes ((:id . :x621.8.1) (:span 6 62)))\n (:identifiers (:sid . :s621.8) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005766@unknown@formal@none@1@S@In supershift experiments using specific Abs, we showed that, in the group of SLE patients who displayed undetectable NF-kappa B activity, p65 complexes were not formed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sle") (:form . "SLE") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 117)\n  (:start . 105) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 168)\n  (:start . 162) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x621.9.1) (:span 158 161)))\n (:nscopes ((:id . :x621.9.1) (:span 139 168)))\n (:identifiers (:sid . :s621.9) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005767@unknown@formal@none@1@S@Finally, immunoblot analysis of nuclear extracts showed decreased or absent p65 protein levels.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "immunoblot") (:form . "immunoblot") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 55) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x621.10.1) (:span 69 75)))\n (:nscopes ((:id . :x621.10.1) (:span 69 94)))\n (:identifiers (:sid . :s621.10) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005768@unknown@formal@none@1@S@As p65 complexes are transcriptionally active in comparison to the p50 homodimer, this novel finding may provide insight on the origin of abnormal cytokine or other gene transcription in SLE patients.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 38) (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 164)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 183) (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "NN") (:stem . "sle") (:form . "SLE") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 199)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x621.11.1) (:span 156 158))\n  ((:id . :x621.11.2) (:span 101 104)))\n (:hscopes ((:id . :x621.11.1) (:span 147 164))\n  ((:id . :x621.11.2) (:span 101 199)))\n (:identifiers (:sid . :s621.11) (:did . :|10415075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005770@unknown@formal@none@1@S@Different glucocorticoid hormones (GCH) show differences in the intensity and in the kinetics of their immunomodulating activity.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 33)\n  (:start . 25) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GCH") (:form . "GCH") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "intensity") (:form . "intensity") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 102)\n  (:start . 97) (:id . 58))\n ((:tag . "JJ") (:stem . "immunomodulating") (:form . "immunomodulating")\n  (:end . 119) (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s622.2) (:did . :|10415609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005771@unknown@formal@none@1@S@The mechanism(s) of action of GCH is under investigation, but is has been noted that they exert immune activity via the genomic pathway.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GCH") (:form . "GCH") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 127)\n  (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s622.3) (:did . :|10415609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005772@unknown@formal@none@1@S@We have studied the effects of prednisone (PDN), deflazacort (DFC), and dexamethasone (DXM) on the production of cytokines (IL-2, IL-6, TNF-alpha, IL-10) by peripheral T lymphocytes, and the effects on the inhibition of NF-kB DNA binding activity by activated Jurkat cell line.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "prednisone") (:form . "prednisone") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . 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"binding") (:end . 237)\n  (:start . 230) (:id . 91))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 246)\n  (:start . 238) (:id . 92))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 249) (:start . 247)\n  (:id . 93))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 259)\n  (:start . 250) (:id . 94))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 266)\n  (:start . 260) (:id . 95))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 271) (:start . 267)\n  (:id . 96))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 276) (:start . 272)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 98)))@@@1@57@((:identifiers (:sid . :s622.4) (:did . :|10415609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005773@unknown@formal@none@1@S@The data obtained show that the three GCH molecules exert an immunosuppression on cytokine production by T lymphocytes and a strong decrease in the nuclear translocation of NF-kB in Jurkat cells; moreover, (a) not all the cytokines investigated were affected, and not with the same intensity, by the three GCH and (b) DXM inhibited the binding activity of NF-kB less than that of DFC and PDN.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . 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5005774@unknown@formal@none@1@S@These data are in agreement with the concept that different GCH compounds might differ in their binding and affinity properties, tissue-specific metabolism, and interaction with transcription factor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "concept") (:form . "concept") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "NNP") (:stem . "GCH") (:form . "GCH") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 95)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 144) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 172)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 198)\n  (:start . 192) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x622.6.1) (:span 74 79)))\n (:hscopes ((:id . :x622.6.1) (:span 74 198)))\n (:identifiers (:sid . :s622.6) (:did . :|10415609|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005775@unknown@formal@none@1@S@The p53 paradox in the pathogenesis of tumor progression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paradox") (:form . "paradox") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s623.1) (:did . :|10416957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005776@unknown@formal@none@1@S@Recent evidence suggests that the p53 molecule appears in two different forms: the mutant p53 that stimulates tumor progression, and wild type p53 that inhibits tumor progression.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 178)\n  (:start . 167) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x623.2.1) (:span 16 24)))\n (:hscopes ((:id . :x623.2.1) (:span 16 178)))\n (:identifiers (:sid . :s623.2) (:did . :|10416957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005777@unknown@formal@none@1@S@In addition, it has been established that tumor necrosis factor-alpha (TNF-alpha) can activate the expression of wild type p53 in concert with the nuclear transcription factor, NF-kappa B.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 69)\n  (:start . 57) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 175)\n  (:start . 169) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 185)\n  (:start . 177) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s623.3) (:did . :|10416957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005778@unknown@formal@none@1@S@Both TNF-alpha and NF-kappa B are also involved in the stimulation of the pathway that leads to the expression of major histocompatibility complex (MHC) class I molecules and, hence, antigen presentation to the T cells.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 138) (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 72))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 181)\n  (:start . 176) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 190)\n  (:start . 183) (:id . 75))\n ((:tag . "NN") (:stem . "presentation") (:form . "presentation") (:end . 203)\n  (:start . 191) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 206) (:start . 204)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 212) (:start . 211)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s623.4) (:did . :|10416957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005780@unknown@formal@none@1@S@Thus, it is hypothesized that elevated TNF-alpha is primarily responsible for promoting tumor progression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "hypothesize") (:form . "hypothesized") (:end . 24)\n  (:start . 12) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "promote") (:form . "promoting") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x623.6.1) (:span 12 24)))\n (:hscopes ((:id . :x623.6.1) (:span 12 105)))\n (:identifiers (:sid . :s623.6) (:did . :|10416957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005781@unknown@formal@none@1@S@Stimulation of neutrophil interleukin-8 production by eosinophil granule major basic protein.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 39) (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 64)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 72)\n  (:start . 65) (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 78) (:start . 73)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 84) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s624.1) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005782@unknown@formal@none@1@S@We evaluated the ability of eosinophil granule major basic protein (MBP) to stimulate interleukin (IL)-8 production by neutrophils.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "CD") (:stem . "IL)-8") (:form . "IL)-8") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s624.2) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005783@unknown@formal@none@1@S@MBP over the concentration range of 0.1 to 10 microM stimulated the release of up to approximately 8 ng/ml IL-8.@(((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 98) (:start . 85) (:id . 58))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s624.3) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005784@unknown@formal@none@1@S@Incubation with 2 microM MBP showed that, after a 1 h lag, the level of IL-8 release increased with time for approximately 10 h.@(((:tag . "NNP") (:stem . "Incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lag") (:form . "lag") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 68) (:start . 63)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 76) (:start . 72)\n  (:id . 59))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 84)\n  (:start . 77) (:id . 60))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 94)\n  (:start . 85) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 62))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 104) (:start . 100)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 122) (:start . 109) (:id . 65))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 127) (:start . 126)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s624.4) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005785@unknown@formal@none@1@S@At the 2 microM concentration, eosinophil cationic protein, eosinophil-derived neurotoxin, and eosinophil peroxidase did not stimulate significant levels of IL-8 production.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 29) (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "cationic") (:form . "cationic") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "eosinophil-derived") (:form . "eosinophil-derived")\n  (:end . 78) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "neurotoxin") (:form . "neurotoxin") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "peroxidase") (:form . "peroxidase") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 146)\n  (:start . 135) (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 153)\n  (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 161) (:start . 157)\n  (:id . 64))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 172)\n  (:start . 162) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x624.5.1) (:span 121 124)))\n (:nscopes ((:id . :x624.5.1) (:span 121 172)))\n (:identifiers (:sid . :s624.5) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005786@unknown@formal@none@1@S@MBP stimulated 2-fold increases in IL-8 messenger RNA (mRNA) after 1 and 3 h of incubation, which were blocked by pretreatment with actinomycin D.@(((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "2-fold") (:form . "2-fold") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 90)\n  (:start . 80) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 102) (:start . 98)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 110)\n  (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 126)\n  (:start . 114) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 143)\n  (:start . 132) (:id . 67))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 145) (:start . 144)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s624.6) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005787@unknown@formal@none@1@S@However, stimulation with MBP did not produce an increase in the binding activity of nuclear factor (NF)-kappaB or activator protein-1.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x624.7.1) (:span 34 37)))\n (:nscopes ((:id . :x624.7.1) (:span 34 134)))\n (:identifiers (:sid . :s624.7) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005788@unknown@formal@none@1@S@No NF-IL-6 binding activity was detected in the same nuclear extracts.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nf-il-6") (:form . "NF-IL-6") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s624.8) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005790@unknown@formal@none@1@S@MBP also induced transient increases in mRNA for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta, but did not stimulate the release of either chemokine.@(((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MIP)-1alpha") (:form . "MIP)-1alpha") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MIP-1beta") (:form . "MIP-1beta") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 152)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 162)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x624.10.1) (:span 117 120)))\n (:nscopes ((:id . :x624.10.1) (:span 117 162)))\n (:identifiers (:sid . :s624.10) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005791@unknown@formal@none@1@S@These findings indicate that MBP is selective among the eosinophil granule proteins as a stimulus for neutrophil IL-8 release and, further, that stimulation of neutrophil IL-8 release by MBP involves both transcriptional and posttranscriptional regulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 199)\n  (:start . 191) (:id . 73))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 220) (:start . 205) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 244) (:start . 225) (:id . 77))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 255)\n  (:start . 245) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x624.11.1) (:span 15 28)))\n (:hscopes ((:id . :x624.11.1) (:span 15 255)))\n (:identifiers (:sid . :s624.11) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005792@unknown@formal@none@1@S@We postulate that MBP-induced release of IL-8 by neutrophils may contribute to the pathophysiology of acute asthma and other inflammatory lung diseases.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "postulate") (:form . "postulate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mbp-induced") (:form . "MBP-induced") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 98) (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 137)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x624.12.1) (:span 61 64)))\n (:hscopes ((:id . :x624.12.1) (:span 61 151)))\n (:identifiers (:sid . :s624.12) (:did . :|10423406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005793@unknown@formal@none@1@S@PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.@(((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adipocyte") (:form . "adipocyte") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s625.1) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005794@unknown@formal@none@1@S@The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "peroxisome-proliferator")\n  (:form . "peroxisome-proliferator") (:end . 27) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "activated") (:form . "activated") (:end . 37)\n  (:start . 28) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 46)\n  (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 52) (:start . 47)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 152)\n  (:start . 145) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "anti-diabetic") (:form . "anti-diabetic")\n  (:end . 191) (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 199)\n  (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "thiazolidinedione") (:form . "thiazolidinediones")\n  (:end . 225) (:start . 207) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TZD") (:form . "TZDs") (:end . 231) (:start . 227)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s625.2) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005795@unknown@formal@none@1@S@PPARgamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation.@(((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "anabolism") (:form . "anabolism") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adipocyte") (:form . "adipocyte") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap2") (:form . "aP2") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 156)\n  (:start . 147) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "adipocyte") (:form . "adipocyte") (:end . 169)\n  (:start . 160) (:id . 71))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 185) (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s625.3) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005796@unknown@formal@none@1@S@PPARgamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages.@(((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 105) (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s625.4) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005797@unknown@formal@none@1@S@Activation of PPARgamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 75) (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "foam") (:form . "foam") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 145) (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 153)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x625.5.1) (:span 24 27)))\n (:hscopes ((:id . :x625.5.1) (:span 24 153)))\n (:identifiers (:sid . :s625.5) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005798@unknown@formal@none@1@S@We report that both natural and synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "time-") (:form . "time-") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 92) (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap2") (:form . "aP2") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s625.6) (:did . :|10425206|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005800@unknown@formal@none@1@S@Reactive oxygen intermediate-release of fibre-exposed monocytes increases inflammatory cytokine-mRNA level, protein tyrosine kinase and NF-kappaB activity in co-cultured bronchial epithelial cells (BEAS-2B).@(((:tag . "JJ") (:stem . "reactive") (:form . "Reactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "intermediate-release")\n  (:form . "intermediate-release") (:end . 36) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "fibre-exposed") (:form . "fibre-exposed")\n  (:end . 53) (:start . 40) (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 63)\n  (:start . 54) (:id . 47))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 73)\n  (:start . 64) (:id . 48))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 86)\n  (:start . 74) (:id . 49))\n ((:tag . "NN") (:stem . "cytokine-mrna") (:form . "cytokine-mRNA")\n  (:end . 100) (:start . 87) (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 106)\n  (:start . 101) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 124)\n  (:start . 116) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 131)\n  (:start . 125) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 145)\n  (:start . 136) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 154)\n  (:start . 146) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "co-culture") (:form . "co-cultured") (:end . 169)\n  (:start . 158) (:id . 60))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 179)\n  (:start . 170) (:id . 61))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 190)\n  (:start . 180) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "BEAS-2B") (:form . "BEAS-2B") (:end . 205)\n  (:start . 198) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s626.1) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005801@unknown@formal@none@1@S@Some pulmonary diseases like bronchitis or asthma bronchiale are mediated by inflammatory mechanisms in bronchial epithelial cells.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bronchitis") (:form . "bronchitis") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "bronchiale") (:form . "bronchiale") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 124)\n  (:start . 114) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s626.2) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005802@unknown@formal@none@1@S@Alveolar macrophages are located directly in the surrounding of these cells, so that we suppose an interaction between epithelial cells and macrophages regarding to the release of inflammatory mediators.@(((:tag . "JJ") (:stem . "alveolar") (:form . "Alveolar") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "surrounding") (:form . "surrounding") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "so") (:form . "so") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "suppose") (:form . "suppose") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 110)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "VBG") (:stem . "regard") (:form . "regarding") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 192)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 202)\n  (:start . 193) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x626.3.1) (:span 88 95)))\n (:hscopes ((:id . :x626.3.1) (:span 88 202)))\n (:identifiers (:sid . :s626.3) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005803@unknown@formal@none@1@S@For measuring the contribution of macrophages to the release of inflammatory mediators by bronchial epithelial cells, we established an in vitro model of co-cultured blood monocytes (BM) and BEAS-2B cells in a transwell system (Costar).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "measure") (:form . "measuring") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 76)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 132)\n  (:start . 121) (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "co-culture") (:form . "co-cultured") (:end . 165)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "BM") (:form . "BM") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "BEAS-2B") (:form . "BEAS-2B") (:end . 198)\n  (:start . 191) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transwell") (:form . "transwell") (:end . 219)\n  (:start . 210) (:id . 77))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 226)\n  (:start . 220) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 228) (:start . 227)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Costar") (:form . "Costar") (:end . 234)\n  (:start . 228) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 235) (:start . 234)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s626.4) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005804@unknown@formal@none@1@S@BM were exposed to Chrysotile B and soot particle FR 101 in a concentration of 100 microg/10(6) cells.@(((:tag . "NNP") (:stem . "BM") (:form . "BM") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Chrysotile") (:form . "Chrysotile") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "soot") (:form . "soot") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "particle") (:form . "particle") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "FR") (:form . "FR") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "101") (:form . "101") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 75) (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "microg/10(6)") (:form . "microg/10(6)") (:end . 95)\n  (:start . 83) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s626.5) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005805@unknown@formal@none@1@S@After up to 90 min exposure time ELISA, EMSA (electromobility shift assay) and RT-PCR were used to measure protein tyrosine kinase activity, protein activity of NF-kappaB and cytokine (IL-1beta, IL-6, TNF-alpha) specific mRNA levels in BEAS-2B cells.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "electromobility") (:form . "electromobility")\n  (:end . 61) (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 85)\n  (:start . 79) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 106)\n  (:start . 99) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 123)\n  (:start . 115) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 148)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 170)\n  (:start . 161) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 183)\n  (:start . 175) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 193)\n  (:start . 185) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 210)\n  (:start . 201) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 211) (:start . 210)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 220)\n  (:start . 212) (:id . 81))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 225) (:start . 221)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 232)\n  (:start . 226) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "BEAS-2B") (:form . "BEAS-2B") (:end . 243)\n  (:start . 236) (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 249)\n  (:start . 244) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s626.6) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005806@unknown@formal@none@1@S@We observed an increase in protein tyrosine kinase activity (up to 1.8 ± 0.5-fold) and NF-kappaB protein activity in BEAS-2B cells after particle or fibre exposure of co-cultured BM.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1.8") (:form . "1.8") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "0.5-fold") (:form . "0.5-fold") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 96)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BEAS-2B") (:form . "BEAS-2B") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "particle") (:form . "particle") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "fibre") (:form . "fibre") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "co-culture") (:form . "co-cultured") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "bm") (:form . "BM") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s626.7) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005807@unknown@formal@none@1@S@Consecutive IL-1beta-, IL-6- and TNF-alpha-mRNA were elevated (up to 1.9 ± 0.58-fold).@(((:tag . "JJ") (:stem . "consecutive") (:form . "Consecutive") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-1beta-") (:form . "IL-1beta-") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6-") (:form . "IL-6-") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha-mRNA") (:form . "TNF-alpha-mRNA")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1.9") (:form . "1.9") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "RB") (:stem . "0.58-fold") (:form . "0.58-fold") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s626.8) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005808@unknown@formal@none@1@S@Protein tyrosine kinase activity, NF-kappaB activity, and the synthesis of cytokine-specific mRNA were inhibited by antioxidants.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytokine-specific") (:form . "cytokine-specific")\n  (:end . 92) (:start . 75) (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 128)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s626.9) (:did . :|10425262|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005810@unknown@formal@none@1@S@Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.@(((:tag . "NNP") (:stem . "Host") (:form . "Host") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 59)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "JJ") (:stem . "toll-like") (:form . "toll-like") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s627.1) (:did . :|10426995|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005811@unknown@formal@none@1@S@The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 98)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-12") (:form . "interleukin-12")\n  (:end . 116) (:start . 102) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 152)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 159)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 166)\n  (:start . 160) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s627.2) (:did . :|10426995|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005812@unknown@formal@none@1@S@Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 23)\n  (:start . 14) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VB") (:stem . "remain") (:form . "remain") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "JJ") (:stem . "undefined") (:form . "undefined") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s627.3) (:did . :|10426995|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005813@unknown@formal@none@1@S@Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "stimulator") (:form . "stimulators") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "toll-like") (:form . "Toll-like") (:end . 153)\n  (:start . 144) (:id . 65))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 163)\n  (:start . 154) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TLR") (:form . "TLRs") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s627.4) (:did . :|10426995|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005814@unknown@formal@none@1@S@Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "JJ") (:stem . "tlr-dependent") (:form . "TLR-dependent")\n  (:end . 45) (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 72)\n  (:start . 63) (:id . 48))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 79)\n  (:start . 73) (:id . 49))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 85) (:start . 80)\n  (:id . 50))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 94)\n  (:start . 86) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 113)\n  (:start . 103) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 123)\n  (:start . 117) (:id . 56))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "JJ") (:stem . "microbicidal") (:form . "microbicidal") (:end . 154)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 162)\n  (:start . 155) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s627.5) (:did . :|10426995|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005815@unknown@formal@none@1@S@Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "tlr") (:form . "TLRs") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 102)\n  (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x627.6.1) (:span 45 48)))\n (:hscopes ((:id . :x627.6.1) (:span 45 112)))\n (:identifiers (:sid . :s627.6) (:did . :|10426995|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005816@unknown@formal@none@1@S@Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "JJ") (:stem . "toll-like") (:form . "toll-like") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "receptor-2") (:form . "receptor-2") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s628.1) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005817@unknown@formal@none@1@S@Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens.@(((:tag . "NNP") (:stem . "Apoptosis") (:form . "Apoptosis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "resolution") (:form . "resolution") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s628.2) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005818@unknown@formal@none@1@S@All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BLP") (:form . "BLPs") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "trigger") (:form . "trigger") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s628.3) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005820@unknown@formal@none@1@S@BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2.@(((:tag . "NNP") (:stem . "BLP") (:form . "BLPs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "initiate") (:form . "initiated") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "htlr2") (:form . "hTLR2") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s628.5) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005821@unknown@formal@none@1@S@In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "blp") (:form . "BLPs") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 69) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 141)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "htlr2") (:form . "hTLR2") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s628.6) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005822@unknown@formal@none@1@S@Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "htlr2") (:form . "hTLR2") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 26)\n  (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s628.7) (:did . :|10426996|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005823@unknown@formal@none@1@S@Tissue-specific regulation of the ecto-5'-nucleotidase promoter.@(((:tag . "JJ") (:stem . "tissue-specific") (:form . "Tissue-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ecto-5'-nucleotidase")\n  (:form . "ecto-5'-nucleotidase") (:end . 54) (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s629.1) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005824@unknown@formal@none@1@S@Role of the camp response element site in mediating repression by the upstream regulatory region.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "camp") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s629.2) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005825@unknown@formal@none@1@S@We have isolated the 5' region of the ecto-5'-nucleotidase (low K(m) 5'-NT) gene and established that a 969-base pair (bp) fragment confers cell-specific expression of a CAT reporter gene that correlates with the expression of endogenous ecto-5'-NT mRNA and enzymatic activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 30)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ecto-5'-nucleotidase")\n  (:form . "ecto-5'-nucleotidase") (:end . 58) (:start . 38) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "K(m)") (:form . "K(m)") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "5'-nt") (:form . "5'-NT") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 96)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "969-base") (:form . "969-base") (:end . 112)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 131)\n  (:start . 123) (:id . 67))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 139)\n  (:start . 132) (:id . 68))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 153) (:start . 140) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 164)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 203)\n  (:start . 193) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 208) (:start . 204)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 223)\n  (:start . 213) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 237)\n  (:start . 227) (:id . 82))\n ((:tag . "JJ|NN") (:stem . "ecto-5'-nt") (:form . "ecto-5'-NT") (:end . 248)\n  (:start . 238) (:id . 83))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 253) (:start . 249)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 257) (:start . 254)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 267)\n  (:start . 258) (:id . 86))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 276)\n  (:start . 268) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s629.3) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005826@unknown@formal@none@1@S@A 768-bp upstream negative regulatory region has been identified that conferred lymphocyte-specific negative regulation in a heterologous system with a 244-bp deoxycytidine kinase core promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "768-bp") (:form . "768-bp") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 99) (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 108)\n  (:start . 100) (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 119)\n  (:start . 109) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 137)\n  (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 144)\n  (:start . 138) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 149) (:start . 145)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "244-bp") (:form . "244-bp") (:end . 158)\n  (:start . 152) (:id . 62))\n ((:tag . "NN") (:stem . "deoxycytidine") (:form . "deoxycytidine")\n  (:end . 172) (:start . 159) (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 179)\n  (:start . 173) (:id . 64))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 184) (:start . 180)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 193)\n  (:start . 185) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s629.4) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005827@unknown@formal@none@1@S@DNase I footprinting identified several protected areas including Sp1, Sp1/AP-2, and cAMP response element (CRE) binding sites within the 201-bp core promoter region and Sp1, NRE-2a, TCF-1/LEF-1, and Sp1/NF-AT binding sites in the upstream regulatory region.@(((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "protected") (:form . "protected") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sp1/ap-2") (:form . "Sp1/AP-2") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "201-bp") (:form . "201-bp") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 173) (:start . 170)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NRE-2a") (:form . "NRE-2a") (:end . 181)\n  (:start . 175) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TCF-1/LEF-1") (:form . "TCF-1/LEF-1") (:end . 194)\n  (:start . 183) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Sp1/NF-AT") (:form . "Sp1/NF-AT") (:end . 209)\n  (:start . 200) (:id . 77))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 217)\n  (:start . 210) (:id . 78))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 223)\n  (:start . 218) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 239)\n  (:start . 231) (:id . 82))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 250)\n  (:start . 240) (:id . 83))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 257)\n  (:start . 251) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s629.5) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005828@unknown@formal@none@1@S@Whereas the CRE site was essential in mediating the negative activity of the upstream regulatory region in Jurkat but not in HeLa cells, mutation of the Sp1/AP-2 site decreased promoter activity in both cell lines.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sp1/ap-2") (:form . "Sp1/AP-2") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 176)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 185)\n  (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 202) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 207) (:start . 203)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 213)\n  (:start . 208) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x629.6.1) (:span 118 121)))\n (:nscopes ((:id . :x629.6.1) (:span 118 135)))\n (:identifiers (:sid . :s629.6) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005830@unknown@formal@none@1@S@Finally, phorbol 12-myristate 13-acetate increased the activity of both the core and the 969-bp promoter fragments, and this increase was abrogated by mutations at the CRE site.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "969-bp") (:form . "969-bp") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 160)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s629.8) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005831@unknown@formal@none@1@S@In summary, we have identified a tissue-specific regulatory region 5' of the ecto-5'-NT core promoter that requires the presence of a functional CRE site within the basal promoter for its suppressive activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 48) (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ|NN") (:stem . "ecto-5'-nt") (:form . "ecto-5'-NT") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "cre") (:form . "CRE") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 160)\n  (:start . 154) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 183) (:start . 180)\n  (:id . 72))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 199)\n  (:start . 188) (:id . 74))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 208)\n  (:start . 200) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s629.9) (:did . :|10428853|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005832@unknown@formal@none@1@S@NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.@(((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 32) (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Bcl-x") (:form . "Bcl-x") (:end . 41) (:start . 36)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Bfl-1/A1") (:form . "Bfl-1/A1") (:end . 54)\n  (:start . 46) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 111)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s630.1) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005833@unknown@formal@none@1@S@Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "thymus-dependent") (:form . "thymus-dependent")\n  (:end . 52) (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "humoral") (:form . "humoral") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "rescue") (:form . "rescuing") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s630.2) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005834@unknown@formal@none@1@S@Many of the effects of CD40 are believed to be achieved through altered gene expression.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x630.3.1) (:span 32 40)))\n (:hscopes ((:id . :x630.3.1) (:span 0 87)))\n (:identifiers (:sid . :s630.3) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005835@unknown@formal@none@1@S@In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Bcl-x") (:form . "Bcl-x") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd40-regulated") (:form . "CD40-regulated")\n  (:end . 44) (:start . 30) (:id . 49))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 106) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "A1/Bfl-1") (:form . "A1/Bfl-1") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cd40-inducible") (:form . "CD40-inducible")\n  (:end . 146) (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s630.4) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005836@unknown@formal@none@1@S@Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 53) (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dominant-active") (:form . "dominant-active")\n  (:end . 74) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "JJ") (:stem . "cd40-induced") (:form . "CD40-induced") (:end . 120)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 134) (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 142) (:start . 138)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "bfl-1") (:form . "Bfl-1") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Bcl-x") (:form . "Bcl-x") (:end . 162)\n  (:start . 157) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 168)\n  (:start . 163) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "eliminate") (:form . "eliminated") (:end . 188)\n  (:start . 178) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 200)\n  (:start . 193) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 208) (:start . 204)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 72))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 218)\n  (:start . 212) (:id . 73))\n ((:tag . "JJ") (:stem . "fas-induced") (:form . "Fas-induced") (:end . 230)\n  (:start . 219) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 235) (:start . 231)\n  (:id . 75))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 241)\n  (:start . 236) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s630.5) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005837@unknown@formal@none@1@S@Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Bcl-x") (:form . "Bcl-x") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 75) (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 125) (:start . 106) (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 141) (:start . 126) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 152)\n  (:start . 142) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s630.6) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005838@unknown@formal@none@1@S@Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Bcl-x") (:form . "Bcl-x") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "protect") (:form . "protected") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 92)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x630.7.1) (:span 110 117)))\n (:nscopes ((:id . :x630.7.1) (:span 110 140)))\n (:identifiers (:sid . :s630.7) (:did . :|10430908|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005840@unknown@formal@none@1@S@Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.@(((:tag . "JJ") (:stem . "distinctive") (:form . "Distinctive") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "cancer") (:form . "cancers") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s631.1) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005841@unknown@formal@none@1@S@cDNA microarrays and a clustering algorithm were used to identify patterns of gene expression in human mammary epithelial cells growing in culture and in primary human breast tumors.@(((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "microarray") (:form . "microarrays") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "clustering") (:form . "clustering") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 174)\n  (:start . 168) (:id . 68))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 181)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s631.2) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005842@unknown@formal@none@1@S@Clusters of coexpressed genes identified through manipulations of mammary epithelial cells in vitro also showed consistent patterns of variation in expression among breast tumor samples.@(((:tag . "NNS") (:stem . "cluster") (:form . "Clusters") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "manipulation") (:form . "manipulations")\n  (:end . 62) (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 131)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 59))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 144)\n  (:start . 135) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 62))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 164)\n  (:start . 159) (:id . 63))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 171)\n  (:start . 165) (:id . 64))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 177)\n  (:start . 172) (:id . 65))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 185)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s631.3) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005843@unknown@formal@none@1@S@By using immunohistochemistry with antibodies against proteins encoded by a particular gene in a cluster, the identity of the cell type within the tumor specimen that contributed the observed gene expression pattern could be determined.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 29) (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 70)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 142)\n  (:start . 136) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "specimen") (:form . "specimen") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "contribute") (:form . "contributed") (:end . 178)\n  (:start . 167) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 191)\n  (:start . 183) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 207)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 215)\n  (:start . 208) (:id . 74))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 221)\n  (:start . 216) (:id . 75))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 224) (:start . 222)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 235)\n  (:start . 225) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s631.4) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005844@unknown@formal@none@1@S@Clusters of genes with coherent expression patterns in cultured cells and in the breast tumors samples could be related to specific features of biological variation among the samples.@(((:tag . "NNS") (:stem . "cluster") (:form . "Clusters") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "coherent") (:form . "coherent") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 182)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s631.5) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005845@unknown@formal@none@1@S@Two such clusters were found to have patterns that correlated with variation in cell proliferation rates and with activation of the IFN-regulated signal transduction pathway, respectively.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 98) (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ifn-regulated") (:form . "IFN-regulated")\n  (:end . 145) (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 152)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 165)\n  (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 187)\n  (:start . 175) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s631.6) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005846@unknown@formal@none@1@S@Clusters of genes expressed by stromal cells and lymphocytes in the breast tumors also were identified in this analysis.@(((:tag . "NNS") (:stem . "cluster") (:form . "Clusters") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "stromal") (:form . "stromal") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s631.7) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005847@unknown@formal@none@1@S@These results support the feasibility and usefulness of this systematic approach to studying variation in gene expression patterns in human cancers as a means to dissect and classify solid tumors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "feasibility") (:form . "feasibility") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "usefulness") (:form . "usefulness") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "systematic") (:form . "systematic") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "cancer") (:form . "cancers") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "means") (:form . "means") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "VB") (:stem . "dissect") (:form . "dissect") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "VB") (:stem . "classify") (:form . "classify") (:end . 182)\n  (:start . 174) (:id . 69))\n ((:tag . "JJ") (:stem . "solid") (:form . "solid") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 195)\n  (:start . 189) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s631.8) (:did . :|10430922|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005848@unknown@formal@none@1@S@Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription.@(((:tag . "JJ") (:stem . "bcl-2-mediated") (:form . "Bcl-2-mediated")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 19) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT)-induced") (:form . "NFAT)-induced")\n  (:end . 124) (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s632.1) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005850@unknown@formal@none@1@S@It is generally accepted that Bcl-2 exerts its antiapoptotic effects mainly by dimerizing with proapoptotic members of the Bcl-2 family such as Bax and Bad.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "VBN") (:stem . "accept") (:form . "accepted") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "dimerize") (:form . "dimerizing") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proapoptotic") (:form . "proapoptotic") (:end . 107)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Bax") (:form . "Bax") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Bad") (:form . "Bad") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s632.3) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005851@unknown@formal@none@1@S@However, the mechanism of the antiapoptotic effects is unclear.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antiapoptotic") (:form . "antiapoptotic")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x632.4.1) (:span 55 62)))\n (:hscopes ((:id . :x632.4.1) (:span 9 62)))\n (:identifiers (:sid . :s632.4) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005852@unknown@formal@none@1@S@Paclitaxel and other drugs that disturb microtubule dynamics kill cells in a Fas/Fas ligand (FasL)-dependent manner; antibody to FasL inhibits paclitaxel-induced apoptosis.@(((:tag . "NNP") (:stem . "Paclitaxel") (:form . "Paclitaxel") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "disturb") (:form . "disturb") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "microtubule") (:form . "microtubule") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "dynamic") (:form . "dynamics") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "VBP") (:stem . "kill") (:form . "kill") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Fas/Fas") (:form . "Fas/Fas") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FasL)-dependent") (:form . "FasL)-dependent")\n  (:end . 108) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "paclitaxel-induced") (:form . "paclitaxel-induced")\n  (:end . 161) (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s632.5) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005853@unknown@formal@none@1@S@We have found that Bcl-2 overexpression leads to the prevention of chemotherapy (paclitaxel)-induced expression of FasL and blocks paclitaxel-induced apoptosis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chemotherapy") (:form . "chemotherapy") (:end . 79)\n  (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "paclitaxel)-induced")\n  (:form . "paclitaxel)-induced") (:end . 100) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "paclitaxel-induced") (:form . "paclitaxel-induced")\n  (:end . 149) (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 159)\n  (:start . 150) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s632.6) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005854@unknown@formal@none@1@S@The mechanism of this effect is that Bcl-2 prevents the nuclear translocation of NFAT (nuclear factor of activated T lymphocytes, a transcription factor activated by microtubule damage) by binding and sequestering calcineurin, a calcium-dependent phosphatase that must dephosphorylate NFAT to move to the nucleus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . 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"by") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "microtubule") (:form . "microtubule") (:end . 177)\n  (:start . 166) (:id . 69))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 196)\n  (:start . 189) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "sequester") (:form . "sequestering") (:end . 213)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 225)\n  (:start . 214) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . 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5005855@unknown@formal@none@1@S@Without NFAT nuclear translocation, the FasL gene is not transcribed.@(((:tag . "IN") (:stem . "without") (:form . "Without") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x632.8.1) (:span 53 56)) ((:id . :x632.8.2) (:span 0 7)))\n (:nscopes ((:id . :x632.8.1) (:span 36 68)) ((:id . :x632.8.2) (:span 0 34)))\n (:identifiers (:sid . :s632.8) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005856@unknown@formal@none@1@S@Thus, it appears that paclitaxel and other drugs that disturb microtubule function kill cells at least in part through the induction of FasL.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "paclitaxel") (:form . "paclitaxel") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "disturb") (:form . "disturb") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "microtubule") (:form . "microtubule") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "kill") (:form . "kill") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 102)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x632.9.1) (:span 9 16)))\n (:hscopes ((:id . :x632.9.1) (:span 9 140)))\n (:identifiers (:sid . :s632.9) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005857@unknown@formal@none@1@S@Furthermore, Bcl-2 antagonizes drug-induced apoptosis by inhibiting calcineurin activation, blocking NFAT nuclear translocation, and preventing FasL expression.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "antagonize") (:form . "antagonizes") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "drug-induced") (:form . "drug-induced") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 79)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 100)\n  (:start . 92) (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 113)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 127) (:start . 114) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 143)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "fasl") (:form . "FasL") (:end . 148) (:start . 144)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s632.10) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005858@unknown@formal@none@1@S@The effects of Bcl-2 can be overcome, at least partially, through phosphorylation of Bcl-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "overcome") (:form . "overcome") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 81) (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s632.11) (:did . :|10432288|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005860@unknown@formal@none@1@S@Retinoblastoma protein expression leads to reduced Oct-1 DNA binding activity and enhances interleukin-8 expression.@(((:tag . "NN") (:stem . "retinoblastoma") (:form . "Retinoblastoma")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 44))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 39) (:start . 34)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 104) (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s633.1) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005861@unknown@formal@none@1@S@Tumor cell lines with a defective retinoblastoma gene are unable to transcribe the HLA class II genes in response to IFN-gamma treatment, and reconstitution of functional Rb rescues IFN-gamma-induced class II gene expression.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 48) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VB") (:stem . "transcribe") (:form . "transcribe") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "reconstitution") (:form . "reconstitution")\n  (:end . 156) (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "rescue") (:form . "rescues") (:end . 181)\n  (:start . 174) (:id . 70))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 199) (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 205)\n  (:start . 200) (:id . 72))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 213) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 224)\n  (:start . 214) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x633.2.1) (:span 58 64)))\n (:nscopes ((:id . :x633.2.1) (:span 0 136)))\n (:identifiers (:sid . :s633.2) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005862@unknown@formal@none@1@S@However, the molecular mechanism of Rb rescue of the class II genes is unknown.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x633.3.1) (:span 71 78)))\n (:hscopes ((:id . :x633.3.1) (:span 9 78)))\n (:identifiers (:sid . :s633.3) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005863@unknown@formal@none@1@S@We have examined the effect of Rb expression on the activation of the promoter for HLA-DRA, the prototype class II gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "prototype") (:form . "prototype") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s633.4) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005864@unknown@formal@none@1@S@Oct-1, a POU domain transcription factor, was identified as a repressor of HLA-DRA promoter activity in the Rb-defective cells.@(((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 19)\n  (:start . 13) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 33) (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "rb-defective") (:form . "Rb-defective") (:end . 120)\n  (:start . 108) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s633.5) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005865@unknown@formal@none@1@S@Rb expression led to phosphorylation of Oct-1, thus relieving its repressive effect.@(((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 36) (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "relieve") (:form . "relieving") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s633.6) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005866@unknown@formal@none@1@S@Oct-1 has also been shown to repress interleukin 8 promoter activity.@(((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s633.7) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005867@unknown@formal@none@1@S@Consistent with reduced levels of Oct-1 DNA binding activity in the Rb-transformed cell lines, interleukin 8 expression is higher in these cell lines.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rb-transformed") (:form . "Rb-transformed")\n  (:end . 82) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 106)\n  (:start . 95) (:id . 57))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s633.8) (:did . :|10437913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005868@unknown@formal@none@1@S@Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s634.1) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005870@unknown@formal@none@1@S@T cell receptor (TCR) cross-linking is in part required for activation of NF-kappaB, which is dependent on the phosphorylation and degradation of IkappaBalpha.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 35) (:start . 22) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 103)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 126) (:start . 111) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 142)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 158) (:start . 146) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s634.3) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005871@unknown@formal@none@1@S@By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 15)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . 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"kinase") (:end . 178)\n  (:start . 172) (:id . 68))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 202)\n  (:start . 191) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 75))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 211)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 78))\n ((:tag . 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"but") (:form . "but") (:end . 286) (:start . 283)\n  (:id . 89))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 290) (:start . 287)\n  (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 293) (:start . 291)\n  (:id . 91))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 301)\n  (:start . 294) (:id . 92))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 310)\n  (:start . 302) (:id . 93))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 323) (:start . 311) (:id . 94))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 330)\n  (:start . 324) (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 331) (:start . 330)\n  (:id . 96))\n ((:tag . "NNP") (:stem . "p90(rsk)") (:form . "p90(rsk)") (:end . 340)\n  (:start . 332) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5005872@unknown@formal@none@1@S@We also demonstrate that the IKK complex, but not p90(rsk), is responsible for the in vivo phosphorylation of IkappaBalpha mediated by the co-activation of PKC and calcineurin.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "p90(rsk)") (:form . "p90(rsk)") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 74)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 106) (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 122) (:start . 110) (:id . 62))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "co-activation") (:form . "co-activation")\n  (:end . 152) (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 175)\n  (:start . 164) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x634.5.1) (:span 46 49)))\n (:nscopes ((:id . :x634.5.1) (:span 46 58)))\n (:identifiers (:sid . :s634.5) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005873@unknown@formal@none@1@S@Each second messenger is necessary, as inhibition of either one reverses the activation of the IKK complex and IkappaBalpha phosphorylation in vivo.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "one") (:form . "one") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "reverse") (:form . "reverses") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 123) (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 139) (:start . 124) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s634.6) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005874@unknown@formal@none@1@S@Overexpression of dominant negative forms of IKKalpha and -beta demonstrates that only IKKbeta is the target for PKC and calcineurin.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s634.7) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005875@unknown@formal@none@1@S@These results indicate that within the TCR/CD3 signal transduction pathway both PKC and calcineurin are required for the effective activation of the IKK complex and NF-kappaB in T lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tcr/cd3") (:form . "TCR/CD3") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 174)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 191)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x634.8.1) (:span 14 27)))\n (:hscopes ((:id . :x634.8.1) (:span 14 191)))\n (:identifiers (:sid . :s634.8) (:did . :|10438457|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005876@unknown@formal@none@1@S@C/EBPbeta and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: implication for C/EBPbeta activity in eosinophil gene expression.@(((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 36) (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 92) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "implication") (:form . "implication") (:end . 122)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 136)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 145)\n  (:start . 137) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s635.1) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005877@unknown@formal@none@1@S@Eosinophil granule major basic protein (MBP) is expressed exclusively in eosinophils and basophils in hematopoietic cells.@(((:tag . "NNP") (:stem . "Eosinophil") (:form . "Eosinophil") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "granule") (:form . "granule") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "basophil") (:form . "basophils") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s635.2) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005878@unknown@formal@none@1@S@In our previous study, we demonstrated a major positive regulatory role for GATA-1 and a negative regulatory role for GATA-2 in MBP gene transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 150) (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s635.3) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005880@unknown@formal@none@1@S@In the cell line HT93A, which is capable of differentiating towards both the eosinophil and neutrophil lineages in response to retinoic acid (RA), C/EBPalpha mRNA expression decreased significantly concomitant with eosinophilic and neutrophilic differentiation, whereas C/EBPbeta expression was markedly increased.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HT93A") (:form . "HT93A") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 40)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 59) (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "C/EBPalpha") (:form . "C/EBPalpha") (:end . 157)\n  (:start . 147) (:id . 69))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 162) (:start . 158)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 71))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 183)\n  (:start . 174) (:id . 72))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 197) (:start . 184) (:id . 73))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 209)\n  (:start . 198) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 214) (:start . 210)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 227)\n  (:start . 215) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "neutrophilic") (:form . "neutrophilic") (:end . 244)\n  (:start . 232) (:id . 78))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 260) (:start . 245) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 261) (:start . 260)\n  (:id . 80))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 269)\n  (:start . 262) (:id . 81))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 279)\n  (:start . 270) (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 290)\n  (:start . 280) (:id . 83))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 294) (:start . 291)\n  (:id . 84))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 303)\n  (:start . 295) (:id . 85))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 313)\n  (:start . 304) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 314) (:start . 313)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s635.5) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005881@unknown@formal@none@1@S@Electrophoretic mobility shift assays (EMSAs) showed that recombinant C/EBPbeta protein could bind to the potential C/EBP-binding site (bp -90 to -82) in the MBP promoter.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 52) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "JJ") (:stem . "c/ebp-binding") (:form . "C/EBP-binding")\n  (:end . 129) (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "CD") (:stem . "-90") (:form . "-90") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-82") (:form . "-82") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 170)\n  (:start . 162) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s635.6) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005882@unknown@formal@none@1@S@Furthermore, we have demonstrated that both C/EBPbeta and GATA-1 can bind simultaneously to the C/EBP- and GATA-binding sites in the MBP promoter.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c/ebp-") (:form . "C/EBP-") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 119)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s635.7) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005883@unknown@formal@none@1@S@To determine the functionality of both the C/EBP- and GATA- binding sites, we analyzed whether C/EBPbeta and GATA-1 can stimulate the MBP promoter in the C/EBPbeta and GATA-1 negative Jurkat T-cell line.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "functionality") (:form . "functionality")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c/ebp-") (:form . "C/EBP-") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gata-") (:form . "GATA-") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 163)\n  (:start . 154) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 174)\n  (:start . 168) (:id . 70))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 183)\n  (:start . 175) (:id . 71))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 190)\n  (:start . 184) (:id . 72))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 197)\n  (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 202) (:start . 198)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x635.8.1) (:span 87 94)))\n (:hscopes ((:id . :x635.8.1) (:span 87 202)))\n (:identifiers (:sid . :s635.8) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005884@unknown@formal@none@1@S@Cotransfection with C/EBPbeta and GATA-1 expression vectors produced a 5-fold increase compared with cotransfection with the C/EBPbeta or GATA-1 expression vectors individually.@(((:tag . "NNP") (:stem . "Cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "5-fold") (:form . "5-fold") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 115) (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 134)\n  (:start . 125) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 144)\n  (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 61))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 163)\n  (:start . 156) (:id . 62))\n ((:tag . "RB") (:stem . "individually") (:form . "individually") (:end . 176)\n  (:start . 164) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s635.9) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005885@unknown@formal@none@1@S@In addition, GST pull-down experiments demonstrated a physical interaction between human GATA-1 and C/EBPbeta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GST") (:form . "GST") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pull-down") (:form . "pull-down") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C/EBPbeta") (:form . "C/EBPbeta") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s635.10) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005886@unknown@formal@none@1@S@Expression of FOG (riend ATA), which binds to GATA-1 and acts as a cofactor for GATA-binding proteins, decreased transactivation activity of GATA-1 for the MBP promoter in a dose-dependent manner.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "FOG") (:form . "FOG") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "riend") (:form . "riend") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ATA") (:form . "ATA") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 36) (:start . 31)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 42) (:start . 37)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 61) (:start . 57)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 75)\n  (:start . 67) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 92)\n  (:start . 80) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 101)\n  (:start . 93) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 112)\n  (:start . 103) (:id . 63))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 128) (:start . 113) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 147)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "MBP") (:form . "MBP") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 188) (:start . 174) (:id . 74))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 195)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s635.11) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005887@unknown@formal@none@1@S@Our results provide the first evidence that both GATA-1 and C/EBPbeta synergistically transactivate the promoter of an eosinophil-specific granule protein gene and that FOG may act as a negative cofactor for the eosinophil lineage, unlike its positively regulatory function for the erythroid and megakaryocyte lineages.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . 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"as") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 194)\n  (:start . 186) (:id . 70))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 203)\n  (:start . 195) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 207) (:start . 204)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 222)\n  (:start . 212) (:id . 74))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 230)\n  (:start . 223) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 231) (:start . 230)\n  (:id . 76))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 238)\n  (:start . 232) (:id . 77))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 242) (:start . 239)\n  (:id . 78))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 253)\n  (:start . 243) (:id . 79))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 264)\n  (:start . 254) (:id . 80))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 273)\n  (:start . 265) (:id . 81))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 277) (:start . 274)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 281) (:start . 278)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 291)\n  (:start . 282) (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 295) (:start . 292)\n  (:id . 85))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 309) (:start . 296) (:id . 86))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 318)\n  (:start . 310) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 319) (:start . 318)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x635.12.1) (:span 173 176)))\n (:hscopes ((:id . :x635.12.1) (:span 173 230)))\n (:identifiers (:sid . :s635.12) (:did . :|10438731|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005888@unknown@formal@none@1@S@Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7.@(((:tag . "JJ") (:stem . "thymocyte-thymic") (:form . "Thymocyte-thymic")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 44)\n  (:start . 33) (:id . 45))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 50) (:start . 45)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 64)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 76)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 102) (:start . 86) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 108)\n  (:start . 103) (:id . 53))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 120)\n  (:start . 109) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 130)\n  (:start . 124) (:id . 56))\n ((:tag . "JJ") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 137)\n  (:start . 131) (:id . 57))\n ((:tag . "JJ") (:stem . "CD8(-)") (:form . "CD8(-)") (:end . 144)\n  (:start . 138) (:id . 58))\n ((:tag . "CD") (:stem . "CD3(+)") (:form . "CD3(+)") (:end . 151)\n  (:start . 145) (:id . 59))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 162)\n  (:start . 152) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 163) (:start . 162)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 174)\n  (:start . 166) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 179) (:start . 175)\n  (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 183) (:start . 180)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 189)\n  (:start . 184) (:id . 66))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 198)\n  (:start . 190) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 205)\n  (:start . 199) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin-7") (:form . "interleukin-7")\n  (:end . 223) (:start . 210) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s636.1) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005890@unknown@formal@none@1@S@In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "t-tropic") (:form . "T-tropic") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "JJ") (:stem . "isolate") (:form . "isolate") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "VBN") (:stem . "HIV-1(B-LAIp)") (:form . "HIV-1(B-LAIp)")\n  (:end . 160) (:start . 147) (:id . 65))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 172)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 186)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 193)\n  (:start . 187) (:id . 70))\n ((:tag . "JJ") (:stem . "CD8(-)") (:form . "CD8(-)") (:end . 200)\n  (:start . 194) (:id . 71))\n ((:tag . "JJ") (:stem . "CD3(+)") (:form . "CD3(+)") (:end . 207)\n  (:start . 201) (:id . 72))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 218)\n  (:start . 208) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s636.3) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005891@unknown@formal@none@1@S@Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-7") (:form . "interleukin-7")\n  (:end . 45) (:start . 32) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 62)\n  (:start . 54) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 86)\n  (:start . 75) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 132)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 139)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 155) (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 183) (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 194)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s636.4) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005892@unknown@formal@none@1@S@TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "sustain") (:form . "sustaining") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 163)\n  (:start . 155) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s636.5) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005893@unknown@formal@none@1@S@The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "confirm") (:form . 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5005894@unknown@formal@none@1@S@Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 109)\n  (:start . 99) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 136)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "coculture") (:form . "cocultures") (:end . 154)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s636.7) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005895@unknown@formal@none@1@S@The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "subpopulation") (:form . "subpopulation")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . 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5005896@unknown@formal@none@1@S@Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 100)\n  (:start . 94) (:id . 61))\n ((:tag . "NNS") (:stem . "subpopulation") (:form . "subpopulations")\n  (:end . 115) (:start . 101) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 123) (:start . 119)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 129)\n  (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "load") (:form . "load") (:end . 134) (:start . 130)\n  (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 138) (:start . 135)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 141) (:start . 139)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 151)\n  (:start . 142) (:id . 70))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 163)\n  (:start . 152) (:id . 71))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 170)\n  (:start . 164) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 181)\n  (:start . 175) (:id . 74))\n ((:tag . "NN") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . "JJ") (:stem . "CD8(-)") (:form . "CD8(-)") (:end . 195)\n  (:start . 189) (:id . 76))\n ((:tag . "JJ") (:stem . "CD3(+)") (:form . "CD3(+)") (:end . 202)\n  (:start . 196) (:id . 77))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 209)\n  (:start . 203) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 223)\n  (:start . 213) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x636.9.1) (:span 135 138))\n  ((:id . :x636.9.2) (:span 21 28)))\n (:hscopes ((:id . :x636.9.1) (:span 117 223))\n  ((:id . :x636.9.2) (:span 21 223)))\n (:identifiers (:sid . :s636.9) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005897@unknown@formal@none@1@S@However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 113)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 173)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x636.10.1) (:span 72 77)))\n (:hscopes ((:id . :x636.10.1) (:span 72 188)))\n (:identifiers (:sid . :s636.10) (:did . :|10438843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005898@unknown@formal@none@1@S@IL-2-independent activation and proliferation in human T cells induced by CD28.@(((:tag . "JJ") (:stem . "il-2-independent") (:form . "IL-2-independent")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 45) (:start . 32) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s637.1) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005900@unknown@formal@none@1@S@In many circumstances it is difficult to distinguish the effects of CD28 from subsequent actions of cytokines, such as IL-2, on T cell proliferation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "distinguish") (:form . "distinguish") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 148) (:start . 135) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s637.3) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005901@unknown@formal@none@1@S@Here, we report a model of CD28 costimulation using PMA plus the natural ligand CD80 that resulted in very limited stimulation of IL-2, as evidenced by both cytokine production and IL-2 promoter stimulation.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 45) (:start . 32) (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 72)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "cd80") (:form . "CD80") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 148)\n  (:start . 139) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 165)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 176)\n  (:start . 166) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 194)\n  (:start . 186) (:id . 75))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 206)\n  (:start . 195) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s637.4) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005902@unknown@formal@none@1@S@Promoter assays revealed CD28-dependent effects on both NF-kappaB and AP-1, but not on NF-AT or the intact IL-2 promoter.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "cd28-dependent") (:form . "CD28-dependent")\n  (:end . 39) (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x637.5.1) (:span 80 83)))\n (:nscopes ((:id . :x637.5.1) (:span 80 120)))\n (:identifiers (:sid . :s637.5) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005903@unknown@formal@none@1@S@In addition, T cell proliferation was completely resistant to the actions of the immunosuppressant cyclosporin A (CsA).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 33) (:start . 20) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 98) (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s637.6) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005904@unknown@formal@none@1@S@Moreover T cell proliferation was unaffected by the addition of blocking Abs to both IL-2 and the IL-2 receptor, demonstrating that this form of costimulation by CD28 was independent of IL-2.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 126) (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 158) (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 182)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s637.7) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005905@unknown@formal@none@1@S@We also investigated the effects of stimulating T cell blasts with CD80 alone and found that there was a limited requirement for IL-2 in this system.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd80") (:form . "CD80") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 124)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 148)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s637.8) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005906@unknown@formal@none@1@S@We conclude that CD28 costimulation can cause substantial T cell proliferation in the absence of IL-2, which is driven by a soluble factor independent of NF-AT transactivation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 78) (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 150)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 175) (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x637.9.1) (:span 86 93)))\n (:nscopes ((:id . :x637.9.1) (:span 86 101)))\n (:identifiers (:sid . :s637.9) (:did . :|10438913|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005907@unknown@formal@none@1@S@Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "tnfalpha-mediated") (:form . "TNFalpha-mediated")\n  (:end . 32) (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "myricetin") (:form . "myricetin") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 92)\n  (:start . 85) (:id . 52))\n ((:tag . "VBG") (:stem . "downregulate") (:form . "downregulating")\n  (:end . 107) (:start . 93) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 120)\n  (:start . 112) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 127) (:start . 124)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ecv304") (:form . "ECV304") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s638.1) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005908@unknown@formal@none@1@S@Flavonoids are a group of naturally-occurring phenolic compounds in the plant kingdom, and many flavonoids are found with vascular protective properties.@(((:tag . "NNS") (:stem . "flavonoid") (:form . "Flavonoids") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "naturally-occurring")\n  (:form . "naturally-occurring") (:end . 45) (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "phenolic") (:form . "phenolic") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "plant") (:form . "plant") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kingdom") (:form . "kingdom") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s638.2) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005910@unknown@formal@none@1@S@In view of the nuclear factor-kappaB (NFkappaB) may play a central role in the initiation of atherosclerosis, prevention of the activation of NFkappaB represents an important role in protecting vascular injury.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 89)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 108) (:start . 93) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 138)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 161)\n  (:start . 151) (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 174)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 179) (:start . 175)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "protect") (:form . "protecting") (:end . 193)\n  (:start . 183) (:id . 73))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 202)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 209)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x638.4.1) (:span 48 51)))\n (:hscopes ((:id . :x638.4.1) (:span 48 108)))\n (:identifiers (:sid . :s638.4) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005911@unknown@formal@none@1@S@In this study, the effects of flavonoids on NFkappaB/inhibitor-kappaB (IkappaB) system in ECV304 cells activated with tumor necrosis factor-alpha (TNFalpha) were examined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFkappaB/inhibitor-kappaB")\n  (:form . "NFkappaB/inhibitor-kappaB") (:end . 69) (:start . 44) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ecv304") (:form . "ECV304") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 145)\n  (:start . 133) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s638.5) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005912@unknown@formal@none@1@S@We investigated the inhibitory action of six flavonoids on IkappaB kinase (IKK) activity, an enzyme recently found to phosphorylate critical serine residues of IkappaB for degradation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "VB") (:stem . "phosphorylate") (:form . "phosphorylate")\n  (:end . 131) (:start . 118) (:id . 63))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 183)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s638.6) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005913@unknown@formal@none@1@S@Of six flavonoids tested, myricetin was found to strongly inhibit IKK kinase activity, and prevent the degradation of IkappaBalpha and IkappaBbeta in activated endothelial cells.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 24) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "myricetin") (:form . "myricetin") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "prevent") (:form . "prevent") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 130) (:start . 118) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 146)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 159)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 171)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s638.7) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005914@unknown@formal@none@1@S@Furthermore, myricetin was also found to inhibit NFkappaB activity correlated with suppression of monocyte adhesion to ECV304 cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "myricetin") (:form . "myricetin") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ecv304") (:form . "ECV304") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s638.8) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005915@unknown@formal@none@1@S@Therefore we conclude that flavonoids may be of therapeutic value for vascular disease through down regulation of NFkappaB/IkappaB system.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "flavonoid") (:form . "flavonoids") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "down") (:form . "down") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFkappaB/IkappaB") (:form . "NFkappaB/IkappaB")\n  (:end . 130) (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x638.9.1) (:span 38 41)))\n (:hscopes ((:id . :x638.9.1) (:span 38 137)))\n (:identifiers (:sid . :s638.9) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005916@unknown@formal@none@1@S@Copyright 1999 Wiley-Liss, Inc.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1999") (:form . "1999") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Wiley-Liss") (:form . "Wiley-Liss") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Inc") (:form . "Inc") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 31) (:start . 30)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s638.10) (:did . :|10440930|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005917@unknown@formal@none@1@S@Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "all-trans-retinoic") (:form . "all-trans-retinoic")\n  (:end . 66) (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 79)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 105) (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "m2-type") (:form . "M2-type") (:end . 116)\n  (:start . 109) (:id . 55))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 125)\n  (:start . 117) (:id . 56))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 131)\n  (:start . 126) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s639.1) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005918@unknown@formal@none@1@S@Different types of acute myeloid leukemia blast cells were induced to differentiate in vitro with all-trans-retinoic acid (ATRA) and vitamin D3 (VD).@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "all-trans-retinoic") (:form . "all-trans-retinoic")\n  (:end . 116) (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s639.2) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005920@unknown@formal@none@1@S@M2 leukemic blast cells behave differently because they undergo monocytic differentiation with both the differentiation inducers.@(((:tag . "NN") (:stem . "m2") (:form . "M2") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "behave") (:form . "behave") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 89) (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 119) (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 128)\n  (:start . 120) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s639.4) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005921@unknown@formal@none@1@S@To gain some insight into the maturation of M2-type leukemic cells, we studied the molecular mechanisms underlying monocytic differentiation induced by ATRA and VD in spontaneous M2 blast cells as well as in Kasumi-1 cells (an acute myeloid leukemia M2-type cell line).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "m2-type") (:form . "M2-type") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 140) (:start . 125) (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 156) (:start . 152)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "spontaneous") (:form . "spontaneous") (:end . 178)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "m2") (:form . "M2") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 187)\n  (:start . 182) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 196) (:start . 194)\n  (:id . 72))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 201) (:start . 197)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kasumi-1") (:form . "Kasumi-1") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 222)\n  (:start . 217) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 224) (:start . 223)\n  (:id . 78))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 226) (:start . 224)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 232)\n  (:start . 227) (:id . 80))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 240)\n  (:start . 233) (:id . 81))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 249)\n  (:start . 241) (:id . 82))\n ((:tag . "NN") (:stem . "m2-type") (:form . "M2-type") (:end . 257)\n  (:start . 250) (:id . 83))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 262) (:start . 258)\n  (:id . 84))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 267) (:start . 263)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 268) (:start . 267)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s639.5) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005922@unknown@formal@none@1@S@Our results indicate that ATRA as well as VD efficiently increases the nuclear abundance of VD receptor (VDR) and promotes monocytic differentiation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "VD") (:form . "VD") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 148) (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x639.6.1) (:span 12 25)))\n (:hscopes ((:id . :x639.6.1) (:span 12 148)))\n (:identifiers (:sid . :s639.6) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005923@unknown@formal@none@1@S@VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene.@(((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 19)\n  (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "atra-treated") (:form . "ATRA-treated") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "kasumi-1") (:form . "Kasumi-1") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "VBZ") (:stem . "heterodimerize") (:form . "heterodimerizes")\n  (:end . 96) (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dr3-type") (:form . "DR3-type") (:end . 142)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "JJ") (:stem . "d-responsive") (:form . "D-responsive") (:end . 163)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 171)\n  (:start . 164) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 186)\n  (:start . 177) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 204) (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 72))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 217)\n  (:start . 210) (:id . 73))\n ((:tag . "JJ") (:stem . "d-responsive") (:form . "D-responsive") (:end . 230)\n  (:start . 218) (:id . 74))\n ((:tag . "JJ") (:stem . "element-regulated") (:form . "element-regulated")\n  (:end . 248) (:start . 231) (:id . 75))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 257)\n  (:start . 249) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 262) (:start . 258)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s639.7) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005924@unknown@formal@none@1@S@Consistent with these findings, VD-responsive genes are induced by ATRA treatment of Kasumi-1 cells, suggesting that the genetic program underlying monocytic differentiation is activated.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "vd-responsive") (:form . "VD-responsive")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kasumi-1") (:form . "Kasumi-1") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 157)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 173) (:start . 158) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 186)\n  (:start . 177) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x639.8.1) (:span 101 111)))\n (:hscopes ((:id . :x639.8.1) (:span 101 186)))\n (:identifiers (:sid . :s639.8) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005925@unknown@formal@none@1@S@The molecular mechanism by which ATRA increases the nuclear abundance of a functional VDR is still unknown, but our data clearly indicate that the M2 leukemic cell context is only permissive of monocytic differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "vdr") (:form . "VDR") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 120)\n  (:start . 116) (:id . 62))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "m2") (:form . "M2") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 158)\n  (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 190)\n  (:start . 180) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 203)\n  (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 219) (:start . 204) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x639.9.1) (:span 129 142))\n  ((:id . :x639.9.2) (:span 99 106)))\n (:hscopes ((:id . :x639.9.1) (:span 129 219))\n  ((:id . :x639.9.2) (:span 0 106)))\n (:identifiers (:sid . :s639.9) (:did . :|10446999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005926@unknown@formal@none@1@S@Signal transduction pathways triggered by the FcepsilonRIIb receptor (CD23) in human monocytes lead to nuclear factor-kappaB activation.@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "FcepsilonRIIb") (:form . "FcepsilonRIIb")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 124) (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s640.1) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005927@unknown@formal@none@1@S@BACKGROUND: Alveolar macrophages play a key role in the initiation of the inflammatory reaction of allergic asthma.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "Alveolar") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s640.2) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005928@unknown@formal@none@1@S@Alveolar macrophages and peripheral blood monocytes are activated when IgE/allergen immune complexes bind to the CD23 receptor, which leads to the production of inflammatory cytokines.@(((:tag . "JJ") (:stem . "alveolar") (:form . "Alveolar") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IgE/allergen") (:form . "IgE/allergen") (:end . 83)\n  (:start . 71) (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 90)\n  (:start . 84) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 100)\n  (:start . 91) (:id . 53))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 173)\n  (:start . 161) (:id . 66))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 183)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s640.3) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005930@unknown@formal@none@1@S@We have focused on the study of the signal transduction pathways triggered by CD23 in human monocytes and the promonocytic cell line U937.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 55)\n  (:start . 43) (:id . 51))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 122)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s640.5) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005931@unknown@formal@none@1@S@METHODS: CD23 was cross-linked in human monocytes and U937 cells with IgE immune complexes.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cross-linked") (:form . "cross-linked") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s640.6) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005932@unknown@formal@none@1@S@Surface expression of CD23 was determined by FACS analysis.@(((:tag . "NN") (:stem . "surface") (:form . "Surface") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FACS") (:form . "FACS") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s640.7) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005933@unknown@formal@none@1@S@Transcription factor activation and gene transcription were studied by gel-shift assays and Northern blot analysis, respectively.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "northern") (:form . "Northern") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 114)\n  (:start . 106) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 128)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s640.8) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005934@unknown@formal@none@1@S@IkappaBalpha phosphorylation and degradation was analyzed by Western blot.@(((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 28) (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 44))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 44)\n  (:start . 33) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 57)\n  (:start . 49) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 68)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s640.9) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005935@unknown@formal@none@1@S@RESULTS: Nuclear factor (NF)-kappaB is the main transcription factor involved in the gene activation that follows CD23 cross-linking in monocytes.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s640.10) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005936@unknown@formal@none@1@S@CD23-induced NF-kappaB is a heterodimer composed of p65/p50 subunits.@(((:tag . "JJ") (:stem . "cd23-induced") (:form . "CD23-induced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p65/p50") (:form . "p65/p50") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s640.11) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005937@unknown@formal@none@1@S@NF-kappaB nuclear translocation is secondary to the phosphorylation and subsequent degradation of the NF-kappaB inhibitory molecule IkappaBalpha.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 94)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 111)\n  (:start . 102) (:id . 55))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 122)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 131)\n  (:start . 123) (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 144) (:start . 132) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s640.12) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005938@unknown@formal@none@1@S@Tyrosine kinase-dependent, and not protein kinase C-dependent, pathways mediate CD23-triggered NF-kappaB activation but do not participate in the direct phosphorylation of IkappaBalpha.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "kinase-dependent") (:form . "kinase-dependent")\n  (:end . 25) (:start . 9) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "c-dependent") (:form . "C-dependent") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "JJ") (:stem . "cd23-triggered") (:form . "CD23-triggered")\n  (:end . 94) (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 152)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 168) (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 184) (:start . 172) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x640.13.1) (:span 123 126))\n  ((:id . :x640.13.2) (:span 31 34)))\n (:nscopes ((:id . :x640.13.1) (:span 123 184))\n  ((:id . :x640.13.2) (:span 31 61)))\n (:identifiers (:sid . :s640.13) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005940@unknown@formal@none@1@S@CONCLUSIONS: NF-kappaB is the main transcription factor involved in the signal transduction pathway of CD23 in monocytes.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 91)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s640.15) (:did . :|10452760|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005941@unknown@formal@none@1@S@Dopamine stimulates expression of the human immunodeficiency virus type 1 via NF-kappaB in cells of the immune system.@(((:tag . "NNP") (:stem . "Dopamine") (:form . "Dopamine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 60) (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 66) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s641.1) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005942@unknown@formal@none@1@S@Recent studies have reported that lymphocytes produce, transport and bind dopamine present in plasma.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "transport") (:form . "transport") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s641.2) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005943@unknown@formal@none@1@S@However, the action of dopamine on HIV-1 gene expression in cells of the immune system has not yet been examined.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 112)\n  (:start . 104) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x641.3.1) (:span 91 94)))\n (:nscopes ((:id . :x641.3.1) (:span 9 112)))\n (:identifiers (:sid . :s641.3) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005944@unknown@formal@none@1@S@Here, we have investigated the regulation of HIV-1 expression by dopamine in Jurkat T cells and in primary blood mononuclear cells (PBMC).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 26)\n  (:start . 14) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 124)\n  (:start . 113) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s641.4) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005945@unknown@formal@none@1@S@HIV-1 replication was increased by dopamine, which correlated with the increased levels of HIV-1 transactivation.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 112) (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s641.5) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005946@unknown@formal@none@1@S@Our transient expression data revealed that dopamine stimulated transcription through the NF-kappaB element present in the long terminal repeat.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 85)\n  (:start . 78) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 99)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 107)\n  (:start . 100) (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 115)\n  (:start . 108) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 143)\n  (:start . 137) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s641.6) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005947@unknown@formal@none@1@S@The importance of NF-kappaB sites was confirmed by using vectors containing wild-type or mutant kappaB sites in a heterologous promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 102)\n  (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 126)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s641.7) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005948@unknown@formal@none@1@S@Consistent with the role of NF-kappaB in mediating dopamine responsiveness, the proteasome inhibitor MG132 abolished dopamine-induced transcriptional activation.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 74) (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "mg132") (:form . "MG132") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "JJ") (:stem . "dopamine-induced") (:form . "dopamine-induced")\n  (:end . 133) (:start . 117) (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 149) (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 160)\n  (:start . 150) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s641.8) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005950@unknown@formal@none@1@S@The combination of dopamine and TNF-alpha led to a stimulation of HIV-1 transcription and replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s641.10) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005951@unknown@formal@none@1@S@However, in contrast with TNF-alpha, dopamine treatment did not affect NF-kappaB DNA binding activity nor the concentrations of p50, p65 and IkappaB-alpha proteins, which suggests a distinct NF-kappaB activation mechanism.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 124) (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 154) (:start . 141) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 163)\n  (:start . 155) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 170)\n  (:start . 165) (:id . 69))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 211)\n  (:start . 201) (:id . 74))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 221)\n  (:start . 212) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x641.11.1) (:span 171 179)))\n (:ncues ((:id . :x641.11.2) (:span 60 63 102 105)))\n (:hscopes ((:id . :x641.11.1) (:span 171 221)))\n (:nscopes ((:id . :x641.11.2) (:span 60 163)))\n (:identifiers (:sid . :s641.11) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005952@unknown@formal@none@1@S@These results reveal a new link between the dopamine system, cytokine signaling pathway and regulation of gene expression via the involvement of NF-kappaB in T cells and PBMC.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dopamine") (:form . "dopamine") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 141)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s641.12) (:did . :|10454636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005953@unknown@formal@none@1@S@Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 42) (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 81)\n  (:start . 72) (:id . 51))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 96)\n  (:start . 90) (:id . 53))\n ((:tag . "JJ") (:stem . "signalsome") (:form . "signalsome") (:end . 107)\n  (:start . 97) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ikappab") (:form . "IkappaB") (:end . 130)\n  (:start . 123) (:id . 57))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 142)\n  (:start . 131) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s642.1) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005954@unknown@formal@none@1@S@The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 45) (:start . 27) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s642.2) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005955@unknown@formal@none@1@S@This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . 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5005956@unknown@formal@none@1@S@Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.@(((:tag . "NNP") (:stem . "Kinase") (:form . "Kinase") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 20) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "elicit") (:form . "elicited") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "short-lived") (:form . "short-lived") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "3-fold") (:form . "3-fold") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IKK-alpha") (:form . "IKK-alpha") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IKK-beta") (:form . "IKK-beta") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "peak") (:form . "peaking") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 161) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s642.4) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005957@unknown@formal@none@1@S@In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "IKK-beta") (:form . "IKK-beta") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "slowly") (:form . "slowly") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "peak") (:form . "peaking") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s642.5) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005958@unknown@formal@none@1@S@A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IKK-alpha") (:form . "IKK-alpha") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s642.6) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005960@unknown@formal@none@1@S@Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IKK-alpha/beta") (:form . "IKK-alpha/beta")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 101) (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "-epsilon") (:form . "-epsilon") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s642.8) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005961@unknown@formal@none@1@S@Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.@(((:tag . "NN") (:stem . "exposure") (:form . "Exposure") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 42)\n  (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 68) (:start . 55) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IkappaB-epsilon") (:form . "IkappaB-epsilon")\n  (:end . 88) (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "disappearance") (:form . "disappearance")\n  (:end . 102) (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "reassembly") (:form . "reassembly") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signalsome") (:form . "signalsome") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "NNP") (:stem . "IKK-alpha") (:form . "IKK-alpha") (:end . 161)\n  (:start . 152) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IKK-beta") (:form . "IKK-beta") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 189)\n  (:start . 181) (:id . 70))\n ((:tag . "JJ") (:stem . "complex-associated") (:form . "complex-associated")\n  (:end . 208) (:start . 190) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s642.9) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005962@unknown@formal@none@1@S@NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.@(((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "phosphorylate") (:form . "phosphorylate")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 38) (:start . 25) (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 133)\n  (:start . 124) (:id . 61))\n ((:tag . "JJ") (:stem . "stimulus-induced") (:form . "stimulus-induced")\n  (:end . 150) (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 167) (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 181) (:start . 168) (:id . 64))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 186) (:start . 182)\n  (:id . 65))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 198)\n  (:start . 187) (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 203) (:start . 199)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 211)\n  (:start . 204) (:id . 68))\n ((:tag . "NNP") (:stem . "IKK-alpha") (:form . "IKK-alpha") (:end . 221)\n  (:start . 212) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 224) (:start . 222)\n  (:id . 70))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 230)\n  (:start . 225) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x642.10.1) (:span 56 63)))\n (:ncues ((:id . :x642.10.2) (:span 4 10)))\n (:hscopes ((:id . :x642.10.1) (:span 53 102)))\n (:nscopes ((:id . :x642.10.2) (:span 4 47)))\n (:identifiers (:sid . :s642.10) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005963@unknown@formal@none@1@S@Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "complex-associated") (:form . "complex-associated")\n  (:end . 40) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 58)\n  (:start . 49) (:id . 47))\n ((:tag . "JJ") (:stem . "stimulus-mediated") (:form . "stimulus-mediated")\n  (:end . 76) (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 50))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 99)\n  (:start . 92) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 109)\n  (:start . 100) (:id . 52))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 119)\n  (:start . 110) (:id . 53))\n ((:tag . "NN") (:stem . "modulator") (:form . "modulator") (:end . 129)\n  (:start . 120) (:id . 54))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 138)\n  (:start . 130) (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 141) (:start . 139)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s642.11) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005964@unknown@formal@none@1@S@The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS-") (:form . "LPS-") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tnf-induced") (:form . "TNF-induced") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "VB") (:stem . "treat") (:form . "treat") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "sepsis-associated") (:form . "sepsis-associated")\n  (:end . 127) (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x642.12.1) (:span 52 55)))\n (:hscopes ((:id . :x642.12.1) (:span 52 135)))\n (:identifiers (:sid . :s642.12) (:did . :|10455128|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005965@unknown@formal@none@1@S@AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.@(((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "cbfalpha2") (:form . "CBFalpha2") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 48) (:start . 35) (:id . 49))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "BSAP/PAX5") (:form . "BSAP/PAX5") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "BLK") (:form . "BLK") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s643.1) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005966@unknown@formal@none@1@S@AML1 plays a critical role during hematopoiesis and chromosomal translocations involving AML1 are commonly associated with different forms of leukemia, including pre-B acute lymphoblastic leukemia.@(((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 78) (:start . 64) (:id . 51))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 93) (:start . 89)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 132)\n  (:start . 123) (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 138)\n  (:start . 133) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 150)\n  (:start . 142) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 161)\n  (:start . 152) (:id . 63))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 167)\n  (:start . 162) (:id . 64))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 173)\n  (:start . 168) (:id . 65))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 187) (:start . 174) (:id . 66))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 196)\n  (:start . 188) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s643.2) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005967@unknown@formal@none@1@S@To understand the function of AML1 during B cell differentiation, we analyzed regulatory regions of B cell-specific genes for potential AML1-binding sites and have identified a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 64) (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "aml1-binding") (:form . "AML1-binding") (:end . 148)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 185)\n  (:start . 177) (:id . 69))\n ((:tag . "JJ") (:stem . "aml1-binding") (:form . "AML1-binding") (:end . 198)\n  (:start . 186) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 203) (:start . 199)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 219)\n  (:start . 211) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 228) (:start . 227)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 242) (:start . 229) (:id . 78))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 251)\n  (:start . 243) (:id . 79))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 258)\n  (:start . 252) (:id . 80))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 263) (:start . 259)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 264) (:start . 263)\n  (:id . 82))\n ((:tag . "NN") (:stem . "blk") (:form . "blk") (:end . 268) (:start . 265)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x643.3.1) (:span 177 185))\n  ((:id . :x643.3.2) (:span 126 135)))\n (:hscopes ((:id . :x643.3.1) (:span 177 203))\n  ((:id . :x643.3.2) (:span 126 154)))\n (:identifiers (:sid . :s643.3) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005968@unknown@formal@none@1@S@Gel mobility shift assays and transient transfection assays demonstrate that AML1 binds specifically to this site in the blk promoter and this binding site is important for blk promoter activity.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 100)\n  (:start . 88) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "blk") (:form . "blk") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "blk") (:form . "blk") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 185)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 194)\n  (:start . 186) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s643.4) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005970@unknown@formal@none@1@S@BSAP has been shown previously to be important for B cell-specific regulation of the blk gene.@(((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "blk") (:form . "blk") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s643.6) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005971@unknown@formal@none@1@S@Physical interaction of AML1 with BSAP correlates with functional cooperativity in transfection studies where AML1 and BSAP synergistically activate blk promoter transcription by more than 50-fold.@(((:tag . "JJ") (:stem . "physical") (:form . "Physical") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "cooperativity") (:form . "cooperativity")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 103)\n  (:start . 96) (:id . 54))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 109)\n  (:start . 104) (:id . 55))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 139) (:start . 124) (:id . 59))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 148)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "blk") (:form . "blk") (:end . 152) (:start . 149)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 161)\n  (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 183) (:start . 179)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 188) (:start . 184)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "50-fold") (:form . "50-fold") (:end . 196)\n  (:start . 189) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s643.7) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005972@unknown@formal@none@1@S@These results demonstrate physical and functional interactions between AML1 and BSAP and suggest that AML1 is an important factor for regulating a critical B cell-specific gene, blk.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 62)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 70)\n  (:start . 63) (:id . 49))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 171) (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "blk") (:form . "blk") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x643.8.1) (:span 89 96)))\n (:hscopes ((:id . :x643.8.1) (:span 89 181)))\n (:identifiers (:sid . :s643.8) (:did . :|10455134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005973@unknown@formal@none@1@S@c-Maf induces monocytic differentiation and apoptosis in bipotent myeloid progenitors.@(((:tag . "NN") (:stem . "c-maf") (:form . "c-Maf") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "bipotent") (:form . "bipotent") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 85)\n  (:start . 74) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s644.1) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005974@unknown@formal@none@1@S@The transcriptional mechanisms that drive colony-forming unit granulocyte-macrophage (CFU-GM) myeloid progenitors to differentiate into cells of either the granulocytic or monocytic lineage are not fully understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "drive") (:form . "drive") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "colony-forming") (:form . "colony-forming")\n  (:end . 56) (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "NN") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 84) (:start . 62) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CFU-GM") (:form . "CFU-GM") (:end . 92)\n  (:start . 86) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 101)\n  (:start . 94) (:id . 53))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 113)\n  (:start . 102) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 55))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 130) (:start . 117) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 135) (:start . 131)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 59))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 151)\n  (:start . 145) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 168)\n  (:start . 156) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 171) (:start . 169)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 181)\n  (:start . 172) (:id . 64))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 189)\n  (:start . 182) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 193) (:start . 190)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 197) (:start . 194)\n  (:id . 67))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 203)\n  (:start . 198) (:id . 68))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 214)\n  (:start . 204) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s644.2) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005975@unknown@formal@none@1@S@We have shown that the c-Maf and c-Myb transcription factors physically interact in myeloid cells to form inhibitory complexes that hinder transactivation of c-Myb target genes through direct binding to Myb consensus sites.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-maf") (:form . "c-Maf") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "hinder") (:form . "hinder") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 154) (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 191)\n  (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 199)\n  (:start . 192) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Myb") (:form . "Myb") (:end . 206) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 216)\n  (:start . 207) (:id . 73))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 222)\n  (:start . 217) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s644.3) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005976@unknown@formal@none@1@S@These complexes arise in a developmentally regulated pattern, peaking at the promyelocyte stage, or in cell model systems, appearing soon after the induction of monocytic differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "arise") (:form . "arise") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 42) (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "peak") (:form . "peaking") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "appear") (:form . "appearing") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "RB") (:stem . "soon") (:form . "soon") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 170)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 186) (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s644.4) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005977@unknown@formal@none@1@S@We wished to determine if this developmentally related interaction is a consequence of myeloid differentiation or an intrinsic differentiating stimulus.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "wish") (:form . "wished") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 46) (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 110) (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 142) (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 151)\n  (:start . 143) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x644.5.1) (:span 111 113))\n  ((:id . :x644.5.2) (:span 23 25)))\n (:hscopes ((:id . :x644.5.1) (:span 72 151))\n  ((:id . :x644.5.2) (:span 23 151)))\n (:identifiers (:sid . :s644.5) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005978@unknown@formal@none@1@S@Because the elevated Myb:Maf status seen in differentiating cells can be recapitulated by overexpression of c-Maf in myeloid cell lines, we inducibly expressed the c-Maf cDNA in 2 bipotent human myeloid progenitor cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "Myb:Maf") (:form . "Myb:Maf") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 59) (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "recapitulate") (:form . "recapitulated")\n  (:end . 86) (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 104) (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-maf") (:form . "c-Maf") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "RB") (:stem . "inducibly") (:form . "inducibly") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-maf") (:form . "c-Maf") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "bipotent") (:form . "bipotent") (:end . 188)\n  (:start . 180) (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 194)\n  (:start . 189) (:id . 72))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 213)\n  (:start . 203) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 219)\n  (:start . 214) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s644.6) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005980@unknown@formal@none@1@S@Analysis of targets that could mediate these phenotypic changes indicated that c-Maf likely plays a key role in myeloid cell development through dual mechanisms; inhibition of a select set of c-Myb regulated targets, such as Bcl-2 and CD13/APN, coupled with the activation of as yet undefined differentiation-promoting genes.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-maf") (:form . "c-Maf") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 136)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 160)\n  (:start . 150) (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "select") (:form . "select") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 207)\n  (:start . 198) (:id . 74))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 215)\n  (:start . 208) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 221) (:start . 217)\n  (:id . 77))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 224) (:start . 222)\n  (:id . 78))\n ((:tag . 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"yet") (:end . 282) (:start . 279)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "undefined") (:form . "undefined") (:end . 292)\n  (:start . 283) (:id . 90))\n ((:tag . "JJ") (:stem . "differentiation-promoting")\n  (:form . "differentiation-promoting") (:end . 318) (:start . 293)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 324)\n  (:start . 319) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 325) (:start . 324)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x644.8.1) (:span 85 91)) ((:id . :x644.8.2) (:span 64 78)))\n (:hscopes ((:id . :x644.8.1) (:span 79 324))\n  ((:id . :x644.8.2) (:span 64 324)))\n (:identifiers (:sid . :s644.8) (:did . :|10477683|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005981@unknown@formal@none@1@S@Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "factor-kappab-dependent")\n  (:form . "factor-kappaB-dependent") (:end . 31) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 41)\n  (:start . 32) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 58) (:start . 45) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 92)\n  (:start . 84) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 105)\n  (:start . 100) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 106) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 115)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 134)\n  (:start . 123) (:id . 58))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 144)\n  (:start . 135) (:id . 59))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 155)\n  (:start . 145) (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 163)\n  (:start . 156) (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 172)\n  (:start . 164) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 177) (:start . 173)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 185)\n  (:start . 178) (:id . 64))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 199) (:start . 186) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s645.1) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005982@unknown@formal@none@1@S@Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pluripotent") (:form . "pluripotent") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 81)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 111) (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s645.2) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005983@unknown@formal@none@1@S@This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CXC") (:form . "CXC") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s645.3) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005984@unknown@formal@none@1@S@In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tnfalpha-inducible") (:form . "TNFalpha-inducible")\n  (:end . 60) (:start . 42) (:id . 51))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "\\"monocyte-like") (:form . "\\"monocyte-like")\n  (:end . 127) (:start . 113) (:id . 62))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "histiocytic") (:form . "histiocytic") (:end . 145)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s645.4) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005985@unknown@formal@none@1@S@TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.@(((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "50-fold") (:form . "50-fold") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 127)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s645.5) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005986@unknown@formal@none@1@S@In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 165)\n  (:start . 157) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s645.6) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005987@unknown@formal@none@1@S@TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel A, whose binding in the nucleus occurs before changes in intracellular ROS.@(((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 77) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 105)\n  (:start . 98) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 181) (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "ros") (:form . "ROS") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s645.7) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005988@unknown@formal@none@1@S@Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "posttreatment") (:form . "posttreatment")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "dimethyl") (:form . "dimethyl") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "sulfoxide") (:form . "sulfoxide") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DMSO") (:form . "DMSO") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "NN") (:stem . "vol/vol") (:form . "vol/vol") (:end . 129)\n  (:start . 122) (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 138)\n  (:start . 132) (:id . 69))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 141) (:start . 139)\n  (:id . 70))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 142) (:start . 141)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 165) (:start . 146) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s645.8) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005990@unknown@formal@none@1@S@Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 93)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 111) (:start . 95) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s645.10) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005991@unknown@formal@none@1@S@These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "ros-dependent") (:form . "ROS-dependent")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 131) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 142)\n  (:start . 132) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 149) (:start . 147)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "separable") (:form . "separable") (:end . 159)\n  (:start . 150) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 164) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 178)\n  (:start . 170) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 182) (:start . 179)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 186) (:start . 183)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 194)\n  (:start . 187) (:id . 68))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 208) (:start . 195) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x645.11.1) (:span 11 24)))\n (:hscopes ((:id . :x645.11.1) (:span 11 208)))\n (:identifiers (:sid . :s645.11) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005992@unknown@formal@none@1@S@Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "yield") (:form . "yield") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 76)\n  (:start . 64) (:id . 52))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 109)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s645.12) (:did . :|10477716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005993@unknown@formal@none@1@S@Neutrophil maturation and the role of retinoic acid.@(((:tag . "NNP") (:stem . "Neutrophil") (:form . "Neutrophil") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s646.1) (:did . :|10480426|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5005994@unknown@formal@none@1@S@Neutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function.@(((:tag . "NNP") (:stem . "Neutrophil") (:form . "Neutrophil") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 28)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "morphological") (:form . "morphological")\n  (:end . 58) (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "acquisition") (:form . "acquisition") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 133)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 149)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 158)\n  (:start . 150) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s646.2) (:did . :|10480426|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005995@unknown@formal@none@1@S@A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 57)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 68)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s646.3) (:did . :|10480426|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005996@unknown@formal@none@1@S@Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s646.4) (:did . :|10480426|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005997@unknown@formal@none@1@S@A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "source") (:form . "sources") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x646.5.1) (:span 63 72)))\n (:hscopes ((:id . :x646.5.1) (:span 0 98)))\n (:identifiers (:sid . :s646.5) (:did . :|10480426|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5005998@unknown@formal@none@1@S@Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil maturation.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 174)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s646.6) (:did . :|10480426|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006000@unknown@formal@none@1@S@Human T-cell leukemia virus type 1 (HTLV-1) Tax is thought to play a pivotal role in immortalization of T cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 76)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 81) (:start . 77)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 100) (:start . 85) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x647.2.1) (:span 51 58)))\n (:hscopes ((:id . :x647.2.1) (:span 0 111)))\n (:identifiers (:sid . :s647.2) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006001@unknown@formal@none@1@S@We have recently shown that the expression of Tax protected the mouse T-cell line CTLL-2 against apoptosis induced by interleukin-2 (IL-2) deprivation and converted its growth from being IL-2 dependent to being IL-2 independent.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "protect") (:form . "protected") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 131) (:start . 118) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 150)\n  (:start . 139) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "convert") (:form . "converted") (:end . 164)\n  (:start . 155) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 186) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 191) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 201)\n  (:start . 192) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 210) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 215) (:start . 211)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 227)\n  (:start . 216) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s647.3) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006002@unknown@formal@none@1@S@In this study, we demonstrate that constitutive expression of bcl-xl but not bcl-2, bcl-xs, bak, bad, or bax was associated with apoptosis resistance after IL-2 deprivation in CTLL-2 cells that expressed Tax.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 47)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bcl-xl") (:form . "bcl-xl") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "bcl-x") (:form . "bcl-xs") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bak") (:form . "bak") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "bad") (:form . "bad") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bax") (:form . "bax") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 123)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 67))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 138)\n  (:start . 129) (:id . 68))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 149)\n  (:start . 139) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 155)\n  (:start . 150) (:id . 70))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 160) (:start . 156)\n  (:id . 71))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 172)\n  (:start . 161) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 182)\n  (:start . 176) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 188)\n  (:start . 183) (:id . 75))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 193) (:start . 189)\n  (:id . 76))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 203)\n  (:start . 194) (:id . 77))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x647.4.1) (:span 73 76)))\n (:nscopes ((:id . :x647.4.1) (:span 73 108)))\n (:identifiers (:sid . :s647.4) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006003@unknown@formal@none@1@S@Transient-transfection assays showed that bcl-x promoter was transactivated by wild-type Tax.@(((:tag . "NNP") (:stem . "Transient-transfection")\n  (:form . "Transient-transfection") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 29)\n  (:start . 23) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 36) (:start . 30)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-x") (:form . "bcl-x") (:end . 47) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 75) (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 88)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s647.5) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006004@unknown@formal@none@1@S@Similar effects were observed in mutant Tax retaining transactivating ability through NF-kappaB.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "retain") (:form . "retaining") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 69) (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 95)\n  (:start . 86) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s647.6) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006005@unknown@formal@none@1@S@Deletion or substitution of a putative NF-kappaB binding site identified in the bcl-x promoter significantly decreased Tax-induced transactivation.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bcl-x") (:form . "bcl-x") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 118)\n  (:start . 109) (:id . 57))\n ((:tag . "JJ") (:stem . "tax-induced") (:form . "Tax-induced") (:end . 130)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 146) (:start . 131) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x647.7.1) (:span 30 38)))\n (:hscopes ((:id . :x647.7.1) (:span 30 94)))\n (:identifiers (:sid . :s647.7) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006006@unknown@formal@none@1@S@This NF-kappaB-like element was able to form a complex with NF-kappaB family proteins in vitro.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nf-kappab-like") (:form . "NF-kappaB-like")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s647.8) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006007@unknown@formal@none@1@S@Furthermore, Tax-induced transactivation of the bcl-x promoter was also diminished by the mutant IkappaBalpha, which specifically inhibits NF-kappaB activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "tax-induced") (:form . "Tax-induced") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 40) (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bcl-x") (:form . "bcl-x") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 109) (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 129)\n  (:start . 117) (:id . 59))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 148)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 157)\n  (:start . 149) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s647.9) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006008@unknown@formal@none@1@S@Our findings suggest that constitutive expression of Bcl-x(L) induced by Tax through the NF-kappaB pathway contributes to the inhibition of apoptosis in CTLL-2 cells after IL-2 deprivation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "Bcl-x(L)") (:form . "Bcl-x(L)") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 118)\n  (:start . 107) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 136)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 159)\n  (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 171)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 188)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x647.10.1) (:span 13 20)))\n (:hscopes ((:id . :x647.10.1) (:span 13 188)))\n (:identifiers (:sid . :s647.10) (:did . :|10482545|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006010@unknown@formal@none@1@S@Interferons (IFNs) inhibit induction by IL-4 of multiple genes in human monocytes.@(((:tag . "NNP") (:stem . "Interferon") (:form . "Interferons") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s648.2) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006011@unknown@formal@none@1@S@However, the mechanism by which IFNs mediate this inhibition has not been defined.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ifn") (:form . "IFNs") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x648.3.1) (:span 65 68)))\n (:nscopes ((:id . :x648.3.1) (:span 9 81)))\n (:identifiers (:sid . :s648.3) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006012@unknown@formal@none@1@S@IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6 (signal transducer and activator of transcription-6).@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "homodimerization") (:form . "homodimerization")\n  (:end . 85) (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 112) (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 154)\n  (:start . 149) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 187)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription-6") (:form . "transcription-6")\n  (:end . 206) (:start . 191) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s648.4) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006013@unknown@formal@none@1@S@STAT6-responsive elements are characteristically present in the promoters of IL-4-inducible genes.@(((:tag . "JJ") (:stem . "stat6-responsive") (:form . "STAT6-responsive")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 25)\n  (:start . 17) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 44))\n ((:tag . "RB") (:stem . "characteristically") (:form . "characteristically")\n  (:end . 48) (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 56)\n  (:start . 49) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 73)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "il-4-inducible") (:form . "IL-4-inducible")\n  (:end . 91) (:start . 77) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s648.5) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006014@unknown@formal@none@1@S@Because STAT6 activation is essential for IL-4-induced gene expression, we examined the ability of type I and type II IFNs to regulate activation of STAT6 by IL-4 in primary human monocytes.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFNs") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 173)\n  (:start . 166) (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s648.6) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006015@unknown@formal@none@1@S@Pretreatment of monocytes with IFN-beta or IFN-gamma, but not IL-1, IL-2, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor, IL-6, or transforming growth factor beta suppressed activation of STAT6 by IL-4.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 103) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "granulocyte/macrophage")\n  (:form . "granulocyte/macrophage") (:end . 134) (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 153) (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 160)\n  (:start . 154) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 166) (:start . 162)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 183)\n  (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 190)\n  (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 197)\n  (:start . 191) (:id . 69))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 202) (:start . 198)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 213)\n  (:start . 203) (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 224)\n  (:start . 214) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 73))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 233)\n  (:start . 228) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 236) (:start . 234)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 241) (:start . 237)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x648.7.1) (:span 58 61)))\n (:nscopes ((:id . :x648.7.1) (:span 58 202)))\n (:identifiers (:sid . :s648.7) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006016@unknown@formal@none@1@S@This inhibition was associated with decreased tyrosine phosphorylation and nuclear translocation of STAT6 and was not evident unless the cells were preincubated with IFN for at least 1 hr before IL-4 stimulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 70) (:start . 55) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 96) (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 160)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 169) (:start . 166)\n  (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 182)\n  (:start . 177) (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 194)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 211)\n  (:start . 200) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x648.8.1) (:span 114 117)))\n (:nscopes ((:id . :x648.8.1) (:span 114 125)))\n (:identifiers (:sid . :s648.8) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006017@unknown@formal@none@1@S@Furthermore, inhibition by IFN could be blocked by cotreatment with actinomycin D and correlated temporally with induction of the JAK/STAT inhibitory gene, SOCS-1.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cotreatment") (:form . "cotreatment") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "RB") (:stem . "temporally") (:form . "temporally") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "JAK/STAT") (:form . "JAK/STAT") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 149)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "SOCS-1") (:form . "SOCS-1") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s648.9) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006018@unknown@formal@none@1@S@Forced expression of SOCS-1 in a macrophage cell line, RAW264, markedly suppressed trans-activation of an IL-4-inducible reporter as well as IL-6- and IFN-gamma-induced reporter gene activity.@(((:tag . "VBN") (:stem . "force") (:form . "Forced") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "socs-1") (:form . "SOCS-1") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RAW264") (:form . "RAW264") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 99) (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "il-4-inducible") (:form . "IL-4-inducible")\n  (:end . 120) (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-6-") (:form . "IL-6-") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 168) (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 177)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 182) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s648.10) (:did . :|10485906|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006020@unknown@formal@none@1@S@Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 61)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 82)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 113) (:start . 99) (:id . 54))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 123)\n  (:start . 114) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s649.1) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006021@unknown@formal@none@1@S@We have recently demonstrated that hydrocortisone and other glucocorticoids inhibit reactive oxygen species (ROS) generation by mononuclear (MNC) and polymorphonuclear leucocytes (PMNL).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 49) (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 75) (:start . 60) (:id . 50))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 83)\n  (:start . 76) (:id . 51))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 99)\n  (:start . 93) (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 107)\n  (:start . 100) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 139)\n  (:start . 128) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 167) (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "leucocyte") (:form . "leucocytes") (:end . 178)\n  (:start . 168) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "PMNL") (:form . "PMNL") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s649.2) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006022@unknown@formal@none@1@S@Since NF-kappaB/IkappaB system regulates the transcription of proinflammatory genes, including those responsible for ROS generation, we tested the hypothesis that hydrocortisone may stimulate IkappaB production thus inhibiting NF-kappaB translocation from the cytosol into the nucleus in MNC, in vivo.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB/IkappaB") (:form . "NF-kappaB/IkappaB")\n  (:end . 23) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 30)\n  (:start . 24) (:id . 44))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 77) (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 100) (:start . 95)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 112)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 120) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 131)\n  (:start . 121) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 135) (:start . 133)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 142)\n  (:start . 136) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 157)\n  (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 162) (:start . 158)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 177) (:start . 163) (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 181) (:start . 178)\n  (:id . 65))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 191)\n  (:start . 182) (:id . 66))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 199)\n  (:start . 192) (:id . 67))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 210)\n  (:start . 200) (:id . 68))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 215) (:start . 211)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 226)\n  (:start . 216) (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 236)\n  (:start . 227) (:id . 71))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 250) (:start . 237) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 255) (:start . 251)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 259) (:start . 256)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 267)\n  (:start . 260) (:id . 75))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 272) (:start . 268)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 276) (:start . 273)\n  (:id . 77))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 284)\n  (:start . 277) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 287) (:start . 285)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 291) (:start . 288)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 292) (:start . 291)\n  (:id . 81))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 295) (:start . 293)\n  (:id . 82))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 300) (:start . 296)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x649.3.1) (:span 178 181)))\n (:hscopes ((:id . :x649.3.1) (:span 178 210)))\n (:identifiers (:sid . :s649.3) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006023@unknown@formal@none@1@S@One hundred milligram of hydrocortisone was injected intravenously into 4 normal subjects.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "hundred") (:form . "hundred") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "milligram") (:form . "milligram") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 39) (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inject") (:form . "injected") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "RB") (:stem . "intravenously") (:form . "intravenously")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s649.4) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006024@unknown@formal@none@1@S@Blood samples were obtained prior to the injection and at 1, 2, 4, 8 and 24 hr after the injection.@(((:tag . "NNP") (:stem . "Blood") (:form . "Blood") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "prior") (:form . "prior") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 68) (:start . 67)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 59))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 75) (:start . 73)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 78) (:start . 76)\n  (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 84) (:start . 79)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 63))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 98)\n  (:start . 89) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s649.5) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006025@unknown@formal@none@1@S@Nuclear extracts and total cell lysates were prepared from MNC by standard techniques.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "technique") (:form . "techniques") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s649.6) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006026@unknown@formal@none@1@S@IkappaB levels in MNC homogenates increased at 1 hr, peaked at 2-4 hr, started to decrease at 8 hr, and returned to baseline levels at 24 hr.@(((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "homogenate") (:form . "homogenates") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "peak") (:form . "peaked") (:end . 59) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2-4") (:form . "2-4") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "start") (:form . "started") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 90)\n  (:start . 82) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 112)\n  (:start . 104) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 66))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 124)\n  (:start . 116) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 131)\n  (:start . 125) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 69))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 137) (:start . 135)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 140) (:start . 138)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s649.7) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006027@unknown@formal@none@1@S@NF-kappaB in MNC nuclear extracts decreased at 1 hr, reached a nadir at 4 hr, gradually increased at 8 hr and returned back to baseline levels at 24 hr.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "reach") (:form . "reached") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nadir") (:form . "nadir") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "RB") (:stem . "gradually") (:form . "gradually") (:end . 87)\n  (:start . 78) (:id . 59))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 97)\n  (:start . 88) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 105) (:start . 103)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 118)\n  (:start . 110) (:id . 65))\n ((:tag . "RB") (:stem . "back") (:form . "back") (:end . 123) (:start . 119)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 67))\n ((:tag . "NN") (:stem . "baseline") (:form . "baseline") (:end . 135)\n  (:start . 127) (:id . 68))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 142)\n  (:start . 136) (:id . 69))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 145) (:start . 143)\n  (:id . 70))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 148) (:start . 146)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 151) (:start . 149)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s649.8) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006028@unknown@formal@none@1@S@The total protein content of NF-kappaB subunit (P65) in MNC lysates also showed a decrease following hydrocortisone injection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "P65") (:form . "P65") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 79) (:start . 73)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 115) (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s649.9) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006030@unknown@formal@none@1@S@ROS generation inhibition paralleled NF-kappaB levels in the nucleus.@(((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "parallel") (:form . "paralleled") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 53)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s649.11) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006031@unknown@formal@none@1@S@It was inhibited at 1 hr, reached a nadir at 2-4 hr, started to increase at 8 hr, and returned to basal levels at 24 hr.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "reach") (:form . "reached") (:end . 33)\n  (:start . 26) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nadir") (:form . "nadir") (:end . 41) (:start . 36)\n  (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2-4") (:form . "2-4") (:end . 48) (:start . 45)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 51) (:start . 49)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "start") (:form . "started") (:end . 60)\n  (:start . 53) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 57))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 72)\n  (:start . 64) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 75) (:start . 73)\n  (:id . 59))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 77) (:start . 76)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 80) (:start . 78)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "return") (:form . "returned") (:end . 94)\n  (:start . 86) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 103) (:start . 98)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 110)\n  (:start . 104) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 113) (:start . 111)\n  (:id . 68))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 116) (:start . 114)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 119) (:start . 117)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s649.12) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006032@unknown@formal@none@1@S@Our data demonstrate that hydrocortisone induces IkappaB and suppresses NF-kappaB expression in MNC in parallel.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hydrocortisone") (:form . "hydrocortisone")\n  (:end . 40) (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 81)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MNC") (:form . "MNC") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s649.13) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006033@unknown@formal@none@1@S@IkappaB further reduces the translocation of NF-kappaB into the nucleus thus preventing the expression of proinflammatory genes.@(((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 102)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 121) (:start . 106) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 127)\n  (:start . 122) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s649.14) (:did . :|10487715|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006034@unknown@formal@none@1@S@Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells.@(((:tag . "JJ") (:stem . "renal") (:form . "Renal") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "carcinoma-derived") (:form . "carcinoma-derived")\n  (:end . 28) (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 50)\n  (:start . 42) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 58)\n  (:start . 51) (:id . 47))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 72) (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s650.1) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006035@unknown@formal@none@1@S@Activation of the transcription factor nuclear factor-kappaB (NFkappaB) is impaired in T cells from patients with renal cell carcinomas (RCCs).@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 60) (:start . 47) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "impair") (:form . "impaired") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "carcinoma") (:form . "carcinomas") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCCs") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s650.2) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006036@unknown@formal@none@1@S@In circulating T cells from a subset of patients with RCCs, the suppression of NFkappaB binding activity is downstream from the stimulus-induced degradation of the cytoplasmic factor IkappaBalpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCCs") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 75)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 118)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "stimulus-induced") (:form . "stimulus-induced")\n  (:end . 144) (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 156)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 175)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 195) (:start . 183) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s650.3) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006037@unknown@formal@none@1@S@Tumor-derived soluble products from cultured RCC explants inhibit NFkappaB activity in T cells from healthy volunteers, despite a normal level of stimulus-induced IkappaBalpha degradation in these cells.@(((:tag . "JJ") (:stem . "tumor-derived") (:form . "Tumor-derived")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "explant") (:form . "explants") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "volunteer") (:form . "volunteers") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "stimulus-induced") (:form . "stimulus-induced")\n  (:end . 162) (:start . 146) (:id . 64))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 175) (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 187)\n  (:start . 176) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 196)\n  (:start . 191) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s650.4) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006038@unknown@formal@none@1@S@The inhibitory agent has several features characteristic of a ganglioside, including sensitivity to neuraminidase but not protease treatment; hydrophobicity; and molecular weight less than 3 kDa.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 56) (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ganglioside") (:form . "ganglioside") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "neuraminidase") (:form . "neuraminidase")\n  (:end . 113) (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hydrophobicity") (:form . "hydrophobicity")\n  (:end . 156) (:start . 142) (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 157) (:start . 156)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 183) (:start . 179)\n  (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 190) (:start . 189)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x650.5.1) (:span 118 121)))\n (:nscopes ((:id . :x650.5.1) (:span 118 130)))\n (:identifiers (:sid . :s650.5) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006040@unknown@formal@none@1@S@Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.@(((:tag . "NNS") (:stem . "ganglioside") (:form . "Gangliosides") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 88)\n  (:start . 76) (:id . 54))\n ((:tag . "NNP") (:stem . "G(m1)") (:form . "G(m1)") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "G(d1a)") (:form . "G(d1a)") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 166)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 177)\n  (:start . 167) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 194)\n  (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 213)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s650.7) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006041@unknown@formal@none@1@S@Taken together, our findings suggest that tumor-derived gangliosides may blunt antitumor immune responses in patients with RCCs.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tumor-derived") (:form . "tumor-derived")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "ganglioside") (:form . "gangliosides") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "VB") (:stem . "blunt") (:form . "blunt") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antitumor") (:form . "antitumor") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 105)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCCs") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x650.8.1) (:span 69 72)) ((:id . :x650.8.2) (:span 29 36)))\n (:hscopes ((:id . :x650.8.1) (:span 69 127))\n  ((:id . :x650.8.2) (:span 29 127)))\n (:identifiers (:sid . :s650.8) (:did . :|10491412|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006042@unknown@formal@none@1@S@Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A [see comments]@(((:tag . "JJ") (:stem . "affinity-driven") (:form . "Affinity-driven")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 33)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s651.1) (:did . :|10497131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006043@unknown@formal@none@1@S@The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "calcium-mobilizing") (:form . "calcium-mobilizing")\n  (:end . 47) (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NFAT)-dependent") (:form . "NFAT)-dependent")\n  (:end . 113) (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 158)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 182)\n  (:start . 171) (:id . 66))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 194)\n  (:start . 183) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 216) (:start . 203) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 223)\n  (:start . 217) (:id . 71))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 228) (:start . 224)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s651.2) (:did . :|10497131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006044@unknown@formal@none@1@S@A high-affinity calcineurin-binding peptide was selected from combinatorial peptide libraries based on the calcineurin docking motif of NFAT.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "calcineurin-binding")\n  (:form . "calcineurin-binding") (:end . 35) (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 43)\n  (:start . 36) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "combinatorial") (:form . "combinatorial")\n  (:end . 75) (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 83)\n  (:start . 76) (:id . 50))\n ((:tag . "NNS") (:stem . "library") (:form . "libraries") (:end . 93)\n  (:start . 84) (:id . 51))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 99) (:start . 94)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 54))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 118)\n  (:start . 107) (:id . 55))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 126)\n  (:start . 119) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 132)\n  (:start . 127) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 140) (:start . 136)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s651.3) (:did . :|10497131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006045@unknown@formal@none@1@S@This peptide potently inhibited NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nfat-dependent") (:form . "NFAT-dependent")\n  (:end . 66) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 91)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 100)\n  (:start . 92) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 111) (:start . 110)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 170)\n  (:start . 161) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 183)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 195)\n  (:start . 184) (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 199) (:start . 196)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 208) (:start . 204)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x651.4.1) (:span 200 203))\n  ((:id . :x651.4.2) (:span 119 126)))\n (:nscopes ((:id . :x651.4.1) (:span 200 208))\n  ((:id . :x651.4.2) (:span 119 208)))\n (:identifiers (:sid . :s651.4) (:did . :|10497131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006046@unknown@formal@none@1@S@Substitution of the optimized peptide sequence into the natural calcineurin docking site increased the calcineurin responsiveness of NFAT.@(((:tag . "NN") (:stem . "substitution") (:form . "Substitution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "optimize") (:form . "optimized") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 129) (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 137) (:start . 133)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s651.5) (:did . :|10497131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006047@unknown@formal@none@1@S@Compounds that interfere selectively with the calcineurin-NFAT interaction without affecting calcineurin phosphatase activity may be useful as therapeutic agents that are less toxic than current drugs.@(((:tag . "NNS") (:stem . "compound") (:form . "Compounds") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "interfere") (:form . "interfere") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "calcineurin-nfat") (:form . "calcineurin-NFAT")\n  (:end . 62) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 74)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 82)\n  (:start . 75) (:id . 50))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 92)\n  (:start . 83) (:id . 51))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 104)\n  (:start . 93) (:id . 52))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 116)\n  (:start . 105) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 129) (:start . 126)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 132) (:start . 130)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 139)\n  (:start . 133) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 154)\n  (:start . 143) (:id . 59))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 161)\n  (:start . 155) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 170) (:start . 167)\n  (:id . 62))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 175) (:start . 171)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "toxic") (:form . "toxic") (:end . 181)\n  (:start . 176) (:id . 64))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 186) (:start . 182)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 194)\n  (:start . 187) (:id . 66))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 200)\n  (:start . 195) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x651.6.1) (:span 126 129)))\n (:ncues ((:id . :x651.6.2) (:span 75 82)))\n (:hscopes ((:id . :x651.6.1) (:span 126 200)))\n (:nscopes ((:id . :x651.6.2) (:span 75 125)))\n (:identifiers (:sid . :s651.6) (:did . :|10497131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006048@unknown@formal@none@1@S@NF-X2 that binds to the DRA X2-box is activator protein 1.@(((:tag . "NN") (:stem . "nf-x2") (:form . "NF-X2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "X2-box") (:form . "X2-box") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s652.1) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006050@unknown@formal@none@1@S@Human class II MHC Ag are a family of cell surface glycoproteins.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 50)\n  (:start . 43) (:id . 52))\n ((:tag . "NNS") (:stem . "glycoprotein") (:form . "glycoproteins")\n  (:end . 64) (:start . 51) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s652.3) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006051@unknown@formal@none@1@S@Their constitutive expression is limited to B lymphocytes and thymic epithelial cells.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s652.4) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006052@unknown@formal@none@1@S@In many other cells their expression can be induced by IFN-gamma.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 25)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s652.5) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006053@unknown@formal@none@1@S@Conserved upstream promoter sequences regulate this tissue-specific expression of class II genes.@(((:tag . "VBN") (:stem . "conserve") (:form . "Conserved") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 67) (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 87) (:start . 82)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s652.6) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006054@unknown@formal@none@1@S@In the DRA promoter, one of these cis-acting regulatory motifs is the X2-box to which nuclear factor X2 (NF-X2) binds.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 44)\n  (:start . 34) (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "x2-box") (:form . "X2-box") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nf-x2") (:form . "NF-X2") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s652.7) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006055@unknown@formal@none@1@S@Here, we present the isolation and characterization of the full-length cDNA clone encoding NF-X2.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 51) (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "nf-x2") (:form . "NF-X2") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s652.8) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006056@unknown@formal@none@1@S@This cDNA clone was isolated by expression cDNA cloning, and encodes the human c-Jun protein, which together with c-Fos forms the heterodimeric activator protein-1 transcription complex.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 143) (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 177) (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s652.9) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006057@unknown@formal@none@1@S@Whereas c-Fos/c-Jun heterodimers do not exist in B cells, they form and bind to the X2-box in class II nonexpressing cells.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-Fos/c-Jun") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "x2-box") (:form . "X2-box") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nonexpressing") (:form . "nonexpressing")\n  (:end . 116) (:start . 103) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x652.10.1) (:span 36 39)))\n (:nscopes ((:id . :x652.10.1) (:span 36 56)))\n (:identifiers (:sid . :s652.10) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006058@unknown@formal@none@1@S@Thus, c-Fos/c-Jun heterodimers might contribute to the repression of DRA gene expression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-Fos/c-Jun") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x652.11.1) (:span 31 36)))\n (:hscopes ((:id . :x652.11.1) (:span 31 88)))\n (:identifiers (:sid . :s652.11) (:did . :|1700011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006060@unknown@formal@none@1@S@Transient short-term expression of the Tax protein of human T-cell leukemia virus type-I (HTLV-I) leads to activation of the pleiotropic transcription factor NF-kappa B.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "short-term") (:form . "short-term") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "type-I") (:form . "type-I") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 150) (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 157)\n  (:start . 151) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s653.2) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006061@unknown@formal@none@1@S@Consistent with findings obtained with transient expression assays, we observed marked accumulation of the transcription factor NF-kappa B in the nucleus of Namalwa B lymphoid cells, which constitutively express Tax.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 99)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 153)\n  (:start . 146) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Namalwa") (:form . "Namalwa") (:end . 164)\n  (:start . 157) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 166) (:start . 165)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 203) (:start . 189) (:id . 71))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 211)\n  (:start . 204) (:id . 72))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 215) (:start . 212)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s653.3) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006062@unknown@formal@none@1@S@In contrast, NF-kappa B activity was not detected in the nucleus following long-term expression of Tax in Jurkat T lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 126)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x653.4.1) (:span 37 40)))\n (:nscopes ((:id . :x653.4.1) (:span 13 126)))\n (:identifiers (:sid . :s653.4) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006063@unknown@formal@none@1@S@The ability of both mitogens and cytokines to activate NF-kappa B was also blocked in Jurkat cells constitutively expressing Tax.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 113) (:start . 99) (:id . 59))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s653.5) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006064@unknown@formal@none@1@S@However, the activation of other mitogen-inducible transcription factors, such as Fos and Jun, was unaffected.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mitogen-inducible") (:form . "mitogen-inducible")\n  (:end . 50) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s653.6) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006065@unknown@formal@none@1@S@Thus, depending on the cellular environment, the short- and long-term effects of Tax expression can be quite different.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "short-") (:form . "short-") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x653.7.1) (:span 96 99)))\n (:hscopes ((:id . :x653.7.1) (:span 96 118)))\n (:identifiers (:sid . :s653.7) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006066@unknown@formal@none@1@S@Consequently, one function of Tax in cells infected with HTLV-I might involve cell-type-specific suppression, as opposed to activation, of distinct signal pathways.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 96) (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "oppose") (:form . "opposed") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 154)\n  (:start . 148) (:id . 65))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x653.8.1) (:span 64 69)))\n (:hscopes ((:id . :x653.8.1) (:span 64 163)))\n (:identifiers (:sid . :s653.8) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006067@unknown@formal@none@1@S@The cells lines described here should be useful for the delineation of signaling pathways utilized in the selective regulation of gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "delineation") (:form . "delineation") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x653.9.1) (:span 31 37)))\n (:hscopes ((:id . :x653.9.1) (:span 31 145)))\n (:identifiers (:sid . :s653.9) (:did . :|1964088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006068@unknown@formal@none@1@S@Stimulation of the human immunodeficiency virus type 2 (HIV-2) gene expression by the cytomegalovirus and HIV-2 transactivator gene.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 41) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 101) (:start . 86) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 126) (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s654.1) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006070@unknown@formal@none@1@S@Transactivation by some DNA viruses has been implicated in inducing HIV-1 replication and pathogenesis.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 102)\n  (:start . 90) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s654.3) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006071@unknown@formal@none@1@S@The transactivator (IE-2) gene of the human cytomegalovirus (CMV) can enhance HIV-2 as well as HIV-1 gene expression in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ie-2") (:form . "IE-2") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 59) (:start . 44) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 100)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 125)\n  (:start . 120) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s654.4) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006072@unknown@formal@none@1@S@This inducer can act in concert with the HIV-2 tat gene and T-cell activation in enhancing gene expression in human CD4+ lymphocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 132)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s654.5) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006073@unknown@formal@none@1@S@While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the HIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "VBP") (:stem . "employ") (:form . "employ") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "mode") (:form . "modes") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 127) (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 171)\n  (:start . 165) (:id . 69))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 182)\n  (:start . 172) (:id . 70))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "VB") (:stem . "employ") (:form . "employ") (:end . 193)\n  (:start . 187) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 195) (:start . 194)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 200) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 211)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 219)\n  (:start . 212) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 224) (:start . 220)\n  (:id . 77))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 229) (:start . 225)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 236)\n  (:start . 230) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 80))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 245) (:start . 241)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 254)\n  (:start . 246) (:id . 82))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 265)\n  (:start . 255) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x654.6.1) (:span 183 186)))\n (:hscopes ((:id . :x654.6.1) (:span 183 265)))\n (:identifiers (:sid . :s654.6) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006074@unknown@formal@none@1@S@Both HIV-2 and CMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation, with CMV transactivator affecting elongation more than the initiation.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 34) (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 83) (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 115)\n  (:start . 105) (:id . 55))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 126)\n  (:start . 116) (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 129) (:start . 127)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 134) (:start . 130)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 148)\n  (:start . 138) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 173) (:start . 159) (:id . 64))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 183)\n  (:start . 174) (:id . 65))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 194)\n  (:start . 184) (:id . 66))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 199) (:start . 195)\n  (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 204) (:start . 200)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 69))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 219)\n  (:start . 209) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s654.7) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006075@unknown@formal@none@1@S@A significant proportion of transcripts appear to terminate prematurely in the absence of transactivators.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VB") (:stem . "terminate") (:form . "terminate") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "RB") (:stem . "prematurely") (:form . "prematurely") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 105) (:start . 90) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x654.8.2) (:span 40 46)))\n (:ncues ((:id . :x654.8.1) (:span 79 86)))\n (:hscopes ((:id . :x654.8.2) (:span 0 105)))\n (:nscopes ((:id . :x654.8.1) (:span 79 105)))\n (:identifiers (:sid . :s654.8) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006076@unknown@formal@none@1@S@Deletion mutation analysis of the HIV-2 long terminal repeat (LTR) suggests that the element that responds to CMV transactivation in human CD4+ lymphocytes is either a diffuse one or located downstream of the HIV-2 enhancer element.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 129) (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "diffuse") (:form . "diffuse") (:end . 175)\n  (:start . 168) (:id . 70))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 190)\n  (:start . 183) (:id . 73))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 201)\n  (:start . 191) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 76))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 214)\n  (:start . 209) (:id . 77))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 223)\n  (:start . 215) (:id . 78))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 231)\n  (:start . 224) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x654.9.1) (:span 159 165 180 182))\n  ((:id . :x654.9.3) (:span 67 75)))\n (:hscopes ((:id . :x654.9.1) (:span 159 231))\n  ((:id . :x654.9.3) (:span 67 231)))\n (:identifiers (:sid . :s654.9) (:did . :|1972889|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006077@unknown@formal@none@1@S@Human immunodeficiency virus type-2 gene expression: two enhancers and their activation by T-cell activators.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type-2") (:form . "type-2") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 76)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s655.1) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006078@unknown@formal@none@1@S@The human immunodeficiency viruses (HIVs) may include a spectrum of retroviruses with varying potential to infect their host, undergo long periods of latent infection, and induce pathology.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 26) (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIVs") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "spectrum") (:form . "spectrum") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "retrovirus") (:form . "retroviruses") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "vary") (:form . "varying") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "VB") (:stem . "infect") (:form . "infect") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "period") (:form . "periods") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 178)\n  (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "pathology") (:form . "pathology") (:end . 188)\n  (:start . 179) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x655.2.1) (:span 42 45)))\n (:hscopes ((:id . :x655.2.1) (:span 42 188)))\n (:identifiers (:sid . :s655.2) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006080@unknown@formal@none@1@S@The HIV-2 LTR was found to contain two enhancers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s655.4) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006081@unknown@formal@none@1@S@One of these enhancers is, in part, identical to the HIV-1 enhancer.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 45)\n  (:start . 36) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 58) (:start . 53)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 67)\n  (:start . 59) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s655.5) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006082@unknown@formal@none@1@S@This enhancer in HIV-1 is the T-cell activation response element; in HIV-2, however, it is the second enhancer that is mainly responsible for activation in response to T-cell activators.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 110)\n  (:start . 102) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 125)\n  (:start . 119) (:id . 65))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 137)\n  (:start . 126) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 152)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 174)\n  (:start . 168) (:id . 72))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 185)\n  (:start . 175) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s655.6) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006083@unknown@formal@none@1@S@The second enhancer interacts with two nuclear binding proteins (85 kD and 27 kD mobility) that appear to be required for optimal enhancer function and activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "85") (:form . "85") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x655.7.1) (:span 96 102)))\n (:hscopes ((:id . :x655.7.1) (:span 91 162)))\n (:identifiers (:sid . :s655.7) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006084@unknown@formal@none@1@S@Observations such as these encourage the speculation that there may be subtle differences in the regulation of HIV-1 and HIV-2 expression that may be relevant to the possible longer latency and reduced pathogenicity of HIV-2.@(((:tag . "NNS") (:stem . "observation") (:form . "Observations") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "encourage") (:form . "encourage") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "speculation") (:form . "speculation") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "subtle") (:form . "subtle") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 158)\n  (:start . 150) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 181)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 189)\n  (:start . 182) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 201)\n  (:start . 194) (:id . 73))\n ((:tag . "NN") (:stem . "pathogenicity") (:form . "pathogenicity")\n  (:end . 215) (:start . 202) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x655.8.1) (:span 166 174))\n  ((:id . :x655.8.2) (:span 143 146)) ((:id . :x655.8.3) (:span 64 67))\n  ((:id . :x655.8.4) (:span 41 52)))\n (:hscopes ((:id . :x655.8.1) (:span 166 224))\n  ((:id . :x655.8.2) (:span 143 224)) ((:id . :x655.8.3) (:span 64 224))\n  ((:id . :x655.8.4) (:span 41 224)))\n (:identifiers (:sid . :s655.8) (:did . :|1981844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006085@unknown@formal@none@1@S@Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner.@(((:tag . "NNP") (:stem . "Purification") (:form . "Purification") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 46) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "context-dependent") (:form . "context-dependent")\n  (:end . 147) (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 154)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s656.1) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006086@unknown@formal@none@1@S@The differentiation of T cells into functionally diverse subpopulations is controlled in part, by transcriptional activation and silencing; however, little is known in detail about the proteins that influence this developmental process.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "subpopulation") (:form . "subpopulations")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 113) (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 174)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 180)\n  (:start . 175) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 198) (:start . 194)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "influence") (:form . "influence") (:end . 208)\n  (:start . 199) (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 213) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 227) (:start . 214) (:id . 75))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 235)\n  (:start . 228) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s656.2) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006087@unknown@formal@none@1@S@We have purified a new T-cell-specific factor, TCF-1 alpha, that is implicated in the activation of genes encoding a major component of the human T-cell receptor (TCR).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 38) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s656.3) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006088@unknown@formal@none@1@S@TCF-1 alpha, originally identified and purified through its binding sites on the HIV-1 promoter, was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta).@(((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . 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5006090@unknown@formal@none@1@S@Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines (Jurkat, CCRF-CEM) and not in mature B cells (JY, Namalwa) or nonlymphoid (HeLa) cell lines.@(((:tag . "NNP") (:stem . "Southwestern") (:form . "Southwestern") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "renaturation") (:form . "renaturation") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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5006091@unknown@formal@none@1@S@A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif) and the binding site for a distinct lymphoid-specific protein (TCF-2 alpha) behaved as a potent T-cell-specific enhancer in vivo.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "95-bp") (:form . "95-bp") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . 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5006092@unknown@formal@none@1@S@Tandem copies of this enhancer functioned synergistically in mature (Jurkat) T-cell lines as well as resting and activated immature (CCRF-CEM) T-cell lines.@(((:tag . "JJ") (:stem . "tandem") (:form . "Tandem") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "function") (:form . "functioned") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 57) (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CCRF-CEM") (:form . "CCRF-CEM") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 149)\n  (:start . 143) (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s656.8) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006093@unknown@formal@none@1@S@Mutation of the TCF-1 alpha binding site diminished enhancer activity and disrupted the synergism observed in vivo between tandem enhancer repeats.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "disrupt") (:form . "disrupted") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 146)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s656.9) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006094@unknown@formal@none@1@S@The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells, confirming that TCF-1 alpha is a T-cell-specific transcription factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 99) (:start . 82) (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "confirm") (:form . "confirming") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 169)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 196) (:start . 181) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 210) (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 217)\n  (:start . 211) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x656.10.1) (:span 132 135)))\n (:nscopes ((:id . :x656.10.1) (:span 132 146)))\n (:identifiers (:sid . :s656.10) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006095@unknown@formal@none@1@S@Curiously, the TCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the TCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter.@(((:tag . "RB") (:stem . "curiously") (:form . "Curiously") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "position") (:form . "positioned") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 169)\n  (:start . 163) (:id . 70))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 178)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 196)\n  (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 205)\n  (:start . 197) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s656.11) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006096@unknown@formal@none@1@S@Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 (CREB) transcription factors and the context of its binding site within the TCR alpha enhancer.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 25) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tcf-2") (:form . "TCF-2") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 145)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 152) (:start . 149)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 160)\n  (:start . 153) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 172)\n  (:start . 166) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 180) (:start . 177)\n  (:id . 75))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 186)\n  (:start . 181) (:id . 76))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 195)\n  (:start . 187) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x656.12.1) (:span 50 57)))\n (:hscopes ((:id . :x656.12.1) (:span 6 195)))\n (:identifiers (:sid . :s656.12) (:did . :|2083253|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006097@unknown@formal@none@1@S@A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 30) (:start . 15) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "ester-inducible") (:form . "ester-inducible")\n  (:end . 72) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 101) (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s657.1) (:did . :|2088505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006098@unknown@formal@none@1@S@The interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 82) (:start . 64) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 113) (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "integrate") (:form . "integrate") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 151)\n  (:start . 140) (:id . 61))\n ((:tag . "VBN") (:stem . "transmit") (:form . "transmitted") (:end . 163)\n  (:start . 152) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 174)\n  (:start . 167) (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 184)\n  (:start . 175) (:id . 65))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 192)\n  (:start . 185) (:id . 66))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 200)\n  (:start . 193) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 208) (:start . 204)\n  (:id . 69))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 219)\n  (:start . 209) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 223) (:start . 220)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 230)\n  (:start . 224) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 241)\n  (:start . 231) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s657.2) (:did . :|2088505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006100@unknown@formal@none@1@S@Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tce") (:form . "TCE") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 79)\n  (:start . 72) (:id . 57))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 120)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x657.4.1) (:span 89 102)))\n (:hscopes ((:id . :x657.4.1) (:span 89 136)))\n (:identifiers (:sid . :s657.4) (:did . :|2088505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006101@unknown@formal@none@1@S@However, like NF kappa B, TCF-1 activity is induced by phorbol esters and other T-cell activators.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tcf-1") (:form . "TCF-1") (:end . 31) (:start . 26)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 40)\n  (:start . 32) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s657.5) (:did . :|2088505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006102@unknown@formal@none@1@S@Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 63) (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "microe5/kappa") (:form . "microE5/kappa")\n  (:end . 86) (:start . 73) (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 88) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s658.1) (:did . :|2105528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006103@unknown@formal@none@1@S@Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins.@(((:tag . "NN") (:stem . "activity") (:form . "Activity") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "heavy") (:form . "heavy") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 138) (:start . 123) (:id . 61))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s658.2) (:did . :|2105528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006104@unknown@formal@none@1@S@Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "dna") (:form . "DNAs") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "encode") (:form . "encode") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "denote") (:form . "denoted") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "itf-1") (:form . "ITF-1") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "itf-2") (:form . "ITF-2") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "microe5/kappa") (:form . "microE5/kappa")\n  (:end . 156) (:start . 143) (:id . 68))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 178) (:start . 174)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 194)\n  (:start . 189) (:id . 76))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 200)\n  (:start . 195) (:id . 77))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 206)\n  (:start . 201) (:id . 78))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 216)\n  (:start . 207) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s658.3) (:did . :|2105528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006105@unknown@formal@none@1@S@The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "dna") (:form . "DNAs") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "yet") (:form . "yet") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "itf-1") (:form . "ITF-1") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "itf-2") (:form . "ITF-2") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 100)\n  (:start . 88) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 117)\n  (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s658.4) (:did . :|2105528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006106@unknown@formal@none@1@S@The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 56)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 82) (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "possess") (:form . "possesses") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "dictate") (:form . "dictates") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 154) (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s658.5) (:did . :|2105528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006107@unknown@formal@none@1@S@A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 98)\n  (:start . 86) (:id . 58))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s659.1) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006108@unknown@formal@none@1@S@The transcriptional enhancer located in the first intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 78) (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 148) (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 177) (:start . 163) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 183)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s659.2) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006110@unknown@formal@none@1@S@Each binding site contributes to the overall activity of the enhancer, however no single element seems absolutely required for activity.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 12) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "RB") (:stem . "absolutely") (:form . "absolutely") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x659.4.2) (:span 97 102)))\n (:ncues ((:id . :x659.4.1) (:span 79 81)))\n (:hscopes ((:id . :x659.4.2) (:span 79 135)))\n (:nscopes ((:id . :x659.4.1) (:span 79 135)))\n (:identifiers (:sid . :s659.4) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006111@unknown@formal@none@1@S@For a better understanding of the Ig heavy chain enhancer components, we have cloned and analyzed individual sequence elements.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s659.5) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006112@unknown@formal@none@1@S@We find that the factor that binds to the E3 enhancer motif, CATGTGGC, is a ubiquitous transcription factor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 53)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CATGTGGC") (:form . "CATGTGGC") (:end . 69)\n  (:start . 61) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 86)\n  (:start . 76) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s659.6) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006113@unknown@formal@none@1@S@It is present in an active form in both B cells and non-B cells, where it can mediate transcriptional activation in vitro and in vivo.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 70) (:start . 65)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 73) (:start . 71)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 77) (:start . 74)\n  (:id . 59))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 85)\n  (:start . 78) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s659.7) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006114@unknown@formal@none@1@S@However, despite its ability to activate transcription of a transfected reporter gene, the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in non-lymphoid cells: In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3, was detected in B cells but not in non-B cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "non-lymphoid") (:form . "non-lymphoid") (:end . 184)\n  (:start . 172) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 190)\n  (:start . 185) (:id . 72))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 191) (:start . 190)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 194) (:start . 192)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 203)\n  (:start . 195) (:id . 75))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 215)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 225)\n  (:start . 219) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 245) (:start . 231) (:id . 81))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 248) (:start . 246)\n  (:id . 82))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 253) (:start . 249)\n  (:id . 83))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 263)\n  (:start . 254) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 266) (:start . 264)\n  (:id . 85))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 271) (:start . 267)\n  (:id . 86))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 278)\n  (:start . 272) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 279) (:start . 278)\n  (:id . 88))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 290)\n  (:start . 280) (:id . 89))\n ((:tag . "NNP") (:stem . "NF-muE3") (:form . "NF-muE3") (:end . 298)\n  (:start . 291) (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 299) (:start . 298)\n  (:id . 91))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 303) (:start . 300)\n  (:id . 92))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 312)\n  (:start . 304) (:id . 93))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 315) (:start . 313)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 317) (:start . 316)\n  (:id . 95))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 323)\n  (:start . 318) (:id . 96))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 327) (:start . 324)\n  (:id . 97))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 331) (:start . 328)\n  (:id . 98))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 334) (:start . 332)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 340)\n  (:start . 335) (:id . 100))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 346)\n  (:start . 341) (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 347) (:start . 346)\n  (:id . 102)))@@@1@61@((:hcues ((:id . :x659.8.3) (:span 101 111)))\n (:ncues ((:id . :x659.8.1) (:span 328 331))\n  ((:id . :x659.8.2) (:span 112 118)))\n (:hscopes ((:id . :x659.8.3) (:span 87 190)))\n (:nscopes ((:id . :x659.8.1) (:span 328 346))\n  ((:id . :x659.8.2) (:span 87 190)))\n (:identifiers (:sid . :s659.8) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006115@unknown@formal@none@1@S@From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes: (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors, exemplified by the one binding to the E3 sequence motif.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . 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5006116@unknown@formal@none@1@S@This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous Ig heavy chain enhancer in non-B cells, perhaps due to a non-permissive chromatin structure of the Ig heavy chain locus.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 67) (:start . 62)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 85)\n  (:start . 75) (:id . 58))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 118)\n  (:start . 108) (:id . 64))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 127)\n  (:start . 122) (:id . 66))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 133)\n  (:start . 128) (:id . 67))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 142)\n  (:start . 134) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 72))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 166)\n  (:start . 159) (:id . 73))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 170) (:start . 167)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 175) (:start . 174)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "non-permissive") (:form . "non-permissive")\n  (:end . 190) (:start . 176) (:id . 77))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 200)\n  (:start . 191) (:id . 78))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 210)\n  (:start . 201) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 220) (:start . 218)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 226)\n  (:start . 221) (:id . 83))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 232)\n  (:start . 227) (:id . 84))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 238)\n  (:start . 233) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x659.10.1) (:span 159 166))\n  ((:id . :x659.10.3) (:span 75 85)))\n (:ncues ((:id . :x659.10.2) (:span 86 92)))\n (:hscopes ((:id . :x659.10.1) (:span 159 238))\n  ((:id . :x659.10.3) (:span 72 157)))\n (:nscopes ((:id . :x659.10.2) (:span 72 157)))\n (:identifiers (:sid . :s659.10) (:did . :|2105887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006117@unknown@formal@none@1@S@Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 40) (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 51)\n  (:start . 41) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 60) (:start . 55)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 78)\n  (:start . 72) (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 88)\n  (:start . 79) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 104) (:start . 89) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 53))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 121)\n  (:start . 114) (:id . 54))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 130)\n  (:start . 122) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s660.1) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006118@unknown@formal@none@1@S@AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).@(((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 21)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 180)\n  (:start . 174) (:id . 69))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 225) (:start . 189)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 230) (:start . 227)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 231) (:start . 230)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s660.2) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006120@unknown@formal@none@1@S@Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "reach") (:form . "reached") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 172) (:start . 170)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s660.4) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006121@unknown@formal@none@1@S@Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s660.5) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006122@unknown@formal@none@1@S@Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bryostatin") (:form . "bryostatin") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 120)\n  (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 136) (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s660.6) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006123@unknown@formal@none@1@S@Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 34) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 132) (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s660.7) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006124@unknown@formal@none@1@S@TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts.@(((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 61) (:start . 48) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "superinduction") (:form . "superinduction")\n  (:end . 96) (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 117)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s660.8) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006125@unknown@formal@none@1@S@Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold.@(((:tag . "JJ") (:stem . "run-on") (:form . "Run-on") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 46)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 93) (:start . 88)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "RB") (:stem . "3.3-fold") (:form . "3.3-fold") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s660.9) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006126@unknown@formal@none@1@S@Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x660.10.1) (:span 61 63)))\n (:nscopes ((:id . :x660.10.1) (:span 61 106)))\n (:identifiers (:sid . :s660.10) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006127@unknown@formal@none@1@S@The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "treat") (:form . "treating") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "actinomycin") (:form . "actinomycin") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s660.11) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006128@unknown@formal@none@1@S@In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tpa-treated") (:form . "TPA-treated") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s660.12) (:did . :|2105946|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006130@unknown@formal@none@1@S@Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 70) (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 135)\n  (:start . 124) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 153)\n  (:start . 145) (:id . 61))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 167) (:start . 154) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 174)\n  (:start . 168) (:id . 63))\n ((:tag . "NN") (:stem . "otf2") (:form . "OTF2") (:end . 179) (:start . 175)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s661.1) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006131@unknown@formal@none@1@S@The tissue-specific expression of the MOPC 141 immunoglobulin heavy-chain gene was studied by using in vitro transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MOPC") (:form . "MOPC") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "CD") (:stem . "141") (:form . "141") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 61) (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s661.2) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006132@unknown@formal@none@1@S@B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3', located in the upstream region of this promoter and in the promoters of all other immunoglobulin heavy- and light-chain genes.@(((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NNP") (:stem . "5'-ATGCAAAG-3") (:form . "5'-ATGCAAAG-3")\n  (:end . 93) (:start . 80) (:id . 53))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 164)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 192) (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "heavy-") (:form . "heavy-") (:end . 199)\n  (:start . 193) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "light-chain") (:form . "light-chain") (:end . 215)\n  (:start . 204) (:id . 74))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 221)\n  (:start . 216) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s661.3) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006133@unknown@formal@none@1@S@The interaction of purified octamer transcription factors 1 and 2 (OTF1 and OTF2) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "OTF1") (:form . "OTF1") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "OTF2") (:form . "OTF2") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MOPC") (:form . "MOPC") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "CD") (:stem . "141") (:form . "141") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 129) (:start . 124)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 145) (:start . 130) (:id . 66))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 192)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s661.4) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006134@unknown@formal@none@1@S@Purified OTF1 from HeLa cells and OTF1 and OTF2 from B cells bound to identical sequences within the heavy-chain promoter.@(((:tag . "VBN") (:stem . "purify") (:form . "Purified") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "OTF1") (:form . "OTF1") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "otf1") (:form . "OTF1") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "otf2") (:form . "OTF2") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 112)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s661.5) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006135@unknown@formal@none@1@S@The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3', and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "OTF") (:form . "OTF") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "extend") (:form . "extended") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "5'-CTCAGGA-3") (:form . "5'-CTCAGGA-3") (:end . 80)\n  (:start . 68) (:id . 52))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 164)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 216)\n  (:start . 208) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x661.6.1) (:span 96 102)) ((:id . :x661.6.2) (:span 90 95)))\n (:hscopes ((:id . :x661.6.1) (:span 96 216))\n  ((:id . :x661.6.2) (:span 90 216)))\n (:identifiers (:sid . :s661.6) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006136@unknown@formal@none@1@S@In addition to these elements, we identified a second regulatory element, the N element with the sequence 5'-GGAACCTCCCCC-3'.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "5'-ggaacctccccc-3") (:form . "5'-GGAACCTCCCCC-3")\n  (:end . 123) (:start . 106) (:id . 61))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s661.7) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006137@unknown@formal@none@1@S@The N element could independently mediate low levels of transcription in both B-cell and HeLa-cell extracts, and, in conjunction with the octamer element, it can promote high levels of transcription in B-cell extracts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hela-cell") (:form . "HeLa-cell") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 145)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 153)\n  (:start . 146) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 169)\n  (:start . 162) (:id . 70))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 181)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 198) (:start . 185) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 208)\n  (:start . 202) (:id . 76))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 217)\n  (:start . 209) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s661.8) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006138@unknown@formal@none@1@S@The N element bound a transcription factor, NTF, that is ubiquitous in cell-type distribution, and NTF was distinct from any of the previously described proteins that bind to similar sequences.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NTF") (:form . "NTF") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 67)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 93)\n  (:start . 81) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NTF") (:form . "NTF") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 115)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 142)\n  (:start . 132) (:id . 67))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 152)\n  (:start . 143) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 182)\n  (:start . 175) (:id . 73))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 192)\n  (:start . 183) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s661.9) (:did . :|2109187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006140@unknown@formal@none@1@S@Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 41) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 94) (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 106)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 111) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s662.1) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006141@unknown@formal@none@1@S@To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene, we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor, designated NF-microB, in the murine IgH enhancer.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "OCTA)-nucleotide") (:form . "OCTA)-nucleotide")\n  (:end . 100) (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 142) (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 175) (:start . 161) (:id . 64))\n ((:tag . "NN") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 187)\n  (:start . 176) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 192) (:start . 189)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 198) (:start . 194)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 220)\n  (:start . 208) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 74))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 231)\n  (:start . 225) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "mutate") (:form . "mutating") (:end . 243)\n  (:start . 235) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 78))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 255)\n  (:start . 248) (:id . 79))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 260) (:start . 256)\n  (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 264) (:start . 261)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 266) (:start . 265)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 275)\n  (:start . 267) (:id . 83))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 286)\n  (:start . 276) (:id . 84))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 304) (:start . 287) (:id . 85))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 318) (:start . 305) (:id . 86))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 325)\n  (:start . 319) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 326) (:start . 325)\n  (:id . 88))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 337)\n  (:start . 327) (:id . 89))\n ((:tag . "NNP") (:stem . "NF-microB") (:form . "NF-microB") (:end . 347)\n  (:start . 338) (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 348) (:start . 347)\n  (:id . 91))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 351) (:start . 349)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 355) (:start . 352)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 362)\n  (:start . 356) (:id . 94))\n ((:tag . "NN") (:stem . "igh") (:form . "IgH") (:end . 366) (:start . 363)\n  (:id . 95))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 375)\n  (:start . 367) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 376) (:start . 375)\n  (:id . 97)))@@@1@56@((:hcues ((:id . :x662.2.1) (:span 13 20)))\n (:hscopes ((:id . :x662.2.1) (:span 13 198)))\n (:identifiers (:sid . :s662.2) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006142@unknown@formal@none@1@S@We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer, because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nf-microb-binding") (:form . "NF-microB-binding")\n  (:end . 41) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 156) (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 185)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 208)\n  (:start . 202) (:id . 75))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 216)\n  (:start . 209) (:id . 76))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 220) (:start . 217)\n  (:id . 77))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 224) (:start . 221)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 239)\n  (:start . 228) (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 245)\n  (:start . 240) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x662.3.1) (:span 221 224)))\n (:nscopes ((:id . :x662.3.1) (:span 221 245)))\n (:identifiers (:sid . :s662.3) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006143@unknown@formal@none@1@S@This effect was comparable to or even stronger than the effect of a mutation in the OCTA site.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "OCTA") (:form . "OCTA") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s662.4) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006144@unknown@formal@none@1@S@Moreover, combined mutation of both microB and OCTA sites further reduced enhancer activity in lymphoid cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "microB") (:form . "microB") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "OCTA") (:form . "OCTA") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s662.5) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006145@unknown@formal@none@1@S@Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "70-base-pair") (:form . "70-base-pair") (:end . 75)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "OCTA") (:form . "OCTA") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 151)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 198)\n  (:start . 188) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x662.6.1) (:span 110 115)))\n (:nscopes ((:id . :x662.6.1) (:span 110 141)))\n (:identifiers (:sid . :s662.6) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006146@unknown@formal@none@1@S@Nevertheless, a multimer of the microB motif alone showed no enhancer activity.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "multimer") (:form . "multimer") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 57) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x662.7.1) (:span 58 60)))\n (:nscopes ((:id . :x662.7.1) (:span 58 78)))\n (:identifiers (:sid . :s662.7) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006147@unknown@formal@none@1@S@DNase footprinting analysis corroborated the functional data showing that a lymphoid-specific protein binds to the microB DNA motif.@(((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "corroborate") (:form . "corroborated") (:end . 40)\n  (:start . 28) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 68)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 93) (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 53))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 107)\n  (:start . 102) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 131)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s662.8) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006148@unknown@formal@none@1@S@Our results suggest that the microB element is a new crucial element important for lymphoid-specific expression of the IgH gene but that interaction with another enhancer element is essential for its activity.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 100) (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 148)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 208)\n  (:start . 200) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x662.9.1) (:span 12 19)))\n (:hscopes ((:id . :x662.9.1) (:span 12 208)))\n (:identifiers (:sid . :s662.9) (:did . :|2111447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006150@unknown@formal@none@1@S@The effect of heat shock on the expression of the nuclear protooncogenes c-fos, c-jun, and c-myc was studied in human lymphoid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "protooncogene") (:form . "protooncogenes")\n  (:end . 72) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s663.2) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006151@unknown@formal@none@1@S@Heat shock caused an increase in c-fos and c-jun mRNA levels and a decrease in c-myc mRNA levels in pre-B (Hyon) and T (DND-41) cell lines as well as in freshly isolated normal human thymocytes.@(((:tag . "NNP") (:stem . "Heat") (:form . "Heat") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Hyon") (:form . "Hyon") (:end . 111) (:start . 107)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 67))\n ((:tag . "NN") (:stem . "dnd-41") (:form . "DND-41") (:end . 126)\n  (:start . 120) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 132) (:start . 128)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 138)\n  (:start . 133) (:id . 71))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 141) (:start . 139)\n  (:id . 72))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 146) (:start . 142)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 149) (:start . 147)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 75))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 160)\n  (:start . 153) (:id . 76))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 169)\n  (:start . 161) (:id . 77))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 176)\n  (:start . 170) (:id . 78))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 182)\n  (:start . 177) (:id . 79))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 193)\n  (:start . 183) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s663.3) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006152@unknown@formal@none@1@S@The changes in the mRNA levels of these protooncogenes in Hyon cells were most pronounced at 42 and 43 degrees C; kinetic analysis demonstrated that the changes could be detected within 30 min of heat shock.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protooncogene") (:form . "protooncogenes")\n  (:end . 54) (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Hyon") (:form . "Hyon") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "43") (:form . "43") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "JJ") (:stem . "c") (:form . "C") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "kinetic") (:form . "kinetic") (:end . 121)\n  (:start . 114) (:id . 64))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 143)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 160)\n  (:start . 153) (:id . 69))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 178)\n  (:start . 170) (:id . 72))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 185)\n  (:start . 179) (:id . 73))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 200) (:start . 196)\n  (:id . 77))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 206)\n  (:start . 201) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s663.4) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006153@unknown@formal@none@1@S@Altered transcription of c-fos and c-myc genes was the primary effect of heat shock.@(((:tag . "JJ") (:stem . "altered") (:form . "Altered") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s663.5) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006154@unknown@formal@none@1@S@Secondarily, heat shock of Hyon cells stabilized the c-myc mRNA level by increasing its half-life from 24 to 45 min.@(((:tag . "RB") (:stem . "secondarily") (:form . "Secondarily") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Hyon") (:form . "Hyon") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "stabilize") (:form . "stabilized") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s663.6) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006155@unknown@formal@none@1@S@The overall effect of heat shock on c-myc mRNA level, however, was a marked inhibition of its transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 75)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 86)\n  (:start . 76) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s663.7) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006156@unknown@formal@none@1@S@These results demonstrate that the transcription of nuclear protooncogenes is regulated by heat shock indicating a role for nuclear protooncogenes in the stress response of lymphoid cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "protooncogene") (:form . "protooncogenes")\n  (:end . 74) (:start . 60) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "protooncogene") (:form . "protooncogenes")\n  (:end . 146) (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 160)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 169)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 181)\n  (:start . 173) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x663.8.1) (:span 102 112)))\n (:hscopes ((:id . :x663.8.1) (:span 102 187)))\n (:identifiers (:sid . :s663.8) (:did . :|2112575|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006157@unknown@formal@none@1@S@Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.@(((:tag . "JJ") (:stem . "tandem") (:form . "Tandem") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s664.1) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006158@unknown@formal@none@1@S@A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "18-bp") (:form . "18-bp") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "NN") (:stem . "epsilon-globin") (:form . "epsilon-globin")\n  (:end . 104) (:start . 90) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 129)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "locus-activating") (:form . "locus-activating")\n  (:end . 157) (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s664.2) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006160@unknown@formal@none@1@S@The enhancer consists of tandem AP-1-binding sites, phased 10 bp apart, which are both required for full activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "phase") (:form . "phased") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "apart") (:form . "apart") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s664.4) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006161@unknown@formal@none@1@S@DNA-protein binding assays with nuclear extracts from induced cells demonstrate a high molecular weight complex on the enhancer.@(((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 79)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s664.5) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006162@unknown@formal@none@1@S@The formation of this complex also requires both AP-1 sites and correlates with maximal enhancer activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s664.6) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006163@unknown@formal@none@1@S@Induction of the enhancer may have a role in the increase in globin gene transcription that characterizes erythroid maturation.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 86) (:start . 73) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "characterize") (:form . "characterizes")\n  (:end . 105) (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x664.7.1) (:span 26 29)))\n (:hscopes ((:id . :x664.7.1) (:span 26 126)))\n (:identifiers (:sid . :s664.7) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006164@unknown@formal@none@1@S@Enhancer activity appears to be mediated by the binding of a complex of proteins from the jun and fos families to tandem AP-1 consensus sequences.@(((:tag . "NNP") (:stem . "Enhancer") (:form . "Enhancer") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 135)\n  (:start . 126) (:id . 65))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 145)\n  (:start . 136) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x664.8.1) (:span 18 25)))\n (:hscopes ((:id . :x664.8.1) (:span 0 145)))\n (:identifiers (:sid . :s664.8) (:did . :|2116990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006165@unknown@formal@none@1@S@Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA.@(((:tag . "JJ") (:stem . "adherence-dependent")\n  (:form . "Adherence-dependent") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 28)\n  (:start . 20) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EGR2") (:form . "EGR2") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s665.1) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006166@unknown@formal@none@1@S@Adherence is an important initial step in the transition of a circulating monocyte to a tissue macrophage.@(((:tag . "NNP") (:stem . "Adherence") (:form . "Adherence") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s665.2) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006167@unknown@formal@none@1@S@This differentiation is accompanied by an augmented capacity to generate growth factors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "augmented") (:form . "augmented") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s665.3) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006168@unknown@formal@none@1@S@We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit (PDGF[B]) and transforming growth factor-beta (TGF-beta).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "trigger") (:form . "trigger") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "VBG") (:stem . "culminate") (:form . "culminating") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "JJ") (:stem . "profibrotic") (:form . "profibrotic") (:end . 163)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 178)\n  (:start . 171) (:id . 67))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 183) (:start . 179)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 186) (:start . 184)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "platelet-derived") (:form . "platelet-derived")\n  (:end . 203) (:start . 187) (:id . 70))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 210)\n  (:start . 204) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 217)\n  (:start . 211) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 219) (:start . 218)\n  (:id . 73))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 227)\n  (:start . 220) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "PDGF[B") (:form . "PDGF[B") (:end . 235)\n  (:start . 229) (:id . 76))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 236) (:start . 235)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 237) (:start . 236)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 241) (:start . 238)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 254)\n  (:start . 242) (:id . 80))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 261)\n  (:start . 255) (:id . 81))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 273)\n  (:start . 262) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 275) (:start . 274)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 283)\n  (:start . 275) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 284) (:start . 283)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 285) (:start . 284)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x665.4.1) (:span 38 43)))\n (:hscopes ((:id . :x665.4.1) (:span 38 284)))\n (:identifiers (:sid . :s665.4) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006170@unknown@formal@none@1@S@No increase in TGF-beta mRNA was observed.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x665.6.1) (:span 0 2)))\n (:nscopes ((:id . :x665.6.1) (:span 0 41)))\n (:identifiers (:sid . :s665.6) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006171@unknown@formal@none@1@S@The 6-h increase in PDGF(B) mRNA was adherence dependent, and in addition, was abrogated when the cytoskeletal integrity was compromised by cytochalasin D.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "6-h") (:form . "6-h") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cytoskeletal") (:form . "cytoskeletal") (:end . 110)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "integrity") (:form . "integrity") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "compromise") (:form . "compromised") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytochalasin") (:form . "cytochalasin") (:end . 152)\n  (:start . 140) (:id . 65))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s665.7) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006172@unknown@formal@none@1@S@The 6-h increase in PDGF(B) mRNA was unaltered by adherence in the presence of the monocyte stimulus lipopolysaccharide.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "6-h") (:form . "6-h") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 119) (:start . 101) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s665.8) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006173@unknown@formal@none@1@S@Adherence to either fibronectin or collagen-coated plastic had little consistent effect on PDGF(B) mRNA accumulation.@(((:tag . "NNP") (:stem . "Adherence") (:form . "Adherence") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "collagen-coated") (:form . "collagen-coated")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "plastic") (:form . "plastic") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 116)\n  (:start . 104) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s665.9) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006174@unknown@formal@none@1@S@The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 163)\n  (:start . 158) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "egr2") (:form . "EGR2") (:end . 173) (:start . 169)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 182)\n  (:start . 175) (:id . 75))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 185) (:start . 183)\n  (:id . 76))\n ((:tag . "CD") (:stem . "6-24") (:form . "6-24") (:end . 190) (:start . 186)\n  (:id . 77))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 192) (:start . 191)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 193) (:start . 192)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s665.10) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006175@unknown@formal@none@1@S@The increase in c-jun and EGR2, but not c-fos, mRNA was also abrogated by cytochalasin D.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "egr2") (:form . "EGR2") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 60) (:start . 56)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 70)\n  (:start . 61) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cytochalasin") (:form . "cytochalasin") (:end . 86)\n  (:start . 74) (:id . 58))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x665.11.1) (:span 36 39)))\n (:nscopes ((:id . :x665.11.1) (:span 36 45)))\n (:identifiers (:sid . :s665.11) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006176@unknown@formal@none@1@S@These observations suggest that adherence results in increases of c-fos, c-jun, EGR2, and PDGF(B) mRNA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EGR2") (:form . "EGR2") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x665.12.1) (:span 19 26)))\n (:hscopes ((:id . :x665.12.1) (:span 19 102)))\n (:identifiers (:sid . :s665.12) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006177@unknown@formal@none@1@S@In addition, the increases in c-jun, EGR2, and PDGF(B) may depend on cytoskeletal rearrangement.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EGR2") (:form . "EGR2") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PDGF(B)") (:form . "PDGF(B)") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 65)\n  (:start . 59) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cytoskeletal") (:form . "cytoskeletal") (:end . 81)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 95) (:start . 82) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x665.13.1) (:span 55 58)))\n (:hscopes ((:id . :x665.13.1) (:span 55 95)))\n (:identifiers (:sid . :s665.13) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006178@unknown@formal@none@1@S@Modulation of these events at the time of adherence offers a mechanism by which differential priming of the cells may be accomplished.@(((:tag . "NN") (:stem . "modulation") (:form . "Modulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "VBZ") (:stem . "offer") (:form . "offers") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "accomplish") (:form . "accomplished") (:end . 133)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x665.14.1) (:span 114 117)))\n (:hscopes ((:id . :x665.14.1) (:span 80 133)))\n (:identifiers (:sid . :s665.14) (:did . :|2121746|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006180@unknown@formal@none@1@S@The sexual difference in the incidence of autoimmune diseases has remained an enigma for many years.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "sexual") (:form . "sexual") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "incidence") (:form . "incidence") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "remain") (:form . "remained") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enigma") (:form . "enigma") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s666.2) (:did . :|2122173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006181@unknown@formal@none@1@S@In the examination of the induction of autoimmunity in transgenic mice, evidence has been obtained further implicating the lymphokine interferon-gamma in the etiology of autoimmunity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "examination") (:form . "examination") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "autoimmunity") (:form . "autoimmunity") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 150) (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "etiology") (:form . "etiology") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "autoimmunity") (:form . "autoimmunity") (:end . 182)\n  (:start . 170) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s666.3) (:did . :|2122173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006182@unknown@formal@none@1@S@Sex steroid regulation of the production of this molecule, as well as other cytokines, may help explain the gender-specific differences in the immune system, including autoimmunity.@(((:tag . "NN") (:stem . "sex") (:form . "Sex") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "gender-specific") (:form . "gender-specific")\n  (:end . 123) (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 135)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 149)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "autoimmunity") (:form . "autoimmunity") (:end . 180)\n  (:start . 168) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x666.4.1) (:span 87 90)))\n (:hscopes ((:id . :x666.4.1) (:span 87 180)))\n (:identifiers (:sid . :s666.4) (:did . :|2122173|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006183@unknown@formal@none@1@S@Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.@(((:tag . "JJ") (:stem . "single") (:form . "Single") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "VBG") (:stem . "emanate") (:form . "emanating") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s667.1) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006184@unknown@formal@none@1@S@Stimulation of T lymphocytes through their antigen receptor leads to the appearance of several transcription factors, including NF-AT and NF-kappa B, which are involved in regulating genes required for immunologic activation.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 42)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 197)\n  (:start . 189) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 213)\n  (:start . 202) (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 224)\n  (:start . 214) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s667.2) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006185@unknown@formal@none@1@S@To investigate the activity of a single transcription factor in individual viable cells, we have applied an assay that uses the fluorescence-activated cell sorter to quantitate beta-galactosidase (beta-gal).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "fluorescence-activated")\n  (:form . "fluorescence-activated") (:end . 150) (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "sorter") (:form . "sorter") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "VB") (:stem . "quantitate") (:form . "quantitate") (:end . 176)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "beta-galactosidase") (:form . "beta-galactosidase")\n  (:end . 195) (:start . 177) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "beta-gal") (:form . "beta-gal") (:end . 205)\n  (:start . 197) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s667.3) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006186@unknown@formal@none@1@S@We have analyzed the distribution of NF-AT transcriptional activity among T cells undergoing activation by using a construct in which three tandem copies of the NF-AT-binding site directs transcription of the lacZ gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 58) (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 112) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 153)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 174) (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 201) (:start . 188) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 72))\n ((:tag . "NN") (:stem . "lacz") (:form . "lacZ") (:end . 213) (:start . 209)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 218) (:start . 214)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s667.4) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006187@unknown@formal@none@1@S@Unexpectedly, stimulation of cloned stably transfected Jurkat T cells leads to a bimodal pattern of beta-gal expression in which some cells express no beta-gal and others express high levels.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "bimodal") (:form . "bimodal") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "beta-gal") (:form . "beta-gal") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "beta-gal") (:form . "beta-gal") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 190)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x667.5.1) (:span 148 150)))\n (:nscopes ((:id . :x667.5.1) (:span 148 159)))\n (:identifiers (:sid . :s667.5) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006188@unknown@formal@none@1@S@This expression pattern cannot be accounted for by cell-cycle position or heritable variation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "account") (:form . "accounted") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cell-cycle") (:form . "cell-cycle") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "heritable") (:form . "heritable") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x667.6.1) (:span 24 30)))\n (:nscopes ((:id . :x667.6.1) (:span 0 93)))\n (:identifiers (:sid . :s667.6) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006190@unknown@formal@none@1@S@This threshold likely reflects the NF-AT concentration-dependent assembly of transcription complexes at the promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 64) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 100)\n  (:start . 91) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 116)\n  (:start . 108) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x667.8.1) (:span 15 21)))\n (:hscopes ((:id . :x667.8.1) (:span 15 116)))\n (:identifiers (:sid . :s667.8) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006191@unknown@formal@none@1@S@Similar constructs controlled by NF-kappa B or the entire interleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of transcription factors may be a common property of inducible genes.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "bimodal") (:form . "bimodal") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 120)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 130)\n  (:start . 121) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 142)\n  (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "threshold") (:form . "thresholds") (:end . 158)\n  (:start . 148) (:id . 62))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 183) (:start . 170) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 200) (:start . 187) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 208)\n  (:start . 201) (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 212) (:start . 209)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 215) (:start . 213)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 217) (:start . 216)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 224)\n  (:start . 218) (:id . 73))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 233)\n  (:start . 225) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 246)\n  (:start . 237) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 252)\n  (:start . 247) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x667.9.1) (:span 209 212))\n  ((:id . :x667.9.2) (:span 132 142)))\n (:hscopes ((:id . :x667.9.1) (:span 209 252))\n  ((:id . :x667.9.2) (:span 132 252)))\n (:identifiers (:sid . :s667.9) (:did . :|2123468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006192@unknown@formal@none@1@S@Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 92) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "immunophilin") (:form . "immunophilin") (:end . 116)\n  (:start . 104) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s668.1) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006193@unknown@formal@none@1@S@Proliferation and immunologic function of T lymphocytes are initiated by signals from the antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin.@(((:tag . "NN") (:stem . "proliferation") (:form . "Proliferation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 150) (:start . 133) (:id . 62))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 156)\n  (:start . 151) (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 182)\n  (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "analog") (:form . "analog") (:end . 189)\n  (:start . 183) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 200)\n  (:start . 191) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x668.2.1) (:span 161 164)))\n (:nscopes ((:id . :x668.2.1) (:span 161 200)))\n (:identifiers (:sid . :s668.2) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006194@unknown@formal@none@1@S@On the other hand, interleukin 2 (IL-2)-induced signals are blocked by rapamycin but not by FK506.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2)-induced") (:form . "IL-2)-induced")\n  (:end . 47) (:start . 34) (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x668.3.1) (:span 85 88)))\n (:nscopes ((:id . :x668.3.1) (:span 85 97)))\n (:identifiers (:sid . :s668.3) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006195@unknown@formal@none@1@S@Remarkably, these two drugs inhibit each other's actions, raising the possibility that both act by means of a common immunophilin (immunosuppressant binding protein).@(((:tag . "RB") (:stem . "remarkably") (:form . "Remarkably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "raise") (:form . "raising") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "immunophilin") (:form . "immunophilin") (:end . 129)\n  (:start . 117) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 148) (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x668.4.1) (:span 58 81)))\n (:hscopes ((:id . :x668.4.1) (:span 58 165)))\n (:identifiers (:sid . :s668.4) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006196@unknown@formal@none@1@S@We find that the dissociation constant of rapamycin to the FK506 binding protein FKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to FKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 108)\n  (:start . 103) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 65))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 128)\n  (:start . 116) (:id . 66))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 146)\n  (:start . 141) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 154) (:start . 150)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Kd") (:form . "Kd") (:end . 158) (:start . 156)\n  (:id . 73))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 160) (:start . 159)\n  (:id . 74))\n ((:tag . "CD") (:stem . "0.4") (:form . "0.4") (:end . 164) (:start . 161)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 167) (:start . 165)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 79))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 181)\n  (:start . 176) (:id . 80))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 191)\n  (:start . 182) (:id . 81))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 200)\n  (:start . 192) (:id . 82))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 211)\n  (:start . 201) (:id . 83))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 226) (:start . 212) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s668.5) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006197@unknown@formal@none@1@S@However, an excess of rapamycin is needed to revert FK506-mediated inhibition of IL-2 production, apoptosis, and transcriptional activation of NF-AT, a T-cell-specific transcription factor necessary for IL-2 gene activation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "excess") (:form . "excess") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 41) (:start . 35)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "revert") (:form . "revert") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "fk506-mediated") (:form . "FK506-mediated")\n  (:end . 66) (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 128) (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 167) (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 181) (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 198)\n  (:start . 189) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 202) (:start . 199)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 212) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 223)\n  (:start . 213) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s668.6) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006198@unknown@formal@none@1@S@Similarly, an excess of FK506 is needed to revert rapamycin-mediated inhibition of IL-2-induced proliferation.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "excess") (:form . "excess") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 39) (:start . 33)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VB") (:stem . "revert") (:form . "revert") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "JJ") (:stem . "rapamycin-mediated") (:form . "rapamycin-mediated")\n  (:end . 68) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 95)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 109) (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s668.7) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006200@unknown@formal@none@1@S@FKBP has been shown to catalyze the interconversion of the cis- and trans-rotamers of the peptidyl-prolyl amide bond of peptide substrates; here we show that rapamycin, like FK506, is a potent inhibitor of the rotamase activity of FKBP (Ki = 0.2 nM).@(((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "catalyze") (:form . "catalyze") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interconversion") (:form . "interconversion")\n  (:end . 51) (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cis-") (:form . "cis-") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "trans-rotamer") (:form . "trans-rotamers")\n  (:end . 82) (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peptidyl-prolyl") (:form . "peptidyl-prolyl")\n  (:end . 105) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "amide") (:form . "amide") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "bond") (:form . "bond") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 179)\n  (:start . 174) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 192)\n  (:start . 186) (:id . 75))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 202)\n  (:start . 193) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "NN") (:stem . "rotamase") (:form . "rotamase") (:end . 218)\n  (:start . 210) (:id . 79))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 227)\n  (:start . 219) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 235) (:start . 231)\n  (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Ki") (:form . "Ki") (:end . 239) (:start . 237)\n  (:id . 84))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 241) (:start . 240)\n  (:id . 85))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 245) (:start . 242)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 248) (:start . 246)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 249) (:start . 248)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s668.9) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006201@unknown@formal@none@1@S@Neither FKBP binding nor inhibition of rotamase activity of FKBP alone is sufficient to explain the biologic actions of these drugs.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rotamase") (:form . "rotamase") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FKBP") (:form . "FKBP") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x668.10.1) (:span 0 7 21 24)))\n (:nscopes ((:id . :x668.10.1) (:span 0 131)))\n (:identifiers (:sid . :s668.10) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006202@unknown@formal@none@1@S@Rather, these findings suggest that immunophilin bound to FK506 interferes with antigen receptor-induced signals, while rapamycin bound to the immunophilin interferes with IL-2-induced signals.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunophilin") (:form . "immunophilin") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "receptor-induced") (:form . "receptor-induced")\n  (:end . 104) (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "immunophilin") (:form . "immunophilin") (:end . 155)\n  (:start . 143) (:id . 63))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 166)\n  (:start . 156) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 184)\n  (:start . 172) (:id . 66))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 192)\n  (:start . 185) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x668.11.1) (:span 23 30)))\n (:hscopes ((:id . :x668.11.1) (:span 23 192)))\n (:identifiers (:sid . :s668.11) (:did . :|2123553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006203@unknown@formal@none@1@S@Transcriptional down-regulation of c-myc expression by protein synthesis-dependent and -independent pathways in a human T lymphoblastic tumor cell line.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 31) (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 40) (:start . 35)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "JJ") (:stem . "synthesis-dependent")\n  (:form . "synthesis-dependent") (:end . 82) (:start . 63) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 99)\n  (:start . 87) (:id . 51))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 108)\n  (:start . 100) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 135) (:start . 122) (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 141)\n  (:start . 136) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 151) (:start . 147)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s669.1) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006204@unknown@formal@none@1@S@We show that in the human T lymphoblastic tumor cell line Molt4 c-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide, to phorbol myristate acetate, or to the calcium ionophore A23187, which raises the intracellular calcium concentration.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 41) (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "molt4") (:form . "Molt4") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 115) (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dimethyl") (:form . "dimethyl") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "sulfoxide") (:form . "sulfoxide") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 174)\n  (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 182)\n  (:start . 175) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 186) (:start . 184)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 201)\n  (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . "NN") (:stem . "a23187") (:form . "A23187") (:end . 218)\n  (:start . 212) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 225)\n  (:start . 220) (:id . 79))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 232)\n  (:start . 226) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 236) (:start . 233)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 250) (:start . 237) (:id . 82))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 258)\n  (:start . 251) (:id . 83))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 272) (:start . 259) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s669.2) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006205@unknown@formal@none@1@S@A block to RNA elongation is largely responsible for decreased c-myc transcription.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 25)\n  (:start . 15) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s669.3) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006206@unknown@formal@none@1@S@Although negative regulation by dimethyl sulfoxide takes place even when protein synthesis is inhibited by cycloheximide, the phorbol myristate acetate effect is blocked to some extent only by cycloheximide.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dimethyl") (:form . "dimethyl") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "sulfoxide") (:form . "sulfoxide") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 120) (:start . 107) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 184)\n  (:start . 178) (:id . 68))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 189) (:start . 185)\n  (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 206) (:start . 193) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s669.4) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006207@unknown@formal@none@1@S@The calcium ionophore-induced c-myc suppression, however, strictly requires de novo protein synthesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "ionophore-induced") (:form . "ionophore-induced")\n  (:end . 29) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s669.5) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006208@unknown@formal@none@1@S@Therefore, two different negative regulatory pathways are involved in c-myc regulation: one which is independent and one which depends on de novo protein synthesis.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 153)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s669.6) (:did . :|2127692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006210@unknown@formal@none@1@S@Induction of immediate early response genes by macrophage colony-stimulating factor in normal human monocytes.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 76) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 83)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s670.1) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006211@unknown@formal@none@1@S@A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes have been termed immediate early response genes, and their induction has been associated with growth factor-stimulated cell proliferation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "protooncogene") (:form . "protooncogenes")\n  (:end . 46) (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cytoskeletal") (:form . "cytoskeletal") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 109)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 181)\n  (:start . 171) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 186) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 193)\n  (:start . 187) (:id . 70))\n ((:tag . "JJ") (:stem . "factor-stimulated") (:form . "factor-stimulated")\n  (:end . 211) (:start . 194) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 72))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 230) (:start . 217) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s670.2) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006212@unknown@formal@none@1@S@We have investigated the induction of these genes by macrophage-CSF (M-CSF) in human monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "macrophage-CSF") (:form . "macrophage-CSF")\n  (:end . 67) (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "VB") (:stem . "proliferate") (:form . "proliferate") (:end . 118)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 174)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 195) (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x670.3.1) (:span 103 106)))\n (:nscopes ((:id . :x670.3.1) (:span 103 139)))\n (:identifiers (:sid . :s670.3) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006213@unknown@formal@none@1@S@Normal human monocytes were isolated, carefully washed, and incubated for 36 to 48 h in fetal bovine serum-containing medium.@(((:tag . "JJ") (:stem . "normal") (:form . "Normal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "carefully") (:form . "carefully") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "wash") (:form . "washed") (:end . 54) (:start . 48)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "JJ") (:stem . "serum-containing") (:form . "serum-containing")\n  (:end . 117) (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s670.4) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006214@unknown@formal@none@1@S@At the end of this incubation the resting cells were stimulated with M-CSF, and RNA was isolated for analysis by Northern blotting.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 29)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s670.5) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006215@unknown@formal@none@1@S@RNA from control resting cells contained low to undetectable levels of c-jun, fibronectin receptor, and actin mRNA.@(((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "actin") (:form . "actin") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s670.6) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006216@unknown@formal@none@1@S@Within 15 to 30 min of addition of M-CSF, however, there was a dramatic coordinate induction of these genes.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 49)\n  (:start . 42) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 53))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 56) (:start . 51)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 71)\n  (:start . 63) (:id . 57))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 82)\n  (:start . 72) (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 92)\n  (:start . 83) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 101) (:start . 96)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 107)\n  (:start . 102) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s670.7) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006217@unknown@formal@none@1@S@The c-jun gene expression was very transient and was not detectable by 60 min after M-CSF addition.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x670.8.1) (:span 53 56)))\n (:nscopes ((:id . :x670.8.1) (:span 53 98)))\n (:identifiers (:sid . :s670.8) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006218@unknown@formal@none@1@S@In contrast, the expression of actin and fibronectin receptor mRNA was more sustained, and the expression of these genes remained elevated at 24 to 48 h after M-CSF addition.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "actin") (:form . "actin") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "sustain") (:form . "sustained") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 158)\n  (:start . 153) (:id . 70))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 164)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 173)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s670.9) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006220@unknown@formal@none@1@S@The protein synthesis inhibitor cycloheximide did not block the induction of any of these genes, and in fact, super-induced the expression of c-jun and hck.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 45) (:start . 32) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "super-induced") (:form . "super-induced")\n  (:end . 123) (:start . 110) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "hck") (:form . "hck") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x670.11.1) (:span 50 53)))\n (:nscopes ((:id . :x670.11.1) (:span 50 95)))\n (:identifiers (:sid . :s670.11) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006221@unknown@formal@none@1@S@Nuclear run on transcription of the c-jun, hck, and actin genes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "run") (:form . "run") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hck") (:form . "hck") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "actin") (:form . "actin") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s670.12) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006222@unknown@formal@none@1@S@Therefore, in normal human monocytes M-CSF induces immediate early response genes without inducing cell proliferation.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 117) (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x670.13.1) (:span 82 89)))\n (:nscopes ((:id . :x670.13.1) (:span 82 117)))\n (:identifiers (:sid . :s670.13) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006223@unknown@formal@none@1@S@These genes may then play a role in altering the physiologic status of the cells in response to CSF.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 60)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CSF") (:form . "CSF") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x670.14.1) (:span 12 15)))\n (:hscopes ((:id . :x670.14.1) (:span 12 99)))\n (:identifiers (:sid . :s670.14) (:did . :|2144551|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006224@unknown@formal@none@1@S@Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 138) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "enhancer-dependent") (:form . "enhancer-dependent")\n  (:end . 165) (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x671.1.1) (:span 112 115)))\n (:nscopes ((:id . :x671.1.1) (:span 112 179)))\n (:identifiers (:sid . :s671.1) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006225@unknown@formal@none@1@S@The expression of transiently transfected expression vectors under the control of the long terminal repeat (LTR) of the human immunodeficiency virus (HIV) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . 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"necrosis") (:end . 359)\n  (:start . 351) (:id . 98))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 366)\n  (:start . 360) (:id . 99))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 369) (:start . 367)\n  (:id . 100))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 377)\n  (:start . 370) (:id . 101))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 390)\n  (:start . 378) (:id . 102))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 401)\n  (:start . 391) (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 402) (:start . 401)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s671.2) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006226@unknown@formal@none@1@S@We found a dissociation of NF-kappa B translocation from transactivation of either the HIV LTR or the HIV enhancer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s671.3) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006227@unknown@formal@none@1@S@Interleukin 2 induced proliferation but not NF-kappa B translocation or LTR transactivation.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 91) (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x671.4.1) (:span 40 43)))\n (:nscopes ((:id . :x671.4.1) (:span 40 91)))\n (:identifiers (:sid . :s671.4) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006228@unknown@formal@none@1@S@Phorbol ester or specific antigen recognition induced HIV LTR transactivation, whereas stimulation with tumor necrosis factor or antibody to CD3 did not.@(((:tag . "NNP") (:stem . "Phorbol") (:form . "Phorbol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 77) (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 125)\n  (:start . 119) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x671.5.1) (:span 149 152)))\n (:nscopes ((:id . :x671.5.1) (:span 149 152)))\n (:identifiers (:sid . :s671.5) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006230@unknown@formal@none@1@S@Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer-dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . 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"in") (:end . 306) (:start . 304)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 312)\n  (:start . 307) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 315) (:start . 313)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 328)\n  (:start . 316) (:id . 92))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 332) (:start . 329)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 336) (:start . 333)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 340) (:start . 337)\n  (:id . 95))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 351)\n  (:start . 341) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 352) (:start . 351)\n  (:id . 97)))@@@1@56@((:hcues ((:id . :x671.7.1) (:span 240 254)))\n (:ncues ((:id . :x671.7.2) (:span 88 91)))\n (:hscopes ((:id . :x671.7.1) (:span 240 351)))\n (:nscopes ((:id . :x671.7.2) (:span 88 167)))\n (:identifiers (:sid . :s671.7) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006231@unknown@formal@none@1@S@Furthermore, our results suggest that events linked to T-cell activation, in addition to NF-kappa B translocation per se, induce functional interactions of the NF-kappa B complex with the HIV enhancer.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 51) (:start . 45)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 113) (:start . 100) (:id . 59))\n ((:tag . "FW") (:stem . "per") (:form . "per") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "FW") (:stem . "se") (:form . "se") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 152)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 178)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 191) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 200)\n  (:start . 192) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x671.8.1) (:span 25 32)))\n (:hscopes ((:id . :x671.8.1) (:span 25 200)))\n (:identifiers (:sid . :s671.8) (:did . :|2146676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006232@unknown@formal@none@1@S@Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 61)\n  (:start . 51) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 76)\n  (:start . 67) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phop") (:form . "phoP") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virulence") (:form . "virulence") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 106)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Salmonella") (:form . "Salmonella") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "NNP") (:stem . "typhimurium") (:form . "typhimurium") (:end . 132)\n  (:start . 121) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s672.1) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006233@unknown@formal@none@1@S@The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "sensitivity") (:form . "sensitivities") (:end . 26)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Salmonella") (:form . "Salmonella") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "typhimurium") (:form . "typhimurium") (:end . 52)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phop/phoq") (:form . "phoP/phoQ") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "two-component") (:form . "two-component")\n  (:end . 106) (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "virulence") (:form . "virulence") (:end . 116)\n  (:start . 107) (:id . 55))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 124)\n  (:start . 117) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 129) (:start . 125)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 136)\n  (:start . 130) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 145) (:start . 140)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "NNS") (:stem . "defensin") (:form . "defensins") (:end . 164)\n  (:start . 155) (:id . 62))\n ((:tag . "NN") (:stem . "np-1") (:form . "NP-1") (:end . 169) (:start . 165)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 64))\n ((:tag . "NN") (:stem . "np-2") (:form . "NP-2") (:end . 178) (:start . 174)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s672.2) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006234@unknown@formal@none@1@S@Strains with mutations in either gene of the regulatory pair (phoP [transcriptional activator] or phoQ [membrane sensor kinase]) had increased sensitivities to defensin.@(((:tag . "NNS") (:stem . "strain") (:form . "Strains") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phop") (:form . "phoP") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 83) (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phoq") (:form . "phoQ") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "sensor") (:form . "sensor") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 142)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "sensitivity") (:form . "sensitivities")\n  (:end . 156) (:start . 143) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s672.3) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006235@unknown@formal@none@1@S@The predicted periplasmic domain of the PhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "periplasmic") (:form . "periplasmic") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PhoQ") (:form . "PhoQ") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "anionic") (:form . "anionic") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cationic") (:form . "cationic") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 161)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 176)\n  (:start . 166) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 188)\n  (:start . 180) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x672.4.1) (:span 141 146))\n  ((:id . :x672.4.2) (:span 94 99)))\n (:hscopes ((:id . :x672.4.1) (:span 141 188))\n  ((:id . :x672.4.2) (:span 94 131)))\n (:identifiers (:sid . :s672.4) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006236@unknown@formal@none@1@S@Because insertion mutations in phoP are polar on phoQ, we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phop") (:form . "phoP") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "polar") (:form . "polar") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "phoQ") (:form . "phoQ") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "construct") (:form . "constructed") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PhoQ") (:form . "PhoQ") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PhoP") (:form . "PhoP") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 148)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 159)\n  (:start . 149) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 180)\n  (:start . 172) (:id . 71))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "phoq") (:form . "phoQ") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 199) (:start . 195)\n  (:id . 75))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 207)\n  (:start . 200) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x672.5.1) (:span 141 148)))\n (:ncues ((:id . :x672.5.2) (:span 117 124)))\n (:hscopes ((:id . :x672.5.1) (:span 141 207)))\n (:nscopes ((:id . :x672.5.2) (:span 117 132)))\n (:identifiers (:sid . :s672.5) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006237@unknown@formal@none@1@S@We found that resistance to defensin requires the function of both components of this regulatory system, because strains expressing PhoQ without PhoP were still markedly sensitive to defensins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "NNP") (:stem . "PhoQ") (:form . "PhoQ") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "PhoP") (:form . "PhoP") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 169)\n  (:start . 161) (:id . 67))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 179)\n  (:start . 170) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "defensin") (:form . "defensins") (:end . 192)\n  (:start . 183) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x672.6.1) (:span 137 144)))\n (:nscopes ((:id . :x672.6.1) (:span 137 149)))\n (:identifiers (:sid . :s672.6) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006238@unknown@formal@none@1@S@This implied that a pag (phoP-activated gene) product is responsible for defensin resistance.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "imply") (:form . "implied") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pag") (:form . "pag") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "phop-activated") (:form . "phoP-activated")\n  (:end . 39) (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x672.7.1) (:span 5 12)))\n (:hscopes ((:id . :x672.7.1) (:span 5 92)))\n (:identifiers (:sid . :s672.7) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006240@unknown@formal@none@1@S@Defensin resistance is not the only virulence characteristic controlled by the PhoP-PhoQ regulon because mutations in pagC, as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc), had no effect on defensin resistance, even though they rendered the organism avirulent and deficient in survival within macrophages.@(((:tag . "NNP") (:stem . "Defensin") (:form . "Defensin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "virulence") (:form . "virulence") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 60) (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PhoP-PhoQ") (:form . "PhoP-PhoQ") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pagc") (:form . 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"result") (:form . "resulted") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 187)\n  (:start . 175) (:id . 71))\n ((:tag . "NN") (:stem . "pag") (:form . "pag") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 202)\n  (:start . 192) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 204) (:start . 203)\n  (:id . 74))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 213)\n  (:start . 204) (:id . 75))\n ((:tag . "NNP") (:stem . "PhoPc") (:form . "PhoPc") (:end . 219)\n  (:start . 214) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 225) (:start . 222)\n  (:id . 79))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 228) (:start . 226)\n  (:id . 80))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 235)\n  (:start . 229) (:id . 81))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 238) (:start . 236)\n  (:id . 82))\n ((:tag . "NN") (:stem . "defensin") (:form . "defensin") (:end . 247)\n  (:start . 239) (:id . 83))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 258)\n  (:start . 248) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 259) (:start . 258)\n  (:id . 85))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 264) (:start . 260)\n  (:id . 86))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 271)\n  (:start . 265) (:id . 87))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 276) (:start . 272)\n  (:id . 88))\n ((:tag . "VBD") (:stem . "render") (:form . 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5006241@unknown@formal@none@1@S@The virulence defect conferred by mutations in the phoP-phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "virulence") (:form . "virulence") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "confer") (:form . "conferred") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phop-phoq") (:form . "phoP-phoQ") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "two-component") (:form . "two-component")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 135)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 149)\n  (:start . 139) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cationic") (:form . "cationic") (:end . 161)\n  (:start . 153) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 170)\n  (:start . 162) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 183)\n  (:start . 175) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 67))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 195)\n  (:start . 188) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 204)\n  (:start . 199) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 213)\n  (:start . 205) (:id . 71))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 223)\n  (:start . 214) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 227) (:start . 224)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 230) (:start . 228)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "typhimurium") (:form . "typhimurium") (:end . 242)\n  (:start . 231) (:id . 75))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 251)\n  (:start . 243) (:id . 76))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 258)\n  (:start . 252) (:id . 77))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 270)\n  (:start . 259) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s672.10) (:did . :|2172166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5006243@unknown@formal@none@1@S@Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "amp-dependent") (:form . "AMP-dependent")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 107) (:start . 94) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-1)-responsive") (:form . "IL-1)-responsive")\n  (:end . 125) (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 58))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 139)\n  (:start . 132) (:id . 59))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 152)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 171) (:start . 158) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 176) (:start . 172)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 180) (:start . 177)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 187)\n  (:start . 181) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 190) (:start . 188)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 200)\n  (:start . 195) (:id . 68))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 215) (:start . 201) (:id . 69))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 224)\n  (:start . 216) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 227) (:start . 225)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 237)\n  (:start . 232) (:id . 73))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 254) (:start . 238) (:id . 74))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 260)\n  (:start . 255) (:id . 75))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 265) (:start . 261)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 274)\n  (:start . 266) (:id . 77))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 281)\n  (:start . 275) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s673.2) (:did . :|2192264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5006245@unknown@formal@none@1@S@Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "monocyte/macrophage-specific")\n  (:form . "monocyte/macrophage-specific") (:end . 59) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulator") (:form . "stimulator") (:end . 70)\n  (:start . 60) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 96) (:start . 80) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 102) (:start . 97)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 107) (:start . 103)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 109) (:start . 108)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s674.1) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006246@unknown@formal@none@1@S@Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 67) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "1-long") (:form . "1-long") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 101)\n  (:start . 95) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1-LTR") (:form . "HIV-1-LTR") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 140)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "monocyte/macrophage-like")\n  (:form . "monocyte/macrophage-like") (:end . 170) (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 175) (:start . 171)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 181)\n  (:start . 176) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 185) (:start . 182)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 189) (:start . 186)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 191) (:start . 190)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 198) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 203) (:start . 199)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x674.2.1) (:span 186 189)))\n (:nscopes ((:id . :x674.2.1) (:span 186 203)))\n (:identifiers (:sid . :s674.2) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006247@unknown@formal@none@1@S@This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x674.3.1) (:span 12 19)))\n (:hscopes ((:id . :x674.3.1) (:span 0 95)))\n (:identifiers (:sid . :s674.3) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006248@unknown@formal@none@1@S@Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 49)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 107) (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 121)\n  (:start . 113) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s674.4) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006250@unknown@formal@none@1@S@The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "granulocyte/macrophage")\n  (:form . "granulocyte/macrophage") (:end . 122) (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 141) (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 64))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 164)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 174)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s674.6) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006251@unknown@formal@none@1@S@This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s674.7) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006252@unknown@formal@none@1@S@LPS is not able to induce HIV-1 production in a cloned T cell line.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x674.8.1) (:span 7 10)))\n (:nscopes ((:id . :x674.8.1) (:span 7 66)))\n (:identifiers (:sid . :s674.8) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006253@unknown@formal@none@1@S@The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "picogram") (:form . "picogram") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "milliliter") (:form . "milliliter") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 87) (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "understand") (:form . "understanding") (:end . 138)\n  (:start . 125) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "variability") (:form . "variability") (:end . 154)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "history") (:form . "history") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 186)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 196)\n  (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x674.9.1) (:span 92 95)))\n (:hscopes ((:id . :x674.9.1) (:span 92 196)))\n (:identifiers (:sid . :s674.9) (:did . :|2193097|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006254@unknown@formal@none@1@S@Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner.@(((:tag . "JJ") (:stem . "inducible") (:form . "Inducible") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 86) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 142)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "signal-dependent") (:form . "signal-dependent")\n  (:end . 166) (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 173)\n  (:start . 167) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s675.1) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006255@unknown@formal@none@1@S@Cyclosporin A (CsA) is thought to exert its immunosuppressive effects by inhibiting the expression of a distinct set of lymphokine genes which are induced upon T-cell activation, among them the gene coding for interleukin-2.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 61) (:start . 44) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 130)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 177)\n  (:start . 167) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 189) (:start . 185)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 198) (:start . 194)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 205)\n  (:start . 199) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 209) (:start . 206)\n  (:id . 77))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 223) (:start . 210) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x675.2.1) (:span 23 30)))\n (:hscopes ((:id . :x675.2.1) (:span 0 223)))\n (:identifiers (:sid . :s675.2) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006256@unknown@formal@none@1@S@In addition, the activation of the human immunodeficiency virus (HIV) is partially suppressed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 57) (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s675.3) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006257@unknown@formal@none@1@S@To better understand the molecular mechanisms underlying suppression by CsA, we have investigated the effects of this drug on transcription factors in T cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 68)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 97)\n  (:start . 85) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s675.4) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006258@unknown@formal@none@1@S@Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes, the kappa B complex within the HIV enhancer and the NFAT-1 complex within the interleukin-2 enhancer, is inhibited in the presence of CsA.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "mitogen-inducible") (:form . "mitogen-inducible")\n  (:end . 67) (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 182) (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 191)\n  (:start . 183) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 205)\n  (:start . 196) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 75))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 221)\n  (:start . 213) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 228) (:start . 225)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s675.5) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006260@unknown@formal@none@1@S@This suggests a model in which functionally indistinguishable kappa B complexes can be activated via two separate pathways of signal transduction distinguishable by CsA.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 61) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 145)\n  (:start . 133) (:id . 62))\n ((:tag . "JJ") (:stem . "distinguishable") (:form . "distinguishable")\n  (:end . 161) (:start . 146) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x675.7.1) (:span 5 13)))\n (:hscopes ((:id . :x675.7.1) (:span 5 168)))\n (:identifiers (:sid . :s675.7) (:did . :|2196387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006261@unknown@formal@none@1@S@Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor.@(((:tag . "JJ") (:stem . "cell-specific") (:form . "Cell-specific")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 99) (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 125)\n  (:start . 115) (:id . 57))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 144)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 153)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 160)\n  (:start . 154) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s676.1) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006262@unknown@formal@none@1@S@Three aspects of the involvement of tumor necrosis factor in human immunodeficiency virus (HIV) pathogenesis were examined.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 83) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 108)\n  (:start . 96) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s676.2) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006263@unknown@formal@none@1@S@Tumor necrosis factor alpha (TNF-alpha) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line (U9-IIIB).@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "amplification") (:form . "amplification")\n  (:end . 111) (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 156)\n  (:start . 145) (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 169)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "U9-IIIB") (:form . "U9-IIIB") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s676.3) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006264@unknown@formal@none@1@S@TNF-alpha RNA was undetectable in U937 cells, whereas a low constitutive level was detected in U9-IIIB cells.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "U9-IIIB") (:form . "U9-IIIB") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s676.4) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006265@unknown@formal@none@1@S@Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells, suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection.@(((:tag . "NNP") (:stem . "Paramyxovirus") (:form . "Paramyxovirus")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "CD") (:stem . "5-") (:form . "5-") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "10-fold") (:form . "10-fold") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 76)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "U9-IIIB") (:form . "U9-IIIB") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 171)\n  (:start . 159) (:id . 67))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 203)\n  (:start . 197) (:id . 71))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 210)\n  (:start . 204) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 223)\n  (:start . 214) (:id . 74))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 228) (:start . 224)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 232) (:start . 229)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 239)\n  (:start . 233) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 245)\n  (:start . 240) (:id . 78))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 251)\n  (:start . 246) (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 253) (:start . 252)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 263)\n  (:start . 254) (:id . 81))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 269)\n  (:start . 264) (:id . 82))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 279)\n  (:start . 270) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x676.5.1) (:span 143 153)))\n (:hscopes ((:id . :x676.5.1) (:span 143 279)))\n (:identifiers (:sid . :s676.5) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006266@unknown@formal@none@1@S@The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat (LTR) and the beta interferon promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 119) (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 137) (:start . 120) (:id . 58))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 146)\n  (:start . 138) (:id . 59))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 153)\n  (:start . 147) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 167)\n  (:start . 157) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 176)\n  (:start . 168) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 181) (:start . 177)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 189) (:start . 186)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 194) (:start . 190)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 203)\n  (:start . 195) (:id . 68))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 210)\n  (:start . 204) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 212) (:start . 211)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 215) (:start . 212)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 74))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 229) (:start . 225)\n  (:id . 75))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 240)\n  (:start . 230) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 249)\n  (:start . 241) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s676.6) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006267@unknown@formal@none@1@S@In U937 and Jurkat T lymphoid cells, the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B-containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . 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5006268@unknown@formal@none@1@S@Although the intact beta interferon promoter was only weakly stimulated by phorbol ester or TNF-alpha, multimers of the PRDII NF-kappa B-binding domain were inducible by both agents.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "multimer") (:form . "multimers") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PRDII") (:form . "PRDII") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 151)\n  (:start . 145) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 166)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 181)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s676.8) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006270@unknown@formal@none@1@S@This level of NF-kappa B-independent activity appears to be sufficient for virus multiplication, since TNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 (HIV-1) infection and viral RNA production in U937 cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "b-independent") (:form . "B-independent")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "multiplication") (:form . "multiplication")\n  (:end . 95) (:start . 81) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 181)\n  (:start . 176) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 192)\n  (:start . 183) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 202)\n  (:start . 197) (:id . 76))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 206) (:start . 203)\n  (:id . 77))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 217)\n  (:start . 207) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 79))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 231)\n  (:start . 226) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x676.10.2) (:span 46 53)))\n (:ncues ((:id . :x676.10.1) (:span 127 129)))\n (:hscopes ((:id . :x676.10.2) (:span 0 95)))\n (:nscopes ((:id . :x676.10.1) (:span 127 231)))\n (:identifiers (:sid . :s676.10) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006271@unknown@formal@none@1@S@However, in Jurkat cells, TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis, indicating that in T cells HIV-1 multiplication was stimulated by TNF-alpha treatment.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 48)\n  (:start . 36) (:id . 49))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "spread") (:form . "spread") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 151)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 69))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "NN") (:stem . "multiplication") (:form . "multiplication")\n  (:end . 188) (:start . 174) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 203)\n  (:start . 193) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 216)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 226)\n  (:start . 217) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x676.11.1) (:span 141 156)))\n (:hscopes ((:id . :x676.11.1) (:span 141 226)))\n (:identifiers (:sid . :s676.11) (:did . :|2204723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006272@unknown@formal@none@1@S@Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.@(((:tag . "NNP") (:stem . "Astrocyte") (:form . "Astrocytes") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "glioblastoma") (:form . "glioblastoma") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "octamer-dna") (:form . "octamer-DNA") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 85)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 111)\n  (:start . 106) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s677.1) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006273@unknown@formal@none@1@S@The 'octamer' sequence, ATGCAAAT or its complement ATTTGCAT, is a key element for the transcriptional regulation of immunoglobulin genes in B-lymphocytes as well as a number of housekeeping genes in all cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "'octamer") (:form . "'octamer") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ATGCAAAT") (:form . "ATGCAAAT") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "NNP") (:stem . "ATTTGCAT") (:form . "ATTTGCAT") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 130) (:start . 116) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "b-lymphocyte") (:form . "B-lymphocytes")\n  (:end . 153) (:start . 140) (:id . 65))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 173)\n  (:start . 167) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "housekeeping") (:form . "housekeeping") (:end . 189)\n  (:start . 177) (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 195)\n  (:start . 190) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 202) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 207) (:start . 203)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 213)\n  (:start . 208) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s677.2) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006274@unknown@formal@none@1@S@In lymphocytes, the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression, while the ubiquitous protein Oct-1 seems to control general octamer site-dependent transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 35) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "RB") (:stem . "thereof") (:form . "thereof") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 189)\n  (:start . 182) (:id . 70))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 197)\n  (:start . 190) (:id . 71))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 205)\n  (:start . 198) (:id . 72))\n ((:tag . "JJ") (:stem . "site-dependent") (:form . "site-dependent")\n  (:end . 220) (:start . 206) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 234) (:start . 221) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x677.3.1) (:span 173 178))\n  ((:id . :x677.3.2) (:span 76 83)))\n (:hscopes ((:id . :x677.3.1) (:span 144 234))\n  ((:id . :x677.3.2) (:span 16 136)))\n (:identifiers (:sid . :s677.3) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006275@unknown@formal@none@1@S@Various other genes, for example interleukin-1 and MHC class II genes, contain an octamer sequence in the promoter and are expressed in cells of both the immune and nervous systems.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 160)\n  (:start . 154) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 172)\n  (:start . 165) (:id . 72))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 180)\n  (:start . 173) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s677.4) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006276@unknown@formal@none@1@S@This prompted us to analyze the octamer-binding proteins in the latter cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "prompt") (:form . "prompted") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 47) (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s677.5) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006277@unknown@formal@none@1@S@Using the electrophoretic mobility shift assay, at least six novel octamer binding proteins were detected in nuclear extracts of cultured mouse astrocytes.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s677.6) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006278@unknown@formal@none@1@S@These proteins are differentially expressed in human glioblastoma and neuroblastoma cell lines.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 33) (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "glioblastoma") (:form . "glioblastoma") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s677.7) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006280@unknown@formal@none@1@S@The relationship of the N-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and Oct-2A proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "N-Oct") (:form . "N-Oct") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "clipping") (:form . "clipping") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "bandshift") (:form . "bandshift") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "reactivity") (:form . "reactivity") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "antiserum") (:form . "antisera") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 168)\n  (:start . 161) (:id . 66))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 180)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 186)\n  (:start . 181) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 197)\n  (:start . 191) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 206)\n  (:start . 198) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s677.9) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006281@unknown@formal@none@1@S@On the basis of these assays, all N-Oct-factors were found to be distinct from the ubiquitous Oct-1 and the lymphoid-specific Oct-2A proteins.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "n-oct-factor") (:form . "N-Oct-factors")\n  (:end . 47) (:start . 34) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 125) (:start . 108) (:id . 62))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s677.10) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006282@unknown@formal@none@1@S@In melanoma cells that contain the N-Oct-3 factor, a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an Oct-2A expression vector.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "melanoma") (:form . "melanoma") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "n-oct-3") (:form . "N-Oct-3") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 84) (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "repress") (:form . "repressed") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "contransfection") (:form . "contransfection")\n  (:end . 157) (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 172)\n  (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 190)\n  (:start . 184) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x677.11.1) (:span 98 105 116 119)))\n (:nscopes ((:id . :x677.11.1) (:span 51 190)))\n (:identifiers (:sid . :s677.11) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006283@unknown@formal@none@1@S@We therefore speculate that N-Oct-3 and other N-Oct factors have a specific role in gene expression in cells of the nervous system.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "speculate") (:form . "speculate") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "n-oct-3") (:form . "N-Oct-3") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "N-Oct") (:form . "N-Oct") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x677.12.1) (:span 13 22)))\n (:hscopes ((:id . :x677.12.1) (:span 13 130)))\n (:identifiers (:sid . :s677.12) (:did . :|2216722|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006284@unknown@formal@none@1@S@Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.@(((:tag . "NN") (:stem . "cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mitogen-inducible") (:form . "mitogen-inducible")\n  (:end . 30) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cell-cycle") (:form . "cell-cycle") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s678.1) (:did . :|2234062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006285@unknown@formal@none@1@S@We have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts a protein of 968 amino acids.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mitogen-inducible") (:form . "mitogen-inducible")\n  (:end . 52) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "CD") (:stem . "968") (:form . "968") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s678.2) (:did . :|2234062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006286@unknown@formal@none@1@S@The amino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene dorsal of Drosophila.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 95) (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dorsal") (:form . "dorsal") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s678.3) (:did . :|2234062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006287@unknown@formal@none@1@S@The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans, as well as in the putative human oncogene bcl-3 and in the ankyrin protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 54)\n  (:start . 44) (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 60) (:start . 55)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell-cycle") (:form . "cell-cycle") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 164) (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 178)\n  (:start . 168) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Ceanorhabditis") (:form . "Ceanorhabditis")\n  (:end . 197) (:start . 183) (:id . 69))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 205)\n  (:start . 198) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 206) (:start . 205)\n  (:id . 71))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 214) (:start . 210)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 233)\n  (:start . 225) (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 239)\n  (:start . 234) (:id . 78))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 248)\n  (:start . 240) (:id . 79))\n ((:tag . "NN") (:stem . "bcl-3") (:form . "bcl-3") (:end . 254)\n  (:start . 249) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 258) (:start . 255)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 261) (:start . 259)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 265) (:start . 262)\n  (:id . 83))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 273)\n  (:start . 266) (:id . 84))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 281)\n  (:start . 274) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s678.4) (:did . :|2234062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006288@unknown@formal@none@1@S@A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the kappa B binding site found in many inducible genes, including the enhancer in human immunodeficiency virus.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 81)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 118)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 172)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 202)\n  (:start . 194) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 211)\n  (:start . 206) (:id . 77))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 228) (:start . 212) (:id . 78))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 234)\n  (:start . 229) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s678.5) (:did . :|2234062|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006290@unknown@formal@none@1@S@Regulation of gene expression with double-stranded phosphorothioate oligonucleotides.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 67) (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 84) (:start . 68) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s679.1) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006291@unknown@formal@none@1@S@Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how these factors participate in cellular differentiation.@(((:tag . "NNP") (:stem . "Alteration") (:form . "Alteration") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 74) (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 85)\n  (:start . 75) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 107)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 123)\n  (:start . 112) (:id . 56))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 127) (:start . 124)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 133)\n  (:start . 128) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 153)\n  (:start . 142) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 165)\n  (:start . 157) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 181) (:start . 166) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s679.2) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006292@unknown@formal@none@1@S@The functions of these proteins can be antagonized by several methods, each with specific limitations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "antagonize") (:form . "antagonized") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "limitation") (:form . "limitations") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s679.3) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006293@unknown@formal@none@1@S@Inhibition of sequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 31) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 43)\n  (:start . 32) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 52)\n  (:start . 44) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 86) (:start . 71) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "d") (:form . "ds") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 108) (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 125) (:start . 109) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 140)\n  (:start . 131) (:id . 57))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 148)\n  (:start . 141) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 151) (:start . 149)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 157)\n  (:start . 152) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 61))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 169)\n  (:start . 160) (:id . 62))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 179)\n  (:start . 170) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s679.4) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006294@unknown@formal@none@1@S@The phosphorothioate oligonucleotides specifically bound either octamer transcription factor or nuclear factor (NF)-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 37) (:start . 21) (:id . 44))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 50)\n  (:start . 38) (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 56) (:start . 51)\n  (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 63)\n  (:start . 57) (:id . 47))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 71)\n  (:start . 64) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 92)\n  (:start . 86) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 103)\n  (:start . 96) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 121)\n  (:start . 112) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s679.5) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006295@unknown@formal@none@1@S@The modified oligonucleotides accumulated in cells more effectively than standard ds oligonucleotides and modulated gene expression in a specific manner.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "modified") (:form . "modified") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 29) (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "accumulate") (:form . "accumulated") (:end . 41)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 67)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "d") (:form . "ds") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 101) (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 115)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 145)\n  (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 152)\n  (:start . 146) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s679.6) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006296@unknown@formal@none@1@S@Octamer-dependent activation of a reporter plasmid or NF-kappa B-dependent activation of the human immunodeficiency virus (HIV) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line.@(((:tag . "JJ") (:stem . "octamer-dependent") (:form . "Octamer-dependent")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 74)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 115) (:start . 99) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 121)\n  (:start . 116) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 136)\n  (:start . 128) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 150)\n  (:start . 141) (:id . 62))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 171)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 188) (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 204) (:start . 189) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 208) (:start . 205)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 214) (:start . 209)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 217) (:start . 215)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 219) (:start . 218)\n  (:id . 71))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 231)\n  (:start . 220) (:id . 72))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 243)\n  (:start . 232) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 245) (:start . 244)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 250) (:start . 246)\n  (:id . 75))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 255) (:start . 251)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s679.7) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006297@unknown@formal@none@1@S@Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 (IL-2) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 28) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 45) (:start . 29) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 60)\n  (:start . 51) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 48))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 72)\n  (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 82)\n  (:start . 73) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 92)\n  (:start . 86) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 55))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 119)\n  (:start . 110) (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 133) (:start . 120) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 139) (:start . 135)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 150)\n  (:start . 141) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 170)\n  (:start . 163) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 187)\n  (:start . 179) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 192) (:start . 188)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 194) (:start . 193)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 202)\n  (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 210)\n  (:start . 203) (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 215) (:start . 211)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 227) (:start . 223)\n  (:id . 76))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 236)\n  (:start . 228) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s679.8) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006298@unknown@formal@none@1@S@The ds phosphorothioate oligonucleotides probably compete for binding of specific transcription factors and may provide anti-viral, immunosuppressive, or other therapeutic effects.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "d") (:form . "ds") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 23) (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 40) (:start . 24) (:id . 45))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "VBP") (:stem . "compete") (:form . "compete") (:end . 57)\n  (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 103)\n  (:start . 96) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 119)\n  (:start . 112) (:id . 56))\n ((:tag . "JJ") (:stem . "anti-viral") (:form . "anti-viral") (:end . 130)\n  (:start . 120) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 149) (:start . 132) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 153) (:start . 151)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 159)\n  (:start . 154) (:id . 62))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 171)\n  (:start . 160) (:id . 63))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 179)\n  (:start . 172) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x679.9.1) (:span 108 111))\n  ((:id . :x679.9.2) (:span 41 49)))\n (:hscopes ((:id . :x679.9.1) (:span 108 179))\n  ((:id . :x679.9.2) (:span 41 103)))\n (:identifiers (:sid . :s679.9) (:did . :|2237444|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006300@unknown@formal@none@1@S@Response to T cell activation signals.@(((:tag . "NNP") (:stem . "Response") (:form . "Response") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s680.2) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006301@unknown@formal@none@1@S@T cell activation results in high levels of HIV replication and is thought to be one mechanism leading to the conversion from latent to active viral infection.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 142)\n  (:start . 136) (:id . 66))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x680.3.1) (:span 67 74)))\n (:hscopes ((:id . :x680.3.1) (:span 64 158)))\n (:identifiers (:sid . :s680.3) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006302@unknown@formal@none@1@S@In HIV-1, the sequences that respond to these signaling events are found in the long terminal repeat (LTR) and comprise the transcriptional enhancer, which contains two conserved binding sites for the nuclear factor kappa B (NF kappa B).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 23)\n  (:start . 14) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "comprise") (:form . "comprise") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 139) (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 168) (:start . 165)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 186)\n  (:start . 179) (:id . 73))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 192)\n  (:start . 187) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 208)\n  (:start . 201) (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 215)\n  (:start . 209) (:id . 78))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 221)\n  (:start . 216) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 223) (:start . 222)\n  (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 225) (:start . 224)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 227) (:start . 225)\n  (:id . 82))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 233)\n  (:start . 228) (:id . 83))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 235) (:start . 234)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 236) (:start . 235)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s680.4) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006303@unknown@formal@none@1@S@The corresponding region in the second AIDS retrovirus, HIV-2, contains a conserved and a divergent NF kappa B binding site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "retrovirus") (:form . "retrovirus") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-2") (:form . "HIV-2") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s680.5) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006304@unknown@formal@none@1@S@We demonstrate that the HIV-1 LTR responds better than the HIV-2 LTR to T cell activation signals.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 49) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s680.6) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006305@unknown@formal@none@1@S@These qualitative differences in the response to T cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a heterologous promoter but also when these enhancers are switched between their respective LTR.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "qualitative") (:form . "qualitative") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "reproduce") (:form . "reproduced") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 101)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "place") (:form . "placed") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 158)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 176) (:start . 172)\n  (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 187)\n  (:start . 182) (:id . 71))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 197)\n  (:start . 188) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "switch") (:form . "switched") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 218)\n  (:start . 211) (:id . 75))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 235)\n  (:start . 225) (:id . 77))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 239) (:start . 236)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s680.7) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006306@unknown@formal@none@1@S@In electrophoretic mobility shift assays, NF kappa B binds to both conserved sites in the HIV-1 transcriptional enhancer and only to the single conserved site in the HIV-2 transcriptional enhancer.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 111) (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 143)\n  (:start . 137) (:id . 65))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 187) (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 196)\n  (:start . 188) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s680.8) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006307@unknown@formal@none@1@S@Instead of NF kappa B, the activator protein 3 binds to the divergent site in HIV-2.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 36)\n  (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 69)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x680.9.1) (:span 0 7)))\n (:nscopes ((:id . :x680.9.1) (:span 0 21)))\n (:identifiers (:sid . :s680.9) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006308@unknown@formal@none@1@S@In conclusion, HIV-1 and HIV-2 are differentially regulated by T cell activation signals, and this difference may account for the longer period of viral latency observed with HIV-2 than with HIV-1 infection.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-2") (:form . "HIV-2") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 49) (:start . 35) (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 143)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 180)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 206)\n  (:start . 197) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x680.10.1) (:span 110 113)))\n (:hscopes ((:id . :x680.10.1) (:span 110 206)))\n (:identifiers (:sid . :s680.10) (:did . :|2258623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006310@unknown@formal@none@1@S@We used mouse embryonic stem (ES) cells to study globin gene expression and switching in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 48) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 55)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s681.2) (:did . :|2269427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006311@unknown@formal@none@1@S@We show that ES-derived embryoid bodies express the full complement of mouse embryonic globin genes in the correct temporal order and that on further differentiation, a switch occurs to the fetal/adult genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "es-derived") (:form . "ES-derived") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "embryoid") (:form . "embryoid") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 39) (:start . 33)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 165) (:start . 150) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "fetal/adult") (:form . "fetal/adult") (:end . 201)\n  (:start . 190) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 207)\n  (:start . 202) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s681.3) (:did . :|2269427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006312@unknown@formal@none@1@S@In addition, the erythroid-specific transcription factor NF-E1 was shown to be expressed coordinately with that of globin in embryoid bodies.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 35) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "nf-e1") (:form . "NF-E1") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "embryoid") (:form . "embryoid") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 140)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s681.4) (:did . :|2269427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006313@unknown@formal@none@1@S@We conclude from these experiments that the ES cell system provides a good model to study hematopoietic development.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 103) (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s681.5) (:did . :|2269427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006314@unknown@formal@none@1@S@When the human epsilon- or beta-globin genes driven by the dominant control region (DCR) are introduced into this system, the human epsilon-globin gene, in contrast to the beta-globin gene, is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "epsilon-") (:form . "epsilon-") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . 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5006315@unknown@formal@none@1@S@We conclude from this that the epsilon-globin gene is not regulated by competition with other genes in the human beta-globin locus.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "epsilon-globin") (:form . "epsilon-globin")\n  (:end . 45) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x681.7.1) (:span 54 57)))\n (:nscopes ((:id . :x681.7.1) (:span 27 130)))\n (:identifiers (:sid . :s681.7) (:did . :|2269427|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006316@unknown@formal@none@1@S@Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cis-linked") (:form . "cis-linked") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s682.1) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006317@unknown@formal@none@1@S@Two consensus sequences, called X and Y boxes, capable of binding nuclear proteins and regulating expression in B cells have been defined within the immediate upstream region of major histocompatibility complex (MHC) class II promoters.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Y") (:form . "Y") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 174)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 202) (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 210)\n  (:start . 203) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 212) (:start . 211)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 215) (:start . 212)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 222)\n  (:start . 217) (:id . 78))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 225) (:start . 223)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 235)\n  (:start . 226) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s682.2) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006318@unknown@formal@none@1@S@Unlike other class II promoters, the HLA-DR alpha (DRA) promoter also contains one element identical to the "octamer" motif of immunoglobulin variable region promoters that is responsible for B cell-specific transcription.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "\\"octamer") (:form . "\\"octamer") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 141) (:start . 127) (:id . 66))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 157)\n  (:start . 151) (:id . 68))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 187)\n  (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 191) (:start . 188)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 207) (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 221) (:start . 208) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s682.3) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006320@unknown@formal@none@1@S@In order to characterize the function of cis-acting elements, we have developed an in vitro system in which a DRA promoter construct is transcribed more efficiently in extracts from B cells than in extracts from class II-negative HeLa cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 147)\n  (:start . 136) (:id . 66))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 164)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 176)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 73))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 206)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 211) (:start . 207)\n  (:id . 77))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 217)\n  (:start . 212) (:id . 78))\n ((:tag . "JJ") (:stem . "ii-negative") (:form . "II-negative") (:end . 229)\n  (:start . 218) (:id . 79))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 234) (:start . 230)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s682.5) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006321@unknown@formal@none@1@S@5' deletion constructs which lacked the Y box, but retained the "octamer" motif and TATA box were completely inactive, and internal deletion of the Y box reduced transcription by 95%.@(((:tag . "CD") (:stem . "5") (:form . "5") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 11)\n  (:start . 3) (:id . 44))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "lack") (:form . "lacked") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "retain") (:form . "retained") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "\\"octamer") (:form . "\\"octamer") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 97) (:start . 93)\n  (:id . 61))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 108)\n  (:start . 98) (:id . 62))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 131)\n  (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 140)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Y") (:form . "Y") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 153) (:start . 150)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 161)\n  (:start . 154) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 74))\n ((:tag . "CD") (:stem . "95") (:form . "95") (:end . 181) (:start . 179)\n  (:id . 75))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 182) (:start . 181)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x682.6.1) (:span 29 35)))\n (:nscopes ((:id . :x682.6.1) (:span 29 45)))\n (:identifiers (:sid . :s682.6) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006322@unknown@formal@none@1@S@Using supercoiled, but not linear templates, we observed differences in transcription efficiencies from templates lacking or disrupting the X consensus element that reflect effects of random replacement of X box sequences in transient expression assays.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "supercoile") (:form . "supercoiled") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "template") (:form . "templates") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "efficiency") (:form . "efficiencies") (:end . 98)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "template") (:form . "templates") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "disrupt") (:form . "disrupting") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 151)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "reflect") (:form . "reflect") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 180)\n  (:start . 173) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 190)\n  (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 202)\n  (:start . 191) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 207) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 211) (:start . 208)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 221)\n  (:start . 212) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 234)\n  (:start . 225) (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 245)\n  (:start . 235) (:id . 77))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 252)\n  (:start . 246) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x682.7.2) (:span 122 124)))\n (:ncues ((:id . :x682.7.1) (:span 114 121))\n  ((:id . :x682.7.3) (:span 23 26)))\n (:hscopes ((:id . :x682.7.2) (:span 114 121)))\n (:nscopes ((:id . :x682.7.1) (:span 114 159))\n  ((:id . :x682.7.3) (:span 23 43)))\n (:identifiers (:sid . :s682.7) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006323@unknown@formal@none@1@S@Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter, the DRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in B cells.@(((:tag . "NN") (:stem . "demonstration") (:form . "Demonstration")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 108)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "\\"octamer") (:form . "\\"octamer") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 163) (:start . 159)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "VB") (:stem . "utilize") (:form . "utilize") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 181)\n  (:start . 176) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 186) (:start . 185)\n  (:id . 75))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 193)\n  (:start . 187) (:id . 76))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 203)\n  (:start . 194) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 221) (:start . 207) (:id . 79))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 231)\n  (:start . 222) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 234) (:start . 232)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 236) (:start . 235)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 242)\n  (:start . 237) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x682.8.2) (:span 69 77)))\n (:ncues ((:id . :x682.8.1) (:span 164 167)))\n (:hscopes ((:id . :x682.8.2) (:span 69 242)))\n (:nscopes ((:id . :x682.8.1) (:span 164 242)))\n (:identifiers (:sid . :s682.8) (:did . :|2278044|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006324@unknown@formal@none@1@S@Characterization of the human immunodeficiency virus type 1 enhancer-binding proteins from the human T-cell line Jurkat.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 46) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "enhancer-binding") (:form . "enhancer-binding")\n  (:end . 76) (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 85)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 112) (:start . 108)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 119)\n  (:start . 113) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s683.1) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006325@unknown@formal@none@1@S@The transcription of the human immunodeficiency virus type 1 (HIV-1) is under the control of cellular proteins that bind to the viral long terminal repeat (LTR).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 47) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 154)\n  (:start . 148) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s683.2) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006326@unknown@formal@none@1@S@Among the protein-binding regions of the HIV-1 LTR is the transcription-enhancer region.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "protein-binding") (:form . "protein-binding")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcription-enhancer")\n  (:form . "transcription-enhancer") (:end . 80) (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s683.3) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006327@unknown@formal@none@1@S@We show that at least one inducible, C1, and one constitutive, C2, protein can bind to the HIV enhancer in Jurkat cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "C1") (:form . "C1") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 48) (:start . 45)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 61)\n  (:start . 49) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C2") (:form . "C2") (:end . 65) (:start . 63)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 83) (:start . 79)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 94) (:start . 91)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 103)\n  (:start . 95) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 113)\n  (:start . 107) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s683.4) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006328@unknown@formal@none@1@S@The two proteins differ in their surface charge, since they are separable by anion-exchange chromatography.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 32)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "charge") (:form . "charge") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "separable") (:form . "separable") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "anion-exchange") (:form . "anion-exchange")\n  (:end . 91) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 106) (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s683.5) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006330@unknown@formal@none@1@S@Both C1 and C2 proteins also bind to a similar sequence found in the interleukin-2-receptor alpha-subunit enhancer.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c1") (:form . "C1") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c2") (:form . "C2") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interleukin-2-receptor")\n  (:form . "interleukin-2-receptor") (:end . 91) (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "alpha-subunit") (:form . "alpha-subunit")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s683.7) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006331@unknown@formal@none@1@S@The inducible C1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a 47 kDa protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "c1") (:form . "C1") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "chromatographic") (:form . "chromatographic")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 96) (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "u.v.") (:form . "u.v.") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 118) (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s683.8) (:did . :|2302185|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006332@unknown@formal@none@1@S@The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 30) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "protein(s)") (:form . "protein(s)") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 91) (:start . 77) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s684.1) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006333@unknown@formal@none@1@S@All immunoglobulin genes contain a conserved octanucleotide promoter element, ATGCAAAT, which has been shown to be required for their normal B-cell-specific transcription.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "octanucleotide") (:form . "octanucleotide")\n  (:end . 59) (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ATGCAAAT") (:form . "ATGCAAAT") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 140)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 156) (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 170) (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s684.2) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006334@unknown@formal@none@1@S@Proteins that bind this octamer have been purified, and cDNAs encoding octamer-binding proteins have been cloned.@(((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 86) (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s684.3) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006335@unknown@formal@none@1@S@Some of these proteins (referred to as OTF-2) are lymphoid specific, whereas at least one other, and possibly more (referred to as OTF-1), is found ubiquitously in all cell types.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 109)\n  (:start . 101) (:id . 63))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 114) (:start . 110)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 124)\n  (:start . 116) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 68))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 136)\n  (:start . 131) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 141) (:start . 139)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 147)\n  (:start . 142) (:id . 73))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 160)\n  (:start . 148) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 75))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 167) (:start . 164)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 178)\n  (:start . 173) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x684.4.1) (:span 101 109)))\n (:hscopes ((:id . :x684.4.1) (:span 101 114)))\n (:identifiers (:sid . :s684.4) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006336@unknown@formal@none@1@S@The exact role of these different proteins in directing the tissue-specific expression of immunoglobulin genes is unclear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "direct") (:form . "directing") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 75) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 104) (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x684.5.1) (:span 114 121)))\n (:hscopes ((:id . :x684.5.1) (:span 0 121)))\n (:identifiers (:sid . :s684.5) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006337@unknown@formal@none@1@S@We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pre-b-cell") (:form . "pre-B-cell") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "yet") (:form . "yet") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 134)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 149) (:start . 135) (:id . 63))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 161)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 166) (:start . 162)\n  (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 190)\n  (:start . 179) (:id . 69))\n ((:tag . "VBP") (:stem . "transcribe") (:form . "transcribe") (:end . 201)\n  (:start . 191) (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 219) (:start . 205) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 224) (:start . 220)\n  (:id . 73))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 74))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 233)\n  (:start . 228) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s684.6) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006338@unknown@formal@none@1@S@Addition of a highly enriched preparation of OTF-1 made from one of these pre-B cells or from HeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "preparation") (:form . "preparation") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 117)\n  (:start . 105) (:id . 61))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 151) (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 172) (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s684.7) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006340@unknown@formal@none@1@S@These results suggest that OTF-1, without OTF-2, is sufficient for transcription of immunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "otf-1") (:form . "OTF-1") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 98) (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 144)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 168) (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 179)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 197) (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 202) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 213)\n  (:start . 203) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x684.9.3) (:span 14 21)))\n (:ncues ((:id . :x684.9.1) (:span 129 132))\n  ((:id . :x684.9.2) (:span 34 41)))\n (:hscopes ((:id . :x684.9.3) (:span 14 213)))\n (:nscopes ((:id . :x684.9.1) (:span 129 213))\n  ((:id . :x684.9.2) (:span 34 47)))\n (:identifiers (:sid . :s684.9) (:did . :|2304473|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006341@unknown@formal@none@1@S@Tax-independent binding of multiple cellular factors to Tax-response element DNA of HTLV-I.@(((:tag . "JJ") (:stem . "tax-independent") (:form . "Tax-independent")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tax-response") (:form . "Tax-response") (:end . 68)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s685.1) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006342@unknown@formal@none@1@S@The human T-cell leukemia virus type I (HTLV-I) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE (Tax-response element) that is responsive to the virally encoded transactivator protein Tax.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 78) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "imperfect") (:form . "imperfect") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "21-base") (:form . "21-base") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "tax-response") (:form . "Tax-response") (:end . 163)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 180) (:start . 178)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 191)\n  (:start . 181) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 76))\n ((:tag . "RB") (:stem . "virally") (:form . "virally") (:end . 206)\n  (:start . 199) (:id . 77))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 214)\n  (:start . 207) (:id . 78))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 229) (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 237)\n  (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 241) (:start . 238)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s685.2) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006343@unknown@formal@none@1@S@We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax-expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE-DNA, none of which are identical with the Tax-protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C81-66-45") (:form . "C81-66-45") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "immortalize") (:form . "immortalized") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 114) (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 133) (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Salahuddin") (:form . "Salahuddin") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1983") (:form . "1983") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TRE-DNA") (:form . "TRE-DNA") (:end . 196)\n  (:start . 189) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 202) (:start . 198)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 211)\n  (:start . 206) (:id . 77))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 215) (:start . 212)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 225)\n  (:start . 216) (:id . 79))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 230) (:start . 226)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Tax-protein") (:form . "Tax-protein") (:end . 246)\n  (:start . 235) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x685.3.1) (:span 198 202)))\n (:nscopes ((:id . :x685.3.1) (:span 198 246)))\n (:identifiers (:sid . :s685.3) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006344@unknown@formal@none@1@S@The proteins identified have molecular weights of about 32, 36 to 42, 50 and 110 kD.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "weight") (:form . "weights") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "CD") (:stem . "110") (:form . "110") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 83) (:start . 81)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s685.4) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006345@unknown@formal@none@1@S@Four different methods were used to identify the proteins.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s685.5) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006346@unknown@formal@none@1@S@First, from different cell lines three or all four of the nuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled TRE-DNA fragment.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 92)\n  (:start . 80) (:id . 57))\n ((:tag . "VBN") (:stem . "cross-linke") (:form . "cross-linked") (:end . 105)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 123)\n  (:start . 112) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "RB") (:stem . "radioactively") (:form . "radioactively")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "VBN") (:stem . "label") (:form . "labeled") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "JJ") (:stem . "tre-dna") (:form . "TRE-DNA") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 169)\n  (:start . 161) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s685.6) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006347@unknown@formal@none@1@S@Second, TRE-DNA binding proteins sedimented through a glycerol density gradient at rates corresponding to proteins of native molecular weights of 35 to 50 kD and 110 kD.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "TRE-DNA") (:form . "TRE-DNA") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "sedimente") (:form . "sedimented") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "glycerol") (:form . "glycerol") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "gradient") (:form . "gradient") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 102)\n  (:start . 89) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "weight") (:form . "weights") (:end . 142)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "CD") (:stem . "110") (:form . "110") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s685.7) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006348@unknown@formal@none@1@S@Third, only the 50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNA fragment contained the TRE-DNA.@(((:tag . "RB") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 42)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "biotinylate") (:form . "biotinylated") (:end . 60)\n  (:start . 48) (:id . 53))\n ((:tag . "NNP") (:stem . "DNA-streptavidin") (:form . "DNA-streptavidin")\n  (:end . 77) (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tre-dna") (:form . "TRE-DNA") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s685.8) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006350@unknown@formal@none@1@S@Two abundant proteins of 75 and 80 kD were competed out by poly[d(I-C)] in all reactions.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "compete") (:form . "competed") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "poly[d(I-C)") (:form . "poly[d(I-C)") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 88)\n  (:start . 79) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s685.10) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006351@unknown@formal@none@1@S@The cAMP-response element CRE, TGACGTCA, present in the 21 base-pair sequence, appears to be essential for specific protein-TRE-DNA interactions because mutation of the two G's destroys this complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "camp-response") (:form . "cAMP-response")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TGACGTCA") (:form . "TGACGTCA") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "base-pair") (:form . "base-pair") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "JJ") (:stem . "protein-tre-dna") (:form . "protein-TRE-DNA")\n  (:end . 131) (:start . 116) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 144)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 161)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "destroy") (:form . "destroys") (:end . 185)\n  (:start . 177) (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 198)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x685.11.1) (:span 79 86)))\n (:hscopes ((:id . :x685.11.1) (:span 0 144)))\n (:identifiers (:sid . :s685.11) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006352@unknown@formal@none@1@S@This result suggests that the cAMP response element binding protein, CREB, is involved in the protein-TRE-DNA complex and in mediating the Tax response.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "protein-tre-dna") (:form . "protein-TRE-DNA")\n  (:end . 109) (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x685.12.1) (:span 12 20)))\n (:hscopes ((:id . :x685.12.1) (:span 12 151)))\n (:identifiers (:sid . :s685.12) (:did . :|2314899|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006353@unknown@formal@none@1@S@Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 114) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 156) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 167)\n  (:start . 157) (:id . 65))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 172)\n  (:start . 168) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "VB") (:stem . "assay") (:form . "assay") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 197) (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 206)\n  (:start . 198) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 212) (:start . 210)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 223)\n  (:start . 213) (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 231)\n  (:start . 224) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 238)\n  (:start . 232) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s686.1) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006354@unknown@formal@none@1@S@Nuclear factor of activated T-cells (NFAT-1) is a transcription factor which is considered to be an important regulator in early T-cell activation.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x686.2.1) (:span 80 90)))\n (:hscopes ((:id . :x686.2.1) (:span 71 146)))\n (:identifiers (:sid . :s686.2) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006355@unknown@formal@none@1@S@We have developed a system to monitor the transcriptional activity of NFAT-1 at the single cell level in whole animals.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "monitor") (:form . "monitor") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 57) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s686.3) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006356@unknown@formal@none@1@S@The system is based on the use of an oligomerized NFAT-1 binding motif that directs transcription of SV40 T-antigen in transgenic mice.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "oligomerized") (:form . "oligomerized") (:end . 49)\n  (:start . 37) (:id . 51))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t-antigen") (:form . "T-antigen") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 134)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s686.4) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006357@unknown@formal@none@1@S@This report represents the first demonstration that a multimerized short binding motif can function appropriately in transgenic mice.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "RB") (:stem . "appropriately") (:form . "appropriately")\n  (:end . 113) (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 127)\n  (:start . 117) (:id . 58))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 132)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s686.5) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006358@unknown@formal@none@1@S@NFAT-1 activity had previously been thought to be confined to activated T-lymphocytes upon release of intracellular calcium.@(((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "confine") (:form . "confined") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x686.6.1) (:span 36 43)))\n (:hscopes ((:id . :x686.6.1) (:span 0 123)))\n (:identifiers (:sid . :s686.6) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006360@unknown@formal@none@1@S@Besides in T-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C.@(((:tag . "IN") (:stem . "besides") (:form . "Besides") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "t-lymphocyte-depleted")\n  (:form . "T-lymphocyte-depleted") (:end . 87) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "NNS") (:stem . "b-lymphocyte") (:form . "B-lymphocytes")\n  (:end . 127) (:start . 114) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 140)\n  (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 147)\n  (:start . 141) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 165)\n  (:start . 158) (:id . 63))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 179) (:start . 166) (:id . 64))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 187)\n  (:start . 180) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 200)\n  (:start . 192) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 208)\n  (:start . 201) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 215)\n  (:start . 209) (:id . 69))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 217) (:start . 216)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s686.8) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006361@unknown@formal@none@1@S@A difference in the time course of appearance of NFAT-1 activity between T-lymphocytes and non-T-lymphocytes was revealed.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "non-t-lymphocyte") (:form . "non-T-lymphocytes")\n  (:end . 108) (:start . 91) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s686.9) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006362@unknown@formal@none@1@S@Constitutive expression was observed in a small population of cells in the dermis and some mice have developed skin lesions.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dermis") (:form . "dermis") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s686.10) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006363@unknown@formal@none@1@S@Interestingly, the tissue pattern of expression of the NFAT-1 activity resembles the expression pattern described for HIV-LTR/tat transgenic mice (Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., and Jay, G. (1988) Nature 335, 606-611).@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . 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(:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Reynolds") (:form . "Reynolds") (:end . 183)\n  (:start . 175) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 187) (:start . 185)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "K.") (:form . "K.") (:end . 190) (:start . 188)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Luciw") (:form . "Luciw") (:end . 197)\n  (:start . 192) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "P.") (:form . "P.") (:end . 201) (:start . 199)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "A.") (:form . "A.") (:end . 204) (:start . 202)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Jay") (:form . "Jay") (:end . 213) (:start . 210)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 217) (:start . 215)\n  (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 86))\n ((:tag . "CD") (:stem . "1988") (:form . "1988") (:end . 223) (:start . 219)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "Nature") (:form . "Nature") (:end . 231)\n  (:start . 225) (:id . 89))\n ((:tag . "CD") (:stem . "335") (:form . "335") (:end . 235) (:start . 232)\n  (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 236) (:start . 235)\n  (:id . 91))\n ((:tag . "CD") (:stem . "606-611") (:form . "606-611") (:end . 244)\n  (:start . 237) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 245) (:start . 244)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s686.11) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006364@unknown@formal@none@1@S@This similarity in expression and the fact that NFAT-1 has been shown to bind functional sequences in HIV-LTR suggest a role for NFAT-1 in dermal activation of the HIV-LTR.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT-1") (:form . "NFAT-1") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-LTR") (:form . "HIV-LTR") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dermal") (:form . "dermal") (:end . 145)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hiv-ltr") (:form . "HIV-LTR") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x686.12.1) (:span 110 117)))\n (:hscopes ((:id . :x686.12.1) (:span 110 171)))\n (:identifiers (:sid . :s686.12) (:did . :|2394747|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006365@unknown@formal@none@1@S@NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 79) (:start . 57) (:id . 50))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 98) (:start . 80) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 105)\n  (:start . 99) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s687.1) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006366@unknown@formal@none@1@S@The expression of the gene encoding the granulocyte-macrophage colony-stimulating factor (GM-CSF) is induced upon activation of T cells with phytohemagglutinin and active phorbolester and upon expression of tax1, a transactivating protein of the human T-cell leukemia virus type I.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 62) (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 81) (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 96)\n  (:start . 90) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 159) (:start . 141) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 170)\n  (:start . 164) (:id . 65))\n ((:tag . "NN") (:stem . "phorbolester") (:form . "phorbolester") (:end . 183)\n  (:start . 171) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 67))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 192) (:start . 188)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 203)\n  (:start . 193) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tax1") (:form . "tax1") (:end . 211) (:start . 207)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 214) (:start . 213)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 230) (:start . 215) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 238)\n  (:start . 231) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 251)\n  (:start . 246) (:id . 78))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 258)\n  (:start . 252) (:id . 79))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 267)\n  (:start . 259) (:id . 80))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 273)\n  (:start . 268) (:id . 81))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 278) (:start . 274)\n  (:id . 82))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 280) (:start . 279)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s687.2) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006367@unknown@formal@none@1@S@The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes, depending on promoter elements that bind the inducible transcription factor NF-kappa B (or an NF-kappa B-like factor).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 98) (:start . 85) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 115)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 160)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 174) (:start . 161) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 181)\n  (:start . 175) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 190)\n  (:start . 182) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 192) (:start . 191)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 196) (:start . 194)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 208)\n  (:start . 200) (:id . 71))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 215)\n  (:start . 209) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 222)\n  (:start . 216) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s687.3) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006368@unknown@formal@none@1@S@We therefore tested the possibility that the GM-CSF gene is also regulated by a cognate motif for the NF-kappa B transcription factor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 19) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 126) (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x687.4.1) (:span 24 35)))\n (:hscopes ((:id . :x687.4.1) (:span 24 133)))\n (:identifiers (:sid . :s687.4) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006370@unknown@formal@none@1@S@Using electrophoretic mobility shift assays, we showed binding of purified human NF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 54) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 163) (:start . 148) (:id . 68))\n ((:tag . "VBG") (:stem . "comprise") (:form . "comprising") (:end . 174)\n  (:start . 164) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 214)\n  (:start . 203) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 218) (:start . 215)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 228)\n  (:start . 219) (:id . 76))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 243) (:start . 229) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 246) (:start . 244)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "t-cell-activating") (:form . "T-cell-activating")\n  (:end . 264) (:start . 247) (:id . 79))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 272)\n  (:start . 265) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 276) (:start . 273)\n  (:id . 81))\n ((:tag . "NN") (:stem . "tax1") (:form . "tax1") (:end . 281) (:start . 277)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s687.6) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006371@unknown@formal@none@1@S@As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 (GGGAACTACC) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter (GGGAAATTCC).@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 25)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 67) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 79)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "CD") (:stem . "-82") (:form . "-82") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-91") (:form . "-91") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GGGAACTACC") (:form . "GGGAACTACC") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 169)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 204)\n  (:start . 196) (:id . 73))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 212)\n  (:start . 205) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 215) (:start . 213)\n  (:id . 75))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 220) (:start . 216)\n  (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 225) (:start . 221)\n  (:id . 77))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 231)\n  (:start . 226) (:id . 78))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 234) (:start . 232)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 240)\n  (:start . 235) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 243) (:start . 241)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 82))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 260)\n  (:start . 248) (:id . 83))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 271)\n  (:start . 261) (:id . 84))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 277)\n  (:start . 272) (:id . 85))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 279) (:start . 278)\n  (:id . 86))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 285)\n  (:start . 280) (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 288) (:start . 286)\n  (:id . 88))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 292) (:start . 289)\n  (:id . 89))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 297) (:start . 293)\n  (:id . 90))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 308)\n  (:start . 298) (:id . 91))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 317)\n  (:start . 309) (:id . 92))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 319) (:start . 318)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "GGGAAATTCC") (:form . "GGGAAATTCC") (:end . 329)\n  (:start . 319) (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 330) (:start . 329)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 331) (:start . 330)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s687.7) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006372@unknown@formal@none@1@S@Two kappa B-like motifs at positions -98 to -108 of the GM-CSF promoter were also recognized but with much lower affinities.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "-98") (:form . "-98") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-108") (:form . "-108") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 112) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s687.8) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006373@unknown@formal@none@1@S@Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B transcription factor to a high-affinity binding site in the GM-CSF promoter.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 156) (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 182) (:start . 169) (:id . 69))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 190)\n  (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 195) (:start . 191)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 209)\n  (:start . 203) (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 218)\n  (:start . 210) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s687.9) (:did . :|2406568|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006374@unknown@formal@none@1@S@Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression.@(((:tag . "NNP") (:stem . "Octamer") (:form . "Octamer") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type-specificity") (:form . "type-specificity")\n  (:end . 59) (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 77) (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s688.1) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006375@unknown@formal@none@1@S@Antibodies are produced exclusively in B lymphocytes.@(((:tag . "NNS") (:stem . "antibody") (:form . "Antibodies") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s688.2) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006376@unknown@formal@none@1@S@The expression of the antibody-encoding genes, the immunoglobulin (Ig) genes, is also restricted to B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antibody-encoding") (:form . "antibody-encoding")\n  (:end . 39) (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "restrict") (:form . "restricted") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s688.3) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006377@unknown@formal@none@1@S@The octamer sequence ATGCAAAT is present in the promoter and the enhancer of Ig genes, and plays an important role in its tissue-specific expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "atgcaaat") (:form . "ATGCAAAT") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 137) (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s688.4) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006378@unknown@formal@none@1@S@This sequence motif is a binding site for nuclear proteins, the so-called octamer transcription factors (Oct or OTF factors).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "OTF") (:form . "OTF") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s688.5) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006380@unknown@formal@none@1@S@All three proteins show the same sequence specificity and binding affinity.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s688.7) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006381@unknown@formal@none@1@S@It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell type-specific Oct factors, and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 109) (:start . 96) (:id . 60))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "quantitative") (:form . "quantitative") (:end . 159)\n  (:start . 147) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "qualitative") (:form . "qualitative") (:end . 175)\n  (:start . 164) (:id . 71))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 187)\n  (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 195)\n  (:start . 188) (:id . 73))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 201)\n  (:start . 196) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 211)\n  (:start . 206) (:id . 76))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 219)\n  (:start . 212) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x688.8.1) (:span 3 10)))\n (:hscopes ((:id . :x688.8.1) (:span 3 219)))\n (:identifiers (:sid . :s688.8) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006382@unknown@formal@none@1@S@Recently, a number of other octamer factor variants were identified.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s688.9) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006383@unknown@formal@none@1@S@Many of these may be created by alternative splicing of a primary transcript of one Oct factor gene and may serve a specific function in the fine tuning of gene expression.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 43)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 133)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "fine") (:form . "fine") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tuning") (:form . "tuning") (:end . 152)\n  (:start . 146) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 160) (:start . 156)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x688.10.1) (:span 104 107))\n  ((:id . :x688.10.2) (:span 14 17)))\n (:hscopes ((:id . :x688.10.1) (:span 104 171))\n  ((:id . :x688.10.2) (:span 0 99)))\n (:identifiers (:sid . :s688.10) (:did . :|2407588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006384@unknown@formal@none@1@S@ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin.@(((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "transactivate") (:form . "transactivates")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s689.1) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006385@unknown@formal@none@1@S@Activation of T helper cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 114) (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 129) (:start . 116) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "haematopoietic") (:form . "haematopoietic")\n  (:end . 166) (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 173)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s689.2) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006386@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one such cytokine whose increased expression results partly from increases in transcription.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 56)\n  (:start . 50) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 113)\n  (:start . 106) (:id . 55))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 120)\n  (:start . 114) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s689.3) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006387@unknown@formal@none@1@S@Cis-acting elements with NF kappa B, AP-1 and ETS-like motifs have been identified in the promoter region of the GM-CSF gene, which are important for transcriptional activity following PMA and ionomycin stimulation.@(((:tag . "JJ") (:stem . "cis-acting") (:form . "Cis-acting") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ets-like") (:form . "ETS-like") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 145)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 165) (:start . 150) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 174)\n  (:start . 166) (:id . 70))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 184)\n  (:start . 175) (:id . 71))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 202)\n  (:start . 193) (:id . 74))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 214)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s689.4) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006388@unknown@formal@none@1@S@A number of the ETS family of transcription factors are expressed in T cells, including ETS1 and ELF1.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ELF1") (:form . "ELF1") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s689.5) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006390@unknown@formal@none@1@S@Exogenous ETS1, but not ELF1, can transactivate GM-CSF, through the GM5 site, in a PMA/ionomycin dependent manner.@(((:tag . "JJ") (:stem . "exogenous") (:form . "Exogenous") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "elf1") (:form . "ELF1") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 47) (:start . 34) (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GM5") (:form . "GM5") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PMA/ionomycin") (:form . "PMA/ionomycin")\n  (:end . 96) (:start . 83) (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 106)\n  (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x689.7.1) (:span 20 23)))\n (:nscopes ((:id . :x689.7.1) (:span 20 28)))\n (:identifiers (:sid . :s689.7) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006391@unknown@formal@none@1@S@Other unidentified ETS-like factors present in Jurkat cells are also capable of binding GM5.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "ets-like") (:form . "ETS-like") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "gm5") (:form . "GM5") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s689.8) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006392@unknown@formal@none@1@S@Mutation of the core ETS binding site from -GGAA- to -GGAT- prevents the binding of ETS-like factors with the exception of ETS1.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ets") (:form . "ETS") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "-ggaa-") (:form . "-GGAA-") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "-GGAT-") (:form . "-GGAT-") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ets-like") (:form . "ETS-like") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x689.9.1) (:span 101 122)))\n (:nscopes ((:id . :x689.9.1) (:span 101 127)))\n (:identifiers (:sid . :s689.9) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006393@unknown@formal@none@1@S@The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ets1") (:form . "ETS1") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 82)\n  (:start . 72) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA/ionomycin") (:form . "PMA/ionomycin")\n  (:end . 99) (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ets1") (:form . "ETS1") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 146) (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 183)\n  (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s689.10) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006394@unknown@formal@none@1@S@Together these data suggest that ETS1 may be involved in mediating the increased GM-CSF production associated with T cell activation.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ets1") (:form . "ETS1") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x689.11.1) (:span 38 41))\n  ((:id . :x689.11.2) (:span 20 27)))\n (:hscopes ((:id . :x689.11.1) (:span 33 132))\n  ((:id . :x689.11.2) (:span 20 132)))\n (:identifiers (:sid . :s689.11) (:did . :|7478534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006395@unknown@formal@none@1@S@Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.@(((:tag . "JJ") (:stem . "tissue-specific") (:form . "Tissue-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "15-lipoxygenase") (:form . "15-lipoxygenase")\n  (:end . 56) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s690.1) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006396@unknown@formal@none@1@S@The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner, predominantly in erythroid cells but also in airway epithelial cells and eosinophils.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "15-lipoxygenase") (:form . "15-lipoxygenase")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lox") (:form . "lox") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 64) (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 86) (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "airway") (:form . "airway") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 157)\n  (:start . 146) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s690.2) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006397@unknown@formal@none@1@S@We demonstrate in this report that the 5' flanking DNA of the 15-lox gene contains sequences which down-regulate its activity in a variety of non-erythroid cell lines but not in two erythroid cell lines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "15-lox") (:form . "15-lox") (:end . 68)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "down-regulate") (:form . "down-regulate")\n  (:end . 112) (:start . 99) (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "non-erythroid") (:form . "non-erythroid")\n  (:end . 155) (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 202)\n  (:start . 197) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x690.3.1) (:span 171 174)))\n (:nscopes ((:id . :x690.3.1) (:span 171 202)))\n (:identifiers (:sid . :s690.3) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006398@unknown@formal@none@1@S@The element has characteristics of a transcriptional 'silencer' since it functions in both orientations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 31) (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 52) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "'silencer") (:form . "'silencer") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "orientation") (:form . "orientations") (:end . 103)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s690.4) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006400@unknown@formal@none@1@S@These binding sites have similar sequences and multiple copies of the binding sites confer tissue-specific down-regulation when attached to a minimal lox promoter fragment.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 13) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 62) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "confer") (:form . "confer") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 106) (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 122) (:start . 107) (:id . 57))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "attach") (:form . "attached") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "lox") (:form . "lox") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 171)\n  (:start . 163) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s690.6) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006401@unknown@formal@none@1@S@The 5' flanking DNA also contains a cluster of three binding sites for the GATA family of transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 15)\n  (:start . 7) (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s690.7) (:did . :|7478994|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006402@unknown@formal@none@1@S@Coexpression of NF-kappa B/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia.@(((:tag . "NNP") (:stem . "Coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 86) (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "1-induced") (:form . "1-induced") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "cell-t-cell") (:form . "cell-T-cell") (:end . 125)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "syncytia") (:form . "syncytia") (:end . 134)\n  (:start . 126) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s691.1) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006403@unknown@formal@none@1@S@Productive infection of T cells with human immunodeficiency virus 1 (HIV-1) typically requires that the T cells be stimulated with antigens or mitogens.@(((:tag . "JJ") (:stem . "productive") (:form . "Productive") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 59) (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s691.2) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006404@unknown@formal@none@1@S@This requirement has been attributed to the activation of the transcription factor NF-kappa B, which synergizes with the constitutive transcription factor Sp1 to drive the HIV-1 promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 100)\n  (:start . 95) (:id . 57))\n ((:tag . "VBZ") (:stem . "synergize") (:form . "synergizes") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 133)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 147) (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 154)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 167)\n  (:start . 162) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s691.3) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006405@unknown@formal@none@1@S@Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated memory T cells after syncytium formation with dendritic cells (DCs).@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "vigorous") (:form . "vigorous") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nonactivated") (:form . "nonactivated") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "syncytium") (:form . "syncytium") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DC") (:form . "DCs") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s691.4) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006406@unknown@formal@none@1@S@These syncytia lack activated cells as determined by an absence of staining for Ki-67 cell cycle antigen.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "syncytia") (:form . "syncytia") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ki-67") (:form . "Ki-67") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x691.5.1) (:span 56 63)) ((:id . :x691.5.2) (:span 15 19)))\n (:nscopes ((:id . :x691.5.1) (:span 56 104))\n  ((:id . :x691.5.2) (:span 15 35)))\n (:identifiers (:sid . :s691.5) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006407@unknown@formal@none@1@S@The expression and activity of NF-kappa B and Sp1 were, therefore, analyzed in isolated T cells and DCs from humans and mice.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "dc") (:form . "DCs") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 124)\n  (:start . 120) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s691.6) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006408@unknown@formal@none@1@S@We have used immunolabeling, Western blot analysis, and electrophoretic mobility shift and supershift assays.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunolabeling") (:form . "immunolabeling")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 71) (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s691.7) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006410@unknown@formal@none@1@S@DCs express high levels of all known NF-kappa B and Rel proteins, with activity residing primarily within RelB, p50, and p65.@(((:tag . "NNS") (:stem . "dc") (:form . "DCs") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "VBG") (:stem . "reside") (:form . "residing") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s691.9) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006411@unknown@formal@none@1@S@However, DCs lack Sp1, which may explain the failure of HIV-1 to replicate in purified DCs.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "DC") (:form . "DCs") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 40)\n  (:start . 33) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 52)\n  (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 74)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 86)\n  (:start . 78) (:id . 58))\n ((:tag . "NNS") (:stem . "dc") (:form . "DCs") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x691.10.2) (:span 29 32)))\n (:ncues ((:id . :x691.10.1) (:span 45 52))\n  ((:id . :x691.10.3) (:span 13 17)))\n (:hscopes ((:id . :x691.10.2) (:span 29 90)))\n (:nscopes ((:id . :x691.10.1) (:span 45 90))\n  ((:id . :x691.10.3) (:span 13 21)))\n (:identifiers (:sid . :s691.10) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006412@unknown@formal@none@1@S@Coexpression of NF-kappa B and Sp1 occurs in the heterologous DC-T-cell syncytia that are induced by HIV-1.@(((:tag . "NNP") (:stem . "Coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "dc-t-cell") (:form . "DC-T-cell") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "syncytia") (:form . "syncytia") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s691.11) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006413@unknown@formal@none@1@S@Therefore, HIV-1-induced cell fusion brings together factors that upregulate virus transcription.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hiv-1-induced") (:form . "HIV-1-induced")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "bring") (:form . "brings") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "upregulate") (:form . "upregulate") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s691.12) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006414@unknown@formal@none@1@S@Since DCs and memory T cells frequently traffic together in situ, these unusual heterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "dc") (:form . "DCs") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "VBP") (:stem . "traffic") (:form . "traffic") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "syncytia") (:form . "syncytia") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "VB") (:stem . "develop") (:form . "develop") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 177)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "JJ") (:stem . "ostensible") (:form . "ostensible") (:end . 196)\n  (:start . 186) (:id . 70))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 203)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 215)\n  (:start . 204) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x691.13.1) (:span 178 185)))\n (:nscopes ((:id . :x691.13.1) (:span 178 215)))\n (:identifiers (:sid . :s691.13) (:did . :|7479915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006415@unknown@formal@none@1@S@Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3 [published erratum appears in Proc Natl Acad Sci U S A 1996 Jan 9;93(1):524]@(((:tag . "NN") (:stem . "down-regulation") (:form . "Down-regulation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 100) (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 103) (:start . 101)\n  (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 130)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Proc") (:form . "Proc") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Natl") (:form . "Natl") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Acad") (:form . "Acad") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Sci") (:form . "Sci") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "CD") (:stem . "1996") (:form . "1996") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jan") (:form . "Jan") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "CD") (:stem . "9;93(1):524") (:form . "9;93(1):524") (:end . 179)\n  (:start . 168) (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s692.1) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006416@unknown@formal@none@1@S@The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2)D3], a steroid hormone with immunomodulating properties, on nuclear factor kappa B (NF-kappa B) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 35) (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "1,25(OH)2)D3") (:form . "1,25(OH)2)D3") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "steroid") (:form . "steroid") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immunomodulating") (:form . "immunomodulating")\n  (:end . 94) (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 196)\n  (:start . 190) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 202)\n  (:start . 197) (:id . 75))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 214)\n  (:start . 203) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 217) (:start . 215)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 225)\n  (:start . 218) (:id . 78))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 230) (:start . 226)\n  (:id . 79))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 239)\n  (:start . 231) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s692.2) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006417@unknown@formal@none@1@S@Over a 72-hr period of activation, the expression of the 50-kDa NF-kappa B, p50, and its precursor, p105, was increased progressively.@(((:tag . "IN") (:stem . "over") (:form . "Over") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "72-hr") (:form . "72-hr") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "50-kda") (:form . "50-kDa") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 98)\n  (:start . 89) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 104) (:start . 100)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 119)\n  (:start . 110) (:id . 66))\n ((:tag . "RB") (:stem . "progressively") (:form . "progressively")\n  (:end . 133) (:start . 120) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s692.3) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006418@unknown@formal@none@1@S@When cells were activated in the presence of 1,25(OH)2D3, the levels of the mature protein as well as its precursor were decreased.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 115)\n  (:start . 106) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 130)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s692.4) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006420@unknown@formal@none@1@S@Besides p50, 1,25(OH)2D3 decreased the levels of another NF-kappa B protein, namely c-rel.@(((:tag . "IN") (:stem . "besides") (:form . "Besides") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s692.6) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006421@unknown@formal@none@1@S@In addition, 1,25(OH)2D3 decreased the abundance of a specific DNA-protein complex formed upon incubation of nuclear extracts from activated lymphocytes with a labeled NF-kappa B DNA binding motif.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 89) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 159) (:start . 158)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "label") (:form . "labeled") (:end . 167)\n  (:start . 160) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 176)\n  (:start . 168) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 190)\n  (:start . 183) (:id . 69))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s692.7) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006422@unknown@formal@none@1@S@Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 130)\n  (:start . 121) (:id . 59))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 153)\n  (:start . 147) (:id . 62))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 161)\n  (:start . 154) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 196)\n  (:start . 188) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 218) (:start . 204) (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 224)\n  (:start . 219) (:id . 73))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 230)\n  (:start . 225) (:id . 74))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 236)\n  (:start . 231) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 241) (:start . 237)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 248)\n  (:start . 242) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 251) (:start . 249)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 255) (:start . 252)\n  (:id . 79))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 271) (:start . 256) (:id . 80))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 289) (:start . 272) (:id . 81))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 298)\n  (:start . 290) (:id . 82))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 303) (:start . 299)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 304) (:start . 303)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s692.8) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006423@unknown@formal@none@1@S@These observations demonstrate directly that there is de novo synthesis of NF-kappa B during human lymphocyte activation and suggest that this process is hormonally regulated.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "RB") (:stem . "hormonally") (:form . "hormonally") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 174)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x692.9.1) (:span 125 132)))\n (:hscopes ((:id . :x692.9.1) (:span 125 174)))\n (:identifiers (:sid . :s692.9) (:did . :|7479923|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006424@unknown@formal@none@1@S@Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s693.1) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006425@unknown@formal@none@1@S@The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor CD28.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "VBN") (:stem . "deliver") (:form . "delivered") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "auxiliary") (:form . "auxiliary") (:end . 118)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 132) (:start . 128)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s693.2) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006426@unknown@formal@none@1@S@Several transcription factors participate in IL-2 promoter activation, among which are AP-1-like factors and NF-kappa B.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 41)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ap-1-like") (:form . "AP-1-like") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s693.3) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006427@unknown@formal@none@1@S@Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun; and (2) it is involved in the release of the cytoplasmic inhibitor, I kappa B, from NF-kappa B, allowing translocation of the latter into the nucleus.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 23) (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . 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"NF-kappa") (:end . 249)\n  (:start . 241) (:id . 90))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 251) (:start . 250)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 252) (:start . 251)\n  (:id . 92))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 261)\n  (:start . 253) (:id . 93))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 275) (:start . 262) (:id . 94))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 278) (:start . 276)\n  (:id . 95))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 282) (:start . 279)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 289)\n  (:start . 283) (:id . 97))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 294) (:start . 290)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 298) (:start . 295)\n  (:id . 99))\n ((:tag . "NN") (:stem . "nucleus") (:form . 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5006428@unknown@formal@none@1@S@We have recently shown that both phosphorylation processes require T-cell costimulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 48) (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s693.5) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006430@unknown@formal@none@1@S@According to our results, however, the kinases responsible for the two processes are distinct entities.@(((:tag . "VBG") (:stem . "accord") (:form . "According") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NNS") (:stem . "entity") (:form . "entities") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s693.7) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006431@unknown@formal@none@1@S@Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B, it markedly enhances the activity of JNK, the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 37) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "consequently") (:form . "consequently") (:end . 68)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "kinase-related") (:form . "kinase-related")\n  (:end . 160) (:start . 146) (:id . 69))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "phosphorylate") (:form . "phosphorylates")\n  (:end . 187) (:start . 173) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 207) (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 214)\n  (:start . 208) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 76))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 223)\n  (:start . 218) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s693.8) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006432@unknown@formal@none@1@S@We, therefore, propose the activation scheme presented in FIGURE 3 for T-cell costimulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 13)\n  (:start . 4) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FIGURE") (:form . "FIGURE") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s693.9) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006433@unknown@formal@none@1@S@Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors, AP-1 and NF-kappa B.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 93)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s693.10) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006434@unknown@formal@none@1@S@Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other.@(((:tag . "NN") (:stem . "integration") (:form . "Integration") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "bifurcate") (:form . "bifurcates") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 148) (:start . 133) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 174)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 71))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 199) (:start . 196)\n  (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 210)\n  (:start . 200) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 220)\n  (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 236) (:start . 221) (:id . 80))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 239) (:start . 237)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 243) (:start . 240)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 249)\n  (:start . 244) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s693.11) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006435@unknown@formal@none@1@S@We are currently engaged in defining where the two signals integrate along the AP-1/NF-kappa B pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "engage") (:form . "engaged") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "define") (:form . "defining") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "integrate") (:form . "integrate") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AP-1/NF-kappa") (:form . "AP-1/NF-kappa")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s693.12) (:did . :|7486667|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006436@unknown@formal@none@1@S@Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha.@(((:tag . "JJ") (:stem . "cupric") (:form . "Cupric") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "nf") (:form . "NF") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "signal-induced") (:form . "signal-induced")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 93) (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s694.1) (:did . :|7488149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006437@unknown@formal@none@1@S@A transcription factor NF kappa B, which regulates expression of various cellular genes involved in immune responses and viral genes including HIV, is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "sequester") (:form . "sequestered") (:end . 162)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 192)\n  (:start . 185) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 200) (:start . 198)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 211)\n  (:start . 201) (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 219)\n  (:start . 212) (:id . 77))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 221) (:start . 220)\n  (:id . 78))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 227)\n  (:start . 222) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 229) (:start . 228)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s694.2) (:did . :|7488149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006438@unknown@formal@none@1@S@Various extracellular signals induce phosphorylation and rapid degradation of I kappa B alpha to release NF kappa B.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 52) (:start . 37) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 62) (:start . 57)\n  (:id . 48))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 74)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 79) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s694.3) (:did . :|7488149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006440@unknown@formal@none@1@S@Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha, indicating that Cu2+ interferes with the dissociation of the NF kappa B-I kappa B complex.@(((:tag . "NNP") (:stem . "Deoxycholate") (:form . "Deoxycholate") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "VBN") (:stem . "prepare") (:form . 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5006441@unknown@formal@none@1@S@Neither phosphorylation nor degradation of I kappa B alpha was observed upon TNF-alpha stimulation in the presence of Cu2+.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 23) (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Cu2+") (:form . "Cu2+") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x694.6.1) (:span 0 7 24 27)))\n (:nscopes ((:id . :x694.6.1) (:span 0 122)))\n (:identifiers (:sid . :s694.6) (:did . :|7488149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006442@unknown@formal@none@1@S@These results indicate that Cu2+ inhibits the release of NF kappa B by blockade of a signal leading to the phosphorylation of I kappa B alpha.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cu2+") (:form . "Cu2+") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 122) (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 141)\n  (:start . 136) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x694.7.1) (:span 14 27)))\n (:hscopes ((:id . :x694.7.1) (:span 14 141)))\n (:identifiers (:sid . :s694.7) (:did . :|7488149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006443@unknown@formal@none@1@S@Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells.@(((:tag . "NNS") (:stem . "salicylate") (:form . "Salicylates") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 46) (:start . 20) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 87)\n  (:start . 81) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 108)\n  (:start . 103) (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 118)\n  (:start . 109) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s695.1) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006444@unknown@formal@none@1@S@Binding of plasma Factor VII/VIIa to the tissue factor (TF) receptor initiates the coagulation protease cascades.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "Factor") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "VII/VIIa") (:form . "VII/VIIa") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "coagulation") (:form . "coagulation") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s695.2) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006445@unknown@formal@none@1@S@TF expression by circulating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases.@(((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "thrombotic") (:form . "thrombotic") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 85)\n  (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "complication") (:form . "complications")\n  (:end . 99) (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s695.3) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006446@unknown@formal@none@1@S@Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide (LPS) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 106) (:start . 88) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 161)\n  (:start . 149) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 198)\n  (:start . 190) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s695.4) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006447@unknown@formal@none@1@S@Here, we report that a family of anti-inflammatory agents, known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 50) (:start . 33) (:id . 50))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "salicylate") (:form . "salicylates") (:end . 83)\n  (:start . 72) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 158)\n  (:start . 153) (:id . 69))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 168)\n  (:start . 159) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 188)\n  (:start . 183) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 74))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 208)\n  (:start . 198) (:id . 76))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 217)\n  (:start . 209) (:id . 77))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 223)\n  (:start . 218) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s695.5) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006448@unknown@formal@none@1@S@Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 66)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 78)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 140) (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 166)\n  (:start . 154) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s695.6) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006450@unknown@formal@none@1@S@These results indicated that salicylates inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "salicylate") (:form . "salicylates") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 144) (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 157)\n  (:start . 148) (:id . 62))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 170)\n  (:start . 158) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x695.8.1) (:span 14 28)))\n (:hscopes ((:id . :x695.8.1) (:span 14 170)))\n (:identifiers (:sid . :s695.8) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006451@unknown@formal@none@1@S@The clinical benefits of salicylates in the treatment of several diseases, including atherosclerosis and rheumatoid arthritis, may be related to their ability to reduce monocyte gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "benefit") (:form . "benefits") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "salicylate") (:form . "salicylates") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 100) (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "VB") (:stem . "reduce") (:form . "reduce") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x695.9.1) (:span 127 130)))\n (:hscopes ((:id . :x695.9.1) (:span 0 193)))\n (:identifiers (:sid . :s695.9) (:did . :|7492771|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006452@unknown@formal@none@1@S@CIITA activates the expression of MHC class II genes in mouse T cells.@(((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s696.1) (:did . :|7495759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006453@unknown@formal@none@1@S@It has long been a puzzle that MHC class II molecules are expressed in human T cells after activation but not in mouse T cells; this expression is believed to play a role in the cell mediated immune response.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "puzzle") (:form . "puzzle") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 120) (:start . 119)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 127) (:start . 126)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 132) (:start . 128)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 155)\n  (:start . 147) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 72))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 163) (:start . 159)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 74))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 170) (:start . 166)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 191)\n  (:start . 183) (:id . 79))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 198)\n  (:start . 192) (:id . 80))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 207)\n  (:start . 199) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x696.2.1) (:span 147 155)))\n (:ncues ((:id . :x696.2.2) (:span 106 109)))\n (:hscopes ((:id . :x696.2.1) (:span 128 207)))\n (:nscopes ((:id . :x696.2.2) (:span 106 126)))\n (:identifiers (:sid . :s696.2) (:did . :|7495759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006454@unknown@formal@none@1@S@Recently the MHC class II transactivator (CIITA) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 40) (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 91)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 124)\n  (:start . 112) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s696.3) (:did . :|7495759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006455@unknown@formal@none@1@S@Here we show that human T cells expressing MHC class II have CIITA transcripts while MHC class II-negative human T cells and mouse T cells do not.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 78)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ii-negative") (:form . "II-negative") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 66))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x696.4.1) (:span 142 145)))\n (:nscopes ((:id . :x696.4.1) (:span 142 145)))\n (:identifiers (:sid . :s696.4) (:did . :|7495759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006456@unknown@formal@none@1@S@The expression of MHC class II genes in mouse T cells can be reconstituted upon transfection with the human CIITA cDNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 74) (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 92)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s696.5) (:did . :|7495759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006457@unknown@formal@none@1@S@These data indicate that the expression of CIITA explains the expression or lack of expression of MHC class II in human and mouse T cells respectively.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "explain") (:form . "explains") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 150)\n  (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x696.6.2) (:span 11 24)))\n (:ncues ((:id . :x696.6.1) (:span 76 80)))\n (:hscopes ((:id . :x696.6.2) (:span 11 150)))\n (:nscopes ((:id . :x696.6.1) (:span 76 150)))\n (:identifiers (:sid . :s696.6) (:did . :|7495759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006458@unknown@formal@none@1@S@Identification of an I kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on I kappa B alpha.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "alpha-associated") (:form . "alpha-associated")\n  (:end . 47) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 134) (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s697.1) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006460@unknown@formal@none@1@S@Stimulation of cells leads to a rapid phosphorylation of I kappa B alpha, which is presumed to be important for the subsequent degradation.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "presume") (:form . "presumed") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 107)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 126)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 138)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x697.3.1) (:span 83 91)))\n (:hscopes ((:id . :x697.3.1) (:span 74 138)))\n (:identifiers (:sid . :s697.3) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006461@unknown@formal@none@1@S@We have recently reported the establishment of a lipopolysaccharide (LPS)-dependent cell-free activation system of NF-kappa B in association with the induction of I kappa B alpha phosphorylation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "establishment") (:form . "establishment")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 67) (:start . 49) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LPS)-dependent") (:form . "LPS)-dependent")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 111)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 140)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 159)\n  (:start . 150) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 172) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 194) (:start . 179) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s697.4) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006462@unknown@formal@none@1@S@In this study, we have identified a kinase in cell extracts from the LPS-stimulated human monocytic cell line, THP-1, that specifically binds and phosphorylates I kappa B alpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 33)\n  (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 83) (:start . 69) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 135)\n  (:start . 123) (:id . 65))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "phosphorylate") (:form . "phosphorylates")\n  (:end . 160) (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 162) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 170) (:start . 169)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s697.5) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006463@unknown@formal@none@1@S@LPS stimulation transiently enhanced the I kappa B alpha-bound kinase activity in THP-1 cells.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "alpha-bound") (:form . "alpha-bound") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s697.6) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006464@unknown@formal@none@1@S@Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 127) (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Thr") (:form . "Thr") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 195)\n  (:start . 185) (:id . 71))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 202)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 209)\n  (:start . 203) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 214) (:start . 213)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 220)\n  (:start . 215) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 222) (:start . 221)\n  (:id . 77))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 228)\n  (:start . 223) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s697.7) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006465@unknown@formal@none@1@S@Moreover, we show that the peptide, corresponding to the C-terminal acidic domain of I kappa B alpha, blocked the LPS-induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 49)\n  (:start . 36) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 125)\n  (:start . 114) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 168)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 184) (:start . 169) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 198)\n  (:start . 188) (:id . 74))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 206)\n  (:start . 201) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 208) (:start . 207)\n  (:id . 77))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 214)\n  (:start . 209) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 229)\n  (:start . 220) (:id . 81))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 236)\n  (:start . 230) (:id . 82))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 242) (:start . 237)\n  (:id . 83))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 248)\n  (:start . 243) (:id . 84))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 254)\n  (:start . 249) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s697.8) (:did . :|7499266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5006467@unknown@formal@none@1@S@Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.@(((:tag . "NN") (:stem . "triggering") (:form . "Triggering") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 62) (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 94)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 122)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 134)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 142)\n  (:start . 135) (:id . 59))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 153)\n  (:start . 143) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 164)\n  (:start . 154) (:id . 61))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 173)\n  (:start . 165) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 177) (:start . 175)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 183)\n  (:start . 178) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 194) (:start . 191)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 208) (:start . 195) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 216)\n  (:start . 209) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s698.1) (:did . :|7499267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006468@unknown@formal@none@1@S@We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 84) (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "FW") (:stem . "IFN-gamma)/tumor") (:form . "IFN-gamma)/tumor")\n  (:end . 102) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 124)\n  (:start . 112) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 145)\n  (:start . 140) (:id . 61))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 159) (:start . 146) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 190)\n  (:start . 181) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 210)\n  (:start . 202) (:id . 73))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 218) (:start . 214)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 76))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 228)\n  (:start . 223) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 78))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 236) (:start . 232)\n  (:id . 79))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 246)\n  (:start . 237) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 249) (:start . 247)\n  (:id . 81))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 268) (:start . 250) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 270) (:start . 269)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 273) (:start . 270)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 274) (:start . 273)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s698.2) (:did . :|7499267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006470@unknown@formal@none@1@S@The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "concern") (:form . "concerned") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "LS") (:stem . "1") (:form . 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5006472@unknown@formal@none@1@S@Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.@(((:tag . "JJ") (:stem . "synergistic") (:form . "Synergistic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 155)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 172)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 180)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 196)\n  (:start . 188) (:id . 73))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 203)\n  (:start . 197) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 76))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 225) (:start . 211) (:id . 77))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 233)\n  (:start . 226) (:id . 78))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 241)\n  (:start . 234) (:id . 79))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 249)\n  (:start . 242) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 256) (:start . 253)\n  (:id . 82))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 261) (:start . 257)\n  (:id . 83))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 270)\n  (:start . 262) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s698.6) (:did . :|7499267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006473@unknown@formal@none@1@S@This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 120) (:start . 105) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s698.7) (:did . :|7499267|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006474@unknown@formal@none@1@S@Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.@(((:tag . "NNP") (:stem . "Thrombin") (:form . "Thrombin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 124) (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD69") (:form . "CD69") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 173)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s699.1) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006475@unknown@formal@none@1@S@Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.@(((:tag . "NNP") (:stem . "Thrombin") (:form . "Thrombin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s699.2) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006476@unknown@formal@none@1@S@Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.@(((:tag . "JJ") (:stem . "proteolytic") (:form . "Proteolytic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "diisopropyl") (:form . "diisopropyl") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "fluorophosphate-thrombin")\n  (:form . "fluorophosphate-thrombin") (:end . 106) (:start . 82) (:id . 54))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 113)\n  (:start . 107) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 133)\n  (:start . 127) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x699.3.1) (:span 107 113)))\n (:nscopes ((:id . :x699.3.1) (:span 107 133)))\n (:identifiers (:sid . :s699.3) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006477@unknown@formal@none@1@S@Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hirudin") (:form . "hirudin") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "anti-thrombin") (:form . "anti-thrombin")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "thrombin-induced") (:form . "thrombin-induced")\n  (:end . 73) (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s699.4) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006478@unknown@formal@none@1@S@A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TRP") (:form . "TRP") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SFLLRNP") (:form . "SFLLRNP") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 104)\n  (:start . 95) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 116)\n  (:start . 108) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 128)\n  (:start . 122) (:id . 67))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 141)\n  (:start . 129) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 70))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 151) (:start . 147)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 160)\n  (:start . 152) (:id . 72))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 168)\n  (:start . 161) (:id . 73))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 173) (:start . 169)\n  (:id . 74))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 193)\n  (:start . 182) (:id . 76))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 198) (:start . 194)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 207)\n  (:start . 199) (:id . 78))\n ((:tag . "NNS") (:stem . "store") (:form . "stores") (:end . 214)\n  (:start . 208) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s699.5) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006480@unknown@formal@none@1@S@There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "thrombin-induced") (:form . "thrombin-induced")\n  (:end . 53) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 78) (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 107)\n  (:start . 99) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 129)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s699.7) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006481@unknown@formal@none@1@S@Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.@(((:tag . "NNP") (:stem . "Thrombin") (:form . "Thrombin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TRP") (:form . "TRP") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s699.8) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006482@unknown@formal@none@1@S@As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "nf-kb") (:form . "NF-kB") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x699.9.1) (:span 5 11)))\n (:hscopes ((:id . :x699.9.1) (:span 5 39)))\n (:identifiers (:sid . :s699.9) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006483@unknown@formal@none@1@S@Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . 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5006484@unknown@formal@none@1@S@The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "parallel") (:form . "paralleled") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s699.11) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006485@unknown@formal@none@1@S@We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 59)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 81) (:start . 63) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 204)\n  (:start . 193) (:id . 72))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 209) (:start . 205)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 75))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 225)\n  (:start . 217) (:id . 76))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 234)\n  (:start . 226) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s699.12) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006486@unknown@formal@none@1@S@Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TRP") (:form . "TRP") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "cd69") (:form . "CD69") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 184)\n  (:start . 179) (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 196)\n  (:start . 185) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s699.13) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006487@unknown@formal@none@1@S@These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "highlight") (:form . "highlight") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s699.14) (:did . :|7510689|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006488@unknown@formal@none@1@S@The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fk506-sensitive") (:form . "FK506-sensitive")\n  (:end . 88) (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 132)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s700.1) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006490@unknown@formal@none@1@S@We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 130)\n  (:start . 124) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 147)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 158)\n  (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 171)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 182)\n  (:start . 172) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 187) (:start . 184)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 76))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 200)\n  (:start . 193) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Ca2+") (:form . "Ca2+") (:end . 206) (:start . 202)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 217)\n  (:start . 208) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 82))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 228)\n  (:start . 219) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 229) (:start . 228)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s700.3) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006491@unknown@formal@none@1@S@By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 102)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 151)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s700.4) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006492@unknown@formal@none@1@S@FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.@(((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "transcription") (:form . "transcriptions")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "Ca(2+)-mobilizing") (:form . "Ca(2+)-mobilizing")\n  (:end . 112) (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "Ca(2+)-independent") (:form . "Ca(2+)-independent")\n  (:end . 164) (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x700.5.1) (:span 125 128)))\n (:nscopes ((:id . :x700.5.1) (:span 125 172)))\n (:identifiers (:sid . :s700.5) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006493@unknown@formal@none@1@S@In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pma/ionomycin-induced")\n  (:form . "PMA/ionomycin-induced") (:end . 109) (:start . 88) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 148)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "anti-jund") (:form . "anti-JunD") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 181)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s700.6) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006494@unknown@formal@none@1@S@In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EGTA") (:form . "EGTA") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ca2+") (:form . "Ca2+") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chelator") (:form . "chelator") (:end . 41)\n  (:start . 33) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 52)\n  (:start . 43) (:id . 52))\n ((:tag . "VBD") (:stem . "affect") (:form . "affected") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 159)\n  (:start . 149) (:id . 69))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 167)\n  (:start . 160) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 177)\n  (:start . 172) (:id . 72))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 188)\n  (:start . 182) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 197)\n  (:start . 189) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 204)\n  (:start . 199) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 209) (:start . 206)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 80))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 214) (:start . 211)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 83))\n ((:tag . "NN") (:stem . "p49") (:form . "p49") (:end . 223) (:start . 220)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x700.7.1) (:span 127 130)))\n (:nscopes ((:id . :x700.7.1) (:span 116 224)))\n (:identifiers (:sid . :s700.7) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006495@unknown@formal@none@1@S@Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "report") (:form . 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"which") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 182)\n  (:start . 174) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 201) (:start . 197)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 211)\n  (:start . 202) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 214) (:start . 212)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 220)\n  (:start . 215) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "indicate") (:form . 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"binding") (:end . 343)\n  (:start . 336) (:id . 98))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 351)\n  (:start . 344) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 352) (:start . 351)\n  (:id . 100)))@@@1@59@((:hcues ((:id . :x700.8.1) (:span 222 237)))\n (:hscopes ((:id . :x700.8.1) (:span 222 351)))\n (:identifiers (:sid . :s700.8) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006496@unknown@formal@none@1@S@Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NFIL-2A") (:form . "NFIL-2A") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 130)\n  (:start . 125) (:id . 67))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 137)\n  (:start . 131) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 143)\n  (:start . 138) (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 147) (:start . 144)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "terminal") (:form . "terminals") (:end . 157)\n  (:start . 148) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "fk506-sensitive") (:form . "FK506-sensitive")\n  (:end . 176) (:start . 161) (:id . 73))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 184)\n  (:start . 177) (:id . 74))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 194)\n  (:start . 185) (:id . 75))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 199) (:start . 195)\n  (:id . 76))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 212)\n  (:start . 200) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x700.9.1) (:span 12 25)))\n (:hscopes ((:id . :x700.9.1) (:span 12 212)))\n (:identifiers (:sid . :s700.9) (:did . :|7510691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006497@unknown@formal@none@1@S@Sp1 is a critical factor for the monocytic specific expression of human CD14.@(((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s701.1) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006498@unknown@formal@none@1@S@CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.@(((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 172) (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s701.2) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006500@unknown@formal@none@1@S@A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "5.5-kilobase") (:form . "5.5-kilobase") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4.2") (:form . "4.2") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "5'-upstream") (:form . "5'-upstream") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s701.4) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006501@unknown@formal@none@1@S@One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "CD") (:stem . "101") (:form . "101") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "CD") (:stem . "130") (:form . "130") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 115)\n  (:start . 103) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 133)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 145)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 151)\n  (:start . 146) (:id . 68))\n ((:tag . "NNP") (:stem . "ATG") (:form . "ATG") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s701.5) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006502@unknown@formal@none@1@S@A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "CD") (:stem . "128") (:form . "128") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocyte-specific") (:form . "monocyte-specific")\n  (:end . 83) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nonmonocytic") (:form . "nonmonocytic") (:end . 185)\n  (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 201) (:start . 197)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "REX") (:form . "REX") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s701.6) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006503@unknown@formal@none@1@S@Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s701.7) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006504@unknown@formal@none@1@S@The Sp1 transcription factor bound to three different regions in the CD14 promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s701.8) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006505@unknown@formal@none@1@S@Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-110") (:form . "-110") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 58)\n  (:start . 49) (:id . 53))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 74) (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 142) (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 167)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 193)\n  (:start . 185) (:id . 72))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 198) (:start . 194)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 221) (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 232)\n  (:start . 222) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 240) (:start . 236)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 243) (:start . 241)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 253)\n  (:start . 244) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 259)\n  (:start . 254) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s701.9) (:did . :|7512565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006506@unknown@formal@none@1@S@CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.@(((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 30) (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 51) (:start . 37) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . 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5006507@unknown@formal@none@1@S@Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.@(((:tag . "NN") (:stem . "tolerance") (:form . "Tolerance") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 31) (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 53)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 64)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 77) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "predominance") (:form . "predominance") (:end . 97)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s702.1) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006508@unknown@formal@none@1@S@Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of cytokines like tumor necrosis factor (TNF).@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 79) (:start . 61) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s702.2) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006510@unknown@formal@none@1@S@In nuclear run-on analysis, such tolerant cells show only a low degree of transcription, indicating that tolerance operates at or upstream of the transcription level.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "VBZ") (:stem . "operate") (:form . "operates") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 159) (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x702.4.1) (:span 127 129))\n  ((:id . :x702.4.2) (:span 89 104)))\n (:hscopes ((:id . :x702.4.1) (:span 124 141))\n  ((:id . :x702.4.2) (:span 89 165)))\n (:identifiers (:sid . :s702.4) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006511@unknown@formal@none@1@S@The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells, and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B (NF-kappa B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . 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5006512@unknown@formal@none@1@S@Resolution of the NF-kappa B complex in gel shift analysis shows that the binding protein, mobilized in naive Mono Mac 6 cells, consists mainly of p50-p65 heterodimers, while in tolerant cells, the p50 homodimer is predominant.@(((:tag . "NNP") (:stem . "Resolution") (:form . "Resolution") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mobilize") (:form . "mobilized") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 167)\n  (:start . 155) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 71))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 174)\n  (:start . 169) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 186)\n  (:start . 178) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 192)\n  (:start . 187) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 201) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 211)\n  (:start . 202) (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 214) (:start . 212)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 226)\n  (:start . 215) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s702.6) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006513@unknown@formal@none@1@S@This increase in p50 homodimers coincides with an increase in p105 mRNA, suggestive of a transcriptional up-regulation of p50.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "coincide") (:form . "coincides") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "suggestive") (:form . "suggestive") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 104) (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 118) (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x702.7.1) (:span 73 83)))\n (:hscopes ((:id . :x702.7.1) (:span 73 125)))\n (:identifiers (:sid . :s702.7) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006514@unknown@formal@none@1@S@Reporter gene analysis reveals that the NF-kappa B complex mobilized in tolerant cells is functionally inactive in that NF-kappa B-dependent luciferase constructs containing the human immunodeficiency virus long terminal repeat or the TNF 5'-region show only minimal transactivation after LPS stimulation.@(((:tag . "NN") (:stem . "reporter") (:form . "Reporter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "mobilize") (:form . "mobilized") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 173)\n  (:start . 163) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 183)\n  (:start . 178) (:id . 66))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 200) (:start . 184) (:id . 67))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 206)\n  (:start . 201) (:id . 68))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 211) (:start . 207)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 220)\n  (:start . 212) (:id . 70))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 227)\n  (:start . 221) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 230) (:start . 228)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 238) (:start . 235)\n  (:id . 74))\n ((:tag . "NN") (:stem . "5'-region") (:form . "5'-region") (:end . 248)\n  (:start . 239) (:id . 75))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 253) (:start . 249)\n  (:id . 76))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 258) (:start . 254)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 266)\n  (:start . 259) (:id . 78))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 282) (:start . 267) (:id . 79))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 288)\n  (:start . 283) (:id . 80))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 292) (:start . 289)\n  (:id . 81))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 304)\n  (:start . 293) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s702.8) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006515@unknown@formal@none@1@S@Similar to Mono Mac 6 cells, primary blood monocytes, when precultured with a low dose of LPS, also become tolerant and produce little TNF after LPS stimulation.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "preculture") (:form . "precultured") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 99) (:start . 95)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 106)\n  (:start . 100) (:id . 63))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 115)\n  (:start . 107) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 127)\n  (:start . 120) (:id . 66))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 134)\n  (:start . 128) (:id . 67))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 138) (:start . 135)\n  (:id . 68))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 144)\n  (:start . 139) (:id . 69))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 148) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 160)\n  (:start . 149) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s702.9) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006516@unknown@formal@none@1@S@The tolerant blood monocytes also up-regulate CD14, and they mobilize NF-kappa B with a predominance of p50 homodimers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "up-regulate") (:form . "up-regulate") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "mobilize") (:form . "mobilize") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "predominance") (:form . "predominance") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s702.10) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006517@unknown@formal@none@1@S@Taken together, these results demonstrate that tolerance to LPS is determined by post-receptor mechanisms that involve an altered composition of the NF-kappa B complex.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "post-receptor") (:form . "post-receptor")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 141)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 167)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s702.11) (:did . :|7516328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006518@unknown@formal@none@1@S@Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.@(((:tag . "NNP") (:stem . "Alpha-tocopherol") (:form . "Alpha-tocopherol")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 25)\n  (:start . 17) (:id . 43))\n ((:tag . "JJ") (:stem . "agonist-induced") (:form . "agonist-induced")\n  (:end . 41) (:start . 26) (:id . 44))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 51)\n  (:start . 42) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 65)\n  (:start . 57) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 77)\n  (:start . 69) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 95)\n  (:start . 84) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s703.1) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006520@unknown@formal@none@1@S@We have examined the effect of alpha-tocopherol (alpha-tcp) on one cellular event in atherosclerotic plaque development, monocyte adhesion to stimulated endothelial cells (ECs).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . "alpha-tocopherol")\n  (:end . 47) (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 100) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "plaque") (:form . "plaque") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 164)\n  (:start . 153) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "EC") (:form . "ECs") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s703.3) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006521@unknown@formal@none@1@S@Human umbilical vein ECs were pretreated with alpha-tcp before stimulation with known agonists of monocyte adhesion: IL-1 (10 ng/ml), LPS (10 ng/ml), thrombin (30 U/ml), or PMA (10 nM).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 147)\n  (:start . 142) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "thrombin") (:form . "thrombin") (:end . 158)\n  (:start . 150) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 72))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 162) (:start . 160)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 167) (:start . 163)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 172) (:start . 170)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 176) (:start . 173)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 79))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 180) (:start . 178)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 183) (:start . 181)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s703.4) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006522@unknown@formal@none@1@S@Agonist-induced monocytic cell adhesion, but not basal adhesion, was inhibited in a time- and concentration-dependent manner by alpha-tcp.@(((:tag . "JJ") (:stem . "agonist-induced") (:form . "Agonist-induced")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 25)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 30) (:start . 26)\n  (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "time-") (:form . "time-") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 117) (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x703.5.1) (:span 45 48)))\n (:nscopes ((:id . :x703.5.1) (:span 45 63)))\n (:identifiers (:sid . :s703.5) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006523@unknown@formal@none@1@S@The IC50 of alpha-tcp on an IL-1-induced response was 45 microM.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ic50") (:form . "IC50") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s703.6) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006524@unknown@formal@none@1@S@The inhibition correlated with a decrease in steady state levels of E-selectin mRNA and cell surface expression of E-selectin which is consistent with the ability of a monoclonal antibody to E-selectin to inhibit monocytic cell adhesion in this system.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 201)\n  (:start . 191) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 212)\n  (:start . 205) (:id . 74))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 222)\n  (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 227) (:start . 223)\n  (:id . 76))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 236)\n  (:start . 228) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 239) (:start . 237)\n  (:id . 78))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 244) (:start . 240)\n  (:id . 79))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 251)\n  (:start . 245) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s703.7) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006525@unknown@formal@none@1@S@Probucol (50 microM) and N-acetylcysteine (20 mM) also inhibited agonist-induced monocytic cell adhesion; whereas, several other antioxidants had no significant effect.@(((:tag . "NNP") (:stem . "Probucol") (:form . "Probucol") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 41) (:start . 25) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 64)\n  (:start . 55) (:id . 54))\n ((:tag . "JJ") (:stem . "agonist-induced") (:form . "agonist-induced")\n  (:end . 80) (:start . 65) (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 141)\n  (:start . 129) (:id . 64))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 160)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x703.8.1) (:span 146 148)))\n (:nscopes ((:id . :x703.8.1) (:span 146 167)))\n (:identifiers (:sid . :s703.8) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006526@unknown@formal@none@1@S@Protein kinase C (PKC) does not appear to play a role in the alpha-tcp effect since no suppression of phosphorylation of PKC substrates was observed.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 38)\n  (:start . 32) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 53) (:start . 49)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 70)\n  (:start . 61) (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 77)\n  (:start . 71) (:id . 58))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 83) (:start . 78)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 98)\n  (:start . 87) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 117) (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 135)\n  (:start . 125) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 148)\n  (:start . 140) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x703.9.3) (:span 32 38)))\n (:ncues ((:id . :x703.9.1) (:span 84 86)) ((:id . :x703.9.2) (:span 28 31)))\n (:hscopes ((:id . :x703.9.3) (:span 0 77)))\n (:nscopes ((:id . :x703.9.1) (:span 84 148))\n  ((:id . :x703.9.2) (:span 0 77)))\n (:identifiers (:sid . :s703.9) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006527@unknown@formal@none@1@S@Activation of the transcription factor NF-kappa B is reported to be necessary but not sufficient for E-selectin expression in EC.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x703.10.1) (:span 82 85)))\n (:nscopes ((:id . :x703.10.1) (:span 82 128)))\n (:identifiers (:sid . :s703.10) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006528@unknown@formal@none@1@S@Electrophoretic mobility shift assays failed to show an alpha-tcp-induced decrease in activation of this transcription factor after cytokine stimulation.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 44) (:start . 38)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "alpha-tcp-induced") (:form . "alpha-tcp-induced")\n  (:end . 73) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 131)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 140)\n  (:start . 132) (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 152)\n  (:start . 141) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x703.11.1) (:span 38 44)))\n (:nscopes ((:id . :x703.11.1) (:span 38 152)))\n (:identifiers (:sid . :s703.11) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006530@unknown@formal@none@1@S@Our results point to a novel alternative mechanism of action of alpha-tcp.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "point") (:form . "point") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha-tcp") (:form . "alpha-tcp") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s703.13) (:did . :|7518838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006531@unknown@formal@none@1@S@Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers.@(((:tag . "NN") (:stem . "upregulation") (:form . "Upregulation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 95) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 171)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 187)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 195)\n  (:start . 188) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s704.1) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006532@unknown@formal@none@1@S@An ability of the Epstein-Barr virus latent membrane protein LMP1 to enhance the survival of infected B cells through upregulation of the bcl-2 oncogene was first suggested by experiments involving gene transfection and the selection of stable LMP1+ clones (S.Henderson, M. Rowe, C.Gregory, F.Wang, E.Kieff, and A.Rickinson, Cell 65:1107-1115, 1991).@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latent") (:form . 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5006533@unknown@formal@none@1@S@However, it was not possible to ascertain whether Bcl-2 upregulation was a specific consequence of LMP1 expression or an artifact of the selection procedure whereby rare Bcl-2+ cells already present in the starting population might best be able to tolerate the potentially toxic effects of LMP1.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . 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"be") (:end . 239) (:start . 237)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 244) (:start . 240)\n  (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 247) (:start . 245)\n  (:id . 81))\n ((:tag . "VB") (:stem . "tolerate") (:form . "tolerate") (:end . 256)\n  (:start . 248) (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 260) (:start . 257)\n  (:id . 83))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 272)\n  (:start . 261) (:id . 84))\n ((:tag . "JJ") (:stem . "toxic") (:form . "toxic") (:end . 278)\n  (:start . 273) (:id . 85))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 286)\n  (:start . 279) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 289) (:start . 287)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 294) (:start . 290)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x704.3.1) (:span 261 272))\n  ((:id . :x704.3.2) (:span 226 231)) ((:id . :x704.3.3) (:span 115 117))\n  ((:id . :x704.3.4) (:span 42 49)) ((:id . :x704.3.5) (:span 16 41)))\n (:hscopes ((:id . :x704.3.1) (:span 261 294))\n  ((:id . :x704.3.2) (:span 226 294)) ((:id . :x704.3.3) (:span 73 294))\n  ((:id . :x704.3.4) (:span 42 294)) ((:id . :x704.3.5) (:span 16 294)))\n (:identifiers (:sid . :s704.3) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006534@unknown@formal@none@1@S@We therefore reexamined this issue by using two different experimental approaches that allowed LMP1- induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures; activation of the NF-kappa B transcription factor and upregulation of the cell adhesion molecule ICAM-1 were used as early indices of LMP1 function.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "reexamine") (:form . "reexamined") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "lmp1-") (:form . "LMP1-") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "monitor") (:form . "monitored") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 178)\n  (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 186)\n  (:start . 179) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . 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"the") (:end . 247) (:start . 244)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 256)\n  (:start . 248) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 258) (:start . 257)\n  (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 272) (:start . 259) (:id . 81))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 279)\n  (:start . 273) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 283) (:start . 280)\n  (:id . 83))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 296)\n  (:start . 284) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 299) (:start . 297)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 303) (:start . 300)\n  (:id . 86))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 308) (:start . 304)\n  (:id . 87))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 317)\n  (:start . 309) (:id . 88))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 326)\n  (:start . 318) (:id . 89))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 333)\n  (:start . 327) (:id . 90))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 338) (:start . 334)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 343) (:start . 339)\n  (:id . 92))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 346) (:start . 344)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 352)\n  (:start . 347) (:id . 94))\n ((:tag . "NNS") (:stem . "index") (:form . "indices") (:end . 360)\n  (:start . 353) (:id . 95))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 363) (:start . 361)\n  (:id . 96))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 368) (:start . 364)\n  (:id . 97))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 377)\n  (:start . 369) (:id . 98))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 378) (:start . 377)\n  (:id . 99)))@@@1@58@((:ncues ((:id . :x704.4.1) (:span 198 205)))\n (:nscopes ((:id . :x704.4.1) (:span 198 228)))\n (:identifiers (:sid . :s704.4) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006535@unknown@formal@none@1@S@In the first approach, stable clones of two B-cell lines carrying an LMP1 gene under the control of an inducible metallothionein promoter were induced to express LMP1 in all cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 96)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 112)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "metallothionein") (:form . "metallothionein")\n  (:end . 128) (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s704.5) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006536@unknown@formal@none@1@S@Activation of NK-kappa B and upregulation of ICAM-1 occurred within 24 h and were followed at 48 to 72 h by upregulation of Bcl-2.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NK-kappa") (:form . "NK-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 120)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s704.6) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006537@unknown@formal@none@1@S@In the second approach, we tested the generality of this phenomenon by transiently expressing LMP1 from a strong constitutively active promoter in a range of different cell types.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 33) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "generality") (:form . "generality") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 127) (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s704.7) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006538@unknown@formal@none@1@S@All six B-cell lines tested showed NF-kappa B activation in response to LMP1 expression, and this was followed in five of six lines by expression of ICAM-1 and Bcl-2.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 27) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 34) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 155)\n  (:start . 149) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 165)\n  (:start . 160) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s704.8) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006540@unknown@formal@none@1@S@We therefore conclude that Bcl-2 upregulation is part of the panoply of cellular changes induced by LMP1 but that the effect is cell type specific.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "panoply") (:form . "panoply") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s704.10) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006541@unknown@formal@none@1@S@Our data also suggest that whilst NF-kappa B may be an essential component of LMP1 signal transduction, other cell-specific factors may be required to effect some functions of the viral protein.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "whilst") (:form . "whilst") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 102)\n  (:start . 90) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 123) (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "VB") (:stem . "effect") (:form . "effect") (:end . 157)\n  (:start . 151) (:id . 67))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 193)\n  (:start . 186) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x704.11.1) (:span 132 135))\n  ((:id . :x704.11.2) (:span 45 48)) ((:id . :x704.11.3) (:span 14 21)))\n (:hscopes ((:id . :x704.11.1) (:span 132 193))\n  ((:id . :x704.11.2) (:span 45 102)) ((:id . :x704.11.3) (:span 14 193)))\n (:identifiers (:sid . :s704.11) (:did . :|7520093|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006542@unknown@formal@none@1@S@CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.@(((:tag . "JJ") (:stem . "cd14-mediated") (:form . "CD14-mediated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 27) (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 51)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 83) (:start . 65) (:id . 50))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 88) (:start . 84)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 100)\n  (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 116)\n  (:start . 110) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x705.1.1) (:span 89 92)))\n (:nscopes ((:id . :x705.1.1) (:span 89 125)))\n (:identifiers (:sid . :s705.1) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006543@unknown@formal@none@1@S@During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "serious") (:form . "serious") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 69) (:start . 51) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 154)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 170)\n  (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 193)\n  (:start . 185) (:id . 70))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 202)\n  (:start . 194) (:id . 71))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 212)\n  (:start . 203) (:id . 72))\n ((:tag . "JJ") (:stem . "hemodynamic") (:form . "hemodynamic") (:end . 224)\n  (:start . 213) (:id . 73))\n ((:tag . "NN") (:stem . "instability") (:form . "instability") (:end . 236)\n  (:start . 225) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 75))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 246)\n  (:start . 241) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x705.2.1) (:span 79 87)))\n (:hscopes ((:id . :x705.2.1) (:span 51 246)))\n (:identifiers (:sid . :s705.2) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006544@unknown@formal@none@1@S@CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.@(((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "glycosylphosphatidylinositol-linked")\n  (:form . "glycosylphosphatidylinositol-linked") (:end . 43) (:start . 8)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 51)\n  (:start . 44) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s705.3) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006545@unknown@formal@none@1@S@A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "concern") (:form . "concerns") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 81) (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "transduce") (:form . "transduces") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x705.4.1) (:span 65 67)))\n (:nscopes ((:id . :x705.4.1) (:span 65 88)))\n (:identifiers (:sid . :s705.4) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006546@unknown@formal@none@1@S@Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "investigator") (:form . "investigators")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "hypothesize") (:form . "hypothesized") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd14-mediated") (:form . "CD14-mediated")\n  (:end . 60) (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "effect") (:form . "effected") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 112) (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 121)\n  (:start . 113) (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 128)\n  (:start . 122) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TK") (:form . "TK") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 145)\n  (:start . 135) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "multicomponent") (:form . "multicomponent")\n  (:end . 162) (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 171)\n  (:start . 163) (:id . 64))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 177)\n  (:start . 172) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 184) (:start . 181)\n  (:id . 67))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 194)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x705.5.1) (:span 135 145))\n  ((:id . :x705.5.2) (:span 29 41)))\n (:hscopes ((:id . :x705.5.1) (:span 135 194))\n  ((:id . :x705.5.2) (:span 29 194)))\n (:identifiers (:sid . :s705.5) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006547@unknown@formal@none@1@S@Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).@(((:tag . "JJ") (:stem . "wild-type") (:form . "Wild-type") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "chinese") (:form . "Chinese") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "hamster") (:form . "hamster") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "ovary") (:form . "ovary") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "CHO)-K1") (:form . "CHO)-K1") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "arachidonate") (:form . "arachidonate") (:end . 100)\n  (:start . 88) (:id . 56))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 123)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cho/cd14") (:form . "CHO/CD14") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s705.6) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006548@unknown@formal@none@1@S@Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lps-inducible") (:form . "LPS-inducible")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s705.7) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006550@unknown@formal@none@1@S@LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.@(((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 28) (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cho/cd14") (:form . "CHO/CD14") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "resemble") (:form . "resembled") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 102)\n  (:start . 96) (:id . 56))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 118) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 138)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s705.9) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006551@unknown@formal@none@1@S@Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 48) (:start . 33) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "arachidonate") (:form . "arachidonate") (:end . 77)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 85)\n  (:start . 78) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 103)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 122) (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 132)\n  (:start . 123) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 147)\n  (:start . 141) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 164) (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 176)\n  (:start . 168) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 178) (:start . 177)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cho/cd14") (:form . "CHO/CD14") (:end . 190)\n  (:start . 182) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 193) (:start . 191)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 203)\n  (:start . 198) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 209)\n  (:start . 204) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 224) (:start . 211) (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 229) (:start . 225)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 238)\n  (:start . 230) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 240) (:start . 239)\n  (:id . 77))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 254) (:start . 241) (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 257) (:start . 255)\n  (:id . 79))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 260) (:start . 258)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 266)\n  (:start . 261) (:id . 81))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 272)\n  (:start . 267) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x705.10.1) (:span 138 140)))\n (:nscopes ((:id . :x705.10.1) (:span 138 209)))\n (:identifiers (:sid . :s705.10) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006552@unknown@formal@none@1@S@Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TK") (:form . "TK") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "immunoblotte") (:form . "immunoblotting")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 117)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "phosphotyrosine") (:form . "phosphotyrosine")\n  (:end . 133) (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 142)\n  (:start . 134) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 151) (:start . 148)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 160)\n  (:start . 152) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 165) (:start . 161)\n  (:id . 63))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 175)\n  (:start . 166) (:id . 64))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 183)\n  (:start . 176) (:id . 65))\n ((:tag . "NN") (:stem . "cho/cd14") (:form . "CHO/CD14") (:end . 192)\n  (:start . 184) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 198)\n  (:start . 193) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x705.11.1) (:span 148 151)))\n (:nscopes ((:id . :x705.11.1) (:span 148 198)))\n (:identifiers (:sid . :s705.11) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006553@unknown@formal@none@1@S@Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TK") (:form . "TK") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 64) (:start . 58)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cho/cd14") (:form . "CHO/CD14") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 165)\n  (:start . 159) (:id . 69))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 175)\n  (:start . 166) (:id . 70))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 187)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "TK") (:form . "TK") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 199)\n  (:start . 191) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "RAW") (:form . "RAW") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "CD") (:stem . "264.7") (:form . "264.7") (:end . 212)\n  (:start . 207) (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x705.12.1) (:span 58 64)))\n (:nscopes ((:id . :x705.12.1) (:span 58 134)))\n (:identifiers (:sid . :s705.12) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006554@unknown@formal@none@1@S@These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TK") (:form . "TK") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd14-mediated") (:form . "CD14-mediated")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 92)\n  (:start . 80) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x705.13.2) (:span 14 19)))\n (:ncues ((:id . :x705.13.1) (:span 40 43)))\n (:hscopes ((:id . :x705.13.2) (:span 14 120)))\n (:nscopes ((:id . :x705.13.1) (:span 40 120)))\n (:identifiers (:sid . :s705.13) (:did . :|7520914|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006555@unknown@formal@none@1@S@Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 62) (:start . 47) (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 70)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha,25-dihydroxyvitamin")\n  (:form . "alpha,25-dihydroxyvitamin") (:end . 103) (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 106) (:start . 104)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s706.1) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006556@unknown@formal@none@1@S@CD14, a monocyte/macrophage receptor for the complex of LPS and LPS binding protein, is a differentiation marker for the monocyte/macrophage lineage.@(((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 27) (:start . 8) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 105) (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 140) (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s706.2) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006557@unknown@formal@none@1@S@We have analyzed the regulation of CD14 expression during 1 alpha,25-dihydroxyvitamin D3 (VitD3)-induced monocytic differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha,25-dihydroxyvitamin")\n  (:form . "alpha,25-dihydroxyvitamin") (:end . 85) (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "VitD3)-induced") (:form . "VitD3)-induced")\n  (:end . 104) (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 130) (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s706.3) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006558@unknown@formal@none@1@S@Using FACS, Northern blotting, and nuclear run-on analyses, we demonstrate that the up-regulation of CD14 expression during monocytic cell maturation is regulated mainly at the level of gene transcription, and that new protein synthesis is required for CD14 induction.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "facs") (:form . "FACS") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 97) (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 162)\n  (:start . 153) (:id . 66))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 204) (:start . 191) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 75))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 218) (:start . 215)\n  (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 226)\n  (:start . 219) (:id . 78))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 236)\n  (:start . 227) (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 239) (:start . 237)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 248)\n  (:start . 240) (:id . 81))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 252) (:start . 249)\n  (:id . 82))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 257) (:start . 253)\n  (:id . 83))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 267)\n  (:start . 258) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s706.4) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006560@unknown@formal@none@1@S@Using stable transfection of the monocytoid U937 cell line with a series of deletion mutants of the CD14 5' upstream sequence coupled to a reporter gene construct, we show that bp -128 to -70 is the critical region for the induction of CD14 expression.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 162)\n  (:start . 153) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 176) (:start . 172)\n  (:id . 73))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 179) (:start . 177)\n  (:id . 74))\n ((:tag . "CD") (:stem . "-128") (:form . "-128") (:end . 184) (:start . 180)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 76))\n ((:tag . "CD") (:stem . "-70") (:form . "-70") (:end . 191) (:start . 188)\n  (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 194) (:start . 192)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 207)\n  (:start . 199) (:id . 80))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 214)\n  (:start . 208) (:id . 81))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 218) (:start . 215)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 83))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 232)\n  (:start . 223) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 85))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 240) (:start . 236)\n  (:id . 86))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 251)\n  (:start . 241) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s706.6) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006561@unknown@formal@none@1@S@This region contains two binding sites for the Sp1 transcription factor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s706.7) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006562@unknown@formal@none@1@S@A 3-bp mutation at the distal Sp1-binding site not only eliminates Sp1 interaction, but also abolishes most of the VitD3 induction of CD14 expression.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "3-bp") (:form . "3-bp") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "sp1-binding") (:form . "Sp1-binding") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "eliminate") (:form . "eliminates") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s706.8) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006563@unknown@formal@none@1@S@Electrophoretic mobility shift analysis does not detect a direct interaction of the CD14 distal Sp1-binding site with the vitamin D3 receptor and its partner, the retinoid X receptor.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "sp1-binding") (:form . "Sp1-binding") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "retinoid") (:form . "retinoid") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 182)\n  (:start . 174) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x706.9.1) (:span 45 48)))\n (:nscopes ((:id . :x706.9.1) (:span 45 182)))\n (:identifiers (:sid . :s706.9) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006564@unknown@formal@none@1@S@These data demonstrate that VitD3 induces CD14 indirectly through some intermediary factor, and suggest a critical role for Sp1 in this process.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "vitd3") (:form . "VitD3") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "intermediary") (:form . "intermediary") (:end . 83)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x706.10.1) (:span 96 103)))\n (:hscopes ((:id . :x706.10.1) (:span 96 143)))\n (:identifiers (:sid . :s706.10) (:did . :|7522257|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006565@unknown@formal@none@1@S@Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.@(((:tag . "NN") (:stem . "calcium") (:form . "Calcium") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s707.1) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006566@unknown@formal@none@1@S@The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immunosuppressant") (:form . "immunosuppressant")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 38)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 40) (:start . 39)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 67) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s707.2) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006567@unknown@formal@none@1@S@When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "inactivate") (:form . "inactivates") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s707.3) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006568@unknown@formal@none@1@S@To identify potential cellular homologues of cyclosporin A that might regulate calcium signalling, we have cloned human genes encoding cyclophilin B-binding-proteins using the yeast two-hybrid system.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "homologue") (:form . "homologues") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 146)\n  (:start . 135) (:id . 62))\n ((:tag . "NNPS") (:stem . "B-binding-protein") (:form . "B-binding-proteins")\n  (:end . 165) (:start . 147) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 171) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 65))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 181)\n  (:start . 176) (:id . 66))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 192)\n  (:start . 182) (:id . 67))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 199)\n  (:start . 193) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x707.4.1) (:span 64 69)) ((:id . :x707.4.2) (:span 12 21)))\n (:hscopes ((:id . :x707.4.1) (:span 64 97))\n  ((:id . :x707.4.2) (:span 12 97)))\n (:identifiers (:sid . :s707.4) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006570@unknown@formal@none@1@S@This protein, termed calcium-signal modulating cyclophilin ligand (CAML), acts downstream of the TCR and upstream of calcineurin by causing an influx of calcium.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 20) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "calcium-signal") (:form . "calcium-signal")\n  (:end . 35) (:start . 21) (:id . 46))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 58)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 149)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s707.6) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006571@unknown@formal@none@1@S@CAML appears to be a new participant in the calcium-signal transduction pathway, implicating cyclophilin B in calcium signalling, even in the absence of cyclosporin.@(((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "participant") (:form . "participant") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "calcium-signal") (:form . "calcium-signal")\n  (:end . 58) (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 164)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x707.7.2) (:span 5 12)))\n (:ncues ((:id . :x707.7.1) (:span 142 149)))\n (:hscopes ((:id . :x707.7.2) (:span 0 79)))\n (:nscopes ((:id . :x707.7.1) (:span 142 164)))\n (:identifiers (:sid . :s707.7) (:did . :|7522304|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006572@unknown@formal@none@1@S@Inducible binding to the c-fos serum response element during T cell activation is regulated by a phosphotyrosine-containing protein.@(((:tag . "JJ") (:stem . "inducible") (:form . "Inducible") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "phosphotyrosine-containing")\n  (:form . "phosphotyrosine-containing") (:end . 123) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s708.1) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006573@unknown@formal@none@1@S@The proto-oncogene c-fos is an immediate-early gene, and one of the first genes transcribed after stimulation of most cells with a variety of ligands.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s708.2) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006574@unknown@formal@none@1@S@Fos expression may be a pivotal event in converting ligand-receptor interactions at the membrane into functional modulation of cell phenotype.@(((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "convert") (:form . "converting") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "ligand-receptor") (:form . "ligand-receptor")\n  (:end . 67) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 80)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 141)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x708.3.1) (:span 15 18)))\n (:hscopes ((:id . :x708.3.1) (:span 15 141)))\n (:identifiers (:sid . :s708.3) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006575@unknown@formal@none@1@S@The serum response element (SRE) in the c-fos regulatory region participates in induction of transcription by various growth factors and by phorbol esters and subsequent squelching of transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 56)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 76)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "squelching") (:form . "squelching") (:end . 180)\n  (:start . 170) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 197) (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s708.4) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006576@unknown@formal@none@1@S@We show that an inducible protein complex (Band A) binds to SRE DNA within 10 min after mitogenic stimulation of human PBL-T, and becomes nondetectable by 60 min.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Band") (:form . "Band") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sre") (:form . "SRE") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 74)\n  (:start . 68) (:id . 57))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 77) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 87) (:start . 82)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 97)\n  (:start . 88) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 109)\n  (:start . 98) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "NN") (:stem . "pbl-t") (:form . "PBL-T") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 137)\n  (:start . 130) (:id . 68))\n ((:tag . "JJ") (:stem . "nondetectable") (:form . "nondetectable")\n  (:end . 151) (:start . 138) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 157) (:start . 155)\n  (:id . 71))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 161) (:start . 158)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s708.5) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006577@unknown@formal@none@1@S@Band A contains the serum response factor plus additional factor(s).@(((:tag . "NNP") (:stem . "Band") (:form . "Band") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "factor(s)") (:form . "factor(s)") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s708.6) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006578@unknown@formal@none@1@S@A protein that is phosphorylated on a tyrosine residue in resting PBL-T suppresses binding of a component of Band A to the SRE motif.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "PBL-T") (:form . "PBL-T") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Band") (:form . "Band") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s708.7) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006580@unknown@formal@none@1@S@The phosphorylated tyrosine residue itself is important for the protein-protein interaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 42)\n  (:start . 36) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 79) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s708.9) (:did . :|7523507|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006581@unknown@formal@none@1@S@Steel factor affects SCL expression during normal erythroid differentiation.@(((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "scl") (:form . "SCL") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 75) (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s709.1) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006582@unknown@formal@none@1@S@Steel factor is one of the growth factors that controls the proliferation and differentiation of hematopoietic cells and SCL, also known as Tcl-5 or Tal-1, is a transcription factor involved in erythropoiesis.@(((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 110) (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Tcl-5") (:form . "Tcl-5") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Tal-1") (:form . "Tal-1") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 174) (:start . 161) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 181)\n  (:start . 175) (:id . 72))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 190)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 74))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 208) (:start . 194) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s709.2) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006583@unknown@formal@none@1@S@In this report, we studied the role of SCL in the proliferation of human peripheral blood burst-forming unit-erythroid (BFU-E) and the effects of Steel factor on SCL expression in proliferating erythroid cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 63) (:start . 50) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 83)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "burst-forming") (:form . "burst-forming")\n  (:end . 103) (:start . 90) (:id . 59))\n ((:tag . "JJ") (:stem . "unit-erythroid") (:form . "unit-erythroid")\n  (:end . 118) (:start . 104) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "BFU-E") (:form . "BFU-E") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 151)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 158)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 176)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "proliferate") (:form . "proliferating")\n  (:end . 193) (:start . 180) (:id . 74))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 203)\n  (:start . 194) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 209)\n  (:start . 204) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s709.3) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006584@unknown@formal@none@1@S@BFU-E-derived colonies increase progressively in size, as determined by cell number, from day 7 to day 14 of culture, with the greatest increase in colony size (10-fold expansion) occurring between day 7 and day 10.@(((:tag . "JJ") (:stem . "bfu-e-derived") (:form . "BFU-E-derived")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "RB") (:stem . "progressively") (:form . "progressively")\n  (:end . 45) (:start . 32) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 53) (:start . 49)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "JJS") (:stem . "great") (:form . "greatest") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 154)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 159) (:start . 155)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "10-fold") (:form . "10-fold") (:end . 168)\n  (:start . 161) (:id . 72))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 178)\n  (:start . 169) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 189)\n  (:start . 180) (:id . 75))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 197)\n  (:start . 190) (:id . 76))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 201) (:start . 198)\n  (:id . 77))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 203) (:start . 202)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 79))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 211) (:start . 208)\n  (:id . 80))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 214) (:start . 212)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s709.4) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006585@unknown@formal@none@1@S@SCL protein levels in BFU-E-derived cells were highest in day 7 cells and decreased progressively from day 7 to day 14 of culture, suggesting an association of SCL with erythroid proliferation.@(((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "bfu-e-derived") (:form . "BFU-E-derived")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "RB") (:stem . "progressively") (:form . "progressively")\n  (:end . 97) (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 156)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 192) (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x709.5.1) (:span 131 141)))\n (:hscopes ((:id . :x709.5.1) (:span 131 192)))\n (:identifiers (:sid . :s709.5) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006586@unknown@formal@none@1@S@In contrast, SCL mRNA levels did not decrease significantly between day 7 and day 14 cells, suggesting that posttranscriptional mechanisms are largely responsible for the decrease in SCL protein observed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 59) (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 102)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 127) (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 138)\n  (:start . 128) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 162)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 179)\n  (:start . 171) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 194)\n  (:start . 187) (:id . 72))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 203)\n  (:start . 195) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x709.6.1) (:span 92 102)))\n (:ncues ((:id . :x709.6.2) (:span 33 36)))\n (:hscopes ((:id . :x709.6.1) (:span 92 203)))\n (:nscopes ((:id . :x709.6.2) (:span 33 90)))\n (:identifiers (:sid . :s709.6) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006587@unknown@formal@none@1@S@The role of SCL in Steel factor-induced erythroid proliferation was then examined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "factor-induced") (:form . "factor-induced")\n  (:end . 39) (:start . 25) (:id . 48))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s709.7) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006588@unknown@formal@none@1@S@In BFU-E-derived colonies cultured with Steel factor, colony size was significantly increased compared to control.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "bfu-e-derived") (:form . "BFU-E-derived")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s709.8) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006590@unknown@formal@none@1@S@The increase in SCL protein levels in early erythroid precursors stimulated with Steel factor suggests one mechanism through which Steel factor may enhance normal erythroid proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 162)\n  (:start . 156) (:id . 65))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 186) (:start . 173) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x709.10.1) (:span 144 147))\n  ((:id . :x709.10.2) (:span 94 102)))\n (:hscopes ((:id . :x709.10.1) (:span 144 186))\n  ((:id . :x709.10.2) (:span 94 186)))\n (:identifiers (:sid . :s709.10) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006591@unknown@formal@none@1@S@SCL mRNA levels assessed by Northern blot in day 7 cells did not increase significantly in response to Steel factor stimulation, suggesting that posttranscriptional mechanisms may also be important in the increase in SCL protein observed in response to Steel.@(((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "northern") (:form . "Northern") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 87) (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 127)\n  (:start . 116) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 164) (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 197)\n  (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 213)\n  (:start . 205) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "SCL") (:form . "SCL") (:end . 220) (:start . 217)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 228)\n  (:start . 221) (:id . 77))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 237)\n  (:start . 229) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 79))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 249)\n  (:start . 241) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 252) (:start . 250)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Steel") (:form . "Steel") (:end . 258)\n  (:start . 253) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x709.11.1) (:span 176 179))\n  ((:id . :x709.11.2) (:span 129 139)))\n (:hscopes ((:id . :x709.11.1) (:span 176 258))\n  ((:id . :x709.11.2) (:span 129 258)))\n (:identifiers (:sid . :s709.11) (:did . :|7524762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006592@unknown@formal@none@1@S@Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.@(((:tag . "JJ") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s710.1) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006593@unknown@formal@none@1@S@The B cell-associated surface molecule CD40 functions to regulate B cell responses.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-associated") (:form . "cell-associated")\n  (:end . 21) (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s710.2) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006594@unknown@formal@none@1@S@Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production, and, in combination with cytokines, to Ig isotype switching.@(((:tag . "JJ") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homotypic") (:form . "homotypic") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 103)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 133)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x710.3.1) (:span 30 33)))\n (:hscopes ((:id . :x710.3.1) (:span 30 143)))\n (:identifiers (:sid . :s710.3) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006595@unknown@formal@none@1@S@Tyrosine kinase activity is increased shortly after engagement of this receptor.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "RB") (:stem . "shortly") (:form . "shortly") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s710.4) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006596@unknown@formal@none@1@S@Little is known about how the very early events induced by CD40 cross-linking link to cellular responses.@(((:tag . "JJ") (:stem . "little") (:form . "Little") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "VBP") (:stem . "link") (:form . "link") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s710.5) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006597@unknown@formal@none@1@S@In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 138) (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 143) (:start . 139)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "JJ") (:stem . "tonsillar") (:form . "tonsillar") (:end . 170)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 198)\n  (:start . 193) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s710.6) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006598@unknown@formal@none@1@S@The activation is rapid and is mediated through a tyrosine kinase-dependent pathway.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "kinase-dependent") (:form . "kinase-dependent")\n  (:end . 75) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s710.7) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006600@unknown@formal@none@1@S@By using transient transfection assays, we found that cross-linking CD40 supports NF-kappa B-dependent gene expression.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s710.9) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006601@unknown@formal@none@1@S@Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 59)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cell-associated") (:form . "cell-associated")\n  (:end . 167) (:start . 152) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 187)\n  (:start . 179) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 189) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 199)\n  (:start . 190) (:id . 73))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 205)\n  (:start . 200) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x710.10.1) (:span 88 95)))\n (:hscopes ((:id . :x710.10.1) (:span 88 205)))\n (:identifiers (:sid . :s710.10) (:did . :|7525701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006602@unknown@formal@none@1@S@Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.@(((:tag . "NN") (:stem . "separation") (:form . "Separation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "oxidant-initiated") (:form . "oxidant-initiated")\n  (:end . 31) (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "redox-regulated") (:form . "redox-regulated")\n  (:end . 51) (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 57) (:start . 52)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 95)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 103)\n  (:start . 96) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s711.1) (:did . :|7526398|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006603@unknown@formal@none@1@S@Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . 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"stimuli-specific")\n  (:end . 121) (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 170)\n  (:start . 162) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 177)\n  (:start . 171) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 183)\n  (:start . 178) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "oxidant") (:form . "oxidants") (:end . 194)\n  (:start . 186) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 196) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 213)\n  (:start . 205) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 217) (:start . 214)\n  (:id . 74))\n ((:tag . "NN") (:stem . "mitomycin") (:form . "mitomycin") (:end . 227)\n  (:start . 218) (:id . 75))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 229) (:start . 228)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 230) (:start . 229)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 231) (:start . 230)\n  (:id . 78))\n ((:tag . 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5006604@unknown@formal@none@1@S@These initial pathways culminate in a common pathway through which all of the stimulating agents ultimately signal NF-kappa B activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "culminate") (:form . "culminate") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "VBP") (:stem . "signal") (:form . "signal") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s711.3) (:did . :|7526398|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006605@unknown@formal@none@1@S@We distinguish the stimuli-specific pathways by showing that the oxidative stimuli trigger NF-kappa B activation in only one of two human T-cell lines (Wurzburg but not Jurkat), whereas tumor necrosis factor alpha and phorbol 12-myristate 13-acetate readily stimulate in both lines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "distinguish") (:form . "distinguish") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "stimuli-specific") (:form . "stimuli-specific")\n  (:end . 35) (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "VBP") (:stem . "trigger") (:form . "trigger") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 185)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 191)\n  (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 200)\n  (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 207)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 217) (:start . 214)\n  (:id . 77))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 225)\n  (:start . 218) (:id . 78))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 238)\n  (:start . 226) (:id . 79))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 249)\n  (:start . 239) (:id . 80))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 257)\n  (:start . 250) (:id . 81))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 267)\n  (:start . 258) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 270) (:start . 268)\n  (:id . 83))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 275) (:start . 271)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 281)\n  (:start . 276) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x711.4.1) (:span 165 168)))\n (:nscopes ((:id . :x711.4.1) (:span 165 175)))\n (:identifiers (:sid . :s711.4) (:did . :|7526398|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006606@unknown@formal@none@1@S@We propose the common pathway as the simplest way of accounting for the common requirements and properties of the signaling pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "simple") (:form . "simplest") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "account") (:form . "accounting") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 91)\n  (:start . 79) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s711.5) (:did . :|7526398|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006607@unknown@formal@none@1@S@We include a redox-regulatory mechanism(s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don't activate NF-kappa B); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47) is required for NF-kappa B activation by all stimuli tested in both cell lines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "redox-regulatory") (:form . "redox-regulatory")\n  (:end . 29) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 108)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "redox") (:form . 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"that") (:end . 283) (:start . 279)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 290)\n  (:start . 284) (:id . 88))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 299)\n  (:start . 291) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 301) (:start . 300)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "inhibitable") (:form . "inhibitable") (:end . 312)\n  (:start . 301) (:id . 91))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 315) (:start . 313)\n  (:id . 92))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 326)\n  (:start . 316) (:id . 93))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 328) (:start . 327)\n  (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 332) (:start . 329)\n  (:id . 95))\n ((:tag . "NN") (:stem . "tyrphostin") (:form . "tyrphostin") (:end . 343)\n  (:start . 333) (:id . 96))\n ((:tag . "CD") (:stem . "47") (:form . 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"stimuli") (:end . 400)\n  (:start . 393) (:id . 107))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 407)\n  (:start . 401) (:id . 108))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 410) (:start . 408)\n  (:id . 109))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 415) (:start . 411)\n  (:id . 110))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 420) (:start . 416)\n  (:id . 111))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 426)\n  (:start . 421) (:id . 112))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 427) (:start . 426)\n  (:id . 113)))@@@1@72@((:identifiers (:sid . :s711.6) (:did . :|7526398|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006608@unknown@formal@none@1@S@Since internal sites of oxidant production have been shown to play a key role in the cytokine-stimulated activation of NF-kappa B, and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . 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5006610@unknown@formal@none@1@S@We identified I kappa B alpha/MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion, lipopolysaccharide, and phorbol myristate acetate.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 57) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 146)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 155)\n  (:start . 147) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 175) (:start . 157) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 198)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 206)\n  (:start . 199) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s712.2) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006611@unknown@formal@none@1@S@Within 5 min of monocyte adhesion, the level of the I kappa B alpha protein is markedly diminished but is rapidly replaced in a cycloheximide-sensitive manner within 20 min.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 59) (:start . 54)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 67) (:start . 62)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 75)\n  (:start . 68) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 87)\n  (:start . 79) (:id . 59))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 98)\n  (:start . 88) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 113)\n  (:start . 106) (:id . 63))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cycloheximide-sensitive")\n  (:form . "cycloheximide-sensitive") (:end . 151) (:start . 128) (:id . 67))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 165)\n  (:start . 159) (:id . 69))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s712.3) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006612@unknown@formal@none@1@S@Accompanying the rapid turnover of the I kappa B alpha protein is simultaneous translocation of NF-kappa B-related transcription factors to nuclei of adhered monocytes.@(((:tag . "VBG") (:stem . "accompany") (:form . "Accompanying") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 78)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "adhered") (:form . "adhered") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 167)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s712.4) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006613@unknown@formal@none@1@S@The demonstration that NF-kappa B can regulate I kappa B alpha/MAD-3 gene transcription in other cell types suggested that the rapid increase in steady-state I kappa B alpha/MAD-3 mRNA levels we observed within 30 min of monocyte adherence would result from NF-kappa B-dependent transcriptional stimulation of the I kappa B alpha/MAD-3 gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "regulate") (:form . 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5006614@unknown@formal@none@1@S@Nuclear run-on analyses indicated that, instead, while several immediate-early cytokine genes, such as the interleukin 1 beta (IL-1 beta) gene, were transcriptionally activated during monocyte adhesion, the rate of I kappa B alpha/MAD-3 gene transcription remained constant.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 78) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 166) (:start . 149) (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 183)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 192)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 201)\n  (:start . 193) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 211) (:start . 207)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 222)\n  (:start . 217) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 224) (:start . 223)\n  (:id . 80))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 236)\n  (:start . 225) (:id . 81))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 241) (:start . 237)\n  (:id . 82))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 255) (:start . 242) (:id . 83))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 264)\n  (:start . 256) (:id . 84))\n ((:tag . "JJ") (:stem . "constant") (:form . "constant") (:end . 273)\n  (:start . 265) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x712.6.1) (:span 24 38)))\n (:hscopes ((:id . :x712.6.1) (:span 24 273)))\n (:identifiers (:sid . :s712.6) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006615@unknown@formal@none@1@S@The adherence-dependent increase in I kappa B alpha/MAD-3 mRNA levels was also not a consequence of mRNA stabilization events.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adherence-dependent")\n  (:form . "adherence-dependent") (:end . 23) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 32)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 118) (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x712.7.1) (:span 79 82)))\n (:nscopes ((:id . :x712.7.1) (:span 79 125)))\n (:identifiers (:sid . :s712.7) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006616@unknown@formal@none@1@S@Interestingly, while increases in both IL-1 beta and I kappa B alpha/MAD-3 mRNA levels were detected in nuclei of adherent monocytes, cytoplasmic levels of IL-1 beta mRNA increased during adherence whereas those of I kappa B alpha/MAD-3 mRNA did not.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 145)\n  (:start . 134) (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 180)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 187)\n  (:start . 181) (:id . 72))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 205)\n  (:start . 198) (:id . 74))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 211)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 222)\n  (:start . 217) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 224) (:start . 223)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "alpha/MAD-3") (:form . "alpha/MAD-3") (:end . 236)\n  (:start . 225) (:id . 80))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 241) (:start . 237)\n  (:id . 81))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 245) (:start . 242)\n  (:id . 82))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 249) (:start . 246)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x712.8.1) (:span 246 249)))\n (:nscopes ((:id . :x712.8.1) (:span 246 249)))\n (:identifiers (:sid . :s712.8) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006617@unknown@formal@none@1@S@Taken together, our data suggest that two interactive mechanisms regulate monocytic I kappa B alpha/MAD-3 mRNA levels.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "interactive") (:form . "interactive") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x712.9.1) (:span 25 32)))\n (:hscopes ((:id . :x712.9.1) (:span 25 117)))\n (:identifiers (:sid . :s712.9) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006618@unknown@formal@none@1@S@We propose that adherent monocytes regulate nuclear processing (or decay) of I kappa B alpha/MAD-3 mRNA, thereby increasing mRNA levels without stimulating I kappa B alpha/MAD-3 gene transcription.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "decay") (:form . "decay") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "alpha/MAD-3") (:form . "alpha/MAD-3") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "alpha/mad-3") (:form . "alpha/MAD-3") (:end . 177)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 182) (:start . 178)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 196) (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x712.10.2) (:span 3 10)))\n (:ncues ((:id . :x712.10.1) (:span 136 143)))\n (:hscopes ((:id . :x712.10.2) (:span 3 196)))\n (:nscopes ((:id . :x712.10.1) (:span 136 196)))\n (:identifiers (:sid . :s712.10) (:did . :|7532282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006620@unknown@formal@none@1@S@E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription.@(((:tag . "NNP") (:stem . "E2F-1") (:form . "E2F-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cyclin-like") (:form . "cyclin-like") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "uracil-dna") (:form . "uracil-DNA") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "glycosylase") (:form . "glycosylase") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 105) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s713.1) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006621@unknown@formal@none@1@S@The cell cycle-dependent transcription factor, E2F-1, regulates the cyclin-like species of the DNA repair enzyme uracil-DNA glycosylase (UDG) gene in human osteosarcoma (Saos-2) cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cycle-dependent") (:form . "cycle-dependent")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E2F-1") (:form . "E2F-1") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cyclin-like") (:form . "cyclin-like") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "uracil-dna") (:form . "uracil-DNA") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "glycosylase") (:form . "glycosylase") (:end . 135)\n  (:start . 124) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "UDG") (:form . "UDG") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "osteosarcoma") (:form . "osteosarcoma") (:end . 168)\n  (:start . 156) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "saos-2") (:form . "Saos-2") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s713.2) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006622@unknown@formal@none@1@S@We demonstrate, through the deletion of the human UDG promoter sequences, that expression of E2F-1 activates the UDG promoter through several E2F sites.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "UDG") (:form . "UDG") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E2F-1") (:form . "E2F-1") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "UDG") (:form . "UDG") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s713.3) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006623@unknown@formal@none@1@S@The major putative downstream site for E2F, located in the first exon, serves as a target for E2F-1/DP1 complex binding in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 89)\n  (:start . 83) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "e2f-1/dp1") (:form . "E2F-1/DP1") (:end . 103)\n  (:start . 94) (:id . 61))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s713.4) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006624@unknown@formal@none@1@S@We also provide evidence for the functional relationship between the cyclin-like UDG gene product and E2F.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cyclin-like") (:form . "cyclin-like") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "NNP") (:stem . "UDG") (:form . "UDG") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s713.5) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006625@unknown@formal@none@1@S@High levels of UDG expression in a transient transfection assay result in the down-regulation of transcriptional activity through elements specific for E2F-mediated transcription.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "udg") (:form . "UDG") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 57)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 112) (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 129)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "e2f-mediated") (:form . "E2F-mediated") (:end . 164)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 178) (:start . 165) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s713.6) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006626@unknown@formal@none@1@S@Overexpression of UDG in Saos 2 cells was observed to delay growth late in G1 phase and transiently arrest these cells from progressing into the S phase.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "UDG") (:form . "UDG") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Saos") (:form . "Saos") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "delay") (:form . "delay") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 99)\n  (:start . 88) (:id . 59))\n ((:tag . "VB") (:stem . "arrest") (:form . "arrest") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "progress") (:form . "progressing") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s713.7) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006627@unknown@formal@none@1@S@This hypothetical model integrates one mechanism of DNA repair with the cell cycle control of gene transcription, likely through E2F.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "integrate") (:form . "integrates") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x713.8.1) (:span 114 120)))\n (:hscopes ((:id . :x713.8.1) (:span 114 132)))\n (:identifiers (:sid . :s713.8) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006628@unknown@formal@none@1@S@This implicates E2F as a multifunctional target for proteins and enzymes, possibly, responsive to DNA damage through the negative effect of UDG on E2F-mediated transcriptional activity.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "implicate") (:form . "implicates") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "multifunctional") (:form . "multifunctional")\n  (:end . 40) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "UDG") (:form . "UDG") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "e2f-mediated") (:form . "E2F-mediated") (:end . 159)\n  (:start . 147) (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 175) (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x713.9.1) (:span 74 82)))\n (:hscopes ((:id . :x713.9.1) (:span 0 184)))\n (:identifiers (:sid . :s713.9) (:did . :|7534293|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006630@unknown@formal@none@1@S@BACKGROUND: The induction of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin by tumor necrosis factor-alpha (TNF) is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B).@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 117)\n  (:start . 105) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 151)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 172) (:start . 159) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 179)\n  (:start . 173) (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 200)\n  (:start . 188) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 202) (:start . 201)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 204) (:start . 203)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 212)\n  (:start . 204) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 214) (:start . 213)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s714.2) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006631@unknown@formal@none@1@S@Since salicylates have been reported to inhibit NF-kappa B activation by preventing the degradation of its inhibitor I kappa B, we studied a potential inhibition of this pathway by acetylsalicylate (aspirin) in human umbilical vein endothelial cells (HUVECs).@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "salicylate") (:form . "salicylates") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 161)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 71))\n ((:tag . "NN") (:stem . "acetylsalicylate") (:form . "acetylsalicylate")\n  (:end . 197) (:start . 181) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 206)\n  (:start . 199) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 216)\n  (:start . 211) (:id . 77))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 226)\n  (:start . 217) (:id . 78))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 231) (:start . 227)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 243)\n  (:start . 232) (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 249)\n  (:start . 244) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 251) (:start . 250)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 257)\n  (:start . 251) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 258) (:start . 257)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s714.3) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006632@unknown@formal@none@1@S@METHODS AND RESULTS: Gel-shift analyses demonstrated dose-dependent inhibition of TNF-induced NF-kappa B mobilization by aspirin at concentrations ranging from 1 to 10 mmol/L.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "Gel-shift") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 67) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tnf-induced") (:form . "TNF-induced") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 102)\n  (:start . 94) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 117)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 56))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 131) (:start . 129)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 146) (:start . 132) (:id . 59))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 154)\n  (:start . 147) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 159) (:start . 155)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 161) (:start . 160)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mmol/l") (:form . "mmol/L") (:end . 174)\n  (:start . 168) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s714.4) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006633@unknown@formal@none@1@S@Induction of VCAM-1 and E-selectin surface expression by TNF was dose-dependently reduced by aspirin over the same range, while induction of intercellular adhesion molecule-1 (ICAM-1) was hardly affected.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 81) (:start . 65) (:id . 52))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 154) (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 174)\n  (:start . 164) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 182)\n  (:start . 176) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . "RB") (:stem . "hardly") (:form . "hardly") (:end . 194)\n  (:start . 188) (:id . 71))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 203)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s714.5) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006634@unknown@formal@none@1@S@Aspirin appeared to prevent VCAM-1 transcription, since it dose-dependently inhibited induction of VCAM-1 mRNA by TNF.@(((:tag . "NN") (:stem . "aspirin") (:form . "Aspirin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 75) (:start . 59) (:id . 51))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 95)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x714.6.1) (:span 8 16)))\n (:hscopes ((:id . :x714.6.1) (:span 0 48)))\n (:identifiers (:sid . :s714.6) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006635@unknown@formal@none@1@S@As a functional consequence, adhesion of U937 monocytes to TNF-stimulated HUVECs was markedly reduced by aspirin due to suppression of VCAM-1 and E-selectin upregulation.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 15)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tnf-stimulated") (:form . "TNF-stimulated")\n  (:end . 73) (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 131)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 141)\n  (:start . 135) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 169)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s714.7) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006636@unknown@formal@none@1@S@These effects of aspirin were not related to the inhibition of cyclooxygenase activity, since indomethacin was ineffective.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cyclooxygenase") (:form . "cyclooxygenase")\n  (:end . 77) (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x714.8.1) (:span 30 33)))\n (:nscopes ((:id . :x714.8.1) (:span 0 86)))\n (:identifiers (:sid . :s714.8) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006637@unknown@formal@none@1@S@CONCLUSIONS: Our data suggest that aspirin inhibits NF-kappa B mobilization, induction of VCAM-1 and E-selectin, and subsequent monocyte adhesion in endothelial cells stimulated by TNF, thereby providing an additional mechanism for therapeutic effects of aspirin.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 75)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 160)\n  (:start . 149) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 66))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 177)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 193)\n  (:start . 186) (:id . 71))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 203)\n  (:start . 194) (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 217)\n  (:start . 207) (:id . 74))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 227)\n  (:start . 218) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 231) (:start . 228)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 243)\n  (:start . 232) (:id . 77))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 251)\n  (:start . 244) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 254) (:start . 252)\n  (:id . 79))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 262)\n  (:start . 255) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x714.9.1) (:span 22 29)))\n (:hscopes ((:id . :x714.9.1) (:span 22 262)))\n (:identifiers (:sid . :s714.9) (:did . :|7534663|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006638@unknown@formal@none@1@S@Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion.@(((:tag . "NNP") (:stem . "Monocyte") (:form . "Monocyte") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tethering") (:form . "tethering") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 73)\n  (:start . 64) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 83) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 105)\n  (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 115)\n  (:start . 106) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s715.1) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006640@unknown@formal@none@1@S@Adhesion molecules that tether circulating leukocytes to endothelial cells may also transduce or modulate outside-in signals for cellular activation, providing an initial regulatory point in the inflammatory response.@(((:tag . "NNP") (:stem . "Adhesion") (:form . "Adhesion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "tether") (:form . "tether") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 68)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . "JJ") (:stem . "outside-in") (:form . "outside-in") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 124)\n  (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 137)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 148)\n  (:start . 138) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 159)\n  (:start . 150) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 170)\n  (:start . 163) (:id . 64))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 181)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 187)\n  (:start . 182) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 207)\n  (:start . 195) (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 216)\n  (:start . 208) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x715.3.1) (:span 94 96)) ((:id . :x715.3.2) (:span 75 78)))\n (:hscopes ((:id . :x715.3.1) (:span 84 105))\n  ((:id . :x715.3.2) (:span 75 216)))\n (:identifiers (:sid . :s715.3) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006641@unknown@formal@none@1@S@Adhesion of human monocytes to P-selectin, the most rapidly expressed endothelial tethering factor, increased the secretion of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) by the leukocytes when they were stimulated with platelet-activating factor.@(((:tag . "NNP") (:stem . "Adhesion") (:form . "Adhesion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "tethering") (:form . "tethering") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 147)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 157)\n  (:start . 148) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 175)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 197)\n  (:start . 185) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 208)\n  (:start . 199) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 227)\n  (:start . 217) (:id . 76))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 232) (:start . 228)\n  (:id . 77))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 237) (:start . 233)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 242) (:start . 238)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 253)\n  (:start . 243) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 258) (:start . 254)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 278) (:start . 259) (:id . 82))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 285)\n  (:start . 279) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s715.4) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006642@unknown@formal@none@1@S@Increased cytokine secretion was specifically inhibited by G1, an anti-P-selectin mAb that prevents P-selectin from binding to its ligand (P-selectin glycoprotein ligand-1) on myeloid cells.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-p-selectin") (:form . "anti-P-selectin")\n  (:end . 81) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 137)\n  (:start . 131) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 149)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 162)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "ligand-1") (:form . "ligand-1") (:end . 171)\n  (:start . 163) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s715.5) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006643@unknown@formal@none@1@S@Moreover, tethering by P-selectin specifically enhanced nuclear translocation of nuclear factor-kappa B (NF-kappa B), a transcription factor required for expression of MCP-1, TNF-alpha, and other immediate-early genes.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "tethering") (:form . "tethering") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 77) (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 101)\n  (:start . 89) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 140)\n  (:start . 134) (:id . 62))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 173)\n  (:start . 168) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 184)\n  (:start . 175) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 195)\n  (:start . 190) (:id . 72))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 211) (:start . 196) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 217)\n  (:start . 212) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s715.6) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006644@unknown@formal@none@1@S@These results demonstrate that P-selectin, through its ligands on monocytes, may locally regulate cytokine secretion in inflamed tissues.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "locally") (:form . "locally") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inflamed") (:form . "inflamed") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x715.7.1) (:span 77 80)))\n (:hscopes ((:id . :x715.7.1) (:span 77 136)))\n (:identifiers (:sid . :s715.7) (:did . :|7537762|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006645@unknown@formal@none@1@S@Danazol decreases transcription of estrogen receptor gene in human monocytes.@(((:tag . "NNP") (:stem . "Danazol") (:form . "Danazol") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s716.1) (:did . :|7540578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006646@unknown@formal@none@1@S@1. Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes.@(((:tag . "LS") (:stem . "1.") (:form . "1.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "administration") (:form . "Administration")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "danazol") (:form . "danazol") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "month") (:form . "month") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 122) (:start . 109) (:id . 63))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 68))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 147)\n  (:start . 135) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 160)\n  (:start . 151) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s716.2) (:did . :|7540578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006647@unknown@formal@none@1@S@2. Danazol did not alter the degradation rate of ER mRNA in monocytes.@(((:tag . "LS") (:stem . "2.") (:form . "2.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Danazol") (:form . "Danazol") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x716.3.1) (:span 15 18)))\n (:nscopes ((:id . :x716.3.1) (:span 15 69)))\n (:identifiers (:sid . :s716.3) (:did . :|7540578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006648@unknown@formal@none@1@S@3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay.@(((:tag . "LS") (:stem . "3.") (:form . "3.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Danazol") (:form . "Danazol") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s716.4) (:did . :|7540578|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006650@unknown@formal@none@1@S@Cross-linking of CD30 induces HIV expression in chronically infected T cells.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s717.1) (:did . :|7540942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5006653@unknown@formal@none@1@S@CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNF alpha/beta.@(((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha/beta") (:form . "alpha/beta") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x717.4.1) (:span 102 105))\n  ((:id . :x717.4.2) (:span 24 27)))\n (:nscopes ((:id . :x717.4.1) (:span 67 143))\n  ((:id . :x717.4.2) (:span 24 62)))\n (:identifiers (:sid . :s717.4) (:did . :|7540942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5006655@unknown@formal@none@1@S@Thus, CD30-CD30L interactions mediate the induction of HIV expression by a kappa B-dependent pathway that is independent of TNF.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "cd30-cd30l") (:form . "CD30-CD30L") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s717.6) (:did . :|7540942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006656@unknown@formal@none@1@S@This mechanism may be important in the activation of HIV expression from latently infected CD4+ T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "conducive") (:form . "conducive") (:end . 174)\n  (:start . 165) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "receptor-ligand") (:form . "receptor-ligand")\n  (:end . 193) (:start . 178) (:id . 72))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 206)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x717.7.1) (:span 15 18)))\n (:hscopes ((:id . :x717.7.1) (:span 15 206)))\n (:identifiers (:sid . :s717.7) (:did . :|7540942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006657@unknown@formal@none@1@S@Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.@(((:tag . "JJ") (:stem . "integrin-mediated") (:form . "Integrin-mediated")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 26)\n  (:start . 18) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 42) (:start . 27) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 55)\n  (:start . 47) (:id . 46))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 63)\n  (:start . 56) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 86)\n  (:start . 77) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s718.1) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006658@unknown@formal@none@1@S@A possible signaling role for the Syk tyrosine kinase.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Syk") (:form . "Syk") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x718.2.1) (:span 2 10)))\n (:hscopes ((:id . :x718.2.1) (:span 2 53)))\n (:identifiers (:sid . :s718.2) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006660@unknown@formal@none@1@S@In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "integrin-dependent") (:form . "integrin-dependent")\n  (:end . 65) (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "intense") (:form . "intense") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 194) (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 218)\n  (:start . 210) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 76))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 227)\n  (:start . 222) (:id . 77))\n ((:tag . "CD") (:stem . "65-75") (:form . "65-75") (:end . 233)\n  (:start . 228) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 237) (:start . 234)\n  (:id . 79))\n ((:tag . "CD") (:stem . "120-125") (:form . "120-125") (:end . 245)\n  (:start . 238) (:id . 80))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 249) (:start . 246)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s718.4) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006661@unknown@formal@none@1@S@In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . 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5006662@unknown@formal@none@1@S@The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "integrin-mediated") (:form . "integrin-mediated")\n  (:end . 86) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 111) (:start . 96) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 125)\n  (:start . 116) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 146)\n  (:start . 139) (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 153)\n  (:start . 147) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "causal") (:form . "causal") (:end . 174)\n  (:start . 168) (:id . 65))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 187)\n  (:start . 175) (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 195)\n  (:start . 188) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 203) (:start . 200)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 210)\n  (:start . 204) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s718.6) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006663@unknown@formal@none@1@S@The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 38) (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 49)\n  (:start . 39) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "paxillin") (:form . "paxillin") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pp125fak") (:form . "pp125FAK") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "NNP") (:stem . "Syk") (:form . "Syk") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s718.7) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006664@unknown@formal@none@1@S@In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 79) (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Syk") (:form . "Syk") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FAK") (:form . "FAK") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "paxillin") (:form . "paxillin") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x718.8.1) (:span 91 94)))\n (:nscopes ((:id . :x718.8.1) (:span 91 113)))\n (:identifiers (:sid . :s718.8) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006665@unknown@formal@none@1@S@In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adhering") (:form . "adhering") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pre-treatment") (:form . "pre-treatment")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytochalasin") (:form . "cytochalasin") (:end . 50)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 88) (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "FAK") (:form . "FAK") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "paxillin") (:form . "paxillin") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Syk") (:form . "Syk") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 148)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x718.9.1) (:span 113 116)))\n (:nscopes ((:id . :x718.9.1) (:span 113 123)))\n (:identifiers (:sid . :s718.9) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006666@unknown@formal@none@1@S@These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Syk") (:form . "Syk") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 161)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 192)\n  (:start . 183) (:id . 72))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 199)\n  (:start . 193) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 211)\n  (:start . 203) (:id . 75))\n ((:tag . "NNS") (:stem . "message") (:form . "messages") (:end . 220)\n  (:start . 212) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x718.10.1) (:span 57 60))\n  ((:id . :x718.10.2) (:span 19 32)))\n (:hscopes ((:id . :x718.10.1) (:span 57 138))\n  ((:id . :x718.10.2) (:span 19 220)))\n (:identifiers (:sid . :s718.10) (:did . :|7541794|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006667@unknown@formal@none@1@S@Nitric oxide decreases cytokine-induced endothelial activation.@(((:tag . "JJ") (:stem . "nitric") (:form . "Nitric") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 39) (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 51)\n  (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s719.1) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006668@unknown@formal@none@1@S@Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.@(((:tag . "JJ") (:stem . "nitric") (:form . "Nitric") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 97) (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 107)\n  (:start . 98) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s719.2) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006670@unknown@formal@none@1@S@In a concentration-dependent manner, NO inhibited interleukin (IL)-1 alpha-stimulated VCAM-1 expression by 35-55% as determined by cell surface enzyme immunoassays and flow cytometry.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 28) (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "IL)-1") (:form . "IL)-1") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "alpha-stimulated") (:form . "alpha-stimulated")\n  (:end . 85) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "CD") (:stem . "35-55") (:form . "35-55") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "NNS") (:stem . "immunoassay") (:form . "immunoassays") (:end . 163)\n  (:start . 151) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 182)\n  (:start . 173) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s719.4) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006671@unknown@formal@none@1@S@This inhibition was paralleled by reduced monocyte adhesion to endothelial monolayers in nonstatic assays, was unaffected by cGMP analogues, and was quantitatively similar after stimulation by either IL-1 alpha, IL-1 beta, IL-4, tumor necrosis factor (TNF alpha), or bacterial lipopolysaccharide.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "parallel") (:form . "paralleled") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "monocyte") (:form . 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5006672@unknown@formal@none@1@S@NO also decreased the endothelial expression of other leukocyte adhesion molecules (E-selectin and to a lesser extent, intercellular adhesion molecule-1) and secretable cytokines (IL-6 and IL-8).@(((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "secretable") (:form . "secretable") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s719.6) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006673@unknown@formal@none@1@S@Inhibition of endogenous NO production by L-N-monomethyl-arginine also induced the expression of VCAM-1, but did not augment cytokine-induced VCAM-1 expression.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "L-N-monomethyl-arginine")\n  (:form . "L-N-monomethyl-arginine") (:end . 65) (:start . 42) (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 103)\n  (:start . 97) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 141) (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x719.7.1) (:span 113 116)))\n (:nscopes ((:id . :x719.7.1) (:span 113 159)))\n (:identifiers (:sid . :s719.7) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006674@unknown@formal@none@1@S@Nuclear run-on assays, transfection studies using various VCAM-1 promoter reporter gene constructs, and electrophoretic mobility shift assays indicated that NO represses VCAM-1 gene transcription, in part, by inhibiting NF-kappa B.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 119) (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 128)\n  (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 62))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 159) (:start . 157)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 169)\n  (:start . 160) (:id . 64))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 176)\n  (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 181) (:start . 177)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 195) (:start . 182) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 204) (:start . 200)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 219)\n  (:start . 209) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 228)\n  (:start . 220) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 230) (:start . 229)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x719.8.1) (:span 142 156)))\n (:hscopes ((:id . :x719.8.1) (:span 142 230)))\n (:identifiers (:sid . :s719.8) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006675@unknown@formal@none@1@S@We propose that NO's ability to limit endothelial activation and inhibit monocyte adhesion may contribute to some of its antiatherogenic and antiinflammatory properties within the vessel wall.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . "limit") (:form . "limit") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antiatherogenic") (:form . "antiatherogenic")\n  (:end . 136) (:start . 121) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 157) (:start . 141) (:id . 64))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 168)\n  (:start . 158) (:id . 65))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 175)\n  (:start . 169) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "vessel") (:form . "vessel") (:end . 186)\n  (:start . 180) (:id . 68))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x719.9.1) (:span 91 94)) ((:id . :x719.9.2) (:span 3 10)))\n (:hscopes ((:id . :x719.9.1) (:span 91 191))\n  ((:id . :x719.9.2) (:span 3 191)))\n (:identifiers (:sid . :s719.9) (:did . :|7542286|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006676@unknown@formal@none@1@S@Distinct signaling properties identify functionally different CD4 epitopes.@(((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 51)\n  (:start . 39) (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 61)\n  (:start . 52) (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 65) (:start . 62)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s720.1) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006677@unknown@formal@none@1@S@The CD4 coreceptor interacts with non-polymorphic regions of major histocompatibility complex class II molecules on antigen-presenting cells and contributes to T cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coreceptor") (:form . "coreceptor") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "non-polymorphic") (:form . "non-polymorphic")\n  (:end . 49) (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 85) (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 93)\n  (:start . 86) (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 134) (:start . 116) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 156)\n  (:start . 145) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 166) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 177)\n  (:start . 167) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s720.2) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006678@unknown@formal@none@1@S@We have investigated the effect of CD4 triggering on T cell activating signals in a lymphoma model using monoclonal antibodies (mAb) which recognize different CD4 epitopes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s720.3) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006680@unknown@formal@none@1@S@Whereas different anti-CD4 mAb or HIV-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the Shc adaptor protein, which mediates signals to Ras, they differed significantly in their ability to activate NF-AT.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "anti-cd4") (:form . "anti-CD4") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gp120") (:form . "gp120") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "trigger") (:form . "trigger") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 144) (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Shc") (:form . "Shc") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 195)\n  (:start . 188) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 74))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 217)\n  (:start . 209) (:id . 76))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 231) (:start . 218) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 234) (:start . 232)\n  (:id . 78))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 240)\n  (:start . 235) (:id . 79))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 248)\n  (:start . 241) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 251) (:start . 249)\n  (:id . 81))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 260)\n  (:start . 252) (:id . 82))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 266)\n  (:start . 261) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s720.5) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006681@unknown@formal@none@1@S@Lack of full activation of NF-AT could be correlated to a dramatically reduced capacity to induce calcium flux and could be complemented with a calcium ionophore.@(((:tag . "NN") (:stem . "lack") (:form . "Lack") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "flux") (:form . "flux") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "complement") (:form . "complemented") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 161)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x720.6.1) (:span 115 120))\n  ((:id . :x720.6.3) (:span 33 38)))\n (:ncues ((:id . :x720.6.2) (:span 0 4)))\n (:hscopes ((:id . :x720.6.1) (:span 115 161))\n  ((:id . :x720.6.3) (:span 0 32)))\n (:nscopes ((:id . :x720.6.2) (:span 0 110)))\n (:identifiers (:sid . :s720.6) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006682@unknown@formal@none@1@S@The results identify functionally distinct epitopes on the CD4 coreceptor involved in activation of the Ras/protein kinase C and calcium pathways.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "coreceptor") (:form . "coreceptor") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ras/protein") (:form . "Ras/protein") (:end . 115)\n  (:start . 104) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 145)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s720.7) (:did . :|7542591|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006683@unknown@formal@none@1@S@Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.@(((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "Lipopolysaccharide-induced") (:end . 26) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 37)\n  (:start . 27) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 44))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 57)\n  (:start . 49) (:id . 45))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 68)\n  (:start . 58) (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 77)\n  (:start . 69) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 84) (:start . 81)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 101)\n  (:start . 92) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "bactericidal/permeability-increasing")\n  (:form . "bactericidal/permeability-increasing") (:end . 141) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 149)\n  (:start . 142) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s721.1) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006684@unknown@formal@none@1@S@Endothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation.@(((:tag . "JJ") (:stem . "endothelial") (:form . "Endothelial") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 138)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s721.2) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006685@unknown@formal@none@1@S@E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h.@(((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "CD") (:stem . "1-2") (:form . "1-2") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "peak") (:form . "peaks") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "CD") (:stem . "4-6") (:form . "4-6") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "RB") (:stem . "gradually") (:form . "gradually") (:end . 65)\n  (:start . 56) (:id . 55))\n ((:tag . "VBZ") (:stem . "return") (:form . "returns") (:end . 73)\n  (:start . 66) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 82) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 88) (:start . 83)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s721.3) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006686@unknown@formal@none@1@S@rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS.@(((:tag . "NN") (:stem . "rbpi21") (:form . "rBPI21") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 21)\n  (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "bactericidal/permeability-increasing")\n  (:form . "bactericidal/permeability-increasing") (:end . 87) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "BPI") (:form . "BPI") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 124)\n  (:start . 113) (:id . 57))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 135)\n  (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 151) (:start . 147)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 157) (:start . 152)\n  (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 160) (:start . 158)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 174) (:start . 170)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 188) (:start . 186)\n  (:id . 70))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 198)\n  (:start . 193) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 203) (:start . 200)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s721.4) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006687@unknown@formal@none@1@S@Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B.@(((:tag . "VBN") (:stem . "delay") (:form . "Delayed") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "administration") (:form . "administration")\n  (:end . 22) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rbpi21") (:form . "rBPI21") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "affect") (:form . "affected") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 59)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s721.5) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006688@unknown@formal@none@1@S@Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 20)\n  (:start . 11) (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 48)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rbpi21") (:form . "rBPI21") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 132)\n  (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 167)\n  (:start . 157) (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 172) (:start . 171)\n  (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 177) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 179) (:start . 178)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s721.6) (:did . :|7543076|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006690@unknown@formal@none@1@S@Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LFA-3") (:form . "LFA-3") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B7") (:form . "B7") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s722.1) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006691@unknown@formal@none@1@S@We have earlier shown that stimulation of human CD4+ T cells with SEA presented on Chinese hamster ovary (CHO)-DR transfectants coexpressing either B7 or LFA-3 resulted in distinct cytokine profiles.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SEA") (:form . "SEA") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "chinese") (:form . "Chinese") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "hamster") (:form . "hamster") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "ovary") (:form . "ovary") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CHO)-DR") (:form . "CHO)-DR") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 127) (:start . 114) (:id . 62))\n ((:tag . "VBG") (:stem . "coexpresse") (:form . "coexpressing") (:end . 140)\n  (:start . 128) (:id . 63))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "NNP") (:stem . "B7") (:form . "B7") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "LFA-3") (:form . "LFA-3") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 180)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s722.2) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006692@unknown@formal@none@1@S@We now demonstrate that B7, but not LFA-3, strongly costimulated IL-2 transcription and mRNA expression in CD4+ T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "b7") (:form . "B7") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lfa-3") (:form . "LFA-3") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "VBD") (:stem . "costimulate") (:form . "costimulated") (:end . 64)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x722.3.1) (:span 32 35)))\n (:nscopes ((:id . :x722.3.1) (:span 32 41)))\n (:identifiers (:sid . :s722.3) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006693@unknown@formal@none@1@S@Maximal increase in IL-2 transcription was recorded with CHO-DR/B7/LFA-3, suggesting a cooperative effect of B7 and LFA-3 at the transcriptional level.@(((:tag . "JJ") (:stem . "maximal") (:form . "Maximal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "record") (:form . "recorded") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CHO-DR/B7/LFA-3") (:form . "CHO-DR/B7/LFA-3")\n  (:end . 72) (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B7") (:form . "B7") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LFA-3") (:form . "LFA-3") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 144) (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x722.4.1) (:span 74 84)))\n (:hscopes ((:id . :x722.4.1) (:span 74 150)))\n (:identifiers (:sid . :s722.4) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006694@unknown@formal@none@1@S@Gel-shift analysis demonstrated that stimulation of CD4+ T cells with CHO-DR and staphylococcal enterotoxin A was sufficient to induce significant amounts of NF-kappa B binding proteins, whereas induction of AP-1 binding proteins required costimulation.@(((:tag . "JJ") (:stem . "gel-shift") (:form . "Gel-shift") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 31)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CHO-DR") (:form . "CHO-DR") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 95) (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "enterotoxin") (:form . "enterotoxin") (:end . 107)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 146)\n  (:start . 135) (:id . 61))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 154)\n  (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 166)\n  (:start . 158) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 176)\n  (:start . 169) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 185)\n  (:start . 177) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 68))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 194)\n  (:start . 187) (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 204)\n  (:start . 195) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 212) (:start . 208)\n  (:id . 72))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 220)\n  (:start . 213) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 229)\n  (:start . 221) (:id . 74))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 238)\n  (:start . 230) (:id . 75))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 252) (:start . 239) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s722.5) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006695@unknown@formal@none@1@S@LFA-3 induced moderate levels of AP-1, but did not influence the levels of NF-kappa B, while B7 costimulation strongly induced both AP-1 and substantially enhanced NF-kappa B binding proteins.@(((:tag . "NNP") (:stem . "LFA-3") (:form . "LFA-3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "moderate") (:form . "moderate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 92) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "b7") (:form . "B7") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 109) (:start . 96) (:id . 61))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 154) (:start . 141) (:id . 67))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 163)\n  (:start . 155) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 191)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x722.6.1) (:span 47 50)))\n (:nscopes ((:id . :x722.6.1) (:span 47 85)))\n (:identifiers (:sid . :s722.6) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006696@unknown@formal@none@1@S@The CHO-DR/B7/LFA-3 triple transfectant induced a further increase in AP-1 and NF-kappa B binding proteins compared with the double transfectants.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cho-dr/b7/lfa-3") (:form . "CHO-DR/B7/LFA-3")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "triple") (:form . "triple") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "transfectant") (:form . "transfectant") (:end . 39)\n  (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 145) (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s722.7) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006697@unknown@formal@none@1@S@The level of Oct-1 binding proteins remained similar in all samples.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s722.8) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006698@unknown@formal@none@1@S@Super-shift analysis revealed that the NF-kappa B complex of costimulated CD4+ T cells contained large amounts of p50, substantial amounts of p65, and marginal levels of c-Rel proteins.@(((:tag . "JJ") (:stem . "super-shift") (:form . "Super-shift") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "costimulate") (:form . "costimulated") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "marginal") (:form . "marginal") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 184)\n  (:start . 176) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s722.9) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006700@unknown@formal@none@1@S@Our results indicate distinct effects of B7 and LFA-3 costimulation on the activity of AP-1 and NF-kappa B.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B7") (:form . "B7") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lfa-3") (:form . "LFA-3") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s722.11) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006701@unknown@formal@none@1@S@These may partly account for the differential effects of B7 and LFA-3 costimulation on IL-2 expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B7") (:form . "B7") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lfa-3") (:form . "LFA-3") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x722.12.1) (:span 6 9)))\n (:hscopes ((:id . :x722.12.1) (:span 6 102)))\n (:identifiers (:sid . :s722.12) (:did . :|7543515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006702@unknown@formal@none@1@S@Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 36) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 55) (:start . 37) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 77)\n  (:start . 67) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 103)\n  (:start . 92) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 124)\n  (:start . 113) (:id . 54))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 126) (:start . 125)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 141)\n  (:start . 135) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 155) (:start . 142) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 162)\n  (:start . 156) (:id . 60))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 167) (:start . 163)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s723.1) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006703@unknown@formal@none@1@S@Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA).@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 88) (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "WDT") (:stem . "athat") (:form . "athat") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "VBD") (:stem . "support") (:form . "supported") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 181)\n  (:start . 173) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 202) (:start . 186) (:id . 70))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 210)\n  (:start . 203) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 225)\n  (:start . 214) (:id . 73))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 227) (:start . 226)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 232) (:start . 229)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s723.2) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006704@unknown@formal@none@1@S@As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 78) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 99) (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s723.3) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006705@unknown@formal@none@1@S@Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%.@(((:tag . "RB") (:stem . "significantly") (:form . "Significantly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 136) (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 155) (:start . 137) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 162)\n  (:start . 156) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 170)\n  (:start . 164) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 176) (:start . 172)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 187)\n  (:start . 177) (:id . 66))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 196)\n  (:start . 188) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 201) (:start . 197)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 205) (:start . 202)\n  (:id . 69))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 210) (:start . 206)\n  (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 213) (:start . 211)\n  (:id . 71))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 216) (:start . 214)\n  (:id . 72))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 217) (:start . 216)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s723.4) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006706@unknown@formal@none@1@S@CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s723.5) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006707@unknown@formal@none@1@S@CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 108)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 151)\n  (:start . 143) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 164)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 195) (:start . 191)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x723.6.1) (:span 179 190))\n  ((:id . :x723.6.2) (:span 36 39)))\n (:nscopes ((:id . :x723.6.1) (:span 179 195))\n  ((:id . :x723.6.2) (:span 36 114)))\n (:identifiers (:sid . :s723.6) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006708@unknown@formal@none@1@S@Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion.@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF)-alpha") (:form . "TNF)-alpha") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 172) (:start . 169)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "reflect") (:form . "reflected") (:end . 182)\n  (:start . 173) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 76))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 190) (:start . 188)\n  (:id . 77))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 191) (:start . 190)\n  (:id . 78))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 200)\n  (:start . 192) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 80))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 214)\n  (:start . 204) (:id . 81))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 223)\n  (:start . 215) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s723.7) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006710@unknown@formal@none@1@S@This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 136) (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x723.9.1) (:span 99 104)) ((:id . :x723.9.2) (:span 66 74)))\n (:hscopes ((:id . :x723.9.1) (:span 99 142))\n  ((:id . :x723.9.2) (:span 66 142)))\n (:identifiers (:sid . :s723.9) (:did . :|7545467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006711@unknown@formal@none@1@S@Signalling via CD28 of human naive neonatal T lymphocytes.@(((:tag . "NN") (:stem . "signalling") (:form . "Signalling") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s724.1) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006712@unknown@formal@none@1@S@Accessory molecules play a crucial role in the development of the T cell response to antigenic challenge.@(((:tag . "JJ") (:stem . "accessory") (:form . "Accessory") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s724.2) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006713@unknown@formal@none@1@S@We have examined the role of CD28 in modulating the 'naive' neonatal T cell response to anti-CD2-mediated activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "'naive") (:form . "'naive") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-cd2-mediated") (:form . "anti-CD2-mediated")\n  (:end . 105) (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s724.3) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006714@unknown@formal@none@1@S@To compare the role of CD28, neonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti-CD28 MoAb.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 71)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 96)\n  (:start . 87) (:id . 60))\n ((:tag . "JJ") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 105)\n  (:start . 97) (:id . 61))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 116)\n  (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 132)\n  (:start . 124) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 156)\n  (:start . 147) (:id . 69))\n ((:tag . "NNP") (:stem . "MoAb") (:form . "MoAb") (:end . 161) (:start . 157)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x724.4.1) (:span 136 143)))\n (:nscopes ((:id . :x724.4.1) (:span 136 161)))\n (:identifiers (:sid . :s724.4) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006715@unknown@formal@none@1@S@With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2, whereas adult T cells proliferated vigorously, with significant IL-2 production.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "proliferate") (:form . "proliferated") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "VBD") (:stem . "proliferate") (:form . "proliferated") (:end . 127)\n  (:start . 115) (:id . 61))\n ((:tag . "RB") (:stem . "vigorously") (:form . "vigorously") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 156)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x724.5.1) (:span 73 75)))\n (:nscopes ((:id . :x724.5.1) (:span 73 91)))\n (:identifiers (:sid . :s724.5) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006716@unknown@formal@none@1@S@Costimulation with anti-CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells, whereas adult T cells showed only slight increases.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NNP") (:stem . "MoAb") (:form . "MoAb") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 68) (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 174)\n  (:start . 168) (:id . 69))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 186)\n  (:start . 180) (:id . 71))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 196)\n  (:start . 187) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s724.6) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006717@unknown@formal@none@1@S@Although IL-2 secretion was increased in the presence of anti-CD28 MoAb, neonatal T cell IL-2 production remained lower than in adults.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NNP") (:stem . "MoAb") (:form . "MoAb") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 119) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s724.7) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006718@unknown@formal@none@1@S@In contrast, enhancement of IL-2 mRNA expression in neonates was similar to adult levels.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "neonate") (:form . "neonates") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s724.8) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006720@unknown@formal@none@1@S@The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction, reduced IL-2 mRNA expression and deficient IL-2 production.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBG") (:stem . "govern") (:form . "governing") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 61) (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 96)\n  (:start . 85) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "anti-cd2") (:form . "anti-CD2") (:end . 108)\n  (:start . 100) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 142)\n  (:start . 133) (:id . 61))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 172)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 207)\n  (:start . 198) (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 212) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 223)\n  (:start . 213) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x724.10.1) (:span 109 112)))\n (:hscopes ((:id . :x724.10.1) (:span 109 223)))\n (:identifiers (:sid . :s724.10) (:did . :|7554389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5006722@unknown@formal@none@1@S@Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 36) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s725.1) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5006725@unknown@formal@none@1@S@HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 123)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 139) (:start . 124) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 172) (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 181)\n  (:start . 176) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 200)\n  (:start . 191) (:id . 69))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 209)\n  (:start . 201) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 212) (:start . 210)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 224)\n  (:start . 213) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 230)\n  (:start . 225) (:id . 73))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 233) (:start . 231)\n  (:id . 74))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 238) (:start . 234)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 241) (:start . 239)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 244) (:start . 242)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 253)\n  (:start . 245) (:id . 78))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 256) (:start . 254)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 262)\n  (:start . 257) (:id . 80))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 272)\n  (:start . 263) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x725.4.1) (:span 33 36)))\n (:hscopes ((:id . :x725.4.1) (:span 33 272)))\n (:identifiers (:sid . :s725.4) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006726@unknown@formal@none@1@S@Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B.@(((:tag . "NN") (:stem . "enhancement") (:form . "Enhancement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 119)\n  (:start . 112) (:id . 57))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 136)\n  (:start . 128) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s725.5) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006727@unknown@formal@none@1@S@NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 134)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s725.6) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006728@unknown@formal@none@1@S@Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity.@(((:tag . "NN") (:stem . "phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 150)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s725.7) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006730@unknown@formal@none@1@S@Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication.@(((:tag . "JJ") (:stem . "chronic") (:form . "Chronic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intranuclear") (:form . "intranuclear") (:end . 123)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 135)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 143)\n  (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "perpetuate") (:form . "perpetuating") (:end . 159)\n  (:start . 147) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 165)\n  (:start . 160) (:id . 63))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 177)\n  (:start . 166) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s725.9) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006731@unknown@formal@none@1@S@Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "store") (:form . "stores") (:end . 30)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 113)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x725.10.1) (:span 52 55)))\n (:hscopes ((:id . :x725.10.1) (:span 52 138)))\n (:identifiers (:sid . :s725.10) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006732@unknown@formal@none@1@S@In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "sustain") (:form . "sustained") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 154)\n  (:start . 145) (:id . 64))\n ((:tag . "NNS") (:stem . "period") (:form . "periods") (:end . 162)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 180) (:start . 166) (:id . 67))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 69))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 203)\n  (:start . 195) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 208) (:start . 204)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 219)\n  (:start . 209) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s725.11) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006733@unknown@formal@none@1@S@Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals.@(((:tag . "JJ") (:stem . "elevated") (:form . "Elevated") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "serum") (:form . "sera") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 98) (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s725.12) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006734@unknown@formal@none@1@S@Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders.@(((:tag . "NN") (:stem . "secretion") (:form . "Secretion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "cell-derived") (:form . "cell-derived") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "aids-associated") (:form . "AIDS-associated")\n  (:end . 112) (:start . 97) (:id . 55))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 122)\n  (:start . 113) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x725.13.1) (:span 44 47)))\n (:hscopes ((:id . :x725.13.1) (:span 44 122)))\n (:identifiers (:sid . :s725.13) (:did . :|7565415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006735@unknown@formal@none@1@S@Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nfatp/ap-1") (:form . "NFATp/AP-1") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 147)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s726.1) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006736@unknown@formal@none@1@S@T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor mRNA levels.@(((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 26) (:start . 13) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 40)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "1,25-dihydroxyvitamin")\n  (:form . "1,25-dihydroxyvitamin") (:end . 65) (:start . 44) (:id . 47))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 68) (:start . 66)\n  (:id . 48))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 70) (:start . 69)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 81)\n  (:start . 70) (:id . 50))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 169)\n  (:start . 158) (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 171) (:start . 170)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 177) (:start . 173)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 185)\n  (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 196)\n  (:start . 186) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 224) (:start . 202) (:id . 77))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 243) (:start . 225) (:id . 78))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 250)\n  (:start . 244) (:id . 79))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 255) (:start . 251)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 262)\n  (:start . 256) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s726.2) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006737@unknown@formal@none@1@S@We report here that 1,25(OH)2D3-mediated repression in Jurkat cells is cycloheximide resistant, suggesting that it is a direct transcriptional repressive effect on IL-2 expression by the vitamin D3 receptor (VDR).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "1,25(OH)2D3-mediated")\n  (:form . "1,25(OH)2D3-mediated") (:end . 40) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 84) (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 142) (:start . 127) (:id . 61))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 153)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 160)\n  (:start . 154) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 179)\n  (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 194)\n  (:start . 187) (:id . 69))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 206)\n  (:start . 198) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 211) (:start . 208)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x726.3.1) (:span 96 106)))\n (:hscopes ((:id . :x726.3.1) (:span 96 212)))\n (:identifiers (:sid . :s726.3) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006738@unknown@formal@none@1@S@We therefore examined vitamin D3-mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "d3-mediated") (:form . "D3-mediated") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "cotransfecte") (:form . "cotransfecting")\n  (:end . 99) (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 106)\n  (:start . 100) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter/reporter") (:form . "promoter/reporter")\n  (:end . 140) (:start . 123) (:id . 58))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 151)\n  (:start . 141) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 161) (:start . 158)\n  (:id . 62))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 176) (:start . 162) (:id . 63))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 183)\n  (:start . 177) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 190) (:start . 188)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 194) (:start . 191)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 202)\n  (:start . 195) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s726.4) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006740@unknown@formal@none@1@S@VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression.@(((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 115)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 156)\n  (:start . 149) (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 160) (:start . 157)\n  (:id . 71))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 175) (:start . 172)\n  (:id . 74))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 183)\n  (:start . 176) (:id . 75))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 188) (:start . 184)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x726.6.1) (:span 172 175))\n  ((:id . :x726.6.2) (:span 29 35)))\n (:nscopes ((:id . :x726.6.1) (:span 172 199))\n  ((:id . :x726.6.2) (:span 0 94)))\n (:identifiers (:sid . :s726.6) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006741@unknown@formal@none@1@S@These results indicate that DNA binding by VDR is necessary but not sufficient to mediate IL-2 repression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x726.7.2) (:span 14 27)))\n (:ncues ((:id . :x726.7.1) (:span 64 67)))\n (:hscopes ((:id . :x726.7.2) (:span 14 105)))\n (:nscopes ((:id . :x726.7.1) (:span 64 105)))\n (:identifiers (:sid . :s726.7) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006742@unknown@formal@none@1@S@By combining partially purified proteins in vitro, we observed the loss of the bound NFATp/AP-1-DNA complex upon inclusion of VDR or VDR-retinoid X receptor.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nfatp/ap-1-dna") (:form . "NFATp/AP-1-DNA")\n  (:end . 99) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inclusion") (:form . "inclusion") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "vdr-retinoid") (:form . "VDR-retinoid") (:end . 145)\n  (:start . 133) (:id . 64))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s726.8) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006743@unknown@formal@none@1@S@Order of addition and off-rate experiments indicate that the VDR-retinoid X receptor heterodimer blocks NFATp/AP-1 complex formation and then stably associates with the NF-AT-1 element.@(((:tag . "NNP") (:stem . "Order") (:form . "Order") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "off-rate") (:form . "off-rate") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "vdr-retinoid") (:form . "VDR-retinoid") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "nfatp/ap-1") (:form . "NFATp/AP-1") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 132)\n  (:start . 123) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 59))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nf-at-1") (:form . "NF-AT-1") (:end . 176)\n  (:start . 169) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 184)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x726.9.1) (:span 43 56)))\n (:hscopes ((:id . :x726.9.1) (:span 43 184)))\n (:identifiers (:sid . :s726.9) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006744@unknown@formal@none@1@S@This direct inhibition by a nuclear hormone receptor of transcriptional activators of the IL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 71) (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mechanistic") (:form . "mechanistic") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 137)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 164)\n  (:start . 153) (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 200) (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 207)\n  (:start . 201) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x726.10.1) (:span 100 103)))\n (:hscopes ((:id . :x726.10.1) (:span 100 207)))\n (:identifiers (:sid . :s726.10) (:did . :|7565732|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006745@unknown@formal@none@1@S@An interferon-gamma activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-gamma.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 19) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 68) (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 79)\n  (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IC") (:form . "IC") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 135) (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s727.1) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006746@unknown@formal@none@1@S@Expression of the IgG Fc receptor type I (Fc gamma RI) on myeloid cells is dramatically increased by treatment with interferon-gamma (IFN-gamma).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 65)\n  (:start . 58) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 87)\n  (:start . 75) (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 97)\n  (:start . 88) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 110)\n  (:start . 101) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 132) (:start . 116) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 143)\n  (:start . 134) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s727.2) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006747@unknown@formal@none@1@S@We observed that Fc gamma RI transcript levels in monoblast-like U937 cells were elevated within 3 hr and peaked 12 hr after exposure to IFN-gamma.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monoblast-like") (:form . "monoblast-like")\n  (:end . 64) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "peak") (:form . "peaked") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 146)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s727.3) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006748@unknown@formal@none@1@S@Treatment of U937 with IFN-gamma for 9 hr in the presence of cycloheximide led to super-induction of Fc gamma RI expression.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 74) (:start . 61) (:id . 54))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "super-induction") (:form . "super-induction")\n  (:end . 97) (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s727.4) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006750@unknown@formal@none@1@S@Genomic sequence upstream of the Fc gamma RIC gene was cloned and subjected to primer extension analysis, which demonstrated a single transcription initiation site without a TATA box.@(((:tag . "JJ") (:stem . "genomic") (:form . "Genomic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RIC") (:form . "RIC") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 124)\n  (:start . 112) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 147) (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x727.6.1) (:span 164 171)))\n (:nscopes ((:id . :x727.6.1) (:span 164 182)))\n (:identifiers (:sid . :s727.6) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006751@unknown@formal@none@1@S@Transient transfections of CAT reporter gene constructs containing various Fc gamma RIC promoter sequences into U937 cells revealed that a 20-bp region surrounding the transcription start site (-7 to +13) was capable of mediating transcription initiation and that an IFN-gamma responsive element (GIRE) was present within 74 bp upstream of the transcription initiation site.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transfection") (:form . "transfections")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . 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"initiation") (:end . 368)\n  (:start . 358) (:id . 98))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 373) (:start . 369)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 374) (:start . 373)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s727.7) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006752@unknown@formal@none@1@S@A 17-bp sequence between positions -51 and -35 conferred IFN-gamma responsiveness on a heterologous promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "17-bp") (:form . "17-bp") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "CD") (:stem . "-51") (:form . "-51") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "-35") (:form . "-35") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 81) (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 99)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s727.8) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006753@unknown@formal@none@1@S@Double-stranded GIRE sequence, but not a scrambled sequence, was specifically bound by nuclear proteins from IFN-gamma treated U937 cells.@(((:tag . "JJ") (:stem . "double-stranded") (:form . "Double-stranded")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "GIRE") (:form . "GIRE") (:end . 20) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "scramble") (:form . "scrambled") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 77)\n  (:start . 65) (:id . 53))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "treated") (:form . "treated") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x727.9.1) (:span 35 38)))\n (:nscopes ((:id . :x727.9.1) (:span 35 59)))\n (:identifiers (:sid . :s727.9) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006754@unknown@formal@none@1@S@Gel shift experiments further showed that the STAT1 alpha protein bound to the Fc gamma RIC GIRE in response to IFN-gamma treatment of U937 cells.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 36) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RIC") (:form . "RIC") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GIRE") (:form . "GIRE") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s727.10) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006755@unknown@formal@none@1@S@The Fc gamma RIC GIRE is homologous to the IFN-gamma activation sequence (GAS) of the guanylate binding protein and to X box elements of class II MHC genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RIC") (:form . "RIC") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GIRE") (:form . "GIRE") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 35)\n  (:start . 25) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "guanylate") (:form . "guanylate") (:end . 95)\n  (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 133)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 142)\n  (:start . 137) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 145) (:start . 143)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 155)\n  (:start . 150) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s727.11) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006756@unknown@formal@none@1@S@Our results demonstrate that transcriptional regulation of the Fc gamma RIC gene by IFN-gamma involves the binding of STAT1 alpha to a 17-bp GAS homology in the proximal promoter.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 44) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RIC") (:form . "RIC") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "17-bp") (:form . "17-bp") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s727.12) (:did . :|7565811|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006757@unknown@formal@none@1@S@Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis [see comments]@(((:tag . "NN") (:stem . "immunosuppression") (:form . "Immunosuppression")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 36) (:start . 21) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 37) (:start . 36)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s728.1) (:did . :|7569976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006758@unknown@formal@none@1@S@Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents.@(((:tag . "NNS") (:stem . "glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 59) (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 81) (:start . 64) (:id . 50))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 88)\n  (:start . 82) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s728.2) (:did . :|7569976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006760@unknown@formal@none@1@S@Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-kappa B) activation in mice and cultured cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 37) (:start . 22) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 117)\n  (:start . 113) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s728.4) (:did . :|7569976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006761@unknown@formal@none@1@S@This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "trap") (:form . "traps") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 140)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s728.5) (:did . :|7569976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006762@unknown@formal@none@1@S@Because NF-kappa B activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 50) (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 88) (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 178) (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 187)\n  (:start . 179) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 206) (:start . 191) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x728.6.1) (:span 129 132)))\n (:hscopes ((:id . :x728.6.1) (:span 129 206)))\n (:identifiers (:sid . :s728.6) (:did . :|7569976|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006763@unknown@formal@none@1@S@Pathogenesis of atherosclerosis.@(((:tag . "NN") (:stem . "pathogenesis") (:form . "Pathogenesis") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 31) (:start . 16) (:id . 44))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 32) (:start . 31)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s729.1) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006764@unknown@formal@none@1@S@The earliest lesion in the development of an atherosclerotic plaque is the fatty streak.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "lesion") (:form . "lesion") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 60) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "plaque") (:form . "plaque") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "streak") (:form . "streak") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s729.2) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006765@unknown@formal@none@1@S@This chronic inflammatory reaction results from a sequence of events that begins with the trapping of low density lipoprotein (LDL) in the subendothelial space of the artery wall.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "begin") (:form . "begins") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "trapping") (:form . "trapping") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "subendothelial") (:form . "subendothelial")\n  (:end . 153) (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "artery") (:form . "artery") (:end . 173)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 178) (:start . 174)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s729.3) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006766@unknown@formal@none@1@S@The trapped LDL is seeded with oxidative species released by the overlying endothelium, and lipid oxidation is initiated within the LDL particle.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "trap") (:form . "trapped") (:end . 11) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "seed") (:form . "seeded") (:end . 25) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "overlie") (:form . "overlying") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "particle") (:form . "particle") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s729.4) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006767@unknown@formal@none@1@S@Some of the lipids that result lead to the activation of NFkB-like transcription factors that cause the expression of genes whose protein products mediate monocyte binding, monocyte chemotaxis into the subendothelial space, and conversion into macrophages.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lipid") (:form . "lipids") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nfkb-like") (:form . "NFkB-like") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 181)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "chemotaxis") (:form . "chemotaxis") (:end . 192)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 197) (:start . 193)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "subendothelial") (:form . "subendothelial")\n  (:end . 216) (:start . 202) (:id . 73))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 222)\n  (:start . 217) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 76))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 238)\n  (:start . 228) (:id . 77))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 243) (:start . 239)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 255)\n  (:start . 244) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s729.5) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006768@unknown@formal@none@1@S@At least 1 major gene modulates the oxidation of LDL lipids and/or the biologic response to these lipids.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lipid") (:form . "lipids") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lipid") (:form . "lipids") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s729.6) (:did . :|7572682|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006770@unknown@formal@none@1@S@HMG-I binds to GATA motifs: implications for an HPFH syndrome.@(((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HPFH") (:form . "HPFH") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s730.1) (:did . :|7575565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006771@unknown@formal@none@1@S@We have examined binding of the nuclear protein HMG-I to the human gamma-globin promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 79)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s730.2) (:did . :|7575565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006772@unknown@formal@none@1@S@We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter; this paired motif is bound by the erythroid factor GATA-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 64) (:start . 60)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 72) (:start . 68)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 79)\n  (:start . 73) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 99)\n  (:start . 87) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 114) (:start . 110)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 121)\n  (:start . 115) (:id . 65))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 127)\n  (:start . 122) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 136)\n  (:start . 131) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 153)\n  (:start . 144) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 160)\n  (:start . 154) (:id . 72))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 167)\n  (:start . 161) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s730.3) (:did . :|7575565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006773@unknown@formal@none@1@S@A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells (HPFH) and up-regulation of the gamma-globin promoter in in vitro expression assays; HMG-I does not bind to this mutant sequence.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "naturally") (:form . "naturally") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-175") (:form . "-175") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "T-C") (:form . "T-C") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . 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"NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 110)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HPFH") (:form . "HPFH") (:end . 141) (:start . 137)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 160) (:start . 147) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 180)\n  (:start . 168) (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 189)\n  (:start . 181) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 75))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 76))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 201)\n  (:start . 196) (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 212)\n  (:start . 202) (:id . 78))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 219)\n  (:start . 213) (:id . 79))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 220) (:start . 219)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 226)\n  (:start . 221) (:id . 81))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 231) (:start . 227)\n  (:id . 82))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 235) (:start . 232)\n  (:id . 83))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 240) (:start . 236)\n  (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 243) (:start . 241)\n  (:id . 85))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 248) (:start . 244)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 255)\n  (:start . 249) (:id . 87))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 264)\n  (:start . 256) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 89)))@@@1@48@((:ncues ((:id . :x730.4.1) (:span 232 235)))\n (:nscopes ((:id . :x730.4.1) (:span 232 264)))\n (:identifiers (:sid . :s730.4) (:did . :|7575565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006774@unknown@formal@none@1@S@A survey of GATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "survey") (:form . "survey") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s730.5) (:did . :|7575565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006775@unknown@formal@none@1@S@These findings implicate HMG-I in the HPFH phenotype; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "implicate") (:form . "implicate") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HPFH") (:form . "HPFH") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "speculate") (:form . "speculate") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "multiprotein") (:form . "multiprotein") (:end . 123)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 154)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 170)\n  (:start . 160) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x730.6.1) (:span 75 78)) ((:id . :x730.6.2) (:span 57 66)))\n (:hscopes ((:id . :x730.6.1) (:span 75 170))\n  ((:id . :x730.6.2) (:span 57 170)))\n (:identifiers (:sid . :s730.6) (:did . :|7575565|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006776@unknown@formal@none@1@S@The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s731.1) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006777@unknown@formal@none@1@S@MZF-1 is a C2H2 zinc finger gene encoding a putative transcriptional regulator of myeloid differentiation.@(((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c2h2") (:form . "C2H2") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 68) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 105) (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x731.2.1) (:span 44 52)))\n (:hscopes ((:id . :x731.2.1) (:span 44 105)))\n (:identifiers (:sid . :s731.2) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006778@unknown@formal@none@1@S@The MZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus, 5 through 13.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c2h2") (:form . "C2H2") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "arrange") (:form . "arranged") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "carboxy-terminus") (:form . "carboxy-terminus")\n  (:end . 152) (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s731.3) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006780@unknown@formal@none@1@S@To assess the transcription regulatory function of MZF-1, the full-length MZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 157) (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 162) (:start . 158)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s731.5) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006781@unknown@formal@none@1@S@The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3, 293, K562, and Jurkat cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 64) (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 83)\n  (:start . 72) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 137)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . "NNP") (:stem . "GAL4") (:form . "GAL4") (:end . 162) (:start . 158)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 174)\n  (:start . 167) (:id . 66))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NIH") (:form . "NIH") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . "NN") (:stem . "3t3") (:form . "3T3") (:end . 193) (:start . 190)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 198) (:start . 195)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 216)\n  (:start . 210) (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 221) (:start . 217)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 227)\n  (:start . 222) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s731.6) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006782@unknown@formal@none@1@S@MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293.@(((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 91) (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NIH") (:form . "NIH") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "3t3") (:form . "3T3") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s731.7) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006783@unknown@formal@none@1@S@In contrast, MZF-1 activates CAT reporter gene expression in the hematopoietic cell lines K562 and Jurkat.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "K562") (:form . "K562") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s731.8) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006784@unknown@formal@none@1@S@The MZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation, including the CD34 promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 110) (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s731.9) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006785@unknown@formal@none@1@S@MZF-1 transcriptional regulation of this physiologically relevant promoter was assessed in both hematopoietic and nonhematopoietic cell lines.@(((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 56) (:start . 41) (:id . 47))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 109) (:start . 96) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 130) (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 141)\n  (:start . 136) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s731.10) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006786@unknown@formal@none@1@S@Recombinant MZF-1 protein specifically binds to the consensus binding sites in the CD34 promoter in mobility shift assays.@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 44) (:start . 39)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s731.11) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006787@unknown@formal@none@1@S@MZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and hematopoietic cell lines.@(((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 139) (:start . 123) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 157) (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 168)\n  (:start . 163) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s731.12) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006788@unknown@formal@none@1@S@As with the heterologous DNA binding domain, MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 105) (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 158) (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 169)\n  (:start . 164) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s731.13) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006790@unknown@formal@none@1@S@The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd34") (:form . "CD34") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MZF-1") (:form . "MZF-1") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 104) (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "regulators/adapter")\n  (:form . "regulators/adapters") (:end . 124) (:start . 105) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 140)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 146)\n  (:start . 141) (:id . 60))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 160) (:start . 147) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "determine") (:form . "determine") (:end . 175)\n  (:start . 166) (:id . 63))\n ((:tag . "NN") (:stem . "mzf-1") (:form . "MZF-1") (:end . 181)\n  (:start . 176) (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 197) (:start . 182) (:id . 65))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 208)\n  (:start . 198) (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 217)\n  (:start . 209) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x731.15.1) (:span 125 127))\n  ((:id . :x731.15.2) (:span 64 72)))\n (:hscopes ((:id . :x731.15.1) (:span 89 160))\n  ((:id . :x731.15.2) (:span 64 217)))\n (:identifiers (:sid . :s731.15) (:did . :|7579328|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006791@unknown@formal@none@1@S@The normal cell cycle activation program is exploited during the infection of quiescent B lymphocytes by Epstein-Barr virus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "exploit") (:form . "exploited") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s732.1) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006792@unknown@formal@none@1@S@B lymphocytes in the peripheral circulation are maintained in a non-proliferative state.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "circulation") (:form . "circulation") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "non-proliferative") (:form . "non-proliferative")\n  (:end . 81) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s732.2) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006793@unknown@formal@none@1@S@Antigen recognition stimulates limited proliferation, whereas infection with Epstein-Barr virus (EBV) results in continual proliferation and the outgrowth of immortal cell lines.@(((:tag . "NN") (:stem . "antigen") (:form . "Antigen") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 52) (:start . 39) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 71)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 89)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 95) (:start . 90)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "continual") (:form . "continual") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 136) (:start . 123) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immortal") (:form . "immortal") (:end . 166)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 177)\n  (:start . 172) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s732.3) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006794@unknown@formal@none@1@S@Because it is not clear at which point in cell cycle the peripheral B lymphocytes are arrested, we characterized the expression of several cell cycle-associated genes in quiescent and stimulated cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 67)\n  (:start . 57) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 81)\n  (:start . 70) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "arrest") (:form . "arrested") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 112) (:start . 99) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cycle-associated") (:form . "cycle-associated")\n  (:end . 160) (:start . 144) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 166)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 200)\n  (:start . 195) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x732.4.1) (:span 14 23)))\n (:hscopes ((:id . :x732.4.1) (:span 14 94)))\n (:identifiers (:sid . :s732.4) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006795@unknown@formal@none@1@S@We show that the expression of four cell genes, cdc-2, cyclin E, CD23, and cyclin D2, are up-regulated approximately 100-fold as a result of EBV-mediated immortalization.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cdc-2") (:form . "cdc-2") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 61)\n  (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 69) (:start . 65)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 81)\n  (:start . 75) (:id . 60))\n ((:tag . "NN") (:stem . "d2") (:form . "D2") (:end . 84) (:start . 82)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 102)\n  (:start . 90) (:id . 64))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 116) (:start . 103) (:id . 65))\n ((:tag . "RB") (:stem . "100-fold") (:form . "100-fold") (:end . 125)\n  (:start . 117) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 68))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 137)\n  (:start . 131) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "ebv-mediated") (:form . "EBV-mediated") (:end . 153)\n  (:start . 141) (:id . 71))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 169) (:start . 154) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s732.5) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006796@unknown@formal@none@1@S@Because these genes play a positive role in cell proliferation, we suggest that this regulatory switch contributes to controlling entry into the cell cycle.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x732.6.1) (:span 67 74)))\n (:hscopes ((:id . :x732.6.1) (:span 67 155)))\n (:identifiers (:sid . :s732.6) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006797@unknown@formal@none@1@S@Transient stimulation of quiescent B lymphocytes with either a cocktail of anti-CD40, anti-IgM, and IL4, or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cocktail") (:form . "cocktail") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "anti-IgM") (:form . "anti-IgM") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "same") (:form . 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"EBV") (:end . 205) (:start . 202)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "exploit") (:form . "exploits") (:end . 214)\n  (:start . 206) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 225)\n  (:start . 219) (:id . 82))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 233)\n  (:start . 226) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 249) (:start . 237) (:id . 85))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 254) (:start . 250)\n  (:id . 86))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 260)\n  (:start . 255) (:id . 87))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 271)\n  (:start . 261) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x732.7.1) (:span 168 178)))\n (:hscopes ((:id . :x732.7.1) (:span 168 271)))\n (:identifiers (:sid . :s732.7) (:did . :|7585505|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006798@unknown@formal@none@1@S@CD30 ligation induces nuclear factor-kappa B activation in human T cell lines.@(((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s733.1) (:did . :|7589085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006800@unknown@formal@none@1@S@In this report, we show that following incubation of L540 cells (Hodgkin's disease-derived, T cell-like, CD30+ cells) with the agonistic anti-CD30 monoclonal antibodies (mAb) M44 and M67, two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts, as determined in gel retardation assays.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . 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"NN") (:stem . "factor") (:form . "factor") (:end . 206)\n  (:start . 200) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 217)\n  (:start . 208) (:id . 82))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 219) (:start . 218)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 223) (:start . 220)\n  (:id . 84))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 231)\n  (:start . 224) (:id . 85))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 242)\n  (:start . 232) (:id . 86))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 247) (:start . 243)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 255)\n  (:start . 248) (:id . 88))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 258) (:start . 256)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "nuclear") (:form . 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5006801@unknown@formal@none@1@S@The effect of the mAb towards NF-kappa B activation was rapid, as it occurred within 20 min, and was sustained for up to 6 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 110)\n  (:start . 101) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 117) (:start . 115)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 66))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 122) (:start . 121)\n  (:id . 67))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 124) (:start . 123)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s733.4) (:did . :|7589085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006802@unknown@formal@none@1@S@By comparison, an isotype-matched antibody had no effect on NF-kappa B activation.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "isotype-matched") (:form . "isotype-matched")\n  (:end . 33) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x733.5.1) (:span 47 49)))\n (:nscopes ((:id . :x733.5.1) (:span 47 81)))\n (:identifiers (:sid . :s733.5) (:did . :|7589085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006803@unknown@formal@none@1@S@Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30-mediated NF-kappa B activation correlated with the proportion of CD30+ cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Th") (:form . 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5006806@unknown@formal@none@1@S@Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "granulopoiesis") (:form . "granulopoiesis")\n  (:end . 59) (:start . 45) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "alpha-deficient") (:form . "alpha-deficient")\n  (:end . 112) (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 117)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s734.1) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006807@unknown@formal@none@1@S@Transcription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 31)\n  (:start . 22) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s734.2) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006808@unknown@formal@none@1@S@Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days.@(((:tag . "RB") (:stem . "apparently") (:form . "Apparently") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "birth") (:form . "birth") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "alpha-/-") (:form . "alpha-/-") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "runting") (:form . "runting") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 103)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "granulopoiesis") (:form . "granulopoiesis")\n  (:end . 118) (:start . 104) (:id . 61))\n ((:tag . "RB") (:stem . "postnatally") (:form . "postnatally") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "VBG") (:stem . "die") (:form . "dying") (:end . 147) (:start . 142)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s734.3) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006810@unknown@formal@none@1@S@NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 62)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 158)\n  (:start . 146) (:id . 67))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 166)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities")\n  (:end . 189) (:start . 176) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x734.5.1) (:span 76 83)))\n (:nscopes ((:id . :x734.5.1) (:span 76 138)))\n (:identifiers (:sid . :s734.5) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006811@unknown@formal@none@1@S@In contrast to hematopoietic cells, I kappa B alpha-/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "alpha-/-") (:form . "alpha-/-") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "JJ") (:stem . "signal-dependent") (:form . "signal-dependent")\n  (:end . 149) (:start . 133) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 160) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 171)\n  (:start . 161) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 176) (:start . 172)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 191)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 198) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 204)\n  (:start . 199) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 211) (:start . 207)\n  (:id . 75))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 223)\n  (:start . 212) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s734.6) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006812@unknown@formal@none@1@S@Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b") (:form . "b") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 78)\n  (:start . 70) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "signal-dependent") (:form . "signal-dependent")\n  (:end . 103) (:start . 87) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 126)\n  (:start . 118) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 143)\n  (:start . 132) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x734.7.2) (:span 12 25)))\n (:ncues ((:id . :x734.7.1) (:span 46 49)))\n (:hscopes ((:id . :x734.7.2) (:span 12 143)))\n (:nscopes ((:id . :x734.7.1) (:span 46 65)))\n (:identifiers (:sid . :s734.7) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006813@unknown@formal@none@1@S@However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "postinduction") (:form . "postinduction")\n  (:end . 58) (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s734.8) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006814@unknown@formal@none@1@S@These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 82)\n  (:start . 71) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "necessity") (:form . "necessity") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "stringent") (:form . "stringent") (:end . 110)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s734.9) (:did . :|7590249|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006815@unknown@formal@none@1@S@Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.@(((:tag . "NNP") (:stem . "Vitamin") (:form . "Vitamin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ccl4-induced") (:form . "CCl4-induced") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s735.1) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006816@unknown@formal@none@1@S@Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies.@(((:tag . "JJ") (:stem . "oxidative") (:form . "Oxidative") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "etiology") (:form . "etiologies") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x735.2.1) (:span 63 66)))\n (:hscopes ((:id . :x735.2.1) (:span 63 150)))\n (:identifiers (:sid . :s735.2) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006817@unknown@formal@none@1@S@Oxidative stress enhances nuclear factor kappa B (NF-kappa B) activity, and NF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines.@(((:tag . "JJ") (:stem . "oxidative") (:form . "Oxidative") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 121)\n  (:start . 114) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 159)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s735.3) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006818@unknown@formal@none@1@S@Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl4 in mice.@(((:tag . "JJ") (:stem . "acute") (:form . "Acute") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intraperitoneal") (:form . "intraperitoneal")\n  (:end . 104) (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ccl4") (:form . "CCl4") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 130)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s735.4) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006820@unknown@formal@none@1@S@Alpha-tocopherol treatment of the mice given the CCl4 also reduced the NF-kappa B binding to levels approaching those found in normal mice.@(((:tag . "NNP") (:stem . "Alpha-tocopherol") (:form . "Alpha-tocopherol")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ccl4") (:form . "CCl4") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "VBG") (:stem . "approach") (:form . "approaching") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 138)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s735.6) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006821@unknown@formal@none@1@S@In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in tumor necrosis factor-alpha (TNF-alpha) messenger RNA levels.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 43) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ccl4") (:form . "CCl4") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 145)\n  (:start . 133) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s735.7) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006822@unknown@formal@none@1@S@Liver specimens taken from patients with acute fulminant hepatitis had markedly increased NF-kappa B binding activity in comparison with the binding of normal livers.@(((:tag . "NN") (:stem . "liver") (:form . "Liver") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "specimen") (:form . "specimens") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fulminant") (:form . "fulminant") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "hepatitis") (:form . "hepatitis") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 158)\n  (:start . 152) (:id . 64))\n ((:tag . "NNS") (:stem . "liver") (:form . "livers") (:end . 165)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s735.8) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006823@unknown@formal@none@1@S@These data demonstrate that abolishing acute hepatic injury with alpha-tocopherol, a free radical scavenger, also eliminated increased NF-kappa B binding.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "abolish") (:form . "abolishing") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . "alpha-tocopherol")\n  (:end . 81) (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "eliminate") (:form . "eliminated") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 153)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s735.9) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006824@unknown@formal@none@1@S@It is tempting to speculate that enhanced NF-kappa B expression caused by free radical production/oxidative stress may modulate liver injury, perhaps through an effect on cytotoxic cytokine synthesis.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "tempt") (:form . "tempting") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "speculate") (:form . "speculate") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "production/oxidative")\n  (:form . "production/oxidative") (:end . 107) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 114)\n  (:start . 108) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 189)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 199)\n  (:start . 190) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x735.10.1) (:span 142 149))\n  ((:id . :x735.10.2) (:span 115 118)) ((:id . :x735.10.3) (:span 18 27)))\n (:hscopes ((:id . :x735.10.1) (:span 142 199))\n  ((:id . :x735.10.2) (:span 115 199)) ((:id . :x735.10.3) (:span 18 199)))\n (:identifiers (:sid . :s735.10) (:did . :|7590666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006825@unknown@formal@none@1@S@Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s736.1) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006826@unknown@formal@none@1@S@Critical role for IL-6.@(((:tag . "JJ") (:stem . "critical") (:form . "Critical") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 23) (:start . 22)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s736.2) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006827@unknown@formal@none@1@S@The T cell activation is initiated by interaction of specific Ags with TCR, followed by activation of intracellular biochemical events leading to activation of several genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "ag") (:form . "Ags") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 115) (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s736.3) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006828@unknown@formal@none@1@S@The activation of signal transducer and activator of transcription (STAT) proteins in a primary TCR-mediated activation of T cells have been explored.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 108)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s736.4) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006830@unknown@formal@none@1@S@These STAT proteins were detected by using the IFN-gamma-activated sequence (GAS) and related oligonucleotides as probes in electrophoretic mobility shift assay.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ifn-gamma-activated")\n  (:form . "IFN-gamma-activated") (:end . 66) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 110) (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 139) (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 148)\n  (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s736.6) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006831@unknown@formal@none@1@S@Analysis of the nuclear extracts with anti-STAT Abs indicated that they contained STAT-3 and additional proteins crossreactive with the STAT family.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-stat") (:form . "anti-STAT") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "stat-3") (:form . "STAT-3") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "crossreactive") (:form . "crossreactive")\n  (:end . 126) (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 147)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x736.7.1) (:span 52 66)))\n (:hscopes ((:id . :x736.7.1) (:span 52 147)))\n (:identifiers (:sid . :s736.7) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006832@unknown@formal@none@1@S@The induction of STAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A, thus indicating that the induction was due to a secondary factor produced by the activated T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 173)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 180)\n  (:start . 174) (:id . 69))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 189)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 192) (:start . 190)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 206)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 208) (:start . 207)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 214)\n  (:start . 209) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x736.8.1) (:span 121 136)))\n (:hscopes ((:id . :x736.8.1) (:span 121 214)))\n (:identifiers (:sid . :s736.8) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006833@unknown@formal@none@1@S@As neutralizing anti-IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR-mediated bindings, it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "anti-il-6") (:form . "anti-IL-6") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 56) (:start . 42) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"cell") (:end . 299) (:start . 295)\n  (:id . 88))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 308)\n  (:start . 300) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s736.9) (:did . :|7594456|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006834@unknown@formal@none@1@S@Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PKC-") (:form . "PKC-") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 68) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 88)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s737.1) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006835@unknown@formal@none@1@S@The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 32)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 44)\n  (:start . 33) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "synergize") (:form . "synergizes") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pkc-induced") (:form . "PKC-induced") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s737.2) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006836@unknown@formal@none@1@S@We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 151)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x737.3.1) (:span 21 28)))\n (:hscopes ((:id . :x737.3.1) (:span 21 151)))\n (:identifiers (:sid . :s737.3) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006837@unknown@formal@none@1@S@While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 94)\n  (:start . 83) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s737.4) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006838@unknown@formal@none@1@S@Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation.@(((:tag . "VBG") (:stem . "have") (:form . "Having") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ca(2+)-") (:form . "Ca(2+)-") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "accelerate") (:form . "accelerating") (:end . 89)\n  (:start . 77) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 105)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "focus") (:form . "focused") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 148)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 177) (:start . 162) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s737.5) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006840@unknown@formal@none@1@S@Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 30) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 82) (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x737.7.1) (:span 49 52)))\n (:nscopes ((:id . :x737.7.1) (:span 49 143)))\n (:identifiers (:sid . :s737.7) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006841@unknown@formal@none@1@S@Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "GF109203X") (:form . "GF109203X") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "VBZ") (:stem . "abrogate") (:form . "abrogates") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation/degradation")\n  (:form . "phosphorylation/degradation") (:end . 127) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "irrespective") (:form . "irrespective") (:end . 140)\n  (:start . 128) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 154)\n  (:start . 144) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 174) (:start . 158) (:id . 62))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 183)\n  (:start . 175) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 188) (:start . 185)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 192) (:start . 189)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 212) (:start . 197) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 69))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 228)\n  (:start . 217) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 235) (:start . 232)\n  (:id . 72))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 241)\n  (:start . 236) (:id . 73))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 249)\n  (:start . 242) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 252) (:start . 250)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 262)\n  (:start . 253) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 263) (:start . 262)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 265) (:start . 264)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "pkc-independent") (:form . "PKC-independent")\n  (:end . 281) (:start . 266) (:id . 79))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 290)\n  (:start . 282) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 291) (:start . 290)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x737.8.1) (:span 189 192)))\n (:nscopes ((:id . :x737.8.1) (:span 189 290)))\n (:identifiers (:sid . :s737.8) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006842@unknown@formal@none@1@S@Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation.@(((:tag . "JJ") (:stem . "contrary") (:form . "Contrary") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 54) (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 134) (:start . 119) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 171)\n  (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x737.9.1) (:span 89 92)))\n (:nscopes ((:id . :x737.9.1) (:span 89 134)))\n (:identifiers (:sid . :s737.9) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006843@unknown@formal@none@1@S@These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 44) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 92)\n  (:start . 81) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 105)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 123)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 135)\n  (:start . 127) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 164)\n  (:start . 157) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 197) (:start . 184) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 214)\n  (:start . 202) (:id . 71))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 223)\n  (:start . 215) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 226) (:start . 224)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 74))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 236)\n  (:start . 231) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IkB") (:form . "IkB") (:end . 243) (:start . 240)\n  (:id . 77))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 249)\n  (:start . 244) (:id . 78))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 265) (:start . 250) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 269) (:start . 266)\n  (:id . 80))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 281)\n  (:start . 270) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x737.10.1) (:span 14 27)))\n (:hscopes ((:id . :x737.10.1) (:span 14 281)))\n (:identifiers (:sid . :s737.10) (:did . :|7594468|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5006845@unknown@formal@none@1@S@Monocyte/macrophages may harbor HIV in a nonproductive fashion for prolonged periods of time.@(((:tag . "NNPS") (:stem . "Monocyte/macrophage")\n  (:form . "Monocyte/macrophages") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 24) (:start . 21)\n  (:id . 43))\n ((:tag . "VB") (:stem . "harbor") (:form . "harbor") (:end . 31)\n  (:start . 25) (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nonproductive") (:form . "nonproductive")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "period") (:form . "periods") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x738.2.1) (:span 21 24)))\n (:hscopes ((:id . :x738.2.1) (:span 21 92)))\n (:identifiers (:sid . :s738.2) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006846@unknown@formal@none@1@S@Viral gene expression may be reactivated by stimulation of the cells with LPS or cytokines such as TNF-alpha in vitro.@(((:tag . "JJ") (:stem . "viral") (:form . "Viral") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reactivate") (:form . "reactivated") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x738.3.1) (:span 22 25)))\n (:hscopes ((:id . :x738.3.1) (:span 0 117)))\n (:identifiers (:sid . :s738.3) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006847@unknown@formal@none@1@S@The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer NF-kappa B (p50/p65), which binds to a specific sequence in the HIV-long terminal repeat.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 52)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 111)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 171)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 180)\n  (:start . 172) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "hiv-long") (:form . "HIV-long") (:end . 196)\n  (:start . 188) (:id . 75))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 205)\n  (:start . 197) (:id . 76))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 212)\n  (:start . 206) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s738.4) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006848@unknown@formal@none@1@S@The present study demonstrates that triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) enhances viral replication in HIV-infected human monocytic cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "cr1") (:form . "CR1") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD35") (:form . "CD35") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CR3") (:form . "CR3") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 129)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 145)\n  (:start . 133) (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s738.5) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006850@unknown@formal@none@1@S@Stimulation of CR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released p24 Ag in cell cultures that was equivalent to that observed in control cultures triggered with LPS.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CR1") (:form . "CR1") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CR3") (:form . "CR3") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "fourfold") (:form . "fourfold") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cell-associated") (:form . "cell-associated")\n  (:end . 94) (:start . 79) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 151)\n  (:start . 141) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 179)\n  (:start . 172) (:id . 72))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 188)\n  (:start . 180) (:id . 73))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 198)\n  (:start . 189) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 203) (:start . 199)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 207) (:start . 204)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s738.7) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006851@unknown@formal@none@1@S@We further observed that stimulation of CR1 or CR3 induces the nuclear translocation of NF-kappa B p50/p65 in infected cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CR1") (:form . "CR1") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CR3") (:form . "CR3") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 84) (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s738.8) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006852@unknown@formal@none@1@S@Translocation of NF-kappa B p50/p65 was also observed following stimulation of CR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors.@(((:tag . "NNP") (:stem . "Translocation") (:form . "Translocation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CR1") (:form . "CR1") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cr3") (:form . "CR3") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "hiv-seronegative") (:form . "HIV-seronegative")\n  (:end . 152) (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 159)\n  (:start . 153) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s738.9) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006853@unknown@formal@none@1@S@The amount of protein translocated was similar to that observed when cells were stimulated with rhTNF-alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rhtnf-alpha") (:form . "rhTNF-alpha") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s738.10) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006854@unknown@formal@none@1@S@TNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of complement receptors.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x738.11.1) (:span 14 17)))\n (:nscopes ((:id . :x738.11.1) (:span 14 111)))\n (:identifiers (:sid . :s738.11) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006855@unknown@formal@none@1@S@Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor-mediated nuclear translocation of the NF-kappa B complex.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 126)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "complement-opsonized")\n  (:form . "complement-opsonized") (:end . 165) (:start . 145) (:id . 64))\n ((:tag . "NNS") (:stem . "particle") (:form . "particles") (:end . 175)\n  (:start . 166) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 193)\n  (:start . 185) (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 199)\n  (:start . 194) (:id . 69))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 211)\n  (:start . 200) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 214) (:start . 212)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 225)\n  (:start . 215) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 230) (:start . 226)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c3") (:form . "C3") (:end . 233) (:start . 231)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "receptor-mediated") (:form . "receptor-mediated")\n  (:end . 251) (:start . 234) (:id . 75))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 259)\n  (:start . 252) (:id . 76))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 273) (:start . 260) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 276) (:start . 274)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 280) (:start . 277)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 289)\n  (:start . 281) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 291) (:start . 290)\n  (:id . 81))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 299)\n  (:start . 292) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 300) (:start . 299)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x738.12.1) (:span 68 71))\n  ((:id . :x738.12.2) (:span 35 42)))\n (:hscopes ((:id . :x738.12.1) (:span 68 175))\n  ((:id . :x738.12.2) (:span 35 299)))\n (:identifiers (:sid . :s738.12) (:did . :|7594489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006856@unknown@formal@none@1@S@Nuclear factor-IL6 activates the human IL-4 promoter in T cells.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-il6") (:form . "factor-IL6") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s739.1) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006857@unknown@formal@none@1@S@Positive regulatory element I (PRE-I) is a strong enhancer element essential for expression of the human IL-4 gene.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s739.2) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006858@unknown@formal@none@1@S@To identify transcription factors binding to PRE-I, we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "screen") (:form . "screened") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF)-IL6") (:form . "NF)-IL6") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 183)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s739.3) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006860@unknown@formal@none@1@S@rNF-IL6 expressed in bacteria was shown to specifically bind to PRE-I.@(((:tag . "NN") (:stem . "rnf-il6") (:form . "rNF-IL6") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s739.5) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006861@unknown@formal@none@1@S@PRE-I forms multiple DNA-protein complexes with nuclear extracts from Jurkat cells.@(((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s739.6) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006862@unknown@formal@none@1@S@Some of these complexes were demonstrated to contain NF-IL6 by using anti-C/EBP beta Abs.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "nf-il6") (:form . "NF-IL6") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-c/ebp") (:form . "anti-C/EBP") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s739.7) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006863@unknown@formal@none@1@S@Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I-thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 86)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 95)\n  (:start . 87) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 107)\n  (:start . 101) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PRE-I-thymidine") (:form . "PRE-I-thymidine")\n  (:end . 130) (:start . 115) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 137)\n  (:start . 131) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 150)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 155) (:start . 151)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 174) (:start . 170)\n  (:id . 65))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 182)\n  (:start . 175) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 192)\n  (:start . 186) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 198)\n  (:start . 193) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s739.8) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006864@unknown@formal@none@1@S@Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 (C/EBP proximal) and -87 to -79 (C/EBP medial), respectively.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "nf-il6") (:form . "NF-IL6") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "CD") (:stem . "-44") (:form . "-44") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-36") (:form . "-36") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "proximal") (:form . "proximal") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-87") (:form . "-87") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-79") (:form . "-79") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "medial") (:form . "medial") (:end . 148)\n  (:start . 142) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 69))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 163)\n  (:start . 151) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s739.9) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006865@unknown@formal@none@1@S@Our results demonstrate that NF-IL6 is involved in transcriptional activation of the human IL-4 promoter in T cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 66) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s739.10) (:did . :|7594540|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006866@unknown@formal@none@1@S@Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 58) (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 77) (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 93)\n  (:start . 85) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "aml1-related") (:form . "AML1-related") (:end . 118)\n  (:start . 106) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 139)\n  (:start . 133) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PEBP2") (:form . "PEBP2") (:end . 146)\n  (:start . 141) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s740.1) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006867@unknown@formal@none@1@S@The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 26) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 45) (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 60)\n  (:start . 54) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 84)\n  (:start . 76) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 105)\n  (:start . 97) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "polyomavirus") (:form . "polyomavirus") (:end . 126)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 135)\n  (:start . 127) (:id . 58))\n ((:tag . "NN") (:stem . "binding-protein") (:form . "binding-protein")\n  (:end . 151) (:start . 136) (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 153) (:start . 152)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 160)\n  (:start . 155) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 182)\n  (:start . 176) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 189)\n  (:start . 184) (:id . 67))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 198)\n  (:start . 190) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 69))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 207)\n  (:start . 202) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 71))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 216) (:start . 212)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 225)\n  (:start . 217) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s740.2) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006868@unknown@formal@none@1@S@There are at least two genes, alpha A and alpha B, encoding the alpha subunit.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 47) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 59)\n  (:start . 51) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 69) (:start . 64)\n  (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 77)\n  (:start . 70) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s740.3) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006870@unknown@formal@none@1@S@We examined alpha A1 (an alpha A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers) for their effects on the GM-CSF promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "a1") (:form . "A1") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "a-gene") (:form . "A-gene") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 69) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 77) (:start . 74)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 83) (:start . 78)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "b-encoded") (:form . "B-encoded") (:end . 93)\n  (:start . 84) (:id . 61))\n ((:tag . "NNS") (:stem . "isomer") (:form . "isomers") (:end . 101)\n  (:start . 94) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 112)\n  (:start . 107) (:id . 65))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 120)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 123) (:start . 121)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 134)\n  (:start . 128) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 143)\n  (:start . 135) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s740.5) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006871@unknown@formal@none@1@S@PEBP2 alpha A1, alpha B1, and alpha B2 proteins bound the PEBP2 site within the mouse GM-CSF promoter.@(((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "a1") (:form . "A1") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 35) (:start . 30)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 38) (:start . 36)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 52))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 68) (:start . 64)\n  (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 75)\n  (:start . 69) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 85) (:start . 80)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 92)\n  (:start . 86) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s740.6) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006872@unknown@formal@none@1@S@PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.@(((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "a1") (:form . "A1") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "promoter-driven") (:form . "promoter-driven")\n  (:end . 81) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 114)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "12-o-tetradecanoylphorbol")\n  (:form . "12-O-tetradecanoylphorbol") (:end . 144) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "13-acetate/phytohemagglutinin-stimulated")\n  (:form . "13-acetate/phytohemagglutinin-stimulated") (:end . 185)\n  (:start . 145) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 191)\n  (:start . 186) (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 198)\n  (:start . 192) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 200) (:start . 199)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 206)\n  (:start . 201) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s740.7) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006873@unknown@formal@none@1@S@In contrast, the promoter activity was suppressed by alpha B2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s740.8) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006874@unknown@formal@none@1@S@Coexpression of alpha B1 and alpha B2 showed that the promoter activity could be determined by the alpha B1/alpha B2 ratio.@(((:tag . "NN") (:stem . "coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 44) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B1/alpha") (:form . "B1/alpha") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s740.9) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006875@unknown@formal@none@1@S@Jurkat cell extract contained PEBP2 site-binding protein(s) that cross-reacted with antimouse alpha A1 antibodies.@(((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "site-binding") (:form . "site-binding") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "protein(s)") (:form . "protein(s)") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "cross-reacte") (:form . "cross-reacted")\n  (:end . 78) (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "antimouse") (:form . "antimouse") (:end . 93)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . "NN") (:stem . "a1") (:form . "A1") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s740.10) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006876@unknown@formal@none@1@S@Northern blot analysis indicated the expression of human PEBP2 alpha A, alpha B (AML1), and beta genes in Jurkat cells.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 102) (:start . 97)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 112)\n  (:start . 106) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s740.11) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006877@unknown@formal@none@1@S@Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 155)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 177)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 190)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 196)\n  (:start . 191) (:id . 72))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 205)\n  (:start . 197) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 219)\n  (:start . 209) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 230)\n  (:start . 224) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 79))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 246)\n  (:start . 238) (:id . 80))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 255)\n  (:start . 247) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x740.12.1) (:span 131 140)))\n (:hscopes ((:id . :x740.12.1) (:span 131 255)))\n (:identifiers (:sid . :s740.12) (:did . :|7605990|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006878@unknown@formal@none@1@S@The peri-kappa B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "peri-kappa") (:form . "peri-kappa") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 53) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x741.1.1) (:span 104 107)))\n (:nscopes ((:id . :x741.1.1) (:span 104 118)))\n (:identifiers (:sid . :s741.1) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006880@unknown@formal@none@1@S@HIV-1 and HIV-2 display significant differences in nucleic acid sequence and in the natural history of clinical disease.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-2") (:form . "HIV-2") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nucleic") (:form . "nucleic") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "history") (:form . "history") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s741.3) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006881@unknown@formal@none@1@S@Consistent with these differences, we have previously demonstrated that the enhancer/promoter region of HIV-2 functions quite differently from that of HIV-1.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer/promoter") (:form . "enhancer/promoter")\n  (:end . 93) (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 100)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 125)\n  (:start . 120) (:id . 58))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 137)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 156)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s741.4) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006882@unknown@formal@none@1@S@Whereas activation of the HIV-1 enhancer following T-cell stimulation is mediated largely through binding of the transcription factor NF-kappa B to two adjacent kappa B sites in the HIV-1 long terminal repeat, activation of the HIV-2 enhancer in monocytes and T cells is dependent on four cis-acting elements: a single kappa B site, two purine-rich binding sites, PuB1 and PuB2, and a pets site.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . 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"on") (:end . 283) (:start . 281)\n  (:id . 87))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 288) (:start . 284)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 299)\n  (:start . 289) (:id . 89))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 308)\n  (:start . 300) (:id . 90))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 309) (:start . 308)\n  (:id . 91))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 311) (:start . 310)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 318)\n  (:start . 312) (:id . 93))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 324)\n  (:start . 319) (:id . 94))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 326) (:start . 325)\n  (:id . 95))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 331) (:start . 327)\n  (:id . 96))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 332) (:start . 331)\n  (:id . 97))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 336) (:start . 333)\n  (:id . 98))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 348)\n  (:start . 337) (:id . 99))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 356)\n  (:start . 349) (:id . 100))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 362)\n  (:start . 357) (:id . 101))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 363) (:start . 362)\n  (:id . 102))\n ((:tag . "NN") (:stem . "pub1") (:form . "PuB1") (:end . 368) (:start . 364)\n  (:id . 103))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 372) (:start . 369)\n  (:id . 104))\n ((:tag . "NN") (:stem . "pub2") (:form . "PuB2") (:end . 377) (:start . 373)\n  (:id . 105))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 378) (:start . 377)\n  (:id . 106))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 382) (:start . 379)\n  (:id . 107))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 384) (:start . 383)\n  (:id . 108))\n ((:tag . "NNS") (:stem . "pet") (:form . "pets") (:end . 389) (:start . 385)\n  (:id . 109))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 394) (:start . 390)\n  (:id . 110))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 395) (:start . 394)\n  (:id . 111)))@@@1@70@((:identifiers (:sid . :s741.5) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006883@unknown@formal@none@1@S@We have now identified a novel cis-acting element within the HIV-2 enhancer, immediately upstream of the kappa B site, designated peri-kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "peri-kappa") (:form . "peri-kappa") (:end . 140)\n  (:start . 130) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s741.6) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006884@unknown@formal@none@1@S@This site is conserved among isolates of HIV-2 and the closely related simian immunodeficiency virus, and transfection assays show this site to mediate HIV-2 enhancer activation following stimulation of monocytic but not T-cell lines.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 94) (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 118)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 166)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 177)\n  (:start . 167) (:id . 68))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 187)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 199)\n  (:start . 188) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 212)\n  (:start . 203) (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 216) (:start . 213)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 220) (:start . 217)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 227)\n  (:start . 221) (:id . 75))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 233)\n  (:start . 228) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x741.7.1) (:span 217 220)))\n (:nscopes ((:id . :x741.7.1) (:span 217 233)))\n (:identifiers (:sid . :s741.7) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006885@unknown@formal@none@1@S@This is the first description of an HIV-2 enhancer element which displays such monocyte specificity, and no comparable enhancer element has been clearly defined for HIV-1.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "description") (:form . "description") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hiv-2") (:form . "HIV-2") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x741.8.1) (:span 105 107)))\n (:nscopes ((:id . :x741.8.1) (:span 105 170)))\n (:identifiers (:sid . :s741.8) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006886@unknown@formal@none@1@S@While a nuclear factor(s) from both peripheral blood monocytes and T cells binds the peri-kappa B site, electrophoretic mobility shift assays suggest that either a different protein binds to this site in monocytes versus T cells or that the protein recognizing this enhancer element undergoes differential modification in monocytes and T cells, thus supporting the transfection data.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "factor(s)") (:form . "factor(s)") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . 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"site") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 119) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 141)\n  (:start . 135) (:id . 63))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 161)\n  (:start . 155) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "different") (:form . 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5006887@unknown@formal@none@1@S@Further, while specific constitutive binding to the peri-kappa B site is seen in monocytes, stimulation with phorbol esters induces additional, specific binding.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "peri-kappa") (:form . "peri-kappa") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s741.10) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006888@unknown@formal@none@1@S@Understanding the monocyte-specific function of the peri-kappa B factor may ultimately provide insight into the different role monocytes and T cells play in HIV pathogenesis.@(((:tag . "VBG") (:stem . "understand") (:form . "Understanding") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monocyte-specific") (:form . "monocyte-specific")\n  (:end . 35) (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 44)\n  (:start . 36) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "peri-kappa") (:form . "peri-kappa") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 94)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 136)\n  (:start . 127) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 173)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x741.11.1) (:span 72 75)))\n (:hscopes ((:id . :x741.11.1) (:span 72 173)))\n (:identifiers (:sid . :s741.11) (:did . :|7609053|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006890@unknown@formal@none@1@S@Thapsigargin (TG), an inhibitor of Ca(2+)-ATPase, depletes intracellular Ca2+ stores and induces a sustained Ca2+ influx without altering phosphatidyl inositol levels.@(((:tag . "NNP") (:stem . "Thapsigargin") (:form . "Thapsigargin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ca(2+)-ATPase") (:form . "Ca(2+)-ATPase")\n  (:end . 48) (:start . 35) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "deplete") (:form . "depletes") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 72) (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "store") (:form . "stores") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "phosphatidyl") (:form . "phosphatidyl") (:end . 150)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 166)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x742.2.1) (:span 121 128)))\n (:nscopes ((:id . :x742.2.1) (:span 121 166)))\n (:identifiers (:sid . :s742.2) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006891@unknown@formal@none@1@S@TG plus phorbol myristate acetate (PMA) but not TG alone induced IL-2 in Jurkat T cells, suggesting that TG had no effect on protein kinase C (PKC).@(((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tg") (:form . "TG") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 79)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 99)\n  (:start . 89) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 111) (:start . 108)\n  (:id . 64))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 114) (:start . 112)\n  (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 121)\n  (:start . 115) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 132)\n  (:start . 125) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 139)\n  (:start . 133) (:id . 69))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 141) (:start . 140)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 146) (:start . 143)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x742.3.2) (:span 89 99)))\n (:ncues ((:id . :x742.3.1) (:span 112 114))\n  ((:id . :x742.3.3) (:span 44 47)))\n (:hscopes ((:id . :x742.3.2) (:span 89 147)))\n (:nscopes ((:id . :x742.3.1) (:span 112 147))\n  ((:id . :x742.3.3) (:span 44 56)))\n (:identifiers (:sid . :s742.3) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006892@unknown@formal@none@1@S@However, TG induced increases in IL-2R alpha protein as well as IL-2R alpha mRNA in Jurkat T cells in a dose-dependent manner.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 118) (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s742.4) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006893@unknown@formal@none@1@S@A similar increase in IL-2R alpha by TG was also observed in human peripheral T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 77)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s742.5) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006894@unknown@formal@none@1@S@Further, like PMA, TG markedly induced NF kappa B in Jurkat T cells.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 30)\n  (:start . 22) (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 59)\n  (:start . 53) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s742.6) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006895@unknown@formal@none@1@S@However, TG and PMA exhibited a synergistic action on IL-2R alpha expression, suggesting that TG and PMA induce IL-2R alpha through distinct pathways.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 43)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x742.7.1) (:span 78 88)))\n (:hscopes ((:id . :x742.7.1) (:span 78 149)))\n (:identifiers (:sid . :s742.7) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006896@unknown@formal@none@1@S@PMA- but not TG-induced IL-2R alpha is inhibited by the PKC inhibitor H7, whereas TG- but not PMA-induced IL-2R alpha was inhibited by cholera toxin, forskolin and 1,9-dideoxy forskolin.@(((:tag . "NNP") (:stem . "PMA-") (:form . "PMA-") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "tg-induced") (:form . "TG-induced") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "h7") (:form . "H7") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NNP") (:stem . "TG-") (:form . "TG-") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 131)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cholera") (:form . "cholera") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "forskolin") (:form . "forskolin") (:end . 159)\n  (:start . 150) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "1,9-dideoxy") (:form . "1,9-dideoxy") (:end . 175)\n  (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "forskolin") (:form . "forskolin") (:end . 185)\n  (:start . 176) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x742.8.1) (:span 90 93)) ((:id . :x742.8.2) (:span 9 12)))\n (:nscopes ((:id . :x742.8.1) (:span 90 117))\n  ((:id . :x742.8.2) (:span 9 35)))\n (:identifiers (:sid . :s742.8) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006897@unknown@formal@none@1@S@In toto, these results suggest that TG induces IL-2R alpha in human T cells through a PKC-independent pathway.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "toto") (:form . "toto") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TG") (:form . "TG") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pkc-independent") (:form . "PKC-independent")\n  (:end . 101) (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x742.9.1) (:span 23 30)))\n (:hscopes ((:id . :x742.9.1) (:span 23 109)))\n (:identifiers (:sid . :s742.9) (:did . :|7622191|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006898@unknown@formal@none@1@S@A functional T-cell receptor signaling pathway is required for p95vav activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s743.1) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006900@unknown@formal@none@1@S@One substrate is p95vav, which is expressed exclusively in hematopoietic and trophoblast cells.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "trophoblast") (:form . "trophoblast") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s743.3) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006901@unknown@formal@none@1@S@It contains a number of structural motifs, including Src homology 2, Src homology 3, and pleckstrin homology domains and a putative guanine nucleotide exchange domain.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NNP") (:stem . "Src") (:form . "Src") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Src") (:form . "Src") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pleckstrin") (:form . "pleckstrin") (:end . 99)\n  (:start . 89) (:id . 60))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 131)\n  (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 150)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s743.4) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006902@unknown@formal@none@1@S@The role of p95vav in TCR-mediated signaling processes is unclear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x743.5.1) (:span 58 65)))\n (:hscopes ((:id . :x743.5.1) (:span 0 65)))\n (:identifiers (:sid . :s743.5) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006903@unknown@formal@none@1@S@Here, we show that overexpression of p95vav alone in Jurkat T cells leads to activation of the nuclear factors, including NFAT, involved in interleukin-2 expression.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 33) (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 121)\n  (:start . 112) (:id . 63))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 153) (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 164)\n  (:start . 154) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s743.6) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006904@unknown@formal@none@1@S@Furthermore, p95vav synergizes with TCR stimulation in inducing NFAT- and interleukin-2-dependent transcription.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "synergize") (:form . "synergizes") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "nfat-") (:form . "NFAT-") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "interleukin-2-dependent")\n  (:form . "interleukin-2-dependent") (:end . 97) (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s743.7) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006905@unknown@formal@none@1@S@In contrast, NFAT activation by a G-protein-coupled receptor is not modulated by p95vav overexpression, suggesting that the effect is specific to the TCR signaling pathways.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "g-protein-coupled") (:form . "G-protein-coupled")\n  (:end . 51) (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 102) (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x743.8.1) (:span 104 114)))\n (:ncues ((:id . :x743.8.2) (:span 64 67)))\n (:hscopes ((:id . :x743.8.1) (:span 104 172)))\n (:nscopes ((:id . :x743.8.2) (:span 13 102)))\n (:identifiers (:sid . :s743.8) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006906@unknown@formal@none@1@S@Although removal of the first 67 amino acids of p95vav activates its transforming potential in NIH 3T3 cells, this region appears to be required for its function in T cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "67") (:form . "67") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "p95vav") (:form . "p95vav") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transforming") (:form . "transforming") (:end . 81)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NIH") (:form . "NIH") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "3t3") (:form . "3T3") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x743.9.1) (:span 122 129)))\n (:hscopes ((:id . :x743.9.1) (:span 110 172)))\n (:identifiers (:sid . :s743.9) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006907@unknown@formal@none@1@S@We further demonstrate that the p95vav-induced NFAT activation is not mimicked by Ras activation, though its function is dependent upon Ras and Raf.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "p95vav-induced") (:form . "p95vav-induced")\n  (:end . 46) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mimic") (:form . "mimicked") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Raf") (:form . "Raf") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x743.10.1) (:span 66 69)))\n (:nscopes ((:id . :x743.10.1) (:span 28 96)))\n (:identifiers (:sid . :s743.10) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006908@unknown@formal@none@1@S@Furthermore, the activating function of p95vav is blocked by FK506, suggesting that its activity also depends on calcineurin.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "p95vav") (:form . "p95vav") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x743.11.1) (:span 68 78)))\n (:hscopes ((:id . :x743.11.1) (:span 68 124)))\n (:identifiers (:sid . :s743.11) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006910@unknown@formal@none@1@S@However, overexpression of p95vav does not appear to influence TCR-induced protein tyrosine phosphorylation or increases in cytoplasmic free calcium.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "p95vav") (:form . "p95vav") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "tcr-induced") (:form . "TCR-induced") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 107) (:start . 92) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 135)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 140) (:start . 136)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 148)\n  (:start . 141) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x743.13.2) (:span 43 49)))\n (:ncues ((:id . :x743.13.1) (:span 39 42)))\n (:hscopes ((:id . :x743.13.2) (:span 9 148)))\n (:nscopes ((:id . :x743.13.1) (:span 9 148)))\n (:identifiers (:sid . :s743.13) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006911@unknown@formal@none@1@S@Taken together, our data suggest that p95vav plays an important role at an yet unidentified proximal position in the TCR signaling cascade.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p95vav") (:form . "p95vav") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x743.14.1) (:span 25 32)))\n (:hscopes ((:id . :x743.14.1) (:span 25 138)))\n (:identifiers (:sid . :s743.14) (:did . :|7623828|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006912@unknown@formal@none@1@S@Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 79) (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "2a-sensitive") (:form . "2A-sensitive") (:end . 126)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s744.1) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006913@unknown@formal@none@1@S@Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 81) (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 108)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 167)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 177)\n  (:start . 168) (:id . 68))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 193)\n  (:start . 186) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x744.2.1) (:span 186 193)))\n (:hscopes ((:id . :x744.2.1) (:span 153 193)))\n (:identifiers (:sid . :s744.2) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006914@unknown@formal@none@1@S@In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 50) (:start . 34) (:id . 50))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 63)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 116) (:start . 101) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 133)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s744.3) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006915@unknown@formal@none@1@S@Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . 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"alpha") (:end . 258)\n  (:start . 253) (:id . 90))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 263) (:start . 259)\n  (:id . 91))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 266) (:start . 264)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 270) (:start . 267)\n  (:id . 93))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 278)\n  (:start . 271) (:id . 94))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 281) (:start . 279)\n  (:id . 95))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 285) (:start . 282)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 294)\n  (:start . 286) (:id . 97))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 303)\n  (:start . 295) (:id . 98))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5006916@unknown@formal@none@1@S@This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RelA.p50") (:form . "RelA.p50") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 173)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 184)\n  (:start . 179) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 192)\n  (:start . 187) (:id . 75))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 208) (:start . 193) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 211) (:start . 209)\n  (:id . 77))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 217)\n  (:start . 212) (:id . 78))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 226)\n  (:start . 218) (:id . 79))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 233)\n  (:start . 227) (:id . 80))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 239)\n  (:start . 234) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 241) (:start . 240)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 250)\n  (:start . 241) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x744.5.1) (:span 126 129)))\n (:nscopes ((:id . :x744.5.1) (:span 0 251)))\n (:identifiers (:sid . :s744.5) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006917@unknown@formal@none@1@S@Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . 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"suggesting") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 182)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "fundamental") (:form . "fundamental") (:end . 197)\n  (:start . 186) (:id . 73))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 209)\n  (:start . 198) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 232) (:start . 217) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 78))\n ((:tag . "NN") (:stem . "i") (:form . 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"B") (:end . 291) (:start . 290)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 300)\n  (:start . 292) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x744.6.1) (:span 158 168)))\n (:ncues ((:id . :x744.6.2) (:span 84 87)))\n (:hscopes ((:id . :x744.6.1) (:span 158 300)))\n (:nscopes ((:id . :x744.6.2) (:span 84 124)))\n (:identifiers (:sid . :s744.6) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006918@unknown@formal@none@1@S@However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 53) (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s744.7) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006920@unknown@formal@none@1@S@Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 52) (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "tnf-alpha-inducible")\n  (:form . "TNF-alpha-inducible") (:end . 118) (:start . 99) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pp-2a-opposing") (:form . "PP-2A-opposing")\n  (:end . 141) (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 160)\n  (:start . 155) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "proteasome-mediated")\n  (:form . "proteasome-mediated") (:end . 210) (:start . 191) (:id . 74))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 222)\n  (:start . 211) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x744.9.1) (:span 151 154))\n  ((:id . :x744.9.2) (:span 24 31)))\n (:hscopes ((:id . :x744.9.1) (:span 151 222))\n  ((:id . :x744.9.2) (:span 24 222)))\n (:identifiers (:sid . :s744.9) (:did . :|7629157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006921@unknown@formal@none@1@S@Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "i/y") (:form . "I/Y") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s745.1) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006922@unknown@formal@none@1@S@The class II major histocompatibility complex gene HLA-DRA is expressed in B cells, activated T lymphocytes, and in antigen-presenting cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 37) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 134) (:start . 116) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s745.2) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006923@unknown@formal@none@1@S@In addition, HLA-DRA gene expression is inducible in a variety of cell types by interferon-gamma (IFN-gamma).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 96) (:start . 80) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s745.3) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006924@unknown@formal@none@1@S@Here we show that the lymphoid-specific transcription factor Oct-2A plays a critical role in HLA-DRA gene expression in class II-positive B cell lines, and that the high mobility group protein (HMG) I/Y binds to multiple sites within the DRA promoter, including the Oct-2A binding site.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 39) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . 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"the") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 184)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 192)\n  (:start . 185) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 198) (:start . 197)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "I/Y") (:form . "I/Y") (:end . 202) (:start . 199)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 208)\n  (:start . 203) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 220)\n  (:start . 212) (:id . 79))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 226)\n  (:start . 221) (:id . 80))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 233)\n  (:start . 227) (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 241) (:start . 238)\n  (:id . 83))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 250)\n  (:start . 242) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 251) (:start . 250)\n  (:id . 85))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 261)\n  (:start . 252) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 265) (:start . 262)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 272)\n  (:start . 266) (:id . 88))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 280)\n  (:start . 273) (:id . 89))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 285) (:start . 281)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s745.4) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006925@unknown@formal@none@1@S@Coexpression of HMG I/Y and Oct-2 in cell lines lacking Oct-2 results in high levels of HLA-DRA gene expression, and in vitro DNA-binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter.@(((:tag . "NNP") (:stem . "Coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "I/Y") (:form . "I/Y") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 137)\n  (:start . 126) (:id . 65))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 152)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "I/Y") (:form . "I/Y") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 176)\n  (:start . 166) (:id . 71))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 183)\n  (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 191)\n  (:start . 184) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 206)\n  (:start . 199) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 215)\n  (:start . 207) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x745.5.1) (:span 48 55)))\n (:nscopes ((:id . :x745.5.1) (:span 48 61)))\n (:identifiers (:sid . :s745.5) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006926@unknown@formal@none@1@S@Thus, Oct-2A and HMG I/Y may synergize to activate HLA-DRA expression in B cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 12)\n  (:start . 6) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "I/Y") (:form . "I/Y") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x745.6.1) (:span 25 28)))\n (:hscopes ((:id . :x745.6.1) (:span 25 80)))\n (:identifiers (:sid . :s745.6) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006927@unknown@formal@none@1@S@By contrast, Oct-2A is not involved in the IFN-gamma induction of the HLA-DRA gene in HeLa cells, but antisense HMG I/Y dramatically decreases the level of induction.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Oct-2A") (:form . "Oct-2A") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 111)\n  (:start . 102) (:id . 62))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "I/Y") (:form . "I/Y") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 132)\n  (:start . 120) (:id . 65))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 165)\n  (:start . 156) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x745.7.1) (:span 23 26)))\n (:nscopes ((:id . :x745.7.1) (:span 23 96)))\n (:identifiers (:sid . :s745.7) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006928@unknown@formal@none@1@S@We conclude that distinct sets of transcription factors are involved in the two modes of HLA-DRA expression, and that HMG I/Y may be important for B cell-specific expression, and is essential for IFN-gamma induction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mode") (:form . "modes") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HMG") (:form . "HMG") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "I/Y") (:form . "I/Y") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 162) (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 205)\n  (:start . 196) (:id . 76))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 215)\n  (:start . 206) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x745.8.1) (:span 126 129)))\n (:hscopes ((:id . :x745.8.1) (:span 126 173)))\n (:identifiers (:sid . :s745.8) (:did . :|7629508|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006930@unknown@formal@none@1@S@Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "stat") (:form . "Stat") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s746.2) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006931@unknown@formal@none@1@S@Germ line C transcripts can be induced by IL-4 in the human B cell line, BL-2.@(((:tag . "NN") (:stem . "germ") (:form . "Germ") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bl-2") (:form . "BL-2") (:end . 77) (:start . 73)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s746.3) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006932@unknown@formal@none@1@S@Utilizing a IFN-gamma activation site-like DNA sequence element located upstream of the I epsilon exon, we demonstrated by gel mobility shift assays that IL-4 induced a binding activity in the cytosol and nucleus of BL-2 cells.@(((:tag . "VBG") (:stem . "utilize") (:form . "Utilizing") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "site-like") (:form . "site-like") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 119)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 166)\n  (:start . 159) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 176)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 185)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 200)\n  (:start . 193) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 212)\n  (:start . 205) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "bl-2") (:form . "BL-2") (:end . 220) (:start . 216)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s746.4) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006933@unknown@formal@none@1@S@This factor was designated IL-4 NAF (IL-4-induced nuclear-activating factors) and was identified as a tyrosine phosphoprotein, which translocates from the cytosol to the nucleus upon IL-4 treatment.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NAF") (:form . "NAF") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 49)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear-activating") (:form . "nuclear-activating")\n  (:end . 68) (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 125) (:start . 111) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "VBZ") (:stem . "translocate") (:form . "translocates") (:end . 145)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 162)\n  (:start . 155) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 197)\n  (:start . 188) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s746.5) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006934@unknown@formal@none@1@S@Because these are the characteristics of a signal transducer and activator of transcription (Stat) protein, we determined whether antibodies to Stat proteins will interfere with gel mobility shift and found that antibodies to IL-4 Stat, also known as Stat6, but not antibodies to other Stat proteins, interfere with the formation of the IL-4 NAF complex.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . 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"protein") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 162) (:start . 158)\n  (:id . 67))\n ((:tag . "VB") (:stem . "interfere") (:form . 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"IL-4") (:end . 230) (:start . 226)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 235) (:start . 231)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 236) (:start . 235)\n  (:id . 80))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 241) (:start . 237)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 247)\n  (:start . 242) (:id . 82))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 250) (:start . 248)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 256)\n  (:start . 251) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 257) (:start . 256)\n  (:id . 85))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 261) (:start . 258)\n  (:id . 86))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 265) (:start . 262)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 276)\n  (:start . 266) (:id . 88))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 279) (:start . 277)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 285)\n  (:start . 280) (:id . 90))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 290) (:start . 286)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 299)\n  (:start . 291) (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 300) (:start . 299)\n  (:id . 93))\n ((:tag . "VBP") (:stem . "interfere") (:form . "interfere") (:end . 310)\n  (:start . 301) (:id . 94))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 315) (:start . 311)\n  (:id . 95))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 319) (:start . 316)\n  (:id . 96))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 329)\n  (:start . 320) (:id . 97))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 332) (:start . 330)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 336) (:start . 333)\n  (:id . 99))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 341) (:start . 337)\n  (:id . 100))\n ((:tag . "NN") (:stem . "naf") (:form . "NAF") (:end . 345) (:start . 342)\n  (:id . 101))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 353)\n  (:start . 346) (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 354) (:start . 353)\n  (:id . 103)))@@@1@62@((:hcues ((:id . :x746.6.2) (:span 122 129)))\n (:ncues ((:id . :x746.6.1) (:span 262 265)))\n (:hscopes ((:id . :x746.6.2) (:span 122 196)))\n (:nscopes ((:id . :x746.6.1) (:span 262 299)))\n (:identifiers (:sid . :s746.6) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006935@unknown@formal@none@1@S@Congruous with the involvement of a Stat protein, IL-4 induced robust Janus kinase 3 (JAK3) activity in BL-2 cells.@(((:tag . "JJ") (:stem . "congruous") (:form . "Congruous") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "robust") (:form . "robust") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bl-2") (:form . "BL-2") (:end . 108) (:start . 104)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s746.7) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006936@unknown@formal@none@1@S@Cotransfection of JAK3 with IL-4 Stat into COS-7 cells produced an intracellular activity which bound the same IFN-gamma activation site-like sequence and comigrated with IL-4 NAF in electrophoretic mobility shift assay.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "COS-7") (:form . "COS-7") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "JJ") (:stem . "site-like") (:form . "site-like") (:end . 141)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 150)\n  (:start . 142) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "comigrate") (:form . "comigrated") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "naf") (:form . "NAF") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 198) (:start . 183) (:id . 69))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 207)\n  (:start . 199) (:id . 70))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 213)\n  (:start . 208) (:id . 71))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 219)\n  (:start . 214) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s746.8) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006937@unknown@formal@none@1@S@These results show that IL-4 NAF is IL-4 Stat, which is activated by JAK3 in response to IL-4 receptor engagement.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NAF") (:form . "NAF") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 65)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "jak3") (:form . "JAK3") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 85)\n  (:start . 77) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 93) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 113)\n  (:start . 103) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s746.9) (:did . :|7635985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006938@unknown@formal@none@1@S@Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 78) (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 97) (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 118)\n  (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s747.1) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006940@unknown@formal@none@1@S@The gene contains a proximal functional promoter region (-620 to +34), as well as a powerful enhancer located 3 kb upstream, both of which are involved in the response of the gene to TCR activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CD") (:stem . "-620") (:form . "-620") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "+34") (:form . "+34") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 92)\n  (:start . 84) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 101)\n  (:start . 93) (:id . 61))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 123)\n  (:start . 115) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 66))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 129) (:start . 125)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 138)\n  (:start . 133) (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 142) (:start . 139)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 151)\n  (:start . 143) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 167)\n  (:start . 159) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 179) (:start . 175)\n  (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 186) (:start . 183)\n  (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 197)\n  (:start . 187) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s747.3) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006941@unknown@formal@none@1@S@The proximal promoter contains a region termed CLEO (-54 to -31) that consists of a purine-rich element abutting an activator protein-1 (AP-1)-like site, as well as an upstream nuclear factor-kappa B (NF-kappa B) site (-85 to -76) and a CK-1 element (-101 to -92).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 46) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . 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"(") (:form . "(") (:end . 251) (:start . 250)\n  (:id . 91))\n ((:tag . "CD") (:stem . "-101") (:form . "-101") (:end . 255) (:start . 251)\n  (:id . 92))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 258) (:start . 256)\n  (:id . 93))\n ((:tag . "CD") (:stem . "-92") (:form . "-92") (:end . 262) (:start . 259)\n  (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 263) (:start . 262)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s747.4) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006942@unknown@formal@none@1@S@We show in this work that mutations in either the purine-rich region of the CLEO element or the NF-kappa B site result in reduced PMA/Ca2+ activation of a 620-bp human GM-CSF promoter-luciferase reporter construct in Jurkat T cells by 65% and 50%, respectively.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CLEO") (:form . "CLEO") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 118)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "pma/ca2+") (:form . "PMA/Ca2+") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "620-bp") (:form . "620-bp") (:end . 161)\n  (:start . 155) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 167)\n  (:start . 162) (:id . 71))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 174)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "promoter-luciferase")\n  (:form . "promoter-luciferase") (:end . 194) (:start . 175) (:id . 73))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 203)\n  (:start . 195) (:id . 74))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 213)\n  (:start . 204) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 223)\n  (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 225) (:start . 224)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 231)\n  (:start . 226) (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 237) (:start . 235)\n  (:id . 81))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 238) (:start . 237)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 83))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 245) (:start . 243)\n  (:id . 84))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 246) (:start . 245)\n  (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 86))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 260)\n  (:start . 248) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s747.5) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006943@unknown@formal@none@1@S@The major inducible protein complex that binds to the human CLEO (hCLEO) element is an AP-1-like complex that is inducible by PMA alone, but shows increased binding in response to PMA together with Ca2+ ionophore.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cleo") (:form . "CLEO") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hcleo") (:form . "hCLEO") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ap-1-like") (:form . "AP-1-like") (:end . 96)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 122)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 146)\n  (:start . 141) (:id . 69))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 156)\n  (:start . 147) (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 164)\n  (:start . 157) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 176)\n  (:start . 168) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 183) (:start . 180)\n  (:id . 75))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 192)\n  (:start . 184) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 197) (:start . 193)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 202) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 212)\n  (:start . 203) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s747.6) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006944@unknown@formal@none@1@S@Although the binding of this complex is not cyclosporin-sensitive, promoter induction is inhibited by cyclosporin treatment.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cyclosporin-sensitive")\n  (:form . "cyclosporin-sensitive") (:end . 65) (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 113)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x747.7.1) (:span 40 43)))\n (:nscopes ((:id . :x747.7.1) (:span 40 65)))\n (:identifiers (:sid . :s747.7) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006945@unknown@formal@none@1@S@A second weak inducible complex resembling nuclear factor of activated T cells (NF-AT) was also observed binding to the hCLEO region.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hcleo") (:form . "hCLEO") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s747.8) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006946@unknown@formal@none@1@S@By using recombinant proteins, we confirmed that AP-1, NF-ATp, and a higher order NF-ATp/AP-1 complex could all form with the hCLEO element, and we have also defined the sequence requirements for binding of each of these complexes.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 75) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nf-atp/ap-1") (:form . "NF-ATp/AP-1") (:end . 93)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hcleo") (:form . "hCLEO") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 152) (:start . 148)\n  (:id . 70))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 157) (:start . 153)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 165)\n  (:start . 158) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 178)\n  (:start . 170) (:id . 74))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 191)\n  (:start . 179) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 203)\n  (:start . 196) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 211) (:start . 207)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 80))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 220)\n  (:start . 215) (:id . 81))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 230)\n  (:start . 221) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s747.9) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006947@unknown@formal@none@1@S@We found that expression of a constitutively active form of calcineurin could substitute for Ca2+ ionophore and synergize with PMA to activate the GM-CSF promoter, and conversely that mutant-activated Ras could substitute for PMA and cooperate with Ca2+ ionophore.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "VB") (:stem . "synergize") (:form . "synergize") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "RB") (:stem . "conversely") (:form . "conversely") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "mutant-activated") (:form . "mutant-activated")\n  (:end . 200) (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "ras") (:form . "Ras") (:end . 204) (:start . 201)\n  (:id . 72))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 221)\n  (:start . 211) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 225) (:start . 222)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 229) (:start . 226)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 233) (:start . 230)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 243)\n  (:start . 234) (:id . 78))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 248) (:start . 244)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 253) (:start . 249)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 263)\n  (:start . 254) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s747.10) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006948@unknown@formal@none@1@S@Co-expression of Ras and calcineurin, however, did not activate the GM-CSF promoter, but required the additional expression of NF-kappa B p65.@(((:tag . "NNP") (:stem . "Co-expression") (:form . "Co-expression")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x747.11.1) (:span 51 54)))\n (:nscopes ((:id . :x747.11.1) (:span 51 83)))\n (:identifiers (:sid . :s747.11) (:did . :|7636192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006950@unknown@formal@none@1@S@An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "irf-1-dependent") (:form . "IRF-1-dependent")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "damage-induced") (:form . "damage-induced")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 79) (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s748.1) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006951@unknown@formal@none@1@S@Lymphocytes are particularly susceptible to DNA damage-induced apoptosis, a response which may serve as a form of 'altruistic suicide' to counter their intrinsic high potential for mutation and clonal expansion.@(((:tag . "NNS") (:stem . "lymphocyte") (:form . "Lymphocytes") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "susceptible") (:form . "susceptible") (:end . 40)\n  (:start . 29) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "damage-induced") (:form . "damage-induced")\n  (:end . 62) (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 72)\n  (:start . 63) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "'altruistic") (:form . "'altruistic") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "suicide") (:form . "suicide") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "VB") (:stem . "counter") (:form . "counter") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 176)\n  (:start . 167) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 189)\n  (:start . 181) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 200)\n  (:start . 194) (:id . 72))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 210)\n  (:start . 201) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x748.2.1) (:span 91 94)))\n (:hscopes ((:id . :x748.2.1) (:span 91 134)))\n (:identifiers (:sid . :s748.2) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006952@unknown@formal@none@1@S@The tumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes, but an as yet unknown, p53-independent pathway(s) appears to mediate the same event in mitogen-activated mature T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "p53-independent") (:form . "p53-independent")\n  (:end . 129) (:start . 114) (:id . 64))\n ((:tag . "NN") (:stem . "pathway(s)") (:form . "pathway(s)") (:end . 140)\n  (:start . 130) (:id . 65))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 159)\n  (:start . 152) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 195) (:start . 178) (:id . 73))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 202)\n  (:start . 196) (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 216)\n  (:start . 205) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x748.3.1) (:span 141 148)))\n (:hscopes ((:id . :x748.3.1) (:span 95 216)))\n (:identifiers (:sid . :s748.3) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006953@unknown@formal@none@1@S@Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the antioncogenic transcription factor interferon regulatory factor (IRF)-1.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "damage-induced") (:form . "damage-induced")\n  (:end . 31) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "antioncogenic") (:form . "antioncogenic")\n  (:end . 98) (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "IRF)-1") (:form . "IRF)-1") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s748.4) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006954@unknown@formal@none@1@S@Thus two different anti-onco-genic transcription factors, p53 and IRF-1, are required for distinct apoptotic pathways in T lymphocytes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "anti-onco-genic") (:form . "anti-onco-genic")\n  (:end . 34) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 56)\n  (:start . 49) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s748.5) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006955@unknown@formal@none@1@S@We also show that mitogen induction of the interleukin-1 beta converting enzyme (ICE) gene, a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, is IRF-1-dependent.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "convert") (:form . "converting") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ICE") (:form . "ICE") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 103)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 113)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Caenorhabditis") (:form . "Caenorhabditis")\n  (:end . 135) (:start . 121) (:id . 64))\n ((:tag . "NNS") (:stem . "elegan") (:form . "elegans") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ced-3") (:form . "ced-3") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "irf-1-dependent") (:form . "IRF-1-dependent")\n  (:end . 185) (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s748.6) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006956@unknown@formal@none@1@S@Ectopic overexpression of IRF-1 results in the activation of the endogenous gene for ICE and enhances the sensitivity of cells to radiation-induced apoptosis.@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 22) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ICE") (:form . "ICE") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "radiation-induced") (:form . "radiation-induced")\n  (:end . 147) (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 157)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s748.7) (:did . :|7637809|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006957@unknown@formal@none@1@S@Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation [published erratum appears in Biochim Biophys Acta 1995 Dec 27;1264(3):409]@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hydroxyurea") (:form . "hydroxyurea") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 103) (:start . 88) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Biochim") (:form . "Biochim") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "NNP") (:stem . "Biophys") (:form . "Biophys") (:end . 149)\n  (:start . 142) (:id . 62))\n ((:tag . "NNP") (:stem . "Acta") (:form . "Acta") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1995") (:form . "1995") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Dec") (:form . "Dec") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "CD") (:stem . "27;1264(3):409") (:form . "27;1264(3):409")\n  (:end . 178) (:start . 164) (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s749.1) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006958@unknown@formal@none@1@S@Hydroxyurea (HU) is an antitumor agent which also induces hemoglobinization during erythroid differentiation.@(((:tag . "NNP") (:stem . "Hydroxyurea") (:form . "Hydroxyurea") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HU") (:form . "HU") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antitumor") (:form . "antitumor") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "hemoglobinization") (:form . "hemoglobinization")\n  (:end . 75) (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 108) (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s749.2) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006960@unknown@formal@none@1@S@To further understand its mechanism of action, we investigated the effects of HU on regulation of c-jun expression prior to the onset of erythroid differentiation of K562 cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HU") (:form . "HU") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 146)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 162) (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s749.4) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006961@unknown@formal@none@1@S@HU induced a dose-dependent stimulation of c-jun synthesis.@(((:tag . "NN") (:stem . "hu") (:form . "HU") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s749.5) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006962@unknown@formal@none@1@S@The levels of c-jun mRNA was elevated 4 to 7.5-fold by HU within 2 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "RB") (:stem . "7.5-fold") (:form . "7.5-fold") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HU") (:form . "HU") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s749.6) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006963@unknown@formal@none@1@S@This was followed by a gradual decline to the basal level by 24 h.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "gradual") (:form . "gradual") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s749.7) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006964@unknown@formal@none@1@S@Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the c-jun mRNA.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pulse") (:form . "pulse") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hu") (:form . "HU") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "stabilize") (:form . "stabilizing") (:end . 172)\n  (:start . 161) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x749.8.1) (:span 65 78)))\n (:hscopes ((:id . :x749.8.1) (:span 65 187)))\n (:identifiers (:sid . :s749.8) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006965@unknown@formal@none@1@S@In addition, the level of jun protein was elevated by 2 to 5-fold within 4 h in HU treated cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "5-fold") (:form . "5-fold") (:end . 65)\n  (:start . 59) (:id . 55))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 72)\n  (:start . 66) (:id . 56))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 76) (:start . 75)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HU") (:form . "HU") (:end . 82) (:start . 80)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 90)\n  (:start . 83) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s749.9) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006966@unknown@formal@none@1@S@Furthermore, concentrations of HU below 250 microM slightly increased the 5X AP-1/CAT activity.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HU") (:form . "HU") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "CD") (:stem . "250") (:form . "250") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "5x") (:form . "5X") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AP-1/CAT") (:form . "AP-1/CAT") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s749.10) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006967@unknown@formal@none@1@S@These results strongly suggest that HU induces both transcriptional and post-transcription regulation of c-jun during erythroid differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hu") (:form . "HU") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 67) (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "post-transcription") (:form . "post-transcription")\n  (:end . 90) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 110)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 117)\n  (:start . 111) (:id . 56))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 127)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 143) (:start . 128) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x749.11.1) (:span 23 30)))\n (:hscopes ((:id . :x749.11.1) (:span 23 143)))\n (:identifiers (:sid . :s749.11) (:did . :|7640302|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006968@unknown@formal@none@1@S@Characterization of 5' end of human thromboxane receptor gene.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s750.1) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006970@unknown@formal@none@1@S@Platelet thromboxane receptors are acutely and reversibly upregulated after acute myocardial infarction.@(((:tag . "NNP") (:stem . "Platelet") (:form . "Platelet") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "RB") (:stem . "acutely") (:form . "acutely") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "RB") (:stem . "reversibly") (:form . "reversibly") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 69)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 75) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "myocardial") (:form . "myocardial") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "infarction") (:form . "infarction") (:end . 103)\n  (:start . 93) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s750.3) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006971@unknown@formal@none@1@S@To determine if platelet thromboxane receptors are under transcriptional control, we isolated and characterized human genomic DNA clones containing the 5' flanking region of the thromboxane receptor gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 72) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 111) (:start . 98) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 136)\n  (:start . 130) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 189)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 198)\n  (:start . 190) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 203) (:start . 199)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x750.4.1) (:span 13 15)))\n (:hscopes ((:id . :x750.4.1) (:span 13 80)))\n (:identifiers (:sid . :s750.4) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006972@unknown@formal@none@1@S@The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exon-intron") (:form . "exon-intron") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "RB") (:stem . "initially") (:form . "initially") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 192)\n  (:start . 187) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 198)\n  (:start . 193) (:id . 75))\n ((:tag . "JJ") (:stem . "uterine") (:form . "uterine") (:end . 206)\n  (:start . 199) (:id . 76))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 218)\n  (:start . 207) (:id . 77))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 227)\n  (:start . 219) (:id . 78))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 237) (:start . 233)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "extend") (:form . "extended") (:end . 246)\n  (:start . 238) (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 82))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 255) (:start . 251)\n  (:id . 83))\n ((:tag . "CD") (:stem . "141") (:form . "141") (:end . 259) (:start . 256)\n  (:id . 84))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 262) (:start . 260)\n  (:id . 85))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 270)\n  (:start . 263) (:id . 86))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 279)\n  (:start . 271) (:id . 87))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 284) (:start . 280)\n  (:id . 88))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 288) (:start . 285)\n  (:id . 89))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 299)\n  (:start . 289) (:id . 90))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 310)\n  (:start . 300) (:id . 91))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 316)\n  (:start . 311) (:id . 92))\n ((:tag . "JJ") (:stem . "placental") (:form . "placental") (:end . 326)\n  (:start . 317) (:id . 93))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 331) (:start . 327)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 332) (:start . 331)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s750.5) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006973@unknown@formal@none@1@S@A major transcription initiation site was located in three human tissues approximately 560 bp upstream from the translation initiation codon and 380 bp upstream from any previously identified transcription initiation site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 86) (:start . 73) (:id . 53))\n ((:tag . "CD") (:stem . "560") (:form . "560") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 123)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "CD") (:stem . "380") (:form . "380") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 205) (:start . 192) (:id . 70))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 216)\n  (:start . 206) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 221) (:start . 217)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s750.6) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006974@unknown@formal@none@1@S@The thromboxane receptor gene has neither a TATA nor a CAAT consensus site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CAAT") (:form . "CAAT") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x750.7.1) (:span 34 41 49 52)))\n (:nscopes ((:id . :x750.7.1) (:span 34 74)))\n (:identifiers (:sid . :s750.7) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006975@unknown@formal@none@1@S@Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/chloramphenicol acetyltransferase (CAT) chimera plasmids into platelet-like K562 cells.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 106)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "thromboxane") (:form . "thromboxane") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter/chloramphenicol")\n  (:form . "promoter/chloramphenicol") (:end . 160) (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 178) (:start . 161) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 183) (:start . 180)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 67))\n ((:tag . "NN") (:stem . "chimera") (:form . "chimera") (:end . 192)\n  (:start . 185) (:id . 68))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 201)\n  (:start . 193) (:id . 69))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 206) (:start . 202)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "platelet-like") (:form . "platelet-like")\n  (:end . 220) (:start . 207) (:id . 71))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 225) (:start . 221)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 231)\n  (:start . 226) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s750.8) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006976@unknown@formal@none@1@S@Thromboxane receptor promoter activity, as assessed by CAT expression, was relatively weak but was significantly enhanced by phorbol ester treatment.@(((:tag . "NNP") (:stem . "Thromboxane") (:form . "Thromboxane") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s750.9) (:did . :|7641319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006977@unknown@formal@none@1@S@Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester-responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 (AP-2) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "construct") (:form . 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5006978@unknown@formal@none@1@S@These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2-like nuclear factor binding to upstream promoter elements.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "determine") (:form . 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5006980@unknown@formal@none@1@S@IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 113) (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s751.1) (:did . :|7641692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006981@unknown@formal@none@1@S@Activation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 149) (:start . 136) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 179) (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s751.2) (:did . :|7641692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006982@unknown@formal@none@1@S@In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates (ROIs) which are required for CD28-mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 84) (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 127) (:start . 114) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROIs") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cd28-mediated") (:form . "CD28-mediated")\n  (:end . 171) (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . "JJ") (:stem . "b/cd28-responsive") (:form . "B/CD28-responsive")\n  (:end . 216) (:start . 199) (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 224)\n  (:start . 217) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 233) (:start . 229)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 244)\n  (:start . 234) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s751.3) (:did . :|7641692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006983@unknown@formal@none@1@S@Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity, followed by the activation of phospholipase A2 and 5-lipoxygenase.@(((:tag . "NNP") (:stem . "Delineation") (:form . "Delineation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "a2") (:form . "A2") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 162) (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s751.4) (:did . :|7641692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006984@unknown@formal@none@1@S@Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lipoxygenase") (:form . "lipoxygenase") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 129)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x751.5.1) (:span 9 16)))\n (:hscopes ((:id . :x751.5.1) (:span 9 129)))\n (:identifiers (:sid . :s751.5) (:did . :|7641692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006985@unknown@formal@none@1@S@These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 100) (:start . 82) (:id . 54))\n ((:tag . "VBG") (:stem . "target") (:form . "targeting") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 133) (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x751.6.1) (:span 15 21)))\n (:hscopes ((:id . :x751.6.1) (:span 15 141)))\n (:identifiers (:sid . :s751.6) (:did . :|7641692|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006986@unknown@formal@none@1@S@Infection and replication of Tat- human immunodeficiency viruses: genetic analyses of LTR and tat mutations in primary and long-term human lymphoid cells.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "Tat-") (:stem . "tat-") (:form . "Tat-") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 56) (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s752.1) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5006987@unknown@formal@none@1@S@Tat is an essential regulatory protein for the replication of human immunodeficiency virus (HIV).@(((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 19)\n  (:start . 10) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 84) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s752.2) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006988@unknown@formal@none@1@S@Mutations in the tat gene have been shown to block HIV replication in human T cells.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s752.3) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006990@unknown@formal@none@1@S@It is possible that Tat is also needed for other functions during HIV replication.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 38) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x752.5.1) (:span 6 14)))\n (:hscopes ((:id . :x752.5.1) (:span 6 81)))\n (:identifiers (:sid . :s752.5) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006991@unknown@formal@none@1@S@To test these hypotheses, we studied several tat mutants, including two stop codon mutants and one deletion mutant using replication-competent HIV-1 constructs carrying wild-type or mutant LTRs with modifications in the NF-kappa B and/or Sp1 binding sites.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "hypothesis") (:form . "hypotheses") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 120) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "replication-competent")\n  (:form . "replication-competent") (:end . 142) (:start . 121) (:id . 63))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 159)\n  (:start . 149) (:id . 65))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 193) (:start . 189)\n  (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 198) (:start . 194)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 212) (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 228)\n  (:start . 220) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 230) (:start . 229)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 237)\n  (:start . 231) (:id . 77))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 241) (:start . 238)\n  (:id . 78))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 249)\n  (:start . 242) (:id . 79))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 255)\n  (:start . 250) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s752.6) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006992@unknown@formal@none@1@S@In this study, we show that Tat- HIV-1 with wild-type LTRs can replicate in HeLa cells, and the virus produced from HeLa cells can infect primary peripheral blood lymphocytes and macrophages.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "Tat-") (:stem . "tat-") (:form . "Tat-") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 38) (:start . 33)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 72)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 101) (:start . 96)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 110)\n  (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "VB") (:stem . "infect") (:form . "infect") (:end . 137)\n  (:start . 131) (:id . 68))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 145)\n  (:start . 138) (:id . 69))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 156)\n  (:start . 146) (:id . 70))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 162)\n  (:start . 157) (:id . 71))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 174)\n  (:start . 163) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 190)\n  (:start . 179) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s752.7) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006993@unknown@formal@none@1@S@It was found that the propagation of the Tat mutants containing wild-type LTRs was less efficient than that of the LTR-modified Tat mutants.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "propagation") (:form . "propagation") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ltr-modified") (:form . "LTR-modified") (:end . 127)\n  (:start . 115) (:id . 62))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s752.8) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006994@unknown@formal@none@1@S@Large amounts of viral RNA and particles were synthesized in infections established using the tat mutants that contain modified LTRs.@(((:tag . "JJ") (:stem . "large") (:form . "Large") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "particle") (:form . "particles") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s752.9) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006995@unknown@formal@none@1@S@However, this efficient propagation of the LTR-modified tat mutants was restricted to some lymphoid cell lines that have been transformed with other viruses.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "propagation") (:form . "propagation") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ltr-modified") (:form . "LTR-modified") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 137)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s752.10) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006996@unknown@formal@none@1@S@Thus, despite its essential role for releasing an elongation block, Tat is not otherwise absolutely required for synthesis of full-length HIV transcripts and assembly of virus particles.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "release") (:form . "releasing") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "RB") (:stem . "otherwise") (:form . "otherwise") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "RB") (:stem . "absolutely") (:form . "absolutely") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 153)\n  (:start . 142) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 166)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . "NNS") (:stem . "particle") (:form . "particles") (:end . 185)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x752.11.1) (:span 75 78)))\n (:nscopes ((:id . :x752.11.1) (:span 68 185)))\n (:identifiers (:sid . :s752.11) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006997@unknown@formal@none@1@S@Direct sequencing of the viral genomes and reinfection kinetics showed no evidence of wild-type reversion even after prolonged infection with the Tat- virus.@(((:tag . "JJ") (:stem . "direct") (:form . "Direct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reinfection") (:form . "reinfection") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 70) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "reversion") (:form . "reversion") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tat-") (:form . "Tat-") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 156)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x752.12.1) (:span 71 85)))\n (:hscopes ((:id . :x752.12.1) (:span 71 156)))\n (:identifiers (:sid . :s752.12) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5006998@unknown@formal@none@1@S@The implications for in vivo HIV-1 replication and potential application of this system to the study of alternative Tat function are discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "application") (:form . "application") (:end . 72)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s752.13) (:did . :|7645208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007000@unknown@formal@none@1@S@The putative factors that couple the signal transduction from surface receptors to the activation of cytokine synthesis in natural killer (NK) cells have not been elucidated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "couple") (:form . "couple") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 56)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 137)\n  (:start . 131) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 173)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x753.2.2) (:span 154 157 163 173))\n  ((:id . :x753.2.1) (:span 4 12)))\n (:hscopes ((:id . :x753.2.1) (:span 4 148))\n  ((:id . :x753.2.2) (:span 0 173)))\n (:identifiers (:sid . :s753.2) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007001@unknown@formal@none@1@S@We report here that the nuclear factor of activated T cells (NFATp), a cyclosporin A (CsA)-sensitive factor that regulates the transcription of several cytokines, mediates CD16-induced activation of cytokine genes in human NK cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 82)\n  (:start . 71) (:id . 58))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "CsA)-sensitive") (:form . "CsA)-sensitive")\n  (:end . 100) (:start . 86) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 122)\n  (:start . 113) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 161)\n  (:start . 152) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 171)\n  (:start . 163) (:id . 71))\n ((:tag . "JJ") (:stem . "cd16-induced") (:form . "CD16-induced") (:end . 184)\n  (:start . 172) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 195)\n  (:start . 185) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 207)\n  (:start . 199) (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 222)\n  (:start . 217) (:id . 78))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 225) (:start . 223)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 231)\n  (:start . 226) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s753.3) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007002@unknown@formal@none@1@S@CD16 (Fc gamma RIIIA)-induced expression of cytokine mRNA in NK cells occurs via a CsA-sensitive and Ca(2+)-dependent mechanism.@(((:tag . "NNP") (:stem . "CD16") (:form . "CD16") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "RIIIA)-induced") (:form . "RIIIA)-induced")\n  (:end . 29) (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 96) (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 117) (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s753.4) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007003@unknown@formal@none@1@S@Stimulation of NK cells with CD16 ligands induces NFAT-like DNA binding activity in the nuclear extracts from these cells, as detected in electrophoretic mobility shift assays.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd16") (:form . "CD16") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "nfat-like") (:form . "NFAT-like") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 153) (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 168)\n  (:start . 163) (:id . 67))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 175)\n  (:start . 169) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s753.5) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007004@unknown@formal@none@1@S@This occurs with fast kinetics after stimulation, via a CsA-sensitive and Ca(2+)-dependent mechanism that does not require de novo protein synthesis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fast") (:form . "fast") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 90) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x753.6.1) (:span 111 114)))\n (:nscopes ((:id . :x753.6.1) (:span 111 148)))\n (:identifiers (:sid . :s753.6) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007005@unknown@formal@none@1@S@NK cell NFAT is present in the cytosol of nonstimulated cells, migrates to the nucleus upon stimulation, and can associate with AP-1.@(((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nonstimulated") (:form . "nonstimulated")\n  (:end . 55) (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "migrate") (:form . "migrates") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 103)\n  (:start . 92) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 122)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s753.7) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007006@unknown@formal@none@1@S@Two distinct molecules, NFATp and NFATc, have been reported to mediate NFAT activity.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s753.8) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007007@unknown@formal@none@1@S@The results of supershift assays using NFATp- and NFATc- specific antibodies indicate that NK cell activation early after CD16 ligand binding involves primarily, if not exclusively, NFATp, and Western blot analysis shows that this has the same electrophoretic mobility (approximately 120 kD) as that of T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nfatp-") (:form . 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5007008@unknown@formal@none@1@S@NK cells do not express NFATc constitutively, but NFATc mRNA accumulation is induced in these cells within 2 h of stimulation with CD16 ligands.@(((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 73)\n  (:start . 61) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 125)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd16") (:form . "CD16") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x753.10.1) (:span 12 15)))\n (:nscopes ((:id . :x753.10.1) (:span 12 44)))\n (:identifiers (:sid . :s753.10) (:did . :|7650486|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007010@unknown@formal@none@1@S@These results provide the first direct evidence that both CsA-sensitive transcription factors, NFATp and NFATc, are expressed in human NK cells, and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells, results in early activation of NFATp and subsequently induced expression of NFATc mRNA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . 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5007011@unknown@formal@none@1@S@Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "NNP") (:stem . "Jak") (:form . "Jak") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "virus-transformed") (:form . "virus-transformed")\n  (:end . 137) (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s754.1) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007012@unknown@formal@none@1@S@HTLV-1 infection causes an adult T cell leukemia in humans.@(((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s754.2) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007013@unknown@formal@none@1@S@The viral encoded protein tax, is thought to play an important role in oncogenesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 62)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 82)\n  (:start . 71) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x754.3.1) (:span 34 41)))\n (:hscopes ((:id . :x754.3.1) (:span 0 82)))\n (:identifiers (:sid . :s754.3) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007014@unknown@formal@none@1@S@Our previous data obtained from a tax transgenic mouse model revealed that tax transforms mouse fibroblasts but not thymocytes, despite comparable levels of tax expression in both tissues.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "transform") (:form . "transforms") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 153)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 179) (:start . 175)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 187)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x754.4.1) (:span 112 115)))\n (:nscopes ((:id . :x754.4.1) (:span 112 126)))\n (:identifiers (:sid . :s754.4) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007015@unknown@formal@none@1@S@Constitutive tyrosine phosphorylation of a 130-kD protein(s) was observed in the tax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines, but not in thymocytes from Thy-tax transgenic mice.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 37) (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "130-kd") (:form . "130-kD") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "protein(s)") (:form . "protein(s)") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transformed") (:form . "transformed") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 107)\n  (:start . 97) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 128)\n  (:start . 122) (:id . 60))\n ((:tag . "VBD") (:stem . "transform") (:form . "transformed") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 155)\n  (:start . 147) (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 184)\n  (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "thy-tax") (:form . "Thy-tax") (:end . 197)\n  (:start . 190) (:id . 71))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 208)\n  (:start . 198) (:id . 72))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 213)\n  (:start . 209) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x754.5.1) (:span 167 170)))\n (:nscopes ((:id . :x754.5.1) (:span 167 213)))\n (:identifiers (:sid . :s754.5) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007016@unknown@formal@none@1@S@Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies, identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines.@(((:tag . "NNP") (:stem . "Phosphotyrosine") (:form . "Phosphotyrosine")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 35) (:start . 16) (:id . 43))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 44)\n  (:start . 36) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 55)\n  (:start . 48) (:id . 46))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 60) (:start . 56)\n  (:id . 47))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 69)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Jak") (:form . "Jak") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "p130") (:form . "p130") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "jak2") (:form . "Jak2") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 162)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "JJ") (:stem . "fibroblastic") (:form . "fibroblastic") (:end . 181)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 186) (:start . 182)\n  (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 70))\n ((:tag . "NN") (:stem . "jak3") (:form . "Jak3") (:end . 200) (:start . 196)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 210)\n  (:start . 204) (:id . 73))\n ((:tag . "VBD") (:stem . "transform") (:form . "transformed") (:end . 222)\n  (:start . 211) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 228)\n  (:start . 223) (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 230) (:start . 229)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 235) (:start . 231)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 241)\n  (:start . 236) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s754.6) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007017@unknown@formal@none@1@S@Phosphorylation of Jak2 in tax transformed cells resulted from high expression of IL-6.@(((:tag . "NN") (:stem . "phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "jak2") (:form . "Jak2") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s754.7) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007018@unknown@formal@none@1@S@Tyrosine phosphorylation of this protein could also be induced in Balb/c3T3 cells using a supernatant from the B line, which was associated with induction of cell proliferation.@(((:tag . "NNP") (:stem . "Tyrosine") (:form . "Tyrosine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 24) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "balb/c3t3") (:form . "Balb/c3T3") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "supernatant") (:form . "supernatant") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 154)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 176) (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s754.8) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007020@unknown@formal@none@1@S@Constitutive phosphorylation of Jak kinases may facilitate tumor growth in both HTLV-1 infected human T cells and the transgenic mouse model.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 28) (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jak") (:form . "Jak") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x754.10.1) (:span 44 47)))\n (:hscopes ((:id . :x754.10.1) (:span 44 140)))\n (:identifiers (:sid . :s754.10) (:did . :|7657825|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007021@unknown@formal@none@1@S@Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 55) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s755.1) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007022@unknown@formal@none@1@S@Erythropoietin (Epo), the primary regulator of the production of erythroid cells, acts by binding to a cell surface receptor (EpoR) on erythroid progenitors.@(((:tag . "NN") (:stem . "erythropoietin") (:form . "Erythropoietin")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Epo") (:form . "Epo") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EpoR") (:form . "EpoR") (:end . 130) (:start . 126)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 134) (:start . 132)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 144)\n  (:start . 135) (:id . 69))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 156)\n  (:start . 145) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s755.2) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007023@unknown@formal@none@1@S@We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5' flanking region of the human EpoR gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 151)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "epor") (:form . "EpoR") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s755.3) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007024@unknown@formal@none@1@S@In erythroid cells most of the transcription activity was contained in a 150 bp promoter fragment with binding sites for transcription factors AP2, Sp1 and the erythroid-specific GATA-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 134) (:start . 121) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "ap2") (:form . "AP2") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 178) (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 185)\n  (:start . 179) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s755.4) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007025@unknown@formal@none@1@S@The 150 bp hEpoR promoter exhibited high and low activity in erythroid OCIM1 and K562 cells, respectively, reflecting the high and low levels of constitutive hEpoR expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "hEpoR") (:form . "hEpoR") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "ocim1") (:form . "OCIM1") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 157)\n  (:start . 145) (:id . 68))\n ((:tag . "NNP") (:stem . "hEpoR") (:form . "hEpoR") (:end . 163)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 174)\n  (:start . 164) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s755.5) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007026@unknown@formal@none@1@S@The GATA-1 and Sp1 binding sites in this promoter lacking a TATA sequence were necessary for a high level of transcription activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x755.6.1) (:span 50 57)))\n (:nscopes ((:id . :x755.6.1) (:span 50 73)))\n (:identifiers (:sid . :s755.6) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007027@unknown@formal@none@1@S@Protein-DNA binding studies suggested that Sp1 and two other CCGCCC binding proteins from erythroid and non-erythroid cells could bind to the Sp1 binding motif.@(((:tag . "JJ") (:stem . "protein-dna") (:form . "Protein-DNA") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CCGCCC") (:form . "CCGCCC") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "non-erythroid") (:form . "non-erythroid")\n  (:end . 117) (:start . 104) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 153)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x755.7.1) (:span 124 129))\n  ((:id . :x755.7.2) (:span 28 37)))\n (:hscopes ((:id . :x755.7.1) (:span 124 159))\n  ((:id . :x755.7.2) (:span 28 159)))\n (:identifiers (:sid . :s755.7) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007028@unknown@formal@none@1@S@By increasing GATA-1 levels via co-transfection, we were able to transactivate the hEpoR promoter in K562 cells and non-erythroid cells, but not in the highly active OCIM1 cells, although GATA-1 mRNA levels were comparable in OCIM1 and K562.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "co-transfection") (:form . "co-transfection")\n  (:end . 47) (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "hEpoR") (:form . "hEpoR") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "non-erythroid") (:form . "non-erythroid")\n  (:end . 129) (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 165)\n  (:start . 159) (:id . 69))\n ((:tag . "NN") (:stem . "ocim1") (:form . "OCIM1") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 187)\n  (:start . 179) (:id . 73))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 194)\n  (:start . 188) (:id . 74))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 199) (:start . 195)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 206)\n  (:start . 200) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 211) (:start . 207)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 222)\n  (:start . 212) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 225) (:start . 223)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "OCIM1") (:form . "OCIM1") (:end . 231)\n  (:start . 226) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 81))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 240) (:start . 236)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x755.8.1) (:span 141 144)))\n (:nscopes ((:id . :x755.8.1) (:span 141 177)))\n (:identifiers (:sid . :s755.8) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007030@unknown@formal@none@1@S@These data suggest that while GATA-1 can transactivate the EpoR promoter, the level of hEpoR gene expression does not depend on GATA-1 alone.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "epor") (:form . "EpoR") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "hEpoR") (:form . "hEpoR") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x755.10.2) (:span 11 18)))\n (:ncues ((:id . :x755.10.1) (:span 114 117)))\n (:hscopes ((:id . :x755.10.2) (:span 11 140)))\n (:nscopes ((:id . :x755.10.1) (:span 114 140)))\n (:identifiers (:sid . :s755.10) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007031@unknown@formal@none@1@S@Rather, hEpoR transcription activity depends on coordination between Sp1 and GATA-1 with other cell-specific factors, including possibly other Sp1-like binding proteins, to provide high level, tissue-specific expression.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "hEpoR") (:form . "hEpoR") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "coordination") (:form . "coordination") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 136)\n  (:start . 128) (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . "JJ") (:stem . "sp1-like") (:form . "Sp1-like") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 159)\n  (:start . 152) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 168)\n  (:start . 160) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 180)\n  (:start . 173) (:id . 67))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 191)\n  (:start . 186) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 208) (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 219)\n  (:start . 209) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x755.11.1) (:span 128 136)))\n (:hscopes ((:id . :x755.11.1) (:span 118 168)))\n (:identifiers (:sid . :s755.11) (:did . :|7659529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007032@unknown@formal@none@1@S@TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.@(((:tag . "NN") (:stem . "tcl1") (:form . "TCL1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "preleukemic") (:form . "preleukemic") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ataxia-telangiectasia")\n  (:form . "ataxia-telangiectasia") (:end . 84) (:start . 63) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s756.1) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007033@unknown@formal@none@1@S@The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions [inv14(q11;q32.1)] with TCR alpha/beta loci in T-cell leukemias, such as T-prolymphocytic (T-PLL).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tcl1") (:form . "TCL1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "14q32.1") (:form . "14q32.1") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 86) (:start . 72) (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "t(14;14)(q11;q32.1)")\n  (:form . "t(14;14)(q11;q32.1)") (:end . 107) (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "t(7;14)(q35;q32.1)") (:form . "t(7;14)(q35;q32.1)")\n  (:end . 130) (:start . 112) (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 131) (:start . 130)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "inversion") (:form . "inversions") (:end . 146)\n  (:start . 136) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 148) (:start . 147)\n  (:id . 61))\n ((:tag . "CD") (:stem . "inv14(q11;q32.1)") (:form . "inv14(q11;q32.1)")\n  (:end . 164) (:start . 148) (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 165) (:start . 164)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 174) (:start . 171)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha/beta") (:form . "alpha/beta") (:end . 185)\n  (:start . 175) (:id . 66))\n ((:tag . "NNS") (:stem . "locus") (:form . "loci") (:end . 190)\n  (:start . 186) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 200)\n  (:start . 194) (:id . 69))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 210)\n  (:start . 201) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 216) (:start . 212)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 219) (:start . 217)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "t-prolymphocytic") (:form . "T-prolymphocytic")\n  (:end . 236) (:start . 220) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 238) (:start . 237)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "T-PLL") (:form . "T-PLL") (:end . 243)\n  (:start . 238) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 244) (:start . 243)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s756.2) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007034@unknown@formal@none@1@S@It is also involved in T- acute and- chronic leukemias arising in cases of ataxia-telangiectasia (AT), an immunodeficiency syndrome.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-") (:form . "T-") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and-") (:form . "and-") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "VBG") (:stem . "arise") (:form . "arising") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ataxia-telangiectasia")\n  (:form . "ataxia-telangiectasia") (:end . 96) (:start . 75) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "AT") (:form . "AT") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 122) (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s756.3) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007035@unknown@formal@none@1@S@Similar chromosomal rearrangements occur also in the clonally expanded T cells in AT patients before the appearance of the overt leukemia.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 34) (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 40) (:start . 35)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 45) (:start . 41)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "RB") (:stem . "clonally") (:form . "clonally") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "VBN") (:stem . "expand") (:form . "expanded") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AT") (:form . "AT") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "overt") (:form . "overt") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s756.4) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007036@unknown@formal@none@1@S@We have analyzed the expression of TCL1 mRNA and protein in peripheral blood lymphocytes (PBLs) from four AT cases and from healthy controls.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCL1") (:form . "TCL1") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBLs") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "AT") (:form . "AT") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 131)\n  (:start . 124) (:id . 65))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 140)\n  (:start . 132) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s756.5) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007037@unknown@formal@none@1@S@We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcl1") (:form . "TCL1") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 45) (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pbl") (:form . "PBLs") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AT") (:form . "AT") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 74)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 94)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 112)\n  (:start . 102) (:id . 62))\n ((:tag . "VBG") (:stem . "exhibit") (:form . "exhibiting") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "t(14;14)") (:form . "t(14;14)") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 150) (:start . 137) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 177)\n  (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 190)\n  (:start . 185) (:id . 74))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 196)\n  (:start . 191) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x756.6.1) (:span 155 158)))\n (:nscopes ((:id . :x756.6.1) (:span 155 196)))\n (:identifiers (:sid . :s756.6) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007038@unknown@formal@none@1@S@Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14.@(((:tag . "NNP") (:stem . "Fluorescence") (:form . "Fluorescence") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tcl1") (:form . 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"chromosome") (:end . 301)\n  (:start . 291) (:id . 88))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 304) (:start . 302)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s756.7) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007040@unknown@formal@none@1@S@Deregulation of TCL1 is the first event in the initiation of malignancy in these types of leukemias and represents a potential tool for clinical evaluation.@(((:tag . "NN") (:stem . "deregulation") (:form . "Deregulation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TCL1") (:form . "TCL1") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "malignancy") (:form . "malignancy") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 155)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x756.9.1) (:span 117 126)))\n (:hscopes ((:id . :x756.9.1) (:span 117 155)))\n (:identifiers (:sid . :s756.9) (:did . :|7662982|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007041@unknown@formal@none@1@S@Interleukin-2 promoter activity in Epstein-Barr virus-transformed B lymphocytes is controlled by nuclear factor-chi B.@(((:tag . "NN") (:stem . "interleukin-2") (:form . "Interleukin-2")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 47)\n  (:start . 35) (:id . 46))\n ((:tag . "JJ") (:stem . "virus-transformed") (:form . "virus-transformed")\n  (:end . 65) (:start . 48) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 79)\n  (:start . 68) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 93)\n  (:start . 83) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 104)\n  (:start . 97) (:id . 53))\n ((:tag . "NN") (:stem . "factor-chi") (:form . "factor-chi") (:end . 115)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s757.1) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007042@unknown@formal@none@1@S@The regulation of interleukin (IL)-2 gene expression has been investigated mainly in T lymphocytes, the predominant producers of IL-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "IL)-2") (:form . "IL)-2") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 98)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "producer") (:form . "producers") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s757.2) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007043@unknown@formal@none@1@S@However, B cells can also synthesize IL-2.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VB") (:stem . "synthesize") (:form . "synthesize") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s757.3) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007044@unknown@formal@none@1@S@In the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EBV)-transformed") (:form . "EBV)-transformed")\n  (:end . 110) (:start . 94) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "secrete") (:form . "secreting") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 181)\n  (:start . 176) (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 193)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 198) (:start . 194)\n  (:id . 74))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 206)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 219)\n  (:start . 207) (:id . 76))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 230)\n  (:start . 220) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 234) (:start . 231)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 243) (:start . 239)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 253)\n  (:start . 244) (:id . 81))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 263)\n  (:start . 254) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s757.4) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007045@unknown@formal@none@1@S@Transient transfections using reporter constructs with multiples of transcription factor binding sites from the IL-2 promoter [distal nuclear factor (NF)-AT, proximal NF-AT, AP-1/Octamer (UPS) or NF-chi B (TCEd) sites] were performed.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transfection") (:form . "transfections")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 29) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 49)\n  (:start . 39) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "multiple") (:form . "multiples") (:end . 64)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 102) (:start . 97)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 116) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 133)\n  (:start . 127) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 141)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF)-AT") (:form . "NF)-AT") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "AP-1/Octamer") (:form . "AP-1/Octamer")\n  (:end . 186) (:start . 174) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "UPS") (:form . "UPS") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 202)\n  (:start . 196) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 204) (:start . 203)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 210) (:start . 206)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 211) (:start . 210)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 217)\n  (:start . 212) (:id . 78))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 218) (:start . 217)\n  (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 223) (:start . 219)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 233)\n  (:start . 224) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s757.5) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007046@unknown@formal@none@1@S@In EBV-transformed B clones, the chi B site exerted the strongest inducible activity; the NF-AT binding sites showed either no or only weak activity compared to Jurkat T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chi") (:form . "chi") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "exert") (:form . "exerted") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "JJS") (:stem . "strong") (:form . "strongest") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x757.6.2) (:span 117 123 127 129)))\n (:ncues ((:id . :x757.6.1) (:span 124 126)))\n (:hscopes ((:id . :x757.6.2) (:span 117 139)))\n (:nscopes ((:id . :x757.6.1) (:span 124 126)))\n (:identifiers (:sid . :s757.6) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007047@unknown@formal@none@1@S@An IL-2 promoter bearing a defective NF-chi B site was completely inactive in EBV-transformed B cells, while it still had activity in Jurkat T cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s757.7) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007048@unknown@formal@none@1@S@In seven EBV-B cell clones or lines differing in their capacity to secrete IL-2, the activity of the IL-2 promoter correlated well with the status of IL-2 secretion.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ebv-b") (:form . "EBV-B") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "differ") (:form . "differing") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 54)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "secrete") (:form . "secrete") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 146)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 164)\n  (:start . 155) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s757.8) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007050@unknown@formal@none@1@S@Electrophoretic mobility shift assays using protein extracts from EBV-B cells and the IL-2 NF-chi B probe revealed the constitutive generation of chi B complexes in IL-2-secreting cells consisting mainly of heterodimeric p50/p65 complexes.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ebv-b") (:form . "EBV-B") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 131)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chi") (:form . "chi") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2-secreting") (:form . "IL-2-secreting")\n  (:end . 179) (:start . 165) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 68))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 196)\n  (:start . 186) (:id . 69))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 203)\n  (:start . 197) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 220) (:start . 207) (:id . 72))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 228)\n  (:start . 221) (:id . 73))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 238)\n  (:start . 229) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s757.10) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007051@unknown@formal@none@1@S@A weaker chi B complex formation and faster-migrating complexes were detected in non-IL-2-secreting cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "weak") (:form . "weaker") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "chi") (:form . "chi") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "faster-migrating") (:form . "faster-migrating")\n  (:end . 53) (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "non-il-2-secreting") (:form . "non-IL-2-secreting")\n  (:end . 99) (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s757.11) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007052@unknown@formal@none@1@S@These results demonstrate that the IL-2 NF-chi B site is indispensable for the activity of the IL-2 promoter in EBV-transformed B cells, whereas other transcription factors appear to be less important for IL-2 expression in these cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-chi") (:form . "NF-chi") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "indispensable") (:form . "indispensable")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 127) (:start . 112) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 164) (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 179)\n  (:start . 173) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 209) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 220)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 77))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 229)\n  (:start . 224) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 235)\n  (:start . 230) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x757.12.1) (:span 173 179)))\n (:hscopes ((:id . :x757.12.1) (:span 145 235)))\n (:identifiers (:sid . :s757.12) (:did . :|7664781|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007053@unknown@formal@none@1@S@Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.@(((:tag . "JJ") (:stem . "ubiquitin-mediated") (:form . "Ubiquitin-mediated")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 29)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 59) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 69)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 79)\n  (:start . 70) (:id . 49))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 84) (:start . 80)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s758.1) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007054@unknown@formal@none@1@S@Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.@(((:tag . "NNP") (:stem . "Reconstitution") (:form . "Reconstitution")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 55) (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ubiquitin-carrier") (:form . "ubiquitin-carrier")\n  (:end . 80) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "E2") (:form . "E2") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "ubiquitin-protein") (:form . "ubiquitin-protein")\n  (:end . 123) (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "E3") (:form . "E3") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "conjugation") (:form . "conjugation") (:end . 159)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s758.2) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007055@unknown@formal@none@1@S@In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 34) (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 116)\n  (:start . 111) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 144)\n  (:start . 136) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 150)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 161) (:start . 158)\n  (:id . 72))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 168)\n  (:start . 162) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s758.3) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007056@unknown@formal@none@1@S@p50 is translated as a precursor of 105 kDa.@(((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "105") (:form . "105") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s758.4) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007057@unknown@formal@none@1@S@The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "form") (:form . "forming") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s758.5) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007058@unknown@formal@none@1@S@The mechanism of generation of p50 is not known.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x758.6.1) (:span 38 47)))\n (:hscopes ((:id . :x758.6.1) (:span 0 47)))\n (:identifiers (:sid . :s758.6) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007060@unknown@formal@none@1@S@Palombella and colleagues (Palombella, V.J., Rando, O.J., Goldberg, A.L., and Maniatis, T.(1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.@(((:tag . "NNP") (:stem . "Palombella") (:form . "Palombella") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "colleague") (:form . "colleagues") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Palombella") (:form . "Palombella") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "V.J.") (:form . "V.J.") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rando") (:form . "Rando") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "O.J.") (:form . "O.J.") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Goldberg") (:form . "Goldberg") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "A.L.") (:form . "A.L.") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Maniatis") (:form . "Maniatis") (:end . 86)\n  (:start . 78) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "T.(1994)") (:form . "T.(1994)") (:end . 96)\n  (:start . 88) (:id . 61))\n ((:tag . "NNP") (:stem . "Cell") (:form . "Cell") (:end . 101) (:start . 97)\n  (:id . 62))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 104) (:start . 102)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 64))\n ((:tag . "CD") (:stem . "773-785") (:form . "773-785") (:end . 113)\n  (:start . 106) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 119) (:start . 115)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 125)\n  (:start . 120) (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 140)\n  (:start . 131) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 152)\n  (:start . 144) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 74))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 171)\n  (:start . 161) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 176) (:start . 175)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 186)\n  (:start . 177) (:id . 78))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 193)\n  (:start . 187) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 198) (:start . 197)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 208)\n  (:start . 199) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 83))\n ((:tag . "RB") (:stem . "artificially") (:form . "artificially") (:end . 222)\n  (:start . 210) (:id . 84))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 234)\n  (:start . 223) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "60-kda") (:form . "60-kDa") (:end . 242)\n  (:start . 236) (:id . 87))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 252)\n  (:start . 243) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s758.8) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007061@unknown@formal@none@1@S@They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s758.9) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007062@unknown@formal@none@1@S@In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . 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"demonstrate") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "LS") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ubiquitin-proteasome")\n  (:form . "ubiquitin-proteasome") (:end . 137) (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 144)\n  (:start . 138) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . 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5007063@unknown@formal@none@1@S@This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E6-AP") (:form . "E6-AP") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "p53-conjugating") (:form . "p53-conjugating")\n  (:end . 61) (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "\\"N-end") (:form . "\\"N-end") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 112)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s758.11) (:did . :|7665588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007064@unknown@formal@none@1@S@The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 60) (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s759.1) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007065@unknown@formal@none@1@S@PU.1 is a hematopoietic transcription factor belonging to the Ets-family.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ets-family") (:form . "Ets-family") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s759.2) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007066@unknown@formal@none@1@S@It is identical to the Spi-1 oncogene, which is implicated in spleen focus-forming virus-induced murine erythroleukemias.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "spi-1") (:form . "Spi-1") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "spleen") (:form . "spleen") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "focus-forming") (:form . "focus-forming")\n  (:end . 82) (:start . 69) (:id . 55))\n ((:tag . "JJ") (:stem . "virus-induced") (:form . "virus-induced")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "erythroleukemia") (:form . "erythroleukemias")\n  (:end . 120) (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s759.3) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007067@unknown@formal@none@1@S@PU.1 seems to be required for early development of multiple hematopoietic lineages, but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage-differentiation lineage.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 73) (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 136) (:start . 122) (:id . 62))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B-cell-and") (:form . "B-cell-and") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "monocyte/macrophage-differentiation")\n  (:form . "monocyte/macrophage-differentiation") (:end . 208) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 216)\n  (:start . 209) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x759.4.1) (:span 5 10)))\n (:hscopes ((:id . :x759.4.1) (:span 0 82)))\n (:identifiers (:sid . :s759.4) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007068@unknown@formal@none@1@S@It binds the so-called Pu box, an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "Pu") (:form . "Pu") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 43)\n  (:start . 34) (:id . 50))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 59) (:start . 44) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s759.5) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007070@unknown@formal@none@1@S@PU.1 mRNA expression and PU.1 DNA binding activity, as measured by Northern blot analysis and electrophoretic mobility shift assay, respectively, were evident in cell lines representing pro-B, pre-B, and mature B cells.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 109) (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 144)\n  (:start . 132) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 185)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "pro-b") (:form . "pro-B") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "pre-b") (:form . "pre-B") (:end . 198)\n  (:start . 193) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 210)\n  (:start . 204) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 212) (:start . 211)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s759.7) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007071@unknown@formal@none@1@S@We could also show Pu box-dependent transactivation of a reporter gene in transient transfections in these cell lines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Pu") (:form . "Pu") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "box-dependent") (:form . "box-dependent")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 51) (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "transfection") (:form . "transfections")\n  (:end . 97) (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s759.8) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007072@unknown@formal@none@1@S@In contrast, in a number of multiple myeloma cell lines, representing differentiated, plasma cell-like B cells, PU.1 DNA binding activity, mRNA expression, and Pu box-dependent transactivation were absent or detectable at a very low level.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 69)\n  (:start . 57) (:id . 54))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 84) (:start . 70) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "JJ") (:stem . "cell-like") (:form . "cell-like") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 154)\n  (:start . 144) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Pu") (:form . "Pu") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "box-dependent") (:form . "box-dependent")\n  (:end . 176) (:start . 163) (:id . 72))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 192) (:start . 177) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 207) (:start . 205)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 218)\n  (:start . 208) (:id . 77))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 221) (:start . 219)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 223) (:start . 222)\n  (:id . 79))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 228) (:start . 224)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 232) (:start . 229)\n  (:id . 81))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 238)\n  (:start . 233) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x759.9.1) (:span 198 204)))\n (:nscopes ((:id . :x759.9.1) (:span 160 204)))\n (:identifiers (:sid . :s759.9) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007073@unknown@formal@none@1@S@In lymphoblastoid cell lines, which exemplify an intermediate stage of B-cell differentiation, a reduced expression and activity were observed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 17) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "exemplify") (:form . "exemplify") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 93) (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 142)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s759.10) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007074@unknown@formal@none@1@S@The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 112) (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "VBP") (:stem . "contradict") (:form . "contradict") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 167)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 181)\n  (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 202) (:start . 198)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 215)\n  (:start . 206) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 226)\n  (:start . 220) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 77))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 242)\n  (:start . 230) (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 247) (:start . 243)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 253)\n  (:start . 248) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s759.11) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007075@unknown@formal@none@1@S@At present, it is unclear whether the lack of PU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "myeloma") (:form . "myeloma") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "malignancy-associated")\n  (:form . "malignancy-associated") (:end . 146) (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "exemplify") (:form . "exemplifies") (:end . 183)\n  (:start . 172) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 192)\n  (:start . 186) (:id . 72))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 206) (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 217)\n  (:start . 207) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 75))\n ((:tag . "RB") (:stem . "terminally") (:form . "terminally") (:end . 231)\n  (:start . 221) (:id . 76))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 246) (:start . 232) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 248) (:start . 247)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 254)\n  (:start . 249) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x759.12.1) (:span 169 171))\n  ((:id . :x759.12.3) (:span 26 33)) ((:id . :x759.12.4) (:span 18 25)))\n (:ncues ((:id . :x759.12.2) (:span 38 42)))\n (:hscopes ((:id . :x759.12.1) (:span 112 254))\n  ((:id . :x759.12.3) (:span 26 254)) ((:id . :x759.12.4) (:span 18 254)))\n (:nscopes ((:id . :x759.12.2) (:span 38 111)))\n (:identifiers (:sid . :s759.12) (:did . :|7670114|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007076@unknown@formal@none@1@S@A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s760.1) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007077@unknown@formal@none@1@S@Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 114) (:start . 101) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s760.2) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007078@unknown@formal@none@1@S@Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.@(((:tag . "JJ") (:stem . "prior") (:form . "Prior") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s760.3) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007080@unknown@formal@none@1@S@This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 19) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ZIP") (:form . "ZIP") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 72)\n  (:start . 66) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 83)\n  (:start . 76) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 108)\n  (:start . 97) (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 118)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 130)\n  (:start . 124) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 159) (:start . 145) (:id . 69))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 169)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 183) (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 190)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 194) (:start . 191)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 212)\n  (:start . 203) (:id . 76))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 218)\n  (:start . 213) (:id . 77))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 225)\n  (:start . 219) (:id . 78))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 234)\n  (:start . 226) (:id . 79))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 242)\n  (:start . 235) (:id . 80))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 248)\n  (:start . 243) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s760.5) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007081@unknown@formal@none@1@S@In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "secrete") (:form . "secrete") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 85) (:start . 80)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 99)\n  (:start . 89) (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "secrete") (:form . "secreting") (:end . 114)\n  (:start . 105) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 134)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 148)\n  (:start . 141) (:id . 67))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 159)\n  (:start . 149) (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 172)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x760.6.1) (:span 31 34)))\n (:nscopes ((:id . :x760.6.1) (:span 31 47)))\n (:identifiers (:sid . :s760.6) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007082@unknown@formal@none@1@S@In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ZIP") (:form . "ZIP") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 38)\n  (:start . 32) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 54)\n  (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 63) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 98)\n  (:start . 87) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ZIP") (:form . "ZIP") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 114) (:start . 110)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 66))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 128)\n  (:start . 123) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 140)\n  (:start . 132) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 152)\n  (:start . 145) (:id . 71))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 157) (:start . 153)\n  (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 166)\n  (:start . 158) (:id . 73))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 175)\n  (:start . 167) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s760.7) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007083@unknown@formal@none@1@S@These results suggest a critical role of the ZIP site for IL-2 promoter activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ZIP") (:form . "ZIP") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x760.8.1) (:span 14 21)))\n (:hscopes ((:id . :x760.8.1) (:span 14 80)))\n (:identifiers (:sid . :s760.8) (:did . :|7673240|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007084@unknown@formal@none@1@S@Nitric oxide-stimulated guanine nucleotide exchange on p21ras.@(((:tag . "JJ") (:stem . "nitric") (:form . "Nitric") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "oxide-stimulated") (:form . "oxide-stimulated")\n  (:end . 23) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 42)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 51)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 61)\n  (:start . 55) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s761.1) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007085@unknown@formal@none@1@S@The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monomeric") (:form . "monomeric") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "convert") (:form . "converting") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 112) (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 151)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 158)\n  (:start . 152) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s761.2) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007086@unknown@formal@none@1@S@Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 48)\n  (:start . 39) (:id . 52))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 55)\n  (:start . 49) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 66) (:start . 65)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 85)\n  (:start . 76) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 100)\n  (:start . 92) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "gtp-bound") (:form . "GTP-bound") (:end . 113)\n  (:start . 104) (:id . 64))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 120)\n  (:start . 114) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s761.3) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007087@unknown@formal@none@1@S@In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pure") (:form . "pure") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s761.4) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007088@unknown@formal@none@1@S@Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange.@(((:tag . "JJ") (:stem . "circular") (:form . "Circular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dichroism") (:form . "dichroism") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "profound") (:form . "profound") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "conformational") (:form . "conformational")\n  (:end . 77) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 84)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GDP/GTP") (:form . "GDP/GTP") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s761.5) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007090@unknown@formal@none@1@S@Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "no-induced") (:form . "NO-induced") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 175) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s761.7) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007091@unknown@formal@none@1@S@These studies identify p21ras as a target of the same cell.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s761.8) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007092@unknown@formal@none@1@S@These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 88)\n  (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . "VBZ") (:stem . "mimic") (:form . "mimics") (:end . 121)\n  (:start . 115) (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 137)\n  (:start . 130) (:id . 67))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 148)\n  (:start . 138) (:id . 68))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 165)\n  (:start . 158) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x761.9.1) (:span 63 70)))\n (:hscopes ((:id . :x761.9.1) (:span 63 165)))\n (:identifiers (:sid . :s761.9) (:did . :|7706235|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007093@unknown@formal@none@1@S@Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "vacuolar") (:form . "vacuolar") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "H(+)-ATPase") (:form . "H(+)-ATPase") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 89) (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 95) (:start . 90)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s762.1) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007094@unknown@formal@none@1@S@Monocyte-macrophage differentiation was used as a model system for studying gene regulation of the human vacuolar H(+)-ATPase (V-ATPase).@(((:tag . "JJ") (:stem . "monocyte-macrophage")\n  (:form . "Monocyte-macrophage") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 35) (:start . 20) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 44) (:start . 40)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "vacuolar") (:form . "vacuolar") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "H(+)-ATPase") (:form . "H(+)-ATPase") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "v-atpase") (:form . "V-ATPase") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s762.2) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007095@unknown@formal@none@1@S@We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "v-atpase") (:form . "V-ATPase") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 156) (:start . 141) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 181) (:start . 161) (:id . 67))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 192)\n  (:start . 182) (:id . 68))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 198)\n  (:start . 193) (:id . 69))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 206)\n  (:start . 199) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 210) (:start . 207)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 220)\n  (:start . 211) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 228) (:start . 224)\n  (:id . 74))\n ((:tag . "NN") (:stem . "v-atpase") (:form . "V-ATPase") (:end . 237)\n  (:start . 229) (:id . 75))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 245)\n  (:start . 238) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s762.3) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007096@unknown@formal@none@1@S@From nuclear runoff experiments, we found that one subunit in particular, the B2 isoform (Mr = 56,000), was amplified primarily by transcriptional means.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "runoff") (:form . "runoff") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Mr") (:form . "Mr") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "CD") (:stem . "56,000") (:form . "56,000") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 117)\n  (:start . 108) (:id . 65))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 127)\n  (:start . 118) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 146) (:start . 131) (:id . 68))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s762.4) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007097@unknown@formal@none@1@S@We have begun to examine the structure of the B2 subunit promoter region.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "begin") (:form . "begun") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s762.5) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007098@unknown@formal@none@1@S@Isolation and sequencing of the first exon and 5'-flanking region of this gene reveal a TATA-less promoter with a high G + C content.@(((:tag . "NN") (:stem . "isolation") (:form . "Isolation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tata-less") (:form . "TATA-less") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s762.6) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007100@unknown@formal@none@1@S@We transfected promoter-luciferase reporter plasmids into THP-1 cells to define sequences that mediate transcriptional control during monocyte differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "transfecte") (:form . "transfected") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "promoter-luciferase")\n  (:form . "promoter-luciferase") (:end . 34) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 43)\n  (:start . 35) (:id . 45))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 52)\n  (:start . 44) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 57) (:start . 53)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 63) (:start . 58)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 118) (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 126)\n  (:start . 119) (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 133)\n  (:start . 127) (:id . 57))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 142)\n  (:start . 134) (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 158) (:start . 143) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s762.8) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007101@unknown@formal@none@1@S@We found that sequences downstream from the transcriptional start site were sufficient to confer increased expression during THP-1 differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 59) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 146) (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s762.9) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007102@unknown@formal@none@1@S@DNase I footprinting and sequence analysis revealed the existence of multiple AP2 and Sp1 binding sites in the 5'-untranslated and proximal coding regions.@(((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "ap2") (:form . "AP2") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 126) (:start . 111) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s762.10) (:did . :|7706273|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007103@unknown@formal@none@1@S@Functional characterization of novel IL-2 transcriptional inhibitors.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 27) (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 57) (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 68)\n  (:start . 58) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s763.1) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007104@unknown@formal@none@1@S@IL-2-mediated T cell proliferation is a critical early event in the inflammatory process.@(((:tag . "JJ") (:stem . "il-2-mediated") (:form . "IL-2-mediated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s763.2) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007105@unknown@formal@none@1@S@Formation of the NFAT-1 transcriptional complex on the IL-2 promoter is essential for IL-2 transcription.@(((:tag . "NN") (:stem . "formation") (:form . "Formation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s763.3) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007106@unknown@formal@none@1@S@Using a cell line that is stably transfected with a trimer of the NFAT-1 regulatory element linked to a lac-Z reporter gene, we screened for inhibitors of NFAT-1-mediated beta-galactosidase activity.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "trimer") (:form . "trimer") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 98) (:start . 92)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lac-z") (:form . "lac-Z") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "screen") (:form . "screened") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "nfat-1-mediated") (:form . "NFAT-1-mediated")\n  (:end . 170) (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "beta-galactosidase") (:form . "beta-galactosidase")\n  (:end . 189) (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s763.4) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007107@unknown@formal@none@1@S@WIN 61058 and WIN 53071 were identified as microM inhibitors.@(((:tag . "NN") (:stem . "win") (:form . "WIN") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "61058") (:form . "61058") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "WIN") (:form . "WIN") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "53071") (:form . "53071") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s763.5) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007108@unknown@formal@none@1@S@These compounds also inhibited beta-galactosidase mRNA levels.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "beta-galactosidase") (:form . "beta-galactosidase")\n  (:end . 49) (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 54) (:start . 50)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 61)\n  (:start . 55) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s763.6) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007110@unknown@formal@none@1@S@At 10 microM, both compounds inhibited IL-2 mRNA and protein levels in the NFAT-1-linked lac-Z transfectants, and in human lymphocytes.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 12)\n  (:start . 6) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nfat-1-linked") (:form . "NFAT-1-linked")\n  (:end . 88) (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "lac-z") (:form . "lac-Z") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 108) (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 134)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s763.8) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007111@unknown@formal@none@1@S@Both compounds inhibited the mixed lymphocyte reaction, and this inhibition was reversed by exogenous IL-2.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mixed") (:form . "mixed") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s763.9) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007112@unknown@formal@none@1@S@WIN 53071 inhibited IL-2 production induced in the calcium-dependent PMA and ionomycin pathway.@(((:tag . "NN") (:stem . "win") (:form . "WIN") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "53071") (:form . "53071") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 68) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "pma") (:form . "PMA") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s763.10) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007113@unknown@formal@none@1@S@Conversely, calcium-independent anti-CD28 Ab and PMA-induced IL-2 production was resistant.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "calcium-independent")\n  (:form . "calcium-independent") (:end . 31) (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 60)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s763.11) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007114@unknown@formal@none@1@S@Both compounds altered the NFAT-1 transcriptional complex, causing its retarded mobility on gels.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "alter") (:form . "altered") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 49) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "retard") (:form . "retarded") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gel") (:form . "gels") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s763.12) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007115@unknown@formal@none@1@S@By these functional criteria, we believe we have identified two structurally distinct, novel inhibitors of NFAT-1-mediated transcription.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "believe") (:form . "believe") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nfat-1-mediated") (:form . "NFAT-1-mediated")\n  (:end . 122) (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x763.13.1) (:span 33 40)))\n (:hscopes ((:id . :x763.13.1) (:span 33 136)))\n (:identifiers (:sid . :s763.13) (:did . :|7706710|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007116@unknown@formal@none@1@S@cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.@(((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ngfi-b/nur77-related")\n  (:form . "NGFI-B/nur77-related") (:end . 38) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s764.1) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007117@unknown@formal@none@1@S@A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PEER") (:form . "PEER") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "die") (:form . "dies") (:end . 40) (:start . 36)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 52))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 53)\n  (:start . 44) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 69)\n  (:start . 61) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 88)\n  (:start . 81) (:id . 60))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 98)\n  (:start . 89) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s764.2) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007118@unknown@formal@none@1@S@A new gene, TINUR, was cloned from apoptotic PEER cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TINUR") (:form . "TINUR") (:end . 17) (:start . 12)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 29)\n  (:start . 23) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 44)\n  (:start . 35) (:id . 51))\n ((:tag . "NN") (:stem . "peer") (:form . "PEER") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s764.3) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007120@unknown@formal@none@1@S@TINUR belongs to the NGFI-B/nur77 family of the steroid receptor superfamily and is an orphan receptor.@(((:tag . "NNP") (:stem . "TINUR") (:form . "TINUR") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ngfi-b/nur77") (:form . "NGFI-B/nur77") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "orphan") (:form . "orphan") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s764.5) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007121@unknown@formal@none@1@S@TINUR binds to the same DNA sequence as NGFI-B/nur77.@(((:tag . "NNP") (:stem . "TINUR") (:form . "TINUR") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NGFI-B/nur77") (:form . "NGFI-B/nur77") (:end . 52)\n  (:start . 40) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s764.6) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007122@unknown@formal@none@1@S@We also propose that the NGFI-B/nur77 family can be classified into two subtypes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ngfi-b/nur77") (:form . "NGFI-B/nur77") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "classify") (:form . "classified") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "subtype") (:form . "subtypes") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x764.7.1) (:span 8 15)))\n (:hscopes ((:id . :x764.7.1) (:span 8 80)))\n (:identifiers (:sid . :s764.7) (:did . :|7706727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007123@unknown@formal@none@1@S@Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes.@(((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "Platelet-activating") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 26)\n  (:start . 20) (:id . 43))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 37)\n  (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 51) (:start . 38) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "heparin-binding") (:form . "heparin-binding")\n  (:end . 74) (:start . 59) (:id . 48))\n ((:tag . "JJ") (:stem . "epidermal") (:form . "epidermal") (:end . 84)\n  (:start . 75) (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 91)\n  (:start . 85) (:id . 50))\n ((:tag . "JJ") (:stem . "factor-like") (:form . "factor-like") (:end . 103)\n  (:start . 92) (:id . 51))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 110)\n  (:start . 104) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 117)\n  (:start . 111) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 130)\n  (:start . 121) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s765.1) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007124@unknown@formal@none@1@S@Correlation with an increased kappa B binding activity.@(((:tag . "NN") (:stem . "correlation") (:form . "Correlation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s765.2) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007125@unknown@formal@none@1@S@Human peripheral blood monocytes responded to stimulation of platelet-activating factor (PAF) with up-regulation of the transcript for heparin-binding epidermal growth factor-like growth factor (HB-EGF), a potent mitogen for vascular smooth muscle cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 80) (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 87)\n  (:start . 81) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 112) (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "heparin-binding") (:form . "heparin-binding")\n  (:end . 150) (:start . 135) (:id . 61))\n ((:tag . "JJ") (:stem . "epidermal") (:form . "epidermal") (:end . 160)\n  (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 167)\n  (:start . 161) (:id . 63))\n ((:tag . "JJ") (:stem . "factor-like") (:form . "factor-like") (:end . 179)\n  (:start . 168) (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 186)\n  (:start . 180) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 193)\n  (:start . 187) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HB-EGF") (:form . "HB-EGF") (:end . 201)\n  (:start . 195) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 205) (:start . 204)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 212)\n  (:start . 206) (:id . 72))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 220)\n  (:start . 213) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 224) (:start . 221)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 233)\n  (:start . 225) (:id . 75))\n ((:tag . "JJ") (:stem . "smooth") (:form . "smooth") (:end . 240)\n  (:start . 234) (:id . 76))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 247)\n  (:start . 241) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 253)\n  (:start . 248) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s765.3) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007126@unknown@formal@none@1@S@This function of PAF was observed at nanomolar concentrations of the ligand, starting at 30 min after stimulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nanomolar") (:form . "nanomolar") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 61) (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "start") (:form . "starting") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 113)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s765.4) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007127@unknown@formal@none@1@S@The PAF-induced up-regulation of HB-EGF mRNA was accompanied by an increase in kappa B binding activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "paf-induced") (:form . "PAF-induced") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HB-EGF") (:form . "HB-EGF") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s765.5) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007128@unknown@formal@none@1@S@These functions of PAF appeared to be mediated through the cell surface PAF receptors, as two PAF receptor antagonists, WEB 2086 and L-659,989, blocked both the up-regulation of HB-EGF mRNA and kappa B binding activity induced by PAF.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 118)\n  (:start . 107) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "WEB") (:form . "WEB") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "CD") (:stem . "2086") (:form . "2086") (:end . 128) (:start . 124)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "L-659,989") (:form . "L-659,989") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 174) (:start . 161) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HB-EGF") (:form . "HB-EGF") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 189) (:start . 185)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "kappa") (:form . "kappa") (:end . 199)\n  (:start . 194) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 201) (:start . 200)\n  (:id . 77))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 209)\n  (:start . 202) (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 218)\n  (:start . 210) (:id . 79))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 226)\n  (:start . 219) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 229) (:start . 227)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 233) (:start . 230)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x765.6.1) (:span 23 31)))\n (:hscopes ((:id . :x765.6.1) (:span 0 85)))\n (:identifiers (:sid . :s765.6) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007130@unknown@formal@none@1@S@Pretreatment of monocytes with pertussis toxin inhibited these functions of PAF, whereas cholera toxin had no inhibitory effect.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pertussis") (:form . "pertussis") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "cholera") (:form . "cholera") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x765.8.1) (:span 107 109)))\n (:nscopes ((:id . :x765.8.1) (:span 107 127)))\n (:identifiers (:sid . :s765.8) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007131@unknown@formal@none@1@S@Pyrrolidine dithiocarbamate, an inhibitor for NF-kappa B activation, markedly reduced PAF-stimulated kappa B binding activity as well as up-regulation of HB-EGF mRNA.@(((:tag . "NNP") (:stem . "Pyrrolidine") (:form . "Pyrrolidine") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "paf-stimulated") (:form . "PAF-stimulated")\n  (:end . 100) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 150) (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HB-EGF") (:form . "HB-EGF") (:end . 160)\n  (:start . 154) (:id . 64))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s765.9) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007132@unknown@formal@none@1@S@These results suggest a potential role of PAF in HB-EGF expression and provide evidence that this stimulation may occur through increased kappa B binding activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HB-EGF") (:form . "HB-EGF") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x765.10.1) (:span 110 113))\n  ((:id . :x765.10.2) (:span 24 33)) ((:id . :x765.10.3) (:span 14 21)))\n (:hscopes ((:id . :x765.10.1) (:span 110 162))\n  ((:id . :x765.10.2) (:span 24 66)) ((:id . :x765.10.3) (:span 14 66)))\n (:identifiers (:sid . :s765.10) (:did . :|7713868|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007133@unknown@formal@none@1@S@IL-1 receptor and TCR signals synergize to activate NF-kappa B-mediated gene transcription.@(((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s766.1) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007134@unknown@formal@none@1@S@Previous studies have demonstrated that IL-1 receptor (IL-1R)- and TCR-initiated signals can interact synergistically to increase the rate of transcription of several lymphokine and lymphokine receptor genes during the competence phase of the activation program in T helper lymphocytes.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-1R)-") (:form . "IL-1R)-") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tcr-initiated") (:form . "TCR-initiated")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 117) (:start . 102) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 129)\n  (:start . 121) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 155) (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 177)\n  (:start . 167) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 192)\n  (:start . 182) (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 201)\n  (:start . 193) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 207)\n  (:start . 202) (:id . 69))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 214)\n  (:start . 208) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 71))\n ((:tag . "NN") (:stem . "competence") (:form . "competence") (:end . 229)\n  (:start . 219) (:id . 72))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 235)\n  (:start . 230) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 242) (:start . 239)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 253)\n  (:start . 243) (:id . 76))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 261)\n  (:start . 254) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 266) (:start . 265)\n  (:id . 79))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 273)\n  (:start . 267) (:id . 80))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 285)\n  (:start . 274) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s766.2) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007135@unknown@formal@none@1@S@In this report we describe how signals initiated through the type I IL-1R interact with signals from the antigen receptor to synergistically augment the transactivating properties of NF-kappa B.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-1r") (:form . "IL-1R") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 140) (:start . 125) (:id . 63))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 168) (:start . 153) (:id . 66))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 179)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s766.3) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007136@unknown@formal@none@1@S@The synergistic antigen receptor initiated signals are mediated through protein kinase C because they can be mimicked by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, but not with calcium ionophores; and are staurosporine sensitive but cyclosporine resistant.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 86)\n  (:start . 80) (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mimic") (:form . "mimicked") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 176) (:start . 140)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 185) (:start . 182)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 190) (:start . 186)\n  (:id . 68))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 198)\n  (:start . 191) (:id . 69))\n ((:tag . "NNS") (:stem . "ionophore") (:form . "ionophores") (:end . 209)\n  (:start . 199) (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 210) (:start . 209)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 218) (:start . 215)\n  (:id . 73))\n ((:tag . "NN") (:stem . "staurosporine") (:form . "staurosporine")\n  (:end . 232) (:start . 219) (:id . 74))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 242)\n  (:start . 233) (:id . 75))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 246) (:start . 243)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 259)\n  (:start . 247) (:id . 77))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 269)\n  (:start . 260) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x766.4.1) (:span 182 185)))\n (:nscopes ((:id . :x766.4.1) (:span 182 209)))\n (:identifiers (:sid . :s766.4) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007137@unknown@formal@none@1@S@Gel shift analyses demonstrate that NF-kappa B nuclear translocation is stimulated primarily by IL-1 rather than by antigen receptor signals.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 68) (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x766.5.1) (:span 101 112)))\n (:nscopes ((:id . :x766.5.1) (:span 101 140)))\n (:identifiers (:sid . :s766.5) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007138@unknown@formal@none@1@S@Western blot and phosphorylation analyses demonstrate that the synergistic effect on NF-kappa B functional activity is independent of I kappa B alpha (MAD3)-NF-kappa B dissociation in the cytosol and is not associated with I kappa B nuclear translocation.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 74)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 115)\n  (:start . 107) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 130)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "MAD3)-NF-kappa") (:form . "MAD3)-NF-kappa")\n  (:end . 165) (:start . 151) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 180)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 195)\n  (:start . 188) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 206) (:start . 203)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 217)\n  (:start . 207) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 222) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 224) (:start . 223)\n  (:id . 76))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 230)\n  (:start . 225) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 232) (:start . 231)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 240)\n  (:start . 233) (:id . 79))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 254) (:start . 241) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x766.6.1) (:span 203 206)))\n (:nscopes ((:id . :x766.6.1) (:span 200 254)))\n (:identifiers (:sid . :s766.6) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007140@unknown@formal@none@1@S@These results suggest that IL-1 induces both NF-kappa B nuclear translocation and the synthesis of a protein(s) responsible for terminating NF-kappa B-DNA interaction in the nucleus.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "protein(s)") (:form . "protein(s)") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 123)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "terminate") (:form . "terminating") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 148)\n  (:start . 140) (:id . 62))\n ((:tag . "NNP") (:stem . "B-DNA") (:form . "B-DNA") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 166)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 181)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x766.8.1) (:span 14 21)))\n (:hscopes ((:id . :x766.8.1) (:span 14 181)))\n (:identifiers (:sid . :s766.8) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007141@unknown@formal@none@1@S@Antigen receptor signals prolong NF-kappa B-DNA interaction, probably by functionally antagonizing the IL-1-induced synthesis of a protein(s) responsible for the transient NF-kappa B-DNA interaction and consequently synergistically enhance IL-1-induced NF-kappa B-dependent gene transcription.@(((:tag . "NN") (:stem . "antigen") (:form . "Antigen") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "prolong") (:form . "prolong") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "B-DNA") (:form . "B-DNA") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 85)\n  (:start . 73) (:id . 52))\n ((:tag . "VBG") (:stem . "antagonize") (:form . "antagonizing") (:end . 98)\n  (:start . 86) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 115)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 125)\n  (:start . 116) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "protein(s)") (:form . "protein(s)") (:end . 141)\n  (:start . 131) (:id . 59))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 153)\n  (:start . 142) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 171)\n  (:start . 162) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 180)\n  (:start . 172) (:id . 64))\n ((:tag . "NNP") (:stem . "B-DNA") (:form . "B-DNA") (:end . 186)\n  (:start . 181) (:id . 65))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 198)\n  (:start . 187) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 67))\n ((:tag . "RB") (:stem . "consequently") (:form . "consequently") (:end . 215)\n  (:start . 203) (:id . 68))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 231) (:start . 216) (:id . 69))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 239)\n  (:start . 232) (:id . 70))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 252)\n  (:start . 240) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 261)\n  (:start . 253) (:id . 72))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 273)\n  (:start . 262) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 278) (:start . 274)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 292) (:start . 279) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x766.9.1) (:span 61 69)))\n (:hscopes ((:id . :x766.9.1) (:span 61 198)))\n (:identifiers (:sid . :s766.9) (:did . :|7718519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007142@unknown@formal@none@1@S@Induction of transcription factors in human T lymphocytes by aspirin-like drugs.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "aspirin-like") (:form . "aspirin-like") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s767.1) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007143@unknown@formal@none@1@S@Aspirin-like drugs (ALD) induce calcium mobilization, an essential component of T cell activation, but do not induce the biosynthesis of IL-2.@(((:tag . "JJ") (:stem . "aspirin-like") (:form . "Aspirin-like") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ALD") (:form . "ALD") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 52)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "biosynthesis") (:form . "biosynthesis") (:end . 133)\n  (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x767.2.1) (:span 106 109)))\n (:nscopes ((:id . :x767.2.1) (:span 106 141)))\n (:identifiers (:sid . :s767.2) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007144@unknown@formal@none@1@S@To understand the extent to which ALD may mimic mitogenic stimulation, we studied cytoplasmic and nuclear signaling steps in ALD-treated T cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ALD") (:form . "ALD") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ald-treated") (:form . "ALD-treated") (:end . 136)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x767.3.1) (:span 38 41)))\n (:hscopes ((:id . :x767.3.1) (:span 38 69)))\n (:identifiers (:sid . :s767.3) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007145@unknown@formal@none@1@S@We found that ALD induce a transient activation of protein kinase (PKC) but have no effect (in comparison to anti-CD3 antibodies) on protein tyrosine phosphorylation nor on PCL gamma 1 tyrosine phosphorylation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ald") (:form . "ALD") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 90)\n  (:start . 84) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 105)\n  (:start . 95) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 117)\n  (:start . 109) (:id . 64))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 128)\n  (:start . 118) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 68))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 149)\n  (:start . 141) (:id . 69))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 165) (:start . 150) (:id . 70))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 172) (:start . 170)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PCL") (:form . "PCL") (:end . 176) (:start . 173)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 182)\n  (:start . 177) (:id . 74))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 184) (:start . 183)\n  (:id . 75))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 193)\n  (:start . 185) (:id . 76))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 209) (:start . 194) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x767.4.1) (:span 81 83 166 169)))\n (:nscopes ((:id . :x767.4.1) (:span 81 209)))\n (:identifiers (:sid . :s767.4) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007146@unknown@formal@none@1@S@ALD-induced calcium mobilization and PKC activation are independent of tyrosine protein kinase activity as shown by the lack of effect of herbimycin, a tyrosine-protein kinase-specific inhibitor.@(((:tag . "JJ") (:stem . "ald-induced") (:form . "ALD-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 67)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 148)\n  (:start . 138) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "tyrosine-protein") (:form . "tyrosine-protein")\n  (:end . 168) (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "kinase-specific") (:form . "kinase-specific")\n  (:end . 184) (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 194)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x767.5.1) (:span 120 124)))\n (:nscopes ((:id . :x767.5.1) (:span 120 194)))\n (:identifiers (:sid . :s767.5) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007147@unknown@formal@none@1@S@Although we detected no IL-2 mRNA in ALD-treated cells, the nuclei of these cells contain proteins capable of binding to three regulatory sequences in the IL-2 promoter region: NFAT, NF kappa B, and AP-1.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ald-treated") (:form . "ALD-treated") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 175)\n  (:start . 169) (:id . 70))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 181) (:start . 177)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 185) (:start . 183)\n  (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 191)\n  (:start . 186) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 78))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 203) (:start . 199)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x767.6.1) (:span 21 23)))\n (:nscopes ((:id . :x767.6.1) (:span 21 54)))\n (:identifiers (:sid . :s767.6) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007148@unknown@formal@none@1@S@These binding activities are expressed only in activated T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s767.7) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007150@unknown@formal@none@1@S@These data suggest that ALD cause transient but significant changes in T cell transmembrane signaling, although some events induced by stimulation with anti-CD3 antibodies are not induced by ALD.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ald") (:form . "ALD") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 91) (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 146)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 171)\n  (:start . 161) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "ALD") (:form . "ALD") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x767.9.2) (:span 11 18)))\n (:ncues ((:id . :x767.9.1) (:span 176 179)))\n (:hscopes ((:id . :x767.9.2) (:span 11 101)))\n (:nscopes ((:id . :x767.9.1) (:span 112 194)))\n (:identifiers (:sid . :s767.9) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007151@unknown@formal@none@1@S@The signal is transmitted to the nucleus and induces DNA-binding activity by several transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "transmit") (:form . "transmitted") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s767.10) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007152@unknown@formal@none@1@S@However, the ALD stimulus is not capable of causing complete T cell activation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ALD") (:form . "ALD") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x767.11.1) (:span 29 32)))\n (:nscopes ((:id . :x767.11.1) (:span 29 78)))\n (:identifiers (:sid . :s767.11) (:did . :|7720085|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007153@unknown@formal@none@1@S@Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL)-10") (:form . "IL)-10") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s768.1) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007154@unknown@formal@none@1@S@IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s768.2) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007155@unknown@formal@none@1@S@Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines, IL-1 beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha by blocking gene transcription.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL)-10") (:form . "IL)-10") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 110) (:start . 92) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "LPS)-stimulated") (:form . "LPS)-stimulated")\n  (:end . 127) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 138)\n  (:start . 128) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 154)\n  (:start . 142) (:id . 60))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 164)\n  (:start . 155) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 170) (:start . 166)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 175) (:start . 171)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 181) (:start . 177)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 187) (:start . 183)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 198)\n  (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 207)\n  (:start . 199) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 214)\n  (:start . 208) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 216) (:start . 215)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TNF)-alpha") (:form . "TNF)-alpha") (:end . 226)\n  (:start . 216) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 238)\n  (:start . 230) (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 243) (:start . 239)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 257) (:start . 244) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s768.3) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007156@unknown@formal@none@1@S@Using electrophoretic mobility shift assays (EMSA), we now show that, in monocytes stimulated with LPS or TNF alpha, IL-10 inhibits nuclear stimulation of nuclear factor kappa B (NF kappa B), a transcription factor involved in the expression of inflammatory cytokine genes.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . 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"a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 207) (:start . 194) (:id . 81))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 214)\n  (:start . 208) (:id . 82))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 223)\n  (:start . 215) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 85))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 241)\n  (:start . 231) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 244) (:start . 242)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 257)\n  (:start . 245) (:id . 88))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 266)\n  (:start . 258) (:id . 89))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 272)\n  (:start . 267) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s768.4) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007157@unknown@formal@none@1@S@Several other transcription factors including NF-IL-6, AP-1, AP-2, GR, CREB, Oct-1, and Sp-1 are not affected by IL-10.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-IL-6") (:form . "NF-IL-6") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-2") (:form . "AP-2") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Sp-1") (:form . "Sp-1") (:end . 92) (:start . 88)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 109)\n  (:start . 101) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 118)\n  (:start . 113) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x768.5.1) (:span 97 100)))\n (:nscopes ((:id . :x768.5.1) (:span 0 118)))\n (:identifiers (:sid . :s768.5) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007158@unknown@formal@none@1@S@This selective inhibition by IL-10 of NF kappa B activation occurs rapidly and in a dose-dependent manner and correlates well with IL-10's cytokine synthesis inhibitory activity in terms of both kinetics and dose responsiveness.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 98) (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 157)\n  (:start . 148) (:id . 66))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 194) (:start . 190)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 203)\n  (:start . 195) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 212) (:start . 208)\n  (:id . 75))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 227) (:start . 213) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s768.6) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007160@unknown@formal@none@1@S@Taken together, these results suggest that inhibition of NF kappa B activation may be an important mechanism for IL-10 suppression of cytokine gene transcription in human monocytes.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 161) (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 180)\n  (:start . 171) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x768.8.1) (:span 79 82)) ((:id . :x768.8.2) (:span 30 37)))\n (:hscopes ((:id . :x768.8.1) (:span 79 180))\n  ((:id . :x768.8.2) (:span 30 180)))\n (:identifiers (:sid . :s768.8) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007161@unknown@formal@none@1@S@IL-4, another cytokine that inhibits cytokine mRNA accumulation in monocytes, shows little inhibitory effect on LPS-induced NF kappa B activation.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 123)\n  (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s768.9) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007162@unknown@formal@none@1@S@Further examination reveals that, unlike IL-10, IL-4 enhances mRNA degradation and does not suppress cytokine gene transcription.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "examination") (:form . "examination") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x768.10.1) (:span 88 91)))\n (:nscopes ((:id . :x768.10.1) (:span 88 128)))\n (:identifiers (:sid . :s768.10) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007163@unknown@formal@none@1@S@These data indicate that IL-10 and IL-4 inhibit cytokine production by different mechanisms.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x768.11.1) (:span 11 24)))\n (:hscopes ((:id . :x768.11.1) (:span 11 91)))\n (:identifiers (:sid . :s768.11) (:did . :|7721885|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007164@unknown@formal@none@1@S@Activation of transcription by binding of NF-E1 (YY1) to a newly identified element in the first exon of the human DR alpha gene.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-E1") (:form . "NF-E1") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "YY1") (:form . "YY1") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "dr") (:form . "DR") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s769.1) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007165@unknown@formal@none@1@S@A previously unrecognized element, located downstream of the start site of transcription in the first exon of the DR alpha gene, has been defined that enhances promoter activity up to eightfold in a position-dependent manner.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "unrecognized") (:form . "unrecognized") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DR") (:form . "DR") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "VB") (:stem . "eightfold") (:form . "eightfold") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 198) (:start . 197)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "position-dependent") (:form . "position-dependent")\n  (:end . 217) (:start . 199) (:id . 77))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 224)\n  (:start . 218) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s769.2) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007166@unknown@formal@none@1@S@Mutations in this DNA-binding site abolished binding of a nuclear factor in human B cell nuclear extract and decreased the activity of the DR alpha promoter to a basal level.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DR") (:form . "DR") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 167)\n  (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 173)\n  (:start . 168) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s769.3) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007167@unknown@formal@none@1@S@Significant sequence homology of this element was found in the DNA of the DR beta, DP alpha and -beta, and DQ alpha genes, always located downstream of the transcriptional start site.@(((:tag . "JJ") (:stem . "significant") (:form . "Significant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DR") (:form . "DR") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 101) (:start . 96)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DQ") (:form . "DQ") (:end . 109) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 115)\n  (:start . 110) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 121)\n  (:start . 116) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 67))\n ((:tag . "RB") (:stem . "always") (:form . "always") (:end . 129)\n  (:start . 123) (:id . 68))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 137)\n  (:start . 130) (:id . 69))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 148)\n  (:start . 138) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 171) (:start . 156) (:id . 73))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 177)\n  (:start . 172) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 182) (:start . 178)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s769.4) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007168@unknown@formal@none@1@S@The nuclear factor binds to the DR alpha and DP alpha element but not to the element in the DQ alpha gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DR") (:form . "DR") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DQ") (:form . "DQ") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x769.5.1) (:span 66 69)))\n (:nscopes ((:id . :x769.5.1) (:span 66 105)))\n (:identifiers (:sid . :s769.5) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007170@unknown@formal@none@1@S@This protein, previously identified by its binding to the Ig kappa 3' enhancer and the Ig heavy chain mu E1 site, thus also appears to be quite important in the regulation of MHC class II gene expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 101) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "e1") (:form . "E1") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 65))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 118) (:start . 114)\n  (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 123) (:start . 119)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 131)\n  (:start . 124) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 137) (:start . 135)\n  (:id . 70))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 143)\n  (:start . 138) (:id . 71))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 153)\n  (:start . 144) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 74))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 171)\n  (:start . 161) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 178) (:start . 175)\n  (:id . 77))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 184)\n  (:start . 179) (:id . 78))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 187) (:start . 185)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 192) (:start . 188)\n  (:id . 80))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 203)\n  (:start . 193) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x769.7.1) (:span 124 131)))\n (:hscopes ((:id . :x769.7.1) (:span 0 203)))\n (:identifiers (:sid . :s769.7) (:did . :|7730624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007171@unknown@formal@none@1@S@Mouse interleukin-2 receptor alpha gene expression.@(((:tag . "NNP") (:stem . "Mouse") (:form . "Mouse") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s770.1) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007172@unknown@formal@none@1@S@Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.@(((:tag . "NN") (:stem . "interleukin-1") (:form . "Interleukin-1")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 57) (:start . 54)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 66)\n  (:start . 58) (:id . 48))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 77)\n  (:start . 67) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 86)\n  (:start . 78) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s770.2) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007173@unknown@formal@none@1@S@We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cd4-cd8-") (:form . "CD4-CD8-") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 152)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s770.3) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007174@unknown@formal@none@1@S@Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma (PC60).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "map") (:form . "map") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 75) (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 111) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoma-derived") (:form . "lymphoma-derived")\n  (:end . 137) (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "hybridoma") (:form . "hybridoma") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PC60") (:form . "PC60") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s770.4) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007175@unknown@formal@none@1@S@The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s770.5) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007176@unknown@formal@none@1@S@IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation.@(((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "synthesis-independent")\n  (:form . "synthesis-independent") (:end . 51) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s770.6) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007177@unknown@formal@none@1@S@It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "prim") (:form . "primes") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "VBZ") (:stem . "prepare") (:form . "prepares") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "RB") (:stem . "100-fold") (:form . "100-fold") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 162)\n  (:start . 151) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s770.7) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007178@unknown@formal@none@1@S@Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 34)\n  (:start . 23) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 39) (:start . 35)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "promoter-proximal") (:form . "promoter-proximal")\n  (:end . 86) (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 93)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 128)\n  (:start . 118) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 151) (:start . 137) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 62))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "RB") (:stem . "importantly") (:form . "importantly") (:end . 169)\n  (:start . 158) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 181)\n  (:start . 173) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 198)\n  (:start . 189) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 211)\n  (:start . 206) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 73))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 221)\n  (:start . 216) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 226) (:start . 222)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s770.8) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007180@unknown@formal@none@1@S@This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "il-2-inducible") (:form . "IL-2-inducible")\n  (:end . 43) (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 113) (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 180)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s770.10) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007181@unknown@formal@none@1@S@IL-2 responsiveness requires three distinct elements within the enhancer.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s770.11) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007182@unknown@formal@none@1@S@Two of these are potential binding sites for STAT proteins.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x770.12.1) (:span 17 26)))\n (:hscopes ((:id . :x770.12.1) (:span 17 58)))\n (:identifiers (:sid . :s770.12) (:did . :|7738013|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007183@unknown@formal@none@1@S@Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation.@(((:tag . "NN") (:stem . "coupling") (:form . "Coupling") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s771.1) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007184@unknown@formal@none@1@S@The eukaryotic transcription factor NF-kappa B plays a central role in the induced expression of human immunodeficiency virus type 1 and in many aspects of the genetic program mediating normal T-cell activation and growth.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 119) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 185)\n  (:start . 176) (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 192)\n  (:start . 186) (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 199)\n  (:start . 193) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 210)\n  (:start . 200) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 74))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 221)\n  (:start . 215) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s771.2) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007185@unknown@formal@none@1@S@The nuclear activity of NF-kappa B is tightly regulated from the cytoplasmic compartment by an inhibitory subunit called I kappa B alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s771.3) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007186@unknown@formal@none@1@S@This cytoplasmic inhibitor is rapidly phosphorylated and degraded in response to a diverse set of NF-kappa B-inducing agents, including T-cell mitogens, proinflammatory cytokines, and viral transactivators such as the Tax protein of human T-cell leukemia virus type 1.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 52) (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "b-inducing") (:form . "B-inducing") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 168) (:start . 153) (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 178)\n  (:start . 169) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 189)\n  (:start . 184) (:id . 69))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 205) (:start . 190) (:id . 70))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 210) (:start . 206)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 221) (:start . 218)\n  (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 229)\n  (:start . 222) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 238)\n  (:start . 233) (:id . 77))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 245)\n  (:start . 239) (:id . 78))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 254)\n  (:start . 246) (:id . 79))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 260)\n  (:start . 255) (:id . 80))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 265) (:start . 261)\n  (:id . 81))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 267) (:start . 266)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s771.4) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007187@unknown@formal@none@1@S@To explore these I kappa B alpha-dependent mechanisms for NF-kappa B induction, we identified novel mutants of I kappa B alpha that uncouple its inhibitory and signal-transducing functions in human T lymphocytes.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "alpha-dependent") (:form . "alpha-dependent")\n  (:end . 42) (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "uncouple") (:form . "uncouple") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 155)\n  (:start . 145) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "signal-transducing") (:form . "signal-transducing")\n  (:end . 178) (:start . 160) (:id . 69))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 188)\n  (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 197)\n  (:start . 192) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 211)\n  (:start . 200) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s771.5) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007188@unknown@formal@none@1@S@Specifically, removal of the N-terminal 36 amino acids of I kappa B alpha failed to disrupt its ability to form latent complexes with NF-kappa B in the cytoplasm.@(((:tag . "RB") (:stem . "specifically") (:form . "Specifically") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 80) (:start . 74)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 91)\n  (:start . 84) (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 118)\n  (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 161)\n  (:start . 152) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x771.6.1) (:span 74 80)))\n (:nscopes ((:id . :x771.6.1) (:span 74 161)))\n (:identifiers (:sid . :s771.6) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007190@unknown@formal@none@1@S@Alanine substitutions introduced at two serine residues positioned within this N-terminal regulatory region of I kappa B alpha also yielded constitutive repressors that escaped from Tax-induced turnover and that potently inhibited immune activation pathways for NF-kappa B induction, including those initiated from antigen and cytokine receptors.@(((:tag . "NNP") (:stem . "Alanine") (:form . "Alanine") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . 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"turnover") (:end . 202)\n  (:start . 194) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 211) (:start . 207)\n  (:id . 70))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 220)\n  (:start . 212) (:id . 71))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 230)\n  (:start . 221) (:id . 72))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 237)\n  (:start . 231) (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 248)\n  (:start . 238) (:id . 74))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 257)\n  (:start . 249) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 261) (:start . 258)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 270)\n  (:start . 262) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 272) (:start . 271)\n  (:id . 78))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 282)\n  (:start . 273) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 283) (:start . 282)\n  (:id . 80))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 293)\n  (:start . 284) (:id . 81))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 299)\n  (:start . 294) (:id . 82))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 309)\n  (:start . 300) (:id . 83))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 314) (:start . 310)\n  (:id . 84))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 322)\n  (:start . 315) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 326) (:start . 323)\n  (:id . 86))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 335)\n  (:start . 327) (:id . 87))\n ((:tag . "NNS") (:stem . "receptor") (:form . 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5007191@unknown@formal@none@1@S@In contrast, introduction of a phosphoserine mimetic at these sites rectified this functional defect, a finding consistent with a causal linkage between the phosphorylation status and proteolytic stability of this cytoplasmic inhibitor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "introduction") (:form . "introduction") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphoserine") (:form . "phosphoserine")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "mimetic") (:form . "mimetic") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "rectify") (:form . "rectified") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "causal") (:form . "causal") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "linkage") (:form . "linkage") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 172) (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 179)\n  (:start . 173) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 195)\n  (:start . 184) (:id . 70))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 205)\n  (:start . 196) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 213) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 225)\n  (:start . 214) (:id . 74))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 235)\n  (:start . 226) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s771.9) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007192@unknown@formal@none@1@S@Together, these in vivo studies define a critical signal response domain in I kappa B alpha that coordinately controls the biologic activities of I kappa B alpha and NF-kappa B in response to viral and immune stimuli.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 109)\n  (:start . 97) (:id . 60))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 161)\n  (:start . 156) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 174)\n  (:start . 166) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 188)\n  (:start . 180) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 197)\n  (:start . 192) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 208)\n  (:start . 202) (:id . 78))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 216)\n  (:start . 209) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s771.10) (:did . :|7739562|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007193@unknown@formal@none@1@S@HIV type 1 protease activation of NF-kappa B within T lymphoid cells.@(((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s772.1) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007194@unknown@formal@none@1@S@NF-kappa B is a nuclear protein of the rel oncogene family capable of enhancing transcription of several cellular genes, including IL-2 and the IL-2 receptor, and viral genes transcribed from the HIV-1 LTR.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 186)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 191) (:start . 187)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 201)\n  (:start . 196) (:id . 75))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s772.2) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007195@unknown@formal@none@1@S@It has been reported that HIV-1 protease may cleave the NF-kappa B precursor to its active form in vitro.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "cleave") (:form . "cleave") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x772.3.1) (:span 41 44)))\n (:hscopes ((:id . :x772.3.1) (:span 41 104)))\n (:identifiers (:sid . :s772.3) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007196@unknown@formal@none@1@S@In this study the effects of HIV protease on NF-kappa B precursor activation were examined in Jurkat T cells by introducing a protease expression vector into the cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "introduce") (:form . "introducing") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s772.4) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007197@unknown@formal@none@1@S@Increased NF-kappa B activity was observed and this increased activity was blocked by a specific inhibitor of the viral protease.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s772.5) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007198@unknown@formal@none@1@S@Viral transcription, as measured using LTR-CAT assays, was only slightly enhanced in the HIV-protease expressing cells, while secretion of IL-2 and expression of the IL-2 receptor were not affected.@(((:tag . "JJ") (:stem . "viral") (:form . "Viral") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LTR-CAT") (:form . "LTR-CAT") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hiv-protease") (:form . "HIV-protease") (:end . 101)\n  (:start . 89) (:id . 57))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x772.6.1) (:span 185 188)))\n (:nscopes ((:id . :x772.6.1) (:span 126 197)))\n (:identifiers (:sid . :s772.6) (:did . :|7742037|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007200@unknown@formal@none@1@S@The retinoblastoma gene product negatively regulates transcriptional activation mediated by the human cytomegalovirus IE2 protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 68) (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 88)\n  (:start . 80) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 117) (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "ie2") (:form . "IE2") (:end . 121) (:start . 118)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s773.1) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007201@unknown@formal@none@1@S@The IE2 gene product of human cytomegalovirus (HCMV) is one of a few viral regulatory proteins expressed immediately upon infection of the host cell.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ie2") (:form . "IE2") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 45) (:start . 30) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 74) (:start . 69)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 85)\n  (:start . 75) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 59))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s773.2) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007202@unknown@formal@none@1@S@It is a potent transcriptional activator of many viral and cellular promoters.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 14) (:start . 8)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 30) (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s773.3) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007203@unknown@formal@none@1@S@We found that the retinoblastoma susceptibility gene product (Rb) dramatically suppressed this IE2 transactivation of various promoters.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 78)\n  (:start . 66) (:id . 53))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ie2") (:form . "IE2") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 114) (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s773.4) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007204@unknown@formal@none@1@S@However, unlike another tumor suppressor protein, p53, Rb did not have any significant effect on basal levels of transcription, suggesting that Rb specifically interacts with IE2 rather than other cellular factors involved in the general transcription machinery.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 86)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 126) (:start . 113) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 138)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 159)\n  (:start . 147) (:id . 68))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 169)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ie2") (:form . "IE2") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 185)\n  (:start . 179) (:id . 72))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 205)\n  (:start . 197) (:id . 75))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 213)\n  (:start . 206) (:id . 76))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 222)\n  (:start . 214) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 225) (:start . 223)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 237)\n  (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 251) (:start . 238) (:id . 81))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 261)\n  (:start . 252) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x773.5.2) (:span 128 138)))\n (:ncues ((:id . :x773.5.1) (:span 179 190)))\n (:hscopes ((:id . :x773.5.2) (:span 128 261)))\n (:nscopes ((:id . :x773.5.1) (:span 179 261)))\n (:identifiers (:sid . :s773.5) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007205@unknown@formal@none@1@S@We found by protein-affinity chromatography that Rb in nuclear extracts or produced by in vitro translation directly bound to IE2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "protein-affinity") (:form . "protein-affinity")\n  (:end . 28) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 43) (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ie2") (:form . "IE2") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s773.6) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007206@unknown@formal@none@1@S@Our results suggest that Rb may regulate the life cycle of HCMV, which is endemic in the human population.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "endemic") (:form . "endemic") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 105)\n  (:start . 95) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x773.7.1) (:span 28 31)) ((:id . :x773.7.2) (:span 12 19)))\n (:hscopes ((:id . :x773.7.1) (:span 28 105))\n  ((:id . :x773.7.2) (:span 12 105)))\n (:identifiers (:sid . :s773.7) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007207@unknown@formal@none@1@S@Furthermore, these data may provide new insights into the slow rate of HCMV DNA replication in cells and the possible involvement of HCMV in tumorigenesis.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 91)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 129)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HCMV") (:form . "HCMV") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tumorigenesis") (:form . "tumorigenesis")\n  (:end . 154) (:start . 141) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x773.8.1) (:span 109 117))\n  ((:id . :x773.8.2) (:span 24 27)))\n (:hscopes ((:id . :x773.8.1) (:span 109 154))\n  ((:id . :x773.8.2) (:span 24 154)))\n (:identifiers (:sid . :s773.8) (:did . :|7747417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007208@unknown@formal@none@1@S@Epstein-Barr virus replicative gene transcription during de novo infection of human thymocytes: simultaneous early expression of BZLF-1 and its repressor RAZ.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 56)\n  (:start . 50) (:id . 47))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 108)\n  (:start . 96) (:id . 55))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "BZLF-1") (:form . "BZLF-1") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 153)\n  (:start . 144) (:id . 62))\n ((:tag . "NNP") (:stem . "RAZ") (:form . "RAZ") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s774.1) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007210@unknown@formal@none@1@S@We and others have shown that EBV can also infect a subset of thymocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "VB") (:stem . "infect") (:form . "infect") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 72)\n  (:start . 62) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s774.3) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007211@unknown@formal@none@1@S@Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s774.4) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007212@unknown@formal@none@1@S@Circularization of the EBV genome was not detected.@(((:tag . "NN") (:stem . "circularization") (:form . "Circularization")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x774.5.1) (:span 38 41)))\n (:nscopes ((:id . :x774.5.1) (:span 0 50)))\n (:identifiers (:sid . :s774.5) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007213@unknown@formal@none@1@S@This is in contrast to the infection in B cells where the genome can circularize within 24 hr of infection.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "VB") (:stem . "circularize") (:form . "circularize") (:end . 80)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 106)\n  (:start . 97) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s774.6) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007214@unknown@formal@none@1@S@The appearance of the BamHI ZLF-1 gene product, ZEBRA, by RT-PCR, was observed within 8 hr of infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BamHI") (:form . "BamHI") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "zlf-1") (:form . "ZLF-1") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 78)\n  (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 85)\n  (:start . 79) (:id . 58))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 90) (:start . 88)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 103)\n  (:start . 94) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s774.7) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007215@unknown@formal@none@1@S@The appearance of a novel fusion transcript (RAZ), which comprised regions of the BZLF-1 locus and the adjacent BRLF-1 locus, was detected by RT-PCR.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAZ") (:form . "RAZ") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "comprise") (:form . "comprised") (:end . 66)\n  (:start . 57) (:id . 54))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bzlf-1") (:form . "BZLF-1") (:end . 88)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 111)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "brlf-1") (:form . "BRLF-1") (:end . 118)\n  (:start . 112) (:id . 63))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 138)\n  (:start . 130) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 148)\n  (:start . 142) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s774.8) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007216@unknown@formal@none@1@S@ZEBRA protein was also identified in infected thymocytes by immunoprecipitation.@(((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 79) (:start . 60) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s774.9) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007217@unknown@formal@none@1@S@In addition, we demonstrated that the EBNA-1 gene in infected thymocytes was transcribed from the Fp promoter, rather than from the Cp/Wp promoter which is used in latently infected B cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 28)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ebna-1") (:form . "EBNA-1") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Fp") (:form . "Fp") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Cp/Wp") (:form . "Cp/Wp") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 172)\n  (:start . 164) (:id . 71))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x774.10.1) (:span 111 122)))\n (:nscopes ((:id . :x774.10.1) (:span 111 189)))\n (:identifiers (:sid . :s774.10) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007218@unknown@formal@none@1@S@Transcripts encoding gp350/220, the major coat protein of EBV, were identified, but we did not find any evidence of transcription from the LMP-2A or EBER-1 loci in infected thymocytes.@(((:tag . "NNS") (:stem . "transcript") (:form . "Transcripts") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "gp350/220") (:form . "gp350/220") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "coat") (:form . "coat") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 112)\n  (:start . 104) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "LMP-2A") (:form . "LMP-2A") (:end . 145)\n  (:start . 139) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "eber-1") (:form . "EBER-1") (:end . 155)\n  (:start . 149) (:id . 69))\n ((:tag . "NNS") (:stem . "locus") (:form . "loci") (:end . 160)\n  (:start . 156) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 172)\n  (:start . 164) (:id . 72))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 183)\n  (:start . 173) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x774.11.1) (:span 91 94)))\n (:nscopes ((:id . :x774.11.1) (:span 91 183)))\n (:identifiers (:sid . :s774.11) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007220@unknown@formal@none@1@S@The main difference is that with thymocytes, no evidence could be found that the virus ever circularizes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "RB") (:stem . "ever") (:form . "ever") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "circularize") (:form . "circularizes") (:end . 104)\n  (:start . 92) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x774.13.1) (:span 45 56)))\n (:hscopes ((:id . :x774.13.1) (:span 45 104)))\n (:identifiers (:sid . :s774.13) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007221@unknown@formal@none@1@S@Rather, EBV remains in a linear configuration from which replicative genes are transcribed.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "configuration") (:form . "configuration")\n  (:end . 45) (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s774.14) (:did . :|7747440|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007222@unknown@formal@none@1@S@Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acid.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "b-independent") (:form . "B-independent")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 132) (:start . 128)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s775.1) (:did . :|7747447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007223@unknown@formal@none@1@S@In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "purely") (:form . "purely") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "enhancer-dependent") (:form . "enhancer-dependent")\n  (:end . 44) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . 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"HIV") (:form . "HIV") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 140)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 153)\n  (:start . 146) (:id . 69))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 158) (:start . 154)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "OKA") (:form . "OKA") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 174)\n  (:start . 165) (:id . 74))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 178) (:start . 175)\n  (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 192) (:start . 179) (:id . 76))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 200)\n  (:start . 193) (:id . 77))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 205) (:start . 201)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . 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5007225@unknown@formal@none@1@S@In both transformed and normal lymphocytes, OKA stimulation induced intense phosphorylation of the constitutively expressed Sp1 protein in the nucleus, a property of OKA not shared by TNF, phorbol ester, or PHA and interleukin 2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "OKA") (:form . "OKA") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "intense") (:form . "intense") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 91) (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 113) (:start . 99) (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 150)\n  (:start . 143) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "OKA") (:form . "OKA") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 180)\n  (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 196)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 202)\n  (:start . 197) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 210) (:start . 207)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 226)\n  (:start . 215) (:id . 79))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x775.4.1) (:span 170 173)))\n (:nscopes ((:id . :x775.4.1) (:span 170 228)))\n (:identifiers (:sid . :s775.4) (:did . :|7747447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007226@unknown@formal@none@1@S@Responsiveness of LTR constructs deleted of kappa B elements to HIV Tat expression was increased upon OKA but not TNF stimulation.@(((:tag . "NNP") (:stem . "Responsiveness") (:form . "Responsiveness")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "OKA") (:form . "OKA") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 129)\n  (:start . 118) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x775.5.1) (:span 110 113)))\n (:nscopes ((:id . :x775.5.1) (:span 110 129)))\n (:identifiers (:sid . :s775.5) (:did . :|7747447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007227@unknown@formal@none@1@S@Our results suggest that SP1 phosphorylation induced by OKA, a selective inhibitor of the serine-threonine phosphatase PP2A, facilitates the formation of a transcription complex involving general transcription factors, HIV Tat, and Sp1 proteins.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 44) (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "OKA") (:form . "OKA") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "serine-threonine") (:form . "serine-threonine")\n  (:end . 106) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . "NNP") (:stem . "PP2A") (:form . "PP2A") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "facilitate") (:form . "facilitates") (:end . 136)\n  (:start . 125) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 169) (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 187)\n  (:start . 178) (:id . 68))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 195)\n  (:start . 188) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 209) (:start . 196) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 217)\n  (:start . 210) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 226) (:start . 223)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 227) (:start . 226)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 76))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 235) (:start . 232)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 244)\n  (:start . 236) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x775.6.1) (:span 12 19)))\n (:hscopes ((:id . :x775.6.1) (:span 12 244)))\n (:identifiers (:sid . :s775.6) (:did . :|7747447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007228@unknown@formal@none@1@S@The formation of this complex would increase, independently of an in synergy with NF-kappa B, the low basal activity of the HIV LTR observed in normal T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 140)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 164)\n  (:start . 153) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s775.7) (:did . :|7747447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007230@unknown@formal@none@1@S@Type II major histocompatibility complex combined immune deficiency (type II MHC CID or bare lymphocyte syndrome) is a congenital immunodeficiency disease characterized by absent MHC class II expression.@(((:tag . "NN") (:stem . "type") (:form . "Type") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 32) (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CID") (:form . "CID") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "bare") (:form . "bare") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "congenital") (:form . "congenital") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 146) (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 168) (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 178)\n  (:start . 172) (:id . 67))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 202)\n  (:start . 192) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x776.2.1) (:span 172 178)))\n (:nscopes ((:id . :x776.2.1) (:span 172 202)))\n (:identifiers (:sid . :s776.2) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007231@unknown@formal@none@1@S@Four distinct complementation groups have been identified.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "complementation") (:form . "complementation")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s776.3) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007232@unknown@formal@none@1@S@Recently, the defective gene in group II type II MHC CID has been isolated and termed CIITA.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CID") (:form . "CID") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 65) (:start . 61)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 85) (:start . 79)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s776.4) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007233@unknown@formal@none@1@S@Here, we demonstrate that CIITA is an MHC class II gene-specific transcription activator.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "gene-specific") (:form . "gene-specific")\n  (:end . 64) (:start . 51) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s776.5) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007234@unknown@formal@none@1@S@The transcription activation function is provided by the N-terminal acidic domain (amino acids 26-137), which is experimentally exchangeable with a heterologous viral transcription-activating domain.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "26-137") (:form . "26-137") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 127) (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "exchangeable") (:form . "exchangeable") (:end . 140)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 160)\n  (:start . 148) (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 166)\n  (:start . 161) (:id . 66))\n ((:tag . "JJ") (:stem . "transcription-activating")\n  (:form . "transcription-activating") (:end . 191) (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 198)\n  (:start . 192) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s776.6) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007235@unknown@formal@none@1@S@The specificity of CIITA for three major MHC class II genes, DR, DQ and DP, is mediated by its remaining C-terminal residues (amino acids 317-1130).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DR") (:form . "DR") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DQ") (:form . "DQ") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 87)\n  (:start . 79) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 94) (:start . 91)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 104)\n  (:start . 95) (:id . 64))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 115)\n  (:start . 105) (:id . 65))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 124)\n  (:start . 116) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 137)\n  (:start . 132) (:id . 69))\n ((:tag . "CD") (:stem . "317-1130") (:form . "317-1130") (:end . 146)\n  (:start . 138) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s776.7) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007236@unknown@formal@none@1@S@The transactivation of multiple cis elements, especially S and X2, of the DR alpha proximal promoter in group II CID cells is CIITA dependent.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "X2") (:form . "X2") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DR") (:form . "DR") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CID") (:form . "CID") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 131)\n  (:start . 126) (:id . 66))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s776.8) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007237@unknown@formal@none@1@S@Since CIITA overexpression in normal cells did not increase class II expression, we propose that initiation of CIITA expression serves as the on-off switch, while availability of downstream interactor(s) limits transcription.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "on-off") (:form . "on-off") (:end . 148)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 175)\n  (:start . 163) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 189)\n  (:start . 179) (:id . 71))\n ((:tag . "JJ") (:stem . "interactor(s)") (:form . "interactor(s)")\n  (:end . 203) (:start . 190) (:id . 72))\n ((:tag . "VBZ") (:stem . "limit") (:form . "limits") (:end . 210)\n  (:start . 204) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 224) (:start . 211) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x776.9.1) (:span 84 91)))\n (:ncues ((:id . :x776.9.2) (:span 47 50)))\n (:hscopes ((:id . :x776.9.1) (:span 84 224)))\n (:nscopes ((:id . :x776.9.2) (:span 47 79)))\n (:identifiers (:sid . :s776.9) (:did . :|7749985|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007238@unknown@formal@none@1@S@Identification of two novel regulatory elements within the 5'-untranslated region of the human A gamma-globin gene.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 74) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 109)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s777.1) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007240@unknown@formal@none@1@S@We have now demonstrated that a second SSE-like element in the 5'-untranslated region of the gamma-gene also contributes to this competitive silencing of the beta-gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "sse-like") (:form . "SSE-like") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 78) (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gamma-gene") (:form . "gamma-gene") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "silencing") (:form . "silencing") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "beta-gene") (:form . "beta-gene") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s777.3) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007241@unknown@formal@none@1@S@Utilizing transient transfection assays in the fetal erythroid cell line, K562, we have shown that the core enhancer of hypersensitivity site 2 can preferentially interact with the proximal gamma-promoter in the absence of the SSE, completely silencing a linked beta-promoter.@(((:tag . "VBG") (:stem . "utilize") (:form . "Utilizing") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 32)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 39)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hypersensitivity") (:form . "hypersensitivity")\n  (:end . 136) (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 162) (:start . 148) (:id . 67))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 176) (:start . 172)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "gamma-promoter") (:form . "gamma-promoter")\n  (:end . 204) (:start . 190) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 219)\n  (:start . 212) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 77))\n ((:tag . "NN") (:stem . "sse") (:form . "SSE") (:end . 230) (:start . 227)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 231) (:start . 230)\n  (:id . 79))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 242)\n  (:start . 232) (:id . 80))\n ((:tag . "VBG") (:stem . "silence") (:form . "silencing") (:end . 252)\n  (:start . 243) (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 254) (:start . 253)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 261)\n  (:start . 255) (:id . 83))\n ((:tag . "NN") (:stem . "beta-promoter") (:form . "beta-promoter")\n  (:end . 275) (:start . 262) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x777.4.1) (:span 212 219)))\n (:nscopes ((:id . :x777.4.1) (:span 212 230)))\n (:identifiers (:sid . :s777.4) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007242@unknown@formal@none@1@S@Mutation of a 20-base pair sequence of the gamma-gene 5'-untranslated region (UTR) led to derepression of beta-promoter activity.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "20-base") (:form . "20-base") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "gamma-gene") (:form . "gamma-gene") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 69) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "UTR") (:form . "UTR") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "derepression") (:form . "derepression") (:end . 102)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "beta-promoter") (:form . "beta-promoter")\n  (:end . 119) (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s777.5) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007243@unknown@formal@none@1@S@A marked activation of gamma-promoter activity was also observed with this mutation, suggesting the presence of a repressor.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gamma-promoter") (:form . "gamma-promoter")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x777.6.1) (:span 85 95)))\n (:hscopes ((:id . :x777.6.1) (:span 85 123)))\n (:identifiers (:sid . :s777.6) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007244@unknown@formal@none@1@S@Fine mutagenesis dissected these activities to different regions of the 5'-UTR.@(((:tag . "JJ") (:stem . "fine") (:form . "Fine") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "dissect") (:form . "dissected") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "5'-utr") (:form . "5'-UTR") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s777.7) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007245@unknown@formal@none@1@S@The stage selector activity was localized to a region centered on nucleotides +13 to +15.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "selector") (:form . "selector") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "CD") (:stem . "+13") (:form . "+13") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "+15") (:form . "+15") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s777.8) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007246@unknown@formal@none@1@S@Electromobility shift assays utilizing this sequence demonstrated binding of a fetal and erythroid-specific protein.@(((:tag . "NN") (:stem . "electromobility") (:form . "Electromobility")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 21) (:start . 16)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 28)\n  (:start . 22) (:id . 44))\n ((:tag . "VBG") (:stem . "utilize") (:form . "utilizing") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 65)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 107) (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s777.9) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007247@unknown@formal@none@1@S@The repressor activity of the 5'-UTR was localized to tandem GATA-like sites, which appear to bind a complex of two proteins, one of which is the erythroid transcription factor GATA-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "5'-utr") (:form . "5'-UTR") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "gata-like") (:form . "GATA-like") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 155)\n  (:start . 146) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 169) (:start . 156) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 176)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 183)\n  (:start . 177) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x777.10.1) (:span 84 90)))\n (:hscopes ((:id . :x777.10.1) (:span 78 183)))\n (:identifiers (:sid . :s777.10) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007248@unknown@formal@none@1@S@These results indicate that the 5'-UTR of the gamma-gene contains sequences that may be important for its transcriptional and developmental regulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "5'-utr") (:form . "5'-UTR") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gamma-gene") (:form . "gamma-gene") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 121) (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x777.11.1) (:span 81 84))\n  ((:id . :x777.11.2) (:span 14 27)))\n (:hscopes ((:id . :x777.11.1) (:span 81 150))\n  ((:id . :x777.11.2) (:span 14 150)))\n (:identifiers (:sid . :s777.11) (:did . :|7759548|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007250@unknown@formal@none@1@S@The inert quality of MRL-Ipr/Ipr (Ipr) peripheral CD4-CD8- (CD4-8-) T cells manifests primarily as an inability to proliferate or produce IL-2 in response to TCR or mitogenic stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inert") (:form . "inert") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MRL-Ipr/Ipr") (:form . "MRL-Ipr/Ipr") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "CD4-CD8-") (:stem . "cd4-cd8-") (:form . "CD4-CD8-") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd4-8-") (:form . "CD4-8-") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "manifest") (:form . "manifests") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 111)\n  (:start . 102) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "VB") (:stem . "proliferate") (:form . "proliferate") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 174)\n  (:start . 165) (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 186)\n  (:start . 175) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s778.2) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007251@unknown@formal@none@1@S@Yet these same cells do initiate early TCR-mediated signaling events, such as generation of inositol phosphates and increased intracellular calcium.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "phosphate") (:form . "phosphates") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s778.3) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007252@unknown@formal@none@1@S@They also display constitutively high levels of p59fyn and CD3 zeta tyrosine phosphorylation.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 92) (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s778.4) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007253@unknown@formal@none@1@S@The generation of second messengers in T cells normally leads to downstream signaling that results in transcriptional activation of the IL-2 gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 117) (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s778.5) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007254@unknown@formal@none@1@S@We, therefore, compared the activation state of the IL-2 gene promoter region in freshly isolated and stimulated Ipr CD4-8- T cells with that of normal T lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 13)\n  (:start . 4) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd4-8-") (:form . "CD4-8-") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 165)\n  (:start . 154) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s778.6) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007255@unknown@formal@none@1@S@Levels of the octamer, NF-kappa B (p50-p65 heterodimer), and AP-1 transcriptional factors are constitutively elevated in freshly isolated Ipr CD4-8- T cells, consistent with the activated phenotype of these cells.@(((:tag . "NNS") (:stem . "level") (:form . "Levels") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 65) (:start . 61)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 81) (:start . 66) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 108) (:start . 94) (:id . 59))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd4-8-") (:form . "CD4-8-") (:end . 148)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 187)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 206)\n  (:start . 201) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s778.7) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007256@unknown@formal@none@1@S@Upon stimulation with mitogens, formation of the transactivating complex, nuclear factor of activated T cells (NF-AT), occurs with normal kinetics in Ipr CD4-8- T cells.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 137)\n  (:start . 131) (:id . 65))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CD4-8-") (:form . "CD4-8-") (:end . 160)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s778.8) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007257@unknown@formal@none@1@S@Yet, the levels of the activating NF-AT complex never reach those observed in similarly stimulated normal T cells.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 33)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "RB") (:stem . "never") (:form . "never") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "reach") (:form . "reach") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s778.9) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007258@unknown@formal@none@1@S@Furthermore, nuclear extracts from Ipr CD4-8- T cells display high levels of a novel specific binding activity at the NF-AT site, which is present at much lower levels in freshly isolated normal T lymphocytes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD4-8-") (:form . "CD4-8-") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 160) (:start . 155)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 167)\n  (:start . 161) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 72))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 178)\n  (:start . 171) (:id . 73))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 187)\n  (:start . 179) (:id . 74))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 194)\n  (:start . 188) (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 196) (:start . 195)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 208)\n  (:start . 197) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s778.10) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007260@unknown@formal@none@1@S@These two abnormalities at the NF-AT site provide a potential mechanism to account for the defect in IL-2 production from Ipr CD4-8- T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 23)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ipr") (:form . "Ipr") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD4-8-") (:form . "CD4-8-") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x778.12.1) (:span 52 61)))\n (:hscopes ((:id . :x778.12.1) (:span 52 140)))\n (:identifiers (:sid . :s778.12) (:did . :|7759875|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007261@unknown@formal@none@1@S@GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells.@(((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s779.1) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007262@unknown@formal@none@1@S@Antigen complexed with major histocompatibility complex class I or II molecules on the surface of antigen presenting cells interacts with the T cell receptor (TCR) on the surface of T cells and initiates an activation cascade.@(((:tag . "NN") (:stem . "antigen") (:form . "Antigen") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "complexe") (:form . "complexed") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 47) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 55)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 61) (:start . 56)\n  (:id . 48))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "presenting") (:form . "presenting") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 75))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 203)\n  (:start . 194) (:id . 76))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 206) (:start . 204)\n  (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 217)\n  (:start . 207) (:id . 78))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 225)\n  (:start . 218) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s779.2) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007263@unknown@formal@none@1@S@So called costimulatory signals, mediated by other cell surface interactions or soluble cytokines produced by antigen presenting cells, are also required for complete T cell activation.@(((:tag . "RB") (:stem . "so") (:form . "So") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 76)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "presenting") (:form . "presenting") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 184)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s779.3) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007264@unknown@formal@none@1@S@High levels of cytokine gene expression in T cells also required both TCR and costimulatory signals.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s779.4) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007265@unknown@formal@none@1@S@The granulocyte-macrophage colony-stimulating factor requires sequences in the promoter as well as a powerful enhancer located 3kb upstream to respond to TCR-like signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 26) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 45) (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 45))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 61)\n  (:start . 53) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 71)\n  (:start . 62) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 87)\n  (:start . 79) (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 95) (:start . 91)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 118)\n  (:start . 110) (:id . 56))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 126)\n  (:start . 119) (:id . 57))\n ((:tag . "JJ") (:stem . "3kb") (:form . "3kb") (:end . 130) (:start . 127)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 139)\n  (:start . 131) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 60))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 150)\n  (:start . 143) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tcr-like") (:form . "TCR-like") (:end . 162)\n  (:start . 154) (:id . 63))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 170)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s779.5) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007266@unknown@formal@none@1@S@These promoter and enhancer regions are mainly activated by the transcription factor nuclear factor of activated T cells (NFAT).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s779.6) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007267@unknown@formal@none@1@S@The activation of NFAT by TCR signals has been well described for interleukin-2 (IL-2) and IL-4 gene transcription in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s779.7) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007268@unknown@formal@none@1@S@Costimulatory signals, such as activation of the CD28 cell surface molecule on T cells, lead to activation through a distinct region of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter.@(((:tag . "JJ") (:stem . "costimulatory") (:form . "Costimulatory")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 162) (:start . 140) (:id . 67))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 181) (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 196)\n  (:start . 190) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 206)\n  (:start . 198) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s779.8) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007270@unknown@formal@none@1@S@Human T leukemia virus type 1 (HTLV-1) infects T cells and can lead to increase GM-CSF expression.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "infect") (:form . "infects") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 67) (:start . 63)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 57))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 79)\n  (:start . 71) (:id . 58))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 86)\n  (:start . 80) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s779.10) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007271@unknown@formal@none@1@S@We have found that the HTLV-1 transactivator protein, tax, acts as a costimulatory signal for GM-CSF and IL-2 gene transcription, in that it can cooperate with TCR signals to mediate high level gene expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 82) (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "VB") (:stem . "cooperate") (:form . "cooperate") (:end . 154)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 163) (:start . 160)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 171)\n  (:start . 164) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 73))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 182)\n  (:start . 175) (:id . 74))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 193)\n  (:start . 188) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 198) (:start . 194)\n  (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 209)\n  (:start . 199) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s779.11) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007272@unknown@formal@none@1@S@Tax activates the GM-CSF promoter through the CK-1/CD28RE region and also activates nuclear factor-kappa B binding to this region.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CK-1/CD28RE") (:form . "CK-1/CD28RE") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 104)\n  (:start . 92) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s779.12) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007273@unknown@formal@none@1@S@However, other transcription factors or coactivators of NF-kappa B are required for tax activation but these remain to be identified.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "coactivator") (:form . "coactivators") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 132)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s779.13) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007274@unknown@formal@none@1@S@The CK-1/CD28RE of GM-CSF shows a high degree of similarity to the IL-2 CD28RE and the IL-3 gene also contains a related region.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ck-1/cd28re") (:form . "CK-1/CD28RE") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd28re") (:form . "CD28RE") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s779.14) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007275@unknown@formal@none@1@S@This observation, together with the fact that both GM-CSF and IL-2 respond to TCR signals via NFAT, implies a high degree of conservation in the regulation of cytokine gene expression in T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 114) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 121)\n  (:start . 115) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 137)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 155)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 167)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x779.15.1) (:span 100 107)))\n (:hscopes ((:id . :x779.15.1) (:span 100 194)))\n (:identifiers (:sid . :s779.15) (:did . :|7759956|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007276@unknown@formal@none@1@S@MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene.@(((:tag . "NN") (:stem . "mip1") (:form . "MIP1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MNP") (:form . "MNP") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 41) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 89) (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "mip-1") (:form . "MIP-1") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s780.1) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007277@unknown@formal@none@1@S@Murine macrophage inflammatory protein 1 alpha (MIP-1 alpha) and its human equivalent (GOS19, LD78, or AT464) are members of the -C-C family of low-molecular-weight chemokines.@(((:tag . "JJ") (:stem . "murine") (:form . "Murine") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 40) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mip-1") (:form . "MIP-1") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "equivalent") (:form . "equivalent") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GOS19") (:form . "GOS19") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LD78") (:form . "LD78") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "AT464") (:form . "AT464") (:end . 108)\n  (:start . 103) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 121)\n  (:start . 114) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "-C-C") (:form . "-C-C") (:end . 133) (:start . 129)\n  (:id . 68))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 140)\n  (:start . 134) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "low-molecular-weight")\n  (:form . "low-molecular-weight") (:end . 164) (:start . 144) (:id . 71))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 175)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s780.2) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007278@unknown@formal@none@1@S@Secreted from activated T cells and macrophages, bone marrow-derived MIP-1 alpha/GOS19 inhibits primitive hematopoietic stem cells and appears to be involved in the homeostatic control of stem cell proliferation.@(((:tag . "VBN") (:stem . "secrete") (:form . "Secreted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "marrow-derived") (:form . "marrow-derived")\n  (:end . 68) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "mip-1") (:form . "MIP-1") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha/gos19") (:form . "alpha/GOS19") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 105)\n  (:start . 96) (:id . 55))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 119) (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 124) (:start . 120)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 142)\n  (:start . 135) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "homeostatic") (:form . "homeostatic") (:end . 176)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 184)\n  (:start . 177) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 68))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 192) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 197) (:start . 193)\n  (:id . 70))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 211) (:start . 198) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x780.3.1) (:span 135 142)))\n (:hscopes ((:id . :x780.3.1) (:span 135 211)))\n (:identifiers (:sid . :s780.3) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007280@unknown@formal@none@1@S@Therefore, it is important to understand the mechanisms which control the expression of MIP-1 alpha/GOS19.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MIP-1") (:form . "MIP-1") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha/gos19") (:form . "alpha/GOS19") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s780.5) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007281@unknown@formal@none@1@S@Previous work has shown that in Jurkat T cells, a set of widely expressed transcription factors (the ICK-1 family) affect the GOS19 promoter.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 63)\n  (:start . 57) (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 73)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ick-1") (:form . "ICK-1") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 121)\n  (:start . 115) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gos19") (:form . "GOS19") (:end . 131)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 140)\n  (:start . 132) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s780.6) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007282@unknown@formal@none@1@S@One member, ICK-1A, behaves as a strong negative regulator.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ICK-1A") (:form . "ICK-1A") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "behave") (:form . "behaves") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 48)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s780.7) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007283@unknown@formal@none@1@S@In this communication, we provide evidence that the pathway of induction in the macrophage cell line U937 is different from that in Jurkat cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "communication") (:form . "communication")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s780.8) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007284@unknown@formal@none@1@S@Furthermore, we show that the ICK-1 binding site does not confer negative regulation in U937 cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ick-1") (:form . "ICK-1") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x780.9.1) (:span 54 57)))\n (:nscopes ((:id . :x780.9.1) (:span 54 98)))\n (:identifiers (:sid . :s780.9) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007285@unknown@formal@none@1@S@We provide evidence for an additional binding site, the MIP-1 alpha nuclear protein (MNP) site, which overlaps the ICK-1 site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mip-1") (:form . "MIP-1") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MNP") (:form . "MNP") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 61))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 110)\n  (:start . 102) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ick-1") (:form . "ICK-1") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s780.10) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007286@unknown@formal@none@1@S@Interaction of nuclear extracts from various cell lines and tissue with the MNP site leads to the formation of fast-migrating protein-DNA complexes with similar but distinct electrophoretic mobilities.@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MNP") (:form . "MNP") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "fast-migrating") (:form . "fast-migrating")\n  (:end . 125) (:start . 111) (:id . 61))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 137)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 189) (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "mobility") (:form . "mobilities") (:end . 200)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s780.11) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007287@unknown@formal@none@1@S@A mutation of the MNP site which does not abrogate ICK-1 binding inactivates the GOS19.1 promoter in U937 cells and reduces its activity by fourfold in Jurkat cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MNP") (:form . "MNP") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VB") (:stem . "abrogate") (:form . "abrogate") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "ick-1") (:form . "ICK-1") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "VBZ") (:stem . "inactivate") (:form . "inactivates") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gos19.1") (:form . "GOS19.1") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "RB") (:stem . "fourfold") (:form . "fourfold") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x780.12.1) (:span 38 41)))\n (:nscopes ((:id . :x780.12.1) (:span 38 64)))\n (:identifiers (:sid . :s780.12) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007288@unknown@formal@none@1@S@We propose that the MNP protein(s) binding at the MNP site constitutes a novel transcription factor(s) expressed in hematopoietic cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MNP") (:form . "MNP") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "protein(s)") (:form . "protein(s)") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MNP") (:form . "MNP") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "constitute") (:form . "constitutes") (:end . 70)\n  (:start . 59) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . "NNS") (:stem . "factor(s)") (:form . "factor(s)") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 129) (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x780.13.1) (:span 3 10)))\n (:hscopes ((:id . :x780.13.1) (:span 3 135)))\n (:identifiers (:sid . :s780.13) (:did . :|7760807|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007290@unknown@formal@none@1@S@The present studies have examined the effects of pokeweed mitogen (PWM) on the induction of early growth response-1 gene (EGR-1) in normal human B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pokeweed") (:form . "pokeweed") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "response-1") (:form . "response-1") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 138)\n  (:start . 132) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s781.2) (:did . :|7769834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007291@unknown@formal@none@1@S@PWM regulates EGR-1 gene expression by both transcriptional and post-transcriptional mechanisms.@(((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 59) (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 84) (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 95)\n  (:start . 85) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s781.3) (:did . :|7769834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007292@unknown@formal@none@1@S@Transient transfection assays with EGR-1 promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene demonstrated that PWM induced EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 29)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 66) (:start . 60)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 89) (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 107) (:start . 90) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 112) (:start . 109)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 131)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 148)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 154)\n  (:start . 149) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "confer") (:form . "conferred") (:end . 181)\n  (:start . 172) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 184) (:start . 182)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CArG") (:form . "CArG") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 199)\n  (:start . 194) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 202) (:start . 201)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "C[AT]6GG") (:form . "C[AT]6GG") (:end . 211)\n  (:start . 203) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 234)\n  (:start . 226) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s781.4) (:did . :|7769834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007293@unknown@formal@none@1@S@The results further demonstrated the activation of S6 kinase (pp90rsk), evidenced by phosphorylation of S6 and serum response factor (SRF) peptides, in PWM treated B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "S6") (:form . "S6") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pp90rsk") (:form . "pp90rsk") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 100) (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "S6") (:form . "S6") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 155) (:start . 152)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "treated") (:form . "treated") (:end . 163)\n  (:start . 156) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s781.5) (:did . :|7769834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007294@unknown@formal@none@1@S@Taken together, these findings suggest that PWM is able to initiate an intracytoplasmic signalling cascade and EGR-1 induction in normal human B cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWM") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intracytoplasmic") (:form . "intracytoplasmic")\n  (:end . 87) (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x781.6.1) (:span 31 38)))\n (:hscopes ((:id . :x781.6.1) (:span 31 150)))\n (:identifiers (:sid . :s781.6) (:did . :|7769834|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007295@unknown@formal@none@1@S@Modulation of transcription factor NF kappa B activity by intracellular glutathione levels and by variations of the extracellular cysteine supply.@(((:tag . "NN") (:stem . "modulation") (:form . "Modulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "variation") (:form . "variations") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 129) (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "supply") (:form . "supply") (:end . 145)\n  (:start . 139) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s782.1) (:did . :|7781927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007296@unknown@formal@none@1@S@HIV-infected individuals and SIV-infected rhesus macaques have, on the average, decreased plasma cysteine and cystine concentrations and decreased intracellular glutathione levels.@(((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "siv-infected") (:form . "SIV-infected") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "rhesus") (:form . "rhesus") (:end . 48)\n  (:start . 42) (:id . 46))\n ((:tag . "NNS") (:stem . "macaque") (:form . "macaques") (:end . 57)\n  (:start . 49) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 62) (:start . 58)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cystine") (:form . "cystine") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 132) (:start . 118) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 146)\n  (:start . 137) (:id . 61))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 160) (:start . 147) (:id . 62))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 172)\n  (:start . 161) (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 179)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s782.2) (:did . :|7781927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007297@unknown@formal@none@1@S@We now show that a depletion of intracellular glutathione in a human T cell line (Molt-4) inhibits the activation and nuclear translocation of the transcription factor NF kappa B, whereas incubation with increasing extracellular concentrations of cysteine inhibits the DNA-binding and transactivating activity of NF kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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5007298@unknown@formal@none@1@S@Because inhibition of DNA-binding activity is associated with increasing intracellular glutathione disulfide levels and GSSG can be shown to inhibit the DNA-binding activity directly in cell-free systems, our studies suggest that GSSG is a physiologically relevant inhibitor in intact cells also.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 86) (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 98)\n  (:start . 87) (:id . 52))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 108)\n  (:start . 99) (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 115)\n  (:start . 109) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 124) (:start . 120)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 128) (:start . 125)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 131) (:start . 129)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 137)\n  (:start . 132) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 148)\n  (:start . 141) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 164)\n  (:start . 153) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 173)\n  (:start . 165) (:id . 64))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 195)\n  (:start . 186) (:id . 67))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 203)\n  (:start . 196) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 208) (:start . 205)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 216)\n  (:start . 209) (:id . 71))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 224)\n  (:start . 217) (:id . 72))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 229) (:start . 225)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 234) (:start . 230)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 237) (:start . 235)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 239) (:start . 238)\n  (:id . 76))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 255) (:start . 240) (:id . 77))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 264)\n  (:start . 256) (:id . 78))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 274)\n  (:start . 265) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 277) (:start . 275)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 284)\n  (:start . 278) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 290)\n  (:start . 285) (:id . 82))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 295) (:start . 291)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x782.4.1) (:span 217 224)))\n (:hscopes ((:id . :x782.4.1) (:span 217 295)))\n (:identifiers (:sid . :s782.4) (:did . :|7781927|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007300@unknown@formal@none@1@S@Expression of Ah receptor (TCDD receptor) during human monocytic differentiation.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ah") (:form . "Ah") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 80) (:start . 65) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s783.1) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007301@unknown@formal@none@1@S@We have previously found a high expression of human Ah receptor (TCDD receptor) mRNA in peripheral blood cells of individuals.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ah") (:form . "Ah") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TCDD") (:form . "TCDD") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 125)\n  (:start . 114) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s783.2) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007302@unknown@formal@none@1@S@In this paper, the expression of this gene in blood cells was first investigated in fractions of nucleated cells, revealing predominant expression of the Ah receptor gene in the monocyte fraction.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 67) (:start . 62)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 80)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nucleated") (:form . "nucleated") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "reveal") (:form . "revealing") (:end . 123)\n  (:start . 114) (:id . 63))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ah") (:form . "Ah") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 165)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 186)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 195)\n  (:start . 187) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s783.3) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007303@unknown@formal@none@1@S@Then the expression levels of AhR mRNA in various hematopoietic cell lines were examined together with those of Arnt and P450IA1.@(((:tag . "RB") (:stem . "then") (:form . "Then") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Arnt") (:form . "Arnt") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "P450IA1") (:form . "P450IA1") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s783.4) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007304@unknown@formal@none@1@S@AhR was expressed at high levels in monocytoid U937, THP1, and HEL/S cells, and at moderate levels in promyelocytic HL60 cells and erythroblastic HEL cells.@(((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "THP1") (:form . "THP1") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HEL/S") (:form . "HEL/S") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "moderate") (:form . "moderate") (:end . 91)\n  (:start . 83) (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 98)\n  (:start . 92) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 115) (:start . 102) (:id . 63))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "erythroblastic") (:form . "erythroblastic")\n  (:end . 145) (:start . 131) (:id . 67))\n ((:tag . "NN") (:stem . "hel") (:form . "HEL") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s783.5) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007305@unknown@formal@none@1@S@However, it was not detected in lymphoid cells MOLT4 (T cell) and BALL1 (B cell), nor in K562 erythroblasts.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "molt4") (:form . "MOLT4") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "BALL1") (:form . "BALL1") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 79) (:start . 75)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 62))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 85) (:start . 82)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 64))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 93) (:start . 89)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 107) (:start . 94) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x783.6.1) (:span 16 19 82 85)))\n (:nscopes ((:id . :x783.6.1) (:span 9 107)))\n (:identifiers (:sid . :s783.6) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007306@unknown@formal@none@1@S@Furthermore, a specific induction of AhR during monocytic differentiation was investigated in HL60 and HEL cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ahr") (:form . "AhR") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 90)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HEL") (:form . "HEL") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s783.7) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007307@unknown@formal@none@1@S@HL60 cells were induced to differentiate toward monocytes-macrophages by incubation with phorbol ester, showing a 5- to 2-fold increase of AhR mRNA.@(((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "monocytes-macrophage")\n  (:form . "monocytes-macrophages") (:end . 69) (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "CD") (:stem . "5-") (:form . "5-") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "2-fold") (:form . "2-fold") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s783.8) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007308@unknown@formal@none@1@S@The incubation with transforming growth factor beta 1 and 1 alpha,25-dihydroxyvitamin D3 resulted in a 5- to 7-fold increase of AhR mRNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha,25-dihydroxyvitamin")\n  (:form . "alpha,25-dihydroxyvitamin") (:end . 85) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "CD") (:stem . "5-") (:form . "5-") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "7-fold") (:form . "7-fold") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s783.9) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007310@unknown@formal@none@1@S@Treatment of the differentiated HL60 cells with 3-methylcholanthrene, a ligand of AhR, induced the expression of the P450IA1 gene.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "3-methylcholanthrene")\n  (:form . "3-methylcholanthrene") (:end . 68) (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p450ia1") (:form . "P450IA1") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s783.11) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007311@unknown@formal@none@1@S@These results indicated that expression of AhR mRNA was significantly induced during monocytic differentiation and that the differentiated cells were responsive to xenobiotics.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 69) (:start . 56) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 110) (:start . 95) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 138) (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 149) (:start . 145)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 160)\n  (:start . 150) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "xenobiotic") (:form . "xenobiotics") (:end . 175)\n  (:start . 164) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x783.12.1) (:span 14 28)))\n (:hscopes ((:id . :x783.12.1) (:span 14 175)))\n (:identifiers (:sid . :s783.12) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007312@unknown@formal@none@1@S@Our results suggest that AhR may play an important role in the function of monocytes and also in the eventual activation of environmental carcinogens.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AhR") (:form . "AhR") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "eventual") (:form . "eventual") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "environmental") (:form . "environmental")\n  (:end . 137) (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "carcinogen") (:form . "carcinogens") (:end . 149)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x783.13.1) (:span 29 32))\n  ((:id . :x783.13.2) (:span 12 19)))\n (:hscopes ((:id . :x783.13.1) (:span 29 149))\n  ((:id . :x783.13.2) (:span 12 149)))\n (:identifiers (:sid . :s783.13) (:did . :|7788861|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007313@unknown@formal@none@1@S@Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B.@(((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "Platelet-activating") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 26)\n  (:start . 20) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "auto-regulate") (:form . "auto-regulates")\n  (:end . 58) (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukocyte-type") (:form . "leukocyte-type")\n  (:end . 124) (:start . 110) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s784.1) (:did . :|7802642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007314@unknown@formal@none@1@S@The human platelet-activating factor receptor (PAFR) gene is transcribed by two distinct promoters (promoter 1 and promoter 2) to generate two transcripts (designated as PAFR transcript 1 and PAFR transcript 2), though their open reading frames are identical.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "platelet-activating")\n  (:form . "platelet-activating") (:end . 29) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PAFR") (:form . "PAFR") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 154)\n  (:start . 143) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 166)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PAFR") (:form . "PAFR") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 185)\n  (:start . 175) (:id . 72))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "pafr") (:form . "PAFR") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 207)\n  (:start . 197) (:id . 76))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 209) (:start . 208)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 79))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 218)\n  (:start . 212) (:id . 80))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 224)\n  (:start . 219) (:id . 81))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 229) (:start . 225)\n  (:id . 82))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 237)\n  (:start . 230) (:id . 83))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 244)\n  (:start . 238) (:id . 84))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 248) (:start . 245)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 258)\n  (:start . 249) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s784.2) (:did . :|7802642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007315@unknown@formal@none@1@S@By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 (leukocyte-type), but not PAFR transcript 2 (tissue-type), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the human stomach cancer cell line (JR-St cells) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "discriminate") (:form . 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"IN") (:stem . "as") (:form . "as") (:end . 200) (:start . 198)\n  (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 240) (:start . 204)\n  (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 242) (:start . 241)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 245) (:start . 242)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 246) (:start . 245)\n  (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 249) (:start . 247)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 253) (:start . 250)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 259)\n  (:start . 254) (:id . 87))\n ((:tag . "NN") (:stem . "stomach") (:form . "stomach") (:end . 267)\n  (:start . 260) (:id . 88))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 274)\n  (:start . 268) (:id . 89))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 279) (:start . 275)\n  (:id . 90))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 284) (:start . 280)\n  (:id . 91))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 286) (:start . 285)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "jr-st") (:form . "JR-St") (:end . 291)\n  (:start . 286) (:id . 93))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 297)\n  (:start . 292) (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 298) (:start . 297)\n  (:id . 95))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 304)\n  (:start . 299) (:id . 96))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 314)\n  (:start . 305) (:id . 97))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 319) (:start . 315)\n  (:id . 98))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 330)\n  (:start . 320) (:id . 99))\n ((:tag . "NN") (:stem . "pafr") (:form . "PAFR") (:end . 335) (:start . 331)\n  (:id . 100))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 346)\n  (:start . 336) (:id . 101))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 348) (:start . 347)\n  (:id . 102))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 352) (:start . 349)\n  (:id . 103))\n ((:tag . "NN") (:stem . "pafr") (:form . "PAFR") (:end . 357) (:start . 353)\n  (:id . 104))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 368)\n  (:start . 358) (:id . 105))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 370) (:start . 369)\n  (:id . 106))\n ((:tag . "RB") (:stem . "endogenously") (:form . "endogenously") (:end . 383)\n  (:start . 371) (:id . 107))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 384) (:start . 383)\n  (:id . 108)))@@@1@67@((:ncues ((:id . :x784.3.1) (:span 130 133)))\n (:nscopes ((:id . :x784.3.1) (:span 130 165)))\n (:identifiers (:sid . :s784.3) (:did . :|7802642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007316@unknown@formal@none@1@S@Functional analysis of the promoter 1 with a transient expression assay using chloramphenicol acetyltransferase (CAT) gene as a reporter showed that both PAF and TPA activated the promoter 1 but not the deleted promoter lacking the three consensus binding sites for NF-kappa B located from -571 bp to -459 bp.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . 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"VBD") (:stem . "activate") (:form . "activated") (:end . 175)\n  (:start . 166) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 188)\n  (:start . 180) (:id . 71))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 194) (:start . 191)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 210)\n  (:start . 203) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 219)\n  (:start . 211) (:id . 77))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 227)\n  (:start . 220) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 79))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 237)\n  (:start . 232) (:id . 80))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 247)\n  (:start . 238) (:id . 81))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 255)\n  (:start . 248) (:id . 82))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 261)\n  (:start . 256) (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 265) (:start . 262)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 274)\n  (:start . 266) (:id . 85))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 276) (:start . 275)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 284)\n  (:start . 277) (:id . 87))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 289) (:start . 285)\n  (:id . 88))\n ((:tag . "CD") (:stem . "-571") (:form . "-571") (:end . 294) (:start . 290)\n  (:id . 89))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 297) (:start . 295)\n  (:id . 90))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 300) (:start . 298)\n  (:id . 91))\n ((:tag . "CD") (:stem . "-459") (:form . "-459") (:end . 305) (:start . 301)\n  (:id . 92))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 308) (:start . 306)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 94)))@@@1@53@((:ncues ((:id . :x784.4.1) (:span 220 227))\n  ((:id . :x784.4.2) (:span 195 198)))\n (:nscopes ((:id . :x784.4.1) (:span 220 308))\n  ((:id . :x784.4.2) (:span 195 308)))\n (:identifiers (:sid . :s784.4) (:did . :|7802642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007317@unknown@formal@none@1@S@These findings suggest a molecular mechanism of positive regulation of PAFR gene expression by PAF through NF-kappa B, possibly by a phosphorylation reaction involving protein kinase C by PAF.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PAFR") (:form . "PAFR") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 148) (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 175)\n  (:start . 168) (:id . 67))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 182)\n  (:start . 176) (:id . 68))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x784.5.1) (:span 119 127))\n  ((:id . :x784.5.2) (:span 15 22)))\n (:hscopes ((:id . :x784.5.1) (:span 119 191))\n  ((:id . :x784.5.2) (:span 15 191)))\n (:identifiers (:sid . :s784.5) (:did . :|7802642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007318@unknown@formal@none@1@S@Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus-immortalized B-cell lines and contains an essential NF-kappa B site.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd48") (:form . "CD48") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 98)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "virus-immortalized") (:form . "virus-immortalized")\n  (:end . 117) (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 124)\n  (:start . 118) (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 156)\n  (:start . 147) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 165)\n  (:start . 157) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 167) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 172) (:start . 168)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s785.1) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007320@unknown@formal@none@1@S@Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV-positive B-lymphoblastoid cell lines.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 37) (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd48") (:form . "CD48") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "reproducibly") (:form . "reproducibly") (:end . 96)\n  (:start . 84) (:id . 58))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 127) (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ebv-positive") (:form . "EBV-positive") (:end . 157)\n  (:start . 145) (:id . 65))\n ((:tag . "JJ") (:stem . "b-lymphoblastoid") (:form . "B-lymphoblastoid")\n  (:end . 174) (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 185)\n  (:start . 180) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s785.3) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007321@unknown@formal@none@1@S@The element is not activated upon infection of established EBV-negative B-cell lines, indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "ebv-negative") (:form . "EBV-negative") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 158) (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x785.4.2) (:span 86 101)))\n (:ncues ((:id . :x785.4.1) (:span 106 111))\n  ((:id . :x785.4.3) (:span 15 18)))\n (:hscopes ((:id . :x785.4.2) (:span 86 168)))\n (:nscopes ((:id . :x785.4.1) (:span 106 168))\n  ((:id . :x785.4.3) (:span 0 84)))\n (:identifiers (:sid . :s785.4) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007322@unknown@formal@none@1@S@An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 142)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 157)\n  (:start . 150) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x785.5.1) (:span 81 84)))\n (:nscopes ((:id . :x785.5.1) (:span 81 157)))\n (:identifiers (:sid . :s785.5) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007323@unknown@formal@none@1@S@We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 (p50) is a part of this complex.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 119) (:start . 115)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 127) (:start . 123)\n  (:id . 67))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 135)\n  (:start . 128) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s785.6) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007324@unknown@formal@none@1@S@The EBV-encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element, suggesting that the latent membrane protein 1-driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ebv-encoded") (:form . "EBV-encoded") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . 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"other") (:end . 240)\n  (:start . 235) (:id . 78))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 251)\n  (:start . 241) (:id . 79))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 260)\n  (:start . 252) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 263) (:start . 261)\n  (:id . 81))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 271)\n  (:start . 264) (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 282)\n  (:start . 272) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 285) (:start . 283)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 294)\n  (:start . 286) (:id . 85))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 300)\n  (:start . 295) (:id . 86))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 303) (:start . 301)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 307) (:start . 304)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "drive") (:form . "drives") (:end . 314)\n  (:start . 308) (:id . 89))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 322)\n  (:start . 315) (:id . 90))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 324) (:start . 323)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 330)\n  (:start . 325) (:id . 92))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 335) (:start . 331)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 339) (:start . 336)\n  (:id . 94))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 344) (:start . 340)\n  (:id . 95))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 350)\n  (:start . 345) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 351) (:start . 350)\n  (:id . 97)))@@@1@56@((:hcues ((:id . :x785.7.1) (:span 134 144)))\n (:ncues ((:id . :x785.7.2) (:span 110 113)))\n (:hscopes ((:id . :x785.7.1) (:span 134 350)))\n (:nscopes ((:id . :x785.7.2) (:span 110 132)))\n (:identifiers (:sid . :s785.7) (:did . :|7815555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007325@unknown@formal@none@1@S@Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains.@(((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "chaperone") (:form . "chaperone") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 117) (:start . 101) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PAS") (:form . "PAS") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s786.1) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007326@unknown@formal@none@1@S@The intracellular dioxin receptor mediates signal transduction by dioxin and functions as a ligand-activated transcription factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 62)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 72)\n  (:start . 66) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ligand-activated") (:form . "ligand-activated")\n  (:end . 108) (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 129)\n  (:start . 123) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s786.2) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007327@unknown@formal@none@1@S@It contains a basic helix-loop-helix (bHLH) motif contiguous with a Per-Arnt-Sim (PAS) homology region.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "contiguous") (:form . "contiguous") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Per-Arnt-Sim") (:form . "Per-Arnt-Sim") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PAS") (:form . "PAS") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s786.3) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007328@unknown@formal@none@1@S@In extracts from nonstimulated cells the receptor is recovered in an inducible cytoplasmic form associated with the 90-kDa heat shock protein (hsp90), a molecular chaperone.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nonstimulated") (:form . "nonstimulated")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 90)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "90-kda") (:form . "90-kDa") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 162)\n  (:start . 153) (:id . 68))\n ((:tag . "NN") (:stem . "chaperone") (:form . "chaperone") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s786.4) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007330@unknown@formal@none@1@S@Deletion of the PAS domain of the receptor resulted in constitutive dimerization with Arnt.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PAS") (:form . "PAS") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Arnt") (:form . "Arnt") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s786.6) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007331@unknown@formal@none@1@S@In contrast, this receptor mutant showed low levels of xenobiotic response element-binding activity, indicating that the PAS domain may be important for DNA-binding affinity and/or specificity of the receptor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 40) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "xenobiotic") (:form . "xenobiotic") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 90) (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PAS") (:form . "PAS") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 164)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 180)\n  (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 192)\n  (:start . 181) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 208)\n  (:start . 200) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x786.7.1) (:span 132 135))\n  ((:id . :x786.7.2) (:span 101 116)))\n (:hscopes ((:id . :x786.7.1) (:span 132 208))\n  ((:id . :x786.7.2) (:span 101 208)))\n (:identifiers (:sid . :s786.7) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007332@unknown@formal@none@1@S@It was not possible to reconstitute dioxin receptor function with proteins expressed in wheat germ lysate.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "reconstitute") (:form . "reconstitute") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "wheat") (:form . "wheat") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "germ") (:form . "germ") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x786.8.1) (:span 11 19)))\n (:ncues ((:id . :x786.8.2) (:span 7 10)))\n (:hscopes ((:id . :x786.8.1) (:span 11 105)))\n (:nscopes ((:id . :x786.8.2) (:span 7 105)))\n (:identifiers (:sid . :s786.8) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007333@unknown@formal@none@1@S@In line with these observations, reticulocyte lysate but not wheat germ lysate promoted the association of de novo synthesized dioxin receptor with hsp90.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "wheat") (:form . "wheat") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "germ") (:form . "germ") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 126)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x786.9.1) (:span 57 60)))\n (:nscopes ((:id . :x786.9.1) (:span 57 78)))\n (:identifiers (:sid . :s786.9) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007334@unknown@formal@none@1@S@At least two distinct domains of the receptor mediated interaction with hsp90: the ligand-binding domain located within the PAS region and, surprisingly, the bHLH domain.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ligand-binding") (:form . "ligand-binding")\n  (:end . 97) (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PAS") (:form . "PAS") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "RB") (:stem . "surprisingly") (:form . "surprisingly") (:end . 152)\n  (:start . 140) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 169)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s786.10) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007335@unknown@formal@none@1@S@Whereas ligand-binding activity correlated with association with hsp90, bHLH-hsp90 interaction appeared to be important for DNA-binding activity but not for dimerization of the receptor.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "ligand-binding") (:form . "ligand-binding")\n  (:end . 22) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 42)\n  (:start . 32) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 46))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 59)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bhlh-hsp90") (:form . "bHLH-hsp90") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 94)\n  (:start . 83) (:id . 52))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 103)\n  (:start . 95) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 119)\n  (:start . 110) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 135)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 144)\n  (:start . 136) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 148) (:start . 145)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 152) (:start . 149)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 169)\n  (:start . 157) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 185)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x786.11.2) (:span 95 103)))\n (:ncues ((:id . :x786.11.1) (:span 149 152)))\n (:hscopes ((:id . :x786.11.2) (:span 72 185)))\n (:nscopes ((:id . :x786.11.1) (:span 149 185)))\n (:identifiers (:sid . :s786.11) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007336@unknown@formal@none@1@S@Several distinct roles for hsp90 in modulating dioxin receptor function are therefore likely: correct folding of the ligand-binding domain, interference with Arnt heterodimerization, and folding of a DNA-binding conformation of the bHLH domain.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "folding") (:form . "folding") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ligand-binding") (:form . "ligand-binding")\n  (:end . 131) (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 152)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Arnt") (:form . "Arnt") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "heterodimerization") (:form . "heterodimerization")\n  (:end . 181) (:start . 163) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "NN") (:stem . "folding") (:form . "folding") (:end . 194)\n  (:start . 187) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 211)\n  (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 224)\n  (:start . 212) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 236) (:start . 232)\n  (:id . 76))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 243)\n  (:start . 237) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x786.12.1) (:span 86 92)))\n (:hscopes ((:id . :x786.12.1) (:span 0 243)))\n (:identifiers (:sid . :s786.12) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007337@unknown@formal@none@1@S@Thus, the dioxin receptor system provides a complex and interesting model of the regulation of transcription factors by hsp90.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dioxin") (:form . "dioxin") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s786.13) (:did . :|7823943|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007338@unknown@formal@none@1@S@T-cell functional regions of the human IL-3 proximal promoter.@(((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s787.1) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007340@unknown@formal@none@1@S@Its expression is regulated at both the transcriptional and post-transcriptional level.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 80) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s787.3) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007341@unknown@formal@none@1@S@We have previously shown that treatment of Jurkat T cells with phytohemaglutinin (PHA) and the phorbol ester, PMA, activated transcription initiation from the IL-3 gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phytohemaglutinin") (:form . "phytohemaglutinin")\n  (:end . 80) (:start . 63) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 124)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 138) (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s787.4) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007342@unknown@formal@none@1@S@To define the regions of the gene required for transcription activation, we generated a series of reporter constructs containing different regions of the IL-3 gene 5' and 3' flanking sequences.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 182)\n  (:start . 174) (:id . 73))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 192)\n  (:start . 183) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s787.5) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007343@unknown@formal@none@1@S@Both positive and negative regulatory elements were identified in the proximal 5' flanking region of the IL-3 gene.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s787.6) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007344@unknown@formal@none@1@S@The promoter region between -173 and -60 contained the strongest activating elements.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "CD") (:stem . "-173") (:form . "-173") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-60") (:form . "-60") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "strong") (:form . "strongest") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s787.7) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007345@unknown@formal@none@1@S@The transcription factor AP-1 could bind to this positive activator region of the promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s787.8) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007346@unknown@formal@none@1@S@We also examined the function of the IL-3 CK-1/CK-2 elements that are present in many cytokine genes and found that they acted as a repressor of basal level expression when cloned upstream of a heterologous promoter but were also inducible by PMA/PHA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ck-1/ck-2") (:form . "CK-1/CK-2") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "act") (:form . "acted") (:end . 126) (:start . 121)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 150)\n  (:start . 145) (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 167)\n  (:start . 157) (:id . 70))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 179)\n  (:start . 173) (:id . 72))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 188)\n  (:start . 180) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 206)\n  (:start . 194) (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 215)\n  (:start . 207) (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 219) (:start . 216)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 224) (:start . 220)\n  (:id . 79))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 229) (:start . 225)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 239)\n  (:start . 230) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 242) (:start . 240)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "PMA/PHA") (:form . "PMA/PHA") (:end . 250)\n  (:start . 243) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s787.9) (:did . :|7826623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007347@unknown@formal@none@1@S@Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hybridoma") (:form . "hybridoma") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "7td1") (:form . "7TD1") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s788.1) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007348@unknown@formal@none@1@S@We have measured the level of junB mRNA in the B hybridoma cell line 7TD1, under interleukin-6 (IL-6) stimulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hybridoma") (:form . "hybridoma") (:end . 58)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "7td1") (:form . "7TD1") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 80) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 94) (:start . 81) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 113)\n  (:start . 102) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s788.2) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007350@unknown@formal@none@1@S@The first early-induced peak was transient and likely corresponds to the well documented typical junB mRNA, stimulated in response to numerous growth factors, including IL-6.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "early-induced") (:form . "early-induced")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x788.4.1) (:span 47 53)))\n (:hscopes ((:id . :x788.4.1) (:span 47 173)))\n (:identifiers (:sid . :s788.4) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007351@unknown@formal@none@1@S@At variance, the second peak which has never been reported previously, lasted several hours.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variance") (:form . "variance") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "RB") (:stem . "never") (:form . "never") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "last") (:form . "lasted") (:end . 77) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x788.5.1) (:span 39 44)))\n (:nscopes ((:id . :x788.5.1) (:span 29 69)))\n (:identifiers (:sid . :s788.5) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007352@unknown@formal@none@1@S@As a consequence of its effect on junB mRNA, IL-6 stimulated, in a biphasic fashion, the nuclear accumulation of the JunB protein.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 16)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 60)\n  (:start . 50) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 75)\n  (:start . 67) (:id . 57))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 83)\n  (:start . 76) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 96)\n  (:start . 89) (:id . 61))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 109)\n  (:start . 97) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 121) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s788.6) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007353@unknown@formal@none@1@S@In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 95) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "bimodal") (:form . "bimodal") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "JunB") (:form . "JunB") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "account") (:form . "accounted") (:end . 178)\n  (:start . 169) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 196)\n  (:start . 188) (:id . 74))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 208)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 76))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 216) (:start . 212)\n  (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 230) (:start . 217) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s788.7) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007354@unknown@formal@none@1@S@Furthermore, our data point to two major differences between the mechanism of control of the early and the late IL-6-induced junB transcription waves.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "point") (:form . "point") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "il-6-induced") (:form . "IL-6-induced") (:end . 124)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 143) (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "wave") (:form . "waves") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s788.8) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007355@unknown@formal@none@1@S@First, cycloheximide strongly potentiated the transcription of the second wave, whereas it failed to affect the early-induced burst.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 20) (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "potentiate") (:form . "potentiated") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "wave") (:form . "wave") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 97) (:start . 91)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "early-induced") (:form . "early-induced")\n  (:end . 125) (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x788.9.1) (:span 91 97)))\n (:nscopes ((:id . :x788.9.1) (:span 91 131)))\n (:identifiers (:sid . :s788.9) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007356@unknown@formal@none@1@S@Second, tyrphostin, a tyrosine kinase inhibitor, impaired the expression of the first but not the second junB mRNA peak.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "tyrphostin") (:form . "tyrphostin") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "impair") (:form . "impaired") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x788.10.1) (:span 90 93)))\n (:nscopes ((:id . :x788.10.1) (:span 90 119)))\n (:identifiers (:sid . :s788.10) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007357@unknown@formal@none@1@S@Conversely, genistein, another tyrosine kinase inhibitor, totally abolished the expression of the second peak of junB mRNA whereas it did not affect the expression of the first peak.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "junB") (:form . "junB") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 181) (:start . 177)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x788.11.1) (:span 138 141)))\n (:nscopes ((:id . :x788.11.1) (:span 138 181)))\n (:identifiers (:sid . :s788.11) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007358@unknown@formal@none@1@S@Altogether these data indicate that, in 7TD1 cells, IL-6 controls junB transcription in a biphasic fashion by means of two separate transduction pathways.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "7td1") (:form . "7TD1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 144)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x788.12.1) (:span 22 35)))\n (:hscopes ((:id . :x788.12.1) (:span 22 153)))\n (:identifiers (:sid . :s788.12) (:did . :|7836389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007360@unknown@formal@none@1@S@The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "TcR)/CD3") (:form . "TcR)/CD3") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 150)\n  (:start . 143) (:id . 68))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s789.2) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007361@unknown@formal@none@1@S@Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s789.3) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007362@unknown@formal@none@1@S@However, immediately after TcR/CD3 cross-linking (after approximately 1 h; immediate) binding of p50.p65 heterodimers was observed.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tcr/cd3") (:form . "TcR/CD3") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 48) (:start . 35) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50.p65") (:form . "p50.p65") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 117)\n  (:start . 105) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s789.4) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007363@unknown@formal@none@1@S@p50.c-rel heterodimers were also detected bound to this sequence at early time points (7-16 h; early), and both remained active at later time points (40 h; late) after activation.@(((:tag . "NN") (:stem . "p50.c-rel") (:form . "p50.c-rel") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "CD") (:stem . "7-16") (:form . "7-16") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 111) (:start . 107)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 120)\n  (:start . 112) (:id . 64))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 127)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "late") (:form . "later") (:end . 136)\n  (:start . 131) (:id . 67))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 141) (:start . 137)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 148)\n  (:start . 142) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 70))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 152) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 154) (:start . 153)\n  (:id . 72))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 155) (:start . 154)\n  (:id . 73))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 160) (:start . 156)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 75))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 167)\n  (:start . 162) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 178)\n  (:start . 168) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s789.5) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007364@unknown@formal@none@1@S@This regulation takes place mainly at the level of nuclear translocation of p65 and c-rel, at immediate and early time points.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s789.6) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007365@unknown@formal@none@1@S@Activation also induced c-rel and p105/p50 mRNA synthesis, but not p65 mRNA whose expression was constitutive.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p105/p50") (:form . "p105/p50") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x789.7.1) (:span 63 66)))\n (:nscopes ((:id . :x789.7.1) (:span 63 109)))\n (:identifiers (:sid . :s789.7) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007366@unknown@formal@none@1@S@Interestingly, all those early and late events, but not the immediate ones, were inhibited by a neutralizing anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 108)\n  (:start . 96) (:id . 61))\n ((:tag . "JJ") (:stem . "anti-tumor") (:form . "anti-tumor") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 164)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x789.8.1) (:span 52 55)))\n (:nscopes ((:id . :x789.8.1) (:span 52 74)))\n (:identifiers (:sid . :s789.8) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007367@unknown@formal@none@1@S@Similarly, cycloheximide prevented the p65 and c-rel translocation and consequent formation of active binding heterodimers, at early and late times.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "consequent") (:form . "consequent") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 122)\n  (:start . 110) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s789.9) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007368@unknown@formal@none@1@S@Cyclosporin A impaired not only early and late, but also immediate events; however, addition of TNF-alpha prevented all inhibition.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "impair") (:form . "impaired") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 115)\n  (:start . 106) (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 130)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s789.10) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007370@unknown@formal@none@1@S@TNF-alpha, therefore, emerges as the main factor responsible for a second phase of NF-kappa B regulation, controlling both translocation of p65 and c-rel, and new mRNA synthesis for c-rel and p105/p50.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "emerge") (:form . "emerges") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 104)\n  (:start . 94) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 136) (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 177)\n  (:start . 168) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 187)\n  (:start . 182) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p105/p50") (:form . "p105/p50") (:end . 200)\n  (:start . 192) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s789.12) (:did . :|7843230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007371@unknown@formal@none@1@S@Protein kinase C is not a downstream effector of p21ras in activated T cells.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x790.1.1) (:span 20 23)))\n (:nscopes ((:id . :x790.1.1) (:span 20 76)))\n (:identifiers (:sid . :s790.1) (:did . :|7843251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007372@unknown@formal@none@1@S@The aim of this present study was to investigate the role of protein kinase C (PKC), downstream of p21ras, in activating interleukin-2 (IL-2) gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 48)\n  (:start . 37) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 60))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 95)\n  (:start . 85) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 105)\n  (:start . 99) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 120)\n  (:start . 110) (:id . 66))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 134) (:start . 121) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 140) (:start . 136)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 157)\n  (:start . 147) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s790.2) (:did . :|7843251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007373@unknown@formal@none@1@S@It has been reported that PKC is an effector of p21ras in T cells.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s790.3) (:did . :|7843251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007374@unknown@formal@none@1@S@Data is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells.@(((:tag . "NNP") (:stem . "Data") (:form . "Data") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . 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5007375@unknown@formal@none@1@S@Reporter gene experiments demonstrated that NF-kappa B transcriptional activity is not affected by expression of activated p21ras.@(((:tag . "NN") (:stem . "reporter") (:form . "Reporter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 70) (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 129)\n  (:start . 123) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x790.5.1) (:span 83 86)))\n (:nscopes ((:id . :x790.5.1) (:span 83 129)))\n (:identifiers (:sid . :s790.5) (:did . :|7843251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007376@unknown@formal@none@1@S@The signaling pathways involving PKC activation, calcium mobilization and ras activation combine to provide the necessary components for production of IL-2 during T cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ras") (:form . "ras") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "VBP") (:stem . "combine") (:form . "combine") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 132)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s790.6) (:did . :|7843251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007377@unknown@formal@none@1@S@Association of alterations in NF-kappa B moieties with HIV type 1 proviral latency in certain monocytic cells.@(((:tag . "NNP") (:stem . "Association") (:form . "Association") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "moiety") (:form . "moieties") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s791.1) (:did . :|7848679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007378@unknown@formal@none@1@S@Human immunodeficiency virus type 1 (HIV-1) replication is controlled by a complex array of virally encoded and cellular proteins.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "array") (:form . "array") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "virally") (:form . "virally") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s791.2) (:did . :|7848679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007380@unknown@formal@none@1@S@Molecular mechanisms leading to restricted HIV-1 replication may differ between certain cell types.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 60)\n  (:start . 49) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x791.4.1) (:span 61 64)))\n (:hscopes ((:id . :x791.4.1) (:span 61 98)))\n (:identifiers (:sid . :s791.4) (:did . :|7848679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007381@unknown@formal@none@1@S@It is now demonstrated that HIV-1 proviral latency in the monocytic cell line U1, in which only extremely low levels of HIV-1 expression are detected in the baseline unstimulated state, is associated with alterations in nuclear factor-kappa B (NF-kappa B) moieties demonstrated in these cells by electrophoretic mobility shift assays (EMSAs) and in situ UV cross-linking studies.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 22)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . 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5007382@unknown@formal@none@1@S@A predominance of p50 NF-kappa B moieties and possibly p50 homodimers or closely related species, rather than the p50-p56 heterodimer of NF-kappa B that is the predominant NF-kappa B species in most T lymphocytic and monocytic cells, is demonstrated in the nuclei of U1 cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "predominance") (:form . "predominance") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "moiety") (:form . "moieties") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . 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5007383@unknown@formal@none@1@S@This pattern of NF-kappa B-related moieties differs from the latently infected T lymphocytic cell line ACH-2, and from the U937 monocytic line, the parental cell line of the U1 cellular clone.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "b-related") (:form . "B-related") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "moiety") (:form . "moieties") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 161) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 185)\n  (:start . 177) (:id . 73))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s791.7) (:did . :|7848679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007384@unknown@formal@none@1@S@As such, these data suggest that different proximal mechanisms may lead to restricted HIV-1 replication in various cell types.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x791.8.1) (:span 63 66)) ((:id . :x791.8.2) (:span 20 27)))\n (:hscopes ((:id . :x791.8.1) (:span 63 125))\n  ((:id . :x791.8.2) (:span 20 125)))\n (:identifiers (:sid . :s791.8) (:did . :|7848679|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007385@unknown@formal@none@1@S@Overexpression of protein kinase C-zeta stimulates leukemic cell differentiation.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "C-zeta") (:form . "C-zeta") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 80) (:start . 65) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s792.1) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007386@unknown@formal@none@1@S@A function for protein kinase C-zeta (PKC-zeta), a member of the phorbol ester nonresponsive atypical protein kinase C subfamily, in modulating differentiation was examined in the leukemic U937 cell.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "C-zeta") (:form . "C-zeta") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 72)\n  (:start . 65) (:id . 56))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonresponsive") (:form . "nonresponsive")\n  (:end . 92) (:start . 79) (:id . 58))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 143)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 159) (:start . 144) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 188)\n  (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 198) (:start . 194)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s792.2) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007387@unknown@formal@none@1@S@Transfected U937 cells stably overexpressing PKC-zeta displayed a longer doubling time, lower saturation density at confluency, and an increase in adherence to plastic as compared to control cells.@(((:tag . "VBN") (:stem . "transfecte") (:form . "Transfected") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 44) (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 72) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "doubling") (:form . "doubling") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "saturation") (:form . "saturation") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "confluency") (:form . "confluency") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "plastic") (:form . "plastic") (:end . 167)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 179)\n  (:start . 171) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 190)\n  (:start . 183) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s792.3) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007388@unknown@formal@none@1@S@PKC-zeta cells expressed a more differentiated phenotype as assessed by changes in morphology, surface antigen expression, and lysosomal enzyme activities and were distinct from parental U937 cells stimulated to differentiate by exposure to phorbol esters.@(((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 46) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 154)\n  (:start . 144) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 163) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 172)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 186)\n  (:start . 178) (:id . 68))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 70))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 208)\n  (:start . 198) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 72))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 225) (:start . 212) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 228) (:start . 226)\n  (:id . 74))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 237)\n  (:start . 229) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 240) (:start . 238)\n  (:id . 76))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 248)\n  (:start . 241) (:id . 77))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 255)\n  (:start . 249) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s792.4) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007390@unknown@formal@none@1@S@Thus, PKC-zeta overexpression stimulates a type of phenotypic differentiation that differs significantly from maturation occurring upon activation of other PKC subfamilies induced by phorbol ester treatment.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 29) (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 77) (:start . 62) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 104) (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 109) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 130)\n  (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 135) (:start . 131)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 155)\n  (:start . 150) (:id . 61))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 159) (:start . 156)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "subfamily") (:form . "subfamilies") (:end . 171)\n  (:start . 160) (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 179)\n  (:start . 172) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 190)\n  (:start . 183) (:id . 66))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 196)\n  (:start . 191) (:id . 67))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 206)\n  (:start . 197) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s792.6) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007391@unknown@formal@none@1@S@Increased expression of the c-jun protooncogene and an increase in AP-1 binding activity in PKC-zeta cells provides a potential mechanism for explaining the altered differentiation status of this cell.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "explain") (:form . "explaining") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 164)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 180) (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 187)\n  (:start . 181) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 195) (:start . 191)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x792.7.1) (:span 118 127)))\n (:hscopes ((:id . :x792.7.1) (:span 118 200)))\n (:identifiers (:sid . :s792.7) (:did . :|7848921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007392@unknown@formal@none@1@S@Posttranscriptional regulation of macrophage tissue factor expression by antioxidants.@(((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "Posttranscriptional") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 30)\n  (:start . 20) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 44))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 44)\n  (:start . 34) (:id . 45))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 51)\n  (:start . 45) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 58)\n  (:start . 52) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 85)\n  (:start . 73) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s793.1) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007393@unknown@formal@none@1@S@Tissue factor (TF) expression by cells of monocyte/macrophage lineage represents an important mechanism underlying the initiation of fibrin deposition at sites of extravascular inflammation.@(((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 61) (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 129)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "fibrin") (:form . "fibrin") (:end . 139)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "deposition") (:form . "deposition") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "extravascular") (:form . "extravascular")\n  (:end . 176) (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 189)\n  (:start . 177) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s793.2) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007394@unknown@formal@none@1@S@Recent evidence suggests a role for oxidant stress in the signalling pathway of various cell types by virtue of its ability to induce DNA binding of various transcription factors, including nuclear factor kappa B and AP-1.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "virtue") (:form . "virtue") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 170) (:start . 157) (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 178)\n  (:start . 171) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 189)\n  (:start . 180) (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 197)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 204)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 210)\n  (:start . 205) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 212) (:start . 211)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 221) (:start . 217)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x793.3.1) (:span 16 24)))\n (:hscopes ((:id . :x793.3.1) (:span 16 221)))\n (:identifiers (:sid . :s793.3) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007395@unknown@formal@none@1@S@The effect of antioxidant treatment on lipopolysaccharide (LPS)-induced TF expression was examined in murine peritoneal macrophages and human monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 57) (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LPS)-induced") (:form . "LPS)-induced") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "peritoneal") (:form . "peritoneal") (:end . 119)\n  (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 131)\n  (:start . 120) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s793.4) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007396@unknown@formal@none@1@S@Both pyrrolidine dithiocarbamate, an oxidant scavenger, and N-acetyl-cysteine, a precursor of the endogenous antioxidant glutathione, inhibited stimulation of macrophage procoagulant activity by LPS.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 32) (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "N-acetyl-cysteine") (:form . "N-acetyl-cysteine")\n  (:end . 77) (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 120)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 132)\n  (:start . 121) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 155)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "NN") (:stem . "procoagulant") (:form . "procoagulant") (:end . 182)\n  (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 191)\n  (:start . 183) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 194) (:start . 192)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 198) (:start . 195)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s793.5) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007397@unknown@formal@none@1@S@Northern blot analysis showed that neither of these agents reduced LPS-stimulated TF mRNA accumulation, thereby suggesting a posttranscriptional mechanism for the effect.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 81) (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 102)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 144) (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 154)\n  (:start . 145) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 169)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x793.6.1) (:span 112 122)))\n (:ncues ((:id . :x793.6.2) (:span 35 42)))\n (:hscopes ((:id . :x793.6.1) (:span 112 169)))\n (:nscopes ((:id . :x793.6.2) (:span 35 102)))\n (:identifiers (:sid . :s793.6) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007398@unknown@formal@none@1@S@Immunofluorescence studies of human monocytes using polyclonal anti-TF antibody showed that N-acetyl-cysteine treatment prevented the characteristic plasmalemmal localization of TF antigen that occurs in response to LPS.@(((:tag . "NNP") (:stem . "Immunofluorescence") (:form . "Immunofluorescence")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "JJ") (:stem . "anti-tf") (:form . "anti-TF") (:end . 70)\n  (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 86) (:start . 80)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "N-acetyl-cysteine") (:form . "N-acetyl-cysteine")\n  (:end . 109) (:start . 92) (:id . 53))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 119)\n  (:start . 110) (:id . 54))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 129)\n  (:start . 120) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 148) (:start . 134) (:id . 57))\n ((:tag . "JJ") (:stem . "plasmalemmal") (:form . "plasmalemmal") (:end . 161)\n  (:start . 149) (:id . 58))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 174)\n  (:start . 162) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 180) (:start . 178)\n  (:id . 61))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 188)\n  (:start . 181) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 193) (:start . 189)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 200)\n  (:start . 194) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 212)\n  (:start . 204) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 215) (:start . 213)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 219) (:start . 216)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s793.7) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007400@unknown@formal@none@1@S@Furthermore, these conditions did not result in an accumulation of the less mature forms of TF.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 63)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x793.9.1) (:span 34 37)))\n (:nscopes ((:id . :x793.9.1) (:span 34 94)))\n (:identifiers (:sid . :s793.9) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007401@unknown@formal@none@1@S@When considered together, these data suggest that antioxidants exert their effects by impairing translation and/or by causing degradation of newly translated protein.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 74)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "impair") (:form . "impairing") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 114)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 137)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 165)\n  (:start . 158) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x793.10.1) (:span 37 44)))\n (:hscopes ((:id . :x793.10.1) (:span 37 165)))\n (:identifiers (:sid . :s793.10) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007402@unknown@formal@none@1@S@The effect of antioxidants on tumor necrosis factor appeared to be species specific, with no effect on LPS-induced tumor necrosis factor in murine cells, but with inhibition in human monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 182)\n  (:start . 177) (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 192)\n  (:start . 183) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x793.11.2) (:span 52 60)))\n (:ncues ((:id . :x793.11.1) (:span 90 92)))\n (:hscopes ((:id . :x793.11.2) (:span 0 192)))\n (:nscopes ((:id . :x793.11.1) (:span 90 152)))\n (:identifiers (:sid . :s793.11) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007403@unknown@formal@none@1@S@The posttranscriptional effect of antioxidants on TF expression data suggests a novel mechanism whereby these agents might modulate monocyte/macrophage activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 23) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 46)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 151) (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x793.12.1) (:span 117 122))\n  ((:id . :x793.12.2) (:span 69 77)))\n (:hscopes ((:id . :x793.12.1) (:span 117 162))\n  ((:id . :x793.12.2) (:span 69 162)))\n (:identifiers (:sid . :s793.12) (:did . :|7849291|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007404@unknown@formal@none@1@S@Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "RB") (:stem . "persistently") (:form . "persistently") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 117) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s794.1) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007405@unknown@formal@none@1@S@The mechanisms regulating human immunodeficiency virus (HIV) persistence in human monocytes/macrophages are partially understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 48) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 72)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 103) (:start . 82) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 55))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 128)\n  (:start . 118) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s794.2) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007406@unknown@formal@none@1@S@Persistent HIV infection of U937 monocytic cells results in NF-kappa B activation.@(((:tag . "JJ") (:stem . "persistent") (:form . "Persistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s794.3) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007407@unknown@formal@none@1@S@Whether virus-induced NF-kappa B activation is a mechanism that favors continuous viral replication in macrophages remains unknown.@(((:tag . "IN") (:stem . "whether") (:form . "Whether") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "virus-induced") (:form . "virus-induced")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "favor") (:form . "favors") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 99)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 130)\n  (:start . 123) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x794.4.2) (:span 123 130)) ((:id . :x794.4.1) (:span 0 7)))\n (:hscopes ((:id . :x794.4.2) (:span 0 114))\n  ((:id . :x794.4.1) (:span 0 130)))\n (:identifiers (:sid . :s794.4) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007408@unknown@formal@none@1@S@To further delineate the molecular mechanisms involved in the activation of NF-kappa B in HIV-infected monocytes and macrophages, we have focused on the regulation of the I kappa B molecules.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 128)\n  (:start . 117) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 190)\n  (:start . 181) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s794.5) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007410@unknown@formal@none@1@S@In HIV-infected cells, I kappa B alpha protein levels are decreased secondary to enhanced protein degradation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s794.7) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007411@unknown@formal@none@1@S@This parallels the increased I kappa B alpha synthesis secondary to increased I kappa B alpha gene transcription, i.e., increased RNA and transcriptional activity of its promoter-enhancer.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "parallel") (:form . "parallels") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 153) (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 162)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter-enhancer") (:form . "promoter-enhancer")\n  (:end . 187) (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s794.8) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007412@unknown@formal@none@1@S@Another protein with I kappa B function, p105, is also modified in HIV-infected cells: p105 and p50 steady-state protein levels are increased as a result of increased synthesis and proteolytic processing of p105.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 79)\n  (:start . 67) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 112)\n  (:start . 100) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 153)\n  (:start . 147) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 166)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 176)\n  (:start . 167) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 192)\n  (:start . 181) (:id . 74))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 203)\n  (:start . 193) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 211) (:start . 207)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s794.9) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007413@unknown@formal@none@1@S@Transcriptional activity of p105 is also increased in infected cells and is also mediated by NF-kappa B through a specific kappa B motif.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s794.10) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007414@unknown@formal@none@1@S@These results demonstrate the existence of a triple autoregulatory loop in monocytes and macrophages involving HIV, p105 and p50, and MAD3, with the end result of persistent NF-kappa B activation and viral persistence.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "triple") (:form . "triple") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 66) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 100)\n  (:start . 89) (:id . 55))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MAD3") (:form . "MAD3") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 159)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 173)\n  (:start . 163) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 182)\n  (:start . 174) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 195)\n  (:start . 185) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 205)\n  (:start . 200) (:id . 76))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 217)\n  (:start . 206) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s794.11) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007415@unknown@formal@none@1@S@Furthermore, persistent HIV infection of monocytes and macrophages provides a useful model with which to study concomitant modifications of different I kappa B molecules.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s794.12) (:did . :|7853483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007416@unknown@formal@none@1@S@Expression and genomic configuration of GM-CSF, IL-3, M-CSF receptor (C-FMS), early growth response gene-1 (EGR-1) and M-CSF genes in primary myelodysplastic syndromes.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "configuration") (:form . "configuration")\n  (:end . 36) (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C-FMS") (:form . "C-FMS") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "gene-1") (:form . "gene-1") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 124)\n  (:start . 119) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 130)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 141)\n  (:start . 134) (:id . 68))\n ((:tag . "JJ") (:stem . "myelodysplastic") (:form . "myelodysplastic")\n  (:end . 157) (:start . 142) (:id . 69))\n ((:tag . "NNS") (:stem . "syndrome") (:form . "syndromes") (:end . 167)\n  (:start . 158) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s795.1) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007417@unknown@formal@none@1@S@Peripheral blood mononuclear cells from seventeen patients with primary myelodysplastic syndromes (MDS) in advanced stage were enriched for blasts and tested for (1) karyotype, (2) genomic configuration and (3) expression of IL-3, GM-CSF, FMS and EGR-1 genes which are all located on the long arm of chromosome 5.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "CD") (:stem . "seventeen") (:form . "seventeen") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . 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")") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 229) (:start . 225)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 237)\n  (:start . 231) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "FMS") (:form . "FMS") (:end . 242) (:start . 239)\n  (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 246) (:start . 243)\n  (:id . 87))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 252)\n  (:start . 247) (:id . 88))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 258)\n  (:start . 253) (:id . 89))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 264)\n  (:start . 259) (:id . 90))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 268) (:start . 265)\n  (:id . 91))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 272) (:start . 269)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 280)\n  (:start . 273) (:id . 93))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 283) (:start . 281)\n  (:id . 94))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 287) (:start . 284)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 292) (:start . 288)\n  (:id . 96))\n ((:tag . "NN") (:stem . "arm") (:form . "arm") (:end . 296) (:start . 293)\n  (:id . 97))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 299) (:start . 297)\n  (:id . 98))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 310)\n  (:start . 300) (:id . 99))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 312) (:start . 311)\n  (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 313) (:start . 312)\n  (:id . 101)))@@@1@60@((:identifiers (:sid . :s795.2) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007418@unknown@formal@none@1@S@The expression of the M-CSF gene, that has been recently reassigned to the short arm of chromosome 1 (lp), was also investigated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBN") (:stem . "reassign") (:form . "reassigned") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "arm") (:form . "arm") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lp") (:form . "lp") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 115) (:start . 111)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 128)\n  (:start . 116) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s795.3) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007420@unknown@formal@none@1@S@The latter issue was investigated by comparing, in 8 cases, constitutive DNA from skin fibroblasts with leukemic DNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 72)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s795.5) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007421@unknown@formal@none@1@S@Eleven of the 17 patients had abnormal karyotypes.@(((:tag . "CD") (:stem . "eleven") (:form . "Eleven") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "karyotype") (:form . "karyotypes") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s795.6) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007422@unknown@formal@none@1@S@The M-CSF gene was expressed in 6 cases and the FMS and the EGR-1 genes were expressed in 2 of the latter cases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "FMS") (:form . "FMS") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 65) (:start . 60)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 105)\n  (:start . 99) (:id . 63))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 111)\n  (:start . 106) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s795.7) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007423@unknown@formal@none@1@S@An autocrine mechanism of growth could be hypothesized only for the 2 patients whose cells expressed both the M-CSF and FMS genes.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "hypothesize") (:form . "hypothesized") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "FMS") (:form . "FMS") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x795.8.1) (:span 42 54)))\n (:hscopes ((:id . :x795.8.1) (:span 0 129)))\n (:identifiers (:sid . :s795.8) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007424@unknown@formal@none@1@S@No germline changes or rearrangements were observed in any of the genes studied.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x795.9.1) (:span 0 2)))\n (:nscopes ((:id . :x795.9.1) (:span 0 79)))\n (:identifiers (:sid . :s795.9) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007425@unknown@formal@none@1@S@Thus, deregulation of genes encoding for certain hemopoietic growth factors or receptors does not seem to represent a major mechanism of MDS progression.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "deregulation") (:form . "deregulation") (:end . 18)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VB") (:stem . "seem") (:form . "seem") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MDS") (:form . "MDS") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 152)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x795.10.2) (:span 98 102)))\n (:ncues ((:id . :x795.10.1) (:span 94 97)))\n (:hscopes ((:id . :x795.10.2) (:span 6 152)))\n (:nscopes ((:id . :x795.10.1) (:span 6 152)))\n (:identifiers (:sid . :s795.10) (:did . :|7858491|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007426@unknown@formal@none@1@S@OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.@(((:tag . "NNP") (:stem . "OBF-1") (:form . "OBF-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 30) (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 73) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 111)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 132) (:start . 117) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s796.1) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007427@unknown@formal@none@1@S@Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 87) (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lymphoid-restricted")\n  (:form . "lymphoid-restricted") (:end . 174) (:start . 155) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "JJ") (:stem . "site-mediated") (:form . "site-mediated")\n  (:end . 197) (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 212) (:start . 198) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 217) (:start . 213)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 226)\n  (:start . 218) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 235)\n  (:start . 227) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x796.2.1) (:span 39 52)))\n (:hscopes ((:id . :x796.2.1) (:span 39 235)))\n (:identifiers (:sid . :s796.2) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007428@unknown@formal@none@1@S@Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oct-binding factor 1 (OBF-1), a novel protein that specifically associates with Oct-1 and Oct-2.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cell-derived") (:form . "cell-derived") (:end . 64)\n  (:start . 52) (:id . 53))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "JJ") (:stem . "oct-binding") (:form . "Oct-binding") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "obf-1") (:form . "OBF-1") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 125)\n  (:start . 118) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 66))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 143)\n  (:start . 131) (:id . 67))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 154)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s796.3) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007430@unknown@formal@none@1@S@The OBF-1 mRNA is expressed in a highly cell-specific manner, being most abundant in B cells and essentially absent in most of the other cells or tissues tested.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "OBF-1") (:form . "OBF-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 53) (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "essentially") (:form . "essentially") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 136)\n  (:start . 131) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 145) (:start . 143)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 153)\n  (:start . 146) (:id . 69))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 160)\n  (:start . 154) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x796.5.1) (:span 109 115)))\n (:nscopes ((:id . :x796.5.1) (:span 109 160)))\n (:identifiers (:sid . :s796.5) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007431@unknown@formal@none@1@S@Furthermore, expression of OBF-1 in HeLa cells selectively stimulates the activity of a natural immunoglobulin promoter in an octamer site-dependent manner.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "obf-1") (:form . "OBF-1") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 110) (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "JJ") (:stem . "site-dependent") (:form . "site-dependent")\n  (:end . 148) (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 155)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s796.6) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007432@unknown@formal@none@1@S@Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "OBF-1") (:form . "OBF-1") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 34)\n  (:start . 24) (:id . 48))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 65) (:start . 52) (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 81) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s796.7) (:did . :|7859290|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007433@unknown@formal@none@1@S@Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.@(((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "Glucocorticoid-induced") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 32)\n  (:start . 23) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 50)\n  (:start . 42) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 115) (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s797.1) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007434@unknown@formal@none@1@S@Induction of apoptosis in lymphocytes, which may account for the therapeutic effects of glucocorticoids in various diseases including leukemia, depends on the glucocorticoid receptor.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 103) (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 133)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 173) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 182)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x797.2.1) (:span 45 48)))\n (:hscopes ((:id . :x797.2.1) (:span 45 142)))\n (:identifiers (:sid . :s797.2) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007435@unknown@formal@none@1@S@However, the events leading from the activated receptor to cell lysis are not understood.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x797.3.1) (:span 74 77)))\n (:nscopes ((:id . :x797.3.1) (:span 9 88)))\n (:identifiers (:sid . :s797.3) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007436@unknown@formal@none@1@S@A prevailing hypothesis postulates induction of so-called 'lysis genes' by the activated receptor.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "prevail") (:form . "prevailing") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "postulate") (:form . "postulates") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "'lysis") (:form . "'lysis") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x797.4.1) (:span 13 23)))\n (:hscopes ((:id . :x797.4.1) (:span 13 97)))\n (:identifiers (:sid . :s797.4) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007437@unknown@formal@none@1@S@In this study, we show that an activation-deficient glucocorticoid receptor mutant is as effective as the wild-type receptor in repression of AP-1 activity, inhibition of interleukin-2 production, inhibition of c-myc expression and induction of apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "activation-deficient")\n  (:form . "activation-deficient") (:end . 51) (:start . 31) (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 66) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 167)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 184) (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 195)\n  (:start . 185) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 207)\n  (:start . 197) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 216)\n  (:start . 211) (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 227)\n  (:start . 217) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 76))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 241)\n  (:start . 232) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 244) (:start . 242)\n  (:id . 78))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 254)\n  (:start . 245) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s797.5) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007438@unknown@formal@none@1@S@Furthermore, we show that retinoic acid can also induce apoptosis in these cells through the retinoic acid receptor, whose repressive functions but not target site specificity, are similar to those of the glucocorticoid receptor.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 163) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 175)\n  (:start . 164) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 197)\n  (:start . 192) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 219) (:start . 205) (:id . 77))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 228)\n  (:start . 220) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x797.6.1) (:span 148 151)))\n (:nscopes ((:id . :x797.6.1) (:span 148 175)))\n (:identifiers (:sid . :s797.6) (:did . :|7859735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007440@unknown@formal@none@1@S@Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Runt") (:form . "Runt") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "domain-encoding") (:form . "domain-encoding")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s798.1) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007441@unknown@formal@none@1@S@The PEBP2 alpha A and PEBP2 alpha B genes encode the DNA-binding subunit of a murine transcription factor, PEBP2, which is implicated as a T-cell-specific transcriptional regulator.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 64)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PEBP2") (:form . "PEBP2") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 133)\n  (:start . 123) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 154) (:start . 139) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 170) (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 180)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s798.2) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007442@unknown@formal@none@1@S@These two related genes share the evolutionarily conserved region encoding the Runt domain.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 48) (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "runt") (:form . "Runt") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s798.3) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007443@unknown@formal@none@1@S@PEBP2 alpha B is the murine counterpart of human AML1, which is located at the breakpoints of the 8;21 and 3;21 chromosome translocations associated with acute myeloid leukemia.@(((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "counterpart") (:form . "counterpart") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "breakpoint") (:form . "breakpoints") (:end . 90)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "CD") (:stem . "8;21") (:form . "8;21") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "CD") (:stem . "3;21") (:form . "3;21") (:end . 111) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 122)\n  (:start . 112) (:id . 64))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 137) (:start . 123) (:id . 65))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 148)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 167)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 176)\n  (:start . 168) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s798.4) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007444@unknown@formal@none@1@S@Northern (RNA) blots of various adult mouse tissues revealed that the levels of expression of both genes were most prominent in the thymus.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "prominent") (:form . "prominent") (:end . 124)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 138)\n  (:start . 132) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s798.5) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007445@unknown@formal@none@1@S@Furthermore, transcripts of PEBP2 alpha A and mouse AML1/PEBP2 alpha B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns, as well as 4-week-old adult mice, by in situ hybridization.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "aml1/pebp2") (:form . "AML1/PEBP2") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "thymus") (:form . "thymuses") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "newborn") (:form . "newborns") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 159) (:start . 155)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "4-week-old") (:form . "4-week-old") (:end . 173)\n  (:start . 163) (:id . 72))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 179)\n  (:start . 174) (:id . 73))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 184)\n  (:start . 180) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 76))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 77))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 196) (:start . 192)\n  (:id . 78))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 210) (:start . 197) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s798.6) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007446@unknown@formal@none@1@S@The expression of the genes persisted in peripheral lymph nodes of adult mice.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "persist") (:form . "persisted") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s798.7) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007447@unknown@formal@none@1@S@The transcripts were detected in all the CD4- CD8-, CD4+ CD8+, CD4+ CD8-, and CD4- CD8+ cell populations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd4-") (:form . "CD4-") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd8-") (:form . "CD8-") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD8-") (:form . "CD8-") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cd4-") (:form . "CD4-") (:end . 82) (:start . 78)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 87) (:start . 83)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 104)\n  (:start . 93) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s798.8) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007448@unknown@formal@none@1@S@The results indicated that both genes are expressed in T cells throughout their development, supporting the notion that PEBP2 is a T-cell-specific transcription factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 79)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "support") (:form . "supporting") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pebp2") (:form . "PEBP2") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 146) (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 160) (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x798.9.1) (:span 108 114))\n  ((:id . :x798.9.2) (:span 12 26)))\n (:hscopes ((:id . :x798.9.1) (:span 108 167))\n  ((:id . :x798.9.2) (:span 12 167)))\n (:identifiers (:sid . :s798.9) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007450@unknown@formal@none@1@S@The implication of mouse AML1/PEBP2 alpha B expression in hematopoietic cells other than those of T-cell lineage is discussed in relation to myeloid leukemogenesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "implication") (:form . "implication") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "aml1/pebp2") (:form . "AML1/PEBP2") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "leukemogenesis") (:form . "leukemogenesis")\n  (:end . 163) (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s798.11) (:did . :|7862157|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007451@unknown@formal@none@1@S@Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 32) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 46) (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 55)\n  (:start . 47) (:id . 46))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 67)\n  (:start . 56) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 84) (:start . 83)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 94)\n  (:start . 85) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 99) (:start . 95)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 111)\n  (:start . 103) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 124)\n  (:start . 112) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 132)\n  (:start . 125) (:id . 56))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 138)\n  (:start . 133) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 58))\n ((:tag . "CD") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 148)\n  (:start . 140) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 162)\n  (:start . 154) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 164) (:start . 163)\n  (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 171)\n  (:start . 165) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 180)\n  (:start . 172) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x799.1.1) (:span 85 94)))\n (:hscopes ((:id . :x799.1.1) (:span 85 180)))\n (:identifiers (:sid . :s799.1) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007452@unknown@formal@none@1@S@The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s799.2) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007453@unknown@formal@none@1@S@Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "CD") (:stem . "-299") (:form . "-299") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "CD") (:stem . "-228") (:form . "-228") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CArG") (:form . "CArG") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s799.3) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007454@unknown@formal@none@1@S@We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 34) (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . "CD") (:stem . "-137") (:form . "-137") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-64") (:form . "-64") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s799.4) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007455@unknown@formal@none@1@S@This element had maximal activity in lymphoid cells, paralleling the cell type specificity of Elf-1 expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "parallel") (:form . "paralleling") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s799.5) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007456@unknown@formal@none@1@S@Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s799.6) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007457@unknown@formal@none@1@S@Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells.@(((:tag . "NN") (:stem . "coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-137") (:form . "-137") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-64") (:form . "-64") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cos-7") (:form . "COS-7") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s799.7) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007458@unknown@formal@none@1@S@Elf-1 physically associated with HMG-I and with NF-kappa B p50 and c-Rel in vitro, suggesting that protein-protein interactions might functionally coordinate the actions of the upstream and downstream positive regulatory elements.@(((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HMG-I") (:form . "HMG-I") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 114) (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 146)\n  (:start . 134) (:id . 62))\n ((:tag . "VB") (:stem . "coordinate") (:form . "coordinate") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 169)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 185)\n  (:start . 177) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 200)\n  (:start . 190) (:id . 70))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 209)\n  (:start . 201) (:id . 71))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 220)\n  (:start . 210) (:id . 72))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 229)\n  (:start . 221) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x799.8.1) (:span 128 133))\n  ((:id . :x799.8.2) (:span 83 93)))\n (:hscopes ((:id . :x799.8.1) (:span 128 229))\n  ((:id . :x799.8.2) (:span 83 229)))\n (:identifiers (:sid . :s799.8) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007460@unknown@formal@none@1@S@These findings provide significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression and also have implications for other genes regulated by Elf-1 and NF-kappa B family proteins.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 72) (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 88)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 101)\n  (:start . 89) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 115)\n  (:start . 107) (:id . 55))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 134) (:start . 116) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 148)\n  (:start . 139) (:id . 58))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 154)\n  (:start . 149) (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 160)\n  (:start . 155) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 165) (:start . 161)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 176)\n  (:start . 166) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 63))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 185) (:start . 181)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 190) (:start . 186)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 203)\n  (:start . 191) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 207) (:start . 204)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 213)\n  (:start . 208) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 219)\n  (:start . 214) (:id . 69))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 229)\n  (:start . 220) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 232) (:start . 230)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 238)\n  (:start . 233) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 251)\n  (:start . 243) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 253) (:start . 252)\n  (:id . 75))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 260)\n  (:start . 254) (:id . 76))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 269)\n  (:start . 261) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s799.10) (:did . :|7862168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007461@unknown@formal@none@1@S@Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 99)\n  (:start . 88) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s800.1) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007462@unknown@formal@none@1@S@Glucocorticoids have an inhibitory effect on inflammatory and immune responses, and this may be through the modulation of transcription factor binding to DNA.@(((:tag . "NNS") (:stem . "glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x800.2.1) (:span 89 92)))\n (:hscopes ((:id . :x800.2.1) (:span 89 157)))\n (:identifiers (:sid . :s800.2) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007463@unknown@formal@none@1@S@The interaction of the transcription factors, activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . 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5007464@unknown@formal@none@1@S@TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "CD") (:stem . "200") (:form . "200") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 136)\n  (:start . 127) (:id . 68))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 141) (:start . 137)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 149)\n  (:start . 142) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 71))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 153) (:start . 151)\n  (:id . 72))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 154) (:start . 153)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 74))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 160) (:start . 156)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "60-min") (:form . "60-min") (:end . 169)\n  (:start . 163) (:id . 77))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 174) (:start . 170)\n  (:id . 78))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 181)\n  (:start . 175) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s800.4) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007465@unknown@formal@none@1@S@Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1, NF kappa B, and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "CD") (:stem . "40-50") (:form . "40-50") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 172)\n  (:start . 165) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 181) (:start . 178)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 189)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 192) (:start . 190)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 201)\n  (:start . 193) (:id . 75))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 215) (:start . 202) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 228)\n  (:start . 220) (:id . 78))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 231) (:start . 229)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 235) (:start . 232)\n  (:id . 80))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 245)\n  (:start . 236) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s800.5) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007466@unknown@formal@none@1@S@These latter effects were due to increases in the nuclear localization of GR, not to reduced amounts of the other transcription factors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GR") (:form . "GR") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x800.6.1) (:span 78 81)))\n (:nscopes ((:id . :x800.6.1) (:span 78 135)))\n (:identifiers (:sid . :s800.6) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007467@unknown@formal@none@1@S@This suggests that in these cells GR within the nucleus interacts with cytokine-stimulated transcription factors by the process of cross coupling.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gr") (:form . "GR") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytokine-stimulated")\n  (:form . "cytokine-stimulated") (:end . 90) (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cross") (:form . "cross") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "coupling") (:form . "coupling") (:end . 145)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x800.7.1) (:span 5 13)))\n (:hscopes ((:id . :x800.7.1) (:span 5 145)))\n (:identifiers (:sid . :s800.7) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007468@unknown@formal@none@1@S@This may be an important molecular site of steroid action.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x800.8.1) (:span 5 8)))\n (:hscopes ((:id . :x800.8.1) (:span 5 57)))\n (:identifiers (:sid . :s800.8) (:did . :|7864072|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007470@unknown@formal@none@1@S@To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development, a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Kruppel-related zinc finger genes from the human monoblast cell line U-937.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "complexity") (:form . "complexity") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . 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"zinc") (:end . 321) (:start . 317)\n  (:id . 88))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 328)\n  (:start . 322) (:id . 89))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 334)\n  (:start . 329) (:id . 90))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 339) (:start . 335)\n  (:id . 91))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 343) (:start . 340)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 349)\n  (:start . 344) (:id . 93))\n ((:tag . "NN") (:stem . "monoblast") (:form . "monoblast") (:end . 359)\n  (:start . 350) (:id . 94))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 364) (:start . 360)\n  (:id . 95))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 369) (:start . 365)\n  (:id . 96))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 375)\n  (:start . 370) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5007471@unknown@formal@none@1@S@By extensive nucleotide sequence and Northern blot analysis, these cDNA clones were found to originate from approximately 42 different genes (HZF 1-42) of which only 8 have previously been described.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "northern") (:form . "Northern") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "VB") (:stem . "originate") (:form . "originate") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HZF") (:form . "HZF") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1-42") (:form . "1-42") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 183)\n  (:start . 173) (:id . 72))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 188) (:start . 184)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 198)\n  (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s801.3) (:did . :|7865130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007472@unknown@formal@none@1@S@Northern blot analysis showed that a majority of these genes were expressed at comparable levels in U-937 and HeLa cells.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "U-937") (:form . "U-937") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s801.4) (:did . :|7865130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007473@unknown@formal@none@1@S@The large number of individual genes represented among the 63 clones and their apparent non-cell-type-specific expression suggest that the majority of the Kruppel-related zinc finger genes are likely to be expressed in most human tissues.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "CD") (:stem . "63") (:form . "63") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 78)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "non-cell-type-specific")\n  (:form . "non-cell-type-specific") (:end . 110) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 57))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 129)\n  (:start . 122) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "kruppel-related") (:form . "Kruppel-related")\n  (:end . 170) (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 175) (:start . 171)\n  (:id . 65))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 182)\n  (:start . 176) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 188)\n  (:start . 183) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 192) (:start . 189)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 199)\n  (:start . 193) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 202) (:start . 200)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 215)\n  (:start . 206) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 73))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 229)\n  (:start . 224) (:id . 75))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 237)\n  (:start . 230) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x801.5.1) (:span 193 199))\n  ((:id . :x801.5.2) (:span 122 129)))\n (:hscopes ((:id . :x801.5.1) (:span 135 237))\n  ((:id . :x801.5.2) (:span 122 237)))\n (:identifiers (:sid . :s801.5) (:did . :|7865130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007474@unknown@formal@none@1@S@In contrast, some of the genes displayed a restricted expression pattern, indicating that they represent potential regulators of monocyte differentiation or proliferation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 40)\n  (:start . 31) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 153) (:start . 138) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 170) (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x801.6.1) (:span 105 114))\n  ((:id . :x801.6.2) (:span 74 89)))\n (:hscopes ((:id . :x801.6.1) (:span 105 170))\n  ((:id . :x801.6.2) (:span 74 170)))\n (:identifiers (:sid . :s801.6) (:did . :|7865130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007475@unknown@formal@none@1@S@Detailed structural analysis of the first 12 cDNAs (HZF 1-10) and a partial characterization of HZF 11-42 revealed that a common feature of human Kruppel-related zinc finger proteins is the presence of tandem arrays of zinc fingers ranging in number from 3 to over 20 that are preferentially located in the carboxy-terminal regions of the proteins.@(((:tag . "JJ") (:stem . "detailed") (:form . "Detailed") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "12") (:form . 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5007476@unknown@formal@none@1@S@In addition, several novel KRAB-containing zinc finger genes and a novel conserved sequence element were identified.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "krab-containing") (:form . "KRAB-containing")\n  (:end . 42) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s801.8) (:did . :|7865130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007477@unknown@formal@none@1@S@Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.@(((:tag . "JJ") (:stem . "calcium/calmodulin-dependent")\n  (:form . "Calcium/calmodulin-dependent") (:end . 28) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 43)\n  (:start . 37) (:id . 44))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 46) (:start . 44)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "downregulate") (:form . "downregulates")\n  (:end . 60) (:start . 47) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 65) (:start . 61)\n  (:id . 47))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 77)\n  (:start . 66) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 96)\n  (:start . 90) (:id . 51))\n ((:tag . "JJ") (:stem . "c-mediated") (:form . "C-mediated") (:end . 107)\n  (:start . 97) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 116)\n  (:start . 108) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 129)\n  (:start . 121) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 148) (:start . 135) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 157)\n  (:start . 152) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s802.1) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007478@unknown@formal@none@1@S@Engagement of the T cell receptor for antigen activates phospholipase C resulting in an increase in intracellular free calcium concentration ([Ca2+]i) and activation of protein kinase C (PKC).@(((:tag . "NN") (:stem . "engagement") (:form . "Engagement") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "phospholipase") (:form . "phospholipase")\n  (:end . 69) (:start . 56) (:id . 51))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 113) (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 140) (:start . 127) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "FW") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 176)\n  (:start . 169) (:id . 69))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s802.2) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007480@unknown@formal@none@1@S@Recent studies have identified calcineurin as a key enzyme for interleukin (IL)-2 and IL-4 promoter activation.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "IL)-2") (:form . "IL)-2") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s802.4) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007481@unknown@formal@none@1@S@However, the role of CaM-K II remains unknown.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CaM-K") (:form . "CaM-K") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x802.5.1) (:span 38 45)))\n (:hscopes ((:id . :x802.5.1) (:span 9 45)))\n (:identifiers (:sid . :s802.5) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007482@unknown@formal@none@1@S@We have used mutants of these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively) to explore their relative role in cytokine gene transcription and their interactions with PKC-dependent signaling systems.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b*cam-k") (:form . "B*CaM-K") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CaM-AI") (:form . "CaM-AI") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 100)\n  (:start . 88) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 163) (:start . 150) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 186)\n  (:start . 174) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "pkc-dependent") (:form . "PKC-dependent")\n  (:end . 205) (:start . 192) (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 215)\n  (:start . 206) (:id . 74))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 223)\n  (:start . 216) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s802.6) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007483@unknown@formal@none@1@S@gamma B*CaM-K and delta CaM-AI, known to exhibit constitutive Ca(2+)-independent activity, were cotransfected (alone or in combination) in Jurkat T cells with a plasmid containing the intact IL-2 promoter driving the expression of the chloramphenicol acetyltransferase reporter gene.@(((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "b*cam-k") (:form . "B*CaM-K") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CaM-AI") (:form . "CaM-AI") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "exhibit") (:form . "exhibit") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "Ca(2+)-independent") (:form . "Ca(2+)-independent")\n  (:end . 80) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 109) (:start . 96) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 190)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 195) (:start . 191)\n  (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 204)\n  (:start . 196) (:id . 74))\n ((:tag . "VBG") (:stem . "drive") (:form . "driving") (:end . 212)\n  (:start . 205) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 227)\n  (:start . 217) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 250) (:start . 235) (:id . 80))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 268) (:start . 251) (:id . 81))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 277)\n  (:start . 269) (:id . 82))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 282) (:start . 278)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s802.7) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007484@unknown@formal@none@1@S@Cotransfection of gamma B*CaM-K with the IL-2 promoter construct downregulated its transcription in response to stimulation with ionomycin and phorbol myristate acetate (PMA).@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b*cam-k") (:form . "B*CaM-K") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "VBD") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 138)\n  (:start . 129) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 150)\n  (:start . 143) (:id . 61))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 160)\n  (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 168)\n  (:start . 161) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s802.8) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007485@unknown@formal@none@1@S@The inhibitory effect of CaM-K II on IL-2 promoter was associated with decreased transcription of its AP-1 and NF-AT transactivating pathways.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CaM-K") (:form . "CaM-K") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "transactivating") (:form . "transactivating")\n  (:end . 132) (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s802.9) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007486@unknown@formal@none@1@S@Under the same conditions, delta CaM-AI superinduced IL-2 promoter activity (approximately twofold increase).@(((:tag . "IN") (:stem . "under") (:form . "Under") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CaM-AI") (:form . "CaM-AI") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "superinduce") (:form . "superinduced") (:end . 52)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "JJ") (:stem . "twofold") (:form . "twofold") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s802.10) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007487@unknown@formal@none@1@S@When both mutants were used in combination, gamma B*CaM-K inhibited the induction of the IL-2 promoter by delta CaM-AI.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b*cam-k") (:form . "B*CaM-K") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "CaM-AI") (:form . "CaM-AI") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s802.11) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007488@unknown@formal@none@1@S@Similar results were obtained when a construct containing the IL-4 promoter also was used.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s802.12) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007490@unknown@formal@none@1@S@These results suggest that CaM-K II may exert negative influences on cytokine gene transcription in human T cells, and provide preliminary evidence for negative cross-talk with the calcineurin- and PKC- dependent signaling systems.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CaM-K") (:form . "CaM-K") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "influence") (:form . "influences") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 138)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "cross-talk") (:form . "cross-talk") (:end . 171)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 176) (:start . 172)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "calcineurin-") (:form . "calcineurin-") (:end . 193)\n  (:start . 181) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 71))\n ((:tag . "NN") (:stem . "pkc-") (:form . "PKC-") (:end . 202) (:start . 198)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 212)\n  (:start . 203) (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 222)\n  (:start . 213) (:id . 74))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 230)\n  (:start . 223) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x802.14.1) (:span 36 39))\n  ((:id . :x802.14.2) (:span 14 21)))\n (:hscopes ((:id . :x802.14.1) (:span 36 113))\n  ((:id . :x802.14.2) (:span 14 113)))\n (:identifiers (:sid . :s802.14) (:did . :|7869038|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007491@unknown@formal@none@1@S@Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.@(((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "site-specific") (:form . "site-specific")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "signal-induced") (:form . "signal-induced")\n  (:end . 71) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 87) (:start . 72) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s803.1) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007492@unknown@formal@none@1@S@I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm.@(((:tag . "NN") (:stem . "i") (:form . "I") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "retain") (:form . "retaining") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s803.2) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007493@unknown@formal@none@1@S@Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "pathogen") (:form . "pathogens") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "VBP") (:stem . "inactivate") (:form . "inactivate") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s803.3) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007494@unknown@formal@none@1@S@This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "liberate") (:form . "liberates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "translocate") (:form . "translocate") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s803.4) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007495@unknown@formal@none@1@S@Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s803.5) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007496@unknown@formal@none@1@S@When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "serine-32") (:form . "serine-32") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "serine-36") (:form . "serine-36") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "JJ") (:stem . "signal-induced") (:form . "signal-induced")\n  (:end . 109) (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 125) (:start . 110) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x803.6.1) (:span 163 166))\n  ((:id . :x803.6.2) (:span 83 86)))\n (:nscopes ((:id . :x803.6.1) (:span 146 179))\n  ((:id . :x803.6.2) (:span 83 140)))\n (:identifiers (:sid . :s803.6) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007497@unknown@formal@none@1@S@These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x803.7.1) (:span 14 21)))\n (:hscopes ((:id . :x803.7.1) (:span 14 116)))\n (:identifiers (:sid . :s803.7) (:did . :|7878466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007498@unknown@formal@none@1@S@HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 85) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s804.1) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007500@unknown@formal@none@1@S@Negative, positive, and no effects of Nef have also been reported on viral replication in cells.@(((:tag . "JJ") (:stem . "negative") (:form . "Negative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 86)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x804.3.1) (:span 24 26)))\n (:nscopes ((:id . :x804.3.1) (:span 24 41)))\n (:identifiers (:sid . :s804.3) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007501@unknown@formal@none@1@S@To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "reconcile") (:form . "reconcile") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "cd8-nef") (:form . "CD8-Nef") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s804.4) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007502@unknown@formal@none@1@S@Two opposite phenotypes were found, which depended on the intracellular localization of Nef.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "depend") (:form . "depended") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s804.5) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007503@unknown@formal@none@1@S@Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor.@(((:tag . "VBN") (:stem . "express") (:form . "Expressed") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chimera") (:form . "chimera") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s804.6) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007504@unknown@formal@none@1@S@Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "die") (:form . "died") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "nef") (:form . "Nefs") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "survive") (:form . "survived") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "VBD") (:stem . "render") (:form . "rendered") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nonfunctional") (:form . "nonfunctional")\n  (:end . 148) (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s804.7) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007505@unknown@formal@none@1@S@These mutations paralleled those in other viral strains passaged in vitro.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "parallel") (:form . "paralleled") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "VBN") (:stem . "passage") (:form . "passaged") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s804.8) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007506@unknown@formal@none@1@S@Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.@(((:tag . "RB") (:stem . "not") (:form . "Not") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "positional") (:form . "positional") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "reconcile") (:form . "reconcile") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "myristylation") (:form . "myristylation")\n  (:end . 131) (:start . 118) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "explain") (:form . "explain") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 186)\n  (:start . 177) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 202)\n  (:start . 191) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 205) (:start . 203)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 210) (:start . 206)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x804.9.1) (:span 84 91)))\n (:hscopes ((:id . :x804.9.1) (:span 84 131)))\n (:identifiers (:sid . :s804.9) (:did . :|7882168|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007507@unknown@formal@none@1@S@LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha.@(((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "target") (:form . "targeting") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s805.1) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007508@unknown@formal@none@1@S@LMP-1, an Epstein-Barr virus membrane protein expressed during latent infection, has oncogenic properties, as judged from its ability to transform B lymphocytes and rodent fibroblasts.@(((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 22)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "VB") (:stem . "transform") (:form . "transform") (:end . 146)\n  (:start . 137) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 160)\n  (:start . 149) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "rodent") (:form . "rodent") (:end . 171)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 183)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s805.2) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007510@unknown@formal@none@1@S@The mechanisms by which LMP-1 upregulates these proteins is unknown, but it is plausible that LMP-1 modifies signal transduction pathways that result in the activation of one or more transcription factors that ultimately regulate transcription of oncogenic genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "upregulate") (:form . "upregulates") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "plausible") (:form . "plausible") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "modify") (:form . "modifies") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 128)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 167)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 182) (:start . 178)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 196) (:start . 183) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 204)\n  (:start . 197) (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 220)\n  (:start . 210) (:id . 75))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 229)\n  (:start . 221) (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 243) (:start . 230) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 256)\n  (:start . 247) (:id . 79))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 262)\n  (:start . 257) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x805.4.1) (:span 79 88)) ((:id . :x805.4.2) (:span 60 67)))\n (:hscopes ((:id . :x805.4.1) (:span 79 262))\n  ((:id . :x805.4.2) (:span 0 67)))\n (:identifiers (:sid . :s805.4) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007511@unknown@formal@none@1@S@NF-kappa B, a transcription factor controlling the expression of genes involved in cell activation and growth control, has been shown to be activated by LMP-1.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 149)\n  (:start . 140) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s805.5) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007512@unknown@formal@none@1@S@The mechanism(s) regulating this activation remains unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 49)))@@@1@8@((:hcues ((:id . :x805.6.1) (:span 52 59)))\n (:hscopes ((:id . :x805.6.1) (:span 0 59)))\n (:identifiers (:sid . :s805.6) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007513@unknown@formal@none@1@S@Our data indicate that increased NF-kappa B DNA binding and functional activity are present in B-lymphoid cells stably or transiently expressing LMP-1.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "b-lymphoid") (:form . "B-lymphoid") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 133)\n  (:start . 122) (:id . 61))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x805.7.1) (:span 9 22)))\n (:hscopes ((:id . :x805.7.1) (:span 9 150)))\n (:identifiers (:sid . :s805.7) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007514@unknown@formal@none@1@S@I kappa B alpha is selectively modified in LMP-1-expressing B cells.@(((:tag . "NN") (:stem . "i") (:form . "I") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lmp-1-expressing") (:form . "LMP-1-expressing")\n  (:end . 59) (:start . 43) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s805.8) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007515@unknown@formal@none@1@S@A phosphorylated form of I kappa B alpha and increased protein turnover-degradation correlate with increased NF-kappa B nuclear translocation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "phosphorylated") (:form . "phosphorylated")\n  (:end . 16) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "turnover-degradation")\n  (:form . "turnover-degradation") (:end . 83) (:start . 63) (:id . 53))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 141) (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s805.9) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007516@unknown@formal@none@1@S@This results in increased transcription of NF-kappa B-dependent-genes, including those encoding p105 and I kappa B alpha (MAD3).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "B-dependent-gene") (:form . "B-dependent-genes")\n  (:end . 69) (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "MAD3") (:form . "MAD3") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s805.10) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007517@unknown@formal@none@1@S@These results indicate that LMP-1 activates NF-kappa B in B-cell lines by targeting I kappa B alpha.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "target") (:form . "targeting") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x805.11.1) (:span 14 27)))\n (:hscopes ((:id . :x805.11.1) (:span 14 99)))\n (:identifiers (:sid . :s805.11) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007518@unknown@formal@none@1@S@Identification of the pathways activated by LMP-1 to result in posttranslational modifications of I kappa B alpha will aid in determining the role of this virus-host cell protein interaction in Epstein-Barr virus-mediated oncogenesis.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lmp-1") (:form . "LMP-1") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "posttranslational") (:form . "posttranslational")\n  (:end . 80) (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 94) (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "VB") (:stem . "aid") (:form . "aid") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 137)\n  (:start . 126) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "virus-host") (:form . "virus-host") (:end . 165)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 190)\n  (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 206)\n  (:start . 194) (:id . 72))\n ((:tag . "JJ") (:stem . "virus-mediated") (:form . "virus-mediated")\n  (:end . 221) (:start . 207) (:id . 73))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 233)\n  (:start . 222) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s805.12) (:did . :|7884865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007520@unknown@formal@none@1@S@OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines.@(((:tag . "NNS") (:stem . "objectives") (:form . "OBJECTIVES") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "To") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 65) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RARs") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "t-lymphoid") (:form . "T-lymphoid") (:end . 162)\n  (:start . 152) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 177)\n  (:start . 167) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 188)\n  (:start . 183) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s806.2) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007521@unknown@formal@none@1@S@DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection.@(((:tag . "NN") (:stem . "design") (:form . "DESIGN") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "t-lymphoid") (:form . "T-lymphoid") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "monocytoid") (:form . "monocytoid") (:end . 115)\n  (:start . 105) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . "NN") (:stem . "U937,THP-1") (:form . "U937,THP-1") (:end . 127)\n  (:start . 117) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 139)\n  (:start . 134) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 152)\n  (:start . 144) (:id . 71))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 159)\n  (:start . 153) (:id . 72))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 165)\n  (:start . 160) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 177)\n  (:start . 170) (:id . 75))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 187)\n  (:start . 178) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s806.3) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007522@unknown@formal@none@1@S@The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "hRAR") (:form . "hRAR") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "retinoid-X") (:form . "retinoid-X") (:end . 105)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "hRXR") (:form . "hRXR") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 132)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 160) (:start . 156)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 171)\n  (:start . 161) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 74))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 183)\n  (:start . 175) (:id . 75))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 188) (:start . 184)\n  (:id . 76))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 197)\n  (:start . 189) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s806.4) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007523@unknown@formal@none@1@S@RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA).@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 64)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "iiib-infected") (:form . "IIIB-infected")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "co-stimulatory") (:form . "co-stimulatory")\n  (:end . 155) (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 179)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x806.5.1) (:span 126 133)))\n (:nscopes ((:id . :x806.5.1) (:span 126 193)))\n (:identifiers (:sid . :s806.5) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007524@unknown@formal@none@1@S@The retinoids had weak or no stimulatory effects on HIV production by T-cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x806.6.1) (:span 26 28)))\n (:nscopes ((:id . :x806.6.1) (:span 26 82)))\n (:identifiers (:sid . :s806.6) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007525@unknown@formal@none@1@S@HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids.@(((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pma-stimulated") (:form . "PMA-stimulated")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s806.7) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007526@unknown@formal@none@1@S@The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "all-trans") (:form . "all-trans") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s806.8) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007527@unknown@formal@none@1@S@Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 69)\n  (:start . 63) (:id . 56))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 82)\n  (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s806.9) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007528@unknown@formal@none@1@S@Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RXR") (:form . "RXR") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h9") (:form . "H9") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x806.10.1) (:span 102 105)))\n (:nscopes ((:id . :x806.10.1) (:span 102 129)))\n (:identifiers (:sid . :s806.10) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007530@unknown@formal@none@1@S@Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 111)\n  (:start . 100) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s806.12) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007531@unknown@formal@none@1@S@CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cell-type-dependent")\n  (:form . "cell-type-dependent") (:end . 72) (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RARs") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s806.13) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007532@unknown@formal@none@1@S@Endogenous or exogenously administered RA may have a significant role in HIV regulation.@(((:tag . "JJ") (:stem . "endogenous") (:form . "Endogenous") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "exogenously") (:form . "exogenously") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "administer") (:form . "administered") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x806.14.1) (:span 42 45)))\n (:hscopes ((:id . :x806.14.1) (:span 42 87)))\n (:identifiers (:sid . :s806.14) (:did . :|7888116|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007533@unknown@formal@none@1@S@Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721]@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tr2") (:form . "TR2") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "orphan") (:form . "orphan") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 83) (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 119)\n  (:start . 114) (:id . 58))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 142)\n  (:start . 134) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 161)\n  (:start . 154) (:id . 65))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Biol") (:form . "Biol") (:end . 179) (:start . 175)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Chem") (:form . "Chem") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "CD") (:stem . "1995") (:form . "1995") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "IN") (:stem . "nov") (:form . "Nov") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "CD") (:stem . "3;270(44):26721") (:form . "3;270(44):26721")\n  (:end . 209) (:start . 194) (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 210) (:start . 209)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s807.1) (:did . :|7890658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007534@unknown@formal@none@1@S@A DNA response element (TR2RE-SV40) for the TR2 orphan receptor, a member of the steroid-thyroid hormone receptor superfamily, has been identified in the simian virus 40 (SV40) +55 region (nucleotide numbers 368-389, 5'-GTTAAGGTTCGTAGGTCATGGA-3').@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TR2RE-SV40") (:form . "TR2RE-SV40") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tr2") (:form . "TR2") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "orphan") (:form . "orphan") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "steroid-thyroid") (:form . "steroid-thyroid")\n  (:end . 96) (:start . 81) (:id . 59))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 125)\n  (:start . 114) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 146)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 160)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 175) (:start . 171)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 74))\n ((:tag . "CD") (:stem . "+55") (:form . "+55") (:end . 180) (:start . 177)\n  (:id . 75))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 187)\n  (:start . 181) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 77))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 199)\n  (:start . 189) (:id . 78))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 207)\n  (:start . 200) (:id . 79))\n ((:tag . "CD") (:stem . "368-389") (:form . "368-389") (:end . 215)\n  (:start . 208) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "5'-GTTAAGGTTCGTAGGTCATGGA-3")\n  (:form . "5'-GTTAAGGTTCGTAGGTCATGGA-3") (:end . 244) (:start . 217)\n  (:id . 82))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 245) (:start . 244)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 246) (:start . 245)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s807.2) (:did . :|7890658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007535@unknown@formal@none@1@S@Electrophoretic mobility shift assay, using in vitro translated TR2 orphan receptor with a molecular mass of 67 kilodaltons, showed a specific binding with high affinity (dissociation constant = 9 nM) for this DNA sequence.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "tr2") (:form . "TR2") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "orphan") (:form . "orphan") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "CD") (:stem . "67") (:form . "67") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "kilodalton") (:form . "kilodaltons") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 183)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "constant") (:form . "constant") (:end . 192)\n  (:start . 184) (:id . 71))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "nm") (:form . "nM") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 209) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 213) (:start . 210)\n  (:id . 78))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 222)\n  (:start . 214) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s807.3) (:did . :|7890658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007536@unknown@formal@none@1@S@DNA-swap experiments using chloramphenicol acetyl-transferase assay demonstrated that androgen can suppress the transcriptional activities of SV40 early promoter via the interaction between this TR2RE-SV40 and the chimeric receptor AR/TR2/AR with the DNA-binding domain of the TR2 orphan receptor flanked by the N-terminal and androgen-binding domains of the androgen receptor.@(((:tag . "JJ") (:stem . "dna-swap") (:form . "DNA-swap") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 26) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 42) (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "acetyl-transferase") (:form . "acetyl-transferase")\n  (:end . 61) (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "assay") (:form . 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"of") (:end . 354) (:start . 352)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 358) (:start . 355)\n  (:id . 88))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 367)\n  (:start . 359) (:id . 89))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 376)\n  (:start . 368) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 377) (:start . 376)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s807.4) (:did . :|7890658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007537@unknown@formal@none@1@S@In addition, this TR2RE-SV40 can function as a repressor to suppress the transcriptional activities of both SV40 early and late promoters.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tr2re-sv40") (:form . "TR2RE-SV40") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 88) (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s807.5) (:did . :|7890658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007538@unknown@formal@none@1@S@Together, these data suggest the TR2RE-SV40 may represent the first identified natural DNA response element for the TR2 orphan receptor that may function as a repressor for the SV40 gene expression.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tr2re-sv40") (:form . "TR2RE-SV40") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tr2") (:form . "TR2") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "orphan") (:form . "orphan") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 168)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SV40") (:form . "SV40") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x807.6.1) (:span 141 144)) ((:id . :x807.6.2) (:span 44 47))\n  ((:id . :x807.6.3) (:span 21 28)))\n (:hscopes ((:id . :x807.6.1) (:span 141 197))\n  ((:id . :x807.6.2) (:span 44 197)) ((:id . :x807.6.3) (:span 21 197)))\n (:identifiers (:sid . :s807.6) (:did . :|7890658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007540@unknown@formal@none@1@S@We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 54) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "clone-13") (:form . "Clone-13") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "-DP") (:form . "-DP") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x808.2.1) (:span 105 112)))\n (:nscopes ((:id . :x808.2.1) (:span 105 130)))\n (:identifiers (:sid . :s808.2) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007541@unknown@formal@none@1@S@Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "isotype-specific") (:form . "isotype-specific")\n  (:end . 107) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x808.3.1) (:span 17 31)))\n (:hscopes ((:id . :x808.3.1) (:span 17 128)))\n (:identifiers (:sid . :s808.3) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007542@unknown@formal@none@1@S@Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "VBZ") (:stem . "operate") (:form . "operates") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 146)\n  (:start . 139) (:id . 61))\n ((:tag . "CD") (:stem . "-141") (:form . "-141") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 156) (:start . 152)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 162)\n  (:start . 157) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 184) (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 195)\n  (:start . 185) (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 200) (:start . 196)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x808.4.1) (:span 70 84)))\n (:hscopes ((:id . :x808.4.1) (:span 70 200)))\n (:identifiers (:sid . :s808.4) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007543@unknown@formal@none@1@S@A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "DRA/DQB") (:form . "DRA/DQB") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "VB") (:stem . "map") (:form . "map") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 101)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s808.5) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007544@unknown@formal@none@1@S@Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.@(((:tag . "NN") (:stem . "insertion") (:form . "Insertion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 29) (:start . 13) (:id . 44))\n ((:tag . "VBG") (:stem . "span") (:form . "spanning") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "X-box") (:form . "X-box") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DQB-W") (:form . "DQB-W") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Y-box") (:form . "Y-box") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-141") (:form . "-141") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 131)\n  (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 168)\n  (:start . 162) (:id . 71))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 185)\n  (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x808.6.1) (:span 58 61)))\n (:nscopes ((:id . :x808.6.1) (:span 58 95)))\n (:identifiers (:sid . :s808.6) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007545@unknown@formal@none@1@S@Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.@(((:tag . "NN") (:stem . "substitution") (:form . "Substitution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "x-box") (:form . "X-box") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNPS") (:stem . "X1-") (:form . "X1-") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNPS") (:stem . "X2-box") (:form . "X2-boxes") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HLA-DQB") (:form . "HLA-DQB") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s808.7) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007546@unknown@formal@none@1@S@The DQB X2-box was able to restore expression to the silent DRA reporter construct.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "X2-box") (:form . "X2-box") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "silent") (:form . "silent") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s808.8) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007547@unknown@formal@none@1@S@Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "X2-box") (:form . "X2-box") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "X2-box") (:form . "X2-box") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s808.9) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007548@unknown@formal@none@1@S@None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.@(((:tag . "NN") (:stem . "none") (:form . "None") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HLA-DR/-DQ") (:form . "HLA-DR/-DQ") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jijoye") (:form . "Jijoye") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x808.10.1) (:span 0 4)))\n (:nscopes ((:id . :x808.10.1) (:span 0 137)))\n (:identifiers (:sid . :s808.10) (:did . :|7890777|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007550@unknown@formal@none@1@S@[Regulation of transcription of the interleukin-2 gene in B-lymphocytes]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 11)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocytes")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s809.1) (:did . :|7892566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007551@unknown@formal@none@1@S@Since most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "immortalize") (:form . "immortalized") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 131)\n  (:start . 124) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 153)\n  (:start . 144) (:id . 69))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 183)\n  (:start . 175) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 191) (:start . 187)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 198)\n  (:start . 192) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 201) (:start . 199)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 214)\n  (:start . 202) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s809.2) (:did . :|7892566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007552@unknown@formal@none@1@S@It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 27)\n  (:start . 17) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "NNP") (:stem . "TCEd") (:form . "TCEd") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 110)\n  (:start . 104) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 64))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 117) (:start . 114)\n  (:id . 65))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 123)\n  (:start . 118) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 132)\n  (:start . 126) (:id . 68))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 139)\n  (:start . 133) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s809.3) (:did . :|7892566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007553@unknown@formal@none@1@S@This element has no activity in T cells of the Jurkat line.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x809.4.1) (:span 17 19)))\n (:nscopes ((:id . :x809.4.1) (:span 17 58)))\n (:identifiers (:sid . :s809.4) (:did . :|7892566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007554@unknown@formal@none@1@S@The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nfatd") (:form . "NFATd") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "nfat-1") (:form . "NFAT-1") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 130)\n  (:start . 125) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 138) (:start . 135)\n  (:id . 69))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 141) (:start . 139)\n  (:id . 70))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 145) (:start . 142)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 72))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 156)\n  (:start . 149) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x809.5.1) (:span 135 138)))\n (:nscopes ((:id . :x809.5.1) (:span 135 156)))\n (:identifiers (:sid . :s809.5) (:did . :|7892566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007555@unknown@formal@none@1@S@Different elements thus contribute to IL-2 promoter activity in different cells.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s809.6) (:did . :|7892566|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007556@unknown@formal@none@1@S@ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.@(((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 10) (:start . 7)\n  (:id . 45))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 17)\n  (:start . 11) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 28) (:start . 25)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 50))\n ((:tag . "NN") (:stem . "factor/oncoprotein") (:form . "factor/oncoprotein")\n  (:end . 61) (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 95) (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 113)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 144) (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 156)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s810.1) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007557@unknown@formal@none@1@S@The ets gene family encodes a group of proteins which function as transcription factors under physiological conditions and, if aberrantly expressed, can cause cellular transformation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 107) (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "RB") (:stem . "aberrantly") (:form . "aberrantly") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 182) (:start . 168) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s810.2) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007558@unknown@formal@none@1@S@We have recently identified two regulatory elements in the murine immunoglobulin heavy-chain (IgH) enhancer, pi and microB, which exhibit striking similarity to binding sites for ets-related proteins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 80) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 92)\n  (:start . 81) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pi") (:form . "pi") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "microb") (:form . "microB") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 157)\n  (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 168)\n  (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 174)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "ets-related") (:end . 190)\n  (:start . 179) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 199)\n  (:start . 191) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s810.3) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007560@unknown@formal@none@1@S@We have cloned the gene for a new ets-related transcription factor, ERP (ets-related protein), from the murine pre-B cell line BASC 6C2 and from mouse lung tissue.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "ets-related") (:end . 45)\n  (:start . 34) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ets-related") (:form . "ets-related") (:end . 84)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 116)\n  (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BASC") (:form . "BASC") (:end . 131) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "6c2") (:form . "6C2") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 144) (:start . 140)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 150)\n  (:start . 145) (:id . 70))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 155) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 162)\n  (:start . 156) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s810.5) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007561@unknown@formal@none@1@S@The ERP protein contains a region of high homology with the ETS DNA-binding domain common to all members of the ets transcription factor/oncoprotein family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ets") (:form . "ETS") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "factor/oncoprotein") (:form . "factor/oncoprotein")\n  (:end . 148) (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s810.6) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007562@unknown@formal@none@1@S@Three additional smaller regions show homology to the ELK-1 and SAP-1 genes, a subgroup of the ets gene family that interacts with the serum response factor.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "elk-1") (:form . "ELK-1") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sap-1") (:form . "SAP-1") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "subgroup") (:form . "subgroup") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 156)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s810.7) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007563@unknown@formal@none@1@S@Full-length ERP expresses only negligible DNA-binding activity by itself.@(((:tag . "JJ") (:stem . "full-length") (:form . "Full-length") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "negligible") (:form . "negligible") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 72)\n  (:start . 66) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s810.8) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007564@unknown@formal@none@1@S@Removal of the carboxy terminus enables ERP to interact with a variety of ets-binding sites including the E74 site, the IgH enhancer pi site, and the lck promoter ets site, suggesting a carboxy-terminal negative regulatory domain.@(((:tag . "NNP") (:stem . "Removal") (:form . "Removal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "carboxy") (:form . "carboxy") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "enable") (:form . "enables") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ets-binding") (:form . "ets-binding") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "e74") (:form . "E74") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "pi") (:form . "pi") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lck") (:form . "lck") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 162)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 171) (:start . 167)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 183)\n  (:start . 173) (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 202) (:start . 186) (:id . 77))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 211)\n  (:start . 203) (:id . 78))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 222)\n  (:start . 212) (:id . 79))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 229)\n  (:start . 223) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x810.9.1) (:span 173 183)))\n (:hscopes ((:id . :x810.9.1) (:span 173 229)))\n (:identifiers (:sid . :s810.9) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007565@unknown@formal@none@1@S@At least three ERP-related transcripts are expressed in a variety of tissues.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "erp-related") (:form . "ERP-related") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s810.10) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007566@unknown@formal@none@1@S@However, within the B-cell lineage, ERP is highly expressed primarily at early stages of B-lymphocyte development, and expression declines drastically upon B-cell maturation, correlating with the enhancer activity of the IgH pi site.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte")\n  (:end . 101) (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "VBZ") (:stem . "decline") (:form . "declines") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "RB") (:stem . "drastically") (:form . "drastically") (:end . 150)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 173)\n  (:start . 163) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "correlate") (:form . "correlating") (:end . 186)\n  (:start . 175) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 213)\n  (:start . 205) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 224) (:start . 221)\n  (:id . 76))\n ((:tag . "NN") (:stem . "pi") (:form . "pi") (:end . 227) (:start . 225)\n  (:id . 77))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 232) (:start . 228)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s810.11) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007567@unknown@formal@none@1@S@These data suggest that ERP might play a role in B-cell development and in IgH gene regulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ERP") (:form . "ERP") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x810.12.1) (:span 28 33))\n  ((:id . :x810.12.2) (:span 11 18)))\n (:hscopes ((:id . :x810.12.1) (:span 28 94))\n  ((:id . :x810.12.2) (:span 11 94)))\n (:identifiers (:sid . :s810.12) (:did . :|7909357|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007568@unknown@formal@none@1@S@NF-kappa B-dependent and -independent pathways of HIV activation in a chronically infected T cell line.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s811.1) (:did . :|7913275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007570@unknown@formal@none@1@S@J delta K cells exhibited very low levels of constitutive HIV production.@(((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 57)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s811.3) (:did . :|7913275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007571@unknown@formal@none@1@S@HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate (PMA), sodium butyrate (NaB), or hexamethylene bisacetamide (HMBA), but not tumor necrosis factor alpha (TNF-alpha), confirming the role of NF-kappa B in mediating TNF-alpha induction of HIV transcription.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "delta") (:form . 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5007572@unknown@formal@none@1@S@The strong induction of HIV expression by NaB or HMBA in J delta K cells clearly demonstrates the existence of NF-kappa B-independent mechanisms of HIV activation in chronically infected cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NaB") (:form . "NaB") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HMBA") (:form . "HMBA") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 80)\n  (:start . 73) (:id . 57))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 93)\n  (:start . 81) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "b-independent") (:form . "B-independent")\n  (:end . 133) (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 177)\n  (:start . 166) (:id . 69))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 192)\n  (:start . 187) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x811.5.1) (:span 46 48)))\n (:hscopes ((:id . :x811.5.1) (:span 42 53)))\n (:identifiers (:sid . :s811.5) (:did . :|7913275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007573@unknown@formal@none@1@S@J delta K cells may provide a useful model for characterizing NF-kappa B-independent transcriptional activation of the HIV LTR.@(((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 36)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "characterize") (:form . "characterizing")\n  (:end . 61) (:start . 47) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "b-independent") (:form . "B-independent")\n  (:end . 84) (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x811.6.1) (:span 16 19)))\n (:hscopes ((:id . :x811.6.1) (:span 16 126)))\n (:identifiers (:sid . :s811.6) (:did . :|7913275|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007574@unknown@formal@none@1@S@Appraisal of potential therapeutic index of antioxidants on the basis of their in vitro effects on HIV replication in monocytes and interleukin 2-induced lymphocyte proliferation.@(((:tag . "NN") (:stem . "appraisal") (:form . "Appraisal") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "index") (:form . "index") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 56)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 78)\n  (:start . 73) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "JJ") (:stem . "2-induced") (:form . "2-induced") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 178) (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x812.1.1) (:span 13 22)))\n (:hscopes ((:id . :x812.1.1) (:span 13 56)))\n (:identifiers (:sid . :s812.1) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007575@unknown@formal@none@1@S@Antioxidant molecules have been suggested to be of therapeutic value in the treatment of HIV-infected patients.@(((:tag . "JJ") (:stem . "antioxidant") (:form . "Antioxidant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 101)\n  (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x812.2.1) (:span 32 41)))\n (:hscopes ((:id . :x812.2.1) (:span 0 110)))\n (:identifiers (:sid . :s812.2) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007576@unknown@formal@none@1@S@To evaluate this possibility, we examined in vitro the effects of two types of antioxidant molecules in terms of inhibition of HIV replication in monocytes, one of the main reservoirs of HIV, and also in terms of modulation of the immune competence as measured by PBMC proliferation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "FW") (:stem . 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"one") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "reservoir") (:form . "reservoirs") (:end . 183)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 190) (:start . 187)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 77))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 200) (:start . 196)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 79))\n ((:tag . 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5007577@unknown@formal@none@1@S@We tested the effects of BHA, a phenolic, lipid-soluble, chain-breaking antioxidant, and NAC, a known glutathione precursor with some direct free-radical scavenging properties as well, on the regulation of HIV-1 expression in latently infected U1 cells and in productively and chronically infected U937 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . 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5007578@unknown@formal@none@1@S@Both antioxidants inhibited TNF- or PMA-induced NF-kappa B activity in U1 cells, as well as the sustained NF-kappa B activity permanently induced by the virus itself in chronically HIV-infected U937 cells.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-") (:form . "TNF-") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "RB") (:stem . "permanently") (:form . "permanently") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 180)\n  (:start . 169) (:id . 70))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 193)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 198) (:start . 194)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s812.5) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007580@unknown@formal@none@1@S@This may be the first limitation to potential antiviral effects of antioxidant therapies.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "limitation") (:form . "limitation") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "therapy") (:form . "therapies") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x812.7.1) (:span 36 45)) ((:id . :x812.7.2) (:span 5 8)))\n (:hscopes ((:id . :x812.7.1) (:span 36 88)) ((:id . :x812.7.2) (:span 5 88)))\n (:identifiers (:sid . :s812.7) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007581@unknown@formal@none@1@S@Another limitation is that antioxidant concentrations high enough to block NK-kappa B activation were shown to have a suppressive effect on immune functions in vitro, because NAC and BHA blocked IL-2-induced PBMC proliferation.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "limitation") (:form . "limitation") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 53) (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NK-kappa") (:form . "NK-kappa") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 174)\n  (:start . 167) (:id . 68))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "BHA") (:form . "BHA") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 194)\n  (:start . 187) (:id . 72))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 207)\n  (:start . 195) (:id . 73))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 212) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 226) (:start . 213) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s812.8) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007582@unknown@formal@none@1@S@These data warrant prudence in the design of antioxidant-based therapies aimed at suppressing HIV replication.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "warrant") (:form . "warrant") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "prudence") (:form . "prudence") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "design") (:form . "design") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antioxidant-based") (:form . "antioxidant-based")\n  (:end . 62) (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "therapy") (:form . "therapies") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "VBN") (:stem . "aim") (:form . "aimed") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s812.9) (:did . :|7915123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007583@unknown@formal@none@1@S@Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa B.@(((:tag . "NNS") (:stem . "signal") (:form . "Signals") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s813.1) (:did . :|7915519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007584@unknown@formal@none@1@S@We have demonstrated that native envelope glycoproteins of HIV-1, gp160 can induce activation of the transcription factor, NF-kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "envelope") (:form . "envelope") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "glycoprotein") (:form . "glycoproteins")\n  (:end . 55) (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gp160") (:form . "gp160") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s813.2) (:did . :|7915519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007585@unknown@formal@none@1@S@The stimulatory effects of gp160 are mediated through the CD4 molecule, since pretreatment with soluble CD4 abrogates its activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gp160") (:form . "gp160") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 90)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "abrogate") (:form . "abrogates") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s813.3) (:did . :|7915519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007586@unknown@formal@none@1@S@The gp160-induced NF-kappa B complex consists of p65, p50 and c-rel proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "gp160-induced") (:form . "gp160-induced")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s813.4) (:did . :|7915519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007587@unknown@formal@none@1@S@The stimulatory effect of gp160 on NF-kappa B activation is protein synthesis independent, is dependent upon protein tyrosine phosphorylation, and abrogated by inhibitors of protein kinase C.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gp160") (:form . "gp160") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 141) (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 170)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s813.5) (:did . :|7915519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007588@unknown@formal@none@1@S@The gp160-mediated activation of NF-kappa B in CD4 positive T cells may be involved in biological effects, e.g., enhanced HIV replication, hypergammaglobulinemia, increased cytokine secretion, hypercellularity in bone marrow and apoptosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "gp160-mediated") (:form . "gp160-mediated")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD4") (:form . "CD4") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 137)\n  (:start . 126) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "hypergammaglobulinemia")\n  (:form . "hypergammaglobulinemia") (:end . 161) (:start . 139) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 172)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 181)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hypercellularity") (:form . "hypercellularity")\n  (:end . 209) (:start . 193) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 73))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 217) (:start . 213)\n  (:id . 74))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 224)\n  (:start . 218) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 76))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 238)\n  (:start . 229) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x813.6.1) (:span 68 71)))\n (:hscopes ((:id . :x813.6.1) (:span 68 238)))\n (:identifiers (:sid . :s813.6) (:did . :|7915519|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007590@unknown@formal@none@1@S@The role of the human immunodeficiency virus (HIV-1) Nef protein in T cell activation pathways was investigated using a Jurkat CD4+ cell line stably transfected with a Nef expression vector.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 38) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 57))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 111)\n  (:start . 99) (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 117) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 148)\n  (:start . 142) (:id . 67))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 160)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 182)\n  (:start . 172) (:id . 72))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 189)\n  (:start . 183) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s814.2) (:did . :|7917514|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5007592@unknown@formal@none@1@S@These parameters were not modified by Nef expression in Jurkat cells, whereas stimulation with the same stimuli resulted in partial inhibition of LTR activation in Nef+ Jurkat cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nef+") (:form . "Nef+") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x814.4.1) (:span 22 25)))\n (:nscopes ((:id . :x814.4.1) (:span 0 68)))\n (:identifiers (:sid . :s814.4) (:did . :|7917514|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007593@unknown@formal@none@1@S@This inhibition was not mediated through Nef phosphorylation on Thr-15 or GTP-binding activity because mutations in critical sites did not alter this inhibition.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Thr-15") (:form . "Thr-15") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "gtp-binding") (:form . "GTP-binding") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x814.5.1) (:span 135 138))\n  ((:id . :x814.5.2) (:span 20 23)))\n (:nscopes ((:id . :x814.5.1) (:span 135 160))\n  ((:id . :x814.5.2) (:span 0 94)))\n (:identifiers (:sid . :s814.5) (:did . :|7917514|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007594@unknown@formal@none@1@S@Analysis of truncated LTRs confirmed that inhibition of LTR activation was not mediated through NF-kappa B-binding activity but through the region containing the negative responding elements (NREs).@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 170)\n  (:start . 162) (:id . 65))\n ((:tag . "VBG") (:stem . "respond") (:form . "responding") (:end . 181)\n  (:start . 171) (:id . 66))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 190)\n  (:start . 182) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 192) (:start . 191)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NREs") (:end . 196) (:start . 192)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x814.6.1) (:span 75 78)))\n (:nscopes ((:id . :x814.6.1) (:span 75 123)))\n (:identifiers (:sid . :s814.6) (:did . :|7917514|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007595@unknown@formal@none@1@S@These results suggest that Nef downmodulates LTR activation without significantly inhibiting the capacity of T cells to respond to immunological activations.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "downmodulate") (:form . "downmodulates")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 81) (:start . 68) (:id . 51))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 105)\n  (:start . 97) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 144) (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "activation") (:form . "activations") (:end . 156)\n  (:start . 145) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x814.7.2) (:span 14 21)))\n (:ncues ((:id . :x814.7.1) (:span 60 67)))\n (:hscopes ((:id . :x814.7.2) (:span 14 156)))\n (:nscopes ((:id . :x814.7.1) (:span 60 156)))\n (:identifiers (:sid . :s814.7) (:did . :|7917514|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007596@unknown@formal@none@1@S@A low NM23.H1 gene expression identifying high malignancy human melanomas.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nm23.h1") (:form . "NM23.H1") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "malignancy") (:form . "malignancy") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "melanoma") (:form . "melanomas") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s815.1) (:did . :|7919963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007597@unknown@formal@none@1@S@The NM23 gene has been proposed as a metastasis-suppressor gene, and its use has been suggested as prognostic factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nm23") (:form . "NM23") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "metastasis-suppressor")\n  (:form . "metastasis-suppressor") (:end . 58) (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "prognostic") (:form . "prognostic") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x815.2.1) (:span 86 95)) ((:id . :x815.2.2) (:span 23 31)))\n (:hscopes ((:id . :x815.2.1) (:span 69 116))\n  ((:id . :x815.2.2) (:span 0 63)))\n (:identifiers (:sid . :s815.2) (:did . :|7919963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007598@unknown@formal@none@1@S@NM23 was identified in a system of murine melanoma cell lines, in which an inverse relationship was found between NM23 expression and metastatic ability.@(((:tag . "NNP") (:stem . "NM23") (:form . "NM23") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "melanoma") (:form . "melanoma") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inverse") (:form . "inverse") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 95)\n  (:start . 83) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "nm23") (:form . "NM23") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "metastatic") (:form . "metastatic") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s815.3) (:did . :|7919963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007600@unknown@formal@none@1@S@The present paper studies the expression of the NM23.H1 gene in cell lines which derive from primary or metastatic human malignant melanomas in relation to staging, infiltration degree, lymphocytic infiltration, cell morphology, cell pigmentation, karyotype, and disease-free survival.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nm23.h1") (:form . "NM23.H1") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "derive") (:form . "derive") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "metastatic") (:form . "metastatic") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "NNS") (:stem . "melanoma") (:form . "melanomas") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "staging") (:form . "staging") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 177)\n  (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 197)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 210)\n  (:start . 198) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 75))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 227)\n  (:start . 217) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 233) (:start . 229)\n  (:id . 78))\n ((:tag . "NN") (:stem . "pigmentation") (:form . "pigmentation") (:end . 246)\n  (:start . 234) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 80))\n ((:tag . "NN") (:stem . "karyotype") (:form . "karyotype") (:end . 257)\n  (:start . 248) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 258) (:start . 257)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "disease-free") (:form . "disease-free") (:end . 275)\n  (:start . 263) (:id . 84))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 284)\n  (:start . 276) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 285) (:start . 284)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s815.5) (:did . :|7919963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007601@unknown@formal@none@1@S@The level of mRNA expression of the NM23 gene is significantly lower in cell lines that derive from more infiltrating primary melanomas than in cell lines obtained from less infiltrating tumours.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nm23") (:form . "NM23") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 62) (:start . 49) (:id . 52))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "derive") (:form . "derive") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "infiltrate") (:form . "infiltrating") (:end . 117)\n  (:start . 105) (:id . 61))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . "NNS") (:stem . "melanoma") (:form . "melanomas") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 163)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "infiltrating") (:form . "infiltrating") (:end . 186)\n  (:start . 174) (:id . 71))\n ((:tag . "NNS") (:stem . "tumour") (:form . "tumours") (:end . 194)\n  (:start . 187) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s815.6) (:did . :|7919963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007602@unknown@formal@none@1@S@Moreover, cell lines derived from tumours of patients with a disease-free survival of more than 24 months (24-58 months) express the NM23 gene at higher levels than cell lines obtained from melanomas of patients with a disease-free survival of less than 24 months (6-15 months).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "tumour") (:form . "tumours") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . 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5007603@unknown@formal@none@1@S@T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "b-specific") (:form . "B-specific") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 126)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s816.1) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007604@unknown@formal@none@1@S@Recent data suggest that the poor induction of a T-cell response to human renal cell carcinoma (RCC) may be related to alterations in signal transduction pathways.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 130)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 140)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 153)\n  (:start . 141) (:id . 68))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x816.2.1) (:span 101 104))\n  ((:id . :x816.2.2) (:span 12 19)))\n (:hscopes ((:id . :x816.2.1) (:span 101 162))\n  ((:id . :x816.2.2) (:span 12 162)))\n (:identifiers (:sid . :s816.2) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007605@unknown@formal@none@1@S@We report that T cells from RCC patients have two alterations in kappa B motif-specific DNA-binding activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "motif-specific") (:form . "motif-specific")\n  (:end . 87) (:start . 73) (:id . 56))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s816.3) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007606@unknown@formal@none@1@S@The first alteration involves the constitutive expression of substantial kappa B-binding activity in nuclear extracts, which was observed in the electrophoretic mobility shift assay.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 72)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 160) (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 169)\n  (:start . 161) (:id . 64))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 175)\n  (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 181)\n  (:start . 176) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s816.4) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007607@unknown@formal@none@1@S@The magnitude of kappa B activity in unstimulated patient T cells was similar to that observed in T cells from normal individuals that had been activated in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 49)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 129)\n  (:start . 118) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 153)\n  (:start . 144) (:id . 67))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s816.5) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007608@unknown@formal@none@1@S@On the basis of Western blotting experiments using antibodies to kappa B/Rel family proteins, the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 (p50) subunit.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 137) (:start . 123) (:id . 61))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 195)\n  (:start . 189) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 211)\n  (:start . 203) (:id . 74))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 214) (:start . 212)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 78))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 228)\n  (:start . 221) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s816.6) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007610@unknown@formal@none@1@S@Western blotting analysis did not detect any RelA in nuclear extracts either before or after stimulation of T cells.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rela") (:form . "RelA") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x816.8.1) (:span 30 33)))\n (:nscopes ((:id . :x816.8.1) (:span 30 115)))\n (:identifiers (:sid . :s816.8) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007611@unknown@formal@none@1@S@The altered kappa B-binding activity in T cells from RCC patients may impair their capacity to respond normally to various stimuli.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "impair") (:form . "impair") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 82)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x816.9.1) (:span 66 69)))\n (:hscopes ((:id . :x816.9.1) (:span 66 130)))\n (:identifiers (:sid . :s816.9) (:did . :|7923175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007612@unknown@formal@none@1@S@Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "phosphorylation") (:form . "phosphorylations")\n  (:end . 74) (:start . 58) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s817.1) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007613@unknown@formal@none@1@S@The activation of nuclear factor kappa B (NF-kappa B) in intact cells is mechanistically not well understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "RB") (:stem . "mechanistically") (:form . "mechanistically")\n  (:end . 88) (:start . 73) (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s817.2) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007614@unknown@formal@none@1@S@Therefore we investigated the modifications imposed on NF-kappa B/I kappa B components following stimulation and show that the final step of NF-kappa B induction in vivo involves phosphorylation of several members of the NF-kappa B/I kappa B protein families.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "VBN") (:stem . "impose") (:form . "imposed") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NNP") (:stem . "B/I") (:form . "B/I") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 108)\n  (:start . 97) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 178)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 194) (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 205)\n  (:start . 198) (:id . 71))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 213)\n  (:start . 206) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 229)\n  (:start . 221) (:id . 75))\n ((:tag . "NNP") (:stem . "B/I") (:form . "B/I") (:end . 233) (:start . 230)\n  (:id . 76))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 239)\n  (:start . 234) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 241) (:start . 240)\n  (:id . 78))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 249)\n  (:start . 242) (:id . 79))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 258)\n  (:start . 250) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s817.3) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007615@unknown@formal@none@1@S@In HeLa cells as well as in B cells, TNF-alpha rapidly induced nuclear translocation primarily of p50-p65, but not of c-rel.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 46)\n  (:start . 37) (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 84) (:start . 71) (:id . 56))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x817.4.1) (:span 111 114)))\n (:nscopes ((:id . :x817.4.1) (:span 111 123)))\n (:identifiers (:sid . :s817.4) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007616@unknown@formal@none@1@S@Both NF-kappa B precursors and I kappa B alpha became strongly phosphorylated with the same kinetics.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "become") (:form . "became") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 77) (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s817.5) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007617@unknown@formal@none@1@S@In addition to the inducible phosphorylation after stimulation, B lymphocytes containing constitutive nuclear NF-kappa B revealed constitutively phosphorylated p65 and I kappa B alpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 44) (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 101)\n  (:start . 89) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 118)\n  (:start . 110) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 129)\n  (:start . 121) (:id . 58))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 144) (:start . 130) (:id . 59))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 159) (:start . 145) (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 163) (:start . 160)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 62))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 169) (:start . 168)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 175)\n  (:start . 170) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 177) (:start . 176)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 183)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s817.6) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007618@unknown@formal@none@1@S@Phosphorylation was accompanied by induced processing of the precursors p100 and p105 and by degradation of I kappa B alpha.@(((:tag . "NNP") (:stem . "Phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s817.7) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007620@unknown@formal@none@1@S@Surprisingly, even p65, but not c-rel, was phosphorylated after induction in vivo, suggesting that TNF-alpha selectively activates only specific NF-kappa B heteromers and that modifications regulate not only I kappa B molecules but also NF-kappa B molecules.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 57) (:start . 43) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "heteromer") (:form . "heteromers") (:end . 166)\n  (:start . 156) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 189) (:start . 176) (:id . 70))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 198)\n  (:start . 190) (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 202) (:start . 199)\n  (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 207) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 209) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 215)\n  (:start . 210) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 217) (:start . 216)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 227)\n  (:start . 218) (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 231) (:start . 228)\n  (:id . 78))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 236) (:start . 232)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 245)\n  (:start . 237) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 247) (:start . 246)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 257)\n  (:start . 248) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x817.9.1) (:span 83 93)))\n (:ncues ((:id . :x817.9.2) (:span 28 31)))\n (:hscopes ((:id . :x817.9.1) (:span 83 257)))\n (:nscopes ((:id . :x817.9.2) (:span 28 37)))\n (:identifiers (:sid . :s817.9) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007621@unknown@formal@none@1@S@In fact, cellular NF-kappa B activity was phosphorylation-dependent and the DNA binding activity of p65-containing NF-kappa B was enhanced by phosphorylation in vitro.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "phosphorylation-dependent")\n  (:form . "phosphorylation-dependent") (:end . 67) (:start . 42) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "p65-containing") (:form . "p65-containing")\n  (:end . 114) (:start . 100) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 157) (:start . 142) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s817.10) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007622@unknown@formal@none@1@S@Furthermore, we found that the induction by hydrogen peroxide of NF-kappa B translocation to the nucleus, which is assumed to be triggered by reactive oxygen intermediates, also coincided with incorporation of phosphate into the same subunits that were modified after stimulation by TNF-alpha.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 157)\n  (:start . 151) (:id . 68))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 171) (:start . 158) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "coincide") (:form . "coincided") (:end . 187)\n  (:start . 178) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 206) (:start . 193) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phosphate") (:form . "phosphate") (:end . 219)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 224) (:start . 220)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 233) (:start . 229)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 242)\n  (:start . 234) (:id . 80))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 247) (:start . 243)\n  (:id . 81))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 252) (:start . 248)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 261)\n  (:start . 253) (:id . 83))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 267)\n  (:start . 262) (:id . 84))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 279)\n  (:start . 268) (:id . 85))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 282) (:start . 280)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 292)\n  (:start . 283) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s817.11) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007623@unknown@formal@none@1@S@Thus, phosphorylation appears to be a general mechanism for activation of NF-kappa B in vivo.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 21) (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x817.12.1) (:span 22 29)))\n (:hscopes ((:id . :x817.12.1) (:span 6 92)))\n (:identifiers (:sid . :s817.12) (:did . :|7925300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007624@unknown@formal@none@1@S@An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "v-abl") (:form . "v-abl") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 61) (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "light-chain") (:form . "light-chain") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 92) (:start . 79) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s818.1) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007625@unknown@formal@none@1@S@Lymphoid cells transformed by Abelson murine leukemia virus have provided one of the classic models for study of early B-cell development and immunoglobulin rearrangement.@(((:tag . "JJ") (:stem . "lymphoid") (:form . "Lymphoid") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Abelson") (:form . "Abelson") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "classic") (:form . "classic") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 137)\n  (:start . 126) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 156) (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 170) (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s818.2) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007626@unknown@formal@none@1@S@Most of these cells have rearranged their heavy-chain locus but not their light chain genes, suggesting that an active v-abl protein interferes with this differentiation step.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "rearrange") (:form . "rearranged") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 41)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 73)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "v-abl") (:form . "v-abl") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 143)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 169) (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x818.3.1) (:span 93 103)))\n (:ncues ((:id . :x818.3.2) (:span 64 67)))\n (:hscopes ((:id . :x818.3.1) (:span 93 174)))\n (:nscopes ((:id . :x818.3.2) (:span 64 91)))\n (:identifiers (:sid . :s818.3) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007627@unknown@formal@none@1@S@To test this hypothesis, light-chain gene structure was examined in pre-B cells transformed by temperature-sensitive mutants of the Abelson virus and in derivatives that survive at the nonpermissive temperature because they express a human BCL-2 gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "light-chain") (:form . "light-chain") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "temperature-sensitive")\n  (:form . "temperature-sensitive") (:end . 116) (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Abelson") (:form . "Abelson") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 145)\n  (:start . 140) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 164)\n  (:start . 153) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "survive") (:form . "survive") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "nonpermissive") (:form . "nonpermissive")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "temperature") (:form . "temperature") (:end . 210)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 218)\n  (:start . 211) (:id . 72))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 223) (:start . 219)\n  (:id . 73))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 231)\n  (:start . 224) (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 233) (:start . 232)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 239)\n  (:start . 234) (:id . 76))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "BCL-2") (:end . 245)\n  (:start . 240) (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 250) (:start . 246)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s818.4) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007628@unknown@formal@none@1@S@Our studies reveal that inactivation of the v-abl protein tyrosine kinase triggers high-frequency rearrangement of kappa and lambda light-chain genes.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "v-abl") (:form . "v-abl") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "high-frequency") (:form . "high-frequency")\n  (:end . 97) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 111) (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lambda") (:form . "lambda") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . "JJ") (:stem . "light-chain") (:form . "light-chain") (:end . 143)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s818.5) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007630@unknown@formal@none@1@S@These increases occur in the absence of protein synthesis but are dependent on inactivation of the v-abl protein tyrosine kinase.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "v-abl") (:form . "v-abl") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x818.7.1) (:span 29 36)))\n (:nscopes ((:id . :x818.7.1) (:span 29 57)))\n (:identifiers (:sid . :s818.7) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007631@unknown@formal@none@1@S@As documented in the accompanying paper (Klug et al., this issue), an active v-abl protein also suppresses the activity of NF-kappa B/rel and expression controlled by the kappa intron enhancer.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "document") (:form . "documented") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "accompany") (:form . "accompanying") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Klug") (:form . "Klug") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 76)\n  (:start . 70) (:id . 58))\n ((:tag . "JJ") (:stem . "v-abl") (:form . "v-abl") (:end . 82) (:start . 77)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 106)\n  (:start . 96) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 131)\n  (:start . 123) (:id . 66))\n ((:tag . "NNP") (:stem . "B/rel") (:form . "B/rel") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 69))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 163)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 176)\n  (:start . 171) (:id . 73))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 183)\n  (:start . 177) (:id . 74))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 192)\n  (:start . 184) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s818.8) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007632@unknown@formal@none@1@S@Together these data demonstrate that the v-abl protein specifically interferes with light-chain gene rearrangement by suppressing at least two pathways essential for this stage of B-cell differentiation and suggest that tyrosine phosphorylation is important in regulating RAG gene expression.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "v-abl") (:form . "v-abl") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 67)\n  (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "light-chain") (:form . "light-chain") (:end . 95)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rearrangement") (:form . "rearrangement")\n  (:end . 114) (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 129)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 138)\n  (:start . 133) (:id . 59))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 142) (:start . 139)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 151)\n  (:start . 143) (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 161)\n  (:start . 152) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 170) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 176)\n  (:start . 171) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 66))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 186)\n  (:start . 180) (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 202) (:start . 187) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 214)\n  (:start . 207) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 219) (:start . 215)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 228)\n  (:start . 220) (:id . 72))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 244) (:start . 229) (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 247) (:start . 245)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 257)\n  (:start . 248) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 260) (:start . 258)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 271)\n  (:start . 261) (:id . 77))\n ((:tag . "NNP") (:stem . "RAG") (:form . "RAG") (:end . 275) (:start . 272)\n  (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 280) (:start . 276)\n  (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 291)\n  (:start . 281) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x818.9.1) (:span 207 214)))\n (:hscopes ((:id . :x818.9.1) (:span 207 291)))\n (:identifiers (:sid . :s818.9) (:did . :|7926759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007633@unknown@formal@none@1@S@[An overexpression of retinoic acid receptor alpha blocks myeloid cell differentiation at the promyelocyte stage]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "An") (:end . 3) (:start . 1)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 18) (:start . 4) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 86) (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 106)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s819.1) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007634@unknown@formal@none@1@S@Retinoic acid (RA), a vitamin A derivative, exerts a wide range of biological effects related to cell proliferation and differentiation.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 29)\n  (:start . 22) (:id . 49))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 31) (:start . 30)\n  (:id . 50))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 42)\n  (:start . 32) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 50)\n  (:start . 44) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 57) (:start . 53)\n  (:id . 55))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 63) (:start . 58)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 77)\n  (:start . 67) (:id . 58))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 85)\n  (:start . 78) (:id . 59))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 115) (:start . 102) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 135) (:start . 120) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s819.2) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007635@unknown@formal@none@1@S@The pleiotropic effects of RA are thought to be mediated through specific nuclear RA receptors (RARs).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RARs") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x819.3.1) (:span 34 41)))\n (:hscopes ((:id . :x819.3.1) (:span 0 101)))\n (:identifiers (:sid . :s819.3) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007636@unknown@formal@none@1@S@RARs are members of the steroid/thyroid hormone receptor superfamily and exhibit a molecular structure that possess discrete DNA-binding and RA (ligand)-binding domains.@(((:tag . "NNS") (:stem . "rar") (:form . "RARs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "steroid/thyroid") (:form . "steroid/thyroid")\n  (:end . 39) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "possess") (:form . "possess") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "discrete") (:form . "discrete") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 136)\n  (:start . 125) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ligand)-binding") (:form . "ligand)-binding")\n  (:end . 160) (:start . 145) (:id . 63))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 168)\n  (:start . 161) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s819.4) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007637@unknown@formal@none@1@S@In hematopoietic system, RA and RARs, predominantly RAR alpha may play key roles for the proliferation and differentiation of hematopoietic progenitors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RARs") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 51) (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 102) (:start . 89) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 122) (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 139) (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x819.5.1) (:span 62 65)))\n (:hscopes ((:id . :x819.5.1) (:span 62 151)))\n (:identifiers (:sid . :s819.5) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007638@unknown@formal@none@1@S@However, it is currently unknown how RA and RARs are involved in regulating normal hematopoietic differentiation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RARs") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 75)\n  (:start . 65) (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 96) (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 112) (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x819.6.1) (:span 25 32)))\n (:hscopes ((:id . :x819.6.1) (:span 25 112)))\n (:identifiers (:sid . :s819.6) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007640@unknown@formal@none@1@S@All of procedure were done in vitro.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 36) (:start . 35)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s819.8) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007641@unknown@formal@none@1@S@Most cells infected with hRAR alpha exhibited promyelocytic morphology and were thought to be blocked at the promyelocytic stage in their myeloid differentiation.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "hRAR") (:form . "hRAR") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 161) (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x819.9.1) (:span 80 87)))\n (:hscopes ((:id . :x819.9.1) (:span 75 161)))\n (:identifiers (:sid . :s819.9) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007642@unknown@formal@none@1@S@Furthermore, these immature cells differentiated terminally into mature granulocytes by adding with RA (10(-6) M).@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "RB") (:stem . "terminally") (:form . "terminally") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 84)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "add") (:form . "adding") (:end . 94) (:start . 88)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "10(-6)") (:form . "10(-6)") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s819.10) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007643@unknown@formal@none@1@S@RAR alpha infected cells were also able to differentiate into mature macrophages in the both of long term culture and IL3 colony.@(((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il3") (:form . "IL3") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s819.11) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007644@unknown@formal@none@1@S@These observations suggest that an overexpression of RAR alpha alone is effective to suppress myeloid cell differentiation and RAR alpha plays a crucial role in the terminal differentiation of myeloid precursors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 49) (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 122) (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 189) (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 211)\n  (:start . 201) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x819.12.1) (:span 19 26)))\n (:hscopes ((:id . :x819.12.1) (:span 19 211)))\n (:identifiers (:sid . :s819.12) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007645@unknown@formal@none@1@S@The system described here may serve as a model for studying the the essential genes for differentiation of normal bone marrow cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 103) (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x819.13.1) (:span 26 29)))\n (:hscopes ((:id . :x819.13.1) (:span 26 131)))\n (:identifiers (:sid . :s819.13) (:did . :|7927175|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007646@unknown@formal@none@1@S@Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "factor.kappa") (:form . "factor.kappa") (:end . 84)\n  (:start . 72) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 117) (:start . 116)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 134)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s820.1) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007647@unknown@formal@none@1@S@Autocrine role of tumor necrosis factor alpha.@(((:tag . "NNP") (:stem . "Autocrine") (:form . "Autocrine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s820.2) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007648@unknown@formal@none@1@S@The regulation of interleukin-2 receptor alpha chain (IL-2R alpha) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 149)\n  (:start . 142) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 151) (:start . 150)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 162) (:start . 159)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 167) (:start . 163)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 175)\n  (:start . 168) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s820.3) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5007651@unknown@formal@none@1@S@Interestingly, all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor alpha (TNF alpha), as they were strongly inhibited by a neutralizing anti-TNF alpha monoclonal antibody.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "endogenously") (:form . "endogenously") (:end . 85)\n  (:start . 73) (:id . 54))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 185)\n  (:start . 173) (:id . 72))\n ((:tag . "JJ") (:stem . "anti-tnf") (:form . "anti-TNF") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 200)\n  (:start . 195) (:id . 74))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 211)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 220)\n  (:start . 212) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s820.6) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007652@unknown@formal@none@1@S@Furthermore, cyclosporin A, which blocked TNF alpha production induced by PKC, strongly inhibited IL-2R alpha and NF.kappa B activation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF.kappa") (:form . "NF.kappa") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s820.7) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007653@unknown@formal@none@1@S@The addition of either TNF alpha or IL-2 partially recovered cyclosporin A-induced IL-2R alpha inhibition, but only TNF alpha completely recovered NF.kappa B activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "recover") (:form . "recovered") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "a-induced") (:form . "A-induced") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "VBD") (:stem . "recover") (:form . "recovered") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "NF.kappa") (:form . "NF.kappa") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s820.8) (:did . :|7929104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5007655@unknown@formal@none@1@S@Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.@(((:tag . "NNP") (:stem . "Protease") (:form . "Protease") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 44) (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 54)\n  (:start . 45) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 64)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 106)\n  (:start . 97) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 126)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 150)\n  (:start . 141) (:id . 60))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 163)\n  (:start . 151) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s821.1) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5007657@unknown@formal@none@1@S@Transcriptional regulation is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site in the TF promoter.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 75)\n  (:start . 63) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s821.3) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007658@unknown@formal@none@1@S@Nuclear translocation of cytosolic c-Rel/p65 heterodimers and other members of the NF-kappa B/Rel family requires dissociation and proteolytic degradation of the inhibitor protein, I kappa B alpha.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 57)\n  (:start . 45) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 75)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 126)\n  (:start . 114) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 142)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 154)\n  (:start . 143) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 171)\n  (:start . 162) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 179)\n  (:start . 172) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 65))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 182) (:start . 181)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 188)\n  (:start . 183) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 190) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 196)\n  (:start . 191) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s821.4) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007660@unknown@formal@none@1@S@To determine if TPCK and TLCK inhibited LPS induction of TF expression, freshly isolated human monocytes and monocytic THP-1 cells were pretreated with these inhibitors for 30 min before LPS stimulation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TLCK") (:form . "TLCK") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 186)\n  (:start . 180) (:id . 71))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 202)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x821.6.1) (:span 13 15)))\n (:hscopes ((:id . :x821.6.1) (:span 13 70)))\n (:identifiers (:sid . :s821.6) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007661@unknown@formal@none@1@S@Both TPCK and TLCK inhibited LPS induction of TF protein, TF mRNA and TF promoter activity in a dose-dependent manner.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TLCK") (:form . "TLCK") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 110) (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s821.7) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007662@unknown@formal@none@1@S@These inhibitors specifically prevented degradation of I kappa B alpha and nuclear translocation of c-Rel/p65 heterodimers.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 51)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 96) (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 122)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s821.8) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007663@unknown@formal@none@1@S@In contrast, TPCK and TLCK did not block induction of an immediate-early gene encoding the transcription factor, Egr-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TLCK") (:form . "TLCK") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 72) (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x821.9.1) (:span 31 34)))\n (:nscopes ((:id . :x821.9.1) (:span 31 118)))\n (:identifiers (:sid . :s821.9) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007664@unknown@formal@none@1@S@Taken together, these data indicated that inhibiting nuclear translocation of c-Rel/p65 heterodimers prevented LPS induction of TF gene transcription in monocytic cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 100)\n  (:start . 88) (:id . 54))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 162)\n  (:start . 153) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x821.10.1) (:span 27 41)))\n (:hscopes ((:id . :x821.10.1) (:span 27 168)))\n (:identifiers (:sid . :s821.10) (:did . :|7929355|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007665@unknown@formal@none@1@S@A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myelo-monocytic") (:form . "myelo-monocytic")\n  (:end . 69) (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 88)\n  (:start . 76) (:id . 52))\n ((:tag . "VBZ") (:stem . "process") (:form . "processes") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 123)\n  (:start . 111) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 57))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 133)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "VB") (:stem . "impair") (:form . "impair") (:end . 161)\n  (:start . 155) (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 167)\n  (:start . 162) (:id . 65))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 184) (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 190)\n  (:start . 185) (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 202)\n  (:start . 191) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 211)\n  (:start . 206) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 217)\n  (:start . 212) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x822.1.1) (:span 151 154)))\n (:hscopes ((:id . :x822.1.1) (:span 151 217)))\n (:identifiers (:sid . :s822.1) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007666@unknown@formal@none@1@S@Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "dilution") (:form . "dilution") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "RB") (:stem . "strikingly") (:form . "strikingly") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 157) (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 163)\n  (:start . 158) (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 165) (:start . 164)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 185)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s822.2) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007667@unknown@formal@none@1@S@"Plus" clones replicated the virus efficiently, whereas "minus" clones did not.@(((:tag . "NNP") (:stem . "\\"Plus") (:form . "\\"Plus") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "replicate") (:form . "replicated") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "\\"minus") (:form . "\\"minus") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x822.3.1) (:span 75 78)))\n (:nscopes ((:id . :x822.3.1) (:span 75 78)))\n (:identifiers (:sid . :s822.3) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007668@unknown@formal@none@1@S@We examined these clones for differences in nuclear factor (NF)-kappa B activity which might account for the observed phenomenon.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x822.4.1) (:span 87 92)))\n (:hscopes ((:id . :x822.4.1) (:span 87 128)))\n (:identifiers (:sid . :s822.4) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007670@unknown@formal@none@1@S@It is surprising that the faster-migrating complex was composed also of p50 and p65.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "surprising") (:form . "surprising") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "faster-migrating") (:form . "faster-migrating")\n  (:end . 42) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s822.6) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007671@unknown@formal@none@1@S@However, the p65 subunit was COOH-terminally truncated, as shown by immunoprecipitation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "cooh-terminally") (:form . "COOH-terminally")\n  (:end . 44) (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 87) (:start . 68) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s822.7) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007672@unknown@formal@none@1@S@The truncation resulted from limited proteolysis of p65 during cellular extraction which released particular lysosomal serine proteases, such as elastase, cathepsin G, and proteinase 3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "truncation") (:form . "truncation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "extraction") (:form . "extraction") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "release") (:form . "released") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 118)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "elastase") (:form . "elastase") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 164)\n  (:start . 155) (:id . 64))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "proteinase") (:form . "proteinase") (:end . 182)\n  (:start . 172) (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s822.8) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007673@unknown@formal@none@1@S@These specific proteases are coordinately expressed and were present exclusively in the minus U937 clones, but not in the plus clones, as demonstrated in the case of cathepsin G.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "minus") (:form . "minus") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "plus") (:form . "plus") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 150)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 175)\n  (:start . 166) (:id . 71))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x822.9.1) (:span 111 114)))\n (:nscopes ((:id . :x822.9.1) (:span 111 133)))\n (:identifiers (:sid . :s822.9) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007674@unknown@formal@none@1@S@In addition, these proteases were detected in certain subclones of THP-1 and HL-60 cells and in primary monocytes, in each case correlating with the truncated from of p65.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "correlate") (:form . "correlating") (:end . 139)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s822.10) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007675@unknown@formal@none@1@S@We demonstrate in vitro cleavage of p65 by purified elastase and cathepsin G.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "elastase") (:form . "elastase") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s822.11) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007676@unknown@formal@none@1@S@It is possible that particular serine proteases may have inhibiting effects on the replication of HIV-1 in myelo-monocytic cells.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "myelo-monocytic") (:form . "myelo-monocytic")\n  (:end . 122) (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x822.12.1) (:span 48 51)) ((:id . :x822.12.2) (:span 6 14)))\n (:hscopes ((:id . :x822.12.1) (:span 48 128))\n  ((:id . :x822.12.2) (:span 6 128)))\n (:identifiers (:sid . :s822.12) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007677@unknown@formal@none@1@S@The data also demonstrate that special precautions must be taken when making extracts from myelo-monocytic cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "special") (:form . "special") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "precaution") (:form . "precautions") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 76) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "myelo-monocytic") (:form . "myelo-monocytic")\n  (:end . 106) (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s822.13) (:did . :|7931077|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007678@unknown@formal@none@1@S@Arrested development: understanding v-abl.@(((:tag . "VBN") (:stem . "arrest") (:form . "Arrested") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "understand") (:form . "understanding") (:end . 35)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-abl") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s823.1) (:did . :|7945272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007680@unknown@formal@none@1@S@Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre-B cell stage.@(((:tag . "NN") (:stem . "transformation") (:form . "Transformation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Abelson") (:form . "Abelson") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "VBN") (:stem . "arrest") (:form . "arrested") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s823.3) (:did . :|7945272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007681@unknown@formal@none@1@S@Recent reports have characterized these cells expressing high v-abl kinase activity as deficient in detectable NF-kappaB DNA binding activity and low level RAG gene expression.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-abl") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 155)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "rag") (:form . "RAG") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s823.4) (:did . :|7945272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007682@unknown@formal@none@1@S@These observations suggest that v-abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-abl") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x823.5.1) (:span 38 41)) ((:id . :x823.5.2) (:span 19 26)))\n (:hscopes ((:id . :x823.5.1) (:span 38 151))\n  ((:id . :x823.5.2) (:span 19 151)))\n (:identifiers (:sid . :s823.5) (:did . :|7945272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007683@unknown@formal@none@1@S@Distinct DNase-I hypersensitive sites are associated with TAL-1 transcription in erythroid and T-cell lines.@(((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DNase-I") (:form . "DNase-I") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 31) (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 37) (:start . 32)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tal-1") (:form . "TAL-1") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 101)\n  (:start . 95) (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s824.1) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007684@unknown@formal@none@1@S@The tal-1 gene, frequently activated in human T-cell acute lymphoblastic leukemia (T-ALL), is expressed in the erythroid, megakaryocytic, and mast cell lineages during normal hematopoiesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 136) (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 160)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 174)\n  (:start . 168) (:id . 71))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 188) (:start . 175) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s824.2) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007685@unknown@formal@none@1@S@To gain further insight into the molecular mechanisms that control tal-1 expression, we investigated tal-1 chromatin structure in erythroid/megakaryocytic cell lines and in T-cell lines either with or without tal-1 rearrangements.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 100)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid/megakaryocytic")\n  (:form . "erythroid/megakaryocytic") (:end . 154) (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 159) (:start . 155)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 165)\n  (:start . 160) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 179)\n  (:start . 173) (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 185)\n  (:start . 180) (:id . 67))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 192)\n  (:start . 186) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 197) (:start . 193)\n  (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 208)\n  (:start . 201) (:id . 71))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 214)\n  (:start . 209) (:id . 72))\n ((:tag . "NNS") (:stem . "rearrangement") (:form . "rearrangements")\n  (:end . 229) (:start . 215) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x824.3.1) (:span 201 208)))\n (:nscopes ((:id . :x824.3.1) (:span 201 229)))\n (:identifiers (:sid . :s824.3) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007686@unknown@formal@none@1@S@Tal-1 transcription was shown to be monoallelic in Jurkat, a T-cell line that expresses tal-1 in the absence of apparent genomic alteration of the locus.@(((:tag . "NN") (:stem . "tal-1") (:form . "Tal-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monoallelic") (:form . "monoallelic") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x824.4.1) (:span 101 108)))\n (:nscopes ((:id . :x824.4.1) (:span 101 152)))\n (:identifiers (:sid . :s824.4) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007687@unknown@formal@none@1@S@Methylation studies indicated that the tal-15' GC-rich region behaves like a CpG island, hypomethylated in normal cells, and methylated de novo on transcriptionally inactive alleles in established cell lines.@(((:tag . "NN") (:stem . "methylation") (:form . "Methylation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tal-15") (:form . "tal-15") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "gc-rich") (:form . "GC-rich") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "VBZ") (:stem . "behave") (:form . "behaves") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CpG") (:form . "CpG") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "hypomethylate") (:form . "hypomethylated")\n  (:end . 103) (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "methylate") (:form . "methylated") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 164) (:start . 147) (:id . 67))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "established") (:form . "established") (:end . 196)\n  (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 207)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x824.5.1) (:span 20 34)))\n (:hscopes ((:id . :x824.5.1) (:span 20 207)))\n (:identifiers (:sid . :s824.5) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007688@unknown@formal@none@1@S@Five major DNase-I hypersensitive sites (HS) were mapped in the tal-1 locus.@(((:tag . "CD") (:stem . "five") (:form . "Five") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNase-I") (:form . "DNase-I") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 33) (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 56) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s824.6) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007690@unknown@formal@none@1@S@HS II was weak in hematopoietic cell lines, absent in Hela, and greatly enhanced in Jurkat, suggesting that this region might be implicated in the cis-activation of tal-1 promoter 1b in this cell line.@(((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 31) (:start . 18) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Hela") (:form . "Hela") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 71)\n  (:start . 64) (:id . 56))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 80)\n  (:start . 72) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 90)\n  (:start . 84) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 102)\n  (:start . 92) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 119)\n  (:start . 113) (:id . 64))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 125)\n  (:start . 120) (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 139)\n  (:start . 129) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cis-activation") (:form . "cis-activation")\n  (:end . 161) (:start . 147) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 170)\n  (:start . 165) (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 179)\n  (:start . 171) (:id . 73))\n ((:tag . "NN") (:stem . "1b") (:form . "1b") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 195) (:start . 191)\n  (:id . 77))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 200) (:start . 196)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x824.8.1) (:span 120 125))\n  ((:id . :x824.8.2) (:span 92 102)))\n (:ncues ((:id . :x824.8.3) (:span 44 50)))\n (:hscopes ((:id . :x824.8.1) (:span 108 200))\n  ((:id . :x824.8.2) (:span 92 200)))\n (:nscopes ((:id . :x824.8.3) (:span 44 58)))\n (:identifiers (:sid . :s824.8) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007691@unknown@formal@none@1@S@HS III was weak in HEL and Jurkat, and greatly enhanced in DU528, a T-cell line that bears a t (1;14) and initiates tal-1 transcription within exon 4.@(((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HEL") (:form . "HEL") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 33)\n  (:start . 27) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 46)\n  (:start . 39) (:id . 52))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 55)\n  (:start . 47) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "du528") (:form . "DU528") (:end . 64) (:start . 59)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 74)\n  (:start . 68) (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 79) (:start . 75)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "bear") (:form . "bears") (:end . 90) (:start . 85)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "t") (:end . 94) (:start . 93)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1;14") (:form . "1;14") (:end . 100) (:start . 96)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 115)\n  (:start . 106) (:id . 68))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 121)\n  (:start . 116) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 70))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 142)\n  (:start . 136) (:id . 71))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 147) (:start . 143)\n  (:id . 72))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 149) (:start . 148)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s824.9) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007692@unknown@formal@none@1@S@These results suggest that distinct regulatory elements are associated with the use of the different tal-1 promoters.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "tal-1") (:form . "tal-1") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x824.10.1) (:span 14 21)))\n (:hscopes ((:id . :x824.10.1) (:span 14 116)))\n (:identifiers (:sid . :s824.10) (:did . :|7949138|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007693@unknown@formal@none@1@S@Functions of glutathione and glutathione disulfide in immunology and immunopathology.@(((:tag . "NNS") (:stem . "function") (:form . "Functions") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "immunology") (:form . "immunology") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunopathology") (:form . "immunopathology")\n  (:end . 84) (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s825.1) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007694@unknown@formal@none@1@S@Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of lymphocytes in vitro.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "moderate") (:form . "moderate") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "supply") (:form . "supply") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "elevate") (:form . "elevates") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 95)\n  (:start . 84) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 157)\n  (:start . 146) (:id . 66))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 171) (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 196)\n  (:start . 185) (:id . 70))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 205)\n  (:start . 200) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s825.2) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007695@unknown@formal@none@1@S@At low GSSG levels, T cells cannot optimally activate the immunologically important transcription factor NF kappa B, whereas high GSSG levels inhibit the DNA binding activity of NF kappa B.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "RB") (:stem . "optimally") (:form . "optimally") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "immunologically") (:form . "immunologically")\n  (:end . 73) (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 180) (:start . 178)\n  (:id . 71))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x825.3.1) (:span 28 34)))\n (:nscopes ((:id . :x825.3.1) (:span 28 115)))\n (:identifiers (:sid . :s825.3) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007696@unknown@formal@none@1@S@The effects of GSSG are antagonized by reduced thioredoxin (TRX).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "antagonize") (:form . "antagonized") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "thioredoxin") (:form . "thioredoxin") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TRX") (:form . "TRX") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s825.4) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007697@unknown@formal@none@1@S@As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x825.5.1) (:span 121 127)))\n (:hscopes ((:id . :x825.5.1) (:span 121 151)))\n (:identifiers (:sid . :s825.5) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007698@unknown@formal@none@1@S@These redox-regulated enzymes trigger signal cascades for NF kappa B activation and transduce signals from the T cell antigen receptor, from CD4 and CD8 molecules, and from the IL-2 receptor beta-chain.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "redox-regulated") (:form . "redox-regulated")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "VBP") (:stem . "trigger") (:form . "trigger") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 44)\n  (:start . 38) (:id . 46))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 162)\n  (:start . 153) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 181) (:start . 177)\n  (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 190)\n  (:start . 182) (:id . 73))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 201)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s825.6) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007700@unknown@formal@none@1@S@As signal transduction is facilitated by prooxidant conditions, we propose that the well-known immunological consequences of GSH depletion ultimately may be results of the accompanying GSSG deficiency.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "facilitate") (:form . "facilitated") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "prooxidant") (:form . "prooxidant") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "well-known") (:form . "well-known") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 121)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 149)\n  (:start . 139) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "accompany") (:form . "accompanying") (:end . 184)\n  (:start . 172) (:id . 67))\n ((:tag . "NN") (:stem . "gssg") (:form . "GSSG") (:end . 189) (:start . 185)\n  (:id . 68))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 200)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x825.8.1) (:span 150 153))\n  ((:id . :x825.8.2) (:span 67 74)))\n (:hscopes ((:id . :x825.8.1) (:span 150 200))\n  ((:id . :x825.8.2) (:span 67 200)))\n (:identifiers (:sid . :s825.8) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007701@unknown@formal@none@1@S@As HIV-infected patients and SIV-infected rhesus macaques have, on the average, significantly decreased plasma cyst(e)ine and intracellular GSH levels, we also hypothesize that AIDS may be the consequence of a GSSG deficiency as well.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "siv-infected") (:form . "SIV-infected") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "rhesus") (:form . "rhesus") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "macaque") (:form . "macaques") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "cyst(e)ine") (:form . "cyst(e)ine") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 139) (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "gsh") (:form . "GSH") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 150)\n  (:start . 144) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "hypothesize") (:form . "hypothesize") (:end . 171)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 188) (:start . 186)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 204)\n  (:start . 193) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GSSG") (:form . "GSSG") (:end . 214) (:start . 210)\n  (:id . 75))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 225)\n  (:start . 215) (:id . 76))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 233) (:start . 229)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x825.9.1) (:span 182 185))\n  ((:id . :x825.9.2) (:span 160 171)))\n (:hscopes ((:id . :x825.9.1) (:span 182 233))\n  ((:id . :x825.9.2) (:span 160 233)))\n (:identifiers (:sid . :s825.9) (:did . :|7958618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007702@unknown@formal@none@1@S@Erythropoietin-dependent induction of hemoglobin synthesis in a cytokine-dependent cell line M-TAT.@(((:tag . "JJ") (:stem . "erythropoietin-dependent")\n  (:form . "Erythropoietin-dependent") (:end . 24) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 34)\n  (:start . 25) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 48)\n  (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 58)\n  (:start . 49) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cytokine-dependent") (:form . "cytokine-dependent")\n  (:end . 82) (:start . 64) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 92) (:start . 88)\n  (:id . 51))\n ((:tag . "NN") (:stem . "m-tat") (:form . "M-TAT") (:end . 98) (:start . 93)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s826.1) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007703@unknown@formal@none@1@S@M-TAT is a cytokine-dependent cell line with the potential to differentiate along the erythroid and megakaryocytic lineages.@(((:tag . "NN") (:stem . "m-tat") (:form . "M-TAT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytokine-dependent") (:form . "cytokine-dependent")\n  (:end . 29) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 114) (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s826.2) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007704@unknown@formal@none@1@S@We cultured M-TAT cells long term (> 1 year) in the continuous presence of erythropoietin (EPO), granulocyte-macrophage colony-stimulating factor (GM-CSF), or stem cell factor (SCF).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "culture") (:form . "cultured") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "m-tat") (:form . "M-TAT") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "year") (:form . "year") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 62)\n  (:start . 52) (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 71)\n  (:start . 63) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 89) (:start . 75) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 119) (:start . 97) (:id . 63))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 138) (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 153)\n  (:start . 147) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 175)\n  (:start . 169) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "SCF") (:form . "SCF") (:end . 180) (:start . 177)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s826.3) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007705@unknown@formal@none@1@S@These long term cultures are referred to as M-TAT/EPO, M-TAT/GM-CSF, and M-TAT/SCF cells, respectively.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "M-TAT/EPO") (:form . "M-TAT/EPO") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "M-TAT/GM-CSF") (:form . "M-TAT/GM-CSF") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "M-TAT/SCF") (:form . "M-TAT/SCF") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 102)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s826.4) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007706@unknown@formal@none@1@S@Hemoglobin concentration and gamma-globin and erythroid delta-aminolevulinate synthase mRNA levels were significantly higher in M-TAT/EPO cells than in M-TAT/GM-CSF cells.@(((:tag . "NN") (:stem . "hemoglobin") (:form . "Hemoglobin") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 24) (:start . 11) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "JJ") (:stem . "delta-aminolevulinate")\n  (:form . "delta-aminolevulinate") (:end . 77) (:start . 56) (:id . 48))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 86)\n  (:start . 78) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 91) (:start . 87)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 98)\n  (:start . 92) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 103) (:start . 99)\n  (:id . 52))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 117) (:start . 104) (:id . 53))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 124)\n  (:start . 118) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "M-TAT/EPO") (:form . "M-TAT/EPO") (:end . 137)\n  (:start . 128) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 148) (:start . 144)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "M-TAT/GM-CSF") (:form . "M-TAT/GM-CSF")\n  (:end . 164) (:start . 152) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s826.5) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007707@unknown@formal@none@1@S@When the supplemented cytokine was switched from GM-CSF to EPO, hemoglobin synthesis in M-TAT/GM-CSF cells increased rapidly (within 5 h), and the level of GATA-1 mRNA increased.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "supplement") (:form . "supplemented") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "switch") (:form . "switched") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "M-TAT/GM-CSF") (:form . "M-TAT/GM-CSF")\n  (:end . 100) (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GATA-1") (:form . "GATA-1") (:end . 162)\n  (:start . 156) (:id . 70))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 177)\n  (:start . 168) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s826.6) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007708@unknown@formal@none@1@S@In contrast, the addition of GM-CSF to the M-TAT/EPO cell culture decreased the amount of hemoglobin, even in the presence of EPO, indicating that the EPO signal for erythroid differentiation is suppressed by GM-CSF.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M-TAT/EPO") (:form . "M-TAT/EPO") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 141)\n  (:start . 131) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 161)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 175)\n  (:start . 166) (:id . 73))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 191) (:start . 176) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 194) (:start . 192)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 205)\n  (:start . 195) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 208) (:start . 206)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 215)\n  (:start . 209) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x826.7.1) (:span 131 146)))\n (:hscopes ((:id . :x826.7.1) (:span 131 215)))\n (:identifiers (:sid . :s826.7) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007710@unknown@formal@none@1@S@These results support the hypothesis that EPO actively influences the programming of gene expression required for erythroid progenitor cell differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "programming") (:form . "programming") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 155) (:start . 140) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x826.9.1) (:span 26 36)))\n (:hscopes ((:id . :x826.9.1) (:span 26 155)))\n (:identifiers (:sid . :s826.9) (:did . :|7961690|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007711@unknown@formal@none@1@S@One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrens' syndrome.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 25)\n  (:start . 14) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "autoantigen") (:form . "autoantigen") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "la/ss-b") (:form . "La/SS-B") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . "NNP") (:stem . "Sjogrens") (:form . "Sjogrens") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s827.1) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007712@unknown@formal@none@1@S@A cDNA library was prepared from peripheral blood lymphocytes of an autoimmune patient with primary Sjogrens' syndrome.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NNP") (:stem . "Sjogrens") (:form . "Sjogrens") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s827.2) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007713@unknown@formal@none@1@S@The cDNA library was screened with the patients own autoimmune serum being monospecific for the nuclear autoantigen La/SS-B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "screen") (:form . "screened") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "own") (:form . "own") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monospecific") (:form . "monospecific") (:end . 87)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "autoantigen") (:form . "autoantigen") (:end . 115)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "la/ss-b") (:form . "La/SS-B") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s827.3) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007714@unknown@formal@none@1@S@Thereby an alternative type of La mRNA was identified that differed from the known La mRNA due to an exchange of the exon 1.@(((:tag . "RB") (:stem . "thereby") (:form . "Thereby") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "La") (:form . "La") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "La") (:form . "La") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s827.4) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007715@unknown@formal@none@1@S@Sequencing of the genomic region between the exons 1 and 2 showed that the alternative 5'-end is a part of the intron.@(((:tag . "NN") (:stem . "sequencing") (:form . "Sequencing") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 65) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 86)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "5'-end") (:form . "5'-end") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 117)\n  (:start . 111) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s827.5) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007716@unknown@formal@none@1@S@In addition, the presence of an alternative promoter site, which exists within the intron downstream of the exon 1, became evident.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 43)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "become") (:form . "became") (:end . 122)\n  (:start . 116) (:id . 64))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s827.6) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007717@unknown@formal@none@1@S@In consequence, the alternative La mRNA is the result of a promoter switching combined with an alternative splicing mechanism.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "La") (:form . "La") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s827.7) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007718@unknown@formal@none@1@S@In the intron, further transcription factor binding sites, including a NF-kappa B element, were identified leading to the suggestion that the expression of the gene encoding for the nuclear autoantigen La/SS-B alters in dependence on disease conditions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "suggestion") (:form . "suggestion") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 189)\n  (:start . 182) (:id . 73))\n ((:tag . "NN") (:stem . "autoantigen") (:form . "autoantigen") (:end . 201)\n  (:start . 190) (:id . 74))\n ((:tag . "NN") (:stem . "la/ss-b") (:form . "La/SS-B") (:end . 209)\n  (:start . 202) (:id . 75))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 216)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 230)\n  (:start . 220) (:id . 78))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 233) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 241)\n  (:start . 234) (:id . 80))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 252)\n  (:start . 242) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x827.8.1) (:span 122 132)))\n (:hscopes ((:id . :x827.8.1) (:span 122 252)))\n (:identifiers (:sid . :s827.8) (:did . :|7964483|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007720@unknown@formal@none@1@S@T cell hybridomas respond to activation signals by undergoing apoptotic cell death, and this is likely to represent comparable events related to tolerance induction in immature and mature T cells in vivo.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 187)\n  (:start . 181) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 189) (:start . 188)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 195)\n  (:start . 190) (:id . 72))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 73))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 203) (:start . 199)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x828.2.1) (:span 96 102)))\n (:hscopes ((:id . :x828.2.1) (:span 88 203)))\n (:identifiers (:sid . :s828.2) (:did . :|7964516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007721@unknown@formal@none@1@S@Previous studies using antisense oligonucleotides implicated the c-Myc protein in the phenomenon of activation-induced apoptosis.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 49) (:start . 33) (:id . 46))\n ((:tag . "VBD") (:stem . "implicate") (:form . "implicated") (:end . 60)\n  (:start . 50) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-Myc") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 118) (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 128)\n  (:start . 119) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s828.3) (:did . :|7964516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007722@unknown@formal@none@1@S@This role for c-Myc in apoptosis is now confirmed in studies using a dominant negative form of its heterodimeric binding partner, Max, which we show here inhibits activation-induced apoptosis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-Myc") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 112) (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Max") (:form . "Max") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 181) (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s828.4) (:did . :|7964516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007723@unknown@formal@none@1@S@Further, coexpression of a reciprocally mutant Myc protein capable of forming functional heterodimers with the mutant Max can compensate for the dominant negative activity and restore activation-induced apoptosis.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "reciprocally") (:form . "reciprocally") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "Myc") (:form . "Myc") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "form") (:form . "forming") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "Max") (:form . "Max") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "VB") (:stem . "compensate") (:form . "compensate") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 202) (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 212)\n  (:start . 203) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s828.5) (:did . :|7964516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007724@unknown@formal@none@1@S@These results imply that Myc promotes activation-induced apoptosis by obligatory heterodimerization with Max, and therefore, by regulating gene transcription.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Myc") (:form . "Myc") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 56) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "heterodimerization") (:form . "heterodimerization")\n  (:end . 99) (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Max") (:form . "Max") (:end . 108) (:start . 105)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 56))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x828.6.1) (:span 14 19)))\n (:hscopes ((:id . :x828.6.1) (:span 14 157)))\n (:identifiers (:sid . :s828.6) (:did . :|7964516|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007725@unknown@formal@none@1@S@DNA-binding studies of the Epstein-Barr virus nuclear antigen 2 (EBNA-2): evidence for complex formation by latent membrane protein gene promoter-binding proteins in EBNA-2-positive cell lines.@(((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "promoter-binding") (:form . "promoter-binding")\n  (:end . 153) (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ebna-2-positive") (:form . "EBNA-2-positive")\n  (:end . 181) (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 186) (:start . 182)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 192)\n  (:start . 187) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s829.1) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007726@unknown@formal@none@1@S@The Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) protein is essential for the immortalization of human primary B cells by EBV.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 63)\n  (:start . 56) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 76)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 100) (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 117)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s829.2) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007727@unknown@formal@none@1@S@EBNA-2 trans-activates cellular and viral genes like CD23, c-fgr, latent membrane protein 1 (LMP1) and terminal protein 1 (TP1).@(((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "trans-activate") (:form . "trans-activates")\n  (:end . 22) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fgr") (:form . "c-fgr") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tp1") (:form . "TP1") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s829.3) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007728@unknown@formal@none@1@S@Trans-activation of the TP1 promoter and of the BamHI C promoter has already been investigated in detail and appears to be mediated via protein-protein interactions and not by direct binding of EBNA-2 type A (of EBV type 1) to the DNA.@(((:tag . "NNP") (:stem . "Trans-activation") (:form . "Trans-activation")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tp1") (:form . "TP1") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "BamHI") (:form . "BamHI") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 94)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 151) (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 164)\n  (:start . 152) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 190)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 205) (:start . 201)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 207) (:start . 206)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 209) (:start . 208)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 215) (:start . 212)\n  (:id . 78))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 220) (:start . 216)\n  (:id . 79))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 222) (:start . 221)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 81))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 83))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 234) (:start . 231)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x829.4.2) (:span 109 116)))\n (:ncues ((:id . :x829.4.1) (:span 169 172)))\n (:hscopes ((:id . :x829.4.2) (:span 109 234)))\n (:nscopes ((:id . :x829.4.1) (:span 169 234)))\n (:identifiers (:sid . :s829.4) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007730@unknown@formal@none@1@S@Various reports have delineated the cis-acting elements of the LMP promoter through which EBNA-2 mediates trans-activation.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "delineate") (:form . "delineated") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 122) (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s829.6) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007731@unknown@formal@none@1@S@To determine whether EBNA-2 also trans-activates the LMP promoter by protein-protein interactions, we performed a series of gel retardation assays and competition experiments with LMP promoter fragments of different sizes.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "trans-activate") (:form . "trans-activates")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 84) (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 97)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 120)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 162)\n  (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 174)\n  (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 192)\n  (:start . 184) (:id . 68))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 202)\n  (:start . 193) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 215)\n  (:start . 206) (:id . 71))\n ((:tag . "NNS") (:stem . "size") (:form . "sizes") (:end . 221)\n  (:start . 216) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x829.7.1) (:span 13 20)))\n (:hscopes ((:id . :x829.7.1) (:span 13 97)))\n (:identifiers (:sid . :s829.7) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007732@unknown@formal@none@1@S@We determined that the protein-binding region on the LMP promoter was within a 42 bp fragment encompassing nucleotides -135 to -176 relative to the LMP transcriptional start site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "protein-binding") (:form . "protein-binding")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 106)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 118)\n  (:start . 107) (:id . 59))\n ((:tag . "CD") (:stem . "-135") (:form . "-135") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-176") (:form . "-176") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 167) (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s829.8) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007733@unknown@formal@none@1@S@None of the DNA fragments investigated indicated interaction of EBNA-2 with the DNA via protein-protein interactions.@(((:tag . "NN") (:stem . "none") (:form . "None") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ebna-2") (:form . "EBNA-2") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 103) (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 116)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s829.9) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007734@unknown@formal@none@1@S@No significant differences between EBNA-2-positive and EBNA-2-negative nuclear extracts could be seen in the gel retardation assay under conditions that clearly showed binding of EBNA-2A to the TP1 promoter.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "ebna-2-positive") (:form . "EBNA-2-positive")\n  (:end . 50) (:start . 35) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ebna-2-negative") (:form . "EBNA-2-negative")\n  (:end . 70) (:start . 55) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 49))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 87)\n  (:start . 79) (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 93) (:start . 88)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 101) (:start . 97)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 124)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 136)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 147)\n  (:start . 137) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 160)\n  (:start . 153) (:id . 62))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 167)\n  (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 175)\n  (:start . 168) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "EBNA-2A") (:form . "EBNA-2A") (:end . 186)\n  (:start . 179) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tp1") (:form . "TP1") (:end . 197) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 206)\n  (:start . 198) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s829.10) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007735@unknown@formal@none@1@S@However, analysis of sucrose gradient fractions in the gel retardation assay provided evidence that the LMP promoter-binding proteins form a complex of higher M(r) in EBNA-2-positive cell extracts.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sucrose") (:form . "sucrose") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "gradient") (:form . "gradient") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "provide") (:form . "provided") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "promoter-binding") (:form . "promoter-binding")\n  (:end . 124) (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "NNS") (:stem . "M(r)") (:form . "M(r)") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "ebna-2-positive") (:form . "EBNA-2-positive")\n  (:end . 182) (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 187) (:start . 183)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s829.11) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007736@unknown@formal@none@1@S@These complexes were destroyed by detergent.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "destroy") (:form . "destroyed") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "detergent") (:form . "detergent") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s829.12) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007737@unknown@formal@none@1@S@We deduce from these results that EBNA-2-positive cells might indeed contain specific complexes bound to the LMP promoter which are, however, too labile to be detected in a standard gel retardation assay.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "deduce") (:form . "deduce") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ebna-2-positive") (:form . "EBNA-2-positive")\n  (:end . 49) (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "indeed") (:form . "indeed") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LMP") (:form . "LMP") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "labile") (:form . "labile") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 197)\n  (:start . 186) (:id . 74))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 203)\n  (:start . 198) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x829.13.1) (:span 56 61)))\n (:hscopes ((:id . :x829.13.1) (:span 56 203)))\n (:identifiers (:sid . :s829.13) (:did . :|7964616|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007738@unknown@formal@none@1@S@Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.@(((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 23) (:start . 9) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 112) (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . "JJ") (:stem . "variant") (:form . "variant") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s830.1) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007740@unknown@formal@none@1@S@This study was designed to investigate the functional significance of previously described mutations in the viral long terminal repeat (LTR) and to elucidate their contribution to the unique phenotype of SIVsmmPBj14.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 157)\n  (:start . 148) (:id . 66))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 176)\n  (:start . 164) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 190)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 200)\n  (:start . 191) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 215)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s830.3) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007741@unknown@formal@none@1@S@LTR-directed transcription was measured by using luciferase reporter constructs that were transiently transfected into cultured cells.@(((:tag . "JJ") (:stem . "ltr-directed") (:form . "LTR-directed") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 79)\n  (:start . 69) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 101)\n  (:start . 90) (:id . 53))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 113)\n  (:start . 102) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 118) (:start . 114)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 127)\n  (:start . 119) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s830.4) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007742@unknown@formal@none@1@S@In a wide range of cell types, the basal transcriptional activity of the LTR from SIVsmmPBj14 was found to be 2- to 4.5-fold higher than that of an LTR from a non-acutely pathogenic strain.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 9) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 40) (:start . 35)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 56) (:start . 41) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 93)\n  (:start . 82) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "CD") (:stem . "2-") (:form . "2-") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "RB") (:stem . "4.5-fold") (:form . "4.5-fold") (:end . 124)\n  (:start . 116) (:id . 65))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 131)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 136) (:start . 132)\n  (:id . 67))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 151) (:start . 148)\n  (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 156) (:start . 152)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "non-acutely") (:form . "non-acutely") (:end . 170)\n  (:start . 159) (:id . 74))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 181)\n  (:start . 171) (:id . 75))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 188)\n  (:start . 182) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s830.5) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007743@unknown@formal@none@1@S@These LTRs differ by five point mutations and a 22-bp duplication in SIVsmmPBj14, which includes a nuclear factor kappa B (NF kappa B) site.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "LTR") (:form . "LTRs") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "22-bp") (:form . "22-bp") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "duplication") (:form . "duplication") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 139) (:start . 135)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s830.6) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007744@unknown@formal@none@1@S@Transcriptional differences between these LTRs were further enhanced by two- to threefold upon treatment of cells with phorbol ester or tumor necrosis factor alpha or by cotransfection with plasmids expressing NF kappa B subunits.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 27)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 35)\n  (:start . 28) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 41) (:start . 36)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 46) (:start . 42)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "threefold") (:form . "threefold") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 184) (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 189) (:start . 185)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 198)\n  (:start . 190) (:id . 70))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 209)\n  (:start . 199) (:id . 71))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 212) (:start . 210)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 218)\n  (:start . 213) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 220) (:start . 219)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 229)\n  (:start . 221) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s830.7) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007745@unknown@formal@none@1@S@Mutagenesis studies, and the use of a reporter construct containing an enhancerless promoter, indicate that these transcriptional effects are due principally to the 22-bp sequence duplication and the NF kappa B site contained within it.@(((:tag . "NNP") (:stem . "Mutagenesis") (:form . "Mutagenesis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "enhancerless") (:form . "enhancerless") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 129) (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "RB") (:stem . "principally") (:form . "principally") (:end . 157)\n  (:start . 146) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "22-bp") (:form . "22-bp") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 179)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "duplication") (:form . "duplication") (:end . 191)\n  (:start . 180) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 208)\n  (:start . 203) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 210) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 215) (:start . 211)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 225)\n  (:start . 216) (:id . 76))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 232)\n  (:start . 226) (:id . 77))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 235) (:start . 233)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x830.8.1) (:span 94 107)))\n (:hscopes ((:id . :x830.8.1) (:span 94 235)))\n (:identifiers (:sid . :s830.8) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007746@unknown@formal@none@1@S@Finally, infectious virus stocks that were isogenic except for the LTR were generated.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "stock") (:form . "stocks") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "isogenic") (:form . "isogenic") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s830.9) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007747@unknown@formal@none@1@S@The LTR from SIVsmmPBj14 was found to confer an increase in the kinetics of virus replication in cultured cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sivsmmpbj14") (:form . "SIVsmmPBj14") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s830.10) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007748@unknown@formal@none@1@S@Inclusion of this LTR in recombinant SIVs also resulted in a two- to threefold rise in the extent of cellular proliferation that was induced in quiescent simian peripheral blood mononuclear cells.@(((:tag . "NN") (:stem . "inclusion") (:form . "Inclusion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "siv") (:form . "SIVs") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "threefold") (:form . "threefold") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 97)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 123) (:start . 110) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 153)\n  (:start . 144) (:id . 67))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 160)\n  (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 171)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 189)\n  (:start . 178) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 195)\n  (:start . 190) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s830.11) (:did . :|7966569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007750@unknown@formal@none@1@S@Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 89) (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 129) (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . "NNP") (:stem . "PEBP2/CBF") (:form . "PEBP2/CBF") (:end . 175)\n  (:start . 166) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "AML1") (:form . "AML1") (:end . 181) (:start . 177)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s831.1) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007751@unknown@formal@none@1@S@The receptor for the macrophage colony-stimulating factor (or colony-stimulating factor 1 [CSF-1]) is expressed from different promoters in monocytic cells and placental trophoblasts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 50) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 80) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 89) (:start . 88)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "csf-1") (:form . "CSF-1") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "placental") (:form . "placental") (:end . 169)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "trophoblast") (:form . "trophoblasts") (:end . 182)\n  (:start . 170) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s831.2) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007752@unknown@formal@none@1@S@We have demonstrated that the monocyte-specific expression of the CSF-1 receptor is regulated at the level of transcription by a tissue-specific promoter whose activity is stimulated by the monocyte/B-cell-specific transcription factor PU.1 (D.-E.Zhang, C.J.Hetherington, H.-M.Chen, and D.G.Tenen, Mol.Cell. Biol.14:373-381, 1994).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monocyte-specific") (:form . "monocyte-specific")\n  (:end . 47) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . 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")") (:end . 330) (:start . 329)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 331) (:start . 330)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s831.3) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007753@unknown@formal@none@1@S@Here we report that the tissue specificity of this promoter is also mediated by sequences in a region II (bp -88 to - 59), which lies 10 bp upstream from the PU.1-binding site.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "CD") (:stem . "-88") (:form . "-88") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "-") (:form . "-") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . "CD") (:stem . "59") (:form . "59") (:end . 120) (:start . 118)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 128)\n  (:start . 123) (:id . 69))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 133) (:start . 129)\n  (:id . 70))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 136) (:start . 134)\n  (:id . 71))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 139) (:start . 137)\n  (:id . 72))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 148)\n  (:start . 140) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 153) (:start . 149)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "pu.1-binding") (:form . "PU.1-binding") (:end . 170)\n  (:start . 158) (:id . 76))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 175) (:start . 171)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s831.4) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007754@unknown@formal@none@1@S@When analyzed by DNase footprinting, region II was protected preferentially in monocytic cells.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "protect") (:form . "protected") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 75) (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s831.5) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007755@unknown@formal@none@1@S@Electrophoretic mobility shift assays confirmed that region II interacts specifically with nuclear proteins from monocytic cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 85)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 107)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 122)\n  (:start . 113) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s831.6) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007756@unknown@formal@none@1@S@Two gel shift complexes (Mono A and Mono B) were formed with separate sequence elements within this region.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 55) (:start . 49)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 69)\n  (:start . 61) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 78)\n  (:start . 70) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 94)\n  (:start . 88) (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s831.7) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007757@unknown@formal@none@1@S@Competition and supershift experiments indicate that Mono B contains a member of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family, which includes the AML1 gene product, while Mono A is a distinct complex preferentially expressed in monocytic cells.@(((:tag . "NN") (:stem . "competition") (:form . "Competition") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 38)\n  (:start . 27) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "polyomavirus") (:form . "polyomavirus") (:end . 97)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "enhancer-binding") (:form . "enhancer-binding")\n  (:end . 114) (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "JJ") (:stem . "2/core-binding") (:form . "2/core-binding")\n  (:end . 137) (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 144)\n  (:start . 138) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PEBP2/CBF") (:form . "PEBP2/CBF") (:end . 155)\n  (:start . 146) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 163)\n  (:start . 157) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 179)\n  (:start . 171) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 193) (:start . 189)\n  (:id . 69))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 201)\n  (:start . 194) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 71))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 208)\n  (:start . 203) (:id . 72))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 213) (:start . 209)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 215) (:start . 214)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 229)\n  (:start . 221) (:id . 77))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 237)\n  (:start . 230) (:id . 78))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 252) (:start . 238) (:id . 79))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 262)\n  (:start . 253) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 265) (:start . 263)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 275)\n  (:start . 266) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 281)\n  (:start . 276) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x831.8.1) (:span 39 52)))\n (:hscopes ((:id . :x831.8.1) (:span 39 281)))\n (:identifiers (:sid . :s831.8) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007758@unknown@formal@none@1@S@Promoter constructs with mutations in these sequence elements were no longer expressed specifically in monocytes.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "RB") (:stem . "no") (:form . "no") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "RBR") (:stem . "longer") (:form . "longer") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 99)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x831.9.1) (:span 67 76)))\n (:nscopes ((:id . :x831.9.1) (:span 0 112)))\n (:identifiers (:sid . :s831.9) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007760@unknown@formal@none@1@S@These results indicate that the monocyte/B-cell-specific transcription factor PU.1 and the Mono A and Mono B protein complexes act in concert to regulate monocyte-specific transcription of the CSF-1 receptor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monocyte/b-cell-specific")\n  (:form . "monocyte/B-cell-specific") (:end . 56) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 49))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 82) (:start . 78)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 97) (:start . 96)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "JJ") (:stem . "monocyte-specific") (:form . "monocyte-specific")\n  (:end . 171) (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 185) (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "csf-1") (:form . "CSF-1") (:end . 198)\n  (:start . 193) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 207)\n  (:start . 199) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x831.11.1) (:span 14 27)))\n (:hscopes ((:id . :x831.11.1) (:span 14 207)))\n (:identifiers (:sid . :s831.11) (:did . :|7969146|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007761@unknown@formal@none@1@S@A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 61) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DPA") (:form . "DPA") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 120)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 170) (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 186)\n  (:start . 179) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s832.1) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007762@unknown@formal@none@1@S@A novel DNA sequence element termed the J element involved in the regulated expression of class II major histocompatibility complex genes was recently described.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 123) (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s832.2) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007763@unknown@formal@none@1@S@To study this element and its role in class II gene regulation further, a cDNA library was screened with oligonucleotide probes containing both the S element and the nearby J element of the human DPA gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "screen") (:form . "screened") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 120) (:start . 105) (:id . 62))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 157)\n  (:start . 150) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nearby") (:form . "nearby") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 182)\n  (:start . 175) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 195)\n  (:start . 190) (:id . 76))\n ((:tag . "NNP") (:stem . "DPA") (:form . "DPA") (:end . 199) (:start . 196)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 204) (:start . 200)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s832.3) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007764@unknown@formal@none@1@S@Several DNA clones were obtained by this procedure, one of which, clone 18, is reported and characterized here.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 87)\n  (:start . 79) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 105) (:start . 92) (:id . 61))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s832.4) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007765@unknown@formal@none@1@S@It encodes a protein predicted to contain 688 amino acid residues, including 11 zinc finger motifs of the C2H2 type in the C-terminal region, that are Kruppel-like in the conservation of the H/C link sequence connecting them.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "CD") (:stem . "688") (:form . "688") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c2h2") (:form . "C2H2") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 133)\n  (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 140)\n  (:start . 134) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "kruppel-like") (:form . "Kruppel-like") (:end . 163)\n  (:start . 151) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 183)\n  (:start . 171) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "H/C") (:form . "H/C") (:end . 194) (:start . 191)\n  (:id . 76))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 208)\n  (:start . 200) (:id . 78))\n ((:tag . "VBG") (:stem . "connect") (:form . "connecting") (:end . 219)\n  (:start . 209) (:id . 79))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 224) (:start . 220)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s832.5) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007766@unknown@formal@none@1@S@The 160 N-terminal amino acids in the nonfinger region of clone 18 are highly homologous with similar regions of several other human, mouse, and Drosophila sequences, defining a subfamily of Kruppel-like zinc finger proteins termed TAB (tramtrack [ttk]-associated box) here.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "160") (:form . "160") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nonfinger") (:form . "nonfinger") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "define") (:form . "defining") (:end . 175)\n  (:start . 167) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 187)\n  (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "kruppel-like") (:form . "Kruppel-like") (:end . 203)\n  (:start . 191) (:id . 75))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 208) (:start . 204)\n  (:id . 76))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 215)\n  (:start . 209) (:id . 77))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 224)\n  (:start . 216) (:id . 78))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 231)\n  (:start . 225) (:id . 79))\n ((:tag . "NNP") (:stem . "TAB") (:form . "TAB") (:end . 235) (:start . 232)\n  (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 81))\n ((:tag . "NN") (:stem . "tramtrack") (:form . "tramtrack") (:end . 246)\n  (:start . 237) (:id . 82))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 248) (:start . 247)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "ttk]-associated") (:form . "ttk]-associated")\n  (:end . 263) (:start . 248) (:id . 84))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 267) (:start . 264)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 268) (:start . 267)\n  (:id . 86))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 273) (:start . 269)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s832.6) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007767@unknown@formal@none@1@S@One of the Drosophila sequences, ttk, is a developmental control gene, while a second does not contain a zinc finger region but encodes a structure important in oocyte development.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ttk") (:form . "ttk") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 56) (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 85)\n  (:start . 79) (:id . 58))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 102)\n  (:start . 95) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 109) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 116)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 123)\n  (:start . 117) (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 135)\n  (:start . 128) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 68))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 147)\n  (:start . 138) (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 157)\n  (:start . 148) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "NN") (:stem . "oocyte") (:form . "oocyte") (:end . 167)\n  (:start . 161) (:id . 72))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 179)\n  (:start . 168) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x832.7.1) (:span 91 94)))\n (:nscopes ((:id . :x832.7.1) (:span 91 123)))\n (:identifiers (:sid . :s832.7) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007768@unknown@formal@none@1@S@An acidic activation domain is located between the N-terminal conserved region of clone 18 and its zinc fingers.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s832.8) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007770@unknown@formal@none@1@S@Antisense cDNA to clone 18 inhibited the expression of a reporter construct containing the DPA promoter, indicating its functional importance in the expression of this class II gene.@(((:tag . "JJ") (:stem . "antisense") (:form . "Antisense") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DPA") (:form . "DPA") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s832.10) (:did . :|7969177|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007771@unknown@formal@none@1@S@Glucocorticoid-induced apoptosis of lymphoid cells.@(((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "Glucocorticoid-induced") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 32)\n  (:start . 23) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 44)\n  (:start . 36) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s833.1) (:did . :|7981603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007772@unknown@formal@none@1@S@The induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 64) (:start . 49) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thoroughly") (:form . "thoroughly") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s833.2) (:did . :|7981603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007773@unknown@formal@none@1@S@Although the exact mechanism by which apoptosis occurs in lymphocytes is unknown many biochemical and molecular changes have been shown to occur in these cells in response to glucocorticoids.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 190) (:start . 175) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x833.3.1) (:span 73 80)))\n (:hscopes ((:id . :x833.3.1) (:span 9 80)))\n (:identifiers (:sid . :s833.3) (:did . :|7981603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007774@unknown@formal@none@1@S@The role of chromatin degradation and endonucleases in the apoptotic process has been closely studied, as well as the involvement of several oncogenes in glucocorticoid-induced cell lysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "endonucleas") (:form . "endonucleases") (:end . 51)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 129)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 140)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "oncogene") (:form . "oncogenes") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "glucocorticoid-induced") (:end . 176) (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "lysis") (:form . "lysis") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s833.4) (:did . :|7981603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007775@unknown@formal@none@1@S@In addition, the clinical importance of glucocorticoid-induced apoptosis in the treatment of lymphoid neoplasms has recently received increased attention.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "glucocorticoid-induced") (:end . 62) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "neoplasm") (:form . "neoplasms") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "VBN") (:stem . "receive") (:form . "received") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 143)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "attention") (:form . "attention") (:end . 153)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s833.5) (:did . :|7981603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007776@unknown@formal@none@1@S@Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 36) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tat-activated") (:form . "Tat-activated")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 155) (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 161)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 166) (:start . 162)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "1-infected") (:form . "1-infected") (:end . 177)\n  (:start . 167) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s834.1) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007777@unknown@formal@none@1@S@We have examined the feasibility of using interferon (IFN) gene transfer as a novel approach to anti-human immunodeficiency virus type 1 (HIV-1) therapy in this study.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "feasibility") (:form . "feasibility") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-human") (:form . "anti-human") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 123) (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s834.2) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5007780@unknown@formal@none@1@S@Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 (ISG15), containing the IFN-stimulated response element, partially restored Tat-mediated activation of LTR in T cells as well as in monocytes.@(((:tag . "NN") (:stem . "replacement") (:form . "Replacement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . 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5007781@unknown@formal@none@1@S@Insertion of this chimeric promoter (ISG15 LTR) upstream of the human IFNA2 gene directed high levels of IFN synthesis in Tat-expressing cells, while this promoter was not responsive to tumor necrosis factor alpha-mediated activation.@(((:tag . "NNP") (:stem . "Insertion") (:form . "Insertion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ISG15") (:form . "ISG15") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ifna2") (:form . "IFNA2") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "direct") (:form . "directed") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "tat-expressing") (:form . "Tat-expressing")\n  (:end . 136) (:start . 122) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 182)\n  (:start . 172) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 191)\n  (:start . 186) (:id . 74))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 200)\n  (:start . 192) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . "JJ") (:stem . "alpha-mediated") (:form . "alpha-mediated")\n  (:end . 222) (:start . 208) (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 233)\n  (:start . 223) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x834.6.1) (:span 168 171)))\n (:nscopes ((:id . :x834.6.1) (:span 168 233)))\n (:identifiers (:sid . :s834.6) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007782@unknown@formal@none@1@S@ISG15-LTR-IFN hybrid gene inserted into the retrovirus vector was transduced into Jurkat and U937 cells.@(((:tag . "NN") (:stem . "isg15-ltr-ifn") (:form . "ISG15-LTR-IFN")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "retrovirus") (:form . "retrovirus") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s834.7) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007783@unknown@formal@none@1@S@Selected transfected clones produced low levels of IFN A (IFNA) constitutively, and their abilities to express interleukin-2 and interleukin-2 receptor upon stimulation with phytohemagglutinin and phorbol myristate acetate were retained.@(((:tag . "VBN") (:stem . "select") (:form . "Selected") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFNA") (:form . "IFNA") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 78) (:start . 64) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 89)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "ability") (:form . "abilities") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 124) (:start . 111) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 142) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 168)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 192) (:start . 174) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 69))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 204)\n  (:start . 197) (:id . 70))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 214)\n  (:start . 205) (:id . 71))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 222)\n  (:start . 215) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 227) (:start . 223)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 236)\n  (:start . 228) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s834.8) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007784@unknown@formal@none@1@S@Enhancement of IFNA synthesis observed upon HIV-1 infection resulted in significant inhibition of HIV-1 replication for a period of at least 30 days.@(((:tag . "NN") (:stem . "enhancement") (:form . "Enhancement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFNA") (:form . "IFNA") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 83)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 103)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 115)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s834.9) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007785@unknown@formal@none@1@S@Virus isolated from IFNA-producing cells was able to replicate in the U937 cells but did not replicate efficiently in U937 cells transduced with the IFNA gene.@(((:tag . "NN") (:stem . "virus") (:form . "Virus") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ifna-producing") (:form . "IFNA-producing")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IFNA") (:form . "IFNA") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x834.10.1) (:span 89 92)))\n (:nscopes ((:id . :x834.10.1) (:span 89 158)))\n (:identifiers (:sid . :s834.10) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007786@unknown@formal@none@1@S@These results suggest that targeting IFN synthesis to HIV-1-infected cells is an attainable goal and that autocrine IFN synthesis results in a long-lasting and permanent suppression of HIV-1 replication.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "target") (:form . "targeting") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 68) (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "attainable") (:form . "attainable") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "goal") (:form . "goal") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "long-lasting") (:form . "long-lasting") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 181)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 190)\n  (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 202)\n  (:start . 191) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x834.11.1) (:span 14 21)))\n (:hscopes ((:id . :x834.11.1) (:span 14 202)))\n (:identifiers (:sid . :s834.11) (:did . :|7983701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007787@unknown@formal@none@1@S@Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.@(((:tag . "NNP") (:stem . "Pyrrolidine") (:form . "Pyrrolidine") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 140) (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 176)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s835.1) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007788@unknown@formal@none@1@S@We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 155)\n  (:start . 146) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 168)\n  (:start . 159) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 191)\n  (:start . 185) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s835.2) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007790@unknown@formal@none@1@S@The simultaneous addition of 50-500 microM PDTC with these agents blocked NF-kappa B activation and completely abrogated both morphologically apoptotic changes and internucleosomal DNA fragmentation for up to 6 hr.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "CD") (:stem . "50-500") (:form . "50-500") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "RB") (:stem . "morphologically") (:form . "morphologically")\n  (:end . 141) (:start . 126) (:id . 60))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 159)\n  (:start . 152) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "internucleosomal") (:form . "internucleosomal")\n  (:end . 180) (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 184) (:start . 181)\n  (:id . 65))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 198) (:start . 185) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 202) (:start . 199)\n  (:id . 67))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 205) (:start . 203)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 69))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 210) (:start . 209)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 213) (:start . 211)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s835.4) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007791@unknown@formal@none@1@S@However, PDTC failed to inhibit the endonuclease activity contained in the whole cell lysates.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 20) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "endonuclease") (:form . "endonuclease") (:end . 48)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x835.5.1) (:span 14 20)))\n (:nscopes ((:id . :x835.5.1) (:span 14 93)))\n (:identifiers (:sid . :s835.5) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007792@unknown@formal@none@1@S@The inhibitory effect of PDTC was also observed in etoposide- and dexamethasone-induced apoptosis in human thymocytes at a concentration of 1-10 microM.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "etoposide-") (:form . "etoposide-") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dexamethasone-induced")\n  (:form . "dexamethasone-induced") (:end . 87) (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1-10") (:form . "1-10") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 151)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s835.6) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007793@unknown@formal@none@1@S@Since PDTC has both antioxidant and metal-ion chelating activities, we tested the effects of N-acetyl-L-cysteine (NAC) (antioxidant) or o-phenanthroline (OP) (metal-ion chelator) on the induction of apoptosis.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "metal-ion") (:form . "metal-ion") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "VBG") (:stem . "chelate") (:form . "chelating") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 77) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 112) (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "o-phenanthroline") (:form . "o-phenanthroline")\n  (:end . 152) (:start . 136) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "OP") (:form . "OP") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "metal-ion") (:form . "metal-ion") (:end . 168)\n  (:start . 159) (:id . 70))\n ((:tag . "NN") (:stem . "chelator") (:form . "chelator") (:end . 177)\n  (:start . 169) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 195)\n  (:start . 186) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 76))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 208)\n  (:start . 199) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s835.7) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007794@unknown@formal@none@1@S@Pretreatment of HL-60 cells or thymocytes with 100-500 microM OP for 2 hr, but not 10-60 mM NAC, suppressed subsequent occurrence of apoptosis induced by etoposide.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "CD") (:stem . "100-500") (:form . "100-500") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NNP") (:stem . "OP") (:form . "OP") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "CD") (:stem . "10-60") (:form . "10-60") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 107)\n  (:start . 97) (:id . 62))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 118)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 150)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 163)\n  (:start . 154) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x835.8.1) (:span 79 82)))\n (:nscopes ((:id . :x835.8.1) (:span 79 95)))\n (:identifiers (:sid . :s835.8) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007795@unknown@formal@none@1@S@These results suggest that the activation of NF-kappa B plays an important role in the apoptotic process of human hematopoietic cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 127) (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x835.9.1) (:span 14 21)))\n (:hscopes ((:id . :x835.9.1) (:span 14 133)))\n (:identifiers (:sid . :s835.9) (:did . :|7986199|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007796@unknown@formal@none@1@S@Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 42) (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 48) (:start . 43)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s836.1) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007797@unknown@formal@none@1@S@The T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "accessory") (:form . "accessory") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "apc") (:form . "APCs") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "play") (:form . "playing") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 113) (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "ag") (:form . "Ags") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s836.2) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007798@unknown@formal@none@1@S@Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s836.3) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007800@unknown@formal@none@1@S@In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 43) (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD5") (:form . "CD5") (:end . 69) (:start . 66)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lfa-1") (:form . "LFA-1") (:end . 76) (:start . 71)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 80) (:start . 78)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd7") (:form . "CD7") (:end . 84) (:start . 81)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 91) (:start . 86)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 66))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 107)\n  (:start . 98) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 116)\n  (:start . 111) (:id . 69))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 121) (:start . 117)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 132) (:start . 128)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 140)\n  (:start . 133) (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 151)\n  (:start . 141) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 76))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 160)\n  (:start . 155) (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 171)\n  (:start . 161) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x836.5.1) (:span 57 60)))\n (:nscopes ((:id . :x836.5.1) (:span 57 84)))\n (:identifiers (:sid . :s836.5) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5007802@unknown@formal@none@1@S@Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cd28-dependent") (:form . "CD28-dependent")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x836.7.2) (:span 61 67)))\n (:ncues ((:id . :x836.7.1) (:span 57 60)))\n (:hscopes ((:id . :x836.7.2) (:span 13 113)))\n (:nscopes ((:id . :x836.7.1) (:span 13 113)))\n (:identifiers (:sid . :s836.7) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007803@unknown@formal@none@1@S@A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 119)\n  (:start . 112) (:id . 64))\n ((:tag . "JJ") (:stem . "inappropriate") (:form . "inappropriate")\n  (:end . 133) (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 162)\n  (:start . 156) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 174)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 182) (:start . 178)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 76))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 197)\n  (:start . 190) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 211)\n  (:start . 203) (:id . 80))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 221)\n  (:start . 212) (:id . 81))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 230)\n  (:start . 222) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x836.8.3) (:span 15 24)))\n (:ncues ((:id . :x836.8.1) (:span 190 197))\n  ((:id . :x836.8.2) (:span 70 77)))\n (:hscopes ((:id . :x836.8.3) (:span 0 230)))\n (:nscopes ((:id . :x836.8.1) (:span 190 230))\n  ((:id . :x836.8.2) (:span 70 106)))\n (:identifiers (:sid . :s836.8) (:did . :|7989745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007804@unknown@formal@none@1@S@Constitutive nuclear NF-kappa B in cells of the monocyte lineage.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s837.1) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007805@unknown@formal@none@1@S@In monocytes, the nuclear factor NF-kappa B has been invoked as an important transcription factor in the expression of cytokine genes, of cell-surface receptors and in the expression of human immunodeficiency virus.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "invoke") (:form . "invoked") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cell-surface") (:form . "cell-surface") (:end . 150)\n  (:start . 138) (:id . 66))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 182)\n  (:start . 172) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 191)\n  (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 208) (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 214)\n  (:start . 209) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s837.2) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007806@unknown@formal@none@1@S@In such cells, DNA binding activity of NF-kappa B can be detected without intentional stimulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "JJ") (:stem . "intentional") (:form . "intentional") (:end . 85)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x837.3.1) (:span 66 73)))\n (:nscopes ((:id . :x837.3.1) (:span 66 97)))\n (:identifiers (:sid . :s837.3) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007807@unknown@formal@none@1@S@In our studies, cells of the human monocytic line Mono Mac 6, cultured in medium containing fetal-calf serum and low levels of lipopolysaccharide (LPS), also exhibit such 'constitutive' NF-kappa B, as demonstrated by mobility-shift analysis of nuclear extracts.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 70)\n  (:start . 62) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 80)\n  (:start . 74) (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 91)\n  (:start . 81) (:id . 59))\n ((:tag . "JJ") (:stem . "fetal-calf") (:form . "fetal-calf") (:end . 102)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 145) (:start . 127) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 157) (:start . 153)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 165)\n  (:start . 158) (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "'constitutive") (:form . "'constitutive")\n  (:end . 184) (:start . 171) (:id . 74))\n ((:tag . "``") (:stem . "'") (:form . "'") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 194)\n  (:start . 186) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 78))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 200) (:start . 198)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 213)\n  (:start . 201) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 216) (:start . 214)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "mobility-shift") (:form . "mobility-shift")\n  (:end . 231) (:start . 217) (:id . 82))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 240)\n  (:start . 232) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 251)\n  (:start . 244) (:id . 85))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 260)\n  (:start . 252) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s837.4) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007808@unknown@formal@none@1@S@This nuclear NF-kappa B was still present when contaminant LPS was removed by ultrafiltration and when serum was omitted.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "contaminant") (:form . "contaminant") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ultrafiltration") (:form . "ultrafiltration")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "omit") (:form . "omitted") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s837.5) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007810@unknown@formal@none@1@S@By contrast, treatment of cells with pyrrolidine dithiocarbamate (PDTC) will only block LPS-induced NF-kappa B, but not the constitutive binding protein.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 136)\n  (:start . 124) (:id . 64))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x837.7.1) (:span 116 119)))\n (:nscopes ((:id . :x837.7.1) (:span 116 152)))\n (:identifiers (:sid . :s837.7) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007811@unknown@formal@none@1@S@Using LPS-free and serum-free conditions, constitutive NF-kappa B can be detected in different cell lines of the monocytic lineage (HL60, U937, THP-1, Mono Mac 1 and Mono Mac 6), but not in Molt 4 T cells or K562 stem cells.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lps-free") (:form . "LPS-free") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "serum-free") (:form . "serum-free") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HL60") (:form . "HL60") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "THP-1") (:form . "THP-1") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 176) (:start . 175)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 182) (:start . 179)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 186) (:start . 183)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Molt") (:form . "Molt") (:end . 194) (:start . 190)\n  (:id . 81))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 196) (:start . 195)\n  (:id . 82))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 198) (:start . 197)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 84))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 207) (:start . 205)\n  (:id . 85))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 212) (:start . 208)\n  (:id . 86))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 217) (:start . 213)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 223)\n  (:start . 218) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 89)))@@@1@48@((:ncues ((:id . :x837.8.1) (:span 183 186)))\n (:nscopes ((:id . :x837.8.1) (:span 183 223)))\n (:identifiers (:sid . :s837.8) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007812@unknown@formal@none@1@S@When ordered according to stage of maturation, the amount of constitutive NF-kappa B was not increased in more mature cell lines.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "order") (:form . "ordered") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 73)\n  (:start . 61) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x837.9.1) (:span 89 92)))\n (:nscopes ((:id . :x837.9.1) (:span 47 128)))\n (:identifiers (:sid . :s837.9) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007813@unknown@formal@none@1@S@Furthermore, when inducing differentiation in Mono Mac 6 cells, with vitamin D3, no change in constitutive or inducible NF-kappa B can be detected.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "d3") (:form . "D3") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 106)\n  (:start . 94) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x837.10.1) (:span 81 83)))\n (:nscopes ((:id . :x837.10.1) (:span 81 146)))\n (:identifiers (:sid . :s837.10) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007814@unknown@formal@none@1@S@Analysis of primary cells revealed substantial constitutive NF-kappa B-binding activity in blood monocytes, pleural macrophages and alveolar macrophages.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 59)\n  (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 106)\n  (:start . 97) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pleural") (:form . "pleural") (:end . 115)\n  (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 127)\n  (:start . 116) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 140)\n  (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 152)\n  (:start . 141) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s837.11) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007815@unknown@formal@none@1@S@The constitutive NF-kappa B appears to be functionally active, since a low level of tumour necrosis factor (TNF) transcript is detectable in monocytes, and this level can be increased by blocking transcript degradation using cycloheximide.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 137)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 150)\n  (:start . 141) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 170) (:start . 167)\n  (:id . 72))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 183)\n  (:start . 174) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 195)\n  (:start . 187) (:id . 76))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 206)\n  (:start . 196) (:id . 77))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 218)\n  (:start . 207) (:id . 78))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 224) (:start . 219)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 238) (:start . 225) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x837.12.1) (:span 28 35)))\n (:hscopes ((:id . :x837.12.1) (:span 0 61)))\n (:identifiers (:sid . :s837.12) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007816@unknown@formal@none@1@S@The level of constitutive NF-kappa B in these cells is variable and is frequently found to be lower in the more mature macrophages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 118)\n  (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 130)\n  (:start . 119) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s837.13) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007817@unknown@formal@none@1@S@Constitutive NF-kappa B was not maintained by autocrine action of cytokines TNF, interleukin 6, interleukin 10, granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor, since neutralizing antibodies did not reduce constitutive DNA-binding activity.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 134) (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 153) (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 160)\n  (:start . 154) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 174)\n  (:start . 164) (:id . 65))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 193) (:start . 175) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 200)\n  (:start . 194) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 68))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 207)\n  (:start . 202) (:id . 69))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 220)\n  (:start . 208) (:id . 70))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 231)\n  (:start . 221) (:id . 71))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 235) (:start . 232)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 239) (:start . 236)\n  (:id . 73))\n ((:tag . "VB") (:stem . "reduce") (:form . "reduce") (:end . 246)\n  (:start . 240) (:id . 74))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 259)\n  (:start . 247) (:id . 75))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 271)\n  (:start . 260) (:id . 76))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 280)\n  (:start . 272) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x837.14.1) (:span 236 239))\n  ((:id . :x837.14.2) (:span 28 31)))\n (:nscopes ((:id . :x837.14.1) (:span 236 280))\n  ((:id . :x837.14.2) (:span 0 200)))\n (:identifiers (:sid . :s837.14) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007818@unknown@formal@none@1@S@Furthermore, blockade of prostaglandin or leukotriene biosynthesis did not affect constitutive NF-kappa B.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "leukotriene") (:form . "leukotriene") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "biosynthesis") (:form . "biosynthesis") (:end . 66)\n  (:start . 54) (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 94)\n  (:start . 82) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x837.15.1) (:span 71 74)))\n (:nscopes ((:id . :x837.15.1) (:span 71 105)))\n (:identifiers (:sid . :s837.15) (:did . :|7998962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007820@unknown@formal@none@1@S@Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma.@(((:tag . "JJ") (:stem . "nonpituitary") (:form . "Nonpituitary") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "prolactin") (:form . "prolactin") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 90) (:start . 76) (:id . 52))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 116)\n  (:start . 105) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "endometrial") (:form . "endometrial") (:end . 135)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "stroma") (:form . "stroma") (:end . 142)\n  (:start . 136) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s838.1) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007821@unknown@formal@none@1@S@Expression of the human PRL (hPRL) gene in extrapituitary sites such as the uterus (decidualized endometrial stroma and myometrium) and cells of the hematopoietic lineage is directed by an alternative promoter which is located approximately 6 kilobases (kb) upstream of the pituitary-specific start site.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hprl") (:form . "hPRL") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . 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"hematopoietic")\n  (:end . 162) (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 170)\n  (:start . 163) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 182)\n  (:start . 174) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 200)\n  (:start . 189) (:id . 75))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 209)\n  (:start . 201) (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 215)\n  (:start . 210) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 218) (:start . 216)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 226)\n  (:start . 219) (:id . 79))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 240) (:start . 227) (:id . 80))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 242) (:start . 241)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 252)\n  (:start . 243) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 254) (:start . 253)\n  (:id . 83))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 256) (:start . 254)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 257) (:start . 256)\n  (:id . 85))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 266)\n  (:start . 258) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 269) (:start . 267)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 273) (:start . 270)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "pituitary-specific") (:form . "pituitary-specific")\n  (:end . 292) (:start . 274) (:id . 89))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 298)\n  (:start . 293) (:id . 90))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 303) (:start . 299)\n  (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 304) (:start . 303)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s838.2) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007822@unknown@formal@none@1@S@In order to delineate the tissue-specific mechanisms governing the control of nonpituitary PRL gene expression, we have cloned and sequenced 3 kb 5'-flanking DNA of the upstream decidual/lymphoid (dPRL) promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 41) (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "VBG") (:stem . "govern") (:form . "governing") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nonpituitary") (:form . "nonpituitary") (:end . 90)\n  (:start . 78) (:id . 53))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 157)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "JJ") (:stem . "decidual/lymphoid") (:form . "decidual/lymphoid")\n  (:end . 195) (:start . 178) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 71))\n ((:tag . "NN") (:stem . "dprl") (:form . "dPRL") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 211)\n  (:start . 203) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s838.3) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007823@unknown@formal@none@1@S@Based on sequence homology we identified two binding motifs for Pit-1 and seven half-sites for glucocorticoid receptor/progesterone receptor (PR) binding.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "half-site") (:form . "half-sites") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 109) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "receptor/progesterone")\n  (:form . "receptor/progesterone") (:end . 131) (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 140)\n  (:start . 132) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 153)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s838.4) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007824@unknown@formal@none@1@S@We focused our studies on the role of Pit-1 and of PR as potential transcriptional regulators, since the POU domain protein Pit-1 is essential in the control of pituitary PRL expression, and progesterone induces decidual transformation of the endometrial stroma, a differentiation process during which the decidual PRL gene is activated.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "focus") (:form . "focused") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 66)\n  (:start . 57) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 82) (:start . 67) (:id . 56))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 157)\n  (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 170)\n  (:start . 161) (:id . 71))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 185)\n  (:start . 175) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 75))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 203)\n  (:start . 191) (:id . 76))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 211)\n  (:start . 204) (:id . 77))\n ((:tag . "JJ") (:stem . "decidual") (:form . "decidual") (:end . 220)\n  (:start . 212) (:id . 78))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 235) (:start . 221) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 242) (:start . 239)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "endometrial") (:form . "endometrial") (:end . 254)\n  (:start . 243) (:id . 82))\n ((:tag . "NN") (:stem . "stroma") (:form . "stroma") (:end . 261)\n  (:start . 255) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 262) (:start . 261)\n  (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 264) (:start . 263)\n  (:id . 85))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 280) (:start . 265) (:id . 86))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 288)\n  (:start . 281) (:id . 87))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 295)\n  (:start . 289) (:id . 88))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 301)\n  (:start . 296) (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 305) (:start . 302)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "decidual") (:form . "decidual") (:end . 314)\n  (:start . 306) (:id . 91))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 318) (:start . 315)\n  (:id . 92))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 323) (:start . 319)\n  (:id . 93))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 326) (:start . 324)\n  (:id . 94))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 336)\n  (:start . 327) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 337) (:start . 336)\n  (:id . 96)))@@@1@55@((:hcues ((:id . :x838.5.1) (:span 57 66)))\n (:hscopes ((:id . :x838.5.1) (:span 57 93)))\n (:identifiers (:sid . :s838.5) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007825@unknown@formal@none@1@S@We demonstrate in a variety of cell types, including lymphocytes and endometrial stroma, that Pit-1 is not involved in the regulation of dPRL promoter/reporter gene constructs carrying 3 kb 5'-flanking DNA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endometrial") (:form . "endometrial") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "stroma") (:form . "stroma") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "dprl") (:form . "dPRL") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "promoter/reporter") (:form . "promoter/reporter")\n  (:end . 159) (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 175)\n  (:start . 165) (:id . 69))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 201)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x838.6.1) (:span 103 106)))\n (:nscopes ((:id . :x838.6.1) (:span 103 205)))\n (:identifiers (:sid . :s838.6) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007826@unknown@formal@none@1@S@Our experiments also show that activated PR does not confer direct transcriptional control on the dPRL promoter.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "PR") (:form . "PR") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 82) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dprl") (:form . "dPRL") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x838.7.1) (:span 49 52)))\n (:nscopes ((:id . :x838.7.1) (:span 49 111)))\n (:identifiers (:sid . :s838.7) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007827@unknown@formal@none@1@S@When we compared the activity of the transfected dPRL promoter in PRL-secreting and nonsecreting lymphoid cells, we found that the 3 kb 5'-flanking region of the dPRL promoter did not contain elements restricting expression to only those lymphocytes that produce PRL but allowed expression of fusion reporter genes irrespective of the status of the endogenous PRL gene.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "dprl") (:form . "dPRL") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "prl-secreting") (:form . "PRL-secreting")\n  (:end . 79) (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nonsecreting") (:form . "nonsecreting") (:end . 96)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . 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"NN") (:stem . "dprl") (:form . "dPRL") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 175)\n  (:start . 167) (:id . 70))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 183) (:start . 180)\n  (:id . 72))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 191)\n  (:start . 184) (:id . 73))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 200)\n  (:start . 192) (:id . 74))\n ((:tag . "VBG") (:stem . "restrict") (:form . "restricting") (:end . 212)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 223)\n  (:start . 213) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 231) (:start . 227)\n  (:id . 78))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 237)\n  (:start . 232) (:id . 79))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 249)\n  (:start . 238) (:id . 80))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 254) (:start . 250)\n  (:id . 81))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 262)\n  (:start . 255) (:id . 82))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 266) (:start . 263)\n  (:id . 83))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 270) (:start . 267)\n  (:id . 84))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 278)\n  (:start . 271) (:id . 85))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 289)\n  (:start . 279) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 292) (:start . 290)\n  (:id . 87))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 299)\n  (:start . 293) (:id . 88))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 308)\n  (:start . 300) (:id . 89))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 314)\n  (:start . 309) (:id . 90))\n ((:tag . "JJ") (:stem . "irrespective") (:form . "irrespective") (:end . 327)\n  (:start . 315) (:id . 91))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 330) (:start . 328)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 334) (:start . 331)\n  (:id . 93))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 341)\n  (:start . 335) (:id . 94))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 344) (:start . 342)\n  (:id . 95))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 348) (:start . 345)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 359)\n  (:start . 349) (:id . 97))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 363) (:start . 360)\n  (:id . 98))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 368) (:start . 364)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 369) (:start . 368)\n  (:id . 100)))@@@1@59@((:ncues ((:id . :x838.8.1) (:span 180 183)))\n (:nscopes ((:id . :x838.8.1) (:span 180 266)))\n (:identifiers (:sid . :s838.8) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007828@unknown@formal@none@1@S@This was in sharp contrast to endometrial cells where 3 kb 5'-flanking DNA conferred strong transcriptional activation on the dPRL promoter in decidualized endometrial stromal cells actively secreting PRL, but did not allow transcription in undifferentiated non-PRL-secreting endometrial stromal cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "sharp") (:form . "sharp") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endometrial") (:form . "endometrial") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 70)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 107) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dprl") (:form . "dPRL") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "decidualize") (:form . "decidualized") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "JJ") (:stem . "endometrial") (:form . "endometrial") (:end . 167)\n  (:start . 156) (:id . 65))\n ((:tag . "JJ") (:stem . "stromal") (:form . "stromal") (:end . 175)\n  (:start . 168) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 67))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 190)\n  (:start . 182) (:id . 68))\n ((:tag . "VBG") (:stem . "secrete") (:form . "secreting") (:end . 200)\n  (:start . 191) (:id . 69))\n ((:tag . "NNP") (:stem . "PRL") (:form . "PRL") (:end . 204) (:start . 201)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 209) (:start . 206)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 213) (:start . 210)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 217) (:start . 214)\n  (:id . 74))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 223)\n  (:start . 218) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 237) (:start . 224) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "undifferentiated") (:form . "undifferentiated")\n  (:end . 257) (:start . 241) (:id . 78))\n ((:tag . "JJ") (:stem . "non-prl-secreting") (:form . "non-PRL-secreting")\n  (:end . 275) (:start . 258) (:id . 79))\n ((:tag . "JJ") (:stem . "endometrial") (:form . "endometrial") (:end . 287)\n  (:start . 276) (:id . 80))\n ((:tag . "JJ") (:stem . "stromal") (:form . "stromal") (:end . 295)\n  (:start . 288) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 301)\n  (:start . 296) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x838.9.1) (:span 214 217)))\n (:nscopes ((:id . :x838.9.1) (:span 214 301)))\n (:identifiers (:sid . :s838.9) (:did . :|8015553|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007830@unknown@formal@none@1@S@Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pp90rsk") (:form . "pp90rsk") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 114) (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s839.1) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007831@unknown@formal@none@1@S@The present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression during monocytic differentiation of U-937 myeloid leukemia cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 149) (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s839.2) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007832@unknown@formal@none@1@S@Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threonine protein kinase C, was associated with transcriptional activation of EGR-1 promoter-reporter constructs.@(((:tag . "NNP") (:stem . "Differentiation") (:form . "Differentiation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 72) (:start . 36)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 77) (:start . 74)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 116) (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 131)\n  (:start . 125) (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 133) (:start . 132)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 149)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 170) (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 181)\n  (:start . 171) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 66))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 190)\n  (:start . 185) (:id . 67))\n ((:tag . "JJ") (:stem . "promoter-reporter") (:form . "promoter-reporter")\n  (:end . 208) (:start . 191) (:id . 68))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 219)\n  (:start . 209) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s839.3) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007833@unknown@formal@none@1@S@The EGR-1 promoter contains six CC(A/T)6GG (CArG) motifs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "CC(A/T)6GG") (:form . "CC(A/T)6GG") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CArG") (:form . "CArG") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s839.4) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007834@unknown@formal@none@1@S@The two 5'-most distal CArG sequences conferred TPA inducibility.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "5'-most") (:form . "5'-most") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "carg") (:form . "CArG") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s839.5) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007835@unknown@formal@none@1@S@In contrast, there was little effect of TPA on EGR-1 transcription in a TPA-resistant U-937 cell variant, designated TUR.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tpa-resistant") (:form . "TPA-resistant")\n  (:end . 85) (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "NNP") (:stem . "TUR") (:form . "TUR") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s839.6) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007836@unknown@formal@none@1@S@Treatment of both U-937 and TUR cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases 1 and 2A, was associated with induction of monocytic differentiation and EGR-1 transcription through the 5'-most CArG element.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tur") (:form . "TUR") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 89) (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 110)\n  (:start . 98) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 163)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 179) (:start . 164) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 189)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 203) (:start . 190) (:id . 72))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 211)\n  (:start . 204) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "5'-most") (:form . "5'-most") (:end . 223)\n  (:start . 216) (:id . 75))\n ((:tag . "NN") (:stem . "carg") (:form . "CArG") (:end . 228) (:start . 224)\n  (:id . 76))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 236)\n  (:start . 229) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s839.7) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007837@unknown@formal@none@1@S@Since these findings supported the involvement of serine/threonine protein phosphorylation in the regulation of EGR-1 expression, we studied activation of the 40S ribosomal protein S6 serine/threonine kinases, pp70S6K and pp90rsk.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "support") (:form . "supported") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 66) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 90) (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 108)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 117)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 128)\n  (:start . 118) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 140)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 151)\n  (:start . 141) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "40s") (:form . "40S") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ribosomal") (:form . "ribosomal") (:end . 172)\n  (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 180)\n  (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "s6") (:form . "S6") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 200) (:start . 184) (:id . 68))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 208)\n  (:start . 201) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 70))\n ((:tag . "NN") (:stem . "pp70s6k") (:form . "pp70S6K") (:end . 217)\n  (:start . 210) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 72))\n ((:tag . "NN") (:stem . "pp90rsk") (:form . "pp90rsk") (:end . 229)\n  (:start . 222) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s839.8) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007838@unknown@formal@none@1@S@Although both kinases participate in regulating cell growth, there was no detectable activation of pp70S6K during TPA- or okadaic acid-induced monocytic differentiation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pp70s6k") (:form . "pp70S6K") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "tpa-") (:form . "TPA-") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 142)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 168) (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x839.9.1) (:span 71 73)))\n (:nscopes ((:id . :x839.9.1) (:span 71 168)))\n (:identifiers (:sid . :s839.9) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007840@unknown@formal@none@1@S@In contrast, analysis of pp90rsk activity by phosphorylation of a peptide derived from S6 protein demonstrated stimulation of this kinase in TPA-treated U-937, and not TUR, cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pp90rsk") (:form . "pp90rsk") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 60) (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "S6") (:form . "S6") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 110)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "tpa-treated") (:form . "TPA-treated") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TUR") (:form . "TUR") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x839.11.1) (:span 164 167)))\n (:nscopes ((:id . :x839.11.1) (:span 164 171)))\n (:identifiers (:sid . :s839.11) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007841@unknown@formal@none@1@S@Okadaic acid treatment of both cell types was associated with activation of pp90rsk.@(((:tag . "JJ") (:stem . "okadaic") (:form . "Okadaic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pp90rsk") (:form . "pp90rsk") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s839.12) (:did . :|8018558|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007842@unknown@formal@none@1@S@Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "th0-type") (:form . "Th0-type") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s840.1) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007843@unknown@formal@none@1@S@The effects of prostaglandin E2 (PGE2) on cytokine production and proliferation of the CD4+ human helper T cell clone SP-B21 were investigated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "prostaglandin") (:form . "prostaglandin")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "sp-b21") (:form . "SP-B21") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 142)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s840.2) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007844@unknown@formal@none@1@S@In cells stimulated with anti-CD3 mAb, PGE2 inhibited cell proliferation and the production of all the cytokines examined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s840.3) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007845@unknown@formal@none@1@S@Addition of rIL-2 fully restored the proliferative response and partially restored the production of IL-4 and IL-5, but not that of other cytokines.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ril-2") (:form . "rIL-2") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x840.4.1) (:span 120 123)))\n (:nscopes ((:id . :x840.4.1) (:span 120 147)))\n (:identifiers (:sid . :s840.4) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007846@unknown@formal@none@1@S@In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA)/A23187") (:form . "PMA)/A23187") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 143)\n  (:start . 134) (:id . 66))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 153)\n  (:start . 144) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 187)\n  (:start . 178) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s840.5) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007847@unknown@formal@none@1@S@Therefore, the effects of PGE2 vary depending on the mode of T cell activation, and the IL-4 and IL-5 are regulated differently from other cytokines.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "vary") (:form . "vary") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 92) (:start . 88)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 101) (:start . 97)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 115)\n  (:start . 106) (:id . 64))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 127)\n  (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 148)\n  (:start . 139) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s840.6) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007848@unknown@formal@none@1@S@In a mobility shift assay, only the NF-kappa B (p50/p50) homodimer was observed in a complex formed with the kappa B sequence in unstimulated SP-B21 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 13)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 55)\n  (:start . 48) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 66)\n  (:start . 57) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 92)\n  (:start . 85) (:id . 60))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 99) (:start . 93)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 114)\n  (:start . 109) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 125)\n  (:start . 117) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 141)\n  (:start . 129) (:id . 68))\n ((:tag . "NN") (:stem . "sp-b21") (:form . "SP-B21") (:end . 148)\n  (:start . 142) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s840.7) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007850@unknown@formal@none@1@S@Interestingly, PGE2 or di-butyryl (Bt2)cAMP abolished the binding of NF-kappa B (p50/p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA/A23187.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "di-butyryl") (:form . "di-butyryl") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Bt2)cAMP") (:form . "Bt2)cAMP") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "PMA/A23187") (:form . "PMA/A23187") (:end . 187)\n  (:start . 177) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x840.9.1) (:span 168 171)))\n (:nscopes ((:id . :x840.9.1) (:span 168 187)))\n (:identifiers (:sid . :s840.9) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007851@unknown@formal@none@1@S@Our results suggest that the target of PGE2 action is a component in the signal transduction pathway leading to the activation of protein kinase C.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 92)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x840.10.1) (:span 12 19)))\n (:hscopes ((:id . :x840.10.1) (:span 12 146)))\n (:identifiers (:sid . :s840.10) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007852@unknown@formal@none@1@S@However, the inhibition of the T cell activation signals by PGE2 is selective.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s840.11) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007853@unknown@formal@none@1@S@PGE2 enhanced the complex formation with NF-AT, AP-1 and CLE0 sequences when the cells were activated by either anti-CD3 mAb or PMA/A23187 stimulation.@(((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cle0") (:form . "CLE0") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pma/a23187") (:form . "PMA/A23187") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 150)\n  (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s840.12) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007854@unknown@formal@none@1@S@It seems therefore that PGE2, by elevating cAMP levels, interferes with the activation pathway for NF-kappa B but not for NF-AT, AP-1 or CLE0 binding protein.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "elevate") (:form . "elevating") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 133) (:start . 129)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cle0") (:form . "CLE0") (:end . 141) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 149)\n  (:start . 142) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 157)\n  (:start . 150) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x840.13.2) (:span 3 8)))\n (:ncues ((:id . :x840.13.1) (:span 114 117)))\n (:hscopes ((:id . :x840.13.2) (:span 3 157)))\n (:nscopes ((:id . :x840.13.1) (:span 114 157)))\n (:identifiers (:sid . :s840.13) (:did . :|8018594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007855@unknown@formal@none@1@S@Long-term inositol phosphate release, but not tyrosine kinase activity, correlates with IL-2 secretion and NF-AT induction in anti-CD3-activated peripheral human T lymphocytes.@(((:tag . "JJ") (:stem . "long-term") (:form . "Long-term") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "phosphate") (:form . "phosphate") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "anti-cd3-activated") (:form . "anti-CD3-activated")\n  (:end . 144) (:start . 126) (:id . 61))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 161)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 175)\n  (:start . 164) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x841.1.1) (:span 42 45)))\n (:nscopes ((:id . :x841.1.1) (:span 42 70)))\n (:identifiers (:sid . :s841.1) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007856@unknown@formal@none@1@S@The cascade of events within the first few minutes of T cell stimulation has been well characterized.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 72)\n  (:start . 61) (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 100) (:start . 87) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s841.2) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007857@unknown@formal@none@1@S@Although many second messengers have been shown to be necessary and sufficient for T cell activation in a number of model systems, the rate-limiting step in peripheral T cells has not been demonstrated.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "rate-limiting") (:form . "rate-limiting")\n  (:end . 148) (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 167)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 201)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x841.3.1) (:span 180 183)))\n (:nscopes ((:id . :x841.3.1) (:span 131 201)))\n (:identifiers (:sid . :s841.3) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007858@unknown@formal@none@1@S@To model effective versus ineffective CD3-mediated stimulation in peripheral T cells, we used two anti-CD3 mAbs that differ in their ability to stimulate purified T cells: OKT3, which causes early second messenger generation but is unable to activate T cells without a second signal, and 64.1, which stimulates T cell proliferation on its own.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "model") (:form . "model") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "cd3-mediated") (:form . "CD3-mediated") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 62)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "mab") (:form . 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"cells") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 190)\n  (:start . 184) (:id . 73))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 203)\n  (:start . 197) (:id . 75))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 213)\n  (:start . 204) (:id . 76))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 224)\n  (:start . 214) (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 228) (:start . 225)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 231) (:start . 229)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 238)\n  (:start . 232) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 241) (:start . 239)\n  (:id . 81))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 250)\n  (:start . 242) (:id . 82))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 252) (:start . 251)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 258)\n  (:start . 253) (:id . 84))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 266)\n  (:start . 259) (:id . 85))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 268) (:start . 267)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 275)\n  (:start . 269) (:id . 87))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 282)\n  (:start . 276) (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 283) (:start . 282)\n  (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 287) (:start . 284)\n  (:id . 90))\n ((:tag . "CD") (:stem . "64.1") (:form . "64.1") (:end . 292) (:start . 288)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 293) (:start . 292)\n  (:id . 92))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 299)\n  (:start . 294) (:id . 93))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 310)\n  (:start . 300) (:id . 94))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 312) (:start . 311)\n  (:id . 95))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 317) (:start . 313)\n  (:id . 96))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 331) (:start . 318) (:id . 97))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 334) (:start . 332)\n  (:id . 98))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 338) (:start . 335)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 342) (:start . 339)\n  (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 343) (:start . 342)\n  (:id . 101)))@@@1@60@((:ncues ((:id . :x841.4.1) (:span 259 266))\n  ((:id . :x841.4.2) (:span 232 238)))\n (:nscopes ((:id . :x841.4.1) (:span 259 282))\n  ((:id . :x841.4.2) (:span 229 282)))\n (:identifiers (:sid . :s841.4) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007860@unknown@formal@none@1@S@However, the inositol phosphate response was stronger for 64.1 than for OKT3.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "phosphate") (:form . "phosphate") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "CD") (:stem . "64.1") (:form . "64.1") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s841.6) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007861@unknown@formal@none@1@S@To tie these events to gene activation, we measured NF-kappa B and NF-AT activity in the nucleus after anti-CD3 stimulation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "tie") (:form . "tie") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 96)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s841.7) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007862@unknown@formal@none@1@S@Both stimuli induced the appearance of the NF-kappa B components (c-Rel, p65 (RelA), and p50 (NF-kappa B1)) and NF-kappa B DNA binding activity in the nucleus.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 92) (:start . 89)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 102)\n  (:start . 94) (:id . 63))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 105) (:start . 103)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 120)\n  (:start . 112) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 122) (:start . 121)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 126) (:start . 123)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 134)\n  (:start . 127) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 74))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 158)\n  (:start . 151) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s841.8) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007863@unknown@formal@none@1@S@However, only 64.1 induced NF-AT in the nucleus, correlating with its ability to activate T cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "64.1") (:form . "64.1") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "correlate") (:form . "correlating") (:end . 60)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s841.9) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007864@unknown@formal@none@1@S@Thus, NF-AT induction and IL-2 secretion were correlated with the levels of inositol phosphate release but not with gross levels of tyrosine kinase activity induced late following the response.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "phosphate") (:form . "phosphate") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "gross") (:form . "gross") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 192)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x841.10.1) (:span 107 110)))\n (:nscopes ((:id . :x841.10.1) (:span 107 192)))\n (:identifiers (:sid . :s841.10) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007865@unknown@formal@none@1@S@On the other hand, NF-kappa B induction and IL-2 receptor expression occurred even with the smaller second messenger response generated by OKT3.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 39)\n  (:start . 30) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s841.11) (:did . :|8039243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5007867@unknown@formal@none@1@S@Several mammalian responses to UV irradiation, including the activation of NF-kappa B, are believed to involve tyrosine phosphorylation.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 135) (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x842.2.1) (:span 91 99)))\n (:hscopes ((:id . :x842.2.1) (:span 0 135)))\n (:identifiers (:sid . :s842.2) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007868@unknown@formal@none@1@S@UV irradiation and H2O2 treatment of T lymphocytes induce protein tyrosine phosphorylation and Ca2+ signals similar to those observed following biological stimulation.@(((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 90) (:start . 75) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 154)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 166)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s842.3) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007870@unknown@formal@none@1@S@Normal T lymphocytes whose surface expression of CD3 was depleted showed impaired UV-induced tyrosine phosphorylation and Ca2+ signals.@(((:tag . "JJ") (:stem . "normal") (:form . "Normal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "deplete") (:form . "depleted") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 72) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "uv-induced") (:form . "UV-induced") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 117) (:start . 102) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s842.5) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007871@unknown@formal@none@1@S@Similarly, Jurkat T cell lines deficient in CD3 or CD45 expression also gave impaired UV responses.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "give") (:form . "gave") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s842.6) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007872@unknown@formal@none@1@S@However, all these cell types still gave strong Ca2+ and tyrosine phosphorylation responses to H2O2.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "give") (:form . "gave") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 81) (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s842.7) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007873@unknown@formal@none@1@S@The T cell tyrosine kinase ZAP-70 was found to be highly responsive to UV and H2O2 treatment.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s842.8) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007874@unknown@formal@none@1@S@ZAP-70 responsiveness to UV required expression of both CD3 and CD45, whereas only CD3 was required for the response to H2O2.@(((:tag . "NNP") (:stem . "ZAP-70") (:form . "ZAP-70") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 21) (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s842.9) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007875@unknown@formal@none@1@S@UV-induced activation of NF-kappa B was blocked by CD3 depletion, indicating the importance of such cell surface molecules in biological responses to UV.@(((:tag . "JJ") (:stem . "uv-induced") (:form . "UV-induced") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s842.10) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007876@unknown@formal@none@1@S@In nonlymphoid cells, the epidermal growth factor receptor displayed increased tyrosine phosphorylation within seconds of UV irradiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epidermal") (:form . "epidermal") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 103) (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 110)\n  (:start . 104) (:id . 55))\n ((:tag . "NNS") (:stem . "second") (:form . "seconds") (:end . 118)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 136)\n  (:start . 125) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s842.11) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007877@unknown@formal@none@1@S@These results suggest that UV-induced signal transduction is mediated via cell surface receptors that normally respond to biological stimulation, whereas H2O2 is able to partially bypass this requirement.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "uv-induced") (:form . "UV-induced") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 132)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 144)\n  (:start . 133) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 153)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 158) (:start . 154)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 166) (:start . 162)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 179)\n  (:start . 170) (:id . 67))\n ((:tag . "VB") (:stem . "bypass") (:form . "bypass") (:end . 186)\n  (:start . 180) (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 203)\n  (:start . 192) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x842.12.1) (:span 14 21)))\n (:hscopes ((:id . :x842.12.1) (:span 14 203)))\n (:identifiers (:sid . :s842.12) (:did . :|8051172|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007878@unknown@formal@none@1@S@Inhibition of NF-kappa B by sodium salicylate and aspirin [see comments]@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s843.1) (:did . :|8052854|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007880@unknown@formal@none@1@S@The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 27) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 103)\n  (:start . 98) (:id . 56))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "VBZ") (:stem . "explain") (:form . "explains") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 159)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s843.3) (:did . :|8052854|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007881@unknown@formal@none@1@S@This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s843.4) (:did . :|8052854|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007882@unknown@formal@none@1@S@Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.@(((:tag . "NN") (:stem . "sodium") (:form . "Sodium") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "salicylate") (:form . "salicylate") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "aspirin") (:form . "aspirin") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 65)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 137) (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 143)\n  (:start . 138) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 191)\n  (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s843.5) (:did . :|8052854|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007883@unknown@formal@none@1@S@Positive and negative regulation of IL-2 gene expression: role of multiple regulatory sites.@(((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s844.1) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007884@unknown@formal@none@1@S@Interleukin 2 (IL-2) is an important lymphokine required in the process of T cell activation, proliferation, clonal expansion and differentiation.@(((:tag . "NNP") (:stem . "Interleukin") (:form . "Interleukin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 36)\n  (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 107) (:start . 94) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 145) (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s844.2) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007885@unknown@formal@none@1@S@The IL-2 gene displays both T cell specific and inducible expression: it is only expressed in CD4+ T cells after antigenic or mitogenic stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 122)\n  (:start . 113) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 135)\n  (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 147)\n  (:start . 136) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s844.3) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007886@unknown@formal@none@1@S@Several cis-acting regulatory sites are required for induction of the IL-2 gene after stimulation.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s844.4) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007887@unknown@formal@none@1@S@In this study, we have analysed the function of these cis-acting regulatory sites in the context of the native IL-2 enhancer and promoter sequence.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s844.5) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007888@unknown@formal@none@1@S@The results of this study suggest that the NFAT (-276 to -261), the distal octamer (-256 to -248) and the proximal octamer (-75 to -66) sites not only act as enhancers of IL-2 gene transcription in the presence of cellular stimulation, but also have a silencing effect on IL-2 gene expression in resting cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . 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5007890@unknown@formal@none@1@S@Finally, the AP-1 (-186 to -176) and the kappa B sites (-206 to -195) respond to different cellular activation in EL4 cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-186") (:form . "-186") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "CD") (:stem . "-176") (:form . "-176") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 54) (:start . 49)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-206") (:form . "-206") (:end . 60) (:start . 56)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-195") (:form . "-195") (:end . 68) (:start . 64)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 77)\n  (:start . 70) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 90)\n  (:start . 81) (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 99)\n  (:start . 91) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 66))\n ((:tag . "NN") (:stem . "el4") (:form . "EL4") (:end . 117) (:start . 114)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s844.8) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007891@unknown@formal@none@1@S@The AP-1 site mediated the response to PMA stimulation while the kappa B site responded to IL-1 stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 107)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s844.9) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007892@unknown@formal@none@1@S@These data suggest that the regulation of IL-2 gene expression is a complex process and multiple cis-acting regulatory sites interact to exert different effects in T cells representative of alternative stages of differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 68))\n ((:tag . "JJ") (:stem . "representative") (:form . "representative")\n  (:end . 186) (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 201)\n  (:start . 190) (:id . 71))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 208)\n  (:start . 202) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 73))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 227) (:start . 212) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x844.10.1) (:span 11 18)))\n (:hscopes ((:id . :x844.10.1) (:span 11 227)))\n (:identifiers (:sid . :s844.10) (:did . :|8054477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007893@unknown@formal@none@1@S@Superantigens activate HIV-1 gene expression in monocytic cells.@(((:tag . "NNS") (:stem . "superantigen") (:form . "Superantigens")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s845.1) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007894@unknown@formal@none@1@S@Binding of superantigens to MHC class II molecules results in transduction of biochemical signals leading to cellular activation and gene expression.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "superantigen") (:form . "superantigens")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s845.2) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007895@unknown@formal@none@1@S@We demonstrate that the staphylococcal superantigens toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin A (SEA) activate HIV-1-LTR-driven transcription of chloramphenicol acetyl transferase in the human monocytic cell line THP-1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "superantigen") (:form . "superantigens")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "toxic") (:form . "toxic") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "toxin-1") (:form . "toxin-1") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tsst-1") (:form . "TSST-1") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 109) (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "enterotoxin") (:form . "enterotoxin") (:end . 121)\n  (:start . 110) (:id . 57))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 123) (:start . 122)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SEA") (:form . "SEA") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "hiv-1-ltr-driven") (:form . "HIV-1-LTR-driven")\n  (:end . 155) (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 169) (:start . 156) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 188) (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 195)\n  (:start . 189) (:id . 67))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 207)\n  (:start . 196) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 220)\n  (:start . 215) (:id . 71))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 230)\n  (:start . 221) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 235) (:start . 231)\n  (:id . 73))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 240) (:start . 236)\n  (:id . 74))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 246)\n  (:start . 241) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s845.3) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007896@unknown@formal@none@1@S@Induction of HIV-1-LTR-driven transcription in THP-1 cells by superantigens was associated with the induction of nuclear factor-kappa B DNA-binding activity.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hiv-1-ltr-driven") (:form . "HIV-1-LTR-driven")\n  (:end . 29) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "superantigen") (:form . "superantigens")\n  (:end . 75) (:start . 62) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 133)\n  (:start . 121) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 147)\n  (:start . 136) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 156)\n  (:start . 148) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s845.4) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007897@unknown@formal@none@1@S@Superantigens also increased viral protein secretion from the granulocyte-macrophage colony-stimulating factor-pretreated chronically infected human monocytic cell line U1.@(((:tag . "NNP") (:stem . "Superantigen") (:form . "Superantigens")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 84) (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 103) (:start . 85) (:id . 51))\n ((:tag . "JJ") (:stem . "factor-pretreated") (:form . "factor-pretreated")\n  (:end . 121) (:start . 104) (:id . 52))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 133)\n  (:start . 122) (:id . 53))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 142)\n  (:start . 134) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 148)\n  (:start . 143) (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 158)\n  (:start . 149) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 168) (:start . 164)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 171) (:start . 169)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s845.5) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007898@unknown@formal@none@1@S@Induction of HIV-1 gene expression in monocytic cells by superantigens occurred via tumor necrosis factor-alpha-dependent and -independent mechanisms.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "superantigen") (:form . "superantigens")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "factor-alpha-dependent")\n  (:form . "factor-alpha-dependent") (:end . 121) (:start . 99) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 138)\n  (:start . 126) (:id . 58))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 149)\n  (:start . 139) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s845.6) (:did . :|8062448|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007900@unknown@formal@none@1@S@DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.@(((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 31) (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 42)\n  (:start . 32) (:id . 45))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 53)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hepatic") (:form . "hepatic") (:end . 64)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HLF") (:form . "HLF") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "t(17;19)") (:form . "t(17;19)") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 123) (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "chimera") (:form . "chimera") (:end . 140)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 148)\n  (:start . 141) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s846.1) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
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5007902@unknown@formal@none@1@S@An in vitro binding site selection procedure was used to determine DNA sequences preferentially bound by wild-type HLF and chimeric E2A-HLF proteins isolated from various t(17;19)-bearing leukemias.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 95) (:start . 81) (:id . 55))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "hlf") (:form . "HLF") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 170)\n  (:start . 163) (:id . 66))\n ((:tag . "JJ") (:stem . "t(17;19)-bearing") (:form . "t(17;19)-bearing")\n  (:end . 187) (:start . 171) (:id . 67))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 197)\n  (:start . 188) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s846.3) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007903@unknown@formal@none@1@S@All were found to selectively bind the consensus sequence 5'-GTTACGTAAT-3' with high affinity.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "5'-gttacgtaat-3") (:form . "5'-GTTACGTAAT-3")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s846.4) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007904@unknown@formal@none@1@S@Wild-type and chimeric HLF proteins also bound closely related sites identified previously for bZIP proteins of both the proline- and acidic amino acid-rich (PAR) and C/EBP subfamilies; however, E2A-HLF proteins were significantly less tolerant of certain deviations from the HLF consensus binding site.@(((:tag . "JJ") (:stem . "wild-type") (:form . "Wild-type") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "hlf") (:form . "HLF") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "bind") (:form . 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"both") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proline-") (:form . "proline-") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 140)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "JJ") (:stem . "acid-rich") (:form . "acid-rich") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PAR") (:form . "PAR") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "NNS") (:stem . "subfamily") (:form . "subfamilies") (:end . 184)\n  (:start . 173) (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 202)\n  (:start . 195) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 211)\n  (:start . 203) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 216) (:start . 212)\n  (:id . 76))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 230) (:start . 217) (:id . 77))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 235) (:start . 231)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 244)\n  (:start . 236) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 247) (:start . 245)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 255)\n  (:start . 248) (:id . 81))\n ((:tag . "NNS") (:stem . "deviation") (:form . "deviations") (:end . 266)\n  (:start . 256) (:id . 82))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 271) (:start . 267)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 275) (:start . 272)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "HLF") (:form . "HLF") (:end . 279) (:start . 276)\n  (:id . 85))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 289)\n  (:start . 280) (:id . 86))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 297)\n  (:start . 290) (:id . 87))\n ((:tag . "NN") (:stem . "site") (:form . 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5007905@unknown@formal@none@1@S@These differences were directly attributable to loss of an HLF ancillary DNA-binding domain in all E2A-HLF chimeras and were further exacerbated by a zipper mutation in one isolate.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "attributable") (:form . "attributable") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HLF") (:form . "HLF") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ancillary") (:form . "ancillary") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "chimera") (:form . "chimeras") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "VBN") (:stem . "exacerbate") (:form . "exacerbated") (:end . 144)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "zipper") (:form . "zipper") (:end . 156)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "isolate") (:form . "isolate") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s846.6) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007906@unknown@formal@none@1@S@Both wild-type and chimeric HLF proteins displayed transcriptional activator properties in lymphoid and nonlymphoid cells on reporter genes containing HLF or C/EBP consensus binding sites.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "hlf") (:form . "HLF") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 66) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 99)\n  (:start . 91) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 115)\n  (:start . 104) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 133)\n  (:start . 125) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 139)\n  (:start . 134) (:id . 59))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 150)\n  (:start . 140) (:id . 60))\n ((:tag . "NNP") (:stem . "HLF") (:form . "HLF") (:end . 154) (:start . 151)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 157) (:start . 155)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 163)\n  (:start . 158) (:id . 63))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 173)\n  (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 181)\n  (:start . 174) (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 187)\n  (:start . 182) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s846.7) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007907@unknown@formal@none@1@S@But on reporter genes with nonoptimal binding sites, their transcriptional properties diverged and E2A-HLF competitively inhibited activation by wild-type PAR proteins.@(((:tag . "CC") (:stem . "but") (:form . "But") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nonoptimal") (:form . "nonoptimal") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 58)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 74) (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "VBD") (:stem . "diverge") (:form . "diverged") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "e2a-hlf") (:form . "E2A-HLF") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "RB") (:stem . "competitively") (:form . "competitively")\n  (:end . 120) (:start . 107) (:id . 57))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 130)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 154)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "par") (:form . "PAR") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s846.8) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007908@unknown@formal@none@1@S@These findings establish a spectrum of binding site-specific transcriptional properties for E2A-HLF which may preferentially activate expression of select subordinate genes as a homodimer and potentially antagonize expression of others through heteromeric interactions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "spectrum") (:form . "spectrum") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "site-specific") (:form . "site-specific")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 76) (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "E2A-HLF") (:form . "E2A-HLF") (:end . 99)\n  (:start . 92) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 124) (:start . 110) (:id . 56))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 133)\n  (:start . 125) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "select") (:form . "select") (:end . 154)\n  (:start . 148) (:id . 60))\n ((:tag . "JJ") (:stem . "subordinate") (:form . "subordinate") (:end . 166)\n  (:start . 155) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 172)\n  (:start . 167) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 64))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 187)\n  (:start . 178) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 66))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 203)\n  (:start . 192) (:id . 67))\n ((:tag . "VBP") (:stem . "antagonize") (:form . "antagonize") (:end . 214)\n  (:start . 204) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 225)\n  (:start . 215) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 235)\n  (:start . 229) (:id . 71))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 243)\n  (:start . 236) (:id . 72))\n ((:tag . "JJ") (:stem . "heteromeric") (:form . "heteromeric") (:end . 255)\n  (:start . 244) (:id . 73))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 268)\n  (:start . 256) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x846.9.1) (:span 192 203))\n  ((:id . :x846.9.2) (:span 106 109)))\n (:hscopes ((:id . :x846.9.1) (:span 192 268))\n  ((:id . :x846.9.2) (:span 106 268)))\n (:identifiers (:sid . :s846.9) (:did . :|8065331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007910@unknown@formal@none@1@S@Co-stimulation of T-lymphocytes by T-cell receptor (TcR) occupancy and activation of the CD28 surface molecule results in enhanced proliferation and interleukin 2 (IL-2) production.@(((:tag . "NN") (:stem . "co-stimulation") (:form . "Co-stimulation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TcR") (:form . "TcR") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 144) (:start . 131) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 168) (:start . 164)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 180)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s847.2) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007911@unknown@formal@none@1@S@The increase in IL-2 gene expression triggered by CD28 involves a kappa B-like sequence in the 5'-regulatory region of the IL-2 promoter, called CD28-responsive element.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "5'-regulatory") (:form . "5'-regulatory")\n  (:end . 108) (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . "JJ") (:stem . "cd28-responsive") (:form . "CD28-responsive")\n  (:end . 160) (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 168)\n  (:start . 161) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s847.3) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007912@unknown@formal@none@1@S@Stimulation of T-cells by agonistic anti-CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate (PMA)- or TcR-derived signals induces the enhanced activation of the transcription factor NF-kappa B.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "agonistic") (:form . "agonistic") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 97)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 108)\n  (:start . 98) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PMA)-") (:form . "PMA)-") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "tcr-derived") (:form . "TcR-derived") (:end . 130)\n  (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 138)\n  (:start . 131) (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 146)\n  (:start . 139) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 159)\n  (:start . 151) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 198)\n  (:start . 192) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 207)\n  (:start . 199) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 209) (:start . 208)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s847.4) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007913@unknown@formal@none@1@S@Here we report that CD28 engagement, however, exerts opposite effects on the transcription factor AP-1.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s847.5) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007914@unknown@formal@none@1@S@Whereas anti-CD28 together with PMA increased the DNA binding and trans-activation activity of NF-kappa B, PMA-induced activation of AP-1 was significantly suppressed.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 82) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 129)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 155) (:start . 142) (:id . 63))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 166)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s847.6) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007915@unknown@formal@none@1@S@The inhibitory effect exerted by anti-CD28 was observed at the level of DNA binding as well as in functional reporter-gene assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . "JJ") (:stem . "reporter-gene") (:form . "reporter-gene")\n  (:end . 122) (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s847.7) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007916@unknown@formal@none@1@S@These results suggest that the two transcription factors are independently regulated and may perform different functions during T-cell activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 74) (:start . 61) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 127)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x847.8.1) (:span 89 92)) ((:id . :x847.8.2) (:span 14 21)))\n (:hscopes ((:id . :x847.8.1) (:span 89 145))\n  ((:id . :x847.8.2) (:span 14 145)))\n (:identifiers (:sid . :s847.8) (:did . :|8067997|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007917@unknown@formal@none@1@S@Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 67) (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s848.1) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007918@unknown@formal@none@1@S@IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells.@(((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 14) (:start . 8)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 99) (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s848.2) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007920@unknown@formal@none@1@S@Anti-CD28-stimulated T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28 Abs resulted in a synergistic induction of IL-8 secretion.@(((:tag . "JJ") (:stem . "anti-cd28-stimulated")\n  (:form . "Anti-CD28-stimulated") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 49)\n  (:start . 38) (:id . 46))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 57)\n  (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "additionally") (:form . "additionally") (:end . 79)\n  (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 94) (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 108)\n  (:start . 100) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 135)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 162)\n  (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 180)\n  (:start . 171) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s848.4) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007921@unknown@formal@none@1@S@Sequence homology, single nucleotide mutations, and anti-CD28 Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "function") (:form . "functioned") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s848.5) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007922@unknown@formal@none@1@S@Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 70)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 150) (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x848.6.1) (:span 32 35)))\n (:nscopes ((:id . :x848.6.1) (:span 32 45)))\n (:identifiers (:sid . :s848.6) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007923@unknown@formal@none@1@S@The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 146)\n  (:start . 134) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "persistence") (:form . "persistence") (:end . 162)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 172)\n  (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "disorder") (:form . "disorders") (:end . 182)\n  (:start . 173) (:id . 70))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 196) (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 209)\n  (:start . 200) (:id . 73))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 216)\n  (:start . 210) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 224) (:start . 220)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 230) (:start . 226)\n  (:id . 78))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 233) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "psoriasis") (:form . "psoriasis") (:end . 243)\n  (:start . 234) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 258)\n  (:start . 248) (:id . 82))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 268)\n  (:start . 259) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x848.7.1) (:span 100 103)))\n (:hscopes ((:id . :x848.7.1) (:span 100 268)))\n (:identifiers (:sid . :s848.7) (:did . :|8077662|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007924@unknown@formal@none@1@S@Signals and nuclear factors that regulate the expression of interleukin-4 and interleukin-5 genes in helper T cells.@(((:tag . "NNS") (:stem . "signal") (:form . "Signals") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-5") (:form . "interleukin-5")\n  (:end . 91) (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s849.1) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007925@unknown@formal@none@1@S@Mouse thymoma line EL-4 cells produce cytokines such as interleukin (IL)-2, IL-3, IL-4, IL-10, and granulocyte-macrophage colony-stimulating factor in response to phorbol 12-myristate 13-acetate (PMA).@(((:tag . "NNP") (:stem . "Mouse") (:form . "Mouse") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thymoma") (:form . "thymoma") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IL)-2") (:form . "IL)-2") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 121) (:start . 99) (:id . 62))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 140) (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 170)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 183)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 194)\n  (:start . 184) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 196) (:start . 195)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s849.2) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007926@unknown@formal@none@1@S@EL-4 cells also produce low levels of IL-5 when stimulated by PMA alone; however, cAMP greatly augments PMA-dependent IL-5 production.@(((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "JJ") (:stem . "pma-dependent") (:form . "PMA-dependent")\n  (:end . 117) (:start . 104) (:id . 61))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s849.3) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007927@unknown@formal@none@1@S@A transient transfection assay revealed that two signals, PMA and cAMP, are required for optimal activation of the IL-5 promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s849.4) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007928@unknown@formal@none@1@S@In contrast, cAMP almost completely inhibited the PMA-dependent activation of the endogenous IL-2 gene, as well as the transfected IL-2 promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pma-dependent") (:form . "PMA-dependent")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s849.5) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007930@unknown@formal@none@1@S@One of the nuclear factors (NFs) that regulates the response of the IL-5 promoter to cAMP and PMA has properties similar to NF for activated t cell.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NFs") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 101) (:start . 98)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 112)\n  (:start . 102) (:id . 63))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 120)\n  (:start . 113) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 126) (:start . 124)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 140)\n  (:start . 131) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "t") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 147) (:start . 143)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s849.7) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007931@unknown@formal@none@1@S@The P sequence of the IL-4 gene, defined as a responsive element for PMA and calcium ionophore (A23187), shares sequence similarity with the NF kappa B and the NF-activated T cell binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 40)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 56)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 94)\n  (:start . 85) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "A23187") (:form . "A23187") (:end . 102)\n  (:start . 96) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "share") (:form . "shares") (:end . 111)\n  (:start . 105) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 120)\n  (:start . 112) (:id . 65))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 131)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 143) (:start . 141)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 149)\n  (:start . 144) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "nf-activated") (:form . "NF-activated") (:end . 172)\n  (:start . 160) (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 77))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 193)\n  (:start . 188) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s849.8) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007932@unknown@formal@none@1@S@We attempted to determine whether NF(P), a nuclear factor specific for the P sequence, is related to NF-kappa B and nuclear factor for activated T cell (NF-AT).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "attempt") (:form . "attempted") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 144)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 158)\n  (:start . 153) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x849.9.1) (:span 26 33)))\n (:hscopes ((:id . :x849.9.1) (:span 26 159)))\n (:identifiers (:sid . :s849.9) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007933@unknown@formal@none@1@S@In electromobility shift assays both NF-kappa B (P65 or P65/P50 heterodimer) and NF-AT bound to the P sequence.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "electromobility") (:form . "electromobility")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "P65") (:form . "P65") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "P65/P50") (:form . "P65/P50") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 75)\n  (:start . 64) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s849.10) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007934@unknown@formal@none@1@S@However, sequence specificity of NF-AT was more similar to that of NF(P), and only a small amount of P65 was detected in NF(P).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "NF(P)") (:form . "NF(P)") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 97)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "P65") (:form . "P65") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 117)\n  (:start . 109) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s849.11) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007935@unknown@formal@none@1@S@These results indicate that a component or components of NF-AT have the potential to reconstitute NF(P), whereas NF-kappa B alone does not account for NF(P) in Jurkat crude extract.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VB") (:stem . "reconstitute") (:form . "reconstitute") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "NF(P)") (:form . "NF(P)") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . "JJ") (:stem . "crude") (:form . "crude") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x849.12.2) (:span 14 27)))\n (:ncues ((:id . :x849.12.1) (:span 135 138)))\n (:hscopes ((:id . :x849.12.2) (:span 14 180)))\n (:nscopes ((:id . :x849.12.1) (:span 135 180)))\n (:identifiers (:sid . :s849.12) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007936@unknown@formal@none@1@S@Taken together, these results suggest that NF-AT-like factors are involved in the regulation of IL-4 and IL-5 genes.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nf-at-like") (:form . "NF-AT-like") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x849.13.1) (:span 30 37)))\n (:hscopes ((:id . :x849.13.1) (:span 30 115)))\n (:identifiers (:sid . :s849.13) (:did . :|8083467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007937@unknown@formal@none@1@S@Structure and expression of the human GATA3 gene.@(((:tag . "NN") (:stem . "structure") (:form . "Structure") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s850.1) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007938@unknown@formal@none@1@S@GATA3, a member of the GATA family that is abundantly expressed in the T-lymphocyte lineage, is thought to participate in T-cell receptor gene activation through binding to enhancers.@(((:tag . "NNP") (:stem . "GATA3") (:form . "GATA3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 53)\n  (:start . 43) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte") (:end . 83)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 118)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 182)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x850.2.1) (:span 96 103)))\n (:hscopes ((:id . :x850.2.1) (:span 0 182)))\n (:identifiers (:sid . :s850.2) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007940@unknown@formal@none@1@S@We show that the human GATA3 gene contains six exons distributed over 17 kb of DNA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s850.4) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007941@unknown@formal@none@1@S@The two human GATA3 zinc fingers are encoded by two separate exons highly conserved with those of GATA1, but no other structural homologies between these two genes can be found.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GATA1") (:form . "GATA1") (:end . 103)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 128)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "homology") (:form . "homologies") (:end . 139)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 163)\n  (:start . 158) (:id . 69))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x850.5.1) (:span 109 111)))\n (:nscopes ((:id . :x850.5.1) (:span 109 176)))\n (:identifiers (:sid . :s850.5) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007942@unknown@formal@none@1@S@The human and mouse GATA3 transcription units start at a major initiation site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "unit") (:form . "units") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "start") (:form . "start") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s850.6) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007943@unknown@formal@none@1@S@The promoter sequence analysis of these two genes revealed that they are embedded within a CpG island and share structural features often found in the promoters of housekeeping genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "embed") (:form . "embedded") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CpG") (:form . "CpG") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "housekeeping") (:form . "housekeeping") (:end . 176)\n  (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s850.7) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007944@unknown@formal@none@1@S@Finally, we show that a DNA fragment containing the human GATA3 transcription unit, 3 kb upstream from the initiation site and 4 kb downstream from the polyadenylation site, displays T-cell specificity.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 142)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "polyadenylation") (:form . "polyadenylation")\n  (:end . 167) (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 182)\n  (:start . 174) (:id . 73))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 189)\n  (:start . 183) (:id . 74))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 201)\n  (:start . 190) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s850.8) (:did . :|8088776|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007945@unknown@formal@none@1@S@Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.@(((:tag . "NN") (:stem . "overproduction") (:form . "Overproduction")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nfkb2") (:form . "NFKB2") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lyt-10") (:form . "lyt-10") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 55)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "JJ") (:stem . "tax-mediated") (:form . "Tax-mediated") (:end . 79)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 96) (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s851.1) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007946@unknown@formal@none@1@S@Molecular, biochemical and epidemiological evidence implicate HTLV-I as an etiologic agent of adult T cell leukemia (ATL).@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epidemiological") (:form . "epidemiological")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "VBP") (:stem . "implicate") (:form . "implicate") (:end . 61)\n  (:start . 52) (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "etiologic") (:form . "etiologic") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s851.2) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007947@unknown@formal@none@1@S@The Tax protein of HTLV-I, a positive transcriptional activator of HTLV-I gene expression, is a viral oncogene that also increases transcription of cellular genes including GM-CSF, IL-2R alpha and IL-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 53) (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 172)\n  (:start . 163) (:id . 68))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 179)\n  (:start . 173) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 186)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 192)\n  (:start . 187) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 201) (:start . 197)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s851.3) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007948@unknown@formal@none@1@S@One of the cellular targets of the trans-activating effects of Tax is the NF-kappa B/Rel family of transcription factors, pleiotropic regulators of immunoregulatory, cytokine and viral gene expression.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 51) (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 133)\n  (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 144)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 164) (:start . 148) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 184)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 200)\n  (:start . 190) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s851.4) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007950@unknown@formal@none@1@S@Most importantly, we show a Tax-dependent correlation between expression of NFKB2(p100) and processing to the DNA binding NFKB2(p52) form, induction of c-Rel, and trans-activation of NF-kappa B-mediated gene expression.@(((:tag . "RBS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "importantly") (:form . "importantly") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tax-dependent") (:form . "Tax-dependent")\n  (:end . 41) (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "NFKB2(p100)") (:form . "NFKB2(p100)") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 102)\n  (:start . 92) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "NFKB2(p52)") (:form . "NFKB2(p52)") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 179) (:start . 163) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 191)\n  (:start . 183) (:id . 70))\n ((:tag . "JJ") (:stem . "b-mediated") (:form . "B-mediated") (:end . 202)\n  (:start . 192) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 218)\n  (:start . 208) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s851.6) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007951@unknown@formal@none@1@S@Furthermore, the NFKB2 precursor is physically associated with c-Rel and with Tax in HTLV-I infected cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nfkb2") (:form . "NFKB2") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s851.7) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007952@unknown@formal@none@1@S@We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel, NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nfkb2") (:form . "NFKB2") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "RB") (:stem . "otherwise") (:form . "otherwise") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 111)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 159) (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 168)\n  (:start . 163) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nfkb2") (:form . "NFKB2") (:end . 175)\n  (:start . 170) (:id . 67))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 182)\n  (:start . 176) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 195)\n  (:start . 187) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 197) (:start . 196)\n  (:id . 71))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 208)\n  (:start . 198) (:id . 72))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 216)\n  (:start . 209) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 232)\n  (:start . 221) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 235) (:start . 233)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 244)\n  (:start . 236) (:id . 77))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 259) (:start . 245) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 262) (:start . 260)\n  (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 264) (:start . 263)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 270)\n  (:start . 265) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 273) (:start . 271)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 280)\n  (:start . 274) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x851.8.1) (:span 3 10)))\n (:hscopes ((:id . :x851.8.1) (:span 3 280)))\n (:identifiers (:sid . :s851.8) (:did . :|8108127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007953@unknown@formal@none@1@S@trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6.@(((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "herpesvirus-6") (:form . "herpesvirus-6")\n  (:end . 92) (:start . 79) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s852.1) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007954@unknown@formal@none@1@S@Human herpesvirus 6 (HHV-6) is a lymphotropic herpesvirus, and in vitro, it can productively infect human CD4+ T cells as HIV-1.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hhv-6") (:form . "HHV-6") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 45)\n  (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "RB") (:stem . "productively") (:form . "productively") (:end . 92)\n  (:start . 80) (:id . 59))\n ((:tag . "VB") (:stem . "infect") (:form . "infect") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 127)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s852.2) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007955@unknown@formal@none@1@S@Co-infection of T cells by HIV-1 and HHV-6 can lead to both activation of the HIV-1 promoter and acceleration of the cytopathic effects.@(((:tag . "NN") (:stem . "co-infection") (:form . "Co-infection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "acceleration") (:form . "acceleration") (:end . 109)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytopathic") (:form . "cytopathic") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x852.3.1) (:span 43 46)))\n (:hscopes ((:id . :x852.3.1) (:span 43 135)))\n (:identifiers (:sid . :s852.3) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007956@unknown@formal@none@1@S@An HHV-6 (GS) cDNA clone, pCD41, encoding for a 41-kDa nuclear protein was identified and characterized previously (Chang and Balachandran, J. Virol. 65, 2884-2894 and 7085, 1991).@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HHV-6") (:form . "HHV-6") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GS") (:form . "GS") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 13) (:start . 12)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 18) (:start . 14)\n  (:id . 47))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 24) (:start . 19)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 31) (:start . 26)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 41)\n  (:start . 33) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "41-kda") (:form . "41-kDa") (:end . 54)\n  (:start . 48) (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 85)\n  (:start . 75) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 103) (:start . 90) (:id . 61))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 114)\n  (:start . 104) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Chang") (:form . "Chang") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Balachandran") (:form . "Balachandran")\n  (:end . 138) (:start . 126) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "J.") (:form . "J.") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Virol.") (:form . "Virol.") (:end . 149)\n  (:start . 143) (:id . 69))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 152) (:start . 150)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 71))\n ((:tag . "CD") (:stem . "2884-2894") (:form . "2884-2894") (:end . 163)\n  (:start . 154) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 73))\n ((:tag . "CD") (:stem . "7085") (:form . "7085") (:end . 172) (:start . 168)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 75))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 178) (:start . 174)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s852.4) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007957@unknown@formal@none@1@S@Sequence analyses show that this protein has significant homology with the human cytomegalovirus UL44 gene coding for the ICP36 family of early-late-class phosphoprotein.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 96) (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "ul44") (:form . "UL44") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ICP36") (:form . "ICP36") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "early-late-class") (:form . "early-late-class")\n  (:end . 154) (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 169) (:start . 155) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s852.5) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007958@unknown@formal@none@1@S@Using this cDNA as the probe, a 3.8-kb EcoRI genomic fragment encoding the HHV-6(GS)P41 was cloned and designated as pGD41.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "3.8-kb") (:form . "3.8-kb") (:end . 38)\n  (:start . 32) (:id . 50))\n ((:tag . "NNP") (:stem . "EcoRI") (:form . "EcoRI") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 52)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "HHV-6(GS)P41") (:form . "HHV-6(GS)P41") (:end . 87)\n  (:start . 75) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pgd41") (:form . "pGD41") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s852.6) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007960@unknown@formal@none@1@S@Sequence analyses of pCD41 indicate that there are two potential open reading frames (ORFs), A and B, which are homologous to the ORFs found in the genomic clone pGD41.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORFs") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 122)\n  (:start . 112) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 67))\n ((:tag . "NNPS") (:stem . "ORF") (:form . "ORFs") (:end . 134) (:start . 130)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 140)\n  (:start . 135) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 155)\n  (:start . 148) (:id . 72))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 161)\n  (:start . 156) (:id . 73))\n ((:tag . "NN") (:stem . "pgd41") (:form . "pGD41") (:end . 167)\n  (:start . 162) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x852.8.1) (:span 27 40)))\n (:hscopes ((:id . :x852.8.1) (:span 27 167)))\n (:identifiers (:sid . :s852.8) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007961@unknown@formal@none@1@S@Deletion constructs of the pCD41 clone demonstrated that ORF-A was critical for the HIV LTR activation.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ORF-A") (:form . "ORF-A") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s852.9) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007962@unknown@formal@none@1@S@Deletion analyses of the pCD41 ORF-A and the use of promoter constructs further mapped an internal functional promoter within the pCD41 sequence that can direct the synthesis of the trans-activating protein.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ORF-A") (:form . "ORF-A") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "map") (:form . "mapped") (:end . 86) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 160)\n  (:start . 154) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 198) (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 206)\n  (:start . 199) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s852.10) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007963@unknown@formal@none@1@S@By using HIV LTR deletion mutants, the NF-kappa B binding sites were found to be critical for response to the pCD41 trans-activation.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pcd41") (:form . "pCD41") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "trans-activation") (:form . "trans-activation")\n  (:end . 132) (:start . 116) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s852.11) (:did . :|8122364|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007964@unknown@formal@none@1@S@Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632]@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 88) (:start . 70) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 119)\n  (:start . 112) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 160)\n  (:start . 153) (:id . 64))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 168)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Proc") (:form . "Proc") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Natl") (:form . "Natl") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Acad") (:form . "Acad") (:end . 186) (:start . 182)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Sci") (:form . "Sci") (:end . 190) (:start . 187)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "CD") (:stem . "1995") (:form . "1995") (:end . 201) (:start . 197)\n  (:id . 74))\n ((:tag . "IN") (:stem . "apr") (:form . "Apr") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "CD") (:stem . "11;92(8):3632") (:form . "11;92(8):3632")\n  (:end . 219) (:start . 206) (:id . 76))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 220) (:start . 219)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s853.1) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007965@unknown@formal@none@1@S@The host response to Mycobacterium tuberculosis includes granuloma formation at sites of infection and systemic symptoms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 47)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "granuloma") (:form . "granuloma") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 120)\n  (:start . 112) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s853.2) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007966@unknown@formal@none@1@S@Cytokines have been identified by immunohistochemistry in granulomas in animal models of bacillus Calmette-Guerin (BCG) infection and are released by mononuclear phagocytes upon stimulation by mycobacterial proteins.@(((:tag . "NNPS") (:stem . "Cytokine") (:form . "Cytokines") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunohistochemistry")\n  (:form . "immunohistochemistry") (:end . 54) (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "granuloma") (:form . "granulomas") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bacillus") (:form . "bacillus") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "NNP") (:stem . "Calmette-Guerin") (:form . "Calmette-Guerin")\n  (:end . 113) (:start . 98) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "BCG") (:form . "BCG") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 161)\n  (:start . 150) (:id . 64))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 172)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 189)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 192) (:start . 190)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mycobacterial") (:form . "mycobacterial")\n  (:end . 206) (:start . 193) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 215)\n  (:start . 207) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s853.3) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007967@unknown@formal@none@1@S@In this regard, the cytokine interleukin 6 (IL-6) may play a role in the clinical manifestations and pathological events of tuberculosis infection.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 65) (:start . 61)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 81)\n  (:start . 73) (:id . 59))\n ((:tag . "NNS") (:stem . "manifestation") (:form . "manifestations")\n  (:end . 96) (:start . 82) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pathological") (:form . "pathological") (:end . 113)\n  (:start . 101) (:id . 62))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 136)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 146)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x853.4.1) (:span 50 53)))\n (:hscopes ((:id . :x853.4.1) (:span 50 146)))\n (:identifiers (:sid . :s853.4) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007968@unknown@formal@none@1@S@We have demonstrated that lipoarabinomannan (LAM) from the mycobacterial cell wall, which was virtually devoid of lipopolysaccharide (LPS), stimulated mononuclear phagocytes to release IL-6 in a dose-response manner.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lipoarabinomannan") (:form . "lipoarabinomannan")\n  (:end . 43) (:start . 26) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mycobacterial") (:form . "mycobacterial")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "JJ") (:stem . "devoid") (:form . "devoid") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 132) (:start . 114) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 150)\n  (:start . 140) (:id . 66))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 162)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 173)\n  (:start . 163) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "dose-response") (:form . "dose-response")\n  (:end . 208) (:start . 195) (:id . 74))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 215)\n  (:start . 209) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s853.5) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007970@unknown@formal@none@1@S@Both LAM- and LPS-inducible IL-6 promoter activity was localized to a DNA fragment, positions -158 to -49, by deletion analysis and chloramphenicol acetyltransferase assay.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LAM-") (:form . "LAM-") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lps-inducible") (:form . "LPS-inducible")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "CD") (:stem . "-158") (:form . "-158") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-49") (:form . "-49") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 147) (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 165) (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s853.7) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007971@unknown@formal@none@1@S@Two nuclear factor NF-IL6 (positions -153 to -145 and -83 to -75) and one nuclear factor NF-kappa B (positions -72 to -63) motifs are present within this fragment.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "nf-il6") (:form . "NF-IL6") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "-153") (:form . "-153") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-145") (:form . "-145") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-83") (:form . "-83") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "CD") (:stem . "-75") (:form . "-75") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 81)\n  (:start . 74) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 97)\n  (:start . 89) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 110)\n  (:start . 101) (:id . 63))\n ((:tag . "CD") (:stem . "-72") (:form . "-72") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 65))\n ((:tag . "CD") (:stem . "-63") (:form . "-63") (:end . 121) (:start . 118)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 129)\n  (:start . 123) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 133) (:start . 130)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 141)\n  (:start . 134) (:id . 70))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 148)\n  (:start . 142) (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 153) (:start . 149)\n  (:id . 72))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 162)\n  (:start . 154) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s853.8) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007972@unknown@formal@none@1@S@Site-directed mutagenesis of one or more of these motifs within the IL-6 promoter demonstrated that each has positive regulatory activity and that they could act in a function- and orientation-independent manner.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "function-") (:form . "function-") (:end . 176)\n  (:start . 167) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "orientation-independent")\n  (:form . "orientation-independent") (:end . 204) (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 211)\n  (:start . 205) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s853.9) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007973@unknown@formal@none@1@S@Deletion of all three elements abolished inducibility of IL-6 promoter activity by both LAM and LPS.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 53)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s853.10) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007974@unknown@formal@none@1@S@We conclude that the NF-IL6 and NF-kappa B sites mediate IL-6 induction in response to both LPS and LAM, acting as bacterial or mycobacterial response elements.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LAM") (:form . "LAM") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 111)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 124)\n  (:start . 115) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "mycobacterial") (:form . "mycobacterial")\n  (:end . 141) (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s853.11) (:did . :|8134378|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007975@unknown@formal@none@1@S@Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells.@(((:tag . "NNP") (:stem . "Calcineurin") (:form . "Calcineurin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 98)\n  (:start . 92) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "b/ap-1") (:form . "B/AP-1") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s854.1) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007976@unknown@formal@none@1@S@Two cis-acting elements GM-kappa B/GC-box and CLE0, of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate (PMA) and Ca2+ ionophore (A23187).@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "GM-kappa") (:form . "GM-kappa") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "B/GC-box") (:form . "B/GC-box") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 81) (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 100) (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 146)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 156)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 166)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 191) (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 196) (:start . 192)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phorbol-12-myristate")\n  (:form . "phorbol-12-myristate") (:end . 217) (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 225)\n  (:start . 218) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 230) (:start . 227)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 231) (:start . 230)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 240) (:start . 236)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 250)\n  (:start . 241) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 252) (:start . 251)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "A23187") (:form . "A23187") (:end . 258)\n  (:start . 252) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 259) (:start . 258)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s854.2) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007977@unknown@formal@none@1@S@The GM-kappa B sequence is recognized by NF-kappa B, which is mainly induced by PMA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GM-kappa") (:form . "GM-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s854.3) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007978@unknown@formal@none@1@S@The CLE0 sequence interacts with factors, related to a PMA-induced AP-1 and a PMA/A23187-induced NF-AT.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cle0") (:form . "CLE0") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pma/a23187-induced") (:form . "PMA/A23187-induced")\n  (:end . 96) (:start . 78) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s854.4) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007980@unknown@formal@none@1@S@Cotransfection of NF-kappa B (p50/p65)- or AP-1 (c-Jun/c-Fos)- expression vectors into Jurkat cells with a luciferase reporter containing the GM-CSF promoter did not stimulate transcription from the GM-CSF promoter.@(((:tag . "NNP") (:stem . "Cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "p50/p65)-") (:form . "p50/p65)-") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-Jun/c-Fos)-") (:form . "c-Jun/c-Fos)-")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 137)\n  (:start . 127) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 175)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 189) (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 194) (:start . 190)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 205)\n  (:start . 199) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 214)\n  (:start . 206) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x854.6.1) (:span 162 165)))\n (:nscopes ((:id . :x854.6.1) (:span 162 214)))\n (:identifiers (:sid . :s854.6) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007981@unknown@formal@none@1@S@In contrast, cotransfection with a combination of NF-kappa B and AP-1 significantly augmented transcription from the GM-CSF promoter containing the GM-kappa B/GC-box and the CLE0 (AP-1/NF-AT).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 123)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 143)\n  (:start . 133) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GM-kappa") (:form . "GM-kappa") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . "NNP") (:stem . "B/GC-box") (:form . "B/GC-box") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "AP-1/NF-AT") (:form . "AP-1/NF-AT") (:end . 190)\n  (:start . 180) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s854.7) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007982@unknown@formal@none@1@S@Expression of a constitutively active calcineurin (CN), a Ca2+/calmodulin-dependent protein phosphatase, potentiated by two fold the transcriptional activation by NF-kappa B/AP-1.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 30) (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 83) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "potentiate") (:form . "potentiated") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "RB") (:stem . "fold") (:form . "fold") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 148) (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 171)\n  (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "b/ap-1") (:form . "B/AP-1") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s854.8) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007983@unknown@formal@none@1@S@Both constitutively active forms of CN and protein kinase C (PKC) synergistically activated transcription from the GM-CSF promoter.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 81) (:start . 66) (:id . 55))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 121)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s854.9) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007984@unknown@formal@none@1@S@These results suggest that cooperation among NF-kappa B-, AP-1- and NF-AT-binding sequences is required for induction of the GM-CSF gene through PKC- and Ca2+- signaling pathways downstream of T cell activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NNP") (:stem . "B-") (:form . "B-") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-1-") (:form . "AP-1-") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nf-at-binding") (:form . "NF-AT-binding")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "PKC-") (:form . "PKC-") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ca2+-") (:form . "Ca2+-") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 169)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 178)\n  (:start . 170) (:id . 68))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 189)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 210)\n  (:start . 200) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x854.10.1) (:span 14 21)))\n (:hscopes ((:id . :x854.10.1) (:span 14 210)))\n (:identifiers (:sid . :s854.10) (:did . :|8135780|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007985@unknown@formal@none@1@S@Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "5'-CGAAAATTTCC-3") (:form . "5'-CGAAAATTTCC-3")\n  (:end . 109) (:start . 93) (:id . 57))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 138) (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 157)\n  (:start . 145) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 181)\n  (:start . 176) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s855.1) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007986@unknown@formal@none@1@S@The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 41) (:start . 28) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 72)\n  (:start . 65) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 88)\n  (:start . 78) (:id . 59))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 108)\n  (:start . 101) (:id . 62))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 121)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 144)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 154)\n  (:start . 145) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "a23187") (:form . "A23187") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 173)\n  (:start . 167) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 75))\n ((:tag . "VBZ") (:stem . "share") (:form . "shares") (:end . 189)\n  (:start . 183) (:id . 76))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 198)\n  (:start . 190) (:id . 77))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 209)\n  (:start . 199) (:id . 78))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 214) (:start . 210)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 227)\n  (:start . 219) (:id . 81))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 229) (:start . 228)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 233) (:start . 230)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 84))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 243)\n  (:start . 238) (:id . 85))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 251)\n  (:start . 244) (:id . 86))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 257)\n  (:start . 252) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s855.2) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007987@unknown@formal@none@1@S@We examined whether NF(P), a nuclear factor specific for the P sequence, is related to NF-kappa B and NF-AT.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 107)\n  (:start . 102) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x855.3.1) (:span 12 19)))\n (:hscopes ((:id . :x855.3.1) (:span 12 107)))\n (:identifiers (:sid . :s855.3) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007988@unknown@formal@none@1@S@NF-kappa B (P65 or P65/P50 heterodimer) bound to the P sequence in electrophoretic mobility shift assays (EMSA) and activated transcription through the P sequence when expression plasmids were cotransfected with P sequence-driven reporter plasmids in Jurkat T cells.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "P65") (:form . "P65") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "P65/P50") (:form . "P65/P50") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 82) (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 125)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 167) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 178)\n  (:start . 168) (:id . 71))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 187)\n  (:start . 179) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "cotransfecte") (:form . "cotransfected")\n  (:end . 206) (:start . 193) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 211) (:start . 207)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 213) (:start . 212)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "sequence-driven") (:form . "sequence-driven")\n  (:end . 229) (:start . 214) (:id . 77))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 238)\n  (:start . 230) (:id . 78))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 247)\n  (:start . 239) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 250) (:start . 248)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 257)\n  (:start . 251) (:id . 81))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 259) (:start . 258)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 265)\n  (:start . 260) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s855.4) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007990@unknown@formal@none@1@S@Both mobility shift and sequence specificity of NF-AT were similar to those of NF(P) and only a small amount of P65 was detected in NF(P) in crude nuclear extracts.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "P65") (:form . "P65") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "NF(P)") (:form . "NF(P)") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "crude") (:form . "crude") (:end . 146)\n  (:start . 141) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 163)\n  (:start . 155) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s855.6) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007991@unknown@formal@none@1@S@These results indicate that the component(s) of NF-AT has the potential to reconstitute NF(P) whereas NF-kappa B alone cannot account for NF(P) in crude extracts.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "component(s)") (:form . "component(s)") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VB") (:stem . "reconstitute") (:form . "reconstitute") (:end . 87)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "NF(P)") (:form . "NF(P)") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "cannot") (:form . "cannot") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "NF(P)") (:form . "NF(P)") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "crude") (:form . "crude") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 161)\n  (:start . 153) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x855.7.2) (:span 14 27)))\n (:ncues ((:id . :x855.7.1) (:span 119 125)))\n (:hscopes ((:id . :x855.7.2) (:span 14 161)))\n (:nscopes ((:id . :x855.7.1) (:span 119 161)))\n (:identifiers (:sid . :s855.7) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007992@unknown@formal@none@1@S@Unlike NF-AT, NF(P) does not contain AP1 as its DNA binding component.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF(P)") (:form . "NF(P)") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x855.8.1) (:span 25 28)))\n (:nscopes ((:id . :x855.8.1) (:span 25 69)))\n (:identifiers (:sid . :s855.8) (:did . :|8135784|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007993@unknown@formal@none@1@S@Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.@(((:tag . "NNP") (:stem . "Hypoxia") (:form . "Hypoxia") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 83) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s856.1) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5007994@unknown@formal@none@1@S@The response of mammalian cells to stress is controlled by transcriptional regulatory proteins such as nuclear factor kappa B (NF-kappa B) to induce a wide variety of early response genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 74) (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 163)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 187)\n  (:start . 182) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s856.2) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007995@unknown@formal@none@1@S@In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 57)\n  (:start . 50) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "CD") (:stem . "0.02") (:form . "0.02") (:end . 63) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "NN") (:stem . "o2") (:form . "O2") (:end . 67) (:start . 65)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 76)\n  (:start . 69) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 81) (:start . 80)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 87) (:start . 82)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 95) (:start . 90)\n  (:id . 64))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 107)\n  (:start . 96) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 118)\n  (:start . 109) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 127)\n  (:start . 119) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 133) (:start . 130)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 141)\n  (:start . 134) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 150)\n  (:start . 142) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 171) (:start . 156) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 176) (:start . 175)\n  (:id . 77))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 185)\n  (:start . 177) (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 190) (:start . 186)\n  (:id . 79))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 200)\n  (:start . 191) (:id . 80))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 211)\n  (:start . 201) (:id . 81))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 215) (:start . 212)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 224)\n  (:start . 216) (:id . 83))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 226) (:start . 225)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 230) (:start . 227)\n  (:id . 85))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 238)\n  (:start . 231) (:id . 86))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 244)\n  (:start . 239) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s856.3) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007996@unknown@formal@none@1@S@Pretreatment of cells with protein tyrosine kinase inhibitors and the dominant negative allele of c-Raf-1 (Raf 301) inhibited I kappa B alpha degradation, NF-kappa B binding, and transactivation of kappa B reporter constructs by hypoxia.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-raf-1") (:form . "c-Raf-1") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Raf") (:form . "Raf") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "CD") (:stem . "301") (:form . "301") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 153)\n  (:start . 142) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 173)\n  (:start . 166) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 194) (:start . 179) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 203)\n  (:start . 198) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 205) (:start . 204)\n  (:id . 76))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 214)\n  (:start . 206) (:id . 77))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 225)\n  (:start . 215) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 228) (:start . 226)\n  (:id . 79))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 236)\n  (:start . 229) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s856.4) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007997@unknown@formal@none@1@S@To demonstrate a direct link between changes in the phosphorylation pattern of I kappa B alpha with NF-kappa B activation, we immunoprecipitated I kappa B alpha after varying times of hypoxic exposure and found that its tyrosine phosphorylation status increased during hypoxic exposure.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 67) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "immunoprecipitate") (:form . "immunoprecipitated")\n  (:end . 144) (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "VBG") (:stem . "vary") (:form . "varying") (:end . 174)\n  (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 180)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 191)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 200)\n  (:start . 192) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 210)\n  (:start . 205) (:id . 76))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 219) (:start . 216)\n  (:id . 78))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 228)\n  (:start . 220) (:id . 79))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 244) (:start . 229) (:id . 80))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 251)\n  (:start . 245) (:id . 81))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 261)\n  (:start . 252) (:id . 82))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 268)\n  (:start . 262) (:id . 83))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 276)\n  (:start . 269) (:id . 84))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 285)\n  (:start . 277) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s856.5) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5007998@unknown@formal@none@1@S@Inhibition of the transfer of tyrosine phosphoryl groups onto I kappa B alpha prevented I kappa B alpha degradation and NF-kappa B binding.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "phosphoryl") (:form . "phosphoryl") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "onto") (:form . "onto") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 115)\n  (:start . 104) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s856.6) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008000@unknown@formal@none@1@S@These results suggest that tyrosine phosphorylation of I kappa B alpha during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-kappa B.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 51) (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "VBZ") (:stem . "precede") (:form . "precedes") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 147)\n  (:start . 135) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 163)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 177)\n  (:start . 169) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x856.8.1) (:span 14 21)))\n (:hscopes ((:id . :x856.8.1) (:span 14 179)))\n (:identifiers (:sid . :s856.8) (:did . :|8137243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008001@unknown@formal@none@1@S@A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 17) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclease-hypersensitive")\n  (:form . "nuclease-hypersensitive") (:end . 81) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 86) (:start . 82)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pol") (:form . "pol") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 128) (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 139) (:start . 135)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s857.1) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008002@unknown@formal@none@1@S@Analysis of the chromatin organization of the integrated human immunodeficiency virus type 1 (HIV-1) genome has previously revealed a major constitutive DNase I-hypersensitive site associated with the pol gene (E. Verdin, J. Virol. 65:6790-6799, 1991).@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "organization") (:form . "organization") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 79) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 152)\n  (:start . 140) (:id . 64))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "JJ") (:stem . "i-hypersensitive") (:form . "I-hypersensitive")\n  (:end . 175) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 180) (:start . 176)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 191)\n  (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 196) (:start . 192)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 70))\n ((:tag . "NN") (:stem . "pol") (:form . "pol") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 209) (:start . 205)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Verdin") (:form . "Verdin") (:end . 220)\n  (:start . 214) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "J.") (:form . "J.") (:end . 224) (:start . 222)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Virol.") (:form . "Virol.") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . "CD") (:stem . "65:6790-6799") (:form . "65:6790-6799") (:end . 244)\n  (:start . 232) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 80))\n ((:tag . "CD") (:stem . "1991") (:form . "1991") (:end . 250) (:start . 246)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s857.2) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008003@unknown@formal@none@1@S@In the present report, high-resolution mapping of this site with DNase I and micrococcal nuclease identified a nucleosome-free region centered around nucleotides (nt) 4490 to 4766.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high-resolution") (:form . "high-resolution")\n  (:end . 38) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "micrococcal") (:form . "micrococcal") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "nuclease") (:form . "nuclease") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nucleosome-free") (:form . "nucleosome-free")\n  (:end . 126) (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 142)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 161)\n  (:start . 150) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nt") (:form . "nt") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "CD") (:stem . "4490") (:form . "4490") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "CD") (:stem . "4766") (:form . "4766") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s857.3) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008004@unknown@formal@none@1@S@A 500-bp fragment encompassing this hypersensitive site (nt 4481 to 4982) exhibited transcription-enhancing activity (two- to threefold) when it was cloned in its natural position with respect to the HIV-1 promoter after transient transfection in U937 and CEM cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "500-bp") (:form . "500-bp") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 50) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "nt") (:form . "nt") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "CD") (:stem . "4481") (:form . "4481") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4982") (:form . "4982") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "JJ") (:stem . "transcription-enhancing")\n  (:form . "transcription-enhancing") (:end . 107) (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "threefold") (:form . "threefold") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 170)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 192)\n  (:start . 185) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 195) (:start . 193)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 205)\n  (:start . 200) (:id . 75))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 220)\n  (:start . 215) (:id . 77))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 230)\n  (:start . 221) (:id . 78))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 243)\n  (:start . 231) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 246) (:start . 244)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "U937") (:form . "U937") (:end . 251) (:start . 247)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 255) (:start . 252)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 259) (:start . 256)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 265)\n  (:start . 260) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s857.4) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008005@unknown@formal@none@1@S@Using in vitro footprinting and gel shift assays, we have identified four distinct binding sites for nuclear proteins within this positive regulatory element.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s857.5) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008006@unknown@formal@none@1@S@Site B (nt 4519 to 4545) specifically bound four distinct nuclear protein complexes: a ubiquitous factor, a T-cell-specific factor, a B-cell-specific factor, and the monocyte/macrophage- and B-cell-specific transcription factor PU.1/Spi-1.@(((:tag . "NN") (:stem . "site") (:form . "Site") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "nt") (:form . "nt") (:end . 10) (:start . 8)\n  (:id . 45))\n ((:tag . "CD") (:stem . "4519") (:form . "4519") (:end . 15) (:start . 11)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 47))\n ((:tag . "CD") (:stem . "4545") (:form . "4545") (:end . 23) (:start . 19)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 37)\n  (:start . 25) (:id . 50))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 48) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 57)\n  (:start . 49) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "t-cell-specific") (:form . "T-cell-specific")\n  (:end . 123) (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 149) (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 156)\n  (:start . 150) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "monocyte/macrophage-")\n  (:form . "monocyte/macrophage-") (:end . 186) (:start . 166) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 206) (:start . 191) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 220) (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 227)\n  (:start . 221) (:id . 76))\n ((:tag . "NN") (:stem . "pu.1/spi-1") (:form . "PU.1/Spi-1") (:end . 238)\n  (:start . 228) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s857.6) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008007@unknown@formal@none@1@S@In most HIV-1 isolates in which this PU box was not conserved, it was replaced by a binding site for the related factor Ets1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PU") (:form . "PU") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 61)\n  (:start . 52) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 78)\n  (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 91)\n  (:start . 84) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 112)\n  (:start . 105) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 65))\n ((:tag . "NN") (:stem . "ets1") (:form . "Ets1") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x857.7.1) (:span 48 51)))\n (:nscopes ((:id . :x857.7.1) (:span 32 61)))\n (:identifiers (:sid . :s857.7) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008008@unknown@formal@none@1@S@Factors binding to site C (nt 4681 to 4701) had a DNA-binding specificity similar to that of factors binding to site B, except for PU.1/Spi-1.@(((:tag . "NNS") (:stem . "factor") (:form . "Factors") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 15) (:start . 8)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "nt") (:form . "nt") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "CD") (:stem . "4681") (:form . "4681") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "CD") (:stem . "4701") (:form . "4701") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 47) (:start . 44)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 61)\n  (:start . 50) (:id . 55))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 73)\n  (:start . 62) (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 100)\n  (:start . 93) (:id . 61))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 118) (:start . 117)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 66))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 126)\n  (:start . 120) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pu.1/spi-1") (:form . "PU.1/Spi-1") (:end . 141)\n  (:start . 131) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s857.8) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008010@unknown@formal@none@1@S@Site D (nt 4816 to 4851) specifically bound a ubiquitously expressed factor.@(((:tag . "NN") (:stem . "site") (:form . "Site") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "nt") (:form . "nt") (:end . 10) (:start . 8)\n  (:id . 45))\n ((:tag . "CD") (:stem . "4816") (:form . "4816") (:end . 15) (:start . 11)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 47))\n ((:tag . "CD") (:stem . "4851") (:form . "4851") (:end . 23) (:start . 19)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 37)\n  (:start . 25) (:id . 50))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 58)\n  (:start . 46) (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s857.10) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008011@unknown@formal@none@1@S@These results identify a transcriptional regulatory element associated with a nuclease-hypersensitive site in the pol gene of HIV-1 and suggest that its activity may be controlled by a complex interplay of cis-regulatory elements.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclease-hypersensitive")\n  (:form . "nuclease-hypersensitive") (:end . 101) (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 106) (:start . 102)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pol") (:form . "pol") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 131)\n  (:start . 126) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 143)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 161)\n  (:start . 153) (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 165) (:start . 162)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 179)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 192)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 202)\n  (:start . 193) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 220) (:start . 206) (:id . 73))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 229)\n  (:start . 221) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x857.11.1) (:span 162 165))\n  ((:id . :x857.11.2) (:span 136 143)))\n (:hscopes ((:id . :x857.11.1) (:span 162 229))\n  ((:id . :x857.11.2) (:span 136 229)))\n (:identifiers (:sid . :s857.11) (:did . :|8139041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008012@unknown@formal@none@1@S@Expression of v-src in T cells correlates with nuclear expression of NF-kappa B.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "v-src") (:form . "v-src") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s858.1) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008013@unknown@formal@none@1@S@NF-kappa B is a rapidly inducible transcriptional activator that responds to a variety of signals and influences the expression of many genes involved in the immune response.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 49) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s858.2) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008014@unknown@formal@none@1@S@Protein tyrosine kinases transmit signals from cytokine and immune receptors.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "transmit") (:form . "transmit") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s858.3) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008015@unknown@formal@none@1@S@Very little information exists linking these two important classes of signaling molecules.@(((:tag . "RB") (:stem . "very") (:form . "Very") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VBG") (:stem . "link") (:form . "linking") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s858.4) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008016@unknown@formal@none@1@S@We now demonstrate that v-src expression correlates with nuclear expression of a kappa B binding complex similar to that induced by phorbol ester and ionomycin, as detected by electrophoretic mobility shift assay using a variety of kappa B sites.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "v-src") (:form . "v-src") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 159)\n  (:start . 150) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 191) (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 206)\n  (:start . 201) (:id . 73))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 212)\n  (:start . 207) (:id . 74))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 218) (:start . 213)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 228)\n  (:start . 221) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 78))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 237)\n  (:start . 232) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 239) (:start . 238)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 245)\n  (:start . 240) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s858.5) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008017@unknown@formal@none@1@S@This complex was blocked by the tyrosine kinase inhibitor, herbimycin A.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s858.6) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008018@unknown@formal@none@1@S@The v-src-induced complex comprised the p50 and p65 components of NF-kappa B, as determined by supershift and immunoblot analysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "v-src-induced") (:form . "v-src-induced")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "comprise") (:form . "comprised") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "immunoblot") (:form . "immunoblot") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s858.7) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008020@unknown@formal@none@1@S@We found that transactivation of the HIV-1 LTR by v-src was more sensitive to mutations of the proximal, rather than the distal, kappa B element.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 29) (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "v-src") (:form . "v-src") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 144)\n  (:start . 137) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x858.9.1) (:span 105 116)))\n (:nscopes ((:id . :x858.9.1) (:span 105 127)))\n (:identifiers (:sid . :s858.9) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008021@unknown@formal@none@1@S@The implications for T cell receptor signaling and HIV-1 gene expression are considered.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s858.10) (:did . :|8144878|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008022@unknown@formal@none@1@S@Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nef") (:form . "Nef") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "down-regulate") (:form . "down-regulates")\n  (:end . 62) (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 93)\n  (:start . 85) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 164)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s859.1) (:did . :|8151786|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008023@unknown@formal@none@1@S@Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) has been shown to down-regulate the transcription factors NF-kappa B and AP-1 in vitro.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "VB") (:stem . "down-regulate") (:form . "down-regulate")\n  (:end . 97) (:start . 84) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s859.2) (:did . :|8151786|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008024@unknown@formal@none@1@S@To define the mechanism of action of the Nef protein, the signal transduction pathways which may be affected in T cells by constitutive expression of the nef gene were examined.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 77)\n  (:start . 65) (:id . 55))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 135)\n  (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 162) (:start . 158)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 176)\n  (:start . 168) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x859.3.1) (:span 93 96)))\n (:hscopes ((:id . :x859.3.1) (:span 87 176)))\n (:identifiers (:sid . :s859.3) (:did . :|8151786|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008025@unknown@formal@none@1@S@Stimulation of T cells with tumor necrosis factor, interleukin-1, or lipopolysaccharide resulted in the recruitment of transcriptional factors to a similar level whether or not the cells expressed the nef gene.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 87) (:start . 69) (:id . 54))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 115)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 134) (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 142)\n  (:start . 135) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 196)\n  (:start . 187) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x859.4.1) (:span 162 176)))\n (:hscopes ((:id . :x859.4.1) (:span 162 209)))\n (:identifiers (:sid . :s859.4) (:did . :|8151786|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008026@unknown@formal@none@1@S@On the other hand, stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex resulted in the down-regulation of transcriptional factors NF-kappa B and AP-1 in cells expressing the nef gene compared with cells not expressing the nef gene.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "mitogen") (:form . "mitogens") (:end . 53)\n  (:start . 45) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 67)\n  (:start . 57) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "TCR)-CD3") (:form . "TCR)-CD3") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 140) (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 159) (:start . 144) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 176)\n  (:start . 168) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 187) (:start . 183)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 207)\n  (:start . 197) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 76))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 215) (:start . 212)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 229)\n  (:start . 221) (:id . 79))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 234) (:start . 230)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 240)\n  (:start . 235) (:id . 81))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 244) (:start . 241)\n  (:id . 82))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 255)\n  (:start . 245) (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 259) (:start . 256)\n  (:id . 84))\n ((:tag . "NN") (:stem . "nef") (:form . "nef") (:end . 263) (:start . 260)\n  (:id . 85))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 268) (:start . 264)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x859.5.1) (:span 241 244)))\n (:nscopes ((:id . :x859.5.1) (:span 241 268)))\n (:identifiers (:sid . :s859.5) (:did . :|8151786|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008027@unknown@formal@none@1@S@Because the Nef protein does not affect the surface expression of the CD3-TCR complex, we conclude that the Nef protein down-regulates the transcriptional factors NF-kappa B and AP-1 in T cells in vitro through an effect on the TCR-dependent signal transduction pathway.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD3-TCR") (:form . "CD3-TCR") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Nef") (:form . "Nef") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "VBZ") (:stem . "down-regulate") (:form . "down-regulates")\n  (:end . 134) (:start . 120) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 154) (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 182) (:start . 178)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 193)\n  (:start . 188) (:id . 73))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 74))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 202)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 210)\n  (:start . 203) (:id . 76))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 213) (:start . 211)\n  (:id . 77))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 220)\n  (:start . 214) (:id . 78))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 223) (:start . 221)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "tcr-dependent") (:form . "TCR-dependent")\n  (:end . 241) (:start . 228) (:id . 81))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 248)\n  (:start . 242) (:id . 82))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 261)\n  (:start . 249) (:id . 83))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 269)\n  (:start . 262) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x859.6.1) (:span 29 32)))\n (:nscopes ((:id . :x859.6.1) (:span 29 85)))\n (:identifiers (:sid . :s859.6) (:did . :|8151786|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008028@unknown@formal@none@1@S@Activation of nuclear factor kappa B in human neuroblastoma cell lines.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s860.1) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008030@unknown@formal@none@1@S@In B cells and macrophages it is constitutively present in cell nuclei, whereas in many other cell types, NF-kappa B translocates from cytosol to nucleus as a result of transduction by tumor necrosis factor alpha (TNF alpha), phorbol ester, and other polyclonal signals.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . 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"TNF") (:end . 217) (:start . 214)\n  (:id . 80))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 223)\n  (:start . 218) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 83))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 233)\n  (:start . 226) (:id . 84))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 239)\n  (:start . 234) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 240) (:start . 239)\n  (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 244) (:start . 241)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 250)\n  (:start . 245) (:id . 88))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 261)\n  (:start . 251) (:id . 89))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 269)\n  (:start . 262) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s860.3) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008031@unknown@formal@none@1@S@Using neuroblastoma cell lines as models, we have shown that in neural cells NF-kappa B was present in the cytosol and translocated into nuclei as a result of TNF alpha treatment.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neural") (:form . "neural") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 131)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 155)\n  (:start . 149) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 162) (:start . 159)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 168)\n  (:start . 163) (:id . 72))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 178)\n  (:start . 169) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s860.4) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008032@unknown@formal@none@1@S@The TNF alpha-activated NF-kappa B was transcriptionally functional.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "alpha-activated") (:form . "alpha-activated")\n  (:end . 23) (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 56) (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s860.5) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008033@unknown@formal@none@1@S@NF-kappa B activation by TNF alpha was not correlated with cell differentiation or proliferation.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 79) (:start . 64) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 96) (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x860.6.1) (:span 39 42)))\n (:nscopes ((:id . :x860.6.1) (:span 0 96)))\n (:identifiers (:sid . :s860.6) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008034@unknown@formal@none@1@S@However, reagents such as nerve growth factor (NGF) and the phorbol ester phorbol 12-myristate 13-acetate (PMA), which induce phenotypical differentiation of the SH-SY5Y neuroblastoma cell line, activated NF-kappa B, but only in that particular cell line.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "reagent") (:form . "reagents") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nerve") (:form . "nerve") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NGF") (:form . "NGF") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 67)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 94)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 125)\n  (:start . 119) (:id . 65))\n ((:tag . "JJ") (:stem . "phenotypical") (:form . "phenotypical") (:end . 138)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 154) (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "sh-sy5y") (:form . "SH-SY5Y") (:end . 169)\n  (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 183) (:start . 170) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 204)\n  (:start . 195) (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 213)\n  (:start . 205) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 220) (:start . 217)\n  (:id . 79))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 81))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 233) (:start . 229)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 244)\n  (:start . 234) (:id . 83))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 249) (:start . 245)\n  (:id . 84))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 254) (:start . 250)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s860.7) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008035@unknown@formal@none@1@S@In a NGF-responsive rat pheochromocytoma cell line, PC12, PMA activated NF-kappa B, whereas NGF did not.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "ngf-responsive") (:form . "NGF-responsive")\n  (:end . 19) (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pheochromocytoma") (:form . "pheochromocytoma")\n  (:end . 40) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PC12") (:form . "PC12") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "NNP") (:stem . "NGF") (:form . "NGF") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x860.8.1) (:span 100 103)))\n (:nscopes ((:id . :x860.8.1) (:span 100 103)))\n (:identifiers (:sid . :s860.8) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008036@unknown@formal@none@1@S@In other neuroblastoma cell lines, such as SK-N-Be(2), the lack of PMA induction of differentiation was correlated with the lack of NF-kappa B activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SK-N-Be(2)") (:form . "SK-N-Be(2)") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 99) (:start . 84) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x860.9.1) (:span 124 128))\n  ((:id . :x860.9.2) (:span 59 63)))\n (:nscopes ((:id . :x860.9.1) (:span 124 153))\n  ((:id . :x860.9.2) (:span 59 99)))\n (:identifiers (:sid . :s860.9) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008037@unknown@formal@none@1@S@We found, moreover, that in SK-N-Be(2) cells protein kinase C (PKC) enzymatic activity was much lower compared with that in a control cell line and that the low PKC enzymatic activity was due to low PKC protein expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "moreover") (:form . "moreover") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "SK-N-Be(2)") (:form . "SK-N-Be(2)") (:end . 38)\n  (:start . 28) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 77)\n  (:start . 68) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 101) (:start . 96)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 110)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 133)\n  (:start . 126) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 143) (:start . 139)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 160) (:start . 157)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 164) (:start . 161)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 174)\n  (:start . 165) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 183)\n  (:start . 175) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 187) (:start . 184)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 191) (:start . 188)\n  (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 198) (:start . 195)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 202) (:start . 199)\n  (:id . 81))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 210)\n  (:start . 203) (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s860.10) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008038@unknown@formal@none@1@S@NF-kappa B was not activated by retinoic acid, which induced morphological differentiation of all the neuroblastoma cell lines used in the present study.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "morphological") (:form . "morphological")\n  (:end . 74) (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 90) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x860.11.1) (:span 15 18)))\n (:nscopes ((:id . :x860.11.1) (:span 0 45)))\n (:identifiers (:sid . :s860.11) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008040@unknown@formal@none@1@S@Furthermore, the results obtained with TNF alpha proved that NF-kappa B activation was not sufficient for induction of neuroblastoma differentiation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "prove") (:form . "proved") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "neuroblastoma") (:form . "neuroblastoma")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 148) (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x860.13.1) (:span 87 90)))\n (:nscopes ((:id . :x860.13.1) (:span 87 148)))\n (:identifiers (:sid . :s860.13) (:did . :|8158122|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008041@unknown@formal@none@1@S@A novel heterodimerization partner for thyroid hormone receptor.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "heterodimerization") (:form . "heterodimerization")\n  (:end . 26) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s861.1) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008042@unknown@formal@none@1@S@Peroxisome proliferator-activated receptor.@(((:tag . "NNP") (:stem . "Peroxisome") (:form . "Peroxisome") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "proliferator-activated")\n  (:form . "proliferator-activated") (:end . 33) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 42)\n  (:start . 34) (:id . 44))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s861.2) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008043@unknown@formal@none@1@S@Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors.@(((:tag . "JJ") (:stem . "retinoid-like") (:form . "Retinoid-like")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hormonal") (:form . "hormonal") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "form") (:form . "forming") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s861.3) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008044@unknown@formal@none@1@S@In this study we have identified the peroxisome proliferator-activated receptor (PPAR) as a new thyroid hormone receptor (THR) auxiliary nuclear protein, heterodimerizing with THR in solution.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "peroxisome") (:form . "peroxisome") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "proliferator-activated")\n  (:form . "proliferator-activated") (:end . 70) (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PPAR") (:form . "PPAR") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "THR") (:form . "THR") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "auxiliary") (:form . "auxiliary") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "heterodimerize") (:form . "heterodimerizing")\n  (:end . 170) (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "THR") (:form . "THR") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 191)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s861.4) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008045@unknown@formal@none@1@S@Although these heterodimers do not recognize a classical thyroid hormone response element (TRE) characterized by direct repeat separated by four nucleotides (DR+4), PPAR behaves as a dominant negative regulator of thyroid hormone (TH) action.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "recognize") (:form . "recognize") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 109) (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 156)\n  (:start . 145) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DR+4") (:form . "DR+4") (:end . 162) (:start . 158)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PPAR") (:form . "PPAR") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "behave") (:form . "behaves") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 180) (:start . 178)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 182) (:start . 181)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 191)\n  (:start . 183) (:id . 73))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 200)\n  (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 210)\n  (:start . 201) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 76))\n ((:tag . "NN") (:stem . "thyroid") (:form . "thyroid") (:end . 221)\n  (:start . 214) (:id . 77))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 229)\n  (:start . 222) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "TH") (:form . "TH") (:end . 233) (:start . 231)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 81))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 241)\n  (:start . 235) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x861.5.1) (:span 31 34)))\n (:nscopes ((:id . :x861.5.1) (:span 31 163)))\n (:identifiers (:sid . :s861.5) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008046@unknown@formal@none@1@S@However, a TH-dependent positive effect is elicited by selective interaction of the THR beta-PPAR but not the THR alpha-PPAR heterodimer with a novel TRE (DR+2).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "th-dependent") (:form . "TH-dependent") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "THR") (:form . "THR") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "beta-PPAR") (:form . "beta-PPAR") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "THR") (:form . "THR") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "alpha-PPAR") (:form . "alpha-PPAR") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 136)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "dr+2") (:form . "DR+2") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x861.6.1) (:span 102 105)))\n (:nscopes ((:id . :x861.6.1) (:span 102 160)))\n (:identifiers (:sid . :s861.6) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008047@unknown@formal@none@1@S@The critical region of THR beta was mapped to 3 amino acids in the distal box of the DNA binding domain.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "THR") (:form . "THR") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 42) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 103)\n  (:start . 97) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s861.7) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008048@unknown@formal@none@1@S@Hence, PPAR can positively or negatively influence TH action depending on TRE structure and THR isotype.@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "PPAR") (:form . "PPAR") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "th") (:form . "TH") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tre") (:form . "TRE") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "THR") (:form . "THR") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s861.8) (:did . :|8163464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008050@unknown@formal@none@1@S@Because leukocyte-mediated tissue damage is an important component of the pathologic picture in ischemia/reperfusion, we have sought mechanisms by which PMNs are directed into hypoxic tissue.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "leukocyte-mediated") (:form . "leukocyte-mediated")\n  (:end . 26) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 33)\n  (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 40)\n  (:start . 34) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pathologic") (:form . "pathologic") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "picture") (:form . "picture") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ischemia/reperfusion")\n  (:form . "ischemia/reperfusion") (:end . 116) (:start . 96) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "seek") (:form . "sought") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . "NNS") (:stem . "pmn") (:form . "PMNs") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 161) (:start . 158)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 170)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 183)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 190)\n  (:start . 184) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s862.2) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008051@unknown@formal@none@1@S@Incubation of human endothelial cells (ECs) in hypoxia, PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs, blocked by antibody to IL-8.@(((:tag . "NN") (:stem . "incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EC") (:form . "ECs") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PO2") (:form . "PO2") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 73) (:start . 60) (:id . 54))\n ((:tag . "CD") (:stem . "14-18") (:form . "14-18") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Torr") (:form . "Torr") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 107) (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "condition") (:form . "conditioned") (:end . 152)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 181)\n  (:start . 170) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 194)\n  (:start . 185) (:id . 74))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 206)\n  (:start . 195) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 215)\n  (:start . 207) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMNs") (:end . 224) (:start . 220)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 233)\n  (:start . 226) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 236) (:start . 234)\n  (:id . 81))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 245)\n  (:start . 237) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 248) (:start . 246)\n  (:id . 83))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 253) (:start . 249)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s862.3) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008052@unknown@formal@none@1@S@Production of IL-8 by hypoxic ECs occurred concomitantly with both increased levels of IL-8 mRNA, based on polymerase chain reaction analysis, and increased IL-8 transcription, based on nuclear run-on assays.@(((:tag . "NN") (:stem . "production") (:form . "Production") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 207)\n  (:start . 201) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s862.4) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008053@unknown@formal@none@1@S@Northern analysis of mRNA from hypoxic ECs also demonstrated increased levels of mRNA for macrophage chemotactic protein-1, another member of the chemokine superfamily of proinflammatory cytokines.@(((:tag . "JJ") (:stem . "northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 167)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 186) (:start . 171) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 196)\n  (:start . 187) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s862.5) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008054@unknown@formal@none@1@S@IL-8 gene induction was associated with the presence of increased binding activity in nuclear extracts from hypoxic ECs for the NF-kB site.@(((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "ec") (:form . "ECs") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s862.6) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008055@unknown@formal@none@1@S@Studies with human umbilical vein segments exposed to hypoxia also demonstrated increased elaboration of IL-8 antigen compared with normoxic controls.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 79)\n  (:start . 67) (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "elaboration") (:form . "elaboration") (:end . 101)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "normoxic") (:form . "normoxic") (:end . 140)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 149)\n  (:start . 141) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s862.7) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008056@unknown@formal@none@1@S@In mice exposed to hypoxia (PO2 approximately 30-40 Torr), there was increased pulmonary leukostasis, as evidenced by increased myeloperoxidase activity in tissue homogenates.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PO2") (:form . "PO2") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 45) (:start . 32) (:id . 49))\n ((:tag . "CD") (:stem . "30-40") (:form . "30-40") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Torr") (:form . "Torr") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "leukostasis") (:form . "leukostasis") (:end . 100)\n  (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "myeloperoxidase") (:form . "myeloperoxidase")\n  (:end . 143) (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 162)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "homogenate") (:form . "homogenates") (:end . 174)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s862.8) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008057@unknown@formal@none@1@S@In parallel, increased levels of transcripts for IP-10, a murine homologue in the chemokine family related to IL-8, were observed in hypoxic lung tissue.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IP-10") (:form . "IP-10") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "hypoxic") (:form . "hypoxic") (:end . 140)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s862.9) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008058@unknown@formal@none@1@S@Taken together, these data suggest that hypoxia constitutes a stimulus for leukocyte chemotaxis and tissue leukostasis.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "constitute") (:form . "constitutes") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "chemotaxis") (:form . "chemotaxis") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "leukostasis") (:form . "leukostasis") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x862.10.1) (:span 27 34)))\n (:hscopes ((:id . :x862.10.1) (:span 27 118)))\n (:identifiers (:sid . :s862.10) (:did . :|8163658|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008060@unknown@formal@none@1@S@The promoter of the human major histocompatibility complex class II-associated invariant-chain gene (Ii) contains two NF-kappa B/Rel binding sites located at -109 to -118 (Ii kappa B-1) and -163 to -172 (Ii kappa B-2) from the transcription start site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 50) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ii-associated") (:form . "II-associated")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "JJ") (:stem . "invariant-chain") (:form . "invariant-chain")\n  (:end . 94) (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ii") (:form . "Ii") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 126)\n  (:start . 118) (:id . 59))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-109") (:form . "-109") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-118") (:form . "-118") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ii") (:form . "Ii") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "b-1") (:form . "B-1") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "CD") (:stem . "-163") (:form . "-163") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 75))\n ((:tag . "CD") (:stem . "-172") (:form . "-172") (:end . 202) (:start . 198)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 204) (:start . 203)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Ii") (:form . "Ii") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 212)\n  (:start . 207) (:id . 79))\n ((:tag . "NN") (:stem . "b-2") (:form . "B-2") (:end . 216) (:start . 213)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 217) (:start . 216)\n  (:id . 81))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 222) (:start . 218)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 83))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 240) (:start . 227) (:id . 84))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 246)\n  (:start . 241) (:id . 85))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 251) (:start . 247)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s863.2) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008061@unknown@formal@none@1@S@We report here that the differential function of each of these NF-kappa B/Rel sites in several distinct cell types depends on cell-specific binding of NF-kappa B/Rel transcription factors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 139) (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s863.3) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008062@unknown@formal@none@1@S@Ii kappa B-1 is a positive regulatory element in B-cell lines and in the Ii-expressing T-cell line, H9, but acts as a negative regulatory element in myelomonocytic and glia cell lines.@(((:tag . "NNP") (:stem . "Ii") (:form . "Ii") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "b-1") (:form . "B-1") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ii-expressing") (:form . "Ii-expressing")\n  (:end . 86) (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 126)\n  (:start . 118) (:id . 66))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 137)\n  (:start . 127) (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 145)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 163) (:start . 149) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "glia") (:form . "glia") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 177) (:start . 173)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 183)\n  (:start . 178) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s863.4) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008063@unknown@formal@none@1@S@In vivo protein-DNA contacts are detectable at Ii kappa B-1 in cell lines in which this site is functional as either a positive or negative regulator.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "contact") (:form . "contacts") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ii") (:form . "Ii") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b-1") (:form . "B-1") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 127)\n  (:start . 119) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s863.5) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008064@unknown@formal@none@1@S@Electrophoretic mobility supershift assays determine that members of the NF-kappa B/Rel family of transcription factors can bind to this site in vitro and that DNA-binding complexes that contain p50, p52, p65, and cRel correlate with positive regulation whereas the presence of p50 correlates with negative regulation.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 35)\n  (:start . 25) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 42)\n  (:start . 36) (:id . 45))\n ((:tag . "VBP") (:stem . "determine") (:form . "determine") (:end . 52)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 47))\n ((:tag . "NNS") (:stem . 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"negative") (:form . "negative") (:end . 306)\n  (:start . 298) (:id . 89))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 317)\n  (:start . 307) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 318) (:start . 317)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s863.6) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008065@unknown@formal@none@1@S@Ii kappa B-2 is a site of positive regulation in B-cell lines and a site of negative regulation in H9 T cells, myelomonocytic, and glial cell lines.@(((:tag . "NNP") (:stem . "Ii") (:form . "Ii") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B-2") (:form . "B-2") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 34)\n  (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 95)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 125) (:start . 111) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 136)\n  (:start . 131) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 141) (:start . 137)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 147)\n  (:start . 142) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s863.7) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008066@unknown@formal@none@1@S@In vivo occupancy of this site is observed only in the H9 T-cell line.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "H9") (:form . "H9") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s863.8) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008067@unknown@formal@none@1@S@Again, in vitro supershift studies indicate that the presence of p50, p52, p65, and cRel correlates with positive function whereas the presence of only p50 and p52 correlates with negative function.@(((:tag . "RB") (:stem . "again") (:form . "Again") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "crel") (:form . "cRel") (:end . 88) (:start . 84)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 99)\n  (:start . 89) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 113)\n  (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 155) (:start . 152)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 174)\n  (:start . 164) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 188)\n  (:start . 180) (:id . 75))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 197)\n  (:start . 189) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x863.9.1) (:span 35 48)))\n (:hscopes ((:id . :x863.9.1) (:span 35 197)))\n (:identifiers (:sid . :s863.9) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008068@unknown@formal@none@1@S@This differential binding of specific NF-kappa B/Rel subunits is likely to mediate the disparate functions of these two NF-kappa B/Rel binding sites.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "disparate") (:form . "disparate") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 148)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x863.10.1) (:span 65 71)))\n (:hscopes ((:id . :x863.10.1) (:span 0 148)))\n (:identifiers (:sid . :s863.10) (:did . :|8164652|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008070@unknown@formal@none@1@S@The zinc finger transcription factor GATA-1 is a major regulator of gene expression in erythroid, megakaryocyte, and mast cell lineages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "megakaryocyte") (:form . "megakaryocyte")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s864.2) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008071@unknown@formal@none@1@S@GATA-1 binds to WGATAR consensus motifs in the regulatory regions of virtually all erythroid cell-specific genes.@(((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "WGATAR") (:form . "WGATAR") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s864.3) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008072@unknown@formal@none@1@S@Analyses with cultured cells and cell-free systems have provided strong evidence that GATA-1 is involved in control of globin gene expression during erythroid differentiation.@(((:tag . "NNS") (:stem . "analysis") (:form . "Analyses") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 174) (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s864.4) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008073@unknown@formal@none@1@S@Targeted mutagenesis of the GATA-1 gene in embryonic stem cells has demonstrated its requirement in normal erythroid development.@(((:tag . "VBN") (:stem . "target") (:form . "Targeted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 128)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s864.5) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008074@unknown@formal@none@1@S@Efficient rescue of the defect requires an intact GATA element in the distal promoter, suggesting autoregulatory control of GATA-1 transcription.@(((:tag . "JJ") (:stem . "efficient") (:form . "Efficient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 112) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x864.6.1) (:span 87 97)))\n (:hscopes ((:id . :x864.6.1) (:span 87 144)))\n (:identifiers (:sid . :s864.6) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008075@unknown@formal@none@1@S@To examine whether GATA-1 expression involves additional regulatory factors or is maintained entirely by an autoregulatory loop, we have used a transient heterokaryon system to test the ability of erythroid factors to activate the GATA-1 gene in nonerythroid nuclei.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 75)\n  (:start . 68) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "RB") (:stem . "entirely") (:form . "entirely") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 122) (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "heterokaryon") (:form . "heterokaryon") (:end . 166)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 173)\n  (:start . 167) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 193)\n  (:start . 186) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 206)\n  (:start . 197) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 214)\n  (:start . 207) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 226)\n  (:start . 218) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 237)\n  (:start . 231) (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 242) (:start . 238)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 245) (:start . 243)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "nonerythroid") (:form . "nonerythroid") (:end . 258)\n  (:start . 246) (:id . 80))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 265)\n  (:start . 259) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x864.7.1) (:span 76 78)) ((:id . :x864.7.2) (:span 11 18)))\n (:hscopes ((:id . :x864.7.1) (:span 37 127))\n  ((:id . :x864.7.2) (:span 11 127)))\n (:identifiers (:sid . :s864.7) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008076@unknown@formal@none@1@S@We show here that proerythroblasts and mature erythroid cells contain a diffusible activity (TAG) capable of transcriptional activation of GATA-1 and that this activity decreases during the terminal differentiation of erythroid cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "proerythroblast") (:form . "proerythroblasts")\n  (:end . 34) (:start . 18) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "diffusible") (:form . "diffusible") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TAG") (:form . "TAG") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 124) (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 178)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 185)\n  (:start . 179) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 198)\n  (:start . 190) (:id . 71))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 214) (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 227)\n  (:start . 218) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 233)\n  (:start . 228) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s864.8) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008077@unknown@formal@none@1@S@Nuclei from GATA-1- mutant embryonic stem cells can still be reprogrammed to express their globin genes in erythroid heterokaryons, indicating that de novo induction of GATA-1 is not required for globin gene activation following cell fusion.@(((:tag . "NNP") (:stem . "Nucleus") (:form . "Nuclei") (:end . 6)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gata-1-") (:form . "GATA-1-") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reprogramme") (:form . "reprogrammed") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 90)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "heterokaryon") (:form . "heterokaryons")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 165)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 175)\n  (:start . 169) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 191)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 202)\n  (:start . 196) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 218)\n  (:start . 208) (:id . 75))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 228)\n  (:start . 219) (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 233) (:start . 229)\n  (:id . 77))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 240)\n  (:start . 234) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x864.9.2) (:span 132 147)))\n (:ncues ((:id . :x864.9.1) (:span 179 182)))\n (:hscopes ((:id . :x864.9.2) (:span 132 240)))\n (:nscopes ((:id . :x864.9.1) (:span 148 240)))\n (:identifiers (:sid . :s864.9) (:did . :|8164666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008078@unknown@formal@none@1@S@Functional block for 1 alpha,25-dihydroxyvitamin D3-mediated gene regulation in human B lymphocytes.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha,25-dihydroxyvitamin")\n  (:form . "alpha,25-dihydroxyvitamin") (:end . 48) (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "d3-mediated") (:form . "D3-mediated") (:end . 60)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 76)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 99)\n  (:start . 88) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s865.1) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008080@unknown@formal@none@1@S@These parameters were examined in normal and Epstein-Barr virus-immortalized human B cells and compared with 1 alpha,25-(OH)2D3-responsive cells of the T and monocytic lineages.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "virus-immortalized") (:form . "virus-immortalized")\n  (:end . 76) (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "alpha,25-(OH)2D3-responsive")\n  (:form . "alpha,25-(OH)2D3-responsive") (:end . 138) (:start . 111)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 153) (:start . 152)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 167)\n  (:start . 158) (:id . 64))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 176)\n  (:start . 168) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s865.3) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008081@unknown@formal@none@1@S@Although resting tonsillar B cells did not express VDR mRNA, activation of these cells with interleukin-4 induced VDR in the absence of exogenously supplemented 1 alpha,25-(OH)2D3.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 16) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "tonsillar") (:form . "tonsillar") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 105) (:start . 92) (:id . 58))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "RB") (:stem . "exogenously") (:form . "exogenously") (:end . 147)\n  (:start . 136) (:id . 65))\n ((:tag . "VBN") (:stem . "supplement") (:form . "supplemented") (:end . 160)\n  (:start . 148) (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 179) (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x865.4.1) (:span 125 132))\n  ((:id . :x865.4.2) (:span 39 42)))\n (:nscopes ((:id . :x865.4.1) (:span 125 179))\n  ((:id . :x865.4.2) (:span 39 59)))\n (:identifiers (:sid . :s865.4) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008082@unknown@formal@none@1@S@As indicators of hormone-mediated gene regulation we analyzed modulation of CD23, a common B cell/monocyte surface antigen, and 24-hydroxylase.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "indicator") (:form . "indicators") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hormone-mediated") (:form . "hormone-mediated")\n  (:end . 33) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell/monocyte") (:form . "cell/monocyte")\n  (:end . 106) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "24-hydroxylase") (:form . "24-hydroxylase")\n  (:end . 142) (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s865.5) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008083@unknown@formal@none@1@S@1 alpha,25-(OH)2D3 inhibited CD23 expression in U937 cells, yet failed to modulate CD23 expression in B cells.@(((:tag . "CD") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 18) (:start . 2) (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 70) (:start . 64)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x865.6.1) (:span 64 70)))\n (:nscopes ((:id . :x865.6.1) (:span 64 109)))\n (:identifiers (:sid . :s865.6) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008084@unknown@formal@none@1@S@Furthermore, 1 alpha,25-(OH)2D3 induced 24-hydroxylase mRNA expression and metabolic activity in both U937 cells and lectin-activated T cells, yet failed to induce 24-hydroxylase mRNA or its metabolic activity in B cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "alpha,25-(OH)2D3") (:form . "alpha,25-(OH)2D3")\n  (:end . 31) (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "24-hydroxylase") (:form . "24-hydroxylase")\n  (:end . 54) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lectin-activated") (:form . "lectin-activated")\n  (:end . 133) (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 153)\n  (:start . 147) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "24-hydroxylase") (:form . "24-hydroxylase")\n  (:end . 178) (:start . 164) (:id . 66))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 183) (:start . 179)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 200)\n  (:start . 191) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 209)\n  (:start . 201) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 214) (:start . 213)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x865.7.1) (:span 147 153)))\n (:nscopes ((:id . :x865.7.1) (:span 147 220)))\n (:identifiers (:sid . :s865.7) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008085@unknown@formal@none@1@S@These findings suggest that although human B lymphocytes can express VDR mRNA and protein, they exhibit a functional block for vitamin D-dependent gene regulation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "JJ") (:stem . "d-dependent") (:form . "D-dependent") (:end . 146)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 162)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x865.8.1) (:span 15 22)))\n (:hscopes ((:id . :x865.8.1) (:span 15 162)))\n (:identifiers (:sid . :s865.8) (:did . :|8175775|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008086@unknown@formal@none@1@S@Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos.@(((:tag . "NNPS") (:stem . "Effect") (:form . "Effects") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "alpha-lipoic") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dihydrolipoic") (:form . "dihydrolipoic")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s866.1) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008087@unknown@formal@none@1@S@The transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-tetradecanoyl-phorbol-13 acetate (TPA).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "12-o-tetradecanoyl-phorbol-13")\n  (:form . "12-O-tetradecanoyl-phorbol-13") (:end . 168) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s866.2) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008088@unknown@formal@none@1@S@The AP-1 complex consists of distinct protein heterodimers encoded by the proto-oncogene c-fos and c-jun mRNA whose gene expression can be induced by TPA, cyclic AMP and growth factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 88) (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 161)\n  (:start . 155) (:id . 67))\n ((:tag . "NN") (:stem . "amp") (:form . "AMP") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 184)\n  (:start . 177) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s866.3) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008090@unknown@formal@none@1@S@To investigate the role of reactive oxygen species we studied the effects of alpha-lipoic acid and dihydrolipoic acid (natural thiol antioxidants) on the expression of c-fos mRNA in human Jurkat T cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "alpha-lipoic") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dihydrolipoic") (:form . "dihydrolipoic")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 145)\n  (:start . 133) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 164)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 173)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 194)\n  (:start . 188) (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s866.5) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008091@unknown@formal@none@1@S@When cells were preincubated with dihydrolipoic acid (0.2 mM) the expression of c-fos mRNA was suppressed at 30 min after stimulation of TPA (0.5 microM) whereas in the case of preincubation of alpha-lipoic acid (0.2 microM), the expression was enhanced at 30 min.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dihydrolipoic") (:form . "dihydrolipoic")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . 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")") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 161)\n  (:start . 154) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 73))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 173) (:start . 169)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 75))\n ((:tag . "NN") (:stem . "preincubation") (:form . "preincubation")\n  (:end . 190) (:start . 177) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "alpha-lipoic") (:form . "alpha-lipoic") (:end . 206)\n  (:start . 194) (:id . 78))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 211) (:start . 207)\n  (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 213) (:start . 212)\n  (:id . 80))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 216) (:start . 213)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 223)\n  (:start . 217) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 85))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 240)\n  (:start . 230) (:id . 86))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 244) (:start . 241)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 253)\n  (:start . 245) (:id . 88))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 256) (:start . 254)\n  (:id . 89))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 259) (:start . 257)\n  (:id . 90))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 263) (:start . 260)\n  (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s866.6) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008092@unknown@formal@none@1@S@These studies support the idea that superoxide anion radical plays a role in the expression of c-fos mRNA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "superoxide") (:form . "superoxide") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "anion") (:form . "anion") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x866.7.1) (:span 26 30)))\n (:hscopes ((:id . :x866.7.1) (:span 26 105)))\n (:identifiers (:sid . :s866.7) (:did . :|8179594|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008093@unknown@formal@none@1@S@Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.@(((:tag . "JJ") (:stem . "alternative") (:form . "Alternative") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "generate") (:form . "generates") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s867.1) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008094@unknown@formal@none@1@S@The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70 I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "105-kda") (:form . "105-kDa") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p70") (:form . "p70") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 145)\n  (:start . 138) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 148) (:start . 147)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 154)\n  (:start . 149) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 156) (:start . 155)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 162)\n  (:start . 157) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 74))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 169)\n  (:start . 164) (:id . 75))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 172) (:start . 170)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 182)\n  (:start . 173) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 200)\n  (:start . 190) (:id . 80))\n ((:tag . "CD") (:stem . "607") (:form . "607") (:end . 204) (:start . 201)\n  (:id . 81))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 210)\n  (:start . 205) (:id . 82))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 216)\n  (:start . 211) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 84))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 224) (:start . 220)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s867.2) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008095@unknown@formal@none@1@S@Here we show that alternative RNA splicing generates I kappa B gamma isoforms with properties different from those of p70.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "splicing") (:form . "splicing") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBZ") (:stem . "generate") (:form . "generates") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p70") (:form . "p70") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s867.3) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008096@unknown@formal@none@1@S@One 63-kDa isoform, termed I kappa B gamma-1, which lacks 59 amino acids C-terminal to ankyrin repeat 7, has a novel 35-amino acid C terminus encoded by an alternative reading frame of the p105 gene.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "63-kda") (:form . "63-kDa") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 26) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gamma-1") (:form . "gamma-1") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "CD") (:stem . "59") (:form . "59") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 83)\n  (:start . 73) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 116)\n  (:start . 111) (:id . 65))\n ((:tag . "NN") (:stem . "35-amino") (:form . "35-amino") (:end . 125)\n  (:start . 117) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 130) (:start . 126)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 132) (:start . 131)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "terminus") (:form . "terminus") (:end . 141)\n  (:start . 133) (:id . 69))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 149)\n  (:start . 142) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 155) (:start . 153)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 167)\n  (:start . 156) (:id . 73))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 175)\n  (:start . 168) (:id . 74))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 181)\n  (:start . 176) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 193) (:start . 189)\n  (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 198) (:start . 194)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x867.4.1) (:span 52 57)))\n (:nscopes ((:id . :x867.4.1) (:span 52 103)))\n (:identifiers (:sid . :s867.4) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008097@unknown@formal@none@1@S@A 55-kDa isoform, I kappa B gamma-2, lacks the 190 C-terminal amino acids of p70I kappa B gamma.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "55-kda") (:form . "55-kDa") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma-2") (:form . "gamma-2") (:end . 35)\n  (:start . 28) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 42) (:start . 37)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "CD") (:stem . "190") (:form . "190") (:end . 50) (:start . 47)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 61)\n  (:start . 51) (:id . 54))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 67) (:start . 62)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p70i") (:form . "p70I") (:end . 81) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 95) (:start . 90)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x867.5.1) (:span 37 42)))\n (:nscopes ((:id . :x867.5.1) (:span 37 95)))\n (:identifiers (:sid . :s867.5) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008098@unknown@formal@none@1@S@In contrast to p70I kappa B gamma, which is a cytoplasmic protein, I kappa B gamma-1 is found in both the cytoplasm and nucleus, whereas I kappa B gamma-2 is predominantly nuclear.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p70i") (:form . "p70I") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 57)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 74) (:start . 69)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gamma-1") (:form . "gamma-1") (:end . 84)\n  (:start . 77) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 93) (:start . 88)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 115)\n  (:start . 106) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 127)\n  (:start . 120) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 68))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 136)\n  (:start . 129) (:id . 69))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 138) (:start . 137)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 144)\n  (:start . 139) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 146) (:start . 145)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gamma-2") (:form . "gamma-2") (:end . 154)\n  (:start . 147) (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 157) (:start . 155)\n  (:id . 74))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 171) (:start . 158) (:id . 75))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 179)\n  (:start . 172) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s867.6) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008100@unknown@formal@none@1@S@While p70I kappa B gamma inhibits p50-, p65-, and c-Rel-mediated transactivation and/or DNA binding, both I kappa B gamma-1 and I kappa B gamma-2 are specific for p50 and have different affinities for this subunit.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p70i") (:form . "p70I") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "p50-") (:form . "p50-") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p65-") (:form . "p65-") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "c-rel-mediated") (:form . "c-Rel-mediated")\n  (:end . 64) (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 80) (:start . 65) (:id . 54))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gamma-1") (:form . "gamma-1") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gamma-2") (:form . "gamma-2") (:end . 145)\n  (:start . 138) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 158)\n  (:start . 150) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 162) (:start . 159)\n  (:id . 71))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 73))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 175) (:start . 171)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 185)\n  (:start . 176) (:id . 75))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 196)\n  (:start . 186) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 200) (:start . 197)\n  (:id . 77))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 205) (:start . 201)\n  (:id . 78))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 213)\n  (:start . 206) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s867.8) (:did . :|8183915|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008101@unknown@formal@none@1@S@The absence in I kappa B gamma-1 and I kappa B gamma-2 of a protein kinase A site whose phosphorylation modulates p70I kappa B gamma inhibitory activity suggests that alternative RNA splicing may be used to generate I kappa B gamma isoforms that respond differently to intracellular signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gamma-1") (:form . "gamma-1") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "CC") (:stem . 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5008102@unknown@formal@none@1@S@Activation of nuclear factor kappa B in human lymphoblastoid cells by low-dose ionizing radiation.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 60) (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low-dose") (:form . "low-dose") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s868.1) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008103@unknown@formal@none@1@S@Nuclear factor kappa B (NF-kappa B) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 52)\n  (:start . 41) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 114) (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 125)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s868.2) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008104@unknown@formal@none@1@S@Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kappa B in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2-50") (:form . "2-50") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Gy") (:form . "Gy") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "kg-1") (:form . "KG-1") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "b-lymphocyte") (:form . "B-lymphocyte") (:end . 176)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 186)\n  (:start . 177) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 192)\n  (:start . 187) (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 205)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 215)\n  (:start . 206) (:id . 75))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 224)\n  (:start . 216) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 78))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 245)\n  (:start . 233) (:id . 79))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 249) (:start . 246)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 253) (:start . 250)\n  (:id . 81))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 257) (:start . 254)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 263)\n  (:start . 258) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x868.3.1) (:span 250 253 258 263)))\n (:hscopes ((:id . :x868.3.1) (:span 194 263)))\n (:identifiers (:sid . :s868.3) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008105@unknown@formal@none@1@S@The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kappa B in EBV-transformed 244B human lymphoblastoid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "CD") (:stem . "0.25-2.0") (:form . "0.25-2.0") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "Gy") (:form . "Gy") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 157) (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "244b") (:form . "244B") (:end . 162) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 183) (:start . 169) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s868.4) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008106@unknown@formal@none@1@S@These results are in a dose range where the viability of the cells remains very high.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s868.5) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008107@unknown@formal@none@1@S@After exposure to 137Cs gamma rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kappa B was seen at 8 h after a 0.5-Gy exposure.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "137c") (:form . "137Cs") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "ray") (:form . "rays") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1.17") (:form . "1.17") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Gy/min") (:form . "Gy/min") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 75)\n  (:start . 68) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 112) (:start . 108)\n  (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 115) (:start . 113)\n  (:id . 65))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 117) (:start . 116)\n  (:id . 66))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 119) (:start . 118)\n  (:id . 67))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 125)\n  (:start . 120) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "0.5-gy") (:form . "0.5-Gy") (:end . 134)\n  (:start . 128) (:id . 70))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 143)\n  (:start . 135) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s868.6) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008108@unknown@formal@none@1@S@Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures.@(((:tag . "JJ") (:stem . "time-course") (:form . "Time-course") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "time-dependent") (:form . "time-dependent")\n  (:end . 54) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 71) (:start . 66)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.5-") (:form . "0.5-") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1-") (:form . "1-") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "2-gy") (:form . "2-Gy") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s868.7) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008110@unknown@formal@none@1@S@The expression of the p50 and p65 NF-kappa B subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 99) (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "exposure") (:form . "exposures") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "CD") (:stem . "2.0") (:form . "2.0") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Gy") (:form . "Gy") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s868.9) (:did . :|8184011|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008111@unknown@formal@none@1@S@Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-alpha, IL-beta, and IL-6 by human peripheral blood mononuclear cells.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "co-ordinate") (:form . "co-ordinate") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 98)\n  (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-beta") (:form . "IL-beta") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s869.1) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008112@unknown@formal@none@1@S@Some antioxidants, including butylated hydroxyanisole (BHA), tetrahydropapaveroline (THP), nordihydroguiauretic acid, and 10,11-dihydroxyaporphine (DHA), were found to be potent inhibitors of the production of tumor necrosis factor (TNF)-alpha, IL-1 beta, and IL-6 by human peripheral blood mononuclear cells (PBMC) stimulated by lipopolysaccharide (LPS) (IC50s in the low micromolar range).@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "butylate") (:form . "butylated") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "hydroxyanisole") (:form . 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5008113@unknown@formal@none@1@S@Inhibition of cytokine production was gene selective and not due to general effects on protein synthesis.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x869.3.1) (:span 57 60)))\n (:nscopes ((:id . :x869.3.1) (:span 57 104)))\n (:identifiers (:sid . :s869.3) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008114@unknown@formal@none@1@S@Inhibition of cytokine production by PBMC was observed also when other inducers were used (staphylococci, silica, zymosan).@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "staphylococci") (:form . "staphylococci")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "silica") (:form . "silica") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "zymosan") (:form . "zymosan") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s869.4) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008115@unknown@formal@none@1@S@Much higher concentrations of other antioxidants--including ascorbic acid, trolox, alpha-tocopherol, butylated hydroxytoluene, and the 5-lipoxygenase inhibitor zileuton--did not affect the production of these cytokines.@(((:tag . "RB") (:stem . "much") (:form . "Much") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "antioxidants–including")\n  (:form . "antioxidants–including") (:end . 59) (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "ascorbic") (:form . "ascorbic") (:end . 68)\n  (:start . 60) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 73) (:start . 69)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "trolox") (:form . "trolox") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . "alpha-tocopherol")\n  (:end . 99) (:start . 83) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "butylate") (:form . "butylated") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "hydroxytoluene") (:form . "hydroxytoluene")\n  (:end . 125) (:start . 111) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "NN") (:stem . "5-lipoxygenase") (:form . "5-lipoxygenase")\n  (:end . 149) (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 159)\n  (:start . 150) (:id . 61))\n ((:tag . "VBD") (:stem . "zileuton–did") (:form . "zileuton–did")\n  (:end . 173) (:start . 160) (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 177) (:start . 174)\n  (:id . 63))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 184)\n  (:start . 178) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 65))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 199)\n  (:start . 189) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 208)\n  (:start . 203) (:id . 68))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 218)\n  (:start . 209) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x869.5.1) (:span 174 177)))\n (:nscopes ((:id . :x869.5.1) (:span 174 218)))\n (:identifiers (:sid . :s869.5) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008116@unknown@formal@none@1@S@The active compounds did not inhibit IL-1-induced production of IL-6 in fibroblasts, showing the cell selectivity of the effect.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "selectivity") (:form . "selectivity") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x869.6.1) (:span 25 28)))\n (:nscopes ((:id . :x869.6.1) (:span 25 83)))\n (:identifiers (:sid . :s869.6) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008117@unknown@formal@none@1@S@Antioxidant-mediated inhibition of cytokine production was correlated with low levels of the corresponding messenger RNAs.@(((:tag . "JJ") (:stem . "antioxidant-mediated")\n  (:form . "Antioxidant-mediated") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 31)\n  (:start . 21) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 43)\n  (:start . 35) (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 54)\n  (:start . 44) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 69)\n  (:start . 59) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 78) (:start . 75)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 85)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 106)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 116)\n  (:start . 107) (:id . 55))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s869.7) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008118@unknown@formal@none@1@S@Nuclear run-on experiments showed that THP inhibited transcription of the IL-1 beta gene.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 33) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "THP") (:form . "THP") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s869.8) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008120@unknown@formal@none@1@S@THP and DHA markedly decreased the levels of TNF-alpha and IL-1 beta in the circulation of mice following LPS injection.@(((:tag . "NNP") (:stem . "THP") (:form . "THP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DHA") (:form . "DHA") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "circulation") (:form . "circulation") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "injection") (:form . "injection") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s869.10) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008121@unknown@formal@none@1@S@Thus antioxidants vary widely in potency as inhibitors of the activation of transcription factors and of the transcription of genes for pro-inflammatory cytokines.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "vary") (:form . "vary") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 152) (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 162)\n  (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s869.11) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008122@unknown@formal@none@1@S@Coordinate inhibition of the transcription of genes for inflammatory cytokines could provide a strategy for therapy of diseases with inflammatory pathogenesis and for septic shock.@(((:tag . "JJ") (:stem . "coordinate") (:form . "Coordinate") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 145)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 158)\n  (:start . 146) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "septic") (:form . "septic") (:end . 173)\n  (:start . 167) (:id . 65))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 179)\n  (:start . 174) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s869.12) (:did . :|8186192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008123@unknown@formal@none@1@S@Central nervous system-derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR-independent transactivation by Tat.@(((:tag . "JJ") (:stem . "central") (:form . "Central") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "system-derived") (:form . "system-derived")\n  (:end . 30) (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 108) (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 114)\n  (:start . 109) (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 119) (:start . 115)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 121) (:start . 120)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 144)\n  (:start . 139) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "facilitate") (:form . "facilitates") (:end . 160)\n  (:start . 149) (:id . 62))\n ((:tag . "JJ") (:stem . "tar-independent") (:form . "TAR-independent")\n  (:end . 176) (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 192) (:start . 177) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 195) (:start . 193)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 199) (:start . 196)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s870.1) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008124@unknown@formal@none@1@S@The Tat protein of human immunodeficiency virus type 1 (HIV-1) is a potent activator of long terminal repeat-directed transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 41) (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 74)\n  (:start . 68) (:id . 56))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . "JJ") (:stem . "repeat-directed") (:form . "repeat-directed")\n  (:end . 117) (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s870.2) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008125@unknown@formal@none@1@S@While in most cell types, activation requires interaction of Tat with the unusual transcription element TAR, astrocytic glial cells support TAR-independent transactivation of HIV-1 transcription by Tat.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "tar") (:form . "TAR") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "astrocytic") (:form . "astrocytic") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "JJ") (:stem . "tar-independent") (:form . "TAR-independent")\n  (:end . 155) (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 171) (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 194) (:start . 181) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 197) (:start . 195)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s870.3) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008126@unknown@formal@none@1@S@This alternative pathway of Tat activation is mediated by the viral enhancer, a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B (NF-kappa B) present in many cell types, including T lymphocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "prototypical") (:form . "prototypical") (:end . 130)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 156) (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 184)\n  (:start . 179) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 186) (:start . 185)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 196)\n  (:start . 188) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 198) (:start . 197)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 207)\n  (:start . 200) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 215) (:start . 211)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 220) (:start . 216)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 226)\n  (:start . 221) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 227) (:start . 226)\n  (:id . 82))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 237)\n  (:start . 228) (:id . 83))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 239) (:start . 238)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 251)\n  (:start . 240) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s870.4) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008127@unknown@formal@none@1@S@Tat transactivation mediated by the kappa B domain is sufficient to allow replication of TAR-deleted mutant HIV-1 in astrocytes.@(((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tar-deleted") (:form . "TAR-deleted") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s870.5) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008128@unknown@formal@none@1@S@The present study demonstrates the existence of kappa B-specific binding factors present in human glial astrocytes that differ from prototypical NF-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "b-specific") (:form . "B-specific") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "prototypical") (:form . "prototypical") (:end . 144)\n  (:start . 132) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s870.6) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008130@unknown@formal@none@1@S@In vitro transcription studies demonstrate that astrocyte-derived kappa B-binding factors activate transcription of the HIV-1 long terminal repeat and that this activation is dependent on the kappa B domain.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "astrocyte-derived") (:form . "astrocyte-derived")\n  (:end . 65) (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 71) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 81)\n  (:start . 72) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 51))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 98)\n  (:start . 90) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 125)\n  (:start . 120) (:id . 56))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 130) (:start . 126)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 139)\n  (:start . 131) (:id . 58))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 146)\n  (:start . 140) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 160) (:start . 156)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 171)\n  (:start . 161) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 174) (:start . 172)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 184)\n  (:start . 175) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 187) (:start . 185)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 197)\n  (:start . 192) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 199) (:start . 198)\n  (:id . 69))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 206)\n  (:start . 200) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s870.8) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008131@unknown@formal@none@1@S@Moreover, TAR-independent transactivation of HIV-1 transcription is reproduced in vitro in an astrocyte factor-dependent manner which correlates with kappa B-binding activity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "tar-independent") (:form . "TAR-independent")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 41) (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reproduce") (:form . "reproduced") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "astrocyte") (:form . "astrocyte") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . "JJ") (:stem . "factor-dependent") (:form . "factor-dependent")\n  (:end . 120) (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 127)\n  (:start . 121) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 58))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 144)\n  (:start . 134) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 149) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 155)\n  (:start . 150) (:id . 61))\n ((:tag . "JJ") (:stem . "b-binding") (:form . "B-binding") (:end . 165)\n  (:start . 156) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 174)\n  (:start . 166) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s870.9) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008132@unknown@formal@none@1@S@The importance of the central nervous system-enriched kappa B transcription factor in the regulation of HIV-1 expression is discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "system-enriched") (:form . "system-enriched")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 133)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s870.10) (:did . :|8189531|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008133@unknown@formal@none@1@S@An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intricate") (:form . "intricate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "arrangement") (:form . "arrangement") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s871.1) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008134@unknown@formal@none@1@S@alpha 4 integrins mediate cell-cell and cell-extracellular matrix interactions that are critical for maturation and function of the immune system as well as differentiation of skeletal muscle.@(((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "cell-cell") (:form . "cell-cell") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-extracellular") (:form . "cell-extracellular")\n  (:end . 58) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 78)\n  (:start . 66) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 138)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 145)\n  (:start . 139) (:id . 61))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 172) (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "skeletal") (:form . "skeletal") (:end . 184)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 191)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s871.2) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008135@unknown@formal@none@1@S@Here we examine molecular mechanisms controlling the pattern of alpha 4 expression.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "examine") (:form . "examine") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s871.3) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008136@unknown@formal@none@1@S@The activity of constructs containing 5' deletion mutants of the alpha 4 gene promoter was compared in transfection assays into cell lines that express alpha 4 and cell lines that do not.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 115)\n  (:start . 103) (:id . 60))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 168) (:start . 164)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x871.4.1) (:span 183 186)))\n (:nscopes ((:id . :x871.4.1) (:span 183 186)))\n (:identifiers (:sid . :s871.4) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008137@unknown@formal@none@1@S@The sequence between position -42 and -76 base pairs (bp) was required for efficient transcription in cells that express alpha 4, but it showed no activity in HeLa cells, which do not express alpha 4.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "CD") (:stem . "-42") (:form . "-42") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-76") (:form . "-76") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 143)\n  (:start . 137) (:id . 68))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 155)\n  (:start . 147) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 163) (:start . 159)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 169)\n  (:start . 164) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 74))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 176)\n  (:start . 171) (:id . 75))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 179) (:start . 177)\n  (:id . 76))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 183) (:start . 180)\n  (:id . 77))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 191)\n  (:start . 184) (:id . 78))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 197)\n  (:start . 192) (:id . 79))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 199) (:start . 198)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x871.5.1) (:span 180 183))\n  ((:id . :x871.5.2) (:span 144 146)))\n (:nscopes ((:id . :x871.5.1) (:span 180 199))\n  ((:id . :x871.5.2) (:span 144 199)))\n (:identifiers (:sid . :s871.5) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008138@unknown@formal@none@1@S@Three binding sites for the Ets family of transcription factors are found in this region: two adjacent sites at positions -50 and -54 bp and a more 5' site at position -67 bp.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 13) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "CD") (:stem . "-50") (:form . "-50") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-54") (:form . "-54") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 155) (:start . 151)\n  (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 158) (:start . 156)\n  (:id . 73))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 167)\n  (:start . 159) (:id . 74))\n ((:tag . "CD") (:stem . "-67") (:form . "-67") (:end . 171) (:start . 168)\n  (:id . 75))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 174) (:start . 172)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s871.6) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008140@unknown@formal@none@1@S@When all three sites were present, a second complex "a" was detected, which contains an unknown member of the Ets family.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "\\"a") (:form . "\\"a") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 75) (:start . 70)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 102)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 120)\n  (:start . 114) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s871.8) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008141@unknown@formal@none@1@S@Formation of complex a was cell-type specific and correlated with a high level of transcription.@(((:tag . "NN") (:stem . "formation") (:form . "Formation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s871.9) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008142@unknown@formal@none@1@S@Deletion of the 5'-most Ets site had no effect on binding to GABP alpha/GABP beta, but it eliminated a.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "5'-most") (:form . "5'-most") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "alpha/GABP") (:form . "alpha/GABP") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "eliminate") (:form . "eliminated") (:end . 100)\n  (:start . 90) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x871.10.1) (:span 37 39)))\n (:nscopes ((:id . :x871.10.1) (:span 37 81)))\n (:identifiers (:sid . :s871.10) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008143@unknown@formal@none@1@S@Concomitant with this loss of a, a new Ets-1-containing complex "c" appeared.@(((:tag . "JJ") (:stem . "concomitant") (:form . "Concomitant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ets-1-containing") (:form . "Ets-1-containing")\n  (:end . 55) (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "JJ") (:stem . "\\"c") (:form . "\\"c") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s871.11) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008144@unknown@formal@none@1@S@Complex c substituted efficiently for complex a in transcriptional activation.@(((:tag . "NN") (:stem . "complex") (:form . "Complex") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "substitute") (:form . "substituted") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 66) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s871.12) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008145@unknown@formal@none@1@S@We conclude that although neither of the two 5'-most Ets sites alone binds nuclear protein, they appear to act as modulators which control the pattern of Ets proteins that bind the alpha 4 gene promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "5'-most") (:form . "5'-most") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "modulator") (:form . "modulators") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 150)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 186)\n  (:start . 181) (:id . 74))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 193) (:start . 189)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 202)\n  (:start . 194) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x871.13.1) (:span 97 103)))\n (:ncues ((:id . :x871.13.2) (:span 26 33)))\n (:hscopes ((:id . :x871.13.1) (:span 92 202)))\n (:nscopes ((:id . :x871.13.2) (:span 26 90)))\n (:identifiers (:sid . :s871.13) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008146@unknown@formal@none@1@S@This arrangement of Ets sites, coupled with the tissue- and developmental-specific expression of Ets members, likely play a key role in defining the pattern of alpha 4 integrin.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "arrangement") (:form . "arrangement") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tissue-") (:form . "tissue-") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "developmental-specific")\n  (:form . "developmental-specific") (:end . 82) (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "define") (:form . "defining") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 176)\n  (:start . 168) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x871.14.1) (:span 110 116)))\n (:hscopes ((:id . :x871.14.1) (:span 110 176)))\n (:identifiers (:sid . :s871.14) (:did . :|8195215|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008147@unknown@formal@none@1@S@Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 28)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 38)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 116)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 129)\n  (:start . 117) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 147)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s872.1) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008148@unknown@formal@none@1@S@Exposure of monocytic cells to bacterial lipopolysaccharide (LPS) activates the NF-kappa B/Rel family of proteins and leads to the rapid induction of inflammatory gene products, including tissue factor (TF).@(((:tag . "NN") (:stem . "exposure") (:form . "Exposure") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 59) (:start . 41) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 146)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 162)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 187)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 194)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 201)\n  (:start . 195) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 203) (:start . 202)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s872.2) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008150@unknown@formal@none@1@S@Here we report the characterization of a nuclear complex from human monocytic cells that bound to a kappa B-like site, 5'-CGGAGTTTCC-3', in the 5'-flanking region of the human TF gene.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 35) (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "5'-CGGAGTTTCC-3") (:form . "5'-CGGAGTTTCC-3")\n  (:end . 134) (:start . 119) (:id . 63))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 155)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 183) (:start . 179)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s872.4) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008151@unknown@formal@none@1@S@This nuclear complex was activated by LPS with kinetics that preceded induction of the TF gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "precede") (:form . "preceded") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s872.5) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008152@unknown@formal@none@1@S@In vitro binding studies demonstrated that the TF site bound translated c-Rel and p65 homodimers but not p50/p65 heterodimers or p50 homodimers.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 125)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x872.6.1) (:span 101 104)))\n (:nscopes ((:id . :x872.6.1) (:span 101 143)))\n (:identifiers (:sid . :s872.6) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008153@unknown@formal@none@1@S@Base-pair substitutions in the TF site indicated that the presence of a cytosine at position 1 precluded binding of NF-kappa B.@(((:tag . "JJ") (:stem . "base-pair") (:form . "Base-pair") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "substitution") (:form . "substitutions")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytosine") (:form . "cytosine") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "preclude") (:form . "precluded") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x872.7.1) (:span 39 53)))\n (:hscopes ((:id . :x872.7.1) (:span 39 126)))\n (:identifiers (:sid . :s872.7) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008154@unknown@formal@none@1@S@In fact, under low-ionic-strength conditions, the TF complex did not migrate with translated p50/p65 dimers but instead comigrated with c-Rel/p65 dimers.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low-ionic-strength") (:form . "low-ionic-strength")\n  (:end . 33) (:start . 15) (:id . 46))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "migrate") (:form . "migrate") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "VBD") (:stem . "comigrate") (:form . "comigrated") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 152)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x872.8.1) (:span 65 68)))\n (:nscopes ((:id . :x872.8.1) (:span 65 107)))\n (:identifiers (:sid . :s872.8) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008155@unknown@formal@none@1@S@Antibodies against the NF-kappa B and Rel proteins and UV cross-linking studies revealed the presence of c-Rel and p65 and the absence of p50 in the TF complex and further showed that c-Rel/p65 heterodimers selectively bound to the TF kappa B-like site.@(((:tag . "NNS") (:stem . "antibody") (:form . "Antibodies") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 171)\n  (:start . 164) (:id . 71))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 178)\n  (:start . 172) (:id . 72))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 206)\n  (:start . 194) (:id . 75))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 218)\n  (:start . 207) (:id . 76))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 224)\n  (:start . 219) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 227) (:start . 225)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 240)\n  (:start . 235) (:id . 81))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 247)\n  (:start . 241) (:id . 82))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 252) (:start . 248)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x872.9.1) (:span 127 134)))\n (:nscopes ((:id . :x872.9.1) (:span 127 159)))\n (:identifiers (:sid . :s872.9) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008156@unknown@formal@none@1@S@Functional studies indicated that the TF site conferred LPS inducibility on a heterologous promoter and was transactivated by c-Rel or p65.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 122) (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x872.10.1) (:span 19 33)))\n (:hscopes ((:id . :x872.10.1) (:span 19 138)))\n (:identifiers (:sid . :s872.10) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008157@unknown@formal@none@1@S@Taken together, our results demonstrated that binding of c-Rel/p65 heterodimers to a novel kappa B-like site mediated LPS induction of TF gene expression in monocytic cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 79)\n  (:start . 67) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 166)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s872.11) (:did . :|8196620|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008158@unknown@formal@none@1@S@Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "upregulate") (:form . "upregulates") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 65) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s873.1) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008160@unknown@formal@none@1@S@To investigate the effects of human immunodeficiency virus type 1 (HIV-1) Tat on interleukin-2 (IL-2) expression, we used IL-2 promoter-chloramphenicol acetyltransferase constructs and IL-2-secreting Jurkat T cells as a model system.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 52) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 94) (:start . 81) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "promoter-chloramphenicol")\n  (:form . "promoter-chloramphenicol") (:end . 151) (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 169) (:start . 152) (:id . 67))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "il-2-secreting") (:form . "IL-2-secreting")\n  (:end . 199) (:start . 185) (:id . 70))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 206)\n  (:start . 200) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 208) (:start . 207)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 219) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 232)\n  (:start . 226) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s873.3) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008161@unknown@formal@none@1@S@Transient expression of HIV-1 Tat induced a five- to eightfold increase in IL-2 promoter activity in Jurkat T cells stimulated with phytohemagglutinin and phorbol myristate acetate.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CD") (:stem . "five-") (:form . "five-") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "eightfold") (:form . "eightfold") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 150) (:start . 132) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 162)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 180)\n  (:start . 173) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s873.4) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008162@unknown@formal@none@1@S@IL-2 secretion was increased more than twofold in both Jurkat T cells and primary T cells stimulated by extracellular HIV-1 Tat protein.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "twofold") (:form . "twofold") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s873.5) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008163@unknown@formal@none@1@S@Analysis of mRNA suggested that Tat exerts its effect on IL-2 primarily at the transcriptional level.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 94) (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x873.6.1) (:span 17 26)))\n (:hscopes ((:id . :x873.6.1) (:span 17 100)))\n (:identifiers (:sid . :s873.6) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008164@unknown@formal@none@1@S@The NF-kappa B site at positions -206 to -195 of the IL-2 promoter was required but not sufficient for the Tat effect.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "CD") (:stem . "-206") (:form . "-206") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-195") (:form . "-195") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 117)\n  (:start . 111) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x873.7.1) (:span 84 87)))\n (:nscopes ((:id . :x873.7.1) (:span 84 117)))\n (:identifiers (:sid . :s873.7) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008165@unknown@formal@none@1@S@The Tat-mediated increase in IL-2 promoter activity could selectively be blocked by antisense tat or-unlike the analogous effect of human T-cell lymphotropic virus type 1 Tax-by cyclosporin A.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tat-mediated") (:form . "Tat-mediated") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 69)\n  (:start . 58) (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "tat") (:form . "tat") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "or-unlike") (:form . "or-unlike") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 157)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 163)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 170) (:start . 169)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Tax-by") (:form . "Tax-by") (:end . 177)\n  (:start . 171) (:id . 67))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 189)\n  (:start . 178) (:id . 68))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 191) (:start . 190)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s873.8) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008166@unknown@formal@none@1@S@The observed increase in IL-2 levels might facilitate virus spread from or to T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "spread") (:form . "spread") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x873.9.1) (:span 37 42)))\n (:hscopes ((:id . :x873.9.1) (:span 37 85)))\n (:identifiers (:sid . :s873.9) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008167@unknown@formal@none@1@S@Furthermore, it might contribute to the hypergammaglobulinemia or, together with other cytokines found to be dysregulated, the T-helper cell dysfunctions observed in AIDS patients.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypergammaglobulinemia")\n  (:form . "hypergammaglobulinemia") (:end . 62) (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "dysregulate") (:form . "dysregulated") (:end . 121)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "T-helper") (:form . "T-helper") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "dysfunction") (:form . "dysfunctions") (:end . 153)\n  (:start . 141) (:id . 64))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 179)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x873.10.1) (:span 16 21)))\n (:hscopes ((:id . :x873.10.1) (:span 16 179)))\n (:identifiers (:sid . :s873.10) (:did . :|8207793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008168@unknown@formal@none@1@S@Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C-zeta") (:form . "C-zeta") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 78) (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "virus-infected") (:form . "virus-infected")\n  (:end . 93) (:start . 79) (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 103)\n  (:start . 94) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s874.1) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008170@unknown@formal@none@1@S@NF-kappa B is a transcription factor involved in the regulation of the HIV long terminal repeat and is selectively activated following HIV infection of human macrophages.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 114)\n  (:start . 103) (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 169)\n  (:start . 158) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s874.3) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008171@unknown@formal@none@1@S@Although little information as to what signal transduction pathways mediate NF-kappa B activation in monocytes-macrophages is available, our previous work indicated that classical protein kinase C (PKC) isoenzymes were not involved in the HIV-mediated NF-kappa B activation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "WP") (:stem . "what") (:form . "what") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocytes-macrophage")\n  (:form . "monocytes-macrophages") (:end . 122) (:start . 101) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 149)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 154) (:start . 150)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 164)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 179)\n  (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 187)\n  (:start . 180) (:id . 66))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 194)\n  (:start . 188) (:id . 67))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 196) (:start . 195)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "isoenzyme") (:form . "isoenzymes") (:end . 213)\n  (:start . 203) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 218) (:start . 214)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 222) (:start . 219)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 231)\n  (:start . 223) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 234) (:start . 232)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "hiv-mediated") (:form . "HIV-mediated") (:end . 251)\n  (:start . 239) (:id . 78))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 260)\n  (:start . 252) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 262) (:start . 261)\n  (:id . 80))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 273)\n  (:start . 263) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x874.4.2) (:span 155 169)))\n (:ncues ((:id . :x874.4.1) (:span 219 222)))\n (:hscopes ((:id . :x874.4.2) (:span 155 273)))\n (:nscopes ((:id . :x874.4.1) (:span 219 273)))\n (:identifiers (:sid . :s874.4) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008172@unknown@formal@none@1@S@In this study, we have focused on atypical PKC isoenzymes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 42)\n  (:start . 34) (:id . 50))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "isoenzyme") (:form . "isoenzymes") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s874.5) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008173@unknown@formal@none@1@S@PKC-zeta belongs to this family and is known to be an important step in NF-kappa B activation in other cell systems.@(((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s874.6) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008174@unknown@formal@none@1@S@Immunoblotting experiments with U937 cells demonstrate that PKC-zeta is present in these cells, and its expression can be downmodulated by antisense oligonucleotides (AO).@(((:tag . "NN") (:stem . "immunoblotting") (:form . "Immunoblotting")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 26)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "downmodulate") (:form . "downmodulated")\n  (:end . 135) (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 165) (:start . 149) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "AO") (:form . "AO") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s874.7) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008175@unknown@formal@none@1@S@The HIV-mediated NF-kappa B activation is selectively reduced by AO to PKC-zeta.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hiv-mediated") (:form . "HIV-mediated") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AO") (:form . "AO") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s874.8) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008176@unknown@formal@none@1@S@In addition, cotransfection of a negative dominant molecule of PKC-zeta (PKC-zeta mut) with NF-kappa B-dependent reporter genes selectively inhibits the HIV- but not phorbol myristate acetate- or lipopolysaccharide-mediated activation of NF-kappa B.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "mut") (:form . "mut") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 112)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hiv-") (:form . "HIV-") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 183)\n  (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "acetate-") (:form . "acetate-") (:end . 192)\n  (:start . 184) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-mediated")\n  (:form . "lipopolysaccharide-mediated") (:end . 223) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 234)\n  (:start . 224) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 246)\n  (:start . 238) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 248) (:start . 247)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x874.9.1) (:span 162 165)))\n (:nscopes ((:id . :x874.9.1) (:span 162 248)))\n (:identifiers (:sid . :s874.9) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008177@unknown@formal@none@1@S@That PKC-zeta is specific in regulating NF-kappa B is concluded from the inability of PKC-zeta(mut) to interfere with the basal or phorbol myristate acetate-inducible CREB- or AP1-dependent transcriptional activity.@(((:tag . "DT") (:stem . "that") (:form . "That") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC-zeta(mut)") (:form . "PKC-zeta(mut)")\n  (:end . 99) (:start . 86) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VB") (:stem . "interfere") (:form . "interfere") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "JJ") (:stem . "acetate-inducible") (:form . "acetate-inducible")\n  (:end . 166) (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "creb-") (:form . "CREB-") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "ap1-dependent") (:form . "AP1-dependent")\n  (:end . 189) (:start . 176) (:id . 68))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 205) (:start . 190) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 214)\n  (:start . 206) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s874.10) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008178@unknown@formal@none@1@S@Lastly, we demonstrate a selective inhibition of p24 production by HIV-infected human macrophages when treated with AO to PKC-zeta.@(((:tag . "RB") (:stem . "lastly") (:form . "Lastly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 79)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "AO") (:form . "AO") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PKC-zeta") (:form . "PKC-zeta") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s874.11) (:did . :|8523529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008180@unknown@formal@none@1@S@Initiation binding repressor, a factor that binds to the transcription initiation site of the histone h5 gene, is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735]@(((:tag . "NN") (:stem . "initiation") (:form . "Initiation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "h5") (:form . "h5") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "glycosylate") (:form . "glycosylated") (:end . 128)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 147)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 162)\n  (:start . 156) (:id . 70))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 173)\n  (:start . 163) (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 175) (:start . 174)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "correct") (:form . "corrected") (:end . 184)\n  (:start . 175) (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 187) (:start . 186)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 196)\n  (:start . 187) (:id . 76))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 204)\n  (:start . 197) (:id . 77))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 212)\n  (:start . 205) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Mol") (:form . "Mol") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Cell") (:form . "Cell") (:end . 224) (:start . 220)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Biol") (:form . "Biol") (:end . 229) (:start . 225)\n  (:id . 82))\n ((:tag . "CD") (:stem . "1996") (:form . "1996") (:end . 234) (:start . 230)\n  (:id . 83))\n ((:tag . "NN") (:stem . "Feb;16(2):735") (:form . "Feb;16(2):735")\n  (:end . 248) (:start . 235) (:id . 84))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 249) (:start . 248)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s875.1) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008181@unknown@formal@none@1@S@Initiation binding repressor [corrected] (IBR) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the histone h5 gene, repressing its transcription.@(((:tag . "NN") (:stem . "initiation") (:form . "Initiation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "correct") (:form . "corrected") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IBR") (:form . "IBR") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 71)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "CD") (:stem . "73") (:form . "73") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 129)\n  (:start . 124) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 146)\n  (:start . 137) (:id . 70))\n ((:tag . "VBG") (:stem . "span") (:form . "spanning") (:end . 155)\n  (:start . 147) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 173) (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 184)\n  (:start . 174) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 77))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 204)\n  (:start . 197) (:id . 78))\n ((:tag . "NN") (:stem . "h5") (:form . "h5") (:end . 207) (:start . 205)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 212) (:start . 208)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 81))\n ((:tag . "VBG") (:stem . "repress") (:form . "repressing") (:end . 224)\n  (:start . 214) (:id . 82))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 228) (:start . 225)\n  (:id . 83))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 242) (:start . 229) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s875.2) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008182@unknown@formal@none@1@S@A variety of other cells, including transformed erythroid precursors, do not have IBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same IBR sites.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IBR") (:form . "IBR") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IBF") (:form . "IBF") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "CD") (:stem . "68") (:form . "68") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 127) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 131) (:start . 128)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 148)\n  (:start . 138) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 157) (:start . 153)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ibr") (:form . "IBR") (:end . 161) (:start . 158)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 167)\n  (:start . 162) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x875.3.1) (:span 73 76)))\n (:nscopes ((:id . :x875.3.1) (:span 73 85)))\n (:identifiers (:sid . :s875.3) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008183@unknown@formal@none@1@S@We have cloned the IBR cDNA and studied the relationship of IBR and IBF.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IBR") (:form . "IBR") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 56)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IBR") (:form . "IBR") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IBF") (:form . "IBF") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s875.4) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008184@unknown@formal@none@1@S@IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product (EWG).@(((:tag . "NNP") (:stem . "IBR") (:form . "IBR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "503-amino-acid-long")\n  (:form . "503-amino-acid-long") (:end . 28) (:start . 9) (:id . 45))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "CD") (:stem . "99.0") (:form . "99.0") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nrf-1/alpha-pal") (:form . "NRF-1/alpha-Pal")\n  (:end . 115) (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "invertebrate") (:form . "invertebrate") (:end . 161)\n  (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 175) (:start . 162) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 183)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "p3a2") (:form . "P3A2") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "erect") (:form . "erected") (:end . 200)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 205) (:start . 201)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 210) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 218)\n  (:start . 211) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 220) (:start . 219)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "EWG") (:form . "EWG") (:end . 223) (:start . 220)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s875.5) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008185@unknown@formal@none@1@S@We present evidence that IBR and IBF are most likely identical proteins, differing in their degree of glycosylation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IBR") (:form . "IBR") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IBF") (:form . "IBF") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "differ") (:form . "differing") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 91)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "glycosylation") (:form . "glycosylation")\n  (:end . 115) (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x875.6.1) (:span 46 52)))\n (:hscopes ((:id . :x875.6.1) (:span 25 115)))\n (:identifiers (:sid . :s875.6) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008186@unknown@formal@none@1@S@We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable homodimers and that the dimer is the relevant DNA-binding species.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IBR/F") (:form . "IBR/F") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s875.7) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008187@unknown@formal@none@1@S@The evolutionarily conserved N-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IBR/F") (:form . "IBR/F") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "harbor") (:form . "harbors") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna-binding/dimerization")\n  (:form . "DNA-binding/dimerization") (:end . 90) (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 97)\n  (:start . 91) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "outer") (:form . "outer") (:end . 104) (:start . 99)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "limit") (:form . "limits") (:end . 111)\n  (:start . 105) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "CD") (:stem . "127") (:form . "127") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "CD") (:stem . "283") (:form . "283") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 140)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "casein") (:form . "casein") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "CD") (:stem . "67") (:form . "67") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 191)\n  (:start . 182) (:id . 77))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 199)\n  (:start . 192) (:id . 78))\n ((:tag . "NN") (:stem . "localization") (:form . 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5008188@unknown@formal@none@1@S@Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity IBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "alternate") (:form . "alternating") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "rcgcrygcgy") (:form . "RCGCRYGCGY") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "VBZ") (:stem . "constitute") (:form . "constitutes") (:end . 85)\n  (:start . 74) (:id . 51))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 99) (:start . 86) (:id . 52))\n ((:tag . "NN") (:stem . "ibr/f") (:form . "IBR/F") (:end . 105)\n  (:start . 100) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 119)\n  (:start . 114) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "direct-repeat") (:form . "direct-repeat")\n  (:end . 146) (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "palindrome") (:form . "palindrome") (:end . 157)\n  (:start . 147) (:id . 60))\n ((:tag . "NNP") (:stem . "TGCGCATGCGCA") (:form . "TGCGCATGCGCA")\n  (:end . 170) (:start . 158) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 173) (:start . 171)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 185)\n  (:start . 178) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 190) (:start . 186)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s875.9) (:did . :|8524232|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008190@unknown@formal@none@1@S@Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nf-at-dependent") (:form . "NF-AT-dependent")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 88)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 129)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s876.1) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008191@unknown@formal@none@1@S@Activation of individual CD4+ T cells results in differential lymphokine expression: interleukin 2 (IL-2) is preferentially produced by T helper type 1 (TH1) cells, which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells, which are essential for humoral immunity.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "result") (:form . 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5008192@unknown@formal@none@1@S@The Ca(2+)-dependent factor NF-ATp plays a key role in the inducible transcription of both these lymphokine genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s876.3) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008193@unknown@formal@none@1@S@However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C-dependent signals, we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "Ca(2+)-") (:form . "Ca(2+)-") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "c-dependent") (:form . "C-dependent") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 159) (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 167)\n  (:start . 160) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 188) (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 196)\n  (:start . 189) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 210)\n  (:start . 200) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 221)\n  (:start . 214) (:id . 73))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 228)\n  (:start . 222) (:id . 74))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 230) (:start . 229)\n  (:id . 75))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 242)\n  (:start . 231) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 245) (:start . 243)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 252)\n  (:start . 246) (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 254) (:start . 253)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 260)\n  (:start . 255) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s876.4) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008194@unknown@formal@none@1@S@This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence, an element located 69 bp upstream of the IL4 transcription initiation site.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "mutually") (:form . "mutually") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . "CD") (:stem . "69") (:form . "69") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 155) (:start . 142) (:id . 69))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 166)\n  (:start . 156) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s876.5) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008195@unknown@formal@none@1@S@Human IL4 promoter-mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B-activating cytokine tumor necrosis factor alpha and suppressed in RelA-overexpressing cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IL4") (:form . "IL4") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "promoter-mediated") (:form . "promoter-mediated")\n  (:end . 27) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 58) (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 68)\n  (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 85)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "JJ") (:stem . "b-activating") (:form . "B-activating") (:end . 116)\n  (:start . 104) (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 125)\n  (:start . 117) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 131)\n  (:start . 126) (:id . 57))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 140)\n  (:start . 132) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 153)\n  (:start . 148) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 168)\n  (:start . 158) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "rela-overexpressing")\n  (:form . "RelA-overexpressing") (:end . 191) (:start . 172) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s876.6) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008196@unknown@formal@none@1@S@In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence, which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 64) (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 147)\n  (:start . 139) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "higher-affinity") (:form . "higher-affinity")\n  (:end . 175) (:start . 160) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 180) (:start . 176)\n  (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 191)\n  (:start . 185) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "lower-affinity") (:form . "lower-affinity")\n  (:end . 212) (:start . 198) (:id . 77))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 217) (:start . 213)\n  (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 221) (:start . 218)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 226) (:start . 222)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x876.7.1) (:span 70 73)))\n (:nscopes ((:id . :x876.7.1) (:span 70 226)))\n (:identifiers (:sid . :s876.7) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008197@unknown@formal@none@1@S@Thus, competition between two general transcriptional activators, RelA and NF-ATp, mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il4") (:form . "IL4") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 198)\n  (:start . 186) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 203) (:start . 199)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 214)\n  (:start . 204) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "th") (:form . "TH") (:end . 220) (:start . 218)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 226)\n  (:start . 221) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x876.8.1) (:span 168 171)))\n (:hscopes ((:id . :x876.8.1) (:span 168 226)))\n (:identifiers (:sid . :s876.8) (:did . :|8524816|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008198@unknown@formal@none@1@S@Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 27) (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 96)\n  (:start . 85) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s877.1) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008200@unknown@formal@none@1@S@One such cofactor, BOB.1/OBF.1, was recently isolated from human B cells.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s877.3) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008201@unknown@formal@none@1@S@Here, we describe the isolation and detailed characterization of the murine homolog.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 61) (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s877.4) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008202@unknown@formal@none@1@S@Full-length cDNAs and genomic clones were isolated, and the gene structure was determined.@(((:tag . "JJ") (:stem . "full-length") (:form . "Full-length") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s877.5) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008203@unknown@formal@none@1@S@Comparison of the deduced amino acids shows 88% sequence identity between mouse and human BOB.1/OBF.1.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "deduce") (:form . "deduced") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "CD") (:stem . "88") (:form . "88") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s877.6) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008204@unknown@formal@none@1@S@The NH2-terminal 126 amino acids of BOB.1/OBF.1 are both essential and sufficient for interaction with the POU domains of either Oct1 or Oct2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "126") (:form . "126") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "oct1") (:form . "Oct1") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s877.7) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008205@unknown@formal@none@1@S@This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct-DNA interaction reveals that binding of BOB.1/OBF.1 to Oct1 or Oct2 does not alter the interaction with DNA.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 32)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 66)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "resolution") (:form . "resolution") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 131)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "oct-dna") (:form . "Oct-DNA") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 158)\n  (:start . 147) (:id . 64))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 166)\n  (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 179)\n  (:start . 172) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 194)\n  (:start . 183) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Oct1") (:form . "Oct1") (:end . 202) (:start . 198)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 205) (:start . 203)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Oct2") (:form . "Oct2") (:end . 210) (:start . 206)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 215) (:start . 211)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 77))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 241)\n  (:start . 230) (:id . 78))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 246) (:start . 242)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 250) (:start . 247)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x877.8.1) (:span 216 219))\n  ((:id . :x877.8.2) (:span 38 41)))\n (:nscopes ((:id . :x877.8.1) (:span 216 250))\n  ((:id . :x877.8.2) (:span 38 97)))\n (:identifiers (:sid . :s877.8) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008206@unknown@formal@none@1@S@BOB.1/OBF.1 can efficiently activate octamer-dependent promoters in fibroblasts; however, it fails to stimulate octamer-dependent enhancer activity.@(((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "octamer-dependent") (:form . "octamer-dependent")\n  (:end . 54) (:start . 37) (:id . 46))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 64)\n  (:start . 55) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 79)\n  (:start . 68) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 80) (:start . 79)\n  (:id . 50))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 88)\n  (:start . 81) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 98) (:start . 93)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "octamer-dependent") (:form . "octamer-dependent")\n  (:end . 129) (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 138)\n  (:start . 130) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 147)\n  (:start . 139) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x877.9.1) (:span 93 98)))\n (:nscopes ((:id . :x877.9.1) (:span 93 147)))\n (:identifiers (:sid . :s877.9) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008207@unknown@formal@none@1@S@Fusion of subdomains of BOB.1/OBF.1 with the GAL4 DNA binding domain reveals that both NH2- and COOH-terminal domains of BOB.1/OBF.1 contribute to full transactivation function, the COOH-terminal domain is more efficient in this transactivation assay.@(((:tag . "NN") (:stem . "fusion") (:form . "Fusion") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "subdomain") (:form . "subdomains") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GAL4") (:form . "GAL4") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NH2-") (:form . "NH2-") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cooh-terminal") (:form . "COOH-terminal")\n  (:end . 109) (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 167) (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 176)\n  (:start . 168) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cooh-terminal") (:form . "COOH-terminal")\n  (:end . 195) (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 202)\n  (:start . 196) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 210) (:start . 206)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 220)\n  (:start . 211) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 228) (:start . 224)\n  (:id . 75))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 244) (:start . 229) (:id . 76))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 250)\n  (:start . 245) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s877.10) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008208@unknown@formal@none@1@S@Consistent with the failure of full-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non B cells, the GAL4 fusions likewise only stimulate from a promoter-proximal position.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "octamer-dependent") (:form . "octamer-dependent")\n  (:end . 85) (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 94)\n  (:start . 86) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 103)\n  (:start . 95) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "non") (:form . "non") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "fusion") (:form . "fusions") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . "RB") (:stem . "likewise") (:form . "likewise") (:end . 145)\n  (:start . 137) (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "promoter-proximal") (:form . "promoter-proximal")\n  (:end . 185) (:start . 168) (:id . 67))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 194)\n  (:start . 186) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x877.11.1) (:span 20 27)))\n (:nscopes ((:id . :x877.11.1) (:span 20 118)))\n (:identifiers (:sid . :s877.11) (:did . :|8530384|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008210@unknown@formal@none@1@S@Atopy, which predisposes individuals to develop asthma, severe systemic anaphylaxis, and atopic dermatitis, is usually associated with dramatically elevated total serum IgE levels and is thought to be controlled by a major susceptibility gene and multiple minor susceptibility genes.@(((:tag . "NNP") (:stem . "Atopy") (:form . "Atopy") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "predispose") (:form . "predisposes") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VB") (:stem . "develop") (:form . "develop") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "anaphylaxis") (:form . "anaphylaxis") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "dermatitis") (:form . "dermatitis") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 147)\n  (:start . 135) (:id . 63))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 162)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 179)\n  (:start . 173) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 211)\n  (:start . 201) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 214) (:start . 212)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 222)\n  (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 237) (:start . 223) (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 242) (:start . 238)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 246) (:start . 243)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 255)\n  (:start . 247) (:id . 81))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 261)\n  (:start . 256) (:id . 82))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 276) (:start . 262) (:id . 83))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 282)\n  (:start . 277) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x878.2.1) (:span 187 194)))\n (:hscopes ((:id . :x878.2.1) (:span 184 282)))\n (:identifiers (:sid . :s878.2) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008211@unknown@formal@none@1@S@A recent sib-pair analysis revealed a tight linkage between markers on 5q31.1 and a major susceptibility gene controlling total serum IgE levels.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sib-pair") (:form . "sib-pair") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "linkage") (:form . "linkage") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "5q31.1") (:form . "5q31.1") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 104) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s878.3) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008212@unknown@formal@none@1@S@Due to its location within this cluster and its biologic role in Ig class switching and Th2 cell differentiation, the IL-4 gene has emerged as one major candidate for the atopy gene.@(((:tag . "JJ") (:stem . "due") (:form . "Due") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biologic") (:form . "biologic") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 112) (:start . 97) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 162)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "atopy") (:form . "atopy") (:end . 176)\n  (:start . 171) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 181) (:start . 177)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s878.4) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008213@unknown@formal@none@1@S@In one model, polymorphisms within IL-4 regulatory elements might result in overexpression of the gene, amplifying Th2 cell differentiation and class switching to IgE.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "polymorphism") (:form . "polymorphisms")\n  (:end . 27) (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 90) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "amplify") (:form . "amplifying") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 139) (:start . 124) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x878.5.1) (:span 60 65)))\n (:hscopes ((:id . :x878.5.1) (:span 60 166)))\n (:identifiers (:sid . :s878.5) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008214@unknown@formal@none@1@S@In support of this model, we report that the human IL-4 promoter exists in multiple allelic forms that exhibit distinct transcriptional activities in IL-4-positive T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "JJ") (:stem . "allelic") (:form . "allelic") (:end . 91)\n  (:start . 84) (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 135) (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "il-4-positive") (:form . "IL-4-positive")\n  (:end . 163) (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s878.6) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008215@unknown@formal@none@1@S@A particular allele has an unusually high transcriptional activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "unusually") (:form . "unusually") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s878.7) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008216@unknown@formal@none@1@S@A nucleotide substitution within a recently described OAP40 element located just upstream of an NF-AT site (P sequence) appears to be largely responsible for the increased promotor strength of this particular allelic form of the IL-4 promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "oap40") (:form . "OAP40") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 101)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 153)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 171)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "promotor") (:form . "promotor") (:end . 180)\n  (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "strength") (:form . "strength") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 197) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 208)\n  (:start . 198) (:id . 74))\n ((:tag . "JJ") (:stem . "allelic") (:form . "allelic") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 221) (:start . 217)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 233) (:start . 229)\n  (:id . 79))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 242)\n  (:start . 234) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x878.8.1) (:span 120 127)))\n (:hscopes ((:id . :x878.8.1) (:span 0 242)))\n (:identifiers (:sid . :s878.8) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008217@unknown@formal@none@1@S@In EMSAs, this substitution results in a markedly enhanced affinity for sequence-specific complexes exhibiting an AP-1 specificity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 27)\n  (:start . 15) (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 89) (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "VBG") (:stem . "exhibit") (:form . "exhibiting") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s878.9) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008218@unknown@formal@none@1@S@The identification of allelic nucleotides, which results in overexpression of the IL-4 gene, provides specific targets for a comprehensive screening of atopic and nonatopic individuals and may provide a clue for genetic predisposition for atopy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "allelic") (:form . "allelic") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 74) (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "comprehensive") (:form . "comprehensive")\n  (:end . 138) (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "screening") (:form . "screening") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nonatopic") (:form . "nonatopic") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 184)\n  (:start . 173) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 72))\n ((:tag . "NN") (:stem . "clue") (:form . "clue") (:end . 207) (:start . 203)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 219)\n  (:start . 212) (:id . 75))\n ((:tag . "NN") (:stem . "predisposition") (:form . "predisposition")\n  (:end . 234) (:start . 220) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 238) (:start . 235)\n  (:id . 77))\n ((:tag . "NN") (:stem . "atopy") (:form . "atopy") (:end . 244)\n  (:start . 239) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x878.10.1) (:span 189 192)))\n (:hscopes ((:id . :x878.10.1) (:span 189 244)))\n (:identifiers (:sid . :s878.10) (:did . :|8543789|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008220@unknown@formal@none@1@S@IL-10 is elevated in HIV-1-infected individuals and has been implicated in disease progression.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 35) (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s879.2) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008221@unknown@formal@none@1@S@In this study, we investigated the effects of IL-10 on the activation of HIV-1 from infected monocytes and macrophages.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 118)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s879.3) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008222@unknown@formal@none@1@S@Although IL-10 alone did not induce HIV-1 replication, in the presence of TNF-alpha, IL-10 markedly enhanced virion production from a chronically infected promonocytic cell line (U1) and in acutely infected monocyte-derived macrophages.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "virion") (:form . "virion") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 145)\n  (:start . 134) (:id . 64))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 167)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "U1") (:form . "U1") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "RB") (:stem . "acutely") (:form . "acutely") (:end . 197)\n  (:start . 190) (:id . 74))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 206)\n  (:start . 198) (:id . 75))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 223) (:start . 207) (:id . 76))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 235)\n  (:start . 224) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x879.4.1) (:span 25 28)))\n (:nscopes ((:id . :x879.4.1) (:span 25 53)))\n (:identifiers (:sid . :s879.4) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008223@unknown@formal@none@1@S@Neutralizing mAbs to IL-10 and TNF-alpha indicated that both cytokines were essential for the induction and were required to generate a synergistic increase in virus expression.@(((:tag . "VBG") (:stem . "neutralize") (:form . "Neutralizing") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 176)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x879.5.1) (:span 41 55)))\n (:hscopes ((:id . :x879.5.1) (:span 41 176)))\n (:identifiers (:sid . :s879.5) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008224@unknown@formal@none@1@S@The effects of the two cytokines were distinguishable functionally since pretreatment with TNF-alpha attenuated the cytokine cooperativity, while pretreatment with IL-10 potentiated their cooperativity, suggesting that IL-10 and TNF-alpha play different roles in the activation of virus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinguishable") (:form . "distinguishable")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 85)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "cooperativity") (:form . "cooperativity")\n  (:end . 138) (:start . 125) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 59))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 145)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 158)\n  (:start . 146) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 163) (:start . 159)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 169)\n  (:start . 164) (:id . 63))\n ((:tag . "VBD") (:stem . "potentiate") (:form . "potentiated") (:end . 181)\n  (:start . 170) (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 187)\n  (:start . 182) (:id . 65))\n ((:tag . "NN") (:stem . "cooperativity") (:form . "cooperativity")\n  (:end . 201) (:start . 188) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 213)\n  (:start . 203) (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 218) (:start . 214)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 224)\n  (:start . 219) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 238)\n  (:start . 229) (:id . 72))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 243) (:start . 239)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 253)\n  (:start . 244) (:id . 74))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 259)\n  (:start . 254) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 262) (:start . 260)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 266) (:start . 263)\n  (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 277)\n  (:start . 267) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 280) (:start . 278)\n  (:id . 79))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 286)\n  (:start . 281) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 287) (:start . 286)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x879.6.1) (:span 203 213)))\n (:hscopes ((:id . :x879.6.1) (:span 203 286)))\n (:identifiers (:sid . :s879.6) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008225@unknown@formal@none@1@S@Northern blot analysis as well as Ab blocking and cytokine secretion studies indicated that the induction of either endogenous TNF-alpha or IL-10 was not involved in the cooperativity, nor was an up-regulation of TNF-alpha receptors.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "blocking") (:form . "blocking") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cooperativity") (:form . "cooperativity")\n  (:end . 183) (:start . 170) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 195) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 209) (:start . 196) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 222)\n  (:start . 213) (:id . 76))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 232)\n  (:start . 223) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x879.7.3) (:span 77 91)))\n (:ncues ((:id . :x879.7.1) (:span 150 153 185 188)))\n (:hscopes ((:id . :x879.7.3) (:span 77 232)))\n (:nscopes ((:id . :x879.7.1) (:span 92 232)))\n (:identifiers (:sid . :s879.7) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008226@unknown@formal@none@1@S@In combination with TNF-alpha, IL-10 stimulated activating protein-1 (AP-1) and nuclear factor (NF)-kappa B binding activities and cooperated to increase HIV-1 steady-state mRNA levels and enhance long terminal repeat-directed transcription through activation of the NF-kappa B binding sites, suggesting the IL-10 effect occurs at least in part at the transcriptional level.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . 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"mRNA") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 184)\n  (:start . 178) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 196)\n  (:start . 189) (:id . 71))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 210)\n  (:start . 202) (:id . 73))\n ((:tag . "JJ") (:stem . "repeat-directed") (:form . "repeat-directed")\n  (:end . 226) (:start . 211) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 240) (:start . 227) (:id . 75))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 248)\n  (:start . 241) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 259)\n  (:start . 249) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 262) (:start . 260)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 266) (:start . 263)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 275)\n  (:start . 267) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 277) (:start . 276)\n  (:id . 81))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 285)\n  (:start . 278) (:id . 82))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 291)\n  (:start . 286) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 292) (:start . 291)\n  (:id . 84))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 303)\n  (:start . 293) (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 307) (:start . 304)\n  (:id . 86))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 313)\n  (:start . 308) (:id . 87))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 320)\n  (:start . 314) (:id . 88))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 327)\n  (:start . 321) (:id . 89))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 330) (:start . 328)\n  (:id . 90))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 336)\n  (:start . 331) (:id . 91))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 339) (:start . 337)\n  (:id . 92))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 344) (:start . 340)\n  (:id . 93))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 347) (:start . 345)\n  (:id . 94))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 351) (:start . 348)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 367) (:start . 352) (:id . 96))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 373)\n  (:start . 368) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 374) (:start . 373)\n  (:id . 98)))@@@1@57@((:hcues ((:id . :x879.8.1) (:span 293 303)))\n (:hscopes ((:id . :x879.8.1) (:span 293 373)))\n (:identifiers (:sid . :s879.8) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008227@unknown@formal@none@1@S@These results indicate that IL-10, in addition to down-regulating the cellular immune response to HIV-1, may also play a role in TNF-alpha-mediated activation of HIV-1 replication in the monocyte/macrophage lineage.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "down-regulate") (:form . "down-regulating")\n  (:end . 65) (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tnf-alpha-mediated") (:form . "TNF-alpha-mediated")\n  (:end . 147) (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 179)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 206) (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 214)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x879.9.1) (:span 105 108))\n  ((:id . :x879.9.2) (:span 14 27)))\n (:hscopes ((:id . :x879.9.1) (:span 105 214))\n  ((:id . :x879.9.2) (:span 14 214)))\n (:identifiers (:sid . :s879.9) (:did . :|8543841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008228@unknown@formal@none@1@S@The promoter and 5' flanking sequences controlling human B29 gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s880.1) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008230@unknown@formal@none@1@S@To better understand the regulation of this pivotal gene, we have analyzed the human genomic DNA sequence upstream of the B29 ATG start codon for transcriptional control activity.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B29") (:form . "B29") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "ATG") (:form . "ATG") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 161) (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s880.3) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008231@unknown@formal@none@1@S@The human B29 gene lacks either a TATA or a CAAT box and transcription is initiated at multiple sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CAAT") (:form . "CAAT") (:end . 48) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 101) (:start . 96)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x880.4.1) (:span 25 31 39 41)))\n (:ncues ((:id . :x880.4.3) (:span 19 24)))\n (:hscopes ((:id . :x880.4.1) (:span 25 48)))\n (:nscopes ((:id . :x880.4.3) (:span 19 52)))\n (:identifiers (:sid . :s880.4) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008232@unknown@formal@none@1@S@The minimal promoter of the human B29 gene is contained within a 193-bp region 5' of these multiple start sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "193-bp") (:form . "193-bp") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s880.5) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008233@unknown@formal@none@1@S@This minimal promoter exhibits B-cell-specific activity and contains SP1, ETS, OCT, and IKAROS/LYF-1 transcription factor motifs.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "exhibit") (:form . "exhibits") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 46) (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "OCT") (:form . "OCT") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ikaros/lyf-1") (:form . "IKAROS/LYF-1") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 121)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 128)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s880.6) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008234@unknown@formal@none@1@S@All these motifs are strikingly conserved in sequence and placement relative to the previously characterized murine B29 promoter.@(((:tag . "PDT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "strikingly") (:form . "strikingly") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "placement") (:form . "placement") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s880.7) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008235@unknown@formal@none@1@S@Additional upstream gene segments dramatically affected B29 minimal promoter activity.@(((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 46)\n  (:start . 34) (:id . 46))\n ((:tag . "VBD") (:stem . "affect") (:form . "affected") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 85)\n  (:start . 77) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s880.8) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008236@unknown@formal@none@1@S@A newly identified motif called the B29 conserved sequence (BCS), found upstream of both human and murine B29 promoters, appears to stimulate B29 transcription through a novel mechanism.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BCS") (:form . "BCS") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 105)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 119)\n  (:start . 110) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 159) (:start . 146) (:id . 69))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 167)\n  (:start . 160) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 175)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 185)\n  (:start . 176) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x880.9.1) (:span 121 128)))\n (:hscopes ((:id . :x880.9.1) (:span 0 185)))\n (:identifiers (:sid . :s880.9) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008237@unknown@formal@none@1@S@A single BCS had little effect either on the minimal B29 promoter or on a heterologous promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "bcs") (:form . "BCS") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 86)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s880.10) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008238@unknown@formal@none@1@S@Instead, the BCS stimulated transcription by counteracting 5' negative regulatory DNA sequences that block the activity of the B29 minimal promoter in its absence.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcs") (:form . "BCS") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "counteract") (:form . "counteracting") (:end . 58)\n  (:start . 45) (:id . 49))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "block") (:form . "block") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "b29") (:form . "B29") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 162)\n  (:start . 155) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s880.11) (:did . :|8555489|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008240@unknown@formal@none@1@S@MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells.@(((:tag . "NNP") (:stem . "MEK1") (:form . "MEK1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "signal-regulated") (:form . "signal-regulated")\n  (:end . 43) (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s881.1) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008241@unknown@formal@none@1@S@TCR engagement stimulates the activation of the protein kinase Raf-1.@(((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "Raf-1") (:form . "Raf-1") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s881.2) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008242@unknown@formal@none@1@S@Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases, ERK1 and ERK2.@(((:tag . "JJ") (:stem . "active") (:form . "Active") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "phosphorylate") (:form . "phosphorylates")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 63) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "kinase/extracellular")\n  (:form . "kinase/extracellular") (:end . 98) (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "signal-regulated") (:form . "signal-regulated")\n  (:end . 115) (:start . 99) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 122)\n  (:start . 116) (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 129)\n  (:start . 123) (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 131) (:start . 130)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MEK1") (:form . "MEK1") (:end . 137) (:start . 133)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 145)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "phosphorylate") (:form . "phosphorylates")\n  (:end . 168) (:start . 154) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 182)\n  (:start . 173) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "kinases/extracellular")\n  (:form . "kinases/extracellular") (:end . 212) (:start . 191) (:id . 70))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 219)\n  (:start . 213) (:id . 71))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 229)\n  (:start . 220) (:id . 72))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 237)\n  (:start . 230) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "ERK1") (:form . "ERK1") (:end . 243) (:start . 239)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "ERK2") (:form . "ERK2") (:end . 252) (:start . 248)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s881.3) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008243@unknown@formal@none@1@S@Raf-1 activity promotes IL-2 production in activated T lymphocytes.@(((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s881.4) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008244@unknown@formal@none@1@S@Therefore, we sought to determine whether MEK1 and ERK activities also stimulate IL-2 gene transcription.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 20) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "MEK1") (:form . "MEK1") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ERK") (:form . "ERK") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x881.5.1) (:span 34 41)))\n (:hscopes ((:id . :x881.5.1) (:span 34 104)))\n (:identifiers (:sid . :s881.5) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008245@unknown@formal@none@1@S@Expression of constitutively active Raf-1 or MEK1 in Jurkat T cells enhanced the stimulation of IL-2 promoter-driven transcription stimulated by a calcium ionophore and PMA, and together with a calcium ionophore the expression of each protein was sufficient to stimulate NF-AT activity.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mek1") (:form . "MEK1") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "promoter-driven") (:form . "promoter-driven")\n  (:end . 116) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 164)\n  (:start . 155) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 211)\n  (:start . 202) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 226)\n  (:start . 216) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 234) (:start . 230)\n  (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 242)\n  (:start . 235) (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 246) (:start . 243)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 257)\n  (:start . 247) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 260) (:start . 258)\n  (:id . 81))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 270)\n  (:start . 261) (:id . 82))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 276)\n  (:start . 271) (:id . 83))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 285)\n  (:start . 277) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s881.6) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008246@unknown@formal@none@1@S@Expression of MEK1-interfering mutants inhibited the stimulation of IL-2 promoter-driven transcription and blocked the ability of constitutively active Ras and Raf-1 to costimulate NF-AT activity with a calcium ionophore.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mek1-interfering") (:form . "MEK1-interfering")\n  (:end . 30) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 48)\n  (:start . 39) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 64)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "promoter-driven") (:form . "promoter-driven")\n  (:end . 88) (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 114)\n  (:start . 107) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 126)\n  (:start . 119) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 57))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 144) (:start . 130) (:id . 58))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 151)\n  (:start . 145) (:id . 59))\n ((:tag . "NN") (:stem . "ras") (:form . "Ras") (:end . 155) (:start . 152)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 61))\n ((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 165)\n  (:start . 160) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 63))\n ((:tag . "VB") (:stem . "costimulate") (:form . "costimulate") (:end . 180)\n  (:start . 169) (:id . 64))\n ((:tag . "NN") (:stem . "nf-at") (:form . "NF-AT") (:end . 186)\n  (:start . 181) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 195)\n  (:start . 187) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 68))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 210)\n  (:start . 203) (:id . 69))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 220)\n  (:start . 211) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s881.7) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008247@unknown@formal@none@1@S@Expression of the MAP kinase-specific phosphatase, MKP-1, which blocks ERK activation, inhibited IL-2 promoter and NF-AT-driven transcription stimulated by a calcium ionophore and PMA, and in addition, MKP-1 neutralized the transcriptional enhancement caused by active Raf-1 and MEK1 expression.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "kinase-specific") (:form . "kinase-specific")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mkp-1") (:form . "MKP-1") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "erk") (:form . "ERK") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nf-at-driven") (:form . "NF-AT-driven") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 61))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 175)\n  (:start . 166) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "mkp-1") (:form . "MKP-1") (:end . 207)\n  (:start . 202) (:id . 74))\n ((:tag . "VBD") (:stem . "neutralize") (:form . "neutralized") (:end . 219)\n  (:start . 208) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 239) (:start . 224) (:id . 77))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 251)\n  (:start . 240) (:id . 78))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 258)\n  (:start . 252) (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 261) (:start . 259)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 268)\n  (:start . 262) (:id . 81))\n ((:tag . "NN") (:stem . "raf-1") (:form . "Raf-1") (:end . 274)\n  (:start . 269) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 278) (:start . 275)\n  (:id . 83))\n ((:tag . "NN") (:stem . "mek1") (:form . "MEK1") (:end . 283) (:start . 279)\n  (:id . 84))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 294)\n  (:start . 284) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s881.8) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008248@unknown@formal@none@1@S@We conclude that the MAP kinase signal transduction pathway consisting of Raf-1, MEK1, and ERK1 and ERK2 functions in the stimulation IL-2 gene transcription in activated T lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Raf-1") (:form . "Raf-1") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MEK1") (:form . "MEK1") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "erk1") (:form . "ERK1") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "erk2") (:form . "ERK2") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 133)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 170)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 184)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s881.9) (:did . :|8557975|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5008252@unknown@formal@none@1@S@Immunoprecipitation of epitope-labeled BKO demonstrated for the formation of a tight complex with endogenous B subunit in Jurkat cells, consistent with an inhibitory mechanism that involves the sequestration of the B subunit.@(((:tag . "NNP") (:stem . "Immunoprecipitation")\n  (:form . "Immunoprecipitation") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "epitope-labeled") (:form . "epitope-labeled")\n  (:end . 38) (:start . 23) (:id . 44))\n ((:tag . "NN") (:stem . "bko") (:form . "BKO") (:end . 42) (:start . 39)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 55)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 73)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 118)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 165)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 175)\n  (:start . 166) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 180) (:start . 176)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 189)\n  (:start . 181) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 69))\n ((:tag . "NN") (:stem . "sequestration") (:form . "sequestration")\n  (:end . 207) (:start . 194) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 216) (:start . 215)\n  (:id . 73))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 224)\n  (:start . 217) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s882.4) (:did . :|8561779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008253@unknown@formal@none@1@S@Furthermore, the sharply reduced NF-AT activity produced by co-transfecting BKO could be "rescued" by overexpression of transfected B subunit, suggesting that depletion of this subunit was responsible for the inhibition.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "sharply") (:form . "sharply") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "co-transfecte") (:form . "co-transfecting")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "BKO") (:form . "BKO") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "\\"rescued") (:form . "\\"rescued") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 116) (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 131)\n  (:start . 120) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 153)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 168)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 176) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 184)\n  (:start . 177) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 200)\n  (:start . 189) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 219)\n  (:start . 209) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x882.5.1) (:span 143 153)))\n (:hscopes ((:id . :x882.5.1) (:span 143 219)))\n (:identifiers (:sid . :s882.5) (:did . :|8561779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008254@unknown@formal@none@1@S@These data suggest the potential utility of agents that disrupt calcineurin-mediated signal transduction pathways by blocking formation of the catalytically active dimer of calcineurin A and B subunits.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "utility") (:form . "utility") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "disrupt") (:form . "disrupt") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "calcineurin-mediated")\n  (:form . "calcineurin-mediated") (:end . 84) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 104)\n  (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 113)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 60))\n ((:tag . "RB") (:stem . "catalytically") (:form . "catalytically")\n  (:end . 156) (:start . 143) (:id . 61))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 163)\n  (:start . 157) (:id . 62))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 169)\n  (:start . 164) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 184)\n  (:start . 173) (:id . 65))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 186) (:start . 185)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 192) (:start . 191)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 201)\n  (:start . 193) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x882.6.1) (:span 23 32)) ((:id . :x882.6.2) (:span 11 18)))\n (:hscopes ((:id . :x882.6.1) (:span 23 201))\n  ((:id . :x882.6.2) (:span 11 201)))\n (:identifiers (:sid . :s882.6) (:did . :|8561779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008255@unknown@formal@none@1@S@Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "JJ") (:stem . "repeat-driven") (:form . "repeat-driven")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s883.1) (:did . :|8562512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008256@unknown@formal@none@1@S@Elevation of the levels of circulating immune complexes frequently accompanies HIV-1 infection and is a prognostic indicator of clinical progression from asymptomatic infection to AIDS.@(((:tag . "NNP") (:stem . "Elevation") (:form . "Elevation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "VBZ") (:stem . "accompany") (:form . "accompanies") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "prognostic") (:form . "prognostic") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "indicator") (:form . "indicator") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 136)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 148)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 153) (:start . 149)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "asymptomatic") (:form . "asymptomatic") (:end . 166)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 176)\n  (:start . 167) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 184) (:start . 180)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s883.2) (:did . :|8562512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008257@unknown@formal@none@1@S@Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . 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5008258@unknown@formal@none@1@S@In THP-1 cells, Fc gamma R cross-linking induced NF-kappa B, which is known to bind to the regulatory region of the long terminal repeat (LTR) of HIV-1 and to activate HIV-1 transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "r") (:form . "R") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 40) (:start . 27) (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 101)\n  (:start . 91) (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 108)\n  (:start . 102) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 136)\n  (:start . 130) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 141) (:start . 138)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 151)\n  (:start . 146) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 74))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 167)\n  (:start . 159) (:id . 75))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 173)\n  (:start . 168) (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 187) (:start . 174) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s883.4) (:did . :|8562512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008260@unknown@formal@none@1@S@These results indicate that Fc gamma R can mediate a TNF-alpha-dependent induction of HIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "r") (:form . "R") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tnf-alpha-dependent")\n  (:form . "TNF-alpha-dependent") (:end . 72) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 182) (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 191)\n  (:start . 186) (:id . 69))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 201)\n  (:start . 192) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "augment") (:form . "augmenting") (:end . 215)\n  (:start . 205) (:id . 72))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 221)\n  (:start . 216) (:id . 73))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 233)\n  (:start . 222) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 246)\n  (:start . 237) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x883.6.1) (:span 145 148))\n  ((:id . :x883.6.2) (:span 115 122)) ((:id . :x883.6.3) (:span 14 27)))\n (:hscopes ((:id . :x883.6.1) (:span 145 246))\n  ((:id . :x883.6.2) (:span 115 246)) ((:id . :x883.6.3) (:span 14 110)))\n (:identifiers (:sid . :s883.6) (:did . :|8562512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008261@unknown@formal@none@1@S@The effect of Toremifene on the expression of some genes in human mononuclear cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Toremifene") (:form . "Toremifene") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s884.1) (:did . :|8562886|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008262@unknown@formal@none@1@S@Toremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells.@(((:tag . "NNP") (:stem . "Toremifene") (:form . "Toremifene") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "varied") (:form . "varied") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 100)\n  (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s884.2) (:did . :|8562886|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008263@unknown@formal@none@1@S@After short-term, in vitro exposure to therapeutical levels, distinct changes in P-glycoprotein, steroid receptors, p53 and Bcl-2 expression take place.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "short-term") (:form . "short-term") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "therapeutical") (:form . "therapeutical")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "P-glycoprotein") (:form . "P-glycoprotein")\n  (:end . 95) (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "VBP") (:stem . "take") (:form . "take") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s884.3) (:did . :|8562886|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008264@unknown@formal@none@1@S@In view of the increasing use of antiestrogens in cancer therapy and prevention, there is obvious merit in long-term in vivo studies to be conducted.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 25)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "antiestrogen") (:form . "antiestrogens")\n  (:end . 46) (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "merit") (:form . "merit") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s884.4) (:did . :|8562886|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008265@unknown@formal@none@1@S@Identification of an ionomycin/cyclosporin A-responsive element within the human T cell receptor gamma enhancer.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ionomycin/cyclosporin")\n  (:form . "ionomycin/cyclosporin") (:end . 42) (:start . 21) (:id . 45))\n ((:tag . "JJ") (:stem . "a-responsive") (:form . "A-responsive") (:end . 55)\n  (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 63)\n  (:start . 56) (:id . 47))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 70)\n  (:start . 64) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 96)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s885.1) (:did . :|8566023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008266@unknown@formal@none@1@S@Activation through the Ca2+/calcineurin pathway is essential to the transcription of many cytokine genes.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ca2+/calcineurin") (:form . "Ca2+/calcineurin")\n  (:end . 39) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 47)\n  (:start . 40) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s885.2) (:did . :|8566023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008267@unknown@formal@none@1@S@The conserved cis-acting sequence, GGAAAA, and transcription factors binding to this sequence are involved in the response to increased intracellular Ca2+ concentrations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GGAAAA") (:form . "GGAAAA") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 149) (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 169) (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s885.3) (:did . :|8566023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008268@unknown@formal@none@1@S@Here we report the identification and importance of the same sequence in a non-cytokine gene, the human T cell receptor gamma (TCRG) enhancer.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 33) (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "non-cytokine") (:form . "non-cytokine") (:end . 87)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TCRG") (:form . "TCRG") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s885.4) (:did . :|8566023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008270@unknown@formal@none@1@S@Our studies provide an explanation for a previous observation that TCRG mRNA levels, but not mRNA levels for T cell receptor alpha and -beta, are increased by ionomycin treatment.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tcrg") (:form . "TCRG") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 155)\n  (:start . 146) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 168)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 178)\n  (:start . 169) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x885.6.1) (:span 89 92)))\n (:nscopes ((:id . :x885.6.1) (:span 89 140)))\n (:identifiers (:sid . :s885.6) (:did . :|8566023|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008271@unknown@formal@none@1@S@Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "anetholdithiolthione")\n  (:form . "anetholdithiolthione") (:end . 81) (:start . 61) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s886.1) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008272@unknown@formal@none@1@S@Nuclear factor (NF)-kappa B is a redox sensitive cytosolic transcription factor.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s886.2) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008273@unknown@formal@none@1@S@Redox regulation of NF-kappa B has been implicated in the activation of the human immuno-deficiency virus (HIV).@(((:tag . "NNP") (:stem . "Redox") (:form . "Redox") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immuno-deficiency") (:form . "immuno-deficiency")\n  (:end . 99) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s886.3) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008274@unknown@formal@none@1@S@Therefore, inhibition of NF-kappa B activation may be an effective strategy for acquired immunodeficiency syndrome therapy.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 105) (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x886.4.1) (:span 47 50)))\n (:hscopes ((:id . :x886.4.1) (:span 47 122)))\n (:identifiers (:sid . :s886.4) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008275@unknown@formal@none@1@S@Anetholdithiolthione (ADT, 5-[p-methoxyphenyl]-3H-1,2-dithiol-3-thione) is an antioxidant which has been used to protect against acetaminophen- and CCl4-induced hepatotoxicity, lipid peroxidation, radiation injury, and also has been used clinically as an anti-choleretic agent.@(((:tag . "NNP") (:stem . "Anetholdithiolthione")\n  (:form . "Anetholdithiolthione") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "5-[p-methoxyphenyl]-3H-1,2-dithiol-3-thione")\n  (:form . "5-[p-methoxyphenyl]-3H-1,2-dithiol-3-thione") (:end . 70)\n  (:start . 27) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 49))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 89)\n  (:start . 78) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 99) (:start . 96)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 104) (:start . 100)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 109) (:start . 105)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "VB") (:stem . "protect") (:form . "protect") (:end . 120)\n  (:start . 113) (:id . 56))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . "NN") (:stem . "acetaminophen-") (:form . "acetaminophen-")\n  (:end . 143) (:start . 129) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ccl4-induced") (:form . "CCl4-induced") (:end . 160)\n  (:start . 148) (:id . 60))\n ((:tag . "NN") (:stem . "hepatotoxicity") (:form . "hepatotoxicity")\n  (:end . 175) (:start . 161) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 182)\n  (:start . 177) (:id . 63))\n ((:tag . "NN") (:stem . "peroxidation") (:form . "peroxidation") (:end . 195)\n  (:start . 183) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 65))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 206)\n  (:start . 197) (:id . 66))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 213)\n  (:start . 207) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 218) (:start . 215)\n  (:id . 69))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 223) (:start . 219)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 227) (:start . 224)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 232) (:start . 228)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 237) (:start . 233)\n  (:id . 73))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 248)\n  (:start . 238) (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 251) (:start . 249)\n  (:id . 75))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 254) (:start . 252)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "anti-choleretic") (:form . "anti-choleretic")\n  (:end . 270) (:start . 255) (:id . 77))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 276)\n  (:start . 271) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s886.5) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008276@unknown@formal@none@1@S@The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 57)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 140)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 150)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 158)\n  (:start . 151) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 173)\n  (:start . 168) (:id . 73))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 189)\n  (:start . 183) (:id . 75))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 195)\n  (:start . 190) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 200) (:start . 197)\n  (:id . 78))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 206)\n  (:start . 201) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s886.6) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008277@unknown@formal@none@1@S@PMA and TNF alpha induced activation of (NF)-kappa B in human Jurkat T-cells was partially inhibited by ADT (0.1 mM) pretreatment.@(((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 129)\n  (:start . 117) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s886.7) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008278@unknown@formal@none@1@S@ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells.@(((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 12) (:start . 11)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 27)\n  (:start . 18) (:id . 48))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 40)\n  (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s886.8) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008280@unknown@formal@none@1@S@H2O2 induced lipid peroxidation in Wurzburg cells was remarkably inhibited by ADT pretreatment.@(((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "peroxidation") (:form . "peroxidation") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "remarkably") (:form . "remarkably") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 94)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s886.10) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008281@unknown@formal@none@1@S@ADT, a pro-glutathione antioxidant, was observed to be capable of modulating NF-kappa B activation.@(((:tag . "NNP") (:stem . "ADT") (:form . "ADT") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pro-glutathione") (:form . "pro-glutathione")\n  (:end . 22) (:start . 7) (:id . 45))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s886.11) (:did . :|8573121|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008282@unknown@formal@none@1@S@In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "anergize") (:form . "anergized") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBN") (:stem . "perturb") (:form . "perturbed") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s887.1) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008283@unknown@formal@none@1@S@Anergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult.@(((:tag . "NNP") (:stem . "Anergy") (:form . "Anergy") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "antigen-specific") (:form . "antigen-specific")\n  (:end . 54) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adult") (:form . "adult") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s887.2) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008284@unknown@formal@none@1@S@In vivo, anergy has mainly been studied at the cellular level.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s887.3) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008285@unknown@formal@none@1@S@In this study, we used the T-cell-activating superantigen staphylococcal enterotoxin A (SEA) to investigate molecular mechanisms of T-lymphocyte anergy in vivo.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "t-cell-activating") (:form . "T-cell-activating")\n  (:end . 44) (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "superantigen") (:form . "superantigen") (:end . 57)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 72) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "enterotoxin") (:form . "enterotoxin") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SEA") (:form . "SEA") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 144) (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 151)\n  (:start . 145) (:id . 63))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s887.4) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008286@unknown@formal@none@1@S@Injection of SEA to adult mice activates CD4+ T cells expressing certain T-cell receptor (TCR) variable region beta-chain families and induces strong and rapid production of interleukin 2 (IL-2).@(((:tag . "NN") (:stem . "injection") (:form . "Injection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SEA") (:form . "SEA") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 110)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 142)\n  (:start . 135) (:id . 64))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 185)\n  (:start . 174) (:id . 70))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s887.5) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008287@unknown@formal@none@1@S@In contrast, repeated injections of SEA cause CD4+ T-cell deletion and anergy in the remaining CD4+ T cells, characterized by reduced expression of IL-2 at mRNA and protein levels.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "injection") (:form . "injections") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SEA") (:form . "SEA") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "anergy") (:form . "anergy") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 122) (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 172)\n  (:start . 165) (:id . 71))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 179)\n  (:start . 173) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s887.6) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008288@unknown@formal@none@1@S@We analyzed expression of AP-1, NF-kappa B, NF-AT, and octamer binding transcription factors, which are known to be involved in the regulation of IL-2 gene promoter activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 142)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 150) (:start . 146)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 155) (:start . 151)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 164)\n  (:start . 156) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 173)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s887.7) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008290@unknown@formal@none@1@S@In contrast, anergic CD4+ T cells contained severely reduced levels of AP-1 and Fos/Jun-containing NF-AT complexes but expressed significant amounts of NF-kappa B and Oct binding proteins after SEA stimulation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fos/jun-containing") (:form . "Fos/Jun-containing")\n  (:end . 98) (:start . 80) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 187)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 193)\n  (:start . 188) (:id . 70))\n ((:tag . "NNP") (:stem . "SEA") (:form . "SEA") (:end . 197) (:start . 194)\n  (:id . 71))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 209)\n  (:start . 198) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s887.9) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008291@unknown@formal@none@1@S@Resolution of the NF-kappa B complex demonstrated predominant expression of p50-p65 heterodimers in activated CD4+ T cells, while anergic cells mainly expressed the transcriptionally inactive p50 homodimer.@(((:tag . "NNP") (:stem . "Resolution") (:form . "Resolution") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 96)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 182) (:start . 165) (:id . 66))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 191)\n  (:start . 183) (:id . 67))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 195) (:start . 192)\n  (:id . 68))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 205)\n  (:start . 196) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s887.10) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008292@unknown@formal@none@1@S@These alterations of transcription factors are likely to be responsible for repression of IL-2 in anergic T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anergic") (:form . "anergic") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x887.11.1) (:span 47 53)))\n (:hscopes ((:id . :x887.11.1) (:span 0 113)))\n (:identifiers (:sid . :s887.11) (:did . :|8577772|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008293@unknown@formal@none@1@S@Surfactant suppresses NF-kappa B activation in human monocytic cells.@(((:tag . "NNP") (:stem . "Surfactant") (:form . "Surfactant") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s888.1) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008294@unknown@formal@none@1@S@In addition to biophysical properties, pulmonary surfactant has immunomodulatory activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "biophysical") (:form . "biophysical") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "surfactant") (:form . "surfactant") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 80) (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s888.2) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008295@unknown@formal@none@1@S@We previously demonstrated that both synthetic (Exosurf) and modified natural surfactant (Survanta) downregulated endotoxin-stimulated inflammatory c ytokine mRNA levels and protein products (tumor necrosis factor-alpha [TNF], interleukin-1-beta [IL-1], interleukin-6 [IL-6]) in human alveolar macrophages.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . 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5008296@unknown@formal@none@1@S@In this study, we report that both Exosurf and Survanta suppress TNF mRNA and secretion (85 ± 4% mean percent inhibition ± SEM by Exosurf; 71 ± 6% by Survanta) by endotoxin-stimulated THP-1, a human monocytic cell line.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Exosurf") (:form . "Exosurf") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Survanta") (:form . "Survanta") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "CD") (:stem . "85") (:form . "85") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . ".") (:stem . "±") (:form . "±") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 96) (:start . 95)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 101) (:start . 97)\n  (:id . 63))\n ((:tag . "NN") (:stem . "percent") (:form . "percent") (:end . 109)\n  (:start . 102) (:id . 64))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 120)\n  (:start . 110) (:id . 65))\n ((:tag . "NNP") (:stem . "±") (:form . "±") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "SEM") (:form . "SEM") (:end . 126) (:start . 123)\n  (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Exosurf") (:form . "Exosurf") (:end . 137)\n  (:start . 130) (:id . 69))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 138) (:start . 137)\n  (:id . 70))\n ((:tag . "CD") (:stem . "71") (:form . "71") (:end . 141) (:start . 139)\n  (:id . 71))\n ((:tag . "CC") (:stem . "±") (:form . "±") (:end . 143) (:start . 142)\n  (:id . 72))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 145) (:start . 144)\n  (:id . 73))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 146) (:start . 145)\n  (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Survanta") (:form . "Survanta") (:end . 158)\n  (:start . 150) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "endotoxin-stimulated")\n  (:form . "endotoxin-stimulated") (:end . 183) (:start . 163) (:id . 79))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 189)\n  (:start . 184) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 192) (:start . 191)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 198)\n  (:start . 193) (:id . 83))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 208)\n  (:start . 199) (:id . 84))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 213) (:start . 209)\n  (:id . 85))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 218) (:start . 214)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s888.4) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008297@unknown@formal@none@1@S@Because surfactant downregulated inflammatory cytokine production similarly in both normal human alveolar macrophages and the THP-1 cell line, we used this cell line to investigate whether surfactant affected transcriptional mechanisms.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "surfactant") (:form . "surfactant") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "downregulate") (:form . "downregulated")\n  (:end . 32) (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 45)\n  (:start . 33) (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 54)\n  (:start . 46) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 65)\n  (:start . 55) (:id . 47))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 75)\n  (:start . 66) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 83) (:start . 79)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 105)\n  (:start . 97) (:id . 53))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 117)\n  (:start . 106) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 56))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 131)\n  (:start . 126) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 145) (:start . 143)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 180)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "JJ") (:stem . "surfactant") (:form . "surfactant") (:end . 199)\n  (:start . 189) (:id . 69))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 208)\n  (:start . 200) (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 224) (:start . 209) (:id . 71))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 235)\n  (:start . 225) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x888.5.1) (:span 181 188)))\n (:hscopes ((:id . :x888.5.1) (:span 181 235)))\n (:identifiers (:sid . :s888.5) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008298@unknown@formal@none@1@S@Specifically, we examined nuclear factor-kappa B (NF-kappa B) activation because it is crucial in transcriptional regulation of many inflammatory cytokine genes including TNF, IL-1, and IL-6.@(((:tag . "RB") (:stem . "specifically") (:form . "Specifically") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 113) (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 145)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 170)\n  (:start . 161) (:id . 66))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s888.6) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008300@unknown@formal@none@1@S@The presence of both p65 and p50 NF-kappa B components in LPS-activated THP-1 cells was confirmed by specific antibody induction of supershifts in mobility assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lps-activated") (:form . "LPS-activated")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "supershift") (:form . "supershifts") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s888.8) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008301@unknown@formal@none@1@S@These results are the first to suggest that surfactant's suppressive effects on inflammatory cytokine production may involve transcriptional regulation through inhibition of NF-kappa B activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surfactant") (:form . "surfactant") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 92)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 140) (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 151)\n  (:start . 141) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 159)\n  (:start . 152) (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 170)\n  (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 184) (:start . 183)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 195)\n  (:start . 185) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x888.9.1) (:span 113 116))\n  ((:id . :x888.9.2) (:span 31 38)))\n (:hscopes ((:id . :x888.9.1) (:span 113 195))\n  ((:id . :x888.9.2) (:span 31 195)))\n (:identifiers (:sid . :s888.9) (:did . :|8600942|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008302@unknown@formal@none@1@S@A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p [see comments]@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 68) (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NNP") (:stem . "Rpd3p") (:form . "Rpd3p") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s889.1) (:did . :|8602529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008303@unknown@formal@none@1@S@Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle.@(((:tag . "NNP") (:stem . "Trapoxin") (:form . "Trapoxin") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "microbially") (:form . "microbially") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "cyclotetrapeptide") (:form . "cyclotetrapeptide")\n  (:end . 51) (:start . 34) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "deacetylation") (:form . "deacetylation")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 116)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "VB") (:stem . "arrest") (:form . "arrest") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s889.2) (:did . :|8602529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008304@unknown@formal@none@1@S@A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "trapoxin") (:form . "trapoxin") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "copurifie") (:form . "copurified") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s889.3) (:did . :|8602529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008305@unknown@formal@none@1@S@Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "microsequencing") (:form . "microsequencing")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 114)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 132)\n  (:start . 125) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HD1") (:form . "HD1") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 169)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 184)\n  (:start . 177) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s889.4) (:did . :|8602529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008306@unknown@formal@none@1@S@As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 69) (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "Rpd3p") (:form . "Rpd3p") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "deacetylase") (:form . "deacetylase") (:end . 139)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 172)\n  (:start . 162) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 186) (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s889.5) (:did . :|8602529|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008307@unknown@formal@none@1@S@Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31.@(((:tag . "NN") (:stem . "coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-13") (:form . "interleukin-13")\n  (:end . 34) (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 80)\n  (:start . 75) (:id . 51))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "linkage") (:form . "linkage") (:end . 97)\n  (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 146)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "5q23-31") (:form . "5q23-31") (:end . 154)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s890.1) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008308@unknown@formal@none@1@S@Interleukin-13 (IL-13) and IL-4 are cytokines produced by T cells that are encoded by the q23-31 region of human chromosome 5.@(((:tag . "NNP") (:stem . "Interleukin-13") (:form . "Interleukin-13")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "q23-31") (:form . "q23-31") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s890.2) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008310@unknown@formal@none@1@S@The human IL-13 gene was located 12.5-kb upstream of the IL-4 gene and 2-kb downstream of a CpG island.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "12.5-kb") (:form . "12.5-kb") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "upstream") (:form . "upstream") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "2-kb") (:form . "2-kb") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CpG") (:form . "CpG") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "island") (:form . "island") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s890.4) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008311@unknown@formal@none@1@S@The IL-13 gene 5' flank region included a segment with sequence homology to P elements of the IL-4 promoter involved in transcriptional activation in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "flank") (:form . "flank") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 30)\n  (:start . 24) (:id . 48))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 98) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 135) (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s890.5) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008312@unknown@formal@none@1@S@Mutation of the IL-13 P element site significantly reduced IL-13 promoter activity in response to T-cell activation.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 50) (:start . 37) (:id . 49))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s890.6) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008313@unknown@formal@none@1@S@Oligonucleotides containing the IL-13 or IL-4 P element sites specifically bound the transcriptional activator protein, nuclear factor-activated T cells, preformed (NF-ATp), when incubated with nuclear protein extracts from activated T cells.@(((:tag . "NNS") (:stem . "oligonucleotide") (:form . "Oligonucleotides")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 37) (:start . 32)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 118)\n  (:start . 111) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "JJ") (:stem . "factor-activated") (:form . "factor-activated")\n  (:end . 144) (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "preformed") (:form . "preformed") (:end . 163)\n  (:start . 154) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-ATp") (:form . "NF-ATp") (:end . 171)\n  (:start . 165) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 201)\n  (:start . 194) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 209)\n  (:start . 202) (:id . 72))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 218)\n  (:start . 210) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 233)\n  (:start . 224) (:id . 75))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 235) (:start . 234)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 241)\n  (:start . 236) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s890.7) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008314@unknown@formal@none@1@S@Similar to IL-4, IL-13 mRNA expression was highest in T-cell populations enriched for cells that had previously been primed in vivo or in vitro, indicating that priming increases the expression of the IL-13 and IL-4 genes in a coordinate manner.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-13") (:form . "IL-13") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 168)\n  (:start . 161) (:id . 70))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 178)\n  (:start . 169) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 193)\n  (:start . 183) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 206)\n  (:start . 201) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 77))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 215) (:start . 211)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 221)\n  (:start . 216) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 226) (:start . 225)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 237)\n  (:start . 227) (:id . 82))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 244)\n  (:start . 238) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x890.8.1) (:span 145 160)))\n (:hscopes ((:id . :x890.8.1) (:span 145 244)))\n (:identifiers (:sid . :s890.8) (:did . :|8605348|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008315@unknown@formal@none@1@S@Because the primed T cells contain higher levels of nuclear NF-ATp, capable of binding to P elements of the IL-4 and IL-13 promoters, than do freshly-isolated T cells, the NF-AT-binding P elements are attractive candidates to mediate the coordinate expression of these two cytokine genes.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 41) (:start . 35)\n  (:id . 48))\n ((:tag . 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5008316@unknown@formal@none@1@S@Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-1alpha") (:form . "interleukin-1alpha")\n  (:end . 41) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s891.1) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008317@unknown@formal@none@1@S@Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-1alpha (IL-1alpha).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "HTLV-I)-infected") (:form . "HTLV-I)-infected")\n  (:end . 52) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 80) (:start . 66) (:id . 52))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-1alpha") (:form . "interleukin-1alpha")\n  (:end . 122) (:start . 104) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s891.2) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008318@unknown@formal@none@1@S@To analyze the mechanisms that lead to the expression of IL-1alpha in HTLV-I-infected cell lines, we studied regulatory regions of the human IL-1alpha promoter involved in activation of the IL-1alpha gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "htlv-i-infected") (:form . "HTLV-I-infected")\n  (:end . 85) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 199)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 204) (:start . 200)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s891.3) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008320@unknown@formal@none@1@S@In a cotransfection assay, the Tax protein of both HTLV-I and HTLV-II specifically activated transcription from the IL-1alpha promoter in an uninfected Jurkat cell line.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 19) (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HTLV-II") (:form . "HTLV-II") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 82)\n  (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 151)\n  (:start . 141) (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 168) (:start . 164)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s891.5) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008321@unknown@formal@none@1@S@A mutant Tax protein deficient in transactivation of genes by the nuclear factor (NF)-kappaB pathway was unable to induce transcriptional activity of IL-1alpha promoter-CAT constructs, but was rescued by exogenous provision of p65/p50 NF-kappaB.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 49) (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 137) (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 146)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "promoter-cat") (:form . "promoter-CAT") (:end . 172)\n  (:start . 160) (:id . 66))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 183)\n  (:start . 173) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 188) (:start . 185)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 213)\n  (:start . 204) (:id . 73))\n ((:tag . "NN") (:stem . "provision") (:form . "provision") (:end . 223)\n  (:start . 214) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 75))\n ((:tag . "NN") (:stem . "p65/p50") (:form . "p65/p50") (:end . 234)\n  (:start . 227) (:id . 76))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 244)\n  (:start . 235) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x891.6.1) (:span 105 111)))\n (:nscopes ((:id . :x891.6.1) (:span 0 183)))\n (:identifiers (:sid . :s891.6) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008322@unknown@formal@none@1@S@We found that two IL-1alpha kappaB-like sites (positions -1,065 to -1,056 and +646 to +655) specifically formed a complex with NF-kappaB-containing nuclear extract from MT-2 cells and that NF-kappaB bound with higher affinity to the 3' NF-kappaB binding site than to the 5' NF-kappaB site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "kappab-like") (:form . "kappaB-like") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "CD") (:stem . "-1,065") (:form . "-1,065") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-1,056") (:form . "-1,056") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "CD") (:stem . "+646") (:form . "+646") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "+655") (:form . "+655") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "specifically") (:form . 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"cells") (:end . 179)\n  (:start . 174) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 198)\n  (:start . 189) (:id . 72))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 204)\n  (:start . 199) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 216)\n  (:start . 210) (:id . 75))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 225)\n  (:start . 217) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 228) (:start . 226)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 78))\n ((:tag . "CD") (:stem . "3") (:form . 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5008323@unknown@formal@none@1@S@Moreover, deletion of either 5' or 3' NF-kappaB sites reduced IL-1alpha promoter activity in MT-2 cells and transactivation of the IL-1alpha promoter by exogenous NF-kappaB and Tax in Jurkat cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 37) (:start . 36)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 47)\n  (:start . 38) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 61)\n  (:start . 54) (:id . 54))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 71)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mt-2") (:form . "MT-2") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 123) (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 162)\n  (:start . 153) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 190)\n  (:start . 184) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s891.8) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008324@unknown@formal@none@1@S@These data suggest a general role for Tax induction of IL-1alpha gene transcription by the NF-kappaB pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x891.9.1) (:span 11 18)))\n (:hscopes ((:id . :x891.9.1) (:span 11 108)))\n (:identifiers (:sid . :s891.9) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008325@unknown@formal@none@1@S@Expression of IL-1alpha by HTLV-I productively infected cells may be important in the hypercalcemia, osteolytic bone lesions, neutrophilia, elevation of C-reactive protein, and fever frequently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-1alpha") (:form . "IL-1alpha") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "RB") (:stem . "productively") (:form . "productively") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hypercalcemia") (:form . "hypercalcemia")\n  (:end . 99) (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "osteolytic") (:form . "osteolytic") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "neutrophilia") (:form . "neutrophilia") (:end . 138)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "c-reactive") (:form . "C-reactive") (:end . 163)\n  (:start . 153) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 171)\n  (:start . 164) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 198) (:start . 194)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 210)\n  (:start . 202) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 215) (:start . 211)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "htlv-i-induced") (:form . "HTLV-I-induced")\n  (:end . 230) (:start . 216) (:id . 75))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 236)\n  (:start . 231) (:id . 76))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 243)\n  (:start . 237) (:id . 77))\n ((:tag . "NN") (:stem . "leukemia/lymphoma") (:form . "leukemia/lymphoma")\n  (:end . 261) (:start . 244) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x891.10.1) (:span 62 65)))\n (:hscopes ((:id . :x891.10.1) (:span 62 261)))\n (:identifiers (:sid . :s891.10) (:did . :|8605359|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008326@unknown@formal@none@1@S@Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells.@(((:tag . "JJ") (:stem . "soluble") (:form . "Soluble") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 94) (:start . 78) (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 100)\n  (:start . 95) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 54))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 123)\n  (:start . 112) (:id . 55))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 132)\n  (:start . 124) (:id . 56))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 135) (:start . 133)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s892.1) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008327@unknown@formal@none@1@S@Recombinant human tumor necrosis factor (TNF) binding protein-1 (r-h TBP-1) and recombinant human soluble dimeric TNF receptor (rhu TNFR:Fc) were used to determine the relative contributions of TNF to phorbol myristate acetate (PMA) and cytokine-induced human immunodeficiency virus type 1 (HIV-1) replication in chronically infected cell lines.@(((:tag . "JJ") (:stem . "recombinant") (:form . "Recombinant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF") (:form . 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5008328@unknown@formal@none@1@S@Treatment of HIV-1-infected promonocytic U1 cells with r-h-TBP-1 or rhu TNFR:Fc reduced PMA-induced HIV-1 p24 antigen production in a concentration-dependent manner, with a maximal inhibition of approximately 90%.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 40)\n  (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "r-h-tbp-1") (:form . "r-h-TBP-1") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rhu") (:form . "rhu") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNFR:Fc") (:form . "TNFR:Fc") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 99)\n  (:start . 88) (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 128)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 157) (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 164)\n  (:start . 158) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 180)\n  (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 191)\n  (:start . 181) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 68))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 208) (:start . 195) (:id . 69))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 211) (:start . 209)\n  (:id . 70))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 212) (:start . 211)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s892.3) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008330@unknown@formal@none@1@S@r-hTBP-1 and rhu TNFR:Fc also decreased p24 antigen synthesized by U1 cells in response to other stimuli, including phytohemagglutinin (PHA)-induced supernatant, granulocyte-macrophage colony-stimulating factor, interleukin-6, and TNF.@(((:tag . "NN") (:stem . "r-htbp-1") (:form . "r-hTBP-1") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "rhu") (:form . "rhu") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNFR:Fc") (:form . "TNFR:Fc") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 134) (:start . 116) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "PHA)-induced") (:form . "PHA)-induced")\n  (:end . 148) (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "supernatant") (:form . "supernatant") (:end . 160)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 184) (:start . 162) (:id . 66))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 203) (:start . 185) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 210)\n  (:start . 204) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 225) (:start . 212) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 234) (:start . 231)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s892.5) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008331@unknown@formal@none@1@S@Addition of r-hTBP-1 to U1 cells during the last 4 h of a 24 h incubation with PMA still inhibited p24 antigen production by 15%.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "r-htbp-1") (:form . "r-hTBP-1") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 60) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 73)\n  (:start . 63) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 98)\n  (:start . 89) (:id . 61))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 110)\n  (:start . 103) (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 121)\n  (:start . 111) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s892.6) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008332@unknown@formal@none@1@S@U1 cells stimulated with 10(-7) M PMA released approximately 1 ng/ml endogenous TBP-1 with an initial peak observed at 1 h and a second peak at 24 h after PMA stimulation.@(((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "10(-7)") (:form . "10(-7)") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "release") (:form . "released") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "tbp-1") (:form . "TBP-1") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 135)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 154)\n  (:start . 149) (:id . 70))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 170)\n  (:start . 159) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s892.7) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008333@unknown@formal@none@1@S@r-hTBP-1 also partially reversed inhibition of U1 cellular proliferation caused by PMA.@(((:tag . "NN") (:stem . "r-htbp-1") (:form . "r-hTBP-1") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "reverse") (:form . "reversed") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s892.8) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008334@unknown@formal@none@1@S@Both r-hTBP-1 and rhu TNFR:Fc blocked PMA induction of nuclear factor (NK)- kappa B DNA-binding activity in U1 cells in association with decreases in HIV-1 replication.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "r-htbp-1") (:form . "r-hTBP-1") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rhu") (:form . "rhu") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNFR:Fc") (:form . "TNFR:Fc") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "FW") (:stem . "NK)-") (:form . "NK)-") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 131)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 167)\n  (:start . 156) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s892.9) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008335@unknown@formal@none@1@S@We conclude that soluble TNF receptors can inhibit stimuli-induced HIV-1 expression and NK- kappa B DNA-binding activity in chronically infected U1 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "stimuli-induced") (:form . "stimuli-induced")\n  (:end . 66) (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nk-") (:form . "NK-") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 135)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s892.10) (:did . :|8605587|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008336@unknown@formal@none@1@S@AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.@(((:tag . "NNP") (:stem . "AM580") (:form . "AM580") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "benzoic") (:form . "benzoic") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "JJ") (:stem . "cyto-differentiating")\n  (:form . "cyto-differentiating") (:end . 100) (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s893.1) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008337@unknown@formal@none@1@S@All-trans retinoic acid (ATRA) is successfully used in the cyto-differentiating treatment of acute promyelocytic leukemia (APL).@(((:tag . "JJ") (:stem . "all-trans") (:form . "All-trans") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 46)\n  (:start . 34) (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cyto-differentiating")\n  (:form . "cyto-differentiating") (:end . 79) (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s893.2) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008338@unknown@formal@none@1@S@Paradoxically, APL cells express PML-RAR, an aberrant form of the retinoic acid receptor type alpha (RAR alpha) derived from the leukemia-specific t(15;17) chromosomal translocation.@(((:tag . "RB") (:stem . "paradoxically") (:form . "Paradoxically")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "PML-RAR") (:form . "PML-RAR") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 124) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "leukemia-specific") (:form . "leukemia-specific")\n  (:end . 146) (:start . 129) (:id . 66))\n ((:tag . "JJ") (:stem . "t(15;17)") (:form . "t(15;17)") (:end . 155)\n  (:start . 147) (:id . 67))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 167)\n  (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 181) (:start . 168) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s893.3) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008340@unknown@formal@none@1@S@After treatment of APL cells with AM580 either alone or in combination with granulocyte colony-stimulating factor (G-CSF), the compound induces granulocytic maturation, as assessed by determination of the levels of leukocyte alkaline phosphatase, CD11b, CD33, and G-CSF receptor mRNA, at concentrations that are 10- to 100-fold lower than those of ATRA necessary to produce similar effects.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "APL") (:form . "APL") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . 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5008341@unknown@formal@none@1@S@By contrast, AM580 is not effective as ATRA in modulating the expression of these differentiation markers in the HL-60 cell line and in freshly isolated granulocytes obtained from the peripheral blood of chronic myelogenous leukemia patients during the stable phase of the disease.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AM580") (:form . "AM580") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 97) (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 165)\n  (:start . 153) (:id . 68))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 200)\n  (:start . 195) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 211)\n  (:start . 204) (:id . 75))\n ((:tag . "JJ") (:stem . "myelogenous") (:form . "myelogenous") (:end . 223)\n  (:start . 212) (:id . 76))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 232)\n  (:start . 224) (:id . 77))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 241)\n  (:start . 233) (:id . 78))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 248)\n  (:start . 242) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 252) (:start . 249)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 259)\n  (:start . 253) (:id . 81))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 265)\n  (:start . 260) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 268) (:start . 266)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 272) (:start . 269)\n  (:id . 84))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 280)\n  (:start . 273) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x893.6.1) (:span 22 25)))\n (:nscopes ((:id . :x893.6.1) (:span 22 280)))\n (:identifiers (:sid . :s893.6) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008342@unknown@formal@none@1@S@In NB4 cells, two other synthetic nonselective RAR ligands are capable of inducing LAP as much as AM580, whereas RAR beta- or RAR gamma-specific ligands are totally ineffective.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 33)\n  (:start . 24) (:id . 48))\n ((:tag . "JJ") (:stem . "nonselective") (:form . "nonselective") (:end . 46)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NNP") (:stem . "LAP") (:form . "LAP") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "AM580") (:form . "AM580") (:end . 103)\n  (:start . 98) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta-") (:form . "beta-") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "gamma-specific") (:form . "gamma-specific")\n  (:end . 144) (:start . 130) (:id . 67))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 164)\n  (:start . 157) (:id . 70))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 176)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s893.7) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008343@unknown@formal@none@1@S@These results show that AM580 is more powerful than ATRA in modulating the expression of differentiation antigens only in cells in which PML-RAR is present.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "am580") (:form . "AM580") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 104) (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "NNP") (:stem . "PML-RAR") (:form . "PML-RAR") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s893.8) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008344@unknown@formal@none@1@S@Binding experiments, using COS-7 cells transiently transfected with PML-RAR and the normal RAR alpha, show that AM580 has a lower affinity than ATRA for both receptors.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cos-7") (:form . "COS-7") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PML-RAR") (:form . "PML-RAR") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "rar") (:form . "RAR") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "AM580") (:form . "AM580") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 129) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s893.9) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008345@unknown@formal@none@1@S@However, in the presence of PML-RAR, the synthetic retinoid is a much better transactivator of retinoic acid-responsive element-containing promoters than the natural retinoid, whereas, in the presence of RAR alpha, AM580 and ATRA have similar activity.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PML-RAR") (:form . "PML-RAR") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 76) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 91) (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "acid-responsive") (:form . "acid-responsive")\n  (:end . 119) (:start . 104) (:id . 60))\n ((:tag . "JJ") (:stem . "element-containing") (:form . "element-containing")\n  (:end . 138) (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 67))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 213)\n  (:start . 208) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "AM580") (:form . "AM580") (:end . 220)\n  (:start . 215) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 229) (:start . 225)\n  (:id . 79))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 234) (:start . 230)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 242)\n  (:start . 235) (:id . 81))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 251)\n  (:start . 243) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s893.10) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008346@unknown@formal@none@1@S@This may explain the strong cyto-differentiating potential of AM580 in PML-RAR-containing leukemic cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "cyto-differentiating")\n  (:form . "cyto-differentiating") (:end . 48) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "am580") (:form . "AM580") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pml-rar-containing") (:form . "PML-RAR-containing")\n  (:end . 89) (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x893.11.1) (:span 5 8)))\n (:hscopes ((:id . :x893.11.1) (:span 5 104)))\n (:identifiers (:sid . :s893.11) (:did . :|8608243|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008347@unknown@formal@none@1@S@Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 21) (:start . 16)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hyporesponsiveness") (:form . "hyporesponsiveness")\n  (:end . 44) (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 74)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lipopolysaccharide/interferon-gamma")\n  (:form . "lipopolysaccharide/interferon-gamma") (:end . 133) (:start . 98)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s894.1) (:did . :|8613707|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008348@unknown@formal@none@1@S@The work reported here resolves, at the level of gene regulation, the controversy as to whether or not human monocytes/macrophages can produce nitric oxide (NO) when stimulated with lipopolysaccharide (LPS), with or without co-stimulation by interferon-gamma (IFN-gamma).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "resolve") (:form . "resolves") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . 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5008350@unknown@formal@none@1@S@Two explanations for hyporesponsiveness of the human iNOS promoter to LPS ± IFN-gamma were found: (1) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate LPS/IFN-gamma induced expression of the mouse iNOS gene; and (2) and absence of one or more nuclear factors in human macrophages (e.g., an LPS-inducible nuclear factor-kappa B/Rel complex), that is (are) required for maximal expression of the gene.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "explanation") (:form . "explanations") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hyporesponsiveness") (:form . "hyporesponsiveness")\n  (:end . 39) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . 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5008351@unknown@formal@none@1@S@The importance of resolution of this controversy is that future research in this area should be directed toward the understanding of alternative mechanisms that can result in the successful production of NO.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "resolution") (:form . "resolution") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "controversy") (:form . "controversy") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 129) (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 144)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 171)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 189)\n  (:start . 179) (:id . 70))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 200)\n  (:start . 190) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x894.5.1) (:span 161 164))\n  ((:id . :x894.5.2) (:span 86 92)))\n (:hscopes ((:id . :x894.5.1) (:span 161 206))\n  ((:id . :x894.5.2) (:span 0 206)))\n (:identifiers (:sid . :s894.5) (:did . :|8613707|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008352@unknown@formal@none@1@S@GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.@(((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "associate") (:form . "associate") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 73) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 109) (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s895.1) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008353@unknown@formal@none@1@S@The nuclear distribution of GATA transcription factors in murine haemopoietic cells was examined by indirect immunofluorescence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "haemopoietic") (:form . "haemopoietic") (:end . 77)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 127) (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s895.2) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008354@unknown@formal@none@1@S@Specific bright foci of GATA-1 fluorescence were observed in erythroleukaemia cells and primary murine erythroblasts and megakaryocytes, in addition to diffuse nucleoplasmic localization.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "bright") (:form . "bright") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "focus") (:form . "foci") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "erythroleukaemia") (:form . "erythroleukaemia")\n  (:end . 77) (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 116) (:start . 103) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 135) (:start . 121) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 148)\n  (:start . 140) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "VB") (:stem . "diffuse") (:form . "diffuse") (:end . 159)\n  (:start . 152) (:id . 63))\n ((:tag . "JJ") (:stem . "nucleoplasmic") (:form . "nucleoplasmic")\n  (:end . 173) (:start . 160) (:id . 64))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 186)\n  (:start . 174) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s895.3) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008355@unknown@formal@none@1@S@These foci, which were preferentially found adjacent to nucleoli or at the nuclear periphery, did not represent sites of active transcription or binding of GATA-1 to consensus sites in the beta-globin loci.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "focus") (:form . "foci") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 37) (:start . 23) (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "nucleolus") (:form . "nucleoli") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "periphery") (:form . "periphery") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 162)\n  (:start . 156) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 175)\n  (:start . 166) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 181)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 200)\n  (:start . 189) (:id . 74))\n ((:tag . "NNS") (:stem . "locus") (:form . "loci") (:end . 205)\n  (:start . 201) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x895.4.1) (:span 98 101)))\n (:nscopes ((:id . :x895.4.1) (:span 98 205)))\n (:identifiers (:sid . :s895.4) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008356@unknown@formal@none@1@S@Immunoelectron microscopy demonstrated the presence of intensely labelled structures likely to represent the GATA-1 foci seen by immunofluorescence.@(((:tag . "NNP") (:stem . "Immunoelectron") (:form . "Immunoelectron")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 51)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "RB") (:stem . "intensely") (:form . "intensely") (:end . 64)\n  (:start . 55) (:id . 48))\n ((:tag . "VBN") (:stem . "label") (:form . "labelled") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 84)\n  (:start . 74) (:id . 50))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 91)\n  (:start . 85) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 104)\n  (:start . 95) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 115)\n  (:start . 109) (:id . 55))\n ((:tag . "NNS") (:stem . "focus") (:form . "foci") (:end . 120)\n  (:start . 116) (:id . 56))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 125) (:start . 121)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 147) (:start . 129) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x895.5.1) (:span 85 91)))\n (:hscopes ((:id . :x895.5.1) (:span 85 147)))\n (:identifiers (:sid . :s895.5) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008357@unknown@formal@none@1@S@The GATA-1 nuclear bodies differed from previously described nuclear structures and there was no co-localization with nuclear antigens involved in RNA processing or other ubiquitous (Spl, c-Jun and TBP) or haemopoietic (NF-E2) transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 25) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "co-localization") (:form . "co-localization")\n  (:end . 112) (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 181)\n  (:start . 171) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Spl") (:form . "Spl") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 193)\n  (:start . 188) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "haemopoietic") (:form . "haemopoietic") (:end . 218)\n  (:start . 206) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 226) (:start . 225)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 240) (:start . 227) (:id . 79))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 248)\n  (:start . 241) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x895.6.1) (:span 94 96)))\n (:nscopes ((:id . :x895.6.1) (:span 94 248)))\n (:identifiers (:sid . :s895.6) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008358@unknown@formal@none@1@S@Interestingly, GATA-2 and GATA-3 proteins also localized to the same nuclear bodies in cell lines co-expressing GATA-1 and -2 or GATA-1 and -3 gene products.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 83) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "co-expresse") (:form . "co-expressing")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-2") (:form . "-2") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-3") (:form . "-3") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s895.7) (:did . :|8617207|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008360@unknown@formal@none@1@S@Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells.@(((:tag . "NN") (:stem . "modulation") (:form . "Modulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "oppose") (:form . "opposing") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 124)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s896.1) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008361@unknown@formal@none@1@S@A proportion of HIV-infected individuals experience episodes of localized or systemic bacterial infections caused by Gram-negative bacteria.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "VBP") (:stem . "experience") (:form . "experience") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "episode") (:form . "episodes") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 95)\n  (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 113)\n  (:start . 107) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "gram-negative") (:form . "Gram-negative")\n  (:end . 130) (:start . 117) (:id . 57))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 139)\n  (:start . 131) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s896.2) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008362@unknown@formal@none@1@S@Many of the clinical side effects of these infections are associated with the production of proinflammatory cytokines, which are induced primarily by LPS, a constituent of the bacterial cell wall of Gram-negative bacteria.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 107) (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "constituent") (:form . "constituent") (:end . 168)\n  (:start . 157) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 185)\n  (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 195) (:start . 191)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "gram-negative") (:form . "Gram-negative")\n  (:end . 212) (:start . 199) (:id . 75))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 221)\n  (:start . 213) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s896.3) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008363@unknown@formal@none@1@S@The present study examines the mechanisms involved in LPS-mediated induction of HIV expression in U1 cells, a promonocytic cell line chronically infected with HIV.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "examine") (:form . "examines") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 144)\n  (:start . 133) (:id . 63))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s896.4) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008364@unknown@formal@none@1@S@Stimulation of U1 cells by LPS alone induced minimal levels of HIV expression, which was significantly enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF).@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 137) (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 156) (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 171)\n  (:start . 165) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s896.5) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008365@unknown@formal@none@1@S@Costimulation of U1 cells with LPS plus GM-CSF resulted in the accumulation of steady-state levels of HIV RNA; however, only a weak induction of HIV long terminal repeat-driven transcription, which was not associated with the activation of the cellular transcription factor nuclear factor-kappa B, was noted.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "plus") (:form . 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",") (:stem . ",") (:form . ",") (:end . 297) (:start . 296)\n  (:id . 89))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 301) (:start . 298)\n  (:id . 90))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 307)\n  (:start . 302) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 308) (:start . 307)\n  (:id . 92)))@@@1@51@((:ncues ((:id . :x896.6.1) (:span 202 205)))\n (:nscopes ((:id . :x896.6.1) (:span 192 296)))\n (:identifiers (:sid . :s896.6) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008366@unknown@formal@none@1@S@Costimulation of cells with LPS plus GM-CSF induced the production of proinflammatory cytokines, IL-8, IL-1 beta and IL-6, but not TNF-alpha.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 85) (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x896.7.1) (:span 127 130)))\n (:nscopes ((:id . :x896.7.1) (:span 127 140)))\n (:identifiers (:sid . :s896.7) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008367@unknown@formal@none@1@S@IL-1 receptor antagonist (ra) inhibited LPS enhancement of HIV expression in GM-CSF-stimulated cells, suggesting that endogenous IL-1 was involved in LPS-mediated viral production.@(((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ra") (:form . "ra") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "gm-csf-stimulated") (:form . "GM-CSF-stimulated")\n  (:end . 94) (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 146)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 162)\n  (:start . 150) (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 179)\n  (:start . 169) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x896.8.1) (:span 102 112)))\n (:hscopes ((:id . :x896.8.1) (:span 102 179)))\n (:identifiers (:sid . :s896.8) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008368@unknown@formal@none@1@S@In this regard, anti-inflammatory cytokines inhibited LPS plus GM-CSF-stimulated HIV expression, and this effect closely correlated with inhibition of IL-1 beta release and, in particular, with up-regulation of endogenous IL-1ra production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 33) (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gm-csf-stimulated") (:form . "GM-CSF-stimulated")\n  (:end . 80) (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 131)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 168)\n  (:start . 161) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 207) (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 221)\n  (:start . 211) (:id . 74))\n ((:tag . "NNP") (:stem . "IL-1ra") (:form . "IL-1ra") (:end . 228)\n  (:start . 222) (:id . 75))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 239)\n  (:start . 229) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s896.9) (:did . :|8617979|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008370@unknown@formal@none@1@S@Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s897.1) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008371@unknown@formal@none@1@S@Convergence of costimulatory signals and differences from transformed T cells.@(((:tag . "NNP") (:stem . "Convergence") (:form . "Convergence") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 52)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 69)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s897.2) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008372@unknown@formal@none@1@S@To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "optimize") (:form . "optimized") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 116)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s897.3) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008373@unknown@formal@none@1@S@Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.@(((:tag . "NN") (:stem . "interleukin-2") (:form . "Interleukin-2")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promoter-reporter") (:form . "promoter-reporter")\n  (:end . 38) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "behavior") (:form . "behavior") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "VBZ") (:stem . "parallel") (:form . "parallels") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s897.4) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008374@unknown@formal@none@1@S@As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mutagenize") (:form . "mutagenized") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 78) (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "NF-") (:stem . "nf-") (:form . "NF-") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s897.5) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008375@unknown@formal@none@1@S@Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 48) (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 125)\n  (:start . 115) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "b7-positive") (:form . "B7-positive") (:end . 140)\n  (:start . 129) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "b7-negative") (:form . "B7-negative") (:end . 165)\n  (:start . 154) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 195)\n  (:start . 190) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 75))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 200) (:start . 197)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 209)\n  (:start . 201) (:id . 77))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 217)\n  (:start . 210) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 226) (:start . 222)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 239)\n  (:start . 227) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s897.6) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008376@unknown@formal@none@1@S@Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s897.7) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008377@unknown@formal@none@1@S@We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 138) (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 146)\n  (:start . 139) (:id . 62))\n ((:tag . "VBP") (:stem . "converge") (:form . "converge") (:end . 155)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 167) (:start . 163)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cis-element") (:form . "cis-elements") (:end . 180)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 201)\n  (:start . 193) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s897.8) (:did . :|8621390|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008378@unknown@formal@none@1@S@A hydrophobic domain of Ca2+-modulating cyclophilin ligand modulates calcium influx signaling in T lymphocytes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hydrophobic") (:form . "hydrophobic") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ca2+-modulating") (:form . "Ca2+-modulating")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 51)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 58)\n  (:start . 52) (:id . 48))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 68)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 83)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 110)\n  (:start . 99) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s898.1) (:did . :|8621480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008380@unknown@formal@none@1@S@As reported here, structure-function analysis of the CAML gene in Jurkat T cells indicates that two of CAML's putative membrane-spanning domains are necessary and sufficient for the modulation of intracellular calcium.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "structure-function") (:form . "structure-function")\n  (:end . 36) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "JJ") (:stem . "membrane-spanning") (:form . "membrane-spanning")\n  (:end . 136) (:start . 119) (:id . 63))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 173)\n  (:start . 163) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 192)\n  (:start . 182) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 209) (:start . 196) (:id . 73))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 217)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x898.3.1) (:span 110 118))\n  ((:id . :x898.3.2) (:span 81 95)))\n (:hscopes ((:id . :x898.3.1) (:span 110 144))\n  ((:id . :x898.3.2) (:span 81 217)))\n (:identifiers (:sid . :s898.3) (:did . :|8621480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008381@unknown@formal@none@1@S@We propose that the hydrophobic C-terminal tail of CAML forms its effector domain, thus implicating the N-terminal hydrophilic domain in a regulatory role.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "hydrophobic") (:form . "hydrophobic") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "hydrophilic") (:form . "hydrophilic") (:end . 126)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x898.4.1) (:span 3 10)))\n (:hscopes ((:id . :x898.4.1) (:span 3 154)))\n (:identifiers (:sid . :s898.4) (:did . :|8621480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008382@unknown@formal@none@1@S@These findings define a novel protein motif that functions in intracellular calcium signaling.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "define") (:form . "define") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 75) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s898.5) (:did . :|8621480|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008383@unknown@formal@none@1@S@Interactions of a transcriptional activator in the env gene of the mouse mammary tumor virus with activation-dependent, T cell-specific transacting factors.@(((:tag . "NNS") (:stem . "interaction") (:form . "Interactions") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "env") (:form . "env") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 118) (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 135) (:start . 122) (:id . 61))\n ((:tag . "VBG") (:stem . "transact") (:form . "transacting") (:end . 147)\n  (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 155)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s899.1) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008384@unknown@formal@none@1@S@The mouse mammary tumor virus env gene contains a transcriptional activator (META) that can control transcription of the adjacent long terminal repeat region.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "env") (:form . "env") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 65) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "META") (:form . "META") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 113) (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s899.2) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008385@unknown@formal@none@1@S@Transcriptional control by META parallels that of several lymphokine genes, being specific to T cells, dependent on their activation, and inhibited by the immunosuppressive drug cyclosporine (CsA).@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "META") (:form . "META") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "parallel") (:form . "parallels") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 172) (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 190)\n  (:start . 178) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s899.3) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008386@unknown@formal@none@1@S@DNase I footprinting indicated that nuclear factors from activated T lymphocytes bound a promoter-proximal site, META(P), and a promoter-distal site, META(D+), within the 400-base pair META region.@(((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "promoter-proximal") (:form . "promoter-proximal")\n  (:end . 106) (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "CD") (:stem . "META(P)") (:form . "META(P)") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "promoter-distal") (:form . "promoter-distal")\n  (:end . 143) (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "META(D+)") (:form . "META(D+)") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 166)\n  (:start . 160) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "400-base") (:form . "400-base") (:end . 179)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "META") (:form . "META") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 196)\n  (:start . 190) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x899.4.1) (:span 21 35)))\n (:hscopes ((:id . :x899.4.1) (:span 21 196)))\n (:identifiers (:sid . :s899.4) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008387@unknown@formal@none@1@S@Nuclear factors from unstimulated, but not from activated cells, bound a site, META(D-), adjacent to META(D+).@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "META(D-)") (:form . "META(D-)") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "CD") (:stem . "META(D+)") (:form . "META(D+)") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x899.5.1) (:span 39 42)))\n (:nscopes ((:id . :x899.5.1) (:span 39 63)))\n (:identifiers (:sid . :s899.5) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008388@unknown@formal@none@1@S@META(D+) directed transcription of a linked luciferase gene, and gel shift analysis revealed binding of inducible, CsA-sensitive T cell factors, in parallel with transfection results.@(((:tag . "NNP") (:stem . "META(D+)") (:form . "META(D+)") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "direct") (:form . "directed") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 43) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "csa-sensitive") (:form . "CsA-sensitive")\n  (:end . 128) (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 174)\n  (:start . 162) (:id . 68))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 182)\n  (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s899.6) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008390@unknown@formal@none@1@S@The SV40 core sequence competed for META(D+) binding factors, but META(D+) failed to compete for the complexes obtained with the SV40 probe.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "compete") (:form . "competed") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "META(D+)") (:form . "META(D+)") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "META(D+)") (:form . "META(D+)") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 81) (:start . 75)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x899.8.1) (:span 75 81)))\n (:nscopes ((:id . :x899.8.1) (:span 75 139)))\n (:identifiers (:sid . :s899.8) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008391@unknown@formal@none@1@S@Our results, taken together, indicate that META(D+) is a novel transcriptional enhancer element that is similar in its cell-type specificity, activation dependence, and CsA sensitivity to the NFAT element.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "META(D+)") (:form . "META(D+)") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 78) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 140)\n  (:start . 129) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 152)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 184)\n  (:start . 173) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 196) (:start . 192)\n  (:id . 73))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 204)\n  (:start . 197) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x899.9.1) (:span 29 42)))\n (:hscopes ((:id . :x899.9.1) (:span 29 204)))\n (:identifiers (:sid . :s899.9) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008392@unknown@formal@none@1@S@It may be relevant to the role of MMTV in expression of Mls antigens or the induction of T cell lymphomas.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MMTV") (:form . "MMTV") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Ml") (:form . "Mls") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 85)\n  (:start . 76) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 105)\n  (:start . 96) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x899.10.1) (:span 69 71)) ((:id . :x899.10.2) (:span 3 6)))\n (:hscopes ((:id . :x899.10.1) (:span 22 105))\n  ((:id . :x899.10.2) (:span 3 105)))\n (:identifiers (:sid . :s899.10) (:did . :|8621538|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008393@unknown@formal@none@1@S@Monocytic cell type-specific transcriptional induction of collagenase.@(((:tag . "JJ") (:stem . "monocytic") (:form . "Monocytic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 44) (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 54)\n  (:start . 45) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 47))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 69)\n  (:start . 58) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s900.1) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008394@unknown@formal@none@1@S@Interstitial collagenase (MMP-1), a metalloproteinase produced by resident and inflammatory cells during connective tissue turnover, cleaves type I collagen fibrils.@(((:tag . "JJ") (:stem . "interstitial") (:form . "Interstitial") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mmp-1") (:form . "MMP-1") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "metalloproteinase") (:form . "metalloproteinase")\n  (:end . 53) (:start . 36) (:id . 49))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "resident") (:form . "resident") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 91)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "JJ") (:stem . "connective") (:form . "connective") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "cleave") (:form . "cleaves") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "collagen") (:form . "collagen") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "NNS") (:stem . "fibril") (:form . "fibrils") (:end . 164)\n  (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s900.2) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008395@unknown@formal@none@1@S@This catalytic event is rate limiting in remodeling of tissues rich in fibrillar collagen such as the skin and lungs.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "remodeling") (:form . "remodeling") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "rich") (:form . "rich") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fibrillar") (:form . "fibrillar") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "collagen") (:form . "collagen") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lung") (:form . "lungs") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s900.3) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008396@unknown@formal@none@1@S@The regulation of collagenase expression is cell-type specific; bacterial LPS and zymosan, a yeast cell wall derivative, are potent inducers of collagenase expression in macrophages, but do not alter fibroblast collagenase expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-type") (:form . "cell-type") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "zymosan") (:form . "zymosan") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 166)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 181)\n  (:start . 170) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 193) (:start . 190)\n  (:id . 73))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 199)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 210)\n  (:start . 200) (:id . 75))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 222)\n  (:start . 211) (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 233)\n  (:start . 223) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x900.4.1) (:span 190 193)))\n (:nscopes ((:id . :x900.4.1) (:span 190 233)))\n (:identifiers (:sid . :s900.4) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008397@unknown@formal@none@1@S@Since promoter elements controlling collagenase transcription in monocytic cells have not been previously defined, we sought to delineate responsive cis-acting elements of the collagenase promoter in transiently transfected human (U937) and murine (J774) monocytic cell lines.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 74)\n  (:start . 65) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 85) (:start . 81)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 113)\n  (:start . 106) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 137)\n  (:start . 128) (:id . 60))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 148)\n  (:start . 138) (:id . 61))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 168)\n  (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 65))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 187)\n  (:start . 176) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 196)\n  (:start . 188) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 68))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 211)\n  (:start . 200) (:id . 69))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 223)\n  (:start . 212) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 229)\n  (:start . 224) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 72))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 235) (:start . 231)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 236) (:start . 235)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 247)\n  (:start . 241) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 249) (:start . 248)\n  (:id . 77))\n ((:tag . "NN") (:stem . "j774") (:form . "J774") (:end . 253) (:start . 249)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 254) (:start . 253)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 264)\n  (:start . 255) (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 269) (:start . 265)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 275)\n  (:start . 270) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x900.5.1) (:span 86 89)))\n (:nscopes ((:id . :x900.5.1) (:span 6 113)))\n (:identifiers (:sid . :s900.5) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008398@unknown@formal@none@1@S@Deletion constructs containing as little as 72 bp of 5' -flanking sequence of the collagenase promoter were sufficient for LPS- or zymosan-mediated transcriptional induction, whereas phorbol inducibility exhibited an absolute requirement for upstream elements including the polyoma enhancer A-binding protein-3 site (-83 to -91) and TTCA sequence (-102 to -105) in both monocytic cells and fibroblasts.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . 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5008400@unknown@formal@none@1@S@Nuclear extracts from LPS- and zymosan-treated cells showed strong AP-1 activity by gel-shift analysis, and supershift analysis showed the AP-1 complexes contained specific members of both the jun and fos gene families.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lps-") (:form . "LPS-") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "zymosan-treated") (:form . "zymosan-treated")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 59) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 163)\n  (:start . 154) (:id . 64))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 172)\n  (:start . 164) (:id . 65))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 180)\n  (:start . 173) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 196) (:start . 193)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 204) (:start . 201)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 209) (:start . 205)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 218)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s900.8) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008401@unknown@formal@none@1@S@These data indicate that, in contrast to most LPS effects, AP-1, but not nuclear factor-kappaB, mediates LPS induction of collagenase transcription in macrophagelike cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 80)\n  (:start . 73) (:id . 58))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 94) (:start . 81) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 118)\n  (:start . 109) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 133)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 147) (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "macrophagelike") (:form . "macrophagelike")\n  (:end . 165) (:start . 151) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x900.9.2) (:span 11 24)))\n (:ncues ((:id . :x900.9.1) (:span 69 72)))\n (:hscopes ((:id . :x900.9.2) (:span 11 171)))\n (:nscopes ((:id . :x900.9.1) (:span 69 94)))\n (:identifiers (:sid . :s900.9) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008402@unknown@formal@none@1@S@Furthermore, as compared to regulation by phorbol ester, collagenase induction in monocytic cells by cell wall derivatives of bacteria or yeast is largely independent of upstream promoter sequences.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "collagenase") (:form . "collagenase") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 166)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 197)\n  (:start . 188) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s900.10) (:did . :|8621773|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008403@unknown@formal@none@1@S@Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B.@(((:tag . "JJ") (:stem . "inhibitory") (:form . "Inhibitory") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "E3330") (:form . "E3330") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "quinone") (:form . "quinone") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s901.1) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008404@unknown@formal@none@1@S@(2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid (E3330), is a novel agent with hepatoprotective activity.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP")\n  (:stem . "2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2-")\n  (:form . "2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2-")\n  (:end . 63) (:start . 1) (:id . 43))\n ((:tag . "JJ") (:stem . "propenoic") (:form . "propenoic") (:end . 73)\n  (:start . 64) (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 78) (:start . 74)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "E3330") (:form . "E3330") (:end . 85) (:start . 80)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 98) (:start . 93)\n  (:id . 52))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 104) (:start . 99)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hepatoprotective") (:form . "hepatoprotective")\n  (:end . 126) (:start . 110) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s901.2) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008405@unknown@formal@none@1@S@We report the effect of E3330 on transcriptional activation of tumor necrosis factor (TNF)-alpha gene and on nuclear factor (NF)-kappa B activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "e3330") (:form . "E3330") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 48) (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF)-alpha") (:form . "TNF)-alpha") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s901.3) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008406@unknown@formal@none@1@S@Nuclear run-on experiments showed that E3330 decreases transcriptional activation of TNF-alpha gene induced by lipopolysaccharide (LPS) stimulation in human peripheral monocytes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 33) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "e3330") (:form . "E3330") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 70) (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 99) (:start . 95)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 107)\n  (:start . 100) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 129) (:start . 111) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 134) (:start . 131)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 147)\n  (:start . 136) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 156)\n  (:start . 151) (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 167)\n  (:start . 157) (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 177)\n  (:start . 168) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s901.4) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008407@unknown@formal@none@1@S@To investigate the inhibitory mechanisms, we constructed a secreted-type placental alkaline phosphatase (PLAP) reporter gene whose transcription is controlled by a 1.4-kb human TNF-alpha promoter.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "construct") (:form . "constructed") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "secreted-type") (:form . "secreted-type")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "placental") (:form . "placental") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "alkaline") (:form . "alkaline") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PLAP") (:form . "PLAP") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 158)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "1.4-kb") (:form . "1.4-kb") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 186)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 195)\n  (:start . 187) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s901.5) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008408@unknown@formal@none@1@S@A stable transformant of the PLAP reporter gene derived from human monocytic cell line showed very little activity on the promoter before stimulation, whereas LPS stimulation led to a dramatic increase in PLAP activity.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transformant") (:form . "transformant") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PLAP") (:form . "PLAP") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 93) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 149)\n  (:start . 138) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 174)\n  (:start . 163) (:id . 68))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 192)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 201)\n  (:start . 193) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PLAP") (:form . "PLAP") (:end . 209) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s901.6) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008410@unknown@formal@none@1@S@There are four putative NF-kappa B binding sites (kappa B-1, kappa B-2, kappa B-3, kappa B-4) in human TNF-alpha promoter.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-1") (:form . "B-1") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "b-2") (:form . "B-2") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B-3") (:form . "B-3") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 88) (:start . 83)\n  (:id . 60))\n ((:tag . "NN") (:stem . "b-4") (:form . "B-4") (:end . 92) (:start . 89)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 112)\n  (:start . 103) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 121)\n  (:start . 113) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s901.8) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008411@unknown@formal@none@1@S@By using mutated promoter-PLAP plasmids, we established that these NF-kappa B sites were necessary for induction of TNF-alpha transcription on stimulation with LPS.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "promoter-plap") (:form . "promoter-PLAP")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 154)\n  (:start . 143) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s901.9) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008412@unknown@formal@none@1@S@A gel retardation experiment with synthetic double-stranded oligonucleotides showed that activated NF-kappa B consisting of p50/p65 heterodimer bound to all four putative NF-kappa B DNA probes, suggesting that all four putative NF-kappa B recognition sites play an important role in inducible TNF-alpha expression.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "retardation") (:form . "retardation") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 59) (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 76) (:start . 60) (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 83) (:start . 77)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 98)\n  (:start . 89) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 120)\n  (:start . 110) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 131)\n  (:start . 124) (:id . 57))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 143)\n  (:start . 132) (:id . 58))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 149)\n  (:start . 144) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 156) (:start . 153)\n  (:id . 61))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 161) (:start . 157)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 170)\n  (:start . 162) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 179)\n  (:start . 171) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 181) (:start . 180)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 185) (:start . 182)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 192)\n  (:start . 186) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 204)\n  (:start . 194) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 209) (:start . 205)\n  (:id . 70))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 213) (:start . 210)\n  (:id . 71))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 218) (:start . 214)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 227)\n  (:start . 219) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 236)\n  (:start . 228) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 238) (:start . 237)\n  (:id . 75))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 250)\n  (:start . 239) (:id . 76))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 256)\n  (:start . 251) (:id . 77))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 261) (:start . 257)\n  (:id . 78))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 264) (:start . 262)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 274)\n  (:start . 265) (:id . 80))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 279) (:start . 275)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 282) (:start . 280)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 292)\n  (:start . 283) (:id . 83))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 302)\n  (:start . 293) (:id . 84))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 313)\n  (:start . 303) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 314) (:start . 313)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x901.10.1) (:span 194 204)))\n (:hscopes ((:id . :x901.10.1) (:span 194 313)))\n (:identifiers (:sid . :s901.10) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008413@unknown@formal@none@1@S@E3330 decreased activated NF-kappa B in nuclei, suggesting that E3330 inhibits NF-kappa B activation and/or translocation of the nuclei.@(((:tag . "NNP") (:stem . "E3330") (:form . "E3330") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "e3330") (:form . "E3330") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 121) (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x901.11.1) (:span 48 58)))\n (:hscopes ((:id . :x901.11.1) (:span 48 135)))\n (:identifiers (:sid . :s901.11) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008414@unknown@formal@none@1@S@Western blotting analysis with anti-I kappa B-alpha antibody indicated that E3330 inhibited degradation of I kappa B-alpha, which is an inhibitory protein of NF-kappa B, in LPS-stimulated monocytes.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti-i") (:form . "anti-I") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "E3330") (:form . "E3330") (:end . 81) (:start . 76)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 187) (:start . 173) (:id . 70))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 197)\n  (:start . 188) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x901.12.1) (:span 61 75)))\n (:hscopes ((:id . :x901.12.1) (:span 61 197)))\n (:identifiers (:sid . :s901.12) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008415@unknown@formal@none@1@S@E3330 may suppress the production of active oxygen species serving as common messengers to activate NF-kappa B.@(((:tag . "NNP") (:stem . "E3330") (:form . "E3330") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "VBG") (:stem . "serve") (:form . "serving") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x901.13.1) (:span 6 9)))\n (:hscopes ((:id . :x901.13.1) (:span 6 110)))\n (:identifiers (:sid . :s901.13) (:did . :|8622636|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008416@unknown@formal@none@1@S@The role of p16 in the E2F-dependent thymidine kinase regulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "e2f-dependent") (:form . "E2F-dependent")\n  (:end . 36) (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s902.1) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008417@unknown@formal@none@1@S@The role of alterations of the MTS1 tumor suppressor gene on chromosome 9p21, which encodes p16, the inhibitor of cyclin-dependent-kinase-4 and 6, in tumorigenesis is not yet clear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mts1") (:form . "MTS1") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "9p21") (:form . "9p21") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cyclin-dependent-kinase-4")\n  (:form . "cyclin-dependent-kinase-4") (:end . 139) (:start . 114)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tumorigenesis") (:form . "tumorigenesis")\n  (:end . 163) (:start . 150) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 180)\n  (:start . 175) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x902.2.1) (:span 167 170 175 180)))\n (:hscopes ((:id . :x902.2.1) (:span 0 180)))\n (:identifiers (:sid . :s902.2) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008418@unknown@formal@none@1@S@Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F, which subsequently promotes the expression of S phase regulated genes, such as thymidine kinase.@(((:tag . "NN") (:stem . "phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 37) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cyclin-dependent") (:form . "cyclin-dependent")\n  (:end . 65) (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 75) (:start . 74)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 106)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 59))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 160)\n  (:start . 148) (:id . 63))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 169)\n  (:start . 161) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 184)\n  (:start . 174) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 189) (:start . 188)\n  (:id . 68))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 195)\n  (:start . 190) (:id . 69))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 205)\n  (:start . 196) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 211)\n  (:start . 206) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 217) (:start . 213)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 220) (:start . 218)\n  (:id . 74))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 230)\n  (:start . 221) (:id . 75))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 237)\n  (:start . 231) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s902.3) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008420@unknown@formal@none@1@S@We investigated the regulation of thymidine kinase in phytohemagglutinin-stimulated normal human lymphocytes and in the p16-negative human acute lymphoblastic leukemia cell lines, MOLT-4 and CEM.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "phytohemagglutinin-stimulated")\n  (:form . "phytohemagglutinin-stimulated") (:end . 83) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 90)\n  (:start . 84) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 96) (:start . 91)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 108)\n  (:start . 97) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "p16-negative") (:form . "p16-negative") (:end . 132)\n  (:start . 120) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 58))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 144)\n  (:start . 139) (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 158) (:start . 145) (:id . 60))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 167)\n  (:start . 159) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 178)\n  (:start . 173) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 64))\n ((:tag . "NN") (:stem . "molt-4") (:form . "MOLT-4") (:end . 186)\n  (:start . 180) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 194) (:start . 191)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s902.5) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008421@unknown@formal@none@1@S@Compared to normal lymphocytes, MOLT-4 and CEM cells exhibited an altered cell cycle regulation of thymidine kinase, a much higher intracellular activity of this enzyme, and higher thymidine kinase mRNA expression.@(((:tag . "VBN") (:stem . "compare") (:form . "Compared") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "molt-4") (:form . "MOLT-4") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 168)\n  (:start . 162) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 70))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 180)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 190)\n  (:start . 181) (:id . 72))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 197)\n  (:start . 191) (:id . 73))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 202) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 213)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s902.6) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008422@unknown@formal@none@1@S@Transient expression of p16 in normal human lymphocytes caused arrest in G1, but was without effect on the cell growth of MOLT-4 and CEM cells, although all of them express functional retinoblastoma protein.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "G1") (:form . "G1") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "molt-4") (:form . "MOLT-4") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 152)\n  (:start . 144) (:id . 69))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 172)\n  (:start . 165) (:id . 73))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 183)\n  (:start . 173) (:id . 74))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 198) (:start . 184) (:id . 75))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 206)\n  (:start . 199) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x902.7.1) (:span 85 92)))\n (:nscopes ((:id . :x902.7.1) (:span 85 142)))\n (:identifiers (:sid . :s902.7) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008423@unknown@formal@none@1@S@Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase, paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 69) (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "reestablish") (:form . "reestablished") (:end . 90)\n  (:start . 77) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "parallel") (:form . "paralleled") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "underphosphorylated")\n  (:form . "underphosphorylated") (:end . 186) (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 209) (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 217)\n  (:start . 210) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 73))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 230)\n  (:start . 222) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 238) (:start . 234)\n  (:id . 76))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 242) (:start . 239)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 248)\n  (:start . 243) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 251) (:start . 249)\n  (:id . 79))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 255) (:start . 252)\n  (:id . 80))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 261)\n  (:start . 256) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 268) (:start . 265)\n  (:id . 83))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 278)\n  (:start . 269) (:id . 84))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 285)\n  (:start . 279) (:id . 85))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 294)\n  (:start . 286) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s902.8) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008424@unknown@formal@none@1@S@We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p16") (:form . "p16") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "retinoblastoma") (:form . "retinoblastoma")\n  (:end . 150) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s902.9) (:did . :|8622883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008425@unknown@formal@none@1@S@Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.@(((:tag . "JJ") (:stem . "rel-deficient") (:form . "Rel-deficient")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 95) (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 114) (:start . 96) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 121)\n  (:start . 115) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s903.1) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008426@unknown@formal@none@1@S@The c-rel protooncogene encodes a subunit of the NF-kappa B-like family of transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-rel") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "b-like") (:form . "B-like") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s903.2) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008427@unknown@formal@none@1@S@Mice lacking Rel are defective in mitogenic activation of B and T lymphocytes and display impaired humoral immunity.@(((:tag . "NNS") (:stem . "mouse") (:form . "Mice") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 12) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "humoral") (:form . "humoral") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x903.3.1) (:span 5 12)))\n (:nscopes ((:id . :x903.3.1) (:span 5 16)))\n (:identifiers (:sid . :s903.3) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008428@unknown@formal@none@1@S@In an attempt to identify changes in gene expression that accompany the T-cell stimulation defects associated with the loss of Rel, we have examined the expression of cell surface activation markers and cytokine production in mitogen-stimulated Rel-/- T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "attempt") (:form . "attempt") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "accompany") (:form . "accompany") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 179)\n  (:start . 172) (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 190)\n  (:start . 180) (:id . 72))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 198)\n  (:start . 191) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 211)\n  (:start . 203) (:id . 75))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 222)\n  (:start . 212) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 225) (:start . 223)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "mitogen-stimulated") (:form . "mitogen-stimulated")\n  (:end . 244) (:start . 226) (:id . 78))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 251)\n  (:start . 245) (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 253) (:start . 252)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 259)\n  (:start . 254) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s903.4) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008430@unknown@formal@none@1@S@In Rel-/- splenic T cell cultures stimulated with phorbol 12-myristate 13-acetate and ionomycin, the levels of IL-3, IL-5, granulocyte- macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor alpha (TNF-alpha), and gamma interferon (IFN-gamma) were only 2- to 3-fold lower compared with normal T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . 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"GM-CSF") (:end . 180)\n  (:start . 174) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 188)\n  (:start . 183) (:id . 71))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 197)\n  (:start . 189) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 204)\n  (:start . 198) (:id . 73))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 210)\n  (:start . 205) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 212) (:start . 211)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 221)\n  (:start . 212) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 78))\n ((:tag . 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"3-fold") (:end . 279)\n  (:start . 273) (:id . 89))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 285) (:start . 280)\n  (:id . 90))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 294)\n  (:start . 286) (:id . 91))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 299) (:start . 295)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 306)\n  (:start . 300) (:id . 93))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 308) (:start . 307)\n  (:id . 94))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 314)\n  (:start . 309) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 315) (:start . 314)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s903.6) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008431@unknown@formal@none@1@S@In contrast, anti-CD3 and anti-CD28 stimulated Rel-/- T cells, which fail to proliferate, make little or no detectable cytokines.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VB") (:stem . "proliferate") (:form . "proliferate") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "VB") (:stem . "make") (:form . "make") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 118)\n  (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x903.7.1) (:span 105 107))\n  ((:id . :x903.7.2) (:span 69 73)))\n (:nscopes ((:id . :x903.7.1) (:span 105 128))\n  ((:id . :x903.7.2) (:span 69 88)))\n (:identifiers (:sid . :s903.7) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008432@unknown@formal@none@1@S@Exogenous IL-2, which restitutes the proliferative response of the anti-CD3- and anti-CD28-treated Rel-/- T cells, restores production of IL-5, TNF-alpha, and IFN-gamma, but not IL-3 and GM-CSF expression to approximately normal levels.@(((:tag . "JJ") (:stem . "exogenous") (:form . "Exogenous") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "restitute") (:form . "restitutes") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti-cd3-") (:form . "anti-CD3-") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-cd28-treated") (:form . "anti-CD28-treated")\n  (:end . 98) (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "restore") (:form . "restores") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 177) (:start . 174)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 182) (:start . 178)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 204)\n  (:start . 194) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 221) (:start . 208) (:id . 76))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 228)\n  (:start . 222) (:id . 77))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 235)\n  (:start . 229) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x903.8.1) (:span 174 177)))\n (:nscopes ((:id . :x903.8.1) (:span 174 204)))\n (:identifiers (:sid . :s903.8) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008433@unknown@formal@none@1@S@In contrast to mitogen-activated Rel-/- T cells, lipopolysaccharide-stimulated Rel-/- macrophages produce higher than normal levels of GM-CSF.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 32) (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 78) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rel-/-") (:form . "Rel-/-") (:end . 85)\n  (:start . 79) (:id . 51))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 97)\n  (:start . 86) (:id . 52))\n ((:tag . "VBP") (:stem . "produce") (:form . "produce") (:end . 105)\n  (:start . 98) (:id . 53))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 112)\n  (:start . 106) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 117) (:start . 113)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 124)\n  (:start . 118) (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 131)\n  (:start . 125) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 141)\n  (:start . 135) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s903.9) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008434@unknown@formal@none@1@S@These findings establish that Rel can function as an activator or repressor of gene expression and is required by T lymphocytes for production of IL-3 and GM-CSF.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 127)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-3") (:form . "IL-3") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s903.10) (:did . :|8622948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008435@unknown@formal@none@1@S@Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lymphotropic") (:form . "lymphotropic") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "virus-i") (:form . "virus-I") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "beta-galactoside-binding")\n  (:form . "beta-galactoside-binding") (:end . 112) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 119)\n  (:start . 113) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 131)\n  (:start . 121) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s904.1) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008436@unknown@formal@none@1@S@Animal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates.@(((:tag . "NNP") (:stem . "Animal") (:form . "Animal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lectin") (:form . "lectins") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 82)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "glycoconjugate") (:form . "glycoconjugates")\n  (:end . 113) (:start . 98) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s904.2) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008437@unknown@formal@none@1@S@Galectin-3 is a beta-galactoside-binding lectin previously designated as epsilon BP (IgE-binding protein), CBP35, Mac-2, L-29, and L-34, and its expression has been associated with various physiological and pathological processes, including cell growth, tumor transformation, and metastasis.@(((:tag . "NN") (:stem . "galectin-3") (:form . "Galectin-3") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "beta-galactoside-binding")\n  (:form . "beta-galactoside-binding") (:end . 40) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "lectin") (:form . "lectin") (:end . 47)\n  (:start . 41) (:id . 46))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 58)\n  (:start . 48) (:id . 47))\n ((:tag . "VBN") (:stem . "designate") (:form . 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5008438@unknown@formal@none@1@S@Galectin-3 is widely distributed in various tissues and cell types and is expressed in many leukocytes, with the notable exception of B and T lymphocytes.@(((:tag . "NN") (:stem . "galectin-3") (:form . "Galectin-3") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "notable") (:form . "notable") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 153)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x904.4.1) (:span 104 133)))\n (:nscopes ((:id . :x904.4.1) (:span 104 153)))\n (:identifiers (:sid . :s904.4) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008440@unknown@formal@none@1@S@In addition, the galectin-3 level was markedly increased in human thymocytes after infection with HTLV-I as compared with uninfected thymocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s904.6) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008441@unknown@formal@none@1@S@The up-regulation of galectin-3 expression appeared to correlate well with HTLV-I gene expression, as undetectable or very low levels of galectin-3 were found in the S1T and ATL-1K cell lines, which are nonproductively infected with HTLV-I.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 114)\n  (:start . 102) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "S1T") (:form . "S1T") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "ATL-1K") (:form . "ATL-1K") (:end . 180)\n  (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 185) (:start . 181)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 191)\n  (:start . 186) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 198)\n  (:start . 193) (:id . 74))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 202) (:start . 199)\n  (:id . 75))\n ((:tag . "RB") (:stem . "nonproductively") (:form . "nonproductively")\n  (:end . 218) (:start . 203) (:id . 76))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 227)\n  (:start . 219) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 232) (:start . 228)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 239)\n  (:start . 233) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x904.7.1) (:span 43 51)))\n (:hscopes ((:id . :x904.7.1) (:span 0 97)))\n (:identifiers (:sid . :s904.7) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008442@unknown@formal@none@1@S@In co-transfection experiments, the galectin-3 promoter was significantly up-regulated by expression vectors encoding the 40-kd Tax protein, a potent transactivator in HTLV-I.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "co-transfection") (:form . "co-transfection")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 86)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 53))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 108)\n  (:start . 101) (:id . 54))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 117)\n  (:start . 109) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "40-kd") (:form . "40-kd") (:end . 127)\n  (:start . 122) (:id . 57))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 149)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 164) (:start . 150) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 174)\n  (:start . 168) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s904.8) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008443@unknown@formal@none@1@S@Analysis of various Tax mutants suggested that galectin-3 promoter induction is dependent on activation of the cyclic-AMP-responsive element binding protein/activation transcription factor family of transcription factors and, to a lesser extent, nuclear factor-kappa B/Rel induction.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 103)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cyclic-amp-responsive")\n  (:form . "cyclic-AMP-responsive") (:end . 132) (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 140)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 148)\n  (:start . 141) (:id . 60))\n ((:tag . "NN") (:stem . "protein/activation") (:form . "protein/activation")\n  (:end . 167) (:start . 149) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 181) (:start . 168) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 188)\n  (:start . 182) (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 195)\n  (:start . 189) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 212) (:start . 199) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 220)\n  (:start . 213) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 228) (:start . 226)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 230) (:start . 229)\n  (:id . 71))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 237)\n  (:start . 231) (:id . 72))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 244)\n  (:start . 238) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 253)\n  (:start . 246) (:id . 75))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 266)\n  (:start . 254) (:id . 76))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 272)\n  (:start . 267) (:id . 77))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 282)\n  (:start . 273) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x904.9.1) (:span 32 41)))\n (:hscopes ((:id . :x904.9.1) (:span 32 282)))\n (:identifiers (:sid . :s904.9) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008444@unknown@formal@none@1@S@Transfection of human promonocytic U-937 cells with an HTLV-I Tax expression vector induced galectin-3 expression in this cell line.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 102)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s904.10) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008445@unknown@formal@none@1@S@Functionally, galectin-3 was shown to activate interleukin-2 production in Jurkat T cells.@(((:tag . "RB") (:stem . "functionally") (:form . "Functionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "galectin-3") (:form . "galectin-3") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s904.11) (:did . :|8623933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008446@unknown@formal@none@1@S@Together, these findings raise the possibility that HTLV-I Tax production induces the transcription and subsequent synthesis and secretion of galectin-3, which in turn may further activate these T cells and contribute to the altered properties of cell growth found in adult T cell leukemia induced by HTLV-I.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "raise") (:form . "raise") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "possibility") (:form . 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5008447@unknown@formal@none@1@S@Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 131) (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 142)\n  (:start . 132) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s905.1) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008448@unknown@formal@none@1@S@Activation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 100) (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s905.2) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008450@unknown@formal@none@1@S@The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD28RE") (:form . "CD28RE") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 127)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 67))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 153)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s905.4) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008451@unknown@formal@none@1@S@The CD28RE sequence reveals similarity to the consensus kappaB binding motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CD28RE") (:form . "CD28RE") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s905.5) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008452@unknown@formal@none@1@S@Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD28RE") (:form . "CD28RE") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 97) (:start . 84) (:id . 56))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mitogenic-activated")\n  (:form . "mitogenic-activated") (:end . 149) (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-MATp35") (:form . "NF-MATp35") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 185)\n  (:start . 178) (:id . 71))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 195)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 200) (:start . 196)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 210)\n  (:start . 205) (:id . 75))\n ((:tag . "NF-") (:stem . "nf-") (:form . "NF-") (:end . 214) (:start . 211)\n  (:id . 76))\n ((:tag . "NN") (:stem . "kappab/rel") (:form . "kappaB/Rel") (:end . 225)\n  (:start . 215) (:id . 77))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 232)\n  (:start . 226) (:id . 78))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 240)\n  (:start . 233) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s905.6) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008453@unknown@formal@none@1@S@Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-MATp35") (:form . "NF-MATp35") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "receive") (:form . "received") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 139)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 157)\n  (:start . 150) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 174)\n  (:start . 163) (:id . 71))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 184)\n  (:start . 175) (:id . 72))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 189) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 199)\n  (:start . 190) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s905.7) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008454@unknown@formal@none@1@S@Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35.@(((:tag . "JJ") (:stem . "nonmitogenic") (:form . "Nonmitogenic") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-MATp35") (:form . "NF-MATp35") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x905.8.1) (:span 36 39)))\n (:nscopes ((:id . :x905.8.1) (:span 36 73)))\n (:identifiers (:sid . :s905.8) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008455@unknown@formal@none@1@S@These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nf-matp35") (:form . "NF-MATp35") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x905.9.1) (:span 14 27)))\n (:hscopes ((:id . :x905.9.1) (:span 14 130)))\n (:identifiers (:sid . :s905.9) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008456@unknown@formal@none@1@S@Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-MATp35") (:form . "NF-MATp35") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s905.10) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008457@unknown@formal@none@1@S@Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-MATp35") (:form . "NF-MATp35") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "excellent") (:form . "excellent") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 162) (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 195)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 71))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 210)\n  (:start . 203) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 218) (:start . 214)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 223) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 234)\n  (:start . 224) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s905.11) (:did . :|8626528|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008458@unknown@formal@none@1@S@Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation.@(((:tag . "NNP") (:stem . "Preassociation") (:form . "Preassociation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "STAT2") (:form . "STAT2") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "RB") (:stem . "prior") (:form . "prior") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 107)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s906.1) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008460@unknown@formal@none@1@S@Ligand-induced tyrosine phosphorylation of the STATs promotes their homodimer and heterodimer formation and subsequent nuclear translocation.@(((:tag . "JJ") (:stem . "ligand-induced") (:form . "Ligand-induced")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 39) (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STATs") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 67)\n  (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 93)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 103)\n  (:start . 94) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 118)\n  (:start . 108) (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 126)\n  (:start . 119) (:id . 56))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 140) (:start . 127) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s906.3) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008461@unknown@formal@none@1@S@We demonstrate here that STAT protein heterocomplexes exist prior to cytokine treatment.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "heterocomplex") (:form . "heterocomplexes")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "RB") (:stem . "prior") (:form . "prior") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s906.4) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008462@unknown@formal@none@1@S@When unstimulated HeLa cells are ruptured in hypotonic buffer without salt or detergent, immunoadsorption of either STAT1 or STAT2 from the resulting cytosol yields coimmunoadsorption of the other STAT protein.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "rupture") (:form . "ruptured") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hypotonic") (:form . "hypotonic") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "buffer") (:form . "buffer") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "salt") (:form . "salt") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "detergent") (:form . "detergent") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunoadsorption") (:form . "immunoadsorption")\n  (:end . 105) (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stat2") (:form . "STAT2") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "VBZ") (:stem . "yield") (:form . "yields") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "coimmunoadsorption") (:form . "coimmunoadsorption")\n  (:end . 183) (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 201) (:start . 197)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 209)\n  (:start . 202) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x906.5.1) (:span 109 115 122 124)))\n (:ncues ((:id . :x906.5.3) (:span 62 69)))\n (:hscopes ((:id . :x906.5.1) (:span 109 130)))\n (:nscopes ((:id . :x906.5.3) (:span 62 87)))\n (:identifiers (:sid . :s906.5) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008463@unknown@formal@none@1@S@Similarly, STAT1-STAT3 heterocomplexes are coimmunoadsorbed from hypotonic cytosol.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stat1-stat3") (:form . "STAT1-STAT3") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "heterocomplex") (:form . "heterocomplexes")\n  (:end . 38) (:start . 23) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "coimmunoadsorbe") (:form . "coimmunoadsorbed")\n  (:end . 59) (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hypotonic") (:form . "hypotonic") (:end . 74)\n  (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "cytosol") (:form . "cytosol") (:end . 82)\n  (:start . 75) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s906.6) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008464@unknown@formal@none@1@S@STAT1 and STAT2 or STAT1 and STAT3 translated in reticulocyte lysate spontaneously form heterocomplexes when the translation lysates are mixed at 0 degrees C.@(((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "STAT2") (:form . "STAT2") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "spontaneously") (:form . "spontaneously")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "heterocomplex") (:form . "heterocomplexes")\n  (:end . 103) (:start . 88) (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 132)\n  (:start . 125) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mix") (:form . "mixed") (:end . 142) (:start . 137)\n  (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 145) (:start . 143)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "JJ") (:stem . "c") (:form . "C") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s906.7) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008465@unknown@formal@none@1@S@Our data suggest that interferon-alpha /beta-induced tyrosine phosphorylation increases the stability of a preexisting, latent, STAT1-STAT2 signaling complex.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interferon-alpha") (:form . "interferon-alpha")\n  (:end . 38) (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "/beta-induced") (:form . "/beta-induced")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 77) (:start . 62) (:id . 49))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 87)\n  (:start . 78) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 101)\n  (:start . 92) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "preexisting") (:form . "preexisting") (:end . 118)\n  (:start . 107) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 126)\n  (:start . 120) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stat1-stat2") (:form . "STAT1-STAT2") (:end . 139)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 149)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 157)\n  (:start . 150) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x906.8.1) (:span 9 16)))\n (:hscopes ((:id . :x906.8.1) (:span 9 157)))\n (:identifiers (:sid . :s906.8) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008466@unknown@formal@none@1@S@Newly translated STAT1 binds in equilibrium fashion to STAT2 and STAT3, but we show that STAT2 and STAT3 exist in separate heterocomplexes with STAT1, consistent with a model in which STAT1 contains a common binding site for other STAT proteins.@(((:tag . "RB") (:stem . "newly") (:form . "Newly") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "equilibrium") (:form . "equilibrium") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT2") (:form . "STAT2") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stat2") (:form . "STAT2") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 104)\n  (:start . 99) (:id . 60))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "NNS") (:stem . "heterocomplex") (:form . "heterocomplexes")\n  (:end . 138) (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 161)\n  (:start . 151) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 183)\n  (:start . 178) (:id . 73))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 198)\n  (:start . 190) (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 200) (:start . 199)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 207)\n  (:start . 201) (:id . 77))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 215)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 220) (:start . 216)\n  (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 224) (:start . 221)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 230)\n  (:start . 225) (:id . 81))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 235) (:start . 231)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 244)\n  (:start . 236) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s906.9) (:did . :|8626752|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008467@unknown@formal@none@1@S@Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-kappa B is needed for persistent viral replication in monocytes.@(((:tag . "JJ") (:stem . "permanent") (:form . "Permanent") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 49) (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 95) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 128)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 141)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s907.1) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008468@unknown@formal@none@1@S@This work aimed to ascertain the role of kappaB-responsive elements of the human immunodeficiency virus type 1 (HIV-1) enhancer not only in early initiation but also in long-term maintenance of proviral transcription in cells of the monocytic lineage.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "aim") (:form . "aimed") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "ascertain") (:form . "ascertain") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "kappab-responsive") (:form . "kappaB-responsive")\n  (:end . 58) (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 97) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 178)\n  (:start . 169) (:id . 71))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 190)\n  (:start . 179) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 202)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 216) (:start . 203) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 242)\n  (:start . 233) (:id . 80))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 250)\n  (:start . 243) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s907.2) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008470@unknown@formal@none@1@S@The first was to abruptly terminate tumor necrosis factor-induced NF-kappaB binding to the enhancer sequences in U1 monocytic cells, using a short pulse of exogenous tumor necrosis factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "abruptly") (:form . "abruptly") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VB") (:stem . "terminate") (:form . "terminate") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "factor-induced") (:form . "factor-induced")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 138) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "pulse") (:form . "pulse") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 165)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 171)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 180)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 187)\n  (:start . 181) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s907.4) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008471@unknown@formal@none@1@S@This resulted in concomitant decrease in nuclear NF-kappaB DNA-binding activity and endogenous long terminal repeat transcriptional activity.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "concomitant") (:form . "concomitant") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 70)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 108)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 131) (:start . 116) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 140)\n  (:start . 132) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s907.5) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008472@unknown@formal@none@1@S@The second was to suppress the permanent NF-kappaB translocation induced by HIV-1 replication itself in chronically infected U937 cells, using a specific proteasome inhibitor (Z-LLL-H).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 115)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 142) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 174)\n  (:start . 165) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Z-LLL-H") (:form . "Z-LLL-H") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s907.6) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008473@unknown@formal@none@1@S@As early as 2 h after addition of the inhibitor to the culture medium, there was an inhibition of both constitutive activation of NF-kappaB and HIV-1 genome expression.@(((:tag . "RB") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 21) (:start . 16)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 30)\n  (:start . 22) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 76) (:start . 71)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 83) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 94)\n  (:start . 84) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 102) (:start . 98)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 115)\n  (:start . 103) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 126)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 139)\n  (:start . 130) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 167)\n  (:start . 157) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s907.7) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008474@unknown@formal@none@1@S@The third approach was to monitor the replication competence in U937 cells of an infectious HIV-1 provirus carrying point mutations in the kappaB-responsive elements of both long terminal repeats.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "monitor") (:form . "monitor") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "competence") (:form . "competence") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "kappab-responsive") (:form . "kappaB-responsive")\n  (:end . 156) (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 187)\n  (:start . 179) (:id . 69))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 195)\n  (:start . 188) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s907.8) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008475@unknown@formal@none@1@S@Compared with its wild-type counterpart, this mutated provirus showed a profoundly decreased, Z-LLL-H-insensitive transcriptional and replicative activity in U937 monocytes.@(((:tag . "VBN") (:stem . "compare") (:form . "Compared") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "counterpart") (:form . "counterpart") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 69) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "profoundly") (:form . "profoundly") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "z-lll-h-insensitive")\n  (:form . "Z-LLL-H-insensitive") (:end . 113) (:start . 94) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 129) (:start . 114) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 145)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 154)\n  (:start . 146) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 61))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 162) (:start . 158)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 172)\n  (:start . 163) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s907.9) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008476@unknown@formal@none@1@S@Together, our results indicate that occupancy of the viral enhancer by NF-kappaB (p50/p65) heterodimers is required for ongoing transcription of integrated HIV provirus in monocytes, even in cells chronically infected and permanently producing functional HIV Tat protein.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ongoing") (:form . "ongoing") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 155)\n  (:start . 145) (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 168)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 187) (:start . 183)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 208)\n  (:start . 197) (:id . 74))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 217)\n  (:start . 209) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . "RB") (:stem . "permanently") (:form . "permanently") (:end . 233)\n  (:start . 222) (:id . 77))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 243)\n  (:start . 234) (:id . 78))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 254)\n  (:start . 244) (:id . 79))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 258) (:start . 255)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 262) (:start . 259)\n  (:id . 81))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 270)\n  (:start . 263) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x907.10.1) (:span 22 35)))\n (:hscopes ((:id . :x907.10.1) (:span 22 270)))\n (:identifiers (:sid . :s907.10) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008477@unknown@formal@none@1@S@Thus, the ability of HIV-1 replication to activate NF-kappaB is crucial to the intense self-perpetuated viral transcription observed in cells of the monocytic lineage.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intense") (:form . "intense") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "self-perpetuated") (:form . "self-perpetuated")\n  (:end . 103) (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 123) (:start . 110) (:id . 59))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s907.11) (:did . :|8627768|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008478@unknown@formal@none@1@S@Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-kappaB and Sp1 binding elements.@(((:tag . "JJ") (:stem . "efficient") (:form . "Efficient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 66) (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 72) (:start . 67)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x908.1.1) (:span 80 87)))\n (:nscopes ((:id . :x908.1.1) (:span 80 125)))\n (:identifiers (:sid . :s908.1) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008480@unknown@formal@none@1@S@All mutants, including one extensively mutagenized strain entirely missing the NF-kappaB and four Spl binding elements, replicated with wild-type kinetics and to a wild-type level in peripheral blood mononuclear cell cultures in 50 to 100% of the experiments.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "mutagenize") (:form . "mutagenized") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "RB") (:stem . "entirely") (:form . "entirely") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "spl") (:form . "Spl") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "replicate") (:form . "replicated") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 154)\n  (:start . 146) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 193)\n  (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 199)\n  (:start . 194) (:id . 71))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 211)\n  (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 225)\n  (:start . 217) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 75))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 231) (:start . 229)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 234) (:start . 232)\n  (:id . 77))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 238) (:start . 235)\n  (:id . 78))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 239) (:start . 238)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 242) (:start . 240)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 258)\n  (:start . 247) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x908.3.1) (:span 67 74)))\n (:nscopes ((:id . :x908.3.1) (:span 67 118)))\n (:identifiers (:sid . :s908.3) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008481@unknown@formal@none@1@S@One group of mutants replicated very similarly to SIVmac239 in kinetics and yield in CEMxl74 cells (2xNFKappaB > or = SlVmac239 approximately deltaNFkappaB approximately deltaSpl234 approximately substNFkappaB approximately substSpl2 approximately substSp23), while a second group replicated with delayed or slightly delayed kinetics in CEMxl74 cells (SIVmac239 > substSp34 > deltaNFkappaBdeltaSpl234 approximately deltaNFkappaBdeltaSp1 > substSpl234).@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "replicate") (:form . "replicated") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "RB") (:stem . "very") (:form . 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5008482@unknown@formal@none@1@S@Reversions or additional mutations were not detected in the U3 and R regions of proviral DNA from CEMxl74 cells infected with the SIVmac239 mutants.@(((:tag . "NNS") (:stem . "reversion") (:form . "Reversions") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "r") (:form . "R") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cemxl74") (:form . "CEMxl74") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "SIVmac239") (:form . "SIVmac239") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x908.5.1) (:span 40 43)))\n (:nscopes ((:id . :x908.5.1) (:span 0 147)))\n (:identifiers (:sid . :s908.5) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008483@unknown@formal@none@1@S@Similar results were obtained when mutants of SIVmacMER (a macrophage-competent derivative of SIVmac239) were tested in peripheral blood mononuclear cell and CEMx174 cultures.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SIVmacMER") (:form . "SIVmacMER") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "macrophage-competent")\n  (:form . "macrophage-competent") (:end . 79) (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SIVmac239") (:form . "SIVmac239") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 148)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cemx174") (:form . "CEMx174") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s908.6) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5008485@unknown@formal@none@1@S@Thus, changes in the Sp1 binding sites had the most dramatic effects on SIVmac replication in primary macrophage cultures.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SIVmac") (:form . "SIVmac") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 112)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s908.8) (:did . :|8627791|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008486@unknown@formal@none@1@S@Analysis of long terminal repeat-driven secreted alkaline phosphatase activity in transient assays showed that, unlike human immunodeficiency virus type 1, the SIV long terminal repeat possesses an enhancer region just upstream of the NF-kappaB element which maintains significant levels of basal transcription in the absence of NF-kappaB and Sp1 sites.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "repeat-driven") (:form . "repeat-driven")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . 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5008490@unknown@formal@none@1@S@Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB.@(((:tag . "NN") (:stem . "inactivation") (:form . "Inactivation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 124)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x909.1.1) (:span 88 97)))\n (:hscopes ((:id . :x909.1.1) (:span 88 147)))\n (:identifiers (:sid . :s909.1) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008491@unknown@formal@none@1@S@In resting T lymphocytes, the transcription factor NF-kappaB is sequestered in the cytoplasm via interactions with members of the I kappa B family of inhibitors, including IkappaBalpha and IkappaBbeta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 10) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "sequester") (:form . "sequestered") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 109)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 160)\n  (:start . 150) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 171)\n  (:start . 162) (:id . 69))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 184) (:start . 172) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 200)\n  (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s909.2) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008492@unknown@formal@none@1@S@During normal T-cell activation, IkappaBalpha is rapidly phosphorylated, ubiquitinated, and degraded by the 26S proteasome, thus permitting the release of functional NF-kappaB.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "ubiquitinate") (:form . "ubiquitinated")\n  (:end . 86) (:start . 73) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "26s") (:form . "26S") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "permit") (:form . "permitting") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 175)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s909.3) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008493@unknown@formal@none@1@S@In contrast to its transient pattern of nuclear induction during an immune response, NF-kappaB is constitutively activated in cells expressing the Tax transforming protein of human T-cell leukemia virus type I (HTLV-1).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 112) (:start . 98) (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transforming") (:form . "transforming") (:end . 163)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 171)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 187)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 202)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 217)\n  (:start . 211) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s909.4) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008494@unknown@formal@none@1@S@Recent studies indicate that HTLV-1 Tax targets IkappaBalpha to the ubiquitin-proteasome pathway.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "target") (:form . "targets") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ubiquitin-proteasome")\n  (:form . "ubiquitin-proteasome") (:end . 88) (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x909.5.1) (:span 15 28)))\n (:hscopes ((:id . :x909.5.1) (:span 15 96)))\n (:identifiers (:sid . :s909.5) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008495@unknown@formal@none@1@S@However, it remains unclear how this viral protein induces a persistent rather than transient NF-kappaB response.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x909.6.2) (:span 20 27)))\n (:ncues ((:id . :x909.6.1) (:span 72 83)))\n (:hscopes ((:id . :x909.6.2) (:span 20 112)))\n (:nscopes ((:id . :x909.6.1) (:span 72 112)))\n (:identifiers (:sid . :s909.6) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008496@unknown@formal@none@1@S@In this report, we provide evidence that in addition to acting on IkappaBalpha, Tax stimulates the turnover Of IkappaBbeta via a related targeting mechanism.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 62) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 78)\n  (:start . 66) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "targeting") (:form . "targeting") (:end . 146)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 156)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s909.7) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008497@unknown@formal@none@1@S@Like IkappaBalpha, Tax-mediated breakdown of IkappaBbeta in transfected T lymphocytes is blocked either by cell-permeable proteasome inhibitors or by mutation Of IkappaBbeta at two serine residues present within its N-terminal region.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "tax-mediated") (:form . "Tax-mediated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "breakdown") (:form . "breakdown") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 71)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cell-permeable") (:form . "cell-permeable")\n  (:end . 121) (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 132)\n  (:start . 122) (:id . 58))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 143)\n  (:start . 133) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 146) (:start . 144)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 158)\n  (:start . 150) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 161) (:start . 159)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 173)\n  (:start . 162) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 176) (:start . 174)\n  (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 180) (:start . 177)\n  (:id . 66))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 187)\n  (:start . 181) (:id . 67))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 196)\n  (:start . 188) (:id . 68))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 204)\n  (:start . 197) (:id . 69))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 211)\n  (:start . 205) (:id . 70))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 215) (:start . 212)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 226)\n  (:start . 216) (:id . 72))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 233)\n  (:start . 227) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s909.8) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008498@unknown@formal@none@1@S@Despite the dual specificity of HTLV-1 Tax for IkappaBalpha and IkappaBbeta at the protein level, Tax selectively stimulates NF-kappaB-directed transcription of the IkappaBalpha gene.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "nf-kappab-directed") (:form . "NF-kappaB-directed")\n  (:end . 143) (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 177) (:start . 165) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 182) (:start . 178)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s909.9) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008500@unknown@formal@none@1@S@These findings with IkappaBbeta provide a potential mechanism for the constitutive activation of NF-kappaB in Tax-expressing cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 82)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 124) (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x909.11.1) (:span 42 51)))\n (:hscopes ((:id . :x909.11.1) (:span 42 130)))\n (:identifiers (:sid . :s909.11) (:did . :|8628274|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008501@unknown@formal@none@1@S@Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "stimulus-dependent") (:form . "stimulus-dependent")\n  (:end . 48) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s910.1) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008502@unknown@formal@none@1@S@The immediate-early gene egr-1 encodes a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream activation events through the regulation of previously unidentified target genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EGR1") (:form . "EGR1") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "link") (:form . "links") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "BCR") (:form . "BCR") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 186)\n  (:start . 176) (:id . 70))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 199)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 206)\n  (:start . 200) (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 212)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s910.2) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008503@unknown@formal@none@1@S@Here we identify the gene encoding the lymphocyte homing and migration protein CD44 as a target of EGR1 regulation in B cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "homing") (:form . "homing") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s910.3) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008504@unknown@formal@none@1@S@BCR-induced increases in CD44 mRNA expression and transcription levels are shown to occur in EGR1-expressing but not in nonexpressing subclones of the B-cell line WEHI-231.@(((:tag . "JJ") (:stem . "bcr-induced") (:form . "BCR-induced") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CD44") (:form . "CD44") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "egr1-expressing") (:form . "EGR1-expressing")\n  (:end . 108) (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nonexpressing") (:form . "nonexpressing")\n  (:end . 133) (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "subclone") (:form . "subclones") (:end . 143)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "wehi-231") (:form . "WEHI-231") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x910.4.1) (:span 113 116)))\n (:nscopes ((:id . :x910.4.1) (:span 113 171)))\n (:identifiers (:sid . :s910.4) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008505@unknown@formal@none@1@S@Kinetics of egr-1 transcription and the appearance of nuclear EGR1 protein precede CD44 induction and occur within 30 min after stimulation in the EGR1-expressing subclone.@(((:tag . "NNP") (:stem . "Kinetic") (:form . "Kinetics") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "VBP") (:stem . "precede") (:form . "precede") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "egr1-expressing") (:form . "EGR1-expressing")\n  (:end . 162) (:start . 147) (:id . 65))\n ((:tag . "NN") (:stem . "subclone") (:form . "subclone") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s910.5) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008506@unknown@formal@none@1@S@A single EGR1 binding motif is demonstrated at bp -301 of the human CD44 promoter.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "-301") (:form . "-301") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s910.6) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008507@unknown@formal@none@1@S@Cotransfection of a CD44 promoter-chloramphenicol acetyltransferase reporter construct with an egr-1 expression vector resulted in a 6.5- to 8.5-fold induction of transcriptional activity relative to an empty expression vector.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promoter-chloramphenicol")\n  (:form . "promoter-chloramphenicol") (:end . 49) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 67) (:start . 50) (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 76)\n  (:start . 68) (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 86)\n  (:start . 77) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 94) (:start . 92)\n  (:id . 51))\n ((:tag . "NN") (:stem . "egr-1") (:form . "egr-1") (:end . 100) (:start . 95)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 53))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 118)\n  (:start . 112) (:id . 54))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 127)\n  (:start . 119) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 57))\n ((:tag . "CD") (:stem . "6.5-") (:form . "6.5-") (:end . 137) (:start . 133)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "8.5-fold") (:form . "8.5-fold") (:end . 149)\n  (:start . 141) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 159)\n  (:start . 150) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 178) (:start . 163) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 187)\n  (:start . 179) (:id . 64))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 196)\n  (:start . 188) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 199) (:start . 197)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 202) (:start . 200)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "empty") (:form . "empty") (:end . 208)\n  (:start . 203) (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 219)\n  (:start . 209) (:id . 69))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 226)\n  (:start . 220) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s910.7) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008508@unknown@formal@none@1@S@The EGR1 binding motif was shown to be necessary for stimulus-induced expression of a CD44 promoter-chloramphenicol acetyltransferase reporter construct in nontransformed B lymphocytes and was required for transactivation by an EGR1 expression vector in a B-cell line.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "stimulus-induced") (:form . "stimulus-induced")\n  (:end . 69) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promoter-chloramphenicol")\n  (:form . "promoter-chloramphenicol") (:end . 115) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 133) (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 142)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 152)\n  (:start . 143) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nontransformed") (:form . "nontransformed")\n  (:end . 170) (:start . 156) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 172) (:start . 171)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 184)\n  (:start . 173) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 201)\n  (:start . 193) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 205) (:start . 202)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 221) (:start . 206) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 224) (:start . 222)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 227) (:start . 225)\n  (:id . 71))\n ((:tag . "NN") (:stem . "egr1") (:form . "EGR1") (:end . 232) (:start . 228)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 243)\n  (:start . 233) (:id . 73))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 250)\n  (:start . 244) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 253) (:start . 251)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 255) (:start . 254)\n  (:id . 76))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 262)\n  (:start . 256) (:id . 77))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 267) (:start . 263)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s910.8) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008510@unknown@formal@none@1@S@The relevance of these molecular events to BCR signal transduction and antigen-stimulated B-cell-mediated immune responses is discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "BCR") (:form . "BCR") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antigen-stimulated") (:form . "antigen-stimulated")\n  (:end . 89) (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "b-cell-mediated") (:form . "B-cell-mediated")\n  (:end . 105) (:start . 90) (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 112)\n  (:start . 106) (:id . 55))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 122)\n  (:start . 113) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s910.10) (:did . :|8628295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008511@unknown@formal@none@1@S@Identification of an inducible regulator of c-myb expression during T-cell activation.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s911.1) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008512@unknown@formal@none@1@S@Resting T cells express very low levels of c-Myb protein.@(((:tag . "VBG") (:stem . "rest") (:form . "Resting") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s911.2) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008513@unknown@formal@none@1@S@During T-cell activation, c-myb expression is induced and much of the increase in expression occurs at the transcriptional level.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "much") (:form . "much") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 122) (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s911.3) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008514@unknown@formal@none@1@S@We identified a region of the c-myb 5' flanking sequence that increased c-myb expression during T-cell activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s911.4) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008515@unknown@formal@none@1@S@In vivo footprinting by ligation-mediated PCR was performed to correlate in vivo protein binding with functional activity.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ligation-mediated") (:form . "ligation-mediated")\n  (:end . 41) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "pcr") (:form . "PCR") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s911.5) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008516@unknown@formal@none@1@S@A protein footprint was visible over this region of the c-myb 5' flanking sequence in activated T cells but not in unactivated T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "visible") (:form . "visible") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unactivated") (:form . "unactivated") (:end . 126)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x911.6.1) (:span 108 111)))\n (:nscopes ((:id . :x911.6.1) (:span 108 134)))\n (:identifiers (:sid . :s911.6) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008517@unknown@formal@none@1@S@An electrophoretic mobility shift assay (EMSA) with nuclear extract from activated T cells and an oligonucleotide of this binding site demonstrated a new protein-DNA complex, referred to as CMAT for c-myb in activated T cells; this complex was not present in unactivated T cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 113) (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 147)\n  (:start . 135) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 165)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 183)\n  (:start . 175) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CMAT") (:form . "CMAT") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 204)\n  (:start . 199) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 217)\n  (:start . 208) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 225)\n  (:start . 220) (:id . 79))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 226) (:start . 225)\n  (:id . 80))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 231) (:start . 227)\n  (:id . 81))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 239)\n  (:start . 232) (:id . 82))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 243) (:start . 240)\n  (:id . 83))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 247) (:start . 244)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 255)\n  (:start . 248) (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 258) (:start . 256)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "unactivated") (:form . "unactivated") (:end . 270)\n  (:start . 259) (:id . 87))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 272) (:start . 271)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 278)\n  (:start . 273) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 90)))@@@1@49@((:ncues ((:id . :x911.7.1) (:span 244 247)))\n (:nscopes ((:id . :x911.7.1) (:span 244 278)))\n (:identifiers (:sid . :s911.7) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008518@unknown@formal@none@1@S@Because the binding site showed some sequence similarity with the nuclear factor of activated T cells (NFAT) binding site, we compared the kinetics of induction of the two binding complexes and the molecular masses of the two proteins.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 160)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 179)\n  (:start . 172) (:id . 73))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 189)\n  (:start . 180) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 207)\n  (:start . 198) (:id . 77))\n ((:tag . "NNS") (:stem . "mass") (:form . "masses") (:end . 214)\n  (:start . 208) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 80))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 225) (:start . 222)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 234)\n  (:start . 226) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s911.8) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008520@unknown@formal@none@1@S@The NFAT protein migrated more slowly in a sodium dodecyl sulfate-polyacrylamide gel than the CMAT protein did.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "migrate") (:form . "migrated") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "slowly") (:form . "slowly") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "dodecyl") (:form . "dodecyl") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "sulfate-polyacrylamide")\n  (:form . "sulfate-polyacrylamide") (:end . 80) (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CMAT") (:form . "CMAT") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s911.10) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008521@unknown@formal@none@1@S@In addition, an antibody against NFAT did not cross-react with the CMAT protein.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VB") (:stem . "cross-react") (:form . "cross-react") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CMAT") (:form . "CMAT") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x911.11.1) (:span 42 45)))\n (:nscopes ((:id . :x911.11.1) (:span 42 79)))\n (:identifiers (:sid . :s911.11) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008522@unknown@formal@none@1@S@The appearance of the CMAT binding complex was inhibited by both cyclosporin A and rapamycin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CMAT") (:form . "CMAT") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rapamycin") (:form . "rapamycin") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s911.12) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008523@unknown@formal@none@1@S@The CMAT protein appears to be a novel inducible protein involved in the regulation of c-myb expression during T-cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CMAT") (:form . "CMAT") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-myb") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x911.13.1) (:span 17 24)))\n (:hscopes ((:id . :x911.13.1) (:span 0 128)))\n (:identifiers (:sid . :s911.13) (:did . :|8628306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008524@unknown@formal@none@1@S@Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.@(((:tag . "JJ") (:stem . "structural") (:form . "Structural") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 42) (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd36") (:form . "CD36") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 90) (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "pebp2/cbf") (:form . "PEBP2/CBF") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s912.1) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008525@unknown@formal@none@1@S@CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.@(((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thrombospondin") (:form . "thrombospondin")\n  (:end . 111) (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "collagen") (:form . "collagens") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 158)\n  (:start . 151) (:id . 68))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 170)\n  (:start . 159) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "anionic") (:form . "anionic") (:end . 192)\n  (:start . 185) (:id . 74))\n ((:tag . "NNS") (:stem . "phospholipid") (:form . "phospholipids")\n  (:end . 206) (:start . 193) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 224)\n  (:start . 212) (:id . 78))\n ((:tag . "VBN") (:stem . "parasitize") (:form . "parasitized") (:end . 236)\n  (:start . 225) (:id . 79))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 241) (:start . 237)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Plasmodium") (:form . "Plasmodium") (:end . 252)\n  (:start . 242) (:id . 81))\n ((:tag . "NNP") (:stem . "falciparum") (:form . "falciparum") (:end . 263)\n  (:start . 253) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s912.2) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008526@unknown@formal@none@1@S@Its expression is restricted to a few cell types, including monocyte/macrophages.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophages") (:end . 80) (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s912.3) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008527@unknown@formal@none@1@S@In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phagocytosis") (:form . "phagocytosis") (:end . 48)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "foam") (:form . "foam") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 138)\n  (:start . 127) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s912.4) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008528@unknown@formal@none@1@S@To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd36") (:form . "CD36") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s912.5) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008530@unknown@formal@none@1@S@Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBG") (:stem . "span") (:form . "spanning") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "CD") (:stem . "-158") (:form . "-158") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-90") (:form . "-90") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s912.7) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008531@unknown@formal@none@1@S@Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.@(((:tag . "JJ") (:stem . "biochemical") (:form . "Biochemical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "CD") (:stem . "-158/-90") (:form . "-158/-90") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "polyomavirus") (:form . "polyomavirus") (:end . 113)\n  (:start . 101) (:id . 57))\n ((:tag . "JJ") (:stem . "enhancer-binding") (:form . "enhancer-binding")\n  (:end . 130) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 59))\n ((:tag . "JJ") (:stem . "2/core-binding") (:form . "2/core-binding")\n  (:end . 153) (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 160)\n  (:start . 154) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PEBP2/CBF") (:form . "PEBP2/CBF") (:end . 171)\n  (:start . 162) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 179)\n  (:start . 173) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 182) (:start . 180)\n  (:id . 66))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 191)\n  (:start . 183) (:id . 67))\n ((:tag . "CD") (:stem . "-103") (:form . "-103") (:end . 196) (:start . 192)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s912.8) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008532@unknown@formal@none@1@S@Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.@(((:tag . "NN") (:stem . "disruption") (:form . "Disruption") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PEBP2/CBF") (:form . "PEBP2/CBF") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PEBP2/CBF") (:form . "PEBP2/CBF") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s912.9) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008533@unknown@formal@none@1@S@The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . 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"receptor") (:form . "receptor") (:end . 270)\n  (:start . 262) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 271) (:start . 270)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "highlight") (:form . "highlights") (:end . 282)\n  (:start . 272) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 286) (:start . 283)\n  (:id . 81))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 296)\n  (:start . 287) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 299) (:start . 297)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 303) (:start . 300)\n  (:id . 84))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 314)\n  (:start . 304) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 317) (:start . 315)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 321) (:start . 318)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "CD36") (:form . 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"PEBP2/CBF") (:end . 387)\n  (:start . 378) (:id . 98))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 394)\n  (:start . 388) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 395) (:start . 394)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s912.10) (:did . :|8631821|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008534@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 59)\n  (:start . 49) (:id . 45))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 64) (:start . 60)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 74)\n  (:start . 65) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 82)\n  (:start . 75) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 49))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 94)\n  (:start . 87) (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 104)\n  (:start . 95) (:id . 51))\n ((:tag . "NN") (:stem . "p93fes") (:form . "p93fes") (:end . 111)\n  (:start . 105) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 118)\n  (:start . 113) (:id . 54))\n ((:tag . "NN") (:stem . "p91") (:form . "p91") (:end . 122) (:start . 119)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 133)\n  (:start . 128) (:id . 58))\n ((:tag . "NN") (:stem . "p92") (:form . "p92") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 158) (:start . 141) (:id . 61))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 169)\n  (:start . 159) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s913.1) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008535@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation, differentiation, and functional activation of hemopoietic cells by its interaction with a heterodimeric receptor.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 56)\n  (:start . 50) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 67)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 81) (:start . 68) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 98) (:start . 83) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 114)\n  (:start . 104) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 125)\n  (:start . 115) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 140)\n  (:start . 129) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 153) (:start . 150)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 165)\n  (:start . 154) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 186) (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 195)\n  (:start . 187) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s913.2) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008536@unknown@formal@none@1@S@Although GM-CSF receptor is devoid of tyrosine kinase enzymatic activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional activation is mediated by the phosphorylation of a large number of intracellular signaling molecules.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "devoid") (:form . "devoid") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "gm-csf-induced") (:form . "GM-CSF-induced")\n  (:end . 88) (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 123) (:start . 106) (:id . 56))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 134)\n  (:start . 124) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 139) (:start . 136)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 151)\n  (:start . 141) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 165) (:start . 163)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 174)\n  (:start . 166) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 177) (:start . 175)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 197) (:start . 182) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 202) (:start . 201)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 208)\n  (:start . 203) (:id . 70))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 215)\n  (:start . 209) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 232) (:start . 219) (:id . 73))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 242)\n  (:start . 233) (:id . 74))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 252)\n  (:start . 243) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s913.3) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008537@unknown@formal@none@1@S@We have previously shown that JAK2 becomes tyrosine-phosphorylated in response to GM-CSF in PMN.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 66) (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s913.4) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008538@unknown@formal@none@1@S@In the present study we demonstrate that also the signal transducers and activators of transcription (STAT) family members STAT1 p91 and STAT3 p92 and the product of the c-fps/fes protooncogene become tyrosine-phosphorylated upon GM-CSF stimulation and physically associated with both GM-CSF receptor beta common subunit and JAK2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "STAT") (:form . 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"NN") (:stem . "product") (:form . "product") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "c-fps/fes") (:form . "c-fps/fes") (:end . 179)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 193) (:start . 180) (:id . 73))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 200)\n  (:start . 194) (:id . 74))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 224) (:start . 201) (:id . 75))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 229) (:start . 225)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 236)\n  (:start . 230) (:id . 77))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 248)\n  (:start . 237) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 252) (:start . 249)\n  (:id . 79))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 263)\n  (:start . 253) (:id . 80))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 274)\n  (:start . 264) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 279) (:start . 275)\n  (:id . 82))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 284) (:start . 280)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 291)\n  (:start . 285) (:id . 84))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 300)\n  (:start . 292) (:id . 85))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 305) (:start . 301)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 312)\n  (:start . 306) (:id . 87))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 320)\n  (:start . 313) (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 324) (:start . 321)\n  (:id . 89))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 329) (:start . 325)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 330) (:start . 329)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s913.5) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008540@unknown@formal@none@1@S@We also demonstrate that the association of the GM-CSF receptor beta common subunit with JAK2 is ligand-dependent.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "jak2") (:form . "JAK2") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ligand-dependent") (:form . "ligand-dependent")\n  (:end . 113) (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s913.7) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008541@unknown@formal@none@1@S@Finally we demonstrate that GM-CSF induces a DNA-binding complex that contains both p91 and p92.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p91") (:form . "p91") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p92") (:form . "p92") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s913.8) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008542@unknown@formal@none@1@S@These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "gm-csf-stimulated") (:form . "GM-CSF-stimulated")\n  (:end . 161) (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 165) (:start . 162)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s913.9) (:did . :|8631962|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008543@unknown@formal@none@1@S@CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.@(((:tag . "NNP") (:stem . "CNI-1493") (:form . "CNI-1493") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 37) (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 43) (:start . 38)\n  (:id . 45))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 52)\n  (:start . 44) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 74)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 89)\n  (:start . 78) (:id . 51))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 100)\n  (:start . 90) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s914.1) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008544@unknown@formal@none@1@S@Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "JJ") (:stem . "septic") (:form . "septic") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 124)\n  (:start . 112) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cachexia") (:form . "cachexia") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s914.2) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008545@unknown@formal@none@1@S@Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K.R., Tortolani, A.J., Cerami, A.& Tracey, K.J.(1995) Mol.Med.1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P. S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A.& Tracey, J.(1996) J.Exp.Med., in press].@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multivalent") (:form . 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5008546@unknown@formal@none@1@S@We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CNI-1493") (:form . "CNI-1493") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 135)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s914.4) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008547@unknown@formal@none@1@S@CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.@(((:tag . "NNP") (:stem . "CNI-1493") (:form . "CNI-1493") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 47) (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . 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5008548@unknown@formal@none@1@S@However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "26-kda") (:form . "26-kDa") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CNI-1493") (:form . "CNI-1493") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s914.6) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008550@unknown@formal@none@1@S@Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 18) (:start . 17)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "untranslated") (:form . "untranslated") (:end . 31)\n  (:start . 19) (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 39)\n  (:start . 32) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 50) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 69)\n  (:start . 61) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "VB") (:stem . "elicit") (:form . "elicit") (:end . 79)\n  (:start . 73) (:id . 58))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 87)\n  (:start . 80) (:id . 59))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 101) (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 113)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CNI-1493") (:form . "CNI-1493") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s914.8) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008551@unknown@formal@none@1@S@Identification of the molecular target through which CNI- 1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cni-") (:form . "CNI-") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1493") (:form . "1493") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 170)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 186)\n  (:start . 174) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x914.9.1) (:span 88 94)))\n (:hscopes ((:id . :x914.9.1) (:span 88 186)))\n (:identifiers (:sid . :s914.9) (:did . :|8632999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008552@unknown@formal@none@1@S@STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.@(((:tag . "JJ") (:stem . "stat-related") (:form . "STAT-related") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 34)\n  (:start . 27) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 53) (:start . 39) (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 63)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 77)\n  (:start . 67) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 100) (:start . 95)\n  (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 118)\n  (:start . 110) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s915.1) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008553@unknown@formal@none@1@S@A signal transduction pathway activated by many cytokines has recently been elaborated.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "elaborate") (:form . "elaborated") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s915.2) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008554@unknown@formal@none@1@S@The JAK kinases and the signal transducers and activators of transcription (STAT) factors have been found to be essential components.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "jak") (:form . "JAK") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s915.3) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008555@unknown@formal@none@1@S@In this report, we describe the presence of constitutively activated STAT factors in peripheral blood cells from patients with acute leukemia.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 58) (:start . 44) (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s915.4) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008556@unknown@formal@none@1@S@We used oligonucleotide probes from the beta-casein and IRF-1 gene promoters and the ISRE probe to detect STAT proteins in nuclear extracts from acute leukemia cells in bandshift assays.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 23) (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ISRE") (:form . "ISRE") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bandshift") (:form . "bandshift") (:end . 178)\n  (:start . 169) (:id . 69))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 185)\n  (:start . 179) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s915.5) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008557@unknown@formal@none@1@S@Specific DNA protein complex formation was observed with the probes from the beta-casein and IRF-1 gene promoters, but not with the ISRE oligonucleotide probe, when cell extracts from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were investigated.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "ISRE") (:form . "ISRE") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 152) (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 164) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 203) (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 212)\n  (:start . 204) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 214) (:start . 213)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "ALL") (:form . "ALL") (:end . 217) (:start . 214)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 218) (:start . 217)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 228)\n  (:start . 223) (:id . 79))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 236)\n  (:start . 229) (:id . 80))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 245)\n  (:start . 237) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 247) (:start . 246)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "AML") (:form . "AML") (:end . 250) (:start . 247)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 84))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 256) (:start . 252)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 269)\n  (:start . 257) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x915.6.1) (:span 119 122)))\n (:nscopes ((:id . :x915.6.1) (:span 119 158)))\n (:identifiers (:sid . :s915.6) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008558@unknown@formal@none@1@S@We used nonradioactive oligonucleotides as competitors to show the specificity of the complex formation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nonradioactive") (:form . "nonradioactive")\n  (:end . 22) (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 39) (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "competitor") (:form . "competitors") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 103)\n  (:start . 94) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s915.7) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008560@unknown@formal@none@1@S@STAT5- and STAT1-related factors were detected in ALL and STAT1-, STAT3-, and STAT5-related proteins were present in nuclear cell extracts from AML.@(((:tag . "NN") (:stem . "stat5-") (:form . "STAT5-") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "stat1-related") (:form . "STAT1-related")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ALL") (:form . "ALL") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "STAT1-") (:form . "STAT1-") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stat3-") (:form . "STAT3-") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "stat5-related") (:form . "STAT5-related")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "AML") (:form . "AML") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s915.9) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008561@unknown@formal@none@1@S@Since the cells were not treated with cytokines before the nuclear proteins were extracted, we conclude that these factors are constitutively activated in vivo.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 141) (:start . 127) (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x915.10.1) (:span 21 24)))\n (:nscopes ((:id . :x915.10.1) (:span 6 90)))\n (:identifiers (:sid . :s915.10) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008562@unknown@formal@none@1@S@It is likely that the constitutive activation of STAT proteins is a part of the events of leukemogenesis.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "leukemogenesis") (:form . "leukemogenesis")\n  (:end . 104) (:start . 90) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x915.11.1) (:span 6 12)))\n (:hscopes ((:id . :x915.11.1) (:span 6 104)))\n (:identifiers (:sid . :s915.11) (:did . :|8634413|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008563@unknown@formal@none@1@S@Reversible differentiation of human monoblastic leukemia U937 cells by ML-9, an inhibitor of myosin light chain kinase.@(((:tag . "JJ") (:stem . "reversible") (:form . "Reversible") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 26) (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "myosin") (:form . "myosin") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s916.1) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008564@unknown@formal@none@1@S@Human monoblastic leukemia U937 cells are induced to differentiate into monocytes and macrophages by various agents.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 97)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s916.2) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008565@unknown@formal@none@1@S@We have shown that 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9), an inhibitor of myosin light chain kinase, induces differentiation of monocytoid leukemia cell lines U937 and THP-1 but not of myeloblastic leukemic ML-1 cell or erythroleukemia K562 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ")\n  (:stem . "1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine")\n  (:form . "1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine")\n  (:end . 80) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "hydrochloride") (:form . "hydrochloride")\n  (:end . 94) (:start . 81) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 100) (:start . 96)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 115)\n  (:start . 106) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 54))\n ((:tag . "NN") (:stem . "myosin") (:form . "myosin") (:end . 125)\n  (:start . 119) (:id . 55))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 131)\n  (:start . 126) (:id . 56))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 137)\n  (:start . 132) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 144)\n  (:start . 138) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 153)\n  (:start . 146) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 169) (:start . 154) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 183)\n  (:start . 173) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 192)\n  (:start . 184) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 197) (:start . 193)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 203)\n  (:start . 198) (:id . 66))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 208) (:start . 204)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 68))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 218)\n  (:start . 213) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 222) (:start . 219)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 226) (:start . 223)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "myeloblastic") (:form . "myeloblastic") (:end . 242)\n  (:start . 230) (:id . 73))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 251)\n  (:start . 243) (:id . 74))\n ((:tag . "NN") (:stem . "ml-1") (:form . "ML-1") (:end . 256) (:start . 252)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 261) (:start . 257)\n  (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 264) (:start . 262)\n  (:id . 77))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 280) (:start . 265) (:id . 78))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 285) (:start . 281)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 291)\n  (:start . 286) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x916.3.1) (:span 223 226)))\n (:nscopes ((:id . :x916.3.1) (:span 223 291)))\n (:identifiers (:sid . :s916.3) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008566@unknown@formal@none@1@S@In the present study, we further analyzed the effect of ML-9 in comparison with that of 1 alpha, 25-dihydroxyvitamin D3 (VD3) a typical inducer of monocytic differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 89) (:start . 88)\n  (:id . 59))\n ((:tag . "SYM") (:stem . "alpha") (:form . "alpha") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . "NN") (:stem . "25-dihydroxyvitamin")\n  (:form . "25-dihydroxyvitamin") (:end . 116) (:start . 97) (:id . 62))\n ((:tag . "NNP") (:stem . "D3") (:form . "D3") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "VD3") (:form . "VD3") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 135)\n  (:start . 128) (:id . 68))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 143)\n  (:start . 136) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 156)\n  (:start . 147) (:id . 71))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 172) (:start . 157) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s916.4) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008567@unknown@formal@none@1@S@ML-9 induced nitroblue tetrazolium (NBT)-reducing activity of U937 cell more rapidly than VD3: This differentiation marker was induced significantly after incubation with ML-9 and VD3 for 4 hours and 1 day, respectively.@(((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "nitroblue") (:form . "nitroblue") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "tetrazolium") (:form . "tetrazolium") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "NBT)-reducing") (:form . "NBT)-reducing")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "vd3") (:form . "VD3") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "This") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 115) (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 148) (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 175) (:start . 171)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "VD3") (:form . "VD3") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 189) (:start . 188)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 195)\n  (:start . 190) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 201) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 219)\n  (:start . 207) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s916.5) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008568@unknown@formal@none@1@S@ML-9 also induced alpha-naphthyl acetate esterase (ANAE) activity, another monocytic differentiation marker, more rapidly than VD3.@(((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "alpha-naphthyl") (:form . "alpha-naphthyl")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "esterase") (:form . "esterase") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ANAE") (:form . "ANAE") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 100) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "VD3") (:form . "VD3") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s916.6) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008570@unknown@formal@none@1@S@The growth inhibition of U937 cells by ML-9 was also reversible.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s916.8) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008571@unknown@formal@none@1@S@Similar effects were observed in another line of human monoblastic cells, THP-1.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monoblastic") (:form . "monoblastic") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s916.9) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008572@unknown@formal@none@1@S@ML-9 had little or no effect on the morphology of U937 cells but increased the expression of monocyte-macrophage lineage-associated surface antigen, CD14, to some extent.@(((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 46)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 74)\n  (:start . 65) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophage") (:end . 112) (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "lineage-associated") (:form . "lineage-associated")\n  (:end . 131) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 162) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 169)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x916.10.1) (:span 19 21)))\n (:nscopes ((:id . :x916.10.1) (:span 19 60)))\n (:identifiers (:sid . :s916.10) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008573@unknown@formal@none@1@S@Irreversible terminal differentiation induced by VD3 is associated with down regulation of the expression of c-myc and upregulation of the expression of c-fos and c-jun, but ML-9 did not affect the expression of these oncogenes appreciably.@(((:tag . "JJ") (:stem . "irreversible") (:form . "Irreversible") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 37) (:start . 22) (:id . 44))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 45)\n  (:start . 38) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "VD3") (:form . "VD3") (:end . 52) (:start . 49)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "down") (:form . "down") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 131)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 158)\n  (:start . 153) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 193)\n  (:start . 187) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 208)\n  (:start . 198) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 217)\n  (:start . 212) (:id . 76))\n ((:tag . "NNS") (:stem . "oncogene") (:form . "oncogenes") (:end . 227)\n  (:start . 218) (:id . 77))\n ((:tag . "RB") (:stem . "appreciably") (:form . "appreciably") (:end . 239)\n  (:start . 228) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x916.11.1) (:span 183 186)))\n (:nscopes ((:id . :x916.11.1) (:span 183 239)))\n (:identifiers (:sid . :s916.11) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008574@unknown@formal@none@1@S@ML-9-induced differentiation was also reversible when the cells were cultured with cultured with ML-9 plus an anti-cancer drug such as 1-beta-D-arabino-furanosylcytosine or daunomycin.@(((:tag . "JJ") (:stem . "ml-9-induced") (:form . "ML-9-induced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 28) (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "reversible") (:form . "reversible") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 53) (:start . 49)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "anti-cancer") (:form . "anti-cancer") (:end . 121)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "1-beta-d-arabino-furanosylcytosine")\n  (:form . "1-beta-D-arabino-furanosylcytosine") (:end . 169) (:start . 135)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 172) (:start . 170)\n  (:id . 63))\n ((:tag . "NN") (:stem . "daunomycin") (:form . "daunomycin") (:end . 183)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s916.12) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008575@unknown@formal@none@1@S@it became irreversible, however, upon simultaneous treatment with dexamethasone and transforming growth factor-beta 1 (TGF-beta 1), which did not induce differentiation of U937 cells but caused growth arrest of the cells in the G0/G1 phase of the cell cycle.@(((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "become") (:form . "became") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 96)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 115)\n  (:start . 104) (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 117) (:start . 116)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 168) (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 176) (:start . 172)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 186) (:start . 183)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 193)\n  (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 207)\n  (:start . 201) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 79))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 233)\n  (:start . 228) (:id . 80))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 239)\n  (:start . 234) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 242) (:start . 240)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 83))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 251) (:start . 247)\n  (:id . 84))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 257)\n  (:start . 252) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x916.13.1) (:span 142 145)))\n (:nscopes ((:id . :x916.13.1) (:span 142 182)))\n (:identifiers (:sid . :s916.13) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008576@unknown@formal@none@1@S@These results suggest that ML-9 should be useful for studying the mechanisms of monocytic differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ML-9") (:form . "ML-9") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 105) (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x916.14.1) (:span 32 38))\n  ((:id . :x916.14.2) (:span 14 21)))\n (:hscopes ((:id . :x916.14.1) (:span 32 105))\n  ((:id . :x916.14.2) (:span 14 105)))\n (:identifiers (:sid . :s916.14) (:did . :|8635523|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008577@unknown@formal@none@1@S@Interferon-gamma modulates the lipopolysaccharide-induced expression of AP-1 and NF-kappa B at the mRNA and protein level in human monocytes.@(((:tag . "NNP") (:stem . "Interferon-gamma") (:form . "Interferon-gamma")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 57) (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 76) (:start . 72)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 89)\n  (:start . 81) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 121)\n  (:start . 116) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s917.1) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008578@unknown@formal@none@1@S@Interferon-gamma (IFN-gamma) modulates the expression of several cytokines by human monocytes at the transcriptional level.@(((:tag . "NNP") (:stem . "Interferon-gamma") (:form . "Interferon-gamma")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 116) (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s917.2) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008580@unknown@formal@none@1@S@Priming of human monocytes with IFN-gamma resulted in the down regulation of c-fos and c-jun mRNA in response to stimulation with lipopolysaccharide (LPS) compared to the effects of LPS alone.@(((:tag . "NN") (:stem . "priming") (:form . "Priming") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "down") (:form . "down") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 148) (:start . 130) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 163)\n  (:start . 155) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 178)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 191)\n  (:start . 186) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s917.4) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008581@unknown@formal@none@1@S@Not only was this effect observed at the mRNA level, but activator protein-1 (AP-1) DNA binding capacity was affected as well, A strong reduction was observed in the LPS-induced DNA-binding activity of AP-1 in the presence of IFN-gamma.@(((:tag . "RB") (:stem . "not") (:form . "Not") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 66)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 117)\n  (:start . 109) (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 135)\n  (:start . 129) (:id . 68))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 145)\n  (:start . 136) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 158)\n  (:start . 150) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 177)\n  (:start . 166) (:id . 74))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 189)\n  (:start . 178) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 198)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 206) (:start . 202)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 209) (:start . 207)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 80))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 222)\n  (:start . 214) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 225) (:start . 223)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 235)\n  (:start . 226) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s917.5) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008582@unknown@formal@none@1@S@LPS-stimulated monocytes showed an increased expression of p105 mRNA, the precursor of the p50 subunit of the transcription factor nuclear factor-kappa B (NF-kappa B), while no effect was noticed on the expression of p65 mRNA.@(((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 31) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 123) (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 151)\n  (:start . 139) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 173)\n  (:start . 168) (:id . 70))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 183)\n  (:start . 177) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "notice") (:form . "noticed") (:end . 195)\n  (:start . 188) (:id . 74))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 198) (:start . 196)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 213)\n  (:start . 203) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 78))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 220) (:start . 217)\n  (:id . 79))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x917.6.1) (:span 174 176)))\n (:nscopes ((:id . :x917.6.1) (:span 174 225)))\n (:identifiers (:sid . :s917.6) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008583@unknown@formal@none@1@S@In contrast, IFN-gamma priming did not affect the expression of p105 transcripts but enhanced the expression of p65 mRNA (two-fold).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "two-fold") (:form . "two-fold") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x917.7.1) (:span 35 38)))\n (:nscopes ((:id . :x917.7.1) (:span 35 80)))\n (:identifiers (:sid . :s917.7) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008584@unknown@formal@none@1@S@Priming with IFN-gamma followed by LPS stimulation resulted in a further increase in the expression of p65 mRNA.@(((:tag . "VBG") (:stem . "prim") (:form . "Priming") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s917.8) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008585@unknown@formal@none@1@S@This was due to an increase in the half-life of p65 mRNA (75 vs 150 minutes).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 60) (:start . 58)\n  (:id . 55))\n ((:tag . "IN") (:stem . "vs") (:form . "vs") (:end . 63) (:start . 61)\n  (:id . 56))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 67) (:start . 64)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 75)\n  (:start . 68) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s917.9) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008586@unknown@formal@none@1@S@Electrophoretic mobility shift assays (EMSAs) demonstrated that unstimulated monocytes predominantly expressed p50 NF-kappa B.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 100) (:start . 87) (:id . 53))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 110)\n  (:start . 101) (:id . 54))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 114) (:start . 111)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s917.10) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008587@unknown@formal@none@1@S@Stimulation with LPS or IFN-gamma resulted in the expression of p50 and p65 subunits, while the combination of IFN-gamma plus LPS caused a further increase in the expression of NF-kappa B.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 107)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 155)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 185)\n  (:start . 177) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s917.11) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008588@unknown@formal@none@1@S@With Western blotting, it was shown that nuclear extracts from monocytes contained p50 and p65 protein in response to LPS and IFN-gamma stimulation.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Western") (:form . "Western") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 147)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s917.12) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008590@unknown@formal@none@1@S@The effects of IFN-gamma on the transcription factors were specific, since no change was observed in the expression of NF-IL-6 or I kappa B alpha, the inhibitor of NF-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-IL-6") (:form . "NF-IL-6") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 160)\n  (:start . 151) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 172)\n  (:start . 164) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x917.14.1) (:span 75 77)))\n (:nscopes ((:id . :x917.14.1) (:span 75 174)))\n (:identifiers (:sid . :s917.14) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008591@unknown@formal@none@1@S@We conclude that the effects of IFN-gamma on the expression of the transcription factors AP-1 and NF-kappa B may be important for the modulatory effects of IFN-gamma on the cytokine expression in activated human monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "modulatory") (:form . "modulatory") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 165)\n  (:start . 156) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 192)\n  (:start . 182) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 205)\n  (:start . 196) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 211)\n  (:start . 206) (:id . 75))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 221)\n  (:start . 212) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x917.15.1) (:span 109 112)))\n (:hscopes ((:id . :x917.15.1) (:span 109 221)))\n (:identifiers (:sid . :s917.15) (:did . :|8641346|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008592@unknown@formal@none@1@S@Expression of c-fos and c-jun proteins and AP-1 binding activity during cell cycle progression of HL60 cells and phytohemagglutinin-stimulated lymphocytes.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "phytohemagglutinin-stimulated")\n  (:form . "phytohemagglutinin-stimulated") (:end . 142) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 154)\n  (:start . 143) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s918.1) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008593@unknown@formal@none@1@S@The protein products of the c-fos (p62c-fos) and c-jun (p39c-jun) genes are members of the AP-1 transcription factor family and are thought to play important roles in the regulation of gene expression during the cell cycle.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 83)\n  (:start . 76) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 157)\n  (:start . 148) (:id . 70))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 163)\n  (:start . 158) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 73))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 181)\n  (:start . 171) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 200)\n  (:start . 190) (:id . 77))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 207)\n  (:start . 201) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 222)\n  (:start . 217) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x918.2.1) (:span 132 139)))\n (:hscopes ((:id . :x918.2.1) (:span 128 222)))\n (:identifiers (:sid . :s918.2) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008594@unknown@formal@none@1@S@Most studies on the expression of these proteins in relation to the cell cycle have been performed at the mRNA level, and therefore do not give direct information about the presence of the proteins during the cell cycle.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 131)\n  (:start . 122) (:id . 65))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "VB") (:stem . "give") (:form . "give") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 162)\n  (:start . 151) (:id . 70))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 181)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 197)\n  (:start . 189) (:id . 76))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 204)\n  (:start . 198) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 213) (:start . 209)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 219)\n  (:start . 214) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x918.3.1) (:span 135 138)))\n (:nscopes ((:id . :x918.3.1) (:span 135 219)))\n (:identifiers (:sid . :s918.3) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008595@unknown@formal@none@1@S@We have used Western blotting to investigate the presence of these proteins during the cell cycles of two different cellular systems: a continuously growing myeloid leukemic cell line, HL60, and normal cells stimulated into cycle, phyto- hemagglutinin (PHA)-stimulated normal human peripheral blood lymphocytes (PBL).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "investigate") (:form . 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"into") (:end . 223) (:start . 219)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 229)\n  (:start . 224) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 80))\n ((:tag . "NN") (:stem . "phyto-") (:form . "phyto-") (:end . 237)\n  (:start . 231) (:id . 81))\n ((:tag . "NN") (:stem . "hemagglutinin") (:form . "hemagglutinin")\n  (:end . 251) (:start . 238) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 253) (:start . 252)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "PHA)-stimulated") (:form . "PHA)-stimulated")\n  (:end . 268) (:start . 253) (:id . 84))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 275)\n  (:start . 269) (:id . 85))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 281)\n  (:start . 276) (:id . 86))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 292)\n  (:start . 282) (:id . 87))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 298)\n  (:start . 293) (:id . 88))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 310)\n  (:start . 299) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 312) (:start . 311)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 315) (:start . 312)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 316) (:start . 315)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 317) (:start . 316)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s918.4) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008596@unknown@formal@none@1@S@The binding activity of transcription factor AP-1, which consists of dimers of Fos and Jun family proteins, was also studied using a gel shift assay.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 130) (:start . 125)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s918.5) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008597@unknown@formal@none@1@S@We found nuclear p62c-fos, p39c-jun, and AP-1 binding activity throughout the cell cycle both in HL60 cells and in PHA-stimulated PBL, and we postulate that these proteins are required throughout the cell cycle and not transiently in the G0 to G1 transition as previous mRNA studies have indicated.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pha-stimulated") (:form . "PHA-stimulated")\n  (:end . 129) (:start . 115) (:id . 63))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "postulate") (:form . "postulate") (:end . 151)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 171)\n  (:start . 163) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 184)\n  (:start . 176) (:id . 73))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 195)\n  (:start . 185) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 204) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 210)\n  (:start . 205) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 218) (:start . 215)\n  (:id . 79))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 230)\n  (:start . 219) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 82))\n ((:tag . "NN") (:stem . "g0") (:form . "G0") (:end . 240) (:start . 238)\n  (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 243) (:start . 241)\n  (:id . 84))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 246) (:start . 244)\n  (:id . 85))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 257)\n  (:start . 247) (:id . 86))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 260) (:start . 258)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 269)\n  (:start . 261) (:id . 88))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 274) (:start . 270)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 282)\n  (:start . 275) (:id . 90))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 287) (:start . 283)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 297)\n  (:start . 288) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 298) (:start . 297)\n  (:id . 93)))@@@1@52@((:ncues ((:id . :x918.6.1) (:span 215 218)))\n (:nscopes ((:id . :x918.6.1) (:span 215 257)))\n (:identifiers (:sid . :s918.6) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008598@unknown@formal@none@1@S@We demonstrated an uncoupling of AP-1 binding activity from p62c-fos, and p39c-jun AP-1 activity was expressed more strongly in the G1- and G2/M-phase enriched samples than in the S-phase enriched samples of HL60 cells, while levels of nuclear p62c-fos and p39c-jun were constant.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "uncoupling") (:form . "uncoupling") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "G1-") (:form . "G1-") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "G2/M-phase") (:form . "G2/M-phase") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "JJ") (:stem . "enriched") (:form . "enriched") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "S-phase") (:form . "S-phase") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "JJ") (:stem . "enriched") (:form . "enriched") (:end . 196)\n  (:start . 188) (:id . 72))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 204)\n  (:start . 197) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 212) (:start . 208)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 77))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 225)\n  (:start . 220) (:id . 78))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 232)\n  (:start . 226) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 243)\n  (:start . 236) (:id . 81))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 252)\n  (:start . 244) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 256) (:start . 253)\n  (:id . 83))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 265)\n  (:start . 257) (:id . 84))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 270) (:start . 266)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "constant") (:form . "constant") (:end . 279)\n  (:start . 271) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s918.7) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008600@unknown@formal@none@1@S@Following PHA stimulation of PBL, the increase in AP-1 activity was delayed with respect to the augmentation of p39c-jun expression.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "PHA") (:form . "PHA") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "augmentation") (:form . "augmentation") (:end . 108)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s918.9) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008601@unknown@formal@none@1@S@We also observed that cytoplasmic p62c-fos and p39c-jun were present in HL60 cells and PHA-stimulated PBL.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hl60") (:form . "HL60") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pha-stimulated") (:form . "PHA-stimulated")\n  (:end . 101) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s918.10) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008602@unknown@formal@none@1@S@However, no cytoplasmic p62c-fos was detected in unstimulated PBL, although in some cases cytoplasmic p39c-jun was detected, suggesting that subcellular compartmentalization of these proteinsmay occur under certain circumstances.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "p62c-fos") (:form . "p62c-fos") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "p39c-jun") (:form . "p39c-jun") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "compartmentalization")\n  (:form . "compartmentalization") (:end . 173) (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 182)\n  (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "proteinsmay") (:form . "proteinsmay") (:end . 194)\n  (:start . 183) (:id . 68))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 200)\n  (:start . 195) (:id . 69))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 206)\n  (:start . 201) (:id . 70))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 214)\n  (:start . 207) (:id . 71))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 228) (:start . 215) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x918.11.1) (:span 125 135)))\n (:ncues ((:id . :x918.11.2) (:span 9 11)))\n (:hscopes ((:id . :x918.11.1) (:span 125 228)))\n (:nscopes ((:id . :x918.11.2) (:span 9 65)))\n (:identifiers (:sid . :s918.11) (:did . :|8641353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008603@unknown@formal@none@1@S@Involvement of intracellular Ca2+ in oxidant-induced NF-kappa B activation.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oxidant-induced") (:form . "oxidant-induced")\n  (:end . 52) (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s919.1) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008604@unknown@formal@none@1@S@In human Jurkat T cells and its subclone Wurzburg cells oxidant challenge elevated [Ca2+]i by mobilizing Ca2+ from intracellular stores.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 15)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subclone") (:form . "subclone") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oxidant") (:form . "oxidant") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "mobilize") (:form . "mobilizing") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 128) (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "store") (:form . "stores") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s919.2) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008605@unknown@formal@none@1@S@In Jurkat cells this effect was rapid and transient, but in Wurzburg cells the response was slow and sustained.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s919.3) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008606@unknown@formal@none@1@S@H2O2-induced NF-kappaB activation in Wurzburg cells was not influenced by the presence of extracellular EGTA but was totally inhibited in cells that were loaded with esterified EGTA.@(((:tag . "JJ") (:stem . "h2o2-induced") (:form . "H2O2-induced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Wurzburg") (:form . "Wurzburg") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 103) (:start . 90) (:id . 55))\n ((:tag . "NNP") (:stem . "EGTA") (:form . "EGTA") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "load") (:form . "loaded") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "esterify") (:form . "esterified") (:end . 176)\n  (:start . 166) (:id . 67))\n ((:tag . "NNP") (:stem . "EGTA") (:form . "EGTA") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x919.4.1) (:span 56 59)))\n (:nscopes ((:id . :x919.4.1) (:span 0 108)))\n (:identifiers (:sid . :s919.4) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008607@unknown@formal@none@1@S@In Jurkat cells that are not sensitive to H2O2-induced NF-kappaB activation, H2O2 potentiated NF-kappaB activation in the presence of sustained high [Ca2+]i following thapsigargin treatment.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "h2o2-induced") (:form . "H2O2-induced") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "potentiate") (:form . "potentiated") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 156)\n  (:start . 150) (:id . 65))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 166)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "thapsigargin") (:form . "thapsigargin") (:end . 179)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 189)\n  (:start . 180) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x919.5.1) (:span 25 28)))\n (:nscopes ((:id . :x919.5.1) (:span 25 75)))\n (:identifiers (:sid . :s919.5) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008608@unknown@formal@none@1@S@NF-kappaB regulatory effect of alpha-lipoate and N-acetylcysteine appeared to be, at least in part, due to their ability to stabilize elevation of [Ca2+]i following oxidant challenge.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha-lipoate") (:form . "alpha-lipoate")\n  (:end . 44) (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 65) (:start . 49) (:id . 48))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "VB") (:stem . "stabilize") (:form . "stabilize") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ca2+]i") (:form . "Ca2+]i") (:end . 154)\n  (:start . 148) (:id . 67))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 164)\n  (:start . 155) (:id . 68))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 172)\n  (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 182)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x919.6.1) (:span 66 74)))\n (:hscopes ((:id . :x919.6.1) (:span 0 182)))\n (:identifiers (:sid . :s919.6) (:did . :|8641467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008610@unknown@formal@none@1@S@A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 20) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s920.1) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008611@unknown@formal@none@1@S@The costimulatory molecule B7.1 provides a second signal critical for T cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s920.2) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008612@unknown@formal@none@1@S@The distribution of this integral membrane protein is restricted to certain tissues where its level of expression is modulated by multiple exogenous stimuli.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "integral") (:form . "integral") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s920.3) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008613@unknown@formal@none@1@S@To identify the molecular basis for specificity and inducibility, the chromatin configuration of the human B7.1 gene was examined in intact nuclei from various cell types.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "configuration") (:form . "configuration")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s920.4) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008614@unknown@formal@none@1@S@The identification of a tissue-specific deoxyribonuclease I hypersensitive site approximately 3kb upstream of the transcription start site led to the characterization of a cell type-specific enhancer region.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "deoxyribonuclease") (:form . "deoxyribonuclease")\n  (:end . 57) (:start . 40) (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 59) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 74) (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 93) (:start . 80) (:id . 51))\n ((:tag . "JJ") (:stem . "3kb") (:form . "3kb") (:end . 97) (:start . 94)\n  (:id . 52))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 106)\n  (:start . 98) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 56))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 133)\n  (:start . 128) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 138) (:start . 134)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 142) (:start . 139)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 166) (:start . 150) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 171) (:start . 170)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 190) (:start . 177) (:id . 66))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 199)\n  (:start . 191) (:id . 67))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 206)\n  (:start . 200) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s920.5) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008615@unknown@formal@none@1@S@This 183-bp region was both cell type specific and responsive to two distinct stimuli, lipopolysaccharide and dibutyryl cAMP, known to regulate B7.1 expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "183-bp") (:form . "183-bp") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 105) (:start . 87) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 159)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s920.6) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008616@unknown@formal@none@1@S@Deletional and site-directed mutagenesis revealed the presence of multiple functionally critical cis elements within this region, one of which was a nuclear factor (NF)-kappaB consensus sequence.@(((:tag . "JJ") (:stem . "deletional") (:form . "Deletional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "site-directed") (:form . "site-directed")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 40)\n  (:start . 29) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 87)\n  (:start . 75) (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 96)\n  (:start . 88) (:id . 52))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 116)\n  (:start . 110) (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 128)\n  (:start . 122) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 194)\n  (:start . 186) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s920.7) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008617@unknown@formal@none@1@S@In B7.1-positive B cells, this element bound several members of the NF-kappaB family, transcription factors already implicated in signal transduction pathways relevant to B7.1 expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "b7.1-positive") (:form . "B7.1-positive")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 99) (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 167)\n  (:start . 159) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 175) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 186)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s920.8) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008618@unknown@formal@none@1@S@This is the first description, to our knowledge, of regulatory elements that control expression of a gene encoding a B7 costimulatory molecule.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "description") (:form . "description") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "b7") (:form . "B7") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 133) (:start . 120) (:id . 64))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 142)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s920.9) (:did . :|8642282|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008620@unknown@formal@none@1@S@A long period of clinical latency before development of symptoms is characteristic of human immunodeficiency virus type 1 (HIV-1) infection.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 82) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 108) (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s921.2) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008621@unknown@formal@none@1@S@OM10.1, a promyelocyte cell line latently infected with HIV-1, has been developed as a model for studying the mechanism of viral latency and the activation of virus expression.@(((:tag . "NNP") (:stem . "OM10.1") (:form . "OM10.1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 22)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s921.3) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008622@unknown@formal@none@1@S@We found that this latently infected cell line with heat shock at 42 degrees C for 2 h resulted in a high level of HIV-1 production without addition of any cytokines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "JJ") (:stem . "c") (:form . "C") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 105) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 111)\n  (:start . 106) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 120)\n  (:start . 115) (:id . 66))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 131)\n  (:start . 121) (:id . 67))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 139)\n  (:start . 132) (:id . 68))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 148)\n  (:start . 140) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 155) (:start . 152)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 165)\n  (:start . 156) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x921.4.1) (:span 132 139)))\n (:nscopes ((:id . :x921.4.1) (:span 132 165)))\n (:identifiers (:sid . :s921.4) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008623@unknown@formal@none@1@S@The mechanism of activation was analyzed by using anti-TNF-alpha antibody and various inhibitors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-tnf-alpha") (:form . "anti-TNF-alpha")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s921.5) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008624@unknown@formal@none@1@S@Although the TNF-alpha level in culture supernatants was below the sensitivity of an ELISA assay system, addition of anti-TNF-alpha antibody in culture medium could partially suppress the heat shock induced HIV-1 production.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "anti-tnf-alpha") (:form . "anti-TNF-alpha")\n  (:end . 131) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 174)\n  (:start . 165) (:id . 67))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 183)\n  (:start . 175) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 198)\n  (:start . 193) (:id . 71))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 206)\n  (:start . 199) (:id . 72))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 212)\n  (:start . 207) (:id . 73))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 223)\n  (:start . 213) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s921.6) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008625@unknown@formal@none@1@S@Staurosporine (PKC inhibitor), pentoxifylline (NF-kappa B inhibitor), and Ro5-3335 (HIV-1 Tat inhibitor) also inhibited significantly the heat shock induced virus activation.@(((:tag . "NNP") (:stem . "Staurosporine") (:form . "Staurosporine")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pentoxifylline") (:form . "pentoxifylline")\n  (:end . 45) (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ro5-3335") (:form . "Ro5-3335") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 103)\n  (:start . 94) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 119)\n  (:start . 110) (:id . 63))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 133) (:start . 120) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s921.7) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008626@unknown@formal@none@1@S@In particular, staurosporine achieved approximately 90% inhibition of the HIV-1 antigen expression in heat shock-treated OM10.1 at a non-toxic concentration.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "staurosporine") (:form . "staurosporine")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "achieve") (:form . "achieved") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 51) (:start . 38) (:id . 47))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "shock-treated") (:form . "shock-treated")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "om10.1") (:form . "OM10.1") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "non-toxic") (:form . "non-toxic") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 156) (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s921.8) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008627@unknown@formal@none@1@S@Although the mechanism of HIV-1 activation with heat shock has not been fully elucidated yet, it is presumed PKC plays an important role in HIV-1 activation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "presume") (:form . "presumed") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 131)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x921.9.1) (:span 63 66 78 88)))\n (:hscopes ((:id . :x921.9.1) (:span 9 92)))\n (:identifiers (:sid . :s921.9) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008628@unknown@formal@none@1@S@Thus, the present observations will provide a further insight into the pathogenesis of HIV-1 infections.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s921.10) (:did . :|8645086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008630@unknown@formal@none@1@S@Transcription factor NF-E2 is crucial for regulation of erythroid-specific gene expression.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 26) (:start . 21)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 74) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s922.2) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008631@unknown@formal@none@1@S@p45 subunit of NF-E2 contains a basic-leucine zipper domain and dimerizes with the small Maf family protein to form functional NF-E2 complex.@(((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "basic-leucine") (:form . "basic-leucine")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "zipper") (:form . "zipper") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "dimerize") (:form . "dimerizes") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Maf") (:form . "Maf") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s922.3) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008632@unknown@formal@none@1@S@While p45 expression was shown to be restricted to erythroid cells, megakaryocytes and mast cells in hematopoietic lineage, we found in this study that p45 mRNA is abundantly transcribed in the granulocyte fraction of human peripheral blood cells.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "megakaryocyte") (:form . "megakaryocytes")\n  (:end . 82) (:start . 68) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mast") (:form . "mast") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 114) (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 174)\n  (:start . 164) (:id . 71))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 186)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 205)\n  (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 223)\n  (:start . 218) (:id . 78))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 234)\n  (:start . 224) (:id . 79))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 240)\n  (:start . 235) (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 246)\n  (:start . 241) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s922.4) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008633@unknown@formal@none@1@S@As neutrophils occupy approximately 92% of the cells in granulocyte fraction of human peripheral blood cells.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "occupy") (:form . "occupy") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "CD") (:stem . "92") (:form . "92") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s922.5) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008634@unknown@formal@none@1@S@As neutrophils occupy approximately 92% of the cells in this fraction, the cells expressing p45 is most likely to be neutrophils.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "occupy") (:form . "occupy") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "CD") (:stem . "92") (:form . "92") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 128)\n  (:start . 117) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x922.6.1) (:span 104 110)))\n (:hscopes ((:id . :x922.6.1) (:span 71 128)))\n (:identifiers (:sid . :s922.6) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008635@unknown@formal@none@1@S@p45 mRNA is also expressed in HL-60 promyelocytes, albeit the expression level is much lower than that of the granulocyte fraction.@(((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "promyelocyte") (:form . "promyelocytes")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "albeit") (:form . "albeit") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 121)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s922.7) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008636@unknown@formal@none@1@S@HL-60 cells were found to express mafK mRNA, indicating the presence of genuine NF-E2 complex in the cells.@(((:tag . "NNP") (:stem . "HL-60") (:form . "HL-60") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "mafk") (:form . "mafK") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "genuine") (:form . "genuine") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s922.8) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008637@unknown@formal@none@1@S@Although p45 mRNA is transcribed from two different promoters, aNF-E2 promoter and fNF-E2 promoter, in erythroid and megakaryocytic lineage cells, p45 mRNA is transcribed only from aNF-E2 promoter.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "anf-e2") (:form . "aNF-E2") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fnf-e2") (:form . "fNF-E2") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 131) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 170)\n  (:start . 159) (:id . 68))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "anf-e2") (:form . "aNF-E2") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 196)\n  (:start . 188) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s922.9) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008638@unknown@formal@none@1@S@The expression of p45 megakaryocytic lineage cells, p45 mRNA is transcribed only from aNF-E2 promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "megakaryocytic") (:form . "megakaryocytic")\n  (:end . 36) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p45") (:form . "p45") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 75)\n  (:start . 64) (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "anf-e2") (:form . "aNF-E2") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s922.10) (:did . :|8645254|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008640@unknown@formal@none@1@S@Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s923.1) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008641@unknown@formal@none@1@S@Regulation of the transcription factor NF-kappaB involves proteasome-mediated processing of the NF-kappaB1 p105 precursor protein, which generates the p50 subunit of NF-kappaB.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "JJ") (:stem . "proteasome-mediated")\n  (:form . "proteasome-mediated") (:end . 77) (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 88)\n  (:start . 78) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nf-kappab1") (:form . "NF-kappaB1") (:end . 106)\n  (:start . 96) (:id . 53))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 111) (:start . 107)\n  (:id . 54))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 121)\n  (:start . 112) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 58))\n ((:tag . "VBZ") (:stem . "generate") (:form . "generates") (:end . 146)\n  (:start . 137) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 154) (:start . 151)\n  (:id . 61))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 162)\n  (:start . 155) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 175)\n  (:start . 166) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s923.2) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008642@unknown@formal@none@1@S@The processing of p105 occurs constitutively in vivo but can be markedly enhanced by various cellular activation agents, although the underlying regulatory mechanism is not yet clear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 44) (:start . 30) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "underlying") (:form . "underlying") (:end . 144)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 165)\n  (:start . 156) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x923.3.1) (:span 169 172 177 182)))\n (:hscopes ((:id . :x923.3.1) (:span 130 182)))\n (:identifiers (:sid . :s923.3) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008643@unknown@formal@none@1@S@In the present study, we demonstrate that signal-mediated induction of p105 processing in human T cells is associated with de novo synthesis of this precursor protein.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "signal-mediated") (:form . "signal-mediated")\n  (:end . 57) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 166)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s923.4) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008644@unknown@formal@none@1@S@Transient transfection studies performed in COS7 cells revealed that the newly synthesized p105 protein appears to be more rapidly processed compared to its accumulated form that is already associated with the processed product p50.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cos7") (:form . "COS7") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "synthesize") (:form . "synthesized") (:end . 90)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "VBD") (:stem . "process") (:form . "processed") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "accumulated") (:form . "accumulated") (:end . 168)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 173) (:start . 169)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 189)\n  (:start . 182) (:id . 69))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 200)\n  (:start . 190) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 205) (:start . 201)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "process") (:form . "processed") (:end . 219)\n  (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 227)\n  (:start . 220) (:id . 74))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 231) (:start . 228)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x923.5.1) (:span 104 111)))\n (:hscopes ((:id . :x923.5.1) (:span 69 231)))\n (:identifiers (:sid . :s923.5) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008645@unknown@formal@none@1@S@Interestingly, the processing rate of p105 is markedly inhibited in cells co-transfected with p50 or other NF-kappaB subunits, including RelA and c-Rel, that physically interact with p105.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "co-transfecte") (:form . "co-transfected")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 168)\n  (:start . 158) (:id . 68))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 182) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 187) (:start . 183)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s923.6) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008646@unknown@formal@none@1@S@These findings suggest that the processing of p105 is subject to negative regulation by the various NF-kappaB subunits.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "subject") (:form . "subject") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x923.7.1) (:span 15 22)))\n (:hscopes ((:id . :x923.7.1) (:span 15 118)))\n (:identifiers (:sid . :s923.7) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008647@unknown@formal@none@1@S@We further demonstrate that p105 undergoes degradation in lipopolysaccharide-stimulated human monocytic cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "undergo") (:form . "undergoes") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 87) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 103)\n  (:start . 94) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s923.8) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008648@unknown@formal@none@1@S@However, the inducible degradation of p105 is not coupled with the generation of p50.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x923.9.1) (:span 46 49)))\n (:nscopes ((:id . :x923.9.1) (:span 46 84)))\n (:identifiers (:sid . :s923.9) (:did . :|8649779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008650@unknown@formal@none@1@S@Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LIM-Hox") (:form . "LIM-Hox") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "aberrantly") (:form . "aberrantly") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "myelogenous") (:form . "myelogenous") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "CD") (:stem . "9q33-34.1") (:form . "9q33-34.1") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s924.1) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008651@unknown@formal@none@1@S@We describe the isolation of human LH-2, a putative transcription factor containing two cysteine-rich regions (LIM domains) and a homeobox (Hox) DNA-binding domain.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lh-2") (:form . "LH-2") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LIM") (:form . "LIM") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "homeobox") (:form . "homeobox") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Hox") (:form . "Hox") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 156)\n  (:start . 145) (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 163)\n  (:start . 157) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s924.2) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008652@unknown@formal@none@1@S@High levels of hLH-2 expression were observed in all cases of chronic myelogenous leukaemia (CML) tested, regardless of disease status.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "myelogenous") (:form . "myelogenous") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s924.3) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008653@unknown@formal@none@1@S@hLH-2 was mapped to chromosome 9Q33-34.1, in the same region as the reciprocal translocation that creates the BCR-ABL chimera of the Philadelphia chromosome (Ph'), the hallmark of CML; hLH-2 was retained on the derivative 9 chromosome and is therefore centromeric of c-ABL.@(((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 16) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "9q33-34.1") (:form . "9Q33-34.1") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . 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5008654@unknown@formal@none@1@S@The proximity of hLH-2 to the breakpoint on chromosome 9 raises the possibility of cis-activation by the t(9;22)(q34;q11) translocation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proximity") (:form . "proximity") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "breakpoint") (:form . "breakpoint") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cis-activation") (:form . "cis-activation")\n  (:end . 97) (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "t(9;22)(q34;q11)") (:form . "t(9;22)(q34;q11)")\n  (:end . 121) (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x924.5.1) (:span 57 79)))\n (:hscopes ((:id . :x924.5.1) (:span 57 135)))\n (:identifiers (:sid . :s924.5) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008655@unknown@formal@none@1@S@In addition to finding hLH-2 expression in all cases of CML, expression was observed in lymphoid malignancies and myeloid cell lines, but not in primary cases of acute myelogenous leukaemia.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "malignancy") (:form . "malignancies") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 158)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 167)\n  (:start . 162) (:id . 71))\n ((:tag . "JJ") (:stem . "myelogenous") (:form . "myelogenous") (:end . 179)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x924.6.1) (:span 138 141)))\n (:nscopes ((:id . :x924.6.1) (:span 138 189)))\n (:identifiers (:sid . :s924.6) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008656@unknown@formal@none@1@S@The role of hLH-2 in the development or progression of leukaemia is not known.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 51)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "leukaemia") (:form . "leukaemia") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x924.7.1) (:span 68 77)))\n (:hscopes ((:id . :x924.7.1) (:span 0 77)))\n (:identifiers (:sid . :s924.7) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008657@unknown@formal@none@1@S@However, hLH-2 may prove useful as a marker of CML for monitoring residual disease.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "hlh-2") (:form . "hLH-2") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "monitor") (:form . "monitoring") (:end . 65)\n  (:start . 55) (:id . 54))\n ((:tag . "JJ") (:stem . "residual") (:form . "residual") (:end . 74)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x924.8.1) (:span 15 18)))\n (:hscopes ((:id . :x924.8.1) (:span 15 82)))\n (:identifiers (:sid . :s924.8) (:did . :|8649822|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008658@unknown@formal@none@1@S@BCL-6 expression during B-cell activation.@(((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s925.1) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008660@unknown@formal@none@1@S@Invariably, the BCL-6 coding region is intact, but its 5' untranslated region is replaced with sequences from the translocation partner.@(((:tag . "RB") (:stem . "invariably") (:form . "Invariably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "untranslated") (:form . "untranslated") (:end . 70)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 104)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 127) (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s925.3) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008661@unknown@formal@none@1@S@The present study shows that BCL-6 expression is regulated in lymphocytes during mitogenic stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s925.4) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008662@unknown@formal@none@1@S@Resting B and T lymphocytes contain high levels of BCL-6 mRNA.@(((:tag . "VBG") (:stem . "rest") (:form . "Resting") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s925.5) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008663@unknown@formal@none@1@S@Stimulation of mouse B cells with anti-IgM or IgD antibodies, bacterial lipopolysaccharide, phorbol 12-myristate 13-acetate plus ionomycin, or CD40 ligand led to a five-fold to 35-fold decrease in BCL-6 mRNA levels.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-igm") (:form . "anti-IgM") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IgD") (:form . "IgD") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 90) (:start . 72) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 112)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 128) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 154)\n  (:start . 148) (:id . 64))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 173)\n  (:start . 164) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "35-fold") (:form . "35-fold") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 214)\n  (:start . 208) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s925.6) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008664@unknown@formal@none@1@S@Similar downregulation of BCL-6 mRNA was seen in human B cells stimulated with Staphylococcus aureus plus interleukin-2 or anti-IgM antibodies and in human T lymphocytes stimulated with phytohemagglutinin.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 22) (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "FW") (:stem . "staphylococcus") (:form . "Staphylococcus")\n  (:end . 93) (:start . 79) (:id . 55))\n ((:tag . "FW") (:stem . "aureus") (:form . "aureus") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 119) (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-igm") (:form . "anti-IgM") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 169)\n  (:start . 158) (:id . 66))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 204) (:start . 186) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s925.7) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008665@unknown@formal@none@1@S@BCL-6 mRNA levels began to decrease 8 to 16 hours after stimulation, before cells entered S phase.@(((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "begin") (:form . "began") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "enter") (:form . "entered") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s925.8) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008666@unknown@formal@none@1@S@Although polyclonal activation of B cells in vitro invariably decreased BCL-6 MRNA expression, activated B cells from human germinal centers expressed BCL-6 mRNA at levels comparable to the levels in resting B cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "invariably") (:form . "invariably") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MRNA") (:form . "MRNA") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "center") (:form . "centers") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 156)\n  (:start . 151) (:id . 64))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 171)\n  (:start . 165) (:id . 67))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 182)\n  (:start . 172) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 196)\n  (:start . 190) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 207)\n  (:start . 200) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 209) (:start . 208)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s925.9) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008667@unknown@formal@none@1@S@Despite these similar mRNA levels, BCL-6 protein expression was threefold to 34-fold higher in germinal center B cells than in resting B cells, suggesting that BCL-6 protein levels are controlled by translational or posttranslational mechanisms.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BCL-6") (:form . "BCL-6") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "threefold") (:form . "threefold") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "RB") (:stem . "34-fold") (:form . "34-fold") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 91) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 154)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 173)\n  (:start . 166) (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 180)\n  (:start . 174) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 195)\n  (:start . 185) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 212) (:start . 199) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "posttranslational") (:form . "posttranslational")\n  (:end . 233) (:start . 216) (:id . 77))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 244)\n  (:start . 234) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x925.10.1) (:span 144 154)))\n (:hscopes ((:id . :x925.10.1) (:span 144 244)))\n (:identifiers (:sid . :s925.10) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008668@unknown@formal@none@1@S@These observations suggest that the germinal center reaction provides unique activation signals to B cells that allow for continued, high-level BCL-6 expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "allow") (:form . "allow") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "continued") (:form . "continued") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "bcl-6") (:form . "BCL-6") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 160)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x925.11.1) (:span 19 26)))\n (:hscopes ((:id . :x925.11.1) (:span 19 160)))\n (:identifiers (:sid . :s925.11) (:did . :|8652841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008670@unknown@formal@none@1@S@We have previously shown that a DNA-binding factor specific to adult hematopoietic cells (polypryrimidine-binding factor, PYBF) binds to a pyrimidine-rich region 1 kb upstream from the human delta-globin-encoding gene (HBD).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "polypryrimidine-binding")\n  (:form . "polypryrimidine-binding") (:end . 113) (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 120)\n  (:start . 114) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PYBF") (:form . "PYBF") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "pyrimidine-rich") (:form . "pyrimidine-rich")\n  (:end . 154) (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 175)\n  (:start . 167) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . "JJ") (:stem . "delta-globin-encoding")\n  (:form . "delta-globin-encoding") (:end . 212) (:start . 191) (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 217) (:start . 213)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HBD") (:form . "HBD") (:end . 222) (:start . 219)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s926.2) (:did . :|8654951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008671@unknown@formal@none@1@S@The developmental stage-specificity of PYBF and the location of its binding site between the fetal and adult beta-globin (HBB)-like genes suggest that PBYF and its binding site may function in fetal-to-adult globin gene switching.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "stage-specificity") (:form . "stage-specificity")\n  (:end . 35) (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PYBF") (:form . "PYBF") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "HBB)-like") (:form . "HBB)-like") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PBYF") (:form . "PBYF") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 176) (:start . 172)\n  (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "fetal-to-adult") (:form . "fetal-to-adult")\n  (:end . 207) (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 214)\n  (:start . 208) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 219) (:start . 215)\n  (:id . 75))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 229)\n  (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x926.3.1) (:span 177 180))\n  ((:id . :x926.3.2) (:span 138 145)))\n (:hscopes ((:id . :x926.3.1) (:span 177 229))\n  ((:id . :x926.3.2) (:span 138 229)))\n (:identifiers (:sid . :s926.3) (:did . :|8654951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008672@unknown@formal@none@1@S@Here, we describe the effect of 383-bp (delta383) and 99-bp (delta99) sequences containing the PYBF-binding site on transcription from various globin and non-globin promoters, using a transient assay with the cat reporter gene in murine erythroleukemia (MEL) cells, a cell line with abundant PYBF activity.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "383-bp") (:form . "383-bp") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "delta383") (:form . "delta383") (:end . 48)\n  (:start . 40) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "99-bp") (:form . "99-bp") (:end . 59) (:start . 54)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "delta99") (:form . "delta99") (:end . 68)\n  (:start . 61) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 79)\n  (:start . 70) (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 90)\n  (:start . 80) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pybf-binding") (:form . "PYBF-binding") (:end . 107)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 129) (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "non-globin") (:form . "non-globin") (:end . 164)\n  (:start . 154) (:id . 69))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 174)\n  (:start . 165) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 181) (:start . 176)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 199)\n  (:start . 194) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 204) (:start . 200)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cat") (:form . "cat") (:end . 212) (:start . 209)\n  (:id . 78))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 221)\n  (:start . 213) (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 226) (:start . 222)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 236)\n  (:start . 230) (:id . 82))\n ((:tag . "NN") (:stem . "erythroleukemia") (:form . "erythroleukemia")\n  (:end . 252) (:start . 237) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 254) (:start . 253)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "MEL") (:form . "MEL") (:end . 257) (:start . 254)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 258) (:start . 257)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 264)\n  (:start . 259) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 265) (:start . 264)\n  (:id . 88))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 267) (:start . 266)\n  (:id . 89))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 272) (:start . 268)\n  (:id . 90))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 277) (:start . 273)\n  (:id . 91))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 282) (:start . 278)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 291)\n  (:start . 283) (:id . 93))\n ((:tag . "NNP") (:stem . "PYBF") (:form . "PYBF") (:end . 296) (:start . 292)\n  (:id . 94))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 305)\n  (:start . 297) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s926.4) (:did . :|8654951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008673@unknown@formal@none@1@S@We show that both delta383 and delta99 specifically enhance expression of cat for plasmids containing a human adult globin (HBB) promoter, whereas expression of similar constructs using human fetal (A gamma-) globin (HBG1) or simian virus 40 (SV40) promoters is not enhanced.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "delta383") (:form . "delta383") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "delta99") (:form . "delta99") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cat") (:form . "cat") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HBB") (:form . "HBB") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 157)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 185) (:start . 180)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 191)\n  (:start . 186) (:id . 72))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gamma-") (:form . "gamma-") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 77))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 215)\n  (:start . 209) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 217) (:start . 216)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "HBG1") (:form . "HBG1") (:end . 221) (:start . 217)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 81))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 225) (:start . 223)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 232)\n  (:start . 226) (:id . 83))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 238)\n  (:start . 233) (:id . 84))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 241) (:start . 239)\n  (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 243) (:start . 242)\n  (:id . 86))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 247) (:start . 243)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 258)\n  (:start . 249) (:id . 89))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 261) (:start . 259)\n  (:id . 90))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 265) (:start . 262)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 274)\n  (:start . 266) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x926.5.1) (:span 223 225)))\n (:ncues ((:id . :x926.5.2) (:span 262 265)))\n (:hscopes ((:id . :x926.5.1) (:span 186 232)))\n (:nscopes ((:id . :x926.5.2) (:span 147 274)))\n (:identifiers (:sid . :s926.5) (:did . :|8654951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008674@unknown@formal@none@1@S@The results suggest that PYBF and the pyrimidine-rich region upstream from HBD can specifically enhance HBB transcription in adult erythroid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PYBF") (:form . "PYBF") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pyrimidine-rich") (:form . "pyrimidine-rich")\n  (:end . 53) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HBD") (:form . "HBD") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 95)\n  (:start . 83) (:id . 55))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "NNP") (:stem . "HBB") (:form . "HBB") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 140)\n  (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x926.6.1) (:span 12 19)))\n (:hscopes ((:id . :x926.6.1) (:span 12 146)))\n (:identifiers (:sid . :s926.6) (:did . :|8654951|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008675@unknown@formal@none@1@S@A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ICSAT/Pip/LSIRF") (:form . "ICSAT/Pip/LSIRF")\n  (:end . 81) (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 98)\n  (:start . 88) (:id . 54))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "interferon-regulated")\n  (:form . "interferon-regulated") (:end . 145) (:start . 125) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 151)\n  (:start . 146) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s927.1) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008676@unknown@formal@none@1@S@We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "sequence-binding") (:form . "sequence-binding")\n  (:end . 88) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 166) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 174)\n  (:start . 167) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 187)\n  (:start . 182) (:id . 75))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 195)\n  (:start . 188) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 78))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 211)\n  (:start . 203) (:id . 79))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 218)\n  (:start . 212) (:id . 80))\n ((:tag . "NNP") (:stem . "Pip/LSIRF") (:form . "Pip/LSIRF") (:end . 228)\n  (:start . 219) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s927.2) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008677@unknown@formal@none@1@S@ICSAT is structurally most closely related to the previously cloned ICSBP, a member of the IFN regulatory factor (IRF) family of proteins that binds to interferon consensus sequences (ICSs) found in many promoters of the IFN-regulated genes.@(((:tag . "NN") (:stem . "icsat") (:form . "ICSAT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "ICSBP") (:form . "ICSBP") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IRF") (:form . "IRF") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 162)\n  (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "ICS") (:form . "ICSs") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 195)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 203) (:start . 199)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 213)\n  (:start . 204) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "ifn-regulated") (:form . "IFN-regulated")\n  (:end . 234) (:start . 221) (:id . 82))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 240)\n  (:start . 235) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s927.3) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008678@unknown@formal@none@1@S@Among T-cell lines investigated, ICSAT was abundantly expressed in human T-cell leukemia virus type 1 (HTLV-1)-infected T cells.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "HTLV-1)-infected") (:form . "HTLV-1)-infected")\n  (:end . 119) (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s927.4) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008680@unknown@formal@none@1@S@When the binding of ICSAT to four different ICSs was tested, the relative differences in binding affinities for those ICSs were determined.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "ics") (:form . "ICSs") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 59) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 85)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "ics") (:form . "ICSs") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s927.6) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008681@unknown@formal@none@1@S@To study the functional role of ICSAT, we performed cotransfection experiments with the human embryonal carcinoma cell line N-Tera2.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 66) (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "embryonal") (:form . "embryonal") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "n-tera2") (:form . "N-Tera2") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s927.7) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008682@unknown@formal@none@1@S@ICSAT was demonstrated to possess repressive function over the gene activation induced by IFN stimulation or by IRF-1 cotransfection.@(((:tag . "NN") (:stem . "icsat") (:form . "ICSAT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VB") (:stem . "possess") (:form . "possess") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 132) (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s927.8) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008683@unknown@formal@none@1@S@Such repressive function is similar to that seen in IRF-2 or ICSBP.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IRF-2") (:form . "IRF-2") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ICSBP") (:form . "ICSBP") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s927.9) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008684@unknown@formal@none@1@S@However, we have found that ICSAT has a different repressive effect from that of IRF-2 or ICSBP in some IFN-responsive reporter constructs.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ICSAT") (:form . "ICSAT") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 49)\n  (:start . 40) (:id . 51))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IRF-2") (:form . "IRF-2") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "ICSBP") (:form . "ICSBP") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ifn-responsive") (:form . "IFN-responsive")\n  (:end . 118) (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s927.10) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008685@unknown@formal@none@1@S@These results suggest that a novel mechanism of gene regulation by "differential repression" is used by multiple members of repressor proteins with different repressive effects on the IFN-responsive genes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "\\"differential") (:form . "\\"differential")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 168)\n  (:start . 158) (:id . 66))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "ifn-responsive") (:form . "IFN-responsive")\n  (:end . 198) (:start . 184) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 204)\n  (:start . 199) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x927.11.1) (:span 14 21)))\n (:hscopes ((:id . :x927.11.1) (:span 14 204)))\n (:identifiers (:sid . :s927.11) (:did . :|8657101|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008686@unknown@formal@none@1@S@DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "triplex") (:form . "triplex") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 65) (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 84) (:start . 66) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 91)\n  (:start . 85) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s928.1) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008687@unknown@formal@none@1@S@Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 41) (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 56)\n  (:start . 50) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 74)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 153)\n  (:start . 142) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 170)\n  (:start . 159) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s928.2) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008688@unknown@formal@none@1@S@Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 15)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "hemopoiesis") (:form . "hemopoiesis") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 86) (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 136)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 190)\n  (:start . 183) (:id . 71))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 203)\n  (:start . 191) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x928.3.2) (:span 25 31)))\n (:ncues ((:id . :x928.3.1) (:span 21 24)))\n (:hscopes ((:id . :x928.3.2) (:span 9 70)))\n (:nscopes ((:id . :x928.3.1) (:span 9 70)))\n (:identifiers (:sid . :s928.3) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008690@unknown@formal@none@1@S@We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "oligonucleotide-directed")\n  (:form . "oligonucleotide-directed") (:end . 40) (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "triple") (:form . "triple") (:end . 47)\n  (:start . 41) (:id . 45))\n ((:tag . "NN") (:stem . "helix") (:form . "helix") (:end . 53) (:start . 48)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 63)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 70)\n  (:start . 64) (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 75) (:start . 71)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 86)\n  (:start . 76) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 95)\n  (:start . 87) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 110)\n  (:start . 101) (:id . 54))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 115) (:start . 111)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 56))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 126)\n  (:start . 119) (:id . 57))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 133)\n  (:start . 127) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x928.5.1) (:span 101 110)))\n (:hscopes ((:id . :x928.5.1) (:span 101 152)))\n (:identifiers (:sid . :s928.5) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008691@unknown@formal@none@1@S@A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "15-base") (:form . "15-base") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GM3") (:form . "GM3") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "VBZ") (:stem . "overlap") (:form . "overlaps") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s928.6) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008692@unknown@formal@none@1@S@Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dnase") (:form . "DNase") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GM3") (:form . "GM3") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 79) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 99) (:start . 82) (:id . 55))\n ((:tag . "JJ") (:stem . "collinear") (:form . "collinear") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "triplex") (:form . "triplex") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 142) (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 146) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 153)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s928.7) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008693@unknown@formal@none@1@S@Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.@(((:tag . "NN") (:stem . "triplex") (:form . "Triplex") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GM3") (:form . "GM3") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s928.8) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008694@unknown@formal@none@1@S@GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.@(((:tag . "NNP") (:stem . "GM3") (:form . "GM3") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "lymphotrophic") (:form . "lymphotrophic")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "virus-1") (:form . "virus-1") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transactivator-induced")\n  (:form . "transactivator-induced") (:end . 105) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 116)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 58))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 141)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 151)\n  (:start . 142) (:id . 60))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 158)\n  (:start . 152) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 172)\n  (:start . 166) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 181)\n  (:start . 173) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 191)\n  (:start . 185) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 193) (:start . 192)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s928.9) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008695@unknown@formal@none@1@S@Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "GM3") (:form . "GM3") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 138)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 150)\n  (:start . 139) (:id . 65))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x928.10.1) (:span 128 131)))\n (:nscopes ((:id . :x928.10.1) (:span 128 182)))\n (:identifiers (:sid . :s928.10) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008696@unknown@formal@none@1@S@We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 102) (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s928.11) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008697@unknown@formal@none@1@S@Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.@(((:tag . "JJ") (:stem . "colinear") (:form . "Colinear") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "triplex") (:form . "triplex") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 126)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "application") (:form . "application") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "undesirable") (:form . "undesirable") (:end . 162)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 177) (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 185) (:start . 181)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 193)\n  (:start . 186) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x928.12.1) (:span 105 114))\n  ((:id . :x928.12.2) (:span 96 99)))\n (:hscopes ((:id . :x928.12.1) (:span 105 193))\n  ((:id . :x928.12.2) (:span 96 193)))\n (:identifiers (:sid . :s928.12) (:did . :|8662666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008698@unknown@formal@none@1@S@Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements.@(((:tag . "NNS") (:stem . "receptor") (:form . "Receptors") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL)-10") (:form . "IL)-10") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-6-type") (:form . "IL-6-type") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 117) (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 139)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 148)\n  (:start . 140) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s929.1) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008700@unknown@formal@none@1@S@To determine whether the IL-10R has signaling functions similar to IL-6R in cells normally expressing these receptors, leukocytes of the B-, T-, and NK-cell lineages were treated with either cytokine.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-6r") (:form . "IL-6R") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "b-") (:form . "B-") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t-") (:form . "T-") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "nk-cell") (:form . "NK-cell") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 165)\n  (:start . 157) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 72))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 190)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 199)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x929.3.1) (:span 13 20)))\n (:hscopes ((:id . :x929.3.1) (:span 13 117)))\n (:identifiers (:sid . :s929.3) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008701@unknown@formal@none@1@S@Both cytokines activated factors that bound to the sis-inducible element and included STAT1 and STAT3.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sis-inducible") (:form . "sis-inducible")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 101)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s929.4) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008702@unknown@formal@none@1@S@The cell response to IL-10 characteristically differed from that to IL-2/IL-15, IL-4, and interferon gamma.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "characteristically") (:form . "characteristically")\n  (:end . 45) (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-2/IL-15") (:form . "IL-2/IL-15") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s929.5) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008703@unknown@formal@none@1@S@The signaling capabilities of the IL-10R for activating specific STAT proteins and inducing gene transcription were defined by reconstitution of receptor functions in transfected tissue culture cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "capability") (:form . "capabilities") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "reconstitution") (:form . "reconstitution")\n  (:end . 141) (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 163)\n  (:start . 154) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 178)\n  (:start . 167) (:id . 65))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 185)\n  (:start . 179) (:id . 66))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 193)\n  (:start . 186) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s929.6) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008704@unknown@formal@none@1@S@COS-1 cells, co-expressing the human IL-10R and individual STAT proteins, confirmed a preference of the IL-10R for STAT3 and STAT1.@(((:tag . "NN") (:stem . "cos-1") (:form . "COS-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "co-expresse") (:form . "co-expressing") (:end . 26)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "preference") (:form . "preference") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s929.7) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008705@unknown@formal@none@1@S@Unlike many hematopoietin receptors, the IL-10R did not detectably activate STAT5.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hematopoietin") (:form . "hematopoietin")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "detectably") (:form . "detectably") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x929.8.1) (:span 52 55)))\n (:nscopes ((:id . :x929.8.1) (:span 52 81)))\n (:identifiers (:sid . :s929.8) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008706@unknown@formal@none@1@S@The IL-10R, together with reporter gene constructs containing different IL-6-responsive gene elements, reconstituted in hepatoma cells an induction of transcription by IL-10 that was comparable to that by IL-6.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "il-6-responsive") (:form . "IL-6-responsive")\n  (:end . 87) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 116) (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hepatoma") (:form . "hepatoma") (:end . 128)\n  (:start . 120) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 147)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 164) (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 173)\n  (:start . 168) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 178) (:start . 174)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 193)\n  (:start . 183) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 196) (:start . 194)\n  (:id . 69))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 201) (:start . 197)\n  (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 209) (:start . 205)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s929.9) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008707@unknown@formal@none@1@S@This regulation could not be appreciably modified by enhanced expression of STAT proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "appreciably") (:form . "appreciably") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x929.10.1) (:span 22 25)))\n (:nscopes ((:id . :x929.10.1) (:span 0 89)))\n (:identifiers (:sid . :s929.10) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008708@unknown@formal@none@1@S@The similar actions of IL-10R and IL-6R on the induction of endogenous IL-6-responsive genes were demonstrated in hepatoma cells stably expressing the IL-10R.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-10R") (:form . "IL-10R") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-6R") (:form . "IL-6R") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "il-6-responsive") (:form . "IL-6-responsive")\n  (:end . 86) (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 110)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hepatoma") (:form . "hepatoma") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s929.11) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008710@unknown@formal@none@1@S@The data demonstrate that the IL-10R, unlike other members of the interferon receptor family, is highly effective in recruiting the signaling pathways of IL-6-type cytokine receptors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-10r") (:form . "IL-10R") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "recruit") (:form . "recruiting") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "il-6-type") (:form . "IL-6-type") (:end . 163)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 172)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 182)\n  (:start . 173) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s929.13) (:did . :|8662928|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008711@unknown@formal@none@1@S@Globin gene switching.@(((:tag . "NNP") (:stem . "Globin") (:form . "Globin") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 22) (:start . 21)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s930.1) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008712@unknown@formal@none@1@S@In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s930.2) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008713@unknown@formal@none@1@S@To characterize the protein-DNA interactions important for the developmental control of the human beta-globin locus, we analyzed by in vivo dimethyl sulfate footprinting erythroid cells expressing either the fetal or the adult globin developmental program.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 76) (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 109)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dimethyl") (:form . "dimethyl") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "sulfate") (:form . "sulfate") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 169)\n  (:start . 157) (:id . 65))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 179)\n  (:start . 170) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 67))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 196)\n  (:start . 186) (:id . 68))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 203)\n  (:start . 197) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 213)\n  (:start . 208) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 216) (:start . 214)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 226)\n  (:start . 221) (:id . 74))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 233)\n  (:start . 227) (:id . 75))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 247) (:start . 234) (:id . 76))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 255)\n  (:start . 248) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s930.3) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008714@unknown@formal@none@1@S@In the locus control region (LCR) of the beta-globin locus, in vivo footprints on NF-E2 (or AP-1) and GATA-1 motifs remained the same regardless of whether the fetal or the adult globin genes are expressed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LCR") (:form . "LCR") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 52)\n  (:start . 41) (:id . 52))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 67) (:start . 63)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "footprint") (:form . "footprints") (:end . 78)\n  (:start . 68) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nf-e2") (:form . "NF-E2") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 96) (:start . 92)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 108)\n  (:start . 102) (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 115)\n  (:start . 109) (:id . 66))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 124)\n  (:start . 116) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 133) (:start . 129)\n  (:id . 69))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 144)\n  (:start . 134) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 71))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 155)\n  (:start . 148) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 165)\n  (:start . 160) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 168) (:start . 166)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 178)\n  (:start . 173) (:id . 77))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 185)\n  (:start . 179) (:id . 78))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 191)\n  (:start . 186) (:id . 79))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 195) (:start . 192)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 205)\n  (:start . 196) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x930.4.1) (:span 166 168))\n  ((:id . :x930.4.2) (:span 148 155)))\n (:hscopes ((:id . :x930.4.1) (:span 156 191))\n  ((:id . :x930.4.2) (:span 148 205)))\n (:identifiers (:sid . :s930.4) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008715@unknown@formal@none@1@S@In contrast, in vivo footprints on GT (CACCC) motifs differed between the cells expressing the fetal or the adult globin program.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "footprint") (:form . "footprints") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GT") (:form . "GT") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CACCC") (:form . "CACCC") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 61)\n  (:start . 53) (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 69)\n  (:start . 62) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 90)\n  (:start . 80) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 120)\n  (:start . 114) (:id . 64))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s930.5) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008716@unknown@formal@none@1@S@In promoter regions, the actively transcribed genes demonstrated extensive and consistent footprints over the canonical elements, such as CACCC and CCAAT motifs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "footprint") (:form . "footprints") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 128)\n  (:start . 120) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CACCC") (:form . "CACCC") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CCAAT") (:form . "CCAAT") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s930.6) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008717@unknown@formal@none@1@S@The adult globin expressing cells displayed more extensive footprints than the fetal globin expressing cells in the 3' regulatory sequences of both the Agamma- and the beta-globin genes, suggesting a role of these 3' elements in beta-globin gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "expressing") (:form . "expressing") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "footprint") (:form . "footprints") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "expressing") (:form . "expressing") (:end . 102)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 129)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "agamma-") (:form . "Agamma-") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 179)\n  (:start . 168) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 197)\n  (:start . 187) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 225)\n  (:start . 217) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 80))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 240)\n  (:start . 229) (:id . 81))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 245) (:start . 241)\n  (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 256)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x930.7.1) (:span 187 197)))\n (:hscopes ((:id . :x930.7.1) (:span 187 256)))\n (:identifiers (:sid . :s930.7) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008718@unknown@formal@none@1@S@Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta-globin gene promoters, and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression, perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "bulk") (:form . 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"promoters") (:end . 175)\n  (:start . 166) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gt") (:form . "GT") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 195)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 214)\n  (:start . 203) (:id . 75))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 220)\n  (:start . 215) (:id . 76))\n ((:tag . "NNP") (:stem . "LCR") (:form . 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"human") (:end . 281)\n  (:start . 276) (:id . 87))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 293)\n  (:start . 282) (:id . 88))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 298) (:start . 294)\n  (:id . 89))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 309)\n  (:start . 299) (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 310) (:start . 309)\n  (:id . 91))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 318)\n  (:start . 311) (:id . 92))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 321) (:start . 319)\n  (:id . 93))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 332)\n  (:start . 322) (:id . 94))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 336) (:start . 333)\n  (:id . 95))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 348)\n  (:start . 337) (:id . 96))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 351) (:start . 349)\n  (:id . 97))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 363)\n  (:start . 352) (:id . 98))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 366) (:start . 364)\n  (:id . 99))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 370) (:start . 367)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "LCR") (:form . "LCR") (:end . 374) (:start . 371)\n  (:id . 101))\n ((:tag . "NN") (:stem . "holocomplex") (:form . "holocomplex") (:end . 386)\n  (:start . 375) (:id . 102))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 391) (:start . 387)\n  (:id . 103))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 395) (:start . 392)\n  (:id . 104))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 401)\n  (:start . 396) (:id . 105))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 404) (:start . 402)\n  (:id . 106))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 408) (:start . 405)\n  (:id . 107))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 414)\n  (:start . 409) (:id . 108))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 421)\n  (:start . 415) (:id . 109))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 426) (:start . 422)\n  (:id . 110))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 427) (:start . 426)\n  (:id . 111)))@@@1@70@((:hcues ((:id . :x930.8.1) (:span 311 318))\n  ((:id . :x930.8.2) (:span 225 228)) ((:id . :x930.8.3) (:span 12 19)))\n (:hscopes ((:id . :x930.8.1) (:span 311 426))\n  ((:id . :x930.8.2) (:span 225 426)) ((:id . :x930.8.3) (:span 12 426)))\n (:identifiers (:sid . :s930.8) (:did . :|8662960|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008720@unknown@formal@none@1@S@PU.1 (spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid and B cells, activates many B cell and myeloid genes, and is critical for development of both of these lineages.@(((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "spi-1") (:form . "spi-1") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 47))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 22)\n  (:start . 16) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 33) (:start . 30)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 54)\n  (:start . 48) (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 61)\n  (:start . 55) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 56))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 79) (:start . 66) (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 89)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 100)\n  (:start . 93) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 123)\n  (:start . 114) (:id . 65))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 147)\n  (:start . 140) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 153)\n  (:start . 148) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 170)\n  (:start . 162) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 174) (:start . 171)\n  (:id . 76))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 186)\n  (:start . 175) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 78))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 194) (:start . 190)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 80))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 203)\n  (:start . 198) (:id . 81))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 212)\n  (:start . 204) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s931.2) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008721@unknown@formal@none@1@S@Our previous studies (Chen, H.M., Ray-Gallet, D., Zhang, P., Hetherington, C.J., Gonzalez, D.A., Zhang, D.-E., Moreau-Gachelin, F., and Tenen, D.G.(1995) Oncogene 11, 1549-1560) demonstrate that the PU.1 promoter directs cell type-specific reporter gene expression in myeloid cell lines, and that PU.1 activates its own promoter in an autoregulatory loop.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Chen") (:form . "Chen") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "H.M.") (:form . "H.M.") 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5008722@unknown@formal@none@1@S@Here we show that the murine PU.1 promoter is also specifically and highly functional in B cell lines as well.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 63)\n  (:start . 51) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s931.4) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008723@unknown@formal@none@1@S@Oct-1 and Oct-2 can bind specifically to a site at base pair -55 in vitro, and this site is specifically protected in B cells in vivo.@(((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "CD") (:stem . "-55") (:form . "-55") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 88) (:start . 84)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 61))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 104)\n  (:start . 92) (:id . 62))\n ((:tag . "VBN") (:stem . "protect") (:form . "protected") (:end . 114)\n  (:start . 105) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 133) (:start . 129)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s931.5) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008724@unknown@formal@none@1@S@We also demonstrate that two other sites contribute to promoter activity in B cells; an Sp1 binding site adjacent to the octamer site, and the PU.1 autoregulatory site.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 162) (:start . 148) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s931.6) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008725@unknown@formal@none@1@S@Finally, we show that the B cell coactivator OBF-1/Bob1/OCA-B is only expressed in B cells and not in myeloid cells, and that OBF-1/Bob1/OCA-B can transactivate the PU.1 promoter in HeLa and myeloid cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 44)\n  (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "obf-1/bob1/oca-b") (:form . "OBF-1/Bob1/OCA-B")\n  (:end . 61) (:start . 45) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "OBF-1/Bob1/OCA-B") (:form . "OBF-1/Bob1/OCA-B")\n  (:end . 142) (:start . 126) (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 160) (:start . 147) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 178)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 186) (:start . 182)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 198)\n  (:start . 191) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x931.7.1) (:span 95 98)))\n (:nscopes ((:id . :x931.7.1) (:span 95 115)))\n (:identifiers (:sid . :s931.7) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008726@unknown@formal@none@1@S@This B cell restricted coactivator may be responsible for the B cell specific expression of PU.1 mediated by the octamer site.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 120)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x931.8.1) (:span 35 38)))\n (:hscopes ((:id . :x931.8.1) (:span 35 125)))\n (:identifiers (:sid . :s931.8) (:did . :|8663022|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008727@unknown@formal@none@1@S@Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.@(((:tag . "JJ") (:stem . "tissue-specific") (:form . "Tissue-specific")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ga-binding") (:form . "GA-binding") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s932.1) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008728@unknown@formal@none@1@S@The gammac chain is a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15), the expression of which is restricted to hematopoietic lineages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL)-2") (:form . "IL)-2") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-15") (:form . "IL-15") (:end . 109)\n  (:start . 104) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 126)\n  (:start . 116) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 135)\n  (:start . 130) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 149)\n  (:start . 139) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 166) (:start . 153) (:id . 74))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 175)\n  (:start . 167) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s932.2) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008730@unknown@formal@none@1@S@In order to better characterize the human gammac promoter and define the minimal tissue-specific promoter region, progressive 5'-deletion constructs of a segment extending 1053 base pairs upstream of the major transcription start site were generated and tested for promoter activity in various hematopoietic and nonhematopoietic cell types.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 18) (:start . 12)\n  (:id . 45))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 96) (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "progressive") (:form . "progressive") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "5'-deletion") (:form . "5'-deletion") (:end . 137)\n  (:start . 126) (:id . 60))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 148)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 161)\n  (:start . 154) (:id . 64))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . "CD") (:stem . "1053") (:form . "1053") (:end . 176) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 181) (:start . 177)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 187)\n  (:start . 182) (:id . 68))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 196)\n  (:start . 188) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 209)\n  (:start . 204) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 223) (:start . 210) (:id . 73))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 229)\n  (:start . 224) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 234) (:start . 230)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 239) (:start . 235)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 249)\n  (:start . 240) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 253) (:start . 250)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 260)\n  (:start . 254) (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 264) (:start . 261)\n  (:id . 80))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 273)\n  (:start . 265) (:id . 81))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 282)\n  (:start . 274) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 285) (:start . 283)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 293)\n  (:start . 286) (:id . 84))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 307) (:start . 294) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 311) (:start . 308)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "nonhematopoietic") (:form . "nonhematopoietic")\n  (:end . 328) (:start . 312) (:id . 87))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 333) (:start . 329)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 339)\n  (:start . 334) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 340) (:start . 339)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s932.4) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008731@unknown@formal@none@1@S@The -1053/+34 construct allowed promoter activity only in cells of hematopoietic origin, and tissue specificity was conserved in all other constructs tested.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "-1053/+34") (:form . "-1053/+34") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 149)\n  (:start . 139) (:id . 63))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 156)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s932.5) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008732@unknown@formal@none@1@S@The region downstream of -90 appeared critical for basal promoter activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-90") (:form . "-90") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s932.6) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008733@unknown@formal@none@1@S@It contains two potential Ets binding sites conserved in the murine gammac promoter gene, one of which was found essential for functional promoter activity as determined by mutational analysis.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mutational") (:form . "mutational") (:end . 183)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 192)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x932.7.1) (:span 16 25)))\n (:hscopes ((:id . :x932.7.1) (:span 16 88)))\n (:identifiers (:sid . :s932.7) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008734@unknown@formal@none@1@S@The functional Ets binding site was found to bind Ets family proteins, principally GA-binding protein and Elf-1 and could be transactivated by GABPalpha and -beta synergistically.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "RB") (:stem . "principally") (:form . "principally") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "JJ") (:stem . "ga-binding") (:form . "GA-binding") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "transactivate") (:form . "transactivated")\n  (:end . 139) (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GABPalpha") (:form . "GABPalpha") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 178) (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s932.8) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008735@unknown@formal@none@1@S@These results indicate that, as already reported for the IL2Rbeta promoter, GA-binding protein is an essential component of gammac basal promoter activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL2Rbeta") (:form . "IL2Rbeta") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ga-binding") (:form . "GA-binding") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x932.9.1) (:span 14 27)))\n (:hscopes ((:id . :x932.9.1) (:span 14 154)))\n (:identifiers (:sid . :s932.9) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008736@unknown@formal@none@1@S@Although GABP expression is not restricted to the hematopoietic lineage, its interaction with other specific factors may contribute to the tissue-specific expression of the gammac gene.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 154) (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x932.10.1) (:span 117 120)))\n (:ncues ((:id . :x932.10.2) (:span 28 31)))\n (:hscopes ((:id . :x932.10.1) (:span 117 184)))\n (:nscopes ((:id . :x932.10.2) (:span 28 71)))\n (:identifiers (:sid . :s932.10) (:did . :|8663060|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008737@unknown@formal@none@1@S@Multiple transcription factors are required for activation of human interleukin 9 gene in T cells.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 79)\n  (:start . 68) (:id . 51))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s933.1) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008738@unknown@formal@none@1@S@The genetic elements and regulatory mechanisms responsible for human interleukin 9 (IL-9) gene expression in a human T cell leukemia virus type I-transformed human T cell line, C5MJ2, were investigated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 58)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "i-transformed") (:form . "I-transformed")\n  (:end . 157) (:start . 144) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 175) (:start . 171)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "C5MJ2") (:form . "C5MJ2") (:end . 182)\n  (:start . 177) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 201)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s933.2) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008740@unknown@formal@none@1@S@Transient expression of the luciferase reporter gene linked to serially deleted sequences of the 5'-flanking region of the IL-9 gene has revealed several positive and negative regulatory elements involved in the basal and inducible expression of the IL-9 gene in C5MJ2 cells.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 59) (:start . 53)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "RB") (:stem . "serially") (:form . "serially") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 153)\n  (:start . 146) (:id . 64))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 186)\n  (:start . 176) (:id . 68))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 195)\n  (:start . 187) (:id . 69))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 204)\n  (:start . 196) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 217)\n  (:start . 212) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 231)\n  (:start . 222) (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 242)\n  (:start . 232) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 254) (:start . 250)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 259) (:start . 255)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 262) (:start . 260)\n  (:id . 81))\n ((:tag . "NN") (:stem . "c5mj2") (:form . "C5MJ2") (:end . 268)\n  (:start . 263) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 274)\n  (:start . 269) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s933.4) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008741@unknown@formal@none@1@S@An AP-1 site at -146 to -140 was shown to be involved in the expression of the IL-9 gene.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-146") (:form . "-146") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-140") (:form . "-140") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 38) (:start . 33)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 53)\n  (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s933.5) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008742@unknown@formal@none@1@S@A proximal region between -46 and -80 was identified as the minimum sequence for the basal and inducible expression of the IL-9 gene in C5MJ2 cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "-46") (:form . "-46") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-80") (:form . "-80") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "c5mj2") (:form . "C5MJ2") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s933.6) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008743@unknown@formal@none@1@S@Within this region, an NF-kappaB site at -59 to -50 and its adjacent 20-base pair upstream sequence were demonstrated to play a critical role for the IL-9 promoter activity.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-59") (:form . "-59") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-50") (:form . "-50") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . "JJ") (:stem . "20-base") (:form . "20-base") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 90)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 117)\n  (:start . 105) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 163)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 172)\n  (:start . 164) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s933.7) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008744@unknown@formal@none@1@S@DNA-protein binding studies indicated that NF-kappaB, c-Jun, and potentially novel proteins (around 35 kDa) can bind to this important sequence.@(((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x933.8.1) (:span 65 76)) ((:id . :x933.8.2) (:span 28 42)))\n (:hscopes ((:id . :x933.8.1) (:span 65 107))\n  ((:id . :x933.8.2) (:span 28 143)))\n (:identifiers (:sid . :s933.8) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008745@unknown@formal@none@1@S@Mutations at different sites within this proximal promoter region abolished the promoter activity as well as the DNA binding.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s933.9) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008746@unknown@formal@none@1@S@Taken together, these results suggest that the cooperation of different transcription factors is essential for IL-9 gene expression in T cells.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-9") (:form . "IL-9") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x933.10.1) (:span 30 37)))\n (:hscopes ((:id . :x933.10.1) (:span 30 142)))\n (:identifiers (:sid . :s933.10) (:did . :|8663174|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008747@unknown@formal@none@1@S@Mapping of the transcriptional repression domain of the lymphoid-specific transcription factor oct-2A.@(((:tag . "NN") (:stem . "mapping") (:form . "Mapping") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 30) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 73) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 52))\n ((:tag . "NNP") (:stem . "oct-2A") (:form . "oct-2A") (:end . 101)\n  (:start . 95) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s934.1) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008748@unknown@formal@none@1@S@The lymphoid-specific transcription factor Oct-2a is implicated in B cell-specific transcriptional activity via the octamer motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 42)\n  (:start . 36) (:id . 45))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 49)\n  (:start . 43) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 82) (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 98) (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 111) (:start . 108)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 55))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 123)\n  (:start . 116) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 129)\n  (:start . 124) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s934.2) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008750@unknown@formal@none@1@S@The transcriptional activity of both domains is strongly potentiated by interactions with distinct B cell-specific coactivators.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "VBN") (:stem . "potentiate") (:form . "potentiated") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 84)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "coactivator") (:form . "coactivators") (:end . 127)\n  (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s934.4) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008751@unknown@formal@none@1@S@Recently, we have identified a repression domain located within the N terminus of Oct-2a (amino acids 2-99).@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "2-99") (:form . "2-99") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s934.5) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008752@unknown@formal@none@1@S@When this domain was transferred to a potent activator, transcription was strongly inhibited.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "transfer") (:form . "transferred") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s934.6) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008753@unknown@formal@none@1@S@In this study we present a deletion analysis of the N-terminal region of Oct-2a to determine the minimal repression domain.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s934.7) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008754@unknown@formal@none@1@S@We identified a stretch of 23 amino acids, rich in serine and threonine residues, which was responsible for most of the repression activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stretch") (:form . "stretch") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rich") (:form . "rich") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "threonine") (:form . "threonine") (:end . 71)\n  (:start . 62) (:id . 55))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 103)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 130)\n  (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s934.8) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008755@unknown@formal@none@1@S@We show that repression is strongly dependent on the type of enhancer present in the reporter plasmid as well as on the cell line tested.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 136)\n  (:start . 130) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s934.9) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008756@unknown@formal@none@1@S@The possibility that Oct-2a can act as an activator and/or a repressor may have important consequences for the function of Oct-2a in B cell differentiation and other developmental processes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 102)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Oct-2a") (:form . "Oct-2a") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 155) (:start . 140) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 179) (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 189)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x934.10.1) (:span 71 74)) ((:id . :x934.10.2) (:span 4 15)))\n (:hscopes ((:id . :x934.10.1) (:span 71 189))\n  ((:id . :x934.10.2) (:span 4 70)))\n (:identifiers (:sid . :s934.10) (:did . :|8663230|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008757@unknown@formal@none@1@S@The role of BSAP (Pax-5) in B-cell development.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Pax-5") (:form . "Pax-5") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 34)\n  (:start . 28) (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 46)\n  (:start . 35) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s935.1) (:did . :|8664547|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008758@unknown@formal@none@1@S@The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hierarchy") (:form . "hierarchy") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 119)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 132)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s935.2) (:did . :|8664547|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008760@unknown@formal@none@1@S@Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "bsap") (:form . "BSAP") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 87) (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 106)\n  (:start . 97) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 146) (:start . 132) (:id . 61))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 158)\n  (:start . 147) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 67))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 188)\n  (:start . 182) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 204) (:start . 189) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s935.4) (:did . :|8664547|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008761@unknown@formal@none@1@S@Induction of CIITA and modification of in vivo HLA-DR promoter occupancy in normal thymic epithelial cells treated with IFN-gamma: similarities and distinctions with respect to HLA-DR-constitutive B cells.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 143)\n  (:start . 131) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "distinction") (:form . "distinctions") (:end . 160)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "hla-dr-constitutive")\n  (:form . "HLA-DR-constitutive") (:end . 196) (:start . 177) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 198) (:start . 197)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 204)\n  (:start . 199) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s936.1) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008762@unknown@formal@none@1@S@In this study, the IFN-gamma induction of MHC class II gene expression in primary cultures of thymic epithelial cells (TEC) was analyzed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s936.2) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008763@unknown@formal@none@1@S@This cellular system offers the advantage that MHC class II induction is studied in a "physiologic" cell lineage that, as a result of this expression within the thymus, is thought to participate to the selection and maturation of the T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "offer") (:form . "offers") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "\\"physiologic") (:form . "\\"physiologic")\n  (:end . 98) (:start . 86) (:id . 57))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 130)\n  (:start . 124) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 138) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 68))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 167)\n  (:start . 161) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 179)\n  (:start . 172) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 194)\n  (:start . 183) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 211)\n  (:start . 202) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 80))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 226)\n  (:start . 216) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 233) (:start . 230)\n  (:id . 83))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 235) (:start . 234)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 241)\n  (:start . 236) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x936.3.1) (:span 172 179)))\n (:hscopes ((:id . :x936.3.1) (:span 169 241)))\n (:identifiers (:sid . :s936.3) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008764@unknown@formal@none@1@S@It was found that the MHC class II gene expression was associated with the de novo transcription of the gene encoding the CIITA trans-activator, a crucial MHC class II gene regulatory factor.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 143) (:start . 128) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 183)\n  (:start . 173) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 190)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s936.4) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008765@unknown@formal@none@1@S@Furthermore, the anatomy of interaction between the MHC class II DRA promoter and corresponding binding factors was analyzed by in vivo DNAse I footprint.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "anatomy") (:form . "anatomy") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNAse") (:form . "DNAse") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s936.5) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008766@unknown@formal@none@1@S@It was found that treatment with IFN-gamma induces changes in the occupancy of the DRA gene regulatory sequences by nuclear factors.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s936.6) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008767@unknown@formal@none@1@S@The resulting occupancy displays strong similarities with the one observed in the MHC class II-constitutive B cells, represented by both the Burkitt lymphoma line Raji and normal tonsil- derived B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ii-constitutive") (:form . "II-constitutive")\n  (:end . 107) (:start . 92) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 128)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 162) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 178)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "tonsil-") (:form . "tonsil-") (:end . 186)\n  (:start . 179) (:id . 70))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 196) (:start . 195)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s936.7) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008768@unknown@formal@none@1@S@However, some peculiar differences were observed between the TEC, either IFN-gamma-induced or not, and the constitutive B cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peculiar") (:form . "peculiar") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 90) (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x936.8.1) (:span 94 97)))\n (:nscopes ((:id . :x936.8.1) (:span 94 97)))\n (:identifiers (:sid . :s936.8) (:did . :|8666795|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008770@unknown@formal@none@1@S@An alternatively spliced isoform of the Spi-B transcription factor.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "alternatively") (:form . "alternatively")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "VBN") (:stem . "splice") (:form . "spliced") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s937.1) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008771@unknown@formal@none@1@S@Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells.@(((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "spi-1/pu.1") (:form . "Spi-1/PU.1") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s937.2) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008772@unknown@formal@none@1@S@The Ets proteins share a conserved Ets domain that mediates specific DNA binding.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s937.3) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008773@unknown@formal@none@1@S@Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif.@(((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "5'-ggaa-3") (:form . "5'-GGAA-3") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s937.4) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008774@unknown@formal@none@1@S@Up to date, the biological function of Spi-B remains unknown.@(((:tag . "IN") (:stem . "up") (:form . "Up") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 26)\n  (:start . 16) (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x937.5.1) (:span 53 60)))\n (:hscopes ((:id . :x937.5.1) (:span 12 60)))\n (:identifiers (:sid . :s937.5) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008775@unknown@formal@none@1@S@Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 17)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 38) (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "alternatively") (:form . "alternatively")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "splice") (:form . "spliced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "deltaspi-b") (:form . "deltaSpi-B") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s937.6) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008776@unknown@formal@none@1@S@In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 13)\n  (:start . 5) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deltaspi-b") (:form . "deltaspi-B") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "spi-b") (:form . "spi-B") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 75) (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s937.7) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008777@unknown@formal@none@1@S@DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts.@(((:tag . "NNP") (:stem . "DeltaSpi-B") (:form . "DeltaSpi-B") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x937.8.1) (:span 23 26)))\n (:nscopes ((:id . :x937.8.1) (:span 23 43)))\n (:identifiers (:sid . :s937.8) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008778@unknown@formal@none@1@S@We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "raise") (:form . "raise") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "delta") (:form . "delta") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "spi-b") (:form . "Spi-B") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "recruit") (:form . "recruiting") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Spi-B") (:form . "Spi-B") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x937.9.1) (:span 41 46)) ((:id . :x937.9.2) (:span 3 23)))\n (:hscopes ((:id . :x937.9.1) (:span 41 117))\n  ((:id . :x937.9.2) (:span 3 117)))\n (:identifiers (:sid . :s937.9) (:did . :|8670269|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008780@unknown@formal@none@1@S@IL-10 is a potent mediator of human B cell growth and plasma cell formation.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s938.2) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008781@unknown@formal@none@1@S@However, signal transduction of IL-10 in B cells is poorly understood.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s938.3) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008782@unknown@formal@none@1@S@In this study the effect of IL-10 on the expression of the protooncogene c-fos was investigated, because Fos plays a potential role in the regulation of B cell proliferation and differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protooncogene") (:form . "protooncogene")\n  (:end . 72) (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 95)\n  (:start . 83) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 126)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 159) (:start . 155)\n  (:id . 70))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 173) (:start . 160) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 193) (:start . 178) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x938.4.1) (:span 117 126)))\n (:hscopes ((:id . :x938.4.1) (:span 117 193)))\n (:identifiers (:sid . :s938.4) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008783@unknown@formal@none@1@S@B cells were purified from buffy coat preparations of healthy blood donors by positive selection using an anti CD20 monoclonal antibody and a MiniMACS separation unit.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "buffy") (:form . "buffy") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "coat") (:form . "coat") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "preparation") (:form . "preparations") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD20") (:form . "CD20") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "MiniMACS") (:form . "MiniMACS") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 161)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s938.5) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008784@unknown@formal@none@1@S@B cells were prestimulated with SAC for 48 hrs.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "prestimulate") (:form . "prestimulated")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SAC") (:form . "SAC") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hr") (:form . "hrs") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s938.6) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008785@unknown@formal@none@1@S@Then, cells were incubated with medium or IL-10 (100 ng/ml) for 10 to 120 min.@(((:tag . "RB") (:stem . "then") (:form . "Then") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/ml") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 66) (:start . 64)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 57))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 73) (:start . 70)\n  (:id . 58))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 77) (:start . 74)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s938.7) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008786@unknown@formal@none@1@S@RNA was extracted by phenol/chloroform and c-fos expression was analyzed by PCR assisted mRNA assay.@(((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phenol/chloroform") (:form . "phenol/chloroform")\n  (:end . 38) (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "assist") (:form . "assisted") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s938.8) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008787@unknown@formal@none@1@S@A significant 2-4 fold increase of c-fos expression was observed within 30 min of stimulation with IL-10 (p < 0.01).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "CD") (:stem . "2-4") (:form . "2-4") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fold") (:form . "fold") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 104)\n  (:start . 99) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s938.9) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008788@unknown@formal@none@1@S@After 2 hrs c-fos expression declined to basal levels.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "hr") (:form . "hrs") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "VBD") (:stem . "decline") (:form . "declined") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s938.10) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008790@unknown@formal@none@1@S@The IL-10 effect on c-fos expression was not blocked by polymyxin B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "polymyxin") (:form . "polymyxin") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x938.12.1) (:span 41 44)))\n (:nscopes ((:id . :x938.12.1) (:span 0 67)))\n (:identifiers (:sid . :s938.12) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008791@unknown@formal@none@1@S@Using the tyrosine kinase inhibitor genistein (10 microM) a complete inhibition of IL-10 induced c-fos expression was observed.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "genistein") (:form . "genistein") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s938.13) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008792@unknown@formal@none@1@S@In addition, H-7 (10 microM), a specific inhibitor of serine/threonine kinases, significantly blocked IL-10 mediated c-fos expression (p < 0.05).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "H-7") (:form . "H-7") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 27)\n  (:start . 21) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 40)\n  (:start . 32) (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 50)\n  (:start . 41) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 54))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 70) (:start . 54) (:id . 55))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 93) (:start . 80) (:id . 58))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "mediated") (:form . "mediated") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s938.14) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008793@unknown@formal@none@1@S@In conclusion, these data show that IL-10 induces c-fos expression in human B-cells by activation of tyrosine and serine/threonine kinases.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "b-cell") (:form . "B-cells") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 130) (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s938.15) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008794@unknown@formal@none@1@S@Since this is the first report on IL-10 induced signal transduction, these data may help to identify the intracellular mechanisms by which IL-10 stimulates human B-cells.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 118) (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 155)\n  (:start . 145) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 161)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "b-cell") (:form . "B-cells") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x938.16.1) (:span 80 83)))\n (:hscopes ((:id . :x938.16.1) (:span 80 169)))\n (:identifiers (:sid . :s938.16) (:did . :|8675228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008795@unknown@formal@none@1@S@IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 35)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd3-stimulated") (:form . "CD3-stimulated")\n  (:end . 76) (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 93)\n  (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 107)\n  (:start . 96) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s939.1) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008796@unknown@formal@none@1@S@IL-10 markedly reduces nuclear factor (NF)-kappa B/Rel nuclear activity induced in PBMC by stimulation with the anti-CD3 mAb OKT3.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "okt3") (:form . "OKT3") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s939.2) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008797@unknown@formal@none@1@S@The inhibition is exerted specifically on the NF-kappa B/Rel activation induced by mAb OKT3, and not that produced by PMA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "okt3") (:form . "OKT3") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x939.3.1) (:span 97 100)))\n (:nscopes ((:id . :x939.3.1) (:span 97 121)))\n (:identifiers (:sid . :s939.3) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008798@unknown@formal@none@1@S@As judged by supershifting the DNA-protein complexes with Abs recognizing specific components of the NF-kappa B/Rel protein family, the p50/p65 (Rel A) heterodimeric form of NF-kappa B is primarily affected.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "judge") (:form . "judged") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "supershifte") (:form . "supershifting") (:end . 26)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "recognize") (:form . "recognizing") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 165) (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 182)\n  (:start . 174) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 206)\n  (:start . 198) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s939.4) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008800@unknown@formal@none@1@S@IL-10 inhibitory activity is exerted on T lymphocytes and is mediated by monocytes.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s939.6) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008801@unknown@formal@none@1@S@Indeed, monocytes pretreated with IL-10 are able so inhibit NF-kappa B nuclear activity in purified T lymphocytes stimulated with OKT3.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s939.7) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008802@unknown@formal@none@1@S@Soluble factors do not appear to be involved in the mechanism of inhibition.@(((:tag . "JJ") (:stem . "soluble") (:form . "Soluble") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x939.8.2) (:span 23 29)))\n (:ncues ((:id . :x939.8.1) (:span 19 22)))\n (:hscopes ((:id . :x939.8.2) (:span 0 75)))\n (:nscopes ((:id . :x939.8.1) (:span 0 75)))\n (:identifiers (:sid . :s939.8) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008803@unknown@formal@none@1@S@On the other hand, the up-regulation of CD80 Ag, found on monocytes obtained from PBMC incubated with OKT3, is not detected after addition of IL-10, and the anti-CD28 mAb CLB-CD28/1 restores the NF-kappa B/Rel nuclear activity in IL-10-inhibited lymphocytes.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 36) (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD80") (:form . "CD80") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ag") (:form . "Ag") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 54) (:start . 49)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 67)\n  (:start . 58) (:id . 55))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 76)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 96)\n  (:start . 87) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 123)\n  (:start . 115) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 129)\n  (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 138)\n  (:start . 130) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 166)\n  (:start . 157) (:id . 73))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 170) (:start . 167)\n  (:id . 74))\n ((:tag . "NN") (:stem . "clb-cd28/1") (:form . "CLB-CD28/1") (:end . 181)\n  (:start . 171) (:id . 75))\n ((:tag . "VBZ") (:stem . "restore") (:form . "restores") (:end . 190)\n  (:start . 182) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 203)\n  (:start . 195) (:id . 78))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 209)\n  (:start . 204) (:id . 79))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 217)\n  (:start . 210) (:id . 80))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 226)\n  (:start . 218) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "il-10-inhibited") (:form . "IL-10-inhibited")\n  (:end . 245) (:start . 230) (:id . 83))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 257)\n  (:start . 246) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x939.9.1) (:span 111 114)))\n (:nscopes ((:id . :x939.9.1) (:span 19 147)))\n (:identifiers (:sid . :s939.9) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008804@unknown@formal@none@1@S@Therefore, the NF-kappa B/Rel inhibition might be ascribed to a lack of cooperation between accessory cells and T lymphocytes, resulting from down-regulation of a costimulatory molecule, such as CD80, produced by IL-10 on activated monocytes.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "ascribe") (:form . "ascribed") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 157) (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 176) (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 185)\n  (:start . 177) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 191) (:start . 187)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CD80") (:form . "CD80") (:end . 199) (:start . 195)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 212) (:start . 210)\n  (:id . 76))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 218)\n  (:start . 213) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 221) (:start . 219)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 231)\n  (:start . 222) (:id . 79))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 241)\n  (:start . 232) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x939.10.2) (:span 41 46)))\n (:ncues ((:id . :x939.10.1) (:span 64 68)))\n (:hscopes ((:id . :x939.10.2) (:span 11 241)))\n (:nscopes ((:id . :x939.10.1) (:span 64 125)))\n (:identifiers (:sid . :s939.10) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008805@unknown@formal@none@1@S@Our results demonstrate that IL-10 can inhibit the induction of NF-kappa B/Rel nuclear activity in CD3-stimulated T lymphocytes.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cd3-stimulated") (:form . "CD3-stimulated")\n  (:end . 113) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s939.11) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008806@unknown@formal@none@1@S@Since inappropriate activation of kappa B-driven genes has a physiopathologic role in a number of diseases, such as HIV infection, our findings support the possibility of using this cytokine to suppress an undesirable activation of these transcription factors.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inappropriate") (:form . "inappropriate")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "b-driven") (:form . "B-driven") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "physiopathologic") (:form . "physiopathologic")\n  (:end . 77) (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 167)\n  (:start . 156) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 176) (:start . 171)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 202)\n  (:start . 194) (:id . 74))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "undesirable") (:form . "undesirable") (:end . 217)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 228)\n  (:start . 218) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 78))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 237)\n  (:start . 232) (:id . 79))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 251) (:start . 238) (:id . 80))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 259)\n  (:start . 252) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x939.12.1) (:span 156 167)))\n (:hscopes ((:id . :x939.12.1) (:span 156 259)))\n (:identifiers (:sid . :s939.12) (:did . :|8690900|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008807@unknown@formal@none@1@S@Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "JJ") (:stem . "1-dependent") (:form . "1-dependent") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 46) (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 72)\n  (:start . 61) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 74) (:start . 73)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ca2+/calmodulin") (:form . "Ca2+/calmodulin")\n  (:end . 98) (:start . 83) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 105)\n  (:start . 99) (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 110) (:start . 106)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IV/Gr") (:form . "IV/Gr") (:end . 116)\n  (:start . 111) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s940.1) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008808@unknown@formal@none@1@S@The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ca2+/calmodulin-dependent")\n  (:form . "Ca2+/calmodulin-dependent") (:end . 29) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 44)\n  (:start . 38) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CaMK") (:form . "CaMK") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IV/Gr") (:form . "IV/Gr") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 169)\n  (:start . 161) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 187)\n  (:start . 177) (:id . 72))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 73))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 195) (:start . 193)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 204)\n  (:start . 196) (:id . 75))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "Ca(2+)-dependent") (:form . "Ca(2+)-dependent")\n  (:end . 233) (:start . 217) (:id . 79))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 249) (:start . 234) (:id . 80))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 256)\n  (:start . 250) (:id . 81))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 261) (:start . 257)\n  (:id . 82))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 268)\n  (:start . 262) (:id . 83))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 272) (:start . 269)\n  (:id . 84))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 283)\n  (:start . 273) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 284) (:start . 283)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x940.2.1) (:span 177 192)))\n (:hscopes ((:id . :x940.2.1) (:span 177 283)))\n (:identifiers (:sid . :s940.2) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008810@unknown@formal@none@1@S@CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin.@(((:tag . "NNP") (:stem . "CaMKIV/") (:form . "CaMKIV/") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Gr") (:form . "Gr") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 55) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s940.4) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008811@unknown@formal@none@1@S@AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells.@(((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "integral") (:form . "integral") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 95) (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 138)\n  (:start . 127) (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 167)\n  (:start . 162) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s940.5) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008812@unknown@formal@none@1@S@We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CaMKIV/Gr") (:form . "CaMKIV/Gr") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "reconstitute") (:form . "reconstitutes")\n  (:end . 43) (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "non-t") (:form . "non-T") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s940.6) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008813@unknown@formal@none@1@S@These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CaMKIV/Gr") (:form . "CaMKIV/Gr") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "Ca(2+)-regulated") (:form . "Ca(2+)-regulated")\n  (:end . 71) (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s940.7) (:did . :|8691123|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008814@unknown@formal@none@1@S@Cytokine-modulating activity of tepoxalin, a new potential antirheumatic.@(((:tag . "JJ") (:stem . "cytokine-modulating")\n  (:form . "Cytokine-modulating") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "antirheumatic") (:form . "antirheumatic")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s941.1) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008815@unknown@formal@none@1@S@Tepoxalin is a new dual cyclooxygenase/5-lipoxygenase anti-inflammatory compound currently under clinical investigation.@(((:tag . "NNP") (:stem . "Tepoxalin") (:form . "Tepoxalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cyclooxygenase/5-lipoxygenase")\n  (:form . "cyclooxygenase/5-lipoxygenase") (:end . 53) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 71) (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 80)\n  (:start . 72) (:id . 49))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 90)\n  (:start . 81) (:id . 50))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 96) (:start . 91)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 105)\n  (:start . 97) (:id . 52))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 119) (:start . 106) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s941.2) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008816@unknown@formal@none@1@S@It has been shown to possess anti-inflammatory activity in a variety of animal models and more recently to inhibit IL-2 induced signal transduction.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "possess") (:form . "possess") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 46) (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 147)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s941.3) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008817@unknown@formal@none@1@S@The current study was conducted to evaluate the cytokine modulating activity of tepoxalin and the role of iron in these effects.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "modulating") (:form . "modulating") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s941.4) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008818@unknown@formal@none@1@S@In human peripheral blood mononuclear cells (PBMC) stimulated with OKT3/PMA, tepoxalin inhibited lymphocyte proliferation with an IC50 of 6 microM.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "OKT3/PMA") (:form . "OKT3/PMA") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 121) (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ic50") (:form . "IC50") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s941.5) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008820@unknown@formal@none@1@S@Cytotoxicity was not demonstrated at these concentrations.@(((:tag . "NNP") (:stem . "Cytotoxicity") (:form . "Cytotoxicity") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 57) (:start . 43) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x941.7.1) (:span 17 20)))\n (:nscopes ((:id . :x941.7.1) (:span 0 57)))\n (:identifiers (:sid . :s941.7) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008821@unknown@formal@none@1@S@Add-back experiments with either cytokines (IL-2 or IL-6), LTB4 or conditioned media failed to restore the proliferative response in the presence of tepoxalin.@(((:tag . "JJ") (:stem . "add-back") (:form . "Add-back") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ltb4") (:form . "LTB4") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "condition") (:form . "conditioned") (:end . 78)\n  (:start . 67) (:id . 55))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 84)\n  (:start . 79) (:id . 56))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 91) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 120) (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x941.8.1) (:span 85 91)))\n (:nscopes ((:id . :x941.8.1) (:span 85 158)))\n (:identifiers (:sid . :s941.8) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008822@unknown@formal@none@1@S@However, the concurrent addition of iron (in the form of ferrous or ferric chloride and other iron salts) reversed the inhibition of proliferation caused by tepoxalin.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "concurrent") (:form . "concurrent") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ferrous") (:form . "ferrous") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ferric") (:form . "ferric") (:end . 74)\n  (:start . 68) (:id . 56))\n ((:tag . "NN") (:stem . "chloride") (:form . "chloride") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 98) (:start . 94)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "salt") (:form . "salts") (:end . 104) (:start . 99)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "reverse") (:form . "reversed") (:end . 114)\n  (:start . 106) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 129)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 146) (:start . 133) (:id . 67))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 166)\n  (:start . 157) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s941.9) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008823@unknown@formal@none@1@S@Tepoxalin also inhibits the activation of NF kappa B, a transcription factor which acts on several cytokine genes.@(((:tag . "NNP") (:stem . "Tepoxalin") (:form . "Tepoxalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s941.10) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008824@unknown@formal@none@1@S@Tepoxalin's effect on NF kappa B is also reversed by the addition of iron salts.@(((:tag . "NNP") (:stem . "Tepoxalin") (:form . "Tepoxalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "salt") (:form . "salts") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s941.11) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008825@unknown@formal@none@1@S@These data suggest that the action of tepoxalin to inhibit proliferation in PBMC may be at least in part due to its ability to reduce the amount of available iron resulting in decreased activation of NF kappa B and subsequent inhibition of cytokine production.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tepoxalin") (:form . "tepoxalin") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "VB") (:stem . "reduce") (:form . "reduce") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 144)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 157)\n  (:start . 148) (:id . 70))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 172)\n  (:start . 163) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 185)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 196)\n  (:start . 186) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 202) (:start . 200)\n  (:id . 77))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 225)\n  (:start . 215) (:id . 81))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 236)\n  (:start . 226) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 83))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 248)\n  (:start . 240) (:id . 84))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 259)\n  (:start . 249) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x941.12.1) (:span 81 84))\n  ((:id . :x941.12.2) (:span 11 18)))\n (:hscopes ((:id . :x941.12.1) (:span 81 259))\n  ((:id . :x941.12.2) (:span 11 259)))\n (:identifiers (:sid . :s941.12) (:did . :|8707445|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008826@unknown@formal@none@1@S@Gene transcription through activation of G-protein-coupled chemoattractant receptors.@(((:tag . "NNP") (:stem . "Gene") (:form . "Gene") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "g-protein-coupled") (:form . "G-protein-coupled")\n  (:end . 58) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 74) (:start . 59) (:id . 48))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 84)\n  (:start . 75) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s942.1) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008827@unknown@formal@none@1@S@Receptors for leukocyte chemoattractants, including chemokines, are traditionally considered to be responsible for the activation of special leukocyte functions such as chemotaxis, degranulation, and the release of superoxide anions.@(((:tag . "NNS") (:stem . "receptor") (:form . "Receptors") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "chemoattractant") (:form . "chemoattractants")\n  (:end . 40) (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "traditionally") (:form . "traditionally")\n  (:end . 81) (:start . 68) (:id . 51))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 110)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 129)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "special") (:form . "special") (:end . 140)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 150)\n  (:start . 141) (:id . 61))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 160)\n  (:start . 151) (:id . 62))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 165) (:start . 161)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chemotaxis") (:form . "chemotaxis") (:end . 179)\n  (:start . 169) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 66))\n ((:tag . "NN") (:stem . "degranulation") (:form . "degranulation")\n  (:end . 194) (:start . 181) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 211)\n  (:start . 204) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 72))\n ((:tag . "NN") (:stem . "superoxide") (:form . "superoxide") (:end . 225)\n  (:start . 215) (:id . 73))\n ((:tag . "NNS") (:stem . "anion") (:form . "anions") (:end . 232)\n  (:start . 226) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s942.2) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008828@unknown@formal@none@1@S@Recently, these G-protein-coupled serpentine receptors have been found to transduce signals leading to gene transcription and translation in leukocytes.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "g-protein-coupled") (:form . "G-protein-coupled")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "serpentine") (:form . "serpentine") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 121) (:start . 108) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 137)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 151)\n  (:start . 141) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s942.3) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008830@unknown@formal@none@1@S@Activation of transcription factors through these receptors involves G-protein coupling and the activation of protein kinases.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NNP") (:stem . "G-protein") (:form . "G-protein") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "coupling") (:form . "coupling") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 56))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s942.5) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008831@unknown@formal@none@1@S@The underlying signaling pathways appear to be different from those utilized by TNF-alpha, a better characterized cytokine that induces the transcription of immediate-early genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 99) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 113) (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 172) (:start . 157) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 178)\n  (:start . 173) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x942.6.1) (:span 34 40)))\n (:hscopes ((:id . :x942.6.1) (:span 0 178)))\n (:identifiers (:sid . :s942.6) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008832@unknown@formal@none@1@S@Chemoattractants stimulate the expression of several inflammatory cytokines and chemokines, which in turn may activate their respective receptors and initiate an autocrine regulatory mechanism for persistent cytokine and chemokine gene expression.@(((:tag . "NNP") (:stem . "Chemoattractant") (:form . "Chemoattractants")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 65)\n  (:start . 53) (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 75)\n  (:start . 66) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 90)\n  (:start . 80) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 124)\n  (:start . 119) (:id . 58))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 145)\n  (:start . 136) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 158)\n  (:start . 150) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 161) (:start . 159)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 171)\n  (:start . 162) (:id . 64))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 182)\n  (:start . 172) (:id . 65))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 192)\n  (:start . 183) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 196) (:start . 193)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 207)\n  (:start . 197) (:id . 68))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 216)\n  (:start . 208) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 70))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 230)\n  (:start . 221) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 235) (:start . 231)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 246)\n  (:start . 236) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x942.7.1) (:span 106 109)))\n (:hscopes ((:id . :x942.7.1) (:span 106 246)))\n (:identifiers (:sid . :s942.7) (:did . :|8723387|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008833@unknown@formal@none@1@S@Regulation of gene expression at early stages of B-cell and T-cell differentiation.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cell") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 82) (:start . 67) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s943.1) (:did . :|8725939|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008834@unknown@formal@none@1@S@The expression of distinct sets of genes at different stages of B-lymphocyte and T-lymphocyte differentiation is controlled at the level of transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B-lymphocyte") (:form . "B-lymphocyte") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte") (:end . 93)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 109) (:start . 94) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s943.2) (:did . :|8725939|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008835@unknown@formal@none@1@S@A number of recent studies have described interactions between transcription factors in lymphocytes that provide new insights into mechanisms regulating gene expression.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 99)\n  (:start . 88) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 152)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 168)\n  (:start . 158) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s943.3) (:did . :|8725939|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008836@unknown@formal@none@1@S@These mechanisms include the assembly of higher order nucleoprotein complexes and other protein-protein interactions that enhance the functional specificity of transcriptional regulators in lymphocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 47) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleoprotein") (:form . "nucleoprotein")\n  (:end . 67) (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 103) (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 116)\n  (:start . 104) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 129)\n  (:start . 122) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 144)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 156)\n  (:start . 145) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 175) (:start . 160) (:id . 62))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 186)\n  (:start . 176) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 201)\n  (:start . 190) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s943.4) (:did . :|8725939|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008837@unknown@formal@none@1@S@Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 63)\n  (:start . 55) (:id . 48))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 72)\n  (:start . 64) (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 82)\n  (:start . 73) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s944.1) (:did . :|8739563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008838@unknown@formal@none@1@S@Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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5008840@unknown@formal@none@1@S@Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 66) (:start . 51) (:id . 48))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 76)\n  (:start . 67) (:id . 49))\n ((:tag . "NNP") (:stem . "PTK") (:form . "PTK") (:end . 80) (:start . 77)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 91)\n  (:start . 81) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 103)\n  (:start . 95) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 123)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 151)\n  (:start . 145) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 160)\n  (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 173)\n  (:start . 168) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 175) (:start . 174)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 67))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 187)\n  (:start . 181) (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 192) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 203)\n  (:start . 193) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x944.4.1) (:span 19 32)))\n (:hscopes ((:id . :x944.4.1) (:span 19 203)))\n (:identifiers (:sid . :s944.4) (:did . :|8739563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008841@unknown@formal@none@1@S@This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g. inflammation and atherosclerosis).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pathophysiological") (:form . "pathophysiological")\n  (:end . 49) (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 90)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 56))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 128)\n  (:start . 116) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 148) (:start . 133) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x944.5.1) (:span 5 8)))\n (:hscopes ((:id . :x944.5.1) (:span 5 149)))\n (:identifiers (:sid . :s944.5) (:did . :|8739563|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008842@unknown@formal@none@1@S@Transcription specific differences visualized by fluorescence in situ hybridization pattern on interphase nuclei of different cell types.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 34)\n  (:start . 23) (:id . 44))\n ((:tag . "VBN") (:stem . "visualize") (:form . "visualized") (:end . 45)\n  (:start . 35) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 61)\n  (:start . 49) (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 69) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 83) (:start . 70) (:id . 50))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 91)\n  (:start . 84) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interphase") (:form . "interphase") (:end . 105)\n  (:start . 95) (:id . 53))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 112)\n  (:start . 106) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 125)\n  (:start . 116) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 136)\n  (:start . 131) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s945.1) (:did . :|8747083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008843@unknown@formal@none@1@S@Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the cDNA of the myf3 gene revealed the following results: Human rhabdomyosarcoma cells, characterized by a high expression of myf3 show intensive hybridization signals in their interphase.@(((:tag . "NN") (:stem . "application") (:form . "Application") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "\\"formamide") (:form . "\\"formamide") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "\\"material") (:form . "\\"material") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "VBG") (:stem . "preserve") (:form . "preserving") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 86) (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "myf3") (:form . "myf3") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "following") (:form . "following") (:end . 151)\n  (:start . 142) (:id . 66))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 160) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "rhabdomyosarcoma") (:form . "rhabdomyosarcoma")\n  (:end . 183) (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 204) (:start . 191) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 225)\n  (:start . 215) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "myf3") (:form . "myf3") (:end . 233) (:start . 229)\n  (:id . 79))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 238) (:start . 234)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "intensive") (:form . "intensive") (:end . 248)\n  (:start . 239) (:id . 81))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 262) (:start . 249) (:id . 82))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 270)\n  (:start . 263) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 273) (:start . 271)\n  (:id . 84))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 279)\n  (:start . 274) (:id . 85))\n ((:tag . "NN") (:stem . "interphase") (:form . "interphase") (:end . 290)\n  (:start . 280) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 291) (:start . 290)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s945.2) (:did . :|8747083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008844@unknown@formal@none@1@S@RNase treatment prior to hybridization considerably reduces the size of this signals.@(((:tag . "NNP") (:stem . "RNase") (:form . "RNase") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "RB") (:stem . "considerably") (:form . "considerably") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s945.3) (:did . :|8747083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008845@unknown@formal@none@1@S@In comparison, isolated nuclei of human lymphocytes in which no need for the expression of this gene exists, show barely hybridization signals.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "need") (:form . "need") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "RB") (:stem . "barely") (:form . "barely") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 134) (:start . 121) (:id . 64))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x945.4.1) (:span 61 63)))\n (:nscopes ((:id . :x945.4.1) (:span 61 107)))\n (:identifiers (:sid . :s945.4) (:did . :|8747083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008846@unknown@formal@none@1@S@Correspondingly, RNase treatment had no effect on hybridization pattern at all.@(((:tag . "RB") (:stem . "correspondingly") (:form . "Correspondingly")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RNase") (:form . "RNase") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x945.5.1) (:span 37 39)))\n (:nscopes ((:id . :x945.5.1) (:span 37 78)))\n (:identifiers (:sid . :s945.5) (:did . :|8747083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008847@unknown@formal@none@1@S@In conclusion an increased transcription efficiency of a cell type specific gene is accompanied by a higher hybridization accessibility in the corresponding cell nuclei.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "accessibility") (:form . "accessibility")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 156)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 161) (:start . 157)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 168)\n  (:start . 162) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s945.6) (:did . :|8747083|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008848@unknown@formal@none@1@S@Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation.@(((:tag . "NNP") (:stem . "Alpha") (:form . "Alpha") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd49d/cd29") (:form . "CD49d/CD29") (:end . 26)\n  (:start . 16) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 50) (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 182)\n  (:start . 171) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x946.1.1) (:span 128 135)))\n (:nscopes ((:id . :x946.1.1) (:span 128 182)))\n (:identifiers (:sid . :s946.1) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008850@unknown@formal@none@1@S@Similar to expression of IL-2, we demonstrated that recombinant vascular-cell adhesion molecule-1, when co-immobilized with anti-CD3 mAb, significantly enhanced the induction of transcription factors NF-AT, AP-1, and NF-kappa B as determined by electromobility shift assays.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 46)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "vascular-cell") (:form . "vascular-cell")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "co-immobilize") (:form . "co-immobilized")\n  (:end . 118) (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 151) (:start . 138) (:id . 62))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 160)\n  (:start . 152) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 174)\n  (:start . 165) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 199)\n  (:start . 192) (:id . 68))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 205)\n  (:start . 200) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 206) (:start . 205)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 211) (:start . 207)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 225)\n  (:start . 217) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 227) (:start . 226)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 230) (:start . 228)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 241)\n  (:start . 231) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 244) (:start . 242)\n  (:id . 78))\n ((:tag . "NN") (:stem . "electromobility") (:form . "electromobility")\n  (:end . 260) (:start . 245) (:id . 79))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 266)\n  (:start . 261) (:id . 80))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 273)\n  (:start . 267) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s946.3) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008851@unknown@formal@none@1@S@alpha 4 beta 1 ligation alone had no effect on transcription factor binding.@(((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x946.4.1) (:span 34 36)))\n (:nscopes ((:id . :x946.4.1) (:span 34 75)))\n (:identifiers (:sid . :s946.4) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008852@unknown@formal@none@1@S@The requirements for induction of transcription factors reflected the requirements for the secretion of multiple cytokines, including IL-2, TNF-alpha, IFN-gamma, and granulocyte macrophage-CSF.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "VBD") (:stem . "reflect") (:form . "reflected") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 82)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 149)\n  (:start . 140) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 177)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "macrophage-csf") (:form . "macrophage-CSF")\n  (:end . 192) (:start . 178) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s946.5) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008853@unknown@formal@none@1@S@In contrast to freshly isolated T cells, in vitro-cultured T cells did not require costimulation for cytokine secretion in response to anti-CD3 alone.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "vitro-cultured") (:form . "vitro-cultured")\n  (:end . 58) (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 96) (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x946.6.1) (:span 71 74)))\n (:nscopes ((:id . :x946.6.1) (:span 71 149)))\n (:identifiers (:sid . :s946.6) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008854@unknown@formal@none@1@S@Comparison of the dose response to anti-CD3 stimulation demonstrated that half-maximal induction of IL-2 was achieved using the same dose of anti-CD3 for both freshly isolated and cultured T cells.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "half-maximal") (:form . "half-maximal") (:end . 86)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 123) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 132) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 188)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s946.7) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008855@unknown@formal@none@1@S@Furthermore, the dose of OKT3 required to achieve half-maximal activation was the same using PMA or different concentrations of alpha 4 beta 1 ligands.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "OKT3") (:form . "OKT3") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "half-maximal") (:form . "half-maximal") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 124) (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s946.8) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008856@unknown@formal@none@1@S@Therefore, costimulation by alpha 4 beta 1 ligands was not due to stabilization of the interaction of the cells with its substrate.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 79) (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 130)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x946.9.1) (:span 55 58)))\n (:nscopes ((:id . :x946.9.1) (:span 55 130)))\n (:identifiers (:sid . :s946.9) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008857@unknown@formal@none@1@S@We conclude, rather, that alpha 4 beta 1 in freshly isolated T cells delivers a distinct signal that synergizes early with signals initiated by TCR/CD3 ligation to induce DNA binding of multiple transcription factors required for cytokine gene induction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 52))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 51)\n  (:start . 44) (:id . 53))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 60)\n  (:start . 52) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "deliver") (:form . "delivers") (:end . 77)\n  (:start . 69) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 88)\n  (:start . 80) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 95)\n  (:start . 89) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "synergize") (:form . "synergizes") (:end . 111)\n  (:start . 101) (:id . 62))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 140)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tcr/cd3") (:form . "TCR/CD3") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 160)\n  (:start . 152) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 170)\n  (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 182)\n  (:start . 175) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 194)\n  (:start . 186) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 208) (:start . 195) (:id . 76))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 216)\n  (:start . 209) (:id . 77))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 225)\n  (:start . 217) (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 229) (:start . 226)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 238)\n  (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 243) (:start . 239)\n  (:id . 81))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 253)\n  (:start . 244) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s946.10) (:did . :|8757316|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008858@unknown@formal@none@1@S@Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.@(((:tag . "NNP") (:stem . "Apoptosis") (:form . "Apoptosis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "precede") (:form . "preceded") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s947.1) (:did . :|8790371|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008860@unknown@formal@none@1@S@In contrast, a high level of bcl-2 protects cells in vitro and in vivo from the viral protease and prevents cell death following HIV infection of human lymphocytes, while reducing the yields of viral structural proteins, infectivity, and tumor necrosis factor alpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 70) (:start . 66)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 85) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 94)\n  (:start . 86) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 107)\n  (:start . 99) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 128)\n  (:start . 119) (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 142)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 163)\n  (:start . 152) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 170)\n  (:start . 165) (:id . 72))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 179)\n  (:start . 171) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "yield") (:form . "yields") (:end . 190)\n  (:start . 184) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 199)\n  (:start . 194) (:id . 77))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 210)\n  (:start . 200) (:id . 78))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 219)\n  (:start . 211) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 80))\n ((:tag . "NN") (:stem . "infectivity") (:form . "infectivity") (:end . 232)\n  (:start . 221) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 233) (:start . 232)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 237) (:start . 234)\n  (:id . 83))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 243)\n  (:start . 238) (:id . 84))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 252)\n  (:start . 244) (:id . 85))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 259)\n  (:start . 253) (:id . 86))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 265)\n  (:start . 260) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s947.3) (:did . :|8790371|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008861@unknown@formal@none@1@S@We present a model for HIV replication in which the viral protease depletes the infected cells of bcl-2, leading to oxidative stress-dependent activation of NF kappa B, a cellular factor required for HIV transcription, and ultimately to cell death.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "VBZ") (:stem . "deplete") (:form . "depletes") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "stress-dependent") (:form . "stress-dependent")\n  (:end . 142) (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 179)\n  (:start . 171) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 186)\n  (:start . 180) (:id . 73))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 195)\n  (:start . 187) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 199) (:start . 196)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 203) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 217) (:start . 204) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 79))\n ((:tag . "RB") (:stem . "ultimately") (:form . "ultimately") (:end . 233)\n  (:start . 223) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 236) (:start . 234)\n  (:id . 81))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 241) (:start . 237)\n  (:id . 82))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 247)\n  (:start . 242) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s947.4) (:did . :|8790371|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008862@unknown@formal@none@1@S@Purified bcl-2 is cleaved by HIV protease between phenylalanine 112 and alanine 113.@(((:tag . "VBN") (:stem . "purify") (:form . "Purified") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "cleave") (:form . "cleaved") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "phenylalanine") (:form . "phenylalanine")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "CD") (:stem . "112") (:form . "112") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alanine") (:form . "alanine") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "CD") (:stem . "113") (:form . "113") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s947.5) (:did . :|8790371|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008863@unknown@formal@none@1@S@The results suggest a new option for HIV gene therapy; bcl-2 muteins that have noncleavable alterations surrounding the HIV protease cleavage site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "option") (:form . "option") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mutein") (:form . "muteins") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "noncleavable") (:form . "noncleavable") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "VBG") (:stem . "surround") (:form . "surrounding") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protease") (:form . "protease") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x947.6.1) (:span 12 19)))\n (:hscopes ((:id . :x947.6.1) (:span 12 146)))\n (:identifiers (:sid . :s947.6) (:did . :|8790371|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008864@unknown@formal@none@1@S@Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lowered") (:form . "lowered") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s948.1) (:did . :|8796372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008865@unknown@formal@none@1@S@Transcription factor NF kappa B (nuclear factor kappa B) is induced in T lymphocytes from young individuals following activation with a variety of stimuli including anti-CD3, phorbol myristate acetate (PMA), and tumor necrosis factor-alpha (TNF-alpha).@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 84)\n  (:start . 73) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 107)\n  (:start . 96) (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 154)\n  (:start . 147) (:id . 67))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 164)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 173)\n  (:start . 165) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 192)\n  (:start . 183) (:id . 72))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 200)\n  (:start . 193) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 78))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 217)\n  (:start . 212) (:id . 79))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 226)\n  (:start . 218) (:id . 80))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 239)\n  (:start . 227) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 241) (:start . 240)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 250)\n  (:start . 241) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 251) (:start . 250)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s948.2) (:did . :|8796372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008866@unknown@formal@none@1@S@In contrast, activated T lymphocytes from older individuals show a significant reduction in the induction of NF kappa B in response to the same stimuli.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "old") (:form . "older") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s948.3) (:did . :|8796372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008867@unknown@formal@none@1@S@The age-related decline in induction of NF kappa B could not be attributed to alteration in the composition of subunits, p50 and p65 were found to be the predominant subunits of induced NF kappa B in T cells from young as well as elderly donors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 107)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 165)\n  (:start . 154) (:id . 71))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 174)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 185)\n  (:start . 178) (:id . 74))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 188) (:start . 186)\n  (:id . 75))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 194)\n  (:start . 189) (:id . 76))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 201) (:start . 200)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 207)\n  (:start . 202) (:id . 80))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 212) (:start . 208)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 218)\n  (:start . 213) (:id . 82))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 221) (:start . 219)\n  (:id . 83))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 226) (:start . 222)\n  (:id . 84))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 229) (:start . 227)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 237)\n  (:start . 230) (:id . 86))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 244)\n  (:start . 238) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 88)))@@@1@47@((:ncues ((:id . :x948.4.1) (:span 57 60)))\n (:nscopes ((:id . :x948.4.1) (:span 0 119)))\n (:identifiers (:sid . :s948.4) (:did . :|8796372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008868@unknown@formal@none@1@S@Furthermore, similar levels of NF kappa B were found in the cytosols of unactivated T cells from both young and elderly donors suggesting that precursor levels of NF kappa B remain unaltered during aging.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cytosol") (:form . "cytosols") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unactivated") (:form . "unactivated") (:end . 83)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 137)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 171)\n  (:start . 166) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 180)\n  (:start . 174) (:id . 73))\n ((:tag . "JJ") (:stem . "unaltered") (:form . "unaltered") (:end . 190)\n  (:start . 181) (:id . 74))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 197)\n  (:start . 191) (:id . 75))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 203)\n  (:start . 198) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x948.5.1) (:span 127 137)))\n (:hscopes ((:id . :x948.5.1) (:span 127 203)))\n (:identifiers (:sid . :s948.5) (:did . :|8796372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008870@unknown@formal@none@1@S@Interaction of HTLV-I Tax with the human proteasome: implications for NF-kappa B induction.@(((:tag . "NNP") (:stem . "Interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s949.1) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008871@unknown@formal@none@1@S@The human T-cell leukemia virus type I (HTLV-I) has been etiologically associated with the development of the adult T-cell leukemia (ATL) as well as degenerative neurologic syndrome termed tropical spastic paraparesis (TSP).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "RB") (:stem . "etiologically") (:form . "etiologically")\n  (:end . 70) (:start . 57) (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "degenerative") (:form . "degenerative") (:end . 161)\n  (:start . 149) (:id . 70))\n ((:tag . "JJ") (:stem . "neurologic") (:form . "neurologic") (:end . 172)\n  (:start . 162) (:id . 71))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 188)\n  (:start . 182) (:id . 73))\n ((:tag . "JJ") (:stem . "tropical") (:form . "tropical") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . "JJ") (:stem . "spastic") (:form . "spastic") (:end . 205)\n  (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "paraparesis") (:form . "paraparesis") (:end . 217)\n  (:start . 206) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "TSP") (:form . "TSP") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s949.2) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008872@unknown@formal@none@1@S@HTLV-I encodes a potent transactivator protein termed Tax that appears to play an important role in the process of T-cell immortalization.@(((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 53) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 137) (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x949.3.1) (:span 63 70)))\n (:hscopes ((:id . :x949.3.1) (:span 58 137)))\n (:identifiers (:sid . :s949.3) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008873@unknown@formal@none@1@S@Even though the mechanisms by which Tax induces transformation are still unknown, it seems likely that the ability of Tax to alter the expression of many cellular genes plays an important part in this process.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 62) (:start . 48) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 187)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 200) (:start . 196)\n  (:id . 76))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 208)\n  (:start . 201) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x949.4.1) (:span 91 97)) ((:id . :x949.4.2) (:span 85 90))\n  ((:id . :x949.4.3) (:span 73 80)))\n (:hscopes ((:id . :x949.4.1) (:span 91 208))\n  ((:id . :x949.4.2) (:span 85 208)) ((:id . :x949.4.3) (:span 12 80)))\n (:identifiers (:sid . :s949.4) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008874@unknown@formal@none@1@S@Tax does not bind directly to DNA but rather deregulates the activity of cellular transcription factors.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "VBZ") (:stem . "deregulate") (:form . "deregulates") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x949.5.1) (:span 9 12)))\n (:nscopes ((:id . :x949.5.1) (:span 9 33)))\n (:identifiers (:sid . :s949.5) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008875@unknown@formal@none@1@S@One family of host transcription factors whose activity is altered by Tax includes NF-kappa B/Rel.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s949.6) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008876@unknown@formal@none@1@S@These transcription factors are post-transcriptionally regulated by their assembly with a second family of inhibitory proteins termed I kappa B that serve to sequester the NF-kappa B/Rel complexes in the cytoplasm.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "post-transcriptionally")\n  (:form . "post-transcriptionally") (:end . 54) (:start . 32) (:id . 46))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 64)\n  (:start . 55) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 73)\n  (:start . 68) (:id . 49))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 82)\n  (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 96)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 103)\n  (:start . 97) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 126)\n  (:start . 118) (:id . 57))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 133)\n  (:start . 127) (:id . 58))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 135) (:start . 134)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 141)\n  (:start . 136) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "VB") (:stem . "sequester") (:form . "sequester") (:end . 167)\n  (:start . 158) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 180)\n  (:start . 172) (:id . 67))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 186)\n  (:start . 181) (:id . 68))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 213)\n  (:start . 204) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s949.7) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008877@unknown@formal@none@1@S@Upon cellular activation, I kappa B alpha is phosphorylated, polyubiquitinated, and degraded in the proteasome.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 59) (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "polyubiquitinate") (:form . "polyubiquitinated")\n  (:end . 78) (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s949.8) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008878@unknown@formal@none@1@S@This proteolytic event liberates NF-kappa B, permitting its rapid translocation into the nucleus where it binds to its cognate enhancer elements.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "liberate") (:form . "liberates") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "permit") (:form . "permitting") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 102)\n  (:start . 97) (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s949.9) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008880@unknown@formal@none@1@S@The mechanisms by which Tax activates NF-kappa B remain unclear, and findings presented in the literature are often controversial.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "controversial") (:form . "controversial")\n  (:end . 129) (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x949.11.1) (:span 56 63)))\n (:hscopes ((:id . :x949.11.1) (:span 0 63)))\n (:identifiers (:sid . :s949.11) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008881@unknown@formal@none@1@S@We identified a physical interaction between Tax and the HsN3 subunit of the human proteasome.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hsn3") (:form . "HsN3") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s949.12) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008882@unknown@formal@none@1@S@This raises the intriguing possibility that physical association of the HsN3 proteasome subunit with HTLV-I Tax coupled with the independent interaction of Tax with either p100 or p65-I kappa B alpha targets these cytoplasmic NF-kappa B/Rel complexes to the proteasome for processing.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intriguing") (:form . "intriguing") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hsn3") (:form . "HsN3") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 171)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p65-i") (:form . "p65-I") (:end . 185)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 191)\n  (:start . 186) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 193) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . "VBZ") (:stem . "target") (:form . "targets") (:end . 207)\n  (:start . 200) (:id . 73))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 213)\n  (:start . 208) (:id . 74))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 225)\n  (:start . 214) (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 234)\n  (:start . 226) (:id . 76))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 240)\n  (:start . 235) (:id . 77))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 250)\n  (:start . 241) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 253) (:start . 251)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 257) (:start . 254)\n  (:id . 80))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 268)\n  (:start . 258) (:id . 81))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 272) (:start . 269)\n  (:id . 82))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 283)\n  (:start . 273) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 284) (:start . 283)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x949.13.1) (:span 165 171 177 179))\n  ((:id . :x949.13.3) (:span 5 38)))\n (:hscopes ((:id . :x949.13.1) (:span 165 185))\n  ((:id . :x949.13.3) (:span 5 283)))\n (:identifiers (:sid . :s949.13) (:did . :|8797708|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008883@unknown@formal@none@1@S@Regulation of sialoadhesin expression on rat macrophages.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s950.1) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008884@unknown@formal@none@1@S@Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 28) (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 97) (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s950.2) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008885@unknown@formal@none@1@S@Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.@(((:tag . "NNP") (:stem . "Sialoadhesin") (:form . "Sialoadhesin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "macrophage-restricted")\n  (:form . "macrophage-restricted") (:end . 39) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 46)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s950.3) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008886@unknown@formal@none@1@S@It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subpopulation") (:form . "subpopulation")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s950.4) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008887@unknown@formal@none@1@S@We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 96) (:start . 81) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 121)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 168)\n  (:start . 157) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 191)\n  (:start . 181) (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "r2") (:form . "R2") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s950.5) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008888@unknown@formal@none@1@S@The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 75)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 88)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "themselves") (:form . "themselves") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "JJ") (:stem . "gc-mediated") (:form . "GC-mediated") (:end . 147)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 173)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x950.6.1) (:span 59 65)))\n (:nscopes ((:id . :x950.6.1) (:span 59 113)))\n (:identifiers (:sid . :s950.6) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008890@unknown@formal@none@1@S@Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 69) (:start . 56) (:id . 48))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 78)\n  (:start . 70) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x950.8.1) (:span 30 44)))\n (:hscopes ((:id . :x950.8.1) (:span 30 96)))\n (:identifiers (:sid . :s950.8) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008891@unknown@formal@none@1@S@Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cytokines/lps") (:form . "cytokines/LPS")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "gc-dependent") (:form . "GC-dependent") (:end . 114)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 126)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 142)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 168)\n  (:start . 160) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 183) (:start . 178)\n  (:id . 67))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 195)\n  (:start . 189) (:id . 69))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 210)\n  (:start . 201) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 218) (:start . 215)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s950.9) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008892@unknown@formal@none@1@S@Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reproduce") (:form . "reproduced") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 129) (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s950.10) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008893@unknown@formal@none@1@S@The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 103) (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 136)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 148)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 162)\n  (:start . 154) (:id . 66))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 174)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x950.11.1) (:span 79 82)))\n (:nscopes ((:id . :x950.11.1) (:span 79 112)))\n (:identifiers (:sid . :s950.11) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008894@unknown@formal@none@1@S@Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 27)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adrenal") (:form . "adrenal") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 131)\n  (:start . 119) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s950.12) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008895@unknown@formal@none@1@S@This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sialoadhesin") (:form . "sialoadhesin") (:end . 72)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 153)\n  (:start . 145) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cell-derived") (:form . "cell-derived") (:end . 169)\n  (:start . 157) (:id . 70))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 179)\n  (:start . 170) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 187) (:start . 184)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s950.13) (:did . :|8816424|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008896@unknown@formal@none@1@S@Selenium-mediated inhibition of transcription factor NF-kappa B and HIV-1 LTR promoter activity.@(((:tag . "JJ") (:stem . "selenium-mediated") (:form . "Selenium-mediated")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 28)\n  (:start . 18) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 61)\n  (:start . 53) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s951.1) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008897@unknown@formal@none@1@S@The eukaryotic transcription factor NF-kappa B is involved in the inducible expression of various inflammatory genes as well as in HIV-1 replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 110)\n  (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s951.2) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008898@unknown@formal@none@1@S@Activation of NF-kappa B is induced by prooxidants and several stimuli eliciting oxidative stress, such as cytokines, lipopolysaccharide, UV irradiation and other mediators.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "prooxidant") (:form . "prooxidants") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "VBG") (:stem . "elicit") (:form . "eliciting") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 136) (:start . 118) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s951.3) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008900@unknown@formal@none@1@S@In this study, we have investigated the effects of selenium, an integral component of glutathione peroxidase (GPX), on NF-kappa B activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "selenium") (:form . "selenium") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "integral") (:form . "integral") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "peroxidase") (:form . "peroxidase") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GPX") (:form . "GPX") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 127)\n  (:start . 119) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 140)\n  (:start . 130) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s951.5) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008901@unknown@formal@none@1@S@In selenium-deprived Jurkat and ESb-L T lymphocytes, supplementation of selenium led to a substantial increase of GPX activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "selenium-deprived") (:form . "selenium-deprived")\n  (:end . 20) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ESb-L") (:form . "ESb-L") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "supplementation") (:form . "supplementation")\n  (:end . 68) (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "selenium") (:form . "selenium") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GPX") (:form . "GPX") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s951.6) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008902@unknown@formal@none@1@S@Analysis of DNA binding revealed that NF-kappa B activation in response to TNF was significantly inhibited under these conditions.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s951.7) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008903@unknown@formal@none@1@S@Likewise, reporter gene assays using luciferase constructs driven by the HIV-1 long terminal repeat showed a dose-dependent inhibition of NF-kappa B controlled gene expression by selenium.@(((:tag . "RB") (:stem . "likewise") (:form . "Likewise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 123) (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "controlled") (:form . "controlled") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "selenium") (:form . "selenium") (:end . 187)\n  (:start . 179) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s951.8) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008904@unknown@formal@none@1@S@The effects of selenium were specific for NF-kappa B, since the activity of the transcription factor AP-1 was not suppressed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "selenium") (:form . "selenium") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x951.9.1) (:span 110 113)))\n (:nscopes ((:id . :x951.9.1) (:span 60 124)))\n (:identifiers (:sid . :s951.9) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008905@unknown@formal@none@1@S@These data suggest that selenium supplementation may be used to modulate the expression of NF-kappa B target genes and HIV-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "selenium") (:form . "selenium") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "supplementation") (:form . "supplementation")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x951.10.1) (:span 49 52))\n  ((:id . :x951.10.2) (:span 11 18)))\n (:hscopes ((:id . :x951.10.1) (:span 49 124))\n  ((:id . :x951.10.2) (:span 11 124)))\n (:identifiers (:sid . :s951.10) (:did . :|8852698|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008906@unknown@formal@none@1@S@Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 39) (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 50)\n  (:start . 40) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 63)\n  (:start . 54) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anthracycline-induced")\n  (:form . "anthracycline-induced") (:end . 104) (:start . 83) (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 120) (:start . 105) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 129)\n  (:start . 124) (:id . 54))\n ((:tag . "JJ") (:stem . "erythroleukemic") (:form . "erythroleukemic")\n  (:end . 145) (:start . 130) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s952.1) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008907@unknown@formal@none@1@S@Aclacinomycin (ACLA) and doxorubicin (DOX) were used at subtoxic concentrations to induce erythroid differentiation in the human leukemic cell line K562.@(((:tag . "NNP") (:stem . "Aclacinomycin") (:form . "Aclacinomycin")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ACLA") (:form . "ACLA") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "doxorubicin") (:form . "doxorubicin") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DOX") (:form . "DOX") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subtoxic") (:form . "subtoxic") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 79) (:start . 65) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 115) (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s952.2) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008908@unknown@formal@none@1@S@Cell hemoglobinization was accompanied by the increased expression of genes encoding gamma-globin and porphobilinogen deaminase (PBGD), an enzyme of heme synthesis.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hemoglobinization") (:form . "hemoglobinization")\n  (:end . 22) (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 38)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 97)\n  (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "porphobilinogen") (:form . "porphobilinogen")\n  (:end . 117) (:start . 102) (:id . 55))\n ((:tag . "NNP") (:stem . "deaminase") (:form . "deaminase") (:end . 127)\n  (:start . 118) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PBGD") (:form . "PBGD") (:end . 133) (:start . 129)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "heme") (:form . "heme") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s952.3) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008910@unknown@formal@none@1@S@In contrast, in DOX-treated cells, the transcription rate of these genes was unchanged in comparison with control cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dox-treated") (:form . "DOX-treated") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s952.5) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008911@unknown@formal@none@1@S@In addition, inhibition of mRNA synthesis with actinomycin D indicated that DOX induced an increased stability of PBGD and GATA-1 mRNAs, whereas ACLA did not affect the half-lives of these mRNAs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DOX") (:form . "DOX") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PBGD") (:form . "PBGD") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NNP") (:stem . "ACLA") (:form . "ACLA") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "half-live") (:form . "half-lives") (:end . 179)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 188)\n  (:start . 183) (:id . 73))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 194)\n  (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x952.6.2) (:span 61 75)))\n (:ncues ((:id . :x952.6.1) (:span 154 157)))\n (:hscopes ((:id . :x952.6.2) (:span 61 135)))\n (:nscopes ((:id . :x952.6.1) (:span 154 194)))\n (:identifiers (:sid . :s952.6) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008912@unknown@formal@none@1@S@Because the increase in erythroid mRNA steady-state level in anthracycline-treated cells was inhibited by cycloheximide, this suggests that transcriptional activation in ACLA-treated cells and mRNA stabilization in DOX-treated cells were dependent on de novo protein synthesis.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anthracycline-treated")\n  (:form . "anthracycline-treated") (:end . 82) (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 119) (:start . 106) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 134)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 139) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 155) (:start . 140) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 166)\n  (:start . 156) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "acla-treated") (:form . "ACLA-treated") (:end . 182)\n  (:start . 170) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 188)\n  (:start . 183) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 197) (:start . 193)\n  (:id . 67))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 211) (:start . 198) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "dox-treated") (:form . "DOX-treated") (:end . 226)\n  (:start . 215) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 232)\n  (:start . 227) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 237) (:start . 233)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 247)\n  (:start . 238) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 250) (:start . 248)\n  (:id . 74))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 253) (:start . 251)\n  (:id . 75))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 258) (:start . 254)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 266)\n  (:start . 259) (:id . 77))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 276)\n  (:start . 267) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x952.7.1) (:span 126 134)))\n (:hscopes ((:id . :x952.7.1) (:span 126 276)))\n (:identifiers (:sid . :s952.7) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008913@unknown@formal@none@1@S@Finally, GATA-1 protein level was shown to be increased in ACLA-treated but not in DOX-treated cells.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acla-treated") (:form . "ACLA-treated") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dox-treated") (:form . "DOX-treated") (:end . 94)\n  (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x952.8.1) (:span 76 79)))\n (:nscopes ((:id . :x952.8.1) (:span 76 100)))\n (:identifiers (:sid . :s952.8) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008914@unknown@formal@none@1@S@These two anthracyclines, although closely related in their structures, appeared to act as differentiation inducers by distinct mechanisms.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "anthracycline") (:form . "anthracyclines")\n  (:end . 24) (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 59)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 106) (:start . 91) (:id . 57))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x952.9.1) (:span 72 80)))\n (:hscopes ((:id . :x952.9.1) (:span 0 138)))\n (:identifiers (:sid . :s952.9) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008915@unknown@formal@none@1@S@Indeed, erythroid gene expression was demonstrated to be regulated transcriptionally by ACLA and mainly posttranscriptionally by DOX.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 50)\n  (:start . 38) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 84) (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ACLA") (:form . "ACLA") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 103)\n  (:start . 97) (:id . 56))\n ((:tag . "RB") (:stem . "posttranscriptionally")\n  (:form . "posttranscriptionally") (:end . 125) (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DOX") (:form . "DOX") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s952.10) (:did . :|8853898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008916@unknown@formal@none@1@S@Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "AP)-1") (:form . "AP)-1") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 118) (:start . 98) (:id . 56))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 127)\n  (:start . 119) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 138)\n  (:start . 132) (:id . 59))\n ((:tag . "NN") (:stem . "sphingomyelinase") (:form . "sphingomyelinase")\n  (:end . 155) (:start . 139) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 163)\n  (:start . 156) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s953.1) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008917@unknown@formal@none@1@S@A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "obstacle") (:form . "obstacle") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "understand") (:form . "understanding") (:end . 33)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "VBZ") (:stem . "arise") (:form . "arises") (:end . 96)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "costimulus") (:form . "costimulus") (:end . 141)\n  (:start . 131) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 159)\n  (:start . 149) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 180)\n  (:start . 171) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 190)\n  (:start . 184) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 203)\n  (:start . 195) (:id . 75))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 216)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 224) (:start . 220)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 232)\n  (:start . 225) (:id . 79))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 235) (:start . 233)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 244)\n  (:start . 236) (:id . 81))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 249) (:start . 245)\n  (:id . 82))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 255)\n  (:start . 250) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 258) (:start . 256)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 262) (:start . 259)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 266) (:start . 263)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s953.2) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008918@unknown@formal@none@1@S@To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "overcome") (:form . "overcome") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "exploit") (:form . "exploited") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "blast") (:form . "blasts") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . 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"of") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "antigenic") (:form . "antigenic") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 180)\n  (:start . 171) (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 181) (:start . 180)\n  (:id . 72))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 186) (:start . 182)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 190) (:start . 188)\n  (:id . 75))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 195) (:start . 191)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 200) (:start . 196)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 205) (:start . 201)\n  (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 79))\n ((:tag . "VB") (:stem . "observe") (:form . "observe") (:end . 216)\n  (:start . 209) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 81))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 229)\n  (:start . 221) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 239)\n  (:start . 233) (:id . 84))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 241) (:start . 240)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 247)\n  (:start . 242) (:id . 86))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 250) (:start . 248)\n  (:id . 87))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 255) (:start . 251)\n  (:id . 88))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 266)\n  (:start . 256) (:id . 89))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 269) (:start . 267)\n  (:id . 90))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 279)\n  (:start . 270) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 92)))@@@1@51@((:ncues ((:id . :x953.3.1) (:span 150 157)))\n (:nscopes ((:id . :x953.3.1) (:span 150 180)))\n (:identifiers (:sid . :s953.3) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008920@unknown@formal@none@1@S@However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b7") (:form . "B7") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 92)\n  (:start . 81) (:id . 53))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 115)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 158) (:start . 145) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 180)\n  (:start . 171) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 189) (:start . 186)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 195)\n  (:start . 190) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x953.5.1) (:span 186 189)))\n (:nscopes ((:id . :x953.5.1) (:span 186 195)))\n (:identifiers (:sid . :s953.5) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008921@unknown@formal@none@1@S@In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mhc/superantigen") (:form . "MHC/superantigen")\n  (:end . 63) (:start . 47) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 158)\n  (:start . 149) (:id . 71))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 161) (:start . 159)\n  (:id . 72))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 166) (:start . 162)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 169) (:start . 167)\n  (:id . 74))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 174) (:start . 170)\n  (:id . 75))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 185)\n  (:start . 175) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x953.6.1) (:span 80 87)))\n (:nscopes ((:id . :x953.6.1) (:span 80 101)))\n (:identifiers (:sid . :s953.6) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008922@unknown@formal@none@1@S@Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cd28-mediated") (:form . "CD28-mediated")\n  (:end . 96) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s953.7) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008923@unknown@formal@none@1@S@This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chloroquine") (:form . "chloroquine") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "sphingomyelinase") (:form . "sphingomyelinase")\n  (:end . 109) (:start . 93) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 146) (:start . 126) (:id . 62))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 155)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 165)\n  (:start . 156) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "wortmannin") (:form . "wortmannin") (:end . 177)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x953.8.1) (:span 115 118)))\n (:nscopes ((:id . :x953.8.1) (:span 115 177)))\n (:identifiers (:sid . :s953.8) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008924@unknown@formal@none@1@S@In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "wortmannin") (:form . "wortmannin") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "variably") (:form . "variably") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chloroquine") (:form . "chloroquine") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s953.9) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008925@unknown@formal@none@1@S@These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd28-derived") (:form . "CD28-derived") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 152)\n  (:start . 142) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 176)\n  (:start . 168) (:id . 70))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 186) (:start . 182)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . "NN") (:stem . "sphingomyelinase") (:form . "sphingomyelinase")\n  (:end . 210) (:start . 194) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 235) (:start . 215) (:id . 76))\n ((:tag . "JJ") (:stem . "3-kinase-linked") (:form . "3-kinase-linked")\n  (:end . 251) (:start . 236) (:id . 77))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 260)\n  (:start . 252) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x953.10.1) (:span 11 18)))\n (:hscopes ((:id . :x953.10.1) (:span 11 260)))\n (:identifiers (:sid . :s953.10) (:did . :|8871623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008926@unknown@formal@none@1@S@Second messenger up-regulation of androgen receptor gene transcription is absent in androgen insensitive human prostatic carcinoma cell lines, PC-3 and DU-145.@(((:tag . "JJ") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "JJ") (:stem . "insensitive") (:form . "insensitive") (:end . 104)\n  (:start . 93) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 55))\n ((:tag . "JJ") (:stem . "prostatic") (:form . "prostatic") (:end . 120)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 130)\n  (:start . 121) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 141)\n  (:start . 136) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PC-3") (:form . "PC-3") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DU-145") (:form . "DU-145") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x954.1.1) (:span 74 80)))\n (:nscopes ((:id . :x954.1.1) (:span 0 158)))\n (:identifiers (:sid . :s954.1) (:did . :|8925904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008927@unknown@formal@none@1@S@A theoretical pathway of transcriptional regulation of the androgen receptor (AR) gene is via a cAMP response element (CRE) present in its promoter region (-508 to -501).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "theoretical") (:form . "theoretical") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AR") (:form . "AR") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 131)\n  (:start . 124) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 147)\n  (:start . 139) (:id . 68))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 154)\n  (:start . 148) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "CD") (:stem . "-508") (:form . "-508") (:end . 160) (:start . 156)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 72))\n ((:tag . "CD") (:stem . "-501") (:form . "-501") (:end . 168) (:start . 164)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s954.2) (:did . :|8925904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008928@unknown@formal@none@1@S@After 20 h of stimulation with 8-bromo-cAMP, AR mRNA was upregulated in LNCaP but not in either PC-3 or DU-145 cell lines.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 25)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "8-bromo-cAMP") (:form . "8-bromo-cAMP") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "AR") (:form . "AR") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LNCaP") (:form . "LNCaP") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "NNP") (:stem . "PC-3") (:form . "PC-3") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "DU-145") (:form . "DU-145") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x954.3.1) (:span 82 85)))\n (:nscopes ((:id . :x954.3.1) (:span 82 121)))\n (:identifiers (:sid . :s954.3) (:did . :|8925904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008930@unknown@formal@none@1@S@The ability to regulate AR gene transcription via the second messenger pathway is lost in the PC-3 and DU-145 cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "ar") (:form . "AR") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PC-3") (:form . "PC-3") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DU-145") (:form . "DU-145") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s954.5) (:did . :|8925904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008931@unknown@formal@none@1@S@This may be an important primary mechanism of androgen insensitivity in prostate cancer.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "androgen") (:form . "androgen") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "prostate") (:form . "prostate") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x954.6.1) (:span 5 8)))\n (:hscopes ((:id . :x954.6.1) (:span 5 87)))\n (:identifiers (:sid . :s954.6) (:did . :|8925904|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008932@unknown@formal@none@1@S@A novel immunosuppressive factor in bovine colostrum blocks activation of the interleukin 2 gene enhancer at the NFAT site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 25) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "colostrum") (:form . "colostrum") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s955.1) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008933@unknown@formal@none@1@S@A factor in bovine colostrum (colostrum inhibitory factor, CIF) inhibits interleukin 2 (IL2) production in activated T helper cells by blocking the accumulation of IL2 mRNA.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "colostrum") (:form . "colostrum") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "colostrum") (:form . "colostrum") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CIF") (:form . "CIF") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 103)\n  (:start . 93) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 116)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 160)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IL2") (:form . "IL2") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s955.2) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008934@unknown@formal@none@1@S@To determine whether CIF blocks at the level of IL2 transcription, we introduced reporter plasmids into the human T leukemia cell line Jurkat by transient transfection.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "cif") (:form . "CIF") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "block") (:form . "blocks") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "introduce") (:form . "introduced") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "jurkat") (:form . "Jurkat") (:end . 141)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 154)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 167)\n  (:start . 155) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x955.3.1) (:span 13 20)))\n (:hscopes ((:id . :x955.3.1) (:span 13 65)))\n (:identifiers (:sid . :s955.3) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008935@unknown@formal@none@1@S@These contained the luciferase gene under the control of either the human IL2 upstream enhancer region (segments -326 to +45) or three repeats of the NFAT element contained within it (segments -255 to -285).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il2") (:form . "IL2") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "CD") (:stem . "-326") (:form . "-326") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "CD") (:stem . "+45") (:form . "+45") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 162)\n  (:start . 155) (:id . 70))\n ((:tag . "VBN") (:stem . "contain") (:form . "contained") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 179)\n  (:start . 173) (:id . 72))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 192)\n  (:start . 184) (:id . 75))\n ((:tag . "CD") (:stem . "-255") (:form . "-255") (:end . 197) (:start . 193)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "CD") (:stem . "-285") (:form . "-285") (:end . 205) (:start . 201)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s955.4) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008936@unknown@formal@none@1@S@Expression of luciferase in these cells was induced by phorbol myristate acetate plus a calcium ionophore.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "ionophore") (:form . "ionophore") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s955.5) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008937@unknown@formal@none@1@S@CIF inhibited induction of either construct as did cyclosporine, which is known to block activation of the NFAT element.@(((:tag . "NNP") (:stem . "CIF") (:form . "CIF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s955.6) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008938@unknown@formal@none@1@S@CIF failed to inhibit several other enhancer elements.@(((:tag . "NNP") (:stem . "CIF") (:form . "CIF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 50)))@@@1@9@((:ncues ((:id . :x955.7.1) (:span 4 10)))\n (:nscopes ((:id . :x955.7.1) (:span 4 53)))\n (:identifiers (:sid . :s955.7) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008940@unknown@formal@none@1@S@Stably transfected Jurkat cells behaved similarly to the transiently transfected ones with respect to inhibition by CIF and cyclosporine.@(((:tag . "RB") (:stem . "stably") (:form . "Stably") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "behave") (:form . "behaved") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CIF") (:form . "CIF") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cyclosporine") (:form . "cyclosporine") (:end . 136)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s955.9) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008941@unknown@formal@none@1@S@The NFAT-luc assay is a useful technique for the rapid, sensitive measurement of CIF or other immunosuppressants with a similar mode of action.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NFAT-luc") (:form . "NFAT-luc") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "measurement") (:form . "measurement") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CIF") (:form . "CIF") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 112) (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s955.10) (:did . :|8960365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008942@unknown@formal@none@1@S@The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "determine") (:form . "determines") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s956.1) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008943@unknown@formal@none@1@S@The molecular mechanisms of the effects of IL-4 and IL-13 on HIV infection in human monocytes as they matured into monocyte-derived macrophages over 7 days were investigated using HIV-1(BaL), and low passage clinical strains.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "mature") (:form . "matured") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 131) (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 143)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 173)\n  (:start . 161) (:id . 68))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 179) (:start . 174)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "HIV-1(BaL)") (:form . "HIV-1(BaL)") (:end . 190)\n  (:start . 180) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "NN") (:stem . "passage") (:form . "passage") (:end . 207)\n  (:start . 200) (:id . 74))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 216)\n  (:start . 208) (:id . 75))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 224)\n  (:start . 217) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s956.2) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008944@unknown@formal@none@1@S@IL-4 and IL-13 up-regulated the expression of both genomic and spliced HIV mRNA in monocytes cultured on Teflon, as determined by Northern analysis and p24 Ag assay.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "up-regulate") (:form . "up-regulated") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "splice") (:form . "spliced") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Teflon") (:form . "Teflon") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "northern") (:form . "Northern") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s956.3) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008945@unknown@formal@none@1@S@Using a nuclear run-on assay, IL-4 stimulation was shown to enhance transcription by two- to threefold.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two-") (:form . "two-") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "RB") (:stem . "threefold") (:form . "threefold") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s956.4) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008946@unknown@formal@none@1@S@IL-4 stimulated nuclear factor-kappaB nuclear translocation and binding before enhancement of HIV RNA expression.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 37) (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 45)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 59) (:start . 46) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 78)\n  (:start . 72) (:id . 50))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 90)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 97) (:start . 94)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s956.5) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008947@unknown@formal@none@1@S@Conversely, IL-4 and IL-13 markedly and significantly inhibited HIV replication at the transcriptional level in monocyte-derived macrophages, and this occurred whether these cytokines were added before or after HIV infection.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 53) (:start . 40) (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 102) (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 128) (:start . 112) (:id . 58))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 140)\n  (:start . 129) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 167)\n  (:start . 160) (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 173)\n  (:start . 168) (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 183)\n  (:start . 174) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 188) (:start . 184)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 194) (:start . 189)\n  (:id . 68))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 201)\n  (:start . 195) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 204) (:start . 202)\n  (:id . 70))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 210)\n  (:start . 205) (:id . 71))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 214) (:start . 211)\n  (:id . 72))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 224)\n  (:start . 215) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s956.6) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008948@unknown@formal@none@1@S@The reversal from stimulation to inhibition occurred after 3 to 5 days of adherence to plastic.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reversal") (:form . "reversal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "plastic") (:form . "plastic") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s956.7) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008950@unknown@formal@none@1@S@The effect of both cytokines on the monocyte maturation/differentiation (CD11b, CD13, and CD26) and other macrophage markers (CD14 and CD68) was examined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "maturation/differentiation")\n  (:form . "maturation/differentiation") (:end . 71) (:start . 45) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD13") (:form . "CD13") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD26") (:form . "CD26") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cd68") (:form . "CD68") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 153)\n  (:start . 145) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s956.9) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008951@unknown@formal@none@1@S@IL-4 enhanced CD11b, but inhibited CD26 expression and delayed CD13 loss.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "cd26") (:form . "CD26") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "cd13") (:form . "CD13") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s956.10) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008952@unknown@formal@none@1@S@IL-13 had similar effects on CD11b and CD13, but no effect on CD26.@(((:tag . "NN") (:stem . "il-13") (:form . "IL-13") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD13") (:form . "CD13") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD26") (:form . "CD26") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x956.11.1) (:span 49 51)))\n (:nscopes ((:id . :x956.11.1) (:span 49 66)))\n (:identifiers (:sid . :s956.11) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008953@unknown@formal@none@1@S@Hence, these cytokines do not simply enhance monocyte differentiation, but have complex and slightly divergent effects that impact on HIV replication probably through cell signaling pathways and nuclear factor-kappaB translocation.@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 69) (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "impact") (:form . "impact") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 149)\n  (:start . 138) (:id . 64))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 190)\n  (:start . 182) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 202)\n  (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 216) (:start . 203) (:id . 72))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 230) (:start . 217) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x956.12.1) (:span 150 158)))\n (:hscopes ((:id . :x956.12.1) (:span 150 230)))\n (:identifiers (:sid . :s956.12) (:did . :|8977228|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008954@unknown@formal@none@1@S@Engagement of the Lewis X antigen (CD15) results in monocyte activation.@(((:tag . "NN") (:stem . "engagement") (:form . "Engagement") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Lewis") (:form . "Lewis") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd15") (:form . "CD15") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s957.1) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008955@unknown@formal@none@1@S@We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "TNF-alpha)-treated") (:form . "TNF-alpha)-treated")\n  (:end . 96) (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 108)\n  (:start . 97) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 55))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 124)\n  (:start . 115) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 145)\n  (:start . 139) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 152)\n  (:start . 146) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd36") (:form . "CD36") (:end . 161) (:start . 157)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 174)\n  (:start . 165) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s957.2) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008956@unknown@formal@none@1@S@Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 33) (:start . 20) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD15") (:form . "CD15") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Lewis") (:form . "Lewis") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "counter-receptor") (:form . "counter-receptor")\n  (:end . 143) (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 159)\n  (:start . 148) (:id . 67))\n ((:tag . "NNS") (:stem . "selectin") (:form . "selectins") (:end . 169)\n  (:start . 160) (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 185)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 193) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 202)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x957.3.1) (:span 170 173)))\n (:hscopes ((:id . :x957.3.1) (:span 170 202)))\n (:identifiers (:sid . :s957.3) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008957@unknown@formal@none@1@S@We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "readout") (:form . "readout") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd15") (:form . "CD15") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 98) (:start . 85) (:id . 56))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 156)\n  (:start . 147) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 190) (:start . 186)\n  (:id . 69))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 195) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mm6") (:form . "MM6") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s957.4) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008958@unknown@formal@none@1@S@Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.@(((:tag . "JJ") (:stem . "quantitative") (:form . "Quantitative") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 45) (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 51) (:start . 46)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 60)\n  (:start . 52) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 68)\n  (:start . 62) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 76) (:start . 70)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 104)\n  (:start . 92) (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 114)\n  (:start . 105) (:id . 55))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 119) (:start . 115)\n  (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 125)\n  (:start . 120) (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 127) (:start . 126)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 138)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 155) (:start . 142) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s957.5) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008960@unknown@formal@none@1@S@To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd15") (:form . "CD15") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter/enhancer") (:form . "promoter/enhancer")\n  (:end . 147) (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 157)\n  (:start . 148) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 161) (:start . 158)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 172)\n  (:start . 162) (:id . 64))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 177) (:start . 173)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MM6") (:form . "MM6") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s957.7) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008961@unknown@formal@none@1@S@Subsequent cross-linking of CD15 increased CAT activity.@(((:tag . "JJ") (:stem . "subsequent") (:form . "Subsequent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 24) (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CD15") (:form . "CD15") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s957.8) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008962@unknown@formal@none@1@S@CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.@(((:tag . "NNP") (:stem . "CD15") (:form . "CD15") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 102) (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD15") (:form . "CD15") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 155) (:start . 136) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 163)\n  (:start . 156) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s957.9) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008963@unknown@formal@none@1@S@Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-cd15") (:form . "anti-CD15") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "cross-linked") (:form . "cross-linked") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 61)\n  (:start . 49) (:id . 48))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 77)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 117)\n  (:start . 108) (:id . 55))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 127)\n  (:start . 118) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 57))\n ((:tag . "RB") (:stem . "minimally") (:form . "minimally") (:end . 138)\n  (:start . 129) (:id . 58))\n ((:tag . "VBD") (:stem . "change") (:form . "changed") (:end . 146)\n  (:start . 139) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 154)\n  (:start . 147) (:id . 60))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 167)\n  (:start . 155) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 178) (:start . 175)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 182) (:start . 179)\n  (:id . 66))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 189)\n  (:start . 183) (:id . 67))\n ((:tag . "NN") (:stem . "sv40") (:form . "SV40") (:end . 194) (:start . 190)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 203)\n  (:start . 195) (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 212)\n  (:start . 204) (:id . 70))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 222)\n  (:start . 213) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x957.10.1) (:span 179 182)))\n (:nscopes ((:id . :x957.10.1) (:span 179 222)))\n (:identifiers (:sid . :s957.10) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008964@unknown@formal@none@1@S@We conclude that engagement of CD15 on monocytes results in monocyte activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd15") (:form . "CD15") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s957.11) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008965@unknown@formal@none@1@S@In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "well-recognized") (:form . "well-recognized")\n  (:end . 34) (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "adhesive") (:form . "adhesive") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD15") (:form . "CD15") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "initiate") (:form . "initiating") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 140) (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 147)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "come") (:form . "come") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 175) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 198)\n  (:start . 189) (:id . 70))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 210)\n  (:start . 199) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x957.12.1) (:span 55 58)))\n (:hscopes ((:id . :x957.12.1) (:span 55 210)))\n (:identifiers (:sid . :s957.12) (:did . :|8978306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008966@unknown@formal@none@1@S@V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth [published erratum appears in AIDS Res Hum Retroviruses 1997 May 1;13(7):633]@(((:tag . "NN") (:stem . "v3") (:form . "V3") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 33) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "2-induced") (:form . "2-induced") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "erratum") (:form . "erratum") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Res") (:form . "Res") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Hum") (:form . "Hum") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Retroviruses") (:form . "Retroviruses")\n  (:end . 149) (:start . 137) (:id . 64))\n ((:tag . "CD") (:stem . "1997") (:form . "1997") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "May") (:form . "May") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "CD") (:stem . "1;13(7):633") (:form . "1;13(7):633") (:end . 170)\n  (:start . 159) (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 171) (:start . 170)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s958.1) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008967@unknown@formal@none@1@S@We tested the effect of three linear or two loop peptides derived from the V3 region of the HTLV-III BH10 clone or the SF2 strain of human immunodeficiency virus type 1 on IL-2-driven T cell proliferation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "v3") (:form . "V3") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-III") (:form . "HTLV-III") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "NNP") (:stem . "BH10") (:form . "BH10") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sf2") (:form . "SF2") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 129)\n  (:start . 123) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 68))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 155) (:start . 139) (:id . 69))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 161)\n  (:start . 156) (:id . 70))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 166) (:start . 162)\n  (:id . 71))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "il-2-driven") (:form . "IL-2-driven") (:end . 183)\n  (:start . 172) (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 204) (:start . 191) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s958.2) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008968@unknown@formal@none@1@S@V3-BH10, which consists of 42 amino acids and has a loop structure, suppressed IL-2-driven proliferation of all IL-2-dependent cells [Kit225, ED-40515(+), KT-3, 7-day PHA-blasts, and fresh peripheral blood mononuclear cells] tested, whereas it did not suppress the cell growth of IL-2-independent cell lines (Hut102, Molt-4, and Jurkat).@(((:tag . "NNP") (:stem . "V3-BH10") (:form . "V3-BH10") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . 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5008970@unknown@formal@none@1@S@The treatment with anti-V3 loop monoclonal antibody (902 antibody) completely abolished the suppressive effect of V3-BH10.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-v3") (:form . "anti-V3") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "CD") (:stem . "902") (:form . "902") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "V3-BH10") (:form . "V3-BH10") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s958.5) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008971@unknown@formal@none@1@S@In addition, V3-BH10 generated the arrest of Kit225 cells and also purified CD8-positive lymphocytes in G1 phase in the presence of IL-2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "V3-BH10") (:form . "V3-BH10") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kit225") (:form . "Kit225") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "cd8-positive") (:form . "CD8-positive") (:end . 88)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s958.6) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008972@unknown@formal@none@1@S@Neither chromatin condensation nor DNA fragmentation was detected in Kit225 cells cultured with V3-BH10 and IL-2.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "condensation") (:form . "condensation") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kit225") (:form . "Kit225") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "V3-BH10") (:form . "V3-BH10") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x958.7.1) (:span 0 7 31 34)))\n (:nscopes ((:id . :x958.7.1) (:span 0 112)))\n (:identifiers (:sid . :s958.7) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5008974@unknown@formal@none@1@S@However, V3-BH10 enhanced IL-2-induced mRNA expression of c-fos but not c-myc or junB.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "V3-BH10") (:form . "V3-BH10") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "junb") (:form . "junB") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x958.9.1) (:span 68 71)))\n (:nscopes ((:id . :x958.9.1) (:span 68 85)))\n (:identifiers (:sid . :s958.9) (:did . :|9007200|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5008976@unknown@formal@none@1@S@Nuclear factor-kappaB activation in human monocytes stimulated with lipopolysaccharide is inhibited by fibroblast conditioned medium and exogenous PGE2.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 86) (:start . 68) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 99)\n  (:start . 90) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 113)\n  (:start . 103) (:id . 54))\n ((:tag . "JJ") (:stem . "conditioned") (:form . "conditioned") (:end . 125)\n  (:start . 114) (:id . 55))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 132)\n  (:start . 126) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 146)\n  (:start . 137) (:id . 58))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 151) (:start . 147)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s959.1) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008977@unknown@formal@none@1@S@The nuclear factor kappaB (NF-kappaB) is thought to be crucially involved in the gene activation of several cytokines, including tumor necrosis factor alpha (TNF).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "crucially") (:form . "crucially") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 150)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x959.2.1) (:span 41 48)))\n (:hscopes ((:id . :x959.2.1) (:span 0 162)))\n (:identifiers (:sid . :s959.2) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008978@unknown@formal@none@1@S@Previously, we showed that fibroblast conditioned medium (FCM) is able to inhibit both TNF mRNA accumulation and protein release in peripheral blood-derived human monocytes (PBM) stimulated with lipopolysaccharide (LPS).@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 21) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "conditioned") (:form . "conditioned") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FCM") (:form . "FCM") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 108)\n  (:start . 96) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 142)\n  (:start . 132) (:id . 65))\n ((:tag . "JJ") (:stem . "blood-derived") (:form . "blood-derived")\n  (:end . 156) (:start . 143) (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 172)\n  (:start . 163) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PBM") (:form . "PBM") (:end . 177) (:start . 174)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 189)\n  (:start . 179) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 213) (:start . 195) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 215) (:start . 214)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 218) (:start . 215)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 219) (:start . 218)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s959.3) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008980@unknown@formal@none@1@S@We provide evidence that FCM strongly inhibits the LPS-induced NF-kappaB activation in PBM.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "FCM") (:form . "FCM") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBM") (:form . "PBM") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s959.5) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008981@unknown@formal@none@1@S@Furthermore, we show that exogenous PGE2 mimics the NF-kappaB inhibitory effect of FCM.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "mimic") (:form . "mimics") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "FCM") (:form . "FCM") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s959.6) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008982@unknown@formal@none@1@S@On the other hand, FCM produced in the presence of indomethacin does not inhibit NF-kappaB activation by LPS.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FCM") (:form . "FCM") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 63)\n  (:start . 51) (:id . 53))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x959.7.1) (:span 69 72)))\n (:nscopes ((:id . :x959.7.1) (:span 69 108)))\n (:identifiers (:sid . :s959.7) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008983@unknown@formal@none@1@S@Our results lend further support to the hypothesis that inflammatory and immune responses of monocytes/macrophages may be modulated at the molecular level by signals originating from tissue structural cells such as fibroblasts.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "lend") (:form . "lend") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 114) (:start . 93) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 165)\n  (:start . 158) (:id . 65))\n ((:tag . "VBG") (:stem . "originate") (:form . "originating") (:end . 177)\n  (:start . 166) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 182) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 189)\n  (:start . 183) (:id . 68))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 200)\n  (:start . 190) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 206)\n  (:start . 201) (:id . 70))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 211) (:start . 207)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 214) (:start . 212)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 226)\n  (:start . 215) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x959.8.1) (:span 115 118))\n  ((:id . :x959.8.2) (:span 40 50)))\n (:hscopes ((:id . :x959.8.1) (:span 115 226))\n  ((:id . :x959.8.2) (:span 40 226)))\n (:identifiers (:sid . :s959.8) (:did . :|9009221|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008984@unknown@formal@none@1@S@Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.@(((:tag . "JJ") (:stem . "glycation-dependent")\n  (:form . "Glycation-dependent") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "species-mediated") (:form . "species-mediated")\n  (:end . 53) (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 65)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 80)\n  (:start . 73) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hit") (:form . "HIT") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s960.1) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008985@unknown@formal@none@1@S@Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a decrease in the insulin content of the cells.@(((:tag . "VBN") (:stem . "prolong") (:form . "Prolonged") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "glycemic") (:form . "glycemic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "non-insulin-dependent")\n  (:form . "non-insulin-dependent") (:end . 56) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "diabetes") (:form . "diabetes") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "mellitus") (:form . "mellitus") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 83)\n  (:start . 75) (:id . 50))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 89) (:start . 84)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 95) (:start . 90)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "decline") (:form . "decline") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 119)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 129)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 145)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 150) (:start . 146)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 169)\n  (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 174) (:start . 173)\n  (:id . 66))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 198)\n  (:start . 191) (:id . 70))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 206)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 219)\n  (:start . 214) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s960.2) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008986@unknown@formal@none@1@S@As a step toward elucidating the pathophysiological background of the so-called glucose toxicity to pancreatic beta cells, we induced glycation in HIT-T15 cells using a sugar with strong deoxidizing activity, D-ribose, and examined the effects on insulin gene transcription.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 9) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "VBG") (:stem . "elucidate") (:form . "elucidating") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pathophysiological") (:form . "pathophysiological")\n  (:end . 51) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "glycation") (:form . "glycation") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hit-t15") (:form . "HIT-T15") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 166) (:start . 161)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sugar") (:form . "sugar") (:end . 174)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 186)\n  (:start . 180) (:id . 70))\n ((:tag . "NN") (:stem . "deoxidizing") (:form . "deoxidizing") (:end . 198)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 207)\n  (:start . 199) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "D-ribose") (:form . "D-ribose") (:end . 217)\n  (:start . 209) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 76))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 231)\n  (:start . 223) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 243)\n  (:start . 236) (:id . 79))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 246) (:start . 244)\n  (:id . 80))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 254)\n  (:start . 247) (:id . 81))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 259) (:start . 255)\n  (:id . 82))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 273) (:start . 260) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s960.3) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008987@unknown@formal@none@1@S@The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM D-ribose, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . 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5008988@unknown@formal@none@1@S@In agreement with this, decrease in the insulin mRNA and insulin content was observed in the glycation-induced cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "glycation-induced") (:form . "glycation-induced")\n  (:end . 110) (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s960.5) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008990@unknown@formal@none@1@S@These effects of D-ribose seemed almost irreversible but could be prevented by addition of 1 mM aminoguanidine or 10 mM N-acetylcysteine, thus suggesting that glycation and reactive oxygen species, generated through the glycation reaction, serve as mediators of the phenomena.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-ribose") (:form . "D-ribose") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "seem") (:form . "seemed") (:end . 32) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mm") (:form . "mM") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "aminoguanidine") (:form . "aminoguanidine")\n  (:end . 110) (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 136) (:start . 120) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "glycation") (:form . "glycation") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 181)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 188)\n  (:start . 182) (:id . 70))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 196)\n  (:start . 189) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 207)\n  (:start . 198) (:id . 73))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 215)\n  (:start . 208) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "glycation") (:form . "glycation") (:end . 229)\n  (:start . 220) (:id . 76))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 238)\n  (:start . 230) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 78))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 245)\n  (:start . 240) (:id . 79))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 248) (:start . 246)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 258)\n  (:start . 249) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 261) (:start . 259)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 265) (:start . 262)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "phenomenon") (:form . "phenomena") (:end . 275)\n  (:start . 266) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x960.7.1) (:span 143 153))\n  ((:id . :x960.7.2) (:span 26 32)))\n (:hscopes ((:id . :x960.7.1) (:span 143 275))\n  ((:id . :x960.7.2) (:span 0 52)))\n (:identifiers (:sid . :s960.7) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008991@unknown@formal@none@1@S@These observations suggest that protein glycation in pancreatic beta cells, which occurs in vivo under chronic hyperglycemia, suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "glycation") (:form . "glycation") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "hyperglycemia") (:form . "hyperglycemia")\n  (:end . 124) (:start . 111) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 163) (:start . 150) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 189) (:start . 185)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 214)\n  (:start . 207) (:id . 74))\n ((:tag . "NN") (:stem . "toxicity") (:form . "toxicity") (:end . 223)\n  (:start . 215) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x960.8.1) (:span 19 26)))\n (:hscopes ((:id . :x960.8.1) (:span 19 223)))\n (:identifiers (:sid . :s960.8) (:did . :|9011569|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008992@unknown@formal@none@1@S@Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s961.1) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5008993@unknown@formal@none@1@S@The immunomodulatory cytokine IL-4 affects cells of most hemopoietic lineages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s961.2) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008994@unknown@formal@none@1@S@IL-4 is secreted by activated Th2 but not Th1 cells and plays a major role in the immune response by modulating the differentiation of naive Th cells toward the Th2 phenotype.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 88)\n  (:start . 82) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 97)\n  (:start . 89) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 111)\n  (:start . 101) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 131) (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "th") (:form . "Th") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 174)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x961.3.1) (:span 38 41)))\n (:nscopes ((:id . :x961.3.1) (:span 38 51)))\n (:identifiers (:sid . :s961.3) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008995@unknown@formal@none@1@S@We have previously identified an enhancer element, PRE-I, that is essential for the function of the human IL-4 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s961.4) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008996@unknown@formal@none@1@S@To investigate the mechanisms responsible for tissue-specific expression of the IL-4 gene, we analyzed nuclear factors binding to the PRE-I site and compared the binding activities of these factors to the IL-4 promoter of Th1 and Th2 cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 61) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 157)\n  (:start . 149) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 180)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 189)\n  (:start . 184) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 197)\n  (:start . 190) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 218)\n  (:start . 210) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 76))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 225) (:start . 222)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 229) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 233) (:start . 230)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 239)\n  (:start . 234) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s961.5) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008997@unknown@formal@none@1@S@We show that PRE-I interacts with PMA- and PMA/ionomycin-inducible, cyclosporin A-sensitive nuclear factors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PMA-") (:form . "PMA-") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pma/ionomycin-inducible")\n  (:form . "PMA/ionomycin-inducible") (:end . 66) (:start . 43) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "JJ") (:stem . "a-sensitive") (:form . "A-sensitive") (:end . 91)\n  (:start . 80) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s961.6) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5008998@unknown@formal@none@1@S@Using anti-C/EBPbeta (NF-IL6), anti-C/EBPdelta (NF-IL6beta), anti-NF-ATc, anti-NF-ATp, anti-Fos, and anti-Jun Abs we demonstrate that the previously identified PRE-I binding factor POS-1 is composed of different transcription factors in different Th cell subsets.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "anti-c/ebpbeta") (:form . "anti-C/EBPbeta")\n  (:end . 20) (:start . 6) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-c/ebpdelta") (:form . "anti-C/EBPdelta")\n  (:end . 46) (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-IL6beta") (:form . "NF-IL6beta") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-nf-atc") (:form . "anti-NF-ATc") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anti-nf-atp") (:form . "anti-NF-ATp") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-fos") (:form . "anti-Fos") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-jun") (:form . "anti-Jun") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 128)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 148)\n  (:start . 138) (:id . 66))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 159)\n  (:start . 149) (:id . 67))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 180)\n  (:start . 174) (:id . 70))\n ((:tag . "NN") (:stem . "pos-1") (:form . "POS-1") (:end . 186)\n  (:start . 181) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 198)\n  (:start . 190) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 211)\n  (:start . 202) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 225) (:start . 212) (:id . 76))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 233)\n  (:start . 226) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 246)\n  (:start . 237) (:id . 79))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 249) (:start . 247)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 254) (:start . 250)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 262)\n  (:start . 255) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s961.7) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009000@unknown@formal@none@1@S@In the mouse Th2 D10 cells and in the human Th2 clones, POS-1 (designated POS-1b) contains NF-IL6beta, Jun, and NF-ATc/p.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "d10") (:form . "D10") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 47) (:start . 44)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 54)\n  (:start . 48) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "POS-1") (:form . "POS-1") (:end . 61) (:start . 56)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 73)\n  (:start . 63) (:id . 57))\n ((:tag . "NNP") (:stem . "POS-1b") (:form . "POS-1b") (:end . 80)\n  (:start . 74) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 90)\n  (:start . 82) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-IL6beta") (:form . "NF-IL6beta") (:end . 101)\n  (:start . 91) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-ATc/p") (:form . "NF-ATc/p") (:end . 120)\n  (:start . 112) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s961.9) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009001@unknown@formal@none@1@S@In contrast, POS-1 was not found in nuclear extracts of human Th1 clones.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "POS-1") (:form . "POS-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x961.10.1) (:span 23 26)))\n (:nscopes ((:id . :x961.10.1) (:span 13 72)))\n (:identifiers (:sid . :s961.10) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009002@unknown@formal@none@1@S@These findings suggest that PRE-I may play a role in the differential regulation of IL-4 gene expression levels.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PRE-I") (:form . "PRE-I") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x961.11.1) (:span 34 37))\n  ((:id . :x961.11.2) (:span 15 22)))\n (:hscopes ((:id . :x961.11.1) (:span 34 111))\n  ((:id . :x961.11.2) (:span 15 111)))\n (:identifiers (:sid . :s961.11) (:did . :|9013959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009003@unknown@formal@none@1@S@Inhibitory effect of growth hormone on TNF-alpha secretion and nuclear factor-kappaB translocation in lipopolysaccharide-stimulated human monocytes.@(((:tag . "JJ") (:stem . "inhibitory") (:form . "Inhibitory") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 84) (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 98) (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 131) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 137)\n  (:start . 132) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 147)\n  (:start . 138) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s962.1) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009004@unknown@formal@none@1@S@Several studies have pointed to a link between immune and endocrine systems, including a regulatory function of GH on monocyte activation.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "point") (:form . "pointed") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "endocrine") (:form . "endocrine") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s962.2) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009005@unknown@formal@none@1@S@The present study demonstrates that human THP-1 promonocytic cells, engineered by gene transfer to constitutively produce human growth hormone (hGH), secreted depressed amounts of TNF-alpha in response to challenge by LPS.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "engineer") (:form . "engineered") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 113) (:start . 99) (:id . 57))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 134)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 142)\n  (:start . 135) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "hGH") (:form . "hGH") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 158)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "depressed") (:form . "depressed") (:end . 168)\n  (:start . 159) (:id . 67))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 189)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 71))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 201)\n  (:start . 193) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "VB") (:stem . "challenge") (:form . "challenge") (:end . 214)\n  (:start . 205) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s962.3) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009006@unknown@formal@none@1@S@The effect of GH appears to occur in an autocrine fashion, since the inhibitory effect on TNF-alpha secretion by constitutive GH production could be abolished in the presence of anti-hGH mAb.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 49)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 79)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 125)\n  (:start . 113) (:id . 62))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 174)\n  (:start . 166) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "anti-hgh") (:form . "anti-hGH") (:end . 186)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x962.4.1) (:span 140 145))\n  ((:id . :x962.4.2) (:span 17 24)))\n (:hscopes ((:id . :x962.4.1) (:span 65 190))\n  ((:id . :x962.4.2) (:span 0 57)))\n (:identifiers (:sid . :s962.4) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009007@unknown@formal@none@1@S@The GH-induced inhibitory effect was also observed using normal human monocytes and monocyte-derived macrophages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "gh-induced") (:form . "GH-induced") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 100) (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 112)\n  (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s962.5) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009008@unknown@formal@none@1@S@Inhibition of TNF-alpha production by THP-1-hGH-transfected cells cultured in the presence of LPS is dependent on a selective pathway, since no inhibition of TNF-alpha production was observed when cells were cultured in the presence of PMA.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "thp-1-hgh-transfected")\n  (:form . "THP-1-hGH-transfected") (:end . 59) (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 154)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 178)\n  (:start . 168) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 196) (:start . 192)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 216)\n  (:start . 208) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 75))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 232)\n  (:start . 224) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 239) (:start . 236)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x962.6.1) (:span 141 143)))\n (:nscopes ((:id . :x962.6.1) (:span 141 239)))\n (:identifiers (:sid . :s962.6) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009010@unknown@formal@none@1@S@The capacity of GH to inhibit LPS-induced TNF-alpha production by monocytes without altering other pathways leading to TNF-alpha production may be of potential relevance in septic shock, since GH is available for clinical use.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "VBG") (:stem . "alter") (:form . "altering") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "septic") (:form . "septic") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 185)\n  (:start . 180) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 69))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 192)\n  (:start . 187) (:id . 70))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 208)\n  (:start . 199) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 221)\n  (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 225) (:start . 222)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x962.8.1) (:span 150 159))\n  ((:id . :x962.8.2) (:span 140 143)))\n (:ncues ((:id . :x962.8.3) (:span 76 83)))\n (:hscopes ((:id . :x962.8.1) (:span 150 185))\n  ((:id . :x962.8.2) (:span 140 185)))\n (:nscopes ((:id . :x962.8.3) (:span 76 139)))\n (:identifiers (:sid . :s962.8) (:did . :|9013974|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009011@unknown@formal@none@1@S@Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging.@(((:tag . "JJ") (:stem . "impaired") (:form . "Impaired") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-fos/c-jun") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 99)\n  (:start . 91) (:id . 53))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-fos/c-jun") (:end . 111)\n  (:start . 100) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 120)\n  (:start . 112) (:id . 55))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 129)\n  (:start . 121) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 142)\n  (:start . 133) (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 148)\n  (:start . 143) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 150) (:start . 149)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 61))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 163)\n  (:start . 157) (:id . 62))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 169)\n  (:start . 164) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s963.1) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009012@unknown@formal@none@1@S@The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-Fos/c-Jun") (:end . 52)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 103) (:start . 89) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s963.2) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009013@unknown@formal@none@1@S@In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 37)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "aberrancy") (:form . "aberrancies") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-fos/c-jun") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "age-associated") (:form . "age-associated")\n  (:end . 153) (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "impairment") (:form . "impairments") (:end . 165)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 190)\n  (:start . 185) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x963.3.1) (:span 120 125))\n  ((:id . :x963.3.2) (:span 103 105)) ((:id . :x963.3.3) (:span 38 45)))\n (:hscopes ((:id . :x963.3.1) (:span 120 190))\n  ((:id . :x963.3.2) (:span 98 113)) ((:id . :x963.3.3) (:span 38 190)))\n (:identifiers (:sid . :s963.3) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009014@unknown@formal@none@1@S@Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . 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5009015@unknown@formal@none@1@S@In addition, RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RNase") (:form . "RNase") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protection") (:form . "protection") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-cd3/pma-stimulated")\n  (:form . "anti-CD3/PMA-stimulated") (:end . 74) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 142)\n  (:start . 133) (:id . 60))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 152)\n  (:start . 143) (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 159)\n  (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 168)\n  (:start . 163) (:id . 64))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 175)\n  (:start . 169) (:id . 65))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 181)\n  (:start . 176) (:id . 66))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 186) (:start . 182)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 195)\n  (:start . 187) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 200) (:start . 199)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 206)\n  (:start . 201) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 211) (:start . 207)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 217)\n  (:start . 212) (:id . 73))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 226)\n  (:start . 218) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s963.5) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009016@unknown@formal@none@1@S@Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "VBG") (:stem . "recognize") (:form . "recognizing") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "tre") (:form . "TRE") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "JJ") (:stem . "tre-like") (:form . "TRE-like") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 69))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 194)\n  (:start . 189) (:id . 71))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 203)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 211)\n  (:start . 204) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 213) (:start . 212)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 216) (:start . 213)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 217) (:start . 216)\n  (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 222) (:start . 218)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 233)\n  (:start . 223) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 244)\n  (:start . 237) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 248) (:start . 245)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 259)\n  (:start . 249) (:id . 82))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 261) (:start . 260)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 267)\n  (:start . 262) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s963.6) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009017@unknown@formal@none@1@S@Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . 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5009018@unknown@formal@none@1@S@Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SRE") (:form . "SRE") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "young") (:form . "young") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "elk-1") (:form . "Elk-1") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "pointing") (:form . "pointing") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 181)\n  (:start . 175) (:id . 69))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 193)\n  (:start . 182) (:id . 70))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 201)\n  (:start . 194) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 219)\n  (:start . 209) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 238) (:start . 223) (:id . 76))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 249)\n  (:start . 239) (:id . 77))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 258)\n  (:start . 250) (:id . 78))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 267)\n  (:start . 259) (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 272) (:start . 268)\n  (:id . 80))\n ((:tag . "NN") (:stem . "c-jun/ap-1") (:form . "c-jun/AP-1") (:end . 283)\n  (:start . 273) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 284) (:start . 283)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s963.8) (:did . :|9015187|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009020@unknown@formal@none@1@S@Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter.@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "rfx1") (:form . "RFX1") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mibp1") (:form . "MIBP1") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "hepatitis") (:form . "hepatitis") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s964.1) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009021@unknown@formal@none@1@S@The negative regulatory element (NRE) of the hepatitis B virus (HBV) core promoter contains three subregions which act synergistically to suppress core promoter activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "hepatitis") (:form . "hepatitis") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HBV") (:form . "HBV") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 73) (:start . 69)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 82)\n  (:start . 74) (:id . 58))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "subregion") (:form . "subregions") (:end . 108)\n  (:start . 98) (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 134) (:start . 119) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s964.2) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009022@unknown@formal@none@1@S@One of these subregions, NRE gamma, is active in both HeLa cervical carcinoma cells and Huh7 hepatoma cells and was found to be bound by a protein factor present in both cell types.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "subregion") (:form . "subregions") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 45)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cervical") (:form . "cervical") (:end . 67)\n  (:start . 59) (:id . 55))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 77)\n  (:start . 68) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "huh7") (:form . "Huh7") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hepatoma") (:form . "hepatoma") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 133)\n  (:start . 128) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 146)\n  (:start . 139) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 153)\n  (:start . 147) (:id . 71))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 161)\n  (:start . 154) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 169) (:start . 165)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 174) (:start . 170)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 180)\n  (:start . 175) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s964.3) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009023@unknown@formal@none@1@S@Here we show that the transcription factor RFX1 can bind to NRE gamma and transactivate the core promoter through this site.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "rfx1") (:form . "RFX1") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nre") (:form . "NRE") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 87) (:start . 74) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s964.4) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009024@unknown@formal@none@1@S@Mutations which abrogated the gene-suppressive activity of NRE gamma prevented RFX1 from binding to NRE gamma.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "gene-suppressive") (:form . "gene-suppressive")\n  (:end . 46) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "rfx1") (:form . "RFX1") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nre") (:form . "NRE") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s964.5) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009025@unknown@formal@none@1@S@In addition, RFX1 can bind simultaneously, most likely as a heterodimer, with the transcription factor MIBP1 to NRE gamma.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RFX1") (:form . "RFX1") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 41) (:start . 27) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 71)\n  (:start . 60) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "mibp1") (:form . "MIBP1") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nre") (:form . "NRE") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x964.6.1) (:span 48 54)))\n (:hscopes ((:id . :x964.6.1) (:span 48 71)))\n (:identifiers (:sid . :s964.6) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009026@unknown@formal@none@1@S@In the absence of a cloned MIBP1 gene for further studies, we hypothesize that RFX1 acts with MIBP1 to negatively regulate the core promoter activity through the NRE gamma site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "mibp1") (:form . "MIBP1") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "hypothesize") (:form . "hypothesize") (:end . 73)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rfx1") (:form . "RFX1") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mibp1") (:form . "MIBP1") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 113)\n  (:start . 103) (:id . 62))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 140)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 157)\n  (:start . 150) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NRE") (:form . "NRE") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 171)\n  (:start . 166) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x964.7.1) (:span 62 73)))\n (:ncues ((:id . :x964.7.2) (:span 7 14)))\n (:hscopes ((:id . :x964.7.1) (:span 62 176)))\n (:nscopes ((:id . :x964.7.2) (:span 7 57)))\n (:identifiers (:sid . :s964.7) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009027@unknown@formal@none@1@S@The ability of RFX1 to transactivate the core promoter raises the possibility that RFX1 may play a dual role in regulating HBV gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rfx1") (:form . "RFX1") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RFX1") (:form . "RFX1") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . "NNP") (:stem . "HBV") (:form . "HBV") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x964.8.1) (:span 88 91)) ((:id . :x964.8.2) (:span 55 77)))\n (:hscopes ((:id . :x964.8.1) (:span 88 142))\n  ((:id . :x964.8.2) (:span 55 142)))\n (:identifiers (:sid . :s964.8) (:did . :|9018153|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009028@unknown@formal@none@1@S@Differentiation-dependent expression of a human carboxylesterase in monocytic cells and transcription factor binding to the promoter.@(((:tag . "JJ") (:stem . "differentiation-dependent")\n  (:form . "Differentiation-dependent") (:end . 25) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 46))\n ((:tag . "NN") (:stem . "carboxylesterase") (:form . "carboxylesterase")\n  (:end . 64) (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 77)\n  (:start . 68) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 108)\n  (:start . 102) (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 132)\n  (:start . 124) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s965.1) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009030@unknown@formal@none@1@S@During the differentiation process of cells from the monocytic cell line THP-1 we observed a transient transcriptional upregulation of a human carboxylesterase analyzed by means of Northern blots.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 118) (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 131)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "carboxylesterase") (:form . "carboxylesterase")\n  (:end . 159) (:start . 143) (:id . 63))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 168)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "mean") (:form . "means") (:end . 177)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 189)\n  (:start . 181) (:id . 68))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 195)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s965.3) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009031@unknown@formal@none@1@S@In PMA-treated THP-1 cells we could detect three major transcription initiation sites as revealed by Nuclease Protection Assay carried out with two overlapping antisense RNA probes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pma-treated") (:form . "PMA-treated") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Nuclease") (:form . "Nuclease") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NNP") (:stem . "Protection") (:form . "Protection") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "NNP") (:stem . "Assay") (:form . "Assay") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "VBD") (:stem . "carry") (:form . "carried") (:end . 134)\n  (:start . 127) (:id . 60))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 159)\n  (:start . 148) (:id . 64))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 180)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s965.4) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009032@unknown@formal@none@1@S@We have recently cloned the carboxylesterase upstream sequence and showed its basal promoter activity in CHO cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "carboxylesterase") (:form . "carboxylesterase")\n  (:end . 44) (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 73) (:start . 67)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CHO") (:form . "CHO") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s965.5) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009033@unknown@formal@none@1@S@Using electrophoretic mobility shift analysis we demonstrated that the promoter region spanning base pairs -1 to -275, which contains several putative binding sites for transcription factors, is bound by nuclear factors Sp1 and IRBP but not by C/EBPs.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 61)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 86)\n  (:start . 80) (:id . 52))\n ((:tag . "VBG") (:stem . "span") (:form . "spanning") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "CD") (:stem . "-1") (:form . "-1") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-275") (:form . "-275") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 182) (:start . 169) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 190)\n  (:start . 183) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 200)\n  (:start . 195) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 211)\n  (:start . 204) (:id . 73))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 219)\n  (:start . 212) (:id . 74))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 223) (:start . 220)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IRBP") (:form . "IRBP") (:end . 232) (:start . 228)\n  (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 236) (:start . 233)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 240) (:start . 237)\n  (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 243) (:start . 241)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBPs") (:end . 250)\n  (:start . 244) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x965.6.2) (:span 142 150)))\n (:ncues ((:id . :x965.6.1) (:span 237 240)))\n (:hscopes ((:id . :x965.6.2) (:span 142 190)))\n (:nscopes ((:id . :x965.6.1) (:span 237 250)))\n (:identifiers (:sid . :s965.6) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009034@unknown@formal@none@1@S@Taken together these data indicate that carboxylesterase gene transcription in THP-1 cells starts at multiple initiation sites and that Sp1 and IRBP may be critical factors for modulating the differentiation-dependent transcription of this human carboxylesterase gene.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "carboxylesterase") (:form . "carboxylesterase")\n  (:end . 56) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "start") (:form . "starts") (:end . 97)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IRBP") (:form . "IRBP") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 164)\n  (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 172)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "differentiation-dependent")\n  (:form . "differentiation-dependent") (:end . 217) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 231) (:start . 218) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 239) (:start . 235)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 245)\n  (:start . 240) (:id . 75))\n ((:tag . "NN") (:stem . "carboxylesterase") (:form . "carboxylesterase")\n  (:end . 262) (:start . 246) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 267) (:start . 263)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x965.7.1) (:span 149 152))\n  ((:id . :x965.7.2) (:span 26 39)))\n (:hscopes ((:id . :x965.7.1) (:span 149 267))\n  ((:id . :x965.7.2) (:span 26 267)))\n (:identifiers (:sid . :s965.7) (:did . :|9020049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009035@unknown@formal@none@1@S@Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: identification of a GATA-2 binding element required for optimal transcriptional activity.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "platelet/endothelial")\n  (:form . "platelet/endothelial") (:end . 50) (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 85) (:start . 84)\n  (:id . 51))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 100) (:start . 86) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 112)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 120)\n  (:start . 113) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 128)\n  (:start . 121) (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 137)\n  (:start . 129) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 149)\n  (:start . 142) (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 165) (:start . 150) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 174)\n  (:start . 166) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s966.1) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009036@unknown@formal@none@1@S@Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the Ig gene superfamily that is expressed on platelets, endothelial cells, and certain leukocyte subsets.@(((:tag . "JJ") (:stem . "platelet/endothelial")\n  (:form . "Platelet/endothelial") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 34)\n  (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 45)\n  (:start . 35) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "130-kd") (:form . "130-kD") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 145)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 174)\n  (:start . 165) (:id . 69))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 182)\n  (:start . 175) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s966.2) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009037@unknown@formal@none@1@S@To examine the factors controlling vascular-specific expression of PECAM-1, we cloned the 5'-flanking region of the PECAM-1 gene and analyzed its transcriptional activity.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "vascular-specific") (:form . "vascular-specific")\n  (:end . 52) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "clone") (:form . "cloned") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "5'-flanking") (:form . "5'-flanking") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 161) (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 170)\n  (:start . 162) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s966.3) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009038@unknown@formal@none@1@S@5'-Rapid amplification of cDNA ends (5'-RACE) analysis showed that transcription initiation occurred at several closely spaced nearby sites originating approximately 204 bp upstream from the translation start site.@(((:tag . "JJ") (:stem . "5'-rapid") (:form . "5'-Rapid") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "amplification") (:form . "amplification")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "end") (:form . "ends") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "5'-RACE") (:form . "5'-RACE") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 61) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "JJ") (:stem . "spaced") (:form . "spaced") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . "JJ") (:stem . "nearby") (:form . "nearby") (:end . 133)\n  (:start . 127) (:id . 60))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "VBG") (:stem . "originate") (:form . "originating") (:end . 151)\n  (:start . 140) (:id . 62))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 165) (:start . 152) (:id . 63))\n ((:tag . "CD") (:stem . "204") (:form . "204") (:end . 169) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 181)\n  (:start . 173) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 186) (:start . 182)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 68))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 202)\n  (:start . 191) (:id . 69))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 208)\n  (:start . 203) (:id . 70))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 213) (:start . 209)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s966.4) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009040@unknown@formal@none@1@S@5'-serially truncated PECAM-1 promoter segments cloned in front of a luciferase reporter drove transcription in both a lineage- and orientation-specific manner.@(((:tag . "RB") (:stem . "5'-serially") (:form . "5'-serially") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 54)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "front") (:form . "front") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "VBD") (:stem . "drive") (:form . "drove") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lineage-") (:form . "lineage-") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "orientation-specific")\n  (:form . "orientation-specific") (:end . 152) (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 159)\n  (:start . 153) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s966.6) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009041@unknown@formal@none@1@S@Putative cis-acting control elements present within a 300-bp core promoter included two ets sites, an Sp1 site, tandem E-box domains, two GATA-associated sites (CACCC), an AP-2 binding site, and a GATA element at -24.@(((:tag . "JJ") (:stem . "putative") (:form . "Putative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "300-bp") (:form . "300-bp") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ets") (:form . "ets") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "e-box") (:form . "E-box") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "gata-associated") (:form . "GATA-associated")\n  (:end . 153) (:start . 138) (:id . 66))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CACCC") (:form . "CACCC") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 176) (:start . 172)\n  (:id . 73))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 184)\n  (:start . 177) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 201) (:start . 197)\n  (:id . 79))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 209)\n  (:start . 202) (:id . 80))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 212) (:start . 210)\n  (:id . 81))\n ((:tag . "CD") (:stem . "-24") (:form . "-24") (:end . 216) (:start . 213)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s966.7) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009042@unknown@formal@none@1@S@Mutational analysis showed that optimal transcriptional activity required the GATA sequence at position -24, and gel-shift assays further showed that the GATA-2 transcription factor, but not GATA-1, bound to this region of the PECAM-1 promoter.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 26) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 55) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 82) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . "CD") (:stem . "-24") (:form . "-24") (:end . 107) (:start . 104)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 137)\n  (:start . 130) (:id . 60))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 144)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gata-2") (:form . "GATA-2") (:end . 160)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 174) (:start . 161) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 181)\n  (:start . 175) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 197)\n  (:start . 191) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 204)\n  (:start . 199) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 212) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 219)\n  (:start . 213) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 77))\n ((:tag . "NN") (:stem . "pecam-1") (:form . "PECAM-1") (:end . 234)\n  (:start . 227) (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 243)\n  (:start . 235) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x966.8.1) (:span 187 190)))\n (:nscopes ((:id . :x966.8.1) (:span 187 197)))\n (:identifiers (:sid . :s966.8) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009043@unknown@formal@none@1@S@Understanding the cis- and transacting factors that regulate the tissue-specific expression of PECAM-1 should increase our understanding of the mechanisms by which vascular-specific gene expression is achieved.@(((:tag . "VBG") (:stem . "understand") (:form . "Understanding") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cis-") (:form . "cis-") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "transact") (:form . "transacting") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 80) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PECAM-1") (:form . "PECAM-1") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 109)\n  (:start . 103) (:id . 55))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 118)\n  (:start . 110) (:id . 56))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 122) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 136) (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 154)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 163)\n  (:start . 158) (:id . 63))\n ((:tag . "JJ") (:stem . "vascular-specific") (:form . "vascular-specific")\n  (:end . 181) (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 197)\n  (:start . 187) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 200) (:start . 198)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 209)\n  (:start . 201) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x966.9.1) (:span 103 109)))\n (:hscopes ((:id . :x966.9.1) (:span 103 209)))\n (:identifiers (:sid . :s966.9) (:did . :|9028949|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009044@unknown@formal@none@1@S@Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.@(((:tag . "NN") (:stem . "cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "myeloid-cell-specific")\n  (:form . "myeloid-cell-specific") (:end . 48) (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 62) (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 83)\n  (:start . 77) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s967.1) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009045@unknown@formal@none@1@S@Chicken NF-M transcription factor, in cooperation with either c-Myb or v-Myb, is active in the combinatorial activation of myeloid-cell-specific genes in heterologous cell types, such as embryonic fibroblasts.@(((:tag . "NNP") (:stem . "Chicken") (:form . "Chicken") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-M") (:form . "NF-M") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "v-myb") (:form . "v-Myb") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "combinatorial") (:form . "combinatorial")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "myeloid-cell-specific")\n  (:form . "myeloid-cell-specific") (:end . 144) (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 166)\n  (:start . 154) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 177)\n  (:start . 172) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 183) (:start . 179)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 196)\n  (:start . 187) (:id . 71))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 208)\n  (:start . 197) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s967.2) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009046@unknown@formal@none@1@S@In humans, similar effects were observed with homologous members of the CCAAT/enhancer-binding protein (C/EBP) family of transcriptional regulators, especially the human homolog of chicken NF-M, C/EBP-beta (NF-IL6).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ccaat/enhancer-binding")\n  (:form . "CCAAT/enhancer-binding") (:end . 94) (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 136) (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 169)\n  (:start . 164) (:id . 66))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 188)\n  (:start . 181) (:id . 69))\n ((:tag . "NNP") (:stem . "NF-M") (:form . "NF-M") (:end . 193) (:start . 189)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "C/EBP-beta") (:form . "C/EBP-beta") (:end . 205)\n  (:start . 195) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 207) (:start . 206)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 213)\n  (:start . 207) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 214) (:start . 213)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s967.3) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009047@unknown@formal@none@1@S@However, the NF-IL6 gene is expressed in a variety of nonmyeloid cell types and is strongly inducible in response to inflammatory stimuli, making it an unlikely candidate to have an exclusive role as a combinatorial differentiation switch during myelopoiesis in human cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nonmyeloid") (:form . "nonmyeloid") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 129)\n  (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 145)\n  (:start . 139) (:id . 66))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "unlikely") (:form . "unlikely") (:end . 160)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 178) (:start . 174)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 201) (:start . 200)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "combinatorial") (:form . "combinatorial")\n  (:end . 215) (:start . 202) (:id . 78))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 231) (:start . 216) (:id . 79))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 238)\n  (:start . 232) (:id . 80))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 245)\n  (:start . 239) (:id . 81))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 258)\n  (:start . 246) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 261) (:start . 259)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 267)\n  (:start . 262) (:id . 84))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 273)\n  (:start . 268) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x967.4.1) (:span 152 160)))\n (:hscopes ((:id . :x967.4.1) (:span 152 273)))\n (:identifiers (:sid . :s967.4) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009048@unknown@formal@none@1@S@By using a reverse transcription-PCR-based approach and a set of primers specific for the DNA-binding domains of highly homologous members of the C/EBP family of transcriptional regulators, we have cloned a novel human gene encoding a member of the C/EBP gene family, identified as the human homolog of CRP1, C/EBP-epsilon.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "transcription-pcr-based")\n  (:form . "transcription-PCR-based") (:end . 42) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 177) (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 188)\n  (:start . 178) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 197) (:start . 193)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 204)\n  (:start . 198) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 206) (:start . 205)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 212)\n  (:start . 207) (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 218)\n  (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 223) (:start . 219)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 232)\n  (:start . 224) (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 234) (:start . 233)\n  (:id . 78))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 241)\n  (:start . 235) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 244) (:start . 242)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 248) (:start . 245)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 254)\n  (:start . 249) (:id . 82))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 259) (:start . 255)\n  (:id . 83))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 266)\n  (:start . 260) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 267) (:start . 266)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 278)\n  (:start . 268) (:id . 86))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 281) (:start . 279)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 285) (:start . 282)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 291)\n  (:start . 286) (:id . 89))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 299)\n  (:start . 292) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 302) (:start . 300)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "CRP1") (:form . "CRP1") (:end . 307) (:start . 303)\n  (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 308) (:start . 307)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 322) (:start . 309) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 323) (:start . 322)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s967.5) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009050@unknown@formal@none@1@S@Molecular analysis of the cDNA and genomic clones indicated the presence of two exons encoding a protein with an apparent molecular mass of 32 kDa and a pI of 9.5.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "pi") (:form . "pI") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "CD") (:stem . "9.5") (:form . "9.5") (:end . 162) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x967.7.1) (:span 113 121)))\n (:hscopes ((:id . :x967.7.1) (:span 113 146)))\n (:identifiers (:sid . :s967.7) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009051@unknown@formal@none@1@S@Primer extension analysis of C/EBP-epsilon mRNA detected a single major transcription start site approximately 200 bp upstream of the start codon.@(((:tag . "NNP") (:stem . "Primer") (:form . "Primer") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 110) (:start . 97) (:id . 55))\n ((:tag . "CD") (:stem . "200") (:form . "200") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 145)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s967.8) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009052@unknown@formal@none@1@S@The putative promoter area is similar to those of several other myeloid-cell-specific genes in that it contains no TATAAA box but has a number of purine-rich stretches with multiple sites for the factors of the Ets family of transcriptional regulators.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "myeloid-cell-specific")\n  (:form . "myeloid-cell-specific") (:end . 85) (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TATAAA") (:form . "TATAAA") (:end . 121)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "purine-rich") (:form . "purine-rich") (:end . 157)\n  (:start . 146) (:id . 67))\n ((:tag . "NNS") (:stem . "stretch") (:form . "stretches") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 181)\n  (:start . 173) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 187)\n  (:start . 182) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 203)\n  (:start . 196) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 214) (:start . 211)\n  (:id . 77))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 221)\n  (:start . 215) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 240) (:start . 225) (:id . 80))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 251)\n  (:start . 241) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x967.9.1) (:span 112 114)))\n (:nscopes ((:id . :x967.9.1) (:span 112 125)))\n (:identifiers (:sid . :s967.9) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009053@unknown@formal@none@1@S@Northern blot analyses indicated a highly restricted mRNA expression pattern, with the strongest expression occurring in promyelocyte and late-myeloblast-like cell lines.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "strong") (:form . "strongest") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 133)\n  (:start . 121) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "late-myeloblast-like")\n  (:form . "late-myeloblast-like") (:end . 158) (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 163) (:start . 159)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 169)\n  (:start . 164) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s967.10) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009054@unknown@formal@none@1@S@Western blot and immunoprecipitation studies using rabbit anti-C/EBP-epsilon antibodies raised against the N-terminal portion of C/EBP-epsilon (amino acids 1 to 115) showed that C/EBP-epsilon is a 32-kDa nuclear phosphoprotein.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 36) (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "JJ") (:stem . "anti-c/ebp-epsilon") (:form . "anti-C/EBP-epsilon")\n  (:end . 76) (:start . 58) (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 87)\n  (:start . 77) (:id . 50))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 94)\n  (:start . 88) (:id . 51))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 102)\n  (:start . 95) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 117)\n  (:start . 107) (:id . 54))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 125)\n  (:start . 118) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 142) (:start . 129) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 58))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 149)\n  (:start . 144) (:id . 59))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 155)\n  (:start . 150) (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 157) (:start . 156)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 62))\n ((:tag . "CD") (:stem . "115") (:form . "115") (:end . 164) (:start . 161)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 172)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 191) (:start . 178) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 194) (:start . 192)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 196) (:start . 195)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "32-kda") (:form . "32-kDa") (:end . 203)\n  (:start . 197) (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 211)\n  (:start . 204) (:id . 71))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 226) (:start . 212) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s967.11) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009055@unknown@formal@none@1@S@The human C/EBP-epsilon protein exhibited strong and specific binding to double-stranded DNA containing consensus C/EBP sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 88) (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 119)\n  (:start . 114) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 125)\n  (:start . 120) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s967.12) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009056@unknown@formal@none@1@S@Cotransfection of the C/EBP-epsilon sense and antisense expression constructs together with chloramphenicol acetyltransferase reporter vectors containing myeloid-cell-specific c-mim and human myeloperoxidase promoters suggested a role for C/EBP-epsilon transcription factor in the regulation of a subset of myeloid-cell-specific genes.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 107) (:start . 92) (:id . 53))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 125) (:start . 108) (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 134)\n  (:start . 126) (:id . 55))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 142)\n  (:start . 135) (:id . 56))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 153)\n  (:start . 143) (:id . 57))\n ((:tag . "JJ") (:stem . "myeloid-cell-specific")\n  (:form . "myeloid-cell-specific") (:end . 175) (:start . 154) (:id . 58))\n ((:tag . "NN") (:stem . "c-mim") (:form . "c-mim") (:end . 181)\n  (:start . 176) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 191)\n  (:start . 186) (:id . 61))\n ((:tag . "NN") (:stem . "myeloperoxidase") (:form . "myeloperoxidase")\n  (:end . 207) (:start . 192) (:id . 62))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 217)\n  (:start . 208) (:id . 63))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 227)\n  (:start . 218) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 229) (:start . 228)\n  (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 234) (:start . 230)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 238) (:start . 235)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 252) (:start . 239) (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 266) (:start . 253) (:id . 69))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 273)\n  (:start . 267) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 276) (:start . 274)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 280) (:start . 277)\n  (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 291)\n  (:start . 281) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 294) (:start . 292)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 296) (:start . 295)\n  (:id . 75))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 303)\n  (:start . 297) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 306) (:start . 304)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "myeloid-cell-specific")\n  (:form . "myeloid-cell-specific") (:end . 328) (:start . 307) (:id . 78))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 334)\n  (:start . 329) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 335) (:start . 334)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x967.13.1) (:span 218 227)))\n (:hscopes ((:id . :x967.13.1) (:span 218 334)))\n (:identifiers (:sid . :s967.13) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009057@unknown@formal@none@1@S@Transient tranfection of a promyelocyte cell line (NB4) with a C/EBP-epsilon expression plasmid increased cell growth by sevenfold, while antisense C/EBP-epsilon caused a fivefold decrease in clonal growth of these cells.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tranfection") (:form . "tranfection") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "promyelocyte") (:form . "promyelocyte") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 76) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "RB") (:stem . "sevenfold") (:form . "sevenfold") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "NNP") (:stem . "C/EBP-epsilon") (:form . "C/EBP-epsilon")\n  (:end . 161) (:start . 148) (:id . 65))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 168)\n  (:start . 162) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "fivefold") (:form . "fivefold") (:end . 179)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 188)\n  (:start . 180) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 198)\n  (:start . 192) (:id . 71))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 205)\n  (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 214)\n  (:start . 209) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s967.14) (:did . :|9032264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009058@unknown@formal@none@1@S@Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ferritin") (:form . "ferritin") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "heavy-chain") (:form . "heavy-chain") (:end . 54)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CCAAT") (:form . "CCAAT") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "nf-y") (:form . "NF-Y") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "heme-treated") (:form . "heme-treated") (:end . 135)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "Friend") (:form . "Friend") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 168)\n  (:start . 162) (:id . 66))\n ((:tag . "JJ") (:stem . "monocyte-to-macrophage")\n  (:form . "monocyte-to-macrophage") (:end . 191) (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 207) (:start . 192) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s968.1) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009060@unknown@formal@none@1@S@In the majority of cell lines studied, the regulation of ferritin expression was exerted mostly at the translational level.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ferritin") (:form . "ferritin") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "exert") (:form . "exerted") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s968.3) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009061@unknown@formal@none@1@S@However, in differentiating erythroid cells, which must incorporate high levels of iron to sustain hemoglobin synthesis, and in macrophages, which are involved in iron storage, transcriptional regulation seemed to be a relevant mechanism.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VB") (:stem . "incorporate") (:form . "incorporate") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "sustain") (:form . "sustain") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 139)\n  (:start . 128) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "storage") (:form . "storage") (:end . 175)\n  (:start . 168) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 192) (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 203)\n  (:start . 193) (:id . 73))\n ((:tag . "VBD") (:stem . "seem") (:form . "seemed") (:end . 210)\n  (:start . 204) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 213) (:start . 211)\n  (:id . 75))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 216) (:start . 214)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 218) (:start . 217)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 227)\n  (:start . 219) (:id . 78))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 237)\n  (:start . 228) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x968.4.1) (:span 204 210)))\n (:hscopes ((:id . :x968.4.1) (:span 177 237)))\n (:identifiers (:sid . :s968.4) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009062@unknown@formal@none@1@S@We show here that the minimum region of the ferritin H-gene promoter that is able to confer transcriptional regulation by heme in FLCs to a reporter gene is 77 nucleotides upstream of the TATA box.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ferritin") (:form . "ferritin") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NNP") (:stem . "H-gene") (:form . "H-gene") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 107) (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "heme") (:form . "heme") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "flc") (:form . "FLCs") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "CD") (:stem . "77") (:form . "77") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 171)\n  (:start . 160) (:id . 71))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 180)\n  (:start . 172) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 196) (:start . 193)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s968.5) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009063@unknown@formal@none@1@S@This cis element binds a protein complex referred to as HRF (heme-responsive factor), which is greatly enhanced both in heme-treated FLCs and during monocyte-to-macrophage differentiation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HRF") (:form . "HRF") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "heme-responsive") (:form . "heme-responsive")\n  (:end . 76) (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "heme-treated") (:form . "heme-treated") (:end . 132)\n  (:start . 120) (:id . 64))\n ((:tag . "NNS") (:stem . "flc") (:form . "FLCs") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 148)\n  (:start . 142) (:id . 67))\n ((:tag . "JJ") (:stem . "monocyte-to-macrophage")\n  (:form . "monocyte-to-macrophage") (:end . 171) (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 187) (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s968.6) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009064@unknown@formal@none@1@S@The CCAAT element present in reverse orientation in this promoter region of the ferritin H-chain gene is necessary for binding and for gene activity, since a single point mutation is able to abolish the binding of HRF and the transcriptional activity in transfected cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CCAAT") (:form . "CCAAT") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ferritin") (:form . "ferritin") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "h-chain") (:form . "H-chain") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 74))\n ((:tag . "VB") (:stem . "abolish") (:form . "abolish") (:end . 198)\n  (:start . 191) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 210)\n  (:start . 203) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "HRF") (:form . "HRF") (:end . 217) (:start . 214)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 241) (:start . 226) (:id . 82))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 250)\n  (:start . 242) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 253) (:start . 251)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 265)\n  (:start . 254) (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 271)\n  (:start . 266) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s968.7) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009065@unknown@formal@none@1@S@By competition experiments and supershift assays, we identified the induced HRF as containing at least the ubiquitous transcription factor NF-Y.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "hrf") (:form . "HRF") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 117)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "nf-y") (:form . "NF-Y") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s968.8) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009066@unknown@formal@none@1@S@NF-Y is formed by three subunits, A, B, and C, all of which are necessary for DNA binding.@(((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 45) (:start . 44)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 50) (:start . 47)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 73)\n  (:start . 64) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s968.9) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009067@unknown@formal@none@1@S@Cotransfection with a transdominant negative mutant of the NF-YA subunit abolishes the transcriptional activation by heme, indicating that NF-Y plays an essential role in this activation.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transdominant") (:form . "transdominant")\n  (:end . 35) (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-YA") (:form . "NF-YA") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 102) (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "heme") (:form . "heme") (:end . 121) (:start . 117)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 133)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-Y") (:form . "NF-Y") (:end . 143) (:start . 139)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 149)\n  (:start . 144) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 162)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 175) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 186)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x968.10.1) (:span 123 138)))\n (:hscopes ((:id . :x968.10.1) (:span 123 186)))\n (:identifiers (:sid . :s968.10) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009068@unknown@formal@none@1@S@We have also observed a differential expression of the NF-YA subunit in heme-treated and control FLCs and during monocyte-to-macrophage differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-YA") (:form . "NF-YA") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "heme-treated") (:form . "heme-treated") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "flc") (:form . "FLCs") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "monocyte-to-macrophage")\n  (:form . "monocyte-to-macrophage") (:end . 135) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 151) (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s968.11) (:did . :|9032265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009070@unknown@formal@none@1@S@Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).@(((:tag . "JJ") (:stem . "numerous") (:form . "Numerous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s969.2) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009071@unknown@formal@none@1@S@Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.@(((:tag . "VBN") (:stem . "associate") (:form . "Associated") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "VBZ") (:stem . "reside") (:form . "resides") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s969.3) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009072@unknown@formal@none@1@S@Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "proteolyze") (:form . "proteolyzed") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "VBZ") (:stem . "translocate") (:form . "translocates") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s969.4) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009073@unknown@formal@none@1@S@The transduction pathways that lead to I kappaB inactivation remain poorly understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s969.5) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009074@unknown@formal@none@1@S@In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 36) (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "70/z3-derived") (:form . "70/Z3-derived")\n  (:end . 73) (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 136)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 167)\n  (:start . 160) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x969.6.1) (:span 114 117)))\n (:nscopes ((:id . :x969.6.1) (:span 114 167)))\n (:identifiers (:sid . :s969.6) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009075@unknown@formal@none@1@S@We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 58) (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Taxol") (:form . "Taxol") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 127) (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 141)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 163)\n  (:start . 155) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 176)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 190)\n  (:start . 183) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 201)\n  (:start . 194) (:id . 76))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 217) (:start . 202) (:id . 77))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 220) (:start . 218)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "serine") (:form . "serines") (:end . 228)\n  (:start . 221) (:id . 79))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 231) (:start . 229)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 81))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 238) (:start . 236)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x969.7.1) (:span 183 190))\n  ((:id . :x969.7.2) (:span 151 154)))\n (:nscopes ((:id . :x969.7.1) (:span 183 238))\n  ((:id . :x969.7.2) (:span 133 163)))\n (:identifiers (:sid . :s969.7) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009076@unknown@formal@none@1@S@Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.@(((:tag . "CC") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "relA") (:form . "relA") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 75) (:start . 72)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 81) (:start . 76)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 90)\n  (:start . 82) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 103)\n  (:start . 94) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 111) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 116) (:start . 112)\n  (:id . 65))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 121) (:start . 117)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "account") (:form . "accounts") (:end . 131)\n  (:start . 123) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 156) (:start . 141) (:id . 71))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 163)\n  (:start . 157) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x969.8.1) (:span 0 7 37 40)))\n (:nscopes ((:id . :x969.8.1) (:span 0 163)))\n (:identifiers (:sid . :s969.8) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009077@unknown@formal@none@1@S@As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).@(((:tag . "RB") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "culminate") (:form . "culminating") (:end . 22)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "serine") (:form . "serines") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 129)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 152)\n  (:start . 145) (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 166)\n  (:start . 155) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 185)\n  (:start . 174) (:id . 74))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 197)\n  (:start . 186) (:id . 75))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 213) (:start . 198) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 219) (:start . 215)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s969.9) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009078@unknown@formal@none@1@S@In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hyperosmotic") (:form . "hyperosmotic") (:end . 41)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pdtc-insensitive") (:form . "PDTC-insensitive")\n  (:end . 101) (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 145)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s969.10) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009080@unknown@formal@none@1@S@We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HTLV-1)-derived") (:form . "HTLV-1)-derived")\n  (:end . 75) (:start . 60) (:id . 54))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 95) (:start . 80) (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "VB") (:stem . "operate") (:form . "operate") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 202)\n  (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 210)\n  (:start . 203) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x969.12.2) (:span 133 143)))\n (:ncues ((:id . :x969.12.1) (:span 173 176)))\n (:hscopes ((:id . :x969.12.2) (:span 133 210)))\n (:nscopes ((:id . :x969.12.1) (:span 173 210)))\n (:identifiers (:sid . :s969.12) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009081@unknown@formal@none@1@S@Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 40)\n  (:start . 34) (:id . 50))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 60)\n  (:start . 54) (:id . 54))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 65) (:start . 61)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 82)\n  (:start . 74) (:id . 58))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 93)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 102)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 128)\n  (:start . 120) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 68))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 141)\n  (:start . 136) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 146) (:start . 142)\n  (:id . 70))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 151) (:start . 147)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 161)\n  (:start . 152) (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 173)\n  (:start . 162) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x969.13.1) (:span 116 119)))\n (:nscopes ((:id . :x969.13.1) (:span 22 173)))\n (:identifiers (:sid . :s969.13) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009082@unknown@formal@none@1@S@Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "1.3e2") (:form . "1.3E2") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "VBG") (:stem . "exhibit") (:form . "exhibiting") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 166)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s969.14) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009083@unknown@formal@none@1@S@In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "trigger") (:form . "trigger") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 132)\n  (:start . 126) (:id . 67))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 140)\n  (:start . 133) (:id . 68))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 152)\n  (:start . 141) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x969.15.1) (:span 27 35)))\n (:hscopes ((:id . :x969.15.1) (:span 27 152)))\n (:identifiers (:sid . :s969.15) (:did . :|9032271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009084@unknown@formal@none@1@S@Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 105) (:start . 102)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x970.1.1) (:span 95 98)))\n (:nscopes ((:id . :x970.1.1) (:span 95 111)))\n (:identifiers (:sid . :s970.1) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009085@unknown@formal@none@1@S@Transcriptional factors of the NFAT family play an important role in regulating the expression of several cytokine genes during the immune response, such as the genes for interleukin 2 (IL-2) and IL-4, among others.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 166)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 182)\n  (:start . 171) (:id . 70))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 200) (:start . 196)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 77))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 207)\n  (:start . 202) (:id . 78))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 214)\n  (:start . 208) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s970.2) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009086@unknown@formal@none@1@S@Upon antigen stimulation, precursor CD4+ T helper (pTh) cells proliferate and differentiate into two populations of effector cells (eTh1 and eTh2), each one expressing a specific pattern of cytokines that distinguishes them from their precursors.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pth") (:form . "pTh") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "proliferate") (:form . "proliferate") (:end . 73)\n  (:start . 62) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 112)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "NN") (:stem . "one") (:form . "one") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 167)\n  (:start . 157) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 178)\n  (:start . 170) (:id . 73))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 186)\n  (:start . 179) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 199)\n  (:start . 190) (:id . 76))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 204) (:start . 200)\n  (:id . 77))\n ((:tag . "VBZ") (:stem . "distinguish") (:form . "distinguishes")\n  (:end . 218) (:start . 205) (:id . 78))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 223) (:start . 219)\n  (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 228) (:start . 224)\n  (:id . 80))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 234)\n  (:start . 229) (:id . 81))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 245)\n  (:start . 235) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s970.3) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009087@unknown@formal@none@1@S@eTh2 cells are the major source of IL-4, while gamma interferon is produced by eTh1 cells.@(((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interferon") (:form . "interferon") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s970.4) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009088@unknown@formal@none@1@S@Here we have used reporter transgenic mice to show that DNA binding and transcriptional activities of NFAT are transiently induced during the differentiation of pTh cells into either eTh1 or eTh2 cells to mediate the expression of IL-2 as a common growth factor in both pathways.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 87) (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 157) (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "pth") (:form . "pTh") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 190) (:start . 188)\n  (:id . 71))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 195) (:start . 191)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 201)\n  (:start . 196) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 212)\n  (:start . 205) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 227)\n  (:start . 217) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 235) (:start . 231)\n  (:id . 79))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 238) (:start . 236)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 240) (:start . 239)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 247)\n  (:start . 241) (:id . 82))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 254)\n  (:start . 248) (:id . 83))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 261)\n  (:start . 255) (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 85))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 269) (:start . 265)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 278)\n  (:start . 270) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s970.5) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009090@unknown@formal@none@1@S@In contrast to activated pTh cells, neither eTh1 nor eTh2 cells produced significant IL-2 upon stimulation, but the high levels of NFAT transcriptional activities directly correlate with the IL-4 production induced in response to antigen stimulation in eTh2 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "pth") (:form . "pTh") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 106)\n  (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 151) (:start . 136) (:id . 66))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 162)\n  (:start . 152) (:id . 67))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 195) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 206)\n  (:start . 196) (:id . 73))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 214)\n  (:start . 207) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 226)\n  (:start . 218) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 229) (:start . 227)\n  (:id . 77))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 237)\n  (:start . 230) (:id . 78))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 249)\n  (:start . 238) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 80))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 257) (:start . 253)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 263)\n  (:start . 258) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x970.7.1) (:span 36 43 49 52)))\n (:nscopes ((:id . :x970.7.1) (:span 36 106)))\n (:identifiers (:sid . :s970.7) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009091@unknown@formal@none@1@S@These data suggest that activated NFAT is involved in the effector function of eTh2 cells and that the failure of eTh1 cells to produce IL-4 in response to an antigen is due, at least partially, to a failure to induce high-level transcription of the IL-4 gene by NFAT.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . 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5009092@unknown@formal@none@1@S@Regulation of NFAT could be therefore a critical element in the polarization to eTh1 or eTh2.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "polarization") (:form . "polarization") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "eth1") (:form . "eTh1") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "eth2") (:form . "eTh2") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x970.9.1) (:span 19 24)))\n (:hscopes ((:id . :x970.9.1) (:span 19 92)))\n (:identifiers (:sid . :s970.9) (:did . :|9032280|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009093@unknown@formal@none@1@S@Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 128) (:start . 113) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "VBG") (:stem . "influence") (:form . "influencing") (:end . 162)\n  (:start . 151) (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 168)\n  (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 185) (:start . 169) (:id . 66))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 191)\n  (:start . 186) (:id . 67))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 203)\n  (:start . 192) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 216)\n  (:start . 207) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 227)\n  (:start . 221) (:id . 72))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 239)\n  (:start . 228) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x971.1.1) (:span 132 140)))\n (:hscopes ((:id . :x971.1.1) (:span 132 239)))\n (:identifiers (:sid . :s971.1) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009094@unknown@formal@none@1@S@Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "replicate") (:form . "replicates") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 98) (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s971.2) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009095@unknown@formal@none@1@S@We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 120) (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x971.3.1) (:span 29 32)) ((:id . :x971.3.2) (:span 16 23)))\n (:hscopes ((:id . :x971.3.1) (:span 29 120))\n  ((:id . :x971.3.2) (:span 16 120)))\n (:identifiers (:sid . :s971.3) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009096@unknown@formal@none@1@S@We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "VBD") (:stem . "change") (:form . "changed") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 106) (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 127) (:start . 112) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 136)\n  (:start . 131) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 156) (:start . 140) (:id . 60))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 168)\n  (:start . 157) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 62))\n ((:tag . "NNPS") (:stem . "MDM") (:form . "MDMs") (:end . 174) (:start . 170)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 195) (:start . 180) (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 203) (:start . 199)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 206) (:start . 204)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 215)\n  (:start . 207) (:id . 70))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 227)\n  (:start . 216) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "AM") (:form . "AMs") (:end . 232) (:start . 229)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s971.4) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009097@unknown@formal@none@1@S@Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers.@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 41) (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 51)\n  (:start . 42) (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 56) (:start . 52)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 84) (:start . 67) (:id . 50))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 93)\n  (:start . 85) (:id . 51))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 97) (:start . 94)\n  (:id . 52))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 107)\n  (:start . 98) (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 113)\n  (:start . 108) (:id . 54))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 123)\n  (:start . 114) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 56))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 133) (:start . 129)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 58))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 144)\n  (:start . 137) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "favor") (:form . "favor") (:end . 153)\n  (:start . 148) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 63))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 178) (:start . 161) (:id . 64))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 185)\n  (:start . 179) (:id . 65))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 193)\n  (:start . 186) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p50/relb") (:form . "p50/RelB") (:end . 206)\n  (:start . 198) (:id . 68))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 219)\n  (:start . 207) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s971.5) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009098@unknown@formal@none@1@S@As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MDM") (:form . "MDMs") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AM") (:form . "AMs") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 30) (:start . 16) (:id . 47))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50/relb") (:form . "p50/RelB") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s971.6) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009100@unknown@formal@none@1@S@The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 56) (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 76)\n  (:start . 64) (:id . 50))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 86)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 91) (:start . 87)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 116)\n  (:start . 107) (:id . 56))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 124)\n  (:start . 117) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "progressive") (:form . "progressive") (:end . 140)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 149)\n  (:start . 141) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 167) (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 180)\n  (:start . 171) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 187) (:start . 184)\n  (:id . 66))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 197)\n  (:start . 188) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 204)\n  (:start . 198) (:id . 68))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 69))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 213)\n  (:start . 208) (:id . 70))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 221)\n  (:start . 214) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x971.8.1) (:span 103 106)))\n (:hscopes ((:id . :x971.8.1) (:span 103 221)))\n (:identifiers (:sid . :s971.8) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009101@unknown@formal@none@1@S@The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 64) (:start . 49) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 119) (:start . 104) (:id . 57))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 130)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 139)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 156)\n  (:start . 145) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 172)\n  (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 184)\n  (:start . 173) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x971.9.1) (:span 73 76)))\n (:hscopes ((:id . :x971.9.1) (:span 73 184)))\n (:identifiers (:sid . :s971.9) (:did . :|9032344|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009102@unknown@formal@none@1@S@Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mcf13") (:form . "MCF13") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 86)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 101) (:start . 96)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 115)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 122)\n  (:start . 116) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 135)\n  (:start . 126) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 137) (:start . 136)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s972.1) (:did . :|9032403|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009103@unknown@formal@none@1@S@The region downstream of the enhancer (DEN) of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for viral pathogenicity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DEN") (:form . "DEN") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mink") (:form . "mink") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "focus-forming") (:form . "focus-forming")\n  (:end . 102) (:start . 89) (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "pathogenicity") (:form . "pathogenicity")\n  (:end . 161) (:start . 148) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s972.2) (:did . :|9032403|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009104@unknown@formal@none@1@S@Another important activity of DEN is its control of transcription in activated T cells, and we have determined that an NF-kappaB site is critical for this activity.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DEN") (:form . "DEN") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s972.3) (:did . :|9032403|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009105@unknown@formal@none@1@S@Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "t-lymphocytic") (:form . "T-lymphocytic")\n  (:end . 67) (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hypochlorous") (:form . "hypochlorous") (:end . 93)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s973.1) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009106@unknown@formal@none@1@S@Reactive oxygen species (ROS) such as hydrogen peroxide serve as second messengers in the induction of the transcription factor NF-kappaB, and hence in the activation and replication of human immunodeficiency virus type 1 (HIV-1) in human cells.@(((:tag . "JJ") (:stem . "reactive") (:form . "Reactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 166)\n  (:start . 156) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 182)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 191)\n  (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 208) (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 214)\n  (:start . 209) (:id . 75))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 219) (:start . 215)\n  (:id . 76))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 221) (:start . 220)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 223) (:start . 222)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 228)\n  (:start . 223) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 229) (:start . 228)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 238)\n  (:start . 233) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 244)\n  (:start . 239) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s973.2) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009107@unknown@formal@none@1@S@During inflammatory reactions, many oxidative species are produced, one of which is hypochlorous acid (HOCl), which is responsible for the microbicidal effects of activated human polymorphonuclear leukocytes.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hypochlorous") (:form . "hypochlorous") (:end . 96)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 130)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "microbicidal") (:form . "microbicidal") (:end . 151)\n  (:start . 139) (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 159)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 172)\n  (:start . 163) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 196) (:start . 179) (:id . 72))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 207)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s973.3) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009108@unknown@formal@none@1@S@Treatment of a T-lymphocytic cell line with micromolar concentrations of HOCl promoted the appearance of transcription factor NF-kappaB (the heterodimer p50/p65) in the nucleus of the cells, even in the absence of de novo protein synthesis.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "t-lymphocytic") (:form . "T-lymphocytic")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "micromolar") (:form . "micromolar") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 69) (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 125)\n  (:start . 119) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 135)\n  (:start . 126) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 160)\n  (:start . 153) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 195) (:start . 191)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 210)\n  (:start . 203) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 76))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 216) (:start . 214)\n  (:id . 77))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 221) (:start . 217)\n  (:id . 78))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 229)\n  (:start . 222) (:id . 79))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 239)\n  (:start . 230) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x973.4.1) (:span 203 210)))\n (:nscopes ((:id . :x973.4.1) (:span 203 239)))\n (:identifiers (:sid . :s973.4) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009110@unknown@formal@none@1@S@NF-kappaB activation was very effective when cells were subjected to hyperthermia before being treated with HOCl.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hyperthermia") (:form . "hyperthermia") (:end . 81)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s973.6) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009111@unknown@formal@none@1@S@Various antioxidants, such as pyrrolidine dithiocarbamate, p-bromophenacyl-bromide and nordihydroguaiaretic acid could strongly reduce NF-kappaB translocation, demonstrating the importance of oxidative species in the transduction mechanism.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 57) (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p-bromophenacyl-bromide")\n  (:form . "p-bromophenacyl-bromide") (:end . 82) (:start . 59) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nordihydroguaiaretic")\n  (:form . "nordihydroguaiaretic") (:end . 107) (:start . 87) (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 112) (:start . 108)\n  (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 118)\n  (:start . 113) (:id . 54))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 127)\n  (:start . 119) (:id . 55))\n ((:tag . "VB") (:stem . "reduce") (:form . "reduce") (:end . 134)\n  (:start . 128) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 144)\n  (:start . 135) (:id . 57))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 158) (:start . 145) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 173) (:start . 160) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 61))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 188)\n  (:start . 178) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 201)\n  (:start . 192) (:id . 64))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 209)\n  (:start . 202) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 229)\n  (:start . 217) (:id . 68))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 239)\n  (:start . 230) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s973.7) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009112@unknown@formal@none@1@S@Moreover, ACH-2 cells treated with HOCl or H2O2 released tumour necrosis factor-alpha (TNF-alpha) in the supernatants.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "release") (:form . "released") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 85)\n  (:start . 73) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 117)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s973.8) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009113@unknown@formal@none@1@S@The importance of TNF-alpha release in NF-kappaB induction by HOCl or H2O2 was demonstrated by the fact that: (1) the nuclear appearance of NF-kappaB was promoted in untreated cells; and (2) synergism between TNF-alpha and HOCl was detected.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 125)\n  (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 136)\n  (:start . 126) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 149)\n  (:start . 140) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "untreated") (:form . "untreated") (:end . 175)\n  (:start . 166) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 76))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 189) (:start . 188)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 78))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 200)\n  (:start . 191) (:id . 79))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 208)\n  (:start . 201) (:id . 80))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 218)\n  (:start . 209) (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 222) (:start . 219)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 227) (:start . 223)\n  (:id . 83))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 231) (:start . 228)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 240)\n  (:start . 232) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s973.9) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009114@unknown@formal@none@1@S@Collectively, these results suggest that HOCl should be considered as an oxidative species capable of inducing NF-kappaB in a T-lymphocytic cell line through a transduction mechanism involving ROS, and having a long-distance effect through subsequent TNF-alpha release.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HOCl") (:form . "HOCl") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "t-lymphocytic") (:form . "T-lymphocytic")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 172)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 182)\n  (:start . 173) (:id . 68))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 192)\n  (:start . 183) (:id . 69))\n ((:tag . "NNS") (:stem . "ros") (:form . "ROS") (:end . 196) (:start . 193)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 208)\n  (:start . 202) (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 210) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "long-distance") (:form . "long-distance")\n  (:end . 224) (:start . 211) (:id . 75))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 231)\n  (:start . 225) (:id . 76))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 239)\n  (:start . 232) (:id . 77))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 250)\n  (:start . 240) (:id . 78))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 260)\n  (:start . 251) (:id . 79))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 268)\n  (:start . 261) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x973.10.1) (:span 46 52))\n  ((:id . :x973.10.2) (:span 28 35)))\n (:hscopes ((:id . :x973.10.1) (:span 46 268))\n  ((:id . :x973.10.2) (:span 28 268)))\n (:identifiers (:sid . :s973.10) (:did . :|9032466|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009115@unknown@formal@none@1@S@Thymocytes control the CD4 gene differently from mature T lymphocytes.@(((:tag . "NNS") (:stem . "thymocyte") (:form . "Thymocytes") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s974.1) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009116@unknown@formal@none@1@S@We analyzed the activity of the enhancer, the promoter and the silencer of the human CD4 gene during T cell development using transgenic mice.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 119)\n  (:start . 108) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 125) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 136)\n  (:start . 126) (:id . 65))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 141)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s974.2) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009117@unknown@formal@none@1@S@Immunofluorescence studies on thymic populations of mice carrying transgenes in various combinations of these regulatory DNA elements revealed that thymocytes control the CD4 gene in a different manner than mature peripheral T lymphocytes.@(((:tag . "NNP") (:stem . "Immunofluorescence") (:form . "Immunofluorescence")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "transgene") (:form . "transgenes") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 100)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 109)\n  (:start . 104) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 133)\n  (:start . 125) (:id . 58))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 142)\n  (:start . 134) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 158)\n  (:start . 148) (:id . 61))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 166)\n  (:start . 159) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 174) (:start . 171)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 179) (:start . 175)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 194)\n  (:start . 185) (:id . 68))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 201)\n  (:start . 195) (:id . 69))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 206) (:start . 202)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 213)\n  (:start . 207) (:id . 71))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 224)\n  (:start . 214) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 226) (:start . 225)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 238)\n  (:start . 227) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s974.3) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009118@unknown@formal@none@1@S@The 5'-positive regulatory unit, consisting of the promoter and the 5' enhancer, is already active at the CD4-CD8-double-negative (DN) stage of development.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "5'-positive") (:form . "5'-positive") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 91)\n  (:start . 84) (:id . 58))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cd4-cd8-double-negative")\n  (:form . "CD4-CD8-double-negative") (:end . 129) (:start . 106) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dn") (:form . "DN") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 155)\n  (:start . 144) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s974.4) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009120@unknown@formal@none@1@S@The other studied regulatory element is the minimal CD4 silencer which inhibits CD4 gene expression in peripheral CD8 T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 131)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s974.6) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009121@unknown@formal@none@1@S@This silencer is inactive in the most immature DN thymocytes, which probably use a distinct silencer mechanism to down-regulate CD4 gene expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "dn") (:form . "DN") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "VB") (:stem . "down-regulate") (:form . "down-regulate")\n  (:end . 127) (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x974.7.1) (:span 68 76)))\n (:hscopes ((:id . :x974.7.1) (:span 68 147)))\n (:identifiers (:sid . :s974.7) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009122@unknown@formal@none@1@S@Unexpectedly, the CD4 silencer is also active in CD4+ CD8int/- cells of the thymus, implying that an anti-silencer may be required to resume CD4 expression in this cell population.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd8int/-") (:form . "CD8int/-") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "imply") (:form . "implying") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "anti-silencer") (:form . "anti-silencer")\n  (:end . 114) (:start . 101) (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "VB") (:stem . "resume") (:form . "resume") (:end . 140)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 163) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 179)\n  (:start . 169) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x974.8.1) (:span 115 118))\n  ((:id . :x974.8.2) (:span 84 92)))\n (:hscopes ((:id . :x974.8.1) (:span 98 179))\n  ((:id . :x974.8.2) (:span 84 179)))\n (:identifiers (:sid . :s974.8) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009123@unknown@formal@none@1@S@Altogether, the CD4 gene is regulated by several positive and negative regulatory mechanisms which come into play in a developmentally coordinated manner.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "come") (:form . "come") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "play") (:form . "play") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 134) (:start . 119) (:id . 62))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 146)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 153)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s974.9) (:did . :|9043959|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009124@unknown@formal@none@1@S@Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.@(((:tag . "JJ") (:stem . "immune") (:form . "Immune") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hyperactivation") (:form . "hyperactivation")\n  (:end . 22) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 40) (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s975.1) (:did . :|9045614|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009125@unknown@formal@none@1@S@Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus-type") (:form . "virus-type") (:end . 33)\n  (:start . 23) (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "hyperactivation") (:form . "hyperactivation")\n  (:end . 115) (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s975.2) (:did . :|9045614|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009126@unknown@formal@none@1@S@Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 103) (:start . 90) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 184)\n  (:start . 175) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s975.3) (:did . :|9045614|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009127@unknown@formal@none@1@S@Expression of the HIV-1 transactivator Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 38) (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "recapitulate") (:form . "recapitulated")\n  (:end . 56) (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 105)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 149) (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 158) (:start . 155)\n  (:id . 63))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s975.4) (:did . :|9045614|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009128@unknown@formal@none@1@S@IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "superinduction") (:form . "superinduction")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 58) (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd28-responsive") (:form . "CD28-responsive")\n  (:end . 101) (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 151)\n  (:start . 140) (:id . 65))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 205)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 210) (:start . 206)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 217) (:start . 214)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s975.5) (:did . :|9045614|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009130@unknown@formal@none@1@S@The possible clinical use of the methyl xanthine derivative, pentoxifylline (PF), for the treatment of T cell-dependent diseases is being noted with increasing interest.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "methyl") (:form . "methyl") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "xanthine") (:form . "xanthine") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pentoxifylline") (:form . "pentoxifylline")\n  (:end . 75) (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cell-dependent") (:form . "cell-dependent")\n  (:end . 119) (:start . 105) (:id . 62))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 137) (:start . 132)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 159)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x976.2.1) (:span 4 12)))\n (:hscopes ((:id . :x976.2.1) (:span 4 128)))\n (:identifiers (:sid . :s976.2) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009131@unknown@formal@none@1@S@In this paper, we studied the molecular consequences of PF treatment during lymphocyte activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 39)\n  (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 52)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s976.3) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009132@unknown@formal@none@1@S@We found that in T cells, anti-CD3-induced c-Rel expression was blocked by PF, whereas the induction of other NF-kappaB family members was not significantly affected.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-cd3-induced") (:form . "anti-CD3-induced")\n  (:end . 42) (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 156) (:start . 143) (:id . 67))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s976.4) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009133@unknown@formal@none@1@S@However, induction of NF-AT, which has the same signaling requirements as c-Rel induction, was not inhibited by PF.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x976.5.1) (:span 95 98)))\n (:nscopes ((:id . :x976.5.1) (:span 9 114)))\n (:identifiers (:sid . :s976.5) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009134@unknown@formal@none@1@S@Among genes that respond to these transcription factors, IL-2 mRNA induction was suppressed by PF, whereas IL-2R(alpha) chain mRNA induction was not affected.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "JJ") (:stem . "IL-2R(alpha)") (:form . "IL-2R(alpha)") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x976.6.1) (:span 145 148)))\n (:nscopes ((:id . :x976.6.1) (:span 107 157)))\n (:identifiers (:sid . :s976.6) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009135@unknown@formal@none@1@S@These observations implicated c-Rel as an IL-2 promoter factor, for which experimental support was obtained from transient transfection experiments.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "implicate") (:form . "implicated") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 135)\n  (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 147)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s976.7) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009136@unknown@formal@none@1@S@In contrast with the observation in T cells, c-Rel induction was not blocked by PF in B cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x976.8.1) (:span 65 68)))\n (:nscopes ((:id . :x976.8.1) (:span 45 93)))\n (:identifiers (:sid . :s976.8) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009137@unknown@formal@none@1@S@The greater selectivity of PF, compared with FK506, at both the molecular and cellular levels may prove advantageous in manipulating T cell responses in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "selectivity") (:form . "selectivity") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PF") (:form . "PF") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "FK506") (:form . "FK506") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 73)\n  (:start . 64) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "advantageous") (:form . "advantageous") (:end . 116)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "manipulate") (:form . "manipulating") (:end . 132)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 149)\n  (:start . 140) (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x976.9.1) (:span 94 97)))\n (:hscopes ((:id . :x976.9.1) (:span 94 157)))\n (:identifiers (:sid . :s976.9) (:did . :|9047238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009138@unknown@formal@none@1@S@A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 3) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 17) (:start . 4) (:id . 44))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-3") (:form . "interleukin-3")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "RB") (:stem . "cooperatively") (:form . "cooperatively")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "JJ") (:stem . "i-hypersensitive") (:form . "I-hypersensitive")\n  (:end . 137) (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s977.1) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009140@unknown@formal@none@1@S@Here we identified an inducible T cell-specific enhancer 14 kb upstream of the IL-3 gene that responded to activation of T cell receptor signaling pathways.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s977.3) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009141@unknown@formal@none@1@S@The IL-3 enhancer spanned an inducible cyclosporin A-sensitive DNase I-hypersensitive site found only in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "span") (:form . "spanned") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "a-sensitive") (:form . "A-sensitive") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "i-hypersensitive") (:form . "I-hypersensitive")\n  (:end . 85) (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s977.4) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009142@unknown@formal@none@1@S@Four NFAT-like elements exist within the enhancer.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nfat-like") (:form . "NFAT-like") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s977.5) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009143@unknown@formal@none@1@S@The two most active NFAT-like elements were located at the center of the DNase I-hypersensitive site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "nfat-like") (:form . "NFAT-like") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "i-hypersensitive") (:form . "I-hypersensitive")\n  (:end . 95) (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s977.6) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009144@unknown@formal@none@1@S@One of these NFAT-like elements encompassed overlapping Oct- and NFATp/c-binding sites, which functioned in a highly synergistic manner.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nfat-like") (:form . "NFAT-like") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "encompass") (:form . "encompassed") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "oct-") (:form . "Oct-") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nfatp/c-binding") (:form . "NFATp/c-binding")\n  (:end . 80) (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "function") (:form . "functioned") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 128)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s977.7) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009145@unknown@formal@none@1@S@We suggest that the T cell-specific expression of the IL-3 gene is partly controlled through the enhancer by cooperation between Oct and NFAT family proteins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-3") (:form . "IL-3") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 148)\n  (:start . 142) (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x977.8.1) (:span 3 10)))\n (:hscopes ((:id . :x977.8.1) (:span 3 157)))\n (:identifiers (:sid . :s977.8) (:did . :|9047239|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009146@unknown@formal@none@1@S@A negative regulatory region containing a glucocorticosteroid response element (nGRE) in the human interleukin-1beta gene.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticosteroid")\n  (:form . "glucocorticosteroid") (:end . 61) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ngre") (:form . "nGRE") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 116) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s978.1) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009147@unknown@formal@none@1@S@Interleukin-1 beta (IL-1beta) is one of the most important inflammatory mediators in human inflammatory and immunological diseases.@(((:tag . "NN") (:stem . "interleukin-1") (:form . "Interleukin-1")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 103)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s978.2) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009148@unknown@formal@none@1@S@The regulation of human IL-1beta gene expression has been studied for several years, and a few regulatory elements have been discovered in the promoter region.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 158)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s978.3) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009150@unknown@formal@none@1@S@We have identified a negative regulatory element located in the region between -685 and -395.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "CD") (:stem . "-685") (:form . "-685") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-395") (:form . "-395") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s978.5) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009151@unknown@formal@none@1@S@Within this region, a 19-bp nuclear factor binding site (-570 to -552) was characterized by DNase I footprinting and electromobility shift assay.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "19-bp") (:form . "19-bp") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-570") (:form . "-570") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-552") (:form . "-552") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 88) (:start . 75) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 112)\n  (:start . 100) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "electromobility") (:form . "electromobility")\n  (:end . 132) (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s978.6) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009152@unknown@formal@none@1@S@A consensus sequence for a negative glucocorticoid response element (nGRE) and a transcription activator protein-2 binding site were noted within this footprint.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 50) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "nGRE") (:form . "nGRE") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "protein-2") (:form . "protein-2") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s978.7) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009153@unknown@formal@none@1@S@Functional studies showed a 2.5-fold increase in promoter activity when this 19-bp binding site was deleted in the reporter constructs IL-1beta/CAT and IL-1beta/SV40 promoter/CAT.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 25) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "2.5-fold") (:form . "2.5-fold") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "19-bp") (:form . "19-bp") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . "NNP") (:stem . "IL-1beta/CAT") (:form . "IL-1beta/CAT")\n  (:end . 147) (:start . 135) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-1beta/SV40") (:form . "IL-1beta/SV40")\n  (:end . 165) (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "promoter/cat") (:form . "promoter/CAT") (:end . 178)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s978.8) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009154@unknown@formal@none@1@S@Dexamethasone (10(-8) M) repressed chloramphenicol acetyltransferase (CAT) production by 75% in the wild-type fragment but not in a deletion mutant lacking the 19-bp site.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "10(-8)") (:form . "10(-8)") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "repress") (:form . "repressed") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 50) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 68) (:start . 51) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "19-bp") (:form . "19-bp") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x978.9.1) (:span 148 155))\n  ((:id . :x978.9.2) (:span 123 126)))\n (:nscopes ((:id . :x978.9.1) (:span 148 170))\n  ((:id . :x978.9.2) (:span 123 170)))\n (:identifiers (:sid . :s978.9) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009155@unknown@formal@none@1@S@A protein of about 150 kD that bound to this negative regulatory sequence was identified by UV cross-linking.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kd") (:form . "kD") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 53)\n  (:start . 45) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 64)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s978.10) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009156@unknown@formal@none@1@S@This is the first description of a negative regulatory region responsive to glucocorticoids in a cytokine gene.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "description") (:form . "description") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 91) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s978.11) (:did . :|9052735|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009157@unknown@formal@none@1@S@TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).@(((:tag . "NN") (:stem . "tramp") (:form . "TRAMP") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "apoptosis-mediating")\n  (:form . "apoptosis-mediating") (:end . 34) (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "CD") (:stem . "Fas(Apo-1/CD95)") (:form . "Fas(Apo-1/CD95)")\n  (:end . 122) (:start . 107) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s979.1) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009158@unknown@formal@none@1@S@A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 77)\n  (:start . 67) (:id . 56))\n ((:tag . "NNP") (:stem . "TRAMP") (:form . "TRAMP") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 93) (:start . 89)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 104)\n  (:start . 94) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s979.2) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009160@unknown@formal@none@1@S@TRAMP is abundantly expressed on thymocytes and lymphocytes.@(((:tag . "NN") (:stem . "tramp") (:form . "TRAMP") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s979.4) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009161@unknown@formal@none@1@S@Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cysteine-rich") (:form . "cysteine-rich")\n  (:end . 58) (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s979.5) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009162@unknown@formal@none@1@S@Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TRAMP") (:form . "TRAMP") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s979.6) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009163@unknown@formal@none@1@S@TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2.@(((:tag . "JJ") (:stem . "tramp-induced") (:form . "TRAMP-induced")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ice-like") (:form . "ICE-like") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x979.7.1) (:span 81 84)))\n (:nscopes ((:id . :x979.7.1) (:span 81 93)))\n (:identifiers (:sid . :s979.7) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009164@unknown@formal@none@1@S@In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TRAMP") (:form . "TRAMP") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "apoptosis-inducing") (:form . "apoptosis-inducing")\n  (:end . 87) (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x979.8.2) (:span 28 34)))\n (:ncues ((:id . :x979.8.1) (:span 24 27)))\n (:hscopes ((:id . :x979.8.2) (:span 13 113)))\n (:nscopes ((:id . :x979.8.1) (:span 13 113)))\n (:identifiers (:sid . :s979.8) (:did . :|9052839|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009165@unknown@formal@none@1@S@Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Egr-1/RelA") (:form . "Egr-1/RelA") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "distinguish") (:form . "distinguishing")\n  (:end . 51) (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "JJ") (:stem . "factor-alpha-induced")\n  (:form . "factor-alpha-induced") (:end . 110) (:start . 90) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 55))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 122) (:start . 120)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s980.1) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009166@unknown@formal@none@1@S@NF-kappa B is an important transcription factor required for T cell proliferation and other immunological functions.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immunological") (:form . "immunological")\n  (:end . 105) (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s980.2) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009167@unknown@formal@none@1@S@The NF-kappa B1 gene encodes a 105-kD protein that is the precursor of the p50 component of NF-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "105-kd") (:form . "105-kD") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s980.3) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009168@unknown@formal@none@1@S@Previously, we and others have demonstrated that NF-kappa B regulates the NF-kappa B1 gene.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 43)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s980.4) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009170@unknown@formal@none@1@S@Characterization of the NF-kappa B1 promoter identified an Egr-1 site which was found to be essential for both the PMA/PHA-mediated induction as well as the synergistic activation observed after the expression of the RelA subunit of NF-kappa B and Egr-1.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pma/pha-mediated") (:form . "PMA/PHA-mediated")\n  (:end . 131) (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 141)\n  (:start . 132) (:id . 62))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 168)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 179)\n  (:start . 169) (:id . 68))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 188)\n  (:start . 180) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 209)\n  (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 221) (:start . 217)\n  (:id . 75))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 229)\n  (:start . 222) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 241)\n  (:start . 233) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 243) (:start . 242)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 253)\n  (:start . 248) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s980.6) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009171@unknown@formal@none@1@S@Furthermore, Egr-1 induction was required for endogenous NF-kappa B1 gene expression, since PMA/PHA-stimulated T cell lines expressing antisense Egr-1 RNA were inhibited in their ability to upregulate NF-kappa B1 transcription.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pma/pha-stimulated") (:form . "PMA/PHA-stimulated")\n  (:end . 110) (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 144)\n  (:start . 135) (:id . 61))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 178)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 186)\n  (:start . 179) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 69))\n ((:tag . "VB") (:stem . "upregulate") (:form . "upregulate") (:end . 200)\n  (:start . 190) (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 209)\n  (:start . 201) (:id . 71))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 212) (:start . 210)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 226) (:start . 213) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s980.7) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009172@unknown@formal@none@1@S@Our studies indicate that transcriptional synergy mediated by activation of both Egr-1 and NF-kappa B may have important ramifications in T cell development by upregulating NF-kappa B1 gene expression.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "ramification") (:form . "ramifications")\n  (:end . 134) (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 156)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "upregulate") (:form . "upregulating") (:end . 172)\n  (:start . 160) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 181)\n  (:start . 173) (:id . 67))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 184) (:start . 182)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 200)\n  (:start . 190) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x980.8.1) (:span 102 105))\n  ((:id . :x980.8.2) (:span 12 25)))\n (:hscopes ((:id . :x980.8.1) (:span 102 200))\n  ((:id . :x980.8.2) (:span 12 200)))\n (:identifiers (:sid . :s980.8) (:did . :|9053449|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009173@unknown@formal@none@1@S@Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action.@(((:tag . "NNP") (:stem . "Differentiation") (:form . "Differentiation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ICRF-193") (:form . "ICRF-193") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "antitumour") (:form . "antitumour") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "topoisomerase") (:form . "topoisomerase")\n  (:end . 103) (:start . 90) (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 153)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s981.1) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009174@unknown@formal@none@1@S@We have compared the action on U-937 human promonocytic leukemia cells of two DNA topoisomerase II inhibitors, namely the epipodophyllotoxin etoposide and the bisdioxopiperazine ICRF-193.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 55)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "topoisomerase") (:form . "topoisomerase")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "epipodophyllotoxin") (:form . "epipodophyllotoxin")\n  (:end . 140) (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "bisdioxopiperazine") (:form . "bisdioxopiperazine")\n  (:end . 177) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "icrf-193") (:form . "ICRF-193") (:end . 186)\n  (:start . 178) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s981.2) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009175@unknown@formal@none@1@S@One hour pulse-treatment with 3 microM etoposide caused topoisomerase associated, primary DNA breakage, which was rapidly followed by apoptosis.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pulse-treatment") (:form . "pulse-treatment")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "topoisomerase") (:form . "topoisomerase")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "breakage") (:form . "breakage") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s981.3) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009176@unknown@formal@none@1@S@By contrast, these effects were not observed upon pulse-treatment with 6 microM ICRF-193.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pulse-treatment") (:form . "pulse-treatment")\n  (:end . 65) (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "icrf-193") (:form . "ICRF-193") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x981.4.1) (:span 32 35)))\n (:nscopes ((:id . :x981.4.1) (:span 13 88)))\n (:identifiers (:sid . :s981.4) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009177@unknown@formal@none@1@S@However, continuous treatments with subcytotoxic concentrations of etoposide (0.15 microM) and ICRF-193 (0.3 microM) produced several similar effects, namely decreased cell proliferation, accumulation of cells at G2, increase in cell mass, and induction of differentiation.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "treatment") (:form . "treatments") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "subcytotoxic") (:form . "subcytotoxic") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 63) (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "CD") (:stem . "0.15") (:form . "0.15") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ICRF-193") (:form . "ICRF-193") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "CD") (:stem . "0.3") (:form . "0.3") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 157)\n  (:start . 151) (:id . 66))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 186) (:start . 173) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 200)\n  (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 209)\n  (:start . 204) (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "NN") (:stem . "g2") (:form . "G2") (:end . 215) (:start . 213)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 225)\n  (:start . 217) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 233) (:start . 229)\n  (:id . 79))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 238) (:start . 234)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 82))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 253)\n  (:start . 244) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 256) (:start . 254)\n  (:id . 84))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 272) (:start . 257) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s981.5) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009178@unknown@formal@none@1@S@Under these conditions, etoposide produced a biphasic activation of protein kinase C, which consisted in an early transient activation (from hours 1 to 6) of the membrane-bound enzyme followed by a later activation (hour 48) of the total, membrane-bound and cytosolic enzyme.@(((:tag . "IN") (:stem . "under") (:form . "Under") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "etoposide") (:form . "etoposide") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . 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5009180@unknown@formal@none@1@S@When used at differentiation-inducing concentrations, both topoisomerase inhibitors caused a great stimulation of AP-1 binding activity, with maximum value at hour 12 in etoposide-treated cells and at hour 48 in ICRF-193-treated cells.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "differentiation-inducing")\n  (:form . "differentiation-inducing") (:end . 37) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 52) (:start . 38) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "topoisomerase") (:form . "topoisomerase")\n  (:end . 72) (:start . 59) (:id . 49))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 83)\n  (:start . 73) (:id . 50))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 90)\n  (:start . 84) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 98) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 110)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 118) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 126)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 149)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "etoposide-treated") (:form . "etoposide-treated")\n  (:end . 187) (:start . 170) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 193)\n  (:start . 188) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 69))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 205) (:start . 201)\n  (:id . 71))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "icrf-193-treated") (:form . "ICRF-193-treated")\n  (:end . 228) (:start . 212) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 234)\n  (:start . 229) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s981.8) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009181@unknown@formal@none@1@S@By contrast, the binding activity of the NF-kappa(B) and EGR-1 transcription factors was little affected.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "NF-kappa(B)") (:form . "NF-kappa(B)") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "egr-1") (:form . "EGR-1") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "little") (:form . "little") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s981.9) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009182@unknown@formal@none@1@S@It is concluded that topoisomerase II inhibitors may induce the differentiation of promonocytic cells, independently of their capacity to cause DNA strand breaks.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "topoisomerase") (:form . "topoisomerase")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 79) (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 95)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 134)\n  (:start . 126) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 143)\n  (:start . 138) (:id . 62))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 154)\n  (:start . 148) (:id . 64))\n ((:tag . "NNS") (:stem . "break") (:form . "breaks") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x981.10.1) (:span 49 52)))\n (:hscopes ((:id . :x981.10.1) (:span 49 161)))\n (:identifiers (:sid . :s981.10) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009183@unknown@formal@none@1@S@However, there are other effects, such as the early activation of protein kinase C, which are probably derived from the production of primary DNA breakage by some anti-topoisomerase drugs.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 130)\n  (:start . 120) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "breakage") (:form . "breakage") (:end . 154)\n  (:start . 146) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "anti-topoisomerase") (:form . "anti-topoisomerase")\n  (:end . 181) (:start . 163) (:id . 72))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 187)\n  (:start . 182) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x981.11.1) (:span 94 102)))\n (:hscopes ((:id . :x981.11.1) (:span 84 187)))\n (:identifiers (:sid . :s981.11) (:did . :|9057086|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009184@unknown@formal@none@1@S@Nuclear Rel-A and c-Rel protein complexes are differentially distributed within human thymocytes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Rel-A") (:form . "Rel-A") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 60) (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 72)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s982.1) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009185@unknown@formal@none@1@S@Nuclear factor-kappa B (NF-kappa B)/Rel proteins are inducible transcriptional regulators of numerous cellular genes.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B)/Rel") (:form . "B)/Rel") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 78) (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 101)\n  (:start . 93) (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 116)\n  (:start . 111) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s982.2) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009186@unknown@formal@none@1@S@They are particularly abundant in lymphoid tissues and are thought to be critical for the transcription of genes involved in immune and inflammatory responses.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 148)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x982.3.1) (:span 59 66)))\n (:hscopes ((:id . :x982.3.1) (:span 55 158)))\n (:identifiers (:sid . :s982.3) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009187@unknown@formal@none@1@S@We have reported previously that a nuclear NF-kappa B activity was present in freshly extracted human thymocytes in the absence of in vitro treatment of these cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x982.4.1) (:span 120 127)))\n (:nscopes ((:id . :x982.4.1) (:span 120 164)))\n (:identifiers (:sid . :s982.4) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009188@unknown@formal@none@1@S@In the present report, we identified NF-kappa B proteins extracted from human thymocyte nuclei as being p50/p65 and p50/c-Rel complexes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50/c-rel") (:form . "p50/c-Rel") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s982.5) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009190@unknown@formal@none@1@S@This detection suggested a preferential activation of p50/c-Rel in medullary thymocytes, whereas p50/p65 was present in both cortical and medullary regions of human thymus lobules.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "preferential") (:form . "preferential") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50/c-rel") (:form . "p50/c-Rel") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "medullary") (:form . "medullary") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cortical") (:form . "cortical") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "medullary") (:form . "medullary") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 155)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 164)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 171)\n  (:start . 165) (:id . 66))\n ((:tag . "NNS") (:stem . "lobule") (:form . "lobules") (:end . 179)\n  (:start . 172) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x982.7.1) (:span 15 24)))\n (:hscopes ((:id . :x982.7.1) (:span 15 87)))\n (:identifiers (:sid . :s982.7) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009191@unknown@formal@none@1@S@However, the intensity of p65 labeling was much higher in several thymocytes from the medulla.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "intensity") (:form . "intensity") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "labeling") (:form . "labeling") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 54) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "medulla") (:form . "medulla") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s982.8) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009192@unknown@formal@none@1@S@p65, p50, and c-Rel activities were found in both CD4- and CD8-positive thymocytes.@(((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 19) (:start . 14)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 30)\n  (:start . 20) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd4-") (:form . "CD4-") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd8-positive") (:form . "CD8-positive") (:end . 71)\n  (:start . 59) (:id . 55))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 82)\n  (:start . 72) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s982.9) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009193@unknown@formal@none@1@S@These observations suggest that p65 and c-Rel complexes play distinct roles in gene expression and that both forms of NF-kappa B play critical roles during late stages of the intrathymic maturation of T cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "intrathymic") (:form . "intrathymic") (:end . 186)\n  (:start . 175) (:id . 71))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 197)\n  (:start . 187) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 208)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x982.10.1) (:span 19 26)))\n (:hscopes ((:id . :x982.10.1) (:span 19 208)))\n (:identifiers (:sid . :s982.10) (:did . :|9058790|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009194@unknown@formal@none@1@S@Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.@(((:tag . "NNP") (:stem . "Alteration") (:form . "Alteration") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "VBZ") (:stem . "separate") (:form . "separates") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 132) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 158)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s983.1) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009195@unknown@formal@none@1@S@The ZEBRA protein from Epstein-Barr virus (EBV) activates a switch from the latent to the lytic expression program of the virus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s983.2) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009196@unknown@formal@none@1@S@ZEBRA, a member of the bZIP family of DNA-binding proteins, is a transcriptional activator capable of inducing expression from viral lytic cycle promoters.@(((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bzip") (:form . "bZIP") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 34)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 49)\n  (:start . 38) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 80) (:start . 65) (:id . 56))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 154)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s983.3) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009197@unknown@formal@none@1@S@It had previously been thought that ZEBRA's capacity to disrupt EBV latency resided primarily in its ability to activate transcription of genes that encode products required for lytic replication.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "VBD") (:stem . "reside") (:form . "resided") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 134) (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 195)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x983.4.1) (:span 23 30)))\n (:hscopes ((:id . :x983.4.1) (:span 23 195)))\n (:identifiers (:sid . :s983.4) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009198@unknown@formal@none@1@S@We generated a point mutant of ZEBRA, Z(S186A), that was not impaired in its ability to activate transcription; however, this mutation abolished its ability to initiate the viral lytic cascade.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Z(S186A)") (:form . "Z(S186A)") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 69)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 84)\n  (:start . 77) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 96)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 134)\n  (:start . 126) (:id . 66))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 144)\n  (:start . 135) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 156)\n  (:start . 149) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 178)\n  (:start . 173) (:id . 73))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 192)\n  (:start . 185) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x983.5.1) (:span 57 60)))\n (:nscopes ((:id . :x983.5.1) (:span 48 110)))\n (:identifiers (:sid . :s983.5) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009200@unknown@formal@none@1@S@Therefore, initiation of the EBV lytic cycle by the ZEBRA protein requires a function in addition to transcriptional activation; a change of serine 186 to alanine in the DNA-binding domain of ZEBRA abolished this additional function and uncovered a new role for the ZEBRA protein in disruption of EBV latency.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . 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"alanine") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 181)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 188)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "ZEBRA") (:form . "ZEBRA") (:end . 197)\n  (:start . 192) (:id . 75))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 207)\n  (:start . 198) (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 212) (:start . 208)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 223)\n  (:start . 213) (:id . 78))\n ((:tag . "NN") (:stem . "function") (:form . 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"in") (:end . 282) (:start . 280)\n  (:id . 89))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 293)\n  (:start . 283) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 296) (:start . 294)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 300) (:start . 297)\n  (:id . 92))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 308)\n  (:start . 301) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s983.7) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009201@unknown@formal@none@1@S@The additional function that is required for initiation of the lytic viral life cycle is likely to require phosphorylation of serine 186 of the ZEBRA protein, which may influence either DNA recognition or transcriptional activation of lytic viral promoters in a chromatinized viral episome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . 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(:end . 290) (:start . 289)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x983.8.1) (:span 165 168))\n  ((:id . :x983.8.2) (:span 89 95)))\n (:hscopes ((:id . :x983.8.1) (:span 165 289))\n  ((:id . :x983.8.2) (:span 0 289)))\n (:identifiers (:sid . :s983.8) (:did . :|9060666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009202@unknown@formal@none@1@S@Activation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-stimulated")\n  (:form . "lipopolysaccharide-stimulated") (:end . 81) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 86) (:start . 82)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s984.1) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009203@unknown@formal@none@1@S@During the course of serious bacterial infections, lipopolysaccharide (LPS) interacts with monocyte/macrophage receptors, resulting in the generation of inflammatory cytokines.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "serious") (:form . "serious") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 69) (:start . 51) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 110) (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 149)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 165)\n  (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 175)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s984.2) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009204@unknown@formal@none@1@S@Transcription factor NF-kappaB is crucial in activating the transcription of genes encoding proinflammatory cytokines.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 107) (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 117)\n  (:start . 108) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s984.3) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009205@unknown@formal@none@1@S@In this paper, we demonstrate that the activation of NF-kappaB by LPS in a promonocytic cell line (U937) followed a rather slow kinetics, depending on the rate of IkappaB-alpha inhibitor hydrolysis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 87)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "follow") (:form . "followed") (:end . 113)\n  (:start . 105) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 122)\n  (:start . 116) (:id . 65))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 127) (:start . 123)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 136)\n  (:start . 128) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 147)\n  (:start . 138) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 159) (:start . 155)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 176) (:start . 163) (:id . 74))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 186)\n  (:start . 177) (:id . 75))\n ((:tag . "NN") (:stem . "hydrolysis") (:form . "hydrolysis") (:end . 197)\n  (:start . 187) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s984.4) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009206@unknown@formal@none@1@S@No degradation of p105 and p100 inhibitors was observed under these conditions.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p100") (:form . "p100") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x984.5.1) (:span 0 2)))\n (:nscopes ((:id . :x984.5.1) (:span 0 78)))\n (:identifiers (:sid . :s984.5) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009207@unknown@formal@none@1@S@The transduction pathway leading to NF-kappaB activation in U937 cells involved the intracellular generation of reactive oxygen species (ROS), as demonstrated by the concomitant inhibitory effects of antioxidants on NF-kappaB activation and the emission of a fluorescent probe reacting intracellularly with hydrogen peroxide.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . 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"concomitant") (:end . 177)\n  (:start . 166) (:id . 68))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 188)\n  (:start . 178) (:id . 69))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 196)\n  (:start . 189) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 212)\n  (:start . 200) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 215) (:start . 213)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 225)\n  (:start . 216) (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 236)\n  (:start . 226) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 77))\n ((:tag . "NN") (:stem . "emission") (:form . "emission") (:end . 253)\n  (:start . 245) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 256) (:start . 254)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 258) (:start . 257)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "fluorescent") (:form . "fluorescent") (:end . 270)\n  (:start . 259) (:id . 81))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 276)\n  (:start . 271) (:id . 82))\n ((:tag . "VBG") (:stem . "react") (:form . "reacting") (:end . 285)\n  (:start . 277) (:id . 83))\n ((:tag . "RB") (:stem . "intracellularly") (:form . "intracellularly")\n  (:end . 301) (:start . 286) (:id . 84))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 306) (:start . 302)\n  (:id . 85))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 315)\n  (:start . 307) (:id . 86))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 324)\n  (:start . 316) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5009208@unknown@formal@none@1@S@This ROS pathway was also characterized by the use of other inhibitors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s984.7) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009210@unknown@formal@none@1@S@However, the NF-kappaB activation pathway involving the acidic sphingomyelinase of the endolysosomial membrane did not seem to participate in the LPS-induced NF-kappaB activation in U937 cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "sphingomyelinase") (:form . "sphingomyelinase")\n  (:end . 79) (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endolysosomial") (:form . "endolysosomial")\n  (:end . 101) (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 110)\n  (:start . 102) (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "VB") (:stem . "seem") (:form . "seem") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 157)\n  (:start . 146) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 167)\n  (:start . 158) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 178)\n  (:start . 168) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 66))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 186) (:start . 182)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 192)\n  (:start . 187) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x984.9.2) (:span 119 123)))\n (:ncues ((:id . :x984.9.1) (:span 115 118)))\n (:hscopes ((:id . :x984.9.2) (:span 9 192)))\n (:nscopes ((:id . :x984.9.1) (:span 9 192)))\n (:identifiers (:sid . :s984.9) (:did . :|9065737|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009211@unknown@formal@none@1@S@Possible role of nuclear factor-kappa B activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line.@(((:tag . "JJ") (:stem . "possible") (:form . "Possible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 84) (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x985.1.1) (:span 0 8)))\n (:hscopes ((:id . :x985.1.1) (:span 0 124)))\n (:identifiers (:sid . :s985.1) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009212@unknown@formal@none@1@S@Nuclear factor-kappa B (NF-kappa B) plays a broad role in gene regulation, but it is not evident whether NF-kappa B acts as a messenger system for germline C epsilon transcription.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "broad") (:form . "broad") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 73)\n  (:start . 63) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 96)\n  (:start . 89) (:id . 61))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 104)\n  (:start . 97) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 113)\n  (:start . 105) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 67))\n ((:tag . "NN") (:stem . "messenger") (:form . "messenger") (:end . 135)\n  (:start . 126) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 142)\n  (:start . 136) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 70))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 155)\n  (:start . 147) (:id . 71))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 157) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 165)\n  (:start . 158) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x985.2.1) (:span 97 104)) ((:id . :x985.2.2) (:span 85 96)))\n (:hscopes ((:id . :x985.2.1) (:span 97 179))\n  ((:id . :x985.2.2) (:span 85 179)))\n (:identifiers (:sid . :s985.2) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009213@unknown@formal@none@1@S@We report here that the signaling cascade triggered by interleukin-4 (IL-4) or anti-CD40 monoclonal antibody (mAb) participates in NF-kappa B activation responsible for germline C epsilon transcription in a human Burkitt lymphoma B cell line, DND39.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "participate") (:form . "participates") (:end . 127)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 164)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 201) (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 206) (:start . 205)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 212)\n  (:start . 207) (:id . 75))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 220)\n  (:start . 213) (:id . 76))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 229)\n  (:start . 221) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 231) (:start . 230)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 236) (:start . 232)\n  (:id . 79))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 241) (:start . 237)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 242) (:start . 241)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "DND39") (:form . "DND39") (:end . 248)\n  (:start . 243) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s985.3) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009214@unknown@formal@none@1@S@Both IL-4 and anti-CD40 mAb induced activation of phosphatidylinositol 3-kinase (PI3-kinase), translocation of a zeta isoform of protein kinase C, and nuclear expression of NF-kappa B.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 70) (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PI3-kinase") (:form . "PI3-kinase") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 158)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 181)\n  (:start . 173) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s985.4) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009215@unknown@formal@none@1@S@All such events were abrogated by treatment with LY294002, a specific inhibitor of PI3-kinase.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LY294002") (:form . "LY294002") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PI3-kinase") (:form . "PI3-kinase") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s985.5) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009216@unknown@formal@none@1@S@In addition, N-acetyl-L-cysteine (NAC), a potent antioxidant, decreased NF-kappa B activation caused by IL-4, anti-CD40 mAb, or their combination.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 32) (:start . 13) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 60)\n  (:start . 49) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 133)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 145)\n  (:start . 134) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x985.6.1) (:span 125 127)))\n (:hscopes ((:id . :x985.6.1) (:span 104 145)))\n (:identifiers (:sid . :s985.6) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009217@unknown@formal@none@1@S@NAC was also effective in diminishing germline C epsilon transcription, and its potency was higher in cultures costimulated with IL-4 and anti-CD40 mAb than in those stimulated with IL-4 alone.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "diminish") (:form . "diminishing") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 98) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "VBN") (:stem . "costimulate") (:form . "costimulated") (:end . 123)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 176)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 192)\n  (:start . 187) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s985.7) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009218@unknown@formal@none@1@S@These results indicate that IL-4 and ligation of CD40 induce NF-kappa B expression via at least a mechanism dependent on the PI3-kinase pathway and suggest that NF-kappa B sensitive to NAC may play a role in regulating germline C epsilon transcription.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PI3-kinase") (:form . "PI3-kinase") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 181)\n  (:start . 172) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 204) (:start . 200)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 218)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 227)\n  (:start . 219) (:id . 79))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 229) (:start . 228)\n  (:id . 80))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 237)\n  (:start . 230) (:id . 81))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 251) (:start . 238) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x985.8.1) (:span 189 192))\n  ((:id . :x985.8.2) (:span 148 155)) ((:id . :x985.8.3) (:span 14 27)))\n (:hscopes ((:id . :x985.8.1) (:span 189 251))\n  ((:id . :x985.8.2) (:span 148 251)) ((:id . :x985.8.3) (:span 14 143)))\n (:identifiers (:sid . :s985.8) (:did . :|9070319|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009220@unknown@formal@none@1@S@The in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 29) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "filarial") (:form . "filarial") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "JJ") (:stem . "antigen-specific") (:form . "antigen-specific")\n  (:end . 80) (:start . 64) (:id . 50))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 88)\n  (:start . 81) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 101)\n  (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Wuchereria") (:form . "Wuchereria") (:end . 115)\n  (:start . 105) (:id . 55))\n ((:tag . "NN") (:stem . "banerofti") (:form . "banerofti") (:end . 125)\n  (:start . 116) (:id . 56))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 135)\n  (:start . 126) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s986.2) (:did . :|9073544|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009221@unknown@formal@none@1@S@Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04).@(((:tag . "VBG") (:stem . "circulate") (:form . "Circulating") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "filaria-induced") (:form . "filaria-induced")\n  (:end . 57) (:start . 42) (:id . 47))\n ((:tag . "JJ") (:stem . "lymphatic") (:form . "lymphatic") (:end . 67)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "pathology") (:form . "pathology") (:end . 77)\n  (:start . 68) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LP") (:form . "LP") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 100) (:start . 87) (:id . 54))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 118)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 126)\n  (:start . 119) (:id . 57))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 139)\n  (:start . 127) (:id . 58))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 145)\n  (:start . 140) (:id . 59))\n ((:tag . "NNS") (:stem . "monolayer") (:form . "monolayers") (:end . 156)\n  (:start . 146) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 161) (:start . 157)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 165) (:start . 162)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 173)\n  (:start . 166) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 178) (:start . 174)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "asymptomatic") (:form . "asymptomatic") (:end . 191)\n  (:start . 179) (:id . 65))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 200)\n  (:start . 192) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "mf") (:form . "MF") (:end . 204) (:start . 202)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 205) (:start . 204)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 217)\n  (:start . 206) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 71))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 220) (:start . 219)\n  (:id . 72))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 222) (:start . 221)\n  (:id . 73))\n ((:tag . "CD") (:stem . "0.04") (:form . "0.04") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s986.3) (:did . :|9073544|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009222@unknown@formal@none@1@S@In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MF") (:form . "MF") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 76) (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "48-hr") (:form . "48-hr") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "filarial") (:form . "filarial") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "JJ") (:stem . "stimulated") (:form . "stimulated") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LP") (:form . "LP") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 151)\n  (:start . 140) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 169) (:start . 156) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 203)\n  (:start . 194) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "48-hr") (:form . "48-hr") (:end . 212)\n  (:start . 207) (:id . 76))\n ((:tag . "JJ") (:stem . "media-stimulated") (:form . "media-stimulated")\n  (:end . 229) (:start . 213) (:id . 77))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 237)\n  (:start . 230) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x986.4.1) (:span 40 42)))\n (:nscopes ((:id . :x986.4.1) (:span 40 58)))\n (:identifiers (:sid . :s986.4) (:did . :|9073544|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009223@unknown@formal@none@1@S@In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "vla-4/vcam-1") (:form . "VLA-4/VCAM-1") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 133) (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s986.5) (:did . :|9073544|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009224@unknown@formal@none@1@S@Suppression by azelastine hydrochloride of NF-kappa B activation involved in generation of cytokines and nitric oxide.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "azelastine") (:form . "azelastine") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "hydrochloride") (:form . "hydrochloride")\n  (:end . 39) (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s987.1) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009225@unknown@formal@none@1@S@The influence of the anti-allergy agent azelastine hydrochloride (Azeptin) on NF-kappa B activation associated with the generation of cytokines and nitric oxide (NO) was investigated in various kinds of human and mouse cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti-allergy") (:form . "anti-allergy") (:end . 33)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "azelastine") (:form . "azelastine") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "hydrochloride") (:form . "hydrochloride")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Azeptin") (:form . "Azeptin") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 143)\n  (:start . 134) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 154)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 182)\n  (:start . 170) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . "NNS") (:stem . "kind") (:form . "kinds") (:end . 199)\n  (:start . 194) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 208)\n  (:start . 203) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 218)\n  (:start . 213) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 224)\n  (:start . 219) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s987.2) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009226@unknown@formal@none@1@S@Azeptin dose-dependently suppressed both DNA and protein synthesis in human gingival fibroblasts (HF) and also suppressed blastogenesis of human peripheral blood lymphocytes (PBL).@(((:tag . "NNP") (:stem . "Azeptin") (:form . "Azeptin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 24) (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 35)\n  (:start . 25) (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "gingival") (:form . "gingival") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 96)\n  (:start . 85) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HF") (:form . "HF") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "blastogenesis") (:form . "blastogenesis")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 173)\n  (:start . 162) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 178) (:start . 175)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s987.3) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009227@unknown@formal@none@1@S@Generation of tumor necrosis factor-alpha, interleukin 1-beta, granulocyte-macrophage colony-stimulating factor and interleukin-6 from 10(-5) M Azeptin-treated PBL and human monocytes (HM) was decreased to approximately 1/3 to 2/3 of the control levels.@(((:tag . "NNP") (:stem . "Generation") (:form . "Generation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "1-beta") (:form . "1-beta") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "granulocyte-macrophage") (:end . 85) (:start . 63) (:id . 51))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 104) (:start . 86) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 111)\n  (:start . 105) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 129) (:start . 116) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "10(-5)") (:form . "10(-5)") (:end . 141)\n  (:start . 135) (:id . 57))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 143) (:start . 142)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "azeptin-treated") (:form . "Azeptin-treated")\n  (:end . 159) (:start . 144) (:id . 59))\n ((:tag . "NN") (:stem . "pbl") (:form . "PBL") (:end . 163) (:start . 160)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 173)\n  (:start . 168) (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 183)\n  (:start . 174) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 185) (:start . 184)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HM") (:form . "HM") (:end . 187) (:start . 185)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 202)\n  (:start . 193) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 205) (:start . 203)\n  (:id . 69))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 219) (:start . 206) (:id . 70))\n ((:tag . "CD") (:stem . "1/3") (:form . "1/3") (:end . 223) (:start . 220)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 72))\n ((:tag . "CD") (:stem . "2/3") (:form . "2/3") (:end . 230) (:start . 227)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 75))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 245)\n  (:start . 238) (:id . 76))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 252)\n  (:start . 246) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s987.4) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009228@unknown@formal@none@1@S@In parallel with the decreased cytokine generation, each cytokine mRNA was less expressed in the presence of 10(-5) M Azeptin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "10(-5)") (:form . "10(-5)") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Azeptin") (:form . "Azeptin") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s987.5) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009230@unknown@formal@none@1@S@Being compatible with those results, Azeptin (10(-5) M) suppressed activation of NF-kappa B in PBL, HM and HF.@(((:tag . "VBG") (:stem . "be") (:form . "Being") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Azeptin") (:form . "Azeptin") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "10(-5)") (:form . "10(-5)") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HM") (:form . "HM") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HF") (:form . "HF") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s987.7) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009231@unknown@formal@none@1@S@These results appear to indicate that suppression of cytokine and NO generation by Azeptin results at least partially from the inhibition of NF-kappa B activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Azeptin") (:form . "Azeptin") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x987.8.1) (:span 24 37)) ((:id . :x987.8.2) (:span 14 20)))\n (:hscopes ((:id . :x987.8.1) (:span 24 162))\n  ((:id . :x987.8.2) (:span 0 162)))\n (:identifiers (:sid . :s987.8) (:did . :|9074948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009232@unknown@formal@none@1@S@The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-ATc") (:form . "NF-ATc") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s988.1) (:did . :|9075924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009233@unknown@formal@none@1@S@Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) infection is associated with increased levels of viral replication and burden in the peripheral blood and lymphoid organs.@(((:tag . "JJ") (:stem . "clinical") (:form . "Clinical") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deterioration") (:form . "deterioration")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 48) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 136)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "burden") (:form . "burden") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s988.2) (:did . :|9075924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009234@unknown@formal@none@1@S@T cell activation and ensuing cellular gene activation can be critical for HIV-1 replication.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "ensue") (:form . "ensuing") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x988.3.1) (:span 55 58)))\n (:hscopes ((:id . :x988.3.1) (:span 55 92)))\n (:identifiers (:sid . :s988.3) (:did . :|9075924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009235@unknown@formal@none@1@S@The hypothesis that the nuclear factor of activated T cells (NF-AT) may influence HIV-1 replication is therefore compelling given the tight correlation of HIV-1 transcriptional induction to T cell activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 99)\n  (:start . 88) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "JJ") (:stem . "compelling") (:form . "compelling") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 151)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 160)\n  (:start . 155) (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 176) (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 186)\n  (:start . 177) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 191) (:start . 190)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 207)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x988.4.1) (:span 68 71)) ((:id . :x988.4.2) (:span 4 14)))\n (:hscopes ((:id . :x988.4.1) (:span 68 99)) ((:id . :x988.4.2) (:span 4 99)))\n (:identifiers (:sid . :s988.4) (:did . :|9075924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009236@unknown@formal@none@1@S@We report that certain NF-AT(Rel) family members productively bind the kappaB regulatory elements, synergize with NF-kappaB and Tat in transcriptional activation of HIV-1, and enhance HIV-1 replication in T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "NF-AT(Rel)") (:form . "NF-AT(Rel)") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "RB") (:stem . "productively") (:form . "productively") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 150) (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 189)\n  (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 201)\n  (:start . 190) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 206) (:start . 205)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s988.5) (:did . :|9075924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009237@unknown@formal@none@1@S@These results link regulatory factors critical to T cell commitment directly to HIV-1 replication.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "link") (:form . "link") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s988.6) (:did . :|9075924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009238@unknown@formal@none@1@S@Differentiation of T-helper lymphocytes: selective regulation by members of the STAT family of transcription factors.@(((:tag . "NNP") (:stem . "Differentiation") (:form . "Differentiation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "T-helper") (:form . "T-helper") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 39)\n  (:start . 28) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 40) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s989.1) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009240@unknown@formal@none@1@S@Here we summarize studies which investigate the mechanism by which these cytokines selectively reprogramme gene expression in T-lymphocytes.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "summarize") (:form . "summarize") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . "VBP") (:stem . "reprogramme") (:form . "reprogramme") (:end . 106)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 139) (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s989.3) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009241@unknown@formal@none@1@S@Cytokine stimulation leads to the phosphorylation of specific tyrosine residues within the intracellular domain of the corresponding cytokine receptor.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 26) (:start . 21)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 49) (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 86)\n  (:start . 80) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 104) (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 111)\n  (:start . 105) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 132)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 141)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 150)\n  (:start . 142) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s989.4) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009242@unknown@formal@none@1@S@These phosphotyrosines serve as docking sites for latent, cytoplasmic transcription factors known as signal transducers and activators of transcription (Stat) proteins.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "phosphotyrosine") (:form . "phosphotyrosines")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 119)\n  (:start . 108) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 151) (:start . 138) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s989.5) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009243@unknown@formal@none@1@S@Receptor/Stat interaction is mediated by the src homology 2 (SH2) domain of the corresponding Stat protein.@(((:tag . "NNP") (:stem . "Receptor/Stat") (:form . "Receptor/Stat")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "src") (:form . "src") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 93)\n  (:start . 80) (:id . 57))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s989.6) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009244@unknown@formal@none@1@S@Although Stat binding to the intracellular domain of the cytokine receptor strongly depends on the phosphotyrosine residue, the recruitment of a specific Stat protein is dictated by amino acid residues C-terminal to the phosphotyrosine.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phosphotyrosine") (:form . "phosphotyrosine")\n  (:end . 114) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "dictate") (:form . "dictated") (:end . 178)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 187)\n  (:start . 182) (:id . 70))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 201)\n  (:start . 193) (:id . 72))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 212)\n  (:start . 202) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 215) (:start . 213)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phosphotyrosine") (:form . "phosphotyrosine")\n  (:end . 235) (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s989.7) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009245@unknown@formal@none@1@S@Specific docking sites within individual cytokine receptors have been identified for almost all Stat proteins.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 52))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s989.8) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009246@unknown@formal@none@1@S@The direct coupling between cytokine receptor and transcription factor helps to explain how different cytokines elicit distinct patterns of gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coupling") (:form . "coupling") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "VBZ") (:stem . "help") (:form . "helps") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "VBP") (:stem . "elicit") (:form . "elicit") (:end . 118)\n  (:start . 112) (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s989.9) (:did . :|9078381|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009247@unknown@formal@none@1@S@Regulation of the tissue factor gene in human monocytic cells.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s990.1) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009248@unknown@formal@none@1@S@Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 46))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 46)\n  (:start . 38) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 59)\n  (:start . 50) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 90) (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s990.2) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009250@unknown@formal@none@1@S@Bacterial lipopolysaccharide (LPS) rapidly induces TF gene transcription in monocytes.@(((:tag . "JJ") (:stem . "bacterial") (:form . "Bacterial") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 28) (:start . 10) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s990.4) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009251@unknown@formal@none@1@S@The human TF promoter contains binding sites for the transcription factors AP-1, c-Rel/p65, Egr-1, and Sp1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s990.5) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009252@unknown@formal@none@1@S@NF-kappa B/Rel proteins have been shown to physically interact with both AP-1 and Sp1 proteins.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s990.6) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009253@unknown@formal@none@1@S@In this study, we investigated the role of these transcription factors in uninduced and LPS-induced TF gene expression in human monocytic THP-1 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 137)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s990.7) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009254@unknown@formal@none@1@S@Deletional analysis indicated that five Sp1 sites mediated basal expression in uninduced cells.@(((:tag . "JJ") (:stem . "deletional") (:form . "Deletional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "uninduced") (:form . "uninduced") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x990.8.1) (:span 20 34)))\n (:hscopes ((:id . :x990.8.1) (:span 20 94)))\n (:identifiers (:sid . :s990.8) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009255@unknown@formal@none@1@S@The two AP-1 sites bound c-Fos/c-Jun heterodimers in both unstimulated and LPS-stimulated cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-Fos/c-Jun") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 89) (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s990.9) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009256@unknown@formal@none@1@S@Maximal LPS induction of the TF promoter required the two AP-1 sites and the kappa B site within the LPS response element.@(((:tag . "JJ") (:stem . "maximal") (:form . "Maximal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 121)\n  (:start . 114) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s990.10) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009257@unknown@formal@none@1@S@Disruption of the conserved spacing between the proximal AP-1 site and the kappa B site abolished LPS induction.@(((:tag . "NN") (:stem . "disruption") (:form . "Disruption") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "spacing") (:form . "spacing") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s990.11) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009258@unknown@formal@none@1@S@Replacement of the two AP-1 sites with intrinsically bent DNA partially restored LPS induction, suggesting an additional structural role for the AP-1 sites.@(((:tag . "NN") (:stem . "replacement") (:form . "Replacement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "intrinsically") (:form . "intrinsically")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "bent") (:form . "bent") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x990.12.1) (:span 96 106)))\n (:hscopes ((:id . :x990.12.1) (:span 96 155)))\n (:identifiers (:sid . :s990.12) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009260@unknown@formal@none@1@S@These data indicated that c-Fos/c-Jun, c-Rel/p65, and Sp1 regulate TF gene expression in human monocytic cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-fos/c-jun") (:form . "c-Fos/c-Jun") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-rel/p65") (:form . "c-Rel/p65") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x990.14.1) (:span 11 25)))\n (:hscopes ((:id . :x990.14.1) (:span 11 110)))\n (:identifiers (:sid . :s990.14) (:did . :|9081693|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009261@unknown@formal@none@1@S@Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.@(((:tag . "JJ") (:stem . "physical") (:form . "Physical") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB/NFAT") (:form . "NF-kappaB/NFAT")\n  (:end . 52) (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 93)\n  (:start . 88) (:id . 54))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 146) (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 161)\n  (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s991.1) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009262@unknown@formal@none@1@S@The transcriptional regulatory elements of many inducible T-cell genes contain adjacent or overlapping binding sites for the Ets and NF-kappaB/NFAT families of transcription factors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 102)\n  (:start . 91) (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 116)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NNPS") (:stem . "Ets") (:form . "Ets") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB/NFAT") (:form . "NF-kappaB/NFAT")\n  (:end . 147) (:start . 133) (:id . 61))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 156)\n  (:start . 148) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 173) (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 181)\n  (:start . 174) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s991.2) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009263@unknown@formal@none@1@S@Similar arrays of functionally important NF-kappaB/NFAT and Ets binding sites are present in the transcriptional enhancers of human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2), suggesting that this pattern of nuclear protein binding sites reflects an evolutionarily conserved mechanism for regulating inducible T-cell gene expression that has been co-opted during HIV evolution.@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "array") (:form . "arrays") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB/NFAT") (:form . 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5009264@unknown@formal@none@1@S@Despite these findings, the molecular mechanisms by which Ets and NF-kappaB/NFAT proteins cooperatively regulate inducible T-cell gene expression remained unknown.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB/NFAT") (:form . "NF-kappaB/NFAT")\n  (:end . 80) (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "RB") (:stem . "cooperatively") (:form . "cooperatively")\n  (:end . 103) (:start . 90) (:id . 55))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 129)\n  (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 60))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 154)\n  (:start . 146) (:id . 61))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 162)\n  (:start . 155) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x991.4.1) (:span 155 162)))\n (:hscopes ((:id . :x991.4.1) (:span 24 162)))\n (:identifiers (:sid . :s991.4) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009265@unknown@formal@none@1@S@In the studies described in this report, we demonstrated a physical interaction between multiple Ets and NF-kappaB/NFAT proteins both in vitro and in activated normal human T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 56)\n  (:start . 44) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB/NFAT") (:form . "NF-kappaB/NFAT")\n  (:end . 119) (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 159)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 166)\n  (:start . 160) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s991.5) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009266@unknown@formal@none@1@S@This interaction is mediated by the Ets domain of Ets proteins and the C-terminal region of the Rel homology domains of NF-kappaB/NFAT proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nf-kappab/nfat") (:form . "NF-kappaB/NFAT")\n  (:end . 134) (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s991.6) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009267@unknown@formal@none@1@S@In addition, the Ets-NF-kappaB/NFAT interaction requires the presence of DNA binding sites for both proteins, as it is abolished by the DNA intercalating agents propidium iodide and ethidium bromide and enhanced by the presence of synthetic oligonucleotides containing binding sites for Ets and NF-kappaB proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ets-NF-kappaB/NFAT") (:form . "Ets-NF-kappaB/NFAT")\n  (:end . 35) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . 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"IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "intercalate") (:form . "intercalating")\n  (:end . 153) (:start . 140) (:id . 66))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 160)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "propidium") (:form . "propidium") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "iodide") (:form . 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5009268@unknown@formal@none@1@S@A dominant-negative mutant of NF-kappaB p50 that binds DNA but fails to interact with Ets proteins inhibits the synergistic activation of the HIV-1 and HIV-2 enhancers by NF-kappaB (p50 + p65) and Ets-1, suggesting that physical interaction between Ets and NF-kappaB proteins is required for the transcriptional activity of the HIV-1 and HIV-2 enhancers.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 19) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "WDT") (:stem . 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(:form . ".") (:end . 354) (:start . 353)\n  (:id . 99)))@@@1@58@((:hcues ((:id . :x991.8.1) (:span 204 214)))\n (:ncues ((:id . :x991.8.2) (:span 63 68)))\n (:hscopes ((:id . :x991.8.1) (:span 204 353)))\n (:nscopes ((:id . :x991.8.2) (:span 63 98)))\n (:identifiers (:sid . :s991.8) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009270@unknown@formal@none@1@S@These interactions represent a potential target for the development of novel immunosuppressive and antiviral therapies.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 67)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 94) (:start . 77) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . "NNS") (:stem . "therapy") (:form . "therapies") (:end . 118)\n  (:start . 109) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x991.10.1) (:span 31 40)))\n (:hscopes ((:id . :x991.10.1) (:span 31 118)))\n (:identifiers (:sid . :s991.10) (:did . :|9094628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009271@unknown@formal@none@1@S@Oxidant-regulation of gene expression in the chronically inflamed intestine.@(((:tag . "NN") (:stem . "oxidant-regulation") (:form . "Oxidant-regulation")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "JJ") (:stem . "inflamed") (:form . "inflamed") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "intestine") (:form . "intestine") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s992.1) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009272@unknown@formal@none@1@S@It is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's disease) is associated with enhanced production of leukocyte-derived oxidants.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "become") (:form . "becoming") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "RB") (:stem . "increasingly") (:form . "increasingly") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "gut") (:form . "gut") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 70)\n  (:start . 58) (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "idiopathic") (:form . "idiopathic") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 110)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "bowel") (:form . "bowel") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 125)\n  (:start . 117) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ulcerative") (:form . "ulcerative") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "colitis") (:form . "colitis") (:end . 150)\n  (:start . 143) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Crohn") (:form . "Crohn") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 167)\n  (:start . 160) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 182)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 196)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 207)\n  (:start . 197) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "leukocyte-derived") (:form . "leukocyte-derived")\n  (:end . 228) (:start . 211) (:id . 74))\n ((:tag . "NNS") (:stem . "oxidant") (:form . "oxidants") (:end . 237)\n  (:start . 229) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s992.2) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009273@unknown@formal@none@1@S@Oxidants such as hydrogen peroxide are known to activate certain transcription factors such as nuclear transcription factor kappa beta.@(((:tag . "NNS") (:stem . "oxidant") (:form . "Oxidants") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s992.3) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009274@unknown@formal@none@1@S@Nuclear transcription factor kB (NF-kappa B) is a ubiquitous transcription factor and pleiotropic regulator of numerous genes involved in the immune and inflammatory responses.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 44))\n ((:tag . "NNP") (:stem . "kB") (:form . "kB") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 165)\n  (:start . 153) (:id . 66))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 175)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s992.4) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009275@unknown@formal@none@1@S@This transcription factor is activated via the selective phosphorylation, ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules (e.g. ICAM-1, VCAM-1), cytokines (TNF, IL-1, IL-6) and enzymes (iNOS).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"adhesion") (:end . 258)\n  (:start . 250) (:id . 78))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 268)\n  (:start . 259) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 270) (:start . 269)\n  (:id . 80))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 274) (:start . 270)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 281)\n  (:start . 275) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 282) (:start . 281)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 289)\n  (:start . 283) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 290) (:start . 289)\n  (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 291) (:start . 290)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 301)\n  (:start . 292) (:id . 87))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 303) (:start . 302)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 306) (:start . 303)\n  (:id . 89))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 307) (:start . 306)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 312) (:start . 308)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 313) (:start . 312)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 318) (:start . 314)\n  (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 319) (:start . 318)\n  (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 323) (:start . 320)\n  (:id . 95))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 331)\n  (:start . 324) (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 333) (:start . 332)\n  (:id . 97))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 337) (:start . 333)\n  (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 338) (:start . 337)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 339) (:start . 338)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s992.5) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009276@unknown@formal@none@1@S@The proteolytic degradation of the post-translationally modified I-kappa B is known to be mediated by the 26S proteasome complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "post-translationally")\n  (:form . "post-translationally") (:end . 55) (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "NNP") (:stem . "I-kappa") (:form . "I-kappa") (:end . 72)\n  (:start . 65) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "26s") (:form . "26S") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s992.6) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009277@unknown@formal@none@1@S@Based upon work from our laboratory, we propose that inhibition of NF-kappa B activation produces significant anti inflammatory activity which may be mediated by the inhibition of transcription of certain pro-inflammatory mediators and adhesion molecules.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 176)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 193) (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 204)\n  (:start . 197) (:id . 72))\n ((:tag . "JJ") (:stem . "pro-inflammatory") (:form . "pro-inflammatory")\n  (:end . 221) (:start . 205) (:id . 73))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 231)\n  (:start . 222) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 75))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 244)\n  (:start . 236) (:id . 76))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 254)\n  (:start . 245) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x992.7.1) (:span 143 146))\n  ((:id . :x992.7.2) (:span 40 47)))\n (:hscopes ((:id . :x992.7.1) (:span 137 254))\n  ((:id . :x992.7.2) (:span 40 254)))\n (:identifiers (:sid . :s992.7) (:did . :|9095577|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009278@unknown@formal@none@1@S@Expression of LAZ3/BCL6 in follicular center (FC) B cells of reactive lymph nodes and FC-derived non-Hodgkin lymphomas.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "laz3/bcl6") (:form . "LAZ3/BCL6") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "follicular") (:form . "follicular") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FC") (:form . "FC") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fc-derived") (:form . "FC-derived") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "JJ") (:stem . "non-hodgkin") (:form . "non-Hodgkin") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s993.1) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009280@unknown@formal@none@1@S@Therefore we studied the expression pattern of LAZ3/BCL6 by in situ hybridization with synthetic oligonucleotide probes in frozen tissue sections from five reactive lymph nodes and 38 B cell and non-B NHL.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LAZ3/BCL6") (:form . "LAZ3/BCL6") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 112) (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "probe") (:form . "probes") (:end . 119)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "frozen") (:form . "frozen") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 136)\n  (:start . 130) (:id . 60))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 164)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 176)\n  (:start . 171) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 67))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 200)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "nhl") (:form . "NHL") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s993.3) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009281@unknown@formal@none@1@S@In addition, we investigated the expression of LAZ3/BCL6 by Northern blot analysis on multiple human tissues.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 28)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LAZ3/BCL6") (:form . "LAZ3/BCL6") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s993.4) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009282@unknown@formal@none@1@S@The LAZ3/BCL6 transcript was found in a variety of tissues, including skeletal muscle, peripheral blood leukocytes, and weakly in normal lymph nodes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LAZ3/BCL6") (:form . "LAZ3/BCL6") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "skeletal") (:form . "skeletal") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s993.5) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009283@unknown@formal@none@1@S@In the tumor samples, expression of LAZ3/BCL6 was observed in 68% of all B cell NHL and none of the non-B lymphomas.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LAZ3/BCL6") (:form . "LAZ3/BCL6") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "CD") (:stem . "68") (:form . "68") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nhl") (:form . "NHL") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 60))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 92) (:start . 88)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 105)\n  (:start . 100) (:id . 64))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 115)\n  (:start . 106) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x993.6.1) (:span 88 92)))\n (:nscopes ((:id . :x993.6.1) (:span 88 115)))\n (:identifiers (:sid . :s993.6) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009284@unknown@formal@none@1@S@All cases of follicular, mixed small and large cell lymphomas showed LAZ3/BCL6 expression confined to the neoplastic follicles.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "follicular") (:form . "follicular") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mixed") (:form . "mixed") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphoma") (:form . "lymphomas") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 68) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "laz3/bcl6") (:form . "LAZ3/BCL6") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "VBN") (:stem . "confine") (:form . "confined") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "neoplastic") (:form . "neoplastic") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "follicle") (:form . "follicles") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s993.7) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009285@unknown@formal@none@1@S@A follicular expression pattern was also found in all non-malignant reactive lymph nodes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "follicular") (:form . "follicular") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "non-malignant") (:form . "non-malignant")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s993.8) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009286@unknown@formal@none@1@S@Hence, the expression of LAZ3/BCL6 does not correlate to malignancy, but reflects the origin of B cells from the germinal centers.@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LAZ3/BCL6") (:form . "LAZ3/BCL6") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "correlate") (:form . "correlate") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "malignancy") (:form . "malignancy") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "NNS") (:stem . "center") (:form . "centers") (:end . 129)\n  (:start . 122) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x993.9.1) (:span 40 43)))\n (:nscopes ((:id . :x993.9.1) (:span 40 67)))\n (:identifiers (:sid . :s993.9) (:did . :|9096701|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009287@unknown@formal@none@1@S@Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "relA(p65)") (:form . "relA(p65)") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 84) (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 135)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s994.1) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009288@unknown@formal@none@1@S@We evaluated the expression and DNA binding activity of nuclear factor (NF)-kappa B subunits in human peripheral blood monocytes and in monocyte-derived macrophages (MDMs).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 152) (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 164)\n  (:start . 153) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MDM") (:form . "MDMs") (:end . 170) (:start . 166)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s994.2) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009290@unknown@formal@none@1@S@An additional complex composed of p50/RelA(p65) heterodimers appeared only in nuclear extracts from 7-day MDMs.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "p50/RelA(p65)") (:form . "p50/RelA(p65)")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 60)\n  (:start . 48) (:id . 48))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "7-day") (:form . "7-day") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "mdm") (:form . "MDMs") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s994.4) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009291@unknown@formal@none@1@S@Immunoblot analysis showed that the p50 subunit was constitutively expressed in monocytes and MDMs.@(((:tag . "NNP") (:stem . "Immunoblot") (:form . "Immunoblot") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 26) (:start . 20)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 66) (:start . 52) (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mdm") (:form . "MDMs") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s994.5) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009292@unknown@formal@none@1@S@In contrast, the RelA(p65) subunit was barely detectable in monocytes, but its level increased markedly in MDMs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "barely") (:form . "barely") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MDM") (:form . "MDMs") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s994.6) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009293@unknown@formal@none@1@S@Analysis of RelA(p65) mRNA revealed that the stability of RelA(p65) mRNA was significantly higher in MDMs, compared with monocytes.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RelA(p65)") (:form . "RelA(p65)") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 97) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MDM") (:form . "MDMs") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s994.7) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009294@unknown@formal@none@1@S@In MDMs, an upregulation of I kappa B alpha synthesis as well as the appearance of a novel M(r) 40,000 form of I kappa B alpha were also observed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MDM") (:form . "MDMs") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 24)\n  (:start . 12) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 79)\n  (:start . 69) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "M(r)") (:form . "M(r)") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "CD") (:stem . "40,000") (:form . "40,000") (:end . 102)\n  (:start . 96) (:id . 62))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 107) (:start . 103)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 64))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 112) (:start . 111)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 118)\n  (:start . 113) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 126)\n  (:start . 121) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 131) (:start . 127)\n  (:id . 69))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 136) (:start . 132)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 145)\n  (:start . 137) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s994.8) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009295@unknown@formal@none@1@S@These results suggest that macrophage differentiation results in the expression of active p50/RelA(p65) heterodimers with the capacity to activate target gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 53) (:start . 38) (:id . 47))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "p50/RelA(p65)") (:form . "p50/RelA(p65)")\n  (:end . 103) (:start . 90) (:id . 54))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 116)\n  (:start . 104) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 57))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 134)\n  (:start . 126) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 146)\n  (:start . 138) (:id . 60))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 153)\n  (:start . 147) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 158) (:start . 154)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x994.9.1) (:span 14 21)))\n (:hscopes ((:id . :x994.9.1) (:span 14 169)))\n (:identifiers (:sid . :s994.9) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009296@unknown@formal@none@1@S@The parallel induction of I kappa B alpha synthesis may allow for the continuous presence of a cytoplasmic reservoir of p50/RelA(p65) complexes that are readily available for inducer-mediated stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "parallel") (:form . "parallel") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "continuous") (:form . "continuous") (:end . 80)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "reservoir") (:form . "reservoir") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "p50/RelA(p65)") (:form . "p50/RelA(p65)")\n  (:end . 133) (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 170)\n  (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inducer-mediated") (:form . "inducer-mediated")\n  (:end . 191) (:start . 175) (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 203)\n  (:start . 192) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x994.10.1) (:span 52 55)))\n (:hscopes ((:id . :x994.10.1) (:span 52 203)))\n (:identifiers (:sid . :s994.10) (:did . :|9101089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009297@unknown@formal@none@1@S@Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-5") (:form . "interleukin-5")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 69) (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 82)\n  (:start . 76) (:id . 51))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 104)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 123) (:start . 108) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s995.1) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009298@unknown@formal@none@1@S@Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis.@(((:tag . "NNP") (:stem . "Glucocorticoid") (:form . "Glucocorticoids")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 62)\n  (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "eosinophilia") (:form . "eosinophilia") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "dermatitis") (:form . "dermatitis") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s995.2) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009300@unknown@formal@none@1@S@To delineate the regulatory mechanisms of human IL-5 synthesis, we established allergen-specific CD4+ T-cell clones from asthmatic patients.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 96) (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 130)\n  (:start . 121) (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s995.4) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009301@unknown@formal@none@1@S@GC efficiently suppressed IL-5 synthesis of T-cell clones activated via either T-cell receptor (TCR) or IL-2 receptor (IL-2R).@(((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s995.5) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009302@unknown@formal@none@1@S@Induction of IL-5 mRNA upon TCR and IL-2R stimulation was totally inhibited by dexamethasone.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s995.6) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009303@unknown@formal@none@1@S@Human IL-5 promoter/enhancer-luciferase gene construct transfected to T-cell clones was transcribed on either TCR or IL-2R stimulation and was clearly downregulated by dexamethasone, indicating that the approximately 500-bp human IL-5 gene segment located 5' upstream of the coding region contains activation-inducible enhancer elements responsible for the regulation by GC.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter/enhancer-luciferase")\n  (:form . "promoter/enhancer-luciferase") (:end . 39) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 45))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 54)\n  (:start . 45) (:id . 46))\n ((:tag . "VBN") (:stem . "transfecte") (:form . 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"'") (:end . 258) (:start . 257)\n  (:id . 77))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 267)\n  (:start . 259) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 270) (:start . 268)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 274) (:start . 271)\n  (:id . 80))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 281)\n  (:start . 275) (:id . 81))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 288)\n  (:start . 282) (:id . 82))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 297)\n  (:start . 289) (:id . 83))\n ((:tag . "JJ") (:stem . "activation-inducible")\n  (:form . "activation-inducible") (:end . 318) (:start . 298) (:id . 84))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 327)\n  (:start . 319) (:id . 85))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 336)\n  (:start . 328) (:id . 86))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 348)\n  (:start . 337) (:id . 87))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 352) (:start . 349)\n  (:id . 88))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 356) (:start . 353)\n  (:id . 89))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 367)\n  (:start . 357) (:id . 90))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 370) (:start . 368)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 373) (:start . 371)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 374) (:start . 373)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x995.7.1) (:span 183 198)))\n (:hscopes ((:id . :x995.7.1) (:span 183 373)))\n (:identifiers (:sid . :s995.7) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009304@unknown@formal@none@1@S@Electrophoretic mobility shift assay analysis suggested that AP-1 and NF-kappaB are among the possible targets of GC actions on TCR-stimulated T cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tcr-stimulated") (:form . "TCR-stimulated")\n  (:end . 142) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x995.8.1) (:span 94 102)) ((:id . :x995.8.2) (:span 46 55)))\n (:hscopes ((:id . :x995.8.1) (:span 94 150))\n  ((:id . :x995.8.2) (:span 46 150)))\n (:identifiers (:sid . :s995.8) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009305@unknown@formal@none@1@S@NF-AT and NF-kappaB were not significantly induced by IL-2 stimulation.@(((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s995.9) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009306@unknown@formal@none@1@S@Our results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 137)\n  (:start . 126) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "underscore") (:form . "underscore") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 162)\n  (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 185)\n  (:start . 176) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 197)\n  (:start . 189) (:id . 75))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 206)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 210) (:start . 207)\n  (:id . 77))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 222)\n  (:start . 211) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 225) (:start . 223)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 232)\n  (:start . 226) (:id . 80))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 237) (:start . 233)\n  (:id . 81))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 247)\n  (:start . 238) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s995.10) (:did . :|9108409|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009307@unknown@formal@none@1@S@Involvement of an SAF-like transcription factor in the activation of serum amyloid A gene in monocyte/macrophage cells by lipopolysaccharide.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "saf-like") (:form . "SAF-like") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "amyloid") (:form . "amyloid") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 112) (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 140) (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s996.1) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009308@unknown@formal@none@1@S@Serum amyloid A (SAA) has been linked to atherosclerosis because of its ability to remodel high-density lipoprotein by the depletion of apolipoprotein A1, its ability to bind cholesterol, and its presence in the atherosclerotic plaques of coronary and carotid arteries.@(((:tag . "NNP") (:stem . "Serum") (:form . "Serum") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "amyloid") (:form . "amyloid") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SAA") (:form . "SAA") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 30) (:start . 26)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 37) (:start . 31)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 56) (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "VB") (:stem . "remodel") (:form . "remodel") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "high-density") (:form . "high-density") (:end . 103)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 115)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "apolipoprotein") (:form . "apolipoprotein")\n  (:end . 150) (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "a1") (:form . "A1") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cholesterol") (:form . "cholesterol") (:end . 186)\n  (:start . 175) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 204)\n  (:start . 196) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 227) (:start . 212) (:id . 79))\n ((:tag . "NNS") (:stem . "plaque") (:form . "plaques") (:end . 235)\n  (:start . 228) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "coronary") (:form . "coronary") (:end . 247)\n  (:start . 239) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 251) (:start . 248)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "carotid") (:form . "carotid") (:end . 259)\n  (:start . 252) (:id . 84))\n ((:tag . "NNS") (:stem . "artery") (:form . "arteries") (:end . 268)\n  (:start . 260) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s996.2) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009310@unknown@formal@none@1@S@We and others have shown that SAA gene is induced in monocyte/macrophage cells by lipopolysaccharide (LPS).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SAA") (:form . "SAA") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 72) (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 100) (:start . 82) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s996.4) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009311@unknown@formal@none@1@S@By promoter function analysis, we show that the SAA promoter sequence between -280 and -226 can confer LPS responsiveness.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SAA") (:form . "SAA") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "CD") (:stem . "-280") (:form . "-280") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-226") (:form . "-226") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VB") (:stem . "confer") (:form . "confer") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 121) (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s996.5) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009312@unknown@formal@none@1@S@Gel electrophoretic mobility shift assay detected an induced DNA-binding activity in these cells in response to LPS.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 72)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s996.6) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009313@unknown@formal@none@1@S@Characterization of the DNA-binding protein by UV cross-linking, Southwestern blot, and antibody ablation/supershift assays revealed that it is similar to a recently reported nuclear factor designated SAF.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "UV") (:form . "UV") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Southwestern") (:form . "Southwestern") (:end . 77)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "ablation/supershift")\n  (:form . "ablation/supershift") (:end . 116) (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 123)\n  (:start . 117) (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 174)\n  (:start . 166) (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 182)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 189)\n  (:start . 183) (:id . 68))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 200)\n  (:start . 190) (:id . 69))\n ((:tag . "NNP") (:stem . "SAF") (:form . "SAF") (:end . 204) (:start . 201)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s996.7) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009314@unknown@formal@none@1@S@These results demonstrated that LPS-mediated SAA gene induction in monocyte/macrophage cells is primarily due to the induction of SAF activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "SAA") (:form . "SAA") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "monocyte/macrophage")\n  (:form . "monocyte/macrophage") (:end . 86) (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 105)\n  (:start . 96) (:id . 54))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 109) (:start . 106)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SAF") (:form . "SAF") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s996.8) (:did . :|9109677|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009315@unknown@formal@none@1@S@Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.@(((:tag . "JJ") (:stem . "oncogenic") (:form . "Oncogenic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "notch1") (:form . "NOTCH1") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RBP-Jkappa") (:form . "RBP-Jkappa") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 104)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "VBP") (:stem . "retain") (:form . "retain") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 133)\n  (:start . 126) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RBP-Jkappa") (:form . "RBP-Jkappa") (:end . 162)\n  (:start . 152) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 175)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 189) (:start . 176) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x997.1.1) (:span 26 33)))\n (:nscopes ((:id . :x997.1.1) (:span 26 114)))\n (:identifiers (:sid . :s997.1) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009316@unknown@formal@none@1@S@Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.@(((:tag . "JJ") (:stem . "truncated") (:form . "Truncated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "notch1") (:form . "NOTCH1") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBN") (:stem . "engineer") (:form . "engineered") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "VB") (:stem . "resemble") (:form . "resemble") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NOTCH1") (:form . "NOTCH1") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "leukemia/lymphoma") (:form . "leukemia/lymphoma")\n  (:end . 155) (:start . 138) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 175)\n  (:start . 164) (:id . 68))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "t-all") (:form . "T-ALL") (:end . 188)\n  (:start . 183) (:id . 70))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 203)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 215) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 222)\n  (:start . 216) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 225) (:start . 223)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 230)\n  (:start . 226) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s997.2) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009317@unknown@formal@none@1@S@Unlike full-sized NOTCH1, two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN) were found to activate transcription in cultured cells, presumably through RBP-Jkappa response elements within DNA.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "full-sized") (:form . "full-sized") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "notch1") (:form . "NOTCH1") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "truncated") (:form . 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"DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DeltaE") (:form . "DeltaE") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 147)\n  (:start . 137) (:id . 66))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 173) (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 180)\n  (:start . 174) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 182) (:start . 181)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "ICN") (:form . "ICN") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 191) (:start . 187)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 197)\n  (:start . 192) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 209)\n  (:start . 201) (:id . 78))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 223) (:start . 210) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 235)\n  (:start . 227) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 241)\n  (:start . 236) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 242) (:start . 241)\n  (:id . 83))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 253)\n  (:start . 243) (:id . 84))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 261)\n  (:start . 254) (:id . 85))\n ((:tag . "NNP") (:stem . "RBP-Jkappa") (:form . "RBP-Jkappa") (:end . 272)\n  (:start . 262) (:id . 86))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 281)\n  (:start . 273) (:id . 87))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 290)\n  (:start . 282) (:id . 88))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 297)\n  (:start . 291) (:id . 89))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 301) (:start . 298)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x997.3.1) (:span 243 253)))\n (:ncues ((:id . :x997.3.2) (:span 73 80)))\n (:hscopes ((:id . :x997.3.1) (:span 243 301)))\n (:nscopes ((:id . :x997.3.2) (:span 73 133)))\n (:identifiers (:sid . :s997.3) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009318@unknown@formal@none@1@S@Both truncated forms also bound to the transcription factor RBP-Jkappa in extracts prepared from human and murine T-ALL cell lines.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "truncated") (:form . "truncated") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NNP") (:stem . "RBP-Jkappa") (:form . "RBP-Jkappa") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "t-all") (:form . "T-ALL") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s997.4) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009320@unknown@formal@none@1@S@Unexpectedly, a second, stronger RBP-Jkappa-binding site, which lies within the intracellular domain close to the transmembrane region and significantly augments association with RBP-Jkappa, was not needed for oncogenesis or for transcriptional activation.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "rbp-jkappa-binding") (:form . "RBP-Jkappa-binding")\n  (:end . 51) (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 127) (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 152) (:start . 139) (:id . 63))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 161)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 173)\n  (:start . 162) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 178) (:start . 174)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RBP-Jkappa") (:form . "RBP-Jkappa") (:end . 189)\n  (:start . 179) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 194) (:start . 191)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 198) (:start . 195)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 205)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 209) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 221)\n  (:start . 210) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 224) (:start . 222)\n  (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 228) (:start . 225)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 244) (:start . 229) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 255)\n  (:start . 245) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x997.6.1) (:span 195 198)))\n (:nscopes ((:id . :x997.6.1) (:span 14 255)))\n (:identifiers (:sid . :s997.6) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009321@unknown@formal@none@1@S@While ICN appeared primarily in the nucleus, DeltaE localized to cytoplasmic and nuclear membranes, suggesting that intranuclear localization is not essential for oncogenesis or transcriptional activation.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ICN") (:form . "ICN") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DeltaE") (:form . "DeltaE") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 76)\n  (:start . 65) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "membrane") (:form . "membranes") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intranuclear") (:form . "intranuclear") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 141)\n  (:start . 129) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 174)\n  (:start . 163) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 177) (:start . 175)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 193) (:start . 178) (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 204)\n  (:start . 194) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x997.7.2) (:span 100 110)))\n (:ncues ((:id . :x997.7.1) (:span 145 148)))\n (:hscopes ((:id . :x997.7.2) (:span 100 204)))\n (:nscopes ((:id . :x997.7.1) (:span 145 204)))\n (:identifiers (:sid . :s997.7) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009322@unknown@formal@none@1@S@In support of this interpretation, mutation of putative nuclear localization sequences decreased nuclear localization and increased transcriptional activation by membrane-bound DeltaE.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 33) (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 76)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 117)\n  (:start . 105) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 131)\n  (:start . 122) (:id . 58))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 147) (:start . 132) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "membrane-bound") (:form . "membrane-bound")\n  (:end . 176) (:start . 162) (:id . 62))\n ((:tag . "NN") (:stem . "deltae") (:form . "DeltaE") (:end . 183)\n  (:start . 177) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s997.8) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009323@unknown@formal@none@1@S@Transcriptional activation by this mutant form of membrane-bound DeltaE was approximately equivalent to that produced by intranuclear ICN.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "membrane-bound") (:form . "membrane-bound")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "deltae") (:form . "DeltaE") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 89) (:start . 76) (:id . 52))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 100)\n  (:start . 90) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intranuclear") (:form . "intranuclear") (:end . 133)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "icn") (:form . "ICN") (:end . 137) (:start . 134)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s997.9) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009324@unknown@formal@none@1@S@These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "notch1") (:form . "NOTCH1") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 74) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 103)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 118)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RBP-Jkappa") (:form . "RBP-Jkappa") (:end . 134)\n  (:start . 124) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 60))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 152)\n  (:start . 147) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s997.10) (:did . :|9111040|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009325@unknown@formal@none@1@S@Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 25)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 42) (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 60) (:start . 46) (:id . 47))\n ((:tag . "JJ") (:stem . "monocyte-like") (:form . "monocyte-like")\n  (:end . 74) (:start . 61) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 80) (:start . 76)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 108) (:start . 104)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NNP") (:stem . "C/EBP-beta") (:form . "C/EBP-beta") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s998.1) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009326@unknown@formal@none@1@S@In this report, we demonstrate that the AP-1 site and a distal promoter element regulate transcriptional induction of collagenase-1 during monocytic differentiation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 62)\n  (:start . 56) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 104) (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 131) (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 148)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 164) (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s998.2) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009327@unknown@formal@none@1@S@Chloramphenicol acetyltransferase expression constructs containing regions of the human collagenase-1 promoter were stably or transiently transfected into U937 cells, and reporter activity was assessed at various times after the onset of phorbol 12-myristate 13-acetate (PMA)-mediated differentiation.@(((:tag . "NNP") (:stem . "Chloramphenicol") (:form . "Chloramphenicol")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 33) (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 44))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 55)\n  (:start . 45) (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 66)\n  (:start . 56) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 74)\n  (:start . 67) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 50))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 101) (:start . 88) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 110)\n  (:start . 102) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 115) (:start . 111)\n  (:id . 53))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 122)\n  (:start . 116) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 55))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 137)\n  (:start . 126) (:id . 56))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 149)\n  (:start . 138) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 154) (:start . 150)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 159) (:start . 155)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 62))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 179)\n  (:start . 171) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 188)\n  (:start . 180) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 201)\n  (:start . 193) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 204) (:start . 202)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 212)\n  (:start . 205) (:id . 68))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 218)\n  (:start . 213) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 224)\n  (:start . 219) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 71))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 234)\n  (:start . 229) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 73))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 245)\n  (:start . 238) (:id . 74))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 258)\n  (:start . 246) (:id . 75))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 269)\n  (:start . 259) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 271) (:start . 270)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "PMA)-mediated") (:form . "PMA)-mediated")\n  (:end . 284) (:start . 271) (:id . 78))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 300) (:start . 285) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s998.3) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009328@unknown@formal@none@1@S@Rapid and strong induction of promoter activity was lost in constructs with a mutant AP-1 element; however, at 16-96 h post-PMA, the mutant collagenase-1 promoter displayed AP-1 independent PMA-mediated transactivation.@(((:tag . "JJ") (:stem . "rapid") (:form . "Rapid") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "CD") (:stem . "16-96") (:form . "16-96") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "post-PMA") (:form . "post-PMA") (:end . 127)\n  (:start . 119) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 139)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 153) (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 172)\n  (:start . 163) (:id . 70))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 189)\n  (:start . 178) (:id . 72))\n ((:tag . "JJ") (:stem . "pma-mediated") (:form . "PMA-mediated") (:end . 202)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 218) (:start . 203) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s998.4) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009330@unknown@formal@none@1@S@Western and supershift analyses indicated that functional Jun and Fos proteins were present in nuclear extracts of PMA-differentiated U937 cells.@(((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pma-differentiated") (:form . "PMA-differentiated")\n  (:end . 133) (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x998.6.1) (:span 32 46)))\n (:hscopes ((:id . :x998.6.1) (:span 32 144)))\n (:identifiers (:sid . :s998.6) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009331@unknown@formal@none@1@S@Promoter deletion constructs demonstrated the potential role of distal promoter sequences in regulating collagenase-1 transcription.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 117) (:start . 104) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x998.7.1) (:span 46 55)))\n (:hscopes ((:id . :x998.7.1) (:span 46 131)))\n (:identifiers (:sid . :s998.7) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009332@unknown@formal@none@1@S@In particular, Western, supershift, and promoter deletion analyses suggested a role for CCAAT/enhancer-binding protein-beta (C/EBP-beta) binding site between -2010 and -1954 in regulating transcription of collagenase-1 in monocytic cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ccaat/enhancer-binding")\n  (:form . "CCAAT/enhancer-binding") (:end . 110) (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "protein-beta") (:form . "protein-beta") (:end . 123)\n  (:start . 111) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "C/EBP-beta") (:form . "C/EBP-beta") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "CD") (:stem . "-2010") (:form . "-2010") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-1954") (:form . "-1954") (:end . 173)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 201) (:start . 188) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 218) (:start . 205) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 231)\n  (:start . 222) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 237)\n  (:start . 232) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x998.8.1) (:span 67 76)))\n (:hscopes ((:id . :x998.8.1) (:span 67 237)))\n (:identifiers (:sid . :s998.8) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009333@unknown@formal@none@1@S@Our findings suggest that distinct regulatory elements, acting somewhat independently of each other, control expression of collagenase-1.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 62) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "somewhat") (:form . "somewhat") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "control") (:form . "control") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x998.9.1) (:span 13 20)))\n (:hscopes ((:id . :x998.9.1) (:span 13 136)))\n (:identifiers (:sid . :s998.9) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009334@unknown@formal@none@1@S@In addition, our data suggests that the rapid PMA-mediated induction of collagenase-1 transcription is controlled by a mechanism distinct from that regulating the sustained expression of this proteinase in activated macrophages.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pma-mediated") (:form . "PMA-mediated") (:end . 58)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "collagenase-1") (:form . "collagenase-1")\n  (:end . 85) (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 99) (:start . 86) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 113)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 158)\n  (:start . 148) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 191) (:start . 187)\n  (:id . 69))\n ((:tag . "NN") (:stem . "proteinase") (:form . "proteinase") (:end . 202)\n  (:start . 192) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 215)\n  (:start . 206) (:id . 72))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 227)\n  (:start . 216) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x998.10.1) (:span 22 30)))\n (:hscopes ((:id . :x998.10.1) (:span 22 227)))\n (:identifiers (:sid . :s998.10) (:did . :|9115242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009335@unknown@formal@none@1@S@A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s999.1) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009336@unknown@formal@none@1@S@Recent studies have revealed that interactions between transcription factors play an important role in regulation of gene expression in eukaryotic cells.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 68) (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 113)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 132)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 146)\n  (:start . 136) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s999.2) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009337@unknown@formal@none@1@S@To isolate cDNA clones that dominantly inhibit the DNA-binding activity of Oct-2, chosen as a representative factor, we have developed a novel screening system.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "dominantly") (:form . "dominantly") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "representative") (:form . "representative")\n  (:end . 108) (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "screening") (:form . "screening") (:end . 152)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s999.3) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009338@unknown@formal@none@1@S@This employs an Escherichia coli tester strain carrying a modified lac operon as a reporter gene, with the lac operator sequence replaced by an octamer sequence.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "employ") (:form . "employs") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "escherichia") (:form . "Escherichia") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tester") (:form . "tester") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "lac") (:form . "lac") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "operon") (:form . "operon") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lac") (:form . "lac") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "operator") (:form . "operator") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s999.4) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009340@unknown@formal@none@1@S@Introduction of a cDNA expression library prepared from a human T-cell line into the Oct-2-harboring tester strain allowed selection of three Lac+clones out of 1 x 10(5) transformants.@(((:tag . "NN") (:stem . "introduction") (:form . "Introduction") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "library") (:form . "library") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "oct-2-harboring") (:form . "Oct-2-harboring")\n  (:end . 100) (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "tester") (:form . "tester") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "lac+clone") (:form . "Lac+clones") (:end . 152)\n  (:start . 142) (:id . 63))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "CD") (:stem . "10(5)") (:form . "10(5)") (:end . 169)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "transformant") (:form . "transformants")\n  (:end . 183) (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s999.6) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009341@unknown@formal@none@1@S@One of them, hT86, encoding a putative zinc finger protein was found to derepress beta-galactosidase activity in the Oct-2-harboring tester strain at the transcriptional level.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ht86") (:form . "hT86") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 27)\n  (:start . 19) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 38)\n  (:start . 30) (:id . 50))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "VB") (:stem . "derepress") (:form . "derepress") (:end . 81)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "beta-galactosidase") (:form . "beta-galactosidase")\n  (:end . 100) (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "oct-2-harboring") (:form . "Oct-2-harboring")\n  (:end . 132) (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "tester") (:form . "tester") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 146)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 169) (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 175)\n  (:start . 170) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s999.7) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009342@unknown@formal@none@1@S@In gel mobility shift assays, hT86 attenuated the intensity of the retarded band composed of the octamer probe and Oct-2, suggesting a dominant negative effect on the DNA-binding activity of Oct-2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ht86") (:form . "hT86") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "intensity") (:form . "intensity") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "retard") (:form . "retarded") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 143)\n  (:start . 135) (:id . 66))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 187)\n  (:start . 179) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 196)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x999.8.1) (:span 122 132)))\n (:hscopes ((:id . :x999.8.1) (:span 122 196)))\n (:identifiers (:sid . :s999.8) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009343@unknown@formal@none@1@S@The strategy described here provides a new approach for studying protein-protein interactions that govern the complex regulation of gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 80) (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 93)\n  (:start . 81) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "govern") (:form . "govern") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 128)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s999.9) (:did . :|9115366|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009344@unknown@formal@none@1@S@A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphoinositide") (:form . "phosphoinositide")\n  (:end . 36) (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1000.1) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009345@unknown@formal@none@1@S@BACKGROUND: A delicate balance between positive and negative regulatory mechanisms during T-cell activation determines the specificity and magnitude of an immune response.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "delicate") (:form . "delicate") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 55))\n ((:tag . "VBZ") (:stem . "determine") (:form . "determines") (:end . 118)\n  (:start . 108) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 134)\n  (:start . 123) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 59))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 148)\n  (:start . 139) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 161)\n  (:start . 155) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 170)\n  (:start . 162) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1000.2) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009346@unknown@formal@none@1@S@Phosphoinositide 3-kinase (PI 3-kinase) is activated by a diverse set of receptors that determine T-cell function, including the T-cell antigen receptor (TCR), the costimulatory receptor CD28, and negative regulators of T-cell activation such as CTLA-4.@(((:tag . "NNP") (:stem . "Phosphoinositide") (:form . "Phosphoinositide")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 25)\n  (:start . 17) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "determine") (:form . "determine") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 177) (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 186)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 191) (:start . 187)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 205)\n  (:start . 197) (:id . 76))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 216)\n  (:start . 206) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 78))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 226)\n  (:start . 220) (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 237)\n  (:start . 227) (:id . 80))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 242) (:start . 238)\n  (:id . 81))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 245) (:start . 243)\n  (:id . 82))\n ((:tag . "NN") (:stem . "ctla-4") (:form . "CTLA-4") (:end . 252)\n  (:start . 246) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1000.3) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009347@unknown@formal@none@1@S@PI 3-kinase is also regulated by the haematopoietic cytokines that determine T-cell differentiation and lymphocyte proliferation.@(((:tag . "NN") (:stem . "pi") (:form . "PI") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "haematopoietic") (:form . "haematopoietic")\n  (:end . 51) (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "determine") (:form . "determine") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 99) (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 128) (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1000.4) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009348@unknown@formal@none@1@S@PI 3-kinase can thus dynamically influence the outcome of the immune reactions at various stages.@(((:tag . "NN") (:stem . "pi") (:form . "PI") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "dynamically") (:form . "dynamically") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "outcome") (:form . "outcome") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1000.5) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009350@unknown@formal@none@1@S@RESULTS: Certain aspects of TCR responses such as the induction of transcriptional activity of AP1 and serum response factor were not affected by expression of the mutant forms of PI 3-kinase.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "certain") (:form . "Certain") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 82) (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 191)\n  (:start . 183) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1000.7.1) (:span 130 133)))\n (:nscopes ((:id . :x1000.7.1) (:span 9 191)))\n (:identifiers (:sid . :s1000.7) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009351@unknown@formal@none@1@S@We found, however, that PI 3-kinase profoundly influenced the transactivation capacity of 'nuclear factor of activated T cells' (NF-AT) elicited by the TCR: expression of an activated form of PI 3-kinase inhibited TCR-mediated NF-AT responses, whereas expression of a dominant negative mutant of PI 3-kinase potently enhanced TCR-controlled NF-AT induction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PI") (:form . 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5009352@unknown@formal@none@1@S@These effects of PI 3-kinase were not mediated by previously identified PI 3-kinase effectors, such as protein kinase B, a positive regulator of PI 3-kinase, or the GTPase Rac, and are therefore likely to involve a novel, as yet unknown, effector molecule.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . 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5009353@unknown@formal@none@1@S@CONCLUSIONS: Our results establish that PI 3-kinase can both positively and negatively regulate T-cell function, and uncover a previously unrecognized function for PI 3-kinase in T cells as a selective negative regulator of TCR-signalling events and therefore as a determinant of T-cell homeostasis.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 102)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "uncover") (:form . "uncover") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "JJ") (:stem . "unrecognized") (:form . "unrecognized") (:end . 150)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 191) (:start . 190)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 201)\n  (:start . 192) (:id . 73))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 220)\n  (:start . 211) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "tcr-signalling") (:form . "TCR-signalling")\n  (:end . 238) (:start . 224) (:id . 77))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 245)\n  (:start . 239) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 249) (:start . 246)\n  (:id . 79))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 259)\n  (:start . 250) (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 262) (:start . 260)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 264) (:start . 263)\n  (:id . 82))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 276)\n  (:start . 265) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 279) (:start . 277)\n  (:id . 84))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 286)\n  (:start . 280) (:id . 85))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 298)\n  (:start . 287) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 299) (:start . 298)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1000.10) (:did . :|9115394|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009354@unknown@formal@none@1@S@NF-kappa B-independent suppression of HIV expression by ascorbic acid.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "b-independent") (:form . "B-independent")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 34)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "ascorbic") (:form . "ascorbic") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1001.1) (:did . :|9115810|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009355@unknown@formal@none@1@S@Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha).@(((:tag . "JJ") (:stem . "ascorbic") (:form . "Ascorbic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 98)\n  (:start . 90) (:id . 60))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 121)\n  (:start . 110) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 149)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 194)\n  (:start . 182) (:id . 75))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 203)\n  (:start . 195) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 205) (:start . 204)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 214)\n  (:start . 205) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1001.2) (:did . :|9115810|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009356@unknown@formal@none@1@S@To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF-kappa B, we carried out gel shift analysis on nuclear extracts prepared under different conditions of cell stimulation in the presence or absence of ascorbate, N-acetylcysteine (NAC), or zidovudine (AZT).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mediate") (:form . 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5009357@unknown@formal@none@1@S@Pretreatment of ACH-2 T cells by NAC followed by stimulation with PMA, TNF-alpha, or hydrogen peroxide (H2O2) resulted in strong suppression of NF-kappa B activation.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 128)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 140)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 152)\n  (:start . 144) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1001.4) (:did . :|9115810|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009358@unknown@formal@none@1@S@In contrast, neither ascorbate nor AZT affected NF-kappa B activity under all three induction conditions in the ACH-2 cell line.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AZT") (:form . "AZT") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "affect") (:form . "affected") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1001.5.1) (:span 13 20 31 34)))\n (:nscopes ((:id . :x1001.5.1) (:span 13 127)))\n (:identifiers (:sid . :s1001.5) (:did . :|9115810|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009360@unknown@formal@none@1@S@These results suggest that the molecular mechanism of HIV inhibition by ascorbate is not mediated via NF-kappa B inhibition, unlike that seen with other antioxidants.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 165)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1001.7.2) (:span 14 21)))\n (:ncues ((:id . :x1001.7.1) (:span 85 88)))\n (:hscopes ((:id . :x1001.7.2) (:span 14 165)))\n (:nscopes ((:id . :x1001.7.1) (:span 27 123)))\n (:identifiers (:sid . :s1001.7) (:did . :|9115810|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009361@unknown@formal@none@1@S@Lineage- and stage-specific expression of runt box polypeptides in primitive and definitive hematopoiesis.@(((:tag . "NN") (:stem . "lineage-") (:form . "Lineage-") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primitive") (:form . "primitive") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "definitive") (:form . "definitive") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 105) (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1002.1) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009362@unknown@formal@none@1@S@Translocations involving the human CBFA2 locus have been associated with leukemia.@(((:tag . "NNS") (:stem . "translocation") (:form . "Translocations")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cbfa2") (:form . "CBFA2") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1002.2) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009363@unknown@formal@none@1@S@This gene, originally named AML1, is a human homologue of the Drosophila gene runt that controls early events in fly embryogenesis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "aml1") (:form . "AML1") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 54)\n  (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 72)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "embryogenesis") (:form . "embryogenesis")\n  (:end . 130) (:start . 117) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1002.3) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009364@unknown@formal@none@1@S@To clarify the role of mammalian runt products in normal and leukemic hematopoiesis, we have studied their pattern of expression in mouse hematopoietic tissues in the adult and during ontogeny using an anti-runt box antiserum.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "clarify") (:form . "clarify") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 151) (:start . 138) (:id . 65))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "adult") (:form . "adult") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 183)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "ontogeny") (:form . "ontogeny") (:end . 192)\n  (:start . 184) (:id . 72))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 198) (:start . 193)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 201) (:start . 199)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "anti-runt") (:form . "anti-runt") (:end . 211)\n  (:start . 202) (:id . 75))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 215) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "antiserum") (:form . "antiserum") (:end . 225)\n  (:start . 216) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1002.4) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009365@unknown@formal@none@1@S@In the adult bone marrow, we found expression of runt polypeptides in differentiating myeloid cells and in B lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "polypeptide") (:form . "polypeptides") (:end . 66)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 85) (:start . 70) (:id . 55))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1002.5) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009366@unknown@formal@none@1@S@Within the erythroid lineage, runt expression is biphasic, clearly present in the erythroblasts of early blood islands and of the fetal liver, but absent in the adult.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "erythroblast") (:form . "erythroblasts")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "island") (:form . "islands") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "liver") (:form . "liver") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "adult") (:form . "adult") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1002.6.1) (:span 147 153)))\n (:nscopes ((:id . :x1002.6.1) (:span 147 166)))\n (:identifiers (:sid . :s1002.6) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009367@unknown@formal@none@1@S@Biochemical analysis by Western blotting of fetal and adult hematopoietic populations shows several runt isoforms.@(((:tag . "JJ") (:stem . "biochemical") (:form . "Biochemical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "runt") (:form . "runt") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1002.7) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009368@unknown@formal@none@1@S@At least one of them appears to be myeloid specific.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x1002.8.1) (:span 21 28)))\n (:hscopes ((:id . :x1002.8.1) (:span 0 51)))\n (:identifiers (:sid . :s1002.8) (:did . :|9116279|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009370@unknown@formal@none@1@S@Cell-to-cell contact between peripheral blood lymphocytes and transfected human colonic carcinoma cell line HT29 activates transcription of the long terminal repeats (LTR) of human immunodeficiency virus.@(((:tag . "JJ") (:stem . "cell-to-cell") (:form . "Cell-to-cell") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 57)\n  (:start . 46) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 73)\n  (:start . 62) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "colonic") (:form . "colonic") (:end . 87)\n  (:start . 80) (:id . 51))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 97)\n  (:start . 88) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 107) (:start . 103)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ht29") (:form . "HT29") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 122)\n  (:start . 113) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 148) (:start . 144)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 157)\n  (:start . 149) (:id . 61))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 165)\n  (:start . 158) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 170) (:start . 167)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 197) (:start . 181) (:id . 68))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 203)\n  (:start . 198) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1003.2) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009371@unknown@formal@none@1@S@HIV-1 LTR transcription is controlled by a complex array of virus-encoded and cellular proteins.@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "array") (:form . "array") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "virus-encoded") (:form . "virus-encoded")\n  (:end . 73) (:start . 60) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1003.3) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009372@unknown@formal@none@1@S@Using various constructs expressing a lacZ reporter gene under the control of the intact or three deleted forms of HIV-1 LTR, we obtained evidence that the kappaB regulatory elements located in the U3 region are involved in cell-to-cell activation of HIV-1 LTR.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lacz") (:form . "lacZ") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "obtain") (:form . "obtained") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 182)\n  (:start . 174) (:id . 71))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 190)\n  (:start . 183) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 200) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 211) (:start . 208)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 220)\n  (:start . 212) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "cell-to-cell") (:form . "cell-to-cell") (:end . 236)\n  (:start . 224) (:id . 80))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 247)\n  (:start . 237) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 250) (:start . 248)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 256)\n  (:start . 251) (:id . 83))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 260) (:start . 257)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1003.4) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009373@unknown@formal@none@1@S@Cell-to-cell contact activates in vitro binding of the nuclear factor kappaB (NF-kappaB) p50/p65 heterodimer to an HIV-1 kappaB oligonucleotide.@(((:tag . "JJ") (:stem . "cell-to-cell") (:form . "Cell-to-cell") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 143) (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1003.5) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009374@unknown@formal@none@1@S@Cell-to-cell contact activation of NF-kappaB was only partially inhibited by 100 microM pyrrolidine dithiocarbamate and was not correlated with a significant decrease of cellular inhibitor kappaB alpha.@(((:tag . "JJ") (:stem . "cell-to-cell") (:form . "Cell-to-cell") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 99)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 115) (:start . 100) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 157)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 166)\n  (:start . 158) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 178)\n  (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 188)\n  (:start . 179) (:id . 66))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 195)\n  (:start . 189) (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 201)\n  (:start . 196) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1003.6.1) (:span 124 127)))\n (:nscopes ((:id . :x1003.6.1) (:span 120 201)))\n (:identifiers (:sid . :s1003.6) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009375@unknown@formal@none@1@S@NF-kappaB nuclear activation was not detectable before 1 h after cell contact and was dependent on protein synthesis.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1003.7.1) (:span 33 36)))\n (:nscopes ((:id . :x1003.7.1) (:span 33 77)))\n (:identifiers (:sid . :s1003.7) (:did . :|9119025|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009376@unknown@formal@none@1@S@HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.@(((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd3/cd28") (:form . "CD3/CD28") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x1004.1.1) (:span 9 12)))\n (:nscopes ((:id . :x1004.1.1) (:span 9 68)))\n (:identifiers (:sid . :s1004.1) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009377@unknown@formal@none@1@S@In this report, we demonstrate that the T cell tropic strain of HIV, LAI, does not replicate in naive CD4 T cells stimulated by cross-linking CD3 and CD28.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tropic") (:form . "tropic") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 72) (:start . 69)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 78) (:start . 74)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 60))\n ((:tag . "VB") (:stem . "replicate") (:form . "replicate") (:end . 92)\n  (:start . 83) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 101) (:start . 96)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 105) (:start . 102)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 66))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 124)\n  (:start . 114) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 141) (:start . 128) (:id . 69))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 145) (:start . 142)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 154) (:start . 150)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1004.2.1) (:span 79 82)))\n (:nscopes ((:id . :x1004.2.1) (:span 79 154)))\n (:identifiers (:sid . :s1004.2) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009378@unknown@formal@none@1@S@In contrast, LAI replicates well in memory CD4 T cells stimulated in the same way.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "replicate") (:form . "replicates") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1004.3) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009380@unknown@formal@none@1@S@These studies were conducted with highly purified (FACS-isolated) subsets of CD4 T cells identified by expression of both CD45RA and CD62L.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "facs-isolated") (:form . "FACS-isolated")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CD45RA") (:form . "CD45RA") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CD62L") (:form . "CD62L") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1004.5) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009381@unknown@formal@none@1@S@Remixing of purified T cells showed that naive T cells do not suppress LAI replication in memory T cells and that memory T cells do not restore LAI expression in naive T cells.@(((:tag . "NN") (:stem . "remixing") (:form . "Remixing") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 86)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 143)\n  (:start . 136) (:id . 68))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 147) (:start . 144)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 167)\n  (:start . 162) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 169) (:start . 168)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x1004.6.1) (:span 132 135))\n  ((:id . :x1004.6.2) (:span 58 61)))\n (:nscopes ((:id . :x1004.6.1) (:span 132 175))\n  ((:id . :x1004.6.2) (:span 58 104)))\n (:identifiers (:sid . :s1004.6) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009382@unknown@formal@none@1@S@The suppression of productive LAI replication in naive T cells is not due to differential expression of viral coreceptors, nor is it due to inhibition of activation of the important HIV transcription factors, nuclear factor-kappaB and activator protein-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 89)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "coreceptor") (:form . "coreceptors") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 150)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 164)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 181)\n  (:start . 172) (:id . 72))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 199) (:start . 186) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 207)\n  (:start . 200) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 216)\n  (:start . 209) (:id . 77))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 230) (:start . 217) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 234) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 244)\n  (:start . 235) (:id . 80))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 254)\n  (:start . 245) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x1004.7.1) (:span 66 69 123 126)))\n (:nscopes ((:id . :x1004.7.1) (:span 66 254)))\n (:identifiers (:sid . :s1004.7) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009383@unknown@formal@none@1@S@The inherent resistance of naive T cells to productive HIV infection, coupled with their proliferative advantage as demonstrated here, provides a sound basis for proposed clinical therapies using ex vivo expansion and reinfusion of CD4 T cells from HIV-infected adults.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inherent") (:form . "inherent") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 88)\n  (:start . 83) (:id . 56))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 128)\n  (:start . 116) (:id . 60))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "sound") (:form . "sound") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 179)\n  (:start . 171) (:id . 69))\n ((:tag . "NNS") (:stem . "therapy") (:form . "therapies") (:end . 189)\n  (:start . 180) (:id . 70))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 195) (:start . 190)\n  (:id . 71))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 203) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 213)\n  (:start . 204) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 217) (:start . 214)\n  (:id . 75))\n ((:tag . "NN") (:stem . "reinfusion") (:form . "reinfusion") (:end . 228)\n  (:start . 218) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 235) (:start . 232)\n  (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 237) (:start . 236)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 243)\n  (:start . 238) (:id . 80))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 248) (:start . 244)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 261)\n  (:start . 249) (:id . 82))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 268)\n  (:start . 262) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1004.8) (:did . :|9119999|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009384@unknown@formal@none@1@S@Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "RB") (:stem . "potently") (:form . "potently") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "up-regulates") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1005.1) (:did . :|9120310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009385@unknown@formal@none@1@S@The complex network of cytokines that are involved in inflammatory and immunoregulatory responses plays a critical role in the pathogenesis of HIV infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 87) (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 139)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1005.2) (:did . :|9120310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009386@unknown@formal@none@1@S@RANTES (regulated upon activation, normal T cell expressed and secreted) is a cytokine that belongs to the beta-chemokine family; it is chemoattractant for CD4+/CD45RO T cells, it is produced by various cell types including CD8+ and CD4+ T cells as well as monocytes/macrophages, and has recently been shown to suppress replication of macrophage-tropic strains of HIV in CD4+ T cells.@(((:tag . "NN") (:stem . "rantes") (:form . "RANTES") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . 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5009387@unknown@formal@none@1@S@To investigate the molecular mechanisms of RANTES expression, the RANTES promoter region was analyzed by transient expression and gel-mobility shift assays.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RANTES") (:form . "RANTES") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gel-mobility") (:form . "gel-mobility") (:end . 142)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 155)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1005.4) (:did . :|9120310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009388@unknown@formal@none@1@S@We demonstrate that: 1) RANTES promoter activity is up-regulated by PMA plus ionomycin, coexpression of the p65 subunit of nuclear factor (NF)-kappa B, the proinflammatory cytokines TNF-alpha and IL-1 beta, and the CD28 costimulatory pathway; 2) the RANTES promoter region contains four NF-kappa B binding sites at positions -30, -44, -213, and -579 relative to the transcription start site; 3) one site (-213) is an NF-AT (nuclear factor of activated T cells) binding site that also has weak affinity to NF-kappa B, and the most distal site (-579) also serves as a CD28-responsive element; and 4) mutation on any of those NF-kappa B sites or coexpression of I kappa B alpha (cytoplasmic inhibitor of NF-kappa B) markedly reduced the promoter activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . 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5009390@unknown@formal@none@1@S@Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain.@(((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nfatx1") (:form . "NFATx1") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "calcineurin-regulated")\n  (:form . "calcineurin-regulated") (:end . 66) (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 84)\n  (:start . 78) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1006.1) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009391@unknown@formal@none@1@S@The nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located in the promoters of several cytokine genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1006.2) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009392@unknown@formal@none@1@S@NFATx1, which is preferentially expressed in the thymus and peripheral blood leukocytes, is one of four members of the NFAT family of transcription factors.@(((:tag . "NNP") (:stem . "NFATx1") (:form . "NFATx1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 31) (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 147) (:start . 134) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1006.3) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009393@unknown@formal@none@1@S@We have performed domain analysis of NFATx1 by examining the effects of deletion mutations.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nfatx1") (:form . "NFATx1") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "examine") (:form . "examining") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1006.4) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009394@unknown@formal@none@1@S@We found that NFATx1 DNA binding activity and interaction with AP-1 polypeptides were dependent on its central Rel similarity region and that transcriptional activation was reduced by deletions of either its N-terminal domain or its C-terminal domain, suggesting the presence of intrinsic transcriptional activation motifs in both regions.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nfatx1") (:form . "NFATx1") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . 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"domain") (:end . 250)\n  (:start . 244) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 251) (:start . 250)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 262)\n  (:start . 252) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 266) (:start . 263)\n  (:id . 81))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 275)\n  (:start . 267) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 278) (:start . 276)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 288)\n  (:start . 279) (:id . 84))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 304) (:start . 289) (:id . 85))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 315)\n  (:start . 305) (:id . 86))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 322)\n  (:start . 316) (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 325) (:start . 323)\n  (:id . 88))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 330) (:start . 326)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 338)\n  (:start . 331) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 339) (:start . 338)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x1006.5.1) (:span 252 262)))\n (:hscopes ((:id . :x1006.5.1) (:span 252 338)))\n (:identifiers (:sid . :s1006.5) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009395@unknown@formal@none@1@S@We also identified a potent inhibitory sequence within its N-terminal domain.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1006.6) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009396@unknown@formal@none@1@S@We show that the inactivation of the inhibition was dependent on the activity of calcineurin, a calcium-calmodulin-dependent phosphatase.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "calcium-calmodulin-dependent")\n  (:form . "calcium-calmodulin-dependent") (:end . 124) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 136)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1006.7) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009397@unknown@formal@none@1@S@We also show that calcineurin associated with the N-terminal domain of NFATx1 at multiple docking sites and caused a reduction of size, indicative of dephosphorylation, in NFATx1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nfatx1") (:form . "NFATx1") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "indicative") (:form . "indicative") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dephosphorylation") (:form . "dephosphorylation")\n  (:end . 167) (:start . 150) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NFATx1") (:form . "NFATx1") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1006.8) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009398@unknown@formal@none@1@S@We have mapped the inhibitory activity to less than 60 residues, containing motifs that are conserved in all NFAT proteins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1006.9) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009400@unknown@formal@none@1@S@Our results support the model proposing that the N-terminal domain confers calcium-signaling dependence on NFATx1 transactivation activity by regulating its intracellular localization through a protein module that associates with calcineurin and is a target of its phosphatase activity.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "propose") (:form . "proposing") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "calcium-signaling") (:form . "calcium-signaling")\n  (:end . 92) (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "nfatx1") (:form . "NFATx1") (:end . 113)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 129) (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 138)\n  (:start . 130) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 152)\n  (:start . 142) (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 156) (:start . 153)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 170) (:start . 157) (:id . 62))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 183)\n  (:start . 171) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 191)\n  (:start . 184) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 201)\n  (:start . 194) (:id . 66))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 208)\n  (:start . 202) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 213) (:start . 209)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 224)\n  (:start . 214) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 229) (:start . 225)\n  (:id . 70))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 241)\n  (:start . 230) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 245) (:start . 242)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 248) (:start . 246)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 250) (:start . 249)\n  (:id . 74))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 257)\n  (:start . 251) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 260) (:start . 258)\n  (:id . 76))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 264) (:start . 261)\n  (:id . 77))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 276)\n  (:start . 265) (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 285)\n  (:start . 277) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1006.11.1) (:span 30 39)))\n (:hscopes ((:id . :x1006.11.1) (:span 30 285)))\n (:identifiers (:sid . :s1006.11) (:did . :|9121455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009401@unknown@formal@none@1@S@Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.@(((:tag . "JJ") (:stem . "neuronal") (:form . "Neuronal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1007.1) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009402@unknown@formal@none@1@S@Nitric oxide subserves diverse physiologic roles in the nervous system.@(((:tag . "JJ") (:stem . "nitric") (:form . "Nitric") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "subserve") (:form . "subserves") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1007.2) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009403@unknown@formal@none@1@S@NO is produced from at least three different NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS, and immunologic NOS (iNOS).@(((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NOS") (:form . "NOS") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 71)\n  (:start . 63) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "neuronal") (:form . "neuronal") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "nos") (:form . "NOS") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nnos") (:form . "nNOS") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 105)\n  (:start . 94) (:id . 63))\n ((:tag . "NN") (:stem . "nos") (:form . "NOS") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "immunologic") (:form . "immunologic") (:end . 126)\n  (:start . 115) (:id . 67))\n ((:tag . "NN") (:stem . "nos") (:form . "NOS") (:end . 130) (:start . 127)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 69))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 136) (:start . 132)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1007.3) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009404@unknown@formal@none@1@S@We show that nNOS is the predominant isoform constitutively expressed in glia.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nnos") (:form . "nNOS") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "predominant") (:form . "predominant") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 59) (:start . 45) (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glia") (:form . "glia") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1007.4) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009405@unknown@formal@none@1@S@NO derived from nNOS in glia inhibits the transcription factor nuclear factor kappaB (NF kappaB) as NOS inhibitors enhance basal NF kappaB activation.@(((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nnos") (:form . "nNOS") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "glia") (:form . "glia") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NOS") (:form . "NOS") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1007.5) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009406@unknown@formal@none@1@S@Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of NF kappaB in most cells; however, we show that PDTC is also a potent scavenger of NO through formation of mononitrosyl iron complexes with PDTC.@(((:tag . "NNP") (:stem . "Pyrrolidine") (:form . "Pyrrolidine") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 105) (:start . 101)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 113) (:start . 109)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 122)\n  (:start . 116) (:id . 66))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 132)\n  (:start . 123) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 138) (:start . 136)\n  (:id . 69))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 146)\n  (:start . 139) (:id . 70))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 156)\n  (:start . 147) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 72))\n ((:tag . "NN") (:stem . "mononitrosyl") (:form . "mononitrosyl") (:end . 172)\n  (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "iron") (:form . "iron") (:end . 177) (:start . 173)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 187)\n  (:start . 178) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 197) (:start . 193)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1007.6) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009407@unknown@formal@none@1@S@In Jurkat cells, a human T-cell lymphoma cell line, tumor necrosis factor-alpha (TNF-alpha) induces NF kappaB activation that is inhibited by PDTC.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 79)\n  (:start . 67) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1007.7) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009408@unknown@formal@none@1@S@Contrary to the results in Jurkat cells, PDTC did not inhibit tumor necrosis factor-alpha-induced NF kappaB activation in astrocytes; instead PDTC itself induces NF kappaB activation in astrocytes, and this may be related to scavenging of endogenously produced NO by the PDTC iron complex.@(((:tag . "JJ") (:stem . "contrary") (:form . "Contrary") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . 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5009410@unknown@formal@none@1@S@NF kappaB activation in glia from mice lacking nNOS responds more rapidly to PDTC compared with astrocytes from wild-type mice.@(((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glia") (:form . "glia") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "nnos") (:form . "nNOS") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "respond") (:form . "responds") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 126)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1007.10.1) (:span 39 46)))\n (:nscopes ((:id . :x1007.10.1) (:span 39 51)))\n (:identifiers (:sid . :s1007.10) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009411@unknown@formal@none@1@S@Our data suggest that nNOS in astrocytes regulates NF kappaB activity and iNOS expression, and indicate a novel regulatory role for nNOS in tonically suppressing central nervous system, NF kappaB-regulated genes.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "nnos") (:form . "nNOS") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nnos") (:form . "nNOS") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "RB") (:stem . "tonically") (:form . "tonically") (:end . 149)\n  (:start . 140) (:id . 66))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 161)\n  (:start . 150) (:id . 67))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 169)\n  (:start . 162) (:id . 68))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "NN") (:stem . "nf") (:form . "NF") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "kappab-regulated") (:form . "kappaB-regulated")\n  (:end . 205) (:start . 189) (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 211)\n  (:start . 206) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1007.11.1) (:span 95 103))\n  ((:id . :x1007.11.2) (:span 9 16)))\n (:hscopes ((:id . :x1007.11.1) (:span 95 211))\n  ((:id . :x1007.11.2) (:span 9 89)))\n (:identifiers (:sid . :s1007.11) (:did . :|9122255|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009412@unknown@formal@none@1@S@Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 80)\n  (:start . 69) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1008.1) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009413@unknown@formal@none@1@S@Activated neutrophils have the ability to upregulate the expression of many genes, in particular those encoding cytokines and chemokines, and to subsequently release the corresponding proteins.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VB") (:stem . "upregulate") (:form . "upregulate") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 157)\n  (:start . 145) (:id . 65))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 165)\n  (:start . 158) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 183) (:start . 170) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 192)\n  (:start . 184) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1008.2) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009414@unknown@formal@none@1@S@Although little is known to date concerning the regulation of gene transcription in neutrophils, it is noteworthy that many of these genes depend on the activation of transcription factors, such as NF-kappaB, for inducible expression.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "concern") (:form . "concerning") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "noteworthy") (:form . "noteworthy") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "VBP") (:stem . "depend") (:form . "depend") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 163)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 180) (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 188)\n  (:start . 181) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 207)\n  (:start . 198) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 212) (:start . 209)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 222)\n  (:start . 213) (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 233)\n  (:start . 223) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1008.3) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009415@unknown@formal@none@1@S@We therefore investigated whether NF-kappaB/Rel proteins are expressed in human neutrophils, as well as their fate on cell activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "fate") (:form . "fate") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1008.4.1) (:span 26 33)))\n (:hscopes ((:id . :x1008.4.1) (:span 26 91)))\n (:identifiers (:sid . :s1008.4) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009416@unknown@formal@none@1@S@We now report that dimers consisting of p50 NFkappaB1, p65 RelA, and/or c-Rel are present in neutrophils and that the greater part of these protein complexes is physically associated with cytoplasmic IkappaB-alpha in resting cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nfkappab1") (:form . "NFkappaB1") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 104)\n  (:start . 93) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 125)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 157)\n  (:start . 148) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 171)\n  (:start . 161) (:id . 71))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 182)\n  (:start . 172) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 199)\n  (:start . 188) (:id . 74))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 213) (:start . 200) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 224)\n  (:start . 217) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 230)\n  (:start . 225) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1008.5) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009417@unknown@formal@none@1@S@Following neutrophil stimulation with proinflammatory agonists (such as lipopolysaccharide [LPS], tumor necrosis factor-alpha [TNF-alpha], and fMet-Leu-Phe) that induce the production of cytokines and chemokines in these cells, NF-kappaB/Rel proteins translocated to nuclear fractions, resulting in a transient induction of NF-kappaB DNA binding activity, as determined in gel mobility shift assays.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 32)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 53) (:start . 38) (:id . 46))\n ((:tag . "NNS") (:stem . "agonist") (:form . 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"NF-kappaB/Rel")\n  (:end . 241) (:start . 228) (:id . 78))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 250)\n  (:start . 242) (:id . 79))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 263)\n  (:start . 251) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 266) (:start . 264)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 274)\n  (:start . 267) (:id . 82))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 284)\n  (:start . 275) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 285) (:start . 284)\n  (:id . 84))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 295)\n  (:start . 286) (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 298) (:start . 296)\n  (:id . 86))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 300) (:start . 299)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "transient") (:form . 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"in") (:end . 372) (:start . 370)\n  (:id . 98))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 376) (:start . 373)\n  (:id . 99))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 385)\n  (:start . 377) (:id . 100))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 391)\n  (:start . 386) (:id . 101))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 398)\n  (:start . 392) (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 399) (:start . 398)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s1008.6) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009418@unknown@formal@none@1@S@The onset of both processes was found to be closely paralleled by, and dependent on, IkappaB-alpha degradation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "VBN") (:stem . "parallel") (:form . "paralleled") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 98) (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1008.7) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009420@unknown@formal@none@1@S@To our knowledge, this constitutes the first indication that NF-kappaB activation may underlie the action of proinflammatory stimuli towards human neutrophil gene expression and, as such, adds a new facet to our understanding of neutrophil biology.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "constitute") (:form . "constitutes") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "indication") (:form . "indication") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 124) (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 162) (:start . 158)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 186) (:start . 182)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "add") (:form . "adds") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "facet") (:form . "facet") (:end . 204)\n  (:start . 199) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 211) (:start . 208)\n  (:id . 76))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 225) (:start . 212) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 239)\n  (:start . 229) (:id . 79))\n ((:tag . "NN") (:stem . "biology") (:form . "biology") (:end . 247)\n  (:start . 240) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1008.9.1) (:span 82 85))\n  ((:id . :x1008.9.2) (:span 45 55)))\n (:hscopes ((:id . :x1008.9.1) (:span 82 173))\n  ((:id . :x1008.9.2) (:span 45 173)))\n (:identifiers (:sid . :s1008.9) (:did . :|9129050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009421@unknown@formal@none@1@S@Regulation of human epsilon germline transcription: role of B-cell-specific activator protein.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1009.1) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009422@unknown@formal@none@1@S@Germline transcripts initiate from promoters upstream of the immunoglobulin switch region, and are necessary to target the appropriate switch region for recombination and switching.@(((:tag . "NNP") (:stem . "Germline") (:form . "Germline") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "initiate") (:form . "initiate") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 75) (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 82)\n  (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 89)\n  (:start . 83) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "VB") (:stem . "target") (:form . "target") (:end . 118)\n  (:start . 112) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 134)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 148)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 166) (:start . 153) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 180)\n  (:start . 171) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1009.2) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009423@unknown@formal@none@1@S@Different cytokines activate transcription at the appropriate germline promoter.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1009.3) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009424@unknown@formal@none@1@S@Because binding sites for B-cell-specific activator protein (BSAP) are located upstream of several switch regions in the immunoglobulin heavy chain gene cluster, BSAP might play a role in the regulation of germline transcription and isotype switching.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 15) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 113)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 135) (:start . 121) (:id . 61))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 172)\n  (:start . 167) (:id . 68))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 202)\n  (:start . 192) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 228) (:start . 215) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 232) (:start . 229)\n  (:id . 78))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 240)\n  (:start . 233) (:id . 79))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 250)\n  (:start . 241) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1009.4.1) (:span 167 172)))\n (:hscopes ((:id . :x1009.4.1) (:span 167 250)))\n (:identifiers (:sid . :s1009.4) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009425@unknown@formal@none@1@S@We investigated whether BSAP plays a role in the transcriptional regulation of the epsilon germline promoter in human B cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 64) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1009.5.1) (:span 16 23)))\n (:hscopes ((:id . :x1009.5.1) (:span 16 125)))\n (:identifiers (:sid . :s1009.5) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009426@unknown@formal@none@1@S@Our results showed that BSAP plays a role in both IL-4-dependent induction and CD40-mediated upregulation of human epsilon germline transcription.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "il-4-dependent") (:form . "IL-4-dependent")\n  (:end . 64) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 145) (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1009.6) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009427@unknown@formal@none@1@S@BSAP is unique among the transcription factors that regulate epsilon germline expression, because it is B cell specific, and is at the merging point of two signalling pathways that are critical for IgE switching.@(((:tag . "NNP") (:stem . "BSAP") (:form . "BSAP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "merging") (:form . "merging") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 166)\n  (:start . 156) (:id . 70))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 175)\n  (:start . 167) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 180) (:start . 176)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 193)\n  (:start . 185) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 211)\n  (:start . 202) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1009.7) (:did . :|9130477|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009428@unknown@formal@none@1@S@Retinoic acid-induced modulation of IL-2 mRNA production and IL-2 receptor expression on T cells.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "acid-induced") (:form . "acid-induced") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1010.1) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009430@unknown@formal@none@1@S@Our laboratory has shown that RA can enhance in vitro polyclonal B cell immunoglobulin (Ig) response.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "polyclonal") (:form . "polyclonal") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 86) (:start . 72) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1010.3) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009431@unknown@formal@none@1@S@Investigating cytokines known to affect B cell differentiation, we have recently shown that IL-6 production is augmented by RA.@(((:tag . "VBG") (:stem . "investigate") (:form . "Investigating") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 29) (:start . 24)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "augment") (:form . "augmented") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1010.4) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009432@unknown@formal@none@1@S@In the present study we have examined the immune modulating effects of RA on IL-2 mRNA, another important cytokine for B cell immunoglobulin production, the expression of IL-2 receptors on T cells, and the RA nuclear receptors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "modulating") (:form . "modulating") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 140) (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 151)\n  (:start . 141) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 167)\n  (:start . 157) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 185)\n  (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 208) (:start . 206)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 216)\n  (:start . 209) (:id . 80))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 226)\n  (:start . 217) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1010.5) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009433@unknown@formal@none@1@S@METHODS: Purified T cells were obtained from adenoidal tissues, and incubated with RA (10(-7) M) or DMSO solvent/media control for 0, 6-8, and 24 h.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "purify") (:form . "Purified") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adenoidal") (:form . "adenoidal") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "10(-7)") (:form . "10(-7)") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "DMSO") (:form . "DMSO") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "NN") (:stem . "solvent/media") (:form . "solvent/media")\n  (:end . 118) (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "CD") (:stem . "6-8") (:form . "6-8") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 70))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 145) (:start . 143)\n  (:id . 71))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 147) (:start . 146)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1010.6) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009434@unknown@formal@none@1@S@Total mRNA was extracted from T cells, and using RT-PCR, changes in the production of IL-2 and RA receptors (RAR)-alpha,beta,gamma mRNA were determined.@(((:tag . "JJ") (:stem . "total") (:form . "Total") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 82)\n  (:start . 72) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 107)\n  (:start . 98) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RAR)-alpha,beta,gamma")\n  (:form . "RAR)-alpha,beta,gamma") (:end . 130) (:start . 109) (:id . 64))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 151)\n  (:start . 141) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1010.7) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009435@unknown@formal@none@1@S@The effects of RA on IL-2-alpha receptor expression was determined by flow cytometry on T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-2-alpha") (:form . "IL-2-alpha") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1010.8) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009436@unknown@formal@none@1@S@CONCLUSION: These studies suggest that RA can augment IL-2 mRNA production by T cells with a possible paracrine effect on IL-2R-alpha expression.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "These") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "paracrine") (:form . "paracrine") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-2R-alpha") (:form . "IL-2R-alpha") (:end . 133)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1010.9.1) (:span 93 101))\n  ((:id . :x1010.9.2) (:span 26 33)))\n (:hscopes ((:id . :x1010.9.1) (:span 93 144))\n  ((:id . :x1010.9.2) (:span 26 144)))\n (:identifiers (:sid . :s1010.9) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009437@unknown@formal@none@1@S@These changes appear to be mediated by RAR-alpha.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RAR-alpha") (:form . "RAR-alpha") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:hcues ((:id . :x1010.10.1) (:span 14 20)))\n (:hscopes ((:id . :x1010.10.1) (:span 0 48)))\n (:identifiers (:sid . :s1010.10) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009438@unknown@formal@none@1@S@Thus, IL-2 may be another important cytokine modulated by RA in the immune response.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1010.11.1) (:span 11 14)))\n (:hscopes ((:id . :x1010.11.1) (:span 11 83)))\n (:identifiers (:sid . :s1010.11) (:did . :|9130512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009440@unknown@formal@none@1@S@We investigated the functional role of Itk, a member of the cytoplasmic tyrosine kinase Tec family, in T cell activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 71)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "Tec") (:form . "Tec") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1011.2) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009441@unknown@formal@none@1@S@Stimulation of either CD2 or T cell receptor (TCR)/CD3 on Tcells by monoclonal antibody-mediated cross-linking induced tyrosine phosphorylation of Itk, which was maximal as early as 1 min after stimulation.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCR)/CD3") (:form . "TCR)/CD3") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "tcell") (:form . "Tcells") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 78)\n  (:start . 68) (:id . 55))\n ((:tag . "JJ") (:stem . "antibody-mediated") (:form . "antibody-mediated")\n  (:end . 96) (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 110) (:start . 97) (:id . 57))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 143) (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 178)\n  (:start . 173) (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 183) (:start . 182)\n  (:id . 70))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 193)\n  (:start . 188) (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 205)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1011.3) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009442@unknown@formal@none@1@S@The tyrosine kinase activity in the anti-Itk immunoprecipitate was significantly activated upon these stimulations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-itk") (:form . "anti-Itk") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "immunoprecipitate") (:form . "immunoprecipitate")\n  (:end . 62) (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 80) (:start . 67) (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 101) (:start . 96)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "stimulation") (:form . "stimulations") (:end . 114)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1011.4) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009443@unknown@formal@none@1@S@Interleukin-2 (IL-2) promoter activity stimulated by cross-linking of CD2, TCR/CD3, and CD28 with antibodies was significantly reduced by transient expression of an Itk mutant lacking the kinase activity.@(((:tag . "NN") (:stem . "interleukin-2") (:form . "Interleukin-2")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TCR/CD3") (:form . "TCR/CD3") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 126) (:start . 113) (:id . 61))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 194)\n  (:start . 188) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 203)\n  (:start . 195) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1011.5.1) (:span 176 183)))\n (:nscopes ((:id . :x1011.5.1) (:span 176 203)))\n (:identifiers (:sid . :s1011.5) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009444@unknown@formal@none@1@S@The reduction paralleled a decrease in tyrosine phosphorylation of endogenous wild-type Itk.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "parallel") (:form . "paralleled") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 63) (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "itk") (:form . "Itk") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1011.6) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009445@unknown@formal@none@1@S@Stimulation of CD2 or TCR/CD3 induced activation of the nuclear factor of activated T cells (NFAT), the binding site of which is included in the IL-2 gene promoter.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCR/CD3") (:form . "TCR/CD3") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 125)\n  (:start . 120) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "include") (:form . "included") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 149) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 163)\n  (:start . 155) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1011.7) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009446@unknown@formal@none@1@S@The activation of NFAT was also impaired by expression of the Itk mutant.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "impair") (:form . "impaired") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1011.8) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009447@unknown@formal@none@1@S@These results demonstrate that Itk plays a role in IL-2 production, indicating a critical involvement of Itk in the initial stage of T cell activation by mediating signals from the TCR/CD3 complex, CD2, and CD28.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Itk") (:form . "Itk") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 150)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 163)\n  (:start . 154) (:id . 69))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 72))\n ((:tag . "NN") (:stem . "tcr/cd3") (:form . "TCR/CD3") (:end . 188)\n  (:start . 181) (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 196)\n  (:start . 189) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 211) (:start . 207)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1011.9.1) (:span 68 78)))\n (:hscopes ((:id . :x1011.9.1) (:span 68 211)))\n (:identifiers (:sid . :s1011.9) (:did . :|9130632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009448@unknown@formal@none@1@S@Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells.@(((:tag . "NNP") (:stem . "Jak3") (:form . "Jak3") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1012.1) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009450@unknown@formal@none@1@S@Although CD40 lacks intrinsic tyrosine kinase activity, its ligation induces protein tyrosine phosphorylation, which is necessary for several CD40-mediated events.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 109) (:start . 94) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 155) (:start . 142) (:id . 62))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 162)\n  (:start . 156) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1012.3.1) (:span 14 19)))\n (:nscopes ((:id . :x1012.3.1) (:span 14 54)))\n (:identifiers (:sid . :s1012.3) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009451@unknown@formal@none@1@S@We show that engagement of CD40 induces tyrosine phosphorylation and activation of Jak3 as well as of STAT3.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "jak3") (:form . "Jak3") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1012.4) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009452@unknown@formal@none@1@S@Jak3 is constitutively associated with CD40, and this interaction requires a proline-rich sequence in the membrane-proximal region of CD40.@(((:tag . "NNP") (:stem . "Jak3") (:form . "Jak3") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 22) (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "proline-rich") (:form . "proline-rich") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "membrane-proximal") (:form . "membrane-proximal")\n  (:end . 123) (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 138) (:start . 134)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1012.5) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009453@unknown@formal@none@1@S@Deletion of this sequence abolishes the capacity of CD40 to induce expression of CD23, ICAM-1, and lymphotoxin-alpha genes in B cells.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymphotoxin-alpha") (:form . "lymphotoxin-alpha")\n  (:end . 116) (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1012.6) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009454@unknown@formal@none@1@S@These results indicate that signaling through Jak3 is activated by CD40 and plays an important role in CD40-mediated functions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "Jak3") (:form . "Jak3") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 116) (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1012.7.1) (:span 14 27)))\n (:hscopes ((:id . :x1012.7.1) (:span 14 126)))\n (:identifiers (:sid . :s1012.7) (:did . :|9133417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009455@unknown@formal@none@1@S@The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "associated") (:form . "associated") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "a6h") (:form . "A6H") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1013.1.1) (:span 83 86)))\n (:nscopes ((:id . :x1013.1.1) (:span 83 99)))\n (:identifiers (:sid . :s1013.1) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009456@unknown@formal@none@1@S@The A6H monoclonal antibody (mAb) recognizes a 120,000-140,000 MW antigen that is expressed at similar densities on 85-90% of human CD4+ and CD8+ T cells and on renal cell carcinomas.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "120,000-140,000") (:form . "120,000-140,000")\n  (:end . 62) (:start . 47) (:id . 51))\n ((:tag . "NNP") (:stem . "MW") (:form . "MW") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "density") (:form . "densities") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "CD") (:stem . "85-90") (:form . "85-90") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "carcinoma") (:form . "carcinomas") (:end . 182)\n  (:start . 172) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1013.2) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009457@unknown@formal@none@1@S@The binding of the A6H mAb induced a costimulatory signal in anti-CD3 activated T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 50) (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1013.3) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009458@unknown@formal@none@1@S@In the present report, we show that A6H costimulated cell proliferation and cytokine production in purified CD4+ T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "a6h") (:form . "A6H") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "costimulate") (:form . "costimulated") (:end . 52)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1013.4) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009460@unknown@formal@none@1@S@CD4+ T cells costimulated with the A6H mAb upregulated CD80, CD86, CD71, interleukin-2 (IL-2)R alpha, IL-2R beta and IL-2R gamma, while no corresponding up-regulation of these cell surface molecules was seen in CD8+ T cells.@(((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "costimulate") (:form . "costimulated") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "upregulate") (:form . "upregulated") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "cd80") (:form . "CD80") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD86") (:form . "CD86") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD71") (:form . "CD71") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 86) (:start . 73) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-2)R") (:form . "IL-2)R") (:end . 94)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 107)\n  (:start . 102) (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 122)\n  (:start . 117) (:id . 65))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 128)\n  (:start . 123) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 138) (:start . 136)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 152) (:start . 139) (:id . 70))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 166) (:start . 153) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 175)\n  (:start . 170) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 180) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 188)\n  (:start . 181) (:id . 75))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 198)\n  (:start . 189) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 202) (:start . 199)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 207) (:start . 203)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 215) (:start . 211)\n  (:id . 80))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 217) (:start . 216)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 223)\n  (:start . 218) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x1013.6.1) (:span 136 138)))\n (:nscopes ((:id . :x1013.6.1) (:span 136 223)))\n (:identifiers (:sid . :s1013.6) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009461@unknown@formal@none@1@S@In order to investigate the nature of the A6H mAb costimulus at the transcriptional level we have examined induction of the transcription factors OCT-1, AP-1 and NF-kappa B which are known to be transcriptional regulators of several cytokine and cytokine receptor genes, including the IL-2 and IL-2R genes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . 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"and") (:end . 293) (:start . 290)\n  (:id . 89))\n ((:tag . "NN") (:stem . "il-2r") (:form . "IL-2R") (:end . 299)\n  (:start . 294) (:id . 90))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 305)\n  (:start . 300) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s1013.7) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009462@unknown@formal@none@1@S@Co-ligation of the A6H antigen and the CD3 complex induced expression of the transcription factor AP-1 in CD4+ T cells, whereas no increase in NF-kappa B and octamer-binding (Oct) proteins was seen compared to T cells stimulated with anti-CD3 alone.@(((:tag . "NNP") (:stem . "Co-ligation") (:form . "Co-ligation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 139)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "octamer-binding") (:form . "octamer-binding")\n  (:end . 173) (:start . 158) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Oct") (:form . "Oct") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 188)\n  (:start . 180) (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 197) (:start . 193)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 206)\n  (:start . 198) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 211) (:start . 210)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 217)\n  (:start . 212) (:id . 80))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 228)\n  (:start . 218) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 233) (:start . 229)\n  (:id . 82))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 242)\n  (:start . 234) (:id . 83))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 248)\n  (:start . 243) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x1013.8.1) (:span 128 130)))\n (:nscopes ((:id . :x1013.8.1) (:span 128 248)))\n (:identifiers (:sid . :s1013.8) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009463@unknown@formal@none@1@S@Furthermore, no induction of AP-1 was seen in A6H costimulated CD8+ T cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "costimulate") (:form . "costimulated") (:end . 62)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1013.9.1) (:span 13 15)))\n (:nscopes ((:id . :x1013.9.1) (:span 13 75)))\n (:identifiers (:sid . :s1013.9) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009464@unknown@formal@none@1@S@These results suggests that both proximal steps in CD8+ T-cell activation as well as the later phases are unresponsive to A6H ligation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unresponsive") (:form . "unresponsive") (:end . 118)\n  (:start . 106) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "a6h") (:form . "A6H") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1013.10.1) (:span 14 22)))\n (:hscopes ((:id . :x1013.10.1) (:span 14 134)))\n (:identifiers (:sid . :s1013.10) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009465@unknown@formal@none@1@S@Molecular differences of the A6H molecule or distinct regulation of the A6H transduced AP-1 activation pathway may exist in CD4+ and CD8+ T cell subpopulations.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "A6H") (:form . "A6H") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "subpopulation") (:form . "subpopulations")\n  (:end . 159) (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1013.11.1) (:span 111 114)))\n (:hscopes ((:id . :x1013.11.1) (:span 111 159)))\n (:identifiers (:sid . :s1013.11) (:did . :|9135552|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009466@unknown@formal@none@1@S@Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression.@(((:tag . "NN") (:stem . "structure") (:form . "Structure") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 81) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 171) (:start . 157) (:id . 69))\n ((:tag . "JJ") (:stem . "lineage-specific") (:form . "lineage-specific")\n  (:end . 188) (:start . 172) (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1014.1.1) (:span 133 136)))\n (:nscopes ((:id . :x1014.1.1) (:span 133 153)))\n (:identifiers (:sid . :s1014.1) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009467@unknown@formal@none@1@S@The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "mature") (:form . "maturing") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 122) (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 164)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1014.2) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009468@unknown@formal@none@1@S@Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fixed tissues.@(((:tag . "NNP") (:stem . "Epitope") (:form . "Epitope") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "strict") (:form . "strict") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "lineage-") (:form . "lineage-") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "stage-specific") (:form . "stage-specific")\n  (:end . 78) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MNDA") (:form . "MNDA") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "JJ") (:stem . "paraffin-embedded") (:form . "paraffin-embedded")\n  (:end . 150) (:start . 133) (:id . 64))\n ((:tag . "JJ") (:stem . "fixed") (:form . "fixed") (:end . 156)\n  (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1014.3) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009470@unknown@formal@none@1@S@Further analysis has revealed that this 1-kb fragment promotes higher reporter gene activity in MNDA-expressing cells than non-expressing cells, indicating cell-specific differences in transactivation.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "1-kb") (:form . "1-kb") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 69) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mnda-expressing") (:form . "MNDA-expressing")\n  (:end . 111) (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-expressing") (:form . "non-expressing")\n  (:end . 137) (:start . 123) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 169) (:start . 156) (:id . 63))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 181)\n  (:start . 170) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 200) (:start . 185) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1014.5) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009471@unknown@formal@none@1@S@This sequence contains consensus elements consistent with myeloid-specific gene expression, including a PU.1 consensus site near the major transcription start site and a cluster of c-Myb sites located several hundred bases upstream of this region.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 74) (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 101)\n  (:start . 92) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 108) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 118)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 123) (:start . 119)\n  (:id . 57))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 158)\n  (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 163) (:start . 159)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 177)\n  (:start . 170) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 186)\n  (:start . 181) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 192)\n  (:start . 187) (:id . 69))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 200)\n  (:start . 193) (:id . 70))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 208)\n  (:start . 201) (:id . 71))\n ((:tag . "CD") (:stem . "hundred") (:form . "hundred") (:end . 216)\n  (:start . 209) (:id . 72))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 222)\n  (:start . 217) (:id . 73))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 231)\n  (:start . 223) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 234) (:start . 232)\n  (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 239) (:start . 235)\n  (:id . 76))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 246)\n  (:start . 240) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1014.6) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009472@unknown@formal@none@1@S@However, analysis of deletion mutants localized nearly all of the promoter activity to a short region (-73 to -16) that did not include the cluster of c-Myb sites.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "CD") (:stem . "-73") (:form . "-73") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-16") (:form . "-16") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 66))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 135)\n  (:start . 128) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 147)\n  (:start . 140) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 156)\n  (:start . 151) (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 162)\n  (:start . 157) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1014.7.1) (:span 124 127)))\n (:nscopes ((:id . :x1014.7.1) (:span 124 162)))\n (:identifiers (:sid . :s1014.7) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009473@unknown@formal@none@1@S@A 4-bp mutation of the core Sp1 consensus element (GC box) (-20) reduced overall promoter activity of the 1-kb fragment.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "4-bp") (:form . "4-bp") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-20") (:form . "-20") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 72)\n  (:start . 65) (:id . 58))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 80)\n  (:start . 73) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 89)\n  (:start . 81) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 98)\n  (:start . 90) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "1-kb") (:form . "1-kb") (:end . 110) (:start . 106)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 119)\n  (:start . 111) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1014.8) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009474@unknown@formal@none@1@S@Mutation of the PU.1 site did not significantly affect promoter activity.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1014.9) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009475@unknown@formal@none@1@S@Only a small region (-35 to +22) including the Sp1 element and transcription start site, but not the PU.1 site was footprinted.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "CD") (:stem . "-35") (:form . "-35") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "CD") (:stem . "+22") (:form . "+22") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 42)\n  (:start . 33) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 50) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 58)\n  (:start . 51) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 56))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 105) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 110) (:start . 106)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "footprinte") (:form . "footprinted") (:end . 126)\n  (:start . 115) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1014.10.1) (:span 93 96)))\n (:nscopes ((:id . :x1014.10.1) (:span 93 110)))\n (:identifiers (:sid . :s1014.10) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009476@unknown@formal@none@1@S@The 4-bp mutation of the core Sp1 consensus element abolished footprinting at the site and an antibody super-shift reaction showed that Sp1 is one of the factors binding the consensus site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "4-bp") (:form . "4-bp") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "JJ") (:stem . "super-shift") (:form . "super-shift") (:end . 114)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 183)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1014.11) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009477@unknown@formal@none@1@S@The Sp1 site also co-localizes with a DNase I hypersensitive site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "co-localize") (:form . "co-localizes") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 60) (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1014.12) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009478@unknown@formal@none@1@S@The results indicate that DNA methylation, chromatin structure, and transactivation at an Sp1 site contribute to the highly restricted expression of this myelomonocytic lineage specific gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "methylation") (:form . "methylation") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 83) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 168) (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 176)\n  (:start . 169) (:id . 67))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 185)\n  (:start . 177) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 190) (:start . 186)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1014.13.1) (:span 12 25)))\n (:hscopes ((:id . :x1014.13.1) (:span 12 190)))\n (:identifiers (:sid . :s1014.13) (:did . :|9136080|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009480@unknown@formal@none@1@S@The expression of major histocompatibility complex (MHC) class II antigens is constitutive in professional antigen presenting cells (APCs) but can also be induced by interferon-gamma (IFN-gamma) on the majority of the non professional APCs (e.g. fibroblasts).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 42) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 90)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "professional") (:form . "professional") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "presenting") (:form . "presenting") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "NNPS") (:stem . "APC") (:form . "APCs") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 182) (:start . 166) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 193)\n  (:start . 184) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 210)\n  (:start . 202) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "non") (:form . "non") (:end . 221) (:start . 218)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "professional") (:form . "professional") (:end . 234)\n  (:start . 222) (:id . 80))\n ((:tag . "NNS") (:stem . "apc") (:form . "APCs") (:end . 239) (:start . 235)\n  (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 241) (:start . 240)\n  (:id . 82))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 245) (:start . 241)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 257)\n  (:start . 246) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 258) (:start . 257)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1015.2) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009481@unknown@formal@none@1@S@We have recently characterised a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "characterise") (:form . "characterised")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 50) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IK") (:form . "IK") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1015.3) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009482@unknown@formal@none@1@S@Here, we demonstrate a novel role for IK in MHC class II expression since over-expression of this protein by stable transfection into human B cells led to a total disappearance of constitutive MHC class II mRNA expression.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IK") (:form . "IK") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 47) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 55))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "over-expression") (:form . "over-expression")\n  (:end . 89) (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 128)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 162)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "disappearance") (:form . "disappearance")\n  (:end . 176) (:start . 163) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 192)\n  (:start . 180) (:id . 74))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 202)\n  (:start . 197) (:id . 76))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 205) (:start . 203)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 210) (:start . 206)\n  (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1015.4) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009483@unknown@formal@none@1@S@The class II transactivator (CIITA) is necessary for both constitutive and IFN-gamma induced MHC class II expressions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "expression") (:form . "expressions") (:end . 117)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1015.5) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009484@unknown@formal@none@1@S@Examination of CIITA mRNA in IK stably transfected clones revealed a marked reduction of CIITA mRNA transcription.@(((:tag . "NNP") (:stem . "Examination") (:form . "Examination") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IK") (:form . "IK") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 113) (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1015.6) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009485@unknown@formal@none@1@S@Taken together these results demonstrate that the IK protein plays a key role in the constitutive expression of MHC class II antigens and that inhibition induced by IK is upstream of CIITA in this regulatory pathway.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IK") (:form . "IK") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 97)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IK") (:form . "IK") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 188)\n  (:start . 183) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 196) (:start . 192)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 207)\n  (:start . 197) (:id . 76))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 215)\n  (:start . 208) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1015.7) (:did . :|9136989|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009486@unknown@formal@none@1@S@An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "enhancer-blocking") (:form . "enhancer-blocking")\n  (:end . 20) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "alpha/delta") (:form . "alpha/delta") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1016.1) (:did . :|9144218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009487@unknown@formal@none@1@S@T cell receptor (TCR) alpha and delta gene segments are organized within a single genetic locus but are differentially regulated during T cell development.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 27) (:start . 22)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "organize") (:form . "organized") (:end . 65)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 118) (:start . 104) (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 154)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1016.2) (:did . :|9144218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009488@unknown@formal@none@1@S@An enhancer-blocking element (BEAD-1, for blocking element alpha/delta 1) was localized to a 2.0-kb region 3' of TCR delta gene segments and 5' of TCR alpha joining gene segments within this locus.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "enhancer-blocking") (:form . "enhancer-blocking")\n  (:end . 20) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BEAD-1") (:form . "BEAD-1") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "alpha/delta") (:form . "alpha/delta") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "2.0-kb") (:form . "2.0-kb") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 143) (:start . 142)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 150) (:start . 147)\n  (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 156)\n  (:start . 151) (:id . 72))\n ((:tag . "NN") (:stem . "joining") (:form . "joining") (:end . 164)\n  (:start . 157) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 169) (:start . 165)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 178)\n  (:start . 170) (:id . 75))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 185)\n  (:start . 179) (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 190) (:start . 186)\n  (:id . 77))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 196)\n  (:start . 191) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1016.3) (:did . :|9144218|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009490@unknown@formal@none@1@S@We propose that BEAD-1 functions as a boundary that separates the TCR alpha/delta locus into distinct regulatory domains controlled by Edelta and the TCR alpha enhancer, and that it prevents Edelta from opening the chromatin of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell development.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bead-1") (:form . "BEAD-1") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "separate") (:form . "separates") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha/delta") (:form . "alpha/delta") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . 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5009491@unknown@formal@none@1@S@Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: lack of correspondence with common allelic variants.@(((:tag . "NN") (:stem . "quantification") (:form . "Quantification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "correspondence") (:form . "correspondence")\n  (:end . 114) (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "allelic") (:form . "allelic") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1017.1.1) (:span 92 96)))\n (:nscopes ((:id . :x1017.1.1) (:span 92 143)))\n (:identifiers (:sid . :s1017.1) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009492@unknown@formal@none@1@S@It has been recently claimed that polymorphism for the vitamin D receptor (VDR) influences several aspects of calcium and bone metabolism.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "claim") (:form . "claimed") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1017.2) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009493@unknown@formal@none@1@S@To evaluate the physiologic plausibility of these claims, we compared the abundance of the VDR mRNA in peripheral blood mononuclear cells (PBMCs) between different VDR genotypes using a quantitative reverse transcribed polymerase chain reaction-based method.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "plausibility") (:form . "plausibility") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "claim") (:form . "claims") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMCs") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 153)\n  (:start . 146) (:id . 67))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 163)\n  (:start . 154) (:id . 68))\n ((:tag . "NN") (:stem . "vdr") (:form . "VDR") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "genotype") (:form . "genotypes") (:end . 177)\n  (:start . 168) (:id . 70))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 183) (:start . 178)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "quantitative") (:form . "quantitative") (:end . 198)\n  (:start . 186) (:id . 73))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 206)\n  (:start . 199) (:id . 74))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 218)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 229)\n  (:start . 219) (:id . 76))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 235)\n  (:start . 230) (:id . 77))\n ((:tag . "JJ") (:stem . "reaction-based") (:form . "reaction-based")\n  (:end . 250) (:start . 236) (:id . 78))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 257)\n  (:start . 251) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1017.3) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009494@unknown@formal@none@1@S@The method is based on the coamplification of VDR cDNA and an internal standard consisting of known concentrations of a human VDR CDNA mutated at a BglII restriction site; the interassay coefficient of variation is 11%.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "coamplification") (:form . "coamplification")\n  (:end . 42) (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "standard") (:form . "standard") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 114) (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cdna") (:form . "CDNA") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "BglII") (:form . "BglII") (:end . 153)\n  (:start . 148) (:id . 68))\n ((:tag . "NN") (:stem . "restriction") (:form . "restriction") (:end . 165)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "interassay") (:form . "interassay") (:end . 186)\n  (:start . 176) (:id . 73))\n ((:tag . "NN") (:stem . "coefficient") (:form . "coefficient") (:end . 198)\n  (:start . 187) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 75))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 217) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 218) (:start . 217)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1017.4) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009495@unknown@formal@none@1@S@To validate the method, we made use of earlier receptor binding studies indicating that normal human monocytes and activated, but not resting, lymphocytes expressed the VDR.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "validate") (:form . "validate") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "make") (:form . "made") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 154)\n  (:start . 143) (:id . 67))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 164)\n  (:start . 155) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "vdr") (:form . "VDR") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1017.5.2) (:span 72 87)))\n (:ncues ((:id . :x1017.5.1) (:span 130 133)))\n (:hscopes ((:id . :x1017.5.2) (:span 72 172)))\n (:nscopes ((:id . :x1017.5.1) (:span 130 141)))\n (:identifiers (:sid . :s1017.5) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009496@unknown@formal@none@1@S@The concentration of the VDR mRNA was 10(-8) to 10(-7) g/g of total RNA in cell-sorted monocytes and in in vitro activated lymphocytes, but only 10(-12) g/g of total mRNA in resting lymphocytes, establishing that the VDR mRNA determined by our method in PBMCs is due to constitutive expression in monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . 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5009498@unknown@formal@none@1@S@The concentration of the VDR mRNA, corrected for the number of monocytes, was similar among the three genotype groups, as were the other variables examined: serum calcitriol, serum osteocalcin, and vertebral and hip bone density.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "correct") (:form . "corrected") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 101) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "genotype") (:form . "genotype") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 136)\n  (:start . 131) (:id . 67))\n ((:tag . "NNS") (:stem . "variable") (:form . "variables") (:end . 146)\n  (:start . 137) (:id . 68))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 155)\n  (:start . 147) (:id . 69))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 162)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "calcitriol") (:form . "calcitriol") (:end . 173)\n  (:start . 163) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 180)\n  (:start . 175) (:id . 74))\n ((:tag . "NN") (:stem . "osteocalcin") (:form . "osteocalcin") (:end . 192)\n  (:start . 181) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "vertebral") (:form . "vertebral") (:end . 207)\n  (:start . 198) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 79))\n ((:tag . "NN") (:stem . "hip") (:form . "hip") (:end . 215) (:start . 212)\n  (:id . 80))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 220) (:start . 216)\n  (:id . 81))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 228)\n  (:start . 221) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1017.8) (:did . :|9144338|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009500@unknown@formal@none@1@S@Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 58)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1018.1) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009501@unknown@formal@none@1@S@Stimulation of mature peripheral T cells by TCR engagement results in activation of signals that drive induction of cytokine gene expression and clonal expansion.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "drive") (:form . "drive") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 151)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1018.2) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009502@unknown@formal@none@1@S@However, under some conditions, engagement of the TCR leads instead to apoptosis.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1018.3) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009503@unknown@formal@none@1@S@Recent studies demonstrate that TCR-stimulated apoptosis requires expression of CD95 ligand on activated T cells followed by an interaction between CD95 ligand and the CD95 receptor also expressed on this population.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tcr-stimulated") (:form . "TCR-stimulated")\n  (:end . 46) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 56)\n  (:start . 47) (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd95") (:form . "CD95") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 91)\n  (:start . 85) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 139)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 147)\n  (:start . 140) (:id . 61))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 159)\n  (:start . 153) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 181)\n  (:start . 173) (:id . 67))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 186) (:start . 182)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 204) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 215)\n  (:start . 205) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1018.4) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009504@unknown@formal@none@1@S@The experiments reported in this study were designed to address the signaling events triggered by TCR engagement that are important for regulating CD95 ligand gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "cd95") (:form . "CD95") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1018.5) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009505@unknown@formal@none@1@S@To approach this, we generated a luciferase reporter construct containing elements of the CD95 ligand promoter.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "approach") (:form . "approach") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1018.6) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009506@unknown@formal@none@1@S@Using a previously described mutant of the Jurkat T cell line, we show that proximal signaling events dependent on the presence of the CD45 tyrosine phosphatase are required for TCR-stimulated CD95 ligand expression.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 160)\n  (:start . 149) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "tcr-stimulated") (:form . "TCR-stimulated")\n  (:end . 192) (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "cd95") (:form . "CD95") (:end . 197) (:start . 193)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 204)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 215)\n  (:start . 205) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1018.7) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009507@unknown@formal@none@1@S@Transient transfection studies demonstrate further that TCR-stimulated activation of the Ras signaling pathway is required for optimal activation of CD95 ligand.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 42)\n  (:start . 31) (:id . 45))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 50)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tcr-stimulated") (:form . "TCR-stimulated")\n  (:end . 70) (:start . 56) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "Ras") (:form . "Ras") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 102)\n  (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 110)\n  (:start . 103) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 122)\n  (:start . 114) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 134)\n  (:start . 127) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 153) (:start . 149)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 160)\n  (:start . 154) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1018.8) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009508@unknown@formal@none@1@S@Next, in an effort to determine critical transcription factors that regulate CD95 ligand expression, we demonstrate a cyclosporin A-sensitive nuclear factor-AT response element in the promoter region of this gene that is critical for optimal CD95 ligand reporter activity in stimulated T cells.@(((:tag . "RB") (:stem . "next") (:form . "Next") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effort") (:form . "effort") (:end . 18)\n  (:start . 12) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 129)\n  (:start . 118) (:id . 61))\n ((:tag . "JJ") (:stem . "a-sensitive") (:form . "A-sensitive") (:end . 141)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "NN") (:stem . "factor-at") (:form . "factor-AT") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 168)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 176)\n  (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 192)\n  (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 199)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 212) (:start . 208)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 217) (:start . 213)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 220) (:start . 218)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 229)\n  (:start . 221) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 233) (:start . 230)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 241)\n  (:start . 234) (:id . 78))\n ((:tag . "NN") (:stem . "cd95") (:form . "CD95") (:end . 246) (:start . 242)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 253)\n  (:start . 247) (:id . 80))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 262)\n  (:start . 254) (:id . 81))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 271)\n  (:start . 263) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 274) (:start . 272)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 285)\n  (:start . 275) (:id . 84))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 287) (:start . 286)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 293)\n  (:start . 288) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 294) (:start . 293)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1018.9) (:did . :|9144472|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009510@unknown@formal@none@1@S@CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "b7-independent") (:form . "B7-independent")\n  (:end . 58) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 121)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1019.1) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009511@unknown@formal@none@1@S@CD40 is an important signaling and activation Ag found on certain bone marrow-derived cells.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "marrow-derived") (:form . "marrow-derived")\n  (:end . 85) (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1019.2) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009512@unknown@formal@none@1@S@Recently, CD40 also has been shown to be expressed by mesenchymal cells, including human fibroblasts.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mesenchymal") (:form . "mesenchymal") (:end . 65)\n  (:start . 54) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 100)\n  (:start . 89) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1019.3) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009513@unknown@formal@none@1@S@Little is known about the role of CD40 in fibroblasts.@(((:tag . "JJ") (:stem . "little") (:form . "Little") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 53)\n  (:start . 42) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1019.4) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009514@unknown@formal@none@1@S@The current study investigates the hypothesis that CD40 expressed on lung fibroblasts is an activation structure and mechanism for interaction with hemopoietic cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "investigate") (:form . "investigates") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 126)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 142)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hemopoietic") (:form . "hemopoietic") (:end . 159)\n  (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1019.5.1) (:span 35 45)))\n (:hscopes ((:id . :x1019.5.1) (:span 35 165)))\n (:identifiers (:sid . :s1019.5) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009515@unknown@formal@none@1@S@Communication between resident tissue fibroblasts and T cells is necessary for normal wound healing, and can be pathologic, resulting in tissue fibrosis.@(((:tag . "NNP") (:stem . "Communication") (:form . "Communication")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "JJ") (:stem . "resident") (:form . "resident") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 49)\n  (:start . 38) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "NN") (:stem . "wound") (:form . "wound") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "healing") (:form . "healing") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pathologic") (:form . "pathologic") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1019.6) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009516@unknown@formal@none@1@S@Signaling through CD40 with soluble CD40 ligand stimulated fibroblast activation, as evidenced by mobilization of nuclear factor-kappaB and by induction of the proinflammatory and chemoattractant cytokines IL-6 and IL-8.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 110)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 135) (:start . 122) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 152)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 175) (:start . 160) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 195) (:start . 180) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 205)\n  (:start . 196) (:id . 68))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 210) (:start . 206)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 219) (:start . 215)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1019.7) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009517@unknown@formal@none@1@S@IFN-gamma-primed lung fibroblasts costimulate T lymphocyte proliferation utilizing CD40, but not the well-studied costimulatory molecules B7-1 and B7-2.@(((:tag . "JJ") (:stem . "ifn-gamma-primed") (:form . "IFN-gamma-primed")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 21) (:start . 17)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 33)\n  (:start . 22) (:id . 44))\n ((:tag . "VBP") (:stem . "costimulate") (:form . "costimulate") (:end . 45)\n  (:start . 34) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 58)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 72) (:start . 59) (:id . 48))\n ((:tag . "VBG") (:stem . "utilize") (:form . "utilizing") (:end . 82)\n  (:start . 73) (:id . 49))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 87) (:start . 83)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "well-studied") (:form . "well-studied") (:end . 113)\n  (:start . 101) (:id . 55))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 127) (:start . 114) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 137)\n  (:start . 128) (:id . 57))\n ((:tag . "NN") (:stem . "b7-1") (:form . "B7-1") (:end . 142) (:start . 138)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 59))\n ((:tag . "NN") (:stem . "b7-2") (:form . "B7-2") (:end . 151) (:start . 147)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1019.8.1) (:span 93 96)))\n (:nscopes ((:id . :x1019.8.1) (:span 93 151)))\n (:identifiers (:sid . :s1019.8) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009518@unknown@formal@none@1@S@Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types.@(((:tag . "NNP") (:stem . "Datum") (:form . "Data") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "herein") (:form . "herein") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 84)\n  (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 96)\n  (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "infiltrate") (:form . "infiltrating") (:end . 113)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 127)\n  (:start . 116) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 58))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CD40/CD40L") (:form . "CD40/CD40L") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 155)\n  (:start . 148) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "NN") (:stem . "augment") (:form . "augment") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 177)\n  (:start . 165) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 185) (:start . 182)\n  (:id . 67))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 193)\n  (:start . 186) (:id . 68))\n ((:tag . "NN") (:stem . "fibrogenesis") (:form . "fibrogenesis") (:end . 206)\n  (:start . 194) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 209) (:start . 207)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 220)\n  (:start . 210) (:id . 71))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 225) (:start . 221)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 230) (:start . 226)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 236)\n  (:start . 231) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1019.9.1) (:span 182 185))\n  ((:id . :x1019.9.2) (:span 33 43)))\n (:hscopes ((:id . :x1019.9.1) (:span 182 236))\n  ((:id . :x1019.9.2) (:span 33 236)))\n (:identifiers (:sid . :s1019.9) (:did . :|9144479|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009520@unknown@formal@none@1@S@Triggering of HLA class II antigens by the anti-HLA-DR monoclonal antibody (mAb) L243 significantly (P < 0.05) and differentially enhanced the release of tumor necrosis factor alpha (TNF-alpha) by the non-Hodgkin's lymphoma cells Ri-I, Ci-I, and Sc-I, which are at a distinct stage of B-cell differentiation, and by the more mature Burkitt lymphoma cell Raji; in contrast, it did not induce TNF-alpha release by the pre-B leukemia cells Nalm-6 and BV173.@(((:tag . "NN") (:stem . "triggering") (:form . "Triggering") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HLA") (:form . "HLA") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "antigen") (:form . 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"release") (:end . 408)\n  (:start . 401) (:id . 117))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 411) (:start . 409)\n  (:id . 118))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 415) (:start . 412)\n  (:id . 119))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 421)\n  (:start . 416) (:id . 120))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 430)\n  (:start . 422) (:id . 121))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 436)\n  (:start . 431) (:id . 122))\n ((:tag . "NNP") (:stem . "Nalm-6") (:form . "Nalm-6") (:end . 443)\n  (:start . 437) (:id . 123))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 447) (:start . 444)\n  (:id . 124))\n ((:tag . "NNP") (:stem . "BV173") (:form . "BV173") (:end . 453)\n  (:start . 448) (:id . 125))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5009521@unknown@formal@none@1@S@TNF-alpha release peaked at 24 h and decreased thereafter, and it was dose dependent and preceded by an increase of TNF-alpha mRNA detectable after 3 h of stimulation with mAb L243.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "peak") (:form . "peaked") (:end . 24) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "thereafter") (:form . "thereafter") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "precede") (:form . "preceded") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 141)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 166)\n  (:start . 155) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "NN") (:stem . "l243") (:form . "L243") (:end . 180) (:start . 176)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1020.3) (:did . :|9149909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009522@unknown@formal@none@1@S@Secreted TNF-alpha mediated the enhancement of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding activity; in fact, the triggering of HLA-DR antigens in the presence of antihuman TNF-alpha-neutralizing antibodies did not upregulate NF-kappa B and AP-1.@(((:tag . "VBN") (:stem . "secrete") (:form . "Secreted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 155)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 174)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 190)\n  (:start . 182) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "antihuman") (:form . "antihuman") (:end . 203)\n  (:start . 194) (:id . 77))\n ((:tag . "JJ") (:stem . "tnf-alpha-neutralizing")\n  (:form . "TNF-alpha-neutralizing") (:end . 226) (:start . 204) (:id . 78))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 237)\n  (:start . 227) (:id . 79))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 241) (:start . 238)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 245) (:start . 242)\n  (:id . 81))\n ((:tag . "VB") (:stem . "upregulate") (:form . "upregulate") (:end . 256)\n  (:start . 246) (:id . 82))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 265)\n  (:start . 257) (:id . 83))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 267) (:start . 266)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 271) (:start . 268)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 276) (:start . 272)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x1020.4.1) (:span 242 245)))\n (:nscopes ((:id . :x1020.4.1) (:span 242 276)))\n (:identifiers (:sid . :s1020.4) (:did . :|9149909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009523@unknown@formal@none@1@S@In contrast, released TNF-alpha was not responsible for the homotypic aggregation of Ri-I, Ci-I, Sc-I, and Raji cells induced by mAb L243, and it did not affect the proliferation of B cells investigated.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "homotypic") (:form . "homotypic") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ri-I") (:form . "Ri-I") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ci-I") (:form . "Ci-I") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Sc-I") (:form . "Sc-I") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 125)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "l243") (:form . "L243") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 69))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 145) (:start . 143)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 149) (:start . 146)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 153) (:start . 150)\n  (:id . 72))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 160)\n  (:start . 154) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 74))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 178) (:start . 165) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 183) (:start . 182)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 189)\n  (:start . 184) (:id . 78))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 202)\n  (:start . 190) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x1020.5.1) (:span 150 153))\n  ((:id . :x1020.5.2) (:span 36 39)))\n (:nscopes ((:id . :x1020.5.1) (:span 150 202))\n  ((:id . :x1020.5.2) (:span 36 137)))\n (:identifiers (:sid . :s1020.5) (:did . :|9149909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009524@unknown@formal@none@1@S@Altogether, our data demonstrate that: (a) the ability of B cells to release TNF-alpha after triggering of HLA-DR antigens depends on their stage of differentiation; (b) levels of released TNF-alpha seem to correlate with the stage of B-cell maturation but do not correlate with the amounts of cell surface HLA-DR antigens; (c) secreted TNF-alpha regulates the levels of expression of NF-kappa B and AP-1 by an autocrine loop; and (d) intracellular signals mediating TNF-alpha release by B cells are distinct from those regulating homotypic aggregation and proliferation.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . 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5009525@unknown@formal@none@1@S@Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.@(((:tag . "NNP") (:stem . "Cytomegalovirus") (:form . "Cytomegalovirus")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 25)\n  (:start . 16) (:id . 43))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 31) (:start . 26)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 37) (:start . 32)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "upregulate") (:form . "upregulate") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 62) (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1021.1) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009526@unknown@formal@none@1@S@BACKGROUND: The immediate early genes (IE) of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 67) (:start . 52) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 90)\n  (:start . 81) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 103)\n  (:start . 94) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 123)\n  (:start . 118) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 66))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 135)\n  (:start . 127) (:id . 67))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 141)\n  (:start . 136) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 154)\n  (:start . 146) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1021.2) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009527@unknown@formal@none@1@S@Interleukin-6 (IL-6) plays a central role in numerous inflammatory and immune processes.@(((:tag . "NNP") (:stem . "Interleukin-6") (:form . "Interleukin-6")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1021.3) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009528@unknown@formal@none@1@S@Interleukin-6 levels are increased in lung transplant patients clinically diagnosed with CMV pneumonitis.@(((:tag . "NNP") (:stem . "Interleukin-6") (:form . "Interleukin-6")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "VBN") (:stem . "diagnose") (:form . "diagnosed") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pneumonitis") (:form . "pneumonitis") (:end . 104)\n  (:start . 93) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1021.4) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009530@unknown@formal@none@1@S@These studies examined the ability of CMV IE gene products to modulate IL-6 production.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1021.6) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009531@unknown@formal@none@1@S@METHODS: THP-1 cells, a monocytic cell line, were transfected with the CMV IE genes.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 33)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 61)\n  (:start . 50) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1021.7) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009532@unknown@formal@none@1@S@Interleukin-6 protein and IL-6 mRNA were measured in control and CMV immediate early transfected cells.@(((:tag . "NNP") (:stem . "Interleukin-6") (:form . "Interleukin-6")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1021.8) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009533@unknown@formal@none@1@S@Cotransfection of CMV IE genes and IL-6 chloramphenicol acetyl transferase (CAT) or IL-6 luciferase constructs were used to study IL-6 promoter activity.@(((:tag . "NNP") (:stem . "Cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "transferase") (:form . "transferase") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1021.9) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009534@unknown@formal@none@1@S@RESULTS: Interleukin-6 protein and mRNA production were significantly increased in cells transfected with the CMV IE genes and stimulated with LPS compared to LPS-stimulated control cells.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "Interleukin-6")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 137)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 173) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 181)\n  (:start . 174) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1021.10) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009535@unknown@formal@none@1@S@Cytomegalovirus IE gene products significantly enhanced LPS stimulation of IL-6 promoter activity in both IL-6 CAT and IL-6 luciferase assays.@(((:tag . "NNP") (:stem . "Cytomegalovirus") (:form . "Cytomegalovirus")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IE") (:form . "IE") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 46) (:start . 33) (:id . 46))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 71)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1021.11) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009536@unknown@formal@none@1@S@A deletion construct that contains a NF-kappa B site but is missing the multiple response region demonstrated a continued increase in IL-6 luciferase activity in LPS-stimulated CMV transfected cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "continued") (:form . "continued") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 176) (:start . 162) (:id . 67))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "transfected") (:form . "transfected") (:end . 192)\n  (:start . 181) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 198)\n  (:start . 193) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x1021.12.1) (:span 60 67)))\n (:nscopes ((:id . :x1021.12.1) (:span 60 96)))\n (:identifiers (:sid . :s1021.12) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009537@unknown@formal@none@1@S@CONCLUSION: Cytomegalovirus immediate early gene products significantly enhanced expression of IL-6 in LPS-stimulated cells.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Cytomegalovirus") (:form . "Cytomegalovirus")\n  (:end . 27) (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 71) (:start . 58) (:id . 49))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 80)\n  (:start . 72) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 99) (:start . 95)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 117) (:start . 103) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1021.13) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009538@unknown@formal@none@1@S@The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 136)\n  (:start . 126) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 163)\n  (:start . 157) (:id . 71))\n ((:tag . "NN") (:stem . "amp") (:form . "amp") (:end . 167) (:start . 164)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 74))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 180)\n  (:start . 173) (:id . 75))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 193)\n  (:start . 181) (:id . 76))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 204)\n  (:start . 194) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x1021.14.1) (:span 55 62)))\n (:nscopes ((:id . :x1021.14.1) (:span 55 94)))\n (:identifiers (:sid . :s1021.14) (:did . :|9154298|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009540@unknown@formal@none@1@S@Cellular redox status influences both cytotoxic and NF-kappa B activation in natural killer cells.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "influence") (:form . "influences") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1022.1) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009541@unknown@formal@none@1@S@The role of cellular redox status in both cytotoxic activity and NF-kappa B activation in natural killer (NK) cells was investigated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 132)\n  (:start . 120) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1022.2) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009542@unknown@formal@none@1@S@The results indicate that stimulation of NK cells, either freshly isolated from peripheral blood lymphocytes (PBL) or long-term cultured NK clones, with specific cell targets results in an increased binding activity of NF-kappa B and AP-1 transcription factors measured by gel retardation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PBL") (:form . 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"cell") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 174)\n  (:start . 167) (:id . 70))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 198)\n  (:start . 189) (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 206)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 215)\n  (:start . 207) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 227)\n  (:start . 219) (:id . 78))\n ((:tag . "NNP") (:stem . "B") (:form . 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(:end . 289) (:start . 288)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x1022.3.1) (:span 12 25)))\n (:hscopes ((:id . :x1022.3.1) (:span 12 288)))\n (:identifiers (:sid . :s1022.3) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009543@unknown@formal@none@1@S@Pretreatment of NK cells with the antioxidant pyrrolidine dithiocarbarmate (PDTC) leads to the inhibition of NF-kappa B activation but the AP-1 binding to DNA was superinduced.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "dithiocarbarmate") (:form . "dithiocarbarmate")\n  (:end . 74) (:start . 58) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "superinduce") (:form . "superinduced") (:end . 175)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1022.4) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009544@unknown@formal@none@1@S@The inhibition of NF-kappa B by PDTC paralleled with an inhibition of spontaneous cytotoxicity mediated by NK cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "parallel") (:form . "paralleled") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "spontaneous") (:form . "spontaneous") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "cytotoxicity") (:form . "cytotoxicity") (:end . 94)\n  (:start . 82) (:id . 55))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1022.5) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009545@unknown@formal@none@1@S@Moreover, the inhibitors of serine proteases, N-alpha-tosyl-L-lysine chloromethyl ketone and N-alpha-tosyl-L-phenylalanine chloromethyl ketone, also blocked the cytolytic activity of NK cells against the sensitive target K562.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "N-alpha-tosyl-L-lysine")\n  (:form . "N-alpha-tosyl-L-lysine") (:end . 68) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "chloromethyl") (:form . "chloromethyl") (:end . 81)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "ketone") (:form . "ketone") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "n-alpha-tosyl-l-phenylalanine")\n  (:form . "N-alpha-tosyl-L-phenylalanine") (:end . 122) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chloromethyl") (:form . "chloromethyl") (:end . 135)\n  (:start . 123) (:id . 55))\n ((:tag . "NN") (:stem . "ketone") (:form . "ketone") (:end . 142)\n  (:start . 136) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 148) (:start . 144)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 156)\n  (:start . 149) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cytolytic") (:form . "cytolytic") (:end . 170)\n  (:start . 161) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 179)\n  (:start . 171) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 185) (:start . 183)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 65))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 199)\n  (:start . 192) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 213)\n  (:start . 204) (:id . 68))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 220)\n  (:start . 214) (:id . 69))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 225) (:start . 221)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1022.6) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009546@unknown@formal@none@1@S@In contrast, NK activity was not affected by pretreatment of the effector cells with the proteasome inhibitor N-acetyl-leu-leu-norleucinal which selectively inhibits NF-kappa B activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 57)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "N-acetyl-leu-leu-norleucinal")\n  (:form . "N-acetyl-leu-leu-norleucinal") (:end . 138) (:start . 110)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 156)\n  (:start . 145) (:id . 62))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 165)\n  (:start . 157) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 174)\n  (:start . 166) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 176) (:start . 175)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 187)\n  (:start . 177) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1022.7.1) (:span 29 32)))\n (:nscopes ((:id . :x1022.7.1) (:span 13 187)))\n (:identifiers (:sid . :s1022.7) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009547@unknown@formal@none@1@S@Altogether, these results support the hypothesis that the activation of NK cells involved transcriptional and post-transcriptional events, and that reactive intermediates may play an important role in the molecular processes related with the generation of a cytotoxic response by NK cells.@(((:tag . "RB") (:stem . "altogether") (:form . "Altogether") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "involve") (:form . "involved") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 105) (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "post-transcriptional")\n  (:form . "post-transcriptional") (:end . 130) (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 137)\n  (:start . 131) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 170) (:start . 157) (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 174) (:start . 171)\n  (:id . 65))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 182) (:start . 180)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 192)\n  (:start . 183) (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 197) (:start . 193)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 214)\n  (:start . 205) (:id . 72))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 224)\n  (:start . 215) (:id . 73))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 232)\n  (:start . 225) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 237) (:start . 233)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 76))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 252)\n  (:start . 242) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 255) (:start . 253)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 257) (:start . 256)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 267)\n  (:start . 258) (:id . 80))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 276)\n  (:start . 268) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 279) (:start . 277)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 282) (:start . 280)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 288)\n  (:start . 283) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x1022.8.1) (:span 171 174))\n  ((:id . :x1022.8.2) (:span 38 48)))\n (:hscopes ((:id . :x1022.8.1) (:span 171 288))\n  ((:id . :x1022.8.2) (:span 38 288)))\n (:identifiers (:sid . :s1022.8) (:did . :|9155655|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009548@unknown@formal@none@1@S@Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain.@(((:tag . "NN") (:stem . "homodimerization") (:form . "Homodimerization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 102)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1023.1.1) (:span 121 128)))\n (:nscopes ((:id . :x1023.1.1) (:span 121 170)))\n (:identifiers (:sid . :s1023.1) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009550@unknown@formal@none@1@S@The IL-4 receptor (IL-4R) in B cells is composed of two chains, the IL-4-binding IL-4Ralpha chain, which is shared with the IL-13R, and the IL-2Rgamma (gammac) chain, which is shared with IL-7R, IL-9R, and IL-15R.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 48)\n  (:start . 40) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 62)\n  (:start . 56) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "il-4-binding") (:form . "IL-4-binding") (:end . 80)\n  (:start . 68) (:id . 58))\n ((:tag . "NNP") (:stem . "IL-4Ralpha") (:form . "IL-4Ralpha") (:end . 91)\n  (:start . 81) (:id . 59))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 114)\n  (:start . 108) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 119) (:start . 115)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-13r") (:form . "IL-13R") (:end . 130)\n  (:start . 124) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "IL-2Rgamma") (:form . "IL-2Rgamma") (:end . 150)\n  (:start . 140) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 158)\n  (:start . 152) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 74))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 165)\n  (:start . 160) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 175) (:start . 173)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 182)\n  (:start . 176) (:id . 79))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 187) (:start . 183)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "IL-7R") (:form . "IL-7R") (:end . 193)\n  (:start . 188) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "IL-9R") (:form . "IL-9R") (:end . 200)\n  (:start . 195) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "IL-15R") (:form . "IL-15R") (:end . 212)\n  (:start . 206) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1023.3) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009551@unknown@formal@none@1@S@IL-4 induces Cepsilon germline transcripts and IgE isotype switching in B cells from patients with gammac chain deficiency.@(((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1023.4) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009552@unknown@formal@none@1@S@Induction of Cepsilon germline transcripts by IL-4 in B cells that lack the gammac chain may involve signaling via the IL-13R.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gammac") (:form . "gammac") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-13r") (:form . "IL-13R") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1023.5.1) (:span 89 92)))\n (:ncues ((:id . :x1023.5.2) (:span 67 71)))\n (:hscopes ((:id . :x1023.5.1) (:span 89 125)))\n (:nscopes ((:id . :x1023.5.2) (:span 67 88)))\n (:identifiers (:sid . :s1023.5) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009553@unknown@formal@none@1@S@Alternatively, the IL-4Ralpha chain may transduce intracellular signals that lead to Cepsilon gene transcription independently of its association with other chains.@(((:tag . "RB") (:stem . "alternatively") (:form . "Alternatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-4Ralpha") (:form . "IL-4Ralpha") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 56))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 126) (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 133) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 145)\n  (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 156)\n  (:start . 151) (:id . 62))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 163)\n  (:start . 157) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1023.6.1) (:span 36 39)))\n (:hscopes ((:id . :x1023.6.1) (:span 36 163)))\n (:identifiers (:sid . :s1023.6) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009554@unknown@formal@none@1@S@We show that ligand-induced homodimerization of chimeric surface receptors consisting of the extracellular and transmembrane domains of the erythropoietin receptor and of the intracellular domain of IL-4Ralpha induces Janus kinase 1 (Jak1) activation, STAT6 activation, and Cepsilon germline transcripts in human B cell line BJAB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ligand-induced") (:form . "ligand-induced")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "homodimerization") (:form . "homodimerization")\n  (:end . 44) (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "chimeric") (:form . 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"cell") (:end . 319) (:start . 315)\n  (:id . 88))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 324) (:start . 320)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "BJAB") (:form . "BJAB") (:end . 329) (:start . 325)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 330) (:start . 329)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s1023.7) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009555@unknown@formal@none@1@S@Disruption of the Jak1-binding proline-rich Box1 region of IL-4Ralpha abolished signaling by this chimeric receptor.@(((:tag . "NN") (:stem . "disruption") (:form . "Disruption") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "jak1-binding") (:form . "Jak1-binding") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "proline-rich") (:form . "proline-rich") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "box1") (:form . "Box1") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-4Ralpha") (:form . "IL-4Ralpha") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 115)\n  (:start . 107) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1023.8) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009556@unknown@formal@none@1@S@Furthermore, B cells transfected with a chimeric CD8alpha/IL-4Ralpha receptor, which is expressed on the cell surface as a homodimer, constitutively expressed Cepsilon germline transcripts.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "CD8alpha/IL-4Ralpha")\n  (:form . "CD8alpha/IL-4Ralpha") (:end . 68) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 148) (:start . 134) (:id . 64))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 176)\n  (:start . 168) (:id . 67))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 188)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1023.9) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009557@unknown@formal@none@1@S@These results suggest that homodimerization of the IL-4Ralpha chain is sufficient to transduce Jak1-dependent intracellular signals that lead to IgE isotype switching.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "homodimerization") (:form . "homodimerization")\n  (:end . 43) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-4Ralpha") (:form . "IL-4Ralpha") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "jak1-dependent") (:form . "Jak1-dependent")\n  (:end . 109) (:start . 95) (:id . 55))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 123) (:start . 110) (:id . 56))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 131)\n  (:start . 124) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 141) (:start . 137)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 156)\n  (:start . 149) (:id . 62))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 166)\n  (:start . 157) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1023.10.1) (:span 14 21)))\n (:hscopes ((:id . :x1023.10.1) (:span 14 166)))\n (:identifiers (:sid . :s1023.10) (:did . :|9159166|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009558@unknown@formal@none@1@S@Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 50) (:start . 37) (:id . 46))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 61)\n  (:start . 51) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 73)\n  (:start . 67) (:id . 49))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 77) (:start . 74)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 85)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 100)\n  (:start . 91) (:id . 53))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 117) (:start . 101) (:id . 54))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 128)\n  (:start . 118) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1024.1) (:did . :|9160887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009560@unknown@formal@none@1@S@This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tax1-induced") (:form . "Tax1-induced") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 108) (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 118)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1024.3) (:did . :|9160887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009561@unknown@formal@none@1@S@To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tax1-inducible") (:form . "Tax1-inducible")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 93) (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "introduce") (:form . "introduced") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "tax1") (:form . "Tax1") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "JJ") (:stem . "trans-activating") (:form . "trans-activating")\n  (:end . 153) (:start . 137) (:id . 61))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 164)\n  (:start . 154) (:id . 62))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 169) (:start . 165)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 180)\n  (:start . 170) (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 186)\n  (:start . 181) (:id . 65))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 198)\n  (:start . 187) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 200) (:start . 199)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 203) (:start . 200)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "retroviral") (:form . "retroviral") (:end . 218)\n  (:start . 208) (:id . 71))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 226)\n  (:start . 219) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1024.4) (:did . :|9160887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009562@unknown@formal@none@1@S@Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNPS") (:stem . "PBL") (:form . "PBLs") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1024.5) (:did . :|9160887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009563@unknown@formal@none@1@S@However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "expansion") (:form . "expansion") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 76) (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "SRF") (:form . "SRF") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 165)\n  (:start . 157) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1024.6) (:did . :|9160887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009564@unknown@formal@none@1@S@Involvement of the N-terminal region of the human mineralocorticoid receptor hormone-binding domain in agonist and antagonist binding as revealed by a new monoclonal antibody.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 67) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "JJ") (:stem . "hormone-binding") (:form . "hormone-binding")\n  (:end . 92) (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 99)\n  (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 54))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 125)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 133)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 145)\n  (:start . 137) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1025.1) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009565@unknown@formal@none@1@S@To gain a better understanding of the mechanism of binding to the human mineralocorticoid receptor (hMR), we developed a new monoclonal antibody (mAb) raised against the hormone-binding domain (HBD).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 16) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mineralocorticoid") (:form . "mineralocorticoid")\n  (:end . 89) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "hMR") (:form . "hMR") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 135)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 157)\n  (:start . 151) (:id . 70))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 165)\n  (:start . 158) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "hormone-binding") (:form . "hormone-binding")\n  (:end . 185) (:start . 170) (:id . 73))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 192)\n  (:start . 186) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HBD") (:form . "HBD") (:end . 197) (:start . 194)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 198) (:start . 197)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1025.2) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009566@unknown@formal@none@1@S@For this purpose, mice were immunized with a fusion protein including the sequence Thr729-Lys984 of hMR.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "immunize") (:form . "immunized") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "thr729-lys984") (:form . "Thr729-Lys984")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "hMR") (:form . "hMR") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1025.3) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009567@unknown@formal@none@1@S@After ELISA screening, mAb 18C7 was selected for its specificity towards the HBD.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "screening") (:form . "screening") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HBD") (:form . "HBD") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1025.4) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009568@unknown@formal@none@1@S@This antibody recognized both the denatured and native MR forms, as well as the hetero-oligomeric MR form and the transformed MR state.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "recognize") (:form . "recognized") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "denature") (:form . "denatured") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "mr") (:form . "MR") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hetero-oligomeric") (:form . "hetero-oligomeric")\n  (:end . 97) (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "mr") (:form . "MR") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 125)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "mr") (:form . "MR") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1025.5) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009570@unknown@formal@none@1@S@We then studied the effect of the antibody on aldosterone and progesterone binding to the hMR.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "hMR") (:form . "hMR") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1025.7) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009571@unknown@formal@none@1@S@When 18C7 was incubated with liganded MR, it was able to partly displace (20%) the hormone from its binding site.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "liganded") (:form . "liganded") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "mr") (:form . "MR") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "VB") (:stem . "displace") (:form . "displace") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 90)\n  (:start . 83) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 99) (:start . 96)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 64))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1025.8) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009572@unknown@formal@none@1@S@When 18C7 was incubated with MR before aldosterone or progesterone, the antibody inhibited 75-80% of the binding.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mr") (:form . "MR") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "CD") (:stem . "75-80") (:form . "75-80") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1025.9) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009573@unknown@formal@none@1@S@The effect of 18C7 on the binding was similar with both hormones.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1025.10) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009574@unknown@formal@none@1@S@A sucrose gradient analysis indicated the simultaneous presence of two kinds of receptor complexes: the steroid-MR complex and the antibody-MR complex.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sucrose") (:form . "sucrose") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "gradient") (:form . "gradient") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "kind") (:form . "kinds") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "steroid-MR") (:form . "steroid-MR") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "antibody-mr") (:form . "antibody-MR") (:end . 142)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1025.11) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009575@unknown@formal@none@1@S@After its associated proteins, especially the heat-shock protein hsp90, had been cross-linked with the hMR by dimethylpimelimidate, 18C7 was still able to react with the receptor.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "heat-shock") (:form . "heat-shock") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "hsp90") (:form . "hsp90") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cross-linked") (:form . "cross-linked") (:end . 93)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "hMR") (:form . "hMR") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dimethylpimelimidate")\n  (:form . "dimethylpimelimidate") (:end . 130) (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "VB") (:stem . "react") (:form . "react") (:end . 160)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1025.12) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009576@unknown@formal@none@1@S@Our results indicated that the epitope recognized by 18C7 was directly implicated in hormone binding.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "18c7") (:form . "18C7") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1025.13.1) (:span 12 26)))\n (:hscopes ((:id . :x1025.13.1) (:span 12 100)))\n (:identifiers (:sid . :s1025.13) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009577@unknown@formal@none@1@S@The lack of steroid binding of HBD mutants with the Thr729-Leu765 sequence deleted [Jalaguier, Mesnier, Leger and Auzou (1996) J.Steroid Biochem.Mol.Biol.57, 43-50] supports this hypothesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hbd") (:form . "HBD") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "thr729-leu765") (:form . "Thr729-Leu765")\n  (:end . 65) (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Jalaguier") (:form . "Jalaguier") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Mesnier") (:form . "Mesnier") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Leger") (:form . "Leger") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Auzou") (:form . "Auzou") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1996") (:form . "1996") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "J.Steroid") (:form . "J.Steroid") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . "NNP") (:stem . "Biochem.Mol.Biol.57")\n  (:form . "Biochem.Mol.Biol.57") (:end . 156) (:start . 137) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "CD") (:stem . "43-50") (:form . "43-50") (:end . 163)\n  (:start . 158) (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 164) (:start . 163)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 173)\n  (:start . 165) (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 178) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 189)\n  (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1025.14.1) (:span 4 8)))\n (:nscopes ((:id . :x1025.14.1) (:span 4 82)))\n (:identifiers (:sid . :s1025.14) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009578@unknown@formal@none@1@S@Because of the similar behaviours of aldosterone and progesterone, we conclude that the N-terminal Thr729-Leu765 region of the HBD is similarly involved in the binding of both hormones.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "behaviour") (:form . "behaviours") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "aldosterone") (:form . "aldosterone") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "Thr729-Leu765") (:form . "Thr729-Leu765")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HBD") (:form . "HBD") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1025.15) (:did . :|9164841|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009580@unknown@formal@none@1@S@A role in thymic maturation for factors of the NF-kappaB family has long been suspected, but not yet proven.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "suspect") (:form . "suspected") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "prove") (:form . "proven") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1026.2.2) (:span 78 87)))\n (:ncues ((:id . :x1026.2.1) (:span 93 96)))\n (:hscopes ((:id . :x1026.2.2) (:span 0 87)))\n (:nscopes ((:id . :x1026.2.1) (:span 93 107)))\n (:identifiers (:sid . :s1026.2) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009581@unknown@formal@none@1@S@Transgenic mice with a lymphocyte-specific defect in NF-kappaB activation were produced by targeted expression of human IkappaB alpha.@(((:tag . "JJ") (:stem . "transgenic") (:form . "Transgenic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 42) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 110)\n  (:start . 100) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1026.3) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009582@unknown@formal@none@1@S@The thymic cellularity of these mice was significantly decreased.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cellularity") (:form . "cellularity") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1026.4) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009583@unknown@formal@none@1@S@The proportion of mature, TCRhigh thymocytes of the alphabeta lineage was reduced, and the remaining TCRhigh population contained an unusually high proportion of double-positive cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tcrhigh") (:form . "TCRhigh") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alphabeta") (:form . "alphabeta") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "tcrhigh") (:form . "TCRhigh") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "RB") (:stem . "unusually") (:form . "unusually") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "double-positive") (:form . "double-positive")\n  (:end . 177) (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 183)\n  (:start . 178) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1026.5) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009584@unknown@formal@none@1@S@This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd8") (:form . "CD8") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 130) (:start . 125)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1026.6) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009585@unknown@formal@none@1@S@These data provide direct evidence for the involvement of NF-kappaB/Rel family proteins in late stages of T lymphocyte development, coincident with positive and negative selection.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 102)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 130)\n  (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "coincident") (:form . "coincident") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 169)\n  (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 179)\n  (:start . 170) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1026.7) (:did . :|9164919|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009586@unknown@formal@none@1@S@Sequential development of structural and functional alterations in T cells from tumor-bearing mice.@(((:tag . "JJ") (:stem . "sequential") (:form . "Sequential") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tumor-bearing") (:form . "tumor-bearing")\n  (:end . 93) (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1027.1) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009587@unknown@formal@none@1@S@The TCR alpha beta or -gamma delta chains bind the peptide ligand, whereas the associated CD3 delta epsilon gamma and TCR zeta subunits couple the TCR to intracellular signal transduction components.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "-gamma") (:form . "-gamma") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 135)\n  (:start . 127) (:id . 65))\n ((:tag . "VBP") (:stem . "couple") (:form . "couple") (:end . 142)\n  (:start . 136) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 167) (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 174)\n  (:start . 168) (:id . 71))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 187)\n  (:start . 175) (:id . 72))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 198)\n  (:start . 188) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1027.2) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009588@unknown@formal@none@1@S@Recently, several groups have described marked alterations in signal transduction elements in T cells from cancer patients or in mice bearing tumor for a few weeks (>26 days).@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 81)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 133)\n  (:start . 129) (:id . 62))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "week") (:form . "weeks") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "CD") (:stem . ">26") (:form . ">26") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 173) (:start . 169)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1027.3) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009590@unknown@formal@none@1@S@The aim of this study was to explore the kinetics of the development of alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck)) in mice bearing MC38 colon adenocarcinoma.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 68)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 83)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 106)\n  (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 173)\n  (:start . 165) (:id . 72))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 180)\n  (:start . 174) (:id . 73))\n ((:tag . "NN") (:stem . "p56(lck))") (:form . "p56(lck))") (:end . 190)\n  (:start . 181) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 198)\n  (:start . 194) (:id . 76))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 206)\n  (:start . 199) (:id . 77))\n ((:tag . "NN") (:stem . "mc38") (:form . "MC38") (:end . 211) (:start . 207)\n  (:id . 78))\n ((:tag . "NN") (:stem . "colon") (:form . "colon") (:end . 217)\n  (:start . 212) (:id . 79))\n ((:tag . "NN") (:stem . "adenocarcinoma") (:form . "adenocarcinoma")\n  (:end . 232) (:start . 218) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1027.5) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009591@unknown@formal@none@1@S@The results demonstrate that alterations in NF kappaB family proteins, specifically the failure of p65 translocation to the nucleus, occur earlier and more frequently than the decrease in zeta-chain.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 166)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "zeta-chain") (:form . "zeta-chain") (:end . 198)\n  (:start . 188) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1027.6.1) (:span 88 95)))\n (:nscopes ((:id . :x1027.6.1) (:span 88 131)))\n (:identifiers (:sid . :s1027.6) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009592@unknown@formal@none@1@S@These defects are paralleled by an impaired ability to produce Th1 cytokines (IL-2 and IFN-gamma).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "parallel") (:form . "paralleled") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1027.7) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009593@unknown@formal@none@1@S@These initial changes are followed by the eventual loss of TCR zeta chain and p56(lck) and a marked decrease in cytotoxic function.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "eventual") (:form . "eventual") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "zeta") (:form . "zeta") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1027.8) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009594@unknown@formal@none@1@S@An increased rate of lysosomal degradation is one of the mechanisms responsible for the loss of zeta-chain.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "zeta-chain") (:form . "zeta-chain") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1027.9) (:did . :|9164948|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009595@unknown@formal@none@1@S@An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "isotype-specific") (:form . "isotype-specific")\n  (:end . 19) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 57) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 106)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 133) (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1028.1) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009596@unknown@formal@none@1@S@Patients with one type of major histocompatibility complex class II combined immunodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately controls the transcription of the three major human class II genes, HLA-DR, -DQ, and -DP.@(((:tag . "NNS") (:stem . "patient") (:form . "Patients") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 50) (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 93) (:start . 77) (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 149) (:start . 135) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 156)\n  (:start . 151) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 177)\n  (:start . 165) (:id . 68))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 204) (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 73))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 217)\n  (:start . 212) (:id . 74))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 223)\n  (:start . 218) (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 229)\n  (:start . 224) (:id . 76))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 235)\n  (:start . 230) (:id . 77))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 238) (:start . 236)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 244)\n  (:start . 239) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 252)\n  (:start . 246) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 253) (:start . 252)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "-DQ") (:form . "-DQ") (:end . 257) (:start . 254)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 258) (:start . 257)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "-DP") (:form . "-DP") (:end . 266) (:start . 263)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1028.2) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009597@unknown@formal@none@1@S@However, the experimentally derived B-lymphoblastoid cell line, clone 13, expresses high levels of HLADQ in the absence of HLA-DR and HLA-DP, despite its mapping by complementation analysis to this group.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "b-lymphoblastoid") (:form . "B-lymphoblastoid")\n  (:end . 52) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "express") (:form . "expresses") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HLADQ") (:form . "HLADQ") (:end . 104)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HLA-DP") (:form . "HLA-DP") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 161)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "complementation") (:form . "complementation")\n  (:end . 180) (:start . 165) (:id . 71))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 189)\n  (:start . 181) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 192) (:start . 190)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 203)\n  (:start . 198) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1028.3.1) (:span 112 119)))\n (:nscopes ((:id . :x1028.3.1) (:span 112 140)))\n (:identifiers (:sid . :s1028.3) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009598@unknown@formal@none@1@S@It was possible that one of the clone 13 CIITA alleles bore a mutation that allowed HLA-DQ, but not HLA-DR or -DP transcription.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "VBD") (:stem . "bear") (:form . "bore") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 106)\n  (:start . 100) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "-DP") (:form . "-DP") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1028.4.2) (:span 7 15)))\n (:ncues ((:id . :x1028.4.1) (:span 96 99)))\n (:hscopes ((:id . :x1028.4.2) (:span 7 127)))\n (:nscopes ((:id . :x1028.4.1) (:span 96 127)))\n (:identifiers (:sid . :s1028.4) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009600@unknown@formal@none@1@S@We report here that ectopic expression of CIITA cDNAs derived by reverse transcriptase polymerase chain reaction from clone 13 do not restore expression of HLA-DQ in another CIITA-deficient cell line, RJ2.2.5.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "transcriptase") (:form . "transcriptase")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "JJ") (:stem . "ciita-deficient") (:form . "CIITA-deficient")\n  (:end . 189) (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 194) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 199) (:start . 195)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "RJ2.2.5") (:form . "RJ2.2.5") (:end . 208)\n  (:start . 201) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1028.6.1) (:span 130 133)))\n (:nscopes ((:id . :x1028.6.1) (:span 130 208)))\n (:identifiers (:sid . :s1028.6) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009601@unknown@formal@none@1@S@In addition, no CIITA protein is detectable in clone 13 nuclear extracts.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1028.7.1) (:span 13 15)))\n (:nscopes ((:id . :x1028.7.1) (:span 13 72)))\n (:identifiers (:sid . :s1028.7) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009602@unknown@formal@none@1@S@In contrast, somatic cell fusion between clone 13 and RJ2.2.5 restored expression of the HLA-DQ haplotype encoded by the RJ2.2.5 DQB gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "somatic") (:form . "somatic") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rj2.2.5") (:form . "RJ2.2.5") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "haplotype") (:form . "haplotype") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RJ2.2.5") (:form . "RJ2.2.5") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "NNP") (:stem . "DQB") (:form . "DQB") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1028.8) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009603@unknown@formal@none@1@S@Taken together, these data demonstrate the existence of an HLA-DQ isotype-specific trans-acting factor, which functions independently of CIITA.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HLA-DQ") (:form . "HLA-DQ") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "isotype-specific") (:form . "isotype-specific")\n  (:end . 82) (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "trans-acting") (:form . "trans-acting") (:end . 95)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 119)\n  (:start . 110) (:id . 58))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 133) (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 142)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1028.9) (:did . :|9166418|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009604@unknown@formal@none@1@S@Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "thrombin-stimulated")\n  (:form . "thrombin-stimulated") (:end . 80) (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1029.1) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009605@unknown@formal@none@1@S@BACKGROUND: Activated platelets tether and activate myeloid leukocytes.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "tether") (:form . "tether") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1029.2) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009606@unknown@formal@none@1@S@To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "myocardial") (:form . "myocardial") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "infarction") (:form . "infarction") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AMI") (:form . "AMI") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "leukocyte-platelet") (:form . "leukocyte-platelet")\n  (:end . 147) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "leukocyte-platelet") (:form . "leukocyte-platelet")\n  (:end . 197) (:start . 179) (:id . 69))\n ((:tag . "NNS") (:stem . "conjugate") (:form . "conjugates") (:end . 208)\n  (:start . 198) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 220)\n  (:start . 212) (:id . 72))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 225) (:start . 221)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "AMI") (:form . "AMI") (:end . 229) (:start . 226)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1029.3.1) (:span 19 28)))\n (:hscopes ((:id . :x1029.3.1) (:span 19 93)))\n (:identifiers (:sid . :s1029.3) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009607@unknown@formal@none@1@S@METHODS AND RESULTS: We obtained peripheral venous blood samples in 20 patients with AMI before and daily for 5 days after direct percutaneous transluminal coronary angioplasty (PTCA) and in 20 patients undergoing elective PTCA.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "obtain") (:form . "obtained") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "venous") (:form . "venous") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AMI") (:form . "AMI") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "RB") (:stem . "daily") (:form . "daily") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 129)\n  (:start . 123) (:id . 64))\n ((:tag . "JJ") (:stem . "percutaneous") (:form . "percutaneous") (:end . 142)\n  (:start . 130) (:id . 65))\n ((:tag . "JJ") (:stem . "transluminal") (:form . "transluminal") (:end . 155)\n  (:start . 143) (:id . 66))\n ((:tag . "JJ") (:stem . "coronary") (:form . "coronary") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "angioplasty") (:form . "angioplasty") (:end . 176)\n  (:start . 165) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PTCA") (:form . "PTCA") (:end . 182) (:start . 178)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 193) (:start . 191)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 202)\n  (:start . 194) (:id . 75))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 213)\n  (:start . 203) (:id . 76))\n ((:tag . "JJ") (:stem . "elective") (:form . "elective") (:end . 222)\n  (:start . 214) (:id . 77))\n ((:tag . "NNP") (:stem . "PTCA") (:form . "PTCA") (:end . 227) (:start . 223)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1029.4) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009608@unknown@formal@none@1@S@Throughout the study period, CD41 immunofluorescence of leukocytes (flow cytometry) revealed increased leukocyte-platelet adhesion in patients with AMI compared with control patients (mean ± SE of fluorescence [channels] before PTCA: 77 ± 16 versus 35 ± 9; P = .003).@(((:tag . "IN") (:stem . "throughout") (:form . "Throughout") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd41") (:form . "CD41") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 52) (:start . 34) (:id . 48))\n ((:tag . 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5009610@unknown@formal@none@1@S@Within 2 hours, this resulted in increased mRNA for interleukin (IL),1 beta, IL-8, and monocyte chemoattractant protein (MCP)-1 in unfractionated leukocytes.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "IL),1") (:form . "IL),1") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . "NN") (:stem . "chemoattractant") (:form . "chemoattractant")\n  (:end . 111) (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "MCP)-1") (:form . "MCP)-1") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unfractionated") (:form . "unfractionated")\n  (:end . 145) (:start . 131) (:id . 66))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1029.7) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009611@unknown@formal@none@1@S@After 4 hours, IL-1 beta and IL-8 concentration of the cell-free supernatant had increased by 268 ± 36% and 210 ± 7%, respectively, and cellular MCP-1 content had increased by 170 ± 8%.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 47) (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "supernatant") (:form . "supernatant") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "268") (:form . "268") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "CD") (:stem . "210") (:form . "210") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 113) (:start . 112)\n  (:id . 64))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 115) (:start . 114)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 116) (:start . 115)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 67))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 130)\n  (:start . 118) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 144)\n  (:start . 136) (:id . 71))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 150)\n  (:start . 145) (:id . 72))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 158)\n  (:start . 151) (:id . 73))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 162) (:start . 159)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 172)\n  (:start . 163) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 76))\n ((:tag . "CD") (:stem . "170") (:form . "170") (:end . 179) (:start . 176)\n  (:id . 77))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 181) (:start . 180)\n  (:id . 78))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 183) (:start . 182)\n  (:id . 79))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 184) (:start . 183)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1029.8) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009612@unknown@formal@none@1@S@Addition of activated platelets to adherent monocytes had a similar effect and was associated with nuclear factor-kappa B activation.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 119)\n  (:start . 107) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1029.9) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009613@unknown@formal@none@1@S@Inhibition of binding by anti-P selectin antibodies reduced the effect of activated platelets on cytokine production.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti-p") (:form . "anti-P") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "selectin") (:form . "selectin") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1029.10) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009614@unknown@formal@none@1@S@CONCLUSIONS: In patients with AMI, leukocyte-platelet adhesion is increased.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "AMI") (:form . "AMI") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "leukocyte-platelet") (:form . "leukocyte-platelet")\n  (:end . 53) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1029.11) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009615@unknown@formal@none@1@S@Binding of activated platelets induces IL-1 beta, IL-8, and MCP-1 in leukocytes.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1029.12) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009616@unknown@formal@none@1@S@Our findings suggest that leukocyte-platelet adhesion contributes to the regulation of inflammatory responses in AMI.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "leukocyte-platelet") (:form . "leukocyte-platelet")\n  (:end . 44) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 53)\n  (:start . 45) (:id . 47))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 65)\n  (:start . 54) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 99)\n  (:start . 87) (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 109)\n  (:start . 100) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AMI") (:form . "AMI") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1029.13.1) (:span 13 20)))\n (:hscopes ((:id . :x1029.13.1) (:span 13 116)))\n (:identifiers (:sid . :s1029.13) (:did . :|9170401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009617@unknown@formal@none@1@S@The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "tbp-associated") (:form . "TBP-associated")\n  (:end . 68) (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "tafii32") (:form . "TAFII32") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1030.1) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009618@unknown@formal@none@1@S@The class II trans- activator (CIITA) is the main transcriptional co-activator for the expression of MHC class II proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "trans-") (:form . "trans-") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 65) (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "co-activator") (:form . "co-activator") (:end . 78)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1030.2) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009620@unknown@formal@none@1@S@Analyses of the primary amino acid sequence of the activation domain predict the presence of three alpha-helices, each with a high proportion of acidic residues.@(((:tag . "NNS") (:stem . "analysis") (:form . "Analyses") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "alpha-helice") (:form . "alpha-helices")\n  (:end . 112) (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 141)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 160)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1030.4) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009621@unknown@formal@none@1@S@Using site-directed mutagenesis, we found that two of these predicted alpha-helices are required for full transcriptional activation by CIITA.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "site-directed") (:form . "site-directed")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "alpha-helice") (:form . "alpha-helices")\n  (:end . 83) (:start . 70) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 121) (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 132)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1030.5) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009622@unknown@formal@none@1@S@Moreover, a CIITA protein in which both functional alpha-helices have been deleted displays a dominant negative phenotype.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "alpha-helice") (:form . "alpha-helices")\n  (:end . 64) (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1030.6) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009623@unknown@formal@none@1@S@This activation domain of CIITA interacts with the 32 kDa subunit of the general transcription complex TFIID, TAFII32.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NNP") (:stem . "TFIID") (:form . "TFIID") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TAFII32") (:form . "TAFII32") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1030.7) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009624@unknown@formal@none@1@S@Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32.@(((:tag . "VBN") (:stem . "decrease") (:form . "Decreased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 25) (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 60)\n  (:start . 51) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 103)\n  (:start . 98) (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 111)\n  (:start . 104) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TAFII32") (:form . "TAFII32") (:end . 130)\n  (:start . 123) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1030.8) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009625@unknown@formal@none@1@S@We conclude that interactions between TAFII32 and CIITA are responsible for activation of class II genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "TAFII32") (:form . "TAFII32") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1030.9) (:did . :|9171108|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009626@unknown@formal@none@1@S@Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.@(((:tag . "NN") (:stem . "tap") (:form . "Tap") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 12) (:start . 7)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 21)\n  (:start . 13) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tip") (:form . "tip") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "saimiri") (:form . "saimiri") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1031.1) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009627@unknown@formal@none@1@S@Tip of herpesvirus saimiri associates with Lck and down-regulates Lck-mediated activation.@(((:tag . "NNP") (:stem . "Tip") (:form . "Tip") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "saimiri") (:form . "saimiri") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Lck") (:form . "Lck") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "down-regulate") (:form . "down-regulates")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "lck-mediated") (:form . "Lck-mediated") (:end . 78)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1031.2) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009628@unknown@formal@none@1@S@We identified a novel cellular Tip-associated protein (Tap) by a yeast two-hybrid screen.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "tip-associated") (:form . "Tip-associated")\n  (:end . 45) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tap") (:form . "Tap") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1031.3) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009630@unknown@formal@none@1@S@Expression of Tip and Tap in Jurkat-T cells induced dramatic cell aggregation.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Tip") (:form . "Tip") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tap") (:form . "Tap") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Jurkat-T") (:form . "Jurkat-T") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "aggregation") (:form . "aggregation") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1031.5) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009631@unknown@formal@none@1@S@Aggregation was likely caused by the up-regulated surface expression of adhesion molecules including integrin alpha, L-selectin, ICAM-3, and H-CAM.@(((:tag . "NNP") (:stem . "Aggregation") (:form . "Aggregation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "integrin") (:form . "integrin") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 115)\n  (:start . 110) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "L-selectin") (:form . "L-selectin") (:end . 127)\n  (:start . 117) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ICAM-3") (:form . "ICAM-3") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "H-CAM") (:form . "H-CAM") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1031.6.1) (:span 16 22)))\n (:hscopes ((:id . :x1031.6.1) (:span 0 146)))\n (:identifiers (:sid . :s1031.6) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009632@unknown@formal@none@1@S@Furthermore, NF-kappaB transcriptional factor of aggregated cells had approximately 40-fold higher activity than that of parental cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 38) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "aggregated") (:form . "aggregated") (:end . 59)\n  (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "RB") (:stem . "40-fold") (:form . "40-fold") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 98) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 129)\n  (:start . 121) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1031.7) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009633@unknown@formal@none@1@S@Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tap") (:form . "Tap") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 19)\n  (:start . 13) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 38)\n  (:start . 29) (:id . 50))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Tip") (:form . "Tip") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 97) (:start . 83) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 112)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "saimiri") (:form . "saimiri") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1031.8.1) (:span 13 19)))\n (:hscopes ((:id . :x1031.8.1) (:span 6 120)))\n (:identifiers (:sid . :s1031.8) (:did . :|9175835|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009634@unknown@formal@none@1@S@Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "bare") (:form . "bare") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "syndrome-associated")\n  (:form . "syndrome-associated") (:end . 73) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 104) (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1032.1) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009635@unknown@formal@none@1@S@CIITA is a positive regulator of class II major histocompatibility complex gene transcription that has been found to be defective in one of the five complementation groups of class II major histocompatibility complex-negative cell lines.@(((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 66) (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "complementation") (:form . "complementation")\n  (:end . 164) (:start . 149) (:id . 67))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 171)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 208) (:start . 190) (:id . 73))\n ((:tag . "JJ") (:stem . "complex-negative") (:form . "complex-negative")\n  (:end . 225) (:start . 209) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 230) (:start . 226)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 236)\n  (:start . 231) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1032.2) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009636@unknown@formal@none@1@S@Its N-terminal region is capable of activating transcription from a reporter gene when fused to a DNA binding domain.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1032.3) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009637@unknown@formal@none@1@S@We have investigated the mechanism of transactivation mediated by the CIITA activation domain by studying its role in the process of transcription initiation and elongation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "study") (:form . "studying") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 146) (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 172)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1032.4) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009638@unknown@formal@none@1@S@Specifically the altered specificity TBP (TATA box binding protein) assay has been used to analyze the response of the CIITA activation domain to mutations in TBP known to disrupt its interaction with its associated general factors.@(((:tag . "RB") (:stem . "specifically") (:form . "Specifically") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 155)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 179)\n  (:start . 172) (:id . 72))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 195)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 200) (:start . 196)\n  (:id . 75))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 215)\n  (:start . 205) (:id . 77))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 223)\n  (:start . 216) (:id . 78))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 231)\n  (:start . 224) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1032.5) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009640@unknown@formal@none@1@S@A TBP mutant defective in interaction with TBP-associated factor TAFII250 also failed to mediate transactivation through the CIITA activation domain.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tbp-associated") (:form . "TBP-associated")\n  (:end . 57) (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "tafii250") (:form . "TAFII250") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 85) (:start . 79)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 112) (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 130)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1032.7.1) (:span 79 85)))\n (:nscopes ((:id . :x1032.7.1) (:span 79 148)))\n (:identifiers (:sid . :s1032.7) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009641@unknown@formal@none@1@S@Certain interactions between TBP and general factors that are specifically required for acidic activation domains were also required for CIITA-mediated transactivation to reach its full potential.@(((:tag . "JJ") (:stem . "certain") (:form . "Certain") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ciita-mediated") (:form . "CIITA-mediated")\n  (:end . 151) (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 167) (:start . 152) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 63))\n ((:tag . "VB") (:stem . "reach") (:form . "reach") (:end . 176)\n  (:start . 171) (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 180) (:start . 177)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 185) (:start . 181)\n  (:id . 66))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 195)\n  (:start . 186) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1032.8) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009642@unknown@formal@none@1@S@Finally, like VP16, CIITA was able to stimulate elongation of transcription.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "VP16") (:form . "VP16") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1032.9) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009643@unknown@formal@none@1@S@Overall the mechanism of transactivation by the human B-cell-specific CIITA is very similar to that mediated by the herpes virus transactivator VP16 in the ways that have been tested.@(((:tag . "RB") (:stem . "overall") (:form . "Overall") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 69) (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 75) (:start . 70)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "herpes") (:form . "herpes") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 143) (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "vp16") (:form . "VP16") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "way") (:form . "ways") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1032.10) (:did . :|9177216|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009644@unknown@formal@none@1@S@Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5.@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "bare") (:form . "bare") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "syndrome-associated")\n  (:form . "syndrome-associated") (:end . 82) (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "transactivator") (:form . "transactivators")\n  (:end . 98) (:start . 83) (:id . 52))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 104)\n  (:start . 99) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RFX5") (:form . "RFX5") (:end . 113) (:start . 109)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1033.1) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009645@unknown@formal@none@1@S@Two of the genes defective in the five complementation groups identified in the class II-negative bare lymphocyte syndrome or corresponding laboratory mutants have been cloned.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complementation") (:form . "complementation")\n  (:end . 54) (:start . 39) (:id . 50))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ii-negative") (:form . "II-negative") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "bare") (:form . "bare") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 175)\n  (:start . 169) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1033.2) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009646@unknown@formal@none@1@S@One gene encodes a protein, RFX5, that is a member of the RFX family of DNA binding proteins.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RFX5") (:form . "RFX5") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 50)\n  (:start . 44) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RFX") (:form . "RFX") (:end . 61) (:start . 58)\n  (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 68)\n  (:start . 62) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 75) (:start . 72)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 83)\n  (:start . 76) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 92)\n  (:start . 84) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1033.3) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009647@unknown@formal@none@1@S@The other, CIITA, encodes a large protein with a defined acidic transcriptional activation domain; this protein does not interact with DNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 41)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 56)\n  (:start . 49) (:id . 53))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 79) (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1033.4.1) (:span 117 120)))\n (:nscopes ((:id . :x1033.4.1) (:span 117 138)))\n (:identifiers (:sid . :s1033.4) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009648@unknown@formal@none@1@S@Expression plasmids encoding regions of RFX5 fused to the GAL4 DNA binding domain activated transcription from a reporter construct containing GAL4 sites in a cotransfection assay in the Raji human B cell line.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rfx5") (:form . "RFX5") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 142)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "gal4") (:form . "GAL4") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 173) (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 179)\n  (:start . 174) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 199) (:start . 198)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 204) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 209) (:start . 205)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1033.5) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009650@unknown@formal@none@1@S@Furthermore, these plasmids were not active in RJ2.2.5, an in vitro mutagenized derivative of Raji in which both copies of CIITA are defective.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RJ2.2.5") (:form . "RJ2.2.5") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mutagenize") (:form . "mutagenized") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1033.7.1) (:span 33 36)))\n (:nscopes ((:id . :x1033.7.1) (:span 33 142)))\n (:identifiers (:sid . :s1033.7) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009651@unknown@formal@none@1@S@Transcriptional activation by the RFX5 fusion protein could be restored in RJ2.2.5 by cotransfection with a CIITA expression plasmid.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RFX5") (:form . "RFX5") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "restore") (:form . "restored") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rj2.2.5") (:form . "RJ2.2.5") (:end . 82)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 100) (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1033.8) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009652@unknown@formal@none@1@S@Finally, a direct interaction between RFX5 and CIITA was detected with the yeast two-hybrid and far-Western blot assays.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "RFX5") (:form . "RFX5") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "far-western") (:form . "far-Western") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1033.9) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009653@unknown@formal@none@1@S@Thus, RFX5 can activate transcription only in cooperation with CIITA.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "rfx5") (:form . "RFX5") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cooperation") (:form . "cooperation") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1033.10) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009654@unknown@formal@none@1@S@RFX5 and CIITA associate to form a complex capable of activating transcription from class II major histocompatibility complex promoters.@(((:tag . "NNP") (:stem . "RFX5") (:form . "RFX5") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "associate") (:form . "associate") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 117) (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1033.11) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009655@unknown@formal@none@1@S@In this complex, promoter specificity is determined by the DNA binding domain of RFX5 and the general transcription apparatus is recruited by the acidic activation domain of CIITA.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RFX5") (:form . "RFX5") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "apparatus") (:form . "apparatus") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1033.12) (:did . :|9177217|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009656@unknown@formal@none@1@S@Reactive oxygen species and antioxidants in inflammatory diseases.@(((:tag . "JJ") (:stem . "reactive") (:form . "Reactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 56)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1034.1) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009657@unknown@formal@none@1@S@This paper aims to review the role of free radical-induced tissue damage and antioxidant defence mechanisms in inflammatory diseases that involve pathogenic processes similar to the periodontal diseases.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "aim") (:form . "aims") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "review") (:form . "review") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "radical-induced") (:form . "radical-induced")\n  (:end . 58) (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "defence") (:form . "defence") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 123)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 145)\n  (:start . 138) (:id . 62))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 156)\n  (:start . 146) (:id . 63))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 166)\n  (:start . 157) (:id . 64))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 174)\n  (:start . 167) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "periodontal") (:form . "periodontal") (:end . 193)\n  (:start . 182) (:id . 68))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 202)\n  (:start . 194) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1034.2) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009658@unknown@formal@none@1@S@There is a clearly defined and substantial role for free radicals or reactive oxygen species (ROS) in periodontitis, but little research has been performed in this area.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "radical") (:form . "radicals") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ROS") (:form . "ROS") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "periodontitis") (:form . "periodontitis")\n  (:end . 115) (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 155)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 163) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1034.3) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009660@unknown@formal@none@1@S@The recent discovery of the transcription factor nuclear factor kappa B (NF-kappa B) is reviewed and several potential pathways for cytokine-induced periodontal tissue damage, mediated by NF-kappa B1 are discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 148) (:start . 132) (:id . 64))\n ((:tag . "JJ") (:stem . "periodontal") (:form . "periodontal") (:end . 160)\n  (:start . 149) (:id . 65))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 174)\n  (:start . 168) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 196)\n  (:start . 188) (:id . 71))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 213)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1034.5.1) (:span 109 118)))\n (:hscopes ((:id . :x1034.5.1) (:span 109 199)))\n (:identifiers (:sid . :s1034.5) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009661@unknown@formal@none@1@S@Emphasis is placed on cytokines that have been studied in periodontitis, principally TNF-alpha, IL-1, IL-6, IL-8 and beta-interferon.@(((:tag . "NN") (:stem . "emphasis") (:form . "Emphasis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "place") (:form . "placed") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "periodontitis") (:form . "periodontitis")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "principally") (:form . "principally") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "beta-interferon") (:form . "beta-interferon")\n  (:end . 132) (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1034.6) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009662@unknown@formal@none@1@S@The link between cellular production of such important mediators of inflammation and the antioxidant (AO) thiols, cysteine and reduced glutathione (GSH), is discussed and it is hypothesised that NF-kappa B antagonists may offer important therapeutic benefits.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 80)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 100)\n  (:start . 89) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AO") (:form . "AO") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "thiol") (:form . "thiols") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 146)\n  (:start . 135) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 166)\n  (:start . 157) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 176) (:start . 174)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "hypothesise") (:form . "hypothesised") (:end . 189)\n  (:start . 177) (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 203)\n  (:start . 195) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 205) (:start . 204)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 217)\n  (:start . 206) (:id . 78))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 221) (:start . 218)\n  (:id . 79))\n ((:tag . "VB") (:stem . "offer") (:form . "offer") (:end . 227)\n  (:start . 222) (:id . 80))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 237)\n  (:start . 228) (:id . 81))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 249)\n  (:start . 238) (:id . 82))\n ((:tag . "NNS") (:stem . "benefit") (:form . "benefits") (:end . 258)\n  (:start . 250) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1034.7.1) (:span 218 221))\n  ((:id . :x1034.7.2) (:span 177 189)))\n (:hscopes ((:id . :x1034.7.1) (:span 218 258))\n  ((:id . :x1034.7.2) (:span 177 258)))\n (:identifiers (:sid . :s1034.7) (:did . :|9178107|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009663@unknown@formal@none@1@S@Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 46))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 62)\n  (:start . 50) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1035.1) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009664@unknown@formal@none@1@S@Elf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family.@(((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lymphoid-specific") (:form . "lymphoid-specific")\n  (:end . 28) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1035.2) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009665@unknown@formal@none@1@S@It can bind to DNA target sequences within a variety of cytokine genes.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1035.3) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009666@unknown@formal@none@1@S@We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 43) (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "CD") (:stem . "86-265") (:form . "86-265") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1035.4) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009667@unknown@formal@none@1@S@Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gal4-elf-1") (:form . "Gal4-Elf-1") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "CD") (:stem . "86") (:form . "86") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "elf-1") (:form . "Elf-1") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 117) (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 198)\n  (:start . 188) (:id . 71))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 205)\n  (:start . 199) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1035.5) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009668@unknown@formal@none@1@S@Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Elf-1") (:form . "Elf-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "e74") (:form . "E74") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 55))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 109)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "e74") (:form . "E74") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 137)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1035.6) (:did . :|9180266|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009670@unknown@formal@none@1@S@Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HSF2-beta") (:form . "HSF2-beta") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "JJ") (:stem . "hemin-induced") (:form . "hemin-induced")\n  (:end . 50) (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 55) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 61) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 107) (:start . 92) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 54))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 115) (:start . 111)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1036.1) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009671@unknown@formal@none@1@S@Acquisition of heat shock factor 2 (HSF2) DNA binding activity is accompanied by induced transcription of heat shock genes in hemin-treated K562 cells undergoing erythroid differentiation.@(((:tag . "NNP") (:stem . "Acquisition") (:form . "Acquisition") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hsf2") (:form . "HSF2") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "hemin-treated") (:form . "hemin-treated")\n  (:end . 139) (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 161)\n  (:start . 151) (:id . 67))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 187) (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1036.2) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009672@unknown@formal@none@1@S@Previous studies revealed that HSF2 consists of two alternatively spliced isoforms, HSF2-alpha and HSF2-beta, whose relative abundance is developmentally regulated and varies between different tissues.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hsf2") (:form . "HSF2") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "alternatively") (:form . "alternatively")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "VBN") (:stem . "splice") (:form . "spliced") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HSF2-alpha") (:form . "HSF2-alpha") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HSF2-beta") (:form . "HSF2-beta") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 153) (:start . 138) (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 163)\n  (:start . 154) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "vary") (:form . "varies") (:end . 174)\n  (:start . 168) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 182)\n  (:start . 175) (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 192)\n  (:start . 183) (:id . 67))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 200)\n  (:start . 193) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1036.3) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009673@unknown@formal@none@1@S@To investigate whether the molar ratio of HSF2-alpha and HSF2-beta isoforms is crucial for the activation of HSF2 and whether the HSF2 isoforms play functionally distinct roles during the hemin-mediated erythroid differentiation, we generated cell clones expressing different levels of HSF2-alpha and HSF2-beta.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molar") (:form . "molar") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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"clones") (:end . 254)\n  (:start . 248) (:id . 78))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 265)\n  (:start . 255) (:id . 79))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 275)\n  (:start . 266) (:id . 80))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 282)\n  (:start . 276) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 285) (:start . 283)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HSF2-alpha") (:form . "HSF2-alpha") (:end . 296)\n  (:start . 286) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 300) (:start . 297)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "HSF2-beta") (:form . "HSF2-beta") (:end . 310)\n  (:start . 301) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 311) (:start . 310)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x1036.4.1) (:span 118 125))\n  ((:id . :x1036.4.2) (:span 15 22)))\n (:hscopes ((:id . :x1036.4.1) (:span 118 228))\n  ((:id . :x1036.4.2) (:span 15 113)))\n (:identifiers (:sid . :s1036.4) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009674@unknown@formal@none@1@S@We show that in parental K562 cells, the HSF2-alpha isoform is predominantly expressed and HSF2 can be activated upon hemin treatment.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HSF2-alpha") (:form . "HSF2-alpha") (:end . 51)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 76) (:start . 63) (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hsf2") (:form . "HSF2") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1036.5) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009675@unknown@formal@none@1@S@In contrast, when HSF2-beta is expressed at levels exceeding those of endogenous HSF2-alpha, the hemin-induced DNA binding activity and transcription of heat shock genes are repressed, whereas overexpression of HSF2-alpha results in an enhanced hemin response.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HSF2-beta") (:form . "HSF2-beta") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "VBG") (:stem . "exceed") (:form . "exceeding") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "NNP") (:stem . "HSF2-alpha") (:form . "HSF2-alpha") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hemin-induced") (:form . "hemin-induced")\n  (:end . 110) (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "repress") (:form . "repressed") (:end . 183)\n  (:start . 174) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 207) (:start . 193) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "HSF2-alpha") (:form . "HSF2-alpha") (:end . 221)\n  (:start . 211) (:id . 74))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 229)\n  (:start . 222) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 76))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 235) (:start . 233)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 244)\n  (:start . 236) (:id . 78))\n ((:tag . "NN") (:stem . "hemin") (:form . "hemin") (:end . 250)\n  (:start . 245) (:id . 79))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 259)\n  (:start . 251) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1036.6) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009676@unknown@formal@none@1@S@Furthermore, the hemin-induced accumulation of globin, known as a marker of erythroid differentiation, is decreased in cells overexpressing HSF2-beta.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hemin-induced") (:form . "hemin-induced")\n  (:end . 30) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 101) (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 139) (:start . 125) (:id . 62))\n ((:tag . "NNP") (:stem . "HSF2-beta") (:form . "HSF2-beta") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1036.7) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009677@unknown@formal@none@1@S@We suggest that HSF2-beta acts as a negative regulator of HSF2 activity during hemin-mediated erythroid differentiation of K562 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HSF2-beta") (:form . "HSF2-beta") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hsf2") (:form . "HSF2") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "hemin-mediated") (:form . "hemin-mediated")\n  (:end . 93) (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 119) (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "k562") (:form . "K562") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1036.8.1) (:span 3 10)))\n (:hscopes ((:id . :x1036.8.1) (:span 3 133)))\n (:identifiers (:sid . :s1036.8) (:did . :|9182556|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009678@unknown@formal@none@1@S@Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras.@(((:tag . "JJ") (:stem . "glucocorticoid-mediated")\n  (:form . "Glucocorticoid-mediated") (:end . 23) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 34)\n  (:start . 24) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 46)\n  (:start . 38) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 49))\n ((:tag . "NN") (:stem . "arteritis-scid") (:form . "arteritis-SCID")\n  (:end . 89) (:start . 75) (:id . 50))\n ((:tag . "NNS") (:stem . "chimera") (:form . "chimeras") (:end . 98)\n  (:start . 90) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1037.1) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009680@unknown@formal@none@1@S@Glucocorticoid therapy resolves clinical symptoms within hours to days, but therapy has to be continued over several years to prevent disease relapses.@(((:tag . "NN") (:stem . "glucocorticoid") (:form . "Glucocorticoid")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 22)\n  (:start . 15) (:id . 43))\n ((:tag . "VBZ") (:stem . "resolve") (:form . "resolves") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 56)\n  (:start . 50) (:id . 47))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 62) (:start . 57)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "continue") (:form . "continued") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "relapse") (:form . "relapses") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1037.3) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009681@unknown@formal@none@1@S@It is not known whether and how glucocorticoids affect the function of the inflammatory infiltrate or why the disease persists subclinically despite chronic treatment.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 47) (:start . 32) (:id . 49))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 87)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "infiltrate") (:form . "infiltrate") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "VBZ") (:stem . "persist") (:form . "persists") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "RB") (:stem . "subclinically") (:form . "subclinically")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 166)\n  (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1037.4.1) (:span 16 23)) ((:id . :x1037.4.2) (:span 6 15)))\n (:hscopes ((:id . :x1037.4.1) (:span 16 98))\n  ((:id . :x1037.4.2) (:span 6 166)))\n (:identifiers (:sid . :s1037.4) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009682@unknown@formal@none@1@S@GCA is self-sustained in temporal arteries engrafted into SCID mice, providing a model in which the mechanisms of action and limitations of glucocorticoid therapy can be examined in vivo.@(((:tag . "NNP") (:stem . "GCA") (:form . "GCA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "self-sustained") (:form . "self-sustained")\n  (:end . 21) (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "artery") (:form . "arteries") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "engraft") (:form . "engrafted") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SCID") (:form . "SCID") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "limitation") (:form . "limitations") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 154) (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1037.5) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009683@unknown@formal@none@1@S@Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase.@(((:tag . "NNP") (:stem . "Administration") (:form . "Administration")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "temporal") (:form . "temporal") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "artery-scid") (:form . "artery-SCID") (:end . 55)\n  (:start . 44) (:id . 47))\n ((:tag . "NNS") (:stem . "chimera") (:form . "chimeras") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "wk") (:form . "wk") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 128)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 165)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 172)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 187) (:start . 173) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 195) (:start . 191)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 205)\n  (:start . 197) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 206) (:start . 205)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 215) (:start . 211)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 220) (:start . 216)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 228) (:start . 226)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "diminish") (:form . "diminished") (:end . 243)\n  (:start . 233) (:id . 81))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 254)\n  (:start . 244) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 257) (:start . 255)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 267)\n  (:start . 258) (:id . 84))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 270) (:start . 268)\n  (:id . 85))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 279)\n  (:start . 271) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1037.6) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009684@unknown@formal@none@1@S@In contrast, synthesis of IFN-gamma mRNA was only slightly decreased, and expression of TGF-beta1 was unaffected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TGF-beta1") (:form . "TGF-beta1") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1037.7) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009685@unknown@formal@none@1@S@These findings correlated with activation of the IkappaBalpha gene and blockade of the nuclear translocation of NFkappaB in the xenotransplanted tissue.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 108) (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "xenotransplante") (:form . "xenotransplanted")\n  (:end . 144) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 151)\n  (:start . 145) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1037.8) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009686@unknown@formal@none@1@S@Dose-response experiments suggested that steroid doses currently used in clinical medicine are suboptimal in repressing NFkappaB-mediated cytokine production in the inflammatory lesions.@(((:tag . "JJ") (:stem . "dose-response") (:form . "Dose-response")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 35)\n  (:start . 26) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 48)\n  (:start . 41) (:id . 46))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 64)\n  (:start . 55) (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 69) (:start . 65)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "medicine") (:form . "medicine") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "suboptimal") (:form . "suboptimal") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "repress") (:form . "repressing") (:end . 119)\n  (:start . 109) (:id . 56))\n ((:tag . "JJ") (:stem . "nfkappab-mediated") (:form . "NFkappaB-mediated")\n  (:end . 137) (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 146)\n  (:start . 138) (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 157)\n  (:start . 147) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 177)\n  (:start . 165) (:id . 62))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 185)\n  (:start . 178) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1037.9.1) (:span 26 35)))\n (:hscopes ((:id . :x1037.9.1) (:span 26 185)))\n (:identifiers (:sid . :s1037.9) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009687@unknown@formal@none@1@S@Chronic steroid therapy was able to deplete the T cell products IL-2 and IFN-gamma, whereas the activation of tissue-infiltrating macrophages was only partially affected.@(((:tag . "JJ") (:stem . "chronic") (:form . "Chronic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "deplete") (:form . "deplete") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tissue-infiltrating")\n  (:form . "tissue-infiltrating") (:end . 129) (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 141)\n  (:start . 130) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 169)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1037.10) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009688@unknown@formal@none@1@S@IL-1beta transcription was abrogated; in contrast, TGF-beta1 mRNA synthesis was steroid resistant.@(((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TGF-beta1") (:form . "TGF-beta1") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1037.11) (:did . :|9185506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009690@unknown@formal@none@1@S@Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.@(((:tag . "NNP") (:stem . "Histamine") (:form . "Histamine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h2") (:form . "H2") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 119)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1038.1) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009691@unknown@formal@none@1@S@We examined the effects of histamine and its agonists on the expression of the c-fos and c-myc proto-oncogenes at the transcriptional and translational levels in the human promonocytic U937 cell line.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "histamine") (:form . "histamine") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 110) (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 133) (:start . 118) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "translational") (:form . "translational")\n  (:end . 151) (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 158)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 171)\n  (:start . 166) (:id . 68))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 184)\n  (:start . 172) (:id . 69))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 189) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 194) (:start . 190)\n  (:id . 71))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 199) (:start . 195)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1038.2) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009692@unknown@formal@none@1@S@Histamine transiently increased cAMP and c-fos expression through H2 receptors.@(((:tag . "NNP") (:stem . "Histamine") (:form . "Histamine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 31)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "h2") (:form . "H2") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1038.3) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009693@unknown@formal@none@1@S@Dibutyryl cAMP also increased c-fos mRNA and protein, and levels remained elevated even after 12 hr of treatment.@(((:tag . "NNP") (:stem . "Dibutyryl") (:form . "Dibutyryl") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1038.4) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009694@unknown@formal@none@1@S@Dose-dependence studies using histamine and dimaprit showed that the EC50 values for cAMP production and c-fos increase were similar, suggesting that cAMP might be involved in c-fos induction via H2 receptors.@(((:tag . "NN") (:stem . "dose-dependence") (:form . "Dose-dependence")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 29) (:start . 24)\n  (:id . 44))\n ((:tag . "NN") (:stem . "histamine") (:form . "histamine") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dimaprit") (:form . "dimaprit") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 59) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ec50") (:form . "EC50") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 172)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 181)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "h2") (:form . "H2") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 208)\n  (:start . 199) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1038.5.1) (:span 155 160))\n  ((:id . :x1038.5.2) (:span 134 144)))\n (:hscopes ((:id . :x1038.5.1) (:span 150 208))\n  ((:id . :x1038.5.2) (:span 134 208)))\n (:identifiers (:sid . :s1038.5) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009695@unknown@formal@none@1@S@Furthermore, studies carried out using H7, a protein kinase A/protein kinase C inhibitor, blocked c-fos induction, whereas no effect was observed with bisindolylmaleimide, a specific protein kinase C inhibitor.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "carry") (:form . "carried") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "h7") (:form . "H7") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NNP") (:stem . "A/protein") (:form . "A/protein") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "bisindolylmaleimide")\n  (:form . "bisindolylmaleimide") (:end . 170) (:start . 151) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 182)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 190)\n  (:start . 183) (:id . 72))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 197)\n  (:start . 191) (:id . 73))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1038.6.1) (:span 123 125)))\n (:nscopes ((:id . :x1038.6.1) (:span 123 209)))\n (:identifiers (:sid . :s1038.6) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009696@unknown@formal@none@1@S@No modification of c-myc expression could be detected on treatment with histamine or its analogues.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "histamine") (:form . "histamine") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "analogue") (:form . "analogues") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1038.7.1) (:span 0 2)))\n (:nscopes ((:id . :x1038.7.1) (:span 0 98)))\n (:identifiers (:sid . :s1038.7) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009697@unknown@formal@none@1@S@Nevertheless, dibutyryl cAMP induced a down-regulation of the levels of this proto-oncogene.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 54) (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 91) (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1038.8) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009698@unknown@formal@none@1@S@In addition, dibutyryl cAMP inhibited cell growth in a dose-dependent manner, whereas histamine failed to affect proliferation and differentiation of U937 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dibutyryl") (:form . "dibutyryl") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 69) (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "histamine") (:form . "histamine") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 146) (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1038.9.1) (:span 96 102)))\n (:nscopes ((:id . :x1038.9.1) (:span 96 160)))\n (:identifiers (:sid . :s1038.9) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009700@unknown@formal@none@1@S@This homologous mechanism of H2 receptor desensitization was time dependent.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "h2") (:form . "H2") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "desensitization") (:form . "desensitization")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1038.11) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009701@unknown@formal@none@1@S@These results indicate that histamine activates several mechanisms involved in the induction of differentiation, such as cAMP and c-fos production, but fails to promote differentiation of U937 cells, apparently due to the rapid desensitization of H2 receptors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "histamine") (:form . "histamine") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 111) (:start . 96) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 168)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 184) (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 69))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 198)\n  (:start . 193) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 72))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 210)\n  (:start . 200) (:id . 73))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 214) (:start . 211)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 227)\n  (:start . 222) (:id . 77))\n ((:tag . "NN") (:stem . "desensitization") (:form . "desensitization")\n  (:end . 243) (:start . 228) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 79))\n ((:tag . "NN") (:stem . "h2") (:form . "H2") (:end . 249) (:start . 247)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 259)\n  (:start . 250) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1038.12.1) (:span 200 210))\n  ((:id . :x1038.12.3) (:span 14 27)))\n (:ncues ((:id . :x1038.12.2) (:span 152 157)))\n (:hscopes ((:id . :x1038.12.1) (:span 200 259))\n  ((:id . :x1038.12.3) (:span 14 259)))\n (:nscopes ((:id . :x1038.12.2) (:span 152 259)))\n (:identifiers (:sid . :s1038.12) (:did . :|9187264|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009702@unknown@formal@none@1@S@Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cytomegalovirus") (:form . "cytomegalovirus")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 43) (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 54)\n  (:start . 44) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "RB") (:stem . "concurrently") (:form . "concurrently") (:end . 121)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1-") (:form . "AP-1-") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 152) (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 158)\n  (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 179) (:start . 166) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1039.1) (:did . :|9188651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009703@unknown@formal@none@1@S@Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion.@(((:tag . "NNP") (:stem . "Cytomegalovirus") (:form . "Cytomegalovirus")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 150)\n  (:start . 141) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1039.2) (:did . :|9188651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009704@unknown@formal@none@1@S@The functional analysis of the IL-8 gene revealed that both AP-1- and NF-kappaB factor-binding elements were involved in conferring the responsiveness to CMV.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "AP-1-") (:form . "AP-1-") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "factor-binding") (:form . "factor-binding")\n  (:end . 94) (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "confer") (:form . "conferring") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 150) (:start . 136) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1039.3) (:did . :|9188651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009705@unknown@formal@none@1@S@Moreover, electrophoretic mobility shift assays demonstrated that CMV induced the formation of NF-kappaB and AP-1 complexes.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 60)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1039.4) (:did . :|9188651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009706@unknown@formal@none@1@S@These results suggest that CMV activates these transcriptional factors, resulting in IL-8 gene expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CMV") (:form . "CMV") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1039.5.1) (:span 14 21)))\n (:hscopes ((:id . :x1039.5.1) (:span 14 105)))\n (:identifiers (:sid . :s1039.5) (:did . :|9188651|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009707@unknown@formal@none@1@S@Concomitant downregulation of IgH 3' enhancer activity and c-myc expression in a plasmacytoma x fibroblast environment: implications for dysregulation of translocated c-myc.@(((:tag . "JJ") (:stem . "concomitant") (:form . "Concomitant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "downregulation") (:form . "downregulation")\n  (:end . 26) (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 93)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 132)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 150) (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "translocate") (:form . "translocated") (:end . 166)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1040.1) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009708@unknown@formal@none@1@S@Regulation of immunoglobulin heavy chain (IgH) gene expression is controlled by a B cell-specific promoter, intronic enhancer and additional B cell-specific enhancer elements identified recently in the 3' end of the IgH locus.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 97) (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intronic") (:form . "intronic") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 156) (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 185)\n  (:start . 175) (:id . 68))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 194)\n  (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 203) (:start . 202)\n  (:id . 72))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 204) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 225)\n  (:start . 220) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1040.2) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009710@unknown@formal@none@1@S@We have used a somatic cell hybridization approach to genetically analyse regulation of the activity of the IgH 3' enhancer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "somatic") (:form . "somatic") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 41) (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "VB") (:stem . "analyse") (:form . "analyse") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1040.4) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009711@unknown@formal@none@1@S@When mouse MPC11 plasmacytoma cells, in which the IgH 3' enhancer is active, are fused with fibroblasts, Ig expression is extinguished at the level of transcription.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mpc11") (:form . "MPC11") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 75)\n  (:start . 69) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 86) (:start . 81)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 103)\n  (:start . 92) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "extinguish") (:form . "extinguished") (:end . 134)\n  (:start . 122) (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 164) (:start . 151) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1040.5) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009712@unknown@formal@none@1@S@Here we show that in a MPC11 plasmacytoma x fibroblast environment, the IgH 3' enhancer is transcriptionally inactive.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mpc11") (:form . "MPC11") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 41)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 66)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 108) (:start . 91) (:id . 60))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1040.6) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009713@unknown@formal@none@1@S@Furthermore, we demonstrate that binding of several B cell-specific transcription factors, essential for IgH 3' enhancer activity, is lacking, which may explain 3' enhancer inactivity, although the binding of repressors cannot be excluded.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 162) (:start . 161)\n  (:id . 69))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 172)\n  (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "inactivity") (:form . "inactivity") (:end . 183)\n  (:start . 173) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 193)\n  (:start . 185) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 205)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "repressor") (:form . "repressors") (:end . 219)\n  (:start . 209) (:id . 78))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 226)\n  (:start . 220) (:id . 79))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 229) (:start . 227)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "exclude") (:form . "excluded") (:end . 238)\n  (:start . 230) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1040.7.1) (:span 220 238))\n  ((:id . :x1040.7.2) (:span 149 152)))\n (:ncues ((:id . :x1040.7.3) (:span 134 141)))\n (:hscopes ((:id . :x1040.7.1) (:span 194 238))\n  ((:id . :x1040.7.2) (:span 149 183)))\n (:nscopes ((:id . :x1040.7.3) (:span 33 141)))\n (:identifiers (:sid . :s1040.7) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009714@unknown@formal@none@1@S@Moreover, the high expression level of c-myc, characteristic of the parental MPC11 cells carrying the t(12;15) translocation, is down-regulated in the hybrids to that in unfused fibroblasts.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 60) (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "mpc11") (:form . "MPC11") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "t(12;15)") (:form . "t(12;15)") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 124) (:start . 111) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 143) (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "hybrid") (:form . "hybrids") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "unfused") (:form . "unfused") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 189)\n  (:start . 178) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1040.8) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009715@unknown@formal@none@1@S@Therefore, inactivation of the IgH 3' enhancer is a multifactorial process affecting several transcription factors that control the cell-specific and developmental activity of the enhancer.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multifactorial") (:form . "multifactorial")\n  (:end . 66) (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 145) (:start . 132) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 163) (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 172)\n  (:start . 164) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 188)\n  (:start . 180) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1040.9) (:did . :|9188842|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009716@unknown@formal@none@1@S@ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter.@(((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 38) (:start . 23) (:id . 47))\n ((:tag . "VBP") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1041.1) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009717@unknown@formal@none@1@S@Activation of helper T cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 114) (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 129) (:start . 116) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "haematopoietic") (:form . "haematopoietic")\n  (:end . 166) (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 173)\n  (:start . 167) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1041.2) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009718@unknown@formal@none@1@S@Granulocyte-macrophage colony stimulating factor (GM-CSF) is one such cytokine, whose increased expression results mostly from increases in transcription.@(((:tag . "JJ") (:stem . "granulocyte-macrophage")\n  (:form . "Granulocyte-macrophage") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 29)\n  (:start . 23) (:id . 43))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 41)\n  (:start . 30) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 56)\n  (:start . 50) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1041.3) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009720@unknown@formal@none@1@S@ETS1 is a transcription factor of the ETS family that is expressed in T cells.@(((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ETS") (:form . "ETS") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1041.5) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009721@unknown@formal@none@1@S@We have previously shown that ETS1 can transactivate GM-CSF in Jurkat T cells, but only after the cells have been stimulated by treatment with PMA and ionomycin, agents that mimic T cell activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 160)\n  (:start . 151) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 168)\n  (:start . 162) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "mimic") (:form . "mimic") (:end . 179)\n  (:start . 174) (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 197)\n  (:start . 187) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1041.6) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009722@unknown@formal@none@1@S@Thus we proposed that ETS1, which is expressed constitutively in Jurkat cells, may act in concert with PMA/ionomycin inducible factors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "propose") (:form . "proposed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 61) (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PMA/ionomycin") (:form . "PMA/ionomycin")\n  (:end . 116) (:start . 103) (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1041.7.1) (:span 79 82)) ((:id . :x1041.7.2) (:span 8 16)))\n (:hscopes ((:id . :x1041.7.1) (:span 79 134))\n  ((:id . :x1041.7.2) (:span 8 134)))\n (:identifiers (:sid . :s1041.7) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009723@unknown@formal@none@1@S@Here we show that ETS1 can transactivate a GM-CSF reporter construct in unstimulated Jurkat cells, providing that either NFkappaB or AP1 transcription factors are supplied by co-transfection.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ets1") (:form . "ETS1") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 40) (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ap1") (:form . "AP1") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 150) (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "supply") (:form . "supplied") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "co-transfection") (:form . "co-transfection")\n  (:end . 190) (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1041.8) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009724@unknown@formal@none@1@S@We confirm that binding of endogenous NFkappaB and AP1 is induced following PMA/ionomycin treatment of T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "confirm") (:form . "confirm") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NNP") (:stem . "PMA/ionomycin") (:form . "PMA/ionomycin")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1041.9) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009725@unknown@formal@none@1@S@Transactivation by ETS1, NFkappaB and AP1 is synergistic, and mutation of the individual binding sites reveals that the transcriptional activities of these factors are interdependent.@(((:tag . "NNP") (:stem . "Transactivation") (:form . "Transactivation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ETS1") (:form . "ETS1") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 135) (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "interdependent") (:form . "interdependent")\n  (:end . 182) (:start . 168) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1041.10) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009726@unknown@formal@none@1@S@Our results suggest that constitutive ETS1, and inducible NFkappaB and AP1, cooperate as part of a higher order transcriptional complex in activated T cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "ets1") (:form . "ETS1") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AP1") (:form . "AP1") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 127) (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1041.11.1) (:span 12 19)))\n (:hscopes ((:id . :x1041.11.1) (:span 12 156)))\n (:identifiers (:sid . :s1041.11) (:did . :|9190901|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009727@unknown@formal@none@1@S@The IL-4 receptor alpha-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "alpha-chain") (:form . "alpha-chain") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "JAK-1") (:form . "JAK-1") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "il-4-specific") (:form . "IL-4-specific")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1042.1) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009728@unknown@formal@none@1@S@The common gamma-chain (gamma(c)) is a functional component of the IL-4R, yet cells lacking gamma(c) are able to respond to IL-4.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gamma-chain") (:form . "gamma-chain") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "gamma(c))") (:form . "gamma(c))") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4r") (:form . "IL-4R") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "gamma(c)") (:form . "gamma(c)") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "VB") (:stem . "respond") (:form . "respond") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 128) (:start . 124)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1042.2.1) (:span 84 91)))\n (:nscopes ((:id . :x1042.2.1) (:span 84 100)))\n (:identifiers (:sid . :s1042.2) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009730@unknown@formal@none@1@S@An alternative possibility is that in the absence of gamma(c), the IL-4R alpha chain is able to transduce signals by homodimerization.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "gamma(c)") (:form . "gamma(c)") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "homodimerization") (:form . "homodimerization")\n  (:end . 133) (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1042.4.2) (:span 15 26)))\n (:ncues ((:id . :x1042.4.1) (:span 42 49)))\n (:hscopes ((:id . :x1042.4.2) (:span 15 133)))\n (:nscopes ((:id . :x1042.4.1) (:span 42 61)))\n (:identifiers (:sid . :s1042.4) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009731@unknown@formal@none@1@S@To test this latter possibility, a chimeric receptor containing the extracellular domain of c-kit (the stem cell factor (SCF) receptor) and the cytoplasmic and transmembrane domains of the IL-4R alpha chain was generated.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-kit") (:form . "c-kit") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "SCF") (:form . "SCF") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 155)\n  (:start . 144) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 173) (:start . 160) (:id . 71))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 181)\n  (:start . 174) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 194)\n  (:start . 189) (:id . 75))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 200)\n  (:start . 195) (:id . 76))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 206)\n  (:start . 201) (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 210) (:start . 207)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 220)\n  (:start . 211) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1042.5) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009732@unknown@formal@none@1@S@Treatment of cells expressing the chimeric receptor kit/IL-4R alpha with SCF induces activation of the IL-4R alpha-associated kinase JAK-1 and the transcription factor STAT6.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "kit/IL-4R") (:form . "kit/IL-4R") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SCF") (:form . "SCF") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4r") (:form . "IL-4R") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "JJ") (:stem . "alpha-associated") (:form . "alpha-associated")\n  (:end . 125) (:start . 109) (:id . 58))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "NNP") (:stem . "JAK-1") (:form . "JAK-1") (:end . 138)\n  (:start . 133) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 160) (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 167)\n  (:start . 161) (:id . 64))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 173)\n  (:start . 168) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1042.6) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009733@unknown@formal@none@1@S@However, tyrosine phosphorylation of JAK-3, which associates with gamma(c), is not induced by SCF in these cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "JAK-3") (:form . "JAK-3") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "gamma(c)") (:form . "gamma(c)") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "SCF") (:form . "SCF") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1042.7.1) (:span 79 82)))\n (:nscopes ((:id . :x1042.7.1) (:span 9 112)))\n (:identifiers (:sid . :s1042.7) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009734@unknown@formal@none@1@S@SCF-mediated ligation of kit/IL-4R alpha is sufficient to elicit IL-4-specific gene expression, including up-regulation of CD23 and synthesis of germ-line epsilon transcripts.@(((:tag . "JJ") (:stem . "scf-mediated") (:form . "SCF-mediated") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "kit/IL-4R") (:form . "kit/IL-4R") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VB") (:stem . "elicit") (:form . "elicit") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "il-4-specific") (:form . "IL-4-specific")\n  (:end . 78) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 105)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 119) (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd23") (:form . "CD23") (:end . 127) (:start . 123)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 141)\n  (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "germ-line") (:form . "germ-line") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 162)\n  (:start . 155) (:id . 63))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 174)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1042.8) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009735@unknown@formal@none@1@S@In the T cell line CTLL2, ligation of kit/IL-4R alpha induces cellular proliferation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ctll2") (:form . "CTLL2") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 34)\n  (:start . 26) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "kit/IL-4R") (:form . "kit/IL-4R") (:end . 47)\n  (:start . 38) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 84) (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1042.9) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009736@unknown@formal@none@1@S@Finally, in JAK-1-deficient HeLa cells, STAT6 activation by IL-4 is completely abolished.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "jak-1-deficient") (:form . "JAK-1-deficient")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1042.10) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009737@unknown@formal@none@1@S@Together, these data demonstrate that the IL-4R alpha cytoplasmic domain is sufficient to activate JAK-1 and STAT6 and to induce expression of IL-4 target genes, thus identifying a mechanism by which IL-4 signaling can proceed in the absence of JAK-3 and gamma(c).@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-4R") (:form . "IL-4R") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "NNP") (:stem . "JAK-1") (:form . "JAK-1") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 160)\n  (:start . 155) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 178)\n  (:start . 167) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 190)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 199)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 204) (:start . 200)\n  (:id . 75))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 214)\n  (:start . 205) (:id . 76))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 218) (:start . 215)\n  (:id . 77))\n ((:tag . "VB") (:stem . "proceed") (:form . "proceed") (:end . 226)\n  (:start . 219) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 233) (:start . 230)\n  (:id . 80))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 241)\n  (:start . 234) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 244) (:start . 242)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "JAK-3") (:form . "JAK-3") (:end . 250)\n  (:start . 245) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 254) (:start . 251)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "gamma(c)") (:form . "gamma(c)") (:end . 263)\n  (:start . 255) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x1042.11.1) (:span 234 241)))\n (:nscopes ((:id . :x1042.11.1) (:span 234 263)))\n (:identifiers (:sid . :s1042.11) (:did . :|9190938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009738@unknown@formal@none@1@S@Relief of cyclin A gene transcriptional inhibition during activation of human primary T lymphocytes via CD2 and CD28 adhesion molecules.@(((:tag . "NNP") (:stem . "Relief") (:form . "Relief") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 39) (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1043.1) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009740@unknown@formal@none@1@S@To understand the mechanisms underlined in this regulation in normal human cells, we have analysed in vivo protein-DNA interactions at the Cyclin A locus in primary T lymphocytes.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "underline") (:form . "underlined") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 118)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 131)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Cyclin") (:form . "Cyclin") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 178)\n  (:start . 167) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1043.3) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009741@unknown@formal@none@1@S@Stimulation of purified T lymphocytes by a combination of monoclonal antibodies directed at CD2 and CD28 adhesion molecules gives rise to a long lasting proliferation in the absence of accessory cells.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "VBZ") (:stem . "give") (:form . "gives") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lasting") (:form . "lasting") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 166) (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "NN") (:stem . "accessory") (:form . "accessory") (:end . 194)\n  (:start . 185) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 200)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1043.4.1) (:span 174 181)))\n (:nscopes ((:id . :x1043.4.1) (:span 174 200)))\n (:identifiers (:sid . :s1043.4) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009742@unknown@formal@none@1@S@Cyclin A was observed after 4 days of costimulation with anti CD2 + CD28 whereas stimulation by anti CD2 or anti CD28 alone was not effective.@(((:tag . "NNP") (:stem . "Cyclin") (:form . "Cyclin") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 51) (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1043.5.1) (:span 128 131)))\n (:nscopes ((:id . :x1043.5.1) (:span 128 141)))\n (:identifiers (:sid . :s1043.5) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009743@unknown@formal@none@1@S@In vivo genomic DMS footprinting revealed upstream of the major transcription initiation sites, the presence of at least three protein binding sites, two of which were constitutively occupied.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "DMS") (:form . "DMS") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 182) (:start . 168) (:id . 70))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 191)\n  (:start . 183) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1043.6) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009744@unknown@formal@none@1@S@They bind in vitro respectively ATF-1 and NF-Y proteins.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "atf-1") (:form . "ATF-1") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nf-y") (:form . "NF-Y") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1043.7) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009745@unknown@formal@none@1@S@The third site was occupied in quiescent cells or in cells stimulated by anti CD2 or anti CD28 alone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1043.8) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009746@unknown@formal@none@1@S@The mitogenic combination of anti CD2 + anti CD28 released the footprint as cells were committed to proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "release") (:form . "released") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "footprint") (:form . "footprint") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "commit") (:form . "committed") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 113) (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1043.9) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009747@unknown@formal@none@1@S@Consistent with theses results, nuclear extracts prepared from quiescent cells formed a specific complex with this element, whereas extracts prepared from cells treated with anti CD2 + anti CD28 failed to do so after cells entered a proliferative state.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "theses") (:form . "theses") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 85) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 168)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 182) (:start . 179)\n  (:id . 69))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "anti") (:form . "anti") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 194) (:start . 190)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 210) (:start . 208)\n  (:id . 76))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 216)\n  (:start . 211) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 222)\n  (:start . 217) (:id . 78))\n ((:tag . "VBD") (:stem . "enter") (:form . "entered") (:end . 230)\n  (:start . 223) (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 232) (:start . 231)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 246) (:start . 233) (:id . 81))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 252)\n  (:start . 247) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x1043.10.1) (:span 195 201)))\n (:nscopes ((:id . :x1043.10.1) (:span 195 252)))\n (:identifiers (:sid . :s1043.10) (:did . :|9191057|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009748@unknown@formal@none@1@S@Interleukin-10 inhibits interferon-gamma-induced intercellular adhesion molecule-1 gene transcription in human monocytes.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "JJ") (:stem . "interferon-gamma-induced")\n  (:form . "interferon-gamma-induced") (:end . 48) (:start . 24) (:id . 44))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 62) (:start . 49) (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 71)\n  (:start . 63) (:id . 46))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 82)\n  (:start . 72) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 120)\n  (:start . 111) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1044.1) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009750@unknown@formal@none@1@S@In this study, we investigated the mechanism by which IL-10 downregulates expression of intercellular adhesion molecule-1 (ICAM-1) on the cell surface of normal human monocytes activated with interferon-gamma (IFN-gamma).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "downregulate") (:form . "downregulates")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 129)\n  (:start . 123) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 160)\n  (:start . 154) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 166)\n  (:start . 161) (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 176)\n  (:start . 167) (:id . 69))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 186)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 208) (:start . 192) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 219)\n  (:start . 210) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1044.3) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009751@unknown@formal@none@1@S@IL-10 inhibition of IFN-gamma-induced ICAM-1 expression was apparent as early as 3 hours and was blocked by an anti-IL-10 antibody but not by an isotype-matched control antibody.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 37) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 44)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-il-10") (:form . "anti-IL-10") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "isotype-matched") (:form . "isotype-matched")\n  (:end . 160) (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 168)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1044.4.1) (:span 135 138)))\n (:nscopes ((:id . :x1044.4.1) (:span 135 177)))\n (:identifiers (:sid . :s1044.4) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009752@unknown@formal@none@1@S@Northern blot analysis showed that IL-10 reduced the accumulation of ICAM-1 mRNA in IFN-gamma-stimulated monocytes.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ifn-gamma-stimulated")\n  (:form . "IFN-gamma-stimulated") (:end . 104) (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1044.5) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009753@unknown@formal@none@1@S@IL-10 inhibition of ICAM-1 steady-state mRNA was detected at 3 hours and remained at 24 hours.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1044.6) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009754@unknown@formal@none@1@S@Nuclear run-on transcription assays showed that IL-10 inhibited the rate of IFN-gamma-induced transcription of the ICAM-1 gene, and mRNA stability studies showed that IL-10 did not alter the half-life of IFN-gamma-induced ICAM-1 message.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-on") (:form . "run-on") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 42) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 93) (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 161)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 186)\n  (:start . 181) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 70))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 200)\n  (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 221) (:start . 204) (:id . 73))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 228)\n  (:start . 222) (:id . 74))\n ((:tag . "NN") (:stem . "message") (:form . "message") (:end . 236)\n  (:start . 229) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1044.7.1) (:span 177 180)))\n (:nscopes ((:id . :x1044.7.1) (:span 177 236)))\n (:identifiers (:sid . :s1044.7) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009755@unknown@formal@none@1@S@Thus, IL-10 inhibits IFN-gamma-induced ICAM-1 expression in monocytes primarily at the level of gene transcription.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 38) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1044.8) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009756@unknown@formal@none@1@S@Activation of IFN-gamma-responsive genes requires tyrosine phosphorylation of the transcriptional factor STAT-1alpha (signal transducer and activator of transcription-1alpha).@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "ifn-gamma-responsive")\n  (:form . "IFN-gamma-responsive") (:end . 34) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 40) (:start . 35)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 58)\n  (:start . 50) (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 74) (:start . 59) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 97) (:start . 82) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 52))\n ((:tag . "NNP") (:stem . "STAT-1alpha") (:form . "STAT-1alpha") (:end . 116)\n  (:start . 105) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 124)\n  (:start . 118) (:id . 55))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 135)\n  (:start . 125) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 149)\n  (:start . 140) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription-1alpha")\n  (:form . "transcription-1alpha") (:end . 173) (:start . 153) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1044.9) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009757@unknown@formal@none@1@S@However, IL-10 did not affect IFN-gamma-induced tyrosine phosphorylation of STAT-1alpha or alter STAT-1alpha binding to the IFN-gamma response element (IRE) in the ICAM-1 promoter.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 47) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 72) (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT-1alpha") (:form . "STAT-1alpha") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 96) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT-1alpha") (:form . "STAT-1alpha") (:end . 108)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 142)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 150)\n  (:start . 143) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IRE") (:form . "IRE") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 179)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1044.10.1) (:span 19 22)))\n (:nscopes ((:id . :x1044.10.1) (:span 19 179)))\n (:identifiers (:sid . :s1044.10) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009758@unknown@formal@none@1@S@Instead, IL-10 prevented IFN-gamma-induced binding activity at the NF-kappaB site of the tumor necrosis factor alpha (TNF-alpha)-responsive NF-kappaB/C-EBP composite element in the ICAM-1 promoter.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 42) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha)-responsive")\n  (:form . "TNF-alpha)-responsive") (:end . 139) (:start . 118) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB/C-EBP") (:form . "NF-kappaB/C-EBP")\n  (:end . 155) (:start . 140) (:id . 61))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 165)\n  (:start . 156) (:id . 62))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 173)\n  (:start . 166) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 65))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 187)\n  (:start . 181) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 196)\n  (:start . 188) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1044.11) (:did . :|9192770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009760@unknown@formal@none@1@S@Biphasic control of NF-kappa B activation induced by the triggering of HLA-DR antigens expressed on B cells.@(((:tag . "JJ") (:stem . "biphasic") (:form . "Biphasic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1045.1) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009761@unknown@formal@none@1@S@The regulation of NF-kappa B activation following the triggering of HLA-DR antigens by mAb L243 has been studied at various times in Raji cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "l243") (:form . "L243") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1045.2) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009762@unknown@formal@none@1@S@Electrophoretic mobility shift assays demonstrated a strong increase of NF-kappa B DNA binding after triggering of HLA-DR antigens.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 50)\n  (:start . 38) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1045.3) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009763@unknown@formal@none@1@S@Using TNF-alpha-activity neutralizing antibodies, the authors demonstrated that the upregulation of NF-kappa B was found to depend, at later time point, on an autocrine effect of TNF-alpha secreted following triggering of HLA-DR antigens.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tnf-alpha-activity") (:form . "TNF-alpha-activity")\n  (:end . 24) (:start . 6) (:id . 43))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 37)\n  (:start . 25) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 48)\n  (:start . 38) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 74)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 96)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 108)\n  (:start . 100) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 120)\n  (:start . 115) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "late") (:form . "later") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 151)\n  (:start . 146) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 168)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 188)\n  (:start . 179) (:id . 71))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 197)\n  (:start . 189) (:id . 72))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 207)\n  (:start . 198) (:id . 73))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 218)\n  (:start . 208) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 228)\n  (:start . 222) (:id . 76))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 237)\n  (:start . 229) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1045.4) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009764@unknown@formal@none@1@S@In contrast, it was found to be TNF-alpha independent in the early time point.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 41)\n  (:start . 32) (:id . 50))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 53)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1045.5) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009765@unknown@formal@none@1@S@Moreover, the upregulation of NF-kappa B binding activity is regulated by the triggering of selected epitopes of HLA-DR antigens.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "epitope") (:form . "epitopes") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HLA-DR") (:form . "HLA-DR") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1045.6) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009766@unknown@formal@none@1@S@In fact, mAb L243 but not the staphylococcal superantigens, staphylococcal exotoxin toxic shock syndrome toxin-I or staphylococcal enterotoxin B, regulate the NF-kappa B binding activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "l243") (:form . "L243") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 44) (:start . 30) (:id . 50))\n ((:tag . "NNS") (:stem . "superantigen") (:form . "superantigens")\n  (:end . 58) (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 74) (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "exotoxin") (:form . "exotoxin") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "toxic") (:form . "toxic") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "toxin-i") (:form . "toxin-I") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "staphylococcal") (:form . "staphylococcal")\n  (:end . 130) (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "enterotoxin") (:form . "enterotoxin") (:end . 142)\n  (:start . 131) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1045.7.1) (:span 22 25)))\n (:nscopes ((:id . :x1045.7.1) (:span 22 58)))\n (:identifiers (:sid . :s1045.7) (:did . :|9195127|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009767@unknown@formal@none@1@S@Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1046.1) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009768@unknown@formal@none@1@S@Stat (signal transducers and activators of transcription) and Jak (Janus kinases) proteins are central components in the signal transduction events in hematopoietic and epithelial cells.@(((:tag . "NN") (:stem . "stat") (:form . "Stat") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jak") (:form . "Jak") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 140)\n  (:start . 128) (:id . 64))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 164) (:start . 151) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 179)\n  (:start . 169) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1046.2) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009770@unknown@formal@none@1@S@Upon ligand binding and cytokine receptor dimerization, Stat proteins are phosphorylated on tyrosine residues by Jak kinases.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Stat") (:form . "Stat") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 88) (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jak") (:form . "Jak") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1046.4) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009771@unknown@formal@none@1@S@Activated Stat proteins form homo- or heterodimers, translocate to the nucleus, and induce transcription from responsive genes.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stat") (:form . "Stat") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "homo-") (:form . "homo-") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 50)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "translocate") (:form . "translocate") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1046.5) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009772@unknown@formal@none@1@S@Stat5 and Stat6 are transcription factors active in mammary epithelial cells and immune cells.@(((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1046.6) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009773@unknown@formal@none@1@S@Prolactin activates Stat5, and interleukin-4 (IL-4) activates Stat6.@(((:tag . "NNP") (:stem . "Prolactin") (:form . "Prolactin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "stat5") (:form . "Stat5") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1046.7) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009774@unknown@formal@none@1@S@Both cytokines are able to stimulate cell proliferation, differentiation, and survival.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1046.8) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009775@unknown@formal@none@1@S@We investigated the transactivation potential of Stat6 and found that it is not restricted to lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 35) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "restrict") (:form . "restricted") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1046.9.1) (:span 76 79)))\n (:nscopes ((:id . :x1046.9.1) (:span 76 105)))\n (:identifiers (:sid . :s1046.9) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009776@unknown@formal@none@1@S@IL-4-dependent activation of Stat6 was also observed in HC11 mammary epithelial cells.@(((:tag . "JJ") (:stem . "il-4-dependent") (:form . "IL-4-dependent")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hc11") (:form . "HC11") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mammary") (:form . "mammary") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1046.10) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009777@unknown@formal@none@1@S@In these cells, Stat6 activation led to the induction of the beta-casein gene promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 72)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1046.11) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009778@unknown@formal@none@1@S@The induction of this promoter was confirmed in COS7 cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cos7") (:form . "COS7") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1046.12) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009780@unknown@formal@none@1@S@Deletion analysis of the carboxyl-terminal region of Stat6 and recombination of this region with a heterologous DNA binding domain allowed the delimitation and characterization of the transactivation domain of Stat6.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 42) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 111)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "delimitation") (:form . "delimitation") (:end . 155)\n  (:start . 143) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 176) (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 199) (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 206)\n  (:start . 200) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 215)\n  (:start . 210) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1046.14) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009781@unknown@formal@none@1@S@The potencies of the transactivation domains of Stat5, Stat6, and viral protein VP16 were compared.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "potency") (:form . "potencies") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 36) (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "vp16") (:form . "VP16") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1046.15) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009782@unknown@formal@none@1@S@Stat6 had a transactivation domain which was about 10-fold stronger than that of Stat5.@(((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "10-fold") (:form . "10-fold") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1046.16) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009783@unknown@formal@none@1@S@In pre-B cells (Ba/F3), the transactivation domain of Stat6 was IL-4 regulated, independently from its DNA binding function.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ba/F3") (:form . "Ba/F3") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 43) (:start . 28) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 93) (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1046.17) (:did . :|9199300|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009784@unknown@formal@none@1@S@The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 72) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 109)\n  (:start . 102) (:id . 54))\n ((:tag . "JJ") (:stem . "noncanonical") (:form . "noncanonical") (:end . 122)\n  (:start . 110) (:id . 55))\n ((:tag . "NNP") (:stem . "Egr") (:form . "Egr") (:end . 126) (:start . 123)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 134) (:start . 131)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 59))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 148)\n  (:start . 143) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1047.1) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009785@unknown@formal@none@1@S@The interleukin-2 IL-2 receptor beta-chain (IL-2Rbeta) is an essential component of the receptors for IL-2 and IL-15.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "beta-chain") (:form . "beta-chain") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2Rbeta") (:form . "IL-2Rbeta") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-15") (:form . "IL-15") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1047.2) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009786@unknown@formal@none@1@S@Although IL-2Rbeta is constitutively expressed by lymphocytes, its expression can be further induced by a number of stimuli, including phorbol 12-myristate 13-acetate (PMA).@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IL-2Rbeta") (:form . "IL-2Rbeta") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 36) (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 166)\n  (:start . 156) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1047.3) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009787@unknown@formal@none@1@S@We have now characterized factors that bind to an enhancer region located between nucleotides -170 and -139 of the human IL-2Rbeta promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "CD") (:stem . "-170") (:form . "-170") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-139") (:form . "-139") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NNP") (:stem . "IL-2Rbeta") (:form . "IL-2Rbeta") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1047.4) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009788@unknown@formal@none@1@S@Both Sp1 and Sp3 bound to the 5' portion of this region, whereas a PMA-inducible factor (PIF) mainly bound to its 3' portion and bound to the Sp binding motifs as well.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sp3") (:form . "Sp3") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 40)\n  (:start . 33) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 55)\n  (:start . 49) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 64)\n  (:start . 57) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "pma-inducible") (:form . "PMA-inducible")\n  (:end . 80) (:start . 67) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 87)\n  (:start . 81) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PIF") (:form . "PIF") (:end . 92) (:start . 89)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 62))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 100)\n  (:start . 94) (:id . 63))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 106)\n  (:start . 101) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 113) (:start . 110)\n  (:id . 66))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 115) (:start . 114)\n  (:id . 67))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 116) (:start . 115)\n  (:id . 68))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 124)\n  (:start . 117) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 134)\n  (:start . 129) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Sp") (:form . "Sp") (:end . 144) (:start . 142)\n  (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 152)\n  (:start . 145) (:id . 75))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 159)\n  (:start . 153) (:id . 76))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 162) (:start . 160)\n  (:id . 77))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 167) (:start . 163)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1047.5) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009790@unknown@formal@none@1@S@Interestingly, PIF was constitutively activated in human T-cell leukemia virus type 1-transformed MT-2 cells.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PIF") (:form . "PIF") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "1-transformed") (:form . "1-transformed")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "mt-2") (:form . "MT-2") (:end . 102) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1047.7) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009791@unknown@formal@none@1@S@In this paper, we demonstrate that PIF is Egr-1 based on its recognition by anti-Egr-1 antisera in gel mobility shift assays, even though the IL-2Rbeta DNA binding motif differed substantially from the canonical Egr-1 binding site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PIF") (:form . "PIF") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 72)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-egr-1") (:form . "anti-Egr-1") (:end . 86)\n  (:start . 76) (:id . 57))\n ((:tag . "NNS") (:stem . "antiserum") (:form . "antisera") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 137)\n  (:start . 131) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IL-2Rbeta") (:form . "IL-2Rbeta") (:end . 151)\n  (:start . 142) (:id . 68))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 163)\n  (:start . 156) (:id . 70))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 169)\n  (:start . 164) (:id . 71))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 178)\n  (:start . 170) (:id . 72))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 192) (:start . 179) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 217)\n  (:start . 212) (:id . 77))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 225)\n  (:start . 218) (:id . 78))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 230) (:start . 226)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1047.8) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009792@unknown@formal@none@1@S@In addition, Egr-1 bound to the Sp binding site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Sp") (:form . "Sp") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1047.9) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009793@unknown@formal@none@1@S@In Jurkat cells, both sites were required for maximal IL-2Rbeta promoter activity, and in HeLaS3 cells, transfection of Egr-1 could drive activity of a reporter construct containing both sites.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NNP") (:stem . "IL-2Rbeta") (:form . "IL-2Rbeta") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "helas3") (:form . "HeLaS3") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 116)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 160)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 181)\n  (:start . 171) (:id . 71))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 186) (:start . 182)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 192)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1047.10) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009794@unknown@formal@none@1@S@Moreover, Sp1 and Egr-1 could form a complex with kinetics that correlated with the production of Egr-1 in Jurkat cells upon PMA stimulation.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 140)\n  (:start . 129) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1047.11) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009795@unknown@formal@none@1@S@Thus, Sp1 and Egr-1 physically and functionally cooperate to mediate maximal IL-2Rbeta promoter activity.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 47)\n  (:start . 35) (:id . 49))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2Rbeta") (:form . "IL-2Rbeta") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1047.12) (:did . :|9199305|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009796@unknown@formal@none@1@S@Anti-Ehrlichia chaffeensis antibody complexed with E. chaffeensis induces potent proinflammatory cytokine mRNA expression in human monocytes through sustained reduction of IkappaB-alpha and activation of NF-kappaB.@(((:tag . "FW") (:stem . "anti-ehrlichia") (:form . "Anti-Ehrlichia")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 26)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 35)\n  (:start . 27) (:id . 44))\n ((:tag . "VBN") (:stem . "complexe") (:form . "complexed") (:end . 45)\n  (:start . 36) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 46))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 65)\n  (:start . 54) (:id . 48))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 80)\n  (:start . 74) (:id . 50))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 96) (:start . 81) (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 105)\n  (:start . 97) (:id . 52))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 110) (:start . 106)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 130)\n  (:start . 125) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 140)\n  (:start . 131) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 148)\n  (:start . 141) (:id . 58))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 158)\n  (:start . 149) (:id . 59))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 168)\n  (:start . 159) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 185) (:start . 172) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 200)\n  (:start . 190) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 213)\n  (:start . 204) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1048.1) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009797@unknown@formal@none@1@S@Ehrlichia chaffeensis is an obligatory intracellular bacterium that infects monocytes and macrophages and is the etiologic agent of human ehrlichiosis in the United States.@(((:tag . "FW") (:stem . "ehrlichia") (:form . "Ehrlichia") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 52) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "bacterium") (:form . "bacterium") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "infect") (:form . "infects") (:end . 75)\n  (:start . 68) (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 85)\n  (:start . 76) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 101)\n  (:start . 90) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "etiologic") (:form . "etiologic") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 128)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "ehrlichiosis") (:form . "ehrlichiosis") (:end . 150)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 164)\n  (:start . 158) (:id . 64))\n ((:tag . "NNPS") (:stem . "State") (:form . "States") (:end . 171)\n  (:start . 165) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1048.2) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009798@unknown@formal@none@1@S@Our previous studies showed that the exposure of human monocytes to E. chaffeensis induces the expression of interleukin-1beta (IL-1beta), IL-8, and IL-10 genes in vitro but not the expression of tumor necrosis factor alpha (TNF-alpha) and IL-6 mRNAs.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 27) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 126) (:start . 109) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 160)\n  (:start . 155) (:id . 68))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 169)\n  (:start . 164) (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 192)\n  (:start . 182) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 201)\n  (:start . 196) (:id . 76))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 210)\n  (:start . 202) (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 217)\n  (:start . 211) (:id . 78))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 223)\n  (:start . 218) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 225) (:start . 224)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 234)\n  (:start . 225) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 235) (:start . 234)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 244) (:start . 240)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 250)\n  (:start . 245) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x1048.3.1) (:span 174 177)))\n (:nscopes ((:id . :x1048.3.1) (:span 174 250)))\n (:identifiers (:sid . :s1048.3) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009800@unknown@formal@none@1@S@Human monocytic cell line THP-1 was treated with E. chaffeensis which had been preincubated with human anti-E. chaffeensis serum for 2 h, and the levels of cytokine mRNAs were evaluated by competitive reverse transcription-PCR.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "preincubate") (:form . "preincubated") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "FW") (:stem . "anti-e.") (:form . "anti-E.") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 122)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 152)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 164)\n  (:start . 156) (:id . 69))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 185)\n  (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 200)\n  (:start . 189) (:id . 74))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 208)\n  (:start . 201) (:id . 75))\n ((:tag . "NNP") (:stem . "transcription-PCR") (:form . "transcription-PCR")\n  (:end . 226) (:start . 209) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1048.5) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009801@unknown@formal@none@1@S@Anti-E. chaffeensis antibody complexed with E. chaffeensis significantly enhanced mRNA expression of IL-1beta in THP-1 cells.@(((:tag . "FW") (:stem . "anti-e.") (:form . "Anti-E.") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "VBN") (:stem . "complexe") (:form . "complexed") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 58)\n  (:start . 47) (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 72) (:start . 59) (:id . 49))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 81)\n  (:start . 73) (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 86) (:start . 82)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 118)\n  (:start . 113) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1048.6) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009802@unknown@formal@none@1@S@The expression of TNF-alpha and IL-6 mRNAs was also induced.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1048.7) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009803@unknown@formal@none@1@S@The levels of secreted IL-1beta, TNF-alpha, and IL-6 during 24 h of stimulation were comparable to those induced by Escherichia coli lipopolysaccharide at 1 microg/ml.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 79)\n  (:start . 68) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 95)\n  (:start . 85) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "FW") (:stem . "escherichia") (:form . "Escherichia") (:end . 127)\n  (:start . 116) (:id . 63))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 151) (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "microg/ml") (:form . "microg/ml") (:end . 166)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1048.8) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009804@unknown@formal@none@1@S@Fab fragment of anti-E. chaffeensis immunoglobulin G complexed with E. chaffeensis did not induce any of these three cytokines, indicating that ehrlichial binding is required for IL-1beta mRNA expression and that binding of the immune complex to the Fc gamma receptor is required for TNF-alpha and IL-6 mRNA expression and enhanced IL-1beta mRNA expression.@(((:tag . "NNP") (:stem . "Fab") (:form . "Fab") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "anti-e.") (:form . "anti-E.") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 50) (:start . 36) (:id . 47))\n ((:tag . 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5009805@unknown@formal@none@1@S@Furthermore, prolonged degradation of IkappaB-alpha and activation of NF-kappaB were demonstrated in THP-1 cells exposed to anti-E. chaffeensis serum and E. chaffeensis.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 51) (:start . 38) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 97)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "FW") (:stem . "anti-e.") (:form . "anti-E.") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 143)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 168)\n  (:start . 157) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1048.10) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009806@unknown@formal@none@1@S@This result implies that development of anti-E. chaffeensis antibody in patients can result in the production of major proinflammatory cytokines, which may play an important role in the pathophysiology of ehrlichiosis and immune responses to it.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "FW") (:stem . "anti-e.") (:form . "anti-E.") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "FW") (:stem . "chaffeensis") (:form . "chaffeensis") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 134) (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 144)\n  (:start . 135) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 160) (:start . 156)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 173)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 201) (:start . 186) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ehrlichiosis") (:form . "ehrlichiosis") (:end . 217)\n  (:start . 205) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 228)\n  (:start . 222) (:id . 75))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 238)\n  (:start . 229) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 241) (:start . 239)\n  (:id . 77))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 244) (:start . 242)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1048.11.1) (:span 152 155))\n  ((:id . :x1048.11.2) (:span 12 19)))\n (:hscopes ((:id . :x1048.11.1) (:span 152 244))\n  ((:id . :x1048.11.2) (:span 12 244)))\n (:identifiers (:sid . :s1048.11) (:did . :|9199464|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009807@unknown@formal@none@1@S@S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells.@(((:tag . "JJ") (:stem . "s-allyl") (:form . "S-allyl") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1049.1) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009808@unknown@formal@none@1@S@Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription.@(((:tag . "JJ") (:stem . "reactive") (:form . "Reactive") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 152)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 192) (:start . 179) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1049.2) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009810@unknown@formal@none@1@S@In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SAC") (:form . "SAC") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 94)\n  (:start . 83) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 117)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 126)\n  (:start . 121) (:id . 65))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 67))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "tnf-") (:form . "TNF-") (:end . 154) (:start . 150)\n  (:id . 70))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 170) (:start . 166)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1049.4) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009811@unknown@formal@none@1@S@Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 75) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "32p-labeled") (:form . "32P-labeled") (:end . 114)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1049.5) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009812@unknown@formal@none@1@S@SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2.@(((:tag . "NN") (:stem . "sac") (:form . "SAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 43) (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 54)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 105)\n  (:start . 96) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "H2O2") (:form . "H2O2") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1049.6) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009813@unknown@formal@none@1@S@Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein.@(((:tag . "NNP") (:stem . "Supershift") (:form . "Supershift") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "VBN") (:stem . "retard") (:form . "retarded") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "band") (:form . "bands") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65-p50") (:form . "p65-p50") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 147)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 163)\n  (:start . 155) (:id . 65))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 169)\n  (:start . 164) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1049.7) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009814@unknown@formal@none@1@S@Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SAC") (:form . "SAC") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1049.8.1) (:span 26 29)) ((:id . :x1049.8.2) (:span 9 16)))\n (:hscopes ((:id . :x1049.8.1) (:span 26 107))\n  ((:id . :x1049.8.2) (:span 9 107)))\n (:identifiers (:sid . :s1049.8) (:did . :|9199898|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009815@unknown@formal@none@1@S@Effect of adenovirus 2 on cellular gene activation in blood-derived monocytes and macrophages.@(((:tag . "NN") (:stem . "effect") (:form . "Effect") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "blood-derived") (:form . "blood-derived")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1050.1) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009816@unknown@formal@none@1@S@We have investigated the effect of adenovirus 2 (Ad2) infection on human monocytes and monocyte-derived macrophages with regard to expression of TNF-alpha and IL-1 beta.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ad2") (:form . "Ad2") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 103) (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "regard") (:form . "regard") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 154)\n  (:start . 145) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1050.2) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009817@unknown@formal@none@1@S@In monocytes, the virus was bound to the surface without being internalized.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "internalize") (:form . "internalized") (:end . 75)\n  (:start . 63) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1050.3.1) (:span 49 56)))\n (:nscopes ((:id . :x1050.3.1) (:span 49 75)))\n (:identifiers (:sid . :s1050.3) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009818@unknown@formal@none@1@S@On the other hand, Ad2 was internalized by macrophages.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ad2") (:form . "Ad2") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "internalize") (:form . "internalized") (:end . 39)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1050.4) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009820@unknown@formal@none@1@S@Ad2 infection induced transient increase in the mRNA levels for TNF-alpha and IL-1 beta in both monocytes and in macrophages, although the kinetics of the transcription was slightly different.@(((:tag . "NN") (:stem . "ad2") (:form . "Ad2") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 181)\n  (:start . 173) (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 191)\n  (:start . 182) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1050.6) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009821@unknown@formal@none@1@S@The production of both cytokines, measured by ELISA tests, was enhanced in monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "test") (:form . "tests") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1050.7) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009822@unknown@formal@none@1@S@In macrophages, a slight enhancement of TNF-alpha production was seen, whereas IL-1 beta was not detected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1050.8.1) (:span 93 96)))\n (:nscopes ((:id . :x1050.8.1) (:span 79 105)))\n (:identifiers (:sid . :s1050.8) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009823@unknown@formal@none@1@S@The data indicate that cellular genes might be activated by Ad2 virus infection in nonpermissive cells where no viral gene products could be detected.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ad2") (:form . "Ad2") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nonpermissive") (:form . "nonpermissive")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1050.9.2) (:span 38 43)) ((:id . :x1050.9.3) (:span 9 22)))\n (:ncues ((:id . :x1050.9.1) (:span 109 111)))\n (:hscopes ((:id . :x1050.9.2) (:span 23 149))\n  ((:id . :x1050.9.3) (:span 9 149)))\n (:nscopes ((:id . :x1050.9.1) (:span 109 149)))\n (:identifiers (:sid . :s1050.9) (:did . :|9201242|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009824@unknown@formal@none@1@S@Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta-amyloid") (:form . "beta-amyloid") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 82) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1051.1) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009825@unknown@formal@none@1@S@An increasing body of evidence suggests that amyloid-beta (A beta) peptides and microglia are crucially involved in the pathogenesis of Alzheimer's disease.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "amyloid-beta") (:form . "amyloid-beta") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "RB") (:stem . "crucially") (:form . "crucially") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 132)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Alzheimer") (:form . "Alzheimer") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1051.2.1) (:span 31 39)))\n (:hscopes ((:id . :x1051.2.1) (:span 31 155)))\n (:identifiers (:sid . :s1051.2) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009826@unknown@formal@none@1@S@In an effort to further elucidate the biological effects of A beta towards microglia, we investigated the ability of A beta peptides to activate nuclear factor (NF)-kappa B in the N9 murine microglial cell line.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "effort") (:form . "effort") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 101)\n  (:start . 89) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 170)\n  (:start . 161) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "N9") (:form . "N9") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 189)\n  (:start . 183) (:id . 75))\n ((:tag . "JJ") (:stem . "microglial") (:form . "microglial") (:end . 200)\n  (:start . 190) (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 205) (:start . 201)\n  (:id . 77))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 210) (:start . 206)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1051.3) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009827@unknown@formal@none@1@S@Co-stimulation of microglia with suboptimal concentrations of A beta(25-35) and 100 U/ml IFN gamma resulted in the detection of a specific NF-kappa B DNA-binding activity in nuclear extracts, as determined in gel mobility shift assays.@(((:tag . "NN") (:stem . "co-stimulation") (:form . "Co-stimulation")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "suboptimal") (:form . "suboptimal") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 58) (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "beta(25-35)") (:form . "beta(25-35)") (:end . 75)\n  (:start . 64) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 161)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 170)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 190)\n  (:start . 182) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 205)\n  (:start . 195) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 221)\n  (:start . 213) (:id . 75))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 227)\n  (:start . 222) (:id . 76))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 234)\n  (:start . 228) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1051.4) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009828@unknown@formal@none@1@S@This response required at least 120 min to be evident and supershift experiments revealed that the NF-kappa B complex contains both RelA and p50.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1051.5) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009830@unknown@formal@none@1@S@Higher concentrations of A beta(25-35) were effective by themselves in inducing NF-kappa B activation, both in the N9 microglial cell line and in rat primary microglia, as well as in human monocytes.@(((:tag . "JJR") (:stem . "high") (:form . "Higher") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 21) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta(25-35)") (:form . "beta(25-35)") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "themselves") (:form . "themselves") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "N9") (:form . "N9") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "microglial") (:form . "microglial") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 188)\n  (:start . 183) (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 198)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1051.7) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009831@unknown@formal@none@1@S@For purposes of comparison, microglia were also stimulated with bacterial LPS, a known NF-kappa B inducer.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "purpose") (:form . "purposes") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1051.8) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009832@unknown@formal@none@1@S@As expected, LPS strongly induced the formation of two NF-kappa B DNA-binding activities, one of which was identified as RelA/p50.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RelA/p50") (:form . "RelA/p50") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1051.9) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009833@unknown@formal@none@1@S@The LPS response was also more rapid, as it was already evident by 40 min and remained sustained for up to 3 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 52))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 55)\n  (:start . 48) (:id . 53))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 63)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 86)\n  (:start . 78) (:id . 59))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 96)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "IN") (:stem . "up") (:form . "up") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 108) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 110) (:start . 109)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1051.10) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009834@unknown@formal@none@1@S@Collectively, these findings indicate that NF-kappa B activation might constitute one of the mechanisms underlying the inducible expression of kappa B-dependent genes in microglia stimulated by A beta peptides and IFN gamma, or by LPS.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "VB") (:stem . "constitute") (:form . "constitute") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 148)\n  (:start . 143) (:id . 62))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 160)\n  (:start . 149) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 166)\n  (:start . 161) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "microglia") (:form . "microglia") (:end . 179)\n  (:start . 170) (:id . 66))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 190)\n  (:start . 180) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 193) (:start . 191)\n  (:id . 68))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 195) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 200) (:start . 196)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "peptide") (:form . "peptides") (:end . 209)\n  (:start . 201) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 223)\n  (:start . 218) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 224) (:start . 223)\n  (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 230) (:start . 228)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 234) (:start . 231)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1051.11.1) (:span 225 227))\n  ((:id . :x1051.11.2) (:span 65 70)) ((:id . :x1051.11.3) (:span 29 42)))\n (:hscopes ((:id . :x1051.11.1) (:span 191 234))\n  ((:id . :x1051.11.2) (:span 65 234)) ((:id . :x1051.11.3) (:span 29 234)))\n (:identifiers (:sid . :s1051.11) (:did . :|9209268|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009835@unknown@formal@none@1@S@AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-I promoter central 21 bp repeat.@(((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "astrocyte") (:form . "astrocytes") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 120)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1052.1) (:did . :|9209284|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009836@unknown@formal@none@1@S@Characterization of the cellular transcription factors interacting with the human T cell lymphotropic virus type I (HTLV-I) long terminal repeat (LTR) is essential to dissecting the mechanisms involved in viral transcription that may be pertinent to the oncogenic and neuropathogenic processes associated with HTLV-I infection in both the immune and nervous systems.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . 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"may") (:form . "may") (:end . 233) (:start . 230)\n  (:id . 78))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 236) (:start . 234)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "pertinent") (:form . "pertinent") (:end . 246)\n  (:start . 237) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 249) (:start . 247)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 253) (:start . 250)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 263)\n  (:start . 254) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 267) (:start . 264)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "neuropathogenic") (:form . "neuropathogenic")\n  (:end . 283) (:start . 268) (:id . 85))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 293)\n  (:start . 284) (:id . 86))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 304)\n  (:start . 294) (:id . 87))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 309) (:start . 305)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 316)\n  (:start . 310) (:id . 89))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 326)\n  (:start . 317) (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 329) (:start . 327)\n  (:id . 91))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 334) (:start . 330)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 338) (:start . 335)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 345)\n  (:start . 339) (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 349) (:start . 346)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 357)\n  (:start . 350) (:id . 96))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 365)\n  (:start . 358) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 366) (:start . 365)\n  (:id . 98)))@@@1@57@((:hcues ((:id . :x1052.2.1) (:span 230 233)))\n (:hscopes ((:id . :x1052.2.1) (:span 230 365)))\n (:identifiers (:sid . :s1052.2) (:did . :|9209284|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009837@unknown@formal@none@1@S@Electrophoretic mobility shift (EMS) analyses utilizing oligonucleotides homologous to each of the 21 bp repeat elements reacted with nuclear extracts derived from cell lines of lymphocytic, monocytic, neuronal, and glial cell origin have demonstrated differential binding of cellular factors to the three 21 bp repeats (1-4).@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EMS") (:form . "EMS") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "analysis") (:form . 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"repeat") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "VBD") (:stem . "react") (:form . "reacted") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 174)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . 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"origin") (:end . 233)\n  (:start . 227) (:id . 78))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 238) (:start . 234)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 251)\n  (:start . 239) (:id . 80))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 264)\n  (:start . 252) (:id . 81))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 272)\n  (:start . 265) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 275) (:start . 273)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 284)\n  (:start . 276) (:id . 84))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 292)\n  (:start . 285) (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 295) (:start . 293)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 299) (:start . 296)\n  (:id . 87))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 305)\n  (:start . 300) (:id . 88))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 308) (:start . 306)\n  (:id . 89))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 311) (:start . 309)\n  (:id . 90))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 319)\n  (:start . 312) (:id . 91))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 321) (:start . 320)\n  (:id . 92))\n ((:tag . "CD") (:stem . "1-4") (:form . "1-4") (:end . 324) (:start . 321)\n  (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 325) (:start . 324)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 326) (:start . 325)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s1052.3) (:did . :|9209284|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009838@unknown@formal@none@1@S@ATF/CREB and Sp family members interacted with the 21 bp repeats to form DNA-protein complexes common to all cell types examined.@(((:tag . "NNP") (:stem . "ATF/CREB") (:form . "ATF/CREB") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Sp") (:form . "Sp") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1052.4) (:did . :|9209284|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009840@unknown@formal@none@1@S@Based on nucleotide sequence requirements and immunoreactivity, we demonstrate that this DNA-protein complex is comprised of the AP-1 components, Fos and Jun.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunoreactivity") (:form . "immunoreactivity")\n  (:end . 62) (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "comprise") (:form . "comprised") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Fos") (:form . "Fos") (:end . 149) (:start . 146)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jun") (:form . "Jun") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1052.6) (:did . :|9209284|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009841@unknown@formal@none@1@S@Of the GATA-binding proteins, only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 19)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata-4") (:form . "GATA-4") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "producing") (:form . "producing") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 152)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 161)\n  (:start . 153) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1053.1) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009842@unknown@formal@none@1@S@Interleukin-5 (IL-5) is produced by T lymphocytes and known to support B cell growth and eosinophilic differentiation of the progenitor cells.@(((:tag . "NNP") (:stem . "Interleukin-5") (:form . "Interleukin-5")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 49)\n  (:start . 38) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 101)\n  (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 117) (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1053.2) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009843@unknown@formal@none@1@S@Using ATL-16T cells which express IL-5 mRNA, we have identified a region, within the human IL-5 gene promoter, that regulates IL-5 gene transcription.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "atl-16t") (:form . "ATL-16T") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 109)\n  (:start . 101) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 125)\n  (:start . 116) (:id . 64))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1053.3) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009844@unknown@formal@none@1@S@This cis-acting sequence contains the core binding motif, (A/T)GATA(A/G), for GATA-binding family proteins and thus suggests the involvement of these family members.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "A/T)GATA(A/G)") (:form . "A/T)GATA(A/G)")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 90)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 156)\n  (:start . 150) (:id . 65))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1053.4.1) (:span 116 124)))\n (:hscopes ((:id . :x1053.4.1) (:span 116 164)))\n (:identifiers (:sid . :s1053.4) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009845@unknown@formal@none@1@S@In this report, we describe the cloning of human GATA-4 (hGATA-4) and show that hGATA-4 selectively interacts with the -70 GATA site within the IL-5 proximal promoter region.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gata-4") (:form . "GATA-4") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hgata-4") (:form . "hGATA-4") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 74) (:start . 70)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hgata-4") (:form . "hGATA-4") (:end . 87)\n  (:start . 80) (:id . 59))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 99)\n  (:start . 88) (:id . 60))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-70") (:form . "-70") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 132) (:start . 128)\n  (:id . 66))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 139)\n  (:start . 133) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 148) (:start . 144)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 157)\n  (:start . 149) (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 166)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 173)\n  (:start . 167) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1053.5) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009846@unknown@formal@none@1@S@By promoter deletion and mutation analyses, we established this region as a positive regulatory element.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1053.6) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009847@unknown@formal@none@1@S@Cotransfection experiments revealed that both hGATA-4 and PMA/A23187 stimulation are necessary for the IL-5 promoter activation.@(((:tag . "NN") (:stem . "cotransfection") (:form . "Cotransfection")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 26)\n  (:start . 15) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 35)\n  (:start . 27) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 45) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hgata-4") (:form . "hGATA-4") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pma/a23187") (:form . "PMA/A23187") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 80)\n  (:start . 69) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 116)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1053.7) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009848@unknown@formal@none@1@S@The requirement of another regulatory element called CLE0, which lies downstream of the -70 GATA site, was also demonstrated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 52) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "-70") (:form . "-70") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 124)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1053.8) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009850@unknown@formal@none@1@S@However, using ATL-16T nuclear extract, we demonstrated that GATA-4 is the only GATA-binding protein that forms specific DNA-protein complex with the -70 GATA site.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ATL-16T") (:form . "ATL-16T") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 55)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gata-4") (:form . "GATA-4") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-70") (:form . "-70") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1053.10) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009851@unknown@formal@none@1@S@The electrophoretic mobility shift assay with extracts of COS cells expressing GATA-binding proteins showed that GATA-4 has the highest binding affinity to the -70 GATA site among the three GATA-binding proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "COS") (:form . "COS") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 91)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gata-4") (:form . "GATA-4") (:end . 119)\n  (:start . 113) (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 152)\n  (:start . 144) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-70") (:form . "-70") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 189)\n  (:start . 184) (:id . 70))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 202)\n  (:start . 190) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 211)\n  (:start . 203) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1053.11) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009852@unknown@formal@none@1@S@When the transactivation ability was compared among the three, GATA-4 showed the highest activity.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gata-4") (:form . "GATA-4") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 76) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1053.12) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009853@unknown@formal@none@1@S@These results demonstrate the selective role of GATA-4 in the transcriptional regulation of the IL-5 gene in a circumstance where multiple members of the GATA-binding proteins are expressed.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gata-4") (:form . "GATA-4") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 77) (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "circumstance") (:form . "circumstance") (:end . 123)\n  (:start . 111) (:id . 60))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "gata-binding") (:form . "GATA-binding") (:end . 166)\n  (:start . 154) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 189)\n  (:start . 180) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1053.13) (:did . :|9209438|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009854@unknown@formal@none@1@S@Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells [see comments]@(((:tag . "JJ") (:stem . "inducible") (:form . "Inducible") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 40) (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 55)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 67)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1054.1) (:did . :|9211847|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009855@unknown@formal@none@1@S@BOB.1/OBF.1 is a transcriptional coactivator that is constitutively expressed in B cells and interacts with the Oct1 and Oct2 transcription factors.@(((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 67) (:start . 53) (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "oct1") (:form . "Oct1") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oct2") (:form . "Oct2") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1054.2) (:did . :|9211847|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009856@unknown@formal@none@1@S@Upon activation of Jurkat T cells and primary murine thymocytes with phorbol esters and ionomycin, BOB.1/OBF.1 expression and transactivation function were induced.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ionomycin") (:form . "ionomycin") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bob.1/obf.1") (:form . "BOB.1/OBF.1") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 141) (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 150)\n  (:start . 142) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 163)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1054.3) (:did . :|9211847|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009857@unknown@formal@none@1@S@BOB.1/OBF.1 was phosphorylated at Ser184 both in vivo and in vitro, and this modification was required for inducible activation.@(((:tag . "NNP") (:stem . "BOB.1/OBF.1") (:form . "BOB.1/OBF.1") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 30) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ser184") (:form . "Ser184") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 89)\n  (:start . 77) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1054.4) (:did . :|9211847|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009858@unknown@formal@none@1@S@Mutation of Ser184 also diminished transactivation function in B cells, suggesting that the activating phosphorylation that is inducible in T cells is constitutively present in B cells.@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ser184") (:form . "Ser184") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 118) (:start . 103) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 165) (:start . 151) (:id . 65))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 173)\n  (:start . 166) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 178) (:start . 177)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 184)\n  (:start . 179) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1054.5.1) (:span 72 82)))\n (:hscopes ((:id . :x1054.5.1) (:span 72 184)))\n (:identifiers (:sid . :s1054.5) (:did . :|9211847|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009860@unknown@formal@none@1@S@Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.@(((:tag . "NNP") (:stem . "Lipopolysaccharide") (:form . "Lipopolysaccharide")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 28)\n  (:start . 19) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 63)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1055.1) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009861@unknown@formal@none@1@S@Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1055.2) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009862@unknown@formal@none@1@S@Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.@(((:tag . "NN") (:stem . "biosynthesis") (:form . "Biosynthesis") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1055.3) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009863@unknown@formal@none@1@S@This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 96) (:start . 78) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 166)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 174)\n  (:start . 167) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1055.4) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009864@unknown@formal@none@1@S@Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "length") (:form . "lengths") (:end . 97)\n  (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 129)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 138)\n  (:start . 130) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 147)\n  (:start . 139) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 159)\n  (:start . 153) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 63))\n ((:tag . "CD") (:stem . "-182") (:form . "-182") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "CD") (:stem . "-37") (:form . "-37") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 183)\n  (:start . 178) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 185) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 199) (:start . 195)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 208)\n  (:start . 200) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 220)\n  (:start . 213) (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 234) (:start . 221) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 251)\n  (:start . 242) (:id . 81))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 256) (:start . 252)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 259) (:start . 257)\n  (:id . 83))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 268)\n  (:start . 260) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 271) (:start . 269)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 275) (:start . 272)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1055.5) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009865@unknown@formal@none@1@S@Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "CD") (:stem . "-182") (:form . "-182") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-162") (:form . "-162") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 65)\n  (:start . 56) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 80)\n  (:start . 69) (:id . 57))\n ((:tag . "NN") (:stem . "sp1/egr-1") (:form . "Sp1/Egr-1") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 107)\n  (:start . 101) (:id . 62))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-119") (:form . "-119") (:end . 116) (:start . 112)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-88") (:form . "-88") (:end . 123) (:start . 120)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 134)\n  (:start . 125) (:id . 69))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 138) (:start . 135)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 152)\n  (:start . 143) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 164)\n  (:start . 154) (:id . 74))\n ((:tag . "NN") (:stem . "kappab3") (:form . "kappaB3") (:end . 172)\n  (:start . 165) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 179)\n  (:start . 174) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1055.6) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009866@unknown@formal@none@1@S@In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cre-binding") (:form . "CRE-binding") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 59) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1055.7) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009867@unknown@formal@none@1@S@LPS stimulation increased the binding of c-Jun-containing complexes.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "c-jun-containing") (:form . "c-Jun-containing")\n  (:end . 57) (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1055.8) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009868@unknown@formal@none@1@S@In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappab3") (:form . "kappaB3") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 150)\n  (:start . 143) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 164)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1055.9) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009870@unknown@formal@none@1@S@Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "spacing") (:form . "spacing") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappab3") (:form . "kappaB3") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 146)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 160)\n  (:start . 155) (:id . 64))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 170)\n  (:start . 161) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 182)\n  (:start . 175) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1055.11.1) (:span 110 120)))\n (:hscopes ((:id . :x1055.11.1) (:span 110 182)))\n (:identifiers (:sid . :s1055.11) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009871@unknown@formal@none@1@S@These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "concerted") (:form . "concerted") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 114) (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 161)\n  (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 170)\n  (:start . 162) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1055.12.1) (:span 14 27)))\n (:hscopes ((:id . :x1055.12.1) (:span 14 170)))\n (:identifiers (:sid . :s1055.12) (:did . :|9211933|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009872@unknown@formal@none@1@S@Role of the X2 box in activated transcription from the DRA promoter in B cells.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1056.1) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009873@unknown@formal@none@1@S@We investigated the function of the evolutionary conserved X2 box in the promoter of the HLA-DRA gene from the human major histocompatibility complex (MHC) in resting and activated B cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 141) (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 180)\n  (:start . 171) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 182) (:start . 181)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 188)\n  (:start . 183) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1056.2) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009874@unknown@formal@none@1@S@NF-X2, which contains members of the AP-1/ATF/CREB families of transcription factors, interacts with the X2 box (5'-TGCGTCA-3') from positions -97 to -91 in the DRA promoter.@(((:tag . "NNP") (:stem . "NF-X2") (:form . "NF-X2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP-1/ATF/CREB") (:form . "AP-1/ATF/CREB")\n  (:end . 50) (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "5'-TGCGTCA-3") (:form . "5'-TGCGTCA-3")\n  (:end . 125) (:start . 113) (:id . 61))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 142)\n  (:start . 133) (:id . 65))\n ((:tag . "CD") (:stem . "-97") (:form . "-97") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "CD") (:stem . "-91") (:form . "-91") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 173)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1056.3) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009875@unknown@formal@none@1@S@In resting Raji cells, little to no binding to the X2 box was observed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 10) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 70)\n  (:start . 62) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1056.4.1) (:span 33 35)))\n (:nscopes ((:id . :x1056.4.1) (:span 33 70)))\n (:identifiers (:sid . :s1056.4) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009876@unknown@formal@none@1@S@In sharp contrast, in B cells treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), strong interactions between the X2 box and NF-X2 containing c-Fos were observed.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "sharp") (:form . "sharp") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 37)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol-13-acetate")\n  (:form . "12-O-tetradecanoylphorbol-13-acetate") (:end . 97) (:start . 61)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 124)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nf-x2") (:form . "NF-X2") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 164)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1056.5) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009877@unknown@formal@none@1@S@As determined by transient expression and RNA analyses, the activation of protein kinase C (PKC) also increased rates of transcription from the wild-type DRA promoter but not from a DRA promoter bearing clustered point mutations in the X2 box.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 111)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 134) (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 153)\n  (:start . 144) (:id . 67))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 185) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 194)\n  (:start . 186) (:id . 75))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 202)\n  (:start . 195) (:id . 76))\n ((:tag . "VBN") (:stem . "cluster") (:form . "clustered") (:end . 212)\n  (:start . 203) (:id . 77))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 218)\n  (:start . 213) (:id . 78))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 228)\n  (:start . 219) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 231) (:start . 229)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 81))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 238) (:start . 236)\n  (:id . 82))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 242) (:start . 239)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x1056.6.1) (:span 171 174)))\n (:nscopes ((:id . :x1056.6.1) (:span 171 242)))\n (:identifiers (:sid . :s1056.6) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009878@unknown@formal@none@1@S@Since the co-expression with a dominant negative c-Fos abolished the responsiveness to TPA, we conclude that activated transcription of the DRA gene depends on interactions between the X2 box and NF-X2, which contains c-Fos.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "co-expression") (:form . "co-expression")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 83) (:start . 69) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "DRA") (:form . "DRA") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 172)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 180)\n  (:start . 173) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NN") (:stem . "x2") (:form . "X2") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "nf-x2") (:form . "NF-X2") (:end . 201)\n  (:start . 196) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 208)\n  (:start . 203) (:id . 75))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 217)\n  (:start . 209) (:id . 76))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 223)\n  (:start . 218) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1056.7) (:did . :|9218534|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009880@unknown@formal@none@1@S@The control of cell survival and cell death is of central importance in tissues with high cell turnover such as the lymphoid system.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 131)\n  (:start . 125) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1057.2) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009881@unknown@formal@none@1@S@We have examined the effect of cytokines on IL-2 deprivation-induced apoptosis of human antigen-specific T helper clones with different cytokine production profiles.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "deprivation-induced")\n  (:form . "deprivation-induced") (:end . 68) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "antigen-specific") (:form . "antigen-specific")\n  (:end . 104) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 120)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 155)\n  (:start . 145) (:id . 62))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1057.3) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009882@unknown@formal@none@1@S@We found that IL-2, interferon-alpha (IFN-alpha), and IFN-beta inhibited IL-2 deprivation apoptosis in Th0, Th1, and Th2 clones.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interferon-alpha") (:form . "interferon-alpha")\n  (:end . 36) (:start . 20) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IFN-beta") (:form . "IFN-beta") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 72)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Th0") (:form . "Th0") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Th1") (:form . "Th1") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 127)\n  (:start . 121) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1057.4) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009883@unknown@formal@none@1@S@We also found that IL-2 protects T cell clones from IL-2 deprivation apoptosis accompanying active proliferation and enhanced expression of P53, Rb and Bcl-xL proteins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "VBG") (:stem . "accompany") (:form . "accompanying") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "P53") (:form . "P53") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Rb") (:form . "Rb") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Bcl-xL") (:form . "Bcl-xL") (:end . 158)\n  (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1057.5) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009884@unknown@formal@none@1@S@In contrast, IFN-alpha/beta rescued T cell clones from apoptosis without active proliferation, and expression of apoptosis-associated proteins tested so far was unaffected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IFN-alpha/beta") (:form . "IFN-alpha/beta")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 93) (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "apoptosis-associated")\n  (:form . "apoptosis-associated") (:end . 133) (:start . 113) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 142)\n  (:start . 134) (:id . 60))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 149)\n  (:start . 143) (:id . 61))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 156) (:start . 153)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 171)\n  (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1057.6.1) (:span 65 72)))\n (:nscopes ((:id . :x1057.6.1) (:span 65 93)))\n (:identifiers (:sid . :s1057.6) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009885@unknown@formal@none@1@S@This may be due to the fact that T cells treated with IL-2 contained those located in S + G2/M phases of the cell cycle, whereas the vast majority of T cells treated with IFN-alpha/beta were located in G0/G1 phase.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 48)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 68)\n  (:start . 59) (:id . 55))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "G2/M") (:form . "G2/M") (:end . 94) (:start . 90)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 101)\n  (:start . 95) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 119)\n  (:start . 114) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 67))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 128)\n  (:start . 121) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "vast") (:form . "vast") (:end . 137) (:start . 133)\n  (:id . 70))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 146)\n  (:start . 138) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 151) (:start . 150)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 74))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 165)\n  (:start . 158) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IFN-alpha/beta") (:form . "IFN-alpha/beta")\n  (:end . 185) (:start . 171) (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 190) (:start . 186)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 198)\n  (:start . 191) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 80))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 207)\n  (:start . 202) (:id . 81))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 213)\n  (:start . 208) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1057.7.1) (:span 5 8)))\n (:hscopes ((:id . :x1057.7.1) (:span 5 213)))\n (:identifiers (:sid . :s1057.7) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009886@unknown@formal@none@1@S@IFN-alpha/beta specifically induced tyrosine phosphorylation and translocation into nucleus of signal transducers and activators of transcription (STAT) 2 protein in the T cell clones.@(((:tag . "NNP") (:stem . "IFN-alpha/beta") (:form . "IFN-alpha/beta")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 27)\n  (:start . 15) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 35)\n  (:start . 28) (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 44)\n  (:start . 36) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 60) (:start . 45) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 47))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 78) (:start . 65) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 83) (:start . 79)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 91)\n  (:start . 84) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 101)\n  (:start . 95) (:id . 52))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 113)\n  (:start . 102) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 128)\n  (:start . 118) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 145) (:start . 132) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 151) (:start . 147)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 60))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 154) (:start . 153)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 171) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 183)\n  (:start . 177) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1057.8) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009887@unknown@formal@none@1@S@In addition, over-expression of STAT2 by transfection of the cDNA prevented apoptosis of the T cell clones.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "over-expression") (:form . "over-expression")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stat2") (:form . "STAT2") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 53)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1057.9) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009888@unknown@formal@none@1@S@Our present study shows that IFN-alpha and -beta mediate anti-apoptotic effect through other pathways than that of IL-2 in growth factor deprivation apoptosis.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 71) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 136)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1057.10) (:did . :|9218843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009890@unknown@formal@none@1@S@It is known that the expression levels of intercellular adhesion molecule-1 (ICAM-1) in adult T cell leukemia(ATL) cells are high, whereas those in T-lymphoid cells are not.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "leukemia(ATL)") (:form . "leukemia(ATL)")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t-lymphoid") (:form . "T-lymphoid") (:end . 158)\n  (:start . 148) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1058.2.1) (:span 169 172)))\n (:nscopes ((:id . :x1058.2.1) (:span 169 172)))\n (:identifiers (:sid . :s1058.2) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009891@unknown@formal@none@1@S@In order to investigate the factors that influence the induction of ICAM-1 molecules, Northern blot analysis to measure the expression level of ICAM-1 mRNAs and Southern blot hybridization to analyze the integration of human T-cell-leukemia virus type 1 (HTLV-1) provirus were done.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "influence") (:form . "influence") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "southern") (:form . "Southern") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 188) (:start . 175) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 199)\n  (:start . 192) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 215)\n  (:start . 204) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 224)\n  (:start . 219) (:id . 76))\n ((:tag . "JJ") (:stem . "t-cell-leukemia") (:form . "T-cell-leukemia")\n  (:end . 240) (:start . 225) (:id . 77))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 246)\n  (:start . 241) (:id . 78))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 251) (:start . 247)\n  (:id . 79))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 253) (:start . 252)\n  (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 255) (:start . 254)\n  (:id . 81))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 261)\n  (:start . 255) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 262) (:start . 261)\n  (:id . 83))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 271)\n  (:start . 263) (:id . 84))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 276) (:start . 272)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 281) (:start . 277)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1058.3) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009892@unknown@formal@none@1@S@The levels of ICAM-1 mRNA expression of ATL cells were generally higher than those of T-lymphoid cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 71) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-lymphoid") (:form . "T-lymphoid") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1058.4) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009893@unknown@formal@none@1@S@However, ILT-mat cells and ATL16T(-) cells, although they were ATL cells, showed rather low surface ICAM-1 expression and ICAM-1 mRNA expression.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "ILT-mat") (:form . "ILT-mat") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ATL16T(-)") (:form . "ATL16T(-)") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "atl") (:form . "ATL") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 80) (:start . 74)\n  (:id . 56))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1058.5) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009894@unknown@formal@none@1@S@Southern blot hybridization showed that only two and four bands were found in ILT-mat and ATL16T(-) cells, respectively, whereas > 10 bands were detected in other ATL cells.@(((:tag . "NNP") (:stem . "Southern") (:form . "Southern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 34) (:start . 28)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "band") (:form . "bands") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ILT-mat") (:form . "ILT-mat") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ATL16T(-)") (:form . "ATL16T(-)") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "JJR") (:stem . ">") (:form . ">") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "band") (:form . "bands") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 153)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NNP") (:stem . "ATL") (:form . "ATL") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1058.6) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009895@unknown@formal@none@1@S@These results suggest that monoclonal integration of HTLV-1 provirus to the genome of T cell, especially the number of integration sites, is one of the factors for induction of ICAM-1 molecules.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 173)\n  (:start . 164) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 183)\n  (:start . 177) (:id . 73))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1058.7.1) (:span 14 21)))\n (:hscopes ((:id . :x1058.7.1) (:span 14 193)))\n (:identifiers (:sid . :s1058.7) (:did . :|9219058|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009896@unknown@formal@none@1@S@Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 75) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 108)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 113) (:start . 109)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 127)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "NN") (:stem . "infectivity") (:form . "infectivity") (:end . 149)\n  (:start . 138) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1059.1) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009897@unknown@formal@none@1@S@When transcriptionally active, the human immunodeficiency virus (HIV) promoter contains a nucleosome-free region encompassing both the promoter/enhancer region and a large region (255 nucleotides [nt]) downstream of the transcription start site.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 22) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 29)\n  (:start . 23) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 57) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nucleosome-free") (:form . "nucleosome-free")\n  (:end . 105) (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 125)\n  (:start . 113) (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter/enhancer") (:form . "promoter/enhancer")\n  (:end . 152) (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 159)\n  (:start . 153) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 67))\n ((:tag . "CD") (:stem . "255") (:form . "255") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 195)\n  (:start . 184) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 197) (:start . 196)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nt") (:form . "nt") (:end . 199) (:start . 197)\n  (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 200) (:start . 199)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 201) (:start . 200)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 212)\n  (:start . 202) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 233) (:start . 220) (:id . 77))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 239)\n  (:start . 234) (:id . 78))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 244) (:start . 240)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1059.2) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009898@unknown@formal@none@1@S@We have previously identified new binding sites for transcription factors downstream of the transcription start site (nt 465 to 720): three AP-1 sites (I, II, and III), an AP3-like motif (AP3-L), a downstream binding factor (DBF) site, and juxtaposed Sp1 sites.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 111)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "nt") (:form . 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"AP3-L") (:form . "AP3-L") (:end . 193)\n  (:start . 188) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 83))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 208)\n  (:start . 198) (:id . 85))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 216)\n  (:start . 209) (:id . 86))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 223)\n  (:start . 217) (:id . 87))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 225) (:start . 224)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "DBF") (:form . "DBF") (:end . 228) (:start . 225)\n  (:id . 89))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 229) (:start . 228)\n  (:id . 90))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 234) (:start . 230)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 235) (:start . 234)\n  (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 93))\n ((:tag . "VBN") (:stem . "juxtapose") (:form . "juxtaposed") (:end . 250)\n  (:start . 240) (:id . 94))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 254) (:start . 251)\n  (:id . 95))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 260)\n  (:start . 255) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s1059.3) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009900@unknown@formal@none@1@S@Mutations that abolish the binding of each factor to its cognate site are introduced in an infectious HIV-1 molecular clone to study their effect on HIV-1 transcription and replication.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "abolish") (:form . "abolish") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 184)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1059.5) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009901@unknown@formal@none@1@S@Individual mutation of the DBF or AP3-L site as well as the double mutation AP-1(III)/AP3-L did not affect HIV-1 replication compared to that of the wild-type virus.@(((:tag . "JJ") (:stem . "individual") (:form . "Individual") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DBF") (:form . "DBF") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "AP3-L") (:form . "AP3-L") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "NNP") (:stem . "AP-1(III)/AP3-L") (:form . "AP-1(III)/AP3-L")\n  (:end . 91) (:start . 76) (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 164)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1059.6.1) (:span 96 99)))\n (:nscopes ((:id . :x1059.6.1) (:span 96 164)))\n (:identifiers (:sid . :s1059.6) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009902@unknown@formal@none@1@S@In contrast, proviruses carrying mutations in the Sp1 sites were totally defective in terms of replication.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "provirus") (:form . "proviruses") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 106)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1059.7) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009903@unknown@formal@none@1@S@Virus production occurred with slightly delayed kinetics for viruses containing combined mutations in the AP-1(III), AP3-L, and DBF sites and in the AP3-L and DBF-sites, whereas viruses mutated in the AP-1(I,II,III) and AP3-L sites and in the AP-1(I,II,III), AP3-L, and DBF sites exhibited a severely defective replicative phenotype.@(((:tag . "NN") (:stem . "virus") (:form . "Virus") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "kinetic") (:form . 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",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 185)\n  (:start . 178) (:id . 71))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 193)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "AP-1(I,II,III)") (:form . "AP-1(I,II,III)")\n  (:end . 215) (:start . 201) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ap3-l") (:form . "AP3-L") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 231)\n  (:start . 226) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . 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"exhibited") (:end . 289)\n  (:start . 280) (:id . 89))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 291) (:start . 290)\n  (:id . 90))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 300)\n  (:start . 292) (:id . 91))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 310)\n  (:start . 301) (:id . 92))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 322)\n  (:start . 311) (:id . 93))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 332)\n  (:start . 323) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 333) (:start . 332)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s1059.8) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009904@unknown@formal@none@1@S@No RNA-packaging defect could be measured for any of the mutant viruses as determined by quantification of their HIV genomic RNA.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "rna-packaging") (:form . "RNA-packaging")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "quantification") (:form . "quantification")\n  (:end . 103) (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1059.9.1) (:span 0 2)))\n (:nscopes ((:id . :x1059.9.1) (:span 0 128)))\n (:identifiers (:sid . :s1059.9) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009905@unknown@formal@none@1@S@Measurement of the transcriptional activity of the HIV-1 promoter after transient transfection of the HIV-1 provirus DNA or of long terminal repeat-luciferase constructs showed a positive correlation between the transcriptional and the replication defects for most mutants.@(((:tag . "NNP") (:stem . "Measurement") (:form . "Measurement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 34) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 94)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "repeat-luciferase") (:form . "repeat-luciferase")\n  (:end . 158) (:start . 141) (:id . 63))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 176)\n  (:start . 170) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 178) (:start . 177)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 187)\n  (:start . 179) (:id . 67))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 199)\n  (:start . 188) (:id . 68))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 207)\n  (:start . 200) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 227) (:start . 212) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 73))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 247)\n  (:start . 236) (:id . 74))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 255)\n  (:start . 248) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 259) (:start . 256)\n  (:id . 76))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 264) (:start . 260)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 272)\n  (:start . 265) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1059.10) (:did . :|9223506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009906@unknown@formal@none@1@S@The role of nuclear factor-kappa B in cytokine gene regulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 32)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1060.1) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009907@unknown@formal@none@1@S@Transcription factors are DNA-binding proteins that regulate gene expression.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1060.2) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009908@unknown@formal@none@1@S@Nuclear factor-kappa B (NF-kappa B) is a critical transcription factor for maximal expression of many cytokines that are involved in the pathogenesis of inflammatory diseases, such as adult respiratory distress syndrome (ARDS) and sepsis syndrome.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 149)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 165)\n  (:start . 153) (:id . 67))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 201)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "distress") (:form . "distress") (:end . 210)\n  (:start . 202) (:id . 74))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 219)\n  (:start . 211) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 221) (:start . 220)\n  (:id . 76))\n ((:tag . "NNPS") (:stem . "ARDS") (:form . "ARDS") (:end . 225)\n  (:start . 221) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 226) (:start . 225)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 79))\n ((:tag . "NN") (:stem . "sepsis") (:form . "sepsis") (:end . 237)\n  (:start . 231) (:id . 80))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 246)\n  (:start . 238) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1060.3) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009910@unknown@formal@none@1@S@NF-kappa B activation involves signaled phosphorylation, ubiquitination, and proteolysis of I kappa B.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "signal") (:form . "signaled") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 55) (:start . 40) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 71) (:start . 57) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 88)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1060.5) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009911@unknown@formal@none@1@S@Liberated NF-kappa B migrates to the nucleus, where it binds to specific promoter sites and activates gene transcription.@(((:tag . "VBN") (:stem . "liberate") (:form . "Liberated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "migrate") (:form . "migrates") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1060.6) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009912@unknown@formal@none@1@S@The activation of NF-kappa B initiates both extracellular and intracellular regulatory events that result in autoregulation of the inflammatory cascade through modulation of NF-kappa B activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 75) (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "autoregulation") (:form . "autoregulation")\n  (:end . 123) (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 143)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 151)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 159)\n  (:start . 152) (:id . 62))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 170)\n  (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 184) (:start . 183)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 195)\n  (:start . 185) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1060.7) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009913@unknown@formal@none@1@S@Recently, activation of NF-kappa B has been linked to ARDS and has been shown to be a critical proximal step in the initiation of neutrophilic inflammation in animal models.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 50) (:start . 44)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "ARDS") (:form . "ARDS") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 94)\n  (:start . 86) (:id . 60))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 108) (:start . 104)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 126)\n  (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "neutrophilic") (:form . "neutrophilic") (:end . 142)\n  (:start . 130) (:id . 67))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 155)\n  (:start . 143) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 165)\n  (:start . 159) (:id . 70))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1060.8) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009914@unknown@formal@none@1@S@Activation of NF-kappa B can be inhibited in vivo by treatment with antioxidants, corticosteroids, and the induction of endotoxin tolerance.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 80)\n  (:start . 68) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "corticosteroid") (:form . "corticosteroids")\n  (:end . 97) (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1060.9) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009915@unknown@formal@none@1@S@Identification of more specific and efficacious inhibitors of NF-kappa B activation might prove beneficial for the treatment of cytokine-mediated inflammatory diseases.@(((:tag . "NN") (:stem . "identification") (:form . "Identification")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "efficacious") (:form . "efficacious") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cytokine-mediated") (:form . "cytokine-mediated")\n  (:end . 145) (:start . 128) (:id . 60))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 158)\n  (:start . 146) (:id . 61))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 167)\n  (:start . 159) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1060.10.1) (:span 84 89)))\n (:hscopes ((:id . :x1060.10.1) (:span 84 167)))\n (:identifiers (:sid . :s1060.10) (:did . :|9224203|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009916@unknown@formal@none@1@S@Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1061.1) (:did . :|9224625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009917@unknown@formal@none@1@S@The first product of ascorbate oxidation, the ascorbate free radical (AFR), acts in biological systems mainly as an oxidant, and through its role in the plasma membrane redox system exerts different effects on the cell.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "oxidation") (:form . "oxidation") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AFR") (:form . "AFR") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 94)\n  (:start . 84) (:id . 59))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "oxidant") (:form . "oxidant") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 136)\n  (:start . 129) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 140) (:start . 137)\n  (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 145) (:start . 141)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 71))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 159)\n  (:start . 153) (:id . 72))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 168)\n  (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 174)\n  (:start . 169) (:id . 74))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 181)\n  (:start . 175) (:id . 75))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 188)\n  (:start . 182) (:id . 76))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 198)\n  (:start . 189) (:id . 77))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 206)\n  (:start . 199) (:id . 78))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 209) (:start . 207)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 218) (:start . 214)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1061.2) (:did . :|9224625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009918@unknown@formal@none@1@S@We have investigated the role of ascorbate, AFR and dehydroascorbate (DHA) in the activation of the NF-kappaB transcription factor in Jurkat T-cells stimulated by tumour necrosis factor-alpha (TNF-alpha).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "AFR") (:form . "AFR") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dehydroascorbate") (:form . "dehydroascorbate")\n  (:end . 68) (:start . 52) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DHA") (:form . "DHA") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 123) (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 159)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tumour") (:form . "tumour") (:end . 169)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 191)\n  (:start . 179) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 202)\n  (:start . 193) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1061.3) (:did . :|9224625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009920@unknown@formal@none@1@S@The ability of ascorbate to enhance cytoplasmic inhibitory IkBalpha protein degradation correlates completely with its capacity to induce NF-kappaB binding to DNA and to potentiate NF-kappaB-mediated transactivation of the HIV-1 long terminal repeat promoter in TNF-alpha-stimulated Jurkat cells but not in cells stimulated with PMA plus ionomycin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . 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5009921@unknown@formal@none@1@S@AFR behaves like ascorbate, while DHA and ascorbate phosphate do not affect TNF-alpha-mediated NF-kappaB activation.@(((:tag . "NNP") (:stem . "AFR") (:form . "AFR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "behave") (:form . "behaves") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DHA") (:form . "DHA") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "phosphate") (:form . "phosphate") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "JJ") (:stem . "tnf-alpha-mediated") (:form . "TNF-alpha-mediated")\n  (:end . 94) (:start . 76) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1061.6.1) (:span 65 68)))\n (:nscopes ((:id . :x1061.6.1) (:span 65 115)))\n (:identifiers (:sid . :s1061.6) (:did . :|9224625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009922@unknown@formal@none@1@S@These results provide new evidence for a possible relationship between the activation of the electron-transport system at the plasma membrane by ascorbate or its free radical and redox-dependent gene transcription in T-cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "electron-transport") (:form . "electron-transport")\n  (:end . 111) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 118)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ascorbate") (:form . "ascorbate") (:end . 154)\n  (:start . 145) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "redox-dependent") (:form . "redox-dependent")\n  (:end . 194) (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 213) (:start . 200) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 224)\n  (:start . 217) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1061.7.1) (:span 41 49)))\n (:hscopes ((:id . :x1061.7.1) (:span 41 224)))\n (:identifiers (:sid . :s1061.7) (:did . :|9224625|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009923@unknown@formal@none@1@S@Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.@(((:tag . "JJ") (:stem . "pancreatic") (:form . "Pancreatic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "islet") (:form . "islet") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "polymorphic") (:form . "polymorphic") (:end . 51)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "hepatocyte") (:form . "hepatocyte") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 104)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "factor-3alpha") (:form . "factor-3alpha")\n  (:end . 118) (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 57))\n ((:tag . "NN") (:stem . "-3beta") (:form . "-3beta") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "-3gamma") (:form . "-3gamma") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "-4gamma") (:form . "-4gamma") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "CD") (:stem . "-6") (:form . "-6") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1062.1) (:did . :|9231664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009924@unknown@formal@none@1@S@The genes encoding the functionally related hepatocyte nuclear factors HNF-1alpha and HNF-4alpha play a critical role in normal pancreatic beta-cell function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "hepatocyte") (:form . "hepatocyte") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NNP") (:stem . "HNF-1alpha") (:form . "HNF-1alpha") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HNF-4alpha") (:form . "HNF-4alpha") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "beta-cell") (:form . "beta-cell") (:end . 148)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 157)\n  (:start . 149) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1062.2) (:did . :|9231664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009925@unknown@formal@none@1@S@Mutations in these liver-enriched transcription factors result in two forms of early-onset type 2 diabetes (maturity-onset diabetes of the young [MODY]), MODY3 and MODY1, which are characterized by impaired glucose-stimulated insulin secretion, early disease onset, and autosomal dominant inheritance.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "liver-enriched") (:form . "liver-enriched")\n  (:end . 33) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 55)\n  (:start . 48) (:id . 47))\n ((:tag . "VBP") (:stem . "result") (:form . 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5009926@unknown@formal@none@1@S@The transcriptional hierarchy of HNFs suggests that other proteins of the regulatory cascade might be responsible for other forms of MODY and/or late-onset type 2 diabetes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "hierarchy") (:form . "hierarchy") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HNF") (:form . "HNFs") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 113)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "MODY") (:form . "MODY") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "JJ") (:stem . "late-onset") (:form . "late-onset") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 160) (:start . 156)\n  (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "diabete") (:form . "diabetes") (:end . 171)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1062.4.1) (:span 93 98))\n  ((:id . :x1062.4.2) (:span 38 46)))\n (:hscopes ((:id . :x1062.4.1) (:span 93 171))\n  ((:id . :x1062.4.2) (:span 38 171)))\n (:identifiers (:sid . :s1062.4) (:did . :|9231664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009927@unknown@formal@none@1@S@In this study, we show that HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 are expressed in pancreatic beta-cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HNF-3alpha") (:form . "HNF-3alpha") (:end . 38)\n  (:start . 28) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "-3beta") (:form . "-3beta") (:end . 46)\n  (:start . 40) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "-3gamma") (:form . "-3gamma") (:end . 55)\n  (:start . 48) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "-4gamma") (:form . "-4gamma") (:end . 64)\n  (:start . 57) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-6") (:form . "-6") (:end . 72) (:start . 70)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 86)\n  (:start . 77) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pancreatic") (:form . "pancreatic") (:end . 100)\n  (:start . 90) (:id . 62))\n ((:tag . "NNS") (:stem . "beta-cell") (:form . "beta-cells") (:end . 111)\n  (:start . 101) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1062.5) (:did . :|9231664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009928@unknown@formal@none@1@S@We report the identification and characterization of simple tandem repeat DNA polymorphisms in the genes encoding HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 and the mapping of HNF-6 to chromosome bands 15q21.1-21.2 by fluorescence in situ hybridization.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 49) (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "polymorphism") (:form . "polymorphisms")\n  (:end . 91) (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NNP") (:stem . "HNF-3alpha") (:form . "HNF-3alpha") (:end . 124)\n  (:start . 114) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "-3beta") (:form . "-3beta") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "-3gamma") (:form . "-3gamma") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "-4gamma") (:form . "-4gamma") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "-6") (:form . "-6") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 174)\n  (:start . 167) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hnf-6") (:form . "HNF-6") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 73))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 197)\n  (:start . 187) (:id . 74))\n ((:tag . "NNS") (:stem . "band") (:form . "bands") (:end . 203)\n  (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "15q21.1-21.2") (:form . "15q21.1-21.2") (:end . 216)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 232)\n  (:start . 220) (:id . 78))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 79))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 240) (:start . 236)\n  (:id . 80))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 254) (:start . 241) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1062.6) (:did . :|9231664|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009930@unknown@formal@none@1@S@RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells.@(((:tag . "NNP") (:stem . "RP1") (:form . "RP1") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 10) (:start . 7)\n  (:id . 45))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 17)\n  (:start . 11) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adenomatous") (:form . "adenomatous") (:end . 36)\n  (:start . 25) (:id . 49))\n ((:tag . "NN") (:stem . "polyposis") (:form . "polyposis") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "coli-binding") (:form . "coli-binding") (:end . 59)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "eb1-like") (:form . "EB1-like") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 99) (:start . 85) (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1063.1) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009931@unknown@formal@none@1@S@Cross-linking of the CD3 and CD28 molecules on T lymphocytes represents one of the most effective signals for T lymphocyte activation and triggering of their cytotoxic effector function.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 157)\n  (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 185)\n  (:start . 177) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1063.2) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009932@unknown@formal@none@1@S@To identify genes that are expressed in T cells after stimulation, mRNA from T lymphocytes that had been activated by the simultaneous stimulation of the CD3 and CD28 trigger molecules was transcribed for a differential mRNA display analysis into cDNA and was compared with cDNA from CD28- or CD3-activated or resting lymphocytes.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . 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"VBD") (:stem . "have") (:form . "had") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 134)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 146)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . 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"CD28-") (:end . 289)\n  (:start . 284) (:id . 89))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 292) (:start . 290)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "cd3-activated") (:form . "CD3-activated")\n  (:end . 306) (:start . 293) (:id . 91))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 309) (:start . 307)\n  (:id . 92))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 317)\n  (:start . 310) (:id . 93))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 329)\n  (:start . 318) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 330) (:start . 329)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s1063.3) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009933@unknown@formal@none@1@S@Differential expression was confirmed subsequently by Northern blot analysis.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 50)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 67) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1063.4) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009934@unknown@formal@none@1@S@One of the cDNA fragments expressed specifically in CD3- and CD28-activated T cells was designated RP1.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd3-") (:form . "CD3-") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd28-activated") (:form . "CD28-activated")\n  (:end . 75) (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "rp1") (:form . "RP1") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1063.5) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009935@unknown@formal@none@1@S@The predictive protein-coding region of RP1 had a significant homology to members of the recently found adenomatous polyposis coli (APC) protein-binding EB1 gene family, which codes for yet unknown protein(s).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "protein-coding") (:form . "protein-coding")\n  (:end . 29) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RP1") (:form . "RP1") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adenomatous") (:form . "adenomatous") (:end . 115)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "polyposis") (:form . "polyposis") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "coli") (:form . "coli") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "protein-binding") (:form . "protein-binding")\n  (:end . 152) (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "eb1") (:form . "EB1") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 175)\n  (:start . 170) (:id . 69))\n ((:tag . "VBZ") (:stem . "cod") (:form . "codes") (:end . 181) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 197)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "protein(s)") (:form . "protein(s)") (:end . 208)\n  (:start . 198) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1063.6) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009936@unknown@formal@none@1@S@Bacterially expressed RP1 protein revealed specific binding to wild-type but not to mutated APC protein.@(((:tag . "RB") (:stem . "bacterially") (:form . "Bacterially") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "rp1") (:form . "RP1") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NNP") (:stem . "APC") (:form . "APC") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1063.7.1) (:span 77 80)))\n (:nscopes ((:id . :x1063.7.1) (:span 77 103)))\n (:identifiers (:sid . :s1063.7) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009937@unknown@formal@none@1@S@The rapid up-regulation of RP1 mRNA in properly activated T cells suggests that this gene might belong to the immediate/early gene family, which controls the signal transduction cascade downstream of the TCR.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RP1") (:form . "RP1") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "properly") (:form . "properly") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "VB") (:stem . "belong") (:form . "belong") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "immediate/early") (:form . "immediate/early")\n  (:end . 125) (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 177)\n  (:start . 165) (:id . 69))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 196)\n  (:start . 186) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1063.8.1) (:span 90 95))\n  ((:id . :x1063.8.2) (:span 66 74)))\n (:hscopes ((:id . :x1063.8.1) (:span 90 207))\n  ((:id . :x1063.8.2) (:span 66 207)))\n (:identifiers (:sid . :s1063.8) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009938@unknown@formal@none@1@S@As the expression level of the RP1 gene in activated T cells and a spectrum of tumor-derived cell lines correlates with the proliferative status of the cells, members of the EB1-like gene family may not only be involved in the tumorigenesis of colorectal cancers but may also play a role in the proliferative control of normal cells.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rp1") (:form . 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"cells") (:end . 332)\n  (:start . 327) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 333) (:start . 332)\n  (:id . 100)))@@@1@59@((:hcues ((:id . :x1063.9.1) (:span 267 270))\n  ((:id . :x1063.9.2) (:span 195 198)))\n (:hscopes ((:id . :x1063.9.1) (:span 267 332))\n  ((:id . :x1063.9.2) (:span 195 262)))\n (:identifiers (:sid . :s1063.9) (:did . :|9233623|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009940@unknown@formal@none@1@S@CD28 is an important costimulatory molecule in the activation of human T cells.@(((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1064.2) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009941@unknown@formal@none@1@S@Costimulation of T cells through both the Ag receptor and CD28 leads to high level IL-2 production, which is vital to the development of an immune response in vivo.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ag") (:form . "Ag") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "vital") (:form . "vital") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 133)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 146)\n  (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 155)\n  (:start . 147) (:id . 69))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1064.3) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009942@unknown@formal@none@1@S@Previous reports have suggested the CD28 stimulation contributes to the activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including AP-1 and nuclear factor-kappaB (NF-kappaB)/Rel family members as well as an uncharacterized transcription factor called CD28 response complex.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "up-regulate") (:form . "up-regulating")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 158) (:start . 145) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 166)\n  (:start . 159) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 177)\n  (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 182) (:start . 178)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 194)\n  (:start . 187) (:id . 69))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 208) (:start . 195) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappaB)/Rel") (:form . "NF-kappaB)/Rel")\n  (:end . 224) (:start . 210) (:id . 72))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 231)\n  (:start . 225) (:id . 73))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 239)\n  (:start . 232) (:id . 74))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 242) (:start . 240)\n  (:id . 75))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 247) (:start . 243)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 250) (:start . 248)\n  (:id . 77))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 253) (:start . 251)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "uncharacterized") (:form . "uncharacterized")\n  (:end . 269) (:start . 254) (:id . 79))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 283) (:start . 270) (:id . 80))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 290)\n  (:start . 284) (:id . 81))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 297)\n  (:start . 291) (:id . 82))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 302) (:start . 298)\n  (:id . 83))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 311)\n  (:start . 303) (:id . 84))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 319)\n  (:start . 312) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 320) (:start . 319)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x1064.4.1) (:span 22 31)))\n (:hscopes ((:id . :x1064.4.1) (:span 22 319)))\n (:identifiers (:sid . :s1064.4) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009943@unknown@formal@none@1@S@While several lines of investigation have suggested that NF-kappaB/Rel family members make up the CD28 response complex transcription factor, other work has not supported this conclusion.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 70) (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 140)\n  (:start . 134) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 147)\n  (:start . 142) (:id . 62))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 170)\n  (:start . 161) (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 175) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 186)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1064.5.2) (:span 42 51)))\n (:ncues ((:id . :x1064.5.1) (:span 157 160)))\n (:hscopes ((:id . :x1064.5.2) (:span 42 140)))\n (:nscopes ((:id . :x1064.5.1) (:span 157 186)))\n (:identifiers (:sid . :s1064.5) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009944@unknown@formal@none@1@S@Recent studies suggest that the CD28 response element (CD28RE) does not function independently but works instead in conjunction with the adjacent promoter proximal AP-1-binding site and this hypothesis is confirmed here.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD28RE") (:form . "CD28RE") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "work") (:form . "works") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 176)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 201)\n  (:start . 191) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 214)\n  (:start . 205) (:id . 73))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 219) (:start . 215)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1064.6.2) (:span 15 22)))\n (:ncues ((:id . :x1064.6.1) (:span 68 71)))\n (:hscopes ((:id . :x1064.6.2) (:span 15 181)))\n (:nscopes ((:id . :x1064.6.1) (:span 68 94)))\n (:identifiers (:sid . :s1064.6) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009945@unknown@formal@none@1@S@Also in the current study, binding activity to the CD28RE/AP-1 sequence of the IL-2 promoter is evaluated.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd28re/ap-1") (:form . "CD28RE/AP-1") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1064.7) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009946@unknown@formal@none@1@S@Although four specific complexes can be detected binding to this sequence, only one of these complexes is specific for both the CD28RE and the adjacent AP-1 site.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cd28re") (:form . "CD28RE") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1064.8) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009947@unknown@formal@none@1@S@Of the NF-kappaB/Rel family members tested, this CD28RE/AP-1-specific complex contains predominantly c-Rel, despite the fact that both p50 and RelA can efficiently bind to the CD28RE.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 20) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 42) (:start . 36)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd28re/ap-1-specific")\n  (:form . "CD28RE/AP-1-specific") (:end . 69) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 100) (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 106)\n  (:start . 101) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 55))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 115)\n  (:start . 108) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 124) (:start . 120)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 163)\n  (:start . 152) (:id . 65))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cd28re") (:form . "CD28RE") (:end . 182)\n  (:start . 176) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1064.9) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009948@unknown@formal@none@1@S@c-Fos and c-Jun are also found in this CD28RE/AP-1-specific complex.@(((:tag . "NN") (:stem . "c-fos") (:form . "c-Fos") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd28re/ap-1-specific")\n  (:form . "CD28RE/AP-1-specific") (:end . 59) (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1064.10) (:did . :|9233628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009950@unknown@formal@none@1@S@c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB.@(((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "overcome") (:form . "overcome") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ZEB") (:form . "ZEB") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1065.1) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009951@unknown@formal@none@1@S@The Zfh family of zinc finger/homeodomain proteins was first identified in Drosophila where it is required for differentiation of tissues such as the central nervous system and muscle.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Zfh") (:form . "Zfh") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "finger/homeodomain") (:form . "finger/homeodomain")\n  (:end . 41) (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 126) (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 137)\n  (:start . 130) (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 165)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 172)\n  (:start . 166) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 183)\n  (:start . 177) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1065.2) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009952@unknown@formal@none@1@S@ZEB, a vertebrate homolog of Zfh-1, binds a subset of E boxes and blocks myogenesis through transcriptional repression of muscle genes.@(((:tag . "NNP") (:stem . "ZEB") (:form . "ZEB") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "vertebrate") (:form . "vertebrate") (:end . 17)\n  (:start . 7) (:id . 45))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Zfh-1") (:form . "Zfh-1") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 61) (:start . 56)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 72)\n  (:start . 66) (:id . 57))\n ((:tag . "NN") (:stem . "myogenesis") (:form . "myogenesis") (:end . 83)\n  (:start . 73) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 91)\n  (:start . 84) (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 107) (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 118)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1065.3) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009953@unknown@formal@none@1@S@We present evidence here that ZEB also has an important role in controlling hematopoietic gene transcription.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ZEB") (:form . "ZEB") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1065.4) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009954@unknown@formal@none@1@S@Two families of transcription factors that are required for normal hematopoiesis are c-Myb and Ets.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 80) (:start . 67) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1065.5) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009955@unknown@formal@none@1@S@These factors act synergistically to activate transcription, and this synergy is required for transcription of at least several important hematopoietic genes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 33) (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 107) (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 151) (:start . 138) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 157)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1065.6) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009956@unknown@formal@none@1@S@ZEB blocks the activity of c-Myb and Ets individually, but together the factors synergize to resist this repression.@(((:tag . "NNP") (:stem . "ZEB") (:form . "ZEB") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "RB") (:stem . "individually") (:form . "individually") (:end . 53)\n  (:start . 41) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "VBP") (:stem . "synergize") (:form . "synergize") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "VB") (:stem . "resist") (:form . "resist") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1065.7) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009957@unknown@formal@none@1@S@Such repression imposes a requirement for both c-Myb and Ets for transcriptional activity, providing one explanation for why synergy between these factors is important.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "impose") (:form . "imposes") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-myb") (:form . "c-Myb") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 80) (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 116)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1065.8) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009958@unknown@formal@none@1@S@The balance between repression by ZEB and transcriptional activation by c-Myb/Ets provides a flexible regulatory mechanism for controlling gene expression in hematopoietic cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ZEB") (:form . "ZEB") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "c-myb/ets") (:form . "c-Myb/Ets") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "flexible") (:form . "flexible") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 122)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 154)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 171) (:start . 158) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1065.9) (:did . :|9233802|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009960@unknown@formal@none@1@S@GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.@(((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "c-raf-mediated") (:form . "c-Raf-mediated")\n  (:end . 92) (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1066.1) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009961@unknown@formal@none@1@S@Triggering of the T-cell receptor-CD3 complex activates two major signal cascades in T lymphocytes, (i) Ca2+-dependent signal cascades and (ii) protein kinase cascades.@(((:tag . "NN") (:stem . "triggering") (:form . "Triggering") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "receptor-cd3") (:form . "receptor-CD3") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ca2+-dependent") (:form . "Ca2+-dependent")\n  (:end . 118) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1066.2) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009962@unknown@formal@none@1@S@Both signal cascades contribute to the induction of the interleukin 2 (IL-2) gene during T-cell activation.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1066.3) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009963@unknown@formal@none@1@S@Prominent protein kinase cascades are those that activate mitogen-activated protein (MAP) kinases.@(((:tag . "JJ") (:stem . "prominent") (:form . "Prominent") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 75) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1066.4) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009964@unknown@formal@none@1@S@We show here that c-Raf, which is at the helm of the classic MAP-Erk cascade, contributes to IL-2 induction through a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-raf") (:form . "c-Raf") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "helm") (:form . "helm") (:end . 45) (:start . 41)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "classic") (:form . "classic") (:end . 60)\n  (:start . 53) (:id . 55))\n ((:tag . "NNP") (:stem . "MAP-Erk") (:form . "MAP-Erk") (:end . 68)\n  (:start . 61) (:id . 56))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 76)\n  (:start . 69) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 89)\n  (:start . 78) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 97) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 107)\n  (:start . 98) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 124)\n  (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 133)\n  (:start . 125) (:id . 66))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "VBG") (:stem . "span") (:form . "spanning") (:end . 150)\n  (:start . 142) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 166)\n  (:start . 155) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 181)\n  (:start . 172) (:id . 72))\n ((:tag . "CD") (:stem . "-502") (:form . "-502") (:end . 186) (:start . 182)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 189) (:start . 187)\n  (:id . 74))\n ((:tag . "CD") (:stem . "-413") (:form . "-413") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 76))\n ((:tag . "NN") (:stem . "front") (:form . "front") (:end . 203)\n  (:start . 198) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 226) (:start . 211) (:id . 80))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 232)\n  (:start . 227) (:id . 81))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 237) (:start . 233)\n  (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 240) (:start . 238)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 84))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 249) (:start . 245)\n  (:id . 85))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 254) (:start . 250)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1066.5) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009965@unknown@formal@none@1@S@Induction of this distal IL-2 enhancer differs from induction of the proximal IL-2 promoter-enhancer, since it is induced by phorbol esters alone and independent from Ca2+ signals.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter-enhancer") (:form . "promoter-enhancer")\n  (:end . 100) (:start . 83) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 161)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 179)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1066.6) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009966@unknown@formal@none@1@S@In DNA-protein binding studies, we detected the binding of transcription factors GABP alpha and -beta to a dyad symmetry element (DSE) of the distal enhancer, which is formed by palindromic binding sites of Ets-like factors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "-beta") (:form . "-beta") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dyad") (:form . "dyad") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "symmetry") (:form . "symmetry") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 148)\n  (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 157)\n  (:start . 149) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 164)\n  (:start . 159) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 174)\n  (:start . 168) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "palindromic") (:form . "palindromic") (:end . 189)\n  (:start . 178) (:id . 75))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 197)\n  (:start . 190) (:id . 76))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 203)\n  (:start . 198) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "ets-like") (:form . "Ets-like") (:end . 215)\n  (:start . 207) (:id . 79))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 223)\n  (:start . 216) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1066.7) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009967@unknown@formal@none@1@S@Introduction of point mutations suppressing GABP binding to the DSE interfered with the induction of the distal enhancer and the entire IL-2 promoter-enhancer, while overexpression of both GABP factors enhanced the IL-2 promoter-enhancer induction.@(((:tag . "NN") (:stem . "introduction") (:form . "Introduction") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "interfere") (:form . "interfered") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "promoter-enhancer") (:form . "promoter-enhancer")\n  (:end . 158) (:start . 141) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 180) (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 188) (:start . 184)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GABP") (:form . "GABP") (:end . 193) (:start . 189)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 201)\n  (:start . 194) (:id . 71))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 210)\n  (:start . 202) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 219) (:start . 215)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "promoter-enhancer") (:form . "promoter-enhancer")\n  (:end . 237) (:start . 220) (:id . 75))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 247)\n  (:start . 238) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1066.8) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009968@unknown@formal@none@1@S@Overexpression of BXB, a constitutive active version of c-Raf, and of further members of the Ras-Raf-Erk signal cascade exerted an increase of GABP-mediated promoter-enhancer induction.@(((:tag . "NNP") (:stem . "Overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "BXB") (:form . "BXB") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "c-raf") (:form . "c-Raf") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ras-Raf-Erk") (:form . "Ras-Raf-Erk") (:end . 104)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "VBD") (:stem . "exert") (:form . "exerted") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "gabp-mediated") (:form . "GABP-mediated")\n  (:end . 156) (:start . 143) (:id . 66))\n ((:tag . "JJ") (:stem . "promoter-enhancer") (:form . "promoter-enhancer")\n  (:end . 174) (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 184)\n  (:start . 175) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1066.9) (:did . :|9234696|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009970@unknown@formal@none@1@S@The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "extra") (:form . "extra") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "comb") (:form . "combs") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "display") (:form . "displays") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 97) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1067.1) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009971@unknown@formal@none@1@S@The heterogeneous nuclear ribonucleoprotein K protein represents a novel class of proteins that may act as docking platforms that orchestrate cross-talk among molecules involved in signal transduction and gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "ribonucleoprotein") (:form . "ribonucleoprotein")\n  (:end . 43) (:start . 26) (:id . 45))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 45) (:start . 44)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 64)\n  (:start . 54) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "docking") (:form . "docking") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "platform") (:form . "platforms") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "orchestrate") (:form . "orchestrate") (:end . 141)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "cross-talk") (:form . "cross-talk") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 158)\n  (:start . 153) (:id . 63))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 168)\n  (:start . 159) (:id . 64))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 177)\n  (:start . 169) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 187)\n  (:start . 181) (:id . 67))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 200)\n  (:start . 188) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 209) (:start . 205)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 220)\n  (:start . 210) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1067.2.1) (:span 96 99)))\n (:hscopes ((:id . :x1067.2.1) (:span 96 220)))\n (:identifiers (:sid . :s1067.2) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009972@unknown@formal@none@1@S@Using a fragment of K protein as bait in the yeast two-hybrid screen, we isolated a cDNA that encodes a protein whose primary structure has extensive similarity to the Drosophila melanogaster extra sex combs (esc) gene product, Esc, a putative silencer of homeotic genes.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bait") (:form . "bait") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 101)\n  (:start . 94) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 111)\n  (:start . 104) (:id . 63))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 125)\n  (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 135)\n  (:start . 126) (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 149)\n  (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 160)\n  (:start . 150) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . "FW") (:stem . "melanogaster") (:form . "melanogaster") (:end . 191)\n  (:start . 179) (:id . 73))\n ((:tag . "JJ") (:stem . "extra") (:form . "extra") (:end . 197)\n  (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "comb") (:form . "combs") (:end . 207)\n  (:start . 202) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 209) (:start . 208)\n  (:id . 77))\n ((:tag . "NN") (:stem . "esc") (:form . "esc") (:end . 212) (:start . 209)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 218) (:start . 214)\n  (:id . 80))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 226)\n  (:start . 219) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 227) (:start . 226)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Esc") (:form . "Esc") (:end . 231) (:start . 228)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 232) (:start . 231)\n  (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 234) (:start . 233)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 243)\n  (:start . 235) (:id . 86))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 252)\n  (:start . 244) (:id . 87))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 255) (:start . 253)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "homeotic") (:form . "homeotic") (:end . 264)\n  (:start . 256) (:id . 89))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 270)\n  (:start . 265) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s1067.3) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009973@unknown@formal@none@1@S@The cDNA that we isolated is identical to the cDNA of the recently positionally cloned mouse embryonic ectoderm development gene, eed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . "RB") (:stem . "positionally") (:form . "positionally") (:end . 79)\n  (:start . 67) (:id . 55))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "ectoderm") (:form . "ectoderm") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "eed") (:form . "eed") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1067.4) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009974@unknown@formal@none@1@S@Like Esc, Eed contains six WD-40 repeats in the C-terminal half of the protein and is thought to repress homeotic gene expression during mouse embryogenesis.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Esc") (:form . "Esc") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "Eed") (:form . "Eed") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 22)\n  (:start . 14) (:id . 46))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wd-40") (:form . "WD-40") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 93)\n  (:start . 86) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 104)\n  (:start . 97) (:id . 61))\n ((:tag . "JJ") (:stem . "homeotic") (:form . "homeotic") (:end . 113)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "embryogenesis") (:form . "embryogenesis")\n  (:end . 156) (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1067.5.1) (:span 86 93)))\n (:hscopes ((:id . :x1067.5.1) (:span 83 156)))\n (:identifiers (:sid . :s1067.5) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009975@unknown@formal@none@1@S@Eed binds to K protein through a domain in its N terminus, but interestingly, this domain is not found in the Drosophila Esc.@(((:tag . "NN") (:stem . "eed") (:form . "Eed") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 57)\n  (:start . 49) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "RB") (:stem . "interestingly") (:form . "interestingly")\n  (:end . 76) (:start . 63) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 102) (:start . 97)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 120)\n  (:start . 110) (:id . 65))\n ((:tag . "NNP") (:stem . "Esc") (:form . "Esc") (:end . 124) (:start . 121)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1067.6.1) (:span 93 96)))\n (:nscopes ((:id . :x1067.6.1) (:span 78 124)))\n (:identifiers (:sid . :s1067.6) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009976@unknown@formal@none@1@S@Gal4-Eed fusion protein represses transcription of a reporter gene driven by a promoter that contains Gal4-binding DNA elements.@(((:tag . "JJ") (:stem . "gal4-eed") (:form . "Gal4-Eed") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "gal4-binding") (:form . "Gal4-binding") (:end . 114)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1067.7) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009977@unknown@formal@none@1@S@Eed also represses transcription when recruited to a target promoter by Gal4-K protein.@(((:tag . "NNP") (:stem . "Eed") (:form . "Eed") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "repress") (:form . "represses") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Gal4-K") (:form . "Gal4-K") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1067.8) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009978@unknown@formal@none@1@S@Point mutations within the eed gene that are responsible for severe embryonic development abnormalities abolished the transcriptional repressor activity of Eed.@(((:tag . "NNP") (:stem . "Point") (:form . "Point") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "eed") (:form . "eed") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities")\n  (:end . 103) (:start . 90) (:id . 55))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 133) (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 143)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Eed") (:form . "Eed") (:end . 159) (:start . 156)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1067.9) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009980@unknown@formal@none@1@S@The Eed-mediated transcriptional effects are likely to reflect the interaction of Eed with multiple molecular partners, including K protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "eed-mediated") (:form . "Eed-mediated") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 32) (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "eed") (:form . "Eed") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1067.11.1) (:span 45 51)))\n (:hscopes ((:id . :x1067.11.1) (:span 0 139)))\n (:identifiers (:sid . :s1067.11) (:did . :|9234727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009981@unknown@formal@none@1@S@Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.@(((:tag . "JJ") (:stem . "opposite") (:form . "Opposite") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "pml-retinoic") (:form . "PML-retinoic") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PLZF-RAR") (:form . "PLZF-RAR") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 160)\n  (:start . 150) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1068.1) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009982@unknown@formal@none@1@S@Fusion proteins involving the retinoic acid receptor alpha (RAR alpha) and the PML or PLZF nuclear protein are the genetic markers of acute promyelocytic leukemias (APLs).@(((:tag . "NN") (:stem . "fusion") (:form . "Fusion") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PML") (:form . "PML") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PLZF") (:form . "PLZF") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 139)\n  (:start . 134) (:id . 66))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 153) (:start . 140) (:id . 67))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 163)\n  (:start . 154) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "APL") (:form . "APLs") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1068.2) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009983@unknown@formal@none@1@S@APLs with the PML-RAR alpha or the PLZF-RAR alpha fusion protein are phenotypically indistinguishable except that they differ in their sensitivity to retinoic acid (RA)-induced differentiation: PML-RAR alpha blasts are sensitive to RA and patients enter disease remission after RA treatment, while patients with PLZF-RAR alpha do not.@(((:tag . "NNS") (:stem . "apl") (:form . "APLs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pml-rar") (:form . "PML-RAR") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"with") (:end . 311) (:start . 307)\n  (:id . 88))\n ((:tag . "NN") (:stem . "plzf-rar") (:form . "PLZF-RAR") (:end . 320)\n  (:start . 312) (:id . 89))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 326)\n  (:start . 321) (:id . 90))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 329) (:start . 327)\n  (:id . 91))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 333) (:start . 330)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 334) (:start . 333)\n  (:id . 93)))@@@1@52@((:ncues ((:id . :x1068.3.1) (:span 330 333)))\n (:nscopes ((:id . :x1068.3.1) (:span 330 333)))\n (:identifiers (:sid . :s1068.3) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009984@unknown@formal@none@1@S@We here report that (i) like PML-RAR alpha expression, PLZF-RAR alpha expression blocks terminal differentiation of hematopoietic precursor cell lines (U937 and HL-60) in response to different stimuli (vitamin D3, transforming growth factor beta1, and dimethyl sulfoxide); (ii) PML-RAR alpha, but not PLZF-RAR alpha, increases RA sensitivity of hematopoietic precursor cells and restores RA sensitivity of RA-resistant hematopoietic cells; (iii) PML-RAR alpha and PLZF-RAR alpha have similar RA binding affinities; and (iv) PML-RAR alpha enhances the RA response of RA target genes (those for RAR beta, RAR gamma, and transglutaminase type II [TGase]) in vivo, while PLZF-RAR alpha expression has either no effect (RAR beta) or an inhibitory activity (RAR gamma and type II TGase).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "here") (:form . 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5009985@unknown@formal@none@1@S@These data demonstrate that PML-RAR alpha and PLZF-RAR alpha have similar (inhibitory) effects on RA-independent differentiation and opposite (stimulatory or inhibitory) effects on RA-dependent differentiation and that they behave in vivo as RA-dependent enhancers or inhibitors of RA-responsive genes, respectively.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pml-rar") (:form . "PML-RAR") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "plzf-rar") (:form . "PLZF-RAR") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ra-independent") (:form . "RA-independent")\n  (:end . 112) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 128) (:start . 113) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 154)\n  (:start . 143) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 168)\n  (:start . 158) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 177)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "ra-dependent") (:form . "RA-dependent") (:end . 193)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 209) (:start . 194) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 218) (:start . 214)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 223) (:start . 219)\n  (:id . 73))\n ((:tag . "VBP") (:stem . "behave") (:form . "behave") (:end . 230)\n  (:start . 224) (:id . 74))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 75))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 238) (:start . 234)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 241) (:start . 239)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "ra-dependent") (:form . "RA-dependent") (:end . 254)\n  (:start . 242) (:id . 78))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 264)\n  (:start . 255) (:id . 79))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 267) (:start . 265)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 278)\n  (:start . 268) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 281) (:start . 279)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "ra-responsive") (:form . "RA-responsive")\n  (:end . 295) (:start . 282) (:id . 83))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 301)\n  (:start . 296) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 302) (:start . 301)\n  (:id . 85))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 315)\n  (:start . 303) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1068.5) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009986@unknown@formal@none@1@S@Their different activities on the RA signalling pathway might underlie the different responses of PML-RAR alpha and PLZF-RAR alpha APLs to RA treatment.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pml-rar") (:form . "PML-RAR") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "plzf-rar") (:form . "PLZF-RAR") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "apl") (:form . "APLs") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1068.6.1) (:span 56 61)))\n (:hscopes ((:id . :x1068.6.1) (:span 56 151)))\n (:identifiers (:sid . :s1068.6) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009987@unknown@formal@none@1@S@The PLZF-RAR alpha fusion protein contains an approximately 120-amino-acid N-terminal motif (called the POZ domain), which is also found in a variety of zinc finger proteins and a group of poxvirus proteins and which mediates protein-protein interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PLZF-RAR") (:form . "PLZF-RAR") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "120-amino-acid") (:form . "120-amino-acid")\n  (:end . 74) (:start . 60) (:id . 50))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 85)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 91) (:start . 86)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 99) (:start . 93)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "POZ") (:form . "POZ") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 114)\n  (:start . 108) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 185)\n  (:start . 180) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "poxvirus") (:form . "poxvirus") (:end . 197)\n  (:start . 189) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 206)\n  (:start . 198) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 77))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 216)\n  (:start . 211) (:id . 78))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 225)\n  (:start . 217) (:id . 79))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 241) (:start . 226) (:id . 80))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 254)\n  (:start . 242) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1068.7) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009988@unknown@formal@none@1@S@Deletion of the PLZF POZ domain partially abrogated the inhibitory effect of PLZF-RAR alpha on RA-induced differentiation and on RA-mediated type II TGase up-regulation, suggesting that POZ-mediated protein interactions might be responsible for the inhibitory transcriptional activities of PLZF-RAR alpha.@(((:tag . "NN") (:stem . "deletion") (:form . "Deletion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PLZF") (:form . "PLZF") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "POZ") (:form . "POZ") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "plzf-rar") (:form . "PLZF-RAR") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ra-induced") (:form . "RA-induced") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 121) (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "ra-mediated") (:form . "RA-mediated") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TGase") (:form . "TGase") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 168) (:start . 155) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "poz-mediated") (:form . "POZ-mediated") (:end . 198)\n  (:start . 186) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 206)\n  (:start . 199) (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 219)\n  (:start . 207) (:id . 71))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 225)\n  (:start . 220) (:id . 72))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 228) (:start . 226)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 240)\n  (:start . 229) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 244) (:start . 241)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 248) (:start . 245)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 259)\n  (:start . 249) (:id . 77))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 275) (:start . 260) (:id . 78))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 286)\n  (:start . 276) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 289) (:start . 287)\n  (:id . 80))\n ((:tag . "NN") (:stem . "plzf-rar") (:form . "PLZF-RAR") (:end . 298)\n  (:start . 290) (:id . 81))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 304)\n  (:start . 299) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1068.8.1) (:span 220 225))\n  ((:id . :x1068.8.2) (:span 170 180)))\n (:hscopes ((:id . :x1068.8.1) (:span 220 304))\n  ((:id . :x1068.8.2) (:span 170 304)))\n (:identifiers (:sid . :s1068.8) (:did . :|9234742|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009990@unknown@formal@none@1@S@Because candidiasis and cryptococcosis are common in human immunodeficiency virus (HIV)-infected persons, the effect of Cryptococcus neoformans and Candida albicans on HIV expression in monocytic cells was examined.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "candidiasis") (:form . "candidiasis") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cryptococcosis") (:form . "cryptococcosis")\n  (:end . 38) (:start . 24) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 75) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 81) (:start . 76)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "HIV)-infected") (:form . "HIV)-infected")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . "NNS") (:stem . "person") (:form . "persons") (:end . 104)\n  (:start . 97) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "FW") (:stem . "cryptococcus") (:form . "Cryptococcus") (:end . 132)\n  (:start . 120) (:id . 59))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 143)\n  (:start . 133) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 61))\n ((:tag . "FW") (:stem . "candida") (:form . "Candida") (:end . 155)\n  (:start . 148) (:id . 62))\n ((:tag . "FW") (:stem . "albicans") (:form . "albicans") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 182)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 195)\n  (:start . 186) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 201)\n  (:start . 196) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 205) (:start . 202)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 214)\n  (:start . 206) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1069.2) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009991@unknown@formal@none@1@S@Stimulation of the latently HIV-infected myelomonocytic cell line OM-10.1 with C. neoformans and C. albicans in the presence of pooled human serum caused a ratio-dependent increase in HIV production.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "myelomonocytic") (:form . "myelomonocytic")\n  (:end . 55) (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 65) (:start . 61)\n  (:id . 49))\n ((:tag . "NN") (:stem . "om-10.1") (:form . "OM-10.1") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 51))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "FW") (:stem . "albicans") (:form . "albicans") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "pool") (:form . "pooled") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 153)\n  (:start . 147) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "ratio-dependent") (:form . "ratio-dependent")\n  (:end . 171) (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 180)\n  (:start . 172) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 187) (:start . 184)\n  (:id . 69))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 198)\n  (:start . 188) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1069.3) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009992@unknown@formal@none@1@S@Induction of HIV by C. neoformans was enhanced by anti-capsular antibody, while induction by both organisms was inhibited by anti-TNF-alpha antibody.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-capsular") (:form . "anti-capsular")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-tnf-alpha") (:form . "anti-TNF-alpha")\n  (:end . 139) (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1069.4) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009993@unknown@formal@none@1@S@In THP-1 cells transfected with HIV plasmid constructs, both organisms induced transcription from the HIV long terminal repeat that was dependent on intact NF-kappaB binding sequences.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 165)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 173)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 183)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1069.5) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009994@unknown@formal@none@1@S@Thus, C. neoformans and C. albicans enhance HIV expression in monocytic cells through a TNF-alpha- and NF-kappaB-dependent mechanism.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "FW") (:stem . "neoformans") (:form . "neoformans") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "FW") (:stem . "c.") (:form . "C.") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "FW") (:stem . "albicans") (:form . "albicans") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "VBP") (:stem . "enhance") (:form . "enhance") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF-alpha-") (:form . "TNF-alpha-") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 122) (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1069.6) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009995@unknown@formal@none@1@S@In HIV-infected patients, such enhancement may further impair host immunity and could accelerate the course of HIV disease.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "VB") (:stem . "impair") (:form . "impair") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "VB") (:stem . "accelerate") (:form . "accelerate") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1069.7.1) (:span 80 85))\n  ((:id . :x1069.7.2) (:span 43 46)))\n (:hscopes ((:id . :x1069.7.1) (:span 80 122))\n  ((:id . :x1069.7.2) (:span 43 75)))\n (:identifiers (:sid . :s1069.7) (:did . :|9237716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009996@unknown@formal@none@1@S@A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments]@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "VBZ") (:stem . "signal") (:form . "signals") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "adaptive") (:form . "adaptive") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1070.1) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5009997@unknown@formal@none@1@S@Induction of the adaptive immune response depends on the expression of co-stimulatory molecules and cytokines by antigen-presenting cells.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adaptive") (:form . "adaptive") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "co-stimulatory") (:form . "co-stimulatory")\n  (:end . 85) (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 131) (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1070.2) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5009998@unknown@formal@none@1@S@The mechanisms that control the initial induction of these signals upon infection are poorly understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1070.3) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010000@unknown@formal@none@1@S@We report here the cloning and characterization of a human homologue of the Drosophila toll protein (Toll) which has been shown to induce the innate immune response in adult Drosophila.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 47) (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "toll") (:form . "toll") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 137)\n  (:start . 131) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 148)\n  (:start . 142) (:id . 68))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 155)\n  (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 173)\n  (:start . 168) (:id . 72))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 184)\n  (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1070.5) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010001@unknown@formal@none@1@S@Like Drosophila Toll, human Toll is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat (LRR) domain, and a cytoplasmic domain homologous to the cytoplasmic domain of the human interleukin (IL)-1 receptor.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 58) (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 88) (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "leucine-rich") (:form . "leucine-rich") (:end . 124)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "LRR") (:form . "LRR") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 163)\n  (:start . 152) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 170)\n  (:start . 164) (:id . 71))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 181)\n  (:start . 171) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 200)\n  (:start . 189) (:id . 75))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 207)\n  (:start . 201) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 220)\n  (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 232)\n  (:start . 221) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 234) (:start . 233)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "IL)-1") (:form . "IL)-1") (:end . 239)\n  (:start . 234) (:id . 82))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 248)\n  (:start . 240) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1070.6) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010002@unknown@formal@none@1@S@Both Drosophila Toll and the IL-1 receptor are known to signal through the NF-kappaB pathway.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VB") (:stem . "signal") (:form . "signal") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1070.7) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010003@unknown@formal@none@1@S@We show that a constitutively active mutant of human Toll transfected into human cell lines can induce the activation of NF-kappaB and the expression of NF-kappaB-controlled genes for the inflammatory cytokines IL-1, IL-6 and IL-8, as well as the expression of the co-stimulatory molecule B7.1, which is required for the activation of naive T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 29) (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nf-kappab-controlled")\n  (:form . "NF-kappaB-controlled") (:end . 173) (:start . 153) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 183) (:start . 180)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 200)\n  (:start . 188) (:id . 71))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 210)\n  (:start . 201) (:id . 72))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 215) (:start . 211)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 221) (:start . 217)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 230) (:start . 226)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 231) (:start . 230)\n  (:id . 78))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 234) (:start . 232)\n  (:id . 79))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 239) (:start . 235)\n  (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 242) (:start . 240)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 257)\n  (:start . 247) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 260) (:start . 258)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 264) (:start . 261)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "co-stimulatory") (:form . "co-stimulatory")\n  (:end . 279) (:start . 265) (:id . 86))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 288)\n  (:start . 280) (:id . 87))\n ((:tag . "NN") (:stem . "b7.1") (:form . "B7.1") (:end . 293) (:start . 289)\n  (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 294) (:start . 293)\n  (:id . 89))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 300)\n  (:start . 295) (:id . 90))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 303) (:start . 301)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 312)\n  (:start . 304) (:id . 92))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 316) (:start . 313)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 320) (:start . 317)\n  (:id . 94))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 331)\n  (:start . 321) (:id . 95))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 334) (:start . 332)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 340)\n  (:start . 335) (:id . 97))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 342) (:start . 341)\n  (:id . 98))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 348)\n  (:start . 343) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 349) (:start . 348)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s1070.8) (:did . :|9237759|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010004@unknown@formal@none@1@S@Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells.@(((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "bufalin-induced") (:form . "bufalin-induced")\n  (:end . 38) (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 48)\n  (:start . 39) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 56)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 67)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 88) (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 103)\n  (:start . 97) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 55))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 132)\n  (:start . 124) (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 137) (:start . 133)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1071.1) (:did . :|9242431|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010005@unknown@formal@none@1@S@In a previous study, we demonstrated that bufalin, which is an active principle of Chinese medicine, chan'su, caused apoptosis in human leukemia U937 cells by anomalous activation of mitogen-activated protein kinase (MAPK) via the signaling pathway of Ras, Raf-1, and MAPK kinase-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 13)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 36)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . 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5010006@unknown@formal@none@1@S@Here, we report the effect of overexpression of bcl-2 in U937 cells on the signaling pathway of apoptosis that is induced by bufalin.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 44) (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "bcl-2") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 121)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "bufalin") (:form . "bufalin") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1071.3) (:did . :|9242431|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010007@unknown@formal@none@1@S@The results indicated that the apoptosis induced by bufalin in U937 cells was significantly inhibited by overexpression of the Bcl-2 protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bufalin") (:form . "bufalin") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 91) (:start . 78) (:id . 55))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 119) (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1071.4.1) (:span 12 26)))\n (:hscopes ((:id . :x1071.4.1) (:span 12 140)))\n (:identifiers (:sid . :s1071.4) (:did . :|9242431|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010008@unknown@formal@none@1@S@No significant difference was detected in the activation of MAPK kinase-1 that is induced by bufalin in wild-type or Bcl-2-overexpressed U937 cells; however, the activation of MAPK by bufalin was significantly attenuated in the cells overexpressing Bcl-2.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kinase-1") (:form . "kinase-1") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bufalin") (:form . "bufalin") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "bcl-2-overexpressed")\n  (:form . "Bcl-2-overexpressed") (:end . 136) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "bufalin") (:form . "bufalin") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 209) (:start . 196) (:id . 74))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 220)\n  (:start . 210) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 233)\n  (:start . 228) (:id . 78))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 248) (:start . 234) (:id . 79))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 254)\n  (:start . 249) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1071.5.1) (:span 0 2)))\n (:nscopes ((:id . :x1071.5.1) (:span 0 147)))\n (:identifiers (:sid . :s1071.5) (:did . :|9242431|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010010@unknown@formal@none@1@S@These results indicate that Bcl-2 acts downstream of MAPK kinase-1 but upstream of MAPK and suggest that, in the signaling pathway of the apoptotic process induced by bufalin, the transcriptional activity of activator protein-1 may be down-regulated through the inhibition of MAPK activity by Bcl-2.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "downstream") (:form . 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5010011@unknown@formal@none@1@S@A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "shorten") (:form . "shortened") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "span") (:form . "span") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "eklf-/-") (:form . "EKLF-/-") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "ameliorate") (:form . "ameliorated") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 132)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1072.1) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010012@unknown@formal@none@1@S@Using homologous recombination, both EKLF alleles in murine embryonic stem (ES) cells were inactivated.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "eklf") (:form . "EKLF") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "inactivate") (:form . "inactivated") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1072.2) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010013@unknown@formal@none@1@S@These EKLF-/- ES cells were capable of undergoing in vitro differentiation to form definitive erythroid colonies that were similar in size and number to those formed by wild-type ES cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "eklf-/-") (:form . "EKLF-/-") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 74) (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "definitive") (:form . "definitive") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 165)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 178)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "es") (:form . "ES") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1072.3) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010014@unknown@formal@none@1@S@However, the EKLF-/- colonies were poorly hemoglobinized and enucleated erythrocytes in these colonies contained numerous Heinz bodies.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "eklf-/-") (:form . "EKLF-/-") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "VBN") (:stem . "hemoglobinize") (:form . "hemoglobinized")\n  (:end . 56) (:start . 42) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "enucleate") (:form . "enucleated") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 84)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 121)\n  (:start . 113) (:id . 57))\n ((:tag . "NNP") (:stem . "Heinz") (:form . "Heinz") (:end . 127)\n  (:start . 122) (:id . 58))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1072.4) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010015@unknown@formal@none@1@S@Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that adult and embryonic globin genes were appropriately regulated, with the exception of beta h1-globin, which continued to be expressed at a very low level.@(((:tag . "JJ") (:stem . "reverse") (:form . "Reverse") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 32) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 38) (:start . 33)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 47)\n  (:start . 39) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 55)\n  (:start . 49) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 106)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "RB") (:stem . "appropriately") (:form . "appropriately")\n  (:end . 131) (:start . 118) (:id . 58))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 141)\n  (:start . 132) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 161)\n  (:start . 152) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "beta") (:form . "beta") (:end . 169) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "h1-globin") (:form . "h1-globin") (:end . 179)\n  (:start . 170) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 186)\n  (:start . 181) (:id . 68))\n ((:tag . "VBD") (:stem . "continue") (:form . "continued") (:end . 196)\n  (:start . 187) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 199) (:start . 197)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 212)\n  (:start . 203) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 215) (:start . 213)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 217) (:start . 216)\n  (:id . 74))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 222) (:start . 218)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 226) (:start . 223)\n  (:id . 76))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 232)\n  (:start . 227) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x1072.5.1) (:span 143 164)))\n (:nscopes ((:id . :x1072.5.1) (:span 143 232)))\n (:identifiers (:sid . :s1072.5) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010016@unknown@formal@none@1@S@The ratio of adult beta-globin/alpha-globin mRNA in the mutant ES cells was 1/15 of that in wild-type ES cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-globin/alpha-globin")\n  (:form . "beta-globin/alpha-globin") (:end . 43) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1/15") (:form . "1/15") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "es") (:form . "ES") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1072.6) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010017@unknown@formal@none@1@S@When the EKLF-/- cells were injected into blastocysts, they did not contribute at a detectable level to the mature erythrocyte compartment of the chimeric animals, based on analysis of glucose phosphate isomerase-1 (GPI-1) isozymes and hemoglobins that distinguish ES cell-derived erythrocytes from host blastocyst-derived erythrocytes.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "eklf-/-") (:form . "EKLF-/-") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "inject") (:form . "injected") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . 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5010020@unknown@formal@none@1@S@Consistent with this hypothesis, the short life span was ameliorated by introduction into the EKLF-/- ES cells of a human LCR/gamma-globin gene, as evidenced by the presence of ES cell-derived reticulocytes as well as mature erythrocytes in the blood of the chimeric animals.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "span") (:form . "span") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "ameliorate") (:form . "ameliorated") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "introduction") (:form . "introduction") (:end . 84)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "eklf-/-") (:form . "EKLF-/-") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "LCR/gamma-globin") (:form . "LCR/gamma-globin")\n  (:end . 138) (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ES") (:form . "ES") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "cell-derived") (:form . "cell-derived") (:end . 192)\n  (:start . 180) (:id . 73))\n ((:tag . "NNS") (:stem . "reticulocyte") (:form . "reticulocytes")\n  (:end . 206) (:start . 193) (:id . 74))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 209) (:start . 207)\n  (:id . 75))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 217) (:start . 215)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 224)\n  (:start . 218) (:id . 78))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 237)\n  (:start . 225) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 81))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 250)\n  (:start . 245) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 253) (:start . 251)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 257) (:start . 254)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 266)\n  (:start . 258) (:id . 85))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 274)\n  (:start . 267) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1072.10) (:did . :|9242564|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010021@unknown@formal@none@1@S@Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-hla") (:form . "anti-HLA") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1073.1) (:did . :|9243748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010022@unknown@formal@none@1@S@Monoclonal antibodies against either monomorphic or polymorphic determinants of class I antigen induced in PBMC and highly purified T lymphocytes the nuclear activity of NF-kappa B/Rel complexes.@(((:tag . "JJ") (:stem . "monoclonal") (:form . "Monoclonal") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "monomorphic") (:form . "monomorphic") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "polymorphic") (:form . "polymorphic") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 76)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 85) (:start . 80)\n  (:id . 51))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 87) (:start . 86)\n  (:id . 52))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 103)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 145)\n  (:start . 134) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 157)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 166)\n  (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 178)\n  (:start . 170) (:id . 66))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 184)\n  (:start . 179) (:id . 67))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 194)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1073.2) (:did . :|9243748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010023@unknown@formal@none@1@S@These included both p50/p50 and p50/p65 dimers, recognized by specific antibodies in EMSA.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1073.3) (:did . :|9243748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010024@unknown@formal@none@1@S@The induced complexes were detectable in extracts of cells incubated with anti-class I monoclonal antibody (mAb) for 1.5 h; the induction was maximal at 5 h, persistent at 16 h and no longer observed at 40 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-class") (:form . "anti-class") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1.5") (:form . "1.5") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 168)\n  (:start . 158) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 174) (:start . 172)\n  (:id . 74))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 176) (:start . 175)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 76))\n ((:tag . "RB") (:stem . "no") (:form . "no") (:end . 183) (:start . 181)\n  (:id . 77))\n ((:tag . "RBR") (:stem . "longer") (:form . "longer") (:end . 190)\n  (:start . 184) (:id . 78))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 199)\n  (:start . 191) (:id . 79))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 202) (:start . 200)\n  (:id . 80))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 205) (:start . 203)\n  (:id . 81))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 207) (:start . 206)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x1073.4.1) (:span 181 190)))\n (:nscopes ((:id . :x1073.4.1) (:span 181 207)))\n (:identifiers (:sid . :s1073.4) (:did . :|9243748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010025@unknown@formal@none@1@S@The mAb failed to induce NF-kappa B/Rel nuclear activity in cells incubated in the presence of 3,4-dichloroisocoumarin, an inhibitor of I kappa B-alpha degradation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "3,4-dichloroisocoumarin")\n  (:form . "3,4-dichloroisocoumarin") (:end . 118) (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 163)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1073.5.1) (:span 8 14)))\n (:nscopes ((:id . :x1073.5.1) (:span 8 163)))\n (:identifiers (:sid . :s1073.5) (:did . :|9243748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010026@unknown@formal@none@1@S@Together, these results suggest that class I triggering can induce the activity of NF-kappa B/Rel nuclear activity in peripheral blood T lymphocytes, thereby modulating the expression of genes regulated by these transcription factors.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 148)\n  (:start . 137) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 183)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 192)\n  (:start . 187) (:id . 71))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 202)\n  (:start . 193) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 211)\n  (:start . 206) (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 225) (:start . 212) (:id . 75))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 233)\n  (:start . 226) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1073.6.1) (:span 24 31)))\n (:hscopes ((:id . :x1073.6.1) (:span 24 233)))\n (:identifiers (:sid . :s1073.6) (:did . :|9243748|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010027@unknown@formal@none@1@S@Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p105/nf-kappa") (:form . "p105/NF-kappa")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1074.1.1) (:span 86 89)))\n (:nscopes ((:id . :x1074.1.1) (:span 86 140)))\n (:identifiers (:sid . :s1074.1) (:did . :|9247567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010028@unknown@formal@none@1@S@The transcription factor NF-kappa B controls the induction of numerous cytokine promoters during the activation of T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 128)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1074.2) (:did . :|9247567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010030@unknown@formal@none@1@S@We show for human Jurkat T leukemia cells, as well as human and mouse primary T lymphocytes, that this inhibitory effect is accompanied by an impaired nuclear translocation of the Rel proteins c-Rel, RelA/p65 and NF-kappa B1/p50, whereas the nuclear appearance of RelB remains unaffected.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . 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"NF-kappa") (:end . 221)\n  (:start . 213) (:id . 80))\n ((:tag . "NNP") (:stem . "B1/p50") (:form . "B1/p50") (:end . 228)\n  (:start . 222) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 229) (:start . 228)\n  (:id . 82))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 237)\n  (:start . 230) (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 249)\n  (:start . 242) (:id . 85))\n ((:tag . "NN") (:stem . "appearance") (:form . "appearance") (:end . 260)\n  (:start . 250) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 263) (:start . 261)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "RelB") (:form . "RelB") (:end . 268) (:start . 264)\n  (:id . 88))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 276)\n  (:start . 269) (:id . 89))\n ((:tag . "JJ") (:stem . "unaffected") (:form . 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5010031@unknown@formal@none@1@S@CsA does not interfere with the synthesis of Rel proteins, but prevents the inducible degradation of cytosolic NF-kappa B inhibitors I kappa B alpha and I kappa B beta upon T cell activation.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "interfere") (:form . "interfere") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 97)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 132)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 160)\n  (:start . 155) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 179) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 190)\n  (:start . 180) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1074.5.1) (:span 9 12)))\n (:nscopes ((:id . :x1074.5.1) (:span 9 57)))\n (:identifiers (:sid . :s1074.5) (:did . :|9247567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010032@unknown@formal@none@1@S@CsA neither inhibits the processing of the NF-kappa B1 precursor p105 to p50, nor does it "stabilize" the C-terminal portion of p105, I kappa B gamma, which is degraded during p105 processing to mature p50.@(((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "VB") (:stem . "\\"stabilize") (:form . "\\"stabilize") (:end . 100)\n  (:start . 90) (:id . 59))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 116)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 135) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 141)\n  (:start . 136) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 149)\n  (:start . 144) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 156)\n  (:start . 151) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 168)\n  (:start . 160) (:id . 74))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 175)\n  (:start . 169) (:id . 75))\n ((:tag . "NN") (:stem . "p105") (:form . "p105") (:end . 180) (:start . 176)\n  (:id . 76))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 191)\n  (:start . 181) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 201)\n  (:start . 195) (:id . 79))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 205) (:start . 202)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1074.6.1) (:span 4 11 78 81)))\n (:nscopes ((:id . :x1074.6.1) (:span 4 205)))\n (:identifiers (:sid . :s1074.6) (:did . :|9247567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010033@unknown@formal@none@1@S@These results indicate that CsA interferes with a specific event in the signal-induced degradation of I kappa B alpha and I kappa B beta, but does not affect the processing of NF-kappa B1/p105 to p50.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "signal-induced") (:form . "signal-induced")\n  (:end . 86) (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 98)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 157)\n  (:start . 151) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 71))\n ((:tag . "NN") (:stem . "processing") (:form . "processing") (:end . 172)\n  (:start . 162) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 184)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "b1/p105") (:form . "B1/p105") (:end . 192)\n  (:start . 185) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 195) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 199) (:start . 196)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1074.7.2) (:span 14 27)))\n (:ncues ((:id . :x1074.7.1) (:span 147 150)))\n (:hscopes ((:id . :x1074.7.2) (:span 14 199)))\n (:nscopes ((:id . :x1074.7.1) (:span 147 199)))\n (:identifiers (:sid . :s1074.7) (:did . :|9247567|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010034@unknown@formal@none@1@S@EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes.@(((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "collaborate") (:form . "collaborate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 77) (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1075.1) (:did . :|9252117|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010035@unknown@formal@none@1@S@Early B cell factor (EBF) and E47 participate in the transcriptional control of early B lymphocyte differentiation.@(((:tag . "JJ") (:stem . "early") (:form . "Early") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "participate") (:form . "participate") (:end . 45)\n  (:start . 34) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 68) (:start . 53) (:id . 54))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 114) (:start . 99) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1075.2) (:did . :|9252117|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010036@unknown@formal@none@1@S@With the aim of identifying genetic targets for these transcription factors, we stably transfected cDNAs encoding EBF or a covalent homodimer of E47, individually or together, into immature hematopoietic Ba/F3 cells, which lack both factors.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "transfecte") (:form . "transfected") (:end . 98)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "covalent") (:form . "covalent") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 141)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "RB") (:stem . "individually") (:form . "individually") (:end . 162)\n  (:start . 150) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 70))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 189)\n  (:start . 181) (:id . 72))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 203) (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "ba/f3") (:form . "Ba/F3") (:end . 209)\n  (:start . 204) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 222)\n  (:start . 217) (:id . 77))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 227) (:start . 223)\n  (:id . 78))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 240)\n  (:start . 233) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1075.3.1) (:span 223 227)))\n (:nscopes ((:id . :x1075.3.1) (:span 223 240)))\n (:identifiers (:sid . :s1075.3) (:did . :|9252117|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010037@unknown@formal@none@1@S@In combination, EBF and E47 induce efficient expression of the endogenous immunoglobulin surrogate light chain genes, lambda5 and VpreB, whereas other pre-B cell-specific genes remain silent.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lambda5") (:form . "lambda5") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "VpreB") (:form . "VpreB") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 170) (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 176)\n  (:start . 171) (:id . 68))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 183)\n  (:start . 177) (:id . 69))\n ((:tag . "JJ") (:stem . "silent") (:form . "silent") (:end . 190)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1075.4) (:did . :|9252117|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010038@unknown@formal@none@1@S@Multiple functionally important EBF and E47 binding sites were identified in the lambda5 promoter/enhancer region, indicating that lambda5 is a direct genetic target for these transcription factors.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 31)\n  (:start . 22) (:id . 44))\n ((:tag . "NNP") (:stem . "EBF") (:form . "EBF") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lambda5") (:form . "lambda5") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "promoter/enhancer") (:form . "promoter/enhancer")\n  (:end . 106) (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 113)\n  (:start . 107) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lambda5") (:form . "lambda5") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 165)\n  (:start . 159) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 175)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 189) (:start . 176) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 197)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1075.5.1) (:span 115 130)))\n (:hscopes ((:id . :x1075.5.1) (:span 115 197)))\n (:identifiers (:sid . :s1075.5) (:did . :|9252117|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010040@unknown@formal@none@1@S@Nuclear levels of NF-kappaB correlate with syncytium-forming capacity of 8e51 cells, expressing a defective HIV virus.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "correlate") (:form . "correlate") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "syncytium-forming") (:form . "syncytium-forming")\n  (:end . 60) (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "8e51") (:form . "8e51") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1076.1) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010041@unknown@formal@none@1@S@The double NF-kappaB site identified in the LTR of the human immunodeficiency virus-1 (HIV-1) has been demonstrated to be necessary for efficient viral transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 77) (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "virus-1") (:form . "virus-1") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 115)\n  (:start . 103) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 165) (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1076.2) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010042@unknown@formal@none@1@S@In this report we present the characterisation of NF-kappaB subunits engaged in complexes binding to the HIV-1 NF-kappaB site in human 8e51 T-cells, that harbour a defective HIV-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "characterisation") (:form . "characterisation")\n  (:end . 46) (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "VBN") (:stem . "engage") (:form . "engaged") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "8e51") (:form . "8e51") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "t-cell") (:form . "T-cells") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "harbour") (:form . "harbour") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 173)\n  (:start . 164) (:id . 69))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1076.3) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010043@unknown@formal@none@1@S@At least four different specific NF-kappaB complexes are present in the nucleus of these cells.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1076.4) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010044@unknown@formal@none@1@S@With the use of specific antibodies we have determined the composition of each complex using electrophoretic mobility shift assays.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 108) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1076.5) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010045@unknown@formal@none@1@S@The results show the presence of several NF-kappaB family members, with the transactivating RelA being engaged in multiple complexes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "transactivate") (:form . "transactivating")\n  (:end . 91) (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "rela") (:form . "RelA") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "engage") (:form . "engaged") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1076.6) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010046@unknown@formal@none@1@S@The importance of NF-kappaB complexes in viral functions has been established comparing the level of NF-kappaB DNA-binding complexes with syncytia-forming activity of 8e51 cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 122)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 132)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "syncytia-forming") (:form . "syncytia-forming")\n  (:end . 154) (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 163)\n  (:start . 155) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 63))\n ((:tag . "NN") (:stem . "8e51") (:form . "8e51") (:end . 171) (:start . 167)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 177)\n  (:start . 172) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1076.7) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010047@unknown@formal@none@1@S@In fact, 8e51 cells that had almost lost their syncytia-forming capacity were found to contain at least 10 times less active NF-kappaB DNA-binding complex than the actively fusing cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "8e51") (:form . "8e51") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 46)\n  (:start . 41) (:id . 51))\n ((:tag . "JJ") (:stem . "syncytia-forming") (:form . "syncytia-forming")\n  (:end . 63) (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 103)\n  (:start . 98) (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 146)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "VBG") (:stem . "fuse") (:form . "fusing") (:end . 179)\n  (:start . 173) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1076.8) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010048@unknown@formal@none@1@S@The correlation is specific as the level of at least three other transcription factors did not change.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "change") (:form . "change") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1076.9.1) (:span 91 94)))\n (:nscopes ((:id . :x1076.9.1) (:span 91 101)))\n (:identifiers (:sid . :s1076.9) (:did . :|9256234|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010050@unknown@formal@none@1@S@The leukocyte-specific, cytoskeleton-binding pp52 (LSP-1, WP-34) protein is widely expressed in multiple leukocyte lineages, including B and T lymphocytes, granulocytes, and macrophages.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "leukocyte-specific") (:form . "leukocyte-specific")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytoskeleton-binding")\n  (:form . "cytoskeleton-binding") (:end . 44) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "pp52") (:form . "pp52") (:end . 49) (:start . 45)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LSP-1") (:form . "LSP-1") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "WP-34") (:form . "WP-34") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "lineage") (:form . "lineages") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 168)\n  (:start . 156) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 185)\n  (:start . 174) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1077.2) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010051@unknown@formal@none@1@S@We previously detected a tissue-specific promoter preceding the exon encoding the N terminus of the pp52 leukocyte protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tissue-specific") (:form . "tissue-specific")\n  (:end . 40) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "VBG") (:stem . "precede") (:form . "preceding") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pp52") (:form . "pp52") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1077.3) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010052@unknown@formal@none@1@S@Here we describe the functional characterization of this promoter and identification of the factors in B and T cells that regulate its activity.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 48) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 84) (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1077.4) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010053@unknown@formal@none@1@S@The pp52 promoter contains an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a lone C/EBP motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pp52") (:form . "pp52") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "initiator") (:form . "initiator") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBG") (:stem . "specify") (:form . "specifying") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pp52") (:form . "pp52") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ets") (:form . "Ets") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 122)\n  (:start . 116) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "lone") (:form . "lone") (:end . 134) (:start . 130)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 140)\n  (:start . 135) (:id . 69))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 146)\n  (:start . 141) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1077.5) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010054@unknown@formal@none@1@S@All these motifs are essential and collectively control transcriptional activity.@(((:tag . "PDT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "collectively") (:form . "collectively") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 71) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1077.6) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010055@unknown@formal@none@1@S@DNA binding studies and Ab supershift assays revealed that different combinations of factors interact with these motifs in B cells vs T cells.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 81)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "vs") (:form . "vs") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1077.7) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010056@unknown@formal@none@1@S@The Ets motifs are preferentially bound by PU-1 in B cell extracts from all stages of development, whereas a different Ets family member reacts with these motifs in T cell extracts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 33) (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pu-1") (:form . "PU-1") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "NNP") (:stem . "Ets") (:form . "Ets") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 129)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "VBZ") (:stem . "react") (:form . "reacts") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 161)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 180)\n  (:start . 172) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1077.8) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010057@unknown@formal@none@1@S@The C/EBP motif is bound by Ig/EBP-1 in pre-B cell and T cell extracts, but is replaced by nuclear factor-IL-6beta or a nuclear factor-IL-6beta-Ig/EBP-1 heterodimer in plasmacytoma cell extracts.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ig/ebp-1") (:form . "Ig/EBP-1") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 87)\n  (:start . 79) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 61))\n ((:tag . "NN") (:stem . "factor-il-6beta") (:form . "factor-IL-6beta")\n  (:end . 114) (:start . 99) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 127)\n  (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "factor-il-6beta-ig/ebp-1")\n  (:form . "factor-IL-6beta-Ig/EBP-1") (:end . 152) (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 164)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "plasmacytoma") (:form . "plasmacytoma") (:end . 180)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 194)\n  (:start . 186) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1077.9) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010058@unknown@formal@none@1@S@Despite its reported role as a negative regulator of transcription, Ig/EBP-1 appears to exert a stimulatory effect on this promoter.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ig/ebp-1") (:form . "Ig/EBP-1") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1077.10.1) (:span 77 84)))\n (:hscopes ((:id . :x1077.10.1) (:span 68 131)))\n (:identifiers (:sid . :s1077.10) (:did . :|9257843|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010060@unknown@formal@none@1@S@Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 45) (:start . 31) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "th2-specific") (:form . "Th2-specific") (:end . 109)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin-5") (:form . "interleukin-5")\n  (:end . 141) (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1078.1) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010061@unknown@formal@none@1@S@Interleukin-5 (IL-5), which is produced by CD4(+) T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma.@(((:tag . "NNP") (:stem . "Interleukin-5") (:form . "Interleukin-5")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 65) (:start . 62)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 77) (:start . 74)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 62))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 88) (:start . 85)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 101) (:start . 96)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 107) (:start . 104)\n  (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 112) (:start . 108)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 71))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 131)\n  (:start . 120) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 73))\n ((:tag . "NN") (:stem . "eosinophilia") (:form . "eosinophilia") (:end . 147)\n  (:start . 135) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 75))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 157)\n  (:start . 151) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x1078.2.1) (:span 78 81)))\n (:nscopes ((:id . :x1078.2.1) (:span 78 94)))\n (:identifiers (:sid . :s1078.2) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010062@unknown@formal@none@1@S@Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+) T helper cells, Th1 and Th2, the molecular basis for Th1- and Th2- specific gene expression remains to be elucidated.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "outcome") (:form . "outcome") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Th1") (:form . "Th1") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Th2") (:form . "Th2") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 160)\n  (:start . 151) (:id . 71))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 166)\n  (:start . 161) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 170) (:start . 167)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Th1-") (:form . "Th1-") (:end . 175) (:start . 171)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 75))\n ((:tag . "NN") (:stem . "th2-") (:form . "Th2-") (:end . 184) (:start . 180)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 193)\n  (:start . 185) (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 198) (:start . 194)\n  (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 209)\n  (:start . 199) (:id . 79))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 217)\n  (:start . 210) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 220) (:start . 218)\n  (:id . 81))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 223) (:start . 221)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 234)\n  (:start . 224) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1078.3.1) (:span 210 234)))\n (:hscopes ((:id . :x1078.3.1) (:span 147 234)))\n (:identifiers (:sid . :s1078.3) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010063@unknown@formal@none@1@S@We previously established a critical role for the transcription factor GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "establish") (:form . "established") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "th1-") (:form . "Th1-") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "th2-type") (:form . "Th2-type") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1078.4) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010064@unknown@formal@none@1@S@Our studies reported here demonstrate that GATA-3 is critical for expression of the IL-5 gene in bona fide Th2 cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "FW") (:stem . "bona") (:form . "bona") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "FW") (:stem . "fide") (:form . "fide") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1078.5) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010065@unknown@formal@none@1@S@Whereas mutations in the GATA-3 site abolished antigen- or cAMP- stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "antigen-") (:form . "antigen-") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "camp-") (:form . "cAMP-") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gata-3") (:form . "GATA-3") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "non-lymphoid") (:form . "non-lymphoid") (:end . 177)\n  (:start . 165) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "non-il-5-producing") (:form . "non-IL-5-producing")\n  (:end . 197) (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 202) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 217)\n  (:start . 208) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 226) (:start . 222)\n  (:id . 77))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 235)\n  (:start . 227) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1078.6) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010066@unknown@formal@none@1@S@During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 26) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "CD4(+)") (:form . "CD4(+)") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . 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5010067@unknown@formal@none@1@S@Thus, GATA-3 may play an important role in the balance between Th1 and Th2 subsets in immune responses.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 12)\n  (:start . 6) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "balance") (:form . "balance") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 102)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1078.8.1) (:span 13 16)))\n (:hscopes ((:id . :x1078.8.1) (:span 13 102)))\n (:identifiers (:sid . :s1078.8) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010068@unknown@formal@none@1@S@Inhibition of GATA-3 activity has therapeutic potential in the treatment of asthma and other hypereosinophilic diseases.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GATA-3") (:form . "GATA-3") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hypereosinophilic") (:form . "hypereosinophilic")\n  (:end . 110) (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1078.9) (:did . :|9261181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010070@unknown@formal@none@1@S@Human immunodeficiency virus type 1 (HIV-1) Tat, an early regulatory protein that is critical for viral gene expression and replication, transactivates the HIV-1 long terminal repeat (LTR) via its binding to the transactivation response element (TAR) and, along with other cellular factors, increases viral transcription initiation and elongation.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . 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"long") (:form . "long") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 175)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 182)\n  (:start . 176) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 196) (:start . 193)\n  (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 204)\n  (:start . 197) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . 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5010071@unknown@formal@none@1@S@Tat also superactivates the HIV-1 promoter through a TAR-independent mechanism, including tumor necrosis factor alpha-induced and protein kinase C (PKC)-dependent activation of NF-kappa B, and inhibitors of Tat and NF-kappa B cooperatively down-regulate this Tat-mediated LTR superactivation.@(((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "superactivate") (:form . "superactivates")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "tar-independent") (:form . "TAR-independent")\n  (:end . 68) (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 89)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . "JJ") (:stem . "alpha-induced") (:form . "alpha-induced")\n  (:end . 125) (:start . 112) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 137)\n  (:start . 130) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 144)\n  (:start . 138) (:id . 60))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 146) (:start . 145)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PKC)-dependent") (:form . "PKC)-dependent")\n  (:end . 162) (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 185)\n  (:start . 177) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 187) (:start . 186)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 203)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 210) (:start . 207)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 223)\n  (:start . 215) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 225) (:start . 224)\n  (:id . 75))\n ((:tag . "RB") (:stem . "cooperatively") (:form . "cooperatively")\n  (:end . 239) (:start . 226) (:id . 76))\n ((:tag . "VBP") (:stem . "down-regulate") (:form . "down-regulate")\n  (:end . 253) (:start . 240) (:id . 77))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 258) (:start . 254)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "tat-mediated") (:form . "Tat-mediated") (:end . 271)\n  (:start . 259) (:id . 79))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 275) (:start . 272)\n  (:id . 80))\n ((:tag . "NN") (:stem . "superactivation") (:form . "superactivation")\n  (:end . 291) (:start . 276) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1079.3) (:did . :|9261367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010072@unknown@formal@none@1@S@In this study, a combined pharmacologic and genetic strategy using two PKC (NF-kappa B) inhibitors, pentoxifylline (PTX) and Go-6976, and a stably expressed anti-Tat single-chain intracellular antibody (sFv intrabody) was employed to obtain cooperative inhibition of both HIV-1 LTR-driven gene expression and HIV-1 replication.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 25)\n  (:start . 17) (:id . 47))\n ((:tag . "JJ") (:stem . "pharmacologic") (:form . 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5010073@unknown@formal@none@1@S@Treatment of cells with PTX and Go-6976 resulted in cooperative inhibition of both HIV-1 LTR-driven gene expression and HIV-1 replication.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PTX") (:form . "PTX") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Go-6976") (:form . "Go-6976") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ltr-driven") (:form . "LTR-driven") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 137)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1079.5) (:did . :|9261367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010074@unknown@formal@none@1@S@In addition, the combined use of anti-Tat sFv intrabodies and the two NF-kappa B inhibitors retained the virus in the latent state for as long as 45 days.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-tat") (:form . "anti-Tat") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "sfv") (:form . "sFv") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "intrabody") (:form . "intrabodies") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "VBD") (:stem . "retain") (:form . "retained") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 142) (:start . 138)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 68))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 148) (:start . 146)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 153) (:start . 149)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1079.6) (:did . :|9261367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010075@unknown@formal@none@1@S@The combined treatment resulted in more durable inhibition of HIV-1 replication than was seen with the NF-kappa B inhibitors alone or the anti-Tat sFv intrabodies alone.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "durable") (:form . "durable") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "anti-tat") (:form . "anti-Tat") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "sfv") (:form . "sFv") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "intrabody") (:form . "intrabodies") (:end . 162)\n  (:start . 151) (:id . 66))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 168)\n  (:start . 163) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1079.7) (:did . :|9261367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010076@unknown@formal@none@1@S@Together, these results suggest that in future clinical gene therapy trials, a combined pharmacologic and genetic strategy like the one reported here may improve the survival of transduced cells and prolong clinical benefit.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "trial") (:form . "trials") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "pharmacologic") (:form . "pharmacologic")\n  (:end . 101) (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "VB") (:stem . "improve") (:form . "improve") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 188)\n  (:start . 178) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "VB") (:stem . "prolong") (:form . "prolong") (:end . 206)\n  (:start . 199) (:id . 74))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 215)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "benefit") (:form . "benefit") (:end . 223)\n  (:start . 216) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1079.8.1) (:span 150 153))\n  ((:id . :x1079.8.2) (:span 24 31)))\n (:hscopes ((:id . :x1079.8.1) (:span 150 223))\n  ((:id . :x1079.8.2) (:span 24 223)))\n (:identifiers (:sid . :s1079.8) (:did . :|9261367|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010077@unknown@formal@none@1@S@Transcription factors in immune-mediated disease.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "immune-mediated") (:form . "immune-mediated")\n  (:end . 40) (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 48)\n  (:start . 41) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s1080.1) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010078@unknown@formal@none@1@S@A large amount of detailed information about the intracellular proteins regulating NF-kappa B activation and the cellular response to NF-kappa B activation has emerged recently.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 167)\n  (:start . 160) (:id . 65))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 176)\n  (:start . 168) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1080.2) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010080@unknown@formal@none@1@S@Despite this, there are still significant gaps in our understanding of this process and its consequences.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "gap") (:form . "gaps") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 67) (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 104)\n  (:start . 92) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1080.4) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010081@unknown@formal@none@1@S@In contrast, the characterization of transcription factors selectively regulating cytokine production by CD4+ T cell subsets is at a very early stage.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 33) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 70)\n  (:start . 59) (:id . 50))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 81)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 109) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 111) (:start . 110)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1080.5) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010082@unknown@formal@none@1@S@Three interacting proteins have recently been shown to contribute to subset-restricted expression of the IL-4 gene.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "subset-restricted") (:form . "subset-restricted")\n  (:end . 86) (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1080.6) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010083@unknown@formal@none@1@S@There are other elements regulating IL-4 gene expression, however, and the relative importance of these recently identified proteins has yet to be determined.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 123)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 157)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1080.7) (:did . :|9265727|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010084@unknown@formal@none@1@S@CholecystokininB receptor from human Jurkat lymphoblastic T cells is involved in activator protein-1-responsive gene activation.@(((:tag . "NNP") (:stem . "CholecystokininB") (:form . "CholecystokininB")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 25)\n  (:start . 17) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 90)\n  (:start . 81) (:id . 53))\n ((:tag . "JJ") (:stem . "protein-1-responsive")\n  (:form . "protein-1-responsive") (:end . 111) (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 116) (:start . 112)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1081.1) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010085@unknown@formal@none@1@S@The aim of this study was to analyze the role of cholecystokinin (CCK(B)) receptor in human lymphoblastic Jurkat T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cholecystokinin") (:form . "cholecystokinin")\n  (:end . 64) (:start . 49) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "CCK(B))") (:form . "CCK(B))") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 105) (:start . 92) (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1081.2) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010086@unknown@formal@none@1@S@We investigated the trophic effect resulting from activation of such a receptor by using the reporter gene strategy.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "trophic") (:form . "trophic") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1081.3) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010087@unknown@formal@none@1@S@For this purpose, we transiently transfected Jurkat T cells with the reporter plasmid p[(TRE)3-tk-Luc] and found that CCK-8 was able to dose-dependently induce luciferase expression related to activator protein-1 (AP-1) activation with a maximal response identical to that obtained with compounds known to activate AP-1 complex (quantitatively, the same level of induction was obtained with 1 nM 12-O-tetradecanoylphorbol-13-acetate, 100 microM diacylglycerol, or 4 nM epidermal growth factor).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . 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")") (:end . 493) (:start . 492)\n  (:id . 117))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 494) (:start . 493)\n  (:id . 118)))@@@1@77@((:identifiers (:sid . :s1081.4) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010088@unknown@formal@none@1@S@The involvement of the CCK(B) receptor in such a stimulation was demonstrated by the inhibiting effect of the selective CCK(B) receptor antagonist PD-135,158.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "CCK(B)") (:form . "CCK(B)") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 77)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "CCK(B)") (:form . "CCK(B)") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "PD-135,158") (:form . "PD-135,158") (:end . 157)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1081.5) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010090@unknown@formal@none@1@S@To better understand the AP-1-dependent luciferase expression in Jurkat T cells, we tested two specific inhibitors of serine/threonine phosphatases-1 and -2A: okadaic acid and calyculin A.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ap-1-dependent") (:form . "AP-1-dependent")\n  (:end . 39) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 71)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 90) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 134) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "phosphatases-1") (:form . "phosphatases-1")\n  (:end . 149) (:start . 135) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "-2a") (:form . "-2A") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 166)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 171) (:start . 167)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "calyculin") (:form . "calyculin") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1081.7) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010091@unknown@formal@none@1@S@These compounds strongly increased the phorbol-12-myristate-13-acetate response, whereas we have not observed a contribution of phosphatase inhibitors on a CCK-8-induced luciferase activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phorbol-12-myristate-13-acetate")\n  (:form . "phorbol-12-myristate-13-acetate") (:end . 70) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 79)\n  (:start . 71) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 88)\n  (:start . 81) (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 91) (:start . 89)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 96) (:start . 92)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 109)\n  (:start . 101) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 124)\n  (:start . 112) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 57))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 139)\n  (:start . 128) (:id . 58))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 150)\n  (:start . 140) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cck-8-induced") (:form . "CCK-8-induced")\n  (:end . 169) (:start . 156) (:id . 62))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 180)\n  (:start . 170) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 189)\n  (:start . 181) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1081.8.1) (:span 97 100)))\n (:nscopes ((:id . :x1081.8.1) (:span 97 189)))\n (:identifiers (:sid . :s1081.8) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010092@unknown@formal@none@1@S@To confirm that CCK(B) receptors are involved in AP-1 response, we investigated the CCK-8 effect on interleukin-2 expression, a natural endogenous gene regulated by several factors, including AP-1.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "CCK(B)") (:form . "CCK(B)") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 79)\n  (:start . 67) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cck-8") (:form . "CCK-8") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 113) (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 191)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1081.9) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010093@unknown@formal@none@1@S@In Jurkat T cells activated by phorbol-12-myristate-13-acetate and phytohemagglutinin, CCK-8 induced IL-2 expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phorbol-12-myristate-13-acetate")\n  (:form . "phorbol-12-myristate-13-acetate") (:end . 62) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "phytohemagglutinin") (:form . "phytohemagglutinin")\n  (:end . 85) (:start . 67) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cck-8") (:form . "CCK-8") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 100)\n  (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 105) (:start . 101)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1081.10) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010094@unknown@formal@none@1@S@This induction was abolished by PD-135,158.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "PD-135,158") (:form . "PD-135,158") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1081.11) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010095@unknown@formal@none@1@S@Our results indicate that CCK-8 exerts a trophic effect in Jurkat T cells through stimulation of CCK(B) receptors by modulation of expression of AP-1-regulated genes.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cck-8") (:form . "CCK-8") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "trophic") (:form . "trophic") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "CCK(B)") (:form . "CCK(B)") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "ap-1-regulated") (:form . "AP-1-regulated")\n  (:end . 159) (:start . 145) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1081.12.1) (:span 12 25)))\n (:hscopes ((:id . :x1081.12.1) (:span 12 165)))\n (:identifiers (:sid . :s1081.12) (:did . :|9271352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010096@unknown@formal@none@1@S@Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CD21") (:form . "CD21") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1082.1) (:did . :|9271588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010097@unknown@formal@none@1@S@Epstein-Barr virus (EBV), an oncogenic human herpesvirus, binds to and infects normal human B lymphocytes via CD21, the CR2 complement receptor.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "infect") (:form . "infects") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 105)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CD21") (:form . "CD21") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cr2") (:form . "CR2") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 134)\n  (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1082.2) (:did . :|9271588|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010098@unknown@formal@none@1@S@Studies of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-kappaB transcription factor, which, in turn, binds to and mediates transcriptional activation of Wp, the initial viral latent gene promoter.@(((:tag . "NNS") (:stem . "study") (:form . "Studies") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "enable") (:form . "enable") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . 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5010100@unknown@formal@none@1@S@Activation of transcription factor NF-kappa B by phagocytic stimuli in human neutrophils.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "phagocytic") (:form . "phagocytic") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 88)\n  (:start . 77) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1083.1) (:did . :|9276471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010101@unknown@formal@none@1@S@Phagocytosis represents an important physiological trigger for the inducible expression of several genes in human neutrophils.@(((:tag . "NNP") (:stem . "Phagocytosis") (:form . "Phagocytosis") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 50) (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "trigger") (:form . "trigger") (:end . 58)\n  (:start . 51) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 98)\n  (:start . 91) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 104) (:start . 99)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 125)\n  (:start . 114) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1083.2) (:did . :|9276471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010102@unknown@formal@none@1@S@Here, we report that a DNA-binding activity primarily consisting of the classical NF-kappa B heterodimer, p50/RelA, is induced in phagocytosing neutrophils.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 34)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "p50/RelA") (:form . "p50/RelA") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "phagocytose") (:form . "phagocytosing")\n  (:end . 143) (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 155)\n  (:start . 144) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1083.3) (:did . :|9276471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010103@unknown@formal@none@1@S@Under these conditions, NF-kappa B activation was found to be a rapid and transient response, reaching a maximum by 10-15 min, and returning to near-basal levels by 30 min.@(((:tag . "IN") (:stem . "under") (:form . "Under") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "reach") (:form . "reaching") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "CD") (:stem . "10-15") (:form . "10-15") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "return") (:form . "returning") (:end . 140)\n  (:start . 131) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "near-basal") (:form . "near-basal") (:end . 154)\n  (:start . 144) (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 161)\n  (:start . 155) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 171) (:start . 168)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1083.4) (:did . :|9276471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010104@unknown@formal@none@1@S@In neutrophils undergoing the phagocytosis of opsonized yeasts, the onset of NF-kappa B activation was paralleled by a decline in immunoreactive I kappa B-alpha protein levels, and the cellular I kappa B-alpha pool was replenished by 30 min, in agreement with our gel shift data.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phagocytosis") (:form . "phagocytosis") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "opsonize") (:form . 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5010105@unknown@formal@none@1@S@We conclude that NF-kappa B activation could constitute one of the mechanisms whereby the expression of kappa B-responsive genes is enhanced in phagocytosing neutrophils.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "constitute") (:form . "constitute") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "b-responsive") (:form . "B-responsive") (:end . 122)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "phagocytose") (:form . "phagocytosing")\n  (:end . 157) (:start . 144) (:id . 64))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 169)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1083.6.1) (:span 39 44)))\n (:hscopes ((:id . :x1083.6.1) (:span 39 169)))\n (:identifiers (:sid . :s1083.6) (:did . :|9276471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010106@unknown@formal@none@1@S@To our knowledge, this represents the first demonstration that phagocytic stimuli can induce NF-kappa B activation in human neutrophils.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "phagocytic") (:form . "phagocytic") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1083.7) (:did . :|9276471|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010107@unknown@formal@none@1@S@Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line.@(((:tag . "JJ") (:stem . "surfactant") (:form . "Surfactant") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1084.1) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010108@unknown@formal@none@1@S@The expression of many genes for which products are involved in inflammation is controlled by the transcriptional regulator nuclear factor (NF)-kappa B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 113) (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF)-kappa") (:form . "NF)-kappa") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1084.2) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010110@unknown@formal@none@1@S@We used gel shift assays to determine whether SP-A activated NF-kappa B in the THP-1 cell line, a human monocytic cell line.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "SP-A") (:form . "SP-A") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 103) (:start . 98)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 113)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1084.4.1) (:span 38 45)))\n (:hscopes ((:id . :x1084.4.1) (:span 38 123)))\n (:identifiers (:sid . :s1084.4) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010111@unknown@formal@none@1@S@Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml occurred within 30 min of SP-A treatment, peaked at 60 min, and then declined.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SP-A") (:form . "SP-A") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "microgram/ml") (:form . "microgram/ml") (:end . 78)\n  (:start . 66) (:id . 56))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SP-A") (:form . "SP-A") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 119)\n  (:start . 110) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "peak") (:form . "peaked") (:end . 127)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 133) (:start . 131)\n  (:id . 67))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 70))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 147) (:start . 143)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "decline") (:form . "declined") (:end . 156)\n  (:start . 148) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1084.5) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010112@unknown@formal@none@1@S@This activation is inhibited by known inhibitors of NF-kappa B or by simultaneous treatment of the cells with surfactant lipids.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 81)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "surfactant") (:form . "surfactant") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "lipid") (:form . "lipids") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1084.6.1) (:span 63 65)))\n (:hscopes ((:id . :x1084.6.1) (:span 29 127)))\n (:identifiers (:sid . :s1084.6) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010113@unknown@formal@none@1@S@Moreover, the NF-kappa B inhibitors blocked SP-A-dependent increases in tumor necrosis factor-alpha mRNA levels.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "sp-a-dependent") (:form . "SP-A-dependent")\n  (:end . 58) (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 99)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 111)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1084.7) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010114@unknown@formal@none@1@S@These observations suggest a mechanism by which SP-A plays a role in the pathogenesis of some lung conditions and point to potential therapeutic measures that could be used to prevent SP-A induced inflammation in the lung.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SP-A") (:form . "SP-A") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "point") (:form . "point") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 132)\n  (:start . 123) (:id . 63))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 144)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 66))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "SP-A") (:form . "SP-A") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "induced") (:form . "induced") (:end . 196)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 209)\n  (:start . 197) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 221) (:start . 217)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1084.8.1) (:span 159 164))\n  ((:id . :x1084.8.2) (:span 123 132)) ((:id . :x1084.8.3) (:span 19 26)))\n (:hscopes ((:id . :x1084.8.1) (:span 154 221))\n  ((:id . :x1084.8.2) (:span 123 221)) ((:id . :x1084.8.3) (:span 19 221)))\n (:identifiers (:sid . :s1084.8) (:did . :|9277450|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010115@unknown@formal@none@1@S@alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization.@(((:tag . "NN") (:stem . "alpha-tocopheryl") (:form . "alpha-Tocopheryl")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 35)\n  (:start . 27) (:id . 44))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 45)\n  (:start . 36) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 59)\n  (:start . 51) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 74)\n  (:start . 63) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "suppress") (:form . "suppressing") (:end . 95)\n  (:start . 84) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 104)\n  (:start . 96) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mobilization") (:form . "mobilization") (:end . 119)\n  (:start . 107) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1085.1) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010116@unknown@formal@none@1@S@The adherence of monocytes to activated endothelium is an early event in atherogenesis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1085.2) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010117@unknown@formal@none@1@S@Because antioxidants have been considered to be of antiatherosclerotic potential, we investigated the effects of alpha-tocopherol (TCP) and its acetate and succinate esters on monocyte adhesion to cytokine-stimulated human umbilical vein endothelial cells (HUVEC).@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antiatherosclerotic")\n  (:form . "antiatherosclerotic") (:end . 70) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 97)\n  (:start . 85) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . "alpha-tocopherol")\n  (:end . 129) (:start . 113) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 165)\n  (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 172)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 193)\n  (:start . 185) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cytokine-stimulated")\n  (:form . "cytokine-stimulated") (:end . 216) (:start . 197) (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 222)\n  (:start . 217) (:id . 73))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 232)\n  (:start . 223) (:id . 74))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 237) (:start . 233)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 249)\n  (:start . 238) (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 255)\n  (:start . 250) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 257) (:start . 256)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 262)\n  (:start . 257) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 263) (:start . 262)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1085.3) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010118@unknown@formal@none@1@S@Endothelial cells were treated with TCP, alpha-tocopherol acetate (TCP acetate), or alpha-tocopheryl succinate (TCP succinate) before stimulation with tumor necrosis factor-alpha (TNF-alpha; 10 U/ml, 6 h) or interleukin-1 beta (IL-1 beta; 10 U/ml, 6 h).@(((:tag . "JJ") (:stem . "endothelial") (:form . "Endothelial") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha-tocopherol") (:form . 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"(") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 189)\n  (:start . 180) (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 198) (:start . 194)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 201) (:start . 200)\n  (:id . 75))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 203) (:start . 202)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 207) (:start . 205)\n  (:id . 78))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 221) (:start . 208) (:id . 79))\n ((:tag . 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5010120@unknown@formal@none@1@S@TCP succinate (200 microM, 24 h) reduced TNF-induced VCAM-1 and E-selectin expression from a specific mean fluorescence intensity of 151 ± 28 to 12 ± 4 channels and from 225 ± 38 to 79 ± 21 channels, respectively.@(((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "200") (:form . "200") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 40)\n  (:start . 33) (:id . 51))\n ((:tag . "JJ") (:stem . "tnf-induced") (:form . "TNF-induced") (:end . 52)\n  (:start . 41) (:id . 52))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 119)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "intensity") (:form . "intensity") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "CD") (:stem . "151") (:form . "151") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "±") (:form . "±") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . ".") (:stem . "±") (:form . "±") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 151) (:start . 150)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 160)\n  (:start . 152) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 169) (:start . 165)\n  (:id . 73))\n ((:tag . "CD") (:stem . "225") (:form . "225") (:end . 173) (:start . 170)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "±") (:form . "±") (:end . 175) (:start . 174)\n  (:id . 75))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 178) (:start . 176)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 77))\n ((:tag . "CD") (:stem . "79") (:form . "79") (:end . 184) (:start . 182)\n  (:id . 78))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 186) (:start . 185)\n  (:id . 79))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 189) (:start . 187)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 198)\n  (:start . 190) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 82))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 212)\n  (:start . 200) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1085.6) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010121@unknown@formal@none@1@S@Succinate alone had no effect.@(((:tag . "NNP") (:stem . "Succinate") (:form . "Succinate") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 47)))@@@1@6@((:ncues ((:id . :x1085.7.1) (:span 20 22)))\n (:nscopes ((:id . :x1085.7.1) (:span 20 29)))\n (:identifiers (:sid . :s1085.7) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010122@unknown@formal@none@1@S@Decreased adhesion molecule expression was associated with a reduction of monocytic cell adhesion.@(((:tag . "VBN") (:stem . "decrease") (:form . "Decreased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1085.8) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010123@unknown@formal@none@1@S@TCP succinate (20 microM, 72 h), but not TCP (200 microM, 72 h), reduced U-937 cell adhesion to TNF-alpha-stimulated (10 U/ml, 6 h) HUVEC by 30% (P < 0.025) and to IL-1 beta-stimulated HUVEC by 56% (P < 0.010).@(((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . 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"(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 93))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 200) (:start . 199)\n  (:id . 94))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 202) (:start . 201)\n  (:id . 95))\n ((:tag . "CD") (:stem . "0.010") (:form . "0.010") (:end . 208)\n  (:start . 203) (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 98)))@@@1@57@((:ncues ((:id . :x1085.9.1) (:span 37 40)))\n (:nscopes ((:id . :x1085.9.1) (:span 37 63)))\n (:identifiers (:sid . :s1085.9) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010124@unknown@formal@none@1@S@Electrophoretic mobility-shift assays of HUVEC nuclear proteins revealed a decrease in TNF-alpha-stimulated nuclear factor-kappa B (NF-kappa B) activation after pretreatment of HUVEC with TCP succinate but not with TCP, TCP acetate, or succinate alone.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mobility-shift") (:form . "mobility-shift")\n  (:end . 30) (:start . 16) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 63)\n  (:start . 55) (:id . 48))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 72)\n  (:start . 64) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tnf-alpha-stimulated")\n  (:form . "TNF-alpha-stimulated") (:end . 107) (:start . 87) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 54))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 128)\n  (:start . 116) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 140)\n  (:start . 132) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 154)\n  (:start . 144) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 160)\n  (:start . 155) (:id . 62))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 173)\n  (:start . 161) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 182)\n  (:start . 177) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 187) (:start . 183)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 191) (:start . 188)\n  (:id . 67))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 201)\n  (:start . 192) (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 205) (:start . 202)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 214) (:start . 210)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 218) (:start . 215)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 223) (:start . 220)\n  (:id . 74))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 231)\n  (:start . 224) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 232) (:start . 231)\n  (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 235) (:start . 233)\n  (:id . 77))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 245)\n  (:start . 236) (:id . 78))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 251)\n  (:start . 246) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x1085.10.1) (:span 206 209)))\n (:nscopes ((:id . :x1085.10.1) (:span 206 251)))\n (:identifiers (:sid . :s1085.10) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010125@unknown@formal@none@1@S@In conclusion, we demonstrate that the vitamin E derivative TCP succinate prevents monocytic cell adhesion to cytokine-stimulated endothelial cells by inhibiting the activation of NF-kappa B, further emphasizing the antiatherosclerotic potential of lipid soluble antioxidants.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "derivative") (:form . "derivative") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "TCP") (:form . "TCP") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "succinate") (:form . "succinate") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cytokine-stimulated")\n  (:form . "cytokine-stimulated") (:end . 129) (:start . 110) (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 141)\n  (:start . 130) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 176)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 188)\n  (:start . 180) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 190) (:start . 189)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 69))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 199)\n  (:start . 192) (:id . 70))\n ((:tag . "VBG") (:stem . "emphasize") (:form . "emphasizing") (:end . 211)\n  (:start . 200) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "antiatherosclerotic")\n  (:form . "antiatherosclerotic") (:end . 235) (:start . 216) (:id . 73))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 245)\n  (:start . 236) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 75))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 254)\n  (:start . 249) (:id . 76))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 262)\n  (:start . 255) (:id . 77))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 275)\n  (:start . 263) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1085.11) (:did . :|9277478|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010126@unknown@formal@none@1@S@Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.@(((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "N-acetylcysteine") (:form . "N-acetylcysteine")\n  (:end . 40) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 51)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 71) (:start . 55) (:id . 48))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 82)\n  (:start . 72) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 93)\n  (:start . 87) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 104)\n  (:start . 94) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1086.1) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010127@unknown@formal@none@1@S@We have examined the effects of N-acetyl-L-cysteine (NAC), a well-characterized, thiol-containing antioxidant, on agonist-induced monocytic cell adhesion to endothelial cells (EC).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "N-acetyl-L-cysteine")\n  (:form . "N-acetyl-L-cysteine") (:end . 51) (:start . 32) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "well-characterized") (:form . "well-characterized")\n  (:end . 79) (:start . 61) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "thiol-containing") (:form . "thiol-containing")\n  (:end . 97) (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "agonist-induced") (:form . "agonist-induced")\n  (:end . 129) (:start . 114) (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 139)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 168)\n  (:start . 157) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1086.2) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010128@unknown@formal@none@1@S@NAC inhibited interleukin-1 (IL-1 beta)-induced, but not basal, adhesion with 50% inhibition at approximately 20 mM.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "beta)-induced") (:form . "beta)-induced")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 109) (:start . 96) (:id . 59))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mm") (:form . "mM") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1086.3.1) (:span 53 56)))\n (:nscopes ((:id . :x1086.3.1) (:span 53 62)))\n (:identifiers (:sid . :s1086.3) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010130@unknown@formal@none@1@S@Unlike published studies with pyrrolidinedithiocarbamate, which specifically inhibited vascular cell adhesion molecule 1 (VCAM-1), NAC inhibited IL-1 beta-induced mRNA and cell surface expression of both E-selectin and VCAM-1.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pyrrolidinedithiocarbamate")\n  (:form . "pyrrolidinedithiocarbamate") (:end . 56) (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 48))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 76)\n  (:start . 64) (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 86)\n  (:start . 77) (:id . 50))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 95)\n  (:start . 87) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 100) (:start . 96)\n  (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 109)\n  (:start . 101) (:id . 53))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 118)\n  (:start . 110) (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 120) (:start . 119)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 56))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 128)\n  (:start . 122) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 144)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 149) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "beta-induced") (:form . "beta-induced") (:end . 162)\n  (:start . 150) (:id . 63))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 167) (:start . 163)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 176) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 184)\n  (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 195)\n  (:start . 185) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 203) (:start . 199)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 214)\n  (:start . 204) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 218) (:start . 215)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 225)\n  (:start . 219) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1086.5) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010131@unknown@formal@none@1@S@NAC had no effect on the half-life of E-selectin or VCAM-1 mRNA.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x1086.6.1) (:span 8 10)))\n (:nscopes ((:id . :x1086.6.1) (:span 8 63)))\n (:identifiers (:sid . :s1086.6) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010132@unknown@formal@none@1@S@Although NAC reduced nuclear factor-kappa B (NF-kappa B) activation in EC as measured by gel-shift assays using an oligonucleotide probe corresponding to the consensus NF-kappa B binding sites of the VCAM-1 gene (VCAM-NF-kappa B), the antioxidant had no appreciable effect when an oligomer corresponding to the consensus NF-kappa B binding site of the E-selectin gene (E-selectin-NF-kappa B) was used.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . 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"an") (:end . 280) (:start . 278)\n  (:id . 88))\n ((:tag . "NN") (:stem . "oligomer") (:form . "oligomer") (:end . 289)\n  (:start . 281) (:id . 89))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 303)\n  (:start . 290) (:id . 90))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 306) (:start . 304)\n  (:id . 91))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 310) (:start . 307)\n  (:id . 92))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 320)\n  (:start . 311) (:id . 93))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 329)\n  (:start . 321) (:id . 94))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 331) (:start . 330)\n  (:id . 95))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 339)\n  (:start . 332) (:id . 96))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 344) (:start . 340)\n  (:id . 97))\n ((:tag . "IN") (:stem . "of") (:form . 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5010133@unknown@formal@none@1@S@Because NF-kappa B has been reported to be redox sensitive, we studied the effects of NAC on the EC redox environment.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 105)\n  (:start . 100) (:id . 62))\n ((:tag . "NN") (:stem . "environment") (:form . "environment") (:end . 117)\n  (:start . 106) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1086.8) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010134@unknown@formal@none@1@S@NAC caused an expected dramatic increase in the reduced glutathione (GSH) levels in EC.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "GSH") (:form . "GSH") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1086.9) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010135@unknown@formal@none@1@S@In vitro studies demonstrated that whereas the binding affinity of NF-kappa B to the VCAM-NF-kappa B oligomer peaked at a GSH-to-oxidized glutathione (GSSG) ratio of approximately 200 and decreased at higher ratios, the binding to the E-selectin-NF-kappa B oligomer appeared relatively unaffected even at ratios > 400, i.e., those achieved in EC treated with 40 mM NAC.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . 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"VBN") (:stem . "treat") (:form . "treated") (:end . 353)\n  (:start . 346) (:id . 99))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 358) (:start . 354)\n  (:id . 100))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 361) (:start . 359)\n  (:id . 101))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 364) (:start . 362)\n  (:id . 102))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 368) (:start . 365)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 369) (:start . 368)\n  (:id . 104)))@@@1@63@((:hcues ((:id . :x1086.10.1) (:span 266 274)))\n (:hscopes ((:id . :x1086.10.1) (:span 216 368)))\n (:identifiers (:sid . :s1086.10) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010136@unknown@formal@none@1@S@These results suggest that NF-kappa B binding to its consensus sequences in the VCAM-1 and E-selectin gene exhibits marked differences in redox sensitivity, allowing for differential gene expression regulated by the same transcription factor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "exhibit") (:form . "exhibits") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 155)\n  (:start . 144) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 169) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 182)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 187) (:start . 183)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 198)\n  (:start . 188) (:id . 70))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 208)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 211) (:start . 209)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 220) (:start . 216)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 234) (:start . 221) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 241)\n  (:start . 235) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1086.11.1) (:span 14 21)))\n (:hscopes ((:id . :x1086.11.1) (:span 14 241)))\n (:identifiers (:sid . :s1086.11) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010137@unknown@formal@none@1@S@Our data also demonstrate that NAC increases the GSH-to-GSSG ratio within the EC suggesting one possible mechanism through which this antioxidant inhibits agonist-induced monocyte adhesion to EC.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GSH-to-GSSG") (:form . "GSH-to-GSSG") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 145)\n  (:start . 134) (:id . 62))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 154)\n  (:start . 146) (:id . 63))\n ((:tag . "JJ") (:stem . "agonist-induced") (:form . "agonist-induced")\n  (:end . 170) (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 179)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 188)\n  (:start . 180) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 194) (:start . 192)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1086.12.1) (:span 96 104))\n  ((:id . :x1086.12.2) (:span 81 91)))\n (:hscopes ((:id . :x1086.12.1) (:span 96 194))\n  ((:id . :x1086.12.2) (:span 81 194)))\n (:identifiers (:sid . :s1086.12) (:did . :|9277499|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010138@unknown@formal@none@1@S@Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 64) (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 70) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 80)\n  (:start . 71) (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 87)\n  (:start . 81) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1087.1) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010140@unknown@formal@none@1@S@This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "integrin-mediated") (:form . "integrin-mediated")\n  (:end . 22) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 50)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 57)\n  (:start . 51) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "extravasation") (:form . "extravasation")\n  (:end . 75) (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 82)\n  (:start . 76) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 108)\n  (:start . 96) (:id . 54))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 118)\n  (:start . 109) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1087.3) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010141@unknown@formal@none@1@S@Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "integrin-ligand") (:form . "integrin-ligand")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "VBP") (:stem . "trigger") (:form . "trigger") (:end . 46)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 56)\n  (:start . 47) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 65)\n  (:start . 57) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 74) (:start . 71)\n  (:id . 50))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 84)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 104)\n  (:start . 95) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 117)\n  (:start . 109) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 126)\n  (:start . 121) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 142)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1087.4.1) (:span 71 74)))\n (:hscopes ((:id . :x1087.4.1) (:span 71 142)))\n (:identifiers (:sid . :s1087.4) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010142@unknown@formal@none@1@S@In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "combinatorial") (:form . "combinatorial")\n  (:end . 54) (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1087.5) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010143@unknown@formal@none@1@S@IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.@(((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "well-defined") (:form . "well-defined") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 53)\n  (:start . 41) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 113)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 141) (:start . 139)\n  (:id . 60))\n ((:tag . "NN") (:stem . "arginine-glycine-aspartate")\n  (:form . "arginine-glycine-aspartate") (:end . 168) (:start . 142)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "RGD)-coated") (:form . "RGD)-coated") (:end . 181)\n  (:start . 170) (:id . 63))\n ((:tag . "NNS") (:stem . "substrata") (:form . "substrata") (:end . 191)\n  (:start . 182) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 196) (:start . 193)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 205)\n  (:start . 197) (:id . 67))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 219) (:start . 206) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 228)\n  (:start . 223) (:id . 70))\n ((:tag . "JJ") (:stem . "matrix-adherent") (:form . "matrix-adherent")\n  (:end . 244) (:start . 229) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 250)\n  (:start . 245) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1087.6) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010144@unknown@formal@none@1@S@Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.@(((:tag . "VBN") (:stem . "compare") (:form . "Compared") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "suspension") (:form . "suspension") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "plastic") (:form . "plastic") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rgd") (:form . "RGD") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 121)\n  (:start . 112) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "threefold") (:form . "threefold") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 171)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 178)\n  (:start . 172) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "ifn-gamma-induced") (:form . "IFN-gamma-induced")\n  (:end . 199) (:start . 182) (:id . 70))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 204) (:start . 200)\n  (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 208) (:start . 205)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 217) (:start . 213)\n  (:id . 74))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 226)\n  (:start . 218) (:id . 75))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "gammaRI") (:form . "gammaRI") (:end . 237)\n  (:start . 230) (:id . 77))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 246)\n  (:start . 238) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1087.7) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010145@unknown@formal@none@1@S@By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5-") (:form . "5-") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "10-fold") (:form . "10-fold") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "stat1-containing") (:form . "STAT1-containing")\n  (:end . 132) (:start . 116) (:id . 62))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 144)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "gammaRI") (:form . "gammaRI") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1087.8) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010146@unknown@formal@none@1@S@Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "jak1") (:form . "JAK1") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "JAK2") (:form . "JAK2") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "rgd-adherent") (:form . "RGD-adherent") (:end . 132)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 142)\n  (:start . 133) (:id . 61))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 156) (:start . 152)\n  (:id . 63))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1087.9) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010147@unknown@formal@none@1@S@These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "integrin-mediated") (:form . "integrin-mediated")\n  (:end . 66) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 127) (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 147)\n  (:start . 135) (:id . 60))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 156)\n  (:start . 148) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 165)\n  (:start . 158) (:id . 63))\n ((:tag . "VBG") (:stem . "amplify") (:form . "amplifying") (:end . 176)\n  (:start . 166) (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 185)\n  (:start . 177) (:id . 65))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 192)\n  (:start . 186) (:id . 66))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 200)\n  (:start . 193) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 68))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 212)\n  (:start . 204) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 223)\n  (:start . 213) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 71))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 240)\n  (:start . 228) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1087.10.1) (:span 14 21)))\n (:hscopes ((:id . :x1087.10.1) (:span 14 240)))\n (:identifiers (:sid . :s1087.10) (:did . :|9278334|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010148@unknown@formal@none@1@S@The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor necrosis factor-alpha.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 33)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 40)\n  (:start . 34) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "JJ") (:stem . "low-density") (:form . "low-density") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 97)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 108)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 121)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 139)\n  (:start . 134) (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 148)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 161)\n  (:start . 149) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1088.1) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010150@unknown@formal@none@1@S@The integral membrane glycoprotein CD36 appears to play a physiological role in binding and uptake of Ox LDL by monocyte-macrophages, although the molecular events associated with CD36-Ox LDL interaction are unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "integral") (:form . "integral") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "cd36") (:form . "CD36") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Ox") (:form . "Ox") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophages") (:end . 132) (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 156)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "CD36-Ox") (:form . "CD36-Ox") (:end . 187)\n  (:start . 180) (:id . 69))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 203)\n  (:start . 192) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 207) (:start . 204)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 215)\n  (:start . 208) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1088.3.1) (:span 208 215))\n  ((:id . :x1088.3.2) (:span 40 47)))\n (:hscopes ((:id . :x1088.3.1) (:span 143 215))\n  ((:id . :x1088.3.2) (:span 0 132)))\n (:identifiers (:sid . :s1088.3) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010151@unknown@formal@none@1@S@To approach this issue, we used CD36 transfected Chinese hampster ovary (CHO) cells, exposed them to Ox LDL, and determined changes in the activity of the transcription factor NF-kappaB.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "approach") (:form . "approach") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 48)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "chinese") (:form . "Chinese") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "hampster") (:form . "hampster") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "ovary") (:form . "ovary") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CHO") (:form . "CHO") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "expose") (:form . "exposed") (:end . 92)\n  (:start . 85) (:id . 59))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ox") (:form . "Ox") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 123)\n  (:start . 113) (:id . 66))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 131)\n  (:start . 124) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 147)\n  (:start . 139) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 168) (:start . 155) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 175)\n  (:start . 169) (:id . 74))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 185)\n  (:start . 176) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1088.4) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010152@unknown@formal@none@1@S@We report here that Ox LDL enhanced DNA binding activity of nuclear extracts to an NF-kappaB sequence following activation of CD36-producing CHO cells with the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ox") (:form . "Ox") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cd36-producing") (:form . "CD36-producing")\n  (:end . 140) (:start . 126) (:id . 62))\n ((:tag . "NNP") (:stem . "CHO") (:form . "CHO") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 175) (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 184)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 190)\n  (:start . 185) (:id . 69))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 199)\n  (:start . 191) (:id . 70))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 212)\n  (:start . 200) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 214) (:start . 213)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 223)\n  (:start . 214) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1088.5) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010153@unknown@formal@none@1@S@This enhanced DNA binding activity was inhibited by coincubation of CD36 transfected cells with the human CD36-specific antibody OKM5.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "coincubation") (:form . "coincubation") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "cd36-specific") (:form . "CD36-specific")\n  (:end . 119) (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "okm5") (:form . "OKM5") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1088.6) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010154@unknown@formal@none@1@S@We also determined that activation of NF-kappaB DNA binding activity required an intact carboxyl-terminal cytoplasmic segment on CD36.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 105) (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 117)\n  (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1088.7) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010155@unknown@formal@none@1@S@Our results support the idea that human CD36 mediates signal transduction events in response to Ox LDL.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd36") (:form . "CD36") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ox") (:form . "Ox") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1088.8.1) (:span 24 28)))\n (:hscopes ((:id . :x1088.8.1) (:span 24 102)))\n (:identifiers (:sid . :s1088.8) (:did . :|9285527|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010156@unknown@formal@none@1@S@Transcriptional regulation during myelopoiesis.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 33)\n  (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 46)\n  (:start . 34) (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1089.1) (:did . :|9291089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010157@unknown@formal@none@1@S@The coordinated production of all blood cells from a common stem cell is a highly regulated process involving successive stages of commitment and differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "successive") (:form . "successive") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 161) (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1089.2) (:did . :|9291089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010158@unknown@formal@none@1@S@From analyses of mice deficient in transcription factor genes and from the characterizations of chromosome breakpoints in human leukemias, it has become evident that transcription factors are important regulators of hematopoiesis.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 48) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "characterization") (:form . "characterizations")\n  (:end . 92) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "breakpoint") (:form . "breakpoints") (:end . 118)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "leukemia") (:form . "leukemias") (:end . 137)\n  (:start . 128) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "become") (:form . "become") (:end . 152)\n  (:start . 146) (:id . 64))\n ((:tag . "JJ") (:stem . "evident") (:form . "evident") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 187)\n  (:start . 180) (:id . 68))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 191) (:start . 188)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 201)\n  (:start . 192) (:id . 70))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 212)\n  (:start . 202) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 72))\n ((:tag . "NN") (:stem . "hematopoiesis") (:form . "hematopoiesis")\n  (:end . 229) (:start . 216) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1089.3) (:did . :|9291089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010160@unknown@formal@none@1@S@Few of these factors are expressed exclusively in myeloid cells; instead it appears that they cooperatively regulate transcription of myeloid-specific genes.@(((:tag . "JJ") (:stem . "few") (:form . "Few") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "RB") (:stem . "cooperatively") (:form . "cooperatively")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "myeloid-specific") (:form . "myeloid-specific")\n  (:end . 150) (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 156)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1089.5.1) (:span 76 83)))\n (:hscopes ((:id . :x1089.5.1) (:span 76 156)))\n (:identifiers (:sid . :s1089.5) (:did . :|9291089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010161@unknown@formal@none@1@S@Here we discuss recent advances in transcriptional regulation during myelopoiesis.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "advance") (:form . "advances") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 50) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 81)\n  (:start . 69) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1089.6) (:did . :|9291089|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010162@unknown@formal@none@1@S@Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.@(((:tag . "JJ") (:stem . "genomic") (:form . "Genomic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "organization") (:form . "organization") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 51) (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "eotaxin") (:form . "eotaxin") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1090.1) (:did . :|9299399|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010163@unknown@formal@none@1@S@Eotaxin is an eosinophil specific beta-chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.@(((:tag . "NNP") (:stem . "Eotaxin") (:form . "Eotaxin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "beta-chemokine") (:form . "beta-chemokine")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 87)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 100)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "dermatitis") (:form . "dermatitis") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "rhinitis") (:form . "rhinitis") (:end . 154)\n  (:start . 146) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 162)\n  (:start . 156) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "parasitic") (:form . "parasitic") (:end . 176)\n  (:start . 167) (:id . 66))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 187)\n  (:start . 177) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1090.2) (:did . :|9299399|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010164@unknown@formal@none@1@S@Its expression is stimulus- and cell-specific.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stimulus-") (:form . "stimulus-") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1090.3) (:did . :|9299399|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010165@unknown@formal@none@1@S@We here describe the genomic organisation (3 exons of 132, 112 and 542 bp and 2 introns of 1211 and 378 bp) and sequence including 3 kb of DNA from the immediate 5' upstream region of the human eotaxin gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "organisation") (:form . "organisation") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "CD") (:stem . "132") (:form . "132") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "CD") (:stem . "112") (:form . "112") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "CD") (:stem . "542") (:form . "542") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 79) (:start . 78)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "intron") (:form . "introns") (:end . 87)\n  (:start . 80) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1211") (:form . "1211") (:end . 95) (:start . 91)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 63))\n ((:tag . "CD") (:stem . "378") (:form . "378") (:end . 103) (:start . 100)\n  (:id . 64))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 106) (:start . 104)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 120)\n  (:start . 112) (:id . 68))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 130)\n  (:start . 121) (:id . 69))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 132) (:start . 131)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 135) (:start . 133)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 72))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 142) (:start . 139)\n  (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 147) (:start . 143)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 161)\n  (:start . 152) (:id . 76))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 163) (:start . 162)\n  (:id . 77))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 164) (:start . 163)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 173)\n  (:start . 165) (:id . 79))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 180)\n  (:start . 174) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 193)\n  (:start . 188) (:id . 83))\n ((:tag . "NN") (:stem . "eotaxin") (:form . "eotaxin") (:end . 201)\n  (:start . 194) (:id . 84))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 206) (:start . 202)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1090.4) (:did . :|9299399|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010166@unknown@formal@none@1@S@Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "VBG") (:stem . 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5010167@unknown@formal@none@1@S@Rel/NF-kappa B transcription factors and the control of apoptosis.@(((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1091.1) (:did . :|9299589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010168@unknown@formal@none@1@S@The process of apoptosis is used to eliminate unwanted cells from a wide variety of organisms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "eliminate") (:form . "eliminate") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "unwanted") (:form . "unwanted") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1091.2) (:did . :|9299589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010170@unknown@formal@none@1@S@Recent work from several laboratories has demonstrated that Rel/NF-kappa B transcription factors regulate apoptosis in many cell types.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "laboratory") (:form . "laboratories") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 72)\n  (:start . 60) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 105)\n  (:start . 97) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 115)\n  (:start . 106) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 123) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 134)\n  (:start . 129) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1091.4) (:did . :|9299589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010171@unknown@formal@none@1@S@In most cells, Rel/NF-kappa B transcription factors appear to mediate survival signals that protect cells from apoptosis; however, under some circumstances, activation of these factors may also promote apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 27)\n  (:start . 15) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "protect") (:form . "protect") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 155) (:start . 142) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 167)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 193) (:start . 189)\n  (:id . 72))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 201)\n  (:start . 194) (:id . 73))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 211)\n  (:start . 202) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1091.5.1) (:span 185 188))\n  ((:id . :x1091.5.2) (:span 52 58)))\n (:hscopes ((:id . :x1091.5.1) (:span 185 211))\n  ((:id . :x1091.5.2) (:span 15 120)))\n (:identifiers (:sid . :s1091.5) (:did . :|9299589|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010172@unknown@formal@none@1@S@The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oncogenesis") (:form . "oncogenesis") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1092.1) (:did . :|9299590|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010173@unknown@formal@none@1@S@Rel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulatory mechanisms that involve protein-protein interactions, phosphorylation, ubiquitination, proteolytic degradation, and nucleocytoplasmic translocation.@(((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "subject") (:form . "subject") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 136)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 160)\n  (:start . 153) (:id . 64))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 176) (:start . 161) (:id . 65))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 189)\n  (:start . 177) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 206) (:start . 191) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 222) (:start . 208) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 235)\n  (:start . 224) (:id . 72))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 247)\n  (:start . 236) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 248) (:start . 247)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 252) (:start . 249)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "nucleocytoplasmic") (:form . "nucleocytoplasmic")\n  (:end . 270) (:start . 253) (:id . 76))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 284) (:start . 271) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 285) (:start . 284)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1092.2) (:did . :|9299590|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010174@unknown@formal@none@1@S@The sophisticated control of Rel/NF-kappa B activity is not surprising since this transcription factor is involved in a wide array of cellular responses to extracellular cues, associated with growth, development, apoptosis, and pathogen invasion.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "sophisticated") (:form . "sophisticated")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "surprising") (:form . "surprising") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "array") (:form . "array") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 169) (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "cue") (:form . "cues") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 186)\n  (:start . 176) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 198)\n  (:start . 192) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 72))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 211)\n  (:start . 200) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 74))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 222)\n  (:start . 213) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 77))\n ((:tag . "NN") (:stem . "pathogen") (:form . "pathogen") (:end . 236)\n  (:start . 228) (:id . 78))\n ((:tag . "NN") (:stem . "invasion") (:form . "invasion") (:end . 245)\n  (:start . 237) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x1092.3.1) (:span 56 59)))\n (:nscopes ((:id . :x1092.3.1) (:span 56 70)))\n (:identifiers (:sid . :s1092.3) (:did . :|9299590|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010175@unknown@formal@none@1@S@Thus, it is not unexpected that this versatile cellular homeostatic switch would be affected by a variety of viral pathogens, which have evolved mechanisms to utilize various aspects of Rel/NF-kappa B activity to facilitate their replication, cell survival and possibly evasion of immune responses.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unexpected") (:form . "unexpected") (:end . 26)\n  (:start . 16) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . 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5010176@unknown@formal@none@1@S@This review will cover the molecular mechanisms that are utilized by mammalian oncogenic viruses to affect the activity of Rel/NF-kappa B transcription factors and the role of Rel/NF-kappa B in the regulation of viral gene expression and replication.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "oncogenic") (:form . "oncogenic") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa")\n  (:end . 135) (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 151) (:start . 138) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Rel/NF-kappa") (:form . "Rel/NF-kappa")\n  (:end . 188) (:start . 176) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 190) (:start . 189)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 208)\n  (:start . 198) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 217)\n  (:start . 212) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 233)\n  (:start . 223) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 237) (:start . 234)\n  (:id . 78))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 249)\n  (:start . 238) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1092.5) (:did . :|9299590|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010177@unknown@formal@none@1@S@Abnormal apoptosis and cell cycle progression in humans exposed to methyl tertiary-butyl ether and benzene contaminating water.@(((:tag . "JJ") (:stem . "abnormal") (:form . "Abnormal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "methyl") (:form . "methyl") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "tertiary-butyl") (:form . "tertiary-butyl")\n  (:end . 88) (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "ether") (:form . "ether") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "benzene") (:form . "benzene") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "contaminating") (:form . "contaminating")\n  (:end . 120) (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "water") (:form . "water") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1093.1) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010178@unknown@formal@none@1@S@1. In this study we hypothesized that in individuals with certain genetic makeup, MTBE, benzene or their metabolites act as adducts and may induce programmed cell death.@(((:tag . "LS") (:stem . "1.") (:form . "1.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "In") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 32)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "makeup") (:form . "makeup") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MTBE") (:form . "MTBE") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "benzene") (:form . "benzene") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 104)\n  (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "adduct") (:form . "adducts") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 146)\n  (:start . 140) (:id . 67))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 157)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1093.2.1) (:span 136 139))\n  ((:id . :x1093.2.2) (:span 20 32)))\n (:hscopes ((:id . :x1093.2.1) (:span 136 168))\n  ((:id . :x1093.2.2) (:span 20 168)))\n (:identifiers (:sid . :s1093.2) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010180@unknown@formal@none@1@S@For comparison, we recruited a control group consisting of 32 healthy males and females with similar age distribution and without a history of exposure to MTBE or benzene.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "recruit") (:form . "recruited") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 117)\n  (:start . 105) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "history") (:form . "history") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 151)\n  (:start . 143) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mtbe") (:form . "MTBE") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "benzene") (:form . "benzene") (:end . 170)\n  (:start . 163) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x1093.4.1) (:span 122 129)))\n (:nscopes ((:id . :x1093.4.1) (:span 122 170)))\n (:identifiers (:sid . :s1093.4) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010181@unknown@formal@none@1@S@3. Peripheral blood lymphocytes (PBL) of both groups were tested for the percentage of apoptotic cells and cell cycle progression using flow cytometry.@(((:tag . "LS") (:stem . "3.") (:form . "3.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 64) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 129)\n  (:start . 118) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 135) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 150)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1093.5) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010182@unknown@formal@none@1@S@4. When apoptotic lymphocytes from exposed individuals were compared to apoptotic lymphocytes from the control group, statistically-significant differences between each mean group were detected (26.4 ± 1.8 and 12.1 ± 1.3, respectively), indicating an increased rate of apoptosis in 80.5% of exposed individuals (P < 0.0001, Mann-Whitney U-Test).@(((:tag . "LS") (:stem . "4.") (:form . "4.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . 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5010183@unknown@formal@none@1@S@MTBE and benzene-induced apoptosis is attributed to a discrete block within the cell cycle progression.@(((:tag . "NNP") (:stem . "MTBE") (:form . "MTBE") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "benzene-induced") (:form . "benzene-induced")\n  (:end . 24) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "discrete") (:form . "discrete") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1093.7) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010184@unknown@formal@none@1@S@Because cell cycle analysis showed that in PBL from chemically-exposed individuals, between 20-50% of cells were accumulated at the S-G2/M boundaries.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 34) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PBL") (:form . "PBL") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "chemically-exposed") (:form . "chemically-exposed")\n  (:end . 70) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "CD") (:stem . "20-50") (:form . "20-50") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "accumulate") (:form . "accumulated") (:end . 124)\n  (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "S-G2/M") (:form . "S-G2/M") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "boundary") (:form . "boundaries") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1093.8) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010185@unknown@formal@none@1@S@5. One of the signaling molecules which mediates programmed cell death is nuclear factor Kappa-B (NF-kappa B).@(((:tag . "LS") (:stem . "5.") (:form . "5.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "One") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 23)\n  (:start . 14) (:id . 46))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "Kappa-B") (:form . "Kappa-B") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1093.9) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010186@unknown@formal@none@1@S@NF-kappa B was examined as one of the many molecular mechanisms for mediating cell death by MTBE and benzene.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "MTBE") (:form . "MTBE") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "benzene") (:form . "benzene") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1093.10) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010187@unknown@formal@none@1@S@Indeed, addition of inhibitors of NF-kappa B activation pyrrolidine dithiocarbamate (PDTC), to the lymphocytes of the chemically-exposed group was capable of inhibiting programmed cell death by 40%.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 83) (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 110)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "chemically-exposed") (:form . "chemically-exposed")\n  (:end . 136) (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 168)\n  (:start . 158) (:id . 67))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 179)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 190)\n  (:start . 185) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 193) (:start . 191)\n  (:id . 71))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 196) (:start . 194)\n  (:id . 72))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1093.11) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010188@unknown@formal@none@1@S@This reversal of apoptosis almost to the control level by inhibitor of NF-kappa B activation may indicate involvement of this signaling molecule in MTBE and benzene induction of programmed cell death.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reversal") (:form . "reversal") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "MTBE") (:form . "MTBE") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "benzene") (:form . "benzene") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 188)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1093.12.1) (:span 97 105))\n  ((:id . :x1093.12.2) (:span 93 96)))\n (:hscopes ((:id . :x1093.12.1) (:span 97 199))\n  ((:id . :x1093.12.2) (:span 93 199)))\n (:identifiers (:sid . :s1093.12) (:did . :|9306134|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010190@unknown@formal@none@1@S@We have identified a novel gene, GR6, located within the leukemia breakpoint region of 3q21, that is normally expressed in early fetal development but not in adult peripheral blood.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GR6") (:form . "GR6") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 52)\n  (:start . 46) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "NN") (:stem . "breakpoint") (:form . "breakpoint") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "3q21") (:form . "3q21") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 119)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 146)\n  (:start . 135) (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 163)\n  (:start . 158) (:id . 71))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 174)\n  (:start . 164) (:id . 72))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 180)\n  (:start . 175) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1094.2.1) (:span 151 154)))\n (:nscopes ((:id . :x1094.2.1) (:span 151 180)))\n (:identifiers (:sid . :s1094.2) (:did . :|9307271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010191@unknown@formal@none@1@S@GR6 is activated in the UCSD-AML1 cell line and in a leukemic sample, both of which carry a t(3;3)(q21;q26).@(((:tag . "NNP") (:stem . "GR6") (:form . "GR6") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ucsd-aml1") (:form . "UCSD-AML1") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "carry") (:form . "carry") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t(3;3)(q21;q26)") (:form . "t(3;3)(q21;q26)")\n  (:end . 107) (:start . 92) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1094.3) (:did . :|9307271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010192@unknown@formal@none@1@S@In UCSD-AML1, we have also identified fusion transcripts between the ecotropic viral insertion site I (EVI1) gene in 3q26 and GR6 and between EVI1 and Ribophorin I that maps 30 kb telomeric to GR6 in 3q21.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "UCSD-AML1") (:form . "UCSD-AML1") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ecotropic") (:form . "ecotropic") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "EVI1") (:form . "EVI1") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "3q26") (:form . "3q26") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GR6") (:form . "GR6") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "NNP") (:stem . "EVI1") (:form . "EVI1") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Ribophorin") (:form . "Ribophorin") (:end . 161)\n  (:start . 151) (:id . 70))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 163) (:start . 162)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "map") (:form . "maps") (:end . 173) (:start . 169)\n  (:id . 73))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 176) (:start . 174)\n  (:id . 74))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 179) (:start . 177)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "telomeric") (:form . "telomeric") (:end . 189)\n  (:start . 180) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 192) (:start . 190)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "GR6") (:form . "GR6") (:end . 196) (:start . 193)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 79))\n ((:tag . "NN") (:stem . "3q21") (:form . "3q21") (:end . 204) (:start . 200)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1094.4) (:did . :|9307271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010193@unknown@formal@none@1@S@All fusions splice the 5' ends of the 3q21 genes into exon 2 of the EVI1 gene, an event that is similar to the normal intergenic splicing of MDS1-EVI1 and to those previously documented in leukemias with t(3;21) and t(3;12), in which acute myelogenous leukemia 1-EVI1 fusions and ETV6-EVI1 fusions, respectively, occur.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "fusion") (:form . "fusions") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "splice") (:form . "splice") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "end") (:form . "ends") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . 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5010194@unknown@formal@none@1@S@The Ribophorin I-EVI1 fusion in particular may be a common occurrence in t(3;3).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ribophorin") (:form . "Ribophorin") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "i-evi1") (:form . "I-EVI1") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "t(3;3)") (:form . "t(3;3)") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1094.6.1) (:span 43 46)))\n (:hscopes ((:id . :x1094.6.1) (:span 43 79)))\n (:identifiers (:sid . :s1094.6) (:did . :|9307271|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010195@unknown@formal@none@1@S@Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes.@(((:tag . "JJ") (:stem . "alcohol-induced") (:form . "Alcohol-induced")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 37)\n  (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 61)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 66) (:start . 62)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 85)\n  (:start . 76) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1095.1) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010196@unknown@formal@none@1@S@Acute ethanol exposure has the capacity to modulate immune functions, particularly, to down regulate monocyte production of inflammatory cytokines.@(((:tag . "JJ") (:stem . "acute") (:form . "Acute") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "RB") (:stem . "down") (:form . "down") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 136)\n  (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1095.2) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010197@unknown@formal@none@1@S@However, the intracellular mechanisms for these effects of ethanol are yet to be understood.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1095.3.1) (:span 71 91)))\n (:hscopes ((:id . :x1095.3.1) (:span 9 91)))\n (:identifiers (:sid . :s1095.3) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010198@unknown@formal@none@1@S@Considering that nuclear regulatory factor-kappa beta (NF-kappa B)/Rel is a common regulatory element of the promoter region of the inflammatory cytokine genes, herein, we tested the hypothesis that acute ethanol affects NF-kappa B activation in human monocytes.@(((:tag . "VBG") (:stem . "consider") (:form . "Considering") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 48)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 53) (:start . 49)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "NNP") (:stem . "B)/Rel") (:form . "B)/Rel") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 144)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 65))\n ((:tag . "RB") (:stem . "herein") (:form . "herein") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 178)\n  (:start . 172) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 193)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 198) (:start . 194)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 204)\n  (:start . 199) (:id . 73))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 212)\n  (:start . 205) (:id . 74))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 220)\n  (:start . 213) (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 229)\n  (:start . 221) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 231) (:start . 230)\n  (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 242)\n  (:start . 232) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 245) (:start . 243)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 251)\n  (:start . 246) (:id . 80))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 261)\n  (:start . 252) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1095.4.1) (:span 183 193)))\n (:hscopes ((:id . :x1095.4.1) (:span 183 261)))\n (:identifiers (:sid . :s1095.4) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010200@unknown@formal@none@1@S@A clinically relevant dose (25 mM) of acute ethanol treatment in vitro increased NF-kappa B binding activity in monocytes with a preferential induction of the inhibitory, p50/p50, NF-kappa B/Rel homodimer, and resulted in no induction of the p65/p50 heterodimer.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "mM") (:form . "mM") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 43) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 51)\n  (:start . 44) (:id . 52))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 61)\n  (:start . 52) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "preferential") (:form . "preferential") (:end . 141)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 151)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 169)\n  (:start . 159) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 188)\n  (:start . 180) (:id . 73))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 194)\n  (:start . 189) (:id . 74))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 204)\n  (:start . 195) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 218)\n  (:start . 210) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 79))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 224) (:start . 222)\n  (:id . 80))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 234)\n  (:start . 225) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 241) (:start . 238)\n  (:id . 83))\n ((:tag . "NN") (:stem . "p65/p50") (:form . "p65/p50") (:end . 249)\n  (:start . 242) (:id . 84))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 261)\n  (:start . 250) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x1095.6.1) (:span 222 224)))\n (:nscopes ((:id . :x1095.6.1) (:span 222 261)))\n (:identifiers (:sid . :s1095.6) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010201@unknown@formal@none@1@S@In contrast, lipopolysaccharide stimulation primarily induced the p65/p50 heterodimer that has been shown to result in gene activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 31) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 61)\n  (:start . 54) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p65/p50") (:form . "p65/p50") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 85)\n  (:start . 74) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1095.7) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010202@unknown@formal@none@1@S@Thus, such unique activation of the inhibitory p50/p50 homodimer by acute ethanol treatment may result in inhibition rather than activation of NF-kappa B-regulated inflammatory cytokine genes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "p50/p50") (:form . "p50/p50") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 91)\n  (:start . 82) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "JJ") (:stem . "b-regulated") (:form . "B-regulated") (:end . 163)\n  (:start . 152) (:id . 65))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 176)\n  (:start . 164) (:id . 66))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 185)\n  (:start . 177) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 191)\n  (:start . 186) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1095.8.2) (:span 92 95)))\n (:ncues ((:id . :x1095.8.1) (:span 117 128)))\n (:hscopes ((:id . :x1095.8.2) (:span 92 191)))\n (:nscopes ((:id . :x1095.8.1) (:span 117 191)))\n (:identifiers (:sid . :s1095.8) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010203@unknown@formal@none@1@S@Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 80) (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ethanol") (:form . "ethanol") (:end . 91)\n  (:start . 84) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 102)\n  (:start . 96) (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 129)\n  (:start . 117) (:id . 57))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 145) (:start . 141)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 154)\n  (:start . 149) (:id . 62))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 163)\n  (:start . 155) (:id . 63))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 176)\n  (:start . 164) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 191) (:start . 178) (:id . 66))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 196) (:start . 192)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin-6") (:form . "interleukin-6")\n  (:end . 215) (:start . 202) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 218) (:start . 216)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "disrupt") (:form . "disrupting") (:end . 229)\n  (:start . 219) (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 238)\n  (:start . 230) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 240) (:start . 239)\n  (:id . 74))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 250)\n  (:start . 241) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 253) (:start . 251)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 263)\n  (:start . 254) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1095.9.1) (:span 92 95))\n  ((:id . :x1095.9.2) (:span 28 35)))\n (:hscopes ((:id . :x1095.9.1) (:span 92 263))\n  ((:id . :x1095.9.2) (:span 28 263)))\n (:identifiers (:sid . :s1095.9) (:did . :|9309306|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010204@unknown@formal@none@1@S@Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins.@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "p-like") (:form . "P-like") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 183)\n  (:start . 177) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 192)\n  (:start . 184) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1096.1) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010205@unknown@formal@none@1@S@We previously identified the P sequence as a critical regulatory element of the human IL-4 promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1096.2) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010206@unknown@formal@none@1@S@In the mouse IL-4 promoter, there are five elements homologous to the human P sequence designated conserved lymphokine element 0 (CLE0), P, P2, P3 and P4.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "P2") (:form . "P2") (:end . 142) (:start . 140)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "P3") (:form . "P3") (:end . 146) (:start . 144)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "P4") (:form . "P4") (:end . 153) (:start . 151)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1096.3) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010207@unknown@formal@none@1@S@To characterize the role of these P-like elements and their binding factors in the native promoter, we did transient transfection and electrophoretic mobility shift assays (EMSA).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "p-like") (:form . "P-like") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 59)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "native") (:form . "native") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 129)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 149) (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 171)\n  (:start . 165) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1096.4) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010208@unknown@formal@none@1@S@Transfection of EL-4 cells with the IL-4 promoter-reporter constructs carrying mutated P-like elements showed that four P-like elements, CLE0, P, P2 and P4, but not P3, were required for optimal activation of the IL-4 promoter.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "promoter-reporter") (:form . "promoter-reporter")\n  (:end . 58) (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "JJ") (:stem . "p-like") (:form . "P-like") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 109)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 119) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "p-like") (:form . "P-like") (:end . 126)\n  (:start . 120) (:id . 58))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 135)\n  (:start . 127) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p2") (:form . "P2") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p4") (:form . "P4") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p3") (:form . "P3") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 173) (:start . 169)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 186) (:start . 183)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 194)\n  (:start . 187) (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 205)\n  (:start . 195) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 79))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 217) (:start . 213)\n  (:id . 80))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 226)\n  (:start . 218) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x1096.5.1) (:span 161 164)))\n (:nscopes ((:id . :x1096.5.1) (:span 161 167)))\n (:identifiers (:sid . :s1096.5) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010210@unknown@formal@none@1@S@In competition and antibody supershift assays in EMSA, complexes formed with P or P2 proved to contain nuclear factor of activated T cells (NFAT) family proteins as major components.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSA") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 71) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p2") (:form . "P2") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "prove") (:form . "proved") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 152)\n  (:start . 146) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 161)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 170)\n  (:start . 165) (:id . 72))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 181)\n  (:start . 171) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1096.7) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010211@unknown@formal@none@1@S@Activator protein (AP)-1 family proteins interacted with CLE0, P, P2 and P4.@(((:tag . "NNP") (:stem . "Activator") (:form . "Activator") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "AP)-1") (:form . "AP)-1") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CLE0") (:form . "CLE0") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p2") (:form . "P2") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p4") (:form . "P4") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1096.8) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010212@unknown@formal@none@1@S@NFAT/AP-1 complex formed only with P and P2.@(((:tag . "NN") (:stem . "nfat/ap-1") (:form . "NFAT/AP-1") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 24) (:start . 18)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p2") (:form . "P2") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1096.9) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010213@unknown@formal@none@1@S@Cross-competition assays among the P-like elements revealed element-specific and common complexes.@(((:tag . "NN") (:stem . "cross-competition") (:form . "Cross-competition")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 24)\n  (:start . 18) (:id . 43))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "p-like") (:form . "P-like") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "JJ") (:stem . "element-specific") (:form . "element-specific")\n  (:end . 76) (:start . 60) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 87)\n  (:start . 81) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 97)\n  (:start . 88) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1096.10) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010214@unknown@formal@none@1@S@Six tandem repeats of the P element linked to the SV40 promoter responded to phorbol 12-myristate 13-acetate, while that of other elements did not.@(((:tag . "CD") (:stem . "six") (:form . "Six") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "tandem") (:form . "tandem") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 42) (:start . 36)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SV40") (:form . "SV40") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 97)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1096.11.1) (:span 143 146)))\n (:nscopes ((:id . :x1096.11.1) (:span 143 146)))\n (:identifiers (:sid . :s1096.11) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010215@unknown@formal@none@1@S@It would thus appear that components of each P-like element-binding complexes are not identical and may coordinately contribute to transcriptional activity.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "p-like") (:form . "P-like") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 67) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "RB") (:stem . "coordinately") (:form . "coordinately") (:end . 116)\n  (:start . 104) (:id . 58))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 146) (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1096.12.1) (:span 100 103))\n  ((:id . :x1096.12.3) (:span 14 20)) ((:id . :x1096.12.4) (:span 3 8)))\n (:ncues ((:id . :x1096.12.2) (:span 82 85)))\n (:hscopes ((:id . :x1096.12.1) (:span 100 155))\n  ((:id . :x1096.12.3) (:span 14 155)) ((:id . :x1096.12.4) (:span 3 155)))\n (:nscopes ((:id . :x1096.12.2) (:span 82 95)))\n (:identifiers (:sid . :s1096.12) (:did . :|9310836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010216@unknown@formal@none@1@S@The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bhrf1") (:form . "BHRF1") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1097.1) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010217@unknown@formal@none@1@S@The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TNF)-") (:form . "TNF)-") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fas-mediated") (:form . "Fas-mediated") (:end . 110)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "virus-infected") (:form . "virus-infected")\n  (:end . 153) (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 177)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 187)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 206)\n  (:start . 195) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 73))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 217)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1097.2.1) (:span 160 163)))\n (:hscopes ((:id . :x1097.2.1) (:span 160 217)))\n (:identifiers (:sid . :s1097.2) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010218@unknown@formal@none@1@S@To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "protect") (:form . "protect") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "bhrf1") (:form . "BHRF1") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 125)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "early-lytic-cycle") (:form . "early-lytic-cycle")\n  (:end . 155) (:start . 138) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "distant") (:form . "distant") (:end . 176)\n  (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 185)\n  (:start . 177) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 188) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 198) (:start . 196)\n  (:id . 75))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 201) (:start . 199)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "anti-apoptosis") (:form . "anti-apoptosis")\n  (:end . 216) (:start . 202) (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 224)\n  (:start . 217) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1097.3) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010220@unknown@formal@none@1@S@In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BHRF1") (:form . "BHRF1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "protect") (:form . "protected") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocyte-mediated") (:form . "monocyte-mediated")\n  (:end . 63) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "killing") (:form . "killing") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 82) (:start . 76)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "VB") (:stem . "protect") (:form . "protect") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "kill") (:form . "killing") (:end . 111)\n  (:start . 104) (:id . 58))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphokine-activated")\n  (:form . "lymphokine-activated") (:end . 144) (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 151)\n  (:start . 145) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1097.5.1) (:span 76 82)))\n (:nscopes ((:id . :x1097.5.1) (:span 76 157)))\n (:identifiers (:sid . :s1097.5) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010221@unknown@formal@none@1@S@The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bhrf1") (:form . "BHRF1") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "protect") (:form . "protect") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NNP") (:stem . "MCF-Fas") (:form . "MCF-Fas") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Bcl-2") (:form . "Bcl-2") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Bcl-xL") (:form . "Bcl-xL") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1097.6) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010222@unknown@formal@none@1@S@Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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5010223@unknown@formal@none@1@S@A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bhrf1") (:form . "BHRF1") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ebv-infected") (:form . "EBV-infected") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "protect") (:form . "protect") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "virus-infected") (:form . "virus-infected")\n  (:end . 94) (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tnf-") (:form . "TNF-") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "anti-fas-") (:form . "anti-Fas-") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 146)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "VB") (:stem . "maximize") (:form . "maximize") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 184)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1097.8.1) (:span 62 65)) ((:id . :x1097.8.2) (:span 2 10)))\n (:hscopes ((:id . :x1097.8.1) (:span 62 184))\n  ((:id . :x1097.8.2) (:span 2 61)))\n (:identifiers (:sid . :s1097.8) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010224@unknown@formal@none@1@S@Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "bhrf1") (:form . "BHRF1") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "BJAB") (:form . "BJAB") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "protect") (:form . "protected") (:end . 85)\n  (:start . 76) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "anti-fas-mediated") (:form . "anti-Fas-mediated")\n  (:end . 118) (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "serum-starved") (:form . "serum-starved")\n  (:end . 185) (:start . 172) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1097.9.1) (:span 28 35 42 45)))\n (:nscopes ((:id . :x1097.9.1) (:span 28 128)))\n (:identifiers (:sid . :s1097.9) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010225@unknown@formal@none@1@S@Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bhrf1") (:form . "BHRF1") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "resemble") (:form . "resembles") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1097.10) (:did . :|9311830|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010226@unknown@formal@none@1@S@NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.@(((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "caml-interacting") (:form . "CAML-interacting")\n  (:end . 46) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1098.1) (:did . :|9311921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010227@unknown@formal@none@1@S@Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 119)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1098.2) (:did . :|9311921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010228@unknown@formal@none@1@S@The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "calcium-modulator") (:form . "calcium-modulator")\n  (:end . 27) (:start . 10) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cyclophilin") (:form . "cyclophilin") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "coinducer") (:form . "coinducer") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 113) (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1098.3) (:did . :|9311921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010230@unknown@formal@none@1@S@Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lymphocyte-specific")\n  (:form . "lymphocyte-specific") (:end . 41) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 49)\n  (:start . 42) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 61)\n  (:start . 51) (:id . 48))\n ((:tag . "NNP") (:stem . "TACI") (:form . "TACI") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 81) (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CAML-interactor") (:form . "CAML-interactor")\n  (:end . 111) (:start . 96) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 143)\n  (:start . 132) (:id . 61))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 150)\n  (:start . 144) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 156)\n  (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 161) (:start . 157)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "taci-specific") (:form . "TACI-specific")\n  (:end . 175) (:start . 162) (:id . 65))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 186)\n  (:start . 176) (:id . 66))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 190) (:start . 187)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 204)\n  (:start . 194) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 225) (:start . 212) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 233)\n  (:start . 226) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 239)\n  (:start . 234) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 240) (:start . 239)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 245) (:start . 241)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 246) (:start . 245)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 250) (:start . 247)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 259)\n  (:start . 251) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1098.5) (:did . :|9311921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010231@unknown@formal@none@1@S@TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate.@(((:tag . "JJ") (:stem . "taci-induced") (:form . "TACI-induced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 80) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "caml") (:form . "CAML") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "NNP") (:stem . "CAML") (:form . "CAML") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "intermediate") (:form . "intermediate") (:end . 143)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1098.6) (:did . :|9311921|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010232@unknown@formal@none@1@S@The DNA binding domain of the A-MYB transcription factor is responsible for its B cell-specific activity and binds to a B cell 110-kDa nuclear protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 95) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "110-kda") (:form . "110-kDa") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1099.1) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010233@unknown@formal@none@1@S@Expression studies as well as the use of transgenic animals have demonstrated that the A-MYB transcription factor plays central and specific role in the regulation of mature B cell proliferation and/or differentiation.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 77)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 163)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 173)\n  (:start . 167) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 194) (:start . 181) (:id . 71))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 201)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 217) (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1099.2) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010234@unknown@formal@none@1@S@Furthermore, it is highly expressed in Burkitt's lymphoma cells and may participate in the pathogenesis of this disease.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "participate") (:form . "participate") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1099.3.1) (:span 68 71)))\n (:hscopes ((:id . :x1099.3.1) (:span 68 119)))\n (:identifiers (:sid . :s1099.3) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010235@unknown@formal@none@1@S@We have therefore investigated the transcriptional activity of A-MYB and its regulation in several human lymphoid cell lines using co-transfection assays and show that A-MYB is transcriptionally active in all the B cell lines studied, but not in T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 50) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 130) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "co-transfection") (:form . "co-transfection")\n  (:end . 146) (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 153)\n  (:start . 147) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 162) (:start . 158)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 173)\n  (:start . 168) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 194) (:start . 177) (:id . 68))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 201)\n  (:start . 195) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 70))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 208) (:start . 205)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 214) (:start . 213)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 219) (:start . 215)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 225)\n  (:start . 220) (:id . 75))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 233)\n  (:start . 226) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 234) (:start . 233)\n  (:id . 77))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 238) (:start . 235)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 242) (:start . 239)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 245) (:start . 243)\n  (:id . 80))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 247) (:start . 246)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 253)\n  (:start . 248) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x1099.4.1) (:span 239 242)))\n (:nscopes ((:id . :x1099.4.1) (:span 239 253)))\n (:identifiers (:sid . :s1099.4) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010236@unknown@formal@none@1@S@In particular the best responder cell line was the Burkitt's cell line Namalwa.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "responder") (:form . "responder") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Namalwa") (:form . "Namalwa") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1099.5) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010237@unknown@formal@none@1@S@The activity of A-MYB in B and not T cells was observed when either an artificial construct or the c-MYC promoter was used as a reporter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 55)\n  (:start . 47) (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 67)\n  (:start . 61) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "artificial") (:form . "artificial") (:end . 81)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 91)\n  (:start . 82) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-MYC") (:end . 104) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 113)\n  (:start . 105) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 136)\n  (:start . 128) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1099.6.1) (:span 31 34)))\n (:nscopes ((:id . :x1099.6.1) (:span 31 42)))\n (:identifiers (:sid . :s1099.6) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010238@unknown@formal@none@1@S@Furthermore, the functional domains responsible for DNA binding, transactivation, and negative regulation, previously characterized in a fibroblast context, were found to have similar activity in B cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 80) (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 131) (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 155)\n  (:start . 148) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 167)\n  (:start . 162) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 192)\n  (:start . 184) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1099.7) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010240@unknown@formal@none@1@S@Finally, a 110-kDa protein has been identified in the nuclei of all the B, but not T, cell lines that specifically binds to this A-MYB N-terminal domain.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "110-kda") (:form . "110-kDa") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 90) (:start . 86)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 96) (:start . 91)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 64))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 114)\n  (:start . 102) (:id . 65))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 120)\n  (:start . 115) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 128) (:start . 124)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 134)\n  (:start . 129) (:id . 69))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 145)\n  (:start . 135) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 152)\n  (:start . 146) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1099.9.1) (:span 79 82)))\n (:nscopes ((:id . :x1099.9.1) (:span 79 84)))\n (:identifiers (:sid . :s1099.9) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010241@unknown@formal@none@1@S@We hypothesize that this 110-kDa protein may be a functionally important B cell-specific co-activator of A-MYB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "hypothesize") (:form . "hypothesize") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "110-kda") (:form . "110-kDa") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "co-activator") (:form . "co-activator") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "A-MYB") (:form . "A-MYB") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1099.10.1) (:span 41 44))\n  ((:id . :x1099.10.2) (:span 3 14)))\n (:hscopes ((:id . :x1099.10.1) (:span 41 110))\n  ((:id . :x1099.10.2) (:span 3 110)))\n (:identifiers (:sid . :s1099.10) (:did . :|9312094|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010242@unknown@formal@none@1@S@Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.@(((:tag . "NN") (:stem . "evidence") (:form . "Evidence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rate-limiting") (:form . "rate-limiting")\n  (:end . 42) (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1100.1) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010243@unknown@formal@none@1@S@Cyclosporine (CsA) is both a clinical immunosuppressive drug and a probe to dissect intracellular signaling pathways.@(((:tag . "NN") (:stem . "cyclosporine") (:form . "Cyclosporine") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 55) (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VB") (:stem . "dissect") (:form . "dissect") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 97) (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1100.2) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010244@unknown@formal@none@1@S@In vitro, CsA inhibits lymphocyte gene activation by inhibiting the phosphatase activity of calcineurin (CN).@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 103)\n  (:start . 92) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CN") (:form . "CN") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1100.3) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010245@unknown@formal@none@1@S@In clinical use, CsA treatment inhibits 50-75% of CN activity in circulating leukocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "CD") (:stem . "50-75") (:form . "50-75") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 76)\n  (:start . 65) (:id . 55))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 87)\n  (:start . 77) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1100.4) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010246@unknown@formal@none@1@S@We modeled this degree of CN inhibition in primary human leukocytes in vitro in order to study the effect of partial CN inhibition on the downstream signaling events that lead to gene activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "model") (:form . "modeled") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 119) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 130)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 158)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 165)\n  (:start . 159) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 175) (:start . 171)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 194)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1100.5) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010247@unknown@formal@none@1@S@In CsA-treated leukocytes stimulated by calcium ionophore, the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested: dephosphorylation of nuclear factor of activated T cell proteins, nuclear DNA binding, activation of a transfected reporter gene construct, IFN-gamma and IL-2 mRNA accumulation, and IFN-gamma production.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "csa-treated") (:form . "CsA-treated") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "calcium") (:form . 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5010248@unknown@formal@none@1@S@Furthermore, the degree of CN inhibition was reflected by a similar degree of reduction in lymphocyte proliferation and IFN-gamma production in the allogeneic mixed lymphocyte cultures.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reflect") (:form . "reflected") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 115) (:start . 102) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "allogeneic") (:form . "allogeneic") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "JJ") (:stem . "mixed") (:form . "mixed") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 184)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1100.7) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010250@unknown@formal@none@1@S@Thus, the reduction of CN activity observed in CsA-treated patients is accompanied by a similar degree of reduction in lymphocyte gene activation, and accounts for the immunosuppression observed.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 19)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cn") (:form . "CN") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "csa-treated") (:form . "CsA-treated") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 82)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "account") (:form . "accounts") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 185) (:start . 168) (:id . 70))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 194)\n  (:start . 186) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1100.9) (:did . :|9312192|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010251@unknown@formal@none@1@S@Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter.@(((:tag . "NNP") (:stem . "Cooperation") (:form . "Cooperation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B/rel") (:form . "B/rel") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 77)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 91) (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1101.1) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010252@unknown@formal@none@1@S@Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes.@(((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unrearranged") (:form . "unrearranged") (:end . 96)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "ch") (:form . "CH") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1101.2) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010253@unknown@formal@none@1@S@Subsequently, such primed cells can undergo switch recombination to express the selected new isotype.@(((:tag . "RB") (:stem . "subsequently") (:form . "Subsequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "primed") (:form . "primed") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1101.3) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010254@unknown@formal@none@1@S@In the case of IgE class switching, IL-4 activates the IgE germline promoter by inducing the interaction of the transcription factor STAT6 (IL-4STAT) with a responsive DNA element in the proximal region of the promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 104)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 125) (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IL-4STAT") (:form . "IL-4STAT") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 167)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 179)\n  (:start . 172) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 195)\n  (:start . 187) (:id . 75))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 202)\n  (:start . 196) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 218)\n  (:start . 210) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1101.4) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010255@unknown@formal@none@1@S@This study describes the characterization of two additional cis-acting elements that interact with members of the NF kappa B/rel transcription factor family in an IL-4-independent fashion.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 41) (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 70)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 106)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "NNP") (:stem . "B/rel") (:form . "B/rel") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 142) (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 149)\n  (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 156)\n  (:start . 150) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "il-4-independent") (:form . "IL-4-independent")\n  (:end . 179) (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 187)\n  (:start . 180) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1101.5) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010256@unknown@formal@none@1@S@Electrophoretic mobility shift assays show that the nucleoprotein complex formed on the upstream site (NF kappa B1) contains the classical p50/p65 heterodimer.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nucleoprotein") (:form . "nucleoprotein")\n  (:end . 65) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 80) (:start . 74)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "b1") (:form . "B1") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1101.6) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010257@unknown@formal@none@1@S@The complex on the proximal site (NF kappa B2) appears to be composed of p50 and relB.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 69)\n  (:start . 61) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "relB") (:form . "relB") (:end . 85) (:start . 81)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1101.7.1) (:span 47 54)))\n (:hscopes ((:id . :x1101.7.1) (:span 0 85)))\n (:identifiers (:sid . :s1101.7) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010258@unknown@formal@none@1@S@IgE germline promoter reporter gene constructs carrying point mutations in the NF kappa B2 site were largely unresponsive to IL-4 stimulation in transient transfection experiments, while plasmids with similar mutations in the NF kappa B1 site responded to cytokine stimulation better than the wild-type promoter.@(((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "carry") (:form . 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5010260@unknown@formal@none@1@S@In addition, the combination of a NF kappa B/rel binding site and the STAT6 response element conferred IL-4 inducibility to a heterologous minimal promoter, while the individual sites had no effect.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B/rel") (:form . "B/rel") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "VBD") (:stem . "confer") (:form . "conferred") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 120)\n  (:start . 108) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 138)\n  (:start . 126) (:id . 64))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 177)\n  (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 197)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x1101.10.1) (:span 188 190)))\n (:nscopes ((:id . :x1101.10.1) (:span 188 197)))\n (:identifiers (:sid . :s1101.10) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010261@unknown@formal@none@1@S@The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA-bound STAT6 to achieve IL-4-dependent activation of the human IgE germline gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "b2") (:form . "B2") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nucleoprotein") (:form . "nucleoprotein")\n  (:end . 61) (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "cooperate") (:form . "cooperate") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dna-bound") (:form . "DNA-bound") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "il-4-dependent") (:form . "IL-4-dependent")\n  (:end . 130) (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1101.11.1) (:span 70 73))\n  ((:id . :x1101.11.2) (:span 19 26)))\n (:hscopes ((:id . :x1101.11.1) (:span 70 172))\n  ((:id . :x1101.11.2) (:span 19 172)))\n (:identifiers (:sid . :s1101.11) (:did . :|9317131|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010262@unknown@formal@none@1@S@Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.@(((:tag . "JJ") (:stem . "dual") (:form . "Dual") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 88) (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1102.1) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010263@unknown@formal@none@1@S@Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 101) (:start . 86) (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1102.2) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010264@unknown@formal@none@1@S@This study tested the hypothesis that anti-LPS Abs neutralize endotoxin by blocking cellular uptake through mCD14.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 17) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-lps") (:form . "anti-LPS") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "neutralize") (:form . "neutralize") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1102.3.1) (:span 22 32)))\n (:hscopes ((:id . :x1102.3.1) (:span 22 113)))\n (:identifiers (:sid . :s1102.3) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010265@unknown@formal@none@1@S@Ab-associated changes in the uptake and cellular distribution of FITC-LPS were assessed by flow cytometry and laser scanning confocal microscopy in human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes.@(((:tag . "JJ") (:stem . "ab-associated") (:form . "Ab-associated")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FITC-LPS") (:form . "FITC-LPS") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "laser") (:form . "laser") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "scanning") (:form . "scanning") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "confocal") (:form . "confocal") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "JJ") (:stem . "cd14-transfected") (:form . "CD14-transfected")\n  (:end . 170) (:start . 154) (:id . 64))\n ((:tag . "JJ") (:stem . "chinese") (:form . "Chinese") (:end . 178)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "hamster") (:form . "hamster") (:end . 186)\n  (:start . 179) (:id . 66))\n ((:tag . "NN") (:stem . "ovary") (:form . "ovary") (:end . 192)\n  (:start . 187) (:id . 67))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 204)\n  (:start . 193) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cho-cd14") (:form . "CHO-CD14") (:end . 214)\n  (:start . 206) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 220)\n  (:start . 215) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 221) (:start . 220)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 231)\n  (:start . 226) (:id . 74))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 242)\n  (:start . 232) (:id . 75))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 248)\n  (:start . 243) (:id . 76))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 258)\n  (:start . 249) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1102.4) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010266@unknown@formal@none@1@S@LPS core- and O-side chain-specific mAbs inhibited mCD14-mediated LPS uptake by both cell types in the presence of serum.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core-") (:form . "core-") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "o-side") (:form . "O-side") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "chain-specific") (:form . "chain-specific")\n  (:end . 35) (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "mcd14-mediated") (:form . "mCD14-mediated")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1102.5) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010267@unknown@formal@none@1@S@O-side chain-specific mAb concurrently enhanced complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s).@(((:tag . "JJ") (:stem . "o-side") (:form . "O-side") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chain-specific") (:form . "chain-specific")\n  (:end . 21) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "RB") (:stem . "concurrently") (:form . "concurrently") (:end . 38)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "JJ") (:stem . "complement-dependent")\n  (:form . "complement-dependent") (:end . 68) (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 72) (:start . 69)\n  (:id . 48))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 79)\n  (:start . 73) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 92)\n  (:start . 83) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 100)\n  (:start . 93) (:id . 52))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 111)\n  (:start . 101) (:id . 53))\n ((:tag . "NN") (:stem . "receptor-1") (:form . "receptor-1") (:end . 122)\n  (:start . 112) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cr1") (:form . "CR1") (:end . 127) (:start . 124)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 58))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 139)\n  (:start . 133) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cho-cd14") (:form . "CHO-CD14") (:end . 151)\n  (:start . 143) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 62))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 167)\n  (:start . 158) (:id . 63))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 175)\n  (:start . 168) (:id . 64))\n ((:tag . "JJ") (:stem . "heat-labile") (:form . "heat-labile") (:end . 187)\n  (:start . 176) (:id . 65))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 193)\n  (:start . 188) (:id . 66))\n ((:tag . "NNS") (:stem . "factor(s)") (:form . "factor(s)") (:end . 203)\n  (:start . 194) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cell-associated") (:form . "cell-associated")\n  (:end . 223) (:start . 208) (:id . 69))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 235)\n  (:start . 224) (:id . 70))\n ((:tag . "NNS") (:stem . "molecule(s)") (:form . "molecule(s)") (:end . 247)\n  (:start . 236) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1102.6) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010268@unknown@formal@none@1@S@Core-specific mAb inhibited mCD14-mediated uptake of homologous and heterologous LPS, while producing less concurrent enhancement of non-mCD14-mediated LPS uptake.@(((:tag . "JJ") (:stem . "core-specific") (:form . "Core-specific")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "mcd14-mediated") (:form . "mCD14-mediated")\n  (:end . 42) (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 49)\n  (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 80)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 84) (:start . 81)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 91) (:start . 86)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "concurrent") (:form . "concurrent") (:end . 117)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 129)\n  (:start . 118) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-mcd14-mediated") (:form . "non-mCD14-mediated")\n  (:end . 151) (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 155) (:start . 152)\n  (:id . 60))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 162)\n  (:start . 156) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1102.7) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010270@unknown@formal@none@1@S@LPS-specific Abs thus mediate anti-inflammatory and proinflammatory functions, respectively, by preventing target cell uptake of LPS through mCD14 and augmenting uptake through CR1 or other cell receptors.@(((:tag . "JJ") (:stem . "lps-specific") (:form . "LPS-specific") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ab") (:form . "Abs") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 47) (:start . 30) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 67) (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 77)\n  (:start . 68) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 50))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 91)\n  (:start . 79) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 113)\n  (:start . 107) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 56))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 140)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "augment") (:form . "augmenting") (:end . 161)\n  (:start . 151) (:id . 63))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 168)\n  (:start . 162) (:id . 64))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 176)\n  (:start . 169) (:id . 65))\n ((:tag . "NN") (:stem . "cr1") (:form . "CR1") (:end . 180) (:start . 177)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 189)\n  (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 194) (:start . 190)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 204)\n  (:start . 195) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1102.9) (:did . :|9317151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010271@unknown@formal@none@1@S@Human neutrophils express GH-N gene transcripts and the pituitary transcription factor Pit-1b.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "gh-n") (:form . "GH-N") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 86)\n  (:start . 80) (:id . 52))\n ((:tag . "NNP") (:stem . "Pit-1b") (:form . "Pit-1b") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1103.1) (:did . :|9322967|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010272@unknown@formal@none@1@S@Since GH stimulates the development and function of granulocytes, we investigated the expression of GH in granulocyte subsets.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 117)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1103.2) (:did . :|9322967|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010273@unknown@formal@none@1@S@By immunocytochemistry, 25 ± 7% of the human neutrophils were shown to express immunoreactive GH, whereas eosinophils were negative.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunocytochemistry")\n  (:form . "immunocytochemistry") (:end . 22) (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 56)\n  (:start . 45) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "JJ") (:stem . "immunoreactive") (:form . "immunoreactive")\n  (:end . 93) (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "gh") (:form . "GH") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1103.3) (:did . :|9322967|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010274@unknown@formal@none@1@S@Reversed transcription (RT)-PCR analysis demonstrated GH mRNA in neutrophils.@(((:tag . "VBN") (:stem . "reverse") (:form . "Reversed") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RT)-PCR") (:form . "RT)-PCR") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 53)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "GH") (:form . "GH") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1103.4) (:did . :|9322967|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010275@unknown@formal@none@1@S@Restriction analysis revealed that neutrophils express the GH-N gene but not the GH-V gene.@(((:tag . "NN") (:stem . "restriction") (:form . "Restriction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GH-N") (:form . "GH-N") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GH-V") (:form . "GH-V") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1103.5.1) (:span 73 76)))\n (:nscopes ((:id . :x1103.5.1) (:span 73 90)))\n (:identifiers (:sid . :s1103.5) (:did . :|9322967|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010276@unknown@formal@none@1@S@Furthermore, we demonstrated by western blot analysis that neutrophils express an alternatively spliced variant of the pituitary transcription factor Pit-1, designated Pit-1b.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "western") (:form . "western") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "RB") (:stem . "alternatively") (:form . "alternatively")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "VBN") (:stem . "splice") (:form . "spliced") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pituitary") (:form . "pituitary") (:end . 128)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 142) (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 149)\n  (:start . 143) (:id . 61))\n ((:tag . "NN") (:stem . "pit-1") (:form . "Pit-1") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 167)\n  (:start . 157) (:id . 64))\n ((:tag . "NNP") (:stem . "Pit-1b") (:form . "Pit-1b") (:end . 174)\n  (:start . 168) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1103.6) (:did . :|9322967|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010277@unknown@formal@none@1@S@Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1.@(((:tag . "NNP") (:stem . "Interleukin-7") (:form . "Interleukin-7")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "upregulate") (:form . "upregulates") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "interleukin-2-gene") (:form . "interleukin-2-gene")\n  (:end . 48) (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 72)\n  (:start . 63) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 92)\n  (:start . 81) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 115) (:start . 100) (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 121)\n  (:start . 116) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "enhance") (:form . "enhancing") (:end . 134)\n  (:start . 125) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 142) (:start . 139)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 150)\n  (:start . 143) (:id . 60))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 161)\n  (:start . 151) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 169) (:start . 165)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 177)\n  (:start . 170) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 184)\n  (:start . 178) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 197)\n  (:start . 188) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 199) (:start . 198)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 205)\n  (:start . 200) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 219)\n  (:start . 210) (:id . 71))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 229)\n  (:start . 220) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1104.1) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010278@unknown@formal@none@1@S@In the present report, we studied the role of the stromal-derived cytokine interleukin-7 (IL-7) in the IL-2-gene regulation in activated T lymphocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "stromal-derived") (:form . "stromal-derived")\n  (:end . 65) (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-7") (:form . "interleukin-7")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "il-2-gene") (:form . "IL-2-gene") (:end . 112)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 150)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1104.2) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010280@unknown@formal@none@1@S@T-cell receptor (TCR)/CD3 engagement results in the activation of nuclear factor of activated T cells (NFAT), activator protein-1 (AP-1), and nuclear factor kappaB (NFkappaB), whereas the CD28 responsive complex (CD28RC) is activated in response to the CD28 signal.@(((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "TCR)/CD3") (:form . "TCR)/CD3") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . 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"CD28") (:end . 257) (:start . 253)\n  (:id . 90))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 264)\n  (:start . 258) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s1104.4) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010281@unknown@formal@none@1@S@Costimulation of phytohemagglutinin/anti-CD28 activated T lymphocytes with IL-7 induces a fivefold enhanced IL-2-mRNA accumulation and a 2.5-fold enhanced protein secretion.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phytohemagglutinin/anti-cd28")\n  (:form . "phytohemagglutinin/anti-CD28") (:end . 45) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 55)\n  (:start . 46) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 69)\n  (:start . 58) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 74) (:start . 70)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 79) (:start . 75)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 87)\n  (:start . 80) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 51))\n ((:tag . "RB") (:stem . "fivefold") (:form . "fivefold") (:end . 98)\n  (:start . 90) (:id . 52))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "NNP") (:stem . "IL-2-mRNA") (:form . "IL-2-mRNA") (:end . 117)\n  (:start . 108) (:id . 54))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 130)\n  (:start . 118) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 57))\n ((:tag . "RB") (:stem . "2.5-fold") (:form . "2.5-fold") (:end . 145)\n  (:start . 137) (:id . 58))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 154)\n  (:start . 146) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 60))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 172)\n  (:start . 163) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1104.5) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010282@unknown@formal@none@1@S@The IL-2-gene transcription rate is increased 3.4-fold, indicating that the effect of IL-7 is in part mediated at the transcriptional level.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "il-2-gene") (:form . "IL-2-gene") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "RB") (:stem . "3.4-fold") (:form . "3.4-fold") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 133) (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1104.6.1) (:span 56 71)))\n (:hscopes ((:id . :x1104.6.1) (:span 56 139)))\n (:identifiers (:sid . :s1104.6) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010283@unknown@formal@none@1@S@The molecular mechanisms underlying the IL-7 effect involve the upregulation of the DNA binding activity of NFAT (60%) and AP-1 (120%), without affecting the activities of NFkappaB and CD28RC, which was confirmed by transfection assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 143)\n  (:start . 136) (:id . 70))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 153)\n  (:start . 144) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 168)\n  (:start . 158) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 180)\n  (:start . 172) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "CD28RC") (:form . "CD28RC") (:end . 191)\n  (:start . 185) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 198)\n  (:start . 193) (:id . 79))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 202) (:start . 199)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 212)\n  (:start . 203) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 215) (:start . 213)\n  (:id . 82))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 228)\n  (:start . 216) (:id . 83))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 235)\n  (:start . 229) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x1104.7.1) (:span 136 143)))\n (:nscopes ((:id . :x1104.7.1) (:span 136 191)))\n (:identifiers (:sid . :s1104.7) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010284@unknown@formal@none@1@S@We also show that the IL-7-induced enhancement of the AP-1-DNA binding activity is not cyclosporin A-sensitive.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "il-7-induced") (:form . "IL-7-induced") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AP-1-DNA") (:form . "AP-1-DNA") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 98)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "a-sensitive") (:form . "A-sensitive") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1104.8.1) (:span 83 86)))\n (:nscopes ((:id . :x1104.8.1) (:span 83 110)))\n (:identifiers (:sid . :s1104.8) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010285@unknown@formal@none@1@S@Since AP-1 is part of the NFAT complex, we conclude that the IL-7-signaling pathway is involved in the activation of the fos and jun proteins of which AP-1 consists.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "il-7-signaling") (:form . "IL-7-signaling")\n  (:end . 75) (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 150)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 155) (:start . 151)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 164)\n  (:start . 156) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1104.9) (:did . :|9326236|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010286@unknown@formal@none@1@S@Analysis of myeloid-associated genes in human hematopoietic progenitor cells.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "myeloid-associated") (:form . "myeloid-associated")\n  (:end . 30) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1105.1) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010287@unknown@formal@none@1@S@The distribution of myeloid lineage-associated cytokine receptors and lysosomal proteins was analyzed in human CD34+ cord blood cell (CB) subsets at different stages of myeloid commitment by reverse-transcriptase polymerase chain reaction (RT-PCR).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "lineage-associated") (:form . "lineage-associated")\n  (:end . 46) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 65)\n  (:start . 56) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 88)\n  (:start . 80) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 101)\n  (:start . 93) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 55))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 116)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 121) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 127)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 132) (:start . 128)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CB") (:form . "CB") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "commitment") (:form . "commitment") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "reverse-transcriptase")\n  (:form . "reverse-transcriptase") (:end . 212) (:start . 191) (:id . 71))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 223)\n  (:start . 213) (:id . 72))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 229)\n  (:start . 224) (:id . 73))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 238)\n  (:start . 230) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 240) (:start . 239)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 246)\n  (:start . 240) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 247) (:start . 246)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1105.2) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010288@unknown@formal@none@1@S@The highly specific granulomonocyte-associated lysosomal proteins myeloperoxidase (MPO) and lysozyme (LZ), as well as the transcription factor PU.1, were already detectable in the most immature CD34+Thy-1+ subset.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "granulomonocyte-associated")\n  (:form . "granulomonocyte-associated") (:end . 46) (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 56)\n  (:start . 47) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 65)\n  (:start . 57) (:id . 47))\n ((:tag . "NN") (:stem . "myeloperoxidase") (:form . "myeloperoxidase")\n  (:end . 81) (:start . 66) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MPO") (:form . "MPO") (:end . 86) (:start . 83)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lysozyme") (:form . "lysozyme") (:end . 100)\n  (:start . 92) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LZ") (:form . "LZ") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "pu.1") (:form . "PU.1") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 193)\n  (:start . 185) (:id . 72))\n ((:tag . "JJ") (:stem . "cd34+thy-1+") (:form . "CD34+Thy-1+") (:end . 205)\n  (:start . 194) (:id . 73))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 212)\n  (:start . 206) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1105.3) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010290@unknown@formal@none@1@S@By contrast, the monocyte-macrophage colony stimulating factor (M-CSF) receptor was largely absent at this stage and in the CD34+Thy-1-CD45RA- subsets.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monocyte-macrophage")\n  (:form . "monocyte-macrophage") (:end . 36) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "stimulating") (:form . "stimulating") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cd34+thy-1-cd45ra-") (:form . "CD34+Thy-1-CD45RA-")\n  (:end . 142) (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1105.5.1) (:span 92 98)))\n (:nscopes ((:id . :x1105.5.1) (:span 13 150)))\n (:identifiers (:sid . :s1105.5) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010291@unknown@formal@none@1@S@The M-CSF receptor was first detectable in the myeloid-committed CD34+Thy-l-CD45RA+ subset.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid-committed") (:form . "myeloid-committed")\n  (:end . 64) (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "cd34+thy-l-cd45ra+") (:form . "CD34+Thy-l-CD45RA+")\n  (:end . 83) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 90)\n  (:start . 84) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1105.6) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010292@unknown@formal@none@1@S@All other molecules studied were found to be expressed at this stage of differentiation.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 87) (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1105.7) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010293@unknown@formal@none@1@S@Different cocktails of the identified ligands were added to sorted CD34+Thy-1+ single cells.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cocktail") (:form . "cocktails") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "sort") (:form . "sorted") (:end . 66) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cd34+thy-1+") (:form . "CD34+Thy-1+") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1105.8) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010294@unknown@formal@none@1@S@Low proliferative capacity was observed after 1 week in culture in the presence of stem cell factor (SCF) + Flt-3 ligand (FL) + G-CSF.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "week") (:form . "week") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SCF") (:form . "SCF") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "+") (:form . "+") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Flt-3") (:form . "Flt-3") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 120)\n  (:start . 114) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "FL") (:form . "FL") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "+") (:form . "+") (:end . 127) (:start . 126)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 133)\n  (:start . 128) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1105.9) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010295@unknown@formal@none@1@S@Addition of GM-CSF to this basic cocktail consistently increased the clonogenic capacity of single CD34+Thy-1+ cells, and this effect was further enhanced (up to 72.3 ± 4.3% on day 7) by the inclusion of TNF-alpha.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cocktail") (:form . "cocktail") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "clonogenic") (:form . "clonogenic") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "JJ") (:stem . "cd34+thy-1+") (:form . "CD34+Thy-1+") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 145)\n  (:start . 138) (:id . 63))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "CD") (:stem . "72.3") (:form . "72.3") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "CD") (:stem . "4.3") (:form . "4.3") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "day") (:form . "day") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 77))\n ((:tag . "NN") (:stem . "inclusion") (:form . "inclusion") (:end . 200)\n  (:start . 191) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 213)\n  (:start . 204) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1105.10) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010296@unknown@formal@none@1@S@In conclusion, the presence of myeloid-associated growth factor receptor transcripts in CD34+ CB subsets does not discriminate the various stages of differentiation, with the exception of the M-CSF receptor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid-associated") (:form . "myeloid-associated")\n  (:end . 49) (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cd34+") (:form . "CD34+") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CB") (:form . "CB") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "VB") (:stem . "discriminate") (:form . "discriminate") (:end . 126)\n  (:start . 114) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 164) (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 184)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "M-CSF") (:form . "M-CSF") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 206)\n  (:start . 198) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1105.11.1) (:span 166 187))\n  ((:id . :x1105.11.2) (:span 110 113)))\n (:nscopes ((:id . :x1105.11.1) (:span 166 206))\n  ((:id . :x1105.11.2) (:span 110 206)))\n (:identifiers (:sid . :s1105.11) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010297@unknown@formal@none@1@S@In addition, we show that TNF-alpha is a potent costimulatory factor of the very immature CD34+Thy-1+ CB subset.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 47)\n  (:start . 41) (:id . 51))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 61) (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "cd34+thy-1+") (:form . "CD34+Thy-1+") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "CB") (:form . "CB") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1105.12) (:did . :|9328452|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010298@unknown@formal@none@1@S@Monochloramine inhibits phorbol ester-inducible neutrophil respiratory burst activation and T cell interleukin-2 receptor expression by inhibiting inducible protein kinase C activity.@(((:tag . "NNP") (:stem . "Monochloramine") (:form . "Monochloramine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "JJ") (:stem . "ester-inducible") (:form . "ester-inducible")\n  (:end . 47) (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 58)\n  (:start . 48) (:id . 46))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 70)\n  (:start . 59) (:id . 47))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 76) (:start . 71)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 93) (:start . 92)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 112) (:start . 99) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 121)\n  (:start . 113) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 132)\n  (:start . 122) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 146)\n  (:start . 136) (:id . 57))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 156)\n  (:start . 147) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 171)\n  (:start . 165) (:id . 60))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 173) (:start . 172)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 182)\n  (:start . 174) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1106.1) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010300@unknown@formal@none@1@S@The effects of chemically prepared monochloramine (NH2Cl) on protein kinase C (PKC) and PKC-mediated cellular responses were studied in elicited rat peritoneal neutrophils and human Jurkat T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "chemically") (:form . "chemically") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "monochloramine") (:form . "monochloramine")\n  (:end . 49) (:start . 35) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NH2Cl") (:form . "NH2Cl") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pkc-mediated") (:form . "PKC-mediated") (:end . 100)\n  (:start . 88) (:id . 59))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "peritoneal") (:form . "peritoneal") (:end . 159)\n  (:start . 149) (:id . 67))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 171)\n  (:start . 160) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 188)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1106.3) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010301@unknown@formal@none@1@S@Neutrophils pretreated with NH2Cl (30-50 microM) showed a marked decrease in the respiratory burst activity induced by phorbol 12-myristate 13-acetate (PMA), which is a potent PKC activator.@(((:tag . "NNS") (:stem . "neutrophil") (:form . "Neutrophils") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NH2Cl") (:form . "NH2Cl") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "CD") (:stem . "30-50") (:form . "30-50") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 175)\n  (:start . 169) (:id . 71))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1106.4) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010302@unknown@formal@none@1@S@These cells, however, were viable and showed a complete respiratory burst upon arachidonic acid stimulation, which induces the respiratory burst by a PKC-independent mechanism.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 33)\n  (:start . 27) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 44) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "arachidonic") (:form . "arachidonic") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 138)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "burst") (:form . "burst") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "pkc-independent") (:form . "PKC-independent")\n  (:end . 165) (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 175)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1106.5) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010303@unknown@formal@none@1@S@The NH2Cl-treated neutrophils showed a decrease in both PKC activity and PMA-induced phosphorylation of a 47-kDa protein, which corresponds to the cytosolic factor of NADPH oxidase, p47(phox).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nh2cl-treated") (:form . "NH2Cl-treated")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 36) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 100) (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "47-kda") (:form . "47-kDa") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 139)\n  (:start . 128) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NADPH") (:form . "NADPH") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "oxidase") (:form . "oxidase") (:end . 180)\n  (:start . 173) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "p47(phox)") (:form . "p47(phox)") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1106.6) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010304@unknown@formal@none@1@S@Jurkat T cells pretreated with NH2Cl (20-70 microM) showed a decrease in the expression of the interleukin-2 receptor alpha chain following PMA stimulation.@(((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "pretreate") (:form . "pretreated") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NH2Cl") (:form . "NH2Cl") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "20-70") (:form . "20-70") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 58) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 108) (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1106.7) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010305@unknown@formal@none@1@S@This was also accompanied by a decrease in both PKC activity and nuclear transcription factor-kappaB activation, also without loss of cell viability.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 86) (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 100) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1106.8.1) (:span 118 125)))\n (:nscopes ((:id . :x1106.8.1) (:span 118 148)))\n (:identifiers (:sid . :s1106.8) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010306@unknown@formal@none@1@S@These results show that NH2Cl inhibits PKC-mediated cellular responses through inhibition of the inducible PKC activity.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NH2Cl") (:form . "NH2Cl") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "pkc-mediated") (:form . "PKC-mediated") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 78)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1106.9) (:did . :|9334193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010307@unknown@formal@none@1@S@HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B [see comments]@(((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1107.1) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010308@unknown@formal@none@1@S@The HIV-1 accessory gene product Vpr can influence viral pathogenesis by affecting viral replication as well as host cell transcription and proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "accessory") (:form . "accessory") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 100)\n  (:start . 89) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 153) (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1107.2) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010310@unknown@formal@none@1@S@However, we have also found that Vpr modulates T-cell receptor (TCR)-triggered apoptosis in a manner similar to that of glucocorticoids.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "TCR)-triggered") (:form . "TCR)-triggered")\n  (:end . 78) (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 135) (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1107.4) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010311@unknown@formal@none@1@S@In the absence of TCR-mediated activation, Vpr induces apoptosis whereas in its presence, Vpr interrupts the expected induction of apoptosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tcr-mediated") (:form . "TCR-mediated") (:end . 30)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "interrupt") (:form . "interrupts") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1107.5.1) (:span 7 14)))\n (:nscopes ((:id . :x1107.5.1) (:span 7 41)))\n (:identifiers (:sid . :s1107.5) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010312@unknown@formal@none@1@S@This regulation of apoptosis is linked to Vpr suppression of NF-kappa B activity via the induction of I kappa B, an inhibitor of NF-kappa B.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 38) (:start . 32)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vpr") (:form . "Vpr") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 125)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 137)\n  (:start . 129) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1107.6) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010313@unknown@formal@none@1@S@Further, Vpr suppresses expression of IL-2, IL-10, IL-12, TNF alpha and IL-4, all of which are NF-kappa B-dependent.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 67) (:start . 62)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 81) (:start . 78)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 94) (:start . 91)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 103)\n  (:start . 95) (:id . 63))\n ((:tag . "JJ") (:stem . "b-dependent") (:form . "B-dependent") (:end . 115)\n  (:start . 104) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1107.7) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010314@unknown@formal@none@1@S@The effects of Vpr could be reversed by RU486.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ru486") (:form . "RU486") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1107.8) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010315@unknown@formal@none@1@S@Our finding that Vpr can regulate NF-kappa B supports the hypothesis that some aspects of viral pathogenesis are the consequence of cell dysregulation by Vpr.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 108)\n  (:start . 96) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 128)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 150) (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Vpr") (:form . "Vpr") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1107.9.1) (:span 58 68)))\n (:hscopes ((:id . :x1107.9.1) (:span 58 157)))\n (:identifiers (:sid . :s1107.9) (:did . :|9334723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010316@unknown@formal@none@1@S@The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 82) (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "c-sis/platelet-derived")\n  (:form . "c-sis/platelet-derived") (:end . 112) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 119)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "factor-b") (:form . "factor-B") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 145)\n  (:start . 138) (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 158)\n  (:start . 146) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 163) (:start . 159)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 172) (:start . 168)\n  (:id . 65))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 179)\n  (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 193) (:start . 180) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 201)\n  (:start . 194) (:id . 68))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 205) (:start . 202)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ngfi-a/egr-1") (:form . "NGFI-A/Egr-1") (:end . 222)\n  (:start . 210) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1108.1) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010317@unknown@formal@none@1@S@Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as one possible mechanism of cellular transformation by human T-cell leukemia virus type 1.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 29) (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "c-sis/platelet-derived")\n  (:form . "c-sis/platelet-derived") (:end . 59) (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 66)\n  (:start . 60) (:id . 47))\n ((:tag . "NN") (:stem . "factor-b") (:form . "factor-B") (:end . 75)\n  (:start . 67) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PDGF-B") (:form . "PDGF-B") (:end . 83)\n  (:start . 77) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 99) (:start . 85) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 110) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 118)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 154) (:start . 150)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 176)\n  (:start . 166) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 179) (:start . 177)\n  (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 192)\n  (:start . 184) (:id . 69))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 202)\n  (:start . 193) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 214)\n  (:start . 206) (:id . 72))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 229) (:start . 215) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 232) (:start . 230)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 238)\n  (:start . 233) (:id . 75))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 245)\n  (:start . 239) (:id . 76))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 254)\n  (:start . 246) (:id . 77))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 260)\n  (:start . 255) (:id . 78))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 265) (:start . 261)\n  (:id . 79))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 267) (:start . 266)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1108.2.1) (:span 184 192)))\n (:hscopes ((:id . :x1108.2.1) (:span 184 267)))\n (:identifiers (:sid . :s1108.2) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010318@unknown@formal@none@1@S@In previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive element 1 (TRE1), necessary for transactivation by Tax.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "c-sis/pdgf-b") (:form . "c-sis/PDGF-B") (:end . 69)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "tax-responsive") (:form . "Tax-responsive")\n  (:end . 94) (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TRE1") (:form . "TRE1") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 122)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 142) (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1108.3) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010320@unknown@formal@none@1@S@In the present work, we have investigated the mechanism(s) whereby Tax transactivates the c-sis/PDGF-B proto-oncogene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 41)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 58)\n  (:start . 46) (:id . 51))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "transactivate") (:form . "transactivates")\n  (:end . 85) (:start . 71) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-sis/pdgf-b") (:form . "c-sis/PDGF-B") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 117) (:start . 103) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1108.5) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010321@unknown@formal@none@1@S@In vitro transcription assays showed that Tax was able to significantly increase the transcriptional activity of a template containing the -257 to +74 region of the c-sis/PDGF-B promoter.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 36) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "template") (:form . "template") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-257") (:form . "-257") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "CD") (:stem . "+74") (:form . "+74") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 157)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c-sis/pdgf-b") (:form . "c-sis/PDGF-B") (:end . 177)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 186)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1108.6) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010322@unknown@formal@none@1@S@Electrophoretic mobility shift assay analysis showed that Tax increased the DNA binding activity of both Sp1 and NGFI-A/Egr-1 using a TRE1 probe.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 52) (:start . 46)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ngfi-a/egr-1") (:form . "NGFI-A/Egr-1") (:end . 125)\n  (:start . 113) (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 131) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tre1") (:form . "TRE1") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1108.7) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010323@unknown@formal@none@1@S@Analysis of Tax mutants showed that two mutants, IEXC29S and IEXL320G, were unable to significantly transactivate the c-sis/PDGF-B promoter.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 30) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IEXC29S") (:form . "IEXC29S") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IEXL320G") (:form . "IEXL320G") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 99) (:start . 86) (:id . 58))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 113) (:start . 100) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-sis/pdgf-b") (:form . "c-sis/PDGF-B") (:end . 130)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1108.8.1) (:span 76 82)))\n (:nscopes ((:id . :x1108.8.1) (:span 36 139)))\n (:identifiers (:sid . :s1108.8) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010324@unknown@formal@none@1@S@Finally, co-immunoprecipitation analysis revealed that Tax is able to stably bind to both Sp1 and NGFI-A/Egr-1.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "co-immunoprecipitation")\n  (:form . "co-immunoprecipitation") (:end . 31) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 40)\n  (:start . 32) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ngfi-a/egr-1") (:form . "NGFI-A/Egr-1") (:end . 110)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1108.9) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010325@unknown@formal@none@1@S@Interestingly, co-immunoprecipitation analysis also revealed that Tax mutant IEXC29S is unable to interact with NGFI-A/Egr-1, whereas Tax mutant IEXL320G is able to interact with NGFI-A/Egr-1.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "co-immunoprecipitation")\n  (:form . "co-immunoprecipitation") (:end . 37) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 46)\n  (:start . 38) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 51) (:start . 47)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 60)\n  (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 76)\n  (:start . 70) (:id . 50))\n ((:tag . "NN") (:stem . "iexc29s") (:form . "IEXC29S") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ngfi-a/egr-1") (:form . "NGFI-A/Egr-1") (:end . 124)\n  (:start . 112) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 133)\n  (:start . 126) (:id . 59))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 144)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "iexl320g") (:form . "IEXL320G") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 161) (:start . 157)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 173)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ngfi-a/egr-1") (:form . "NGFI-A/Egr-1") (:end . 191)\n  (:start . 179) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1108.10.1) (:span 88 94)))\n (:nscopes ((:id . :x1108.10.1) (:span 66 124)))\n (:identifiers (:sid . :s1108.10) (:did . :|9341193|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010326@unknown@formal@none@1@S@Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 170) (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 177)\n  (:start . 171) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 186)\n  (:start . 178) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 188) (:start . 187)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1109.1) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010327@unknown@formal@none@1@S@Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J. Biol. Chem. 1995: 270: 10631).@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "indicate") (:form . 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"1995") (:end . 293) (:start . 289)\n  (:id . 88))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 294) (:start . 293)\n  (:id . 89))\n ((:tag . "CD") (:stem . "270") (:form . "270") (:end . 298) (:start . 295)\n  (:id . 90))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 299) (:start . 298)\n  (:id . 91))\n ((:tag . "CD") (:stem . "10631") (:form . "10631") (:end . 305)\n  (:start . 300) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 306) (:start . 305)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x1109.2.1) (:span 40 54)))\n (:hscopes ((:id . :x1109.2.1) (:span 40 252)))\n (:identifiers (:sid . :s1109.2) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010328@unknown@formal@none@1@S@Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "major") (:form . 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",") (:end . 285) (:start . 284)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 294)\n  (:start . 286) (:id . 89))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 299) (:start . 295)\n  (:id . 90))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 308)\n  (:start . 300) (:id . 91))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 317)\n  (:start . 309) (:id . 92))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 319) (:start . 318)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "VCAM)-1") (:form . "VCAM)-1") (:end . 326)\n  (:start . 319) (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 330) (:start . 327)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 342)\n  (:start . 331) (:id . 96))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 352)\n  (:start . 343) (:id . 97))\n ((:tag . "NN") (:stem . "adhesion") (:form . 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5010330@unknown@formal@none@1@S@The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "elam-1") (:form . "ELAM-1") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MVEC") (:form . "MVEC") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 67)\n  (:start . 59) (:id . 55))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 74)\n  (:start . 68) (:id . 56))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 78) (:start . 77)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 91) (:start . 87)\n  (:id . 61))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 102)\n  (:start . 92) (:id . 62))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 117) (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 144) (:start . 130) (:id . 68))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 151)\n  (:start . 145) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1109.5) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010331@unknown@formal@none@1@S@PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.@(((:tag . "NN") (:stem . "pao") (:form . "PAO") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 71)\n  (:start . 61) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 79) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 84) (:start . 80)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 94)\n  (:start . 88) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 102) (:start . 98)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 112)\n  (:start . 103) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1109.6.1) (:span 61 71)))\n (:hscopes ((:id . :x1109.6.1) (:span 61 112)))\n (:identifiers (:sid . :s1109.6) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010332@unknown@formal@none@1@S@Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.@(((:tag . "IN") (:stem . "besides") (:form . "Besides") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PTPase") (:form . "PTPase") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "pervanadate") (:form . "pervanadate") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "diamide") (:form . "diamide") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "tnf-dependent") (:form . "TNF-dependent")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 124)\n  (:start . 114) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1109.7) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010333@unknown@formal@none@1@S@Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "attachment") (:form . "attachment") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "MVEC") (:form . "MVEC") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PTPase") (:form . "PTPase") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1109.8) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010334@unknown@formal@none@1@S@Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "overall") (:form . "overall") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 26)\n  (:start . 19) (:id . 47))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ptpase") (:form . "PTPase") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 149)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 163)\n  (:start . 155) (:id . 68))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 173)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1109.9.1) (:span 65 71 81 83)))\n (:hscopes ((:id . :x1109.9.1) (:span 65 94)))\n (:identifiers (:sid . :s1109.9) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010335@unknown@formal@none@1@S@Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 16)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PTPase") (:form . "PTPase") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 73)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 93)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 123)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 138) (:start . 125) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "metastasis") (:form . "metastasis") (:end . 160)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1109.10.1) (:span 47 50)))\n (:hscopes ((:id . :x1109.10.1) (:span 47 160)))\n (:identifiers (:sid . :s1109.10) (:did . :|9341756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010336@unknown@formal@none@1@S@The spatial distribution of human immunoglobulin genes within the nucleus: evidence for gene topography independent of cell type and transcriptional activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "spatial") (:form . "spatial") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "topography") (:form . "topography") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 115)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 128) (:start . 124)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 148) (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1110.1) (:did . :|9341877|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010337@unknown@formal@none@1@S@The three-dimensional positioning of immunoglobulin (Ig) genes within the nucleus of human cells was investigated using in situ hybridization and confocal microscopy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "three-dimensional") (:form . "three-dimensional")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "positioning") (:form . "positioning") (:end . 33)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 51) (:start . 37) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 119) (:start . 114)\n  (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "FW") (:stem . "situ") (:form . "situ") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hybridization") (:form . "hybridization")\n  (:end . 141) (:start . 128) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "confocal") (:form . "confocal") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 165)\n  (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1110.2) (:did . :|9341877|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010338@unknown@formal@none@1@S@The visualization of heavy and light chain genes in B-lymphoid cells showed that the three Ig genes are differentially and nonrandomly distributed in different nuclear subvolumes: the kappa genes were found to be preferentially confined to an outer nuclear volume, whereas the gamma and lambda genes consistently occupied more central positions within the nucleus, the lambda genes being more interior when compared with the gamma genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "visualization") (:form . "visualization")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "light") (:form . 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5010340@unknown@formal@none@1@S@Although subtle gene movements within those defined topographical regions cannot be excluded by this study, the results indicate that tissue specificity of gene expression is not accompanied by drastic changes in gene nuclear topography, rather suggesting that gene organization within the nucleus may be primarily dependent on structural constraints imposed on the respective chromosomes.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "subtle") (:form . "subtle") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "movement") (:form . "movements") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "those") (:form . 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5010341@unknown@formal@none@1@S@Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 113)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 122)\n  (:start . 114) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 128)\n  (:start . 123) (:id . 58))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1111.1) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010342@unknown@formal@none@1@S@Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells.@(((:tag . "NN") (:stem . "recruitment") (:form . "Recruitment") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "extravasation") (:form . "extravasation")\n  (:end . 29) (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "blood-brain") (:form . "blood-brain") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "barrier") (:form . "barrier") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "favor") (:form . "favored") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "molecule-mediated") (:form . "molecule-mediated")\n  (:end . 114) (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 127)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 142)\n  (:start . 131) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 144) (:start . 143)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 167)\n  (:start . 156) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 173)\n  (:start . 168) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1111.2) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010343@unknown@formal@none@1@S@Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T lymphocytes into various organs, we have looked for the profile of adhesion molecules expressed by HTLV-1-transformed T cells.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pathological") (:form . "pathological") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HTLV-1)-associated") (:form . "HTLV-1)-associated")\n  (:end . 93) (:start . 75) (:id . 55))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 122)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "htlv-1-infected") (:form . "HTLV-1-infected")\n  (:end . 141) (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 155)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 160) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 168)\n  (:start . 161) (:id . 65))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 175)\n  (:start . 169) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "look") (:form . "looked") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 207)\n  (:start . 200) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 219)\n  (:start . 211) (:id . 75))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 229)\n  (:start . 220) (:id . 76))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 239)\n  (:start . 230) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 242) (:start . 240)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "htlv-1-transformed") (:form . "HTLV-1-transformed")\n  (:end . 261) (:start . 243) (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 263) (:start . 262)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 269)\n  (:start . 264) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1111.3) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010344@unknown@formal@none@1@S@Flow cytometry analysis indicated that these cells were expressing high levels of vascular cell adhesion molecule 1 (VCAM-1 [CD106]), a 110-kDa member of the immunoglobulin gene superfamily, first identified on endothelial cells stimulated with inflammatory cytokines.@(((:tag . "NNP") (:stem . "Flow") (:form . "Flow") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CD106") (:form . "CD106") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "110-kda") (:form . "110-kDa") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 172) (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 177) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 189)\n  (:start . 178) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 196)\n  (:start . 191) (:id . 75))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 207)\n  (:start . 197) (:id . 76))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 210) (:start . 208)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 222)\n  (:start . 211) (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 228)\n  (:start . 223) (:id . 79))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 239)\n  (:start . 229) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 244) (:start . 240)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 257)\n  (:start . 245) (:id . 82))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 267)\n  (:start . 258) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1111.4.1) (:span 24 38)))\n (:hscopes ((:id . :x1111.4.1) (:span 24 267)))\n (:identifiers (:sid . :s1111.4) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010345@unknown@formal@none@1@S@This adhesion molecule was also expressed by T cells obtained from one patient with HTLV-1-associated myelopathy/tropical spastic paraparesis but not by activated T cells isolated from one normal blood donor.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "htlv-1-associated") (:form . "HTLV-1-associated")\n  (:end . 101) (:start . 84) (:id . 56))\n ((:tag . "JJ") (:stem . "myelopathy/tropical")\n  (:form . "myelopathy/tropical") (:end . 121) (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "spastic") (:form . "spastic") (:end . 129)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "paraparesis") (:form . "paraparesis") (:end . 141)\n  (:start . 130) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 145) (:start . 142)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 162)\n  (:start . 153) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 164) (:start . 163)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 179)\n  (:start . 171) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 188) (:start . 185)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 195)\n  (:start . 189) (:id . 69))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 201)\n  (:start . 196) (:id . 70))\n ((:tag . "NN") (:stem . "donor") (:form . "donor") (:end . 207)\n  (:start . 202) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1111.5.1) (:span 146 149)))\n (:nscopes ((:id . :x1111.5.1) (:span 146 207)))\n (:identifiers (:sid . :s1111.5) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010346@unknown@formal@none@1@S@The role of the viral trans-activator Tax protein in the induction of VCAM-1 was first indicated by the detection of this adhesion molecule on Jurkat T-cell clones stably expressing the tax gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 37) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 149)\n  (:start . 143) (:id . 66))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 163)\n  (:start . 157) (:id . 68))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1111.6) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010347@unknown@formal@none@1@S@The effect of Tax on VCAM-1 gene transcription was next confirmed in JPX-9 cells, a subclone of Jurkat cells, carrying the tax sequences under the control of an inducible promoter.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 46) (:start . 33) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "JPX-9") (:form . "JPX-9") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "subclone") (:form . "subclone") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 170)\n  (:start . 161) (:id . 72))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 179)\n  (:start . 171) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1111.7) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010348@unknown@formal@none@1@S@Furthermore, deletion and mutation analyses of the VCAM-1 promoter performed with chloramphenicol acetyltransferase constructs revealed that Tax was trans activating the VCAM-1 promoter via two NF-kappaB sites present at bp -72 and -57 in the VCAM-1 gene promoter, with both of them being required for the Tax-induced expression of this adhesion molecule.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . 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5010350@unknown@formal@none@1@S@Collectively, these results therefore suggest that the exclusive Tax-induced expression of VCAM-1 on T cells may represent a pivotal event in the progression of HTLV-1-associated diseases.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "tax-induced") (:form . "Tax-induced") (:end . 76)\n  (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 97)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 157)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "htlv-1-associated") (:form . "HTLV-1-associated")\n  (:end . 178) (:start . 161) (:id . 67))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 187)\n  (:start . 179) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1111.10.1) (:span 109 112))\n  ((:id . :x1111.10.2) (:span 38 45)))\n (:hscopes ((:id . :x1111.10.1) (:span 109 187))\n  ((:id . :x1111.10.2) (:span 38 187)))\n (:identifiers (:sid . :s1111.10) (:did . :|9343210|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010351@unknown@formal@none@1@S@Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.@(((:tag . "NN") (:stem . "blockade") (:form . "Blockade") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "dithiocarbamate") (:form . "dithiocarbamates")\n  (:end . 49) (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1112.1) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010352@unknown@formal@none@1@S@Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types.@(((:tag . "NNS") (:stem . "dithiocarbamate") (:form . "Dithiocarbamates")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DTC") (:form . "DTCs") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "powerful") (:form . "powerful") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1112.2) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010353@unknown@formal@none@1@S@Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 176)\n  (:start . 165) (:id . 67))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 182)\n  (:start . 177) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 199)\n  (:start . 187) (:id . 70))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 208)\n  (:start . 200) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1112.3.1) (:span 155 164))\n  ((:id . :x1112.3.2) (:span 142 151)))\n (:hscopes ((:id . :x1112.3.1) (:span 155 208))\n  ((:id . :x1112.3.2) (:span 111 208)))\n (:identifiers (:sid . :s1112.3) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010354@unknown@formal@none@1@S@We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DTC") (:form . "DTCs") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1112.4) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010355@unknown@formal@none@1@S@This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . 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5010356@unknown@formal@none@1@S@Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 28) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . 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5010357@unknown@formal@none@1@S@Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "target") (:form . "targeted") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 109) (:start . 94) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 147)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 156)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1112.7) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010358@unknown@formal@none@1@S@Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells.@(((:tag . "RB") (:stem . "strikingly") (:form . "Strikingly") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "immunocytochemical") (:form . "immunocytochemical")\n  (:end . 51) (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 63)\n  (:start . 52) (:id . 48))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 73)\n  (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 83) (:start . 79)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "shuttling") (:form . "shuttling") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFATp") (:form . "NFATp") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 143)\n  (:start . 138) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . "VBN") (:stem . "accelerate") (:form . "accelerated") (:end . 173)\n  (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "export") (:form . "export") (:end . 180)\n  (:start . 174) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 69))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 197)\n  (:start . 190) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 210)\n  (:start . 201) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1112.8.1) (:span 64 78)))\n (:hscopes ((:id . :x1112.8.1) (:span 64 218)))\n (:identifiers (:sid . :s1112.8) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010360@unknown@formal@none@1@S@In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-KB") (:form . "NF-KB") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "dtc") (:form . "DTCs") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "immunosuppressant") (:form . "immunosuppressants")\n  (:end . 116) (:start . 98) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1112.10.1) (:span 73 82)))\n (:hscopes ((:id . :x1112.10.1) (:span 73 116)))\n (:identifiers (:sid . :s1112.10) (:did . :|9343406|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010361@unknown@formal@none@1@S@Suppression of nuclear factor kappa B and CD18-mediated leukocyte adhesion to the corneal endothelium by dexamethasone.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd18-mediated") (:form . "CD18-mediated")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "corneal") (:form . "corneal") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 118) (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1113.1) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010362@unknown@formal@none@1@S@PURPOSE: To demonstrate that leukocyte adhesion to cultured corneal endothelial cells is mediated by the CD18 antigen, and to determine whether dexamethasone directly suppresses adhesion by inhibiting activation of nuclear factor kappa B (NFkappaB).@(((:tag . "NN") (:stem . "purpose") (:form . "PURPOSE") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "To") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "corneal") (:form . "corneal") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd18") (:form . "CD18") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 157) (:start . 144) (:id . 65))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 177)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 186)\n  (:start . 178) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 189) (:start . 187)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 200)\n  (:start . 190) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 211)\n  (:start . 201) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 222)\n  (:start . 215) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 229)\n  (:start . 223) (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 235)\n  (:start . 230) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 237) (:start . 236)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 239) (:start . 238)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 247)\n  (:start . 239) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1113.2.1) (:span 136 143)))\n (:hscopes ((:id . :x1113.2.1) (:span 136 248)))\n (:identifiers (:sid . :s1113.2) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010363@unknown@formal@none@1@S@METHODS: Cultured bovine corneal endothelium was stimulated for 6 hours by 40 micron/ml tumor necrosis factor alpha (TNFalpha).@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "culture") (:form . "Cultured") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "bovine") (:form . "bovine") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "corneal") (:form . "corneal") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "micron/ml") (:form . "micron/ml") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1113.3) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010364@unknown@formal@none@1@S@Dexamethasone was added 1 hour before TNFalpha stimulation in the dexamethasone group.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hour") (:form . "hour") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 79) (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1113.4) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010365@unknown@formal@none@1@S@After stimulation, neutrophils separated from a healthy human volunteer were added with or without anti-CD18 antibody.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "volunteer") (:form . "volunteer") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "JJ") (:stem . "anti-cd18") (:form . "anti-CD18") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1113.5.1) (:span 91 98)))\n (:nscopes ((:id . :x1113.5.1) (:span 91 117)))\n (:identifiers (:sid . :s1113.5) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010366@unknown@formal@none@1@S@The culture plate was settled for 15 minutes at 37 degrees C, and then neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine for 5 minutes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "plate") (:form . "plate") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "settle") (:form . "settled") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "degree") (:form . "degrees") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 70) (:start . 66)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 82)\n  (:start . 71) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 97)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "N-formyl-methionyl-leucyl-phenylalanine")\n  (:form . "N-formyl-methionyl-leucyl-phenylalanine") (:end . 140)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1113.6) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010367@unknown@formal@none@1@S@Nonadherent neutrophils were removed by sealing and inverting the culture well.@(((:tag . "JJ") (:stem . "nonadherent") (:form . "Nonadherent") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "seal") (:form . "sealing") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "invert") (:form . "inverting") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1113.7) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010368@unknown@formal@none@1@S@The intracellular localization of NFkappaB after TNFalpha simulation was determined by confocal immunocytochemistry using an anti-p65 antibody.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "simulation") (:form . "simulation") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 83)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "confocal") (:form . "confocal") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "immunocytochemistry")\n  (:form . "immunocytochemistry") (:end . 115) (:start . 96) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 121) (:start . 116)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 124) (:start . 122)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "anti-p65") (:form . "anti-p65") (:end . 133)\n  (:start . 125) (:id . 57))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 142)\n  (:start . 134) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1113.8) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010370@unknown@formal@none@1@S@This increased adhesion was suppressed by the addition of anti-CD18 antibody (157.6+/-25.1 cells/mm2, n = 8, P < 0.01) and by pretreatment with 10(-7) M dexamethasone (207.9+/-31.5 cells/mm2, n = 10, P < 0.01).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "anti-cd18") (:form . "anti-CD18") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "CD") (:stem . "157.6+/-25.1") (:form . "157.6+/-25.1") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "cells/mm2") (:form . "cells/mm2") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 138)\n  (:start . 126) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "10(-7)") (:form . "10(-7)") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 166) (:start . 153) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "CD") (:stem . "207.9+/-31.5") (:form . "207.9+/-31.5") (:end . 180)\n  (:start . 168) (:id . 73))\n ((:tag . "NNS") (:stem . "cells/mm2") (:form . "cells/mm2") (:end . 190)\n  (:start . 181) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 75))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 193) (:start . 192)\n  (:id . 76))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 195) (:start . 194)\n  (:id . 77))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 198) (:start . 196)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 79))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 201) (:start . 200)\n  (:id . 80))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 203) (:start . 202)\n  (:id . 81))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 208) (:start . 204)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1113.10) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010371@unknown@formal@none@1@S@Immunocytochemistry 60 minutes after stimulation revealed that NFkappaB was located in the cytoplasm in unstimulated cells; however, the addition of TNFalpha caused NFkappaB to translocate into the nucleus.@(((:tag . "NNP") (:stem . "Immunocytochemistry")\n  (:form . "Immunocytochemistry") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 22) (:start . 20)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 48)\n  (:start . 37) (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 57)\n  (:start . 49) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 71)\n  (:start . 63) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 83)\n  (:start . 76) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 116)\n  (:start . 104) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 123) (:start . 122)\n  (:id . 58))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 131)\n  (:start . 124) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 145)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 164)\n  (:start . 158) (:id . 65))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 173)\n  (:start . 165) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "VB") (:stem . "translocate") (:form . "translocate") (:end . 188)\n  (:start . 177) (:id . 68))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 193) (:start . 189)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 205)\n  (:start . 198) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1113.11) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010372@unknown@formal@none@1@S@Pretreatment with dexamethasone tapered NFkappaB translocation into the nucleus.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 31) (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "taper") (:form . "tapered") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "nfkappab") (:form . "NFkappaB") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 62) (:start . 49) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 67) (:start . 63)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 79)\n  (:start . 72) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1113.12) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010373@unknown@formal@none@1@S@CONCLUSIONS: Leukocyte adhesion to the corneal endothelium was shown to be mediated by CD18 expressed on activated leukocytes.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Leukocyte") (:form . "Leukocyte") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "corneal") (:form . "corneal") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd18") (:form . "CD18") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1113.13) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010374@unknown@formal@none@1@S@Pretreatment of the endothelium with dexamethasone inhibited leukocyte adhesion; this may be due in part to the suppression of NFkappaB entry into the nucleus.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 50) (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 60)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 79)\n  (:start . 71) (:id . 50))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1113.14.1) (:span 86 89)))\n (:hscopes ((:id . :x1113.14.1) (:span 86 158)))\n (:identifiers (:sid . :s1113.14) (:did . :|9344365|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010375@unknown@formal@none@1@S@Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB [see comments]@(((:tag . "NNP") (:stem . "Helenalin") (:form . "Helenalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 31) (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "sesquiterpene") (:form . "sesquiterpene")\n  (:end . 45) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "lactone") (:form . "lactone") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Arnica") (:form . "Arnica") (:end . 65)\n  (:start . 59) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 87)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 108)\n  (:start . 102) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 118)\n  (:start . 109) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 120) (:start . 119)\n  (:id . 56))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 123) (:start . 120)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 133) (:start . 132)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1114.1) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010376@unknown@formal@none@1@S@Alcoholic extracts prepared form Arnicae flos, the collective name for flowerheads from Arnica montana and A. chamissonis ssp. foliosa, are used therapeutically as anti-inflammatory remedies.@(((:tag . "JJ") (:stem . "alcoholic") (:form . "Alcoholic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "FW") (:stem . "arnicae") (:form . "Arnicae") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "FW") (:stem . "flos") (:form . "flos") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "collective") (:form . "collective") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "name") (:form . "name") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "flowerhead") (:form . "flowerheads") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Arnica") (:form . "Arnica") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "montana") (:form . "montana") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "a.") (:form . "A.") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chamissonis") (:form . "chamissonis") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "ssp.") (:form . "ssp.") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "foliosa") (:form . "foliosa") (:end . 134)\n  (:start . 127) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . "RB") (:stem . "therapeutically") (:form . "therapeutically")\n  (:end . 160) (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 181) (:start . 164) (:id . 67))\n ((:tag . "NNS") (:stem . "remedy") (:form . "remedies") (:end . 190)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1114.2) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010377@unknown@formal@none@1@S@The active ingredients mediating the pharmacological effect are mainly sesquiterpene lactones, such as helenalin, 11alpha,13-dihydrohelenalin, chamissonolid and their ester derivatives.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "ingredient") (:form . "ingredients") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pharmacological") (:form . "pharmacological")\n  (:end . 52) (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "sesquiterpene") (:form . "sesquiterpene")\n  (:end . 84) (:start . 71) (:id . 51))\n ((:tag . "NNS") (:stem . "lactone") (:form . "lactones") (:end . 93)\n  (:start . 85) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 99) (:start . 95)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "helenalin") (:form . "helenalin") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "NN") (:stem . "11alpha,13-dihydrohelenalin")\n  (:form . "11alpha,13-dihydrohelenalin") (:end . 141) (:start . 114)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "NN") (:stem . "chamissonolid") (:form . "chamissonolid")\n  (:end . 156) (:start . 143) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 166)\n  (:start . 161) (:id . 62))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 172)\n  (:start . 167) (:id . 63))\n ((:tag . "NNS") (:stem . "derivative") (:form . "derivatives") (:end . 184)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1114.3) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010378@unknown@formal@none@1@S@While these compounds affect various cellular processes, current data do not fully explain how sesquiterpene lactones exert their anti-inflammatory effect.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "affect") (:form . "affect") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sesquiterpene") (:form . "sesquiterpene")\n  (:end . 108) (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "lactone") (:form . "lactones") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "VBP") (:stem . "exert") (:form . "exert") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 147) (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 154)\n  (:start . 148) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1114.4) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010380@unknown@formal@none@1@S@This difference in efficacy, which correlates with the compounds' anti-inflammatory potency in vivo, may be explained by differences in structure and conformation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 83) (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 132)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 162)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1114.6.1) (:span 101 104)))\n (:hscopes ((:id . :x1114.6.1) (:span 0 162)))\n (:identifiers (:sid . :s1114.6) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010381@unknown@formal@none@1@S@NF-kappaB, which resides in an inactive, cytoplasmic complex in unstimulated cells, is activated by phosphorylation and degradation of its inhibitory subunit, IkappaB.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "reside") (:form . "resides") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 115) (:start . 100) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 131)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 166)\n  (:start . 159) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1114.7) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010382@unknown@formal@none@1@S@Helenalin inhibits NF-kappaB activation in response to four different stimuli in T-cells, B-cells and epithelial cells and abrogates kappaB-driven gene expression.@(((:tag . "NNP") (:stem . "Helenalin") (:form . "Helenalin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 51)\n  (:start . 43) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 88)\n  (:start . 81) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B-cell") (:form . "B-cells") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "abrogate") (:form . "abrogates") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "JJ") (:stem . "kappab-driven") (:form . "kappaB-driven")\n  (:end . 146) (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1114.8) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010383@unknown@formal@none@1@S@This inhibition is selective, as the activity of four other transcription factors, Oct-1, TBP, Sp1 and STAT 5 was not affected.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 126)\n  (:start . 118) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1114.9.1) (:span 114 117)))\n (:nscopes ((:id . :x1114.9.1) (:span 33 126)))\n (:identifiers (:sid . :s1114.9) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010384@unknown@formal@none@1@S@We show that inhibition is not due to a direct modification of the active NF-kappaB heterodimer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 46)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 59)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 73)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1114.10.1) (:span 27 30)))\n (:nscopes ((:id . :x1114.10.1) (:span 27 95)))\n (:identifiers (:sid . :s1114.10) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010385@unknown@formal@none@1@S@Rather, helenalin modifies the NF-kappaB/IkappaB complex, preventing the release of IkappaB.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "helenalin") (:form . "helenalin") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "modify") (:form . "modifies") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB/IkappaB") (:form . "NF-kappaB/IkappaB")\n  (:end . 48) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1114.11) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010386@unknown@formal@none@1@S@These data suggest a molecular mechanism for the anti-inflammatory effect of sesquiterpene lactones, which differs from that of other nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and acetyl salicylic acid.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 66) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sesquiterpene") (:form . "sesquiterpene")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "lactone") (:form . "lactones") (:end . 99)\n  (:start . 91) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "JJ") (:stem . "nonsteroidal") (:form . "nonsteroidal") (:end . 146)\n  (:start . 134) (:id . 62))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 164) (:start . 147) (:id . 63))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 170)\n  (:start . 165) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NSAID") (:form . "NSAIDs") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "indomethacin") (:form . "indomethacin") (:end . 193)\n  (:start . 181) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 204)\n  (:start . 198) (:id . 71))\n ((:tag . "JJ") (:stem . "salicylic") (:form . "salicylic") (:end . 214)\n  (:start . 205) (:id . 72))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 219) (:start . 215)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1114.12.1) (:span 11 18)))\n (:hscopes ((:id . :x1114.12.1) (:span 11 219)))\n (:identifiers (:sid . :s1114.12) (:did . :|9348104|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010387@unknown@formal@none@1@S@Involvement of different transduction pathways in NF-kappa B activation by several inducers.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 82)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1115.1) (:did . :|9350434|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010388@unknown@formal@none@1@S@Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).@(((:tag . "NN") (:stem . "double-stimulation") (:form . "Double-stimulation")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 27) (:start . 23)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . 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5010390@unknown@formal@none@1@S@Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein.@(((:tag . "NN") (:stem . "dysregulation") (:form . "Dysregulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 47)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "low-density") (:form . "low-density") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "lipoprotein") (:form . "lipoprotein") (:end . 85)\n  (:start . 74) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1116.1) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010391@unknown@formal@none@1@S@Nuclear factor-kappa B (NF-kappa B)/Rel transcription factors may be involved in atherosclerosis, as is suggested by the presence of activated NF-kappa B in human atherosclerotic lesions.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "B)/Rel") (:form . "B)/Rel") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 96) (:start . 81) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 142)\n  (:start . 133) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "JJ") (:stem . "atherosclerotic") (:form . "atherosclerotic")\n  (:end . 178) (:start . 163) (:id . 68))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 186)\n  (:start . 179) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1116.2.1) (:span 104 113))\n  ((:id . :x1116.2.2) (:span 62 65)))\n (:hscopes ((:id . :x1116.2.1) (:span 101 186))\n  ((:id . :x1116.2.2) (:span 0 96)))\n (:identifiers (:sid . :s1116.2) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010392@unknown@formal@none@1@S@The aim of the present study was to investigate the effects of oxidized LDL (oxLDL) on the NF-kappa B system in human THP-1 monocytic cells as well as adherent monocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 47)\n  (:start . 36) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NNP") (:stem . "LDL") (:form . "LDL") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "oxldl") (:form . "oxLDL") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 108)\n  (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 65))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 123)\n  (:start . 118) (:id . 66))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 133)\n  (:start . 124) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 68))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 69))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 147) (:start . 143)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 159)\n  (:start . 151) (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 169)\n  (:start . 160) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1116.3) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010393@unknown@formal@none@1@S@Our results demonstrate that short-term incubation of these cells with oxLDL activated p50/p65 containing NF-kappa B dimers and induced the expression of the target gene IL-8.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "short-term") (:form . "short-term") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "oxldl") (:form . "oxLDL") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "p50/p65") (:form . "p50/p65") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 105)\n  (:start . 95) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 123)\n  (:start . 117) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 164)\n  (:start . 158) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 169) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1116.4) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010394@unknown@formal@none@1@S@This activation of NF-kappa B was inhibited by the antioxidant and H2O2 scavenger pyrrolidine dithiocarbamate and the proteasome inhibitor PSI.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 109) (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 128)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 138)\n  (:start . 129) (:id . 60))\n ((:tag . "NNP") (:stem . "PSI") (:form . "PSI") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1116.5) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010395@unknown@formal@none@1@S@The oxLDL-induced NF-kappa B activation was accompanied by an initial depletion of I kappa B-alpha followed by a slight transient increase in the level of this inhibitor protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "oxldl-induced") (:form . "oxLDL-induced")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "slight") (:form . "slight") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 169)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1116.6) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010396@unknown@formal@none@1@S@In contrast, long-term treatment with oxLDL prevented the lipopolysaccharide-induced depletion of I kappa B-alpha, accompanied by an inhibition of both NF-kappa B activation and the expression of tumor necrosis factor-alpha and interleukin-1 beta genes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oxldl") (:form . "oxLDL") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lipopolysaccharide-induced")\n  (:form . "lipopolysaccharide-induced") (:end . 84) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 99) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 126)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 143)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 151) (:start . 147)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 160)\n  (:start . 152) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 192)\n  (:start . 182) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 201)\n  (:start . 196) (:id . 71))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 210)\n  (:start . 202) (:id . 72))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 223)\n  (:start . 211) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 227) (:start . 224)\n  (:id . 74))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 241) (:start . 228) (:id . 75))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 246) (:start . 242)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 252)\n  (:start . 247) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1116.7) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010397@unknown@formal@none@1@S@These observations provide additional evidence that oxLDL is a potent modulator of gene expression and suggest that (dys)regulation of NF-kappa B/Rel is likely to play an important role in atherogenesis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oxldl") (:form . "oxLDL") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "modulator") (:form . "modulator") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dys)regulation") (:form . "dys)regulation")\n  (:end . 131) (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 180)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 202) (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1116.8.1) (:span 153 159))\n  ((:id . :x1116.8.2) (:span 103 110)))\n (:hscopes ((:id . :x1116.8.1) (:span 116 202))\n  ((:id . :x1116.8.2) (:span 103 202)))\n (:identifiers (:sid . :s1116.8) (:did . :|9351352|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010398@unknown@formal@none@1@S@Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 72) (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1117.1.1) (:span 84 91)))\n (:nscopes ((:id . :x1117.1.1) (:span 84 113)))\n (:identifiers (:sid . :s1117.1) (:did . :|9352360|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010400@unknown@formal@none@1@S@We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a mutant protein with potent suppressive properties for MHC class II expression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "CD") (:stem . "151") (:form . "151") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "encompass") (:form . "encompassing") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "acidic") (:form . "acidic") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "leave") (:form . "leaving") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "proline/serine/threonine-rich")\n  (:form . "proline/serine/threonine-rich") (:end . 148) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 164)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 184)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 189) (:start . 185)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 196)\n  (:start . 190) (:id . 72))\n ((:tag . "JJ") (:stem . "suppressive") (:form . "suppressive") (:end . 208)\n  (:start . 197) (:id . 73))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 219)\n  (:start . 209) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 223) (:start . 220)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 227) (:start . 224)\n  (:id . 76))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 233)\n  (:start . 228) (:id . 77))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 236) (:start . 234)\n  (:id . 78))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 247)\n  (:start . 237) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1117.3) (:did . :|9352360|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010401@unknown@formal@none@1@S@HeLa cells stably or transiently transfected with mutant CIITA constructs showed up to 99% suppression of MHC class II antigen induction by IFN-gamma and marked suppression of HLA-DRA mRNA expression.@(((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 80) (:start . 74)\n  (:id . 52))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "CD") (:stem . "99") (:form . "99") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 160)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 172)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1117.4) (:did . :|9352360|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010402@unknown@formal@none@1@S@Transient transfection of a B lymphoma line resulted in up to 89% reduction of constitutive MHC class II expression within 5 days and suppression of HLA-DRA mRNA synthesis.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "CD") (:stem . "89") (:form . "89") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "NNP") (:stem . "MHC") (:form . "MHC") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 145)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HLA-DRA") (:form . "HLA-DRA") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 171)\n  (:start . 162) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1117.5) (:did . :|9352360|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010403@unknown@formal@none@1@S@CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.@(((:tag . "JJ") (:stem . "cd30-dependent") (:form . "CD30-dependent")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 26)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1118.1) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010404@unknown@formal@none@1@S@CD30 is a cell-surface receptor that can augment lymphocyte activation and survival through its ability to induce the transcription factor NF-kappaB.@(((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cell-surface") (:form . "cell-surface") (:end . 22)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1118.2) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010405@unknown@formal@none@1@S@CD30, however, has also been implicated in the induction of apoptotic cell death of lymphocytes.@(((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 39)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 95)\n  (:start . 84) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1118.3) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010406@unknown@formal@none@1@S@Here we show that one of the effects of CD30 signal transduction is to render cells sensitive to apoptosis induced by the type 1 tumor necrosis factor receptor (TNFR1).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 51)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 64)\n  (:start . 52) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "VB") (:stem . "render") (:form . "render") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNFR1") (:form . "TNFR1") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1118.4) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010407@unknown@formal@none@1@S@This sensitization is dependent on the TRAF-binding sites within the CD30 cytoplasmic domain.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sensitization") (:form . "sensitization")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "traf-binding") (:form . "TRAF-binding") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1118.5) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010408@unknown@formal@none@1@S@One of the proteins that binds to these sites is TRAF2, a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 64)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 77)\n  (:start . 65) (:id . 56))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tnfr1") (:form . "TNFR1") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 143)\n  (:start . 133) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 165)\n  (:start . 155) (:id . 70))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 173)\n  (:start . 166) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 73))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 199)\n  (:start . 192) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1118.6) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010410@unknown@formal@none@1@S@These data suggest a model in which CD30 limits its own ability to transduce cell survival signals through signal-coupled depletion of TRAF2.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "limit") (:form . "limits") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VB") (:stem . "transduce") (:form . "transduce") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "JJ") (:stem . "signal-coupled") (:form . "signal-coupled")\n  (:end . 121) (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1118.8.1) (:span 11 18)))\n (:hscopes ((:id . :x1118.8.1) (:span 11 140)))\n (:identifiers (:sid . :s1118.8) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010411@unknown@formal@none@1@S@Depletion of intracellular TRAF2 and its coassociated proteins also increased the sensitivity of the cell to undergoing apoptosis during activation of death-inducing receptors such as TNFR1.@(((:tag . "NN") (:stem . "depletion") (:form . "Depletion") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "coassociate") (:form . "coassociated") (:end . 53)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 93)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "undergo") (:form . "undergoing") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 136)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "death-inducing") (:form . "death-inducing")\n  (:end . 165) (:start . 151) (:id . 63))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 175)\n  (:start . 166) (:id . 64))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 180) (:start . 176)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 183) (:start . 181)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TNFR1") (:form . "TNFR1") (:end . 189)\n  (:start . 184) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1118.9) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010412@unknown@formal@none@1@S@Consistent with this hypothesis, expression of a dominant-negative form of TRAF2 was found to potentiate TNFR1-mediated death.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 66) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "VB") (:stem . "potentiate") (:form . "potentiate") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "tnfr1-mediated") (:form . "TNFR1-mediated")\n  (:end . 119) (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1118.10) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010413@unknown@formal@none@1@S@These studies provide a potential mechanism through which CD30, as well as other TRAF-binding members of the TNFR superfamily, can negatively regulate cell survival.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "traf-binding") (:form . "TRAF-binding") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNFR") (:form . "TNFR") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 141)\n  (:start . 131) (:id . 64))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1118.11.1) (:span 24 33)))\n (:hscopes ((:id . :x1118.11.1) (:span 24 164)))\n (:identifiers (:sid . :s1118.11) (:did . :|9353251|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010414@unknown@formal@none@1@S@TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.@(((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "cooperate") (:form . "cooperates") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . "JJ") (:stem . "tre-like") (:form . "TRE-like") (:end . 129)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 143)\n  (:start . 135) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1119.1) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010415@unknown@formal@none@1@S@Activating protein-1 (AP-1) binding TPA responsive elements (TRE) are located downstream of the transcription initiation site in the U5 region of the HIV-1 long terminal repeat (LTR).@(((:tag . "VBG") (:stem . "activate") (:form . "Activating") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "TPA") (:form . "TPA") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "u5") (:form . "U5") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 169)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 176)\n  (:start . 170) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1119.2) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010416@unknown@formal@none@1@S@These downstream sequence elements, termed DSE, can bind both AP-1 and CREB/ATF transcription factors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 42) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1119.3) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010417@unknown@formal@none@1@S@Recently, we demonstrated that the DSE are also cAMP-responsive elements (CRE), since they mediated activation signals elicited by cholera toxin (Ctx), a potent activator of the cAMP-dependent protein kinase A (PKA) signal transduction pathway.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "camp-responsive") (:form . "cAMP-responsive")\n  (:end . 63) (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cholera") (:form . "cholera") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Ctx") (:form . "Ctx") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 170)\n  (:start . 161) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "camp-dependent") (:form . "cAMP-dependent")\n  (:end . 192) (:start . 178) (:id . 75))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 200)\n  (:start . 193) (:id . 76))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 207)\n  (:start . 201) (:id . 77))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 209) (:start . 208)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "PKA") (:form . "PKA") (:end . 214) (:start . 211)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 81))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 222)\n  (:start . 216) (:id . 82))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 235)\n  (:start . 223) (:id . 83))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 243)\n  (:start . 236) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1119.4) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010418@unknown@formal@none@1@S@In the present study, we demonstrate that the HIV-1 DSE can mediate the transcriptional synergy elicited by the combination of Ctx and TNFalpha.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 36)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 87) (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 123)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Ctx") (:form . "Ctx") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1119.5) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010420@unknown@formal@none@1@S@Transfection studies of LTR reporter constructs indicated that mutation of the DSE sites abrogated the LTR-mediated synergy induced by Ctx and TNFalpha, whereas the synergy induced by Ctx and IL-1beta was unaffected, suggesting TNFalpha and IL-1beta cooperate differently with the cAMP/PKA activation pathway to induce HIV-1 expression in U1 cells.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 71)\n  (:start . 63) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dse") (:form . "DSE") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "ltr-mediated") (:form . "LTR-mediated") (:end . 115)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "synergy") (:form . 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"induced") (:end . 180)\n  (:start . 173) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Ctx") (:form . "Ctx") (:end . 187) (:start . 184)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 215)\n  (:start . 205) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 227)\n  (:start . 217) (:id . 76))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 236)\n  (:start . 228) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 249)\n  (:start . 241) (:id . 79))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 259)\n  (:start . 250) (:id . 80))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 271)\n  (:start . 260) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 276) (:start . 272)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 280) (:start . 277)\n  (:id . 83))\n ((:tag . "NN") (:stem . "camp/pka") (:form . "cAMP/PKA") (:end . 289)\n  (:start . 281) (:id . 84))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 300)\n  (:start . 290) (:id . 85))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 308)\n  (:start . 301) (:id . 86))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 311) (:start . 309)\n  (:id . 87))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 318)\n  (:start . 312) (:id . 88))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 324)\n  (:start . 319) (:id . 89))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 335)\n  (:start . 325) (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 338) (:start . 336)\n  (:id . 91))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 341) (:start . 339)\n  (:id . 92))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 347)\n  (:start . 342) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 348) (:start . 347)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x1119.7.1) (:span 217 227)))\n (:hscopes ((:id . :x1119.7.1) (:span 217 347)))\n (:identifiers (:sid . :s1119.7) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010421@unknown@formal@none@1@S@Because the DSE are also TRE sites, we assessed the effect of the agonist combinations on AP-1-dependent transcription.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tre") (:form . "TRE") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "assess") (:form . "assessed") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 73)\n  (:start . 66) (:id . 56))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 86)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ap-1-dependent") (:form . "AP-1-dependent")\n  (:end . 104) (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1119.8) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010422@unknown@formal@none@1@S@TNFalpha as well as IL-1beta cooperated with Ctx to produce a synergistic activation of AP-1-mediated transcription.@(((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "cooperate") (:form . "cooperated") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ctx") (:form . "Ctx") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ap-1-mediated") (:form . "AP-1-mediated")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1119.9) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010423@unknown@formal@none@1@S@These data indicate that the TRE-like cAMP-responsive DSE sites within the 5'-untranslated leader can mediate the transcriptional cooperativity between TNFalpha and the cAMP/PKA pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "tre-like") (:form . "TRE-like") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "camp-responsive") (:form . "cAMP-responsive")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "dse") (:form . "DSE") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 90) (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "leader") (:form . "leader") (:end . 97)\n  (:start . 91) (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 109)\n  (:start . 102) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 129) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "cooperativity") (:form . "cooperativity")\n  (:end . 143) (:start . 130) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 151)\n  (:start . 144) (:id . 60))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 160)\n  (:start . 152) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 63))\n ((:tag . "NN") (:stem . "camp/pka") (:form . "cAMP/PKA") (:end . 177)\n  (:start . 169) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 185)\n  (:start . 178) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1119.10.1) (:span 11 24)))\n (:hscopes ((:id . :x1119.10.1) (:span 11 185)))\n (:identifiers (:sid . :s1119.10) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010424@unknown@formal@none@1@S@Since the DSE and TRE sites cannot bind CREB/ATF homodimers, we propose a mechanism in which the HIV-1 DSE bind heterodimers composed of both AP-1 and CREB/ATF proteins.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TRE") (:form . "TRE") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cannot") (:form . "cannot") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "creb/atf") (:form . "CREB/ATF") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 102)\n  (:start . 97) (:id . 60))\n ((:tag . "NNP") (:stem . "DSE") (:form . "DSE") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 124)\n  (:start . 112) (:id . 63))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "creb/atf") (:form . "CREB/ATF") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1119.11.1) (:span 64 71)))\n (:ncues ((:id . :x1119.11.2) (:span 28 34)))\n (:hscopes ((:id . :x1119.11.1) (:span 64 168)))\n (:nscopes ((:id . :x1119.11.2) (:span 28 59)))\n (:identifiers (:sid . :s1119.11) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010425@unknown@formal@none@1@S@Copyright 1997 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1997") (:form . "1997") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1119.12) (:did . :|9356353|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010426@unknown@formal@none@1@S@The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "engage") (:form . "engages") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 119) (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 125)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 132)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 60))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 151)\n  (:start . 144) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 164)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 171)\n  (:start . 165) (:id . 64))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 186) (:start . 172) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 199)\n  (:start . 191) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 209)\n  (:start . 200) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1120.1) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010427@unknown@formal@none@1@S@The Epstein-Barr virus latent membrane protein 1 (LMP1) is essential for the transformation of B lymphocytes into lymphoblastoid cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 91) (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 128) (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 139)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1120.2) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010428@unknown@formal@none@1@S@Previous data are consistent with a model that LMP1 is a constitutively activated receptor that transduces signals for transformation through its carboxyl-terminal cytoplasmic tail.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 71) (:start . 57) (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "transduce") (:form . "transduces") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 133) (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 163) (:start . 146) (:id . 63))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 175)\n  (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 180) (:start . 176)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1120.3) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010430@unknown@formal@none@1@S@Signals from TES1 are sufficient to drive initial proliferation of infected resting B lymphocytes, but most lymphoblastoid cells infected with a virus that does not express the 155 residues beyond TES1 fail to grow as long-term cell lines.@(((:tag . "NNS") (:stem . "signal") (:form . "Signals") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TES1") (:form . "TES1") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 122) (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "CD") (:stem . "155") (:form . "155") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "beyond") (:form . "beyond") (:end . 196)\n  (:start . 190) (:id . 72))\n ((:tag . "NNP") (:stem . "TES1") (:form . "TES1") (:end . 201) (:start . 197)\n  (:id . 73))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 206) (:start . 202)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 75))\n ((:tag . "VB") (:stem . "grow") (:form . "grow") (:end . 214) (:start . 210)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 217) (:start . 215)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 227)\n  (:start . 218) (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 238)\n  (:start . 233) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1120.5.1) (:span 202 206))\n  ((:id . :x1120.5.2) (:span 161 164)))\n (:nscopes ((:id . :x1120.5.1) (:span 202 238))\n  ((:id . :x1120.5.2) (:span 161 201)))\n (:identifiers (:sid . :s1120.5) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010431@unknown@formal@none@1@S@We now find that mutating two tyrosines to an isoleucine at the carboxyl end of the cytoplasmic tail cripples the ability of EBV to cause lymphoblastoid cell outgrowth, thereby marking a second transformation effector site, TES2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "mutate") (:form . "mutating") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "tyrosine") (:form . "tyrosines") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "isoleucine") (:form . "isoleucine") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "carboxyl") (:form . "carboxyl") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 95)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "cripple") (:form . "cripples") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 152) (:start . 138) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 167)\n  (:start . 158) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 176)\n  (:start . 169) (:id . 71))\n ((:tag . "VBG") (:stem . "mark") (:form . "marking") (:end . 184)\n  (:start . 177) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 193)\n  (:start . 187) (:id . 74))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 208) (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 217)\n  (:start . 209) (:id . 76))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 222) (:start . 218)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "TES2") (:form . "TES2") (:end . 228) (:start . 224)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1120.6) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010432@unknown@formal@none@1@S@A yeast two-hybrid screen identified TES2 interacting proteins, including the tumor necrosis factor receptor-associated death domain protein (TRADD).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "tes2") (:form . "TES2") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interacting") (:form . "interacting") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 119) (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 125)\n  (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 132)\n  (:start . 126) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1120.7) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010433@unknown@formal@none@1@S@TRADD was the only protein that interacted with wild-type TES2 and not with isoleucine-mutated TES2.@(((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "tes2") (:form . "TES2") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "isoleucine-mutated") (:form . "isoleucine-mutated")\n  (:end . 94) (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "tes2") (:form . "TES2") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1120.8.1) (:span 67 70)))\n (:nscopes ((:id . :x1120.8.1) (:span 67 99)))\n (:identifiers (:sid . :s1120.8) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010434@unknown@formal@none@1@S@TRADD associated with wild-type LMP1 but not with isoleucine-mutated LMP1 in mammalian cells, and TRADD constitutively associated with LMP1 in EBV-transformed cells.@(((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "isoleucine-mutated") (:form . "isoleucine-mutated")\n  (:end . 68) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tradd") (:form . "TRADD") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 118) (:start . 104) (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 129)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 158) (:start . 143) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1120.9.1) (:span 41 44)))\n (:nscopes ((:id . :x1120.9.1) (:span 41 92)))\n (:identifiers (:sid . :s1120.9) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010435@unknown@formal@none@1@S@In transfection assays, TRADD and TES2 synergistically mediated high-level NF-kappaB activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TES2") (:form . "TES2") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 54) (:start . 39) (:id . 49))\n ((:tag . "VBD") (:stem . "mediate") (:form . "mediated") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "high-level") (:form . "high-level") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1120.10) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010436@unknown@formal@none@1@S@These results indicate that LMP1 appropriates TRADD to enable efficient long-term lymphoblastoid cell outgrowth.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "appropriate") (:form . "appropriates") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "tradd") (:form . "TRADD") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VB") (:stem . "enable") (:form . "enable") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 96) (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 111)\n  (:start . 102) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x1120.11.1) (:span 14 27)))\n (:hscopes ((:id . :x1120.11.1) (:span 14 111)))\n (:identifiers (:sid . :s1120.11) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010437@unknown@formal@none@1@S@High-level NF-kappaB activation also appears to be a critical component of long-term outgrowth.@(((:tag . "JJ") (:stem . "high-level") (:form . "High-level") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1120.12.1) (:span 37 44)))\n (:hscopes ((:id . :x1120.12.1) (:span 0 94)))\n (:identifiers (:sid . :s1120.12) (:did . :|9356494|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010438@unknown@formal@none@1@S@Switching gears during T-cell maturation: RANTES and late transcription.@(((:tag . "VBG") (:stem . "switch") (:form . "Switching") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "gear") (:form . "gears") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rantes") (:form . "RANTES") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1121.1) (:did . :|9357137|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010440@unknown@formal@none@1@S@A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "VB") (:stem . "yield") (:form . "yield") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 144)\n  (:start . 133) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immunotherapeutic") (:form . "immunotherapeutic")\n  (:end . 170) (:start . 153) (:id . 64))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 178)\n  (:start . 171) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1121.3.1) (:span 98 101)))\n (:hscopes ((:id . :x1121.3.1) (:span 98 178)))\n (:identifiers (:sid . :s1121.3) (:did . :|9357137|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010441@unknown@formal@none@1@S@Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 30)\n  (:start . 21) (:id . 44))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 50)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 56) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 85)\n  (:start . 76) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 99)\n  (:start . 88) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1122.1) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010442@unknown@formal@none@1@S@The POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "POU") (:form . "POU") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "octamer-dependent") (:form . "octamer-dependent")\n  (:end . 88) (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "direct") (:form . "direct") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 146) (:start . 142)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "rearrange") (:form . "rearranged") (:end . 157)\n  (:start . 147) (:id . 62))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 172) (:start . 158) (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 178)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1122.2) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010443@unknown@formal@none@1@S@Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS).@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 37) (:start . 23) (:id . 47))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "restrict") (:form . "restricted") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 180)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 195)\n  (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 214) (:start . 196) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 216) (:start . 215)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1122.3) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010444@unknown@formal@none@1@S@However, the precise factors that mediate this induction mechanism remain unknown.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x1122.4.1) (:span 74 81)))\n (:hscopes ((:id . :x1122.4.1) (:span 9 81)))\n (:identifiers (:sid . :s1122.4) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010445@unknown@formal@none@1@S@In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "monitor") (:form . "monitored") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "arrest") (:form . "arrested") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "lps-responsive") (:form . "LPS-responsive")\n  (:end . 120) (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1122.5) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010446@unknown@formal@none@1@S@Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 181)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "oct-2-directed") (:form . "Oct-2-directed")\n  (:end . 199) (:start . 185) (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 213) (:start . 200) (:id . 74))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 216) (:start . 214)\n  (:id . 75))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 221) (:start . 217)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1122.6) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010447@unknown@formal@none@1@S@This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Oct-1") (:form . "Oct-1") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 159)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1122.7) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010448@unknown@formal@none@1@S@The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBZ") (:stem . "highlight") (:form . "highlights") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "cross-talk") (:form . "cross-talk") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 147)\n  (:start . 139) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 161)\n  (:start . 153) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 163) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 174)\n  (:start . 164) (:id . 64))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 183)\n  (:start . 175) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1122.8) (:did . :|9360945|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010450@unknown@formal@none@1@S@The Wilms' tumor suppressor gene ( WT1 ) was previously identified as being imprinted, with frequent maternal expression in human placentae and fetal brains.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "Wilms") (:form . "Wilms") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "WT1") (:form . "WT1") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 55)\n  (:start . 45) (:id . 52))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "imprint") (:form . "imprinted") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "JJ") (:stem . "maternal") (:form . "maternal") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "placentae") (:form . "placentae") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . "NNS") (:stem . "brain") (:form . "brains") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1123.2) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010451@unknown@formal@none@1@S@We examined the allele-specific expression of WT1 in cultured human fibroblasts from 15 individuals.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "allele-specific") (:form . "allele-specific")\n  (:end . 31) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wt1") (:form . "WT1") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1123.3) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010452@unknown@formal@none@1@S@Seven of 15 fibroblast lines were heterozygous for polymorphic alleles, and the expression patterns were variable, i.e., equal, unequal or monoallelic paternal expression in three, two and two cases, respectively.@(((:tag . "CD") (:stem . "seven") (:form . "Seven") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fibroblast") (:form . "fibroblast") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "polymorphic") (:form . "polymorphic") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unequal") (:form . "unequal") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "monoallelic") (:form . "monoallelic") (:end . 150)\n  (:start . 139) (:id . 66))\n ((:tag . "JJ") (:stem . "paternal") (:form . "paternal") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 179)\n  (:start . 174) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 192) (:start . 189)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 198)\n  (:start . 193) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 212)\n  (:start . 200) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1123.4) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010453@unknown@formal@none@1@S@Exclusive paternal expression of WT1 was also shown in non-cultured peripheral lymphocytes from the latter two individuals.@(((:tag . "JJ") (:stem . "exclusive") (:form . "Exclusive") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "paternal") (:form . "paternal") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "WT1") (:form . "WT1") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "non-cultured") (:form . "non-cultured") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 90)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 122)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1123.5) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010454@unknown@formal@none@1@S@The allele-specific expression profiles of other imprinted genes, IGF2 and H19, on human chromosome 11 were constant and consistent with those in other tissues.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "allele-specific") (:form . "allele-specific")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "imprinted") (:form . "imprinted") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "igf2") (:form . "IGF2") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h19") (:form . "H19") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "constant") (:form . "constant") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1123.6) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010455@unknown@formal@none@1@S@Our unexpected observations of paternal or biallelic expression of WT1 in fibroblasts and lymphocytes, together with the previous findings of maternal or biallelic expression in placentae and brains, suggest that the allele-specific regulatory system of WT1 is unique and may be controlled by a putative tissue- and individual-specific modifier.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unexpected") (:form . "unexpected") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "paternal") (:form . "paternal") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . 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"NN") (:stem . "tissue-") (:form . "tissue-") (:end . 311)\n  (:start . 304) (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 315) (:start . 312)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "individual-specific")\n  (:form . "individual-specific") (:end . 335) (:start . 316) (:id . 91))\n ((:tag . "NN") (:stem . "modifier") (:form . "modifier") (:end . 344)\n  (:start . 336) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 345) (:start . 344)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x1123.7.1) (:span 272 275))\n  ((:id . :x1123.7.2) (:span 200 207)))\n (:hscopes ((:id . :x1123.7.1) (:span 272 344))\n  ((:id . :x1123.7.2) (:span 200 344)))\n (:identifiers (:sid . :s1123.7) (:did . :|9361029|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010456@unknown@formal@none@1@S@Characterization of CD40 signaling determinants regulating nuclear factor-kappa B activation in B lymphocytes.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 47)\n  (:start . 35) (:id . 46))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 58)\n  (:start . 48) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 79)\n  (:start . 67) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 92)\n  (:start . 82) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 109)\n  (:start . 98) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1124.1) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010457@unknown@formal@none@1@S@CD40 signaling to B cells is important for generating an effective humoral immune response.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "generate") (:form . "generating") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "JJ") (:stem . "humoral") (:form . "humoral") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1124.2) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010458@unknown@formal@none@1@S@CD40 ligation leads to B cell activation events such as proliferation, Ig secretion, isotype switching, and up-regulation of cell surface molecules, as well as the generation of memory B cells.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 121) (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 174)\n  (:start . 164) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 192)\n  (:start . 187) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1124.3) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010460@unknown@formal@none@1@S@To define the CD40 signaling components upstream of NF-kappa B activation and the functional consequences downstream of NF-kappa B activation, we examined mouse B cell transfectants expressing wild-type or mutant human CD40.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 141)\n  (:start . 131) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "transfectant") (:form . "transfectants")\n  (:end . 181) (:start . 168) (:id . 68))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 192)\n  (:start . 182) (:id . 69))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 202)\n  (:start . 193) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 212)\n  (:start . 206) (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 218)\n  (:start . 213) (:id . 73))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 223) (:start . 219)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1124.5) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010461@unknown@formal@none@1@S@Analysis of CD40 cytoplasmic domain truncation and point mutants defined a 10-amino acid CD40 cytoplasmic signaling determinant required for NF-kappa B activation.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "truncation") (:form . "truncation") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "VBD") (:stem . "define") (:form . "defined") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "10-amino") (:form . "10-amino") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "determinant") (:form . "determinant") (:end . 127)\n  (:start . 116) (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 149)\n  (:start . 141) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 151) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1124.6) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010462@unknown@formal@none@1@S@A threonine residue at position 234, previously shown to be important for CD40 association with TNF receptor-associated factor 2 (TRAF2), TRAF3, and TRAF5, was not required for NF-kappa B activation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "threonine") (:form . "threonine") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "CD") (:stem . "234") (:form . "234") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 119) (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TRAF3") (:form . "TRAF3") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TRAF5") (:form . "TRAF5") (:end . 154)\n  (:start . 149) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 172)\n  (:start . 164) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 176) (:start . 173)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 185)\n  (:start . 177) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 187) (:start . 186)\n  (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 198)\n  (:start . 188) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x1124.7.1) (:span 160 163)))\n (:nscopes ((:id . :x1124.7.1) (:span 0 198)))\n (:identifiers (:sid . :s1124.7) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010463@unknown@formal@none@1@S@This suggests that in B cells, CD40-induced NF-kappa B activation can occur independently of TRAF2 and TRAF5 association.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cd40-induced") (:form . "CD40-induced") (:end . 43)\n  (:start . 31) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "traf2") (:form . "TRAF2") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "traf5") (:form . "TRAF5") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1124.8.1) (:span 5 13)))\n (:hscopes ((:id . :x1124.8.1) (:span 5 120)))\n (:identifiers (:sid . :s1124.8) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010464@unknown@formal@none@1@S@NF-kappa B activation was independent of the transmembrane domain of CD40, suggesting that it is independent of p23, a molecule that associates with CD40 in a region other than the cytoplasmic domain.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 58) (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 108)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p23") (:form . "p23") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 165)\n  (:start . 159) (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 171)\n  (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 192)\n  (:start . 181) (:id . 74))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 199)\n  (:start . 193) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1124.9.1) (:span 75 85)))\n (:hscopes ((:id . :x1124.9.1) (:span 75 199)))\n (:identifiers (:sid . :s1124.9) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010465@unknown@formal@none@1@S@Proteasome-dependent inhibitory kappa B alpha (I kappa B alpha) and I kappa B beta degradation occurred downstream of CD40 ligation and preceded CD40-mediated NF-kappa B nuclear translocation.@(((:tag . "JJ") (:stem . "proteasome-dependent")\n  (:form . "Proteasome-dependent") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 31)\n  (:start . 21) (:id . 43))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 37) (:start . 32)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 45))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 45) (:start . 40)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 94)\n  (:start . 83) (:id . 58))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "precede") (:form . "preceded") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 158) (:start . 145) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 191) (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1124.10) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010466@unknown@formal@none@1@S@CD40- or pervanadate-mediated I kappa B tyrosine phosphorylation was not detected.@(((:tag . "NNP") (:stem . "CD40-") (:form . "CD40-") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pervanadate-mediated")\n  (:form . "pervanadate-mediated") (:end . 29) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 64) (:start . 49) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x1124.11.1) (:span 69 72)))\n (:nscopes ((:id . :x1124.11.1) (:span 0 81)))\n (:identifiers (:sid . :s1124.11) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010467@unknown@formal@none@1@S@NF-kappa B activation correlated with the ability of CD40 to induce Ab secretion and the up-regulation of ICAM-1 and LFA-1.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 102) (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lfa-1") (:form . "LFA-1") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1124.12) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010468@unknown@formal@none@1@S@However, NF-kappa B activation was insufficient for CD40-mediated up-regulation of B7-1, Fas, and CD23.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B7-1") (:form . "B7-1") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1124.13) (:did . :|9366415|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010470@unknown@formal@none@1@S@When immunoglobulin (Ig) expressing B cells are fused with non-B cells, Ig expression is rapidly suppressed at the level of transcription, a phenomenon termed extinction.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 19) (:start . 5) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 85)\n  (:start . 75) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 96)\n  (:start . 89) (:id . 59))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 107)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 158)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "extinction") (:form . "extinction") (:end . 169)\n  (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1125.2) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010471@unknown@formal@none@1@S@Here we demonstrate that fusion of HeLa cells with either diploid or tetraploid B cells (Daudi) results in widespread extinction of several other B cell-encoded genes that are expressed in a B cell-specific manner.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "JJ") (:stem . "diploid") (:form . "diploid") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tetraploid") (:form . "tetraploid") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "widespread") (:form . "widespread") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "extinction") (:form . "extinction") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 139)\n  (:start . 132) (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "cell-encoded") (:form . "cell-encoded") (:end . 160)\n  (:start . 148) (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 185)\n  (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 192) (:start . 191)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 206) (:start . 193) (:id . 76))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 213)\n  (:start . 207) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1125.3) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010472@unknown@formal@none@1@S@In contrast, expression of B cell-expressed genes that are not dependent on cell-specific controls is unaffected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cell-expressed") (:form . "cell-expressed")\n  (:end . 43) (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1125.4.1) (:span 59 62)))\n (:nscopes ((:id . :x1125.4.1) (:span 59 98)))\n (:identifiers (:sid . :s1125.4) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010473@unknown@formal@none@1@S@We show that the molecular mechanism(s) underlying Ig gene extinction can be explained, at least in part, by a lack of transcription factors that are essential for Ig gene transcription.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "Ig") (:form . "Ig") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "extinction") (:form . "extinction") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 132) (:start . 119) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 140)\n  (:start . 133) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 159)\n  (:start . 150) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 166) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 185) (:start . 172) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1125.5.1) (:span 111 115)))\n (:nscopes ((:id . :x1125.5.1) (:span 111 185)))\n (:identifiers (:sid . :s1125.5) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010474@unknown@formal@none@1@S@These transcription factors are either not produced due to block of transcription of their respective genes (Oct-2, OBF-1, PU.1), or are rendered inactive posttranslationally (NF-kappa B, E47).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 90)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Oct-2") (:form . "Oct-2") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "OBF-1") (:form . "OBF-1") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PU.1") (:form . "PU.1") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "render") (:form . "rendered") (:end . 145)\n  (:start . 137) (:id . 68))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 154)\n  (:start . 146) (:id . 69))\n ((:tag . "RB") (:stem . "posttranslationally")\n  (:form . "posttranslationally") (:end . 174) (:start . 155) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 184)\n  (:start . 176) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "E47") (:form . "E47") (:end . 191) (:start . 188)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1125.6.2) (:span 32 38 130 132)))\n (:ncues ((:id . :x1125.6.1) (:span 39 42)))\n (:hscopes ((:id . :x1125.6.2) (:span 32 192)))\n (:nscopes ((:id . :x1125.6.1) (:span 39 128)))\n (:identifiers (:sid . :s1125.6) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010475@unknown@formal@none@1@S@By isolating Daudi x HeLa heterokaryons a few hours after fusion, we have studied the initial fate of two B cell-specific transcription factors involved in Ig gene transcription, Oct-2 and NF-kappa B.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "isolate") (:form . "isolating") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "SYM") (:stem . "x") (:form . "x") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "heterokaryon") (:form . "heterokaryons")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "fate") (:form . "fate") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 121) (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 177) (:start . 164) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Oct-2") (:form . "Oct-2") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1125.7) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010476@unknown@formal@none@1@S@This report provides the first demonstration that upon fusion with HeLa cells, the nuclear contents of B cell-expressed transcription factors are depleted within a few hours with kinetics that are as fast or faster than that of Ig gene extinction.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "demonstration") (:form . "demonstration")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "content") (:form . "contents") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cell-expressed") (:form . "cell-expressed")\n  (:end . 119) (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "deplete") (:form . "depleted") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 173)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 187)\n  (:start . 179) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 199) (:start . 197)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "fast") (:form . "fast") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "JJR") (:stem . "fast") (:form . "faster") (:end . 214)\n  (:start . 208) (:id . 76))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 219) (:start . 215)\n  (:id . 77))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 224) (:start . 220)\n  (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 79))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 230) (:start . 228)\n  (:id . 80))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 235) (:start . 231)\n  (:id . 81))\n ((:tag . "NN") (:stem . "extinction") (:form . "extinction") (:end . 246)\n  (:start . 236) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1125.8) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010477@unknown@formal@none@1@S@Thus, the extinguishing mechanism is effective very early after fusion.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "extinguishing") (:form . "extinguishing")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1125.9) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010478@unknown@formal@none@1@S@We suggest that extinction of Ig genes is part of a global mechanism that suppresses the differentiation program foreign to the HeLa phenotype.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "extinction") (:form . "extinction") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ig") (:form . "Ig") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "global") (:form . "global") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 104) (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "JJ") (:stem . "foreign") (:form . "foreign") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1125.10.1) (:span 3 10)))\n (:hscopes ((:id . :x1125.10.1) (:span 3 142)))\n (:identifiers (:sid . :s1125.10) (:did . :|9372447|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010480@unknown@formal@none@1@S@The functions of basic helix-loop-helix (bHLH) transcription factors in activating differentiation-linked gene expression and in inducing G1 cell cycle arrest are negatively regulated by members of the Id family of HLH proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "helix-loop-helix") (:form . "helix-loop-helix")\n  (:end . 39) (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "differentiation-linked")\n  (:form . "differentiation-linked") (:end . 105) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 137)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 140) (:start . 138)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 183)\n  (:start . 174) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 194)\n  (:start . 187) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . "NN") (:stem . "id") (:form . "Id") (:end . 204) (:start . 202)\n  (:id . 71))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 211)\n  (:start . 205) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "hlh") (:form . "HLH") (:end . 218) (:start . 215)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 227)\n  (:start . 219) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1126.2) (:did . :|9372912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010481@unknown@formal@none@1@S@These bHLH antagonists are induced during a mitogenic signalling response, and they function by sequestering their bHLH targets in inactive heterodimers that are unable to bind to specific gene regulatory (E box) sequences.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "sequester") (:form . "sequestering") (:end . 108)\n  (:start . 96) (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 152)\n  (:start . 140) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 168)\n  (:start . 162) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 67))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 176) (:start . 172)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 204)\n  (:start . 194) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 73))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 207) (:start . 206)\n  (:id . 74))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 211) (:start . 208)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 222)\n  (:start . 213) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x1126.3.1) (:span 162 168)))\n (:nscopes ((:id . :x1126.3.1) (:span 158 222)))\n (:identifiers (:sid . :s1126.3) (:did . :|9372912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010482@unknown@formal@none@1@S@Recently, cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2 has been shown to occur during late G1-to-S phase transition of the cell cycle, and this neutralizes the function of Id2 in abrogating E-box-dependent bHLH homo- or heterodimer complex formation in vitro (E.Hara, M.Hall, and G.Peters, EMBO J.16:332-342, 1997).@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "e-cdk2-") (:form . "E-Cdk2-") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cyclin") (:form . "cyclin") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . 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5010483@unknown@formal@none@1@S@We now show that an analogous cell-cycle-regulated phosphorylation of Id3 alters the specificity of Id3 for abrogating both E-box-dependent bHLH homo- or heterodimer complex formation in vitro and E-box-dependent reporter gene function in vivo.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "JJ") (:stem . "cell-cycle-regulated")\n  (:form . "cell-cycle-regulated") (:end . 50) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 66) (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Id3") (:form . "Id3") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "id3") (:form . "Id3") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "abrogate") (:form . "abrogating") (:end . 118)\n  (:start . 108) (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "e-box-dependent") (:form . "E-box-dependent")\n  (:end . 139) (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "homo-") (:form . "homo-") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 165)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 173)\n  (:start . 166) (:id . 65))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 183)\n  (:start . 174) (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 192)\n  (:start . 187) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "e-box-dependent") (:form . "E-box-dependent")\n  (:end . 212) (:start . 197) (:id . 70))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 221)\n  (:start . 213) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 226) (:start . 222)\n  (:id . 72))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 235)\n  (:start . 227) (:id . 73))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 238) (:start . 236)\n  (:id . 74))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 243) (:start . 239)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1126.5) (:did . :|9372912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010484@unknown@formal@none@1@S@Furthermore, compared with wild-type Id3, an Id3 Asp5 mutant (mimicking phosphorylation) is unable to promote cell cycle S phase entry in transfected fibroblasts, whereas an Id3 Ala5 mutant (ablating phosphorylation) displays an activity significantly greater than that of wild-type Id3 protein.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "id3") (:form . "Id3") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . 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5010485@unknown@formal@none@1@S@Cdk2-dependent phosphorylation therefore provides a switch during late G1-to-S phase that both nullifies an early G1 cell cycle regulatory function of Id3 and modulates its target bHLH specificity.@(((:tag . "JJ") (:stem . "cdk2-dependent") (:form . "Cdk2-dependent")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 30) (:start . 15) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 40)\n  (:start . 31) (:id . 44))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 49)\n  (:start . 41) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 46))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 58)\n  (:start . 52) (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 65)\n  (:start . 59) (:id . 48))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "g1-to-s") (:form . "G1-to-S") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 84) (:start . 79)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 94) (:start . 90)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "nullify") (:form . "nullifies") (:end . 104)\n  (:start . 95) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Id3") (:form . "Id3") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 168)\n  (:start . 159) (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "JJ") (:stem . "bhlh") (:form . "bHLH") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 196)\n  (:start . 185) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1126.7) (:did . :|9372912|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010486@unknown@formal@none@1@S@These data also demonstrate that the ability of Id3 to promote cell cycle S phase entry is not simply a function of its ability to modulate bHLH heterodimer-dependent gene expression and establish a biologically important mechanism through which Cdk2 and Id-bHLH functions are integrated in the coordination of cell proliferation and differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ability") (:form . 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5010487@unknown@formal@none@1@S@Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nfat4") (:form . "NFAT4") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "oppose") (:form . "opposed") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1127.1) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010488@unknown@formal@none@1@S@The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 69) (:start . 56) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1127.2) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010490@unknown@formal@none@1@S@This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "calcium-dependent") (:form . "calcium-dependent")\n  (:end . 39) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "dephosphorylation") (:form . "dephosphorylation")\n  (:end . 57) (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 65) (:start . 61)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 72)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 91)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 103)\n  (:start . 92) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1127.4) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010491@unknown@formal@none@1@S@The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 24) (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "phosphorylate") (:form . "phosphorylates")\n  (:end . 52) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "nfat4") (:form . "NFAT4") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1127.5) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010492@unknown@formal@none@1@S@Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4.@(((:tag . "JJ") (:stem . "mutational") (:form . "Mutational") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 45) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 92)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nfat4") (:form . "NFAT4") (:end . 101) (:start . 96)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1127.6) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010493@unknown@formal@none@1@S@In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "calcineurin-stimulated")\n  (:form . "calcineurin-stimulated") (:end . 53) (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "exclusion") (:form . "exclusion") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NN") (:stem . "nfat4") (:form . "NFAT4") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1127.7) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010494@unknown@formal@none@1@S@These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nfat4") (:form . "NFAT4") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "oppose") (:form . "opposed") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 124)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1127.8) (:did . :|9374467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010495@unknown@formal@none@1@S@Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.@(((:tag . "NNP") (:stem . "Hypoxia") (:form . "Hypoxia") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 48)\n  (:start . 42) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "acidosis") (:form . "acidosis") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "proteasome") (:form . "proteasomes") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1128.1) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010496@unknown@formal@none@1@S@Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.@(((:tag . "JJ") (:stem . "intercellular") (:form . "Intercellular")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promotion") (:form . "promotion") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 101) (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 129) (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 139)\n  (:start . 130) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 146)\n  (:start . 140) (:id . 60))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 159)\n  (:start . 147) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1128.2) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010497@unknown@formal@none@1@S@Coincident with many inflammatory diseases is tissue hypoxia.@(((:tag . "JJ") (:stem . "coincident") (:form . "Coincident") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1128.3) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010498@unknown@formal@none@1@S@Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 93) (:start . 79) (:id . 53))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 128)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 135)\n  (:start . 129) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1128.4.1) (:span 75 78)) ((:id . :x1128.4.2) (:span 8 20)))\n (:hscopes ((:id . :x1128.4.1) (:span 75 135))\n  ((:id . :x1128.4.2) (:span 8 135)))\n (:identifiers (:sid . :s1128.4) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010500@unknown@formal@none@1@S@Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 ± 0.4-fold over normoxia) ICAM-1 expression.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "0.4-fold") (:form . "0.4-fold") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "normoxia") (:form . "normoxia") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1128.6.1) (:span 27 30)))\n (:nscopes ((:id . :x1128.6.1) (:span 27 44)))\n (:identifiers (:sid . :s1128.6) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010501@unknown@formal@none@1@S@Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.@(((:tag . "NNS") (:stem . "combination") (:form . "Combinations") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anti-icam-1") (:form . "anti-ICAM-1") (:end . 136)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 147)\n  (:start . 137) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 160)\n  (:start . 151) (:id . 63))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 177) (:start . 161) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1128.7) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010502@unknown@formal@none@1@S@Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.@(((:tag . "JJ") (:stem . "hypoxic") (:form . "Hypoxic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "endothelia") (:form . "endothelia") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 25) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJR") (:stem . ">") (:form . ">") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "10-fold") (:form . "10-fold") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 118)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 146)\n  (:start . 138) (:id . 63))\n ((:tag . "JJ") (:stem . "proteasome-dependent")\n  (:form . "proteasome-dependent") (:end . 167) (:start . 147) (:id . 64))\n ((:tag . "JJ") (:stem . "cytoplasmic-to-nuclear")\n  (:form . "cytoplasmic-to-nuclear") (:end . 190) (:start . 168) (:id . 65))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 203)\n  (:start . 191) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 218)\n  (:start . 211) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 232) (:start . 219) (:id . 70))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 245)\n  (:start . 233) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 247) (:start . 246)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 251) (:start . 248)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 253) (:start . 252)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 256) (:start . 253)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 258) (:start . 257)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 259) (:start . 258)\n  (:id . 77))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 267)\n  (:start . 260) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1128.8) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010503@unknown@formal@none@1@S@Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "hypoxia-evoked") (:form . "hypoxia-evoked")\n  (:end . 57) (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 67)\n  (:start . 58) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 107) (:start . 94) (:id . 53))\n ((:tag . "NN") (:stem . "ph") (:form . "pH") (:end . 110) (:start . 108)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1128.9) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010504@unknown@formal@none@1@S@We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "hypoxia") (:form . "hypoxia") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "proteasome-dependent")\n  (:form . "proteasome-dependent") (:end . 94) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 114)\n  (:start . 108) (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1128.10) (:did . :|9374642|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010505@unknown@formal@none@1@S@Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).@(((:tag . "NN") (:stem . "modulation") (:form . "Modulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "myeloid-selective") (:form . "myeloid-selective")\n  (:end . 64) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "ccaat/enhancer") (:form . "CCAAT/enhancer")\n  (:end . 79) (:start . 65) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 87)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1129.1) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010506@unknown@formal@none@1@S@Human C/EBP epsilon is a newly cloned gene coding for a CCAAT/enhancer binding protein that may be involved in the regulation of myeloid differentiation.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 49) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ccaat/enhancer") (:form . "CCAAT/enhancer")\n  (:end . 70) (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 152) (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1129.2.1) (:span 92 95)))\n (:hscopes ((:id . :x1129.2.1) (:span 92 152)))\n (:identifiers (:sid . :s1129.2) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010507@unknown@formal@none@1@S@Our studies showed that levels of C/EBP epsilon mRNA were markedly increased in NB4 cells (promyelocytic leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards granulocytes.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 18) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "promyelocytic") (:form . "promyelocytic")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 133) (:start . 129)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 164)\n  (:start . 156) (:id . 69))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "9-cis") (:form . "9-cis") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 183) (:start . 181)\n  (:id . 75))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 197) (:start . 184) (:id . 76))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 205)\n  (:start . 198) (:id . 77))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 218)\n  (:start . 206) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1129.3) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5010510@unknown@formal@none@1@S@NB4 cells pulse-exposed (30 minutes) to all-trans retinoic acid (ATRA), washed, and cultured (3 days) with either dimethylsulfoxide (DMSO) or hexamethylene bisacetamide (HMBA) had a prominent increase in levels of C/EBP epsilon mRNA and an increase in granulocytic differentiation, but exposure to either DMSO or HMBA alone had no effect on base levels of C/EBP epsilon and did not induce differentiation.@(((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "pulse-exposed") (:form . "pulse-exposed")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "minute") (:form . 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5010511@unknown@formal@none@1@S@Macrophage-differentiation of NB4 reduced levels of C/EBP epsilon mRNA.@(((:tag . "NNP") (:stem . "Macrophage-differentiation")\n  (:form . "Macrophage-differentiation") (:end . 26) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NB4") (:form . "NB4") (:end . 33) (:start . 30)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 41)\n  (:start . 34) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 48)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1129.7) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010512@unknown@formal@none@1@S@Nuclear run-off assays and half-life studies showed that accumulation of C/EBP epsilon mRNA by 9-cis RA was due to enhanced transcription.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "run-off") (:form . "run-off") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 51) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 137) (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1129.8) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010513@unknown@formal@none@1@S@Furthermore, this C/EBP epsilon mRNA accumulation did not require synthesis of new protein factors because 9-cis RA induced C/EBP epsilon mRNA accumulation in the absence of new protein synthesis.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 155)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 170)\n  (:start . 163) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 195)\n  (:start . 186) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1129.9.1) (:span 163 170))\n  ((:id . :x1129.9.2) (:span 54 57)))\n (:nscopes ((:id . :x1129.9.1) (:span 163 195))\n  ((:id . :x1129.9.2) (:span 54 98)))\n (:identifiers (:sid . :s1129.9) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010514@unknown@formal@none@1@S@ATRA also induced expression of C/EBP epsilon protein in NB4 cells, as shown by Western blotting.@(((:tag . "NNP") (:stem . "ATRA") (:form . "ATRA") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1129.10) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010515@unknown@formal@none@1@S@In contrast to the increase of C/EBP epsilon in 9-cis RA-mediated granulocytic differentiation, the DMSO-induced differentiation of HL-60 cells down the granulocytic pathway was associated with an initial reduction of C/EBP epsilon mRNA levels.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "9-cis") (:form . "9-cis") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ra-mediated") (:form . "RA-mediated") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 78)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 94) (:start . 79) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dmso-induced") (:form . "DMSO-induced") (:end . 112)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 128) (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hl-60") (:form . "HL-60") (:end . 137)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 143)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "down") (:form . "down") (:end . 148) (:start . 144)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 165)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 173)\n  (:start . 166) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 177) (:start . 174)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 188)\n  (:start . 178) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 196) (:start . 194)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 204)\n  (:start . 197) (:id . 70))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 214)\n  (:start . 205) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 223)\n  (:start . 218) (:id . 73))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 231)\n  (:start . 224) (:id . 74))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 236) (:start . 232)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 243)\n  (:start . 237) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1129.11) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010516@unknown@formal@none@1@S@In summary, we have discovered that expression of C/EBP epsilon mRNA is markedly enhanced as the NB4 promyelocytes are induced by retinoids to differentiate towards granulocytes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nb4") (:form . "NB4") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "promyelocyte") (:form . "promyelocytes")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 156) (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 177)\n  (:start . 165) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1129.12) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010517@unknown@formal@none@1@S@This induction of C/EBP epsilon mRNA expression is transcriptionally mediated and occurs in the absence of synthesis of additional protein factors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 68) (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 146)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1129.13.1) (:span 96 103)))\n (:nscopes ((:id . :x1129.13.1) (:span 96 146)))\n (:identifiers (:sid . :s1129.13) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010518@unknown@formal@none@1@S@We suspect that the C/EBP epsilon promoter/enhancer contains a retinoic acid-response element that is directly stimulated by retinoids.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suspect") (:form . "suspect") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "promoter/enhancer") (:form . "promoter/enhancer")\n  (:end . 51) (:start . 34) (:id . 48))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "JJ") (:stem . "acid-response") (:form . "acid-response")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 121)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1129.14.1) (:span 3 10)))\n (:hscopes ((:id . :x1129.14.1) (:span 3 134)))\n (:identifiers (:sid . :s1129.14) (:did . :|9376579|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010520@unknown@formal@none@1@S@Blood monocytes from patients with active tuberculosis are activated in vivo, as evidenced by an increase in the stimulated release of proinflammatory cytokines, such as TNF-alpha, and the spontaneous expression of IL-2R.@(((:tag . "NNP") (:stem . "Blood") (:form . "Blood") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 150) (:start . 135) (:id . 64))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "spontaneous") (:form . "spontaneous") (:end . 200)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 211)\n  (:start . 201) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 220)\n  (:start . 215) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1130.2) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010521@unknown@formal@none@1@S@Further, monocytes from patients demonstrate an augmented susceptibility to a productive infection with HIV-1 in vitro.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "augmented") (:form . "augmented") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "susceptibility") (:form . "susceptibility")\n  (:end . 72) (:start . 58) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "productive") (:form . "productive") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1130.3) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010522@unknown@formal@none@1@S@Mycobacterium tuberculosis and its components are strong signals to activate monocytes to production of cytokines.@(((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 26)\n  (:start . 14) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 100)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1130.4) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010523@unknown@formal@none@1@S@In this study we examined the basis of activation of monocytes during active tuberculosis and by M. tuberculosis.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 112)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1130.5) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010524@unknown@formal@none@1@S@We found a constitutive degradation of I kappa B-alpha, the major cytoplasmic inhibitor of nuclear factor kappa B (NF-kappa B), in freshly isolated PBMC and monocytes from patients with tuberculosis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 77)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 138)\n  (:start . 131) (:id . 67))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 147)\n  (:start . 139) (:id . 68))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 166)\n  (:start . 157) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 180)\n  (:start . 172) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 198)\n  (:start . 186) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1130.6) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010525@unknown@formal@none@1@S@In contrast, I kappa B-alpha levels in PBMC and monocytes from healthy subjects or from patients with nontuberculous pulmonary conditions were intact.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nontuberculous") (:form . "nontuberculous")\n  (:end . 116) (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1130.7) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010526@unknown@formal@none@1@S@Further, by electrophoretic mobility shift assay, NF-kappa B was activated in monocytes from tuberculous patients.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 27) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tuberculous") (:form . "tuberculous") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1130.8) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010527@unknown@formal@none@1@S@The expression of I kappa B-alpha gene, which is responsive to activation by NF-kappa B, was up-regulated in PBMC and monocytes from patients, but not in mononuclear cells from healthy subjects or those with nontuberculous lung diseases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B-alpha") (:form . "B-alpha") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 105)\n  (:start . 93) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 127)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 141)\n  (:start . 133) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 165)\n  (:start . 154) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 176) (:start . 172)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 184)\n  (:start . 177) (:id . 74))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 193)\n  (:start . 185) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 196) (:start . 194)\n  (:id . 76))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 202)\n  (:start . 197) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 207) (:start . 203)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nontuberculous") (:form . "nontuberculous")\n  (:end . 222) (:start . 208) (:id . 79))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 227) (:start . 223)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 236)\n  (:start . 228) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x1130.9.1) (:span 147 150)))\n (:nscopes ((:id . :x1130.9.1) (:span 147 236)))\n (:identifiers (:sid . :s1130.9) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010528@unknown@formal@none@1@S@By contrast, the expression of other adherence-associated early genes, such as IL-8 and IL-1 beta, was not up-regulated in PBMC of tuberculous patients.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adherence-associated")\n  (:form . "adherence-associated") (:end . 57) (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 119)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "tuberculous") (:form . "tuberculous") (:end . 142)\n  (:start . 131) (:id . 66))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1130.10.1) (:span 103 106)))\n (:nscopes ((:id . :x1130.10.1) (:span 13 151)))\n (:identifiers (:sid . :s1130.10) (:did . :|9379002|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010530@unknown@formal@none@1@S@Expression of c-fos correlates with IFN-alpha responsiveness in Philadelphia chromosome positive chronic myelogenous leukemia.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IFN-alpha") (:form . "IFN-alpha") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 60) (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Philadelphia") (:form . "Philadelphia") (:end . 76)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 96)\n  (:start . 88) (:id . 52))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 104)\n  (:start . 97) (:id . 53))\n ((:tag . "JJ") (:stem . "myelogenous") (:form . "myelogenous") (:end . 116)\n  (:start . 105) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 125)\n  (:start . 117) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1131.1) (:did . :|9384661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010531@unknown@formal@none@1@S@This study evaluates (i) constitutive levels of oncogene and p53 transcripts in chronic phase CML patients and (ii) their modulations subsequent to in vivo therapy with rIFN-alpha 2c.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "evaluate") (:form . "evaluates") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 37)\n  (:start . 25) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CML") (:form . "CML") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "NNS") (:stem . "modulation") (:form . "modulations") (:end . 133)\n  (:start . 122) (:id . 65))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 163)\n  (:start . 156) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "rifn-alpha") (:form . "rIFN-alpha") (:end . 179)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "2c") (:form . "2c") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1131.2) (:did . :|9384661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010532@unknown@formal@none@1@S@Peripheral blood mononuclear cells (pbmc) and bone marrow cells of 26 patients were examined for c-fos, c-myc, p53 and the hybrid bcr/abl mRNA levels.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pbmc") (:form . "pbmc") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "NN") (:stem . "hybrid") (:form . "hybrid") (:end . 129)\n  (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "bcr/abl") (:form . "bcr/abl") (:end . 137)\n  (:start . 130) (:id . 67))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 149)\n  (:start . 143) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1131.3) (:did . :|9384661|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010533@unknown@formal@none@1@S@Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl, c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . 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5010534@unknown@formal@none@1@S@Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 49) (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 52))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 100)\n  (:start . 95) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1132.1) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010535@unknown@formal@none@1@S@Transcription factors of the NFAT (nuclear factor of activated T cells) family play important roles in immune and inflammatory responses by regulating the expression of genes encoding cytokines and immunoregulatory proteins.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 126)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 136)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 69))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 183)\n  (:start . 175) (:id . 70))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 193)\n  (:start . 184) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "immunoregulatory") (:form . "immunoregulatory")\n  (:end . 214) (:start . 198) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 223)\n  (:start . 215) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1132.2) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010536@unknown@formal@none@1@S@Here we describe cloning and characterization of full-length cDNA encoding murine (m) NFATc which predicts that the protein has all the conserved structural motifs of NFAT family members, including the rel homology domain, the NFAT homology domain and the nuclear translocation signals.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 45) (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFATc") (:form . "NFATc") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 163)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 186)\n  (:start . 179) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "rel") (:form . "rel") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 221)\n  (:start . 215) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 231) (:start . 227)\n  (:id . 80))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 240)\n  (:start . 232) (:id . 81))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 247)\n  (:start . 241) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 251) (:start . 248)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 255) (:start . 252)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 263)\n  (:start . 256) (:id . 85))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 277) (:start . 264) (:id . 86))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 285)\n  (:start . 278) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s1132.3) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010537@unknown@formal@none@1@S@mNFATc complexed with AP-1 bound specifically to the murine IL-2 NFAT recognition sequence and activated transcription from the co-transfected IL-2 promoter in COS-7 cells.@(((:tag . "NN") (:stem . "mnfatc") (:form . "mNFATc") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "complexe") (:form . "complexed") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "co-transfected") (:form . "co-transfected")\n  (:end . 142) (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 156)\n  (:start . 148) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cos-7") (:form . "COS-7") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1132.4) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010538@unknown@formal@none@1@S@Northern blot analysis showed that the cDNA probe hybridized with a 4.5 kb transcript which is highly inducible in murine T cells.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "hybridize") (:form . "hybridized") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "4.5") (:form . "4.5") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1132.5) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010540@unknown@formal@none@1@S@In the mouse embryo, mNFATc transcript was strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart suggesting that mNFATc may have a role both in embryogenesis and in mature T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "embryo") (:form . "embryo") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mnfatc") (:form . "mNFATc") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "submandibular") (:form . "submandibular")\n  (:end . 95) (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "skeletal") (:form . "skeletal") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "heart") (:form . "heart") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mnfatc") (:form . "mNFATc") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 180) (:start . 176)\n  (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 185) (:start . 181)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 188) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "embryogenesis") (:form . "embryogenesis")\n  (:end . 202) (:start . 189) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 209) (:start . 207)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 216)\n  (:start . 210) (:id . 78))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 218) (:start . 217)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 224)\n  (:start . 219) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1132.7.1) (:span 165 168))\n  ((:id . :x1132.7.2) (:span 142 152)))\n (:hscopes ((:id . :x1132.7.1) (:span 165 224))\n  ((:id . :x1132.7.2) (:span 142 224)))\n (:identifiers (:sid . :s1132.7) (:did . :|9388475|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010541@unknown@formal@none@1@S@Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.@(((:tag . "NNP") (:stem . "Phosphatidylinositol")\n  (:form . "Phosphatidylinositol") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 29)\n  (:start . 21) (:id . 43))\n ((:tag . "VBZ") (:stem . "couple") (:form . "couples") (:end . 37)\n  (:start . 30) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 55) (:start . 42) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 64)\n  (:start . 56) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 82) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 92)\n  (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1133.1) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010542@unknown@formal@none@1@S@Cell cycle progression initiated by interleukin-2 (IL-2) in T cells is critical for lymphoproliferation and an immune response.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymphoproliferation")\n  (:form . "lymphoproliferation") (:end . 103) (:start . 84) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1133.2) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010543@unknown@formal@none@1@S@Phosphatidyl inositol 3-kinase (PI3K) is activated by IL-2.@(((:tag . "NNP") (:stem . "Phosphatidyl") (:form . "Phosphatidyl") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PI3K") (:form . "PI3K") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1133.3) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010544@unknown@formal@none@1@S@However, nuclear targets for PI3K are not known.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PI3K") (:form . "PI3K") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x1133.4.1) (:span 38 47)))\n (:hscopes ((:id . :x1133.4.1) (:span 9 47)))\n (:identifiers (:sid . :s1133.4) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010545@unknown@formal@none@1@S@Here we identify the cell cycle regulator E2F as an IL-2 target in T lymphocytes and PI3K as the critical signaling pathway.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pi3k") (:form . "PI3K") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 105)\n  (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 115)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1133.5) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010546@unknown@formal@none@1@S@We eliminate both Stat5 and Raf/MEK pathways from E2F regulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "eliminate") (:form . "eliminate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stat5") (:form . "Stat5") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Raf/MEK") (:form . "Raf/MEK") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1133.6) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010547@unknown@formal@none@1@S@Protein kinase B (PKB) is activated by IL-2 via PI3K.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PKB") (:form . "PKB") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 35)\n  (:start . 26) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 47) (:start . 44)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PI3K") (:form . "PI3K") (:end . 52) (:start . 48)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1133.7) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010548@unknown@formal@none@1@S@The expression of an active PKB is sufficient to induce E2F activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "pkb") (:form . "PKB") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1133.8) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010550@unknown@formal@none@1@S@These results establish a crucial PI3K/PKB-mediated link between the IL-2 teceptor and the cell cycle machinery.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "pi3k/pkb-mediated") (:form . "PI3K/PKB-mediated")\n  (:end . 51) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "teceptor") (:form . "teceptor") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1133.10) (:did . :|9390691|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010551@unknown@formal@none@1@S@Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B.@(((:tag . "NNP") (:stem . "Thiol") (:form . "Thiol") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "IL)-1-mediated") (:form . "IL)-1-mediated")\n  (:end . 57) (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 99) (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 107)\n  (:start . 100) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 114)\n  (:start . 108) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 127)\n  (:start . 119) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1134.1) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010552@unknown@formal@none@1@S@The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-1RI") (:form . "IL-1RI") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "form") (:form . "forming") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "exert") (:form . "exerts") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 139)\n  (:start . 132) (:id . 65))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1134.2) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5010554@unknown@formal@none@1@S@IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation.@(((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "subject") (:form . "subject") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1134.4.1) (:span 69 76)))\n (:hscopes ((:id . :x1134.4.1) (:span 66 110)))\n (:identifiers (:sid . :s1134.4) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010555@unknown@formal@none@1@S@We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "il-1ri-associated") (:form . "IL-1RI-associated")\n  (:end . 73) (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 116)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 189)\n  (:start . 180) (:id . 69))\n ((:tag . "JJ") (:stem . "il-1-mediated") (:form . "IL-1-mediated")\n  (:end . 203) (:start . 190) (:id . 70))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 212)\n  (:start . 204) (:id . 71))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 214) (:start . 213)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 225)\n  (:start . 215) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1134.5.1) (:span 174 179))\n  ((:id . :x1134.5.2) (:span 132 139)) ((:id . :x1134.5.3) (:span 89 94))\n  ((:id . :x1134.5.4) (:span 26 33)))\n (:hscopes ((:id . :x1134.5.1) (:span 174 225))\n  ((:id . :x1134.5.2) (:span 132 225)) ((:id . :x1134.5.3) (:span 89 127))\n  ((:id . :x1134.5.4) (:span 26 127)))\n (:identifiers (:sid . :s1134.5) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010556@unknown@formal@none@1@S@A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EL4") (:form . "EL4") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 41)\n  (:start . 31) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 51) (:start . 47)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 68)\n  (:start . 61) (:id . 56))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 81)\n  (:start . 69) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 96)\n  (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 151)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1134.6.1) (:span 61 68)))\n (:nscopes ((:id . :x1134.6.1) (:span 61 151)))\n (:identifiers (:sid . :s1134.6) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010557@unknown@formal@none@1@S@Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase.@(((:tag . "NNP") (:stem . "Thiol") (:form . "Thiol") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "modify") (:form . "modifying") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "diamide") (:form . "diamide") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "menadione") (:form . "menadione") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "diethyl") (:form . "diethyl") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 107) (:start . 92) (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phenylarsine") (:form . "phenylarsine") (:end . 123)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 139)\n  (:start . 130) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 156)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 167)\n  (:start . 157) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "il-1ri-associated") (:form . "IL-1RI-associated")\n  (:end . 192) (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 200)\n  (:start . 193) (:id . 68))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 207)\n  (:start . 201) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1134.7) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010558@unknown@formal@none@1@S@N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect.@(((:tag . "NNP") (:stem . "N-Acetylcysteine") (:form . "N-Acetylcysteine")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "alpha,alpha'-dipyridyl")\n  (:form . "alpha,alpha'-dipyridyl") (:end . 40) (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 45))\n ((:tag . "NN") (:stem . "aminotriazole") (:form . "aminotriazole")\n  (:end . 55) (:start . 42) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 58) (:start . 56)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nitrofurantoin") (:form . "nitrofurantoin")\n  (:end . 73) (:start . 59) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 77) (:start . 74)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 50))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 86) (:start . 82)\n  (:id . 51))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 90) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 97)\n  (:start . 91) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x1134.8.1) (:span 78 81)))\n (:nscopes ((:id . :x1134.8.1) (:span 78 97)))\n (:identifiers (:sid . :s1134.8) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010560@unknown@formal@none@1@S@The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "il-1ri-associated") (:form . "IL-1RI-associated")\n  (:end . 93) (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 100)\n  (:start . 94) (:id . 54))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 110)\n  (:start . 101) (:id . 55))\n ((:tag . "VBD") (:stem . "impair") (:form . "impaired") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 146)\n  (:start . 138) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 62))\n ((:tag . "NN") (:stem . "el4") (:form . "EL4") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1134.10) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010561@unknown@formal@none@1@S@From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "thiol") (:form . "thiols") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL-1RI") (:form . "IL-1RI") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "il-1ri-associated") (:form . "IL-1RI-associated")\n  (:end . 132) (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mandatory") (:form . "mandatory") (:end . 182)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 186) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 191) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 201)\n  (:start . 192) (:id . 72))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 209)\n  (:start . 202) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 221)\n  (:start . 213) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 223) (:start . 222)\n  (:id . 76))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 234)\n  (:start . 224) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1134.11) (:did . :|9394832|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010562@unknown@formal@none@1@S@ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element.@(((:tag . "NNP") (:stem . "ATF1") (:form . "ATF1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "trans-activate") (:form . "trans-activate")\n  (:end . 28) (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "associated") (:form . "associated") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1135.1) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010563@unknown@formal@none@1@S@Proteins of the ATF/CREB class of transcription factors stimulate gene expression of several cell growth-related genes through protein kinase A-related cAMP response elements.@(((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ATF/CREB") (:form . "ATF/CREB") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "VBP") (:stem . "stimulate") (:form . "stimulate") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "growth-related") (:form . "growth-related")\n  (:end . 112) (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . "JJ") (:stem . "a-related") (:form . "A-related") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 156) (:start . 152)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 165)\n  (:start . 157) (:id . 63))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 174)\n  (:start . 166) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1135.2) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010564@unknown@formal@none@1@S@The promoter activity of cell cycle regulated histone H4 genes is regulated by at least four principal cis-acting elements which mediate G1/S phase control and/or enhancement of transcription during the cell cycle.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "principal") (:form . "principal") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "g1/s") (:form . "G1/S") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 174)\n  (:start . 163) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 191) (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 198)\n  (:start . 192) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 207) (:start . 203)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 213)\n  (:start . 208) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1135.3) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010565@unknown@formal@none@1@S@Using protein-DNA interaction assays we show that the H4 promoter contains two ATF/CREB recognition motifs which interact with CREB, ATF1, and ATF2 but not with ATF4/CREB2.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ATF/CREB") (:form . "ATF/CREB") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "ATF1") (:form . "ATF1") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "atf2") (:form . "ATF2") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "atf4/creb2") (:form . "ATF4/CREB2") (:end . 171)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1135.4.1) (:span 152 155)))\n (:nscopes ((:id . :x1135.4.1) (:span 152 171)))\n (:identifiers (:sid . :s1135.4) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010566@unknown@formal@none@1@S@One ATF/CRE motif is located in the distal promoter at the nuclear matrix-associated Site IV, and the second motif is present in the proximal promoter at Site I.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ATF/CRE") (:form . "ATF/CRE") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "matrix-associated") (:form . "matrix-associated")\n  (:end . 84) (:start . 67) (:id . 54))\n ((:tag . "NNP") (:stem . "Site") (:form . "Site") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 141)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Site") (:form . "Site") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1135.5) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010567@unknown@formal@none@1@S@Both ATF/CRE motifs overlap binding sequences for the multifunctional YY1 transcription factor, which has previously been shown to be nuclear matrix associated.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ATF/CRE") (:form . "ATF/CRE") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multifunctional") (:form . "multifunctional")\n  (:end . 69) (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "yy1") (:form . "YY1") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 101)\n  (:start . 96) (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1135.6) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010568@unknown@formal@none@1@S@Subnuclear fractionation reveals that there are two ATF1 isoforms which appear to differ with respect to DNA binding activity and partition selectively between nuclear matrix and nonmatrix compartments, consistent with the role of the nuclear matrix in regulating gene expression.@(((:tag . "JJ") (:stem . "subnuclear") (:form . "Subnuclear") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "fractionation") (:form . "fractionation")\n  (:end . 24) (:start . 11) (:id . 43))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "atf1") (:form . "ATF1") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "partition") (:form . "partition") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 151)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 159)\n  (:start . 152) (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 167)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 174)\n  (:start . 168) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nonmatrix") (:form . "nonmatrix") (:end . 188)\n  (:start . 179) (:id . 68))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 201)\n  (:start . 189) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 213)\n  (:start . 203) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 218) (:start . 214)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 227) (:start . 223)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 242)\n  (:start . 235) (:id . 77))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 249)\n  (:start . 243) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 263)\n  (:start . 253) (:id . 80))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 268) (:start . 264)\n  (:id . 81))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 279)\n  (:start . 269) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1135.7.1) (:span 72 78)))\n (:hscopes ((:id . :x1135.7.1) (:span 66 279)))\n (:identifiers (:sid . :s1135.7) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010570@unknown@formal@none@1@S@Thus, our data establish that ATF/CREB factors functionally modulate histone H4 gene transcription at distal and proximal promoter elements.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ATF/CREB") (:form . "ATF/CREB") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 139)\n  (:start . 131) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1135.9) (:did . :|9398163|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010571@unknown@formal@none@1@S@IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts.@(((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "heterodimerization") (:form . "heterodimerization")\n  (:end . 39) (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphoblast") (:form . "lymphoblasts") (:end . 98)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1136.1) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010572@unknown@formal@none@1@S@Despite differences in T cell responses induced by interleukin (IL)-2 and IL-7, both cytokines modulate T cell functions by activation of signal transducers and activators of transcription (STAT) proteins.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "IL)-2") (:form . "IL)-2") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 171)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 188) (:start . 175) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 194) (:start . 190)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 195) (:start . 194)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 204)\n  (:start . 196) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1136.2) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010573@unknown@formal@none@1@S@We examined the contribution of the two isoforms of STAT5, STAT5A and STAT5B, to IL-2- and IL-7-induced activation of human peripheral blood T lymphoblasts.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-2-") (:form . "IL-2-") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "il-7-induced") (:form . "IL-7-induced") (:end . 103)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 134)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "lymphoblast") (:form . "lymphoblasts") (:end . 155)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1136.3) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010574@unknown@formal@none@1@S@Both cytokines induced assembly of STAT5A and STAT5B containing complexes capable of binding to the interferon-gamma activation sequence (GAS), and these complexes rapidly translocated (within 1 min) into the nucleus of IL-2- or IL-7-treated cells.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 81)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 116) (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 136)\n  (:start . 128) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 153)\n  (:start . 148) (:id . 65))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 163)\n  (:start . 154) (:id . 66))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "VBD") (:stem . "translocate") (:form . "translocated") (:end . 184)\n  (:start . 172) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 69))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 192)\n  (:start . 186) (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 198) (:start . 195)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 216)\n  (:start . 209) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "NN") (:stem . "il-2-") (:form . "IL-2-") (:end . 225)\n  (:start . 220) (:id . 78))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 228) (:start . 226)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "il-7-treated") (:form . "IL-7-treated") (:end . 241)\n  (:start . 229) (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 247)\n  (:start . 242) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1136.4) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010575@unknown@formal@none@1@S@The kinetics of this translocation were delayed in IL-7-treated as compared to IL-2-treated cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "il-7-treated") (:form . "IL-7-treated") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "il-2-treated") (:form . "IL-2-treated") (:end . 91)\n  (:start . 79) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1136.5) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010576@unknown@formal@none@1@S@IL-2 and IL-7 were equivalent in their ability to induce tyrosine phosphorylation of STAT5A and STAT5B and to facilitate binding of these STATs to an immobilized GAS element.@(((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 38)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 81) (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "STAT5A") (:form . "STAT5A") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT5B") (:form . "STAT5B") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "immobilize") (:form . "immobilized") (:end . 161)\n  (:start . 150) (:id . 67))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1136.6) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010577@unknown@formal@none@1@S@Both IL-2 and IL-7 induced substantial amounts of STAT5A/STAT5B heterodimerization.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5A/STAT5B") (:form . "STAT5A/STAT5B")\n  (:end . 63) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "heterodimerization") (:form . "heterodimerization")\n  (:end . 82) (:start . 64) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1136.7) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010578@unknown@formal@none@1@S@Moreover, we observed constitutive association of STAT3 with each STAT5 isomer.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "isomer") (:form . "isomer") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1136.8) (:did . :|9398404|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010580@unknown@formal@none@1@S@Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anoxia/reoxygenation-induced")\n  (:form . "anoxia/reoxygenation-induced") (:end . 52) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 63)\n  (:start . 53) (:id . 46))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 73)\n  (:start . 64) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 85)\n  (:start . 77) (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 97)\n  (:start . 86) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1137.1) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010581@unknown@formal@none@1@S@The objectives of this study were to (1) determine the time course of neutrophil adhesion to monolayers of human umbilical vein endothelial cells (HUVECs) that were exposed to 60 minutes of anoxia followed by 30 to 600 minutes of reoxygenation and (2) define the mechanisms responsible for both the early (minutes) and late (hours) hyperadhesivity of postanoxic HUVECs to human neutrophils.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "objective") (:form . "objectives") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . 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5010582@unknown@formal@none@1@S@The results clearly demonstrate that anoxia/reoxygenation (A/R) leads to a biphasic increase in neutrophil adhesion to HUVECs, with peak responses occurring at 30 minutes (phase 1) and 240 minutes (phase 2) after reoxygenation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "anoxia/reoxygenation")\n  (:form . "anoxia/reoxygenation") (:end . 57) (:start . 37) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "biphasic") (:form . "biphasic") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 146)\n  (:start . 137) (:id . 64))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 156)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 170)\n  (:start . 163) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 177)\n  (:start . 172) (:id . 70))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 179) (:start . 178)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "CD") (:stem . "240") (:form . "240") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "minute") (:form . "minutes") (:end . 196)\n  (:start . 189) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 76))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 203)\n  (:start . 198) (:id . 77))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 205) (:start . 204)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 79))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 212)\n  (:start . 207) (:id . 80))\n ((:tag . "NN") (:stem . "reoxygenation") (:form . "reoxygenation")\n  (:end . 226) (:start . 213) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1137.3) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010583@unknown@formal@none@1@S@Oxypurinol and catalase inhibited phase-1 adhesion, suggesting a role for xanthine oxidase and H2O2.@(((:tag . "NNP") (:stem . "Oxypurinol") (:form . "Oxypurinol") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "phase-1") (:form . "phase-1") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "xanthine") (:form . "xanthine") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "oxidase") (:form . "oxidase") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1137.4.1) (:span 52 62)))\n (:hscopes ((:id . :x1137.4.1) (:span 52 99)))\n (:identifiers (:sid . :s1137.4) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010584@unknown@formal@none@1@S@In comparison, platelet activating factor (PAF) contributed to both phases of neutrophil adhesion.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "platelet") (:form . "platelet") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "activating") (:form . "activating") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PAF") (:form . "PAF") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "contribute") (:form . "contributed") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "phase") (:form . "phases") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1137.5) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010585@unknown@formal@none@1@S@Anti-intercellular adhesion molecule-1 (ICAM-1) and anti-P-selectin antibodies (monoclonal antibodies [mAbs]) attenuated phase-1 neutrophil adhesion, consistent with roles for constitutively expressed ICAM-1 and enhanced surface expression of preformed P-selectin.@(((:tag . "JJ") (:stem . "anti-intercellular") (:form . "Anti-intercellular")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 27)\n  (:start . 19) (:id . 43))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 38)\n  (:start . 28) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 45))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 46)\n  (:start . 40) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-p-selectin") (:form . "anti-P-selectin")\n  (:end . 67) (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 103) (:start . 102)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 107) (:start . 103)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 108) (:start . 107)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "JJ") (:stem . "phase-1") (:form . "phase-1") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 148)\n  (:start . 140) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 160)\n  (:start . 150) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 66))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 190) (:start . 176) (:id . 67))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 200)\n  (:start . 191) (:id . 68))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 207)\n  (:start . 201) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 220)\n  (:start . 212) (:id . 71))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 228)\n  (:start . 221) (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 239)\n  (:start . 229) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 242) (:start . 240)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "preformed") (:form . "preformed") (:end . 252)\n  (:start . 243) (:id . 75))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 263)\n  (:start . 253) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1137.6) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010586@unknown@formal@none@1@S@Phase-2 neutrophil adhesion was attenuated by an anti-E-selectin mAb, indicating a dominant role of this adhesion molecule in the late phase response.@(((:tag . "NN") (:stem . "phase-2") (:form . "Phase-2") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "attenuate") (:form . "attenuated") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-e-selectin") (:form . "anti-E-selectin")\n  (:end . 64) (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1137.7.1) (:span 70 80)))\n (:hscopes ((:id . :x1137.7.1) (:span 70 149)))\n (:identifiers (:sid . :s1137.7) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010587@unknown@formal@none@1@S@Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides containing the nuclear factor-kappa B or activator protein-1 cognate DNA sequences significantly attenuated phase-2 response, suggesting a role for de novo macromolecule synthesis.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "actinomycin") (:form . "actinomycin") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "compete") (:form . "competing") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "ds-oligonucleotide")\n  (:form . "ds-oligonucleotides") (:end . 87) (:start . 68) (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 98)\n  (:start . 88) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 54))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 123)\n  (:start . 111) (:id . 55))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 138)\n  (:start . 129) (:id . 58))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 148)\n  (:start . 139) (:id . 59))\n ((:tag . "NN") (:stem . "cognate") (:form . "cognate") (:end . 156)\n  (:start . 149) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 160) (:start . 157)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 170)\n  (:start . 161) (:id . 62))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 184) (:start . 171) (:id . 63))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 195)\n  (:start . 185) (:id . 64))\n ((:tag . "NN") (:stem . "phase-2") (:form . "phase-2") (:end . 203)\n  (:start . 196) (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 212)\n  (:start . 204) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 224)\n  (:start . 214) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 226) (:start . 225)\n  (:id . 69))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 231) (:start . 227)\n  (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 235) (:start . 232)\n  (:id . 71))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 238) (:start . 236)\n  (:id . 72))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 243) (:start . 239)\n  (:id . 73))\n ((:tag . "NN") (:stem . "macromolecule") (:form . "macromolecule")\n  (:end . 257) (:start . 244) (:id . 74))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 267)\n  (:start . 258) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1137.8.1) (:span 214 224)))\n (:hscopes ((:id . :x1137.8.1) (:span 214 267)))\n (:identifiers (:sid . :s1137.8) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010588@unknown@formal@none@1@S@Surface expression of ICAM-1, P-selectin, and E-selectin on HUVECs correlated with the phase-1 and -2 neutrophil adhesion responses.@(((:tag . "NN") (:stem . "surface") (:form . "Surface") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "P-selectin") (:form . "P-selectin") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phase-1") (:form . "phase-1") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-2") (:form . "-2") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1137.9) (:did . :|9400372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010590@unknown@formal@none@1@S@c-Rel and p65 subunits bind to an upstream NF-kappaB site in human granulocyte macrophage-colony stimulating factor promoter involved in phorbol ester response in 5637 cells.@(((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 78)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "macrophage-colony") (:form . "macrophage-colony")\n  (:end . 96) (:start . 79) (:id . 55))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 144)\n  (:start . 137) (:id . 61))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 150)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 64))\n ((:tag . "CD") (:stem . "5637") (:form . "5637") (:end . 167) (:start . 163)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 173)\n  (:start . 168) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1138.1) (:did . :|9414129|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010591@unknown@formal@none@1@S@To further clarify the complex transcriptional regulation of the human GM-CSF gene, which was extensively investigated in activated T cells, we have studied the role of an upstream NF-kappaB like site in the 5637 non-lymphoid cell line, which derives from a bladder carcinoma and constitutively produces GM-CSF.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "clarify") (:form . "clarify") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . 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"and") (:end . 279) (:start . 276)\n  (:id . 88))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 294) (:start . 280) (:id . 89))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 303)\n  (:start . 295) (:id . 90))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 310)\n  (:start . 304) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 311) (:start . 310)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s1138.2) (:did . :|9414129|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010592@unknown@formal@none@1@S@This sequence, named the A element, has an active role on GM-CSF transcription and is responsive to the tumor promoter PMA in transient transfection experiments.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "name") (:form . "named") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 49)\n  (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 64)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 96)\n  (:start . 86) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 118)\n  (:start . 110) (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 135)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 148)\n  (:start . 136) (:id . 67))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 160)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1138.3) (:did . :|9414129|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010593@unknown@formal@none@1@S@We describe here a heterodimeric binding complex of NF-kappaB subunits (c-Rel and p65) which is identical to the one obtained using the HIV-LTR-kappaB site as recognition sequence and different from the one (c-Rel and p50) observed with nuclear extracts from Mo T-lymphoid HTLV-II infected cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . 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"infected") (:end . 289)\n  (:start . 281) (:id . 89))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 295)\n  (:start . 290) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s1138.4) (:did . :|9414129|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010594@unknown@formal@none@1@S@Cyclosporin A inhibits monocyte tissue factor activation in cardiac transplant recipients.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cardiac") (:form . "cardiac") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1139.1) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010595@unknown@formal@none@1@S@BACKGROUND: Fibrin deposition and thrombosis have been implicated in both allograft rejection and vasculopathy after cardiac transplantation.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Fibrin") (:form . "Fibrin") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "deposition") (:form . "deposition") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thrombosis") (:form . "thrombosis") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "allograft") (:form . "allograft") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "vasculopathy") (:form . "vasculopathy") (:end . 110)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 116)\n  (:start . 111) (:id . 57))\n ((:tag . "JJ") (:stem . "cardiac") (:form . "cardiac") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 140) (:start . 125) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1139.2) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010596@unknown@formal@none@1@S@Because monocytes play a pivotal role in the pathophysiology of intravascular coagulation activation through their ability to synthesize tissue factor (TF), we asked (1) whether monocyte TF activation occurs in cardiac transplant recipients and (2) whether monocyte TF expression is affected by treatment with cyclosporin A (CsA).@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . 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5010597@unknown@formal@none@1@S@METHODS AND RESULTS: We measured levels of TF activity in peripheral blood mononuclear cells and highly purified monocytes/macrophages from 10 consecutive cardiac transplant recipients and 10 healthy control subjects.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "AND") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 134) (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "consecutive") (:form . "consecutive") (:end . 154)\n  (:start . 143) (:id . 63))\n ((:tag . "JJ") (:stem . "cardiac") (:form . "cardiac") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 184)\n  (:start . 174) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 67))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 191) (:start . 189)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 199)\n  (:start . 192) (:id . 69))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 207)\n  (:start . 200) (:id . 70))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 216)\n  (:start . 208) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1139.4) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010598@unknown@formal@none@1@S@TF activity generated by both unstimulated and endotoxin-stimulated cells was significantly higher in transplant recipients than in control subjects (P<.05).@(((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "endotoxin-stimulated")\n  (:form . "endotoxin-stimulated") (:end . 67) (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 91) (:start . 78) (:id . 52))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 98) (:start . 92)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 112)\n  (:start . 102) (:id . 55))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 123)\n  (:start . 113) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 128) (:start . 124)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "control") (:form . "control") (:end . 139)\n  (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 148)\n  (:start . 140) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "P<.05") (:form . "P<.05") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1139.5) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010600@unknown@formal@none@1@S@Inhibition of TF induction in the presence of high CsA blood concentrations was also observed when stimulation of cells was performed with interferon-gamma or interleukin-1beta.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 75) (:start . 61) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 155) (:start . 139) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 176) (:start . 159) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1139.7) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010601@unknown@formal@none@1@S@As shown by reverse transcription-polymerase chain reaction and electrophoretic mobility shift assay, respectively, treatment with CsA leads to decreased TF mRNA expression and reduced activation of the NF-kappaB transcription factor, which is known to contribute to the induction of the TF promotor in human monocytes.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "transcription-polymerase")\n  (:form . "transcription-polymerase") (:end . 44) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reaction") (:form . 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5010602@unknown@formal@none@1@S@CONCLUSIONS: This study demonstrates that TF activation, occurring in mononuclear cells of cardiac transplant recipients, is inhibited by treatment with CsA.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "This") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cardiac") (:form . "cardiac") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "NNS") (:stem . "recipient") (:form . "recipients") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 156) (:start . 153)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1139.9) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010603@unknown@formal@none@1@S@Inhibition of monocyte TF induction by CsA may contribute to its successful use in cardiac transplant medicine and might be useful in managing further settings of vascular pathology also known to involve TF expression and NF-kappaB activation.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cardiac") (:form . "cardiac") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "transplant") (:form . "transplant") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "medicine") (:form . "medicine") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "manage") (:form . "managing") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "NN") (:stem . "pathology") (:form . "pathology") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 192)\n  (:start . 187) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 203)\n  (:start . 196) (:id . 73))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 217)\n  (:start . 207) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 231)\n  (:start . 222) (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 242)\n  (:start . 232) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1139.10.1) (:span 115 120))\n  ((:id . :x1139.10.2) (:span 43 46)))\n (:hscopes ((:id . :x1139.10.1) (:span 115 242))\n  ((:id . :x1139.10.2) (:span 43 110)))\n (:identifiers (:sid . :s1139.10) (:did . :|9416887|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010604@unknown@formal@none@1@S@Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.@(((:tag . "JJ") (:stem . "agonistic") (:form . "Agonistic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cd40-specific") (:form . "CD40-specific")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "single-chain") (:form . "single-chain") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "NNP") (:stem . "Fv") (:form . "Fv") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 65)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "g28-5") (:form . "G28-5") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1140.1) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010605@unknown@formal@none@1@S@A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "single-chain") (:form . "single-chain") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "Fv") (:form . "Fv") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "sFv") (:form . "sFv") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 37)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd40-specific") (:form . "CD40-specific")\n  (:end . 84) (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "g28-5") (:form . "G28-5") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1140.2) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010606@unknown@formal@none@1@S@The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2.2") (:form . "2.2") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "nM") (:form . "nM") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 56))\n ((:tag . "NN") (:stem . "monomer") (:form . "monomer") (:end . 71)\n  (:start . 64) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 83)\n  (:start . 75) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1140.3) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010607@unknown@formal@none@1@S@Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crosslinked CD40 on the cell surface but did not crosslink CD40-Ig in solution.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "G28-5") (:form . "G28-5") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "sFv") (:form . "sFv") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "VBD") (:stem . "crosslinke") (:form . "crosslinked") (:end . 74)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "VB") (:stem . "crosslink") (:form . "crosslink") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "cd40-ig") (:form . "CD40-Ig") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1140.4.1) (:span 108 111)))\n (:nscopes ((:id . :x1140.4.1) (:span 108 141)))\n (:identifiers (:sid . :s1140.4) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010608@unknown@formal@none@1@S@G28-5 sFv was a more potent agonist than G28-5 IgG and was able to stimulate CD40 responses by B cells and monocytes.@(((:tag . "NNP") (:stem . "G28-5") (:form . "G28-5") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "sFv") (:form . "sFv") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "agonist") (:form . "agonist") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "G28-5") (:form . "G28-5") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "VB") (:stem . "stimulate") (:form . "stimulate") (:end . 76)\n  (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 91)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 116)\n  (:start . 107) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1140.5) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010610@unknown@formal@none@1@S@These results indicate that the functional activity of ligands built from the binding site of G28-5 is highly dependent upon the size and physical properties of the molecule both in solution and on the cell surfaces.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "build") (:form . "built") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "G28-5") (:form . "G28-5") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 133) (:start . 129)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 157)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 173)\n  (:start . 165) (:id . 69))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 190)\n  (:start . 182) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 206) (:start . 202)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 215)\n  (:start . 207) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1140.7.1) (:span 14 27)))\n (:hscopes ((:id . :x1140.7.1) (:span 14 215)))\n (:identifiers (:sid . :s1140.7) (:did . :|9419430|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010611@unknown@formal@none@1@S@Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay.@(((:tag . "JJ") (:stem . "competent") (:form . "Competent") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 34)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "xeroderma") (:form . "xeroderma") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "pigmentosum") (:form . "pigmentosum") (:end . 104)\n  (:start . 93) (:id . 54))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 111)\n  (:start . 105) (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "optimize") (:form . "optimized") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 153) (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1141.1) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010612@unknown@formal@none@1@S@The human autosomal recessive disease, xeroderma pigmentosum (XP), can result from mutations in any one of seven genes, designated XPA through XPG.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "autosomal") (:form . "autosomal") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "recessive") (:form . "recessive") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "xeroderma") (:form . "xeroderma") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "pigmentosum") (:form . "pigmentosum") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "XP") (:form . "XP") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 130)\n  (:start . 120) (:id . 65))\n ((:tag . "NNP") (:stem . "XPA") (:form . "XPA") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 142)\n  (:start . 135) (:id . 67))\n ((:tag . "NNP") (:stem . "XPG") (:form . "XPG") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1141.2) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010613@unknown@formal@none@1@S@Of these, the XPB and XPD genes encode proteins that are subunits of a general transcription factor, TFIIH, involved in both nucleotide excision repair (NER) and initiation of mRNA transcription by RNA polymerase II.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "XPD") (:form . "XPD") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 31) (:start . 26)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 38)\n  (:start . 32) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 92) (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TFIIH") (:form . "TFIIH") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 116)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 135)\n  (:start . 125) (:id . 66))\n ((:tag . "NN") (:stem . "excision") (:form . "excision") (:end . 144)\n  (:start . 136) (:id . 67))\n ((:tag . "NN") (:stem . "repair") (:form . "repair") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NER") (:form . "NER") (:end . 156) (:start . 153)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 72))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 172)\n  (:start . 162) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 74))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 180) (:start . 176)\n  (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 194) (:start . 181) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 197) (:start . 195)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 201) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 212)\n  (:start . 202) (:id . 79))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 215) (:start . 213)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1141.3) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010614@unknown@formal@none@1@S@In humans, mutation of the XPB or XPD gene impairs NER, resulting in hyper-sensitivity to sunlight and greatly increased skin tumor formation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "XPB") (:form . "XPB") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "XPD") (:form . "XPD") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 50)\n  (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "ner") (:form . "NER") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 65)\n  (:start . 56) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hyper-sensitivity") (:form . "hyper-sensitivity")\n  (:end . 86) (:start . 69) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sunlight") (:form . "sunlight") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 120)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "skin") (:form . "skin") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 141)\n  (:start . 132) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1141.4) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010615@unknown@formal@none@1@S@However, no transcription deficiency has been demonstrated in either XP-B or XP-D.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "XP-B") (:form . "XP-B") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "XP-D") (:form . "XP-D") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1141.5.1) (:span 9 11)))\n (:nscopes ((:id . :x1141.5.1) (:span 9 81)))\n (:identifiers (:sid . :s1141.5) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010616@unknown@formal@none@1@S@We have employed an optimized cell-free RNA transcription assay to analyze transcription activity of XP-B and XP-D.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "optimize") (:form . "optimized") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "XP-B") (:form . "XP-B") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "XP-D") (:form . "XP-D") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1141.6) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010617@unknown@formal@none@1@S@Although the growth rate was normal, the XP-B and XP-D cells contained reduced amounts of TFIIH.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "XP-B") (:form . "XP-B") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "XP-D") (:form . "XP-D") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "TFIIH") (:form . "TFIIH") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1141.7) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010618@unknown@formal@none@1@S@Extracts prepared from XP-B and XP-D lymphoblastoid cells exhibited similar transcription activity from the adenovirus major late promoter when compared to that in extracts from normal cells.@(((:tag . "NNS") (:stem . "extract") (:form . "Extracts") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "XP-B") (:form . "XP-B") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "XP-D") (:form . "XP-D") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 51) (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 89) (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adenovirus") (:form . "adenovirus") (:end . 118)\n  (:start . 108) (:id . 56))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 124)\n  (:start . 119) (:id . 57))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 138)\n  (:start . 130) (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 155) (:start . 153)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 160) (:start . 156)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 172)\n  (:start . 164) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 177) (:start . 173)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 184)\n  (:start . 178) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 190)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1141.8) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010620@unknown@formal@none@1@S@We consider the possible consequences of the reduced cellular content of TFIIH for the clinical symptoms in XP-B or XP-D patients, and discuss a 'conditional phenotype' that may involve an impairment of cellular function only under certain growth conditions.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TFIIH") (:form . "TFIIH") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "symptom") (:form . "symptoms") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "XP-B") (:form . "XP-B") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "XP-D") (:form . "XP-D") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "discuss") (:form . "discuss") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "'conditional") (:form . "'conditional") (:end . 157)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . "''") (:stem . "'") (:form . "'") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 185)\n  (:start . 178) (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "impairment") (:form . "impairment") (:end . 199)\n  (:start . 189) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 211)\n  (:start . 203) (:id . 76))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 220)\n  (:start . 212) (:id . 77))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 225) (:start . 221)\n  (:id . 78))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 231)\n  (:start . 226) (:id . 79))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 239)\n  (:start . 232) (:id . 80))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 246)\n  (:start . 240) (:id . 81))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 257)\n  (:start . 247) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1141.10.1) (:span 174 177))\n  ((:id . :x1141.10.2) (:span 16 24)))\n (:hscopes ((:id . :x1141.10.1) (:span 174 257))\n  ((:id . :x1141.10.2) (:span 16 129)))\n (:identifiers (:sid . :s1141.10) (:did . :|9427533|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010621@unknown@formal@none@1@S@Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "g0s2") (:form . "G0S2") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 98) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1142.1) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010622@unknown@formal@none@1@S@Cyclosporin A (CsA) may achieve its immunosuppressive effects by inhibiting the calcium- and calmodulin-dependent phosphatase calcineurin which is required for activation of target genes by members of the NFAT (nuclear factor of activated T cells) transcription factor family.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 53) (:start . 36) (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "calcium-") (:form . "calcium-") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "calmodulin-dependent")\n  (:form . "calmodulin-dependent") (:end . 113) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "calcineurin") (:form . "calcineurin") (:end . 137)\n  (:start . 126) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 143)\n  (:start . 138) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 65))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 180)\n  (:start . 174) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 186)\n  (:start . 181) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 189) (:start . 187)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 197)\n  (:start . 190) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 209) (:start . 205)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 218)\n  (:start . 211) (:id . 74))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 225)\n  (:start . 219) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 238)\n  (:start . 229) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 240) (:start . 239)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 246)\n  (:start . 241) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 247) (:start . 246)\n  (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 261) (:start . 248) (:id . 81))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 268)\n  (:start . 262) (:id . 82))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 275)\n  (:start . 269) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1142.2.1) (:span 20 23)))\n (:hscopes ((:id . :x1142.2.1) (:span 20 275)))\n (:identifiers (:sid . :s1142.2) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010623@unknown@formal@none@1@S@Among these target genes is the gene encoding interleukin-2 (IL2), a cytokine facilitating progression through the G1 phase of the cell cycle.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IL2") (:form . "IL2") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "VBG") (:stem . "facilitate") (:form . "facilitating") (:end . 90)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1142.3) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010624@unknown@formal@none@1@S@However, IL2 does not reverse CsA inhibition, suggesting that at least one other NFAT-sensitive gene may be involved.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "IL2") (:form . "IL2") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "reverse") (:form . "reverse") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nfat-sensitive") (:form . "NFAT-sensitive")\n  (:end . 95) (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1142.4.1) (:span 101 104))\n  ((:id . :x1142.4.2) (:span 46 56)))\n (:ncues ((:id . :x1142.4.3) (:span 18 21)))\n (:hscopes ((:id . :x1142.4.1) (:span 62 116))\n  ((:id . :x1142.4.2) (:span 46 116)))\n (:nscopes ((:id . :x1142.4.3) (:span 18 44)))\n (:identifiers (:sid . :s1142.4) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010625@unknown@formal@none@1@S@The human G0/G1 switch gene, G0S2, has potential NFAT-binding sites in the 5' flank and encodes a small basic potential phosphoprotein of unknown function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "g0/g1") (:form . "G0/G1") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "G0S2") (:form . "G0S2") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 48)\n  (:start . 39) (:id . 51))\n ((:tag . "JJ") (:stem . "nfat-binding") (:form . "NFAT-binding") (:end . 61)\n  (:start . 49) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "flank") (:form . "flank") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 103) (:start . 98)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 109)\n  (:start . 104) (:id . 63))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 119)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "phosphoprotein") (:form . "phosphoprotein")\n  (:end . 134) (:start . 120) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1142.5.1) (:span 138 145))\n  ((:id . :x1142.5.2) (:span 110 119)) ((:id . :x1142.5.3) (:span 39 48)))\n (:hscopes ((:id . :x1142.5.1) (:span 138 154))\n  ((:id . :x1142.5.2) (:span 110 154)) ((:id . :x1142.5.3) (:span 39 83)))\n (:identifiers (:sid . :s1142.5) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010626@unknown@formal@none@1@S@Using a sensitive, reverse transcription-polymerase chain reaction (RT-PCR) assay, G0S2 mRNA levels were assayed in cultured blood mononuclear cells.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "transcription-polymerase")\n  (:form . "transcription-polymerase") (:end . 51) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "g0s2") (:form . "G0S2") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1142.6) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010627@unknown@formal@none@1@S@Freshly isolated cells contain high levels of G0S2 mRNA which rapidly decline.@(((:tag . "RB") (:stem . "freshly") (:form . "Freshly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "g0s2") (:form . "G0S2") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBP") (:stem . "decline") (:form . "decline") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1142.7) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010628@unknown@formal@none@1@S@This "spontaneous stimulation" is also noted with some other G0S genes and has been attributed to some aspect of the isolation procedure.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "\\"spontaneous") (:form . "\\"spontaneous")\n  (:end . 17) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "G0S") (:form . "G0S") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "aspect") (:form . "aspect") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "isolation") (:form . "isolation") (:end . 126)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1142.8) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010630@unknown@formal@none@1@S@Both these responses are inhibited by CsA.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1142.10) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010631@unknown@formal@none@1@S@Our results suggest that G0S2 expression is required to commit cells to enter the G1 phase of the cell cycle, and that, while not excluding other possible targets, early inhibition of G0S2 expression by CsA may be important in achieving immunosuppression.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "g0s2") (:form . "G0S2") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "commit") (:form . "commit") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "enter") (:form . "enter") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "g1") (:form . "G1") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 125)\n  (:start . 120) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 129) (:start . 126)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 139)\n  (:start . 130) (:id . 68))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 145)\n  (:start . 140) (:id . 69))\n ((:tag . "JJ") (:stem . "possible") (:form . 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"may") (:end . 210) (:start . 207)\n  (:id . 80))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 213) (:start . 211)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 223)\n  (:start . 214) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 83))\n ((:tag . "VBG") (:stem . "achieve") (:form . "achieving") (:end . 236)\n  (:start . 227) (:id . 84))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 254) (:start . 237) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x1142.11.1) (:span 207 210))\n  ((:id . :x1142.11.2) (:span 146 154)) ((:id . :x1142.11.4) (:span 12 19)))\n (:ncues ((:id . :x1142.11.3) (:span 126 129)))\n (:hscopes ((:id . :x1142.11.1) (:span 207 254))\n  ((:id . :x1142.11.2) (:span 146 162)) ((:id . :x1142.11.4) (:span 12 254)))\n (:nscopes ((:id . :x1142.11.3) (:span 126 162)))\n (:identifiers (:sid . :s1142.11) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010632@unknown@formal@none@1@S@G0S2 may be of value as a reporter gene for analyzing the mechanism of action of CsA and its influence on the positive and negative selection of lymphocytes in response to self and not-self antigens.@(((:tag . "NNP") (:stem . "G0S2") (:form . "G0S2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 34)\n  (:start . 26) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "analyze") (:form . "analyzing") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 102)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 118)\n  (:start . 110) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 131)\n  (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 156)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "self") (:form . "self") (:end . 176) (:start . 172)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "not-self") (:form . "not-self") (:end . 189)\n  (:start . 181) (:id . 75))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 198)\n  (:start . 190) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1142.12.1) (:span 5 8)))\n (:hscopes ((:id . :x1142.12.1) (:span 5 198)))\n (:identifiers (:sid . :s1142.12) (:did . :|9428793|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010633@unknown@formal@none@1@S@Estrogen receptor diminishes DNA-binding activities of chicken GATA-1 and CACCC-binding proteins.@(((:tag . "NNP") (:stem . "Estrogen") (:form . "Estrogen") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "diminish") (:form . "diminishes") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 40)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 51)\n  (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 69)\n  (:start . 63) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "caccc-binding") (:form . "CACCC-binding")\n  (:end . 87) (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1143.1) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010634@unknown@formal@none@1@S@The estrogen receptor (ER) repressed erythroid differentiation and erythroid-specific gene expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "repress") (:form . "repressed") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 85) (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1143.2) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010635@unknown@formal@none@1@S@In this study, we investigated the effect of ER alpha (referred to throughout as ER) on DNA-binding activities of transcription factors involved in regulating the expression of erythroid-specific genes, and, in particular, the histone H5 gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 77)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 83) (:start . 81)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 99)\n  (:start . 88) (:id . 61))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 110)\n  (:start . 100) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 64))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 158)\n  (:start . 148) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 195) (:start . 177) (:id . 72))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 201)\n  (:start . 196) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 221)\n  (:start . 211) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 80))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 234)\n  (:start . 227) (:id . 81))\n ((:tag . "NN") (:stem . "h5") (:form . "H5") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 242) (:start . 238)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1143.3) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010636@unknown@formal@none@1@S@Using electrophoretic mobility shift assays, we found that in the presence of rabbit reticulocyte lysate, human ER reduced the binding activities of chicken immature erythrocyte nuclear extracted proteins to GATA and CACCC sites in the H5 promoter and enhancer.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 97)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 156)\n  (:start . 149) (:id . 66))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "erythrocyte") (:form . "erythrocyte") (:end . 177)\n  (:start . 166) (:id . 68))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "JJ") (:stem . "extracted") (:form . "extracted") (:end . 195)\n  (:start . 186) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 204)\n  (:start . 196) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 207) (:start . 205)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 212) (:start . 208)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "CACCC") (:form . "CACCC") (:end . 222)\n  (:start . 217) (:id . 75))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 228)\n  (:start . 223) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 231) (:start . 229)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "H5") (:form . "H5") (:end . 238) (:start . 236)\n  (:id . 79))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 247)\n  (:start . 239) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 251) (:start . 248)\n  (:id . 81))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 260)\n  (:start . 252) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1143.4) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010637@unknown@formal@none@1@S@In contrast, the binding activities of NF1 and Sp1 were not affected by ER.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF1") (:form . "NF1") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ER") (:form . "ER") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1143.5.1) (:span 56 59)))\n (:nscopes ((:id . :x1143.5.1) (:span 13 74)))\n (:identifiers (:sid . :s1143.5) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010638@unknown@formal@none@1@S@Binding of ER to an estrogen response element was enhanced by addition of rabbit reticulocyte lysate.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "estrogen") (:form . "estrogen") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "reticulocyte") (:form . "reticulocyte") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "lysate") (:form . "lysate") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1143.6) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010640@unknown@formal@none@1@S@These results suggest that additional factor(s) are necessary for full ER function.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "factor(s)") (:form . "factor(s)") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x1143.8.1) (:span 14 21)))\n (:hscopes ((:id . :x1143.8.1) (:span 14 82)))\n (:identifiers (:sid . :s1143.8) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010641@unknown@formal@none@1@S@Both GATA-1 and CACCC-binding proteins are critical for the developmentally regulated expression of erythroid-specific genes.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "caccc-binding") (:form . "CACCC-binding")\n  (:end . 29) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 75) (:start . 60) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 118) (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 124)\n  (:start . 119) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1143.9) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010642@unknown@formal@none@1@S@We hypothesize that interference in DNA-binding activities of GATA-1 and CACCC-binding proteins is the mechanism by which the ER inhibits regulation of these genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "hypothesize") (:form . "hypothesize") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gata-1") (:form . "GATA-1") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "caccc-binding") (:form . "CACCC-binding")\n  (:end . 86) (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "er") (:form . "ER") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 148)\n  (:start . 138) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1143.10.1) (:span 3 14)))\n (:hscopes ((:id . :x1143.10.1) (:span 3 163)))\n (:identifiers (:sid . :s1143.10) (:did . :|9428796|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010643@unknown@formal@none@1@S@Constitutive expression c-fos, c-jun, and NF kappa B mRNA is in nucleated fetal blood cells and up-regulation of c-fos and c-jun with anti-CD3 stimulation.@(((:tag . "JJ") (:stem . "constitutive") (:form . "Constitutive") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 29) (:start . 24)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nucleated") (:form . "nucleated") (:end . 73)\n  (:start . 64) (:id . 55))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 79) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 109) (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 154)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1144.1) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010644@unknown@formal@none@1@S@Fetal and neonatal lymphocytes are relatively resistant to activation and cytokine production when stimulated either via their T-cell antigen receptors or lectins.@(((:tag . "JJ") (:stem . "fetal") (:form . "Fetal") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 109)\n  (:start . 99) (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 116)\n  (:start . 110) (:id . 56))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 133)\n  (:start . 127) (:id . 59))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 141)\n  (:start . 134) (:id . 60))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lectin") (:form . "lectins") (:end . 162)\n  (:start . 155) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1144.2) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010645@unknown@formal@none@1@S@The molecular mechanism(s) responsible for this phenomenon have not been clearly elucidated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "mechanism(s)") (:form . "mechanism(s)") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 38)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "VBN") (:stem . "elucidate") (:form . "elucidated") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x1144.3.1) (:span 64 91)))\n (:hscopes ((:id . :x1144.3.1) (:span 0 91)))\n (:identifiers (:sid . :s1144.3) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010646@unknown@formal@none@1@S@We have hypothesized that such defects in fetal/neonatal T-cell activation may be due to lack of expression of the transcriptional regulatory elements required for T-cell activation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "hypothesize") (:form . "hypothesized") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fetal/neonatal") (:form . "fetal/neonatal")\n  (:end . 56) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 130) (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 150)\n  (:start . 142) (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 181)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1144.4.2) (:span 75 78)) ((:id . :x1144.4.3) (:span 8 20)))\n (:ncues ((:id . :x1144.4.1) (:span 89 93)))\n (:hscopes ((:id . :x1144.4.2) (:span 75 181))\n  ((:id . :x1144.4.3) (:span 8 181)))\n (:nscopes ((:id . :x1144.4.1) (:span 89 181)))\n (:identifiers (:sid . :s1144.4) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010647@unknown@formal@none@1@S@We used reverse transcriptase-polymerase chain reaction to examine both fetal and term neonatal cord bloods for mRNA expression of three transcription factors implicated in T-cell activation: c-jun, c-fos, and NF kappa B (p50 subunit).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 40) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 71) (:start . 67)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "blood") (:form . "bloods") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 150) (:start . 137) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 158)\n  (:start . 151) (:id . 63))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 179)\n  (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 190)\n  (:start . 180) (:id . 67))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 191) (:start . 190)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 197)\n  (:start . 192) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 198) (:start . 197)\n  (:id . 70))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 204)\n  (:start . 199) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 212) (:start . 210)\n  (:id . 74))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 218)\n  (:start . 213) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 220) (:start . 219)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 222) (:start . 221)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 233)\n  (:start . 226) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1144.5) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010648@unknown@formal@none@1@S@We demonstrate that mRNAs for all three of these regulatory factors are expressed in fetal blood cells by the 27th week of gestation and in term cord bloods.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "27th") (:form . "27th") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "week") (:form . "week") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "gestation") (:form . "gestation") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "term") (:form . "term") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "blood") (:form . "bloods") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1144.6) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010650@unknown@formal@none@1@S@However, secretion of IL-2 by anti-CD3-stimulated cord blood mononuclear cells was still blunted compared with control cells from adults.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-cd3-stimulated")\n  (:form . "anti-CD3-stimulated") (:end . 49) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "cord") (:form . "cord") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 72)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "blunt") (:form . "blunted") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1144.8) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010651@unknown@formal@none@1@S@We conclude that fetal nucleated blood cells constitutively express important genes for cytokine regulation and are able to increase intracellular accumulation of the mRNAs for these factors in response to anti-CD3 stimulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nucleated") (:form . "nucleated") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 59) (:start . 45) (:id . 49))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 146) (:start . 133) (:id . 61))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 159)\n  (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 182)\n  (:start . 177) (:id . 67))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 190)\n  (:start . 183) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 69))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 202)\n  (:start . 194) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 205) (:start . 203)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 214)\n  (:start . 206) (:id . 72))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 226)\n  (:start . 215) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1144.9) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010652@unknown@formal@none@1@S@Thus, qualitative differences in the capacity to regulate these factors could not be shown in fetal blood cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "qualitative") (:form . "qualitative") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1144.10.1) (:span 78 81)))\n (:nscopes ((:id . :x1144.10.1) (:span 6 111)))\n (:identifiers (:sid . :s1144.10) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010653@unknown@formal@none@1@S@Quantitative experiments comparing binding of these transcription factors to the IL-2 promoter are currently under investigation.@(((:tag . "JJ") (:stem . "quantitative") (:form . "Quantitative") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 34)\n  (:start . 25) (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 51) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 73)\n  (:start . 66) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 85) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 98) (:start . 95)\n  (:id . 54))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 108)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 128) (:start . 115) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1144.11) (:did . :|9428992|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010654@unknown@formal@none@1@S@Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation.@(((:tag . "NNP") (:stem . "Replication") (:form . "Replication") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 37) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "virus-1") (:form . "virus-1") (:end . 45)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 179)\n  (:start . 167) (:id . 67))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 192)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1145.1) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010655@unknown@formal@none@1@S@Tumor necrosis factor (TNF)-alpha controls T-cell activation and is a major inducer of human immunodeficiency virus (HIV)-1 replication in chronically infected cells.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF)-alpha") (:form . "TNF)-alpha") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inducer") (:form . "inducer") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 109) (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "HIV)-1") (:form . "HIV)-1") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 150)\n  (:start . 139) (:id . 63))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1145.2) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010656@unknown@formal@none@1@S@Therefore, we have investigated its role in primary cultures of HIV-infected human T lymphocytes by using neutralizing anti-TNF-alpha antibodies or TNF-alpha.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 105) (:start . 100)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 118)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "anti-tnf-alpha") (:form . "anti-TNF-alpha")\n  (:end . 133) (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 157)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1145.3) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010657@unknown@formal@none@1@S@Primary resting T lymphocytes produced TNF-alpha and supported HIV replication after T-cell receptor activation.@(((:tag . "JJ") (:stem . "primary") (:form . "Primary") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 15) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "support") (:form . "supported") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1145.4) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010658@unknown@formal@none@1@S@Addition of neutralizing anti-TNF-alpha antibodies drastically reduced p24 antigen release and prevented CD4+ cell depletion associated with infection.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "neutralize") (:form . "neutralizing") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "JJ") (:stem . "anti-tnf-alpha") (:form . "anti-TNF-alpha")\n  (:end . 39) (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "RB") (:stem . "drastically") (:form . "drastically") (:end . 62)\n  (:start . 51) (:id . 47))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 70)\n  (:start . 63) (:id . 48))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 74) (:start . 71)\n  (:id . 49))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 82)\n  (:start . 75) (:id . 50))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 90)\n  (:start . 83) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 104)\n  (:start . 95) (:id . 53))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 109) (:start . 105)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 55))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 124)\n  (:start . 115) (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 135)\n  (:start . 125) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 58))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 150)\n  (:start . 141) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1145.5) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010660@unknown@formal@none@1@S@Moreover, supplementing the cultures with high doses of IL-2 reverted anti-TNF-alpha inhibition of cell proliferation but did not affect the inhibition of HIV p24 antigen release or NF-kappa B activation in the same cultures.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "VBG") (:stem . "supplement") (:form . "supplementing") (:end . 23)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "dose") (:form . "doses") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "revert") (:form . "reverted") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "anti-tnf-alpha") (:form . "anti-TNF-alpha")\n  (:end . 84) (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 117) (:start . 104) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 136)\n  (:start . 130) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 151)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "p24") (:form . "p24") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 170)\n  (:start . 163) (:id . 67))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 190)\n  (:start . 182) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 192) (:start . 191)\n  (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 203)\n  (:start . 193) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 215) (:start . 211)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 224)\n  (:start . 216) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x1145.7.1) (:span 126 129)))\n (:nscopes ((:id . :x1145.7.1) (:span 126 224)))\n (:identifiers (:sid . :s1145.7) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5010662@unknown@formal@none@1@S@Our results support an important role for autocrine TNF-alpha secretion in controlling HIV replication in primary T cells because of its ability to maintain NF-kappa B elevated in the nucleus of T cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 102)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 167) (:start . 166)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1145.9) (:did . :|9438495|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010663@unknown@formal@none@1@S@A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 101) (:start . 88) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1146.1) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010664@unknown@formal@none@1@S@The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 11) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 139)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 151)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 167) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 174)\n  (:start . 168) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 186)\n  (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 200)\n  (:start . 190) (:id . 75))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 214)\n  (:start . 205) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 217) (:start . 215)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 223)\n  (:start . 218) (:id . 79))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 225) (:start . 224)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 231)\n  (:start . 226) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1146.2.1) (:span 155 162)))\n (:hscopes ((:id . :x1146.2.1) (:span 155 231)))\n (:identifiers (:sid . :s1146.2) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010665@unknown@formal@none@1@S@Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DND39") (:form . "DND39") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DG75") (:form . "DG75") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1146.3) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010666@unknown@formal@none@1@S@In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "n-acetyl-l-cysteine")\n  (:form . "n-acetyl-L-cysteine") (:end . 39) (:start . 20) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 55)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "thiol") (:form . "thiol") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 73)\n  (:start . 62) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 99)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 138)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 163)\n  (:start . 154) (:id . 70))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 174)\n  (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 183)\n  (:start . 175) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1146.4) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010667@unknown@formal@none@1@S@Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 143)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "decoy") (:form . "decoy") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "NNS") (:stem . "oligodeoxynucleotide")\n  (:form . "oligodeoxynucleotides") (:end . 174) (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 202) (:start . 198)\n  (:id . 72))\n ((:tag . "RB") (:stem . "partly") (:form . "partly") (:end . 209)\n  (:start . 203) (:id . 73))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 217)\n  (:start . 210) (:id . 74))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 230)\n  (:start . 218) (:id . 75))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 239)\n  (:start . 231) (:id . 76))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 248)\n  (:start . 240) (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 262) (:start . 249) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1146.5) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010668@unknown@formal@none@1@S@However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "decoy") (:form . "decoy") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "oligodeoxynucleotide")\n  (:form . "oligodeoxynucleotides") (:end . 46) (:start . 25) (:id . 47))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 62)\n  (:start . 56) (:id . 49))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 73)\n  (:start . 63) (:id . 50))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 83)\n  (:start . 74) (:id . 51))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 96)\n  (:start . 84) (:id . 52))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 105)\n  (:start . 97) (:id . 53))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 114)\n  (:start . 106) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1146.6) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010670@unknown@formal@none@1@S@The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "deletional") (:form . "deletional") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "isotype") (:form . "isotype") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1146.8) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010671@unknown@formal@none@1@S@NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody.@(((:tag . "NNP") (:stem . "NAC") (:form . "NAC") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Smu/Sepsilon") (:form . "Smu/Sepsilon") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "costimulate") (:form . "costimulated") (:end . 98)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 122)\n  (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1146.9) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010672@unknown@formal@none@1@S@It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "il-4-induced") (:form . "IL-4-induced") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 77)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD23") (:form . "CD23") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1146.10) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010673@unknown@formal@none@1@S@These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "coordination") (:form . "coordination") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 159) (:start . 146) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 187) (:start . 185)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 197)\n  (:start . 188) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 211)\n  (:start . 201) (:id . 72))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 216) (:start . 212)\n  (:id . 73))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 228)\n  (:start . 217) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 231) (:start . 229)\n  (:id . 75))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 240)\n  (:start . 232) (:id . 76))\n ((:tag . "NNP") (:stem . "Cepsilon") (:form . "Cepsilon") (:end . 249)\n  (:start . 241) (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 263) (:start . 250) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 267) (:start . 264)\n  (:id . 79))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 273)\n  (:start . 268) (:id . 80))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 283)\n  (:start . 274) (:id . 81))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 286) (:start . 284)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 290) (:start . 287)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 291) (:start . 290)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1146.11.1) (:span 181 184))\n  ((:id . :x1146.11.2) (:span 63 66)) ((:id . :x1146.11.3) (:span 14 21)))\n (:hscopes ((:id . :x1146.11.1) (:span 181 290))\n  ((:id . :x1146.11.2) (:span 27 135)) ((:id . :x1146.11.3) (:span 14 290)))\n (:identifiers (:sid . :s1146.11) (:did . :|9440542|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010674@unknown@formal@none@1@S@Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "allergen-specific")\n  (:end . 102) (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1147.1) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010675@unknown@formal@none@1@S@BACKGROUND: Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokines") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "intimately") (:form . "intimately") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 143)\n  (:start . 131) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1147.2) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010676@unknown@formal@none@1@S@OBJECTIVE: We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma.@(((:tag . "NN") (:stem . "objective") (:form . "OBJECTIVE") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 112)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 147)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1147.3) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010677@unknown@formal@none@1@S@METHODS: Allergen-specific T cell clones and T cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the responses to various stimuli were determined.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "allergen-specific") (:form . "Allergen-specific")\n  (:end . 26) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 117)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 129)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 141)\n  (:start . 135) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 160)\n  (:start . 151) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 179)\n  (:start . 172) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 184) (:start . 180)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 195)\n  (:start . 185) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1147.4) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010678@unknown@formal@none@1@S@RESULTS: After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "after") (:form . "After") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nonspecific") (:form . "nonspecific") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-5") (:form . "IL-5") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonatopic") (:form . "nonatopic") (:end . 102)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 141) (:start . 128) (:id . 63))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 191)\n  (:start . 184) (:id . 71))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1147.5) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010680@unknown@formal@none@1@S@A human IL-5 promoter/enhancer luciferase gene construct transfected into IL-5-producing T cell clones was clearly transcribed after stimulation, indicating that the 515 base pair IL-5 gene segment upstream of the coding region was sufficient to respond to activating signals in human helper T cells.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "promoter/enhancer") (:form . "promoter/enhancer")\n  (:end . 30) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "construct") (:form . 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"respond") (:end . 253)\n  (:start . 246) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 256) (:start . 254)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 267)\n  (:start . 257) (:id . 80))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 275)\n  (:start . 268) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 278) (:start . 276)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 284)\n  (:start . 279) (:id . 83))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 291)\n  (:start . 285) (:id . 84))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 293) (:start . 292)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 299)\n  (:start . 294) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5010681@unknown@formal@none@1@S@The same gene segment was not transcribed in IL-5-nonproducing T cell clones, suggesting that human T cell IL-5 synthesis is regulated at the transcriptional level.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "il-5-nonproducing") (:form . "IL-5-nonproducing")\n  (:end . 62) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 157) (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 163)\n  (:start . 158) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1147.8.1) (:span 78 88)))\n (:ncues ((:id . :x1147.8.2) (:span 26 29)))\n (:hscopes ((:id . :x1147.8.1) (:span 78 163)))\n (:nscopes ((:id . :x1147.8.2) (:span 0 76)))\n (:identifiers (:sid . :s1147.8) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010682@unknown@formal@none@1@S@Experiments with T cell hybridomas confirmed these findings and suggested that a unique transcription factor may be essential for human IL-5 gene transcription.@(((:tag . "NNS") (:stem . "experiment") (:form . "Experiments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 101) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 159) (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1147.9.1) (:span 109 112))\n  ((:id . :x1147.9.2) (:span 64 73)))\n (:hscopes ((:id . :x1147.9.1) (:span 109 159))\n  ((:id . :x1147.9.2) (:span 64 159)))\n (:identifiers (:sid . :s1147.9) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010683@unknown@formal@none@1@S@CONCLUSION: Enhanced IL-5 production by helper T cells seems to cause the eosinophilic inflammation of both atopic and nonatopic asthma.@(((:tag . "NN") (:stem . "conclusion") (:form . "CONCLUSION") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "enhance") (:form . "Enhanced") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "il-5") (:form . "IL-5") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "atopic") (:form . "atopic") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nonatopic") (:form . "nonatopic") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1147.10.1) (:span 55 60)))\n (:hscopes ((:id . :x1147.10.1) (:span 12 135)))\n (:identifiers (:sid . :s1147.10) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010684@unknown@formal@none@1@S@Elucidation of IL-5-specific regulatory mechanisms may facilitate the development of novel treatments for allergic diseases associated with eosinophilic inflammation.@(((:tag . "NN") (:stem . "elucidation") (:form . "Elucidation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "il-5-specific") (:form . "IL-5-specific")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 39)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 50)\n  (:start . 40) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 65)\n  (:start . 55) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 81)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "treatment") (:form . "treatments") (:end . 101)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "allergic") (:form . "allergic") (:end . 114)\n  (:start . 106) (:id . 55))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 123)\n  (:start . 115) (:id . 56))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 134)\n  (:start . 124) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "eosinophilic") (:form . "eosinophilic") (:end . 152)\n  (:start . 140) (:id . 59))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 165)\n  (:start . 153) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1147.11.1) (:span 51 54)))\n (:hscopes ((:id . :x1147.11.1) (:span 51 165)))\n (:identifiers (:sid . :s1147.11) (:did . :|9440546|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010685@unknown@formal@none@1@S@Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 81)\n  (:start . 72) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1148.1) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010686@unknown@formal@none@1@S@Transcription factor NF-kappa B must be released from cytoplasmic inhibitory molecules (I kappa Bs) in order to move to the nucleus and to activate its target genes.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "b") (:form . "Bs") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "VB") (:stem . "move") (:form . "move") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 158)\n  (:start . 152) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1148.2) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010687@unknown@formal@none@1@S@Little is known about the mechanisms regulating the maintenance of constitutive nuclear NF-kappa B in some cell-types and of sustained nuclear NF-kappa B activity after stimulation.@(((:tag . "JJ") (:stem . "little") (:form . "Little") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 79)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell-type") (:form . "cell-types") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 162)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 168)\n  (:start . 163) (:id . 66))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 180)\n  (:start . 169) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1148.3) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010688@unknown@formal@none@1@S@Increased turnover has been implicated in the regulation of constitutive NF-kappa B activity in mature B cells.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 102)\n  (:start . 96) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1148.4) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010690@unknown@formal@none@1@S@Both proteins display a high turnover in B cells although I kappa B beta is considerably more stable than I kappa B alpha.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "RB") (:stem . "considerably") (:form . "considerably") (:end . 88)\n  (:start . 76) (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1148.6) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010691@unknown@formal@none@1@S@The half-life of both inhibitors is increased in HeLa cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "half-life") (:form . "half-life") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1148.7) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010692@unknown@formal@none@1@S@In contrast, all other NF-kappa B/I kappa B molecules tested are relatively stable in both cell-types.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "B/I") (:form . "B/I") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 60) (:start . 54)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell-type") (:form . "cell-types") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1148.8) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010693@unknown@formal@none@1@S@The elevated turnover of endogenous I kappa B alpha in Namalwa cells is inhibited by a proteasome inhibitor and thus seems to be driven by the same degradation machinery as the slower turnover in non-B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Namalwa") (:form . "Namalwa") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 135)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 159)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 169)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "JJR") (:stem . "slow") (:form . "slower") (:end . 183)\n  (:start . 177) (:id . 73))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 192)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "non-b") (:form . "non-B") (:end . 201)\n  (:start . 196) (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 207)\n  (:start . 202) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1148.9.1) (:span 117 122)))\n (:hscopes ((:id . :x1148.9.1) (:span 117 207)))\n (:identifiers (:sid . :s1148.9) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010694@unknown@formal@none@1@S@Furthermore, we investigated the processes involved in persistent activation of NF-kappa B.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "persistent") (:form . "persistent") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1148.10) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010695@unknown@formal@none@1@S@TNF-alpha signaling leads to a rapid depletion of cellular I kappa B beta pools.@(((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 25) (:start . 20)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pool") (:form . "pools") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1148.11) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010696@unknown@formal@none@1@S@I kappa B alpha is efficiently resynthesized whereas I kappa B beta levels stay low for a prolonged time.@(((:tag . "NN") (:stem . "i") (:form . "I") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "VBN") (:stem . "resynthesize") (:form . "resynthesized")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "VBP") (:stem . "stay") (:form . "stay") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "prolong") (:form . "prolonged") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1148.12) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010697@unknown@formal@none@1@S@NF-kappa B binding activity can be detected for several hours after stimulation.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 79)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1148.13) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010698@unknown@formal@none@1@S@We found that removal of the TNF-alpha containing medium causes a rapid decrease in nuclear NF-kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1148.14) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010700@unknown@formal@none@1@S@There is no significant difference in the turnover of pre- and post-inductive I kappa B alpha.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pre-") (:form . "pre-") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "post-inductive") (:form . "post-inductive")\n  (:end . 77) (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1148.16.1) (:span 9 11)))\n (:nscopes ((:id . :x1148.16.1) (:span 9 93)))\n (:identifiers (:sid . :s1148.16) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010701@unknown@formal@none@1@S@These observations suggest that resynthesis of I kappa B alpha and removal of the stimulus are obligatory steps for the inactivation of nuclear NF kappa B.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "resynthesis") (:form . "resynthesis") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "obligatory") (:form . "obligatory") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 132)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1148.17.1) (:span 19 26)))\n (:hscopes ((:id . :x1148.17.1) (:span 19 154)))\n (:identifiers (:sid . :s1148.17) (:did . :|9442373|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010702@unknown@formal@none@1@S@Control of NF-kappa B activity by the I kappa B beta inhibitor.@(((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 62)\n  (:start . 53) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1149.1) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010703@unknown@formal@none@1@S@The transcription factor NF-kappa B is maintained in an inactive cytoplasmic state by I kappa B inhibitors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1149.2) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010704@unknown@formal@none@1@S@In mammalian cells, I kappa B alpha and I kappa B beta proteins have been purified and shown to be the inhibitors of NF-kappa B through their association with the p65 or c-Rel subunits.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 47) (:start . 42)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 54) (:start . 50)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 63)\n  (:start . 55) (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 73) (:start . 69)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 82)\n  (:start . 74) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 92) (:start . 87)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 113)\n  (:start . 103) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 125)\n  (:start . 117) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 127) (:start . 126)\n  (:id . 67))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 135)\n  (:start . 128) (:id . 68))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 141)\n  (:start . 136) (:id . 69))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 153)\n  (:start . 142) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 166) (:start . 163)\n  (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 169) (:start . 167)\n  (:id . 74))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 175)\n  (:start . 170) (:id . 75))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 184)\n  (:start . 176) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1149.3) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010705@unknown@formal@none@1@S@In addition, we have isolated a third NF-kappa B inhibitor, I kappa B epsilon (1).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 67) (:start . 62)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 77)\n  (:start . 70) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1149.4) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010706@unknown@formal@none@1@S@Upon treatment with a large variety of inducers, I kappa B alpha, I kappa B beta are proteolytically degraded, resulting in NF-kappa B translocation into the nucleus.@(((:tag . "IN") (:stem . "upon") (:form . "Upon") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 80) (:start . 76)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 60))\n ((:tag . "RB") (:stem . "proteolytically") (:form . "proteolytically")\n  (:end . 100) (:start . 85) (:id . 61))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 120)\n  (:start . 111) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 132)\n  (:start . 124) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 148) (:start . 135) (:id . 68))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 165)\n  (:start . 158) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1149.5) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010707@unknown@formal@none@1@S@Here we show that in E29.1 T cell hybridoma I kappa B alpha and I kappa B beta are equally associated with p65 and that I kappa B beta is degraded in response to TNF alpha in contrast to what has been originally published.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "e29.1") (:form . "E29.1") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hybridoma") (:form . "hybridoma") (:end . 43)\n  (:start . 34) (:id . 50))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 59) (:start . 54)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 73) (:start . 72)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 78) (:start . 74)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 60))\n ((:tag . "RB") (:stem . "equally") (:form . "equally") (:end . 90)\n  (:start . 83) (:id . 61))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 101)\n  (:start . 91) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 66))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 121) (:start . 120)\n  (:id . 67))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 127)\n  (:start . 122) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 129) (:start . 128)\n  (:id . 69))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 134) (:start . 130)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 146)\n  (:start . 138) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 73))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 158)\n  (:start . 150) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 165) (:start . 162)\n  (:id . 76))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 171)\n  (:start . 166) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 78))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 183)\n  (:start . 175) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 80))\n ((:tag . "WP") (:stem . "what") (:form . "what") (:end . 191) (:start . 187)\n  (:id . 81))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 195) (:start . 192)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 200) (:start . 196)\n  (:id . 83))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 211)\n  (:start . 201) (:id . 84))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 221)\n  (:start . 212) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1149.6) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010708@unknown@formal@none@1@S@Our data also suggest that, unlike I kappa B alpha, I kappa B beta is constitutively phosphorylated and resynthesized as a hypophosphorylated form.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 53) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 59) (:start . 54)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 61) (:start . 60)\n  (:id . 56))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 66) (:start . 62)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 58))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 84) (:start . 70) (:id . 59))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 99) (:start . 85) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "resynthesize") (:form . "resynthesized")\n  (:end . 117) (:start . 104) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "hypophosphorylate") (:form . "hypophosphorylated")\n  (:end . 141) (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1149.7.1) (:span 14 21)))\n (:hscopes ((:id . :x1149.7.1) (:span 14 146)))\n (:identifiers (:sid . :s1149.7) (:did . :|9442374|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010710@unknown@formal@none@1@S@NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B/Rel") (:form . "B/Rel") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1150.1) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010711@unknown@formal@none@1@S@A kappa B-site was identified in the promoter of the intercellular adhesion molecule-1 (ICAM-1) gene, which is involved in regulation of ICAM-1 expression by tumor necrosis factor alpha (TNF-alpha) and glucocorticoids.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B-site") (:form . "B-site") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 143)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 154)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 163)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 172)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 179)\n  (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 196)\n  (:start . 187) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "glucocorticoid") (:form . "glucocorticoids")\n  (:end . 217) (:start . 202) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1150.2) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010712@unknown@formal@none@1@S@We now report on the transcription factors which bind and transactivate this enhancer sequence.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 13)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 34) (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1150.3) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010713@unknown@formal@none@1@S@In vitro, the ICAM-1 kappa B site appeared to bind RelA and c-Rel homodimers as well as heterodimers with NF-kappa B1, but weakly NF-kappa B1 homodimers.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 20)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 42)\n  (:start . 34) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 65) (:start . 60)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 76)\n  (:start . 66) (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 84) (:start . 80)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "heterodimer") (:form . "heterodimers") (:end . 100)\n  (:start . 88) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 129)\n  (:start . 123) (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 138)\n  (:start . 130) (:id . 67))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 152)\n  (:start . 142) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1150.4.1) (:span 34 42)))\n (:hscopes ((:id . :x1150.4.1) (:span 10 152)))\n (:identifiers (:sid . :s1150.4) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010714@unknown@formal@none@1@S@In addition, both RelA and c-Rel, but not NF-kappa B1, were shown to transactivate an ICAM-1 kappa B-reporter construct.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 65) (:start . 60)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 57))\n ((:tag . "VB") (:stem . "transactivate") (:form . "transactivate")\n  (:end . 82) (:start . 69) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 85) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 92)\n  (:start . 86) (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 98) (:start . 93)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "B-reporter") (:form . "B-reporter") (:end . 109)\n  (:start . 99) (:id . 62))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 119)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1150.5.1) (:span 38 41)))\n (:nscopes ((:id . :x1150.5.1) (:span 38 53)))\n (:identifiers (:sid . :s1150.5) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010715@unknown@formal@none@1@S@In monocytic THP-1 cells TNF-alpha induced two nuclear complexes which in vitro bound to the ICAM-1 kappa B site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1150.6) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010716@unknown@formal@none@1@S@Using antibodies in an electrophoretic mobility supershift assay, one of these complexes was shown to contain NF-kappa B1 and RelA, and to bind with higher affinity to the consensus kappa B site in the HIV long terminal repeat.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 64) (:start . 59)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "NNP") (:stem . "B1") (:form . "B1") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 164)\n  (:start . 156) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 181)\n  (:start . 172) (:id . 72))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 187)\n  (:start . 182) (:id . 73))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 189) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 205) (:start . 202)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 210) (:start . 206)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 219)\n  (:start . 211) (:id . 80))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 226)\n  (:start . 220) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1150.7) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010717@unknown@formal@none@1@S@The second complex contained RelA, and exhibited higher affinity towards the ICAM-1 kappa B than to the HIV kappa B site.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1150.8) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010718@unknown@formal@none@1@S@The glucocorticoid receptor was shown to repress activity of both the RelA homodimer and the NF-kappa B1/RelA heterodimer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NNP") (:stem . "B1/RelA") (:form . "B1/RelA") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 121)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1150.9) (:did . :|9442377|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010720@unknown@formal@none@1@S@LPS tolerance in monocytes/macrophages: three 3' cytosins are required in the DNA binding motif for detection of upregulated NF-kappa B p50 homodimers.@(((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 38) (:start . 17) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cytosin") (:form . "cytosins") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 150)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1151.1) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010721@unknown@formal@none@1@S@When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 58) (:start . 40) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "RB") (:stem . "repeatedly") (:form . "repeatedly") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "RB") (:stem . "initially") (:form . "initially") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 162) (:start . 159)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 178)\n  (:start . 173) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 182) (:start . 179)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 191)\n  (:start . 183) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 76))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 198) (:start . 195)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1151.2) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010722@unknown@formal@none@1@S@Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus.@(((:tag . "JJ") (:stem . "tolerant") (:form . "Tolerant") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VB") (:stem . "mobilize") (:form . "mobilize") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1151.3) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010723@unknown@formal@none@1@S@Analysis of the binding proteins employing the -605 motif of the human TNF promoter (GGGGCTGTCCC) revealed that in tolerant cells of the human monocytic cell line Mono Mac 6 there is a predominance of p50p50 of NF-kappa B.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBG") (:stem . "employ") (:form . "employing") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "CD") (:stem . "-605") (:form . "-605") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GGGGCTGTCCC") (:form . "GGGGCTGTCCC") (:end . 96)\n  (:start . 85) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 167) (:start . 163)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 179)\n  (:start . 174) (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 184) (:start . 183)\n  (:id . 75))\n ((:tag . "NN") (:stem . "predominance") (:form . "predominance") (:end . 197)\n  (:start . 185) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p50p50") (:form . "p50p50") (:end . 207)\n  (:start . 201) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 219)\n  (:start . 211) (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 221) (:start . 220)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1151.4) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010724@unknown@formal@none@1@S@We now show that a mutant motif that exchanges the terminal 3' C for a G fails to bind the p50 homodimer that is upregulated in LPS toler ant human Mono Mac 6 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "exchange") (:form . "exchanges") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 72) (:start . 71)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 78) (:start . 73)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 60))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 86) (:start . 82)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 94) (:start . 91)\n  (:id . 63))\n ((:tag . "NN") (:stem . "homodimer") (:form . "homodimer") (:end . 104)\n  (:start . 95) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 124)\n  (:start . 113) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 131) (:start . 128)\n  (:id . 69))\n ((:tag . "NN") (:stem . "toler") (:form . "toler") (:end . 137)\n  (:start . 132) (:id . 70))\n ((:tag . "JJ") (:stem . "ant") (:form . "ant") (:end . 141) (:start . 138)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 147)\n  (:start . 142) (:id . 72))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 152) (:start . 148)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Mac") (:form . "Mac") (:end . 156) (:start . 153)\n  (:id . 74))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 158) (:start . 157)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x1151.5.1) (:span 73 78)))\n (:nscopes ((:id . :x1151.5.1) (:span 73 164)))\n (:identifiers (:sid . :s1151.5) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010725@unknown@formal@none@1@S@The same is true for nuclear extracts taken from the murine P388D1 macrophage cell line when tested with the -516 motif of the murine TNF promoter (GGGGGCTTTCCC).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "p388d1") (:form . "P388D1") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 99) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "CD") (:stem . "-516") (:form . "-516") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 133)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "GGGGGCTTTCCC") (:form . "GGGGGCTTTCCC")\n  (:end . 160) (:start . 148) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1151.6) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010726@unknown@formal@none@1@S@Here the wild type motif gives efficient binding of p50p50 that again is upregulated in tolerant cells whereas a mutant with a 3' G shows hardly any binding of p50p50.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "give") (:form . "gives") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p50p50") (:form . "p50p50") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "RB") (:stem . "hardly") (:form . "hardly") (:end . 144)\n  (:start . 138) (:id . 68))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 148) (:start . 145)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "NN") (:stem . "p50p50") (:form . "p50p50") (:end . 166)\n  (:start . 160) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1151.7) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010727@unknown@formal@none@1@S@Conversely, the murine kappa light chain enhancer motif (GGGGACTTTCCG) does not efficiently bind the nuclear p50p50 from tolerant murine P388 macrophages.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GGGGACTTTCCG") (:form . "GGGGACTTTCCG") (:end . 69)\n  (:start . 57) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "p50p50") (:form . "p50p50") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "p388") (:form . "P388") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 153)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1151.8.1) (:span 76 79)))\n (:nscopes ((:id . :x1151.8.1) (:span 76 153)))\n (:identifiers (:sid . :s1151.8) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010728@unknown@formal@none@1@S@Binding is, however, readily detected when the 3' G is replaced by a C.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "replace") (:form . "replaced") (:end . 63)\n  (:start . 55) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 70) (:start . 69)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1151.9) (:did . :|9442380|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010730@unknown@formal@none@1@S@Temporal control of IgH gene expression in developing B cells by the 3' locus control region.@(((:tag . "JJ") (:stem . "temporal") (:form . "Temporal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1152.1) (:did . :|9442395|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010731@unknown@formal@none@1@S@The suggested roles of the downstream 3' regions acting as a Locus Control Region (LCR), have allowed comparisons to be made between the regulation of the IgH locus with other model systems whose gene expression is governed by LCR activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 55) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Locus") (:form . "Locus") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Control") (:form . "Control") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NNP") (:stem . "Region") (:form . "Region") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LCR") (:form . "LCR") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 93) (:start . 89)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "allow") (:form . "allowed") (:end . 101)\n  (:start . 94) (:id . 62))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 113)\n  (:start . 102) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 132)\n  (:start . 125) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 147)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 158) (:start . 155)\n  (:id . 72))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 164)\n  (:start . 159) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 175)\n  (:start . 170) (:id . 75))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 181)\n  (:start . 176) (:id . 76))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 189)\n  (:start . 182) (:id . 77))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 195)\n  (:start . 190) (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 200) (:start . 196)\n  (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 211)\n  (:start . 201) (:id . 80))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 214) (:start . 212)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "govern") (:form . "governed") (:end . 223)\n  (:start . 215) (:id . 82))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 226) (:start . 224)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "LCR") (:form . "LCR") (:end . 230) (:start . 227)\n  (:id . 84))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 239)\n  (:start . 231) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x1152.2.1) (:span 4 13)))\n (:hscopes ((:id . :x1152.2.1) (:span 4 87)))\n (:identifiers (:sid . :s1152.2) (:did . :|9442395|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010732@unknown@formal@none@1@S@Here we summarize the importance of the IgH 3'LCR and its putative functional role in IgH gene expression and compare it with the 5'LCR regulatory region of the human beta-globin locus.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "summarize") (:form . "summarize") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "3'LCR") (:form . "3'LCR") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IgH") (:form . "IgH") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "5'LCR") (:form . "5'LCR") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 146)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 153)\n  (:start . 147) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1152.3.1) (:span 58 66)))\n (:hscopes ((:id . :x1152.3.1) (:span 58 105)))\n (:identifiers (:sid . :s1152.3) (:did . :|9442395|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010733@unknown@formal@none@1@S@Expression of transcription factor genes after influenza A virus infection.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 34)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "influenza") (:form . "influenza") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1153.1) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010734@unknown@formal@none@1@S@Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis.@(((:tag . "NN") (:stem . "infection") (:form . "Infection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "influenza") (:form . "influenza") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "broad") (:form . "broad") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 92) (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "attract") (:form . "attracting") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 145)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 152)\n  (:start . 146) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 65))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 189)\n  (:start . 180) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1153.2) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010735@unknown@formal@none@1@S@The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorly understood.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 80) (:start . 63) (:id . 51))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 90)\n  (:start . 81) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 129)\n  (:start . 123) (:id . 58))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 140)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1153.3) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010736@unknown@formal@none@1@S@Activation of NF-kappa B seems to play an important role in the regulation of many proinflammatory cytokine genes, but cannot be the only mechanism, since several cytokine genes lack respective binding sites in their promoter regions.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 98) (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cannot") (:form . "cannot") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 147)\n  (:start . 138) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 162)\n  (:start . 155) (:id . 69))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 182) (:start . 178)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 193)\n  (:start . 183) (:id . 73))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 201)\n  (:start . 194) (:id . 74))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 207)\n  (:start . 202) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 76))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 216)\n  (:start . 211) (:id . 77))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 225)\n  (:start . 217) (:id . 78))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 233)\n  (:start . 226) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1153.4.2) (:span 119 128))\n  ((:id . :x1153.4.3) (:span 25 30)))\n (:ncues ((:id . :x1153.4.1) (:span 178 182)))\n (:hscopes ((:id . :x1153.4.2) (:span 119 147))\n  ((:id . :x1153.4.3) (:span 0 113)))\n (:nscopes ((:id . :x1153.4.1) (:span 178 233)))\n (:identifiers (:sid . :s1153.4) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010737@unknown@formal@none@1@S@Therefore, we additionally investigated other transcription factors of possible importance such as CREB, CTF, OTF-1, and OTF-2.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "additionally") (:form . "additionally") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 79)\n  (:start . 71) (:id . 51))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 90)\n  (:start . 80) (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CTF") (:form . "CTF") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "OTF-1") (:form . "OTF-1") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1153.5.1) (:span 71 79)))\n (:hscopes ((:id . :x1153.5.1) (:span 71 90)))\n (:identifiers (:sid . :s1153.5) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010738@unknown@formal@none@1@S@To explore long-term regulatory mechanisms, we investigated the induction of transcription factors on the gene expression level which may be important to substitute for metabolized transcription factor proteins after their activation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 90) (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "metabolize") (:form . "metabolized") (:end . 180)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 194) (:start . 181) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 201)\n  (:start . 195) (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 210)\n  (:start . 202) (:id . 70))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 216)\n  (:start . 211) (:id . 71))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 222)\n  (:start . 217) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 233)\n  (:start . 223) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1153.6.1) (:span 134 137)))\n (:hscopes ((:id . :x1153.6.1) (:span 134 233)))\n (:identifiers (:sid . :s1153.6) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010740@unknown@formal@none@1@S@In infected monocytes, which die by apoptosis, the expression of CREB, CTF, and OTF-2 was rather suppressed 8 hours after infection.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "die") (:form . "die") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CTF") (:form . "CTF") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "otf-2") (:form . "OTF-2") (:end . 85) (:start . 80)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 60))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 96)\n  (:start . 90) (:id . 61))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 107)\n  (:start . 97) (:id . 62))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 115)\n  (:start . 110) (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 121)\n  (:start . 116) (:id . 65))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 131)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1153.8) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010741@unknown@formal@none@1@S@In conclusion, the long-term regulation of transcription factor gene expression in non-proliferating cells seems to be of minor importance after influenza infection since in apoptosisprone cells an immediate availability of transcription factor proteins is required.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "long-term") (:form . "long-term") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "non-proliferating") (:form . "non-proliferating")\n  (:end . 100) (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 138)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "influenza") (:form . "influenza") (:end . 154)\n  (:start . 145) (:id . 63))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 164)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 170)\n  (:start . 165) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "apoptosisprone") (:form . "apoptosisprone")\n  (:end . 188) (:start . 174) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 194)\n  (:start . 189) (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 197) (:start . 195)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "immediate") (:form . "immediate") (:end . 207)\n  (:start . 198) (:id . 70))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 220)\n  (:start . 208) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 237) (:start . 224) (:id . 73))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 244)\n  (:start . 238) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 253)\n  (:start . 245) (:id . 75))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 256) (:start . 254)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 265)\n  (:start . 257) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1153.9.1) (:span 107 112)))\n (:hscopes ((:id . :x1153.9.1) (:span 15 164)))\n (:identifiers (:sid . :s1153.9) (:did . :|9442400|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010742@unknown@formal@none@1@S@[Molecular-biologic aspects of interaction between nervous and immune systems]@(((:tag . "(") (:stem . "[") (:form . "[") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "molecular-biologic") (:form . "Molecular-biologic")\n  (:end . 19) (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 78) (:start . 77)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1154.1) (:did . :|9446322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010743@unknown@formal@none@1@S@The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "neuro-immuno") (:form . "neuro-immuno") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "trans-factor") (:form . "trans-factors")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "stimulate") (:form . "stimulating") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 113) (:start . 100) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1154.2) (:did . :|9446322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010744@unknown@formal@none@1@S@The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "physico-chemical") (:form . "physico-chemical")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BP-") (:form . "BP-") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "kd") (:form . "kDs") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 121)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 134)\n  (:start . 127) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 150)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "immunize") (:form . "immunized") (:end . 163)\n  (:start . 154) (:id . 71))\n ((:tag . "NNS") (:stem . "rat") (:form . "rats") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 173) (:start . 169)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 181)\n  (:start . 174) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1154.3) (:did . :|9446322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010745@unknown@formal@none@1@S@The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IL-2mRNA") (:form . "IL-2mRNA") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "splenic") (:form . "splenic") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 143) (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 161)\n  (:start . 155) (:id . 67))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 172)\n  (:start . 162) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 183)\n  (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1154.4) (:did . :|9446322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010746@unknown@formal@none@1@S@The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BP") (:form . "BP") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-2mRNA") (:form . "IL-2mRNA") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "stressful") (:form . "stressful") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CsA") (:form . "CsA") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 143)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1154.5) (:did . :|9446322|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010747@unknown@formal@none@1@S@Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB.@(((:tag . "NNP") (:stem . "Induction") (:form . "Induction") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-12") (:form . "interleukin-12")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 99) (:start . 86) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1155.1) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010748@unknown@formal@none@1@S@Interleukin-12 is produced in response to infection with bacteria or parasites or to bacterial constituents such as LPS in monocytes/macrophages and dendritic cells, and also generated by the interaction between activated T cells and antigen-presenting cells via CD40-CD40 ligand (CD40L).@(((:tag . "NN") (:stem . "interleukin-12") (:form . "Interleukin-12")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "parasite") (:form . "parasites") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "constituent") (:form . "constituents") (:end . 107)\n  (:start . 95) (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 144) (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 158)\n  (:start . 149) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 184)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 187) (:start . 185)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 203)\n  (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 211)\n  (:start . 204) (:id . 72))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 221)\n  (:start . 212) (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 223) (:start . 222)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 229)\n  (:start . 224) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 233) (:start . 230)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "antigen-presenting") (:form . "antigen-presenting")\n  (:end . 252) (:start . 234) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 258)\n  (:start . 253) (:id . 78))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 262) (:start . 259)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "CD40-CD40") (:form . "CD40-CD40") (:end . 272)\n  (:start . 263) (:id . 80))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 279)\n  (:start . 273) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 281) (:start . 280)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 286)\n  (:start . 281) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 287) (:start . 286)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1155.2) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010750@unknown@formal@none@1@S@In the present study, we have characterized the transcriptional induction of p40 by CD40 ligation in a human B lymphoblastoid cell line, Daudi, and a human acute monocytic leukemia cell line, THP-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 43) (:start . 30) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 63) (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 125) (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 155)\n  (:start . 150) (:id . 70))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 161)\n  (:start . 156) (:id . 71))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 171)\n  (:start . 162) (:id . 72))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 180)\n  (:start . 172) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 190) (:start . 186)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 197)\n  (:start . 192) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1155.4) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010751@unknown@formal@none@1@S@These cells, stimulated by an agonistic monoclonal antibody against CD40 or by transfection with a CD40L expression vector, secreted p40 and showed enhanced p40 mRNA expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "agonistic") (:form . "agonistic") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 91)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 104)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 165) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 176)\n  (:start . 166) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1155.5) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010752@unknown@formal@none@1@S@Sequence analysis of the p40 promoter region identified two potential nuclear factor (NF)-kappaB binding sites conserved between mouse and human.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "human") (:form . "human") (:end . 144)\n  (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1155.6.1) (:span 60 69)))\n (:hscopes ((:id . :x1155.6.1) (:span 60 144)))\n (:identifiers (:sid . :s1155.6) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010753@unknown@formal@none@1@S@Electrophoretic mobility shift assay revealed that the potential NF-kappaB binding sequence which is located around 120 bp upstream of the transcription initiation site in murine and human p40 genes formed an NF-kappaB complex with nuclear extract from Daudi cells stimulated by CD40 ligation.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 119) (:start . 116)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 131)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 152) (:start . 139) (:id . 62))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 163)\n  (:start . 153) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 168) (:start . 164)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 188)\n  (:start . 183) (:id . 68))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 192) (:start . 189)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 198)\n  (:start . 193) (:id . 70))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 205)\n  (:start . 199) (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 218)\n  (:start . 209) (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 226)\n  (:start . 219) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 231) (:start . 227)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 239)\n  (:start . 232) (:id . 76))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 247)\n  (:start . 240) (:id . 77))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 252) (:start . 248)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 258)\n  (:start . 253) (:id . 79))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 264)\n  (:start . 259) (:id . 80))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 275)\n  (:start . 265) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 278) (:start . 276)\n  (:id . 82))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 283) (:start . 279)\n  (:id . 83))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 292)\n  (:start . 284) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x1155.7.1) (:span 55 64)))\n (:hscopes ((:id . :x1155.7.1) (:span 55 198)))\n (:identifiers (:sid . :s1155.7) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010754@unknown@formal@none@1@S@Moreover, transfection of Daudi cells with the polymerized NF-kappaB binding sequence ligated to a thymidine kinase/chloramphenicol acetyltransferase (CAT) reporter plasmid greatly induced CAT activity, but transfection with the polymerized mutated NF-kappaB binding sequence did not.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "polymerized") (:form . "polymerized") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "VBN") (:stem . "ligate") (:form . "ligated") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "thymidine") (:form . "thymidine") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "kinase/chloramphenicol")\n  (:form . "kinase/chloramphenicol") (:end . 131) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 149) (:start . 132) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 154) (:start . 151)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 62))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 172)\n  (:start . 165) (:id . 64))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 180)\n  (:start . 173) (:id . 65))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 188)\n  (:start . 181) (:id . 66))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 192) (:start . 189)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 201)\n  (:start . 193) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 206) (:start . 203)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 219)\n  (:start . 207) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 224) (:start . 220)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "polymerized") (:form . "polymerized") (:end . 240)\n  (:start . 229) (:id . 74))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 248)\n  (:start . 241) (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 258)\n  (:start . 249) (:id . 76))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 266)\n  (:start . 259) (:id . 77))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 275)\n  (:start . 267) (:id . 78))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 279) (:start . 276)\n  (:id . 79))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 283) (:start . 280)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 284) (:start . 283)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1155.8.1) (:span 280 283)))\n (:nscopes ((:id . :x1155.8.1) (:span 280 283)))\n (:identifiers (:sid . :s1155.8) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010755@unknown@formal@none@1@S@These results suggest that the NF-kappaB binding site located around 120 bp upstream of the transcription initiation site in murine and human p40 promoter regions could be important for the p40 induction by CD40 ligation via activation of NF-kappaB.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "CD") (:stem . "120") (:form . "120") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 168)\n  (:start . 163) (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 203)\n  (:start . 194) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 211) (:start . 207)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 220)\n  (:start . 212) (:id . 76))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 224) (:start . 221)\n  (:id . 77))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 235)\n  (:start . 225) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 238) (:start . 236)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 248)\n  (:start . 239) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1155.9.1) (:span 163 168))\n  ((:id . :x1155.9.2) (:span 14 21)))\n (:hscopes ((:id . :x1155.9.1) (:span 163 248))\n  ((:id . :x1155.9.2) (:span 14 248)))\n (:identifiers (:sid . :s1155.9) (:did . :|9464836|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010756@unknown@formal@none@1@S@Oxidants, transcription factors, and intestinal inflammation.@(((:tag . "NNP") (:stem . "Oxidant") (:form . "Oxidants") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1156.1) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010757@unknown@formal@none@1@S@It is now well appreciated that chronic gut inflammation is characterized by enhanced production of reactive metabolites of oxygen and nitrogen.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "appreciate") (:form . "appreciated") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "gut") (:form . "gut") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 56)\n  (:start . 44) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 73) (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 120)\n  (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "nitrogen") (:form . "nitrogen") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1156.2) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010758@unknown@formal@none@1@S@Some of these oxidants are known to modulate the expression of a variety of genes that are involved in the immune and inflammatory responses.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "oxidant") (:form . "oxidants") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 130)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1156.3) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010760@unknown@formal@none@1@S@Oxidants are also known to activate another transcription factor, activator protein-1.@(((:tag . "NNS") (:stem . "oxidant") (:form . "Oxidants") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1156.5) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010761@unknown@formal@none@1@S@This transcription factor is composed of products from the fos and jun proto-oncogene family and is believed to be important in regulating cell growth and proliferation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fos") (:form . "fos") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "jun") (:form . "jun") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proto-oncogene") (:form . "proto-oncogene")\n  (:end . 85) (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 138)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 143) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 168) (:start . 155) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1156.6.1) (:span 100 108)))\n (:hscopes ((:id . :x1156.6.1) (:span 97 168)))\n (:identifiers (:sid . :s1156.6) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010762@unknown@formal@none@1@S@Finally, oxidants are believed to promote intestinal epithelial cell apoptosis, and the B-cell lymphoma/leukemia-2 gene product is believed to inhibit this phenomenon in an antioxidant-dependent manner.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "oxidant") (:form . "oxidants") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "lymphoma/leukemia-2")\n  (:form . "lymphoma/leukemia-2") (:end . 114) (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 127)\n  (:start . 120) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 139)\n  (:start . 131) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 150)\n  (:start . 143) (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 166)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "antioxidant-dependent")\n  (:form . "antioxidant-dependent") (:end . 194) (:start . 173) (:id . 68))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 201)\n  (:start . 195) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1156.7.1) (:span 131 139))\n  ((:id . :x1156.7.2) (:span 22 30)))\n (:hscopes ((:id . :x1156.7.1) (:span 84 201))\n  ((:id . :x1156.7.2) (:span 9 78)))\n (:identifiers (:sid . :s1156.7) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010763@unknown@formal@none@1@S@Taken together, these observations suggest that nontoxic concentrations of reactive metabolites of oxygen and nitrogen play an important role in regulating the expression of genes involved in the inflammatory response and in modulating apoptosis.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nontoxic") (:form . "nontoxic") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "metabolite") (:form . "metabolites") (:end . 95)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 105)\n  (:start . 99) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nitrogen") (:form . "nitrogen") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 136)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 179)\n  (:start . 174) (:id . 67))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 188)\n  (:start . 180) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 208)\n  (:start . 196) (:id . 71))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 217)\n  (:start . 209) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 235)\n  (:start . 225) (:id . 75))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 245)\n  (:start . 236) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1156.8.1) (:span 35 42)))\n (:hscopes ((:id . :x1156.8.1) (:span 35 245)))\n (:identifiers (:sid . :s1156.8) (:did . :|9479628|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010764@unknown@formal@none@1@S@Cytokine rescue from glucocorticoid induced apoptosis in T cells is mediated through inhibition of IkappaBalpha.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokine") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 53)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 111) (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1157.1) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010765@unknown@formal@none@1@S@We previously reported that dexamethasone (DEX), a synthetic glucocorticoid, causes apoptosis in mature Th cell lines, and that this induction of cell death is prevented by specific cytokines, namely, by IL-2 in Th1 cells and by IL-4 in Th2 cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "DEX") (:form . "DEX") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 75) (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 169)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 181)\n  (:start . 173) (:id . 73))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 75))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 199)\n  (:start . 193) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 78))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 208) (:start . 204)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 80))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 215) (:start . 212)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 221)\n  (:start . 216) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 83))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 228) (:start . 226)\n  (:id . 84))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 233) (:start . 229)\n  (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 86))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 240) (:start . 237)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 246)\n  (:start . 241) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s1157.2) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010766@unknown@formal@none@1@S@We now show that this differential rescue by specific cytokines in Th cells correlates with the level of IkappaBalpha that is regulated by DEX and cytokines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "th") (:form . "Th") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 117) (:start . 105) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dex") (:form . "DEX") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 156)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1157.3) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010767@unknown@formal@none@1@S@In both cell types the cellular levels of IkappaBalpha mRNA and protein were evaluated by DEX treatment.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dex") (:form . "DEX") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1157.4) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010768@unknown@formal@none@1@S@Interestingly, the DEX-mediated IkappaBalpha induction was completely inhibited by IL-2, but not IL-4, in Th1 cells, while the reverse profile was seen in Th2 cells.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dex-mediated") (:form . "DEX-mediated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 69)\n  (:start . 59) (:id . 49))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 79)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 87) (:start . 83)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "reverse") (:form . "reverse") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x1157.5.1) (:span 93 96)))\n (:nscopes ((:id . :x1157.5.1) (:span 93 101)))\n (:identifiers (:sid . :s1157.5) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010770@unknown@formal@none@1@S@Our results imply that T cells need to maintain a certain level of NF-kappaB transcriptional activity in order to survive; up- or down-regulation of nuclear NF kappaB through modulation of IkappaBalpha expression by cytokines or DEX may lead to cell survival or cell death, respectively.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "need") (:form . "need") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "TO") (:stem . 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(:end . 287) (:start . 286)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x1157.7.1) (:span 233 236))\n  ((:id . :x1157.7.2) (:span 12 17)))\n (:hscopes ((:id . :x1157.7.1) (:span 233 286))\n  ((:id . :x1157.7.2) (:span 12 121)))\n (:identifiers (:sid . :s1157.7) (:did . :|9488049|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010771@unknown@formal@none@1@S@Xenogeneic human serum promotes leukocyte adhesion to porcine endothelium under flow conditions, possibly through the activation of the transcription factor NF-kappa B.@(((:tag . "JJ") (:stem . "xenogeneic") (:form . "Xenogeneic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "porcine") (:form . "porcine") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 79) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 95)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 156)\n  (:start . 150) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 165)\n  (:start . 157) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 167) (:start . 166)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1158.1.1) (:span 97 105)))\n (:hscopes ((:id . :x1158.1.1) (:span 97 167)))\n (:identifiers (:sid . :s1158.1) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010772@unknown@formal@none@1@S@Endothelial cell activation and leukocyte infiltration are a consistent feature of discordant xenograft rejection.@(((:tag . "JJ") (:stem . "endothelial") (:form . "Endothelial") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 54)\n  (:start . 42) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "discordant") (:form . "discordant") (:end . 93)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "xenograft") (:form . "xenograft") (:end . 103)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "rejection") (:form . "rejection") (:end . 113)\n  (:start . 104) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1158.2) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010773@unknown@formal@none@1@S@Here we evaluated whether xenogeneic serum, as a source of xenoreactive natural antibodies and complement, induced endothelial cell activation with consequent leukocyte adhesion under flow conditions.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "xenogeneic") (:form . "xenogeneic") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "xenoreactive") (:form . "xenoreactive") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 105)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 126)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "consequent") (:form . "consequent") (:end . 158)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 168)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 183)\n  (:start . 178) (:id . 67))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 188) (:start . 184)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 199)\n  (:start . 189) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1158.3.1) (:span 18 25)))\n (:hscopes ((:id . :x1158.3.1) (:span 18 199)))\n (:identifiers (:sid . :s1158.3) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010774@unknown@formal@none@1@S@Porcine aortic endothelial cells (PAEC) were incubated for 1 hr 30 min or 5 hr with 10% homologous porcine serum (control) or 10% xenogeneic human serum and then perfused with total human leukocytes in a parallel plate flow chamber under laminar flow (1.5 dynes/cm2).@(((:tag . "JJ") (:stem . "porcine") (:form . "Porcine") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "aortic") (:form . "aortic") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PAEC") (:form . "PAEC") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . 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5010775@unknown@formal@none@1@S@Adherent cells were counted by digital image analysis.@(((:tag . "JJ") (:stem . "adherent") (:form . "Adherent") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "count") (:form . "counted") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "digital") (:form . "digital") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "image") (:form . "image") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1158.5) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010776@unknown@formal@none@1@S@Xenogeneic human serum significantly (P < 0.01) increased the number of adherent leukocytes as compared with porcine serum.@(((:tag . "JJ") (:stem . "xenogeneic") (:form . "Xenogeneic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 36) (:start . 23) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adherent") (:form . "adherent") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "porcine") (:form . "porcine") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1158.6) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010777@unknown@formal@none@1@S@A similar adhesive response was elicited by TNF alpha (100 U/ml), one of the most potent inducers of endothelial cell adhesive properties, here used as positive control.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "adhesive") (:form . "adhesive") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "U/ml") (:form . "U/ml") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 81) (:start . 77)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 88)\n  (:start . 82) (:id . 60))\n ((:tag . "NNS") (:stem . "inducer") (:form . "inducers") (:end . 97)\n  (:start . 89) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 112)\n  (:start . 101) (:id . 63))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "adhesive") (:form . "adhesive") (:end . 126)\n  (:start . 118) (:id . 65))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 137)\n  (:start . 127) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 148) (:start . 144)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 160)\n  (:start . 152) (:id . 71))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 168)\n  (:start . 161) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1158.7) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010778@unknown@formal@none@1@S@In order to elucidate possible mechanisms underlying endothelial cell activation by xenogeneic serum, we focussed on transcription factor NF-kappa B, a central regulator for the induction of different genes, including adhesive molecules and chemoattractants.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "xenogeneic") (:form . "xenogeneic") (:end . 94)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "focusse") (:form . "focussed") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 169)\n  (:start . 160) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 187)\n  (:start . 178) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 200)\n  (:start . 191) (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 206)\n  (:start . 201) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 217)\n  (:start . 208) (:id . 74))\n ((:tag . "JJ") (:stem . "adhesive") (:form . "adhesive") (:end . 226)\n  (:start . 218) (:id . 75))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 236)\n  (:start . 227) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 240) (:start . 237)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "chemoattractant") (:form . "chemoattractants")\n  (:end . 257) (:start . 241) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1158.8.1) (:span 22 30)))\n (:hscopes ((:id . :x1158.8.1) (:span 22 100)))\n (:identifiers (:sid . :s1158.8) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010780@unknown@formal@none@1@S@At variance, in PAEC incubated with the homologous serum, NF-kappa B was strictly localized in the cell cytoplasm.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "variance") (:form . "variance") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PAEC") (:form . "PAEC") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 113)\n  (:start . 104) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1158.10) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010781@unknown@formal@none@1@S@Treatment of PAEC exposed to xenogeneic serum with the NF-kappa B inhibitors pyrrolidinedithiocarbamate (PDTC, 25 microM) and tosyl-phechloromethylketone (TPCK, 25 microM) significantly (P < 0.01) reduced leukocyte adhesion in respect to PAEC treated with human serum alone.@(((:tag . "NNP") (:stem . "Treatment") (:form . "Treatment") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PAEC") (:form . "PAEC") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "xenogeneic") (:form . "xenogeneic") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "pyrrolidinedithiocarbamate")\n  (:form . "pyrrolidinedithiocarbamate") (:end . 103) (:start . 77)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PDTC") (:form . "PDTC") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "microm") (:form . "microM") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tosyl-phechloromethylketone")\n  (:form . "tosyl-phechloromethylketone") (:end . 153) (:start . 126)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TPCK") (:form . "TPCK") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 65))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 68))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 185) (:start . 172) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 188) (:start . 187)\n  (:id . 71))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 195) (:start . 191)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 204)\n  (:start . 197) (:id . 75))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 214)\n  (:start . 205) (:id . 76))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 223)\n  (:start . 215) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 78))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 234)\n  (:start . 227) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 237) (:start . 235)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "PAEC") (:form . "PAEC") (:end . 242) (:start . 238)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 250)\n  (:start . 243) (:id . 82))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 255) (:start . 251)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 261)\n  (:start . 256) (:id . 84))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 267)\n  (:start . 262) (:id . 85))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 273)\n  (:start . 268) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 274) (:start . 273)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1158.11) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010782@unknown@formal@none@1@S@Findings that xenogeneic serum promotes leukocyte-endothelium interaction possibly through NF-kappa B activation might be relevant for designing future therapeutic strategies aimed at prolonging xenograft survival.@(((:tag . "NNS") (:stem . "finding") (:form . "Findings") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "xenogeneic") (:form . "xenogeneic") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "leukocyte-endothelium")\n  (:form . "leukocyte-endothelium") (:end . 61) (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 73)\n  (:start . 62) (:id . 48))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 82)\n  (:start . 74) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 90)\n  (:start . 83) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 99)\n  (:start . 91) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 118)\n  (:start . 113) (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 130)\n  (:start . 122) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "design") (:form . "designing") (:end . 144)\n  (:start . 135) (:id . 58))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 151)\n  (:start . 145) (:id . 59))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 163)\n  (:start . 152) (:id . 60))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 174)\n  (:start . 164) (:id . 61))\n ((:tag . "VBN") (:stem . "aim") (:form . "aimed") (:end . 180) (:start . 175)\n  (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 183) (:start . 181)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "prolong") (:form . "prolonging") (:end . 194)\n  (:start . 184) (:id . 64))\n ((:tag . "NN") (:stem . "xenograft") (:form . "xenograft") (:end . 204)\n  (:start . 195) (:id . 65))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 213)\n  (:start . 205) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1158.12.1) (:span 113 118))\n  ((:id . :x1158.12.2) (:span 74 82)))\n (:hscopes ((:id . :x1158.12.1) (:span 113 213))\n  ((:id . :x1158.12.2) (:span 74 112)))\n (:identifiers (:sid . :s1158.12) (:did . :|9507734|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010783@unknown@formal@none@1@S@Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 43) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 98) (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1159.1) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010784@unknown@formal@none@1@S@The NF-kappaB family of transcription factors regulates the inducible expression of a variety of genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1159.2) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010785@unknown@formal@none@1@S@Recently, we showed that elevation of intracellular cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytes and endothelial cells without preventing nuclear translocation of NF-kappaB complexes.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 19) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "amp") (:form . "AMP") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 90) (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 104) (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 139)\n  (:start . 128) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 60))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 153)\n  (:start . 146) (:id . 61))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 164)\n  (:start . 154) (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 172)\n  (:start . 165) (:id . 63))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 186) (:start . 173) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 199)\n  (:start . 190) (:id . 66))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 209)\n  (:start . 200) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1159.3.1) (:span 146 153)))\n (:nscopes ((:id . :x1159.3.1) (:span 146 209)))\n (:identifiers (:sid . :s1159.3) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010786@unknown@formal@none@1@S@The present study examined the molecular mechanism of this inhibition.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1159.4) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010787@unknown@formal@none@1@S@We hypothesized that activation of the protein kinase A signaling pathway may inhibit NF-kappaB-mediated transcription by phosphorylating proteins, such as cAMP response element-binding protein (CREB), which compete for limiting amounts of the coactivator CBP.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "JJ") (:stem . "nf-kappab-mediated") (:form . "NF-kappaB-mediated")\n  (:end . 104) (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "phosphorylate") (:form . "phosphorylating")\n  (:end . 137) (:start . 122) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 146)\n  (:start . 138) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 155) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 160) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 169)\n  (:start . 161) (:id . 64))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 185) (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 193)\n  (:start . 186) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 199) (:start . 195)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 207)\n  (:start . 202) (:id . 71))\n ((:tag . "VBP") (:stem . "compete") (:form . "compete") (:end . 215)\n  (:start . 208) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 219) (:start . 216)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 228)\n  (:start . 220) (:id . 74))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 236)\n  (:start . 229) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 243) (:start . 240)\n  (:id . 77))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 255)\n  (:start . 244) (:id . 78))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 259) (:start . 256)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1159.5.1) (:span 74 77)) ((:id . :x1159.5.2) (:span 3 15)))\n (:hscopes ((:id . :x1159.5.1) (:span 74 259))\n  ((:id . :x1159.5.2) (:span 3 259)))\n (:identifiers (:sid . :s1159.5) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010788@unknown@formal@none@1@S@Here, we show that the amino-terminal region (amino acids 1-450) of CBP specifically interacts with the carboxyl-terminal region (amino acids 286-551) of NF-kappaB p65 (RelA) both in vitro and in vivo.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 37) (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1-450") (:form . "1-450") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 84)\n  (:start . 72) (:id . 57))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 121) (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "CD") (:stem . "286-551") (:form . "286-551") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 163)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 173) (:start . 169)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 179) (:start . 175)\n  (:id . 74))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 188)\n  (:start . 183) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 77))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 78))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 200) (:start . 196)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1159.6) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010790@unknown@formal@none@1@S@In contrast, overexpression of CREB inhibited GAL4-p65(286-551)-mediated transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "GAL4-p65(286-551)-mediated")\n  (:form . "GAL4-p65(286-551)-mediated") (:end . 72) (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 86) (:start . 73) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1159.8) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010791@unknown@formal@none@1@S@These results suggest that activation of the protein kinase A pathway inhibits NF-kappaB transcription by phosphorylating CREB, which competes with p65 for limiting amounts of CBP.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "phosphorylate") (:form . "phosphorylating")\n  (:end . 121) (:start . 106) (:id . 57))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "VBZ") (:stem . "compete") (:form . "competes") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 179) (:start . 176)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1159.9.1) (:span 14 21)))\n (:hscopes ((:id . :x1159.9.1) (:span 14 179)))\n (:identifiers (:sid . :s1159.9) (:did . :|9548485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010792@unknown@formal@none@1@S@Differential induction of DNA-binding activities following CD19 cross-linking in human B lineage cells.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 48)\n  (:start . 38) (:id . 46))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 58)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 63) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 77) (:start . 64) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 96)\n  (:start . 89) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1160.1) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010793@unknown@formal@none@1@S@The B cell-specific cell surface molecule CD19 is expressed at all stages of B cell development, including normal plasma cells, and mediates signal transduction via interaction with cytoplasmic effector proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 19) (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 160)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 176)\n  (:start . 165) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 193)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 202)\n  (:start . 194) (:id . 72))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 211)\n  (:start . 203) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1160.2) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010794@unknown@formal@none@1@S@Cross-linking CD19 on early human B lineage cells induces the formation of a CD19/Vav/phosphatidylinositol-3 kinase complex, tyrosine phosphorylation of CD19 and Vav, and activation of the Ras pathway.@(((:tag . "JJ") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD19/Vav/phosphatidylinositol-3")\n  (:form . "CD19/Vav/phosphatidylinositol-3") (:end . 108) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 123)\n  (:start . 116) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 149) (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CD19") (:form . "CD19") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 165) (:start . 162)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 181)\n  (:start . 171) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1160.3) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010795@unknown@formal@none@1@S@To further explore the ramifications of CD19 signaling, the current study examined whether phosphorylation of Elk-1, activation of activator protein-1 (AP-1), or activation of nuclear factor-kappaB (NF-kappaB) transcription factors occurred following CD19 cross-linking.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ramification") (:form . "ramifications")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 106) (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Elk-1") (:form . "Elk-1") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 172)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 197) (:start . 184) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 208)\n  (:start . 199) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 223) (:start . 210) (:id . 76))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 231)\n  (:start . 224) (:id . 77))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 240)\n  (:start . 232) (:id . 78))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 250)\n  (:start . 241) (:id . 79))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 255) (:start . 251)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 269) (:start . 256) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1160.4.1) (:span 83 90)))\n (:hscopes ((:id . :x1160.4.1) (:span 83 269)))\n (:identifiers (:sid . :s1160.4) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010796@unknown@formal@none@1@S@The cells used were the BLIN-1 pre-B cell line expressing low levels of cell surface mu heavy chain associated with surrogate light chain and the 1E8 immature B cell line expressing cell surface mu/kappa.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blin-1") (:form . "BLIN-1") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "mu") (:form . "mu") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "surrogate") (:form . "surrogate") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "JJ") (:stem . "light") (:form . "light") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "1e8") (:form . "1E8") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 158)\n  (:start . 150) (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 170) (:start . 166)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 181)\n  (:start . 171) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 186) (:start . 182)\n  (:id . 73))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 194)\n  (:start . 187) (:id . 74))\n ((:tag . "NN") (:stem . "mu/kappa") (:form . "mu/kappa") (:end . 203)\n  (:start . 195) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1160.5) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010797@unknown@formal@none@1@S@Lysates from CD19 cross-linked 1E8 cells induced robust phosphorylation of an Elk-1 fusion protein in vitro, whereas no phosphorylation of Elk-1 fusion protein occurred using lysates from CD19 cross-linked BLIN-1 cells.@(((:tag . "NNS") (:stem . "lysate") (:form . "Lysates") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cross-linked") (:form . "cross-linked") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "1e8") (:form . "1E8") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "robust") (:form . "robust") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 71) (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "elk-1") (:form . "Elk-1") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 135) (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "elk-1") (:form . "Elk-1") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 151)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 174) (:start . 169)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 182)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 187) (:start . 183)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cross-linked") (:form . "cross-linked") (:end . 205)\n  (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "blin-1") (:form . "BLIN-1") (:end . 212)\n  (:start . 206) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 218)\n  (:start . 213) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1160.6.1) (:span 117 119)))\n (:nscopes ((:id . :x1160.6.1) (:span 117 218)))\n (:identifiers (:sid . :s1160.6) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010798@unknown@formal@none@1@S@An electrophoretic mobility shift assay employing AP-1 and NF-kappaB consensus oligonucleotides was used to demonstrate that AP-1 -binding activity increased, while constitutive NF-kappaB-binding activity was not enhanced, following 2 h of CD19 cross-linking in 1E8 cells.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 18) (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "employ") (:form . "employing") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "NNS") (:stem . "oligonucleotide") (:form . "oligonucleotides")\n  (:end . 95) (:start . 79) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 104) (:start . 100)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "VB") (:stem . "demonstrate") (:form . "demonstrate") (:end . 119)\n  (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "-binding") (:form . "-binding") (:end . 138)\n  (:start . 130) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 147)\n  (:start . 139) (:id . 60))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 157)\n  (:start . 148) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 62))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 164)\n  (:start . 159) (:id . 63))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 177)\n  (:start . 165) (:id . 64))\n ((:tag . "JJ") (:stem . "nf-kappab-binding") (:form . "NF-kappaB-binding")\n  (:end . 195) (:start . 178) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 204)\n  (:start . 196) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 208) (:start . 205)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 212) (:start . 209)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 221)\n  (:start . 213) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 232)\n  (:start . 223) (:id . 71))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 234) (:start . 233)\n  (:id . 72))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 236) (:start . 235)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 244) (:start . 240)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 258) (:start . 245) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 261) (:start . 259)\n  (:id . 77))\n ((:tag . "NN") (:stem . "1e8") (:form . "1E8") (:end . 265) (:start . 262)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 271)\n  (:start . 266) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x1160.7.1) (:span 209 212)))\n (:nscopes ((:id . :x1160.7.1) (:span 165 221)))\n (:identifiers (:sid . :s1160.7) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010800@unknown@formal@none@1@S@In contrast, CD19 cross-linking in BLIN-1 cells resulted in the induction of NF-kappaB, but had no apparent effect on AP-1-binding activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd19") (:form . "CD19") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "blin-1") (:form . "BLIN-1") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ap-1-binding") (:form . "AP-1-binding") (:end . 130)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1160.9.1) (:span 96 98)))\n (:nscopes ((:id . :x1160.9.1) (:span 96 139)))\n (:identifiers (:sid . :s1160.9) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010801@unknown@formal@none@1@S@These data suggest that CD19-mediated signal transduction activates different transcription factors at juxtaposed stages of B cell development that may culminate in the activation or suppression of distinct sets of genes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cd19-mediated") (:form . "CD19-mediated")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 99)\n  (:start . 92) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 102) (:start . 100)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "juxtapose") (:form . "juxtaposed") (:end . 113)\n  (:start . 103) (:id . 54))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 120)\n  (:start . 114) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 125) (:start . 124)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 142)\n  (:start . 131) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 151) (:start . 148)\n  (:id . 61))\n ((:tag . "VB") (:stem . "culminate") (:form . "culminate") (:end . 161)\n  (:start . 152) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 179)\n  (:start . 169) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 182) (:start . 180)\n  (:id . 66))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 194)\n  (:start . 183) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 206)\n  (:start . 198) (:id . 69))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 211) (:start . 207)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 214) (:start . 212)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 220)\n  (:start . 215) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1160.10.1) (:span 148 151))\n  ((:id . :x1160.10.2) (:span 11 18)))\n (:hscopes ((:id . :x1160.10.1) (:span 148 220))\n  ((:id . :x1160.10.2) (:span 11 220)))\n (:identifiers (:sid . :s1160.10) (:did . :|9548490|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010802@unknown@formal@none@1@S@Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "quasispecy") (:form . "quasispecies") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 99) (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 111)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 118)\n  (:start . 112) (:id . 57))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 130)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 139)\n  (:start . 134) (:id . 60))\n ((:tag . "JJ") (:stem . "glial") (:form . "glial") (:end . 145)\n  (:start . 140) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 167)\n  (:start . 156) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1161.1) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010803@unknown@formal@none@1@S@The generation of genomic diversity during the course of infection has the potential to affect all aspects of HIV-1 replication, including expression of the proviral genome.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 165)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 172)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1161.2) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010804@unknown@formal@none@1@S@To gain a better understanding of the impact of long terminal repeat (LTR) sequence diversity on LTR-directed gene expression in cells of the central nervous system (CNS) and immune system, we amplified and cloned LTRs from proviral DNA in HIV-1-infected peripheral blood.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 16) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ltr-directed") (:form . "LTR-directed") (:end . 109)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . "JJ") (:stem . "nervous") (:form . "nervous") (:end . 157)\n  (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cns") (:form . "CNS") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 181)\n  (:start . 175) (:id . 74))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 76))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 192) (:start . 190)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "amplify") (:form . "amplified") (:end . 202)\n  (:start . 193) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 213)\n  (:start . 207) (:id . 80))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 218) (:start . 214)\n  (:id . 81))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 223) (:start . 219)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 232)\n  (:start . 224) (:id . 83))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 236) (:start . 233)\n  (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 239) (:start . 237)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 254) (:start . 240) (:id . 86))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 265)\n  (:start . 255) (:id . 87))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 271)\n  (:start . 266) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s1161.3) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010805@unknown@formal@none@1@S@Sequence analysis of nineteen LTRs cloned from 2 adult and 3 pediatric patients revealed an average of 33 nucleotide changes (with respect to the sequence of the LAI LTR) within the 455-bp U3 region.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "CD") (:stem . "nineteen") (:form . "nineteen") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pediatric") (:form . "pediatric") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 177)\n  (:start . 171) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "455-bp") (:form . "455-bp") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 191) (:start . 189)\n  (:id . 76))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 198)\n  (:start . 192) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1161.4) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010806@unknown@formal@none@1@S@Transient expression analyses in cells of neuroglial and lymphocytic origin demonstrated that some of these LTRs had activities which varied significantly from the LAI LTR in U-373 MG cells (an astrocytoma cell line) as well as in Jurkat cells (a CD4-positive lymphocyte cell line).@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "neuroglial") (:form . 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5010807@unknown@formal@none@1@S@While LTRs which demonstrated the highest activities in U-373 MG cells also yielded high activities in Jurkat cells, the LTRs were generally more active in Jurkat cells when compared to the LAI LTR.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTRs") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "U-373") (:form . "U-373") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "MG") (:form . "MG") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "yield") (:form . "yielded") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "ltr") (:form . "LTRs") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "RB") (:stem . "generally") (:form . "generally") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 162)\n  (:start . 156) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 182)\n  (:start . 174) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "LAI") (:form . "LAI") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1161.6) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010808@unknown@formal@none@1@S@Differences in LTR sequence also resulted in differences in transcription factor recruitment to cis-acting sites within the U3 region of the LTR, as demonstrated by electrophoretic mobility shift assays.@(((:tag . "NNS") (:stem . "difference") (:form . "Differences") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 92)\n  (:start . 81) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 119)\n  (:start . 113) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 133)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 161)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 180) (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 189)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 195)\n  (:start . 190) (:id . 70))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 202)\n  (:start . 196) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1161.7) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010810@unknown@formal@none@1@S@These findings suggest that LTR sequence changes can significantly affect basal LTR function and transcription factor recruitment, which may, in turn, alter the course of viral replication in cells of CNS and immune system origin.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 73)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 129)\n  (:start . 118) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "alter") (:form . "alter") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 167)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 188)\n  (:start . 177) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cns") (:form . "CNS") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 215)\n  (:start . 209) (:id . 77))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 222)\n  (:start . 216) (:id . 78))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 229)\n  (:start . 223) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1161.9.1) (:span 137 140))\n  ((:id . :x1161.9.2) (:span 15 22)))\n (:hscopes ((:id . :x1161.9.1) (:span 137 229))\n  ((:id . :x1161.9.2) (:span 15 229)))\n (:identifiers (:sid . :s1161.9) (:did . :|9570512|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010811@unknown@formal@none@1@S@Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "attenuate") (:form . "attenuates") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 90)\n  (:start . 82) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1162.1) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010812@unknown@formal@none@1@S@Death-inducing ligands (DILs) such as tumor necrosis factor alpha (TNFalpha) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor kappaB (NFkappaB)-dependent program that may rescue cells from apoptosis induction.@(((:tag . "JJ") (:stem . "death-inducing") (:form . "Death-inducing")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 22)\n  (:start . 15) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DIL") (:form . "DILs") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 93)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "doxorubicin") (:form . "doxorubicin") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 148)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NFkappaB)-dependent")\n  (:form . "NFkappaB)-dependent") (:end . 183) (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 196) (:start . 192)\n  (:id . 73))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 207)\n  (:start . 201) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 218) (:start . 214)\n  (:id . 77))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 228)\n  (:start . 219) (:id . 78))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 238)\n  (:start . 229) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1162.2.1) (:span 197 200)))\n (:hscopes ((:id . :x1162.2.1) (:span 197 238)))\n (:identifiers (:sid . :s1162.2) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010813@unknown@formal@none@1@S@We demonstrate here that TRAIL (TNF-related apoptosis-inducing ligand), a recently identified DIL, also activates NFkappaB in lymphoid cell lines in a kinetic similar to TNFalpha.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TRAIL") (:form . "TRAIL") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "tnf-related") (:form . "TNF-related") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "apoptosis-inducing") (:form . "apoptosis-inducing")\n  (:end . 62) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "NNP") (:stem . "DIL") (:form . "DIL") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "nfkappab") (:form . "NFkappaB") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "kinetic") (:form . "kinetic") (:end . 158)\n  (:start . 151) (:id . 67))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 166)\n  (:start . 159) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 178)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1162.3) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010814@unknown@formal@none@1@S@NFkappaB activity is independent from FADD, caspases, and apoptosis induction.@(((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FADD") (:form . "FADD") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1162.4) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010815@unknown@formal@none@1@S@To study the influence of NFkappaB activity on apoptosis mediated by TRAIL, CD95, TNFalpha, or doxorubicin, NFkappaB activation was inhibited using the proteasome inhibitor N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal or transient overexpression of mutant IkappaBalpha.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TRAIL") (:form . "TRAIL") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "doxorubicin") (:form . "doxorubicin") (:end . 106)\n  (:start . 95) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 116)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 141)\n  (:start . 132) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 147) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 162)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "JJ") (:stem . "n-acetyl-l-leucinyl-l-leucinyl-l-norleucinal")\n  (:form . "N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal") (:end . 217)\n  (:start . 173) (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 220) (:start . 218)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 230)\n  (:start . 221) (:id . 72))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 245) (:start . 231) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 255)\n  (:start . 249) (:id . 75))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 268) (:start . 256) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1162.5) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010816@unknown@formal@none@1@S@Sensitivity for induction of apoptosis was markedly increased by these treatments in apoptosis sensitive cell lines.@(((:tag . "NN") (:stem . "sensitivity") (:form . "Sensitivity") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "treatment") (:form . "treatments") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1162.6) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010817@unknown@formal@none@1@S@Moreover, both in cell lines and in primary leukemia cells that are resistant towards induction of apoptosis by DILs and doxorubicin, antagonization of NFkappaB activity partially restored apoptosis sensitivity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "dil") (:form . "DILs") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "doxorubicin") (:form . "doxorubicin") (:end . 132)\n  (:start . 121) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "antagonization") (:form . "antagonization")\n  (:end . 148) (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 160)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 198)\n  (:start . 189) (:id . 71))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 210)\n  (:start . 199) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1162.7) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010818@unknown@formal@none@1@S@These data suggest that inhibition of NFkappaB activation may provide a molecular approach to increase apoptosis sensitivity in anticancer treatment.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "anticancer") (:form . "anticancer") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 148)\n  (:start . 139) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1162.8.1) (:span 58 61))\n  ((:id . :x1162.8.2) (:span 11 18)))\n (:hscopes ((:id . :x1162.8.1) (:span 58 148))\n  ((:id . :x1162.8.2) (:span 11 148)))\n (:identifiers (:sid . :s1162.8) (:did . :|9616159|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010820@unknown@formal@none@1@S@The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor kappaB (NF-kappaB), activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 166)\n  (:start . 158) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 173)\n  (:start . 168) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 74))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 180)\n  (:start . 175) (:id . 75))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 186)\n  (:start . 181) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 191) (:start . 187)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 201) (:start . 197)\n  (:id . 80))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 215) (:start . 202) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1163.2) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010821@unknown@formal@none@1@S@In the present study, the role of IL-2R signaling in the growth of CD8+ T cell prolymphocytic leukemia (T-PLL) cells has been investigated.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-2R") (:form . "IL-2R") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 49)\n  (:start . 40) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "prolymphocytic") (:form . "prolymphocytic")\n  (:end . 93) (:start . 79) (:id . 59))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "T-PLL") (:form . "T-PLL") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 116)\n  (:start . 111) (:id . 64))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 125) (:start . 121)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 138)\n  (:start . 126) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1163.3) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010822@unknown@formal@none@1@S@Flow cytometry revealed that primary leukemia cells from a patient with CD8+ T-PLL expressed IL-2Ralpha and beta chains, and the cells showed a proliferative response and an increase in IL-2Ralpha expression on culture with exogeneous IL-2.@(((:tag . "NNP") (:stem . "Flow") (:form . "Flow") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "T-PLL") (:form . "T-PLL") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 157) (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 166)\n  (:start . 158) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 182)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL-2Ralpha") (:form . "IL-2Ralpha") (:end . 196)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 207)\n  (:start . 197) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 210) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 218)\n  (:start . 211) (:id . 75))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 223) (:start . 219)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "exogeneous") (:form . "exogeneous") (:end . 234)\n  (:start . 224) (:id . 77))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 239) (:start . 235)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1163.4) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010823@unknown@formal@none@1@S@Northern blot analysis failed to detect IL-2 mRNA, suggesting that IL-2 may act in a paracrine manner in vivo.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "paracrine") (:form . "paracrine") (:end . 94)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1163.5.1) (:span 72 75))\n  ((:id . :x1163.5.2) (:span 51 61)))\n (:ncues ((:id . :x1163.5.3) (:span 23 29)))\n (:hscopes ((:id . :x1163.5.1) (:span 72 109))\n  ((:id . :x1163.5.2) (:span 51 109)))\n (:nscopes ((:id . :x1163.5.3) (:span 23 49)))\n (:identifiers (:sid . :s1163.5) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010824@unknown@formal@none@1@S@Electrophoretic mobility-shift assays revealed that recombinant IL-2 increased NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mobility-shift") (:form . "mobility-shift")\n  (:end . 30) (:start . 16) (:id . 43))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 44))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 46)\n  (:start . 38) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 63)\n  (:start . 52) (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 68) (:start . 64)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 78)\n  (:start . 69) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 88)\n  (:start . 79) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 105)\n  (:start . 97) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 116)\n  (:start . 109) (:id . 54))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 125)\n  (:start . 117) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 141)\n  (:start . 133) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 61))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 161)\n  (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 166) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 175)\n  (:start . 167) (:id . 64))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 182)\n  (:start . 176) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 192) (:start . 188)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 202)\n  (:start . 193) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 69))\n ((:tag . "NN") (:stem . "abundance") (:form . "abundance") (:end . 216)\n  (:start . 207) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 225)\n  (:start . 220) (:id . 72))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 234)\n  (:start . 226) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 248)\n  (:start . 239) (:id . 75))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 259)\n  (:start . 249) (:id . 76))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 265)\n  (:start . 260) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 269) (:start . 266)\n  (:id . 78))\n ((:tag . "NN") (:stem . "kbf1") (:form . "KBF1") (:end . 274) (:start . 270)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 277) (:start . 275)\n  (:id . 80))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 283)\n  (:start . 278) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 289)\n  (:start . 284) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1163.6) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010825@unknown@formal@none@1@S@IL-2 binding analysis demonstrated that IL-2 markedly increased the number of low affinity IL-2Rs on the leukemia cells, without an effect on the number of high-affinity IL-2Rs.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "il-2r") (:form . "IL-2Rs") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 169) (:start . 156) (:id . 68))\n ((:tag . "NNS") (:stem . "il-2r") (:form . "IL-2Rs") (:end . 176)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1163.7.1) (:span 121 128)))\n (:nscopes ((:id . :x1163.7.1) (:span 121 176)))\n (:identifiers (:sid . :s1163.7) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010826@unknown@formal@none@1@S@These results show that IL-2 is capable of inducing the nuclear expression of NF-kappaB in primary CD8+ T-PLL cells, and that this effect is mediated, at least in part, at a pretranslational level.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "JJ") (:stem . "cd8+") (:form . "CD8+") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t-pll") (:form . "T-PLL") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 137)\n  (:start . 131) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 149)\n  (:start . 141) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 159)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 167) (:start . 163)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 171) (:start . 169)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "pretranslational") (:form . "pretranslational")\n  (:end . 190) (:start . 174) (:id . 76))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 196)\n  (:start . 191) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1163.8) (:did . :|9619918|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010827@unknown@formal@none@1@S@The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "toll") (:form . "toll") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "JNK/SAPK") (:form . "JNK/SAPK") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 147) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 154)\n  (:start . 148) (:id . 62))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 156) (:start . 155)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TRAF6") (:form . "TRAF6") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1164.1) (:did . :|9625770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010828@unknown@formal@none@1@S@The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "homologue") (:form . "homologue") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "htoll") (:form . "hToll") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 95)\n  (:start . 84) (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-1R") (:form . "IL-1R") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 126)\n  (:start . 115) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 140) (:start . 136)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 151)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 169)\n  (:start . 159) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "adaptive") (:form . "adaptive") (:end . 181)\n  (:start . 173) (:id . 74))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 190)\n  (:start . 182) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1164.2) (:did . :|9625770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010830@unknown@formal@none@1@S@Tumor necrosis factor receptor-activated factor 6 (TRAF6) and the nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) are both involved in subsequent steps of NF-kappaB activation.@(((:tag . "NN") (:stem . "tumor") (:form . "Tumor") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "receptor-activated") (:form . "receptor-activated")\n  (:end . 40) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 47)\n  (:start . 41) (:id . 46))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TRAF6") (:form . "TRAF6") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB)-inducing")\n  (:form . "NF-kappaB)-inducing") (:end . 108) (:start . 89) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 183)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1164.4) (:did . :|9625770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010831@unknown@formal@none@1@S@Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TRAF6") (:form . "TRAF6") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "htoll-induced") (:form . "hToll-induced")\n  (:end . 78) (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "stress-activated") (:form . "stress-activated")\n  (:end . 109) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "kinase/c-jun") (:form . "kinase/c-Jun") (:end . 130)\n  (:start . 118) (:id . 58))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 143)\n  (:start . 131) (:id . 59))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 151)\n  (:start . 144) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 61))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 157) (:start . 153)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 168)\n  (:start . 158) (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 177)\n  (:start . 172) (:id . 65))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 188)\n  (:start . 178) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 199) (:start . 196)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 208)\n  (:start . 200) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1164.5.1) (:span 158 168)))\n (:ncues ((:id . :x1164.5.2) (:span 49 55)))\n (:hscopes ((:id . :x1164.5.1) (:span 158 208)))\n (:nscopes ((:id . :x1164.5.2) (:span 49 151)))\n (:identifiers (:sid . :s1164.5) (:did . :|9625770|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010832@unknown@formal@none@1@S@Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.@(((:tag . "NNP") (:stem . "Coactivation") (:form . "Coactivation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "cofactor") (:form . "cofactors") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1165.1) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010833@unknown@formal@none@1@S@Molecular dissection of the B-cell-specific transcription coactivator OCA-B has revealed distinct regions important, respectively, for recruitment to immunoglobulin promoters through interaction with octamer-bound Oct-1 and for subsequent coactivator function.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dissection") (:form . "dissection") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 43) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 69)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 75) (:start . 70)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 79) (:start . 76)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 88)\n  (:start . 80) (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 97)\n  (:start . 89) (:id . 52))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 105)\n  (:start . 98) (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 115)\n  (:start . 106) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 55))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 129)\n  (:start . 117) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 58))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 146)\n  (:start . 135) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 60))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 164) (:start . 150) (:id . 61))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 174)\n  (:start . 165) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 182)\n  (:start . 175) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 194)\n  (:start . 183) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "octamer-bound") (:form . "octamer-bound")\n  (:end . 213) (:start . 200) (:id . 66))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 219)\n  (:start . 214) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 223) (:start . 220)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 227) (:start . 224)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 238)\n  (:start . 228) (:id . 70))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 250)\n  (:start . 239) (:id . 71))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 259)\n  (:start . 251) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1165.2) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010834@unknown@formal@none@1@S@Further analysis of general coactivator requirements showed that selective removal of PC4 from the essential USA fraction severely impairs Oct-1 and OCA-B function in a cell-free system reconstituted with partially purified factors.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 59) (:start . 53)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 82)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . "NNP") (:stem . "USA") (:form . "USA") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 121)\n  (:start . 113) (:id . 58))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "oct-1") (:form . "Oct-1") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "NN") (:stem . "oca-b") (:form . "OCA-B") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 163)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 185)\n  (:start . 179) (:id . 68))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 199) (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 204) (:start . 200)\n  (:id . 70))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 214)\n  (:start . 205) (:id . 71))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 223)\n  (:start . 215) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 231)\n  (:start . 224) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1165.3) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010835@unknown@formal@none@1@S@Full activity can be restored by the combined action of recombinant PC4 and the PC4-depleted USA fraction, thus suggesting a joint requirement for PC4 and another, USA-derived component(s) for optimal function of Oct-1/OCA-B in the reconstituted system.@(((:tag . "JJ") (:stem . "full") (:form . "Full") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "restore") (:form . "restored") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pc4-depleted") (:form . "PC4-depleted") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "NNP") (:stem . "USA") (:form . "USA") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "joint") (:form . "joint") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 142)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "usa-derived") (:form . "USA-derived") (:end . 175)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "component(s)") (:form . "component(s)") (:end . 188)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 200)\n  (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 209)\n  (:start . 201) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 75))\n ((:tag . "NN") (:stem . "oct-1/oca-b") (:form . "Oct-1/OCA-B") (:end . 224)\n  (:start . 213) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 245) (:start . 232) (:id . 79))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 252)\n  (:start . 246) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1165.4.1) (:span 112 122)))\n (:hscopes ((:id . :x1165.4.1) (:span 112 252)))\n (:identifiers (:sid . :s1165.4) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010836@unknown@formal@none@1@S@Indeed, USA-derived PC2 was found to act synergistically with PC4 in reproducing the function of intact USA in the assay system.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "usa-derived") (:form . "USA-derived") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "pc2") (:form . "PC2") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 56) (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "reproduce") (:form . "reproducing") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "NNP") (:stem . "USA") (:form . "USA") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1165.5) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010837@unknown@formal@none@1@S@Consistent with the requirement for PC4 in the reconstituted system, OCA-B was found to interact directly with PC4.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "reconstitute") (:form . "reconstituted")\n  (:end . 60) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "OCA-B") (:form . "OCA-B") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1165.6) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010838@unknown@formal@none@1@S@Surprisingly, however, removal of PC4 from the unfractionated nuclear extract has no detrimental effect on OCA-B/Oct-1-dependent transcription.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pc4") (:form . "PC4") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unfractionated") (:form . "unfractionated")\n  (:end . 61) (:start . 47) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "extract") (:form . "extract") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "detrimental") (:form . "detrimental") (:end . 96)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "oca-b/oct-1-dependent")\n  (:form . "OCA-B/Oct-1-dependent") (:end . 128) (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 142) (:start . 129) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1165.7.1) (:span 82 84)))\n (:nscopes ((:id . :x1165.7.1) (:span 82 142)))\n (:identifiers (:sid . :s1165.7) (:did . :|9632764|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010840@unknown@formal@none@1@S@Limited proteolysis for assaying ligand binding affinities of nuclear receptors.@(((:tag . "VBN") (:stem . "limit") (:form . "Limited") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "assay") (:form . "assaying") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "affinity") (:form . "affinities") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1166.1) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010841@unknown@formal@none@1@S@The binding of natural or synthetic ligands to nuclear receptors is the triggering event leading to gene transcription activation or repression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "trigger") (:form . "triggering") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 143)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1166.2) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010842@unknown@formal@none@1@S@Ligand binding to the ligand binding domain of these receptors induces conformational changes that are evidenced by an increased resistance of this domain to proteases.@(((:tag . "NNP") (:stem . "Ligand") (:form . "Ligand") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "JJ") (:stem . "conformational") (:form . "conformational")\n  (:end . 85) (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "evidence") (:form . "evidenced") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 154)\n  (:start . 148) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1166.3) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010843@unknown@formal@none@1@S@In vitro labeled receptors were incubated with various synthetic or natural agonists or antagonists and submitted to trypsin digestion.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "label") (:form . "labeled") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "antagonist") (:form . "antagonists") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "submit") (:form . "submitted") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "trypsin") (:form . "trypsin") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "digestion") (:form . "digestion") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1166.4) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010844@unknown@formal@none@1@S@Proteolysis products were separated by SDS-PAGE and quantified.@(((:tag . "NNP") (:stem . "Proteolysis") (:form . "Proteolysis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sds-page") (:form . "SDS-PAGE") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "quantify") (:form . "quantified") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1166.5) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010845@unknown@formal@none@1@S@The amount of trypsin-resistant fragments was proportional to receptor occupancy by the ligand, and allowed the determination of dissociation constants (kDa).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "trypsin-resistant") (:form . "trypsin-resistant")\n  (:end . 31) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "proportional") (:form . "proportional") (:end . 58)\n  (:start . 46) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "occupancy") (:form . "occupancy") (:end . 80)\n  (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 125) (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 141)\n  (:start . 129) (:id . 61))\n ((:tag . "NNS") (:stem . "constant") (:form . "constants") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1166.6) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010846@unknown@formal@none@1@S@Using the wild-type or mutated human retinoic acid receptor alpha as a model, kDa values determined by classical competition binding assays using tritiated ligands are in agreement with those measured by the proteolytic assay.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 145) (:start . 140)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "tritiate") (:form . "tritiated") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 180)\n  (:start . 171) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 200)\n  (:start . 192) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 219)\n  (:start . 208) (:id . 75))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1166.7) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010847@unknown@formal@none@1@S@This method was successfully extended to human retinoic X receptor alpha, glucocorticoid receptor, and progesterone receptor, thus providing a basis for a new, faster assay to determine simultaneously the affinity and conformation of receptors when bound to a given ligand.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "extend") (:form . "extended") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 115)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "JJR") (:stem . "fast") (:form . "faster") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 185)\n  (:start . 176) (:id . 72))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 200) (:start . 186) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 74))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 213)\n  (:start . 205) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 217) (:start . 214)\n  (:id . 76))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 230)\n  (:start . 218) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 243)\n  (:start . 234) (:id . 79))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 248) (:start . 244)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 254)\n  (:start . 249) (:id . 81))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 257) (:start . 255)\n  (:id . 82))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 259) (:start . 258)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 265)\n  (:start . 260) (:id . 84))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 272)\n  (:start . 266) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1166.8) (:did . :|9633826|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010848@unknown@formal@none@1@S@Mycobacterium tuberculosis mannose-capped lipoarabinomannan can induce NF-kappaB-dependent activation of human immunodeficiency virus type 1 long terminal repeat in T cells.@(((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 26)\n  (:start . 14) (:id . 43))\n ((:tag . "JJ") (:stem . "mannose-capped") (:form . "mannose-capped")\n  (:end . 41) (:start . 27) (:id . 44))\n ((:tag . "NN") (:stem . "lipoarabinomannan") (:form . "lipoarabinomannan")\n  (:end . 59) (:start . 42) (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 63) (:start . 60)\n  (:id . 46))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 70)\n  (:start . 64) (:id . 47))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 90) (:start . 71) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 101)\n  (:start . 91) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 110)\n  (:start . 105) (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 127) (:start . 111) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 133)\n  (:start . 128) (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 138) (:start . 134)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 140) (:start . 139)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 145) (:start . 141)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 154)\n  (:start . 146) (:id . 57))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 161)\n  (:start . 155) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 166) (:start . 165)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1167.1) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010850@unknown@formal@none@1@S@The major goal of this study was to determine whether the mycobacterial cell wall component mannose-capped lipoarabinomannan (ManLAM) of Mycobacterium tuberculosis (M. tuberculosis) could activate transcription of HIV-1 in T cells with the use of an in vitro cell culture system.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "goal") (:form . "goal") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mycobacterial") (:form . "mycobacterial")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "JJ") (:stem . "mannose-capped") (:form . "mannose-capped")\n  (:end . 106) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "lipoarabinomannan") (:form . "lipoarabinomannan")\n  (:end . 124) (:start . 107) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ManLAM") (:form . "ManLAM") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Mycobacterium") (:form . "Mycobacterium")\n  (:end . 150) (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 163)\n  (:start . 151) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 180)\n  (:start . 168) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 196)\n  (:start . 188) (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 210) (:start . 197) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 219)\n  (:start . 214) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 224) (:start . 223)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 230)\n  (:start . 225) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 235) (:start . 231)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 78))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 243) (:start . 240)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 80))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 249) (:start . 247)\n  (:id . 81))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 252) (:start . 250)\n  (:id . 82))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 258)\n  (:start . 253) (:id . 83))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 263) (:start . 259)\n  (:id . 84))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 271)\n  (:start . 264) (:id . 85))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 278)\n  (:start . 272) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x1167.3.1) (:span 46 53)))\n (:hscopes ((:id . :x1167.3.1) (:span 46 278)))\n (:identifiers (:sid . :s1167.3) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010851@unknown@formal@none@1@S@These experiments are of prime importance considering that CD4-expressing T lymphocytes represent the major virus reservoir in the peripheral blood of infected individuals.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "prime") (:form . "prime") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd4-expressing") (:form . "CD4-expressing")\n  (:end . 73) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 97)\n  (:start . 88) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "reservoir") (:form . "reservoir") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 141)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 171)\n  (:start . 160) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1167.4) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010852@unknown@formal@none@1@S@Using the 1G5 cell line harbouring the luciferase reporter gene under the control of the HIV-1 LTR, it was first found that culture protein filtrates (CFP) from M. tuberculosis or purified ManLAM could activate HIV-1 LTR-dependent gene expression unlike similarly prepared CFP extracts devoid of ManLAM.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "1g5") (:form . "1G5") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "harbour") (:form . "harbouring") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . 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5010853@unknown@formal@none@1@S@The implication of protein tyrosine kinase(s), protein kinase A and/or protein kinase C was highlighted by the abrogation of the ManLAM-mediated activation of HIV-1 LTR-driven gene expression using herbimycin A and H7.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "implication") (:form . "implication") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "kinase(s)") (:form . "kinase(s)") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "highlight") (:form . "highlighted") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "abrogation") (:form . "abrogation") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "manlam-mediated") (:form . "ManLAM-mediated")\n  (:end . 144) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "JJ") (:stem . "ltr-driven") (:form . "LTR-driven") (:end . 175)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 180) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 197) (:start . 192)\n  (:id . 70))\n ((:tag . "NN") (:stem . "herbimycin") (:form . "herbimycin") (:end . 208)\n  (:start . 198) (:id . 71))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 210) (:start . 209)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "H7") (:form . "H7") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1167.6) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010854@unknown@formal@none@1@S@It was also determined, using electrophoresis mobility shift assays, that M. tuberculosis ManLAM led to the nuclear translocation of the transcription factor NF-kappaB.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 45) (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "FW") (:stem . "m.") (:form . "M.") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "FW") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "NNP") (:stem . "ManLAM") (:form . "ManLAM") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 129) (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 150) (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 157)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 167)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1167.7) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010855@unknown@formal@none@1@S@M. tuberculosis ManLAM resulted in clear induction of the luciferase gene placed under the control of the wild-type, but not the kappaB-mutated, HIV-1 LTR region.@(((:tag . "FW") (:stem . "m.") (:form . "M.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "ManLAM") (:form . "ManLAM") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "place") (:form . "placed") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "kappab-mutated") (:form . "kappaB-mutated")\n  (:end . 143) (:start . 129) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1167.8.1) (:span 121 124)))\n (:nscopes ((:id . :x1167.8.1) (:span 121 143)))\n (:identifiers (:sid . :s1167.8) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010856@unknown@formal@none@1@S@Finally, the ManLAM-mediated activation of HIV-1 LTR transcription was found to be independent of the autocrine or paracrine action of endogenous TNF-alpha.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "manlam-mediated") (:form . "ManLAM-mediated")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 66) (:start . 53) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "autocrine") (:form . "autocrine") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "paracrine") (:form . "paracrine") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 131)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1167.9) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010857@unknown@formal@none@1@S@The results suggest that M. tuberculosis can upregulate HIV-1 expression in T cells and could thus have the potential to influence the pathogenesis of HIV-1 infection.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tuberculosis") (:form . "tuberculosis") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "upregulate") (:form . "upregulate") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 147)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 156)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 166)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1167.10.1) (:span 88 93))\n  ((:id . :x1167.10.2) (:span 12 19)))\n (:hscopes ((:id . :x1167.10.1) (:span 88 166))\n  ((:id . :x1167.10.2) (:span 12 166)))\n (:identifiers (:sid . :s1167.10) (:did . :|9634075|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010858@unknown@formal@none@1@S@Oxidative stress suppresses transcription factor activities in stimulated lymphocytes.@(((:tag . "JJ") (:stem . "oxidative") (:form . "Oxidative") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 46))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 59)\n  (:start . 49) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 73)\n  (:start . 63) (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 85)\n  (:start . 74) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1168.1) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010860@unknown@formal@none@1@S@Purified quiescent human blood T lymphocytes were subjected to: (i) acute exposure to hydrogen peroxide; (ii) chronic exposure to hydrogen peroxide; and (iii) acute exposure to ionizing radiation.@(((:tag . "VBN") (:stem . "purify") (:form . "Purified") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 117)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 126)\n  (:start . 118) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 138)\n  (:start . 130) (:id . 67))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 147)\n  (:start . 139) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 71))\n ((:tag . "LS") (:stem . "iii") (:form . "iii") (:end . 157) (:start . 154)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 164)\n  (:start . 159) (:id . 74))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 173)\n  (:start . 165) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 185)\n  (:start . 177) (:id . 77))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 195)\n  (:start . 186) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1168.3) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010861@unknown@formal@none@1@S@The cells were then stimulated for 6 h.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1168.4) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010862@unknown@formal@none@1@S@DNA-binding activities (determined by the electrophoretic mobility shift assay) of three transcription factors: NFkappaB, AP-1 and NFAT, were abolished in the lymphocytes by all three modes of oxidative stress.@(((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 22)\n  (:start . 12) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 57) (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 72) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 170)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 177) (:start . 174)\n  (:id . 70))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . "NNS") (:stem . "mode") (:form . "modes") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 202)\n  (:start . 193) (:id . 74))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 209)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1168.5) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010863@unknown@formal@none@1@S@The lymphocytes exhibited lipid peroxidation only upon exposure to the lowest level of hydrogen peroxide used (20 microM).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "peroxidation") (:form . "peroxidation") (:end . 44)\n  (:start . 32) (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 49) (:start . 45)\n  (:id . 47))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "low") (:form . "lowest") (:end . 77) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1168.6) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010864@unknown@formal@none@1@S@All three modes of oxidative stress induced catalase activity in the lymphocytes.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mode") (:form . "modes") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1168.7) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010865@unknown@formal@none@1@S@The only exception was hydrogen peroxide at 20 microM, which did not induce catalase activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hydrogen") (:form . "hydrogen") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "peroxide") (:form . "peroxide") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1168.8.1) (:span 65 68)))\n (:nscopes ((:id . :x1168.8.1) (:span 65 93)))\n (:identifiers (:sid . :s1168.8) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010866@unknown@formal@none@1@S@We conclude that: (i) suppression of specific transcription factor functions can potentially serve as a marker of exposure to oxidative stress and its effects on human lymphocytes; (ii) lipid peroxidation is only detectable in human lymphocytes upon exposure to weak oxidative stress which does not induce catalase activity; (iii) therefore, transcription factor DNA-binding activities are more sensitive to oxidative stress than lipid peroxidation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "LS") (:stem . "i") (:form . 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"more") (:end . 394) (:start . 390)\n  (:id . 107))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 404)\n  (:start . 395) (:id . 108))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 407) (:start . 405)\n  (:id . 109))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 417)\n  (:start . 408) (:id . 110))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 424)\n  (:start . 418) (:id . 111))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 429) (:start . 425)\n  (:id . 112))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 435)\n  (:start . 430) (:id . 113))\n ((:tag . "NN") (:stem . "peroxidation") (:form . "peroxidation") (:end . 448)\n  (:start . 436) (:id . 114))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 449) (:start . 448)\n  (:id . 115)))@@@1@74@((:hcues ((:id . :x1168.9.2) (:span 81 92)))\n (:ncues ((:id . :x1168.9.1) (:span 295 298)))\n (:hscopes ((:id . :x1168.9.2) (:span 81 179)))\n (:nscopes ((:id . :x1168.9.1) (:span 295 323)))\n (:identifiers (:sid . :s1168.9) (:did . :|9649186|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010867@unknown@formal@none@1@S@DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "damaging") (:form . "damaging") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1169.1) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010868@unknown@formal@none@1@S@Apoptosis induced by DNA damage and other stresses can proceed via expression of Fas ligand (FasL) and ligation of its receptor, Fas (CD95).@(((:tag . "NNP") (:stem . "Apoptosis") (:form . "Apoptosis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "stress") (:form . "stresses") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VB") (:stem . "proceed") (:form . "proceed") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "CD95") (:form . "CD95") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1169.2) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010870@unknown@formal@none@1@S@A nondegradable mutant of I kappa B blocked both FasL expression and apoptosis induced by DNA damage but not Fas ligation.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nondegradable") (:form . "nondegradable")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fasl") (:form . "FasL") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1169.4.1) (:span 105 108)))\n (:nscopes ((:id . :x1169.4.1) (:span 105 121)))\n (:identifiers (:sid . :s1169.4) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010871@unknown@formal@none@1@S@These stimuli also induced the stress-activated kinase pathway (SAPK/JNK), which was required for the maximal induction of apoptosis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "stress-activated") (:form . "stress-activated")\n  (:end . 47) (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SAPK/JNK") (:form . "SAPK/JNK") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1169.5) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010872@unknown@formal@none@1@S@A 1.2 kb FasL promoter responded to DNA damage, as well as coexpression with p65 Rel or Fos/Jun.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1.2") (:form . "1.2") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 22)\n  (:start . 14) (:id . 46))\n ((:tag . "VBD") (:stem . "respond") (:form . "responded") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 71)\n  (:start . 59) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Fos/Jun") (:form . "Fos/Jun") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1169.6) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010873@unknown@formal@none@1@S@Mutations in the relevant NF-kappa B and AP-1 binding sites eliminated these responses.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "eliminate") (:form . "eliminated") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1169.7) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010874@unknown@formal@none@1@S@Thus, activation of NF-kappa B and AP-1 contributes to stress-induced apoptosis via the expression of FasL.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 51)\n  (:start . 40) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "stress-induced") (:form . "stress-induced")\n  (:end . 69) (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1169.8) (:did . :|9660938|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010875@unknown@formal@none@1@S@Thrombopoietin supports in vitro erythroid differentiation via its specific receptor c-Mpl in a human leukemia cell line.@(((:tag . "NNP") (:stem . "Thrombopoietin") (:form . "Thrombopoietin")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 58) (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 62) (:start . 59)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 84)\n  (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "c-mpl") (:form . "c-Mpl") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1170.1) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010876@unknown@formal@none@1@S@Thrombopoietin (TPO) acts on megakaryopoiesis and erythropoiesis in vitro and in vivo.@(((:tag . "NNP") (:stem . "Thrombopoietin") (:form . "Thrombopoietin")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "megakaryopoiesis") (:form . "megakaryopoiesis")\n  (:end . 45) (:start . 29) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1170.2) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010877@unknown@formal@none@1@S@We isolated a novel subline, UT-7/GMT, from the human leukemia cell line UT-7/GM (N. Komatsu, et al., Blood, 89: 4021-4033, 1997).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "isolate") (:form . "isolated") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "subline") (:form . "subline") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "UT-7/GMT") (:form . "UT-7/GMT") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "UT-7/GM") (:form . "UT-7/GM") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "N.") (:form . "N.") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Komatsu") (:form . "Komatsu") (:end . 92)\n  (:start . 85) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Blood") (:form . "Blood") (:end . 107)\n  (:start . 102) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 65))\n ((:tag . "CD") (:stem . "89") (:form . "89") (:end . 111) (:start . 109)\n  (:id . 66))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 112) (:start . 111)\n  (:id . 67))\n ((:tag . "CD") (:stem . "4021-4033") (:form . "4021-4033") (:end . 122)\n  (:start . 113) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1997") (:form . "1997") (:end . 128) (:start . 124)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1170.3) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010878@unknown@formal@none@1@S@A small population of UT-7/GM cells positively stained for hemoglobin (Hb) after a 7-day exposure to TPO.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "UT-7/GM") (:form . "UT-7/GM") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hemoglobin") (:form . "hemoglobin") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Hb") (:form . "Hb") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "7-day") (:form . "7-day") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1170.4) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010880@unknown@formal@none@1@S@Using UT-7/GMT cells, we examined how TPO promotes hemoglobinization.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ut-7/gmt") (:form . "UT-7/GMT") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "hemoglobinization") (:form . "hemoglobinization")\n  (:end . 68) (:start . 51) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1170.6) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010881@unknown@formal@none@1@S@TPO induced tyrosine phosphorylation of the TPO receptor but not the erythropoietin (EPO) receptor.@(((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 36) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 83) (:start . 69) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1170.7.1) (:span 61 64)))\n (:nscopes ((:id . :x1170.7.1) (:span 61 98)))\n (:identifiers (:sid . :s1170.7) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010882@unknown@formal@none@1@S@There was no competition between TPO and EPO for binding to EPO receptor.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "competition") (:form . "competition") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1170.8.1) (:span 10 12)))\n (:nscopes ((:id . :x1170.8.1) (:span 10 72)))\n (:identifiers (:sid . :s1170.8) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010883@unknown@formal@none@1@S@These findings suggest that TPO has a direct effect on hemoglobinization via a specific receptor on UT-7/GMT cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hemoglobinization") (:form . "hemoglobinization")\n  (:end . 72) (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "UT-7/GMT") (:form . "UT-7/GMT") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1170.9.1) (:span 15 22)))\n (:hscopes ((:id . :x1170.9.1) (:span 15 114)))\n (:identifiers (:sid . :s1170.9) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010884@unknown@formal@none@1@S@Isoelectric focusing demonstrated that TPO induced fetal and adult Hb synthesis, whereas EPO induced embryonic, fetal, and adult Hb synthesis.@(((:tag . "JJ") (:stem . "isoelectric") (:form . "Isoelectric") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "focusing") (:form . "focusing") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 56) (:start . 51)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Hb") (:form . "Hb") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NNP") (:stem . "EPO") (:form . "EPO") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NNP") (:stem . "Hb") (:form . "Hb") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1170.10) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010885@unknown@formal@none@1@S@Thus, our data suggest that TPO has a distinct action on erythropoiesis.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 46)\n  (:start . 38) (:id . 51))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "erythropoiesis") (:form . "erythropoiesis")\n  (:end . 71) (:start . 57) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1170.11.1) (:span 15 22)))\n (:hscopes ((:id . :x1170.11.1) (:span 15 71)))\n (:identifiers (:sid . :s1170.11) (:did . :|9663467|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010886@unknown@formal@none@1@S@Redox signals and NF-kappaB activation in T cells.@(((:tag . "NNP") (:stem . "Redox") (:form . "Redox") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1171.1) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010887@unknown@formal@none@1@S@Accumulating data from a number of laboratories have recently indicated that the response of transcription factor NF-kappaB to alterations in the redox homeostasis of cells may play an important role in modulating immune function.@(((:tag . "VBG") (:stem . "accumulate") (:form . "Accumulating") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "laboratory") (:form . "laboratories") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "alteration") (:form . "alterations") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 163)\n  (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 194)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 199) (:start . 195)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 213)\n  (:start . 203) (:id . 73))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 220)\n  (:start . 214) (:id . 74))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 229)\n  (:start . 221) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1171.2.1) (:span 173 176))\n  ((:id . :x1171.2.2) (:span 62 76)))\n (:hscopes ((:id . :x1171.2.1) (:span 173 229))\n  ((:id . :x1171.2.2) (:span 62 229)))\n (:identifiers (:sid . :s1171.2) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010888@unknown@formal@none@1@S@The activation of NF-kappaB has been recognized to regulate a number of genes necessary for normal T cell responses including IL-2, IL-6, IL-8, and several T cell surface receptors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 170)\n  (:start . 163) (:id . 72))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 180)\n  (:start . 171) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1171.3) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010890@unknown@formal@none@1@S@In addition, aberrancies in NF-kappaB activity have been implicated in the immunopathogenesis of diseases involving immune or inflammatory processes such as atherosclerosis and HIV-1 infection.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "aberrancy") (:form . "aberrancies") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "immunopathogenesis") (:form . "immunopathogenesis")\n  (:end . 93) (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 105)\n  (:start . 97) (:id . 56))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 115)\n  (:start . 106) (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 138)\n  (:start . 126) (:id . 60))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 148)\n  (:start . 139) (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 153) (:start . 149)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 172) (:start . 157) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 182)\n  (:start . 177) (:id . 66))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 192)\n  (:start . 183) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1171.5) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010891@unknown@formal@none@1@S@The role of H2O2 and other reactive oxygen species (ROS) as an integratory secondary messenger for divergent T cell signals has been complicated by the fact that various T cell lines and peripheral blood T cells differ markedly in the levels of NF-kappaB activation induced by oxidant stress.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . 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5010892@unknown@formal@none@1@S@Additionally, proposed pathways of NF-kappaB activation have been based on indirect evidence provided by experiments which used antioxidants to inhibit active NF-kappaB formation.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "antioxidant") (:form . "antioxidants") (:end . 140)\n  (:start . 128) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 168)\n  (:start . 159) (:id . 64))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 178)\n  (:start . 169) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1171.7) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010893@unknown@formal@none@1@S@Further, complete activation of T cells requires at least two signals, one that stimulates an increase in intracellular calcium and one that stimulates enzymatic processes including kinases.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 119) (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "calcium") (:form . "calcium") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 151)\n  (:start . 141) (:id . 66))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 161)\n  (:start . 152) (:id . 67))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 189)\n  (:start . 182) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1171.8) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010894@unknown@formal@none@1@S@Similarly, substantial evidence indicates that full activation of NF-kappaB requires dual signals.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1171.9.1) (:span 32 46)))\n (:hscopes ((:id . :x1171.9.1) (:span 32 97)))\n (:identifiers (:sid . :s1171.9) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010895@unknown@formal@none@1@S@The ability of H2O2 or other ROS to induce T cell signals and functional responses by these two mechanisms is reviewed and the specific response of NF-kappaB to redox changes in T cells is examined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ros") (:form . "ROS") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 57)\n  (:start . 50) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 72)\n  (:start . 62) (:id . 55))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 135)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 157)\n  (:start . 148) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 174)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 188) (:start . 186)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 197)\n  (:start . 189) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1171.10) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010896@unknown@formal@none@1@S@Data are also presented to suggest that the redox regulation in NF-kappaB activation may be relevant to immune-related diseases and to aging.@(((:tag . "NNPS") (:stem . "Datum") (:form . "Data") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune-related") (:form . "immune-related")\n  (:end . 118) (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1171.11.1) (:span 85 88))\n  ((:id . :x1171.11.2) (:span 27 34)))\n (:hscopes ((:id . :x1171.11.1) (:span 85 140))\n  ((:id . :x1171.11.2) (:span 27 140)))\n (:identifiers (:sid . :s1171.11) (:did . :|9680181|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010897@unknown@formal@none@1@S@Fibrinogen activates NF-kappa B transcription factors in mononuclear phagocytes.@(((:tag . "NNP") (:stem . "Fibrinogen") (:form . "Fibrinogen") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 53)\n  (:start . 46) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 68)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 79)\n  (:start . 69) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1172.1) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010898@unknown@formal@none@1@S@Adhesion to extracellular matrices is known to modulate leukocyte activation, although the mechanisms are not fully understood.@(((:tag . "NNP") (:stem . "Adhesion") (:form . "Adhesion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "matrix") (:form . "matrices") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 43) (:start . 38)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 126)\n  (:start . 116) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1172.2.1) (:span 106 126)))\n (:hscopes ((:id . :x1172.2.1) (:span 87 126)))\n (:identifiers (:sid . :s1172.2) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010900@unknown@formal@none@1@S@U937 cells differentiated with PMA in nonadherent culture were shown to express two fibrinogen-binding integrins, predominately CD11b/CD18, and to a lesser extent, CD11c/CD18.@(((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nonadherent") (:form . "nonadherent") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "fibrinogen-binding") (:form . "fibrinogen-binding")\n  (:end . 102) (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "integrin") (:form . "integrins") (:end . 112)\n  (:start . 103) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "RB") (:stem . "predominately") (:form . "predominately")\n  (:end . 127) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 155)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 162)\n  (:start . 156) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cd11c/cd18") (:form . "CD11c/CD18") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1172.4) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010901@unknown@formal@none@1@S@Cells stimulated with fibrinogen (10-100 microg/ml)/Mn2+ (50 microM) for 2 h were examined by electrophoretic mobility shift assay.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fibrinogen") (:form . "fibrinogen") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "CD") (:stem . "10-100") (:form . "10-100") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "microg/ml)/Mn2+") (:form . "microg/ml)/Mn2+")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 109) (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1172.5) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010902@unknown@formal@none@1@S@NF-kappa B activation, minimal in unstimulated cells, was substantially up-regulated by fibrinogen.@(((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fibrinogen") (:form . "fibrinogen") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1172.6) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010903@unknown@formal@none@1@S@Fibrinogen also caused activation of AP-1, but not SP1 or cAMP response element-binding protein (CREB) factors.@(((:tag . "NNP") (:stem . "Fibrinogen") (:form . "Fibrinogen") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 87) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1172.7.1) (:span 47 50)))\n (:nscopes ((:id . :x1172.7.1) (:span 47 110)))\n (:identifiers (:sid . :s1172.7) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010904@unknown@formal@none@1@S@Blocking mAbs against CD18 and CD11b abrogated fibrinogen-induced NF-kappa B activation.@(((:tag . "VBG") (:stem . "block") (:form . "Blocking") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mab") (:form . "mAbs") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "cd18") (:form . "CD18") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CD11b") (:form . "CD11b") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "abrogate") (:form . "abrogated") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "fibrinogen-induced") (:form . "fibrinogen-induced")\n  (:end . 65) (:start . 47) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1172.8) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010905@unknown@formal@none@1@S@To determine the effects on transcriptional regulation, U937 cells were transfected with a plasmid containing the HIV-1 enhancer (bearing two NF-kappa B sites) coupled to a chloramphenicol acetyltransferase (CAT) reporter.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 43) (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "bear") (:form . "bearing") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 152) (:start . 151)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 158)\n  (:start . 153) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "couple") (:form . "coupled") (:end . 167)\n  (:start . 160) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "chloramphenicol") (:form . "chloramphenicol")\n  (:end . 188) (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 206) (:start . 189) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "CAT") (:form . "CAT") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 75))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 221)\n  (:start . 213) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1172.9) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010906@unknown@formal@none@1@S@Cells were subsequently stimulated with 1) PMA for 24 h, inducing CAT activity by 2.6-fold, 2) fibrinogen/Mn2+ for 2 h, inducing CAT activity by 3.2-fold, or 3) costimulation with fibrinogen and PMA, inducing 5.7-fold the CAT activity induced by PMA alone.@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PMA") (:form . 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5010907@unknown@formal@none@1@S@We conclude that contact with fibrinogen-derived proteins may contribute to mononuclear phagocyte activation by signaling through CD11b/CD18, resulting in selective activation of transcriptional regulatory factors, including NF-kappa B.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "fibrinogen-derived") (:form . "fibrinogen-derived")\n  (:end . 48) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 72)\n  (:start . 62) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "phagocyte") (:form . "phagocyte") (:end . 97)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 108)\n  (:start . 98) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 121)\n  (:start . 112) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 129)\n  (:start . 122) (:id . 57))\n ((:tag . "NN") (:stem . "cd11b/cd18") (:form . "CD11b/CD18") (:end . 140)\n  (:start . 130) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 151)\n  (:start . 142) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 164)\n  (:start . 155) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 175)\n  (:start . 165) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 194) (:start . 179) (:id . 65))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 205)\n  (:start . 195) (:id . 66))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 213)\n  (:start . 206) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 224)\n  (:start . 215) (:id . 69))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 233)\n  (:start . 225) (:id . 70))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 235) (:start . 234)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1172.11.1) (:span 58 61)))\n (:hscopes ((:id . :x1172.11.1) (:span 58 235)))\n (:identifiers (:sid . :s1172.11) (:did . :|9686612|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010908@unknown@formal@none@1@S@Ex vivo activation of tumor-draining lymph node T cells reverses defects in signal transduction molecules.@(((:tag . "FW") (:stem . "ex") (:form . "Ex") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tumor-draining") (:form . "tumor-draining")\n  (:end . 36) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "reverse") (:form . "reverses") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 95)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1173.1) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010910@unknown@formal@none@1@S@The efficacy of the activated LN cells is augmented when the sensitizing tumor is a genetically modified variant (designated D5G6) that secretes granulocyte/macrophage-colony-stimulating factor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "ln") (:form . "LN") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "augment") (:form . "augmented") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "sensitize") (:form . "sensitizing") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "NNP") (:stem . "D5G6") (:form . "D5G6") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "secrete") (:form . "secretes") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "granulocyte/macrophage-colony-stimulating")\n  (:form . "granulocyte/macrophage-colony-stimulating") (:end . 186)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 193)\n  (:start . 187) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1173.3) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010911@unknown@formal@none@1@S@In contrast to anti-CD3/IL-2-activated LN cells, adoptive transfer of freshly isolated tumor-draining LN T cells has no therapeutic activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-cd3/il-2-activated")\n  (:form . "anti-CD3/IL-2-activated") (:end . 38) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "ln") (:form . "LN") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "adoptive") (:form . "adoptive") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 66)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "JJ") (:stem . "tumor-draining") (:form . "tumor-draining")\n  (:end . 101) (:start . 87) (:id . 54))\n ((:tag . "NNP") (:stem . "LN") (:form . "LN") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 131)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1173.4.1) (:span 117 119)))\n (:nscopes ((:id . :x1173.4.1) (:span 117 140)))\n (:identifiers (:sid . :s1173.4) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010912@unknown@formal@none@1@S@To determine whether the acquisition of antitumor function during ex vivo activation is associated with modifications in signal transduction capacity, the protein tyrosine kinases p56lck and p59fyn and proteins of the NF-kappaB family were analyzed in tumor-draining LN T cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "acquisition") (:form . "acquisition") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "antitumor") (:form . "antitumor") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 117) (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 140)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 149)\n  (:start . 141) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 64))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 171)\n  (:start . 163) (:id . 65))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 186)\n  (:start . 180) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 197)\n  (:start . 191) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 210)\n  (:start . 202) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 227)\n  (:start . 218) (:id . 74))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 234)\n  (:start . 228) (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 239) (:start . 235)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 248)\n  (:start . 240) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 251) (:start . 249)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "tumor-draining") (:form . "tumor-draining")\n  (:end . 266) (:start . 252) (:id . 79))\n ((:tag . "NNP") (:stem . "LN") (:form . "LN") (:end . 269) (:start . 267)\n  (:id . 80))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 271) (:start . 270)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 277)\n  (:start . 272) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1173.5.1) (:span 13 20)))\n (:hscopes ((:id . :x1173.5.1) (:span 13 149)))\n (:identifiers (:sid . :s1173.5) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010913@unknown@formal@none@1@S@The levels of p56lck and p59fyn were lower in tumor-draining than in normal LN T cells and production of tyrosine-phosphorylated substrates was markedly depressed following anti-CD3 stimulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "tumor-draining") (:form . "tumor-draining")\n  (:end . 60) (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "LN") (:form . "LN") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 101)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tyrosine-phosphorylated")\n  (:form . "tyrosine-phosphorylated") (:end . 128) (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "VBN") (:stem . "depress") (:form . "depressed") (:end . 162)\n  (:start . 153) (:id . 65))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 181)\n  (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 193)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1173.6) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010914@unknown@formal@none@1@S@After 5-day anti-CD3/IL-2 activation, levels of p56lck and p59fyn and protein tyrosine kinase activity increased.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "5-day") (:form . "5-day") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "anti-cd3/il-2") (:form . "anti-CD3/IL-2")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1173.7) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010915@unknown@formal@none@1@S@Interestingly, the levels of p56lck, p59fyn, and tyrosine kinase activity were higher in activated T cells derived from LN that drained D5G6 than they were in those from D5 tumors.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "p59fyn") (:form . "p59fyn") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 85) (:start . 79)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LN") (:form . "LN") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "drain") (:form . "drained") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "d5g6") (:form . "D5G6") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 155) (:start . 151)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 164)\n  (:start . 159) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 169) (:start . 165)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "D5") (:form . "D5") (:end . 172) (:start . 170)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 179)\n  (:start . 173) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1173.8) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010916@unknown@formal@none@1@S@In contrast, the cytoplasmic levels of c-Rel and Rel A were normal in freshly isolated tumor-draining LN, as was nuclear kappaB DNA-binding activity induced by anti-CD3 mAb or phorbol myristate acetate.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "JJ") (:stem . "tumor-draining") (:form . "tumor-draining")\n  (:end . 101) (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "ln") (:form . "LN") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 139)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 148)\n  (:start . 140) (:id . 66))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 168)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 175) (:start . 173)\n  (:id . 71))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 183)\n  (:start . 176) (:id . 72))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 193)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 201)\n  (:start . 194) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1173.9) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010917@unknown@formal@none@1@S@Stimulation of activated LN cells with D5 tumor cells induced the nuclear translocation of NF-kappaB.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "ln") (:form . "LN") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D5") (:form . "D5") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1173.10) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010918@unknown@formal@none@1@S@These findings indicate that the recovery of proteins mediating signal transduction through the T cell receptor/CD3 complex in LN T cells activated ex vivo was associated with the acquisition of antitumor function.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "recovery") (:form . "recovery") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "VBG") (:stem . "mediate") (:form . "mediating") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 83)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 91)\n  (:start . 84) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor/cd3") (:form . "receptor/CD3") (:end . 115)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 123)\n  (:start . 116) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "LN") (:form . "LN") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 147)\n  (:start . 138) (:id . 63))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 170)\n  (:start . 160) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "acquisition") (:form . "acquisition") (:end . 191)\n  (:start . 180) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "antitumor") (:form . "antitumor") (:end . 204)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 213)\n  (:start . 205) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1173.11.1) (:span 15 28)))\n (:hscopes ((:id . :x1173.11.1) (:span 15 213)))\n (:identifiers (:sid . :s1173.11) (:did . :|9690455|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010920@unknown@formal@none@1@S@MyD88, originally isolated as a myeloid differentiation primary response gene, is shown to act as an adaptor in interleukin-1 (IL-1) signaling by interacting with both the IL-1 receptor complex and IL-1 receptor-associated kinase (IRAK).@(((:tag . "NN") (:stem . "myd88") (:form . "MyD88") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "adaptor") (:form . "adaptor") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 125) (:start . 112) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 157)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 167) (:start . 163)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 185)\n  (:start . 177) (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 193)\n  (:start . 186) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 202) (:start . 198)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 222) (:start . 203) (:id . 77))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 229)\n  (:start . 223) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 235) (:start . 231)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 236) (:start . 235)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1174.2) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010921@unknown@formal@none@1@S@Mice generated by gene targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and cytokines in response to IL-1.@(((:tag . "NNS") (:stem . "mouse") (:form . "Mice") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "targeting") (:form . "targeting") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "lack") (:form . "lack") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "myd88") (:form . "MyD88") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 83) (:start . 70) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 119)\n  (:start . 114) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 142)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 154)\n  (:start . 146) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1174.3.1) (:span 36 40)))\n (:nscopes ((:id . :x1174.3.1) (:span 36 46)))\n (:identifiers (:sid . :s1174.3) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010922@unknown@formal@none@1@S@Increases in interferon-gamma production and natural killer cell activity in response to IL-18 are abrogated.@(((:tag . "NNS") (:stem . "increase") (:form . "Increases") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 29) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 40)\n  (:start . 30) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-18") (:form . "IL-18") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1174.4) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010923@unknown@formal@none@1@S@In vivo Th1 response is also impaired.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1174.5) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010924@unknown@formal@none@1@S@Furthermore, IL-18-induced activation of NF-kappaB and c-Jun N-terminal kinase (JNK) is blocked in MyD88-/- Th1-developing cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "il-18-induced") (:form . "IL-18-induced")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 78)\n  (:start . 72) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "JNK") (:form . "JNK") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "myd88-/-") (:form . "MyD88-/-") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "th1-developing") (:form . "Th1-developing")\n  (:end . 122) (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1174.6) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010925@unknown@formal@none@1@S@Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "myd88") (:form . "MyD88") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-18") (:form . "IL-18") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1174.7) (:did . :|9697844|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010926@unknown@formal@none@1@S@Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "virus-transforming") (:form . "virus-transforming")\n  (:end . 31) (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 39)\n  (:start . 32) (:id . 44))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 46)\n  (:start . 40) (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 56)\n  (:start . 47) (:id . 46))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 65)\n  (:start . 57) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 75) (:start . 74)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 85)\n  (:start . 76) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 99) (:start . 86) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 106)\n  (:start . 100) (:id . 52))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 116)\n  (:start . 107) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 124)\n  (:start . 117) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 134)\n  (:start . 127) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 139) (:start . 135)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 148)\n  (:start . 140) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappaB-inducing") (:form . "NF-kappaB-inducing")\n  (:end . 171) (:start . 153) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 178)\n  (:start . 172) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 194)\n  (:start . 187) (:id . 64))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 202)\n  (:start . 195) (:id . 65))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 211)\n  (:start . 203) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 223)\n  (:start . 216) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1175.1) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010927@unknown@formal@none@1@S@The Epstein-Barr virus oncoprotein latent infection membrane protein 1 (LMP1) is a constitutively aggregated pseudo-tumor necrosis factor receptor (TNFR) that activates transcription factor NF-kappaB through two sites in its C-terminal cytoplasmic domain.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oncoprotein") (:form . "oncoprotein") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 97) (:start . 83) (:id . 56))\n ((:tag . "VBN") (:stem . "aggregate") (:form . "aggregated") (:end . 108)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "pseudo-tumor") (:form . "pseudo-tumor") (:end . 121)\n  (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 137)\n  (:start . 131) (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNFR") (:form . "TNFR") (:end . 152) (:start . 148)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 168)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 182) (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 189)\n  (:start . 183) (:id . 68))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 199)\n  (:start . 190) (:id . 69))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 207)\n  (:start . 200) (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 211) (:start . 208)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 217)\n  (:start . 212) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 224) (:start . 221)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 235)\n  (:start . 225) (:id . 75))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 247)\n  (:start . 236) (:id . 76))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 254)\n  (:start . 248) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1175.2) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010928@unknown@formal@none@1@S@One site is similar to activated TNFRII in associating with TNFR-associated factors TRAF1 and TRAF2, and the second site is similar to TNFRI in associating with the TNFRI death domain interacting protein TRADD.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "TNFRII") (:form . "TNFRII") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "associate") (:form . "associating") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "tnfr-associated") (:form . "TNFR-associated")\n  (:end . 75) (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "TRAF1") (:form . "TRAF1") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TRAF2") (:form . "TRAF2") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "associate") (:form . "associating") (:end . 155)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 183)\n  (:start . 177) (:id . 72))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 195)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 203)\n  (:start . 196) (:id . 74))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 209)\n  (:start . 204) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1175.3) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010930@unknown@formal@none@1@S@IkappaB alpha phosphorylation on Ser-32 and Ser-36 is followed by its degradation and NF-kappaB activation.@(((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser-32") (:form . "Ser-32") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser-36") (:form . "Ser-36") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1175.5) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010931@unknown@formal@none@1@S@In this report, we show that NF-kappaB activation by LMP1 or by each of its effector sites is mediated by a pathway that includes NIK, IKKalpha, and IKKbeta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 84)\n  (:start . 76) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 115)\n  (:start . 108) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 133) (:start . 130)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 143)\n  (:start . 135) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 156)\n  (:start . 149) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1175.6) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010932@unknown@formal@none@1@S@Dominant negative mutants of NIK, IKKalpha, or IKKbeta substantially inhibited NF-kappaB activation by LMP1 or by each of its effector sites.@(((:tag . "JJ") (:stem . "dominant") (:form . "Dominant") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 68) (:start . 55) (:id . 52))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1175.7) (:did . :|9707608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010933@unknown@formal@none@1@S@Dimethyldithiocarbamate inhibits in vitro activation of primary human CD4+ T lymphocytes.@(((:tag . "NNP") (:stem . "Dimethyldithiocarbamate")\n  (:form . "Dimethyldithiocarbamate") (:end . 23) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 32)\n  (:start . 24) (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 41) (:start . 36)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 52)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 63)\n  (:start . 56) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 88)\n  (:start . 77) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1176.1) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010934@unknown@formal@none@1@S@Dithiocarbamates (DTC), a diverse group of industrial and therapeutic chemicals, have been reported to inhibit, enhance or have no effect on the immune system.@(((:tag . "NNP") (:stem . "Dithiocarbamate") (:form . "Dithiocarbamates")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "DTC") (:form . "DTC") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "industrial") (:form . "industrial") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "chemical") (:form . "chemicals") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 137)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 151)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 158)\n  (:start . 152) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x1176.2.1) (:span 128 130)))\n (:nscopes ((:id . :x1176.2.1) (:span 128 158)))\n (:identifiers (:sid . :s1176.2) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010935@unknown@formal@none@1@S@These apparent inconsistencies reflect the complexity of the DTCs biological activities and are probably due in part to differences in dose, route of exposure, animal species used and/or specific compound tested.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "inconsistency") (:form . "inconsistencies")\n  (:end . 30) (:start . 15) (:id . 44))\n ((:tag . "VBP") (:stem . "reflect") (:form . "reflect") (:end . 38)\n  (:start . 31) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "complexity") (:form . "complexity") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DTC") (:form . "DTCs") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 131)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "route") (:form . "route") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 158)\n  (:start . 150) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 174)\n  (:start . 167) (:id . 69))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 186)\n  (:start . 180) (:id . 71))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 195)\n  (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 204)\n  (:start . 196) (:id . 73))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 211)\n  (:start . 205) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1176.3.1) (:span 96 104)))\n (:hscopes ((:id . :x1176.3.1) (:span 96 211)))\n (:identifiers (:sid . :s1176.3) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010936@unknown@formal@none@1@S@The studies described herein were undertaken to investigate the immunotoxicity of one member of this family, dimethyldithiocarbamate (DMDTC).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "herein") (:form . "herein") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "undertake") (:form . "undertaken") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunotoxicity") (:form . "immunotoxicity")\n  (:end . 78) (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dimethyldithiocarbamate")\n  (:form . "dimethyldithiocarbamate") (:end . 132) (:start . 109) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DMDTC") (:form . "DMDTC") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1176.4) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010937@unknown@formal@none@1@S@We demonstrate that 0.1-0.5 microM DMDTC inhibits TNF-alpha-induced activation of NF-kappaB in primary human CD4+ T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "0.1-0.5") (:form . "0.1-0.5") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "DMDTC") (:form . "DMDTC") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "tnf-alpha-induced") (:form . "TNF-alpha-induced")\n  (:end . 67) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 78)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 91)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 102)\n  (:start . 95) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 108)\n  (:start . 103) (:id . 55))\n ((:tag . "JJ") (:stem . "cd4+") (:form . "CD4+") (:end . 113) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1176.5) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010938@unknown@formal@none@1@S@This inhibition is not accompanied by a loss in viability, and DMDTC-treated T cells retain other active signaling pathways throughout the exposure duration.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "viability") (:form . "viability") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dmdtc-treated") (:form . "DMDTC-treated")\n  (:end . 76) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "retain") (:form . "retain") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "duration") (:form . "duration") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1176.6.1) (:span 19 22)))\n (:nscopes ((:id . :x1176.6.1) (:span 0 57)))\n (:identifiers (:sid . :s1176.6) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010940@unknown@formal@none@1@S@DMDTC does not appear to alter NF-kappaB directly as pre-incubation of nuclear extracts with DMDTC does not diminish binding activity of this protein.@(((:tag . "NNP") (:stem . "DMDTC") (:form . "DMDTC") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VB") (:stem . "alter") (:form . "alter") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pre-incubation") (:form . "pre-incubation")\n  (:end . 67) (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DMDTC") (:form . "DMDTC") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "VB") (:stem . "diminish") (:form . "diminish") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1176.8.3) (:span 15 21)))\n (:ncues ((:id . :x1176.8.1) (:span 104 107))\n  ((:id . :x1176.8.2) (:span 11 14)))\n (:hscopes ((:id . :x1176.8.3) (:span 0 49)))\n (:nscopes ((:id . :x1176.8.1) (:span 104 149))\n  ((:id . :x1176.8.2) (:span 0 49)))\n (:identifiers (:sid . :s1176.8) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010941@unknown@formal@none@1@S@We further demonstrate that 0.1-0.5 microM DMDTC inhibits intracellular IL-2 production and decreases surface expression of CD25 (the alpha subunit of the IL-2 receptor) in T cells stimulated with phorbol ester.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "CD") (:stem . "0.1-0.5") (:form . "0.1-0.5") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "microM") (:form . "microM") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "DMDTC") (:form . "DMDTC") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 71) (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 101)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 109)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd25") (:form . "CD25") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 147)\n  (:start . 140) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 180)\n  (:start . 175) (:id . 70))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 191)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 204)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "ester") (:form . "ester") (:end . 210)\n  (:start . 205) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1176.9) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010942@unknown@formal@none@1@S@These data demonstrate that DMDTC is a potent immunosuppressive compound in vitro.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DMDTC") (:form . "DMDTC") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 63) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1176.10) (:did . :|9710149|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010943@unknown@formal@none@1@S@The small GTP-binding protein Rho potentiates AP-1 transcription in T cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "gtp-binding") (:form . "GTP-binding") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNP") (:stem . "Rho") (:form . "Rho") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1177.1) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010944@unknown@formal@none@1@S@The Rho family of small GTP-binding proteins is involved in the regulation of cytoskeletal structure, gene transcription, specific cell fate development, and transformation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Rho") (:form . "Rho") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "gtp-binding") (:form . "GTP-binding") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytoskeletal") (:form . "cytoskeletal") (:end . 90)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 120) (:start . 107) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "fate") (:form . "fate") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 172) (:start . 158) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1177.2) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010945@unknown@formal@none@1@S@We demonstrate in this report that overexpression of an activated form of Rho enhances AP-1 activity in Jurkat T cells in the presence of phorbol myristate acetate (PMA), but activated Rho (V14Rho) has little or no effect on NFAT, Oct-1, and NF-kappaB enhancer element activities under similar conditions.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "overexpression") (:form . 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"and") (:end . 241) (:start . 238)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 251)\n  (:start . 242) (:id . 90))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 260)\n  (:start . 252) (:id . 91))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 268)\n  (:start . 261) (:id . 92))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 279)\n  (:start . 269) (:id . 93))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 285)\n  (:start . 280) (:id . 94))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 293)\n  (:start . 286) (:id . 95))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 304)\n  (:start . 294) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5010946@unknown@formal@none@1@S@Overexpression of a V14Rho construct incapable of membrane localization (CAAX deleted) abolishes PMA-induced AP-1 transcriptional activation.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "V14Rho") (:form . "V14Rho") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "incapable") (:form . "incapable") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CAAX") (:form . "CAAX") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "abolish") (:form . "abolishes") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "pma-induced") (:form . "PMA-induced") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 129) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 140)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1177.4) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010947@unknown@formal@none@1@S@The effect of Rho on AP-1 is independent of the mitogen-activated protein kinase pathway, as a dominant-negative MEK and a MEK inhibitor (PD98059) did not affect Rho-induced AP-1 activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Rho") (:form . "Rho") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 40)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 65) (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 112) (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "mek") (:form . "MEK") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MEK") (:form . "MEK") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PD98059") (:form . "PD98059") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 161)\n  (:start . 155) (:id . 70))\n ((:tag . "JJ") (:stem . "rho-induced") (:form . "Rho-induced") (:end . 173)\n  (:start . 162) (:id . 71))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 178) (:start . 174)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 187)\n  (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1177.5.1) (:span 151 154)))\n (:nscopes ((:id . :x1177.5.1) (:span 151 187)))\n (:identifiers (:sid . :s1177.5) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010948@unknown@formal@none@1@S@V14Rho binds strongly to protein kinase Calpha (PKCalpha) in vivo; however, deletion of the CAAX site on V14Rho severely diminished this association.@(((:tag . "NNP") (:stem . "V14Rho") (:form . "V14Rho") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "Calpha") (:form . "Calpha") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PKCalpha") (:form . "PKCalpha") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CAAX") (:form . "CAAX") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "V14Rho") (:form . "V14Rho") (:end . 111)\n  (:start . 105) (:id . 63))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 120)\n  (:start . 112) (:id . 64))\n ((:tag . "VBD") (:stem . "diminish") (:form . "diminished") (:end . 131)\n  (:start . 121) (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 148)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1177.6) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010950@unknown@formal@none@1@S@These data suggest that Rho potentiates AP-1 transcription during T-cell activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rho") (:form . "Rho") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x1177.8.1) (:span 11 18)))\n (:hscopes ((:id . :x1177.8.1) (:span 11 83)))\n (:identifiers (:sid . :s1177.8) (:did . :|9710582|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010951@unknown@formal@none@1@S@Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tax") (:form . "Tax") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1178.1) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010952@unknown@formal@none@1@S@Tax corresponds to a 40-kDa transforming protein from the pathogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) that activates nuclear expression of the NF-kappaB/Rel family of transcription factors by an unknown mechanism.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "40-kda") (:form . "40-kDa") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "retrovirus") (:form . "retrovirus") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 107)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 157)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 178) (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 185)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 202) (:start . 189) (:id . 71))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 210)\n  (:start . 203) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 213) (:start . 211)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 216) (:start . 214)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 224)\n  (:start . 217) (:id . 75))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 234)\n  (:start . 225) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1178.2.1) (:span 217 224)))\n (:hscopes ((:id . :x1178.2.1) (:span 217 234)))\n (:identifiers (:sid . :s1178.2) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010953@unknown@formal@none@1@S@Tax expression promotes N-terminal phosphorylation and degradation of IkappaB alpha, a principal cytoplasmic inhibitor of NF-kappaB.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 50) (:start . 35) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 66)\n  (:start . 55) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 77)\n  (:start . 70) (:id . 50))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 83) (:start . 78)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "principal") (:form . "principal") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 108)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 118)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 131)\n  (:start . 122) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1178.3) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010954@unknown@formal@none@1@S@Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in response to tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) stimulation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . 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5010955@unknown@formal@none@1@S@In contrast, a mutant of Tax termed M22, which does not induce NF-kappaB, fails to activate either IKKalpha or IKKbeta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 21)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 35) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "m22") (:form . "M22") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 46) (:start . 41)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 51) (:start . 47)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 62)\n  (:start . 56) (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 72)\n  (:start . 63) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 79) (:start . 74)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 91)\n  (:start . 83) (:id . 60))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 98)\n  (:start . 92) (:id . 61))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 107)\n  (:start . 99) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 118)\n  (:start . 111) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1178.5.1) (:span 74 79))\n  ((:id . :x1178.5.2) (:span 52 55)))\n (:nscopes ((:id . :x1178.5.1) (:span 74 118))\n  ((:id . :x1178.5.2) (:span 52 72)))\n (:identifiers (:sid . :s1178.5) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010956@unknown@formal@none@1@S@Furthermore, endogenous IKK enzymatic activity was significantly elevated in HTLV-1-infected and Tax-expressing T-cell lines.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "htlv-1-infected") (:form . "HTLV-1-infected")\n  (:end . 92) (:start . 77) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "tax-expressing") (:form . "Tax-expressing")\n  (:end . 111) (:start . 97) (:id . 54))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 118)\n  (:start . 112) (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 124)\n  (:start . 119) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1178.6) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010957@unknown@formal@none@1@S@Transfection of kinase-deficient mutants of IKKalpha and IKKbeta into either human Jurkat T or 293 cells also inhibits NF-kappaB-dependent reporter gene expression induced by Tax.@(((:tag . "NN") (:stem . "transfection") (:form . "Transfection") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "kinase-deficient") (:form . "kinase-deficient")\n  (:end . 32) (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "CD") (:stem . "293") (:form . "293") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 138) (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 147)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 63))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 171)\n  (:start . 164) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 178) (:start . 175)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1178.7) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010958@unknown@formal@none@1@S@Similarly, a kinase-deficient mutant of NIK (NF-kappaB-inducing kinase), which represents an upstream kinase in the TNF-alpha and IL-1 signaling pathways leading to IKKalpha and IKKbeta activation, blocks Tax induction of NF-kappaB.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "kinase-deficient") (:form . "kinase-deficient")\n  (:end . 29) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NIK") (:form . "NIK") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB-inducing") (:form . "NF-kappaB-inducing")\n  (:end . 63) (:start . 45) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "kinase") (:form . "kinase") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IKKalpha") (:form . "IKKalpha") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IKKbeta") (:form . "IKKbeta") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 196)\n  (:start . 186) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 204)\n  (:start . 198) (:id . 73))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 218)\n  (:start . 209) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 231)\n  (:start . 222) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1178.8) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010960@unknown@formal@none@1@S@Together, these studies demonstrate that HTLV-1 Tax exploits a distal part of the proinflammatory cytokine signaling cascade leading to induction of NF-kappaB.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "exploit") (:form . "exploits") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distal") (:form . "distal") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 97) (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 145)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 158)\n  (:start . 149) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1178.10) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010961@unknown@formal@none@1@S@The pathological alteration of this cytokine pathway leading to NF-kappaB activation by Tax may play a central role in HTLV-1-mediated transformation of human T cells, clinically manifested as the adult T-cell leukemia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "pathological") (:form . "pathological") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "htlv-1-mediated") (:form . "HTLV-1-mediated")\n  (:end . 134) (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 149) (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 158)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 160) (:start . 159)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 67))\n ((:tag . "RB") (:stem . "clinically") (:form . "clinically") (:end . 178)\n  (:start . 168) (:id . 68))\n ((:tag . "VBN") (:stem . "manifest") (:form . "manifested") (:end . 189)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 202)\n  (:start . 197) (:id . 72))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 209)\n  (:start . 203) (:id . 73))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 218)\n  (:start . 210) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1178.11.1) (:span 92 95)))\n (:hscopes ((:id . :x1178.11.1) (:span 92 218)))\n (:identifiers (:sid . :s1178.11) (:did . :|9710600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010962@unknown@formal@none@1@S@A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cd28-associated") (:form . "CD28-associated")\n  (:end . 17) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 74) (:start . 61) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 99) (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1179.1.1) (:span 100 107)))\n (:nscopes ((:id . :x1179.1.1) (:span 100 122)))\n (:identifiers (:sid . :s1179.1) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010963@unknown@formal@none@1@S@Stimulation of resting human T cells with the CD28-specific mAb BW 828 induces proliferation and cytokine synthesis without further requirement for TCR coengagement.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd28-specific") (:form . "CD28-specific")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BW") (:form . "BW") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "CD") (:stem . "828") (:form . "828") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 143)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "NN") (:stem . "coengagement") (:form . "coengagement") (:end . 164)\n  (:start . 152) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1179.2.1) (:span 116 123)))\n (:nscopes ((:id . :x1179.2.1) (:span 116 164)))\n (:identifiers (:sid . :s1179.2) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010964@unknown@formal@none@1@S@This observation prompted us to postulate that signal 2 (costimulatory signal) alone without signal 1 (TCR signal) can activate T cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "prompt") (:form . "prompted") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "postulate") (:form . "postulate") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 127)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1179.3.1) (:span 85 92)))\n (:nscopes ((:id . :x1179.3.1) (:span 85 114)))\n (:identifiers (:sid . :s1179.3) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010965@unknown@formal@none@1@S@To test whether this putative function of CD28 is mediated via a particular signaling pathway, we compared early signaling events initiated in resting T cells by the stimulatory mAb BW 828 with signals triggered by the nonstimulating CD28 mAb 9.3.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 93)\n  (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 177)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 181) (:start . 178)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "BW") (:form . "BW") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "CD") (:stem . "828") (:form . "828") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 201)\n  (:start . 194) (:id . 75))\n ((:tag . "VBN") (:stem . "trigger") (:form . "triggered") (:end . 211)\n  (:start . 202) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nonstimulating") (:form . "nonstimulating")\n  (:end . 233) (:start . 219) (:id . 79))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 238) (:start . 234)\n  (:id . 80))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 242) (:start . 239)\n  (:id . 81))\n ((:tag . "CD") (:stem . "9.3") (:form . "9.3") (:end . 246) (:start . 243)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1179.4.1) (:span 21 29)) ((:id . :x1179.4.2) (:span 8 15)))\n (:hscopes ((:id . :x1179.4.1) (:span 21 46))\n  ((:id . :x1179.4.2) (:span 8 93)))\n (:identifiers (:sid . :s1179.4) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010966@unknown@formal@none@1@S@Stimulation of T cells with BW 828 induced an increase in intracellular Ca2+, but did not lead to detectable activation of the protein kinases p56(lck) and c-Raf-1.@(((:tag . "NN") (:stem . "stimulation") (:form . "Stimulation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BW") (:form . "BW") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "828") (:form . "828") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 108)\n  (:start . 98) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "JJ") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "c-raf-1") (:form . "c-Raf-1") (:end . 163)\n  (:start . 156) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1179.5.1) (:span 86 89)))\n (:nscopes ((:id . :x1179.5.1) (:span 86 163)))\n (:identifiers (:sid . :s1179.5) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010967@unknown@formal@none@1@S@This pathway resulted in the induction of the transcription factors NF-kappa B, NF-AT, and proteins binding to the CD28 response element of the IL-2 promoter.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 59) (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1179.6) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010968@unknown@formal@none@1@S@On the other hand, stimulation of T cells with mAb 9.3 increased the level of intracellular Ca2+ and triggered the activation of p56(lck) and c-Raf-1, but was unable to induce the binding of transcription factors to the IL-2 promoter.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "CD") (:stem . "9.3") (:form . "9.3") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 64)\n  (:start . 55) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 91) (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "trigger") (:form . "triggered") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "CD") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-raf-1") (:form . "c-Raf-1") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 72))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 175)\n  (:start . 169) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 204) (:start . 191) (:id . 77))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 212)\n  (:start . 205) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 215) (:start . 213)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 224) (:start . 220)\n  (:id . 81))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 233)\n  (:start . 225) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x1179.7.1) (:span 159 165)))\n (:nscopes ((:id . :x1179.7.1) (:span 155 233)))\n (:identifiers (:sid . :s1179.7) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010970@unknown@formal@none@1@S@These data support the view that stimulation through CD28 can induce some effector functions in T cells and suggest that this capacity is associated with a particular pattern of early signaling events.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "view") (:form . "view") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 44)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 148)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 166)\n  (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 174)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 193)\n  (:start . 184) (:id . 72))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 200)\n  (:start . 194) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1179.9.1) (:span 108 115)))\n (:hscopes ((:id . :x1179.9.1) (:span 108 200)))\n (:identifiers (:sid . :s1179.9) (:did . :|9712026|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010971@unknown@formal@none@1@S@Cyclosporin A-resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive serine/threonine phosphatases.@(((:tag . "NNP") (:stem . "Cyclosporin") (:form . "Cyclosporin") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "a-resistant") (:form . "A-resistant") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 39) (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 69)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 78)\n  (:start . 70) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . "JJ") (:stem . "acid-sensitive") (:form . "acid-sensitive")\n  (:end . 104) (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 121) (:start . 105) (:id . 54))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 134)\n  (:start . 122) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1180.1) (:did . :|9712047|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010972@unknown@formal@none@1@S@Expression of the IL-2 gene requires activation of T cells through stimulation of the TCR and costimulation through accessory receptors.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 78)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 107) (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "accessory") (:form . "accessory") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1180.2) (:did . :|9712047|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010973@unknown@formal@none@1@S@We have found recently that okadaic acid-sensitive Ser/Thr phosphatases are involved in a cyclosporin A-insensitive pathway that selectively transmits costimulatory signals.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "acid-sensitive") (:form . "acid-sensitive")\n  (:end . 50) (:start . 36) (:id . 48))\n ((:tag . "NNP") (:stem . "Ser/Thr") (:form . "Ser/Thr") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "JJ") (:stem . "a-insensitive") (:form . "A-insensitive")\n  (:end . 115) (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 123)\n  (:start . 116) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 140)\n  (:start . 129) (:id . 59))\n ((:tag . "VBZ") (:stem . "transmit") (:form . "transmits") (:end . 150)\n  (:start . 141) (:id . 60))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 164) (:start . 151) (:id . 61))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 172)\n  (:start . 165) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1180.3) (:did . :|9712047|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010974@unknown@formal@none@1@S@In this study, we analyzed whether activities of these phosphatases are necessary for the expression of the IL-2 gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1180.4.1) (:span 27 34)))\n (:hscopes ((:id . :x1180.4.1) (:span 27 117)))\n (:identifiers (:sid . :s1180.4) (:did . :|9712047|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010975@unknown@formal@none@1@S@In both activated peripheral blood T lymphocytes and activated tumorigenic T cell lines, IL-2 gene expression was blocked at the transcriptional level by okadaic acid.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "tumorigenic") (:form . "tumorigenic") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 144) (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 150)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 161)\n  (:start . 154) (:id . 66))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1180.5) (:did . :|9712047|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010976@unknown@formal@none@1@S@The transcription factors active at the IL-2 promoter were differentially influenced: upon down-modulation of okadaic acid-sensitive phosphatases, transactivation by octamer, NF-kappa B, and NF of activated T cells proteins was abrogated, while transactivation by AP-1 proteins was even enhanced.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 73) (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "down-modulation") (:form . "down-modulation")\n  (:end . 106) (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "okadaic") (:form . "okadaic") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . "JJ") (:stem . "acid-sensitive") (:form . "acid-sensitive")\n  (:end . 132) (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "phosphatas") (:form . "phosphatases") (:end . 145)\n  (:start . 133) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 162) (:start . 147) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 62))\n ((:tag . "NN") (:stem . "octamer") (:form . "octamer") (:end . 173)\n  (:start . 166) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 183)\n  (:start . 175) (:id . 65))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF") (:form . "NF") (:end . 193) (:start . 191)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 206)\n  (:start . 197) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 208) (:start . 207)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 223)\n  (:start . 215) (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 227) (:start . 224)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 237)\n  (:start . 228) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 77))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 244)\n  (:start . 239) (:id . 78))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 260) (:start . 245) (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 263) (:start . 261)\n  (:id . 80))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 268) (:start . 264)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 277)\n  (:start . 269) (:id . 82))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 281) (:start . 278)\n  (:id . 83))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 286) (:start . 282)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 295)\n  (:start . 287) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1180.6) (:did . :|9712047|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010977@unknown@formal@none@1@S@Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.@(((:tag . "JJ") (:stem . "inducible") (:form . "Inducible") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 41) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "feedback") (:form . "feedback") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 85)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1181.1) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010978@unknown@formal@none@1@S@Inducible nitric oxide (iNO) is produced at sites of vascular inflammation by resident and nonresident vascular wall cells, but its role in the inflammatory process is not known.@(((:tag . "JJ") (:stem . "inducible") (:form . "Inducible") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "nitric") (:form . "nitric") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 74)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "resident") (:form . "resident") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonresident") (:form . "nonresident") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "wall") (:form . "wall") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 156)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 164)\n  (:start . 157) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 171) (:start . 168)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 177)\n  (:start . 172) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1181.2.1) (:span 168 177)))\n (:hscopes ((:id . :x1181.2.1) (:span 128 177)))\n (:identifiers (:sid . :s1181.2) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010980@unknown@formal@none@1@S@We find that iNO produced by murine macrophage-like cells, RAW264.7, can inhibit cytokine-induced endothelial cell activation in a separated and mixed endothelial-RAW264.7 coculture system.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 51) (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "raw264.7") (:form . "RAW264.7") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "JJ") (:stem . "cytokine-induced") (:form . "cytokine-induced")\n  (:end . 97) (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 125)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "mix") (:form . "mixed") (:end . 150) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "endothelial-raw264.7")\n  (:form . "endothelial-RAW264.7") (:end . 171) (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "coculture") (:form . "coculture") (:end . 181)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 188)\n  (:start . 182) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1181.4) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010981@unknown@formal@none@1@S@Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 81) (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "murine-specific") (:form . "murine-specific")\n  (:end . 120) (:start . 105) (:id . 56))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 130)\n  (:start . 121) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1181.5) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010982@unknown@formal@none@1@S@Inhibition of iNO synthase (iNOS) activity with N omega-monomethyl-L-arginine in endothelial-RAW264.7 cocultures, stimulated with murine-specific IFN-gamma and LPS, decreased iNO production by 86%, augmented VCAM-1 and iNOS expression in endothelial and RAW264.7 cells, respectively, and increased monocyte adhesion to the endothelial cell surface.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . 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5010983@unknown@formal@none@1@S@Transient transfection studies using various VCAM-1 promoter constructs demonstrated that inhibitory effects of iNO on VCAM-1 gene transcription were mediated, in part, by inhibitory effects of iNO on kappa B cis-acting elements.@(((:tag . "JJ") (:stem . "transient") (:form . "Transient") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 71)\n  (:start . 61) (:id . 49))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 84)\n  (:start . 72) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 100)\n  (:start . 90) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 108)\n  (:start . 101) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 115) (:start . 112)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 118) (:start . 116)\n  (:id . 56))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 144) (:start . 131) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 149) (:start . 145)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 158)\n  (:start . 150) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 63))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 167) (:start . 163)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 182)\n  (:start . 172) (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 190)\n  (:start . 183) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 206)\n  (:start . 201) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 208) (:start . 207)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 219)\n  (:start . 209) (:id . 74))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 228)\n  (:start . 220) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1181.7) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010984@unknown@formal@none@1@S@Immunofluorescence studies using an Ab to the RelA (p65) subunit of nuclear factor-kappa B revealed that iNO inhibited the activation of nuclear factor-kappa B.@(((:tag . "NNP") (:stem . "Immunofluorescence") (:form . "Immunofluorescence")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 43))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 32) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ab") (:form . "Ab") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RelA") (:form . "RelA") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 88)\n  (:start . 76) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 157)\n  (:start . 145) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1181.8) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010985@unknown@formal@none@1@S@These studies indicate that iNO attenuates iNOS expression in macrophages and inhibits monocyte adhesion to endothelial cells, and suggest that endogenously derived iNO may be an important autoregulatory inhibitor of vascular inflammation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "attenuate") (:form . "attenuates") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "inos") (:form . "iNOS") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 119)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 138)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "RB") (:stem . "endogenously") (:form . "endogenously") (:end . 156)\n  (:start . 144) (:id . 63))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "ino") (:form . "iNO") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 175) (:start . 173)\n  (:id . 67))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "JJ") (:stem . "autoregulatory") (:form . "autoregulatory")\n  (:end . 203) (:start . 189) (:id . 70))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 213)\n  (:start . 204) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 225)\n  (:start . 217) (:id . 73))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 238)\n  (:start . 226) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1181.9.1) (:span 169 172))\n  ((:id . :x1181.9.2) (:span 131 138)) ((:id . :x1181.9.3) (:span 14 27)))\n (:hscopes ((:id . :x1181.9.1) (:span 169 238))\n  ((:id . :x1181.9.2) (:span 131 238)) ((:id . :x1181.9.3) (:span 14 125)))\n (:identifiers (:sid . :s1181.9) (:did . :|9712068|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010986@unknown@formal@none@1@S@Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 41)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 69)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1182.1) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010987@unknown@formal@none@1@S@Cytokines, IL-2, IL-4, IL-6, IL-7, IL-12, and IL-15 are key regulators of human peripheral blood T and NK cell activation and differentiation but the precise mechanisms that give rise to their differential activities within these cells are not clear.@(((:tag . "NNP") (:stem . "Cytokine") (:form . "Cytokines") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 33) (:start . 29)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 40) (:start . 35)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-15") (:form . "IL-15") (:end . 51) (:start . 46)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 59) (:start . 56)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 70)\n  (:start . 60) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 90)\n  (:start . 80) (:id . 61))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 96) (:start . 91)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 98) (:start . 97)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 64))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 105) (:start . 103)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 110) (:start . 106)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 68))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 141) (:start . 126) (:id . 69))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 145) (:start . 142)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 157)\n  (:start . 150) (:id . 72))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 168)\n  (:start . 158) (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 173) (:start . 169)\n  (:id . 74))\n ((:tag . "VBP") (:stem . "give") (:form . "give") (:end . 178) (:start . 174)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 183) (:start . 179)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 186) (:start . 184)\n  (:id . 77))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 192)\n  (:start . 187) (:id . 78))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 205)\n  (:start . 193) (:id . 79))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 216)\n  (:start . 206) (:id . 80))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 223)\n  (:start . 217) (:id . 81))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 229)\n  (:start . 224) (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 235)\n  (:start . 230) (:id . 83))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 239) (:start . 236)\n  (:id . 84))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 243) (:start . 240)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 249)\n  (:start . 244) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x1182.2.1) (:span 240 249)))\n (:hscopes ((:id . :x1182.2.1) (:span 146 249)))\n (:identifiers (:sid . :s1182.2) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010988@unknown@formal@none@1@S@Recent studies reveal that a family of transcription factors, signal transducers and activators of transcription (STATs) directly mediate many cytokine signals.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 80)\n  (:start . 69) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 159)\n  (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1182.3) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010990@unknown@formal@none@1@S@We demonstrate that IL-12 induces STAT4 only in freshly isolated primary NK cells, but not in primary T cells, consistent with the lack of the IL-12 receptor in resting T cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "stat4") (:form . "STAT4") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 121)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 148)\n  (:start . 143) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 157)\n  (:start . 149) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "rest") (:form . "resting") (:end . 168)\n  (:start . 161) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 170) (:start . 169)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 176)\n  (:start . 171) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x1182.5.1) (:span 131 135))\n  ((:id . :x1182.5.2) (:span 87 90)))\n (:nscopes ((:id . :x1182.5.1) (:span 131 176))\n  ((:id . :x1182.5.2) (:span 87 109)))\n (:identifiers (:sid . :s1182.5) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010991@unknown@formal@none@1@S@In contrast, IL-4 induces different C epsilon GAS DNA-protein binding complexes in both T and NK cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1182.6) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010992@unknown@formal@none@1@S@Moreover, IL-4 costimulation with IL-2 or IL-12 does not alter their own preferential GAS-like DNA binding patterns when C epsilon-, Fc gamma RI-, and SIE GAS motif containing oligonucleotide probes are compared, suggesting that induction of GAS-like DNA-protein binding complexes by IL-2, IL-4, and IL-12 is highly selective and represents one important factor in determining specific gene activation.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "costimulation") (:form . "costimulation")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . 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"one") (:end . 344) (:start . 341)\n  (:id . 98))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 354)\n  (:start . 345) (:id . 99))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 361)\n  (:start . 355) (:id . 100))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 364) (:start . 362)\n  (:id . 101))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 376)\n  (:start . 365) (:id . 102))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 385)\n  (:start . 377) (:id . 103))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 390) (:start . 386)\n  (:id . 104))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 401)\n  (:start . 391) (:id . 105))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5010993@unknown@formal@none@1@S@In addition, IL-6 and IL-2 synergistically induce homo- and heterodimerized STAT1 alpha and STAT3 in both NK and T cells, consistent with their reported synergism in modulating perforin gene expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 42) (:start . 27) (:id . 48))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "homo-") (:form . "homo-") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "heterodimerized") (:form . "heterodimerized")\n  (:end . 75) (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "synergism") (:form . "synergism") (:end . 162)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "perforin") (:form . "perforin") (:end . 185)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 201)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1182.8) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010994@unknown@formal@none@1@S@We further demonstrated that IL-2, -7, and -15 induce multiple STAT proteins, including STAT5a, STAT5b, STAT1 alpha, STAT3, and another unidentified Fc gamma RI GAS DNA-binding protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-7") (:form . "-7") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "CD") (:stem . "-15") (:form . "-15") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "stat") (:form . "STAT") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "NNP") (:stem . "STAT5a") (:form . "STAT5a") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "STAT5b") (:form . "STAT5b") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "STAT3") (:form . "STAT3") (:end . 122)\n  (:start . 117) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 67))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 135)\n  (:start . 128) (:id . 68))\n ((:tag . "JJ") (:stem . "unidentified") (:form . "unidentified") (:end . 148)\n  (:start . 136) (:id . 69))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 157)\n  (:start . 152) (:id . 71))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 160) (:start . 158)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 164) (:start . 161)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 176)\n  (:start . 165) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 184)\n  (:start . 177) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1182.9) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010995@unknown@formal@none@1@S@Finally, we observed that activated STAT5a and STAT5b proteins form distinct Fc gamma RI GAS binding patterns in T and NK cells, suggesting that they might have different roles in gene regulation.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNP") (:stem . "STAT5a") (:form . "STAT5a") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "STAT5b") (:form . "STAT5b") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "Fc") (:form . "Fc") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RI") (:form . "RI") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 139)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 170)\n  (:start . 161) (:id . 71))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 184) (:start . 180)\n  (:id . 74))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 195)\n  (:start . 185) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1182.10.1) (:span 150 155))\n  ((:id . :x1182.10.2) (:span 129 139)))\n (:hscopes ((:id . :x1182.10.1) (:span 150 195))\n  ((:id . :x1182.10.2) (:span 129 195)))\n (:identifiers (:sid . :s1182.10) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010996@unknown@formal@none@1@S@Our data provide evidence that the differential responses in gene expression and cell activation seen in primary NK and T cells on direct stimulation with different cytokines may be a direct result of distinct activation of STAT transcription factors.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 101) (:start . 97)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 149)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 164)\n  (:start . 155) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 174)\n  (:start . 165) (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 190)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 197)\n  (:start . 191) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 209)\n  (:start . 201) (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 220)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 228) (:start . 224)\n  (:id . 78))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 242) (:start . 229) (:id . 79))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 250)\n  (:start . 243) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1182.11.1) (:span 175 178)))\n (:hscopes ((:id . :x1182.11.1) (:span 175 250)))\n (:identifiers (:sid . :s1182.11) (:did . :|9715265|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5010997@unknown@formal@none@1@S@Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AZT") (:form . "AZT") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1183.1) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5010998@unknown@formal@none@1@S@The small molecule S9a was derived from an established tumor necrosis factor-alpha (TNF-alpha) inhibitor (Canventol) by replacement of the isopropylidine group with a phenyl ring.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "S9a") (:form . "S9a") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Canventol") (:form . "Canventol") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "isopropylidine") (:form . "isopropylidine")\n  (:end . 153) (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "phenyl") (:form . "phenyl") (:end . 173)\n  (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1183.2) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011000@unknown@formal@none@1@S@Furthermore, S9a and AZT in combination, at noncytoxic concentrations strongly inhibited HIV-1 replication that was more than additive and substantially prolonged the appearance of virus both in acutely infected CD4+ lymphocytes (SupT) in culture and in peripheral blood mononuclear cells (PBMCs) infected with a primary HIV-1 isolate.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "S9a") (:form . "S9a") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "AZT") (:form . "AZT") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "combination") (:form . 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5011001@unknown@formal@none@1@S@S9a inhibited TNF-alpha promoter-driven reporter gene activity.@(((:tag . "NNP") (:stem . "S9a") (:form . "S9a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "promoter-driven") (:form . "promoter-driven")\n  (:end . 39) (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1183.5) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011002@unknown@formal@none@1@S@It was proposed that the mechanism of antiviral action of S9a was on the host cell, by blocking TNF-alpha transcription via a Tat-induced tar-independent loop, which decreases downstream NF-kappaB activation of HIV-1 long terminal repeat (LTR).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "S9a") (:form . "S9a") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 95)\n  (:start . 87) (:id . 60))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 105)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "tat-induced") (:form . "Tat-induced") (:end . 137)\n  (:start . 126) (:id . 65))\n ((:tag . "JJ") (:stem . "tar-independent") (:form . "tar-independent")\n  (:end . 153) (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "loop") (:form . "loop") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 175)\n  (:start . 166) (:id . 70))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 186)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 196)\n  (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 207)\n  (:start . 197) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 216)\n  (:start . 211) (:id . 75))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 221) (:start . 217)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 230)\n  (:start . 222) (:id . 77))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 237)\n  (:start . 231) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 239) (:start . 238)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 242) (:start . 239)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 243) (:start . 242)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1183.6.1) (:span 7 15)))\n (:hscopes ((:id . :x1183.6.1) (:span 7 243)))\n (:identifiers (:sid . :s1183.6) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011003@unknown@formal@none@1@S@S9a was superior to the first generation compound Canventol, which was superior to the natural compound sarcophytol A, demonstrating that further structure-based enhancement of potency of these compounds is feasible.@(((:tag . "NNP") (:stem . "S9a") (:form . "S9a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "superior") (:form . "superior") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NNP") (:stem . "Canventol") (:form . "Canventol") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "superior") (:form . "superior") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "sarcophytol") (:form . "sarcophytol") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 132) (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "JJ") (:stem . "structure-based") (:form . "structure-based")\n  (:end . 161) (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 173)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 193)\n  (:start . 188) (:id . 70))\n ((:tag . "NNS") (:stem . "compound") (:form . "compounds") (:end . 203)\n  (:start . 194) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 206) (:start . 204)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "feasible") (:form . "feasible") (:end . 215)\n  (:start . 207) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1183.7) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011004@unknown@formal@none@1@S@This study suggests a therapeutic approach against AIDS by application of two drugs, one against a cellular and the other a viral target, which may provide an approach to the problem of frequent emergence of resistant variants to combinations of drugs that target only HIV genes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . 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"cellular") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 167)\n  (:start . 159) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 73))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 182)\n  (:start . 175) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 194)\n  (:start . 186) (:id . 76))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 204)\n  (:start . 195) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 217)\n  (:start . 208) (:id . 79))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 226)\n  (:start . 218) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 229) (:start . 227)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 242)\n  (:start . 230) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "drug") (:form . "drugs") (:end . 251)\n  (:start . 246) (:id . 84))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 256) (:start . 252)\n  (:id . 85))\n ((:tag . "VBP") (:stem . "target") (:form . "target") (:end . 263)\n  (:start . 257) (:id . 86))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 268) (:start . 264)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 272) (:start . 269)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 278)\n  (:start . 273) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x1183.8.1) (:span 144 147))\n  ((:id . :x1183.8.2) (:span 11 19)))\n (:hscopes ((:id . :x1183.8.1) (:span 144 278))\n  ((:id . :x1183.8.2) (:span 11 136)))\n (:identifiers (:sid . :s1183.8) (:did . :|9715838|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011005@unknown@formal@none@1@S@Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro.@(((:tag . "JJ") (:stem . "retinoic") (:form . "Retinoic") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "interleukin-4-mediated")\n  (:form . "interleukin-4-mediated") (:end . 52) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1184.1) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011006@unknown@formal@none@1@S@To elucidate the role of retinoic acid (RA) in anti-CD40 + interleukin-4 (IL-4)-mediated B-cell activation, the effect of 10(-12) to 10(-6) mol/L RA was studied in anti-CD40 (1 microgram/mL) + IL-4 (5 ng/mL)-mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells (PBMC) and B cells in healthy donors.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 56)\n  (:start . 47) (:id . 53))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 72) (:start . 59) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-4)-mediated") (:form . "IL-4)-mediated")\n  (:end . 88) (:start . 74) (:id . 57))\n ((:tag . "NNP") (:stem . "B-cell") (:form . 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5011007@unknown@formal@none@1@S@Anti-CD40 + IL-4-mediated proliferation of PBMC and B cells was inhibited by RA in a dose-dependent manner, with maximal inhibition of 62% ± 5% in PBMC and 55% ± 4.4% in B cells by all-trans RA, and 58% ± 6.7% and 51% ± 4.7%, respectively by 13-cis RA.@(((:tag . "NNP") (:stem . "Anti-CD40") (:form . "Anti-CD40") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "il-4-mediated") (:form . "IL-4-mediated")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 39) (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . 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5011008@unknown@formal@none@1@S@IgE synthesis was even more markedly inhibited by RA starting at concentrations of >10(-14) mol/L for B cells and >10(-10) mol/L for PBMC.@(((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "start") (:form . "starting") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 79) (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . ">10(-14)") (:form . ">10(-14)") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNS") (:stem . ">10(-10)") (:form . ">10(-10)") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1184.4) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011010@unknown@formal@none@1@S@Low concentrations of RA inhibiting IgE synthesis (10(-10) mol/L) affected neither B-cell proliferation nor the production of IgA, IgG, and IgM.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "10(-10)") (:form . "10(-10)") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "mol/l") (:form . "mol/L") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "affect") (:form . "affected") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "b-cell") (:form . "B-cell") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 103) (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IgA") (:form . "IgA") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IgM") (:form . "IgM") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1184.6.1) (:span 75 82 104 107)))\n (:nscopes ((:id . :x1184.6.1) (:span 75 143)))\n (:identifiers (:sid . :s1184.6) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011011@unknown@formal@none@1@S@Elucidation of the mechanism involved in this inhibition of IgE production shows that epsilon germline transcription is decreased by RA, whereas production of interferon-gamma (IFN-gamma) was not enhanced in the presence of RA.@(((:tag . "NN") (:stem . "elucidation") (:form . "Elucidation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "epsilon") (:form . "epsilon") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 129)\n  (:start . 120) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 175) (:start . 159) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 186)\n  (:start . 177) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 195) (:start . 192)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 204)\n  (:start . 196) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 220)\n  (:start . 212) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x1184.7.1) (:span 192 195)))\n (:nscopes ((:id . :x1184.7.1) (:span 145 226)))\n (:identifiers (:sid . :s1184.7) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011012@unknown@formal@none@1@S@To differentiate whether the RA effect was mediated by RA receptors alpha, beta, and gamma, the expression of the retinoic acid receptors (RAR) was examined by reverse transcriptase-polymerase chain reaction (RT-PCR).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 106)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "retinoic") (:form . "retinoic") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 137)\n  (:start . 128) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 156)\n  (:start . 148) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 167)\n  (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "transcriptase-polymerase")\n  (:form . "transcriptase-polymerase") (:end . 192) (:start . 168) (:id . 74))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 198)\n  (:start . 193) (:id . 75))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 207)\n  (:start . 199) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 209) (:start . 208)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 215)\n  (:start . 209) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1184.8.1) (:span 17 24)))\n (:hscopes ((:id . :x1184.8.1) (:span 17 90)))\n (:identifiers (:sid . :s1184.8) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011013@unknown@formal@none@1@S@The data show that unstimulated human peripheral B cells express mRNA of the RA receptor alpha, beta, and gamma.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unstimulated") (:form . "unstimulated") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1184.9) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011014@unknown@formal@none@1@S@Using retinoids with different receptor binding specificity (CD336, CD437, CD2019, CD367), dose-dependent inhibition of IgE synthesis was shown by all four derivates, but was most marked by an RA binding the alpha receptor with high specificity.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "retinoid") (:form . "retinoids") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CD336") (:form . "CD336") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CD437") (:form . "CD437") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CD2019") (:form . "CD2019") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CD367") (:form . "CD367") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 105) (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IgE") (:form . "IgE") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "derivate") (:form . "derivates") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 179) (:start . 175)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 186)\n  (:start . 180) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 192) (:start . 190)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 195) (:start . 193)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 203)\n  (:start . 196) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 79))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 213)\n  (:start . 208) (:id . 80))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 222)\n  (:start . 214) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 227) (:start . 223)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 232) (:start . 228)\n  (:id . 83))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 244)\n  (:start . 233) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1184.10) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011015@unknown@formal@none@1@S@Taken together, this study shows that RA inhibits IgE production of anti-CD40 + IL-4-stimulated B cells in vitro.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-cd40") (:form . "anti-CD40") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "il-4-stimulated") (:form . "IL-4-stimulated")\n  (:end . 95) (:start . 80) (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1184.11) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011016@unknown@formal@none@1@S@Copyright 1998 by The American Society of Hematology.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "The") (:form . "The") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "American") (:form . "American") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "Society") (:form . "Society") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Hematology") (:form . "Hematology") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1184.12) (:did . :|9716600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011017@unknown@formal@none@1@S@Nuclear factor-kappaB induction in CD45RO+ and CD45RA+ T cell subsets during aging.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 31)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cd45ro+") (:form . "CD45RO+") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cd45ra+") (:form . "CD45RA+") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1185.1) (:did . :|9720648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011018@unknown@formal@none@1@S@An increase in the ratio of memory to naive T cells has been postulated to underlie immune hyporesponsiveness accompanying aging.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "postulate") (:form . "postulated") (:end . 71)\n  (:start . 61) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "hyporesponsiveness") (:form . "hyporesponsiveness")\n  (:end . 109) (:start . 91) (:id . 59))\n ((:tag . "VBG") (:stem . "accompany") (:form . "accompanying") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "aging") (:form . "aging") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1185.2) (:did . :|9720648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011020@unknown@formal@none@1@S@Although treatment with TNF-alpha induced nuclear localization of NFkappaB in both memory and naive T cell subsets, irrespective of the age of the donor, the levels of induced NFkappaB were significantly lower in both subsets of T cells obtained from the elderly, when compared to those in young.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "localization") (:form . 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5011021@unknown@formal@none@1@S@Examination of IkappaB alpha regulation revealed that TNF-alpha-mediated degradation of IkappaB alpha in both memory and naive T cells from the elderly was severely impaired, thus contributing to the lowered induction of the observed NFkappaB.@(((:tag . "NNP") (:stem . "Examination") (:form . "Examination") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tnf-alpha-mediated") (:form . "TNF-alpha-mediated")\n  (:end . 72) (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 84)\n  (:start . 73) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 95)\n  (:start . 88) (:id . 52))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 101) (:start . 96)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 109) (:start . 105)\n  (:id . 55))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 116)\n  (:start . 110) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 126)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 151)\n  (:start . 144) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 155) (:start . 152)\n  (:id . 64))\n ((:tag . "RB") (:stem . "severely") (:form . "severely") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 173)\n  (:start . 165) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 179) (:start . 175)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "contribute") (:form . "contributing") (:end . 192)\n  (:start . 180) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 195) (:start . 193)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "lowered") (:form . "lowered") (:end . 207)\n  (:start . 200) (:id . 72))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 217)\n  (:start . 208) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 233)\n  (:start . 225) (:id . 76))\n ((:tag . "NN") (:stem . "nfkappab") (:form . "NFkappaB") (:end . 242)\n  (:start . 234) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1185.5) (:did . :|9720648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011022@unknown@formal@none@1@S@In addition, this age-related decrease in induction of nuclear NFkappaB correlated with decrease in intracellular IL-2 receptor expression and anti-CD3-induced proliferation of both memory and naive T cells subsets.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "nfkappab") (:form . "NFkappaB") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 82)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 113) (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "anti-cd3-induced") (:form . "anti-CD3-induced")\n  (:end . 159) (:start . 143) (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 173) (:start . 160) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 181) (:start . 177)\n  (:id . 65))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 188)\n  (:start . 182) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 198)\n  (:start . 193) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 200) (:start . 199)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 206)\n  (:start . 201) (:id . 70))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 214)\n  (:start . 207) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1185.6) (:did . :|9720648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011023@unknown@formal@none@1@S@Taken together, our results suggest that the age-related hyporesponsiveness cannot be attributed to a skewing of the T cell population towards a memory phenotype in the elderly.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "age-related") (:form . "age-related") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "hyporesponsiveness") (:form . "hyporesponsiveness")\n  (:end . 75) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "skewing") (:form . "skewing") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "memory") (:form . "memory") (:end . 151)\n  (:start . 145) (:id . 65))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "elderly") (:form . "elderly") (:end . 176)\n  (:start . 169) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1185.7.2) (:span 28 35)))\n (:ncues ((:id . :x1185.7.1) (:span 76 82)))\n (:hscopes ((:id . :x1185.7.2) (:span 28 176)))\n (:nscopes ((:id . :x1185.7.1) (:span 41 176)))\n (:identifiers (:sid . :s1185.7) (:did . :|9720648|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011024@unknown@formal@none@1@S@Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "e2f-mediated") (:form . "E2F-mediated") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 49) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 71) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "p16(INK4A)-negative")\n  (:form . "p16(INK4A)-negative") (:end . 115) (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 127) (:start . 123)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1186.1) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011025@unknown@formal@none@1@S@The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "causative") (:form . "causative") (:end . 62)\n  (:start . 53) (:id . 54))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 84)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1186.2) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011026@unknown@formal@none@1@S@Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "leukemogenesis") (:form . "leukemogenesis")\n  (:end . 74) (:start . 60) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1186.3.1) (:span 112 119))\n  ((:id . :x1186.3.2) (:span 84 91)))\n (:hscopes ((:id . :x1186.3.1) (:span 93 156))\n  ((:id . :x1186.3.2) (:span 9 91)))\n (:identifiers (:sid . :s1186.3) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011027@unknown@formal@none@1@S@This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "40-kda") (:form . "40-kDa") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "suppressor") (:form . "suppressor") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "p16(INK4A)") (:form . "p16(INK4A)") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1186.4) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011028@unknown@formal@none@1@S@Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "E2F") (:form . "E2F") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "progression") (:form . "progression") (:end . 163)\n  (:start . 152) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1186.5) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011030@unknown@formal@none@1@S@Indeed, when Tax is coexpressed with the E2F-1 transcription factor in CEM T-cells, which lack expression of p16(INK4A), it strongly potentiates the E2F-dependent activation of a reporter construct driven by a promoter containing E2F binding sites.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "coexpresse") (:form . "coexpressed") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "e2f-1") (:form . "E2F-1") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 60) (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CEM") (:form . "CEM") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cells") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "p16(INK4A)") (:form . "p16(INK4A)") (:end . 119)\n  (:start . 109) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "VBZ") (:stem . "potentiate") (:form . "potentiates") (:end . 144)\n  (:start . 133) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "e2f-dependent") (:form . "E2F-dependent")\n  (:end . 162) (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 187)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 197)\n  (:start . 188) (:id . 72))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 204)\n  (:start . 198) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 75))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 229)\n  (:start . 219) (:id . 77))\n ((:tag . "NN") (:stem . "e2f") (:form . "E2F") (:end . 233) (:start . 230)\n  (:id . 78))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 241)\n  (:start . 234) (:id . 79))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 247)\n  (:start . 242) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1186.7.1) (:span 90 94)))\n (:nscopes ((:id . :x1186.7.1) (:span 90 119)))\n (:identifiers (:sid . :s1186.7) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011031@unknown@formal@none@1@S@This stimulation is abrogated by mutations affecting the E2F-binding sites.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "abrogate") (:form . "abrogated") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "e2f-binding") (:form . "E2F-binding") (:end . 68)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1186.8) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011032@unknown@formal@none@1@S@In addition, Tax also stimulates the transcription of the E2F-1 gene itself.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "stimulate") (:form . "stimulates") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "e2f-1") (:form . "E2F-1") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1186.9) (:did . :|9722600|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011033@unknown@formal@none@1@S@Using Tax mutants that fail to activate either ATF- or NF-kappaB-dependent promoters and different 5' truncation mutants of the E2F-1 promoter, we show that the Tax-dependent transcriptional control of the E2F1 gene involves, at least in part, the ATF binding site located in the E2F-1 promoter.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . 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5011034@unknown@formal@none@1@S@Glucocorticoid-induced apoptosis and regulation of NF-kappaB activity in human leukemic T cells.@(((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "Glucocorticoid-induced") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 32)\n  (:start . 23) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 47)\n  (:start . 37) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 60)\n  (:start . 51) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 69)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 95) (:start . 90)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1187.1) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011035@unknown@formal@none@1@S@Glucocorticoid-induced apoptosis was investigated in glucocorticoid-sensitive 6TG1.1 and resistant ICR27TK.3 human leukemic T cells.@(((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "Glucocorticoid-induced") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 32)\n  (:start . 23) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 49)\n  (:start . 37) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "glucocorticoid-sensitive")\n  (:form . "glucocorticoid-sensitive") (:end . 77) (:start . 53) (:id . 47))\n ((:tag . "NN") (:stem . "6tg1.1") (:form . "6TG1.1") (:end . 84)\n  (:start . 78) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 98)\n  (:start . 89) (:id . 50))\n ((:tag . "NN") (:stem . "icr27tk.3") (:form . "ICR27TK.3") (:end . 108)\n  (:start . 99) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 114)\n  (:start . 109) (:id . 52))\n ((:tag . "JJ") (:stem . "leukemic") (:form . "leukemic") (:end . 123)\n  (:start . 115) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 125) (:start . 124)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1187.2) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011036@unknown@formal@none@1@S@Following glucocorticoid treatment of 6TG1.1 cells, chromatin fragmentation was observed after a delay of 24 h.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 24) (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 34)\n  (:start . 25) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "NN") (:stem . "6tg1.1") (:form . "6TG1.1") (:end . 44)\n  (:start . 38) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 75) (:start . 62) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 54))\n ((:tag . "NN") (:stem . "delay") (:form . "delay") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1187.3) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011037@unknown@formal@none@1@S@Fragmentation was not observed in ICR27TK.3 cells containing mutant glucocorticoid receptors (L753F) that are activation-deficient but retain the ability to repress AP-1 activity.@(((:tag . "NN") (:stem . "fragmentation") (:form . "Fragmentation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "icr27tk.3") (:form . "ICR27TK.3") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 67)\n  (:start . 61) (:id . 50))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 82) (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 92)\n  (:start . 83) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "L753F") (:form . "L753F") (:end . 99) (:start . 94)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "activation-deficient")\n  (:form . "activation-deficient") (:end . 130) (:start . 110) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "retain") (:form . "retain") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 153)\n  (:start . 146) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "VB") (:stem . "repress") (:form . "repress") (:end . 164)\n  (:start . 157) (:id . 64))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 169) (:start . 165)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 178)\n  (:start . 170) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1187.4.1) (:span 18 21)))\n (:nscopes ((:id . :x1187.4.1) (:span 0 178)))\n (:identifiers (:sid . :s1187.4) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011038@unknown@formal@none@1@S@Nor was fragmentation observed after treatment with RU38486, indicating that repression of AP-1 activity is not involved.@(((:tag . "CC") (:stem . "nor") (:form . "Nor") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RU38486") (:form . "RU38486") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1187.5.2) (:span 61 76)))\n (:ncues ((:id . :x1187.5.1) (:span 108 111))\n  ((:id . :x1187.5.3) (:span 0 3)))\n (:hscopes ((:id . :x1187.5.2) (:span 61 120)))\n (:nscopes ((:id . :x1187.5.1) (:span 77 120))\n  ((:id . :x1187.5.3) (:span 0 59)))\n (:identifiers (:sid . :s1187.5) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011040@unknown@formal@none@1@S@However, inhibition of protein synthesis with cycloheximide anytime during the first 18 h of steroid treatment was as effective in blocking chromatin fragmentation as inhibition for the entire period, suggesting that synthesis of a component with a rapid turnover rate is required.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "RB") (:stem . "anytime") (:form . "anytime") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "fragmentation") (:form . "fragmentation")\n  (:end . 163) (:start . 150) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 177)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 192)\n  (:start . 186) (:id . 70))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 199)\n  (:start . 193) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 211)\n  (:start . 201) (:id . 73))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 216) (:start . 212)\n  (:id . 74))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 226)\n  (:start . 217) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 231) (:start . 230)\n  (:id . 77))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 241)\n  (:start . 232) (:id . 78))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 246) (:start . 242)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 248) (:start . 247)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 254)\n  (:start . 249) (:id . 81))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 263)\n  (:start . 255) (:id . 82))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 268) (:start . 264)\n  (:id . 83))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 271) (:start . 269)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 280)\n  (:start . 272) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x1187.7.1) (:span 201 211)))\n (:hscopes ((:id . :x1187.7.1) (:span 201 280)))\n (:identifiers (:sid . :s1187.7) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011041@unknown@formal@none@1@S@Dexamethasone treatment completely blocked 12-O-tetradecanoylphorbol 13-acetate induction of nuclear factor-kappaB (NF-kappaB) activity and elicited an increase in the amount of immunoreactive IkappaB alpha in sensitive 6TG1.1 cells but not in resistant ICR27TK.3 cells.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 34)\n  (:start . 24) (:id . 44))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 42)\n  (:start . 35) (:id . 45))\n ((:tag . "NNP") (:stem . "12-O-tetradecanoylphorbol")\n  (:form . "12-O-tetradecanoylphorbol") (:end . 68) (:start . 43) (:id . 46))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 79)\n  (:start . 69) (:id . 47))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 100)\n  (:start . 93) (:id . 50))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 114) (:start . 101) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 125)\n  (:start . 116) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 135)\n  (:start . 127) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "elicit") (:form . "elicited") (:end . 148)\n  (:start . 140) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 151) (:start . 149)\n  (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 160)\n  (:start . 152) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 61))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 174)\n  (:start . 168) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "immunoreactive") (:form . "immunoreactive")\n  (:end . 192) (:start . 178) (:id . 64))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 200)\n  (:start . 193) (:id . 65))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 206)\n  (:start . 201) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 209) (:start . 207)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 219)\n  (:start . 210) (:id . 68))\n ((:tag . "NN") (:stem . "6tg1.1") (:form . "6TG1.1") (:end . 226)\n  (:start . 220) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 232)\n  (:start . 227) (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 236) (:start . 233)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 240) (:start . 237)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 243) (:start . 241)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 253)\n  (:start . 244) (:id . 74))\n ((:tag . "NN") (:stem . "icr27tk.3") (:form . "ICR27TK.3") (:end . 263)\n  (:start . 254) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 269)\n  (:start . 264) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x1187.8.1) (:span 237 240)))\n (:nscopes ((:id . :x1187.8.1) (:span 237 269)))\n (:identifiers (:sid . :s1187.8) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011042@unknown@formal@none@1@S@In addition, mild detergent treatment of cell extracts indicated that a substantial amount of cytoplasmic NF-kappaB is complexed with IkappaB alpha or some other inhibitory factor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mild") (:form . "mild") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "detergent") (:form . "detergent") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "complexe") (:form . "complexed") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 147)\n  (:start . 142) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 179)\n  (:start . 173) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1187.9.1) (:span 148 150))\n  ((:id . :x1187.9.2) (:span 55 69)))\n (:hscopes ((:id . :x1187.9.1) (:span 134 179))\n  ((:id . :x1187.9.2) (:span 55 179)))\n (:identifiers (:sid . :s1187.9) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011043@unknown@formal@none@1@S@These results suggest that induction of a labile inhibitory factor such as IkappaB alpha may contribute to glucocorticoid-induced apoptosis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "labile") (:form . "labile") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "glucocorticoid-induced")\n  (:form . "glucocorticoid-induced") (:end . 129) (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1187.10.1) (:span 89 92))\n  ((:id . :x1187.10.2) (:span 14 21)))\n (:hscopes ((:id . :x1187.10.1) (:span 89 139))\n  ((:id . :x1187.10.2) (:span 14 139)))\n (:identifiers (:sid . :s1187.10) (:did . :|9724034|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011044@unknown@formal@none@1@S@Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules.@(((:tag . "JJ") (:stem . "peripheral") (:form . "Peripheral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 101)\n  (:start . 94) (:id . 55))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 111)\n  (:start . 102) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1188.1) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011045@unknown@formal@none@1@S@We examined signaling molecules of peripheral blood T lymphocytes obtained from women with breast cancer.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "woman") (:form . "women") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1188.2) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011046@unknown@formal@none@1@S@In 6 of 14 patients, T lymphocytes displayed an impaired ability to translocate NFeB p65 (Rel-A) following activation by anti-CD3 and IL-2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 44))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 10) (:start . 8)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 19)\n  (:start . 11) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 34)\n  (:start . 23) (:id . 49))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "VB") (:stem . "translocate") (:form . "translocate") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . "NNP") (:stem . "NFeB") (:form . "NFeB") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Rel-A") (:form . "Rel-A") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 106)\n  (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1188.3) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011047@unknown@formal@none@1@S@This observation was made despite normal cytoplasmic levels of the Rel-A protein.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Rel-A") (:form . "Rel-A") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1188.4) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011048@unknown@formal@none@1@S@We also detected abnormally low levels of the signaling molecules T-cell receptor (TCR)-zeta, ZAP-70 and p56lck in 4 of 14 breast cancer patients, i.e., defects in T-cell signaling molecules.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "abnormally") (:form . "abnormally") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TCR)-zeta") (:form . "TCR)-zeta") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "zap-70") (:form . "ZAP-70") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p56lck") (:form . "p56lck") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 129)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 160)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 170)\n  (:start . 164) (:id . 72))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 180)\n  (:start . 171) (:id . 73))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 190)\n  (:start . 181) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1188.5) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011050@unknown@formal@none@1@S@MKP-1 inactivates MAP kinase and therefore may interfere with the activation of c-jun and c-fos.@(((:tag . "NN") (:stem . "mkp-1") (:form . "MKP-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inactivate") (:form . "inactivates") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "MAP") (:form . "MAP") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "interfere") (:form . "interfere") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-jun") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "c-fos") (:form . "c-fos") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1188.7.1) (:span 43 46)))\n (:hscopes ((:id . :x1188.7.1) (:span 43 95)))\n (:identifiers (:sid . :s1188.7) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011051@unknown@formal@none@1@S@Abnormalities of I or more signaling molecules were found in 9 of 14 patients; however, only 3 patients had T cells that exhibited all 5 defects.@(((:tag . "NNS") (:stem . "abnormality") (:form . "Abnormalities") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "i") (:form . "I") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 130)\n  (:start . 121) (:id . 66))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 134) (:start . 131)\n  (:id . 67))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 144)\n  (:start . 137) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1188.8) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011052@unknown@formal@none@1@S@Our data have implications for the detection of potentially dysfunctional T cells in patients with cancer.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "implication") (:form . "implications") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "dysfunctional") (:form . "dysfunctional")\n  (:end . 73) (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1188.9.1) (:span 48 59)))\n (:hscopes ((:id . :x1188.9.1) (:span 48 105)))\n (:identifiers (:sid . :s1188.9) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011053@unknown@formal@none@1@S@For example, the analysis of only 1 signaling molecule may allow patients with significant defects in T-cell signaling to go unnoticed.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 90)\n  (:start . 79) (:id . 56))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "VB") (:stem . "go") (:form . "go") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "unnoticed") (:form . "unnoticed") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1188.10.1) (:span 55 58)))\n (:hscopes ((:id . :x1188.10.1) (:span 55 134)))\n (:identifiers (:sid . :s1188.10) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011054@unknown@formal@none@1@S@Finally, despite impaired Rel-A translocation, T cells were capable of transcribing IL-2.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "Rel-A") (:form . "Rel-A") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "transcribe") (:form . "transcribing") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1188.11) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011055@unknown@formal@none@1@S@Impairments in the translocation of Rel-B and c-Rel further suggest that the NFKB family members Rel-A, Rel-B and c-Rel are not required for the transcription of IL-2 in the peripheral T lymphocytes of patients with breast cancer.@(((:tag . "NNS") (:stem . "impairment") (:form . "Impairments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Rel-B") (:form . "Rel-B") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFKB") (:form . "NFKB") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NNP") (:stem . "Rel-A") (:form . "Rel-A") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Rel-B") (:form . "Rel-B") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "c-rel") (:form . "c-Rel") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 158) (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 184)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 198)\n  (:start . 187) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 210)\n  (:start . 202) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . "NN") (:stem . "breast") (:form . "breast") (:end . 222)\n  (:start . 216) (:id . 78))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 229)\n  (:start . 223) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1188.12.2) (:span 60 67)))\n (:ncues ((:id . :x1188.12.1) (:span 124 127)))\n (:hscopes ((:id . :x1188.12.2) (:span 60 229)))\n (:nscopes ((:id . :x1188.12.1) (:span 73 229)))\n (:identifiers (:sid . :s1188.12) (:did . :|9724088|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011056@unknown@formal@none@1@S@Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells.@(((:tag . "NN") (:stem . "transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "SP1") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1189.1) (:did . :|9725220|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011057@unknown@formal@none@1@S@NF-IL6 is an important transcriptional regulator of genes induced in activated monocytes/macrophages, and NF-IL6 is the only CCAAT/enhancer-binding protein (C/EBP) family member whose steady-state mRNA levels increase upon activation of monocytes (1).@(((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "monocytes/macrophage")\n  (:form . "monocytes/macrophages") (:end . 100) (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 112)\n  (:start . 106) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ccaat/enhancer-binding")\n  (:form . "CCAAT/enhancer-binding") (:end . 147) (:start . 125) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "C/EBP") (:form . "C/EBP") (:end . 162)\n  (:start . 157) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 170)\n  (:start . 164) (:id . 65))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 177)\n  (:start . 171) (:id . 66))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 183)\n  (:start . 178) (:id . 67))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 196)\n  (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 201) (:start . 197)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 208)\n  (:start . 202) (:id . 70))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 217)\n  (:start . 209) (:id . 71))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 222) (:start . 218)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 233)\n  (:start . 223) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 246)\n  (:start . 237) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 248) (:start . 247)\n  (:id . 76))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 249) (:start . 248)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 250) (:start . 249)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1189.2) (:did . :|9725220|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011058@unknown@formal@none@1@S@We show that increased transcription of the NF-IL6 gene is responsible, at least in part, for induction of NF-IL6 mRNA following activation of U937 promonocytic cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 103)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 139)\n  (:start . 129) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 160)\n  (:start . 148) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1189.3) (:did . :|9725220|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011060@unknown@formal@none@1@S@This region contains binding sites for the cAMP response element-binding protein/activation transcription factor (CREB/ATF) and Sp1 families of transcription factors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "element-binding") (:form . "element-binding")\n  (:end . 72) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "protein/activation") (:form . "protein/activation")\n  (:end . 91) (:start . 73) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 112)\n  (:start . 106) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CREB/ATF") (:form . "CREB/ATF") (:end . 122)\n  (:start . 114) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 140)\n  (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 165)\n  (:start . 158) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1189.5) (:did . :|9725220|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011061@unknown@formal@none@1@S@Each site is functionally important and contributes independently to transcription of the NF-IL6 gene in U937 cells.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 65) (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-IL6") (:form . "NF-IL6") (:end . 96)\n  (:start . 90) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1189.6) (:did . :|9725220|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011062@unknown@formal@none@1@S@CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.@(((:tag . "NNP") (:stem . "CD30") (:form . "CD30") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cd40-inducible") (:form . "CD40-inducible")\n  (:end . 24) (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . "immunoglobulin")\n  (:end . 88) (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 94) (:start . 89)\n  (:id . 52))\n ((:tag . "NN") (:stem . "switching") (:form . "switching") (:end . 104)\n  (:start . 95) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "non-antigen-selected")\n  (:form . "non-antigen-selected") (:end . 128) (:start . 108) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 134)\n  (:start . 129) (:id . 56))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 136) (:start . 135)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1190.1) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011063@unknown@formal@none@1@S@We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "germinal") (:form . "germinal") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CL-01") (:form . "CL-01") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 89)\n  (:start . 78) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 122) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 138) (:start . 123) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1190.2) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011064@unknown@formal@none@1@S@CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4.@(((:tag . "NN") (:stem . "cl-01") (:form . "CL-01") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "igm+") (:form . "IgM+") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "igd+") (:form . "IgD+") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cd30+") (:form . "CD30+") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IgA") (:form . "IgA") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 68) (:start . 64)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 76)\n  (:start . 69) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 85) (:start . 80)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 94) (:start . 90)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1190.3) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011065@unknown@formal@none@1@S@Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes.@(((:tag . "NN") (:stem . "switching") (:form . "Switching") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "hamper") (:form . "hampered") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "coengagement") (:form . "coengagement") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 96) (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 116) (:start . 97) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 132) (:start . 117) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 143)\n  (:start . 133) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 157)\n  (:start . 147) (:id . 59))\n ((:tag . "JJ") (:stem . "C(H)") (:form . "C(H)") (:end . 162) (:start . 158)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 168)\n  (:start . 163) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1190.4.1) (:span 44 52)))\n (:hscopes ((:id . :x1190.4.1) (:span 44 168)))\n (:identifiers (:sid . :s1190.4) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011066@unknown@formal@none@1@S@The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "emphasize") (:form . "emphasized") (:end . 60)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "cd30-mediated") (:form . "CD30-mediated")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 93)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1190.5) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011067@unknown@formal@none@1@S@Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CD40L") (:form . "CD40L") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "coengagement") (:form . "coengagement") (:end . 102)\n  (:start . 90) (:id . 59))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1190.6) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011068@unknown@formal@none@1@S@Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd30") (:form . "CD30") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "cd40-mediated") (:form . "CD40-mediated")\n  (:end . 65) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 81) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-antigen-selected")\n  (:form . "non-antigen-selected") (:end . 105) (:start . 85) (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 54))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 113) (:start . 112)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1190.7.1) (:span 9 16)))\n (:hscopes ((:id . :x1190.7.1) (:span 9 119)))\n (:identifiers (:sid . :s1190.7) (:did . :|9729045|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011070@unknown@formal@none@1@S@Endotoxin selectively induces monocyte Mn superoxide dismutase (SOD) without affecting levels of Cu,Zn SOD, catalase, or glutathione peroxidase.@(((:tag . "NNP") (:stem . "Endotoxin") (:form . "Endotoxin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "NNP") (:stem . "Mn") (:form . "Mn") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "superoxide") (:form . "superoxide") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "dismutase") (:form . "dismutase") (:end . 62)\n  (:start . 53) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SOD") (:form . "SOD") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Cu,Zn") (:form . "Cu,Zn") (:end . 102)\n  (:start . 97) (:id . 56))\n ((:tag . "NNP") (:stem . "SOD") (:form . "SOD") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "glutathione") (:form . "glutathione") (:end . 132)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "peroxidase") (:form . "peroxidase") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1191.2.1) (:span 69 76)))\n (:nscopes ((:id . :x1191.2.1) (:span 69 143)))\n (:identifiers (:sid . :s1191.2) (:did . :|9730957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011071@unknown@formal@none@1@S@However, little is known about the structure-activity relationship and the mechanism by which endotoxin induces Mn SOD.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "structure-activity") (:form . "structure-activity")\n  (:end . 53) (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "NNP") (:stem . "Mn") (:form . "Mn") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "SOD") (:form . "SOD") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1191.3) (:did . :|9730957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011072@unknown@formal@none@1@S@In this study we demonstrated that a mutant Escherichia coli endotoxin lacking myristoyl fatty acid at the 3' R-3-hydroxymyristate position of the lipid A moiety retained its full capacity to coagulate Limulus amoebocyte lysate compared with the wild-type E. coli endotoxin and markedly stimulated the activation of human monocyte nuclear factor-kappaB and the induction of Mn SOD mRNA and enzyme activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . 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"the") (:end . 301) (:start . 298)\n  (:id . 87))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 312)\n  (:start . 302) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 315) (:start . 313)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 321)\n  (:start . 316) (:id . 90))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 330)\n  (:start . 322) (:id . 91))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 338)\n  (:start . 331) (:id . 92))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 352) (:start . 339) (:id . 93))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 356) (:start . 353)\n  (:id . 94))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 360) (:start . 357)\n  (:id . 95))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 370)\n  (:start . 361) (:id . 96))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 373) (:start . 371)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "Mn") (:form . "Mn") (:end . 376) (:start . 374)\n  (:id . 98))\n ((:tag . "NNP") (:stem . "SOD") (:form . "SOD") (:end . 380) (:start . 377)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 385) (:start . 381)\n  (:id . 100))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 389) (:start . 386)\n  (:id . 101))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 396)\n  (:start . 390) (:id . 102))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 405)\n  (:start . 397) (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 406) (:start . 405)\n  (:id . 104)))@@@1@63@((:ncues ((:id . :x1191.4.1) (:span 71 78)))\n (:nscopes ((:id . :x1191.4.1) (:span 71 161)))\n (:identifiers (:sid . :s1191.4) (:did . :|9730957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011073@unknown@formal@none@1@S@However, in contrast to the wild-type endotoxin, it failed to induce significant production of tumor necrosis factor-alpha and macrophage inflammatory protein-1alpha by monocytes and did not induce the phosphorylation and nuclear translocation of mitogen-activated protein kinase.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 58) (:start . 52)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 150)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "protein-1alpha") (:form . "protein-1alpha")\n  (:end . 165) (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 178)\n  (:start . 169) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 182) (:start . 179)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 186) (:start . 183)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 197)\n  (:start . 191) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 217) (:start . 202) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 229)\n  (:start . 222) (:id . 74))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 243) (:start . 230) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 264) (:start . 247) (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 272)\n  (:start . 265) (:id . 78))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 279)\n  (:start . 273) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x1191.5.1) (:span 187 190))\n  ((:id . :x1191.5.2) (:span 52 58)))\n (:nscopes ((:id . :x1191.5.1) (:span 187 279))\n  ((:id . :x1191.5.2) (:span 52 178)))\n (:identifiers (:sid . :s1191.5) (:did . :|9730957|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011074@unknown@formal@none@1@S@These results suggest that 1) lipid A myristoyl fatty acid, although it is important for the induction of inflammatory cytokine production by human monocytes, is not necessary for the induction of Mn SOD, 2) endotoxin-mediated induction of Mn SOD and inflammatory cytokines are regulated, at least in part, through different signal transduction pathways, and 3) failure of the mutant endotoxin to induce tumor necrosis factor-alpha production is, at least in part, due to its inability to activate mitogen-activated protein kinase.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "LS") (:stem . "1") (:form . 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5011075@unknown@formal@none@1@S@An allosteric drug, o,o'-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 Tat and NF-kappa B.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "allosteric") (:form . "allosteric") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "o,o'-bismyristoyl") (:form . "o,o'-bismyristoyl")\n  (:end . 37) (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "thiamine") (:form . "thiamine") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 94)\n  (:start . 87) (:id . 53))\n ((:tag . "NN") (:stem . "prevention") (:form . "prevention") (:end . 105)\n  (:start . 95) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 116)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 130) (:start . 117) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 58))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 138) (:start . 134)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 144)\n  (:start . 139) (:id . 60))\n ((:tag . "NNP") (:stem . "Tat") (:form . "Tat") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 161)\n  (:start . 153) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 163) (:start . 162)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1192.1) (:did . :|9731208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011076@unknown@formal@none@1@S@The efficacy of o,o'-bismyristoyl thiamine disulfide (BMT) was examined in detail against HIV-1 laboratory isolates (HTLV-IIIB, JRFL, and MN), primary isolates (KMT and KMO), and simian immunodeficiency virus (SIVmac251) in vitro.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "o,o'-bismyristoyl") (:form . "o,o'-bismyristoyl")\n  (:end . 33) (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "thiamine") (:form . "thiamine") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "disulfide") (:form . "disulfide") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "BMT") (:form . "BMT") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HTLV-IIIB") (:form . "HTLV-IIIB") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "JRFL") (:form . "JRFL") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "MN") (:form . "MN") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 150)\n  (:start . 143) (:id . 68))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "KMT") (:form . "KMT") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 168) (:start . 165)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "KMO") (:form . "KMO") (:end . 172) (:start . 169)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "simian") (:form . "simian") (:end . 185)\n  (:start . 179) (:id . 77))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 202) (:start . 186) (:id . 78))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 208)\n  (:start . 203) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "SIVmac251") (:form . "SIVmac251") (:end . 219)\n  (:start . 210) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 82))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 83))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 229)\n  (:start . 224) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1192.2) (:did . :|9731208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011077@unknown@formal@none@1@S@BMT inhibited the replication of HIV-1 in both laboratory and primary isolates in vitro.@(((:tag . "NNP") (:stem . "BMT") (:form . "BMT") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "laboratory") (:form . "laboratory") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "isolate") (:form . "isolates") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1192.3) (:did . :|9731208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011078@unknown@formal@none@1@S@In addition, BMT exhibited antiviral activity against SIVmac251.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "bmt") (:form . "BMT") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "antiviral") (:form . "antiviral") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "SIVmac251") (:form . "SIVmac251") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1192.4) (:did . :|9731208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011080@unknown@formal@none@1@S@BMT inhibits nuclear translocation of both HIV-1 transactivator (TAT) and the cellular transcriptional nuclear factor-KB (NF-kappa B), resulting in the suppression of HIV-1 replication.@(((:tag . "NNP") (:stem . "BMT") (:form . "BMT") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 63) (:start . 49) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TAT") (:form . "TAT") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 102) (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "factor-kb") (:form . "factor-KB") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 130)\n  (:start . 122) (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 163)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 184)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1192.6) (:did . :|9731208|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011081@unknown@formal@none@1@S@Retinoid X receptor and c-cerbA/thyroid hormone receptor regulate erythroid cell growth and differentiation.@(((:tag . "NNP") (:stem . "Retinoid") (:form . "Retinoid") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "c-cerba/thyroid") (:form . "c-cerbA/thyroid")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 47)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 80) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 107) (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1193.1) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011082@unknown@formal@none@1@S@Nuclear receptors are important regulators of erythroid cell development.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 72)\n  (:start . 61) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1193.2) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011083@unknown@formal@none@1@S@Here we investigated the impact of retinoid X receptor (RXR), retinoic acid receptor (RAR), and of the c-erbA/thyroid hormone (T3) receptor (c-erbA/TR) on growth and differentiation of erythroid cells using an in vitro culture system of stem cell factor-dependent erythroid progenitors.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "retinoid") (:form . "retinoid") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . 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"cells") (:end . 200)\n  (:start . 195) (:id . 80))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 206) (:start . 201)\n  (:id . 81))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 209) (:start . 207)\n  (:id . 82))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 83))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 218)\n  (:start . 213) (:id . 84))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 226)\n  (:start . 219) (:id . 85))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 233)\n  (:start . 227) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 87))\n ((:tag . "NN") (:stem . "stem") (:form . "stem") (:end . 241) (:start . 237)\n  (:id . 88))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 246) (:start . 242)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "factor-dependent") (:form . "factor-dependent")\n  (:end . 263) (:start . 247) (:id . 90))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 273)\n  (:start . 264) (:id . 91))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 285)\n  (:start . 274) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s1193.3) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011084@unknown@formal@none@1@S@RXR, RAR, and c-erbA/TR-specific ligands were found to induce erythroid-specific gene expression and to accelerate erythroid differentiation in culture, with T3 being most effective.@(((:tag . "NNP") (:stem . "RXR") (:form . "RXR") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "RAR") (:form . "RAR") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "c-erba/tr-specific") (:form . "c-erbA/TR-specific")\n  (:end . 32) (:start . 14) (:id . 47))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "erythroid-specific") (:form . "erythroid-specific")\n  (:end . 80) (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "VB") (:stem . "accelerate") (:form . "accelerate") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 140) (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 61))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t3") (:form . "T3") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 166) (:start . 161)\n  (:id . 66))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 171) (:start . 167)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1193.4) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011085@unknown@formal@none@1@S@Furthermore, while ligand-activated c-erbA/TR accelerated differentiation, unliganded c-erbA/TR effectively blocked differentiation and supported sustained progenitor growth in culture.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ligand-activated") (:form . "ligand-activated")\n  (:end . 35) (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "c-erbA/TR") (:form . "c-erbA/TR") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "VBD") (:stem . "accelerate") (:form . "accelerated") (:end . 57)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 73) (:start . 58) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unliganded") (:form . "unliganded") (:end . 85)\n  (:start . 75) (:id . 50))\n ((:tag . "NNP") (:stem . "c-erbA/TR") (:form . "c-erbA/TR") (:end . 95)\n  (:start . 86) (:id . 51))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 107)\n  (:start . 96) (:id . 52))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 115)\n  (:start . 108) (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 131) (:start . 116) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "support") (:form . "supported") (:end . 145)\n  (:start . 136) (:id . 56))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 155)\n  (:start . 146) (:id . 57))\n ((:tag . "NN") (:stem . "progenitor") (:form . "progenitor") (:end . 166)\n  (:start . 156) (:id . 58))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 173)\n  (:start . 167) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 60))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 184)\n  (:start . 177) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1193.5) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011086@unknown@formal@none@1@S@Thus, c-erbA/TR appears to act as a binary switch affecting erythroid cell fate: unliganded c-erbA/TR supports growth while ligand-activated c-erbA/TR induces differentiation.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "c-erbA/TR") (:form . "c-erbA/TR") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fate") (:form . "fate") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unliganded") (:form . "unliganded") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "NNP") (:stem . "c-erbA/TR") (:form . "c-erbA/TR") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 117)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "JJ") (:stem . "ligand-activated") (:form . "ligand-activated")\n  (:end . 140) (:start . 124) (:id . 62))\n ((:tag . "NNP") (:stem . "c-erbA/TR") (:form . "c-erbA/TR") (:end . 150)\n  (:start . 141) (:id . 63))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 158)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 174) (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1193.6.1) (:span 16 23)))\n (:hscopes ((:id . :x1193.6.1) (:span 6 79)))\n (:identifiers (:sid . :s1193.6) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011087@unknown@formal@none@1@S@Additionally, to determine the impact of RXR for erythroid cell development, dominant interfering mutant RXRs, lacking the transcriptional activator functions AF-1 and AF-2, or AF-2 only, or the entire DNA-binding domain, were introduced into erythroid progenitor cells via recombinant retrovirus vectors and analyzed for RXR-specific effects.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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"vectors") (:end . 304)\n  (:start . 297) (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 308) (:start . 305)\n  (:id . 89))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 317)\n  (:start . 309) (:id . 90))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 321) (:start . 318)\n  (:id . 91))\n ((:tag . "JJ") (:stem . "rxr-specific") (:form . "RXR-specific") (:end . 334)\n  (:start . 322) (:id . 92))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 342)\n  (:start . 335) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 343) (:start . 342)\n  (:id . 94)))@@@1@53@((:ncues ((:id . :x1193.7.1) (:span 111 118)))\n (:nscopes ((:id . :x1193.7.1) (:span 111 220)))\n (:identifiers (:sid . :s1193.7) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011088@unknown@formal@none@1@S@It was found that expression of wild-type RXR and of the RXR mutants devoid of AF-1 and/or AF-2 supported a transient outgrowth of erythroid cells.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "rxr") (:form . "RXR") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rxr") (:form . "RXR") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "JJ") (:stem . "devoid") (:form . "devoid") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "AF-1") (:form . "AF-1") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 90)\n  (:start . 84) (:id . 58))\n ((:tag . "NNP") (:stem . "AF-2") (:form . "AF-2") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "support") (:form . "supported") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 117)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1193.8) (:did . :|9731697|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011090@unknown@formal@none@1@S@Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide.@(((:tag . "NNP") (:stem . "Phosphatidylinositide")\n  (:form . "Phosphatidylinositides") (:end . 22) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 27) (:start . 23)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 100)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 119) (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1194.1) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011091@unknown@formal@none@1@S@Although bacterial lipopolysaccharides (LPS) and several other microbial agonists can bind to mCD14 (membrane CD14), a cell-surface receptor found principally on monocytes and neutrophils, host-derived mCD14 ligands are poorly defined.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "lipopolysaccharide")\n  (:form . "lipopolysaccharides") (:end . 38) (:start . 19) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 43) (:start . 40)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "agonist") (:form . "agonists") (:end . 81)\n  (:start . 73) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "cd14") (:form . "CD14") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cell-surface") (:form . "cell-surface") (:end . 131)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "RB") (:stem . "principally") (:form . "principally") (:end . 158)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 171)\n  (:start . 162) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 187)\n  (:start . 176) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "host-derived") (:form . "host-derived") (:end . 201)\n  (:start . 189) (:id . 72))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 207)\n  (:start . 202) (:id . 73))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 215)\n  (:start . 208) (:id . 74))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 226)\n  (:start . 220) (:id . 76))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 234)\n  (:start . 227) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1194.2) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011092@unknown@formal@none@1@S@We report here that phosphatidylinositol (PtdIns), phosphatidylinositol-4-phosphate, and other phosphatidylinositides can bind to mCD14.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phosphatidylinositol")\n  (:form . "phosphatidylinositol") (:end . 40) (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "phosphatidylinositol-4-phosphate")\n  (:form . "phosphatidylinositol-4-phosphate") (:end . 83) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "phosphatidylinositide")\n  (:form . "phosphatidylinositides") (:end . 117) (:start . 95) (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 121) (:start . 118)\n  (:id . 56))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 126) (:start . 122)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 58))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 135)\n  (:start . 130) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1194.3) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011093@unknown@formal@none@1@S@Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent affinity than does PtdIns.@(((:tag . "NNP") (:stem . "Phosphatidylserine") (:form . "Phosphatidylserine")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PS") (:form . "PS") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "JJ") (:stem . "anionic") (:form . "anionic") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "glycerophospholipid")\n  (:form . "glycerophospholipid") (:end . 60) (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1194.4) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011094@unknown@formal@none@1@S@LPS-binding protein, a lipid transfer protein found in serum, facilitates both PS- and PtdIns-mCD14 binding.@(((:tag . "JJ") (:stem . "lps-binding") (:form . "LPS-binding") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "facilitate") (:form . "facilitates") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ps-") (:form . "PS-") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ptdins-mcd14") (:form . "PtdIns-mCD14") (:end . 99)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1194.5) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011095@unknown@formal@none@1@S@PtdIns binding to mCD14 can be blocked by anti-CD14 monoclonal antibodies that inhibit LPS-mCD14 binding, and PtdIns can inhibit both LPS-mCD14 binding and LPS-induced responses in monocytes.@(((:tag . "NN") (:stem . "ptdins") (:form . "PtdIns") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-cd14") (:form . "anti-CD14") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "lps-mcd14") (:form . "LPS-mCD14") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lps-mcd14") (:form . "LPS-mCD14") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 151)\n  (:start . 144) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 167)\n  (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 177)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 190)\n  (:start . 181) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1194.6) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011096@unknown@formal@none@1@S@Serum-equilibrated PtdIns also binds to mCD14-expressing cells, raising the possibility that endogenous PtdIns may modulate cellular responses to LPS and other mCD14 ligands in vivo.@(((:tag . "JJ") (:stem . "serum-equilibrated") (:form . "Serum-equilibrated")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 25)\n  (:start . 19) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 30) (:start . 26)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mcd14-expressing") (:form . "mCD14-expressing")\n  (:end . 56) (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "raise") (:form . "raising") (:end . 71)\n  (:start . 64) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "ptdins") (:form . "PtdIns") (:end . 110)\n  (:start . 104) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 114) (:start . 111)\n  (:id . 56))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 123)\n  (:start . 115) (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 142)\n  (:start . 133) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 159)\n  (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "mcd14") (:form . "mCD14") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 173)\n  (:start . 166) (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 181) (:start . 177)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1194.7.1) (:span 111 114))\n  ((:id . :x1194.7.2) (:span 64 87)))\n (:hscopes ((:id . :x1194.7.1) (:span 111 181))\n  ((:id . :x1194.7.2) (:span 64 181)))\n (:identifiers (:sid . :s1194.7) (:did . :|9733716|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011097@unknown@formal@none@1@S@Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis in lymphoblastoid T-cell-line-expressing wild-type and mutated CD4 receptors.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 57) (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "virus-induced") (:form . "virus-induced")\n  (:end . 71) (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 81)\n  (:start . 72) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 99) (:start . 85) (:id . 52))\n ((:tag . "JJ") (:stem . "t-cell-line-expressing")\n  (:form . "T-cell-line-expressing") (:end . 122) (:start . 100) (:id . 53))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 132)\n  (:start . 123) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 144)\n  (:start . 137) (:id . 56))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 148) (:start . 145)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 158)\n  (:start . 149) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1195.1) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011098@unknown@formal@none@1@S@We have previously shown that the presence of the CD4 cytoplasmic tail is critical for human immunodeficiency virus (HIV)-induced apoptosis (J.Corbeil, M.Tremblay, and D.D.Richman, J.Exp.Med.183:39-48, 1996).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 109) (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "HIV)-induced") (:form . "HIV)-induced")\n  (:end . 129) (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "J.Corbeil") (:form . "J.Corbeil") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "M.Tremblay") (:form . "M.Tremblay") (:end . 162)\n  (:start . 152) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "D.D.Richman") (:form . "D.D.Richman") (:end . 179)\n  (:start . 168) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "CD") (:stem . "J.Exp.Med.183:39-48")\n  (:form . "J.Exp.Med.183:39-48") (:end . 200) (:start . 181) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 201) (:start . 200)\n  (:id . 72))\n ((:tag . "CD") (:stem . "1996") (:form . "1996") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1195.2) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011100@unknown@formal@none@1@S@To do this, wild-type and mutant forms of the CD4 cytoplasmic tail were stably expressed in the lymphoblastoid T-cell line A2.01.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 21)\n  (:start . 12) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "NNS") (:stem . "form") (:form . "forms") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 61)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 78)\n  (:start . 72) (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 110) (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "a2.01") (:form . "A2.01") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1195.4) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011101@unknown@formal@none@1@S@Apoptosis was prevented when CD4 truncated at residue 402 was expressed; however, cells expressing mutated receptors that do not associate with p56(lck) (mutated at the dicysteine motif and truncated at residue 418) but which conserved proximal domains of the cytoplasmic tail underwent apoptosis like wild- type CD4.@(((:tag . "NNP") (:stem . "Apoptosis") (:form . "Apoptosis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . 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5011103@unknown@formal@none@1@S@Initial signaling through the CD4 receptor played a major role in the sensitization of HIV-infected T cells to undergo apoptosis.@(((:tag . "JJ") (:stem . "initial") (:form . "Initial") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "play") (:form . "played") (:end . 49) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sensitization") (:form . "sensitization")\n  (:end . 83) (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VB") (:stem . "undergo") (:form . "undergo") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1195.7) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011104@unknown@formal@none@1@S@Incubation of HIV-infected cells with monoclonal antibody (MAb) 13B8-2, which binds to CD4 in a region critical for dimerization of the receptor, prevented apoptosis without inhibiting HIV replication.@(((:tag . "NN") (:stem . "incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hiv-infected") (:form . "HIV-infected") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MAb") (:form . "MAb") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "13b8-2") (:form . "13B8-2") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 128)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 155)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 173)\n  (:start . 166) (:id . 70))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 184)\n  (:start . 174) (:id . 71))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 188) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 200)\n  (:start . 189) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1195.8.1) (:span 166 173)))\n (:nscopes ((:id . :x1195.8.1) (:span 166 200)))\n (:identifiers (:sid . :s1195.8) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
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5011106@unknown@formal@none@1@S@These observations demonstrate that CD4 signaling mediates HIV-induced apoptosis by a mechanism independent of Fas-Fas ligand interaction, does not require p56(lck) signaling, and may involve a critical region for CD4 dimerization.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "JJ") (:stem . "hiv-induced") (:form . "HIV-induced") (:end . 70)\n  (:start . 59) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 80)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 95)\n  (:start . 86) (:id . 53))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 107)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "fas-fas") (:form . "Fas-Fas") (:end . 118)\n  (:start . 111) (:id . 56))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 125)\n  (:start . 119) (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 137)\n  (:start . 126) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 61))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 155)\n  (:start . 148) (:id . 62))\n ((:tag . "VBN") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 164)\n  (:start . 156) (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 174)\n  (:start . 165) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 191)\n  (:start . 184) (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 193) (:start . 192)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 202)\n  (:start . 194) (:id . 70))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 209)\n  (:start . 203) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 213) (:start . 210)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 230)\n  (:start . 218) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1195.10.1) (:span 180 183)))\n (:ncues ((:id . :x1195.10.2) (:span 144 147)))\n (:hscopes ((:id . :x1195.10.1) (:span 180 230)))\n (:nscopes ((:id . :x1195.10.2) (:span 144 174)))\n (:identifiers (:sid . :s1195.10) (:did . :|9733846|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011107@unknown@formal@none@1@S@Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cd3+cd28-induced") (:form . "CD3+CD28-induced")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 34) (:start . 21) (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 45)\n  (:start . 35) (:id . 45))\n ((:tag . "VBZ") (:stem . "correlate") (:form . "correlates") (:end . 56)\n  (:start . 46) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 71)\n  (:start . 62) (:id . 48))\n ((:tag . "JJ") (:stem . "reactive") (:form . "reactive") (:end . 80)\n  (:start . 72) (:id . 49))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 87)\n  (:start . 81) (:id . 50))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 100)\n  (:start . 88) (:id . 51))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 110)\n  (:start . 101) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 122)\n  (:start . 114) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 124) (:start . 123)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1196.1) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011108@unknown@formal@none@1@S@The capacity of neonatal T cells to secrete interleukin-2 (IL-2) has been reported to be variable.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "secrete") (:form . "secrete") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 57) (:start . 44) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 97)\n  (:start . 89) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1196.2) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011110@unknown@formal@none@1@S@PDBu + iono induced equally high IL-2 levels in both groups and, when stimulated with plate-bound anti-CD3 monoclonal antibody (mAb), the IL-2 secretion by neonatal cells was undetectable and adult cells produced low amounts of IL-2 (mean 331 ± 86 pg/ml).@(((:tag . "NN") (:stem . "pdbu") (:form . "PDBu") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "iono") (:form . "iono") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "RB") (:stem . "equally") (:form . "equally") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 80)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "plate-bound") (:form . "plate-bound") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 142) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 152)\n  (:start . 143) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 164)\n  (:start . 156) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 187)\n  (:start . 175) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 197)\n  (:start . 192) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 76))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 212)\n  (:start . 204) (:id . 77))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 216) (:start . 213)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 224)\n  (:start . 217) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 80))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 232) (:start . 228)\n  (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 234) (:start . 233)\n  (:id . 82))\n ((:tag . "NN") (:stem . "mean") (:form . "mean") (:end . 238) (:start . 234)\n  (:id . 83))\n ((:tag . "CD") (:stem . "331") (:form . "331") (:end . 242) (:start . 239)\n  (:id . 84))\n ((:tag . "HYPH") (:stem . "±") (:form . "±") (:end . 244) (:start . 243)\n  (:id . 85))\n ((:tag . "CD") (:stem . "86") (:form . "86") (:end . 247) (:start . 245)\n  (:id . 86))\n ((:tag . "NN") (:stem . "pg/ml") (:form . "pg/ml") (:end . 253)\n  (:start . 248) (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 254) (:start . 253)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s1196.4) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011111@unknown@formal@none@1@S@The addition of anti-CD28 mAb to anti-CD3-stimulated cells markedly increased IL-2 production in both cell types, but levels of IL-2 in neonatal T cells remained clearly lower than those of adult T cells (respective mean values: 385 ± 109 pg/ml and 4494 ± 1199 pg/ml).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-cd3-stimulated")\n  (:form . "anti-CD3-stimulated") (:end . 52) (:start . 33) (:id . 48))\n ((:tag . 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5011112@unknown@formal@none@1@S@As NF-kappa B is a critical transcription factor in the control of IL-2 expression, we next analysed its nuclear translocation in neonatal and adult T cells using the electrophoretic mobility shift assay and, because induction of reactive oxygen intermediates (ROI) is required for the activation of NF-kappa B, we also analysed levels of intracellular ROI in these cells using the ROI-reactive fluorochrome DCFH-DA and flow cytometry.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "critical") (:form . 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5011113@unknown@formal@none@1@S@In neonatal T cells NF-kappa B activation and ROI formation after anti-CD3 stimulation were low compared with adult T cells and, although addition of anti-CD28 mAb increased induction of NF-kappa B and ROI formation, levels similar to those of adults were not achieved.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 115)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 173)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 183)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 195)\n  (:start . 187) (:id . 72))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 205) (:start . 202)\n  (:id . 75))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 215)\n  (:start . 206) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 223)\n  (:start . 217) (:id . 78))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 231)\n  (:start . 224) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 234) (:start . 232)\n  (:id . 80))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 240)\n  (:start . 235) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 250)\n  (:start . 244) (:id . 83))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 255) (:start . 251)\n  (:id . 84))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 259) (:start . 256)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 268)\n  (:start . 260) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 87)))@@@1@46@((:ncues ((:id . :x1196.7.1) (:span 256 259)))\n (:nscopes ((:id . :x1196.7.1) (:span 217 268)))\n (:identifiers (:sid . :s1196.7) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011114@unknown@formal@none@1@S@After PDBu + iono stimulation, the cells showed similar ROI formation and IL-2 secretion.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pdbu") (:form . "PDBu") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CC") (:stem . "+") (:form . "+") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "iono") (:form . "iono") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 47) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "ROI") (:form . "ROI") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1196.8) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011115@unknown@formal@none@1@S@Our results suggest that reduced IL-2 production by neonatal T cells is specific for anti-CD3 and anti-CD3+ anti-CD28-mediated stimulation and that these activators cannot effectively activate the ROI-NF-kappa B signalling pathway in neonatal T cells.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "anti-cd3+") (:form . "anti-CD3+") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "JJ") (:stem . "anti-cd28-mediated") (:form . "anti-CD28-mediated")\n  (:end . 126) (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 138)\n  (:start . 127) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 153)\n  (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 164)\n  (:start . 154) (:id . 64))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 171)\n  (:start . 165) (:id . 65))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 183)\n  (:start . 172) (:id . 66))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 192)\n  (:start . 184) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "ROI-NF-kappa") (:form . "ROI-NF-kappa")\n  (:end . 209) (:start . 197) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 211) (:start . 210)\n  (:id . 70))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 222)\n  (:start . 212) (:id . 71))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 230)\n  (:start . 223) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "neonatal") (:form . "neonatal") (:end . 242)\n  (:start . 234) (:id . 74))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 244) (:start . 243)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 250)\n  (:start . 245) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1196.9.2) (:span 12 19)))\n (:ncues ((:id . :x1196.9.1) (:span 165 171)))\n (:hscopes ((:id . :x1196.9.2) (:span 12 250)))\n (:nscopes ((:id . :x1196.9.1) (:span 165 250)))\n (:identifiers (:sid . :s1196.9) (:did . :|9741337|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011116@unknown@formal@none@1@S@Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells [see comments]@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 47)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 57)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 67)\n  (:start . 58) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 79)\n  (:start . 72) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 107) (:start . 94) (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 116)\n  (:start . 108) (:id . 54))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 127)\n  (:start . 117) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 130) (:start . 128)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 142)\n  (:start . 131) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 150) (:start . 149)\n  (:id . 59))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 153) (:start . 150)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 162)\n  (:start . 154) (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 163) (:start . 162)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1197.1) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011117@unknown@formal@none@1@S@BACKGROUND: Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "platelet/endothelium")\n  (:form . "Platelet/endothelium") (:end . 32) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 44)\n  (:start . 33) (:id . 45))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 50) (:start . 45)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 91) (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 107)\n  (:start . 95) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 55))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 127) (:start . 112) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1197.2) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011118@unknown@formal@none@1@S@The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 182)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1197.3) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011120@unknown@formal@none@1@S@In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adp-activated") (:form . "ADP-activated")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 113) (:start . 100) (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 132)\n  (:start . 124) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nonstimulated") (:form . "nonstimulated")\n  (:end . 151) (:start . 138) (:id . 61))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 161)\n  (:start . 152) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 63))\n ((:tag . "NN") (:stem . "P<0.02") (:form . "P<0.02") (:end . 169)\n  (:start . 163) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1197.5) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011121@unknown@formal@none@1@S@Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 60) (:start . 47) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 102) (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 117)\n  (:start . 112) (:id . 56))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 144) (:start . 128) (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 160) (:start . 145) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 169)\n  (:start . 161) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 173) (:start . 170)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 182)\n  (:start . 174) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 65))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 198)\n  (:start . 190) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 211)\n  (:start . 202) (:id . 68))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 221)\n  (:start . 212) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1197.6) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011122@unknown@formal@none@1@S@In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adp-activated") (:form . "ADP-activated")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "promoter-dependent") (:form . "promoter-dependent")\n  (:end . 80) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 94) (:start . 81) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1197.7) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011123@unknown@formal@none@1@S@Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).@(((:tag . "JJ") (:stem . "liposomal") (:form . "Liposomal") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "double-stranded") (:form . "double-stranded")\n  (:end . 43) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "phosphorothioate") (:form . "phosphorothioate")\n  (:end . 67) (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 83) (:start . 68) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 88) (:start . 85)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 107)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 112) (:start . 108)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 139)\n  (:start . 130) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 151)\n  (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 64))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 172)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 175) (:start . 173)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 185)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 197)\n  (:start . 186) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "P<0.05") (:form . "P<0.05") (:end . 205)\n  (:start . 199) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1197.8.1) (:span 89 92)))\n (:nscopes ((:id . :x1197.8.1) (:span 89 112)))\n (:identifiers (:sid . :s1197.8) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011124@unknown@formal@none@1@S@CONCLUSIONS: The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "platelet") (:form . "platelets") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "VBP") (:stem . "modulate") (:form . "modulate") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "JJ") (:stem . "chemotactic") (:form . "chemotactic") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mcp-1") (:form . "MCP-1") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adhesive") (:form . "adhesive") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 115)\n  (:start . 109) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 142)\n  (:start . 131) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 175) (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1197.9.1) (:span 31 45)))\n (:hscopes ((:id . :x1197.9.1) (:span 31 185)))\n (:identifiers (:sid . :s1197.9) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011125@unknown@formal@none@1@S@Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.@(((:tag . "JJ") (:stem . "platelet-induced") (:form . "Platelet-induced")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 27)\n  (:start . 17) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 90)\n  (:start . 78) (:id . 52))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 97)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 114) (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x1197.10.1) (:span 52 57)))\n (:hscopes ((:id . :x1197.10.1) (:span 52 114)))\n (:identifiers (:sid . :s1197.10) (:did . :|9743506|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011126@unknown@formal@none@1@S@Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.@(((:tag . "VBN") (:stem . "alter") (:form . "Altered") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 31)\n  (:start . 20) (:id . 44))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "eklf") (:form . "EKLF") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 105)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1198.1) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011127@unknown@formal@none@1@S@The locus control region of the beta-globin cluster contains five DNase I hypersensitive sites (5'HS1-5) required for locus activation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 88) (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "5'HS1-5") (:form . "5'HS1-5") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1198.2) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011128@unknown@formal@none@1@S@5'HS3 contains six G-rich motifs that are essential for its activity.@(((:tag . "NNP") (:stem . "5'HS3") (:form . "5'HS3") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "g-rich") (:form . "G-rich") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1198.3) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011130@unknown@formal@none@1@S@Because point mutagenesis cannot distinguish between family members, it is not known which protein activates 5'HS3.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 32)\n  (:start . 26) (:id . 45))\n ((:tag . "VB") (:stem . "distinguish") (:form . "distinguish") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "5'hs3") (:form . "5'HS3") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1198.5.1) (:span 75 84)))\n (:ncues ((:id . :x1198.5.2) (:span 26 32)))\n (:hscopes ((:id . :x1198.5.1) (:span 75 114)))\n (:nscopes ((:id . :x1198.5.2) (:span 26 67)))\n (:identifiers (:sid . :s1198.5) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011131@unknown@formal@none@1@S@We show that the function of such closely related proteins can be distinguished in vivo by matching point mutations in 5'HS3 with amino acid changes in the zinc fingers of Sp1 and EKLF.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "distinguish") (:form . "distinguished") (:end . 79)\n  (:start . 66) (:id . 54))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "match") (:form . "matching") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "5'hs3") (:form . "5'HS3") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 168)\n  (:start . 161) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 184) (:start . 180)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1198.6) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011132@unknown@formal@none@1@S@Testing their activity in transgenic mice shows that EKLF is a direct activator of 5'HS3.@(((:tag . "VBG") (:stem . "test") (:form . "Testing") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "eklf") (:form . "EKLF") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "5'HS3") (:form . "5'HS3") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1198.7) (:did . :|9744863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011133@unknown@formal@none@1@S@NF-kappaB only partially mediates Epstein-Barr virus latent membrane protein 1 activation of B cells.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 46)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 52) (:start . 47)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 78) (:start . 77)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1199.1) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011134@unknown@formal@none@1@S@The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is required for EBV-induced immortalization of human B cells and causes tumorigenic transformation of cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 52)\n  (:start . 40) (:id . 51))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 76)\n  (:start . 68) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ebv-induced") (:form . "EBV-induced") (:end . 92)\n  (:start . 81) (:id . 59))\n ((:tag . "NN") (:stem . "immortalization") (:form . "immortalization")\n  (:end . 108) (:start . 93) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 136)\n  (:start . 130) (:id . 66))\n ((:tag . "JJ") (:stem . "tumorigenic") (:form . "tumorigenic") (:end . 148)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 163) (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1199.2) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011135@unknown@formal@none@1@S@LMP1 expression induces phenotypic changes resembling B cell activation, such as cell size increase and up-regulation of cell surface activation markers.@(((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 117) (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1199.3) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011136@unknown@formal@none@1@S@LMP1 contains two domains that activate the transcription factor NF-kappaB, one through interactions with TRAF proteins and the other with the TRADD protein.@(((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 100)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 133)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "TRADD") (:form . "TRADD") (:end . 148)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1199.4) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011137@unknown@formal@none@1@S@The purpose of the present study was to investigate the importance of NF-kappaB induction in the up-regulation of the B cell activation markers ICAM-1 and CD71 by LMP1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 51)\n  (:start . 40) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 110) (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "icam-1") (:form . "ICAM-1") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CD71") (:form . "CD71") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1199.5) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011138@unknown@formal@none@1@S@This study shows that expression of LMP1 activates transcription from p50/p65- and c-Rel- responsive promoters, and that this activity can be completely inhibited by expression of a dominant inhibitory IkappaB mutant.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LMP1") (:form . "LMP1") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 64) (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p50/p65-") (:form . "p50/p65-") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "c-rel-") (:form . "c-Rel-") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 162)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 176)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 190)\n  (:start . 182) (:id . 70))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 201)\n  (:start . 191) (:id . 71))\n ((:tag . "NN") (:stem . "ikappab") (:form . "IkappaB") (:end . 209)\n  (:start . 202) (:id . 72))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 216)\n  (:start . 210) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1199.6) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011140@unknown@formal@none@1@S@Furthermore, LMP1-induced cell size increase of primary B cells was unaffected by IkappaB expression.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lmp1-induced") (:form . "LMP1-induced") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1199.8) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011141@unknown@formal@none@1@S@It was concluded that even when LMP1 is unable to activate NF-kappaB, it is still capable of inducing certain characteristics of activated B cells, strongly suggesting that LMP1 can also activate cells independently of NF-kappaB.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 125) (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 156)\n  (:start . 148) (:id . 68))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 167)\n  (:start . 157) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 181) (:start . 178)\n  (:id . 72))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 186) (:start . 182)\n  (:id . 73))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 195)\n  (:start . 187) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 201)\n  (:start . 196) (:id . 75))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 215) (:start . 202) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 228)\n  (:start . 219) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1199.9.1) (:span 157 167)))\n (:ncues ((:id . :x1199.9.2) (:span 40 46)))\n (:hscopes ((:id . :x1199.9.1) (:span 157 228)))\n (:nscopes ((:id . :x1199.9.2) (:span 32 68)))\n (:identifiers (:sid . :s1199.9) (:did . :|9747720|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011142@unknown@formal@none@1@S@Activation of distinct transcription factors in neutrophils by bacterial LPS, interferon-gamma, and GM-CSF and the necessity to overcome the action of endogenous proteases.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 36) (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 76) (:start . 73)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interferon-gamma") (:form . "interferon-gamma")\n  (:end . 94) (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 106)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "necessity") (:form . "necessity") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 60))\n ((:tag . "VB") (:stem . "overcome") (:form . "overcome") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 161)\n  (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 171)\n  (:start . 162) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1200.1) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011143@unknown@formal@none@1@S@Human neutrophils can be induced to actively transcribe a number of early-response genes, in particular those encoding cytokines, chemokines, and the high-affinity surface receptor for IgG, FcgammaRI.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "actively") (:form . "actively") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VB") (:stem . "transcribe") (:form . "transcribe") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "early-response") (:form . "early-response")\n  (:end . 82) (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "chemokine") (:form . "chemokines") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 163) (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 171)\n  (:start . 164) (:id . 67))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 180)\n  (:start . 172) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IgG") (:form . "IgG") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "FcgammaRI") (:form . "FcgammaRI") (:end . 199)\n  (:start . 190) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1200.2) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011144@unknown@formal@none@1@S@Although little is known to date about the regulation of gene transcription in neutrophils, several indications point to a role for distinct transcription factors, such as members of the NF-kappaB and STAT families.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 75) (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "indication") (:form . "indications") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "VBP") (:stem . "point") (:form . "point") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 154) (:start . 141) (:id . 65))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 171) (:start . 169)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 179)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 196)\n  (:start . 187) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 214)\n  (:start . 206) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1200.3) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011145@unknown@formal@none@1@S@In this study, we investigated whether these transcription factors become activated under stimulatory conditions which are known to induce gene transcription in neutrophils.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "stimulatory") (:form . "stimulatory") (:end . 101)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 118)\n  (:start . 113) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 60))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 138)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 157) (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 172)\n  (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1200.4.1) (:span 31 38)))\n (:hscopes ((:id . :x1200.4.1) (:span 31 172)))\n (:identifiers (:sid . :s1200.4) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011146@unknown@formal@none@1@S@Unexpectedly, we found that conventional procedures employed to prepare cellular extracts cause the release of proteolytic activities that are normally stored in intracellular granules, resulting in the degradation of various NF-kappaB/Rel and STAT proteins.@(((:tag . "RB") (:stem . "unexpectedly") (:form . "Unexpectedly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "conventional") (:form . "conventional") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "procedure") (:form . "procedures") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "prepare") (:form . "prepare") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 122)\n  (:start . 111) (:id . 58))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 133)\n  (:start . 123) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "VBN") (:stem . "store") (:form . "stored") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 175) (:start . 162) (:id . 65))\n ((:tag . "NNS") (:stem . "granule") (:form . "granules") (:end . 184)\n  (:start . 176) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 195)\n  (:start . 186) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 70))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 214)\n  (:start . 203) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 225)\n  (:start . 218) (:id . 73))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 239) (:start . 226) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 248) (:start . 244)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 257)\n  (:start . 249) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1200.5) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011147@unknown@formal@none@1@S@To circumvent this problem, we developed an alternative procedure which allowed us to show that in neutrophils, LPS and TNFalpha induce a NF-kappaB DNA-binding activity which essentially consists of p50/RelA dimers, and that IFNgamma promotes the binding of STAT1 homodimers to the IFNgamma response region of the FcgammaRI promoter.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "circumvent") (:form . "circumvent") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . 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"activity") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 174)\n  (:start . 169) (:id . 69))\n ((:tag . "RB") (:stem . "essentially") (:form . "essentially") (:end . 186)\n  (:start . 175) (:id . 70))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "p50/rela") (:form . "p50/RelA") (:end . 207)\n  (:start . 199) (:id . 73))\n ((:tag . "NNS") (:stem . "dimer") (:form . "dimers") (:end . 214)\n  (:start . 208) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 224) (:start . 220)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 233)\n  (:start . 225) (:id . 78))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 242)\n  (:start . 234) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 80))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 254)\n  (:start . 247) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 257) (:start . 255)\n  (:id . 82))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 263)\n  (:start . 258) (:id . 83))\n ((:tag . "NNS") (:stem . "homodimer") (:form . "homodimers") (:end . 274)\n  (:start . 264) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 277) (:start . 275)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 281) (:start . 278)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 290)\n  (:start . 282) (:id . 87))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 299)\n  (:start . 291) (:id . 88))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 306)\n  (:start . 300) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 309) (:start . 307)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 313) (:start . 310)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "FcgammaRI") (:form . "FcgammaRI") (:end . 323)\n  (:start . 314) (:id . 92))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 332)\n  (:start . 324) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 333) (:start . 332)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s1200.6) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011148@unknown@formal@none@1@S@Moreover, we report that neutrophil stimulation with GM-CSF results in the formation of a STAT5-containing DNA-binding activity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GM-CSF") (:form . "GM-CSF") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "stat5-containing") (:form . "STAT5-containing")\n  (:end . 106) (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1200.7) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011150@unknown@formal@none@1@S@In addition, the procedure described herein could prove useful in other cell types that express high levels of endogenous proteases.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "RB") (:stem . "herein") (:form . "herein") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1200.9.1) (:span 44 49)))\n (:hscopes ((:id . :x1200.9.1) (:span 44 131)))\n (:identifiers (:sid . :s1200.9) (:did . :|9748323|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011151@unknown@formal@none@1@S@The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pebp2betamyh11") (:form . "PEBP2betaMYH11")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "Inv(16)(p13;q22)") (:form . "Inv(16)(p13;q22)")\n  (:end . 53) (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "VBZ") (:stem . "impair") (:form . "impairs") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 103)\n  (:start . 93) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 119)\n  (:start . 108) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 135)\n  (:start . 123) (:id . 57))\n ((:tag . "NN") (:stem . "dysplasia") (:form . "dysplasia") (:end . 145)\n  (:start . 136) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1201.1) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011152@unknown@formal@none@1@S@Chromosomal translocations involving the genes encoding the alpha and beta subunits of the Pebp2/Cbf transcription factor have been associated with human acute myeloid leukemia and the preleukemic condition, myelodysplasia.@(((:tag . "JJ") (:stem . "chromosomal") (:form . "Chromosomal") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "translocation") (:form . "translocations")\n  (:end . 26) (:start . 12) (:id . 43))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 36)\n  (:start . 27) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 55)\n  (:start . 47) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Pebp2/Cbf") (:form . "Pebp2/Cbf") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 126) (:start . 122)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 142)\n  (:start . 132) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 153)\n  (:start . 148) (:id . 62))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 159)\n  (:start . 154) (:id . 63))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 167)\n  (:start . 160) (:id . 64))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 176)\n  (:start . 168) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 180) (:start . 177)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "preleukemic") (:form . "preleukemic") (:end . 196)\n  (:start . 185) (:id . 68))\n ((:tag . "NN") (:stem . "condition") (:form . "condition") (:end . 206)\n  (:start . 197) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "myelodysplasia") (:form . "myelodysplasia")\n  (:end . 222) (:start . 208) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1201.2) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011153@unknown@formal@none@1@S@Inv(16)(p13;q22) fuses the gene encoding the beta subunit of Pebp2 to the MYH11 gene encoding a smooth muscle myosin heavy chain (Smmhc).@(((:tag . "NNP") (:stem . "Inv(16)(p13;q22)") (:form . "Inv(16)(p13;q22)")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "fuse") (:form . "fuses") (:end . 22) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "beta") (:form . "beta") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pebp2") (:form . "Pebp2") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "myh11") (:form . "MYH11") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "smooth") (:form . "smooth") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "myosin") (:form . "myosin") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "heavy") (:form . "heavy") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Smmhc") (:form . "Smmhc") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1201.3) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011154@unknown@formal@none@1@S@To examine the effect of the inv(16)(p13;q22) on myelopoiesis, we used the hMRP8 promoter element to generate transgenic mice expressing the Pebp2beta Smmhc chimeric fusion protein in myeloid cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inv(16)(p13;q22)") (:form . "inv(16)(p13;q22)")\n  (:end . 45) (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "myelopoiesis") (:form . "myelopoiesis") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hmrp8") (:form . "hMRP8") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 125)\n  (:start . 121) (:id . 61))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 136)\n  (:start . 126) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Pebp2beta") (:form . "Pebp2beta") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "NNP") (:stem . "Smmhc") (:form . "Smmhc") (:end . 156)\n  (:start . 151) (:id . 65))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 172)\n  (:start . 166) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 180)\n  (:start . 173) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 191)\n  (:start . 184) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1201.4) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011155@unknown@formal@none@1@S@Neutrophil maturation was impaired in PEBP2betaMYH11 transgenic mice.@(((:tag . "NNP") (:stem . "Neutrophil") (:form . "Neutrophil") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "impair") (:form . "impaired") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pebp2betamyh11") (:form . "PEBP2betaMYH11")\n  (:end . 52) (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1201.5) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011156@unknown@formal@none@1@S@Although the transgenic mice had normal numbers of circulating neutrophils, their bone marrow contained increased numbers of immature neutrophilic cells, which exhibited abnormal characteristics.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 81)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "marrow") (:form . "marrow") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 121)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "JJ") (:stem . "neutrophilic") (:form . "neutrophilic") (:end . 146)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 159)\n  (:start . 154) (:id . 64))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 169)\n  (:start . 160) (:id . 65))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 178)\n  (:start . 170) (:id . 66))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 194) (:start . 179) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1201.6) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011157@unknown@formal@none@1@S@In addition, PEBP2betaMYH11 inhibited neutrophilic differentiation in colonies derived from hematopoietic progenitors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PEBP2betaMYH11") (:form . "PEBP2betaMYH11")\n  (:end . 27) (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "JJ") (:stem . "neutrophilic") (:form . "neutrophilic") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 66) (:start . 51) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "colony") (:form . "colonies") (:end . 78)\n  (:start . 70) (:id . 50))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 86)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 91) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 105) (:start . 92) (:id . 53))\n ((:tag . "NNS") (:stem . "progenitor") (:form . "progenitors") (:end . 117)\n  (:start . 106) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1201.7) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011158@unknown@formal@none@1@S@Coexpression of both PEBP2betaMYH11 and activated NRAS induced a more severe phenotype characterized by abnormal nuclear morphology indicative of granulocytic dysplasia.@(((:tag . "NN") (:stem . "coexpression") (:form . "Coexpression") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pebp2betamyh11") (:form . "PEBP2betaMYH11")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "nras") (:form . "NRAS") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 100) (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 112)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 131)\n  (:start . 121) (:id . 58))\n ((:tag . "JJ") (:stem . "indicative") (:form . "indicative") (:end . 142)\n  (:start . 132) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "granulocytic") (:form . "granulocytic") (:end . 158)\n  (:start . 146) (:id . 61))\n ((:tag . "NN") (:stem . "dysplasia") (:form . "dysplasia") (:end . 168)\n  (:start . 159) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1201.8) (:did . :|9751756|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011160@unknown@formal@none@1@S@Transcription factor activation in lymphokine activated killer cells and lymphocytes from patients receiving IL-2 immunotherapy.@(((:tag . "NNP") (:stem . "Transcription") (:form . "Transcription")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lymphokine") (:form . "lymphokine") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "JJ") (:stem . "activated") (:form . "activated") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 62)\n  (:start . 56) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 84)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "VBG") (:stem . "receive") (:form . "receiving") (:end . 108)\n  (:start . 99) (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 113) (:start . 109)\n  (:id . 55))\n ((:tag . "NN") (:stem . "immunotherapy") (:form . "immunotherapy")\n  (:end . 127) (:start . 114) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1202.1) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011161@unknown@formal@none@1@S@Administration of the cytokine interleukin-2 (IL-2) can result in therapeutic benefits for individuals with renal cell carcinoma and melanoma.@(((:tag . "NNP") (:stem . "Administration") (:form . "Administration")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 44) (:start . 31) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "therapeutic") (:form . "therapeutic") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "benefit") (:form . "benefits") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "melanoma") (:form . "melanoma") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1202.2) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011162@unknown@formal@none@1@S@Here we report an analysis of the transcription factor families AP-1, Sp1, NF-kappaB, and signal transducers and activators of transcription (STAT) in cancer patients' lymphocytes before and after IL-2 immunotherapy, as assessed by a gel-shift assay.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "NNS") (:stem . "transducer") (:form . "transducers") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 140) (:start . 127) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "POS") (:stem . "'") (:form . "'") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 179)\n  (:start . 168) (:id . 72))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 186)\n  (:start . 180) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 196)\n  (:start . 191) (:id . 75))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . "NN") (:stem . "immunotherapy") (:form . "immunotherapy")\n  (:end . 215) (:start . 202) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 219) (:start . 217)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 228)\n  (:start . 220) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 231) (:start . 229)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 233) (:start . 232)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "gel-shift") (:form . "gel-shift") (:end . 243)\n  (:start . 234) (:id . 83))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 249)\n  (:start . 244) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1202.3) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011163@unknown@formal@none@1@S@An in vitro surrogate of IL-2 immunotherapy is the incubation of fresh peripheral blood mononuclear cells (PBMC) from healthy individuals in IL-2 for several days, resulting in the production of lymphokine-activated killer (LAK) activity in these cultures.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "surrogate") (:form . "surrogate") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunotherapy") (:form . "immunotherapy")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 81)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "day") (:form . "days") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 173)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 72))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 191)\n  (:start . 181) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "lymphokine-activated")\n  (:form . "lymphokine-activated") (:end . 215) (:start . 195) (:id . 75))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 222)\n  (:start . 216) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 224) (:start . 223)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 227) (:start . 224)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 79))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 237)\n  (:start . 229) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 81))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 246)\n  (:start . 241) (:id . 82))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 255)\n  (:start . 247) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 256) (:start . 255)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1202.4) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011164@unknown@formal@none@1@S@One purpose of this study was to describe the profile of transcription factor activation in these different populations, and assess whether the patterns observed correlated with functional differences in these cells.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "describe") (:form . "describe") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 161)\n  (:start . 153) (:id . 66))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 188)\n  (:start . 178) (:id . 69))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 200)\n  (:start . 189) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 71))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 209)\n  (:start . 204) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 215)\n  (:start . 210) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1202.5.1) (:span 132 139)))\n (:hscopes ((:id . :x1202.5.1) (:span 132 215)))\n (:identifiers (:sid . :s1202.5) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011165@unknown@formal@none@1@S@Prior to in vivo IL-2 administration, the typical binding pattern of transcription factors in PBMC from patients resembled that seen in fresh PBMC from healthy individuals.@(((:tag . "RB") (:stem . "prior") (:form . "Prior") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "administration") (:form . "administration")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 82) (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "VBD") (:stem . "resemble") (:form . "resembled") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 171)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1202.6) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011166@unknown@formal@none@1@S@Over a 3-week course of IL-2 therapy, in most patients the binding patterns of AP-1 , Sp1, and NF-kappaB proteins changed to resemble those seen in PBMC activated by IL-2 in vitro.@(((:tag . "IN") (:stem . "over") (:form . "Over") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "3-week") (:form . "3-week") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 104)\n  (:start . 95) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 113)\n  (:start . 105) (:id . 63))\n ((:tag . "VBD") (:stem . "change") (:form . "changed") (:end . 121)\n  (:start . 114) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "VB") (:stem . "resemble") (:form . "resemble") (:end . 133)\n  (:start . 125) (:id . 66))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 144) (:start . 140)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 152) (:start . 148)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 162)\n  (:start . 153) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 74))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 179)\n  (:start . 174) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1202.7) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011167@unknown@formal@none@1@S@However, the cells obtained from IL-2-treated patients did not have low-level constitutive expression of STAT binding factors as did LAK cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "il-2-treated") (:form . "IL-2-treated") (:end . 45)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "low-level") (:form . "low-level") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "LAK") (:form . "LAK") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1202.8.1) (:span 59 62)))\n (:nscopes ((:id . :x1202.8.1) (:span 59 125)))\n (:identifiers (:sid . :s1202.8) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011168@unknown@formal@none@1@S@When these patient cells were further stimulated by IL-2 in vitro, additional differences in STAT induction patterns were noted.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "patient") (:form . "patient") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1202.9) (:did . :|9756417|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011170@unknown@formal@none@1@S@A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p75") (:form . "p75") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "p75TNF-R") (:form . "p75TNF-R") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 90)\n  (:start . 78) (:id . 57))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lymphotoxin") (:form . "lymphotoxin") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "p55TNF-R") (:form . "p55TNF-R") (:end . 145)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1203.1) (:did . :|9763613|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011171@unknown@formal@none@1@S@Despite overwhelming evidence that enhanced production of the p75 tumor necrosis factor receptor (p75TNF-R) accompanies development of specific human inflammatory pathologies such as multi-organ failure during sepsis, inflammatory liver disease, pancreatitis, respiratory distress syndrome, or AIDS, the function of this receptor remains poorly defined in vivo.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "overwhelming") (:form . "overwhelming") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 29)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . 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",") (:end . 259) (:start . 258)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 271)\n  (:start . 260) (:id . 78))\n ((:tag . "NN") (:stem . "distress") (:form . "distress") (:end . 280)\n  (:start . 272) (:id . 79))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 289)\n  (:start . 281) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 290) (:start . 289)\n  (:id . 81))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 293) (:start . 291)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "AIDS") (:form . "AIDS") (:end . 298) (:start . 294)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 299) (:start . 298)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 303) (:start . 300)\n  (:id . 85))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 312)\n  (:start . 304) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 315) (:start . 313)\n  (:id . 87))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 320) (:start . 316)\n  (:id . 88))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 329)\n  (:start . 321) (:id . 89))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 337)\n  (:start . 330) (:id . 90))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 344)\n  (:start . 338) (:id . 91))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 352)\n  (:start . 345) (:id . 92))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 355) (:start . 353)\n  (:id . 93))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 360) (:start . 356)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 361) (:start . 360)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s1203.2) (:did . :|9763613|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011172@unknown@formal@none@1@S@We show here that at levels relevant to human disease, production of the human p75TNF-R in transgenic mice results in a severe inflammatory syndrome involving mainly the pancreas, liver, kidney, and lung, and characterized by constitutively increased NF-kappaB activity in the peripheral blood mononuclear cell compartment.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "relevant") (:form . 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"blood") (:form . "blood") (:end . 293)\n  (:start . 288) (:id . 89))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 305)\n  (:start . 294) (:id . 90))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 310) (:start . 306)\n  (:id . 91))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 322)\n  (:start . 311) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 323) (:start . 322)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s1203.3) (:did . :|9763613|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011173@unknown@formal@none@1@S@This process is shown to evolve independently of the presence of TNF, lymphotoxin alpha, or the p55TNF-R, although coexpression of a human TNF transgene accelerated pathology.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VB") (:stem . "evolve") (:form . "evolve") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lymphotoxin") (:form . "lymphotoxin") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "p55TNF-R") (:form . "p55TNF-R") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "coexpression") (:form . "coexpression") (:end . 127)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 138)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "tnf") (:form . "TNF") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 152)\n  (:start . 143) (:id . 68))\n ((:tag . "VBD") (:stem . "accelerate") (:form . "accelerated") (:end . 164)\n  (:start . 153) (:id . 69))\n ((:tag . "NN") (:stem . "pathology") (:form . "pathology") (:end . 174)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1203.4) (:did . :|9763613|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011174@unknown@formal@none@1@S@These results establish an independent role for enhanced p75TNF-R production in the pathogenesis of inflammatory disease and implicate the direct involvement of this receptor in a wide range of human inflammatory pathologies.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "establish") (:form . "establish") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "p75TNF-R") (:form . "p75TNF-R") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 96)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 112)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "implicate") (:form . "implicate") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 145)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 157)\n  (:start . 146) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 174)\n  (:start . 166) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 179) (:start . 178)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 184) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 190)\n  (:start . 185) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 199)\n  (:start . 194) (:id . 71))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 212)\n  (:start . 200) (:id . 72))\n ((:tag . "NNS") (:stem . "pathology") (:form . "pathologies") (:end . 224)\n  (:start . 213) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1203.5) (:did . :|9763613|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011175@unknown@formal@none@1@S@Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells.@(((:tag . "JJ") (:stem . "potent") (:form . "Potent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 66) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "alkaloid") (:form . "alkaloid") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cepharanthine") (:form . "cepharanthine")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 106)\n  (:start . 95) (:id . 57))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1204.1) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011176@unknown@formal@none@1@S@Cepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata and has been shown to have antiinflammatory, antiallergic, and immunomodulatory activities in vivo.@(((:tag . "NNP") (:stem . "Cepharanthine") (:form . "Cepharanthine")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "biscoclaurine") (:form . "biscoclaurine")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "alkaloid") (:form . "alkaloid") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Stephania") (:form . "Stephania") (:end . 65)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "cepharantha") (:form . "cepharantha") (:end . 77)\n  (:start . 66) (:id . 50))\n ((:tag . "NNP") (:stem . "Hayata") (:form . "Hayata") (:end . 84)\n  (:start . 78) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 92) (:start . 89)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "antiinflammatory") (:form . "antiinflammatory")\n  (:end . 128) (:start . 112) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "antiallergic") (:form . "antiallergic") (:end . 142)\n  (:start . 130) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 164) (:start . 148) (:id . 63))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 175)\n  (:start . 165) (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 183) (:start . 179)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1204.2) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011177@unknown@formal@none@1@S@As several inflammatory cytokines and oxidative stresses are involved in the pathogenesis of HIV-1 infection, we investigated the inhibitory effects of cepharanthine on tumor necrosis factor alpha (TNF-alpha)- and phorbol 12-myristate 13-acetate (PMA)-induced HIV-1 replication in chronically infected cell lines.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "oxidative") (:form . "oxidative") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "stress") (:form . "stresses") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 98) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 108)\n  (:start . 99) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 125)\n  (:start . 113) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "cepharanthine") (:form . "cepharanthine")\n  (:end . 165) (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 174)\n  (:start . 169) (:id . 66))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 190)\n  (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 196)\n  (:start . 191) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "TNF-alpha)-") (:form . "TNF-alpha)-") (:end . 209)\n  (:start . 198) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 72))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 221)\n  (:start . 214) (:id . 73))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 234)\n  (:start . 222) (:id . 74))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 245)\n  (:start . 235) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 247) (:start . 246)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PMA)-induced") (:form . "PMA)-induced")\n  (:end . 259) (:start . 247) (:id . 77))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 265)\n  (:start . 260) (:id . 78))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 277)\n  (:start . 266) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 280) (:start . 278)\n  (:id . 80))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 292)\n  (:start . 281) (:id . 81))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 301)\n  (:start . 293) (:id . 82))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 306) (:start . 302)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 312)\n  (:start . 307) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 313) (:start . 312)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1204.3) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011178@unknown@formal@none@1@S@Two chronically HIV-1-infected cell lines, U1 (monocytic) and ACH-2 (T lymphocytic), were stimulated with TNF-alpha or PMA and cultured in the presence of various concentrations of the compound.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 30) (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "lymphocytic") (:form . "lymphocytic") (:end . 82)\n  (:start . 71) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 100)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 115)\n  (:start . 106) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 151)\n  (:start . 143) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 162)\n  (:start . 155) (:id . 71))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 177) (:start . 163) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 74))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 193)\n  (:start . 185) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1204.4) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011180@unknown@formal@none@1@S@The inhibitory effects of cepharanthine on HIV-1 long terminal repeat (LTR)-driven gene expression and nuclear factor kappaB (NF-kappaB) activation were also examined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cepharanthine") (:form . "cepharanthine")\n  (:end . 39) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LTR)-driven") (:form . "LTR)-driven") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 147)\n  (:start . 137) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 157) (:start . 153)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1204.6) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011181@unknown@formal@none@1@S@Cepharanthine dose dependently inhibited HIV-1 replication in TNF-alpha- and PMA-stimulated U1 cells but not in ACH-2 cells.@(((:tag . "NNP") (:stem . "Cepharanthine") (:form . "Cepharanthine")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dose") (:form . "dose") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "RB") (:stem . "dependently") (:form . "dependently") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 46) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 58)\n  (:start . 47) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tnf-alpha-") (:form . "TNF-alpha-") (:end . 72)\n  (:start . 62) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pma-stimulated") (:form . "PMA-stimulated")\n  (:end . 91) (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ach-2") (:form . "ACH-2") (:end . 117)\n  (:start . 112) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1204.7.1) (:span 105 108)))\n (:nscopes ((:id . :x1204.7.1) (:span 105 123)))\n (:identifiers (:sid . :s1204.7) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011182@unknown@formal@none@1@S@Its 50% effective and cytotoxic concentrations were 0.016 and 2.2 microg/ml in PMA-stimulated U1 cells, respectively.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 17)\n  (:start . 8) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 46) (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.016") (:form . "0.016") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2.2") (:form . "2.2") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "microg/ml") (:form . "microg/ml") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pma-stimulated") (:form . "PMA-stimulated")\n  (:end . 93) (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 116)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1204.8) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011183@unknown@formal@none@1@S@Cepharanthine was found to suppress HIV-1 LTR-driven gene expression through the inhibition of NF-kappaB activation.@(((:tag . "NNP") (:stem . "Cepharanthine") (:form . "Cepharanthine")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ltr-driven") (:form . "LTR-driven") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1204.9) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011184@unknown@formal@none@1@S@These results indicate that cepharanthine is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cepharanthine") (:form . "cepharanthine")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "RB") (:stem . "chronically") (:form . "chronically") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 132) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 137) (:start . 133)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1204.10.1) (:span 14 27)))\n (:hscopes ((:id . :x1204.10.1) (:span 14 137)))\n (:identifiers (:sid . :s1204.10) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011185@unknown@formal@none@1@S@Since biscoclaurine alkaloids, containing cepharanthine as a major component, are widely used for the treatment of patients with various inflammatory diseases in Japan, cepharanthine should be further pursued for its chemotherapeutic potential in HIV-1-infected patients.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "biscoclaurine") (:form . "biscoclaurine")\n  (:end . 19) (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "alkaloid") (:form . "alkaloids") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "cepharanthine") (:form . "cepharanthine")\n  (:end . 55) (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Japan") (:form . "Japan") (:end . 167)\n  (:start . 162) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cepharanthine") (:form . "cepharanthine")\n  (:end . 182) (:start . 169) (:id . 68))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 189)\n  (:start . 183) (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 200)\n  (:start . 193) (:id . 71))\n ((:tag . "VBN") (:stem . "pursue") (:form . "pursued") (:end . 208)\n  (:start . 201) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 212) (:start . 209)\n  (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "chemotherapeutic") (:form . "chemotherapeutic")\n  (:end . 233) (:start . 217) (:id . 75))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 243)\n  (:start . 234) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 246) (:start . 244)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "hiv-1-infected") (:form . "HIV-1-infected")\n  (:end . 261) (:start . 247) (:id . 78))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 270)\n  (:start . 262) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1204.11.1) (:span 183 189)))\n (:hscopes ((:id . :x1204.11.1) (:span 169 270)))\n (:identifiers (:sid . :s1204.11) (:did . :|9764907|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011186@unknown@formal@none@1@S@Prostaglandin E2 Up-regulates HIV-1 long terminal repeat-driven gene activity in T cells via NF-kappaB-dependent and -independent signaling pathways.@(((:tag . "NN") (:stem . "prostaglandin") (:form . "Prostaglandin")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "E2") (:form . "E2") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "Up-regulates") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "JJ") (:stem . "repeat-driven") (:form . "repeat-driven")\n  (:end . 63) (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 112) (:start . 93) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 129)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 139)\n  (:start . 130) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 148)\n  (:start . 140) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1205.1) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011187@unknown@formal@none@1@S@Replication of human immunodeficiency virus type-1 (HIV-1) is highly dependent on the state of activation of the infected cells and is modulated by interactions between viral and host cellular factors.@(((:tag . "NNP") (:stem . "Replication") (:form . "Replication") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 37) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "type-1") (:form . "type-1") (:end . 50)\n  (:start . 44) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "modulate") (:form . "modulated") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 160)\n  (:start . 148) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 168)\n  (:start . 161) (:id . 68))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 174)\n  (:start . 169) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 192)\n  (:start . 184) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 200)\n  (:start . 193) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1205.2) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011188@unknown@formal@none@1@S@Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, is observed at elevated levels during HIV-1 infection as well as during the course of other pathogenic infections.@(((:tag . "NN") (:stem . "prostaglandin") (:form . "Prostaglandin")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "e2") (:form . "E2") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pleiotropic") (:form . "pleiotropic") (:end . 38)\n  (:start . 27) (:id . 49))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 55) (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 168)\n  (:start . 158) (:id . 69))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1205.3) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011190@unknown@formal@none@1@S@Experiments have been conducted to identify second messengers involved in this PGE2-dependent up-regulating effect on the regulatory element of HIV-1.@(((:tag . "NNS") (:stem . "experiment") (:form . "Experiments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "messenger") (:form . "messengers") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pge2-dependent") (:form . "PGE2-dependent")\n  (:end . 93) (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "up-regulating") (:form . "up-regulating")\n  (:end . 107) (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 114)\n  (:start . 108) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 132)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 140)\n  (:start . 133) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1205.5) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011191@unknown@formal@none@1@S@In this study, we present evidence indicating that signal transduction pathways induced by PGE2 necessitate the participation of cyclic AMP, protein kinase A, and Ca2+.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 45)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "necessitate") (:form . "necessitate") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "participation") (:form . "participation")\n  (:end . 125) (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Ca2+") (:form . "Ca2+") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1205.6.1) (:span 35 50)))\n (:hscopes ((:id . :x1205.6.1) (:span 35 167)))\n (:identifiers (:sid . :s1205.6) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011192@unknown@formal@none@1@S@Experiments conducted with different HIV-1 LTR-based vectors suggested that PGE2-mediated activation effect on HIV-1 transcription was transduced via both NF-kappaB-dependent and -independent signaling pathways.@(((:tag . "NNS") (:stem . "experiment") (:form . "Experiments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "conduct") (:form . "conducted") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ltr-based") (:form . "LTR-based") (:end . 52)\n  (:start . 43) (:id . 47))\n ((:tag . "NNS") (:stem . "vector") (:form . "vectors") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pge2-mediated") (:form . "PGE2-mediated")\n  (:end . 89) (:start . 76) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 107)\n  (:start . 101) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 110) (:start . 108)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 116)\n  (:start . 111) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 130) (:start . 117) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 134) (:start . 131)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 145)\n  (:start . 135) (:id . 58))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 149) (:start . 146)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 154) (:start . 150)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 174) (:start . 155) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 191)\n  (:start . 179) (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 201)\n  (:start . 192) (:id . 64))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 210)\n  (:start . 202) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1205.7.1) (:span 61 70)))\n (:hscopes ((:id . :x1205.7.1) (:span 61 210)))\n (:identifiers (:sid . :s1205.7) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011193@unknown@formal@none@1@S@The involvement of NF-kappaB in the PGE2-dependent activating effect on HIV-1 transcription was further confirmed using a kappaB-regulated luciferase encoding vector and by electrophoretic mobility shift assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pge2-dependent") (:form . "PGE2-dependent")\n  (:end . 50) (:start . 36) (:id . 48))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 68)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 119) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "kappab-regulated") (:form . "kappaB-regulated")\n  (:end . 138) (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 149)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "encoding") (:form . "encoding") (:end . 158)\n  (:start . 150) (:id . 61))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 165)\n  (:start . 159) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 188) (:start . 173) (:id . 65))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 197)\n  (:start . 189) (:id . 66))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 203)\n  (:start . 198) (:id . 67))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 210)\n  (:start . 204) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1205.8) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011194@unknown@formal@none@1@S@Results from Northern blot and flow cytometric analyses, as well as the use of a selective antagonist indicated that PGE2 modulation of HIV-1 LTR-driven reporter gene activity in studied T lymphoid cells is transduced via the EP4 receptor subtype.@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cytometric") (:form . "cytometric") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 101)\n  (:start . 91) (:id . 59))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "ltr-driven") (:form . "LTR-driven") (:end . 152)\n  (:start . 142) (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 161)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 186)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 217)\n  (:start . 207) (:id . 76))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 221) (:start . 218)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . "NN") (:stem . "ep4") (:form . "EP4") (:end . 229) (:start . 226)\n  (:id . 79))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 238)\n  (:start . 230) (:id . 80))\n ((:tag . "NN") (:stem . "subtype") (:form . "subtype") (:end . 246)\n  (:start . 239) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1205.9.1) (:span 102 116)))\n (:hscopes ((:id . :x1205.9.1) (:span 102 246)))\n (:identifiers (:sid . :s1205.9) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011195@unknown@formal@none@1@S@These results suggest that secretion of PGE2 by macrophages in response to infection or inflammatory activators could induce signaling events resulting in activation of proviral DNA present into T cells latently infected with HIV-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 100)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "activator") (:form . "activators") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 124)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 141)\n  (:start . 135) (:id . 61))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 151)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 181) (:start . 178)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 189)\n  (:start . 182) (:id . 68))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 194) (:start . 190)\n  (:id . 69))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 196) (:start . 195)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 202)\n  (:start . 197) (:id . 71))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 211)\n  (:start . 203) (:id . 72))\n ((:tag . "VBN") (:stem . "infect") (:form . "infected") (:end . 220)\n  (:start . 212) (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 225) (:start . 221)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 231)\n  (:start . 226) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1205.10.1) (:span 112 117))\n  ((:id . :x1205.10.2) (:span 14 21)))\n (:hscopes ((:id . :x1205.10.1) (:span 112 231))\n  ((:id . :x1205.10.2) (:span 14 231)))\n (:identifiers (:sid . :s1205.10) (:did . :|9765256|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011196@unknown@formal@none@1@S@Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras.@(((:tag . "NNP") (:stem . "Fcgamma") (:form . "Fcgamma") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "receptor-mediated") (:form . "receptor-mediated")\n  (:end . 25) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 43) (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 51)\n  (:start . 44) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 58)\n  (:start . 52) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 97)\n  (:start . 86) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 104) (:start . 101)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1206.1) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011197@unknown@formal@none@1@S@Receptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cellular responses that are very important in host defense, including phagocytosis, cell cytotoxicity, production and secretion of inflammatory mediators, and modulation of the immune response.@(((:tag . "NNS") (:stem . "receptor") (:form . "Receptors") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunoglobulin") (:form . 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5011198@unknown@formal@none@1@S@Cross-linking of FcR with immune complexes leads, first to activation of protein-tyrosine kinases.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fcr") (:form . "FcR") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "protein-tyrosine") (:form . "protein-tyrosine")\n  (:end . 89) (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1206.3) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011200@unknown@formal@none@1@S@We have investigated the signal transduction pathway from Fc receptors that leads to gene activation and production of cytokines in monocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fc") (:form . "Fc") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 115)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 141)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1206.5) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011201@unknown@formal@none@1@S@Cross-linking of FcR, on the THP-1 monocytic cell line, by immune complexes resulted in both activation of the transcription factor NF-kappaB and interleukin 1 production.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "FcR") (:form . "FcR") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 124) (:start . 111) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 157)\n  (:start . 146) (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 170)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1206.6) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011202@unknown@formal@none@1@S@These responses were completely blocked by tyrosine kinase inhibitors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1206.7) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011203@unknown@formal@none@1@S@In contrast, expression of dominant negative mutants of Ras and Raf-1, in these cells, did not have any effect on FcR-mediated nuclear factor activation, suggesting that the mitogen-activated protein kinase (MAPK) signaling pathway was not used by these receptors.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . 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"not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 99) (:start . 95)\n  (:id . 61))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 103) (:start . 100)\n  (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 110)\n  (:start . 104) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "fcr-mediated") (:form . "FcR-mediated") (:end . 126)\n  (:start . 114) (:id . 65))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 134)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 141)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 152)\n  (:start . 142) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 164)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 191) (:start . 174) (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 199)\n  (:start . 192) (:id . 74))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 206)\n  (:start . 200) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 208) (:start . 207)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 212) (:start . 208)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 78))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 223)\n  (:start . 214) (:id . 79))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 231)\n  (:start . 224) (:id . 80))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 235) (:start . 232)\n  (:id . 81))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 239) (:start . 236)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 244) (:start . 240)\n  (:id . 83))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 247) (:start . 245)\n  (:id . 84))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 253)\n  (:start . 248) (:id . 85))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 263)\n  (:start . 254) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") 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5011204@unknown@formal@none@1@S@However, MAPK activation was easily detected by in vitro kinase assays, after FcR cross-linking with immune complexes.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "easily") (:form . "easily") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "FcR") (:form . "FcR") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 95) (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1206.9) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011205@unknown@formal@none@1@S@Using the specific MAPK/extracellular signal-regulated kinase kinase (MAPK kinase) inhibitor PD98059, we found that MAPK activation is necessary for FcR-dependent activation of the nuclear factor NF-kappaB.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "mapk/extracellular") (:form . "MAPK/extracellular")\n  (:end . 37) (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "signal-regulated") (:form . "signal-regulated")\n  (:end . 54) (:start . 38) (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 61)\n  (:start . 55) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 68)\n  (:start . 62) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 74) (:start . 70)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "pd98059") (:form . "PD98059") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "fcr-dependent") (:form . "FcR-dependent")\n  (:end . 162) (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 188)\n  (:start . 181) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 195)\n  (:start . 189) (:id . 69))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 205)\n  (:start . 196) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1206.10) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011206@unknown@formal@none@1@S@These results strongly suggest that the signaling pathway from Fc receptors leading to expression of different genes important to leukocyte biology, initiates with tyrosine kinases and requires MAPK activation; but in contrast to other tyrosine kinase receptors, FcR-mediated MAPK activation does not involve Ras and Raf.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . 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"and") (:end . 184) (:start . 181)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 193)\n  (:start . 185) (:id . 69))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 198) (:start . 194)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 209)\n  (:start . 199) (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 210) (:start . 209)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 226)\n  (:start . 218) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 229) (:start . 227)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 235)\n  (:start . 230) (:id . 77))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 244)\n  (:start . 236) (:id . 78))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 251)\n  (:start . 245) (:id . 79))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 261)\n  (:start . 252) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 262) (:start . 261)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "fcr-mediated") (:form . "FcR-mediated") (:end . 275)\n  (:start . 263) (:id . 82))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 280) (:start . 276)\n  (:id . 83))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 291)\n  (:start . 281) (:id . 84))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 296) (:start . 292)\n  (:id . 85))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 300) (:start . 297)\n  (:id . 86))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 308)\n  (:start . 301) (:id . 87))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 312) (:start . 309)\n  (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 316) (:start . 313)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "Raf") (:form . "Raf") (:end . 320) (:start . 317)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 321) (:start . 320)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x1206.11.2) (:span 23 30)))\n (:ncues ((:id . :x1206.11.1) (:span 297 300)))\n (:hscopes ((:id . :x1206.11.2) (:span 23 320)))\n (:nscopes ((:id . :x1206.11.1) (:span 297 320)))\n (:identifiers (:sid . :s1206.11) (:did . :|9765295|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011207@unknown@formal@none@1@S@Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "display") (:form . "display") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 58)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 73)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 81)\n  (:start . 74) (:id . 51))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1207.1) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011208@unknown@formal@none@1@S@To characterize further the function of the intracellular vitamin D receptor (VDR), we have developed stable transfectant variants of a vitamin D-responsive cell line (U937) which express either decreased or increased numbers of VDR.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "transfectant") (:form . "transfectant") (:end . 121)\n  (:start . 109) (:id . 61))\n ((:tag . "NNS") (:stem . "variant") (:form . "variants") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "vitamin") (:form . "vitamin") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "d-responsive") (:form . "D-responsive") (:end . 156)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 187)\n  (:start . 180) (:id . 73))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 194)\n  (:start . 188) (:id . 74))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 204)\n  (:start . 195) (:id . 75))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 207) (:start . 205)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 217)\n  (:start . 208) (:id . 77))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 225)\n  (:start . 218) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 228) (:start . 226)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 232) (:start . 229)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1207.2) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011210@unknown@formal@none@1@S@Initial experiments indicated that a 50% decrease in VDR levels was associated with a 2-fold increase in cell proliferation and a similar rise in c-myc mRNA expression.@(((:tag . "JJ") (:stem . "initial") (:form . "Initial") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "2-fold") (:form . "2-fold") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 123) (:start . 110) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "rise") (:form . "rise") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "c-myc") (:form . "c-myc") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 167)\n  (:start . 157) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1207.4.1) (:span 20 34)))\n (:hscopes ((:id . :x1207.4.1) (:span 20 167)))\n (:identifiers (:sid . :s1207.4) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011211@unknown@formal@none@1@S@Further studies were carried out using differential RNA display (DD).@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "display") (:form . "display") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DD") (:form . "DD") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1207.5) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011212@unknown@formal@none@1@S@Sequence analysis of DD products revealed two cDNAs with identity to known gene products: the catalytic sub-unit of DNA-protein kinase (DNA-PK(CS)), and the peroxisomal enzyme 17beta-hydroxysteroid dehydrogenase type IV (17beta-HSD IV).@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DD") (:form . "DD") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "sub-unit") (:form . "sub-unit") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA-PK(CS))") (:form . "DNA-PK(CS))") (:end . 147)\n  (:start . 136) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "peroxisomal") (:form . "peroxisomal") (:end . 168)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "17beta-hydroxysteroid")\n  (:form . "17beta-hydroxysteroid") (:end . 197) (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 211) (:start . 198) (:id . 71))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 216) (:start . 212)\n  (:id . 72))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 219) (:start . 217)\n  (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 221) (:start . 220)\n  (:id . 74))\n ((:tag . "NN") (:stem . "17beta-hsd") (:form . "17beta-HSD") (:end . 231)\n  (:start . 221) (:id . 75))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 234) (:start . 232)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 235) (:start . 234)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1207.6) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011213@unknown@formal@none@1@S@Northern analysis confirmed that expression of both mRNAs was reduced in cells with decreased numbers of VDR.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1207.7) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011214@unknown@formal@none@1@S@Down-regulation of 17beta-HSD IV mRNA expression was associated with enhanced estradiol inactivation by U937 cells, suggesting a link between estrogenic pathways and cell proliferation.@(((:tag . "NN") (:stem . "down-regulation") (:form . "Down-regulation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "NN") (:stem . "17beta-hsd") (:form . "17beta-HSD") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 77)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "estradiol") (:form . "estradiol") (:end . 87)\n  (:start . 78) (:id . 52))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 100)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 108) (:start . 104)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 141)\n  (:start . 134) (:id . 61))\n ((:tag . "JJ") (:stem . "estrogenic") (:form . "estrogenic") (:end . 152)\n  (:start . 142) (:id . 62))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 161)\n  (:start . 153) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 184) (:start . 171) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1207.8.1) (:span 116 126)))\n (:hscopes ((:id . :x1207.8.1) (:span 116 184)))\n (:identifiers (:sid . :s1207.8) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011215@unknown@formal@none@1@S@Further Northern analyses indicated that there was no significant change in 17beta-HSD IV or DNA-PK(CS) mRNA levels following treatment with 1,25(OH)2D3, although expression of both genes varied with changes in cell proliferation.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "17beta-hsd") (:form . "17beta-HSD") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DNA-PK(CS)") (:form . "DNA-PK(CS)") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 115)\n  (:start . 109) (:id . 58))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 125)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 140) (:start . 136)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "1,25(OH)2D3") (:form . "1,25(OH)2D3") (:end . 152)\n  (:start . 141) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 63))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 66))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 181) (:start . 177)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 187)\n  (:start . 182) (:id . 68))\n ((:tag . "VBD") (:stem . "vary") (:form . "varied") (:end . 194)\n  (:start . 188) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 207)\n  (:start . 200) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 215) (:start . 211)\n  (:id . 73))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 229) (:start . 216) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1207.9.2) (:span 26 40)))\n (:ncues ((:id . :x1207.9.1) (:span 51 53)))\n (:hscopes ((:id . :x1207.9.2) (:span 26 229)))\n (:nscopes ((:id . :x1207.9.1) (:span 51 152)))\n (:identifiers (:sid . :s1207.9) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011216@unknown@formal@none@1@S@These data suggest that, in addition to its established role as a hormone-dependent trans-activator, VDR may influence gene expression by ligand-independent mechanisms.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "established") (:form . "established") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "hormone-dependent") (:form . "hormone-dependent")\n  (:end . 83) (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "trans-activator") (:form . "trans-activator")\n  (:end . 99) (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "VDR") (:form . "VDR") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "ligand-independent") (:form . "ligand-independent")\n  (:end . 156) (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 167)\n  (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1207.10.1) (:span 105 108))\n  ((:id . :x1207.10.2) (:span 11 18)))\n (:hscopes ((:id . :x1207.10.1) (:span 105 167))\n  ((:id . :x1207.10.2) (:span 11 167)))\n (:identifiers (:sid . :s1207.10) (:did . :|9783909|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011217@unknown@formal@none@1@S@Downstream activation of a TATA-less promoter by Oct-2, Bob1, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells.@(((:tag . "JJ") (:stem . "downstream") (:form . "Downstream") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "tata-less") (:form . "TATA-less") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Bob1") (:form . "Bob1") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "homing") (:form . "homing") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "blr1") (:form . "BLR1") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1208.1) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011218@unknown@formal@none@1@S@The chemokine receptor, BLR1, is a major regulator of the microenvironmental homing of B cells in lymphoid organs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "chemokine") (:form . "chemokine") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BLR1") (:form . "BLR1") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 50)\n  (:start . 41) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "microenvironmental") (:form . "microenvironmental")\n  (:end . 76) (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "homing") (:form . "homing") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1208.2) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011220@unknown@formal@none@1@S@The importance of these sites was confirmed by in vivo studies in gene-targeted mice deficient of either Oct-2, Bob1, or both NF-kappaB subunits p50 and p52.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "gene-targeted") (:form . "gene-targeted")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Bob1") (:form . "Bob1") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 135)\n  (:start . 126) (:id . 65))\n ((:tag . "NNS") (:stem . "subunit") (:form . "subunits") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p52") (:form . "p52") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1208.4) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011221@unknown@formal@none@1@S@In all of these animals, the expression of BLR1 was reduced or absent.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 39)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BLR1") (:form . "BLR1") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 59)\n  (:start . 52) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1208.5.1) (:span 63 69)))\n (:nscopes ((:id . :x1208.5.1) (:span 63 69)))\n (:identifiers (:sid . :s1208.5) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011222@unknown@formal@none@1@S@In mice deficient only of p52/NF-kappaB, BLR1 expression was unaffected.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "p52/NF-kappaB") (:form . "p52/NF-kappaB")\n  (:end . 39) (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "blr1") (:form . "BLR1") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1208.6) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011223@unknown@formal@none@1@S@Thus our data demonstrate that BLR1 is a target gene for Oct-2, Bob1, and members of the NF-kappaB/Rel family and provides a link to the impaired B cell functions in mice deficient for these factors.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blr1") (:form . "BLR1") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "oct-2") (:form . "Oct-2") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Bob1") (:form . "Bob1") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 81)\n  (:start . 74) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 102) (:start . 89) (:id . 61))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 109)\n  (:start . 103) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 145)\n  (:start . 137) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 152) (:start . 148)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 162)\n  (:start . 153) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 170)\n  (:start . 166) (:id . 74))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 180)\n  (:start . 171) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 184) (:start . 181)\n  (:id . 76))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 190)\n  (:start . 185) (:id . 77))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 198)\n  (:start . 191) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1208.7) (:did . :|9786883|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011224@unknown@formal@none@1@S@Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [see comments]@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "comment") (:form . "comments") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 108) (:start . 107)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1209.1) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011225@unknown@formal@none@1@S@Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes.@(((:tag . "JJ") (:stem . "sequence-specific") (:form . "Sequence-specific")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 29)\n  (:start . 18) (:id . 43))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 35) (:start . 30)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 45)\n  (:start . 36) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "VB") (:stem . "permeate") (:form . "permeate") (:end . 63)\n  (:start . 55) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 75) (:start . 70)\n  (:id . 50))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 87)\n  (:start . 76) (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 93) (:start . 88)\n  (:id . 52))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 102)\n  (:start . 94) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 128)\n  (:start . 120) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 134)\n  (:start . 129) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1209.2.1) (:span 88 93))\n  ((:id . :x1209.2.2) (:span 76 87)))\n (:hscopes ((:id . :x1209.2.1) (:span 88 134))\n  ((:id . :x1209.2.2) (:span 76 134)))\n (:identifiers (:sid . :s1209.2) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011226@unknown@formal@none@1@S@Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 45))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 64)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 76) (:start . 72)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1209.3) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011227@unknown@formal@none@1@S@Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adjacent to binding sites for the transcription factors Ets-1, lymphoid-enhancer binding factor 1, and TATA-box binding protein.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pyrrole-imidazole") (:form . "pyrrole-imidazole")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "polyamide") (:form . "polyamides") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 46)\n  (:start . 38) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 136)\n  (:start . 129) (:id . 59))\n ((:tag . "NN") (:stem . "ets-1") (:form . "Ets-1") (:end . 142)\n  (:start . 137) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "lymphoid-enhancer") (:form . "lymphoid-enhancer")\n  (:end . 161) (:start . 144) (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 169)\n  (:start . 162) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 176)\n  (:start . 170) (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 178) (:start . 177)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tata-box") (:form . "TATA-box") (:end . 192)\n  (:start . 184) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 200)\n  (:start . 193) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 208)\n  (:start . 201) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1209.4) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011228@unknown@formal@none@1@S@These synthetic ligands specifically inhibit DNA-binding of each transcription factor and HIV type 1 transcription in cell-free assays.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 36)\n  (:start . 24) (:id . 45))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 56)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 85)\n  (:start . 79) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cell-free") (:form . "cell-free") (:end . 127)\n  (:start . 118) (:id . 58))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1209.5) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011230@unknown@formal@none@1@S@The ability of small molecules to target predetermined DNA sequences located within RNA polymerase II promoters suggests a general approach for regulation of gene expression, as well as a mechanism for the inhibition of viral replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "target") (:form . "target") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "predetermine") (:form . "predetermined")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 139)\n  (:start . 131) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 154)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 185) (:start . 183)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 197)\n  (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 216)\n  (:start . 206) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 225)\n  (:start . 220) (:id . 77))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 237)\n  (:start . 226) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1209.7.1) (:span 112 120)))\n (:hscopes ((:id . :x1209.7.1) (:span 112 237)))\n (:identifiers (:sid . :s1209.7) (:did . :|9789010|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011231@unknown@formal@none@1@S@Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells.@(((:tag . "NN") (:stem . "relationship") (:form . "Relationship") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 46)\n  (:start . 34) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 67)\n  (:start . 59) (:id . 48))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 77)\n  (:start . 68) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 92)\n  (:start . 83) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ebv-infected") (:form . "EBV-infected") (:end . 108)\n  (:start . 96) (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 123) (:start . 109) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 129)\n  (:start . 124) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1210.1) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011232@unknown@formal@none@1@S@In order to understand the role of NF-kappaB in EBV transformation we have established stably transfected IkappaBalpha into lymphoblastoid cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 66) (:start . 52) (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 86)\n  (:start . 75) (:id . 55))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 118) (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 138) (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1210.2) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011233@unknown@formal@none@1@S@Two clones were obtained in which the loss of NF-kappaB binding activity correlated with the constitutive expression of the transgenic IkappaBalpha.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 105)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 147) (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1210.3) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011234@unknown@formal@none@1@S@Protein latency expression was determined by immunocytochemistry.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "immunocytochemistry")\n  (:form . "immunocytochemistry") (:end . 64) (:start . 45) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1210.4) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011235@unknown@formal@none@1@S@Expression of surface markers, intracytoplasmic content of cytokines cell cycle analysis after BrdU incorporation and DNA staining with propidium iodide were studied by flow cytometry.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intracytoplasmic") (:form . "intracytoplasmic")\n  (:end . 47) (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "BrdU") (:form . "BrdU") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 113) (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "NN") (:stem . "propidium") (:form . "propidium") (:end . 145)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "iodide") (:form . "iodide") (:end . 152)\n  (:start . 146) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 157) (:start . 153)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 165)\n  (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 173) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 183)\n  (:start . 174) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1210.5) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011236@unknown@formal@none@1@S@Percentage of apoptotic cells was determined by in-situ labelling of DNA strand breaks.@(((:tag . "NN") (:stem . "percentage") (:form . "Percentage") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "FW") (:stem . "in-situ") (:form . "in-situ") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "labelling") (:form . "labelling") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "break") (:form . "breaks") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1210.6) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011237@unknown@formal@none@1@S@No significative changes in EBV latency nor in cell surface marker expression was found.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significative") (:form . "significative")\n  (:end . 16) (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1210.7.1) (:span 40 43)) ((:id . :x1210.7.2) (:span 0 2)))\n (:nscopes ((:id . :x1210.7.1) (:span 40 87))\n  ((:id . :x1210.7.2) (:span 0 39)))\n (:identifiers (:sid . :s1210.7) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011238@unknown@formal@none@1@S@In contrast, intracytoplasmic TNFalpha levels were strongly reduced in transfected clones.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intracytoplasmic") (:form . "intracytoplasmic")\n  (:end . 29) (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 82)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1210.8) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011240@unknown@formal@none@1@S@This correlated with a strong reduction of BrdU incorporation after 24 h of TNFalpha treatment.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "BrdU") (:form . "BrdU") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1210.10) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011241@unknown@formal@none@1@S@No effect was seen with non transfected cells or with cells transfected with a control plasmid.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "non") (:form . "non") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 71)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1210.11.1) (:span 0 2)))\n (:nscopes ((:id . :x1210.11.1) (:span 0 94)))\n (:identifiers (:sid . :s1210.11) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011242@unknown@formal@none@1@S@Our results suggest that the TNFalpha gene could be one of the targets of NF-kappaB in EBV infected cells and that NF-kappaB protects EBV-infected cells from apoptosis induced by TNFalpha, which may favour the proliferative effect of this cytokine.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 124)\n  (:start . 115) (:id . 63))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "JJ") (:stem . "ebv-infected") (:form . "EBV-infected") (:end . 146)\n  (:start . 134) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 187)\n  (:start . 179) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "VB") (:stem . "favour") (:form . "favour") (:end . 205)\n  (:start . 199) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "proliferative") (:form . "proliferative")\n  (:end . 223) (:start . 210) (:id . 77))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 230)\n  (:start . 224) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 79))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 238) (:start . 234)\n  (:id . 80))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 247)\n  (:start . 239) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1210.12.1) (:span 195 198))\n  ((:id . :x1210.12.2) (:span 43 48)) ((:id . :x1210.12.3) (:span 12 19)))\n (:hscopes ((:id . :x1210.12.1) (:span 195 247))\n  ((:id . :x1210.12.2) (:span 43 105)) ((:id . :x1210.12.3) (:span 12 247)))\n (:identifiers (:sid . :s1210.12) (:did . :|9794238|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011243@unknown@formal@none@1@S@Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28.@(((:tag . "VBG") (:stem . "uncouple") (:form . "Uncoupling") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 31) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "hs1") (:form . "HS1") (:end . 35) (:start . 32)\n  (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 51) (:start . 36) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 64)\n  (:start . 57) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 84)\n  (:start . 75) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 86) (:start . 85)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 92) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 108) (:start . 93) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 129)\n  (:start . 123) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 131) (:start . 130)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 137)\n  (:start . 132) (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 138) (:start . 137)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 151)\n  (:start . 139) (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 161)\n  (:start . 152) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 169)\n  (:start . 162) (:id . 62))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 173) (:start . 170)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 195) (:start . 182) (:id . 66))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 205)\n  (:start . 196) (:id . 67))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 209) (:start . 206)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 218) (:start . 214)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1211.1) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011244@unknown@formal@none@1@S@CD3, CD2, and CD28 are functionally distinct receptors on T lymphocytes.@(((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "CD2") (:form . "CD2") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 18) (:start . 14)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 48))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 35)\n  (:start . 23) (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 71)\n  (:start . 60) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1211.2) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011245@unknown@formal@none@1@S@Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.@(((:tag . "NN") (:stem . "engagement") (:form . "Engagement") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 79) (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "shared") (:form . "shared") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 124)\n  (:start . 115) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 144)\n  (:start . 135) (:id . 62))\n ((:tag . "NNP") (:stem . "Vav") (:form . "Vav") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Cbl") (:form . "Cbl") (:end . 153) (:start . 150)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p85") (:form . "p85") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phosphoinositide") (:form . "phosphoinositide")\n  (:end . 175) (:start . 159) (:id . 68))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 184)\n  (:start . 176) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Src") (:form . "Src") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 204)\n  (:start . 198) (:id . 74))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 212)\n  (:start . 205) (:id . 75))\n ((:tag . "NNP") (:stem . "Lck") (:form . "Lck") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Fyn") (:form . "Fyn") (:end . 224) (:start . 221)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1211.3) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011246@unknown@formal@none@1@S@Ligation of CD3 also induces the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function.@(((:tag . "NNP") (:stem . "Ligation") (:form . "Ligation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 57) (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "HS1") (:form . "HS1") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "75-kda") (:form . "75-kDa") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "JJ") (:stem . "cell-specific") (:form . "cell-specific")\n  (:end . 102) (:start . 89) (:id . 56))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 145)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 154)\n  (:start . 146) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1211.4.1) (:span 138 145)))\n (:hscopes ((:id . :x1211.4.1) (:span 138 154)))\n (:identifiers (:sid . :s1211.4) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011247@unknown@formal@none@1@S@We have examined changes in HS1 phosphorylation after differential stimulation of CD3, CD2, and CD28 to elucidate its role in T cells and to further delineate the signaling pathways recruited by these receptors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hs1") (:form . "HS1") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 47) (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "CD2") (:form . "CD2") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 148)\n  (:start . 141) (:id . 68))\n ((:tag . "VB") (:stem . "delineate") (:form . "delineate") (:end . 158)\n  (:start . 149) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 191)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 194) (:start . 192)\n  (:id . 74))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 200)\n  (:start . 195) (:id . 75))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 210)\n  (:start . 201) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1211.5) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011248@unknown@formal@none@1@S@Unlike ligation of CD3, stimulation with anti-CD28 mAb or CHO cells expressing the CD28 ligands CD80 or CD86 did not lead to tyrosine phosphorylation of HS1 in Jurkat T cells.@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ligation") (:form . "ligation") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-cd28") (:form . "anti-CD28") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "mab") (:form . "mAb") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cho") (:form . "CHO") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NNP") (:stem . "CD80") (:form . "CD80") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CD86") (:form . "CD86") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 133)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 149) (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "hs1") (:form . "HS1") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 168) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x1211.6.1) (:span 113 116)))\n (:nscopes ((:id . :x1211.6.1) (:span 113 174)))\n (:identifiers (:sid . :s1211.6) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011250@unknown@formal@none@1@S@Costimulation through CD28 and/or CD2 did not modulate the CD3-dependent phosphorylation of HS1.@(((:tag . "NN") (:stem . "costimulation") (:form . "Costimulation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 21)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cd3-dependent") (:form . "CD3-dependent")\n  (:end . 72) (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 88) (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "HS1") (:form . "HS1") (:end . 95) (:start . 92)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1211.8.1) (:span 42 45)))\n (:nscopes ((:id . :x1211.8.1) (:span 42 95)))\n (:identifiers (:sid . :s1211.8) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011251@unknown@formal@none@1@S@In vivo studies indicated that CD3-induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD45, did not require MEK1 kinase activity, and was regulated by protein kinase C activation.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cd3-induced") (:form . "CD3-induced") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "HSI") (:form . "HSI") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 62) (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 81) (:start . 77)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "src") (:form . "Src") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "NNP") (:stem . "Lck") (:form . "Lck") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 150)\n  (:start . 139) (:id . 63))\n ((:tag . "NNP") (:stem . "CD45") (:form . "CD45") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 164) (:start . 161)\n  (:id . 67))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "mek1") (:form . "MEK1") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 212)\n  (:start . 203) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 223)\n  (:start . 216) (:id . 77))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 230)\n  (:start . 224) (:id . 78))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 232) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 243)\n  (:start . 233) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1211.9.2) (:span 16 30)))\n (:ncues ((:id . :x1211.9.1) (:span 161 164)))\n (:hscopes ((:id . :x1211.9.2) (:span 16 243)))\n (:nscopes ((:id . :x1211.9.1) (:span 161 193)))\n (:identifiers (:sid . :s1211.9) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011252@unknown@formal@none@1@S@Thus, although CD3, CD28, and CD2 activate many of the same signaling molecules, they differed in their capacity to induce the tyrosine phosphorylation of HSI.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NNP") (:stem . "CD3") (:form . "CD3") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 42)\n  (:start . 34) (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 47) (:start . 43)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 59) (:start . 55)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 69)\n  (:start . 60) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 79)\n  (:start . 70) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 85) (:start . 81)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 94)\n  (:start . 86) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 103)\n  (:start . 98) (:id . 62))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 112)\n  (:start . 104) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 122)\n  (:start . 116) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 135)\n  (:start . 127) (:id . 67))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 151) (:start . 136) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "HSI") (:form . "HSI") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1211.10) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011253@unknown@formal@none@1@S@Furthermore, activation-dependent tyrosine phosphorylation of HS1 was not required for NFAT transcriptional activation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 33) (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 42)\n  (:start . 34) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 58) (:start . 43) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HS1") (:form . "HS1") (:end . 65) (:start . 62)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 107) (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1211.11.1) (:span 70 73)))\n (:nscopes ((:id . :x1211.11.1) (:span 70 118)))\n (:identifiers (:sid . :s1211.11) (:did . :|9794375|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011254@unknown@formal@none@1@S@IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.@(((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "reconstitute") (:form . "reconstitutes")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 35)\n  (:start . 28) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "v-abl-mediated") (:form . "v-Abl-mediated")\n  (:end . 53) (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1212.1) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011255@unknown@formal@none@1@S@The mechanism by which early lymphoid cells are selectively transformed by v-Abl is currently unknown.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1212.2.1) (:span 94 101)))\n (:hscopes ((:id . :x1212.2.1) (:span 0 101)))\n (:identifiers (:sid . :s1212.2) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011256@unknown@formal@none@1@S@Previous studies have shown constitutive activation of IL-4 and IL-7 signaling pathways, as measured by activation of Janus protein kinase (JAK)1, JAK3, STAT5, and STAT6, in pre-B cells transformed by v-Abl.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Janus") (:form . "Janus") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "JAK)1") (:form . "JAK)1") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "JAK3") (:form . "JAK3") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "STAT6") (:form . "STAT6") (:end . 169)\n  (:start . 164) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 185)\n  (:start . 180) (:id . 75))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 197)\n  (:start . 186) (:id . 76))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 206)\n  (:start . 201) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1212.3) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011257@unknown@formal@none@1@S@To determine whether activation of these cytokine signaling pathways by v-Abl is important in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and IL-7 on pre-B cells transformed with a temperature-sensitive v-Abl mutant were examined.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Abelson") (:form . "Abelson") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 171)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 179) (:start . 175)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 197)\n  (:start . 192) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 75))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 215)\n  (:start . 204) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 220) (:start . 216)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 222) (:start . 221)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "temperature-sensitive")\n  (:form . "temperature-sensitive") (:end . 244) (:start . 223) (:id . 79))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 250)\n  (:start . 245) (:id . 80))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 257)\n  (:start . 251) (:id . 81))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 262) (:start . 258)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 271)\n  (:start . 263) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1212.4.1) (:span 13 20)))\n (:hscopes ((:id . :x1212.4.1) (:span 13 158)))\n (:identifiers (:sid . :s1212.4) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011258@unknown@formal@none@1@S@Whereas IL-4 had little or no effect, IL-7 delayed both the apoptosis and cell cycle arrest that occur upon v-Abl kinase inactivation.@(((:tag . "IN") (:stem . "whereas") (:form . "Whereas") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "delay") (:form . "delayed") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 102)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 133)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1212.5.1) (:span 27 29)))\n (:nscopes ((:id . :x1212.5.1) (:span 27 36)))\n (:identifiers (:sid . :s1212.5) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011260@unknown@formal@none@1@S@IL-7 did not maintain v-Abl-mediated differentiation arrest of the pre-B cells, as activation of NF-kappaB and RAG gene transcription was unaffected by IL-7.@(((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "v-abl-mediated") (:form . "v-Abl-mediated")\n  (:end . 36) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 52) (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RAG") (:form . "RAG") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 133) (:start . 120) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 148)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1212.7.1) (:span 9 12)))\n (:nscopes ((:id . :x1212.7.1) (:span 9 78)))\n (:identifiers (:sid . :s1212.7) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011261@unknown@formal@none@1@S@These results identify a potential role for IL-7 signaling pathways in transformation by v-Abl while demonstrating that a combination of IL-4 and IL-7 signaling cannot substitute for an active v-Abl kinase in transformed pre-B cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 85) (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 114) (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 133)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-7") (:form . "IL-7") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "JJ") (:stem . "cannot") (:form . "cannot") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "VB") (:stem . "substitute") (:form . "substitute") (:end . 178)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 185) (:start . 183)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 192)\n  (:start . 186) (:id . 70))\n ((:tag . "NN") (:stem . "v-abl") (:form . "v-Abl") (:end . 198)\n  (:start . 193) (:id . 71))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 205)\n  (:start . 199) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 220)\n  (:start . 209) (:id . 74))\n ((:tag . "JJ") (:stem . "pre-b") (:form . "pre-B") (:end . 226)\n  (:start . 221) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 232)\n  (:start . 227) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1212.8.2) (:span 25 34)))\n (:ncues ((:id . :x1212.8.1) (:span 161 167)))\n (:hscopes ((:id . :x1212.8.2) (:span 25 94)))\n (:nscopes ((:id . :x1212.8.1) (:span 161 232)))\n (:identifiers (:sid . :s1212.8) (:did . :|9794389|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011262@unknown@formal@none@1@S@p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes.@(((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "initiate") (:form . "initiates") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phosphatidyl") (:form . "phosphatidyl") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "inositol") (:form . "inositol") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kinase/pkb") (:form . "kinase/PKB") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1213.1.1) (:span 27 30)))\n (:nscopes ((:id . :x1213.1.1) (:span 27 65)))\n (:identifiers (:sid . :s1213.1) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011263@unknown@formal@none@1@S@p21ras is activated by the T cell antigen receptor (TCR) and then co-ordinates important signaling pathways for T lymphocyte activation.@(((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 65) (:start . 61)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "coordinate") (:form . "co-ordinates") (:end . 78)\n  (:start . 66) (:id . 56))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 98)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 124)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1213.2) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011264@unknown@formal@none@1@S@Effector pathways for this guanine nucleotide binding protein in T cells are mediated by the serine/threonine kinase Raf-1 and the Ras-related GTPase Rac-1.@(((:tag . "NN") (:stem . "effector") (:form . "Effector") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "guanine") (:form . "guanine") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 53)\n  (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 109) (:start . 93) (:id . 57))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "NNP") (:stem . "Raf-1") (:form . "Raf-1") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "ras-related") (:form . "Ras-related") (:end . 142)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "gtpase") (:form . "GTPase") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1213.3) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011265@unknown@formal@none@1@S@In fibroblasts, an important effector for the Ras oncogene is Phosphatidylinositol 3-kinase (PtdIns 3-kinase).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "oncogene") (:form . "oncogene") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Phosphatidylinositol")\n  (:form . "Phosphatidylinositol") (:end . 82) (:start . 62) (:id . 53))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1213.4) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011266@unknown@formal@none@1@S@Activation of this lipid kinase is able to induce critical Rac-1 signaling pathways and can couple p21ras to cell survival mechanisms via the serine/threonine kinase Akt/PKB.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lipid") (:form . "lipid") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "couple") (:form . "couple") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "serine/threonine") (:form . "serine/threonine")\n  (:end . 158) (:start . 142) (:id . 65))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "NNP") (:stem . "Akt/PKB") (:form . "Akt/PKB") (:end . 173)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1213.5) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011267@unknown@formal@none@1@S@The role of PtdIns 3-kinase in Ras signaling in T cells has not been explored.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1213.6.1) (:span 60 63)))\n (:nscopes ((:id . :x1213.6.1) (:span 0 77)))\n (:identifiers (:sid . :s1213.6) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011268@unknown@formal@none@1@S@In the present study, we examined the ability of PtdIns 3-kinase to initiate the Rac-1 signaling pathways important for T cell activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1213.7) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011270@unknown@formal@none@1@S@The results show that Ras can initiate a Rac-1 mediated pathway that regulates the transcriptional function of AP-1 complexes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ras") (:form . "Ras") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 98) (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1213.9) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011271@unknown@formal@none@1@S@PtdIns 3-kinase signals cannot mimic p21ras and induce the Rac mediated responses of AP-1 transcriptional activation.@(((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "RB") (:stem . "cannot") (:form . "cannot") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "VB") (:stem . "mimic") (:form . "mimic") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rac") (:form . "Rac") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 105) (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1213.10.1) (:span 24 30)))\n (:nscopes ((:id . :x1213.10.1) (:span 24 116)))\n (:identifiers (:sid . :s1213.10) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011272@unknown@formal@none@1@S@Moreover, neither TCR or Ras activation of AP-1 is dependent on PtdIns 3-kinase.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1213.11.1) (:span 10 17)))\n (:nscopes ((:id . :x1213.11.1) (:span 10 79)))\n (:identifiers (:sid . :s1213.11) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011273@unknown@formal@none@1@S@PKB is activated in response to triggering of the T cell antigen receptor; PtdIns 3-kinase activity is both required and sufficient for this TCR response.@(((:tag . "NNP") (:stem . "PKB") (:form . "PKB") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "triggering") (:form . "triggering") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 153)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1213.12) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011274@unknown@formal@none@1@S@In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p21ras") (:form . "p21ras") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unable") (:form . "unable") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "Akt/PKB") (:form . "Akt/PKB") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ras") (:form . "Ras") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Akt/PKB") (:form . "Akt/PKB") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 139)\n  (:start . 131) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1213.13.1) (:span 76 79))\n  ((:id . :x1213.13.2) (:span 32 38)))\n (:nscopes ((:id . :x1213.13.1) (:span 76 150))\n  ((:id . :x1213.13.2) (:span 13 75)))\n (:identifiers (:sid . :s1213.13) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011275@unknown@formal@none@1@S@The present data thus highlight that PtdIns 3-kinase and Akt/PKB are not universal Ras effector molecules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "highlight") (:form . "highlight") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Akt/PKB") (:form . "Akt/PKB") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "universal") (:form . "universal") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1213.14.1) (:span 69 72)))\n (:nscopes ((:id . :x1213.14.1) (:span 69 105)))\n (:identifiers (:sid . :s1213.14) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011276@unknown@formal@none@1@S@Ras can initiate Rac-1 regulated signaling pathways in the context of T cell antigen receptor function independently of PtdIns 3-kinase activity.@(((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "rac-1") (:form . "Rac-1") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "regulated") (:form . "regulated") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PtdIns") (:form . "PtdIns") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1213.15) (:did . :|9796702|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011277@unknown@formal@none@1@S@Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy.@(((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 33)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "advance") (:form . "advanced") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 95) (:start . 94)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 126)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 138)\n  (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 146)\n  (:start . 139) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1214.1) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011278@unknown@formal@none@1@S@Studies have demonstrated abnormalities of the CD3/T-cell antigen receptor (TCR) and pathways of signal transduction in T lymphocytes from animals and patients with advanced malignancy.@(((:tag . "NNPS") (:stem . "Study") (:form . "Studies") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 39)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd3/t-cell") (:form . "CD3/T-cell") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 116)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 133)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "advanced") (:form . "advanced") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "malignancy") (:form . "malignancy") (:end . 184)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1214.2) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011280@unknown@formal@none@1@S@These defects have been described in T cells from patients with malignant melanoma, renal cell carcinoma (RCC), ovarian cancer, and colorectal cancer.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "malignant") (:form . "malignant") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "melanoma") (:form . "melanoma") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "ovarian") (:form . "ovarian") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "colorectal") (:form . "colorectal") (:end . 142)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 149)\n  (:start . 143) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1214.4) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011281@unknown@formal@none@1@S@Preliminary observations also indicate possible correlation with clinical variables such as stage in selected instances.@(((:tag . "JJ") (:stem . "preliminary") (:form . "Preliminary") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 29) (:start . 25)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 47)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 59)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "NNS") (:stem . "variable") (:form . "variables") (:end . 83)\n  (:start . 74) (:id . 50))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 88) (:start . 84)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 119)\n  (:start . 110) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1214.5.1) (:span 39 47)))\n (:hscopes ((:id . :x1214.5.1) (:span 39 119)))\n (:identifiers (:sid . :s1214.5) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011282@unknown@formal@none@1@S@To further characterize altered expression of TCRzeta, p56(lck), and impaired activation of NFkappaB, T lymphocytes were obtained from 65 patients with RCC, the majority of whom were receiving combination cytokine therapy [interleukin (IL)-2, IFN alpha-containing regimens] and 37 control individuals.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . 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5011283@unknown@formal@none@1@S@In 29 of these patients, levels of TCRzeta and p56(lck) were determined by Western blots of T-cell lysates and semiquantitated using densitometry.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 55)\n  (:start . 47) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "semiquantitate") (:form . "semiquantitated")\n  (:end . 126) (:start . 111) (:id . 62))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 132) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "densitometry") (:form . "densitometry") (:end . 145)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1214.7) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011284@unknown@formal@none@1@S@Relative levels were then correlated with a series of clinical variables including response to therapy, performance status, survival, disease sites, age, and others.@(((:tag . "JJ") (:stem . "relative") (:form . "Relative") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "variable") (:form . "variables") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 115)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "status") (:form . "status") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1214.8) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011285@unknown@formal@none@1@S@In another group of 28 patients (three individuals from the first group), the frequency of abnormal NFkappaB activation was studied using electrophoretic mobility shift assays after activation of T cells with phorbol myristate acetate/ionomycin or anti-CD3 monoclonal antibody.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 50)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 87)\n  (:start . 78) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 108)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 137) (:start . 132)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 153) (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 162)\n  (:start . 154) (:id . 67))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 168)\n  (:start . 163) (:id . 68))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 192)\n  (:start . 182) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 216)\n  (:start . 209) (:id . 76))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 226)\n  (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "acetate/ionomycin") (:form . "acetate/ionomycin")\n  (:end . 244) (:start . 227) (:id . 78))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 247) (:start . 245)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 256)\n  (:start . 248) (:id . 80))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 267)\n  (:start . 257) (:id . 81))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 276)\n  (:start . 268) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1214.9) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011286@unknown@formal@none@1@S@Changes in these signaling molecules during cytokine treatment were also investigated.@(((:tag . "NNS") (:stem . "change") (:form . "Changes") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 85)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1214.10) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011287@unknown@formal@none@1@S@TCRzeta and p56(lck) were detected in the peripheral blood T cells in 27 of 29 patients, and overall, reduced levels were noted visually in 12 of 29 (41%) and 13 of 29 (45%) individuals, respectively.@(((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "RB") (:stem . "overall") (:form . "overall") (:end . 100)\n  (:start . 93) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 109)\n  (:start . 102) (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 127)\n  (:start . 122) (:id . 65))\n ((:tag . "RB") (:stem . "visually") (:form . "visually") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 69))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 148) (:start . 146)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . "CD") (:stem . "41") (:form . "41") (:end . 152) (:start . 150)\n  (:id . 72))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 153) (:start . 152)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 75))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 161) (:start . 159)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 77))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 167) (:start . 165)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 79))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 171) (:start . 169)\n  (:id . 80))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 172) (:start . 171)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 185)\n  (:start . 174) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 84))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 199)\n  (:start . 187) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s1214.11) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011288@unknown@formal@none@1@S@When levels were semiquantitated using densitometry, significant decreases of TCRzeta (P = 0.029) and p56(lck) (P = 0.029) but not CD3epsilon (P = 0.131), compared with control levels, were found.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "semiquantitate") (:form . "semiquantitated")\n  (:end . 32) (:start . 17) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "densitometry") (:form . "densitometry") (:end . 51)\n  (:start . 39) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "0.029") (:form . "0.029") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.029") (:form . "0.029") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "CD3epsilon") (:form . "CD3epsilon") (:end . 141)\n  (:start . 131) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 144) (:start . 143)\n  (:id . 69))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 146) (:start . 145)\n  (:id . 70))\n ((:tag . "CD") (:stem . "0.131") (:form . "0.131") (:end . 152)\n  (:start . 147) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 163)\n  (:start . 155) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 75))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 176)\n  (:start . 169) (:id . 76))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 183)\n  (:start . 177) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 189) (:start . 185)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 195)\n  (:start . 190) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x1214.12.1) (:span 127 130)))\n (:nscopes ((:id . :x1214.12.1) (:span 127 153)))\n (:identifiers (:sid . :s1214.12) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011290@unknown@formal@none@1@S@Correlations of TCRzeta or p56(lck) levels with response or disease variables, except for lower TCRzeta levels (P < 0.001) in the presence of bone metastases, were not found.@(((:tag . "NNS") (:stem . "correlation") (:form . "Correlations") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "variable") (:form . "variables") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "bone") (:form . "bone") (:end . 146) (:start . 142)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "metastasis") (:form . "metastases") (:end . 157)\n  (:start . 147) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 167) (:start . 164)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 173)\n  (:start . 168) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1214.14.1) (:span 164 167)))\n (:nscopes ((:id . :x1214.14.1) (:span 0 173)))\n (:identifiers (:sid . :s1214.14) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011291@unknown@formal@none@1@S@Abnormal NFkappaB activation after stimulation with phorbol myristate acetate/ionomycin and/or anti-CD3 monoclonal antibody was found in 59% of patients (17 of 28) and was not accounted for by the advanced age of the study cohort.@(((:tag . "JJ") (:stem . "abnormal") (:form . "Abnormal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 46)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 69)\n  (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "acetate/ionomycin") (:form . "acetate/ionomycin")\n  (:end . 87) (:start . 70) (:id . 50))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 94)\n  (:start . 88) (:id . 51))\n ((:tag . "JJ") (:stem . "anti-cd3") (:form . "anti-CD3") (:end . 103)\n  (:start . 95) (:id . 52))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 114)\n  (:start . 104) (:id . 53))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 123)\n  (:start . 115) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 133)\n  (:start . 128) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 57))\n ((:tag . "CD") (:stem . "59") (:form . "59") (:end . 139) (:start . 137)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 140) (:start . 139)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 152)\n  (:start . 144) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 62))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "account") (:form . "accounted") (:end . 185)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "advanced") (:form . "advanced") (:end . 205)\n  (:start . 197) (:id . 74))\n ((:tag . "NN") (:stem . "age") (:form . "age") (:end . 209) (:start . 206)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 77))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 222)\n  (:start . 217) (:id . 78))\n ((:tag . "NN") (:stem . "cohort") (:form . "cohort") (:end . 229)\n  (:start . 223) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x1214.15.1) (:span 172 175)))\n (:nscopes ((:id . :x1214.15.1) (:span 168 229)))\n (:identifiers (:sid . :s1214.15) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011292@unknown@formal@none@1@S@Activation of NFkappaB in peripheral blood T cells was inducible during cytokine therapy in four of six individuals who displayed impaired NFkappaB activity prior to therapy.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "RB") (:stem . "prior") (:form . "prior") (:end . 162)\n  (:start . 157) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 173)\n  (:start . 166) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1214.16) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011293@unknown@formal@none@1@S@Moreover, impaired activation of NFkappaB does not appear linked to a reduction of TCRzeta expression, because in five patients, normal TCRzeta levels were present although kappaB binding was not inducible.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 64) (:start . 58)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 150)\n  (:start . 144) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 155) (:start . 151)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 179)\n  (:start . 173) (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 205)\n  (:start . 196) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1214.17.3) (:span 51 57)))\n (:ncues ((:id . :x1214.17.1) (:span 192 195))\n  ((:id . :x1214.17.2) (:span 47 50)))\n (:hscopes ((:id . :x1214.17.3) (:span 10 101)))\n (:nscopes ((:id . :x1214.17.1) (:span 173 205))\n  ((:id . :x1214.17.2) (:span 10 101)))\n (:identifiers (:sid . :s1214.17) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011294@unknown@formal@none@1@S@In the majority of patients with advanced RCC, peripheral blood T cells express TCRzeta and p56(lck), and in a subset, reduced levels of these TCRzeta associated molecules are seen that may increase during cytokine-based therapy.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "advance") (:form . "advanced") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "RCC") (:form . "RCC") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "p56(lck)") (:form . "p56(lck)") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 117)\n  (:start . 111) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 126)\n  (:start . 119) (:id . 65))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 142)\n  (:start . 137) (:id . 68))\n ((:tag . "NNP") (:stem . "TCRzeta") (:form . "TCRzeta") (:end . 150)\n  (:start . 143) (:id . 69))\n ((:tag . "JJ") (:stem . "associated") (:form . "associated") (:end . 161)\n  (:start . 151) (:id . 70))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 171)\n  (:start . 162) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 180) (:start . 176)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 189) (:start . 186)\n  (:id . 75))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 198)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 205)\n  (:start . 199) (:id . 77))\n ((:tag . "JJ") (:stem . "cytokine-based") (:form . "cytokine-based")\n  (:end . 220) (:start . 206) (:id . 78))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 228)\n  (:start . 221) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1214.18.1) (:span 186 189)))\n (:hscopes ((:id . :x1214.18.1) (:span 186 228)))\n (:identifiers (:sid . :s1214.18) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011295@unknown@formal@none@1@S@Abnormal activation of NFkappaB is also present in >50% of patients and may also revert to normal during IL-2/IFN alpha-based treatment.@(((:tag . "JJ") (:stem . "abnormal") (:form . "Abnormal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . ">50") (:form . ">50") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "VB") (:stem . "revert") (:form . "revert") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 97)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "il-2/ifn") (:form . "IL-2/IFN") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "JJ") (:stem . "alpha-based") (:form . "alpha-based") (:end . 125)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1214.19.1) (:span 72 75)))\n (:hscopes ((:id . :x1214.19.1) (:span 72 135)))\n (:identifiers (:sid . :s1214.19) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011296@unknown@formal@none@1@S@This alteration in NFkappaB activation occurred in the presence of normal expression of TCRzeta-associated signaling elements.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alteration") (:form . "alteration") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "tcrzeta-associated") (:form . "TCRzeta-associated")\n  (:end . 106) (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 116)\n  (:start . 107) (:id . 56))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1214.20) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011297@unknown@formal@none@1@S@The clinical significance of these findings remains unclear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "clinical") (:form . "clinical") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 50)))@@@1@9@((:hcues ((:id . :x1214.21.1) (:span 52 59)))\n (:hscopes ((:id . :x1214.21.1) (:span 0 59)))\n (:identifiers (:sid . :s1214.21) (:did . :|9796963|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011298@unknown@formal@none@1@S@Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 39)\n  (:start . 30) (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lipase") (:form . "lipase") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 70) (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 80)\n  (:start . 71) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 109) (:start . 96) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 117)\n  (:start . 110) (:id . 55))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 121) (:start . 118)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1215.1) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011300@unknown@formal@none@1@S@It is shown here that during monocyte to macrophage differentiation, the expression of LAL-mRNA is induced.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 67) (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LAL-mRNA") (:form . "LAL-mRNA") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1215.3) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011301@unknown@formal@none@1@S@This induction is dependent on protein kinase C activity and protein synthesis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1215.4) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011302@unknown@formal@none@1@S@The cell type-specific increase in LAL expression is further investigated in the THP-1 cell line with respect to transcriptional regulation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "type-specific") (:form . "type-specific")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lal") (:form . "LAL") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 128) (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1215.5) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011303@unknown@formal@none@1@S@The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with phorbol esters.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "differentiate") (:form . "differentiates")\n  (:end . 59) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 80) (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 99)\n  (:start . 92) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 104) (:start . 100)\n  (:id . 55))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "NNS") (:stem . "ester") (:form . "esters") (:end . 119)\n  (:start . 113) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1215.6) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011304@unknown@formal@none@1@S@In order to determine the cis-acting elements necessary for both basal and phorbol 12-myristate-13 acetate (PMA)-enhanced promoter activity, we performed deletion analysis and reporter gene assays.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "12-myristate-13") (:form . "12-myristate-13")\n  (:end . 98) (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "PMA)-enhanced") (:form . "PMA)-enhanced")\n  (:end . 121) (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 130)\n  (:start . 122) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 139)\n  (:start . 131) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 171)\n  (:start . 163) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 184)\n  (:start . 176) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 189) (:start . 185)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 196)\n  (:start . 190) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1215.7) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011305@unknown@formal@none@1@S@A PMA responsive element has been identified between -182 bp and -107 bp upstream of the major transcription start site.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "CD") (:stem . "-182") (:form . "-182") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "CD") (:stem . "-107") (:form . "-107") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1215.8) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011306@unknown@formal@none@1@S@Gel mobility shift assays demonstrated that binding of Sp1 and AP-2 to the LAL promoter is increased by PMA in THP-1 cells.@(((:tag . "NNP") (:stem . "Gel") (:form . "Gel") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lal") (:form . "LAL") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 116)\n  (:start . 111) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1215.9) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011307@unknown@formal@none@1@S@Co-transfections with expression plasmids for Sp1 and AP-2 further emphasized the important role of these transcription factors in both basal and PMA-enhanced LAL expression.@(((:tag . "NNS") (:stem . "co-transfection") (:form . "Co-transfections")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 44))\n ((:tag . "NNS") (:stem . "plasmid") (:form . "plasmids") (:end . 41)\n  (:start . 33) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "AP-2") (:form . "AP-2") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "VBD") (:stem . "emphasize") (:form . "emphasized") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 119) (:start . 106) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 127)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 135) (:start . 131)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pma-enhanced") (:form . "PMA-enhanced") (:end . 158)\n  (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "lal") (:form . "LAL") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1215.10) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011308@unknown@formal@none@1@S@Our data suggest that differentiation dependent increase of lysosomal acid lipase (LAL) expression in THP-1 cells is mediated by a concerted action of Sp1 and AP-2.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lysosomal") (:form . "lysosomal") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lipase") (:form . "lipase") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LAL") (:form . "LAL") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "concerted") (:form . "concerted") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "ap-2") (:form . "AP-2") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1215.11.1) (:span 9 16)))\n (:hscopes ((:id . :x1215.11.1) (:span 9 163)))\n (:identifiers (:sid . :s1215.11) (:did . :|9799798|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011310@unknown@formal@none@1@S@The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "pregnancy") (:form . "pregnancy") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "remain") (:form . "remained") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "JJ") (:stem . "elusive") (:form . "elusive") (:end . 125)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1216.2.1) (:span 118 125)))\n (:hscopes ((:id . :x1216.2.1) (:span 0 125)))\n (:identifiers (:sid . :s1216.2) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011311@unknown@formal@none@1@S@Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and reversibly blocks voltage-gated and calcium-activated K+ channels (KV and KCa, respectively), resulting in depolarization of the membrane potential.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 69)\n  (:start . 57) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 88) (:start . 74) (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "placenta") (:form . "placenta") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "RB") (:stem . "reversibly") (:form . "reversibly") (:end . 134)\n  (:start . 124) (:id . 65))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "JJ") (:stem . "voltage-gated") (:form . "voltage-gated")\n  (:end . 155) (:start . 142) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "calcium-activated") (:form . "calcium-activated")\n  (:end . 177) (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 191) (:start . 190)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "KV") (:form . "KV") (:end . 193) (:start . 191)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "KCa") (:form . "KCa") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 76))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 215)\n  (:start . 203) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 217) (:start . 216)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 227)\n  (:start . 218) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 81))\n ((:tag . "NN") (:stem . "depolarization") (:form . "depolarization")\n  (:end . 245) (:start . 231) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 252) (:start . 249)\n  (:id . 84))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 261)\n  (:start . 253) (:id . 85))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 271)\n  (:start . 262) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s1216.3) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011312@unknown@formal@none@1@S@As a result, Ca2+ signaling and nuclear factor of activated T cells (NF-AT)-driven gene expression are inhibited.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-AT)-driven") (:form . "NF-AT)-driven")\n  (:end . 82) (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 112)\n  (:start . 103) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1216.4) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011313@unknown@formal@none@1@S@Progesterone acts distally to the initial steps of T cell receptor (TCR)-mediated signal transduction, since it blocks sustained Ca2+ signals after thapsigargin stimulation, as well as oscillatory Ca2+ signals, but not the Ca2+ transient after TCR stimulation.@(((:tag . "NNP") (:stem . "Progesterone") (:form . "Progesterone") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "RB") (:stem . "distally") (:form . "distally") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "TCR)-mediated") (:form . "TCR)-mediated")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 101)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "sustained") (:form . "sustained") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "thapsigargin") (:form . "thapsigargin") (:end . 160)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 172)\n  (:start . 161) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 176) (:start . 174)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "oscillatory") (:form . "oscillatory") (:end . 196)\n  (:start . 185) (:id . 71))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 201) (:start . 197)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 209)\n  (:start . 202) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 74))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 214) (:start . 211)\n  (:id . 75))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 218) (:start . 215)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 227) (:start . 223)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 237)\n  (:start . 228) (:id . 79))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 243)\n  (:start . 238) (:id . 80))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 247) (:start . 244)\n  (:id . 81))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 259)\n  (:start . 248) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x1216.5.1) (:span 215 218)))\n (:nscopes ((:id . :x1216.5.1) (:span 215 259)))\n (:identifiers (:sid . :s1216.5) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011314@unknown@formal@none@1@S@K+ channel blockade by progesterone is specific; other steroid hormones had little or no effect, although the progesterone antagonist RU 486 also blocked KV and KCa channels.@(((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "channel") (:form . "channel") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "blockade") (:form . "blockade") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 122)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "antagonist") (:form . "antagonist") (:end . 133)\n  (:start . 123) (:id . 62))\n ((:tag . "NNP") (:stem . "RU") (:form . "RU") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "CD") (:stem . "486") (:form . "486") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 153)\n  (:start . 146) (:id . 66))\n ((:tag . "NNP") (:stem . "KV") (:form . "KV") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "KCa") (:form . "KCa") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x1216.6.1) (:span 86 88)))\n (:nscopes ((:id . :x1216.6.1) (:span 86 95)))\n (:identifiers (:sid . :s1216.6) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011315@unknown@formal@none@1@S@Progesterone effectively blocked a broad spectrum of K+ channels, reducing both Kv1.3 and charybdotoxin-resistant components of KV current and KCa current in T cells, as well as blocking several cloned KV channels expressed in cell lines.@(((:tag . "NNP") (:stem . "Progesterone") (:form . "Progesterone") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 32)\n  (:start . 25) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "broad") (:form . "broad") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "spectrum") (:form . "spectrum") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "kv1.3") (:form . "Kv1.3") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "charybdotoxin-resistant")\n  (:form . "charybdotoxin-resistant") (:end . 113) (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 124)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "KV") (:form . "KV") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "NN") (:stem . "current") (:form . "current") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "KCa") (:form . "KCa") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "current") (:form . "current") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 174) (:start . 170)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 186)\n  (:start . 178) (:id . 71))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 194)\n  (:start . 187) (:id . 72))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "NNP") (:stem . "KV") (:form . "KV") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 213)\n  (:start . 205) (:id . 75))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 223)\n  (:start . 214) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 231) (:start . 227)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 237)\n  (:start . 232) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1216.7) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011316@unknown@formal@none@1@S@Progesterone had little or no effect on a cloned voltage-gated Na+ channel, an inward rectifier K+ channel, or on lymphocyte Ca2+ and Cl- channels.@(((:tag . "NNP") (:stem . "Progesterone") (:form . "Progesterone") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "voltage-gated") (:form . "voltage-gated")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "na+") (:form . "Na+") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "channel") (:form . "channel") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "inward") (:form . "inward") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "rectifier") (:form . "rectifier") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "channel") (:form . "channel") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "ca2+") (:form . "Ca2+") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cl-") (:form . "Cl-") (:end . 137) (:start . 134)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1216.8.1) (:span 27 29)))\n (:nscopes ((:id . :x1216.8.1) (:span 27 146)))\n (:identifiers (:sid . :s1216.8) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011317@unknown@formal@none@1@S@We propose that direct inhibition of K+ channels in T cells by progesterone contributes to progesterone-induced immunosuppression.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "k+") (:form . "K+") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "channel") (:form . "channels") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "progesterone") (:form . "progesterone") (:end . 75)\n  (:start . 63) (:id . 54))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "progesterone-induced")\n  (:form . "progesterone-induced") (:end . 111) (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "immunosuppression") (:form . "immunosuppression")\n  (:end . 129) (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1216.9.1) (:span 3 10)))\n (:hscopes ((:id . :x1216.9.1) (:span 3 129)))\n (:identifiers (:sid . :s1216.9) (:did . :|9802971|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011318@unknown@formal@none@1@S@Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ikk1") (:form . "IKK1") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ikk2") (:form . "IKK2") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 43) (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1217.1) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011320@unknown@formal@none@1@S@Bacterial lipopolysaccharide (LPS) induces monocytes to express a variety of genes by activating the NF-kappaB/Rel transcription factor family.@(((:tag . "JJ") (:stem . "bacterial") (:form . "Bacterial") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 28) (:start . 10) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 114) (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 128) (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 135)\n  (:start . 129) (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 142)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1217.3) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011321@unknown@formal@none@1@S@Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "IKK1") (:form . "IKK1") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IKK2") (:form . "IKK2") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1217.4) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011322@unknown@formal@none@1@S@Phosphorylation of the IkappaB cytoplasmic inhibitors, IkappaBalpha, IkappaBbeta, and IkappaBepsilon, by these kinases triggers proteolytic degradation and the release of NF-kappaB/Rel proteins into the nucleus.@(((:tag . "NN") (:stem . "phosphorylation") (:form . "Phosphorylation")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 42)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 53)\n  (:start . 43) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 67)\n  (:start . 55) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaBbeta") (:form . "IkappaBbeta") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IkappaBepsilon") (:form . "IkappaBepsilon")\n  (:end . 100) (:start . 86) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "kinase") (:form . "kinases") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 139)\n  (:start . 128) (:id . 60))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 151)\n  (:start . 140) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 167)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB/Rel") (:form . "NF-kappaB/Rel")\n  (:end . 184) (:start . 171) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 193)\n  (:start . 185) (:id . 67))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 198) (:start . 194)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 69))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 210)\n  (:start . 203) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1217.5) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011323@unknown@formal@none@1@S@At present, the role of the IKKs in LPS signaling has not been investigated.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "ikk") (:form . "IKKs") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 49)\n  (:start . 40) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 75)\n  (:start . 63) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1217.6.1) (:span 54 57)))\n (:nscopes ((:id . :x1217.6.1) (:span 12 75)))\n (:identifiers (:sid . :s1217.6) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011324@unknown@formal@none@1@S@Here, we report that LPS induces IKK activity in human monocytes and THP-1 monocytic cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 15)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "NNP") (:stem . "IKK") (:form . "IKK") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1217.7) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011325@unknown@formal@none@1@S@The kinetics of activation of kinase activity in monocytic cells are relatively slow with maximal activity observed at 60 min, which coincides with the degradation of IkappaBs and the nuclear translocation of NF-kappaB.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "kinetic") (:form . "kinetics") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "maximal") (:form . "maximal") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "VBZ") (:stem . "coincide") (:form . "coincides") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 163)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaBs") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 205) (:start . 192) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 218)\n  (:start . 209) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1217.8) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011326@unknown@formal@none@1@S@In transfection experiments, overexpression of wild type IKK1, a dominant negative mutant IKK1 (K44M), or wild type IKK2 did not affect LPS-induced kappaB-dependent transcription in monocytic cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 43) (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ikk1") (:form . "IKK1") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "ikk1") (:form . "IKK1") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "K44M") (:form . "K44M") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ikk2") (:form . "IKK2") (:end . 120) (:start . 116)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 128) (:start . 125)\n  (:id . 66))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 135)\n  (:start . 129) (:id . 67))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 147)\n  (:start . 136) (:id . 68))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 164) (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 178) (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 191)\n  (:start . 182) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1217.9.1) (:span 125 128)))\n (:nscopes ((:id . :x1217.9.1) (:span 125 197)))\n (:identifiers (:sid . :s1217.9) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011327@unknown@formal@none@1@S@In contrast, a dominant negative mutant of IKK2 inhibited LPS induction of kappaB-dependent transcription in a dose-dependent manner.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IKK2") (:form . "IKK2") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 91) (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 105) (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dose-dependent") (:form . "dose-dependent")\n  (:end . 125) (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 132)\n  (:start . 126) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1217.10) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011328@unknown@formal@none@1@S@These results indicate that LPS induction of kappaB-dependent gene expression in human monocytic cells requires activation of IKK2.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "kappab-dependent") (:form . "kappaB-dependent")\n  (:end . 61) (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 96)\n  (:start . 87) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 111)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ikk2") (:form . "IKK2") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1217.11.1) (:span 14 27)))\n (:hscopes ((:id . :x1217.11.1) (:span 14 130)))\n (:identifiers (:sid . :s1217.11) (:did . :|9804806|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011330@unknown@formal@none@1@S@The association and activation of the IL-1 receptor-associated protein kinase (IRAK) to the IL-1 receptor complex is one of the earliest events detectable in IL-1 signal transduction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 62) (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 143)\n  (:start . 137) (:id . 65))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 154)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 169)\n  (:start . 163) (:id . 69))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 182)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1218.2) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011331@unknown@formal@none@1@S@We generated permanent clones of the murine T cell line EL4 6.1 overexpressing human (h)IRAK to evaluate the role of this kinase in IL-1 signaling.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "permanent") (:form . "permanent") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "el4") (:form . "EL4") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "6.1") (:form . "6.1") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 78) (:start . 64) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "h)IRAK") (:form . "h)IRAK") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "il-1") (:form . "IL-1") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 146)\n  (:start . 137) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1218.3) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011332@unknown@formal@none@1@S@Overexpression of hIRAK enhanced IL-1-stimulated activation of the transcription factor NFkappaB, whereas a truncated form (N-IRAK) specifically inhibited IL-1-dependent NFkappaB activity.@(((:tag . "NN") (:stem . "overexpression") (:form . "Overexpression")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hirak") (:form . "hIRAK") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "il-1-stimulated") (:form . "IL-1-stimulated")\n  (:end . 48) (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 59)\n  (:start . 49) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 80) (:start . 67) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 87)\n  (:start . 81) (:id . 51))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 96)\n  (:start . 88) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 105)\n  (:start . 98) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 122) (:start . 118)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "N-IRAK") (:form . "N-IRAK") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 144)\n  (:start . 132) (:id . 61))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 154)\n  (:start . 145) (:id . 62))\n ((:tag . "JJ") (:stem . "il-1-dependent") (:form . "IL-1-dependent")\n  (:end . 169) (:start . 155) (:id . 63))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 178)\n  (:start . 170) (:id . 64))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 187)\n  (:start . 179) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1218.4) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011333@unknown@formal@none@1@S@In clones stably overexpressing hIRAK a weak constitutive activation of NFkappaB correlated with a low basal IL-2 production which was enhanced in an IL-1-dependent manner.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBG") (:stem . "overexpresse") (:form . "overexpressing")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "hirak") (:form . "hIRAK") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 91)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "il-1-dependent") (:form . "IL-1-dependent")\n  (:end . 164) (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 171)\n  (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1218.5) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011334@unknown@formal@none@1@S@Compared to the parental cell line the dose-response curve of IL-1-induced IL-2 production was shifted in both potency and efficacy.@(((:tag . "VBN") (:stem . "compare") (:form . "Compared") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "parental") (:form . "parental") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dose-response") (:form . "dose-response")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "curve") (:form . "curve") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "il-1-induced") (:form . "IL-1-induced") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "shift") (:form . "shifted") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "potency") (:form . "potency") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "efficacy") (:form . "efficacy") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1218.6) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011335@unknown@formal@none@1@S@These results demonstrate that IRAK directly triggers NFkappaB-mediated gene expression in EL4 cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "IRAK") (:form . "IRAK") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "trigger") (:form . "triggers") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "JJ") (:stem . "nfkappab-mediated") (:form . "NFkappaB-mediated")\n  (:end . 71) (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "NN") (:stem . "el4") (:form . "EL4") (:end . 94) (:start . 91)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1218.7) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011336@unknown@formal@none@1@S@Qualitatively different effects were observed for the IL-1-induced activation of stress-activated protein (SAP) kinases: permanent overexpression of IRAK did not affect the dose dependence but prolonged the kinetics of IL-1-induced activation of SAP kinases, suggesting that this signaling branch may be regulated by distinct mechanisms.@(((:tag . "RB") (:stem . "qualitatively") (:form . "Qualitatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . 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"by") (:end . 316) (:start . 314)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 325)\n  (:start . 317) (:id . 89))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 336)\n  (:start . 326) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 337) (:start . 336)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x1218.8.1) (:span 297 300))\n  ((:id . :x1218.8.2) (:span 259 269)))\n (:ncues ((:id . :x1218.8.3) (:span 158 161)))\n (:hscopes ((:id . :x1218.8.1) (:span 297 336))\n  ((:id . :x1218.8.2) (:span 259 336)))\n (:nscopes ((:id . :x1218.8.3) (:span 158 188)))\n (:identifiers (:sid . :s1218.8) (:did . :|9808178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011337@unknown@formal@none@1@S@Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB.@(((:tag . "VBN") (:stem . "decrease") (:form . "Decreased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "JJ") (:stem . "salicylic") (:form . "salicylic") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "JJ") (:stem . "acid-mediated") (:form . "acid-mediated")\n  (:end . 85) (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 96)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 109)\n  (:start . 100) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1219.1) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011338@unknown@formal@none@1@S@IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains.@(((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "75-kda") (:form . "75-kDa") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "JJ") (:stem . "heterodimeric") (:form . "heterodimeric")\n  (:end . 31) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "RB") (:stem . "covalently") (:form . "covalently") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 74) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "p35") (:form . "p35") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1219.2) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011340@unknown@formal@none@1@S@Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflammatory autoimmune diseases.@(((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 75)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 99)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "autoimmune") (:form . "autoimmune") (:end . 110)\n  (:start . 100) (:id . 55))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1219.4) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011341@unknown@formal@none@1@S@Thus, IL-12 appears to be a critical factor in the generation and maintenance of chronic inflammatory conditions.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "maintenance") (:form . "maintenance") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "chronic") (:form . "chronic") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 101)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1219.5.1) (:span 12 19)))\n (:hscopes ((:id . :x1219.5.1) (:span 6 112)))\n (:identifiers (:sid . :s1219.5) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011342@unknown@formal@none@1@S@In this study, we investigated the effects of a commonly prescribed anti-inflammatory drug, acetyl salicylic acid (ASA), on IL-12 production and Th1 cell development.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 30)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBN") (:stem . "prescribe") (:form . "prescribed") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 85) (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "acetyl") (:form . "acetyl") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "JJ") (:stem . "salicylic") (:form . "salicylic") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "ASA") (:form . "ASA") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 165)\n  (:start . 154) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1219.6) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011343@unknown@formal@none@1@S@ASA was found to inhibit secretion of the IL-12 heterodimer as well as p40 monomer by human monocytic cells.@(((:tag . "NNP") (:stem . "ASA") (:form . "ASA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "monomer") (:form . "monomer") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1219.7) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011344@unknown@formal@none@1@S@This was associated with the down-regulation of IL-12p40 mRNA expression.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 44) (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-12p40") (:form . "IL-12p40") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1219.8) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011345@unknown@formal@none@1@S@Analysis of the regulation of the p40 gene promoter revealed that ASA inhibited NF-kappaB activation and binding to the p40-kappaB site in the p40 promoter, leading to transcriptional repression of the p40 gene.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ASA") (:form . "ASA") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p40-kappab") (:form . "p40-kappaB") (:end . 130)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 146) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 183) (:start . 168) (:id . 70))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 210) (:start . 206)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1219.9) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011346@unknown@formal@none@1@S@Addition of ASA to an in vitro T helper cell differentiation system, at concentrations compatible with plasma levels reached during anti-inflammatory therapy, resulted in reduced development of Th1 cells.@(((:tag . "NN") (:stem . "addition") (:form . "Addition") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ASA") (:form . "ASA") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 60) (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 86) (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "compatible") (:form . "compatible") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "VBN") (:stem . "reach") (:form . "reached") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "JJ") (:stem . "anti-inflammatory") (:form . "anti-inflammatory")\n  (:end . 149) (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 190)\n  (:start . 179) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 197) (:start . 194)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 203)\n  (:start . 198) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1219.10) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011347@unknown@formal@none@1@S@These results suggest that the inhibition of NF-kappaB activation by ASA leads to down-regulation of IL-12 production and inhibition of Th1 cell development.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ASA") (:form . "ASA") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 97) (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "th1") (:form . "Th1") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 156)\n  (:start . 145) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1219.11.1) (:span 14 21)))\n (:hscopes ((:id . :x1219.11.1) (:span 14 156)))\n (:identifiers (:sid . :s1219.11) (:did . :|9808189|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011348@unknown@formal@none@1@S@YM268 increases the glucose uptake, cell differentiation, and mRNA expression of glucose transporter in 3T3-L1 adipocytes.@(((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 56) (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "transporter") (:form . "transporter") (:end . 100)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "3t3-l1") (:form . "3T3-L1") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NNS") (:stem . "adipocyte") (:form . "adipocytes") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1220.1) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011350@unknown@formal@none@1@S@YM268 and pioglitazone dose-dependently increased the 2-deoxyglucose uptake in 3T3-L1 cells.@(((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pioglitazone") (:form . "pioglitazone") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 39) (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 49)\n  (:start . 40) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "2-deoxyglucose") (:form . "2-deoxyglucose")\n  (:end . 68) (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 75)\n  (:start . 69) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "NN") (:stem . "3t3-l1") (:form . "3T3-L1") (:end . 85)\n  (:start . 79) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 91) (:start . 86)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1220.3) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011351@unknown@formal@none@1@S@YM268 facilitated the insulin-stimulated triglyceride accumulation in 3T3-L1 adipocytes and increased the mRNA expression of fatty acid-binding protein.@(((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "facilitate") (:form . "facilitated") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "insulin-stimulated") (:form . "insulin-stimulated")\n  (:end . 40) (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "triglyceride") (:form . "triglyceride") (:end . 53)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 66)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 48))\n ((:tag . "NN") (:stem . "3t3-l1") (:form . "3T3-L1") (:end . 76)\n  (:start . 70) (:id . 49))\n ((:tag . "NNS") (:stem . "adipocyte") (:form . "adipocytes") (:end . 87)\n  (:start . 77) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 101)\n  (:start . 92) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 110) (:start . 106)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 121)\n  (:start . 111) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 130)\n  (:start . 125) (:id . 57))\n ((:tag . "JJ") (:stem . "acid-binding") (:form . "acid-binding") (:end . 143)\n  (:start . 131) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 151)\n  (:start . 144) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1220.4) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011352@unknown@formal@none@1@S@YM268, with and without insulin, increased the mRNA expression of glucose transporter isoforms such as GLUT1 and GLUT4, indicating enhancement of adipocyte differentiation.@(((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "insulin") (:form . "insulin") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "transporter") (:form . "transporter") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "GLUT1") (:form . "GLUT1") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GLUT4") (:form . "GLUT4") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 130)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 142)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "NN") (:stem . "adipocyte") (:form . "adipocyte") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 171) (:start . 156) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1220.5.1) (:span 16 23)))\n (:nscopes ((:id . :x1220.5.1) (:span 16 31)))\n (:identifiers (:sid . :s1220.5) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011353@unknown@formal@none@1@S@Additionally, YM268 and pioglitazone showed activity of the PPARgamma ligand, a member of the nuclear receptor superfamily responsible for adipogenesis.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pioglitazone") (:form . "pioglitazone") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 43) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 134)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "adipogenesis") (:form . "adipogenesis") (:end . 151)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1220.6) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011354@unknown@formal@none@1@S@To examine the possible involvement of the increased activity of PI 3-kinase in YM268-stimulated glucose uptake, the enzyme activity was estimated by measuring the phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentration in human monocytic cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ym268-stimulated") (:form . "YM268-stimulated")\n  (:end . 96) (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 123)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "measure") (:form . "measuring") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "VB") (:stem . "phosphatidylinositol-3,4,5-trisphosphate")\n  (:form . "phosphatidylinositol-3,4,5-trisphosphate") (:end . 204)\n  (:start . 164) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "PI-3,4,5-P3") (:form . "PI-3,4,5-P3") (:end . 217)\n  (:start . 206) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 218) (:start . 217)\n  (:id . 70))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 232) (:start . 219) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 235) (:start . 233)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 241)\n  (:start . 236) (:id . 73))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 251)\n  (:start . 242) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 257)\n  (:start . 252) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 258) (:start . 257)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1220.7.1) (:span 15 23)))\n (:hscopes ((:id . :x1220.7.1) (:span 15 111)))\n (:identifiers (:sid . :s1220.7) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011355@unknown@formal@none@1@S@Insulin dose-dependently increased the PI-3,4,5-P3 production but YM268 had no significant effect on the insulin-dependent and -independent PI 3-kinase activation.@(((:tag . "NN") (:stem . "insulin") (:form . "Insulin") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 24) (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 34)\n  (:start . 25) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "PI-3,4,5-P3") (:form . "PI-3,4,5-P3") (:end . 50)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 61)\n  (:start . 51) (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 71) (:start . 66)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 75) (:start . 72)\n  (:id . 50))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 90)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 97)\n  (:start . 91) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "insulin-dependent") (:form . "insulin-dependent")\n  (:end . 122) (:start . 105) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 139)\n  (:start . 127) (:id . 58))\n ((:tag . "NNP") (:stem . "PI") (:form . "PI") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "3-kinase") (:form . "3-kinase") (:end . 151)\n  (:start . 143) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1220.8.1) (:span 76 78)))\n (:nscopes ((:id . :x1220.8.1) (:span 76 162)))\n (:identifiers (:sid . :s1220.8) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011356@unknown@formal@none@1@S@These results indicate that the mechanism by which YM268 increased glucose uptake, may be accounted for in part by the enhancement of GLUT1 and GLUT4 expression through PPARgamma activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ym268") (:form . "YM268") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "glucose") (:form . "glucose") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "account") (:form . "accounted") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 130)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "glut1") (:form . "GLUT1") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "glut4") (:form . "GLUT4") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 160)\n  (:start . 150) (:id . 68))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "NNP") (:stem . "PPARgamma") (:form . "PPARgamma") (:end . 178)\n  (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 189)\n  (:start . 179) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1220.9.1) (:span 83 86))\n  ((:id . :x1220.9.2) (:span 14 27)))\n (:hscopes ((:id . :x1220.9.1) (:span 83 189))\n  ((:id . :x1220.9.2) (:span 14 189)))\n (:identifiers (:sid . :s1220.9) (:did . :|9808320|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011357@unknown@formal@none@1@S@Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes.@(((:tag . "NN") (:stem . "interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "erythrocyte") (:form . "erythrocytes") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 51)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 88)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "conditioned") (:form . "conditioned") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 112)\n  (:start . 106) (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 143)\n  (:start . 136) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transendothelial") (:form . "transendothelial")\n  (:end . 163) (:start . 147) (:id . 62))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 173)\n  (:start . 164) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 186)\n  (:start . 177) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1221.1) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011358@unknown@formal@none@1@S@The abnormal adherence of sickle red blood cells (SS RBC) to endothelial cells has been thought to contribute to vascular occlusion, a major cause of morbidity in sickle cell disease (SCD).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "adherence") (:form . "adherence") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 72)\n  (:start . 61) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 109)\n  (:start . 99) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "occlusion") (:form . "occlusion") (:end . 131)\n  (:start . 122) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 146)\n  (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "NN") (:stem . "morbidity") (:form . "morbidity") (:end . 159)\n  (:start . 150) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 169)\n  (:start . 163) (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 182)\n  (:start . 175) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "SCD") (:form . "SCD") (:end . 187) (:start . 184)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1221.2.1) (:span 88 95)))\n (:hscopes ((:id . :x1221.2.1) (:span 0 188)))\n (:identifiers (:sid . :s1221.2) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011360@unknown@formal@none@1@S@We showed that the interaction of SS RBC at 2% concentration in the presence of multimers of von Willebrand factor (vWf), derived from endothelial cell-derived conditioned medium (E-CM) with cultured human umbilical vein endothelial cells (HUVEC), resulted in a fivefold increased formation of thiobarbituric acid-reactive substances (TBARS) and activation of the transcription factor NF-kB, both indicators of cellular oxidant stress.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . 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5011361@unknown@formal@none@1@S@Normal RBC show none of these phenomena.@(((:tag . "JJ") (:stem . "normal") (:form . "Normal") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "phenomenon") (:form . "phenomena") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 40) (:start . 39)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x1221.5.1) (:span 16 20)))\n (:nscopes ((:id . :x1221.5.1) (:span 16 39)))\n (:identifiers (:sid . :s1221.5) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011362@unknown@formal@none@1@S@The oxidant stress-induced signaling resulted in an increased surface expression of a subset of CAMs, ICAM-1, E-selectin, and VCAM-1 in HUVEC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "stress-induced") (:form . "stress-induced")\n  (:end . 26) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "CAM") (:form . "CAMs") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ICAM-1") (:form . "ICAM-1") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1221.6) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011363@unknown@formal@none@1@S@The addition of oxygen radical scavenger enzymes (catalase, superoxide dismutase) and antioxidant (probucol) inhibited these events.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "oxygen") (:form . "oxygen") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "radical") (:form . "radical") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "superoxide") (:form . "superoxide") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "dismutase") (:form . "dismutase") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "antioxidant") (:form . "antioxidant") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "probucol") (:form . "probucol") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1221.7) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011364@unknown@formal@none@1@S@Additionally, preincubation of HUVEC with a synthetic peptide Arg-Gly-Asp (RGD) that prevents vWf-mediated adhesion of SS RBC reduced the surface expression of VCAM-1 and NF-kB activation.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "preincubation") (:form . "preincubation")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNP") (:stem . "Arg-Gly-Asp") (:form . "Arg-Gly-Asp") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RGD") (:form . "RGD") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "vwf-mediated") (:form . "vWf-mediated") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RBC") (:form . "RBC") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 166)\n  (:start . 160) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kB") (:form . "NF-kB") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 187)\n  (:start . 177) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1221.8) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011365@unknown@formal@none@1@S@Furthermore, SS RBC-induced oxidant stress resulted in a twofold increase in the transendothelial migration of both monocyte-like HL-60 cells and human peripheral blood monocytes, and approximately a sixfold increase in platelet-endothelial cell adhesion molecule-1 (PECAM-1) phosphorylation, each of which was blocked by protein kinase C inhibitor and antioxidants.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SS") (:form . "SS") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rbc-induced") (:form . "RBC-induced") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . 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5011366@unknown@formal@none@1@S@These results suggest that the adherence/contact of SS RBC to endothelial cells in large vessel can generate enhanced oxidant stress leading to increased adhesion and diapedesis of monocytes, as well as heightened adherence of SS reticulocytes, indicating that injury/activation of endothelium can contribute to vaso-occlusion in SCD.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adherence/contact") (:form . "adherence/contact")\n  (:end . 48) (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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"in") (:form . "in") (:end . 329) (:start . 327)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "SCD") (:form . "SCD") (:end . 333) (:start . 330)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 334) (:start . 333)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x1221.10.1) (:span 245 260))\n  ((:id . :x1221.10.2) (:span 14 21)))\n (:hscopes ((:id . :x1221.10.1) (:span 245 333))\n  ((:id . :x1221.10.2) (:span 14 333)))\n (:identifiers (:sid . :s1221.10) (:did . :|9808586|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011367@unknown@formal@none@1@S@Tobacco smoke induces coordinate activation of HSF and inhibition of NFkappaB in human monocytes: effects on TNFalpha release.@(((:tag . "NNP") (:stem . "Tobacco") (:form . "Tobacco") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "smoke") (:form . "smoke") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "coordinate") (:form . "coordinate") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HSF") (:form . "HSF") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1222.1) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011368@unknown@formal@none@1@S@Tobacco smoke (TS) exposure is a major risk factor for human disease, and macrophages of healthy smokers have a depressed capacity to release cytokines, including tumor necrosis factor (TNF)alpha.@(((:tag . "NNP") (:stem . "Tobacco") (:form . "Tobacco") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "smoke") (:form . "smoke") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TS") (:form . "TS") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 38) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "risk") (:form . "risk") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 60) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 68)\n  (:start . 61) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 85)\n  (:start . 74) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . "NNS") (:stem . "smoker") (:form . "smokers") (:end . 104)\n  (:start . 97) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "depress") (:form . "depressed") (:end . 121)\n  (:start . 112) (:id . 64))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 151)\n  (:start . 142) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 162)\n  (:start . 153) (:id . 70))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 177)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 184)\n  (:start . 178) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "TNF)alpha") (:form . "TNF)alpha") (:end . 195)\n  (:start . 186) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1222.2) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011370@unknown@formal@none@1@S@We determined whether Hsp70 induction by TS was mediated by the activation of the HS transcription factor, HSF.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "hsp70") (:form . "Hsp70") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ts") (:form . "TS") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 98) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HSF") (:form . "HSF") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1222.4.1) (:span 14 21)))\n (:hscopes ((:id . :x1222.4.1) (:span 14 110)))\n (:identifiers (:sid . :s1222.4) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011371@unknown@formal@none@1@S@HSF activation has been shown to inhibit NFkappaB.@(((:tag . "NNP") (:stem . "HSF") (:form . "HSF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1222.5) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011372@unknown@formal@none@1@S@Thus, we also determined the effects of TS on NFkappaB.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 24)\n  (:start . 14) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ts") (:form . "TS") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1222.6) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011373@unknown@formal@none@1@S@U937 cells and human peripheral blood monocytes were exposed to TS, binding activities of the respective transcription factors were analyzed, and Hsp70 expression and TNFalpha release were determined in parallel.@(((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ts") (:form . "TS") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 118) (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hsp70") (:form . "Hsp70") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 162)\n  (:start . 152) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 175)\n  (:start . 167) (:id . 68))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 183)\n  (:start . 176) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 199)\n  (:start . 189) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 72))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 211)\n  (:start . 203) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1222.7) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011374@unknown@formal@none@1@S@TS activated HSF, which was associated with Hsp70 overexpression and inhibition of NFkappaB binding activity and TNFalpha release.@(((:tag . "NN") (:stem . "ts") (:form . "TS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "HSF") (:form . "HSF") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hsp70") (:form . "Hsp70") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 64) (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1222.8) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011375@unknown@formal@none@1@S@The altered cytokine profile observed in smokers may relate to an HSF/Hsp70-mediated inhibition of NFkappaB activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "smoker") (:form . "smokers") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VB") (:stem . "relate") (:form . "relate") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "hsf/hsp70-mediated") (:form . "HSF/Hsp70-mediated")\n  (:end . 84) (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFkappaB") (:form . "NFkappaB") (:end . 107)\n  (:start . 99) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1222.9.1) (:span 49 52)))\n (:hscopes ((:id . :x1222.9.1) (:span 49 116)))\n (:identifiers (:sid . :s1222.9) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011376@unknown@formal@none@1@S@Copyright 1998 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1222.10) (:did . :|9813178|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011377@unknown@formal@none@1@S@Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules.@(((:tag . "JJ") (:stem . "transcriptional") (:form . "Transcriptional")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 26)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cross-talk") (:form . "cross-talk") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 83)\n  (:start . 76) (:id . 52))\n ((:tag . "NNP") (:stem . "STAT5") (:form . "STAT5") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 119)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1223.1) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011378@unknown@formal@none@1@S@The beta-casein promoter has been widely used to monitor the activation of STAT (signal transducer and activator of transcription)5 since STAT5 was originally found as a mediator of PRL-inducible beta-casein expression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "widely") (:form . "widely") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VB") (:stem . "monitor") (:form . "monitor") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 98)\n  (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "CD") (:stem . "transcription)5") (:form . "transcription)5")\n  (:end . 131) (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 164)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mediator") (:form . "mediator") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "prl-inducible") (:form . "PRL-inducible")\n  (:end . 195) (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 207)\n  (:start . 196) (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 218)\n  (:start . 208) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1223.2) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011380@unknown@formal@none@1@S@In this report, we describe the transcriptional regulation of the beta-casein gene by cytokines in T cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 47) (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1223.4) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011381@unknown@formal@none@1@S@We have found that the beta-casein gene is expressed in a cytotoxic T cell line, CTLL-2, in response to interleukin-2 (IL-2), which activates STAT5.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "CTLL-2") (:form . "CTLL-2") (:end . 87)\n  (:start . 81) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 100)\n  (:start . 92) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 117) (:start . 104) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 123) (:start . 119)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 124) (:start . 123)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 141)\n  (:start . 132) (:id . 69))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 147)\n  (:start . 142) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1223.5) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011382@unknown@formal@none@1@S@While IL-4 does not activate STAT5, it induces expression of STAT5-regulated genes in CTLL-2, i.e. beta-casein, a cytokine-inducible SH2-containing protein (CIS), and oncostatin M (OSM), suggesting that STAT6 activated by IL-4 substitutes for the function of STAT5 in T cells.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "stat5-regulated") (:form . "STAT5-regulated")\n  (:end . 76) (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "beta-casein") (:form . 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"T") (:end . 269) (:start . 268)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 275)\n  (:start . 270) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x1223.6.1) (:span 187 197)))\n (:ncues ((:id . :x1223.6.2) (:span 16 19)))\n (:hscopes ((:id . :x1223.6.1) (:span 187 275)))\n (:nscopes ((:id . :x1223.6.2) (:span 16 34)))\n (:identifiers (:sid . :s1223.6) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011383@unknown@formal@none@1@S@IL-2-induced beta-casein expression was enhanced by dexamethasone, and this synergistic effect of Dexamethasone requires the sequence between -155 and -193 in the beta-casein promoter.@(((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 48)\n  (:start . 40) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dexamethasone") (:form . "dexamethasone")\n  (:end . 65) (:start . 52) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 87)\n  (:start . 76) (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 111) (:start . 98) (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 120)\n  (:start . 112) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 133)\n  (:start . 125) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . "CD") (:stem . "-155") (:form . "-155") (:end . 146) (:start . 142)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-193") (:form . "-193") (:end . 155) (:start . 151)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 64))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 174)\n  (:start . 163) (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 183)\n  (:start . 175) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1223.7) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011384@unknown@formal@none@1@S@Coincidentally, a deletion of this region enhanced the IL-2-induced expression of beta-casein.@(((:tag . "RB") (:stem . "coincidentally") (:form . "Coincidentally")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1223.8) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011385@unknown@formal@none@1@S@Expression of an active form of Ras, Ras(G12V), suppressed the IL-2-induced beta-casein and OSM gene expression, and the negative effect of Ras is mediated by the region between -105 and -193 in the beta-casein promoter.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ras(G12V)") (:form . "Ras(G12V)") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "suppress") (:form . "suppressed") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 75)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "osm") (:form . "OSM") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 169)\n  (:start . 163) (:id . 71))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 177)\n  (:start . 170) (:id . 72))\n ((:tag . "CD") (:stem . "-105") (:form . "-105") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . "CD") (:stem . "-193") (:form . "-193") (:end . 191) (:start . 187)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 77))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 210)\n  (:start . 199) (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 219)\n  (:start . 211) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1223.9) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011386@unknown@formal@none@1@S@In apparent contradiction, expression of a dominant negative form of Ras, RasN17, also inhibited IL-2-induced activation of the promoter containing the minimal beta-casein STAT5 element as well as the promoters of CIS and OSM.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "contradiction") (:form . "contradiction")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RasN17") (:form . "RasN17") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "JJ") (:stem . "il-2-induced") (:form . "IL-2-induced") (:end . 109)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 147)\n  (:start . 137) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 171)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 177)\n  (:start . 172) (:id . 68))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 188) (:start . 186)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 196) (:start . 194)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 210)\n  (:start . 201) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "CIS") (:form . "CIS") (:end . 217) (:start . 214)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "OSM") (:form . "OSM") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1223.10) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011387@unknown@formal@none@1@S@In addition, Ras(G12V) complemented signaling by an erythropoietin receptor mutant defective in Ras activation and augmented the activation of the beta-casein promoter by the mutant erythropoietin receptor signaling, suggesting a possible role of Ras in Stat5-mediated gene expression.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "Ras(G12V)") (:form . "Ras(G12V)") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "complement") (:form . "complemented") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 66) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 110)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "beta-casein") (:form . "beta-casein") (:end . 158)\n  (:start . 147) (:id . 63))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 167)\n  (:start . 159) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 170) (:start . 168)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 181)\n  (:start . 175) (:id . 67))\n ((:tag . "NN") (:stem . "erythropoietin") (:form . "erythropoietin")\n  (:end . 196) (:start . 182) (:id . 68))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 205)\n  (:start . 197) (:id . 69))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 215)\n  (:start . 206) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 227)\n  (:start . 217) (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 229) (:start . 228)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 238)\n  (:start . 230) (:id . 74))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 243) (:start . 239)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 246) (:start . 244)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Ras") (:form . "Ras") (:end . 250) (:start . 247)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 253) (:start . 251)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "stat5-mediated") (:form . "Stat5-mediated")\n  (:end . 268) (:start . 254) (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 273) (:start . 269)\n  (:id . 80))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 284)\n  (:start . 274) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 285) (:start . 284)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1223.11.1) (:span 230 238))\n  ((:id . :x1223.11.2) (:span 217 227)))\n (:hscopes ((:id . :x1223.11.1) (:span 230 284))\n  ((:id . :x1223.11.2) (:span 217 284)))\n (:identifiers (:sid . :s1223.11) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011388@unknown@formal@none@1@S@These results collectively reveal a complex interaction of STAT5 with other signaling pathways and illustrate that regulation of gene expression requires integration of opposing signals.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "collectively") (:form . "collectively") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stat5") (:form . "STAT5") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "illustrate") (:form . "illustrate") (:end . 109)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 61))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 153)\n  (:start . 145) (:id . 62))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 165)\n  (:start . 154) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "opposing") (:form . "opposing") (:end . 177)\n  (:start . 169) (:id . 65))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 185)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1223.12) (:did . :|9817603|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011390@unknown@formal@none@1@S@Irrespective of the etiology, many kidney diseases result in inflammation and fibrosis of the tubulointerstitium, with the subsequent loss of renal function.@(((:tag . "JJ") (:stem . "irrespective") (:form . "Irrespective") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "etiology") (:form . "etiology") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kidney") (:form . "kidney") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "disease") (:form . "diseases") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "tubulointerstitium") (:form . "tubulointerstitium")\n  (:end . 112) (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1224.2) (:did . :|9819151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011391@unknown@formal@none@1@S@To initiate any disease process or for any disease process to progress, there must be changes in the transcription of genes within the affected tissue.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VB") (:stem . "progress") (:form . "progress") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 123)\n  (:start . 118) (:id . 63))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 143)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 150)\n  (:start . 144) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1224.3) (:did . :|9819151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011392@unknown@formal@none@1@S@The nuclear factor-kappa B (NF-kappaB) family of transcription factors regulates genes involved in inflammation, cell proliferation, and cell differentiation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor-kappa") (:form . "factor-kappa") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 111)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 157) (:start . 142) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1224.4) (:did . :|9819151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011393@unknown@formal@none@1@S@This review discusses the NF-kappaB transcription factor family in general and the association of NF-kappaB activation with cellular/molecular events of renal inflammation and fibrosis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "discuss") (:form . "discusses") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 107)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 118)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "cellular/molecular") (:form . "cellular/molecular")\n  (:end . 142) (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 149)\n  (:start . 143) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "renal") (:form . "renal") (:end . 158)\n  (:start . 153) (:id . 62))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 171)\n  (:start . 159) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fibrosis") (:form . "fibrosis") (:end . 184)\n  (:start . 176) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1224.5) (:did . :|9819151|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011394@unknown@formal@none@1@S@TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.@(((:tag . "NN") (:stem . "tal1") (:form . "TAL1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "lim-only") (:form . "LIM-only") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "RB") (:stem . "synergistically") (:form . "synergistically")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "retinaldehyde") (:form . "retinaldehyde")\n  (:end . 63) (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 77) (:start . 64) (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 79) (:start . 78)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 100)\n  (:start . 94) (:id . 53))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 106)\n  (:start . 101) (:id . 54))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 120) (:start . 107) (:id . 55))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 129)\n  (:start . 121) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 132) (:start . 130)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 139)\n  (:start . 133) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cofactor") (:form . "cofactors") (:end . 152)\n  (:start . 143) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "GATA3") (:form . "GATA3") (:end . 162)\n  (:start . 157) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1225.1) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011395@unknown@formal@none@1@S@Previously, we have shown that TAL1 and the LIM-only protein gene (LMO) are regularly coactivated in T-cell acute lymphoblastic leukemia (T-ALL).@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lim-only") (:form . "LIM-only") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "RB") (:stem . "regularly") (:form . "regularly") (:end . 85)\n  (:start . 76) (:id . 58))\n ((:tag . "VBN") (:stem . "coactivate") (:form . "coactivated") (:end . 97)\n  (:start . 86) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . "JJ") (:stem . "acute") (:form . "acute") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "JJ") (:stem . "lymphoblastic") (:form . "lymphoblastic")\n  (:end . 127) (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1225.2) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011396@unknown@formal@none@1@S@This observation is likely to relate to the findings that TAL1 and LMO are highly synergistic in T-cell tumorigenesis in double-transgenic mice.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "relate") (:form . "relate") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "JJ") (:stem . "synergistic") (:form . "synergistic") (:end . 93)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "tumorigenesis") (:form . "tumorigenesis")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "double-transgenic") (:form . "double-transgenic")\n  (:end . 138) (:start . 121) (:id . 62))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 143)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1225.3.1) (:span 20 26)))\n (:hscopes ((:id . :x1225.3.1) (:span 0 143)))\n (:identifiers (:sid . :s1225.3) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011397@unknown@formal@none@1@S@To understand the molecular mechanisms of functional synergy between TAL1 and LMO in tumorigenesis and transcriptional regulation, we tried to identify downstream target genes regulated by TAL1 and LMO by a subtractive PCR method.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "synergy") (:form . "synergy") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumorigenesis") (:form . "tumorigenesis")\n  (:end . 98) (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 118) (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 129)\n  (:start . 119) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "try") (:form . "tried") (:end . 139) (:start . 134)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 151)\n  (:start . 143) (:id . 63))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 162)\n  (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 169)\n  (:start . 163) (:id . 65))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 175)\n  (:start . 170) (:id . 66))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 185)\n  (:start . 176) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 193) (:start . 189)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 201) (:start . 198)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 204) (:start . 202)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 206) (:start . 205)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "subtractive") (:form . "subtractive") (:end . 218)\n  (:start . 207) (:id . 74))\n ((:tag . "NN") (:stem . "pcr") (:form . "PCR") (:end . 222) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 229)\n  (:start . 223) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1225.4) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011398@unknown@formal@none@1@S@One of the isolated genes, that for retinaldehyde dehydrogenase 2 (RALDH2), was regularly expressed in most of the T-ALL cell lines that coexpressed TAL1 and LMO.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "retinaldehyde") (:form . "retinaldehyde")\n  (:end . 49) (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "dehydrogenase") (:form . "dehydrogenase")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 79) (:start . 76)\n  (:id . 57))\n ((:tag . "RB") (:stem . "regularly") (:form . "regularly") (:end . 89)\n  (:start . 80) (:id . 58))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 131)\n  (:start . 126) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "coexpresse") (:form . "coexpressed") (:end . 148)\n  (:start . 137) (:id . 68))\n ((:tag . "NN") (:stem . "tal1") (:form . "TAL1") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 161) (:start . 158)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1225.5) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011400@unknown@formal@none@1@S@The RALDH2 transcripts in T-ALL were, however, mostly initiated within the second intron.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1225.7) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011401@unknown@formal@none@1@S@Promoter analysis revealed that a GATA site in a cryptic promoter in the second intron was essential and sufficient for the TAL1- and LMO-dependent transcriptional activation, and GATA3 binds to this site.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "GATA") (:form . "GATA") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cryptic") (:form . "cryptic") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TAL1-") (:form . "TAL1-") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "lmo-dependent") (:form . "LMO-dependent")\n  (:end . 147) (:start . 134) (:id . 65))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 163) (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 174)\n  (:start . 164) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 199) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 204) (:start . 200)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1225.8) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011402@unknown@formal@none@1@S@In addition, forced expression of GATA3 potentiated the induction of RALDH2 by TAL1 and LMO, and these three factors formed a complex in vivo.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "force") (:form . "forced") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "potentiate") (:form . "potentiated") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "VBD") (:stem . "form") (:form . "formed") (:end . 123)\n  (:start . 117) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 133)\n  (:start . 126) (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 141) (:start . 137)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1225.9) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011403@unknown@formal@none@1@S@Furthermore, a TAL1 mutant not binding to DNA also activated the transcription of RALDH2 in the presence of LMO and GATA3.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tal1") (:form . "TAL1") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GATA3") (:form . "GATA3") (:end . 121)\n  (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1225.10.1) (:span 27 30)))\n (:nscopes ((:id . :x1225.10.1) (:span 27 45)))\n (:identifiers (:sid . :s1225.10) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011404@unknown@formal@none@1@S@Collectively, we have identified the RALDH2 gene as a first example of direct transcriptional target genes regulated by TAL1 and LMO in T-ALL.@(((:tag . "RB") (:stem . "collectively") (:form . "Collectively") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 93) (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "T-ALL") (:form . "T-ALL") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1225.11) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011405@unknown@formal@none@1@S@In this case, TAL1 and LMO act as cofactors for GATA3 to activate the transcription of RALDH2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TAL1") (:form . "TAL1") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LMO") (:form . "LMO") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 30) (:start . 27)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cofactor") (:form . "cofactors") (:end . 43)\n  (:start . 34) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gata3") (:form . "GATA3") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 65)\n  (:start . 57) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "raldh2") (:form . "RALDH2") (:end . 93)\n  (:start . 87) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1225.12) (:did . :|9819382|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011406@unknown@formal@none@1@S@Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils.@(((:tag . "NNP") (:stem . "Granulocyte") (:form . "Granulocyte") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 30) (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 47)\n  (:start . 38) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "72-kda") (:form . "72-kDa") (:end . 56)\n  (:start . 50) (:id . 47))\n ((:tag . "NN") (:stem . "isoform") (:form . "isoform") (:end . 64)\n  (:start . 57) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stat3") (:form . "STAT3") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 94)\n  (:start . 83) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1226.1) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011407@unknown@formal@none@1@S@Granulocyte colony-stimulating factor (G-CSF) signaling involves activation of STATs, proteins that serve the dual function of signal transduction and activation of transcription.@(((:tag . "NNP") (:stem . "Granulocyte") (:form . "Granulocyte") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "colony-stimulating") (:form . "colony-stimulating")\n  (:end . 30) (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 44) (:start . 39)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 64)\n  (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STATs") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dual") (:form . "dual") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 146)\n  (:start . 134) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 161)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 178) (:start . 165) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1226.2) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011408@unknown@formal@none@1@S@We previously demonstrated that G-CSF activated a distinct Stat3-like protein in immature and mature normal myeloid cells, StatG.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "JJ") (:stem . "stat3-like") (:form . "Stat3-like") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "immature") (:form . "immature") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 115)\n  (:start . 108) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "StatG") (:form . "StatG") (:end . 128)\n  (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1226.3) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011410@unknown@formal@none@1@S@This investigation was undertaken to determine the composition of StatG in mature normal human myeloid cells, i.e. polymorphonuclear neutrophilic granulocytes (PMN).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "undertake") (:form . "undertaken") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "statg") (:form . "StatG") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 132) (:start . 115) (:id . 60))\n ((:tag . "JJ") (:stem . "neutrophilic") (:form . "neutrophilic") (:end . 145)\n  (:start . 133) (:id . 61))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 158)\n  (:start . 146) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1226.5) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011411@unknown@formal@none@1@S@These studies revealed that the major protein in extracts of PMN activated by G-CSF to bind the high-affinity serum-inducible element (hSIE) is a 72-kDa protein that cross-reacts with Stat3 monoclonal antibody, which we have designated Stat3gamma.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "G-CSF") (:form . "G-CSF") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "high-affinity") (:form . "high-affinity")\n  (:end . 109) (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "serum-inducible") (:form . "serum-inducible")\n  (:end . 125) (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "hSIE") (:form . "hSIE") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "72-kda") (:form . "72-kDa") (:end . 152)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "cross-react") (:form . "cross-reacts") (:end . 178)\n  (:start . 166) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 183) (:start . 179)\n  (:id . 71))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "JJ") (:stem . "monoclonal") (:form . "monoclonal") (:end . 200)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 209)\n  (:start . 201) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 216)\n  (:start . 211) (:id . 76))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 224) (:start . 220)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "designate") (:form . "designated") (:end . 235)\n  (:start . 225) (:id . 79))\n ((:tag . "NNP") (:stem . "Stat3gamma") (:form . "Stat3gamma") (:end . 246)\n  (:start . 236) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1226.6) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011412@unknown@formal@none@1@S@Stat3gamma is derived from Stat3alpha by limited proteolysis and lacks the carboxyl-terminal portion of Stat3alpha.@(((:tag . "NNP") (:stem . "Stat3gamma") (:form . "Stat3gamma") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Stat3alpha") (:form . "Stat3alpha") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "proteolysis") (:form . "proteolysis") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 92) (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 100)\n  (:start . 93) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Stat3alpha") (:form . "Stat3alpha") (:end . 114)\n  (:start . 104) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1226.7.1) (:span 65 70)))\n (:nscopes ((:id . :x1226.7.1) (:span 65 114)))\n (:identifiers (:sid . :s1226.7) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011413@unknown@formal@none@1@S@Because this region of Stat3alpha is involved in transcriptional activation, our findings suggest the possibility that Stat3gamma may be transcriptionally inactive and may compete with Stat3alpha for Stat3 binding sites in these terminally differentiated myeloid cells.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Stat3alpha") (:form . "Stat3alpha") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 97)\n  (:start . 90) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 113)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Stat3gamma") (:form . "Stat3gamma") (:end . 129)\n  (:start . 119) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 154) (:start . 137) (:id . 62))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 163)\n  (:start . 155) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 64))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 171) (:start . 168)\n  (:id . 65))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 179)\n  (:start . 172) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Stat3alpha") (:form . "Stat3alpha") (:end . 195)\n  (:start . 185) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 199) (:start . 196)\n  (:id . 69))\n ((:tag . "NN") (:stem . "stat3") (:form . "Stat3") (:end . 205)\n  (:start . 200) (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 213)\n  (:start . 206) (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 219)\n  (:start . 214) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 222) (:start . 220)\n  (:id . 73))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 228)\n  (:start . 223) (:id . 74))\n ((:tag . "RB") (:stem . "terminally") (:form . "terminally") (:end . 239)\n  (:start . 229) (:id . 75))\n ((:tag . "VBN") (:stem . "differentiate") (:form . "differentiated")\n  (:end . 254) (:start . 240) (:id . 76))\n ((:tag . "JJ") (:stem . "myeloid") (:form . "myeloid") (:end . 262)\n  (:start . 255) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 268)\n  (:start . 263) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x1226.8.1) (:span 168 171))\n  ((:id . :x1226.8.2) (:span 130 133)) ((:id . :x1226.8.3) (:span 102 113))\n  ((:id . :x1226.8.4) (:span 90 97)))\n (:hscopes ((:id . :x1226.8.1) (:span 168 268))\n  ((:id . :x1226.8.2) (:span 130 163)) ((:id . :x1226.8.3) (:span 102 268))\n  ((:id . :x1226.8.4) (:span 90 268)))\n (:identifiers (:sid . :s1226.8) (:did . :|9823774|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011414@unknown@formal@none@1@S@Differential effects of protein kinase C inhibitors on fibronectin-induced interleukin-beta gene transcription, protein synthesis and secretion in human monocytic cells.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "fibronectin-induced")\n  (:form . "fibronectin-induced") (:end . 74) (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-beta") (:form . "interleukin-beta")\n  (:end . 91) (:start . 75) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 96) (:start . 92)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 129)\n  (:start . 120) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 57))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 143)\n  (:start . 134) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 152)\n  (:start . 147) (:id . 60))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 162)\n  (:start . 153) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1227.1) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011415@unknown@formal@none@1@S@Human monocytic cells express interleukin-1beta (IL-1beta) when stimulated with the extracellular matrix glycoprotein, fibronectin (FN).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 47) (:start . 30) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 57)\n  (:start . 49) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 117)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fibronectin") (:form . "fibronectin") (:end . 130)\n  (:start . 119) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "FN") (:form . "FN") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1227.2) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011416@unknown@formal@none@1@S@Protein kinase C (PKC) activation is considered important for this process; however, the metabolic steps at which PKC acts upon to mediate the FN-induced IL-1beta response remain unclear.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 33)\n  (:start . 23) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "metabolic") (:form . "metabolic") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 138)\n  (:start . 131) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "fn-induced") (:form . "FN-induced") (:end . 153)\n  (:start . 143) (:id . 69))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 171)\n  (:start . 163) (:id . 71))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 178)\n  (:start . 172) (:id . 72))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 186)\n  (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1227.3.1) (:span 179 186)))\n (:hscopes ((:id . :x1227.3.1) (:span 85 186)))\n (:identifiers (:sid . :s1227.3) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011417@unknown@formal@none@1@S@We performed an analysis of the mechanisms by which two PKC inhibitors, Calphostin C and Staurosporine, prevent the FN-induced IL-1beta response.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Calphostin") (:form . "Calphostin") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Staurosporine") (:form . "Staurosporine")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "prevent") (:form . "prevent") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "fn-induced") (:form . "FN-induced") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1227.4) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011418@unknown@formal@none@1@S@Both inhibitors blocked the secretion of IL-1beta protein into the media of peripheral blood mononuclear cells exposed to FN.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "medium") (:form . "media") (:end . 72)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 104)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "FN") (:form . "FN") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1227.5) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011420@unknown@formal@none@1@S@To determine the mechanisms responsible for these differences, we turned to human U937 promonocytic cells.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "turn") (:form . "turned") (:end . 72) (:start . 66)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1227.7) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011421@unknown@formal@none@1@S@U937 cells transfected with the human full-length IL-1beta promoter connected to a luciferase reporter gene were submitted to transcription assays, Northern blotting, and DNA electrophoresis mobility gel shift assays.@(((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "full-length") (:form . "full-length") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "VBN") (:stem . "connect") (:form . "connected") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 102)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "submit") (:form . "submitted") (:end . 122)\n  (:start . 113) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 60))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 146)\n  (:start . 140) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "electrophoresis") (:form . "electrophoresis")\n  (:end . 190) (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 199)\n  (:start . 191) (:id . 69))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 209)\n  (:start . 204) (:id . 71))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 216)\n  (:start . 210) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1227.8) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011422@unknown@formal@none@1@S@These studies revealed that Calphostin C inhibited the nuclear translocation of the transcription factor activator protein-1 (AP-1) which is considered necessary for FN induction of IL-1beta gene transcription, and prevented the transcription of the IL-1beta gene.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Calphostin") (:form . "Calphostin") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 104)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 114)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 124)\n  (:start . 115) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 137)\n  (:start . 132) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 151)\n  (:start . 141) (:id . 63))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 161)\n  (:start . 152) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 65))\n ((:tag . "NN") (:stem . "fn") (:form . "FN") (:end . 168) (:start . 166)\n  (:id . 66))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 190)\n  (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 195) (:start . 191)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 209) (:start . 196) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 224)\n  (:start . 215) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 242) (:start . 229) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 258)\n  (:start . 250) (:id . 79))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 263) (:start . 259)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1227.9) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011423@unknown@formal@none@1@S@In contrast, Staurosporine alone induced AP-1 translocation and stimulation of the gene.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Staurosporine") (:form . "Staurosporine")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1227.10) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011424@unknown@formal@none@1@S@Overall, our data indicate that Calphostin C prevents the transcription of the IL-1beta gene thereby inhibiting protein synthesis.@(((:tag . "RB") (:stem . "overall") (:form . "Overall") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Calphostin") (:form . "Calphostin") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 71) (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 129)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1227.11.1) (:span 18 31)))\n (:hscopes ((:id . :x1227.11.1) (:span 18 129)))\n (:identifiers (:sid . :s1227.11) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011425@unknown@formal@none@1@S@Based on the high specificity of this compound for PKC, we conclude that PKC is necessary for FN-induced IL-1beta protein production.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "compound") (:form . "compound") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PKC") (:form . "PKC") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 89)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "fn-induced") (:form . "FN-induced") (:end . 104)\n  (:start . 94) (:id . 60))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 113)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1227.12) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011426@unknown@formal@none@1@S@In contrast, Staurosporine prevented secretion of IL-1beta by unknown mechanisms.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Staurosporine") (:form . "Staurosporine")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x1227.13.1) (:span 62 69)))\n (:hscopes ((:id . :x1227.13.1) (:span 62 80)))\n (:identifiers (:sid . :s1227.13) (:did . :|9824485|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011427@unknown@formal@none@1@S@Membrane-associated lymphotoxin on natural killer cells activates endothelial cells via an NF-kappaB-dependent pathway.@(((:tag . "JJ") (:stem . "membrane-associated")\n  (:form . "Membrane-associated") (:end . 19) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "lymphotoxin") (:form . "lymphotoxin") (:end . 31)\n  (:start . 20) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 42)\n  (:start . 35) (:id . 45))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 49)\n  (:start . 43) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 55) (:start . 50)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 65)\n  (:start . 56) (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 77)\n  (:start . 66) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 50))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 87) (:start . 84)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 110) (:start . 91) (:id . 53))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 118)\n  (:start . 111) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1228.1) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011428@unknown@formal@none@1@S@BACKGROUND: Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation.@(((:tag . "NN") (:stem . "background") (:form . "BACKGROUND") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "xenotransplantation")\n  (:form . "xenotransplantation") (:end . 82) (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 86) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 99)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "graft") (:form . "graft") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "infiltration") (:form . "infiltration") (:end . 118)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 131)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 138)\n  (:start . 132) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 142) (:start . 140)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 174)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 179) (:start . 175)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 191)\n  (:start . 180) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 196) (:start . 192)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 200) (:start . 198)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 201) (:start . 200)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 212)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1228.2) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011430@unknown@formal@none@1@S@In this study, we used the NK cell line NK92 to define the molecular and cellular basis of NK cell-mediated EC activation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 50))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 39) (:start . 35)\n  (:id . 51))\n ((:tag . "NN") (:stem . "nk92") (:form . "NK92") (:end . 44) (:start . 40)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 53))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 54)\n  (:start . 48) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 68)\n  (:start . 59) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 81)\n  (:start . 73) (:id . 58))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 93) (:start . 91)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "cell-mediated") (:form . "cell-mediated")\n  (:end . 107) (:start . 94) (:id . 62))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 121)\n  (:start . 111) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1228.4) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011431@unknown@formal@none@1@S@METHODS: EC were transfected with either reporter constructs containing the luciferase gene driven either by E-selectin or interleukin (IL)-8 promoters or a synthetic NF-kappaB-dependent promoter.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 28)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 119)\n  (:start . 109) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 134)\n  (:start . 123) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "IL)-8") (:form . "IL)-8") (:end . 141)\n  (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 151)\n  (:start . 142) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 154) (:start . 152)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 166)\n  (:start . 157) (:id . 66))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 186) (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 195)\n  (:start . 187) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1228.5) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011432@unknown@formal@none@1@S@In addition, a dominant-negative mutant tumor necrosis factor receptor I (TNFRI) expression vector was co-transfected in inhibition studies.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 32) (:start . 15) (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "co-transfecte") (:form . "co-transfected")\n  (:end . 117) (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1228.6) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011433@unknown@formal@none@1@S@Forty-eight hours after transfection, EC were stimulated with NK cells or NK cell membrane extracts for 7 hr and activation was measured by a luciferase assay.@(((:tag . "CD") (:stem . "forty-eight") (:form . "Forty-eight") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 36)\n  (:start . 24) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hr") (:form . "hr") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "luciferase") (:form . "luciferase") (:end . 152)\n  (:start . 142) (:id . 67))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1228.7) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011434@unknown@formal@none@1@S@RESULTS: Co-culture of NK cells with transfected EC enhanced E-selectin, IL-8, and NF-kappaB-dependent promoter activity.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Co-culture") (:form . "Co-culture") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "nf-kappab-dependent")\n  (:form . "NF-kappaB-dependent") (:end . 102) (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1228.8) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011435@unknown@formal@none@1@S@NK cell membrane extracts retained the capacity to activate EC and induced nuclear translocation of NF-kappaB (p50 and p65).@(((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "retain") (:form . "retained") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 96) (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1228.9) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011436@unknown@formal@none@1@S@Western blotting of NK cell and membrane extracts detected the presence of Lymphotoxin-alpha (LTalpha) but not tumor necrosis factor-alpha.@(((:tag . "NNP") (:stem . "Western") (:form . "Western") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Lymphotoxin-alpha") (:form . "Lymphotoxin-alpha")\n  (:end . 92) (:start . 75) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LTalpha") (:form . "LTalpha") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 138)\n  (:start . 126) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1228.10.1) (:span 107 110)))\n (:nscopes ((:id . :x1228.10.1) (:span 107 138)))\n (:identifiers (:sid . :s1228.10) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011437@unknown@formal@none@1@S@Furthermore, LTalpha was secreted in NK:EC co-cultures.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "LTalpha") (:form . "LTalpha") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NK:EC") (:form . "NK:EC") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "co-culture") (:form . "co-cultures") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1228.11) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011438@unknown@formal@none@1@S@Co-transfection with dominant-negative mutant TNFRI inhibited EC activation by NK cell membrane extracts and by NK cells by 80% and 47%, respectively.@(((:tag . "NN") (:stem . "co-transfection") (:form . "Co-transfection")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 38) (:start . 21) (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 45)\n  (:start . 39) (:id . 45))\n ((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 51) (:start . 46)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 61)\n  (:start . 52) (:id . 47))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 64) (:start . 62)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 149)\n  (:start . 137) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1228.12) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011440@unknown@formal@none@1@S@CONCLUSIONS: Human NK cell membrane-bound LT signals across species via TNFRI, leading to NF-kappaB nuclear translocation and transcription of E-selectin and IL-8, which results in EC activation.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "membrane-bound") (:form . "membrane-bound")\n  (:end . 41) (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "lt") (:form . "LT") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 121) (:start . 108) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 153)\n  (:start . 143) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-8") (:form . "IL-8") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1228.14) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011441@unknown@formal@none@1@S@The discrepancy in the degree of inhibition by membrane extracts and NK cells with mutant TNFRI suggests that additional pathways are utilized by NK cells to activate EC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "discrepancy") (:form . "discrepancy") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "nk") (:form . "NK") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NNP") (:stem . "TNFRI") (:form . "TNFRI") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 120)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 129)\n  (:start . 121) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "utilize") (:form . "utilized") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NK") (:form . "NK") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 166)\n  (:start . 158) (:id . 68))\n ((:tag . "NNP") (:stem . "EC") (:form . "EC") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1228.15.1) (:span 96 104)))\n (:hscopes ((:id . :x1228.15.1) (:span 96 169)))\n (:identifiers (:sid . :s1228.15) (:did . :|9825820|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011442@unknown@formal@none@1@S@Cloning of ARE-containing genes by AU-motif-directed display.@(((:tag . "NN") (:stem . "cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "are-containing") (:form . "ARE-containing")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "au-motif-directed") (:form . "AU-motif-directed")\n  (:end . 52) (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "display") (:form . "display") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1229.1) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011443@unknown@formal@none@1@S@A procedure suitable for cloning labile mRNAs that contain AU motifs is presented (AU-DD).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "suitable") (:form . "suitable") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "clone") (:form . "cloning") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "labile") (:form . "labile") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "mrna") (:form . "mRNAs") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "AU") (:form . "AU") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AU-DD") (:form . "AU-DD") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1229.2) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011444@unknown@formal@none@1@S@These motifs are regulatory sequences within the so-called AU-rich elements (AREs) often found in 3' untranslated regions of genes such as cytokines, proto-oncogenes, and transcription factors.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "au-rich") (:form . "AU-rich") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ARE") (:form . "AREs") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "'") (:form . "'") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "untranslated") (:form . "untranslated") (:end . 113)\n  (:start . 101) (:id . 60))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "proto-oncogene") (:form . "proto-oncogenes")\n  (:end . 165) (:start . 150) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 184) (:start . 171) (:id . 71))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 192)\n  (:start . 185) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1229.3) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011445@unknown@formal@none@1@S@AU-DD is an AU-motif-directed differential display that permits the identification of ARE-containing genes differentially expressed after cell activation.@(((:tag . "NNP") (:stem . "AU-DD") (:form . "AU-DD") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "au-motif-directed") (:form . "AU-motif-directed")\n  (:end . 29) (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "display") (:form . "display") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "permit") (:form . "permits") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 82) (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "are-containing") (:form . "ARE-containing")\n  (:end . 100) (:start . 86) (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 106)\n  (:start . 101) (:id . 54))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 121) (:start . 107) (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 131)\n  (:start . 122) (:id . 56))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 137)\n  (:start . 132) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 142) (:start . 138)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 153)\n  (:start . 143) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1229.4) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011446@unknown@formal@none@1@S@It has been applied to peripheral blood monocytes and a T cell clone to isolate 59 cDNA fragments associated to activation.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "VB") (:stem . "isolate") (:form . "isolate") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "CD") (:stem . "59") (:form . "59") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 97)\n  (:start . 88) (:id . 59))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1229.5) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011447@unknown@formal@none@1@S@Fourteen percent of isolated fragments belong to already known genes that certainly are cytokines and transduction/transcription factors.@(((:tag . "CD") (:stem . "fourteen") (:form . "Fourteen") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "percent") (:form . "percent") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "certainly") (:form . "certainly") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transduction/transcription")\n  (:form . "transduction/transcription") (:end . 128) (:start . 102)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 136)\n  (:start . 129) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1229.6) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011448@unknown@formal@none@1@S@The remaining 86% correspond to unknown genes of which 92% have been confirmed to be differentially expressed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "86") (:form . "86") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "correspond") (:form . "correspond") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "CD") (:stem . "92") (:form . "92") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 99) (:start . 85) (:id . 59))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 109)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1229.7) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011450@unknown@formal@none@1@S@Copyright 1998 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1229.9) (:did . :|9828130|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011451@unknown@formal@none@1@S@Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "tnf-") (:form . "TNF-") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytokine-receptor") (:form . "cytokine-receptor")\n  (:end . 61) (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "VBP") (:stem . "target") (:form . "target") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "cis-element") (:form . "cis-element") (:end . 98)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IFN") (:form . "IFN") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1230.1) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011452@unknown@formal@none@1@S@CD40 activation of B cells is strongly influenced by the presence of cytokines.@(((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1230.2) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011453@unknown@formal@none@1@S@However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interplay") (:form . "interplay") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "VBN") (:stem . "delineate") (:form . "delineated") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1230.3.1) (:span 81 103)))\n (:hscopes ((:id . :x1230.3.1) (:span 9 103)))\n (:identifiers (:sid . :s1230.3) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011454@unknown@formal@none@1@S@IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines.@(((:tag . "NN") (:stem . "ifn") (:form . "IFN") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1230.4) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011455@unknown@formal@none@1@S@We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "VBP") (:stem . "target") (:form . "target") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "cis-acting") (:form . "cis-acting") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 125)\n  (:start . 120) (:id . 64))\n ((:tag . "JJ") (:stem . "gamma-activated") (:form . "gamma-activated")\n  (:end . 141) (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1230.5) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011456@unknown@formal@none@1@S@Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV.@(((:tag . "NN") (:stem . "targeting") (:form . "Targeting") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IRF-1") (:form . "IRF-1") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GAS") (:form . "GAS") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "confine") (:form . "confined") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "extend") (:form . "extends") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "mimic") (:form . "mimic") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cd40") (:form . "CD40") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 124)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 132)\n  (:start . 125) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 148)\n  (:start . 139) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1230.6.1) (:span 30 33)))\n (:nscopes ((:id . :x1230.6.1) (:span 0 65)))\n (:identifiers (:sid . :s1230.6) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011457@unknown@formal@none@1@S@In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains Rel proteins, specifically p50 and p65.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "irf-1") (:form . "IRF-1") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "gas-binding") (:form . "GAS-binding") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CD40") (:form . "CD40") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 136)\n  (:start . 128) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 150)\n  (:start . 138) (:id . 67))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1230.7.1) (:span 108 110)))\n (:hscopes ((:id . :x1230.7.1) (:span 91 114)))\n (:identifiers (:sid . :s1230.7) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011458@unknown@formal@none@1@S@In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "simultaneous") (:form . "simultaneous") (:end . 28)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cd40l") (:form . "CD40L") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IFN-gamma") (:form . "IFN-gamma") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "rel/stat") (:form . "Rel/STAT") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 145)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1230.8.1) (:span 91 94)))\n (:nscopes ((:id . :x1230.8.1) (:span 91 145)))\n (:identifiers (:sid . :s1230.8) (:did . :|9834081|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011460@unknown@formal@none@1@S@Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stat1") (:form . "STAT1") (:end . 47) (:start . 42)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 55)\n  (:start . 48) (:id . 53))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 62)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 79)\n  (:start . 68) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "noninvasive") (:form . "noninvasive") (:end . 94)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 148)\n  (:start . 136) (:id . 66))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 169)\n  (:start . 161) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 171) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1231.1) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011461@unknown@formal@none@1@S@Activation of T lymphocytes by Ags or cytokines results in translocation of the transcription factors NF-kappa B, AP-1, NFAT, and STAT from the cytoplasm into the nucleus.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "ag") (:form . "Ags") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "translocation") (:form . "translocation")\n  (:end . 72) (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 93) (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "STAT") (:form . "STAT") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 153)\n  (:start . 144) (:id . 68))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 170)\n  (:start . 163) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1231.2) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011462@unknown@formal@none@1@S@The first step in the nuclear import process is recognition of a nuclear localization sequence (NLS) within the karyophilic protein by a cytoplasmic receptor such as the importin (karyopherin)-alpha subunit.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nls") (:form . "NLS") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "karyophilic") (:form . "karyophilic") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 148)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "importin") (:form . "importin") (:end . 178)\n  (:start . 170) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "NN") (:stem . "karyopherin)-alpha") (:form . "karyopherin)-alpha")\n  (:end . 198) (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 206)\n  (:start . 199) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1231.3) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011463@unknown@formal@none@1@S@The NLSs of NF-kappa B, AP-1, and NFAT differ and the NLS of STAT1 has not yet been identified.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "NLS") (:form . "NLSs") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 38) (:start . 34)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differ") (:form . "differ") (:end . 45)\n  (:start . 39) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nls") (:form . "NLS") (:end . 57) (:start . 54)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 66) (:start . 61)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 74) (:start . 71)\n  (:id . 59))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 78) (:start . 75)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 83) (:start . 79)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 94)\n  (:start . 84) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1231.4.1) (:span 71 74)))\n (:nscopes ((:id . :x1231.4.1) (:span 50 94)))\n (:identifiers (:sid . :s1231.4) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011464@unknown@formal@none@1@S@Herein we demonstrate that the inducible nuclear import of NF-kappa B, AP-1, NFAT, and STAT1 in Jurkat T lymphocytes is significantly inhibited by a cell-permeable peptide carrying the NLS of the NF-kappa B p50 subunit.@(((:tag . "RB") (:stem . "herein") (:form . "Herein") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AP-1") (:form . "AP-1") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "STAT1") (:form . "STAT1") (:end . 92) (:start . 87)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 102)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 116)\n  (:start . 105) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 133) (:start . 120) (:id . 65))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 143)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cell-permeable") (:form . "cell-permeable")\n  (:end . 163) (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 180)\n  (:start . 172) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 72))\n ((:tag . "NN") (:stem . "nls") (:form . "NLS") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 204)\n  (:start . 196) (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 210) (:start . 207)\n  (:id . 78))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 218)\n  (:start . 211) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1231.5) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011465@unknown@formal@none@1@S@NLS peptide-mediated disruption of the nuclear import of these transcription factors results in inhibition of I kappa B alpha and IL-2 gene expression, processes dependent on NF-kappa B or the combination of NF-kappa B, AP-1, and NFAT.@(((:tag . "NNP") (:stem . "NLS") (:form . "NLS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "peptide-mediated") (:form . "peptide-mediated")\n  (:end . 20) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "disruption") (:form . "disruption") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "import") (:form . "import") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 106)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "kappa") (:form . "kappa") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 171)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 183)\n  (:start . 175) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 204)\n  (:start . 193) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 216)\n  (:start . 208) (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 224) (:start . 220)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 229) (:start . 226)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 234) (:start . 230)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s1231.6) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011466@unknown@formal@none@1@S@Further, we show that inhibitory NLS peptide interacts in vitro with a cytoplasmic NLS receptor complex comprised of the Rch1/importin (karyopherin)-beta heterodimer expressed in Jurkat T cells.@(((:tag . "RB") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "nls") (:form . "NLS") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "NNP") (:stem . "NLS") (:form . "NLS") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "VBN") (:stem . "comprise") (:form . "comprised") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Rch1/importin") (:form . "Rch1/importin")\n  (:end . 134) (:start . 121) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "karyopherin)-beta") (:form . "karyopherin)-beta")\n  (:end . 153) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 165)\n  (:start . 154) (:id . 65))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 175)\n  (:start . 166) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 185)\n  (:start . 179) (:id . 68))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 193)\n  (:start . 188) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1231.7) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011467@unknown@formal@none@1@S@Taken together, these data indicate that the inducible nuclear import of NF-kappa B, AP-1, NFAT, and STAT1 in Jurkat T cells can be regulated by NLS peptide delivered noninvasively to the cytoplasm of Jurkat T cells to target members of the importin (karyopherin)-alpha beta NLS receptor complex.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . 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"beta") (:end . 274) (:start . 270)\n  (:id . 90))\n ((:tag . "NN") (:stem . "nls") (:form . "NLS") (:end . 278) (:start . 275)\n  (:id . 91))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 287)\n  (:start . 279) (:id . 92))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 295)\n  (:start . 288) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x1231.8.1) (:span 27 40)))\n (:hscopes ((:id . :x1231.8.1) (:span 27 295)))\n (:identifiers (:sid . :s1231.8) (:did . :|9834092|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011468@unknown@formal@none@1@S@Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.@(((:tag . "JJ") (:stem . "epithelial") (:form . "Epithelial") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cell-initiated") (:form . "cell-initiated")\n  (:end . 25) (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 38)\n  (:start . 26) (:id . 44))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 44) (:start . 39)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 59) (:start . 55)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 82)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "amebic") (:form . "amebic") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "intestine") (:form . "intestine") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1232.1) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011470@unknown@formal@none@1@S@The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "aim") (:form . "aims") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 37)\n  (:start . 31) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 71)\n  (:start . 59) (:id . 55))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 94)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "amebiasis") (:form . "amebiasis") (:end . 125)\n  (:start . 116) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 156)\n  (:start . 146) (:id . 69))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 167)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "initiate") (:form . "initiating") (:end . 186)\n  (:start . 176) (:id . 73))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 191) (:start . 187)\n  (:id . 74))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 200)\n  (:start . 192) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1232.3) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011471@unknown@formal@none@1@S@METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.@(((:tag . "NNS") (:stem . "methods") (:form . "METHODS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "histolytica") (:form . "histolytica") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "xenograft") (:form . "xenografts") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 99)\n  (:start . 91) (:id . 55))\n ((:tag . "JJ") (:stem . "immunodeficient") (:form . "immunodeficient")\n  (:end . 115) (:start . 100) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "scid-hu-int") (:form . "SCID-HU-INT") (:end . 128)\n  (:start . 117) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 134)\n  (:start . 130) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1232.4) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011472@unknown@formal@none@1@S@Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 55)\n  (:start . 46) (:id . 47))\n ((:tag . "TO") (:stem . 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5011473@unknown@formal@none@1@S@RESULTS: Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.@(((:tag . "NNS") (:stem . "results") (:form . "RESULTS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Administration") (:form . "Administration")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 56) (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 100)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "1beta") (:form . "1beta") (:end . 106)\n  (:start . 101) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 122)\n  (:start . 111) (:id . 57))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 138)\n  (:start . 128) (:id . 60))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 149)\n  (:start . 139) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 155)\n  (:start . 150) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 169)\n  (:start . 160) (:id . 64))\n ((:tag . "NN") (:stem . "neutrophil") (:form . "neutrophil") (:end . 180)\n  (:start . 170) (:id . 65))\n ((:tag . "NN") (:stem . "influx") (:form . "influx") (:end . 187)\n  (:start . 181) (:id . 66))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 192) (:start . 188)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "histolytica-infected")\n  (:form . "histolytica-infected") (:end . 220) (:start . 200) (:id . 70))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 231)\n  (:start . 221) (:id . 71))\n ((:tag . "NNS") (:stem . "xenograft") (:form . "xenografts") (:end . 242)\n  (:start . 232) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1232.6) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011474@unknown@formal@none@1@S@Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU- INT mice blocked the increase in intestinal permeability observed with amebic infection.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gut") (:form . "gut") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "antisense") (:form . "antisense") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 76) (:start . 61) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 108)\n  (:start . 97) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 113) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "scid-hu-") (:form . "SCID-HU-") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "NNP") (:stem . "INT") (:form . "INT") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 131)\n  (:start . 127) (:id . 60))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 139)\n  (:start . 132) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 152)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "intestinal") (:end . 166)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "permeability") (:form . "permeability") (:end . 179)\n  (:start . 167) (:id . 66))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 188)\n  (:start . 180) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "amebic") (:form . "amebic") (:end . 200)\n  (:start . 194) (:id . 69))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 210)\n  (:start . 201) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1232.7) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011475@unknown@formal@none@1@S@CONCLUSIONS: Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.@(((:tag . "NNS") (:stem . "conclusions") (:form . "CONCLUSIONS") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intestinal") (:form . "Intestinal") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "initiate") (:form . "initiate") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "JJ") (:stem . "neutrophil-mediated")\n  (:form . "neutrophil-mediated") (:end . 109) (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 116)\n  (:start . 110) (:id . 54))\n ((:tag . "NN") (:stem . "damage") (:form . "damage") (:end . 123)\n  (:start . 117) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 135)\n  (:start . 127) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 58))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 141) (:start . 139)\n  (:id . 59))\n ((:tag . "NN") (:stem . "histolytica") (:form . "histolytica") (:end . 153)\n  (:start . 142) (:id . 60))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 163)\n  (:start . 154) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 164) (:start . 163)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 169) (:start . 165)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 182)\n  (:start . 170) (:id . 64))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 190)\n  (:start . 183) (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 194) (:start . 191)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 197) (:start . 195)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 205)\n  (:start . 198) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 208) (:start . 206)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 219)\n  (:start . 209) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 237) (:start . 224) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 240) (:start . 238)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 246)\n  (:start . 241) (:id . 74))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 256)\n  (:start . 247) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 259) (:start . 257)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 267)\n  (:start . 260) (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 274)\n  (:start . 268) (:id . 78))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 281)\n  (:start . 275) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1232.8) (:did . :|9834272|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011476@unknown@formal@none@1@S@In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.@(((:tag . "FW") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "metalloproteinases-1")\n  (:form . "metalloproteinases-1") (:end . 100) (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1233.1) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011477@unknown@formal@none@1@S@Cellular pathways for induction of programmed cell death (PCD) have been identified, but little is known about specific extracellular matrix processes that may affect apoptosis along those pathways.@(((:tag . "JJ") (:stem . "cellular") (:form . "Cellular") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PCD") (:form . "PCD") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 133) (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 176)\n  (:start . 167) (:id . 69))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 188)\n  (:start . 183) (:id . 71))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 197)\n  (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1233.2.1) (:span 156 159)))\n (:hscopes ((:id . :x1233.2.1) (:span 156 197)))\n (:identifiers (:sid . :s1233.2) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011478@unknown@formal@none@1@S@In this study, a series of Burkitt's lymphoma (BL) cell lines were assayed for their expression of tissue inhibitor of metalloproteinases (TIMP)-1.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 45)\n  (:start . 37) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "BL") (:form . "BL") (:end . 49) (:start . 47)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 55) (:start . 51)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 61) (:start . 56)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 74)\n  (:start . 67) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 84)\n  (:start . 79) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 95)\n  (:start . 85) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 105)\n  (:start . 99) (:id . 63))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 115)\n  (:start . 106) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "metalloproteinas") (:form . "metalloproteinases")\n  (:end . 137) (:start . 119) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TIMP)-1") (:form . "TIMP)-1") (:end . 146)\n  (:start . 139) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1233.3) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011480@unknown@formal@none@1@S@Furthermore, recombinant TIMP-1, but not TIMP-2 or a synthetic metalloproteinase inhibitor (BB-94), confers resistance to apoptosis induced by both CD95-dependent and -independent (cold shock, serum deprivation, and gamma-radiation) pathways in TIMP-1-negative BL lines.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "timp-2") (:form . "TIMP-2") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "metalloproteinase") (:form . "metalloproteinase")\n  (:end . 80) (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bb-94") (:form . "BB-94") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "confer") (:form . "confers") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 139)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cd95-dependent") (:form . "CD95-dependent")\n  (:end . 162) (:start . 148) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "-independent") (:form . "-independent") (:end . 179)\n  (:start . 167) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cold") (:form . "cold") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 191)\n  (:start . 186) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 198)\n  (:start . 193) (:id . 73))\n ((:tag . "NN") (:stem . "deprivation") (:form . "deprivation") (:end . 210)\n  (:start . 199) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gamma-radiation") (:form . "gamma-radiation")\n  (:end . 231) (:start . 216) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 241)\n  (:start . 233) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 244) (:start . 242)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "timp-1-negative") (:form . "TIMP-1-negative")\n  (:end . 260) (:start . 245) (:id . 81))\n ((:tag . "NNP") (:stem . "BL") (:form . "BL") (:end . 263) (:start . 261)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 269)\n  (:start . 264) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1233.5.1) (:span 48 50)))\n (:ncues ((:id . :x1233.5.2) (:span 37 40)))\n (:hscopes ((:id . :x1233.5.1) (:span 41 98)))\n (:nscopes ((:id . :x1233.5.2) (:span 37 98)))\n (:identifiers (:sid . :s1233.5) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011481@unknown@formal@none@1@S@TIMP-1 suppression of PCD is not due to metalloproteinase inhibition, as reduction and alkylation of the TIMP-1 did not abolish this activity.@(((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PCD") (:form . "PCD") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "metalloproteinase") (:form . "metalloproteinase")\n  (:end . 57) (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "alkylation") (:form . "alkylation") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "VB") (:stem . "abolish") (:form . "abolish") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1233.6.1) (:span 116 119))\n  ((:id . :x1233.6.2) (:span 29 32)))\n (:nscopes ((:id . :x1233.6.1) (:span 116 141))\n  ((:id . :x1233.6.2) (:span 29 68)))\n (:identifiers (:sid . :s1233.6) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011482@unknown@formal@none@1@S@Retroviral induction of TIMP-1 not only resulted in cell survival but also in continued DNA synthesis for up to 5 d in the absence of serum, while controls underwent apoptosis.@(((:tag . "JJ") (:stem . "retroviral") (:form . "Retroviral") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "continued") (:form . "continued") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 68))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 146)\n  (:start . 141) (:id . 69))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 155)\n  (:start . 147) (:id . 70))\n ((:tag . "VBD") (:stem . "undergo") (:form . "underwent") (:end . 165)\n  (:start . 156) (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 175)\n  (:start . 166) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1233.7) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011483@unknown@formal@none@1@S@This resistance to apoptosis is reversed by anti-TIMP-1 antibodies, demonstrating that secreted TIMP-1 is active in blocking apoptosis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "resistance") (:form . "resistance") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reverse") (:form . "reversed") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-timp-1") (:form . "anti-TIMP-1") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 81)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1233.8) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011484@unknown@formal@none@1@S@Furthermore, TIMP-1 upregulation induced expression of Bcl-XL but not Bcl-2 as well as decreased NF-kappaB activity as compared with controls.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "upregulation") (:form . "upregulation") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Bcl-XL") (:form . "Bcl-XL") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "control") (:form . "controls") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x1233.9.1) (:span 66 69)))\n (:nscopes ((:id . :x1233.9.1) (:span 66 75)))\n (:identifiers (:sid . :s1233.9) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011485@unknown@formal@none@1@S@These results demonstrate that TIMP-1 suppresses apoptosis in B cells and suggests a novel activity for TIMP-1 in tissue homeostasis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 48)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "timp-1") (:form . "TIMP-1") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 132)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1233.10.1) (:span 74 82)))\n (:hscopes ((:id . :x1233.10.1) (:span 74 132)))\n (:identifiers (:sid . :s1233.10) (:did . :|9835626|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011486@unknown@formal@none@1@S@Interleukin-12 expression in B cells by transformation with Epstein-Barr virus.@(((:tag . "NN") (:stem . "interleukin-12") (:form . "Interleukin-12")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 30) (:start . 29)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 54) (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 72)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1234.1) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011487@unknown@formal@none@1@S@Although interleukin (IL)-12 was originally purified from an Epstein-Barr (EBV)-transformed B cell line and the high correlation of EBV infection and IL-12 expression has been suggested, no study has reported whether EBV infection is directly linked to IL-12 expression.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "IL)-12") (:form . "IL)-12") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "purify") (:form . "purified") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "EBV)-transformed") (:form . "EBV)-transformed")\n  (:end . 91) (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 128)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 155)\n  (:start . 150) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 166)\n  (:start . 156) (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 185)\n  (:start . 176) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 70))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 195)\n  (:start . 190) (:id . 72))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 208)\n  (:start . 200) (:id . 74))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 220) (:start . 217)\n  (:id . 76))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 230)\n  (:start . 221) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 242)\n  (:start . 234) (:id . 79))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 249)\n  (:start . 243) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 252) (:start . 250)\n  (:id . 81))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 258)\n  (:start . 253) (:id . 82))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 269)\n  (:start . 259) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1234.2.1) (:span 209 216))\n  ((:id . :x1234.2.3) (:span 176 185)))\n (:ncues ((:id . :x1234.2.2) (:span 187 189)))\n (:hscopes ((:id . :x1234.2.1) (:span 209 269))\n  ((:id . :x1234.2.3) (:span 108 185)))\n (:nscopes ((:id . :x1234.2.2) (:span 187 269)))\n (:identifiers (:sid . :s1234.2) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011488@unknown@formal@none@1@S@To address this issue, we have investigated IL-12 expression in B cells during in vitro transformation with EBV.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "issue") (:form . "issue") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 43)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 102) (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1234.3) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011490@unknown@formal@none@1@S@These B cells expressed p40 and p35 mRNA, and phorbol myristate acetate (PMA) stimulation strongly enhanced p40 and p70 production.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "p35") (:form . "p35") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "myristate") (:form . "myristate") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "acetate") (:form . "acetate") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 89)\n  (:start . 78) (:id . 58))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p70") (:form . "p70") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 130)\n  (:start . 120) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1234.5) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011491@unknown@formal@none@1@S@Furthermore, transfection with LMP1 expression vector into a human B lymphoma cell line, Daudi, led to p40 production with nuclear factor (NF)-kappaB activation.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transfection") (:form . "transfection") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Daudi") (:form . "Daudi") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p40") (:form . "p40") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 137)\n  (:start . 131) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF)-kappaB") (:form . "NF)-kappaB") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 160)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1234.6) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011492@unknown@formal@none@1@S@These results suggest that transformation of primary B cells with EBV induces IL-12 expression potentially through LMP1 expression.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 41) (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "il-12") (:form . "IL-12") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "lmp1") (:form . "LMP1") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 130)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1234.7.1) (:span 95 106))\n  ((:id . :x1234.7.2) (:span 14 21)))\n (:hscopes ((:id . :x1234.7.1) (:span 95 130))\n  ((:id . :x1234.7.2) (:span 14 130)))\n (:identifiers (:sid . :s1234.7) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011493@unknown@formal@none@1@S@Copyright 1998 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1234.8) (:did . :|9837745|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011494@unknown@formal@none@1@S@Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes.@(((:tag . "NNP") (:stem . "Anaphylatoxin") (:form . "Anaphylatoxins")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1235.1) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011495@unknown@formal@none@1@S@The anaphylatoxins C5a and C3a are involved in the regulation of cytokine production.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "anaphylatoxin") (:form . "anaphylatoxins")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1235.2) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011496@unknown@formal@none@1@S@In this study the capability of C5a and C3a to induce transcription factor activation was examined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "capability") (:form . "capability") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 67) (:start . 54) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1235.3) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011497@unknown@formal@none@1@S@C5a and C3a stimulation of human peripheral blood monocytes resulted in nuclear expression of a DNA binding activity with specificity to the kappaB sequence.@(((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 133)\n  (:start . 122) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1235.4) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011498@unknown@formal@none@1@S@The p50 and p65 proteins, constituents of the prototypic nuclear factor kappaB, were identified as components of the DNA-protein complexes by anti-peptide antibodies in gel supershift assays.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "constituent") (:form . "constituents") (:end . 38)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "prototypic") (:form . "prototypic") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 109)\n  (:start . 99) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dna-protein") (:form . "DNA-protein") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "anti-peptide") (:form . "anti-peptide") (:end . 154)\n  (:start . 142) (:id . 65))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 172) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "supershift") (:form . "supershift") (:end . 183)\n  (:start . 173) (:id . 69))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 190)\n  (:start . 184) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1235.5) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011500@unknown@formal@none@1@S@Binding to kappaB sequence was accompanied by an initial decrease and subsequent increase in the cytoplasmic IkappaBalpha levels, as detected by Western blotting using an anti-IkappaBalpha antibody.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 108)\n  (:start . 97) (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha")\n  (:end . 121) (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 152)\n  (:start . 145) (:id . 64))\n ((:tag . "NN") (:stem . "blotting") (:form . "blotting") (:end . 161)\n  (:start . 153) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 167) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "anti-ikappabalpha") (:form . "anti-IkappaBalpha")\n  (:end . 188) (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 197)\n  (:start . 189) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1235.7) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011501@unknown@formal@none@1@S@Pertussis toxin treatment markedly decreased kappaB binding activities induced by both C5a and C3a, whereas cholera toxin displayed no inhibitory effect.@(((:tag . "NN") (:stem . "pertussis") (:form . "Pertussis") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 59)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 70)\n  (:start . 60) (:id . 49))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "cholera") (:form . "cholera") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 131)\n  (:start . 122) (:id . 60))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 145)\n  (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 152)\n  (:start . 146) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1235.8.1) (:span 132 134)))\n (:nscopes ((:id . :x1235.8.1) (:span 132 152)))\n (:identifiers (:sid . :s1235.8) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011502@unknown@formal@none@1@S@Neither of the two toxins affected kappaB binding activity induced by TNFalpha in the same cells.@(((:tag . "DT") (:stem . "neither") (:form . "Neither") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "toxin") (:form . "toxins") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "affect") (:form . "affected") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1235.9.1) (:span 0 7)))\n (:nscopes ((:id . :x1235.9.1) (:span 0 96)))\n (:identifiers (:sid . :s1235.9) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011503@unknown@formal@none@1@S@These results imply a potential role of the anaphylatoxins C5a and C3a in regulating leukocytes gene expression through G protein-coupled transcription factor activation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "imply") (:form . "imply") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "anaphylatoxin") (:form . "anaphylatoxins")\n  (:end . 58) (:start . 44) (:id . 50))\n ((:tag . "NNP") (:stem . "C5a") (:form . "C5a") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "leukocyte") (:form . "leukocytes") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "protein-coupled") (:form . "protein-coupled")\n  (:end . 137) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 151) (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 158)\n  (:start . 152) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 169)\n  (:start . 159) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1235.10.1) (:span 22 31))\n  ((:id . :x1235.10.2) (:span 14 19)))\n (:hscopes ((:id . :x1235.10.1) (:span 22 169))\n  ((:id . :x1235.10.2) (:span 14 169)))\n (:identifiers (:sid . :s1235.10) (:did . :|9838061|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011504@unknown@formal@none@1@S@Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB.@(((:tag . "NN") (:stem . "tpl-2") (:form . "Tpl-2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "trigger") (:form . "triggering") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1236.1) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011505@unknown@formal@none@1@S@The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Tpl-2") (:form . "Tpl-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 101)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1236.2) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011506@unknown@formal@none@1@S@Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tpl-2") (:form . "Tpl-2") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 95)\n  (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 140) (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 155)\n  (:start . 149) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "NN") (:stem . "calcineurin/nfat") (:form . "calcineurin/NFAT")\n  (:end . 186) (:start . 170) (:id . 71))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 195)\n  (:start . 187) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 211)\n  (:start . 203) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 214) (:start . 212)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 227)\n  (:start . 215) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 78))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 240)\n  (:start . 231) (:id . 79))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 250)\n  (:start . 241) (:id . 80))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 255) (:start . 251)\n  (:id . 81))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 264)\n  (:start . 256) (:id . 82))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 270)\n  (:start . 265) (:id . 83))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 279)\n  (:start . 271) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1236.3) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011507@unknown@formal@none@1@S@We, therefore, conclude that signals generated by the convergence of the MAPK and the calcineurin/NFAT pathway are necessary and sufficient for the activation of the IL-2 promoter by Tpl-2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 13)\n  (:start . 4) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "convergence") (:form . "convergence") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "calcineurin/nfat") (:form . "calcineurin/NFAT")\n  (:end . 102) (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 139)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 179)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tpl-2") (:form . "Tpl-2") (:end . 188)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1236.4) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011508@unknown@formal@none@1@S@The activation of both the IL-2 promoter and an NFAT-driven minimal promoter were shown to depend on signals transduced by Raf1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "nfat-driven") (:form . "NFAT-driven") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "minimal") (:form . "minimal") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 97)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "VBN") (:stem . "transduce") (:form . "transduced") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Raf1") (:form . "Raf1") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1236.5) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011510@unknown@formal@none@1@S@Since the activation of NFAT is MAPK-dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "mapk-dependent") (:form . "MAPK-dependent")\n  (:end . 46) (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MAPK") (:form . "MAPK") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tpl-2") (:form . "Tpl-2") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "MEK1") (:form . "MEK1") (:end . 166) (:start . 162)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MEK2") (:form . "MEK2") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1236.7.1) (:span 112 118 131 133))\n  ((:id . :x1236.7.3) (:span 62 71)))\n (:hscopes ((:id . :x1236.7.1) (:span 112 158))\n  ((:id . :x1236.7.3) (:span 62 175)))\n (:identifiers (:sid . :s1236.7) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011511@unknown@formal@none@1@S@In addition, they suggested that the activation of the IL-2 promoter is under the control of not only NFAT but also a second factor whose activation is MEK-dependent.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 124)\n  (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 131)\n  (:start . 125) (:id . 66))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 148)\n  (:start . 138) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mek-dependent") (:form . "MEK-dependent")\n  (:end . 165) (:start . 152) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1236.8.1) (:span 18 27)))\n (:hscopes ((:id . :x1236.8.1) (:span 18 165)))\n (:identifiers (:sid . :s1236.8) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011512@unknown@formal@none@1@S@Experiments in COS-1 and EL-4 cells confirmed both hypotheses and revealed that the second factor activated by Tpl-2 is NF-kappaB.@(((:tag . "NNS") (:stem . "experiment") (:form . "Experiments") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cos-1") (:form . "COS-1") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "el-4") (:form . "EL-4") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hypothesis") (:form . "hypotheses") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tpl-2") (:form . "Tpl-2") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1236.9) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011513@unknown@formal@none@1@S@While the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418, it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2-mediated NFAT activation is under the control of a combination of calcineurin-dependent and independent pathways.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . 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"of") (:end . 299) (:start . 297)\n  (:id . 88))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 301) (:start . 300)\n  (:id . 89))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 313)\n  (:start . 302) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 316) (:start . 314)\n  (:id . 91))\n ((:tag . "JJ") (:stem . "calcineurin-dependent")\n  (:form . "calcineurin-dependent") (:end . 338) (:start . 317) (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 342) (:start . 339)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 354)\n  (:start . 343) (:id . 94))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 363)\n  (:start . 355) (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 364) (:start . 363)\n  (:id . 96)))@@@1@55@((:hcues ((:id . :x1236.10.1) (:span 225 235)))\n (:hscopes ((:id . :x1236.10.1) (:span 225 363)))\n (:identifiers (:sid . :s1236.10) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011514@unknown@formal@none@1@S@Both pathways were fully blocked by Bcl-2 or Bcl-X(L).@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Bcl-X(L)") (:form . "Bcl-X(L)") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1236.11) (:did . :|9840924|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011515@unknown@formal@none@1@S@Activation of human macrophages by mechanical ventilation in vitro.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1237.1) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011516@unknown@formal@none@1@S@Positive-pressure mechanical ventilation supports gas exchange in patients with respiratory failure but is also responsible for significant lung injury.@(((:tag . "JJ") (:stem . "positive-pressure") (:form . "Positive-pressure")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 28)\n  (:start . 18) (:id . 43))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 40)\n  (:start . 29) (:id . 44))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 49)\n  (:start . 41) (:id . 45))\n ((:tag . "NN") (:stem . "gas") (:form . "gas") (:end . 53) (:start . 50)\n  (:id . 46))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 62)\n  (:start . 54) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 74)\n  (:start . 66) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 79) (:start . 75)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "respiratory") (:form . "respiratory") (:end . 91)\n  (:start . 80) (:id . 51))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 99)\n  (:start . 92) (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 103) (:start . 100)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 111) (:start . 107)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 123)\n  (:start . 112) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 127) (:start . 124)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 139)\n  (:start . 128) (:id . 58))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 144) (:start . 140)\n  (:id . 59))\n ((:tag . "NN") (:stem . "injury") (:form . "injury") (:end . 151)\n  (:start . 145) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1237.2) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011517@unknown@formal@none@1@S@In this study, we have developed an in vitro model in which isolated lung cells can be submitted to a prolonged cyclic pressure-stretching strain resembling that of conventional mechanical ventilation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 68)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "submit") (:form . "submitted") (:end . 96)\n  (:start . 87) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 111)\n  (:start . 102) (:id . 63))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 118)\n  (:start . 112) (:id . 64))\n ((:tag . "NN") (:stem . "pressure-stretching")\n  (:form . "pressure-stretching") (:end . 138) (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 145)\n  (:start . 139) (:id . 66))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 156)\n  (:start . 146) (:id . 67))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "conventional") (:form . "conventional") (:end . 177)\n  (:start . 165) (:id . 70))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 188)\n  (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 200)\n  (:start . 189) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1237.3) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011518@unknown@formal@none@1@S@In this model, cells cultured on a Silastic membrane were elongated up to 7% of their initial diameter, corresponding to a 12% increase in cell surface.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "silastic") (:form . "Silastic") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "elongate") (:form . "elongated") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 85)\n  (:start . 80) (:id . 59))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . "NN") (:stem . "diameter") (:form . "diameter") (:end . 102)\n  (:start . 94) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 117)\n  (:start . 104) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 125) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 126) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 135)\n  (:start . 127) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 143) (:start . 139)\n  (:id . 70))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 151)\n  (:start . 144) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1237.4) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011520@unknown@formal@none@1@S@These mediators were measured in supernatants from ventilated alveolar macrophages, monocyte-derived macrophages, and promonocytic THP-1 cells.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mediator") (:form . "mediators") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 45)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "ventilate") (:form . "ventilated") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 82)\n  (:start . 71) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "monocyte-derived") (:form . "monocyte-derived")\n  (:end . 100) (:start . 84) (:id . 53))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 112)\n  (:start . 101) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "promonocytic") (:form . "promonocytic") (:end . 130)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 136)\n  (:start . 131) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 142)\n  (:start . 137) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1237.6) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011521@unknown@formal@none@1@S@Nuclear factor-kappaB was found to be activated in ventilated macrophages.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "factor-kappaB") (:form . "factor-kappaB")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "ventilate") (:form . "ventilated") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1237.7) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011522@unknown@formal@none@1@S@Synergistic proinflammatory effects of mechanical stress and molecules such as bacterial endotoxin were observed, suggesting that mechanical ventilation might be particularly deleterious in preinjured or infected lungs.@(((:tag . "JJ") (:stem . "synergistic") (:form . "Synergistic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "proinflammatory") (:form . "proinflammatory")\n  (:end . 27) (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 35)\n  (:start . 28) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 49)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 56)\n  (:start . 50) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 103) (:start . 99)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 112)\n  (:start . 104) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 124)\n  (:start . 114) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 140)\n  (:start . 130) (:id . 59))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 152)\n  (:start . 141) (:id . 60))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 158)\n  (:start . 153) (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 161) (:start . 159)\n  (:id . 62))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 174)\n  (:start . 162) (:id . 63))\n ((:tag . "JJ") (:stem . "deleterious") (:form . "deleterious") (:end . 186)\n  (:start . 175) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "preinjured") (:form . "preinjured") (:end . 200)\n  (:start . 190) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 203) (:start . 201)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 212)\n  (:start . 204) (:id . 68))\n ((:tag . "NNS") (:stem . "lung") (:form . "lungs") (:end . 218)\n  (:start . 213) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1237.8.1) (:span 153 158))\n  ((:id . :x1237.8.2) (:span 114 124)))\n (:hscopes ((:id . :x1237.8.1) (:span 153 218))\n  ((:id . :x1237.8.2) (:span 114 218)))\n (:identifiers (:sid . :s1237.8) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011523@unknown@formal@none@1@S@Dexamethasone prevented IL-8 and tumor necrosis factor-alpha secretion in ventilated macrophages.@(((:tag . "NNP") (:stem . "Dexamethasone") (:form . "Dexamethasone")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 47)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 60)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "ventilate") (:form . "ventilated") (:end . 84)\n  (:start . 74) (:id . 51))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 96)\n  (:start . 85) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1237.9) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011524@unknown@formal@none@1@S@Mechanical ventilation induced low levels of IL-8 secretion by alveolar type II-like cells.@(((:tag . "JJ") (:stem . "mechanical") (:form . "Mechanical") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 30)\n  (:start . 23) (:id . 44))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ii-like") (:form . "II-like") (:end . 84)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1237.10) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011525@unknown@formal@none@1@S@Other lung cell types such as endothelial cells, bronchial cells, and fibroblasts failed to produce IL-8 in response to a prolonged cyclic pressure-stretching load.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lung") (:form . "lung") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "bronchial") (:form . "bronchial") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "fibroblast") (:form . "fibroblasts") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 88) (:start . 82)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "prolonged") (:form . "prolonged") (:end . 131)\n  (:start . 122) (:id . 64))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . "JJ") (:stem . "pressure-stretching")\n  (:form . "pressure-stretching") (:end . 158) (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "load") (:form . "load") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1237.11.1) (:span 82 88)))\n (:nscopes ((:id . :x1237.11.1) (:span 82 163)))\n (:identifiers (:sid . :s1237.11) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011526@unknown@formal@none@1@S@This model is of particular value for exploring physical stress-induced signaling pathways, as well as for testing the effects of novel ventilatory strategies or adjunctive substances aimed at modulating cell activation induced by mechanical ventilation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "explore") (:form . "exploring") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "stress-induced") (:form . "stress-induced")\n  (:end . 71) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 90)\n  (:start . 82) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "test") (:form . "testing") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "JJ") (:stem . "ventilatory") (:form . "ventilatory") (:end . 147)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "adjunctive") (:form . "adjunctive") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "substance") (:form . "substances") (:end . 183)\n  (:start . 173) (:id . 68))\n ((:tag . "VBN") (:stem . "aim") (:form . "aimed") (:end . 189) (:start . 184)\n  (:id . 69))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "modulate") (:form . "modulating") (:end . 203)\n  (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 208) (:start . 204)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 219)\n  (:start . 209) (:id . 73))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 227)\n  (:start . 220) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 230) (:start . 228)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "mechanical") (:form . "mechanical") (:end . 241)\n  (:start . 231) (:id . 76))\n ((:tag . "NN") (:stem . "ventilation") (:form . "ventilation") (:end . 253)\n  (:start . 242) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1237.12) (:did . :|9843840|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011527@unknown@formal@none@1@S@Stat6 inhibits human interleukin-4 promoter activity in T cells.@(((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interleukin-4") (:form . "interleukin-4")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1238.1) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011528@unknown@formal@none@1@S@The differentiation of naive T-helper (Th) cells into cytokine-secreting effector Th cells requires exposure to multiple signals, including exogenous cytokines.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "T-helper") (:form . "T-helper") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "cytokine-secreting") (:form . "cytokine-secreting")\n  (:end . 72) (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNP") (:stem . "Th") (:form . "Th") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 139)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "exogenous") (:form . "exogenous") (:end . 149)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1238.2) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011530@unknown@formal@none@1@S@In Th2 cells, IL-4 gene expression is tightly controlled at the level of transcription by the coordinated binding of multiple transcription factors to regulatory elements in the proximal promoter region.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "th2") (:form . "Th2") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 34)\n  (:start . 24) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 86) (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "coordinate") (:form . "coordinated") (:end . 105)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 139) (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 161)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 170)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "proximal") (:form . "proximal") (:end . 186)\n  (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 202)\n  (:start . 196) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1238.4) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011531@unknown@formal@none@1@S@Nuclear factor of activated T cell (NFAT) family members play a critical role in regulating IL-4 transcription and interact with up to five sequences (termed P0 through P4) in the IL-4 promoter.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 48)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 91)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 110) (:start . 97) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "p0") (:form . "P0") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 168)\n  (:start . 161) (:id . 71))\n ((:tag . "NN") (:stem . "p4") (:form . "P4") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 75))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 184) (:start . 180)\n  (:id . 76))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 193)\n  (:start . 185) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1238.5) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011532@unknown@formal@none@1@S@The molecular mechanisms by which IL-4 induces expression of the IL-4 gene are not known, although the IL-4-activated transcription factor signal transducer and activator of transcription 6 (Stat6) is required for this effect.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "il-4-activated") (:form . "IL-4-activated")\n  (:end . 117) (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 131) (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 145)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "transducer") (:form . "transducer") (:end . 156)\n  (:start . 146) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 170)\n  (:start . 161) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 187) (:start . 174) (:id . 68))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 191) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "stat6") (:form . "Stat6") (:end . 196)\n  (:start . 191) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 200) (:start . 198)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 209)\n  (:start . 201) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 213) (:start . 210)\n  (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 218) (:start . 214)\n  (:id . 76))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 225)\n  (:start . 219) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1238.6.1) (:span 79 88)))\n (:hscopes ((:id . :x1238.6.1) (:span 0 88)))\n (:identifiers (:sid . :s1238.6) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011533@unknown@formal@none@1@S@We report here that Stat6 interacts with three binding sites in the human IL-4 promoter by electrophoretic mobility shift assays.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 106) (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1238.7) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011534@unknown@formal@none@1@S@These sites overlap the P1, P2, and P4 NFAT elements.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "p1") (:form . "P1") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "P2") (:form . "P2") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "P4") (:form . "P4") (:end . 38) (:start . 36)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 43) (:start . 39)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 52)\n  (:start . 44) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1238.8) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011535@unknown@formal@none@1@S@To investigate the role of Stat6 in regulating IL-4 transcription, we used Stat6-deficient Jurkat T cells with different intact IL-4 promoter constructs in cotransfection assays.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 65) (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "stat6-deficient") (:form . "Stat6-deficient")\n  (:end . 90) (:start . 75) (:id . 55))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 170) (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 177)\n  (:start . 171) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1238.9) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011536@unknown@formal@none@1@S@We show that, whereas a multimerized response element from the germline IgE promoter was highly induced by IL-4 in Stat6-expressing Jurkat cells, the intact human IL-4 promoter was repressed under similar conditions.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 21)\n  (:start . 14) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "multimerized") (:form . "multimerized") (:end . 36)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "germline") (:form . "germline") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "stat6-expressing") (:form . "Stat6-expressing")\n  (:end . 131) (:start . 115) (:id . 62))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 138)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 156)\n  (:start . 150) (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 176)\n  (:start . 168) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 180) (:start . 177)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "repress") (:form . "repressed") (:end . 190)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 204)\n  (:start . 197) (:id . 74))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 215)\n  (:start . 205) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1238.10) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011537@unknown@formal@none@1@S@We conclude that the function of Stat6 is highly dependent on promoter context and that this factor promotes IL-4 gene expression in an indirect manner.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Stat6") (:form . "Stat6") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "indirect") (:form . "indirect") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1238.11) (:did . :|9845517|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011538@unknown@formal@none@1@S@Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "transform") (:form . "transforming") (:end . 31)\n  (:start . 19) (:id . 44))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 38)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "factor-beta") (:form . "factor-beta") (:end . 50)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 59)\n  (:start . 51) (:id . 47))\n ((:tag . "NNS") (:stem . "polymorphism") (:form . "polymorphisms")\n  (:end . 73) (:start . 60) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "allergy") (:form . "allergies") (:end . 86)\n  (:start . 77) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 51))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 97)\n  (:start . 91) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1239.1) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011540@unknown@formal@none@1@S@These cytokines are therefore candidate genes which could contribute to the development of asthma or allergies.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "allergy") (:form . "allergies") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1239.3.1) (:span 52 57)))\n (:hscopes ((:id . :x1239.3.1) (:span 52 110)))\n (:identifiers (:sid . :s1239.3) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011541@unknown@formal@none@1@S@We investigated the hypothesis that polymorphic nucleotides within the IL-10 and TGF-beta gene promoters would link to the expression of allergies and asthma.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "polymorphic") (:form . "polymorphic") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 59)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . "VB") (:stem . "link") (:form . "link") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "allergy") (:form . "allergies") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "asthma") (:form . "asthma") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1239.4.1) (:span 105 110))\n  ((:id . :x1239.4.2) (:span 20 30)))\n (:hscopes ((:id . :x1239.4.1) (:span 105 157))\n  ((:id . :x1239.4.2) (:span 20 157)))\n (:identifiers (:sid . :s1239.4) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011542@unknown@formal@none@1@S@DNA taken from families with an asthmatic proband was examined for base exchanges by single-stranded conformational polymorphism (SSCP).@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "asthmatic") (:form . "asthmatic") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "proband") (:form . "proband") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "exchange") (:form . "exchanges") (:end . 81)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "single-stranded") (:form . "single-stranded")\n  (:end . 100) (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "conformational") (:form . "conformational")\n  (:end . 115) (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 128)\n  (:start . 116) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SSCP") (:form . "SSCP") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1239.5) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011543@unknown@formal@none@1@S@We demonstrated the presence of a polymorphism in the promoter region of the IL-10 gene and four in the TGF-beta gene promoters (3 in TGF-beta1 and 1 in TGF-beta2).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TGF-beta1") (:form . "TGF-beta1") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 70))\n ((:tag . "NN") (:stem . "tgf-beta2") (:form . "TGF-beta2") (:end . 162)\n  (:start . 153) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1239.6) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011544@unknown@formal@none@1@S@The IL-10 gene polymorphism was a C-to-A exchange 571 base pairs upstream from the translation start site and was present between consensus binding sequences for Sp1 and elevated total serum.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "C-to-A") (:form . "C-to-A") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "CD") (:stem . "571") (:form . "571") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "sp1") (:form . "Sp1") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 178)\n  (:start . 170) (:id . 69))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 184)\n  (:start . 179) (:id . 70))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1239.7) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011545@unknown@formal@none@1@S@This polymorphism was associated with elevated total serum IgE in subjects heterozygotic or homozygotic for this base exchange (p < 0.009).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "subject") (:form . "subjects") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "heterozygotic") (:form . "heterozygotic")\n  (:end . 88) (:start . 75) (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "homozygotic") (:form . "homozygotic") (:end . 103)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 126)\n  (:start . 118) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.009") (:form . "0.009") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1239.8) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011546@unknown@formal@none@1@S@The base exchange at -509 (from the transcription initiation site) in the TGF-beta promoter also linked to elevated total IgE (p < 0.01).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "-509") (:form . "-509") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 50))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TGF-beta") (:form . "TGF-beta") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "ige") (:form . "IgE") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1239.9) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011547@unknown@formal@none@1@S@This polymorphism represented a C-to-T base exchange which induced a YY1 consensus sequence and is present in a region of the promoter associated with negative transcription regulation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "represent") (:form . "represented") (:end . 29)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "c-to-t") (:form . "C-to-T") (:end . 38)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "yy1") (:form . "YY1") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 159)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 173) (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 184)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1239.10) (:did . :|9847292|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011548@unknown@formal@none@1@S@The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TNFR)-associated") (:form . "TNFR)-associated")\n  (:end . 76) (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 134)\n  (:start . 125) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 147)\n  (:start . 138) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tnfr") (:form . "TNFR") (:end . 169) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 181)\n  (:start . 170) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1240.1) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011550@unknown@formal@none@1@S@Its cognate ligand (RANKL) plays significant roles in the activation of dendritic cell function and osteoclast differentiation.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cognate") (:form . "cognate") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RANKL") (:form . "RANKL") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "dendritic") (:form . "dendritic") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "osteoclast") (:form . "osteoclast") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 126) (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1240.3) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011551@unknown@formal@none@1@S@We demonstrate here the interaction of RANK with tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 both in vitro and in cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RANK") (:form . "RANK") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "receptor-associated")\n  (:form . "receptor-associated") (:end . 90) (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAFs") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 124) (:start . 123)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 129) (:start . 125)\n  (:id . 68))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 69))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 138)\n  (:start . 133) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 145) (:start . 143)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1240.4) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011552@unknown@formal@none@1@S@Mapping of the structural requirements for TRAF/RANK interaction revealed multiple TRAF binding sites clustered in two distinct domains in the RANK cytoplasmic tail.@(((:tag . "NN") (:stem . "mapping") (:form . "Mapping") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TRAF/RANK") (:form . "TRAF/RANK") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 64)\n  (:start . 53) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 73)\n  (:start . 65) (:id . 50))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 82)\n  (:start . 74) (:id . 51))\n ((:tag . "NN") (:stem . "traf") (:form . "TRAF") (:end . 87) (:start . 83)\n  (:id . 52))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 101) (:start . 96)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "cluster") (:form . "clustered") (:end . 111)\n  (:start . 102) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 118) (:start . 115)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RANK") (:form . "RANK") (:end . 147) (:start . 143)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 159)\n  (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 164) (:start . 160)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1240.5) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011553@unknown@formal@none@1@S@These TRAF binding domains were shown to be functionally important for the RANK-dependent induction of NF-kappaB and c-Jun NH2-terminal kinase activities.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 56)\n  (:start . 44) (:id . 50))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "rank-dependent") (:form . "RANK-dependent")\n  (:end . 89) (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 135)\n  (:start . 123) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 142)\n  (:start . 136) (:id . 61))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 153)\n  (:start . 143) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1240.6) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011554@unknown@formal@none@1@S@Site-directed mutagenesis demonstrated that these TRAF binding sites exhibited selective binding for different TRAF proteins.@(((:tag . "JJ") (:stem . "site-directed") (:form . "Site-directed")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 25)\n  (:start . 14) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 38)\n  (:start . 26) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 54) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 62)\n  (:start . 55) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 78)\n  (:start . 69) (:id . 50))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 88)\n  (:start . 79) (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 110)\n  (:start . 101) (:id . 54))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAF") (:end . 115) (:start . 111)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 124)\n  (:start . 116) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1240.7) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011555@unknown@formal@none@1@S@In particular, TRAF6 interacted with membrane-proximal determinants distinct from those binding TRAFs 1, 2, 3, and 5.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TRAF6") (:form . "TRAF6") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "membrane-proximal") (:form . "membrane-proximal")\n  (:end . 54) (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 67)\n  (:start . 55) (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 51))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 87) (:start . 82)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "NNP") (:stem . "TRAF") (:form . "TRAFs") (:end . 101) (:start . 96)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 103) (:start . 102)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1240.8) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011556@unknown@formal@none@1@S@When this membrane-proximal TRAF6 interaction domain was deleted, RANK-mediated NF-kappaB signaling was completely inhibited while c-Jun NH2-terminal kinase activation was partially inhibited.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "membrane-proximal") (:form . "membrane-proximal")\n  (:end . 27) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "traf6") (:form . "TRAF6") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 52)\n  (:start . 46) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "delete") (:form . "deleted") (:end . 64)\n  (:start . 57) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "rank-mediated") (:form . "RANK-mediated")\n  (:end . 79) (:start . 66) (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 99)\n  (:start . 90) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 54))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 114)\n  (:start . 104) (:id . 55))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 124)\n  (:start . 115) (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 130)\n  (:start . 125) (:id . 57))\n ((:tag . "NN") (:stem . "c-jun") (:form . "c-Jun") (:end . 136)\n  (:start . 131) (:id . 58))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 149)\n  (:start . 137) (:id . 59))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 156)\n  (:start . 150) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 167)\n  (:start . 157) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 171) (:start . 168)\n  (:id . 62))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 181)\n  (:start . 172) (:id . 63))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 191)\n  (:start . 182) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1240.9) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011557@unknown@formal@none@1@S@An NH2-terminal truncation mutant of TRAF6 inhibited RANKL-mediated NF-kappaB activation, but failed to affect constitutive signaling induced by receptor overexpression, revealing a selective role for TRAF6 in ligand-induced activation events.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nh2-terminal") (:form . "NH2-terminal") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "truncation") (:form . "truncation") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TRAF6") (:form . "TRAF6") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "JJ") (:stem . "rankl-mediated") (:form . "RANKL-mediated")\n  (:end . 67) (:start . 53) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 77)\n  (:start . 68) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 88)\n  (:start . 78) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 100)\n  (:start . 94) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 55))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 110)\n  (:start . 104) (:id . 56))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 123)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 133)\n  (:start . 124) (:id . 58))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 141)\n  (:start . 134) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 153)\n  (:start . 145) (:id . 61))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 168) (:start . 154) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "reveal") (:form . "revealing") (:end . 179)\n  (:start . 170) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 191)\n  (:start . 182) (:id . 66))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 196) (:start . 192)\n  (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 200) (:start . 197)\n  (:id . 68))\n ((:tag . "NN") (:stem . "traf6") (:form . "TRAF6") (:end . 206)\n  (:start . 201) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 209) (:start . 207)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "ligand-induced") (:form . "ligand-induced")\n  (:end . 224) (:start . 210) (:id . 71))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 235)\n  (:start . 225) (:id . 72))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 242)\n  (:start . 236) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x1240.10.1) (:span 94 100)))\n (:nscopes ((:id . :x1240.10.1) (:span 94 168)))\n (:identifiers (:sid . :s1240.10) (:did . :|9852070|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011558@unknown@formal@none@1@S@The control of lytic replication of Epstein-Barr virus in B lymphocytes (Review).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Review") (:form . "Review") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1241.1) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011560@unknown@formal@none@1@S@Most viruses cannot compete with the various immune mechanisms and become eliminated in the course of infection.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VB") (:stem . "compete") (:form . "compete") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "VBN") (:stem . "eliminate") (:form . "eliminated") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1241.3.1) (:span 13 19)))\n (:nscopes ((:id . :x1241.3.1) (:span 13 62)))\n (:identifiers (:sid . :s1241.3) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011561@unknown@formal@none@1@S@Therefore, only the time between infection and eradication remains for these viruses to proliferate.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "eradication") (:form . "eradication") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VB") (:stem . "proliferate") (:form . "proliferate") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1241.4) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011562@unknown@formal@none@1@S@A few viruses, like the Herpesviruses or the papillomaviruses, however, have developed a sophisticated strategy for persisting lifelong, usually asymptomatically in the host, hiding from the immune system and producing infectious progeny at the same time.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NNPS") (:stem . "Herpesvirus") (:form . "Herpesviruses")\n  (:end . 37) (:start . 24) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "papillomavirus") (:form . "papillomaviruses")\n  (:end . 61) (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sophisticated") (:form . "sophisticated")\n  (:end . 102) (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "persist") (:form . "persisting") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "lifelong") (:form . "lifelong") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "RB") (:stem . "asymptomatically") (:form . "asymptomatically")\n  (:end . 161) (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "hide") (:form . "hiding") (:end . 181)\n  (:start . 175) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 186) (:start . 182)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 197)\n  (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 204)\n  (:start . 198) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "produce") (:form . "producing") (:end . 218)\n  (:start . 209) (:id . 76))\n ((:tag . "JJ") (:stem . "infectious") (:form . "infectious") (:end . 229)\n  (:start . 219) (:id . 77))\n ((:tag . "NN") (:stem . "progeny") (:form . "progeny") (:end . 237)\n  (:start . 230) (:id . 78))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 240) (:start . 238)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 249) (:start . 245)\n  (:id . 81))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 254) (:start . 250)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1241.5) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011563@unknown@formal@none@1@S@This strategy depends on a separation of latency and the lytic replication, either by time due to differentiation-dependent mechanisms or by spatial separation as the result of different host cell types.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 74)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "differentiation-dependent")\n  (:form . "differentiation-dependent") (:end . 123) (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "spatial") (:form . "spatial") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 159)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 173)\n  (:start . 167) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 186)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 191) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 196) (:start . 192)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1241.6) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011564@unknown@formal@none@1@S@Both are true for the Epstein-Barr virus (EBV).@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1241.7) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011565@unknown@formal@none@1@S@B cells and epithelial cells have a pivotal role in the life cycle of the virus.@(((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pivotal") (:form . "pivotal") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1241.8) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011566@unknown@formal@none@1@S@The former can become latently infected and are thought to be the virus reservoir in vivo, whereas the latter were shown to be permissive for lytic replication.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "former") (:form . "former") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reservoir") (:form . "reservoir") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 98)\n  (:start . 91) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 126) (:start . 124)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 137)\n  (:start . 127) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 147)\n  (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 159)\n  (:start . 148) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1241.9.1) (:span 48 55)))\n (:hscopes ((:id . :x1241.9.1) (:span 44 89)))\n (:identifiers (:sid . :s1241.9) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011567@unknown@formal@none@1@S@However, replication of EBV in vivo is controlled primarily by host immune mechanisms selecting for cells that are not permissive for viral replication as the result of a particular set of transcription factors.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "VBG") (:stem . "select") (:form . "selecting") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "permissive") (:form . "permissive") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 151)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 181)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 202) (:start . 189) (:id . 74))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 210)\n  (:start . 203) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1241.10.1) (:span 115 118)))\n (:nscopes ((:id . :x1241.10.1) (:span 115 151)))\n (:identifiers (:sid . :s1241.10) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011568@unknown@formal@none@1@S@These factors control the activity of the regulatory immediate-early genes and, in addition, lytic and latent cycle regulatory genes negatively interfere with each other and thus link cellular and viral gene regulatory mechanisms.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "immediate-early") (:form . "immediate-early")\n  (:end . 68) (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 132)\n  (:start . 127) (:id . 62))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 143)\n  (:start . 133) (:id . 63))\n ((:tag . "VBP") (:stem . "interfere") (:form . "interfere") (:end . 153)\n  (:start . 144) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 68))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "link") (:form . "link") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 192)\n  (:start . 184) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 202)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 218)\n  (:start . 208) (:id . 75))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 229)\n  (:start . 219) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1241.11) (:did . :|9852211|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011570@unknown@formal@none@1@S@Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type-1") (:form . "type-1") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 49) (:start . 36) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 50) (:start . 49)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 78) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "leader") (:form . "leader") (:end . 85)\n  (:start . 79) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 54))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1242.1) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011571@unknown@formal@none@1@S@Human immunodeficiency virus type-1 (HIV-1) transcription is dependent on the interaction of host-cell transcription factors with cis-regulatory DNA elements within the viral long terminal repeat (LTR).@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 22) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NN") (:stem . "type-1") (:form . "type-1") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "host-cell") (:form . "host-cell") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 116) (:start . 103) (:id . 57))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 124)\n  (:start . 117) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 144) (:start . 130) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 148) (:start . 145)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 157)\n  (:start . 149) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 164)\n  (:start . 158) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 174)\n  (:start . 169) (:id . 65))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 179) (:start . 175)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 188)\n  (:start . 180) (:id . 67))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 195)\n  (:start . 189) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 200) (:start . 197)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 201) (:start . 200)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1242.2) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011572@unknown@formal@none@1@S@Much attention has focused on the series of sequence elements upstream of the transcriptional initiation site in the U3 region of the LTR including the Sp1 and NF-kappaB binding sites.@(((:tag . "JJ") (:stem . "much") (:form . "Much") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "attention") (:form . "attention") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "focus") (:form . "focused") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 93) (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "initiation") (:form . "initiation") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "u3") (:form . "U3") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 169)\n  (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 177)\n  (:start . 170) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 183)\n  (:start . 178) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1242.3) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011573@unknown@formal@none@1@S@Recent studies, however, demonstrate that the transcribed 5'-untranslated leader region (5'-UTR) also contains important transcriptional elements.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "5'-untranslated") (:form . "5'-untranslated")\n  (:end . 73) (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "leader") (:form . "leader") (:end . 80)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 87)\n  (:start . 81) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "5'-UTR") (:form . "5'-UTR") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 136) (:start . 121) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 145)\n  (:start . 137) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1242.4) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011574@unknown@formal@none@1@S@These regulatory elements situated downstream of transcription interact with constitutive and inducible transcription factors, mediate transmission of cellular activation signals, and are important for efficient HIV-1 transcription and replication.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBN") (:stem . "situate") (:form . "situated") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 45)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 62) (:start . 49) (:id . 48))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 71)\n  (:start . 63) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 89)\n  (:start . 77) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 103)\n  (:start . 94) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 117) (:start . 104) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 125)\n  (:start . 118) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 134)\n  (:start . 127) (:id . 57))\n ((:tag . "NN") (:stem . "transmission") (:form . "transmission") (:end . 147)\n  (:start . 135) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 159)\n  (:start . 151) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 170)\n  (:start . 160) (:id . 61))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 178)\n  (:start . 171) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 187) (:start . 184)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 197)\n  (:start . 188) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 201) (:start . 198)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 211)\n  (:start . 202) (:id . 68))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 217)\n  (:start . 212) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 231) (:start . 218) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 71))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 247)\n  (:start . 236) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1242.5) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011575@unknown@formal@none@1@S@The 5'-UTR contains binding sites for the transcription factors AP-1, NF-kappaB, NF-AT, IRF, and Sp1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "5'-utr") (:form . "5'-UTR") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-AT") (:form . "NF-AT") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IRF") (:form . "IRF") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Sp1") (:form . "Sp1") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1242.6) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011576@unknown@formal@none@1@S@Mutations in these binding sites can interfere with the viral response to cell activation signals, decrease LTR transcription, and inhibit viral replication.@(((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "interfere") (:form . "interfere") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "VB") (:stem . "decrease") (:form . "decrease") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 125) (:start . 112) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 156)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1242.7) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011577@unknown@formal@none@1@S@The 5'-UTR also interacts with a specific nucleosome that is rapidly displaced during transcriptional activation of the latent provirus.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "5'-utr") (:form . "5'-UTR") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "nucleosome") (:form . "nucleosome") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "VBN") (:stem . "displace") (:form . "displaced") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . "NN") (:stem . "provirus") (:form . "provirus") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1242.8) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011578@unknown@formal@none@1@S@We propose that the inducible transcription factor binding sites in the 5'-UTR comprise a downstream enhancer domain that can function independent of, or in concert with, the LTR promoter to rapidly increase latent proviral transcription in response to cell activation signals.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "5'-UTR") (:form . "5'-UTR") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "VBP") (:stem . "comprise") (:form . "comprise") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 146)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "concert") (:form . "concert") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 178) (:start . 175)\n  (:id . 71))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 187)\n  (:start . 179) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 190) (:start . 188)\n  (:id . 73))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 198)\n  (:start . 191) (:id . 74))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 207)\n  (:start . 199) (:id . 75))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 214)\n  (:start . 208) (:id . 76))\n ((:tag . "JJ") (:stem . "proviral") (:form . "proviral") (:end . 223)\n  (:start . 215) (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 237) (:start . 224) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 79))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 249)\n  (:start . 241) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 252) (:start . 250)\n  (:id . 81))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 257) (:start . 253)\n  (:id . 82))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 268)\n  (:start . 258) (:id . 83))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 276)\n  (:start . 269) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x1242.9.1) (:span 151 153))\n  ((:id . :x1242.9.2) (:span 3 10)))\n (:hscopes ((:id . :x1242.9.1) (:span 135 169))\n  ((:id . :x1242.9.2) (:span 3 276)))\n (:identifiers (:sid . :s1242.9) (:did . :|9852310|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011580@unknown@formal@none@1@S@Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cloning") (:form . "cloning") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "FKHRL1P2") (:form . "FKHRL1P2") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "developmentally") (:form . "developmentally")\n  (:end . 62) (:start . 47) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "fork") (:form . "fork") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "head") (:form . "head") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 103) (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1243.1) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011581@unknown@formal@none@1@S@Here we report the expression of a fork head domain protein in human T helper cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fork") (:form . "fork") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "head") (:form . "head") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1243.2) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011582@unknown@formal@none@1@S@We cloned and characterized a fork head cDNA from human T helper cell mRNA using differential display RT-PCR.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "clone") (:form . "cloned") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "characterize") (:form . "characterized")\n  (:end . 27) (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fork") (:form . "fork") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "head") (:form . "head") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "helper") (:form . "helper") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 93)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "display") (:form . "display") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "rt-pcr") (:form . "RT-PCR") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1243.3) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011583@unknown@formal@none@1@S@The cDNA contains a 546-nucleotide (nt) open reading frame (ORF) that codes for the carboxyl-terminal 180 amino acids (aa) of the recently identified fkhrl1 gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "546-nucleotide") (:form . "546-nucleotide")\n  (:end . 34) (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nt") (:form . "nt") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORF") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "cod") (:form . "codes") (:end . 75) (:start . 70)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "carboxyl-terminal") (:form . "carboxyl-terminal")\n  (:end . 101) (:start . 84) (:id . 60))\n ((:tag . "CD") (:stem . "180") (:form . "180") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 68))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 138)\n  (:start . 130) (:id . 69))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 149)\n  (:start . 139) (:id . 70))\n ((:tag . "NN") (:stem . "fkhrl1") (:form . "fkhrl1") (:end . 156)\n  (:start . 150) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 161) (:start . 157)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1243.4) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011584@unknown@formal@none@1@S@This ORF does not contain the characteristic DNA-binding domain found in members of the forkhead protein family.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "orf") (:form . "ORF") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "forkhead") (:form . "forkhead") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1243.5.1) (:span 14 17)))\n (:nscopes ((:id . :x1243.5.1) (:span 14 111)))\n (:identifiers (:sid . :s1243.5) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011585@unknown@formal@none@1@S@In-vitro transcription/translation of this cDNA expressed a protein of approximately 20 kDa.@(((:tag . "FW") (:stem . "in-vitro") (:form . "In-vitro") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transcription/translation")\n  (:form . "transcription/translation") (:end . 34) (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 47) (:start . 43)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 57)\n  (:start . 48) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 84) (:start . 71) (:id . 51))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 87) (:start . 85)\n  (:id . 52))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1243.6) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011586@unknown@formal@none@1@S@We have generated antibodies that specifically immunoprecipitated the in-vitro-translated 20-kDa protein.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "immunoprecipitate") (:form . "immunoprecipitated")\n  (:end . 65) (:start . 47) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "in-vitro-translated")\n  (:form . "in-vitro-translated") (:end . 89) (:start . 70) (:id . 50))\n ((:tag . "JJ") (:stem . "20-kda") (:form . "20-kDa") (:end . 96)\n  (:start . 90) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1243.7) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011587@unknown@formal@none@1@S@This antibody also recognizes in human T lymphocytes a 70-kDa protein corresponding in size to that predicted for the fkhrl1 gene product.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "recognize") (:form . "recognizes") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "70-kda") (:form . "70-kDa") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 83)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 91) (:start . 87)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "fkhrl1") (:form . "fkhrl1") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1243.8) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011588@unknown@formal@none@1@S@The mRNA levels for fkhrl1 is elevated in T helper-induced lymphocytes in comparison to PHA-stimulated T lymphocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fkhrl1") (:form . "fkhrl1") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "helper-induced") (:form . "helper-induced")\n  (:end . 58) (:start . 44) (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pha-stimulated") (:form . "PHA-stimulated")\n  (:end . 102) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 116)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1243.9) (:did . :|9852958|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011590@unknown@formal@none@1@S@Activation of the human delta-globin gene promoter in primary adult erythroid cells.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "delta-globin") (:form . "delta-globin") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1244.1) (:did . :|9858241|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011591@unknown@formal@none@1@S@Restoration of the CCAAT box or insertion of an erythroid Kruppel-like factor (EKLF) binding site in the delta promoter activates its expression in several erythroid cell lines.@(((:tag . "NNP") (:stem . "Restoration") (:form . "Restoration") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CCAAT") (:form . "CCAAT") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "kruppel-like") (:form . "Kruppel-like") (:end . 70)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 144)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 155)\n  (:start . 148) (:id . 67))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 165)\n  (:start . 156) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1244.2) (:did . :|9858241|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011592@unknown@formal@none@1@S@We extended these studies using a novel primary human adult erythroid cell (hAEC) system to investigate these effects at the late erythroblast stage.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "extend") (:form . "extended") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "haec") (:form . "hAEC") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 103)\n  (:start . 92) (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "erythroblast") (:form . "erythroblast") (:end . 142)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1244.3) (:did . :|9858241|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011593@unknown@formal@none@1@S@Restoration of the CCAAT box at -70 bp, or insertion of an EKLF binding site at -85 bp or -95 bp in the promoter significantly increased delta globin gene expression in hAEC.@(((:tag . "NNP") (:stem . "Restoration") (:form . "Restoration") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ccaat") (:form . "CCAAT") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "-70") (:form . "-70") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 52)\n  (:start . 43) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 63) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 71)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 76) (:start . 72)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-85") (:form . "-85") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 89) (:start . 87)\n  (:id . 61))\n ((:tag . "CD") (:stem . "-95") (:form . "-95") (:end . 93) (:start . 90)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 96) (:start . 94)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 65))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 112)\n  (:start . 104) (:id . 66))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 126) (:start . 113) (:id . 67))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 136)\n  (:start . 127) (:id . 68))\n ((:tag . "NN") (:stem . "delta") (:form . "delta") (:end . 142)\n  (:start . 137) (:id . 69))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 149)\n  (:start . 143) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "haec") (:form . "hAEC") (:end . 173) (:start . 169)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1244.4) (:did . :|9858241|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011594@unknown@formal@none@1@S@Our results demonstrate that the altered CCAAT box (CCAAC) and the lack of an EKLF binding site in delta-globin contribute to its low level of expression in the hAEC model as well.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "ccaat") (:form . "CCAAT") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CCAAC") (:form . "CCAAC") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "EKLF") (:form . "EKLF") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "delta-globin") (:form . "delta-globin") (:end . 111)\n  (:start . 99) (:id . 62))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 122)\n  (:start . 112) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 153)\n  (:start . 143) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 71))\n ((:tag . "NN") (:stem . "haec") (:form . "hAEC") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 174) (:start . 172)\n  (:id . 74))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 179) (:start . 175)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1244.5.1) (:span 67 71)))\n (:nscopes ((:id . :x1244.5.1) (:span 67 111)))\n (:identifiers (:sid . :s1244.5) (:did . :|9858241|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011595@unknown@formal@none@1@S@Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes.@(((:tag . "NNS") (:stem . "interaction") (:form . "Interactions") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 48) (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 124) (:start . 106) (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 132)\n  (:start . 125) (:id . 57))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 138)\n  (:start . 133) (:id . 58))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 141) (:start . 139)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 147)\n  (:start . 142) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1245.1) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011596@unknown@formal@none@1@S@Class II major histocompatibility (class II) genes are regulated in a B-cell-specific and gamma interferon-inducible fashion.@(((:tag . "NNP") (:stem . "Class") (:form . "Class") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "histocompatibility") (:form . "histocompatibility")\n  (:end . 33) (:start . 15) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "b-cell-specific") (:form . "B-cell-specific")\n  (:end . 85) (:start . 70) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gamma") (:form . "gamma") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "interferon-inducible")\n  (:form . "interferon-inducible") (:end . 116) (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 124)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1245.2) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011597@unknown@formal@none@1@S@The master switch for the expression of these genes is the class II transactivator (CIITA).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "master") (:form . "master") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 82) (:start . 68) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1245.3) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011598@unknown@formal@none@1@S@In this report, we demonstrate that one of the functions of CIITA is to recruit the CREB binding protein (CBP) to class II promoters.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "CIITA") (:form . "CIITA") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "VB") (:stem . "recruit") (:form . "recruit") (:end . 79)\n  (:start . 72) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 109) (:start . 106)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 65))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 119)\n  (:start . 114) (:id . 66))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 122) (:start . 120)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 132)\n  (:start . 123) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1245.4) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011600@unknown@formal@none@1@S@Moreover, a dominant negative form of CBP decreased the activity of class II promoters and levels of class II determinants on the surface of cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "dominant") (:form . "dominant") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "promoter") (:form . "promoters") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "determinant") (:form . "determinants") (:end . 122)\n  (:start . 110) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1245.6) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011601@unknown@formal@none@1@S@Finally, the inhibition of class II gene expression by the glucocorticoid hormone could be attributed to the squelching of CBP by the glucocorticoid receptor.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 73) (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 101)\n  (:start . 91) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "squelching") (:form . "squelching") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "glucocorticoid") (:form . "glucocorticoid")\n  (:end . 148) (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1245.7) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011602@unknown@formal@none@1@S@We conclude that CBP, a histone acetyltransferase, plays an important role in the transcription of class II genes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "CBP") (:form . "CBP") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 49) (:start . 32) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1245.8) (:did . :|9858618|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011603@unknown@formal@none@1@S@Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.@(((:tag . "JJ") (:stem . "nuclear") (:form . "Nuclear") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RE/AP") (:form . "RE/AP") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1246.1) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011604@unknown@formal@none@1@S@IL-2 gene transcription in T cells requires both TCR and costimulatory signals.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "costimulatory") (:form . "costimulatory")\n  (:end . 70) (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1246.2) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011605@unknown@formal@none@1@S@IL-2 promoter activation in Jurkat T cells stimulated with superantigen presented by Raji B cells requires CD28 activation.@(((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "superantigen") (:form . "superantigen") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Raji") (:form . "Raji") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 91) (:start . 90)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1246.3) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011606@unknown@formal@none@1@S@The addition of rCTLA4Ig, which blocks CD28 binding to its ligand, to the cultures decreased IL-2 promoter activation by >80%.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rctla4ig") (:form . "rCTLA4Ig") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 117)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "CD") (:stem . ">80") (:form . ">80") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1246.4) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011607@unknown@formal@none@1@S@Interestingly, CTLA4Ig did not significantly inhibit the activation of either NF of activated T cells (NFAT) or AP-1 reporters.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "CTLA4Ig") (:form . "CTLA4Ig") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "VB") (:stem . "inhibit") (:form . "inhibit") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "NN") (:stem . "nf") (:form . "NF") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "reporter") (:form . "reporters") (:end . 126)\n  (:start . 117) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1246.5) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011608@unknown@formal@none@1@S@Therefore, activation of NFAT and AP-1 is insufficient for IL-2 promoter activation.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1246.6) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011610@unknown@formal@none@1@S@Thus, the requirement for CD28 in IL-2 promoter activation appears to be due to RE/AP and not the NFAT or AP-1 sites.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 21)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cd28") (:form . "CD28") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RE/AP") (:form . "RE/AP") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 110) (:start . 106)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 116)\n  (:start . 111) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1246.8.2) (:span 59 66)))\n (:ncues ((:id . :x1246.8.1) (:span 90 93)))\n (:hscopes ((:id . :x1246.8.2) (:span 6 116)))\n (:nscopes ((:id . :x1246.8.1) (:span 90 116)))\n (:identifiers (:sid . :s1246.8) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011611@unknown@formal@none@1@S@In addition, these data suggest that transcriptional activation of RE/AP is not mediated by NFAT, because activation of a NFAT reporter is not affected by the addition of CTLA4Ig.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 52) (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RE/AP") (:form . "RE/AP") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 135)\n  (:start . 127) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 167)\n  (:start . 159) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "CTLA4Ig") (:form . "CTLA4Ig") (:end . 178)\n  (:start . 171) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1246.9.3) (:span 24 31)))\n (:ncues ((:id . :x1246.9.1) (:span 139 142))\n  ((:id . :x1246.9.2) (:span 76 79)))\n (:hscopes ((:id . :x1246.9.3) (:span 24 178)))\n (:nscopes ((:id . :x1246.9.1) (:span 106 178))\n  ((:id . :x1246.9.2) (:span 37 96)))\n (:identifiers (:sid . :s1246.9) (:did . :|9862666|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011612@unknown@formal@none@1@S@Phenylarsine oxide inhibits ex vivo HIV-1 expression.@(((:tag . "NNP") (:stem . "Phenylarsine") (:form . "Phenylarsine") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "FW") (:stem . "ex") (:form . "ex") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1247.1) (:did . :|9863501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011613@unknown@formal@none@1@S@Phenylarsine oxide (PAO), which is described as an inhibitor of tyrosine phosphatase activity, inhibits H2O2 release from human peripheral blood mononuclear cells (PBMCs) as measured by electrochemistry.@(((:tag . "NNP") (:stem . "Phenylarsine") (:form . "Phenylarsine") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "oxide") (:form . "oxide") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PAO") (:form . "PAO") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 60)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 84)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMCs") (:end . 169)\n  (:start . 164) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 182)\n  (:start . 174) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "electrochemistry") (:form . "electrochemistry")\n  (:end . 202) (:start . 186) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1247.2) (:did . :|9863501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011614@unknown@formal@none@1@S@Since human immunodeficiency virus type 1 (HIV-1) replication is known to be favored under oxidative stress conditions, ex vivo experiments using uninfected PBMCs, primary monocytes or a latently infected promonocytic U1 cell line show that HIV-1 replication and reactivation, monitored by p24 antigen measurement, are inhibited by PAO in a time- and concentration-dependent manner.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 28) (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . 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5011615@unknown@formal@none@1@S@These observations can be linked with the inhibition of NF-kappa B activation when uninfected monocytes are induced by either tumor necrosis factor alpha (TNF-alpha) phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 32) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "uninfected") (:form . "uninfected") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 125)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "alpha") (:form . "alpha") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "NN") (:stem . "phorbol") (:form . "phorbol") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "12-myristate") (:form . "12-myristate") (:end . 186)\n  (:start . 174) (:id . 69))\n ((:tag . "NN") (:stem . "13-acetate") (:form . "13-acetate") (:end . 197)\n  (:start . 187) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PMA") (:form . "PMA") (:end . 202) (:start . 199)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 225) (:start . 207) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 230) (:start . 227)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 231) (:start . 230)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1247.4) (:did . :|9863501|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011616@unknown@formal@none@1@S@Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "stabilize") (:form . "stabilizes") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 36)\n  (:start . 26) (:id . 44))\n ((:tag . "NN") (:stem . "kappab-alpha") (:form . "kappaB-alpha") (:end . 49)\n  (:start . 37) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 58) (:start . 53)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 68)\n  (:start . 59) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1248.1) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011617@unknown@formal@none@1@S@Interleukin-10 (IL-10) protects animals from lethal endotoxemia.@(((:tag . "NNP") (:stem . "Interleukin-10") (:form . "Interleukin-10")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "protect") (:form . "protects") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "endotoxemia") (:form . "endotoxemia") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1248.2) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011618@unknown@formal@none@1@S@This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 74)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 133)\n  (:start . 121) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1248.3) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011620@unknown@formal@none@1@S@NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 56)\n  (:start . 49) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 123)\n  (:start . 116) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 135)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "kappab-alpha") (:form . "kappaB-alpha") (:end . 148)\n  (:start . 136) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 163) (:start . 150) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1248.5) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011621@unknown@formal@none@1@S@We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "resultant") (:form . "resultant") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 95)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 106)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 55))\n ((:tag . "NN") (:stem . "stabilization") (:form . "stabilization")\n  (:end . 123) (:start . 110) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 140) (:start . 127) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1248.6.1) (:span 3 15)))\n (:hscopes ((:id . :x1248.6.1) (:span 3 140)))\n (:identifiers (:sid . :s1248.6) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011622@unknown@formal@none@1@S@The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 84) (:start . 66) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "LPS)-induced") (:form . "LPS)-induced") (:end . 98)\n  (:start . 86) (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 145)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 175) (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 187)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1248.7) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011623@unknown@formal@none@1@S@Monocytes were isolated from human donors.@(((:tag . "NNP") (:stem . "Monocyte") (:form . "Monocytes") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "donor") (:form . "donors") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1248.8) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011624@unknown@formal@none@1@S@Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).@(((:tag . "NNS") (:stem . "cell") (:form . "Cells") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "endotoxin") (:form . "endotoxin") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/mL") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-10") (:form . "IL-10") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ng/ml") (:form . "ng/mL") (:end . 92) (:start . 87)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1248.9.1) (:span 63 70)))\n (:nscopes ((:id . :x1248.9.1) (:span 63 93)))\n (:identifiers (:sid . :s1248.9) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011625@unknown@formal@none@1@S@Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "supernatant") (:form . "supernatants") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 114) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 123)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 129)\n  (:start . 124) (:id . 59))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 135)\n  (:start . 130) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 154) (:start . 141) (:id . 63))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 161)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 172)\n  (:start . 165) (:id . 66))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1248.10) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011626@unknown@formal@none@1@S@We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "CD") (:stem . "798+/-67") (:form . "798+/-67") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "pg/ml") (:form . "pg/mL") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "CD") (:stem . ".001") (:form . ".001") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1248.11) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011627@unknown@formal@none@1@S@IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "attenuate") (:form . "attenuated") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 31) (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 52)\n  (:start . 42) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 47))\n ((:tag . "CD") (:stem . "297+/-54") (:form . "297+/-54") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 63) (:start . 62)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . ".001") (:form . ".001") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1248.12) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011628@unknown@formal@none@1@S@After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 55) (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 95)\n  (:start . 86) (:id . 55))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1248.13) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011630@unknown@formal@none@1@S@IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.@(((:tag . "NNP") (:stem . "IL-10") (:form . "IL-10") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "preserve") (:form . "preserving") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 76) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1248.15.1) (:span 6 13)))\n (:hscopes ((:id . :x1248.15.1) (:span 0 136)))\n (:identifiers (:sid . :s1248.15) (:did . :|9872676|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011631@unknown@formal@none@1@S@Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "fas-ligand") (:form . "fas-ligand") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 42)\n  (:start . 36) (:id . 46))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 61) (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 48))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 72) (:start . 67)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 50))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 89)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 101)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 108)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1249.1) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011632@unknown@formal@none@1@S@T cell receptor engagement activates transcription factors important for cytokine gene regulation.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 68)\n  (:start . 59) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 97)\n  (:start . 87) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1249.2) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011633@unknown@formal@none@1@S@Additionally, this signaling pathway also leads to activation-induced apoptosis in T lymphocytes that is dependent on FasL transcription and expression.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 69) (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 79)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 114)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1249.3) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011634@unknown@formal@none@1@S@Here we demonstrate that nuclear factor kappaB (NF-kappaB), which is involved in the transcriptional regulation of many cytokine genes expressed in activated lymphocytes, also plays a role in T cell activation-induced FasL expression.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 100) (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 111)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 157)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 169)\n  (:start . 158) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 193) (:start . 192)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 198) (:start . 194)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 217) (:start . 199) (:id . 76))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 222) (:start . 218)\n  (:id . 77))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 233)\n  (:start . 223) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1249.4) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011635@unknown@formal@none@1@S@Inhibition of NF-kappaB activity in a T cell hybridoma leads to decreased FasL expression and apoptosis upon T cell receptor stimulation.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hybridoma") (:form . "hybridoma") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "fasl") (:form . "FasL") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 136)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1249.5) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011636@unknown@formal@none@1@S@We identified the NF-kappaB site in the FasL promoter that contributes to such regulation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1249.6) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011637@unknown@formal@none@1@S@Co-expression of p65 (Rel A) with the FasL promoter enhanced its activity, and co-expression of IkappaB dramatically inhibited the inducible promoter activity.@(((:tag . "NNP") (:stem . "Co-expression") (:form . "Co-expression")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "p65") (:form . "p65") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Rel") (:form . "Rel") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 51)\n  (:start . 43) (:id . 52))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "co-expression") (:form . "co-expression")\n  (:end . 92) (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IkappaB") (:form . "IkappaB") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 116)\n  (:start . 104) (:id . 61))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 158)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1249.7) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011638@unknown@formal@none@1@S@In contrast, the transcription factor AP-1 is not required for activation-induced FasL promoter activity.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "ap-1") (:form . "AP-1") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 81) (:start . 63) (:id . 53))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1249.8.1) (:span 46 49)))\n (:nscopes ((:id . :x1249.8.1) (:span 13 104)))\n (:identifiers (:sid . :s1249.8) (:did . :|9873041|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011640@unknown@formal@none@1@S@X-rays-induced secretion of cellular factor(s) that enhance(s) HIV-1 promoter transcription in various non-irradiated transfected cell lines.@(((:tag . "JJ") (:stem . "x-rays-induced") (:form . "X-rays-induced")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 24)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "NNS") (:stem . "factor(s)") (:form . "factor(s)") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "enhance(s)") (:form . "enhance(s)") (:end . 62)\n  (:start . 52) (:id . 48))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 68) (:start . 63)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 91) (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 102)\n  (:start . 95) (:id . 53))\n ((:tag . "JJ") (:stem . "non-irradiated") (:form . "non-irradiated")\n  (:end . 117) (:start . 103) (:id . 54))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 129)\n  (:start . 118) (:id . 55))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 134) (:start . 130)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 140)\n  (:start . 135) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1250.1) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011641@unknown@formal@none@1@S@Various cellular stress agents like ionizing radiation exposure could activate human immunodeficiency virus type 1 (HIV- 1) replication or reporter gene expression.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 30)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 69) (:start . 64)\n  (:id . 50))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 101) (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 107)\n  (:start . 102) (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 114) (:start . 113)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hiv-") (:form . "HIV-") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 122) (:start . 121)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 135)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1250.2) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011642@unknown@formal@none@1@S@In addition, extracellular factor(s) released by X-ray-treated human colonic carcinoma cell line (HT29) might activate the long terminal repeat (LTR) of HIV-1 in non-irradiated HT29 cells.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "factor(s)") (:form . "factor(s)") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "x-ray-treated") (:form . "X-ray-treated")\n  (:end . 62) (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "colonic") (:form . "colonic") (:end . 76)\n  (:start . 69) (:id . 51))\n ((:tag . "NN") (:stem . "carcinoma") (:form . "carcinoma") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 96) (:start . 92)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ht29") (:form . "HT29") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 143)\n  (:start . 137) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "non-irradiated") (:form . "non-irradiated")\n  (:end . 176) (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "ht29") (:form . "HT29") (:end . 181) (:start . 177)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1250.3.1) (:span 104 109)))\n (:hscopes ((:id . :x1250.3.1) (:span 104 187)))\n (:identifiers (:sid . :s1250.3) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011643@unknown@formal@none@1@S@In the present report we show that in various transiently or stably transfected cell lines, X-ray irradiation up-regulates HIV-1 LTR transcription through the kappaB regulatory elements.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "x-ray") (:form . "X-ray") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 109)\n  (:start . 98) (:id . 59))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "up-regulates") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 146) (:start . 133) (:id . 63))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 176)\n  (:start . 166) (:id . 67))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 185)\n  (:start . 177) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1250.4) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011644@unknown@formal@none@1@S@A factor(s), which is processed by and acts upon a variety of cell types, was detected by addition to non-irradiated cells of either X-ray-treated cells or a conditioned medium taken from irradiated cultures.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "factor(s)") (:form . "factor(s)") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "process") (:form . "processed") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 86)\n  (:start . 78) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 98)\n  (:start . 90) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "non-irradiated") (:form . "non-irradiated")\n  (:end . 116) (:start . 102) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 132)\n  (:start . 126) (:id . 66))\n ((:tag . "JJ") (:stem . "x-ray-treated") (:form . "X-ray-treated")\n  (:end . 146) (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "conditioned") (:form . "conditioned") (:end . 169)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 176)\n  (:start . 170) (:id . 72))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 182)\n  (:start . 177) (:id . 73))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "irradiated") (:form . "irradiated") (:end . 198)\n  (:start . 188) (:id . 75))\n ((:tag . "NNS") (:stem . "culture") (:form . "cultures") (:end . 207)\n  (:start . 199) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1250.5) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011645@unknown@formal@none@1@S@The magnitude of responsiveness is cell type dependent.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "responsiveness") (:form . "responsiveness")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1250.6) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011646@unknown@formal@none@1@S@In addition, X-ray activation of HIV-1 LTR in transiently or stably transfected cell lines is inhibited by a potent antioxidant drug, pyrrolidine dithiocarbamate and by another drug, known for its role in the trapping of growth factors, suramin.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "x-ray") (:form . "X-ray") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "RB") (:stem . "transiently") (:form . "transiently") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "JJ") (:stem . "antioxidant") (:form . "antioxidant") (:end . 127)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pyrrolidine") (:form . "pyrrolidine") (:end . 145)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "dithiocarbamate") (:form . "dithiocarbamate")\n  (:end . 161) (:start . 146) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 176)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "drug") (:form . "drug") (:end . 181) (:start . 177)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 188)\n  (:start . 183) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 192) (:start . 189)\n  (:id . 73))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 196) (:start . 193)\n  (:id . 74))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 201) (:start . 197)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "trapping") (:form . "trapping") (:end . 217)\n  (:start . 209) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 79))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 227)\n  (:start . 221) (:id . 80))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 235)\n  (:start . 228) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 236) (:start . 235)\n  (:id . 82))\n ((:tag . "NN") (:stem . "suramin") (:form . "suramin") (:end . 244)\n  (:start . 237) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1250.7) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011647@unknown@formal@none@1@S@The importance of these observations in the pathophysiology of patients with AIDS-related cancers treated by radiotherapy remains to be established.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathophysiology") (:form . "pathophysiology")\n  (:end . 59) (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "aids-related") (:form . "AIDS-related") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "cancer") (:form . "cancers") (:end . 97)\n  (:start . 90) (:id . 54))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 105)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "NN") (:stem . "radiotherapy") (:form . "radiotherapy") (:end . 121)\n  (:start . 109) (:id . 57))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 129)\n  (:start . 122) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 147)\n  (:start . 136) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1250.8) (:did . :|9874515|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011648@unknown@formal@none@1@S@Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein.@(((:tag . "NNP") (:stem . "Reactivation") (:form . "Reactivation") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Kaposi") (:form . "Kaposi") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "sarcoma-associated") (:form . "sarcoma-associated")\n  (:end . 43) (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "herpesvirus") (:form . "herpesvirus") (:end . 55)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 65)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 49))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORF") (:end . 103) (:start . 100)\n  (:id . 55))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 121) (:start . 107) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "r") (:form . "R") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1251.1) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011650@unknown@formal@none@1@S@The primary reservoir of infection consists of latently infected B lymphocytes and possibly other mononuclear cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "reservoir") (:form . "reservoir") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 109)\n  (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1251.3.1) (:span 83 91)))\n (:hscopes ((:id . :x1251.3.1) (:span 83 115)))\n (:identifiers (:sid . :s1251.3) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011651@unknown@formal@none@1@S@Viral reactivation from latency and spread from this lymphoid reservoir is presumably required for development of nonlymphoid tumors like KS.@(((:tag . "JJ") (:stem . "viral") (:form . "Viral") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reactivation") (:form . "reactivation") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "spread") (:form . "spread") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "lymphoid") (:form . "lymphoid") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "reservoir") (:form . "reservoir") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "nonlymphoid") (:form . "nonlymphoid") (:end . 125)\n  (:start . 114) (:id . 58))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ks") (:form . "KS") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1251.4.1) (:span 75 85)))\n (:hscopes ((:id . :x1251.4.1) (:span 0 140)))\n (:identifiers (:sid . :s1251.4) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011652@unknown@formal@none@1@S@Here we show that deregulated expression of a single viral gene, ORF 50, which encodes a transactivator able to selectively upregulate delayed-early viral genes, suffices to disrupt latency and induce the lytic gene cascade in latently infected B cells.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "deregulate") (:form . "deregulated") (:end . 29)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORF") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transactivator") (:form . "transactivator")\n  (:end . 103) (:start . 89) (:id . 60))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 123)\n  (:start . 112) (:id . 63))\n ((:tag . "VB") (:stem . "upregulate") (:form . "upregulate") (:end . 134)\n  (:start . 124) (:id . 64))\n ((:tag . "JJ") (:stem . "delayed-early") (:form . "delayed-early")\n  (:end . 148) (:start . 135) (:id . 65))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 160)\n  (:start . 155) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "suffice") (:form . "suffices") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 181)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 189)\n  (:start . 182) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 73))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 200)\n  (:start . 194) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "lytic") (:form . "lytic") (:end . 210)\n  (:start . 205) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 215) (:start . 211)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 223)\n  (:start . 216) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 79))\n ((:tag . "RB") (:stem . "latently") (:form . "latently") (:end . 235)\n  (:start . 227) (:id . 80))\n ((:tag . "JJ") (:stem . "infected") (:form . "infected") (:end . 244)\n  (:start . 236) (:id . 81))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 246) (:start . 245)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 252)\n  (:start . 247) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1251.5) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011653@unknown@formal@none@1@S@The identification of this gene opens the way to studies of the physiologic mechanisms controlling reactvation of KSHV from latency.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "open") (:form . "opens") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "physiologic") (:form . "physiologic") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "VBG") (:stem . "control") (:form . "controlling") (:end . 98)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "reactvation") (:form . "reactvation") (:end . 110)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "KSHV") (:form . "KSHV") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "latency") (:form . "latency") (:end . 131)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1251.6) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011654@unknown@formal@none@1@S@Copyright 1998 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1251.7) (:did . :|9878608|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011655@unknown@formal@none@1@S@Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP.@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 31) (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 45) (:start . 32) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 61)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 67) (:start . 62)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 76)\n  (:start . 68) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 85)\n  (:start . 79) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 95)\n  (:start . 89) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 108) (:start . 105)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 114)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 126)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RBP") (:form . "RBP") (:end . 135) (:start . 132)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1252.1) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011656@unknown@formal@none@1@S@Epstein-Barr virus (EBV) infects B cells, resulting in the outgrowth of immortalised lymphoblastoid cell lines (LCLs).@(((:tag . "JJ") (:stem . "epstein-barr") (:form . "Epstein-Barr") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "infect") (:form . "infects") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "outgrowth") (:form . "outgrowth") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "immortalised") (:form . "immortalised") (:end . 84)\n  (:start . 72) (:id . 56))\n ((:tag . "JJ") (:stem . "lymphoblastoid") (:form . "lymphoblastoid")\n  (:end . 99) (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCLs") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1252.2) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011657@unknown@formal@none@1@S@Here, we demonstrate through the use of intracellular staining that interleukin-1beta (IL-1beta) is expressed in LCLs and investigate the influence of the individual latent proteins on the expression of IL-1beta.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 20)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 53) (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "interleukin-1beta") (:form . "interleukin-1beta")\n  (:end . 85) (:start . 68) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "lcl") (:form . "LCLs") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 133)\n  (:start . 122) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 165)\n  (:start . 155) (:id . 67))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 172)\n  (:start . 166) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 181)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 199)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 211)\n  (:start . 203) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1252.3) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011658@unknown@formal@none@1@S@Using RT-PCR, IL-1beta was shown to be up-regulated in EBV-transformed LCLs as well as in group III Burkitt's lymphoma (BL) cell lines, compared with group I BL cell lines.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RT-PCR") (:form . "RT-PCR") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 51)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 70) (:start . 55) (:id . 52))\n ((:tag . "NNP") (:stem . "LCL") (:form . "LCLs") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Burkitt") (:form . "Burkitt") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lymphoma") (:form . "lymphoma") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "BL") (:form . "BL") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 134)\n  (:start . 129) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 144)\n  (:start . 136) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 149) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 155)\n  (:start . 150) (:id . 71))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 157) (:start . 156)\n  (:id . 72))\n ((:tag . "NN") (:stem . "bl") (:form . "BL") (:end . 160) (:start . 158)\n  (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 171)\n  (:start . 166) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1252.4) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011660@unknown@formal@none@1@S@Electrophoretic mobility shift assays (EMSAs) demonstrated that the -300 region of the IL-1beta promoter, which contains a nuclear factor-kappaB (NF-kappaB) binding site, contained a functional RBP binding site.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "-300") (:form . "-300") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 144) (:start . 131) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 180)\n  (:start . 171) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 182) (:start . 181)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 193)\n  (:start . 183) (:id . 72))\n ((:tag . "NNP") (:stem . "RBP") (:form . "RBP") (:end . 197) (:start . 194)\n  (:id . 73))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 205)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 210) (:start . 206)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1252.6) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011661@unknown@formal@none@1@S@Binding of RBP to this site could be inhibited by addition of EBV nuclear proteins 3 and 6, suggesting that these proteins displace RBP from its recognition sequence, removing transcriptional repression and allowing gene transcription to occur.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "RBP") (:form . "RBP") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 102)\n  (:start . 92) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "VBP") (:stem . "displace") (:form . "displace") (:end . 131)\n  (:start . 123) (:id . 65))\n ((:tag . "NNP") (:stem . "RBP") (:form . "RBP") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 156)\n  (:start . 145) (:id . 69))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 165)\n  (:start . 157) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "remove") (:form . "removing") (:end . 175)\n  (:start . 167) (:id . 72))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 191) (:start . 176) (:id . 73))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 202)\n  (:start . 192) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 215)\n  (:start . 207) (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 220) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 234) (:start . 221) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 237) (:start . 235)\n  (:id . 79))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 243)\n  (:start . 238) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1252.7.1) (:span 92 102)))\n (:hscopes ((:id . :x1252.7.1) (:span 92 243)))\n (:identifiers (:sid . :s1252.7) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011662@unknown@formal@none@1@S@In group I BL cells, containing low levels of NF-kappaB, only RBP binding was observed in EMSAs, whereas NF-kappaB binding could be demonstrated in EBV-transformed B cell lines containing high levels of activated NF-kappaB.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "BL") (:form . "BL") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 31)\n  (:start . 21) (:id . 48))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 55)\n  (:start . 46) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RBP") (:form . "RBP") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 73)\n  (:start . 66) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 86)\n  (:start . 78) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "EMSA") (:form . "EMSAs") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 104)\n  (:start . 97) (:id . 62))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 114)\n  (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 64))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 144)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "ebv-transformed") (:form . "EBV-transformed")\n  (:end . 163) (:start . 148) (:id . 69))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 170) (:start . 166)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 187)\n  (:start . 177) (:id . 73))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 199)\n  (:start . 193) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 212)\n  (:start . 203) (:id . 77))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 222)\n  (:start . 213) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1252.8) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011663@unknown@formal@none@1@S@In addition, the expression of latent membrane protein-1 led to activation of NF-kappaB that was capable of binding the IL-1beta promoter.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latent") (:form . "latent") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 128)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1252.9) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011664@unknown@formal@none@1@S@The study demonstrates that EBV can up-regulate IL-1beta expression, possibly by using RBP, NF-kappaB, or both.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "EBV") (:form . "EBV") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VB") (:stem . "up-regulate") (:form . "up-regulate") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RBP") (:form . "RBP") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1252.10.1) (:span 103 105))\n  ((:id . :x1252.10.2) (:span 69 77)))\n (:hscopes ((:id . :x1252.10.1) (:span 87 110))\n  ((:id . :x1252.10.2) (:span 69 110)))\n (:identifiers (:sid . :s1252.10) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011665@unknown@formal@none@1@S@Copyright 1998 Academic Press.@(((:tag . "NNP") (:stem . "Copyright") (:form . "Copyright") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Academic") (:form . "Academic") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Press") (:form . "Press") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1252.11) (:did . :|9878621|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011666@unknown@formal@none@1@S@Characterization of the human elk-1 promoter.@(((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1253.1) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011667@unknown@formal@none@1@S@Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes.@(((:tag . "JJ") (:stem . "potential") (:form . "Potential") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "intronic") (:form . "intronic") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1253.2.1) (:span 0 9)))\n (:hscopes ((:id . :x1253.2.1) (:span 0 87)))\n (:identifiers (:sid . :s1253.2) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011668@unknown@formal@none@1@S@To characterize the human elk-1 promoter, we mapped the transcriptional start site and isolated elk-1-specific genomic phage clones that contained extensive upstream and downstream sequences.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "characterize") (:form . "characterize") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "map") (:form . "mapped") (:end . 51) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 71) (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "JJ") (:stem . "elk-1-specific") (:form . "elk-1-specific")\n  (:end . 110) (:start . 96) (:id . 57))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "phage") (:form . "phage") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 146)\n  (:start . 137) (:id . 62))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 156)\n  (:start . 147) (:id . 63))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 165)\n  (:start . 157) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 180)\n  (:start . 170) (:id . 66))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 190)\n  (:start . 181) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1253.3) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011670@unknown@formal@none@1@S@Functional analyses of DNA fragments containing the TATA element and the identification of a DNase I-hypersensitive chromatin site (HS 1) in close proximity to the TATA box suggest that the identified TATA motif is important for elk-1 transcription in vivo.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 87) (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "DNase") (:form . "DNase") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "i-hypersensitive") (:form . "I-hypersensitive")\n  (:end . 115) (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 125)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 130) (:start . 126)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "proximity") (:form . "proximity") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 168) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 200)\n  (:start . 190) (:id . 74))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 211)\n  (:start . 206) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 224)\n  (:start . 215) (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 228) (:start . 225)\n  (:id . 79))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 234)\n  (:start . 229) (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 248) (:start . 235) (:id . 81))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 251) (:start . 249)\n  (:id . 82))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 256) (:start . 252)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1253.5.1) (:span 173 180)))\n (:hscopes ((:id . :x1253.5.1) (:span 173 256)))\n (:identifiers (:sid . :s1253.5) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011671@unknown@formal@none@1@S@Sequences upstream and downstream from the TATA box were found to contribute to elk-1 promoter activity.@(((:tag . "NNP") (:stem . "Sequence") (:form . "Sequences") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TATA") (:form . "TATA") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "box") (:form . "box") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 76)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1253.6) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011672@unknown@formal@none@1@S@A second hypersensitive site (HS 2) was identified within the first intron in pre-monocytic cells, which express Elk-1 only when differentiating to monocytes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "hypersensitive") (:form . "hypersensitive")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 50)\n  (:start . 40) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "pre-monocytic") (:form . "pre-monocytic")\n  (:end . 91) (:start . 78) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 60))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "elk-1") (:form . "Elk-1") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 128) (:start . 124)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 144) (:start . 129) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1253.7) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011673@unknown@formal@none@1@S@In a variety of other cell types, which display a constitutive Elk-1 expression, HS 2 did not exist, suggesting that inducibility of elk-1 expression is associated with the presence of HS 2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 12)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "display") (:form . "display") (:end . 47)\n  (:start . 40) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 62)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "elk-1") (:form . "Elk-1") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 99) (:start . 94)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 111)\n  (:start . 101) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "inducibility") (:form . "inducibility") (:end . 129)\n  (:start . 117) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 138)\n  (:start . 133) (:id . 67))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 149)\n  (:start . 139) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 152) (:start . 150)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 163)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 168) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 181)\n  (:start . 173) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 187) (:start . 185)\n  (:id . 75))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 189) (:start . 188)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1253.8.1) (:span 101 111)))\n (:ncues ((:id . :x1253.8.2) (:span 90 93)))\n (:hscopes ((:id . :x1253.8.1) (:span 101 189)))\n (:nscopes ((:id . :x1253.8.2) (:span 90 99)))\n (:identifiers (:sid . :s1253.8) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011674@unknown@formal@none@1@S@Egr-1 and the serum response factor were found to interact specifically with the intronic sequence at +265 and +448, respectively.@(((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intronic") (:form . "intronic") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "CD") (:stem . "+265") (:form . "+265") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "CD") (:stem . "+448") (:form . "+448") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 129)\n  (:start . 117) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1253.9) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011675@unknown@formal@none@1@S@Because Egr-1 mRNA and protein levels were observed to increase significantly before induction of elk-1 expression, we propose that Egr-1 is important for the regulation of elk-1 transcription in differentiating monocytes.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 114)\n  (:start . 104) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 169)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "elk-1") (:form . "elk-1") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 192) (:start . 179) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "differentiate") (:form . "differentiating")\n  (:end . 211) (:start . 196) (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 221)\n  (:start . 212) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1253.10.1) (:span 119 126)))\n (:hscopes ((:id . :x1253.10.1) (:span 119 221)))\n (:identifiers (:sid . :s1253.10) (:did . :|9880555|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011676@unknown@formal@none@1@S@Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tax") (:form . "tax") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "abrogate") (:form . "abrogates") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "interleukin-2") (:form . "interleukin-2")\n  (:end . 70) (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1254.1) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011677@unknown@formal@none@1@S@Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "etiologic") (:form . "etiologic") (:end . 60)\n  (:start . 51) (:id . 53))\n ((:tag . "NN") (:stem . "agent") (:form . "agent") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t-cell") (:form . "T-cell") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "NN") (:stem . "leukemia") (:form . "leukemia") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1254.2) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011678@unknown@formal@none@1@S@Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 48)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 67)\n  (:start . 56) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 82)\n  (:start . 75) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "transform") (:form . "transforms") (:end . 103)\n  (:start . 93) (:id . 62))\n ((:tag . "JJ") (:stem . "healthy") (:form . "healthy") (:end . 111)\n  (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 113) (:start . 112)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 128)\n  (:start . 123) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 140)\n  (:start . 133) (:id . 69))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 147)\n  (:start . 141) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 161)\n  (:start . 151) (:id . 72))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 169)\n  (:start . 162) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1254.3.1) (:span 27 34)))\n (:hscopes ((:id . :x1254.3.1) (:span 0 82)))\n (:identifiers (:sid . :s1254.3) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011680@unknown@formal@none@1@S@Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent.@(((:tag . "JJ") (:stem . "stable") (:form . "Stable") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "transform") (:form . "transformed") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1254.5) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011681@unknown@formal@none@1@S@Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter.@(((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 46)\n  (:start . 37) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "JJ") (:stem . "amp-responsive") (:form . "AMP-responsive")\n  (:end . 76) (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "element-like") (:form . "element-like") (:end . 89)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 98)\n  (:start . 90) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 112)\n  (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 121)\n  (:start . 113) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1254.6) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011682@unknown@formal@none@1@S@The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBG") (:stem . "segregate") (:form . "segregating") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "il-2-independent") (:form . "IL-2-independent")\n  (:end . 129) (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 136)\n  (:start . 130) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ctll-2") (:form . "CTLL-2") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 158)\n  (:start . 153) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "unnecessary") (:form . "unnecessary") (:end . 190)\n  (:start . 179) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1254.7.1) (:span 58 67)))\n (:hscopes ((:id . :x1254.7.1) (:span 58 190)))\n (:identifiers (:sid . :s1254.7) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011683@unknown@formal@none@1@S@However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "transformation-related")\n  (:form . "transformation-related") (:end . 72) (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 52))\n ((:tag . "NN") (:stem . "colony") (:form . "colony") (:end . 89)\n  (:start . 83) (:id . 53))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 99)\n  (:start . 90) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "soft") (:form . "soft") (:end . 107) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "agar") (:form . "agar") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CTLL-2/Tax") (:form . "CTLL-2/Tax") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1254.8) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011684@unknown@formal@none@1@S@Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 101) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 111)\n  (:start . 104) (:id . 63))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "il-2-independent") (:form . "IL-2-independent")\n  (:end . 136) (:start . 120) (:id . 66))\n ((:tag . "NNP") (:stem . "T-cell") (:form . "T-cell") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 158) (:start . 144) (:id . 68))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 176)\n  (:start . 170) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 189)\n  (:start . 181) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 192) (:start . 190)\n  (:id . 75))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 196) (:start . 193)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "well-known") (:form . "well-known") (:end . 207)\n  (:start . 197) (:id . 77))\n ((:tag . "JJ") (:stem . "il-2-dependent") (:form . "IL-2-dependent")\n  (:end . 222) (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 227) (:start . 223)\n  (:id . 79))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 242) (:start . 228) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1254.9.1) (:span 79 86)))\n (:hscopes ((:id . :x1254.9.1) (:span 79 242)))\n (:identifiers (:sid . :s1254.9) (:did . :|9882331|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011685@unknown@formal@none@1@S@Mildly oxidized low-density lipoproteins decrease early production of interleukin 2 and nuclear factor kappaB binding to DNA in activated T-lymphocytes.@(((:tag . "RB") (:stem . "mildly") (:form . "Mildly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "oxidize") (:form . "oxidized") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "low-density") (:form . "low-density") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 40)\n  (:start . 28) (:id . 45))\n ((:tag . "VBP") (:stem . "decrease") (:form . "decrease") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 55) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 81)\n  (:start . 70) (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 83) (:start . 82)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 102)\n  (:start . 96) (:id . 54))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 109)\n  (:start . 103) (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 137)\n  (:start . 128) (:id . 60))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 151) (:start . 138) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1255.1) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011686@unknown@formal@none@1@S@Activated T-lymphocytes are found early in atherosclerosis lesions, but little is known about their role.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 23) (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 58) (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 99)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1255.2) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011687@unknown@formal@none@1@S@Oxidized low-density lipoproteins (oxLDLs) are considered to be involved in the pathogenesis of the lesions, and we have previously demonstrated that oxLDLs inhibit not only interleukin (IL)-2-receptor expression on the surface of in vitro-activated T-lymphocytes but also their proliferation.@(((:tag . "VBN") (:stem . "oxidize") (:form . "Oxidized") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "low-density") (:form . "low-density") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "oxldl") (:form . "oxLDLs") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 92)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "lesion") (:form . "lesions") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 144)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "oxldl") (:form . "oxLDLs") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "VBP") (:stem . "inhibit") (:form . "inhibit") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 173) (:start . 169)\n  (:id . 69))\n ((:tag . "NN") (:stem . "interleukin") (:form . "interleukin") (:end . 185)\n  (:start . 174) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IL)-2-receptor") (:form . "IL)-2-receptor")\n  (:end . 201) (:start . 187) (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 212)\n  (:start . 202) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 215) (:start . 213)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 75))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 227)\n  (:start . 220) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "vitro-activated") (:form . "vitro-activated")\n  (:end . 249) (:start . 234) (:id . 79))\n ((:tag . "NNS") (:stem . "t-lymphocyte") (:form . "T-lymphocytes")\n  (:end . 263) (:start . 250) (:id . 80))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 267) (:start . 264)\n  (:id . 81))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 272) (:start . 268)\n  (:id . 82))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 278)\n  (:start . 273) (:id . 83))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 292) (:start . 279) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s1255.3) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011688@unknown@formal@none@1@S@We have now investigated the effect of oxLDLs on blast differentiation, on IL-2 synthesis and on the activation of the nuclear factor kappaB (NF-kappaB) system in activated lymphocytes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "oxldl") (:form . "oxLDLs") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "blast") (:form . "blast") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 70) (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 151)\n  (:start . 142) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 159)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 184)\n  (:start . 173) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1255.4) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011690@unknown@formal@none@1@S@The inhibition of IL-2 production was observed in the CD3(+) T-lymphocyte cytoplasm as early as 4 h after activation by PMA+ionomycin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "CD3(+)") (:form . "CD3(+)") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "early") (:form . "early") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PMA+ionomycin") (:form . "PMA+ionomycin")\n  (:end . 133) (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1255.6) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011691@unknown@formal@none@1@S@The study of NF-kappaB showed that oxLDLs led to a decrease of activation-induced p65/p50 NF-kappaB heterodimer binding to DNA, whereas the presence of the constitutive nuclear form of p50 dimer was unchanged.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "oxldl") (:form . "oxLDLs") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "activation-induced") (:form . "activation-induced")\n  (:end . 81) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "p65/p50") (:form . "p65/p50") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 111)\n  (:start . 100) (:id . 57))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 168)\n  (:start . 156) (:id . 67))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 176)\n  (:start . 169) (:id . 68))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "dimer") (:form . "dimer") (:end . 194)\n  (:start . 189) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 208)\n  (:start . 199) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1255.7) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011692@unknown@formal@none@1@S@This was correlated with an unchanged level of the active form of the cytosolic inhibitor protein IkappaB-alpha.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unchanged") (:form . "unchanged") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "cytosolic") (:form . "cytosolic") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "IkappaB-alpha") (:form . "IkappaB-alpha")\n  (:end . 111) (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1255.8) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011693@unknown@formal@none@1@S@Taken together, these observations suggest that the immunosuppressive effect of oxLDLs might operate via a dysregulation of the T-lymphocyte activation mechanisms.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immunosuppressive") (:form . "immunosuppressive")\n  (:end . 69) (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "oxldl") (:form . "oxLDLs") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "operate") (:form . "operate") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 120) (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "T-lymphocyte") (:form . "T-lymphocyte")\n  (:end . 140) (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 162)\n  (:start . 152) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1255.9.1) (:span 87 92))\n  ((:id . :x1255.9.2) (:span 35 42)))\n (:hscopes ((:id . :x1255.9.1) (:span 87 162))\n  ((:id . :x1255.9.2) (:span 35 162)))\n (:identifiers (:sid . :s1255.9) (:did . :|9882624|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011694@unknown@formal@none@1@S@Binding of HMG-I(Y) elicits structural changes in a silencer of the human beta-globin gene.@(((:tag . "NN") (:stem . "binding") (:form . "Binding") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "elicit") (:form . "elicits") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1256.1) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011695@unknown@formal@none@1@S@Proteins involved in repression of the human beta-globin gene may be useful in the treatment of sickle cell anemia, in conjunction with therapy to reactivate fetal globin genes.@(((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sickle") (:form . "sickle") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "anemia") (:form . "anemia") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 130)\n  (:start . 119) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "therapy") (:form . "therapy") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "VB") (:stem . "reactivate") (:form . "reactivate") (:end . 157)\n  (:start . 147) (:id . 67))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1256.2.1) (:span 62 65)))\n (:hscopes ((:id . :x1256.2.1) (:span 62 176)))\n (:identifiers (:sid . :s1256.2) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011696@unknown@formal@none@1@S@If there is a reciprocal elevation of gamma-globin expression upon repression, this approach could be useful in additional hemoglobinopathies.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "reciprocal") (:form . "reciprocal") (:end . 24)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "elevation") (:form . "elevation") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gamma-globin") (:form . "gamma-globin") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "hemoglobinopathy") (:form . "hemoglobinopathies")\n  (:end . 141) (:start . 123) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1256.3.1) (:span 93 98)))\n (:hscopes ((:id . :x1256.3.1) (:span 93 141)))\n (:identifiers (:sid . :s1256.3) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011697@unknown@formal@none@1@S@We previously showed that repression of the beta-globin gene appears to be mediated through two DNA sequences, silencers I and II, and identified a protein termed BP1 which binds to both silencer sequences.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 20) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 109)\n  (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "silencer") (:form . "silencers") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 155)\n  (:start . 148) (:id . 68))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "NN") (:stem . "bp1") (:form . "BP1") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 178)\n  (:start . 173) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 186) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 195)\n  (:start . 187) (:id . 75))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 205)\n  (:start . 196) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1256.4.1) (:span 61 68)))\n (:hscopes ((:id . :x1256.4.1) (:span 26 129)))\n (:identifiers (:sid . :s1256.4) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011698@unknown@formal@none@1@S@In this study, we cloned two cDNAs encoding proteins which bind to an oligonucleotide in silencer I containing a BP1 binding site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "clone") (:form . "cloned") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cdna") (:form . "cDNAs") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 85) (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "silencer") (:form . "silencer") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "bp1") (:form . "BP1") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1256.5) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011700@unknown@formal@none@1@S@We demonstrate that binding of HMG-I(Y) to this oligonucleotide causes bending/flexure of the DNA.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 63) (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "bending/flexure") (:form . "bending/flexure")\n  (:end . 86) (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1256.7) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011701@unknown@formal@none@1@S@HMG-I(Y) also binds to a second oligonucleotide containing a BP1 binding site located in a negative control region upstream of the delta-globin gene, suggesting a role for HMG-I(Y) in repression of adult globin genes.@(((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 47) (:start . 32) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bp1") (:form . "BP1") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "delta-globin") (:form . "delta-globin") (:end . 143)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 148) (:start . 144)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 67))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 180)\n  (:start . 172) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "repression") (:form . "repression") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "globin") (:form . "globin") (:end . 210)\n  (:start . 204) (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 216)\n  (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1256.8.1) (:span 150 160)))\n (:hscopes ((:id . :x1256.8.1) (:span 150 216)))\n (:identifiers (:sid . :s1256.8) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011702@unknown@formal@none@1@S@Expression studies revealed that HMG-I(Y) is ubiquitously expressed in human tissues that do not express beta-globin, being present in 48 of 50 tissues and six hematopoietic cell lines examined.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 27)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 41)\n  (:start . 33) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "RB") (:stem . "ubiquitously") (:form . "ubiquitously") (:end . 57)\n  (:start . 45) (:id . 48))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 123) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 151)\n  (:start . 144) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 173) (:start . 160) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 184)\n  (:start . 179) (:id . 70))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1256.9.1) (:span 93 96)))\n (:nscopes ((:id . :x1256.9.1) (:span 93 116)))\n (:identifiers (:sid . :s1256.9) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011703@unknown@formal@none@1@S@Furthermore, HMG-I(Y) expression is down-regulated during differentiation of primary erythroid cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "down-regulate") (:form . "down-regulated")\n  (:end . 50) (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 73) (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "JJ") (:stem . "erythroid") (:form . "erythroid") (:end . 94)\n  (:start . 85) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 100) (:start . 95)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1256.10) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011704@unknown@formal@none@1@S@We present a model in which HMG-I(Y) alters DNA conformation to allow binding of repressor proteins, and in which the relative amount of HMG-I(Y) helps to determine the repressive state of the beta-globin gene.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "VBZ") (:stem . "alter") (:form . "alters") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 60)\n  (:start . 48) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "repressor") (:form . "repressor") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 126)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HMG-I(Y)") (:form . "HMG-I(Y)") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "VBZ") (:stem . "help") (:form . "helps") (:end . 151)\n  (:start . 146) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "repressive") (:form . "repressive") (:end . 179)\n  (:start . 169) (:id . 71))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 192) (:start . 189)\n  (:id . 74))\n ((:tag . "NN") (:stem . "beta-globin") (:form . "beta-globin") (:end . 204)\n  (:start . 193) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1256.11) (:did . :|9883803|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011705@unknown@formal@none@1@S@Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg).@(((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 95)\n  (:start . 84) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1257.1) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011706@unknown@formal@none@1@S@The anaphylatoxin C3a has been reported to have immunomodulatory effects on a number of different cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "anaphylatoxin") (:form . "anaphylatoxin")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "immunomodulatory") (:form . "immunomodulatory")\n  (:end . 64) (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1257.2) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011707@unknown@formal@none@1@S@In this study we investigated the effects of C3a and C3a(desArg) on gene expression and protein secretion of IL-6 in human PBMCs, either alone or in combination with LPS or IL-1beta.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-6") (:form . "IL-6") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "pbmc") (:form . "PBMCs") (:end . 128)\n  (:start . 123) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 136)\n  (:start . 130) (:id . 65))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 160)\n  (:start . 149) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 172) (:start . 170)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IL-1beta") (:form . "IL-1beta") (:end . 181)\n  (:start . 173) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1257.3) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011708@unknown@formal@none@1@S@C3a or C3a(desArg) alone exhibited no effect on the expression or secretion of IL-6.@(((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "secretion") (:form . "secretion") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1257.4.1) (:span 35 37)))\n (:nscopes ((:id . :x1257.4.1) (:span 35 83)))\n (:identifiers (:sid . :s1257.4) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011710@unknown@formal@none@1@S@Since C3a has been shown to induce PGE2 production by monocytes, and PGE2 has been shown to influence cytokine production, we investigated the potential role of PGE2 in C3a-mediated enhancement of LPS- and IL-1beta-induced IL-6 production.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PGE2") (:form . "PGE2") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 101)\n  (:start . 92) (:id . 60))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 110)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 121)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 138)\n  (:start . 126) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "c3a-mediated") (:form . "C3a-mediated") (:end . 181)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "enhancement") (:form . "enhancement") (:end . 193)\n  (:start . 182) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "LPS-") (:form . "LPS-") (:end . 201) (:start . 197)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "il-1beta-induced") (:form . "IL-1beta-induced")\n  (:end . 222) (:start . 206) (:id . 77))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 227) (:start . 223)\n  (:id . 78))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 238)\n  (:start . 228) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1257.6.1) (:span 143 152)))\n (:hscopes ((:id . :x1257.6.1) (:span 143 238)))\n (:identifiers (:sid . :s1257.6) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011711@unknown@formal@none@1@S@Indomethacin blocked PGE2 release, but had no influence on the observed effects of C3a, suggesting that the effects of C3a on IL-6 production are independent of PGE2 formation by monocytes.@(((:tag . "NNP") (:stem . "Indomethacin") (:form . "Indomethacin") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 25) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 157)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pge2") (:form . "PGE2") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 175)\n  (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 188)\n  (:start . 179) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1257.7.1) (:span 88 98)))\n (:ncues ((:id . :x1257.7.2) (:span 43 45)))\n (:hscopes ((:id . :x1257.7.1) (:span 88 188)))\n (:nscopes ((:id . :x1257.7.2) (:span 43 86)))\n (:identifiers (:sid . :s1257.7) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011712@unknown@formal@none@1@S@Northern blot analysis showed that C3a as well as C3a(desArg) enhanced LPS-induced mRNA levels for IL-6.@(((:tag . "NNP") (:stem . "Northern") (:form . "Northern") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 82)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "IL-6") (:form . "IL-6") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1257.8) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011713@unknown@formal@none@1@S@Pretreatment of PBMCs with pertussis toxin blocked the functions of C3a and C3a(desArg), indicating that the actions of these two molecules are mediated by a G protein-coupled pathway.@(((:tag . "NNP") (:stem . "Pretreatment") (:form . "Pretreatment") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "PBMC") (:form . "PBMCs") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pertussis") (:form . "pertussis") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "toxin") (:form . "toxin") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 64)\n  (:start . 55) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "action") (:form . "actions") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 139)\n  (:start . 130) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 152)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "protein-coupled") (:form . "protein-coupled")\n  (:end . 175) (:start . 160) (:id . 69))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1257.9.1) (:span 89 104)))\n (:hscopes ((:id . :x1257.9.1) (:span 89 183)))\n (:identifiers (:sid . :s1257.9) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011714@unknown@formal@none@1@S@Furthermore, we investigated the effects of C3a and C3a(desArg) on induction of NF-kappaB and activating protein-1 binding.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C3a(desArg)") (:form . "C3a(desArg)") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1257.10) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011715@unknown@formal@none@1@S@Both molecules enhanced LPS-induced NF-kappaB and activating protein-1 binding activity.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "activate") (:form . "activating") (:end . 60)\n  (:start . 50) (:id . 48))\n ((:tag . "NN") (:stem . "protein-1") (:form . "protein-1") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1257.11) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011716@unknown@formal@none@1@S@These results demonstrate the capacity of intact C3a and its circulating des-Arg form to exert immunmodulatory effects in vitro.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "capacity") (:form . "capacity") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NNP") (:stem . "C3a") (:form . "C3a") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "des-arg") (:form . "des-Arg") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VB") (:stem . "exert") (:form . "exert") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immunmodulatory") (:form . "immunmodulatory")\n  (:end . 110) (:start . 95) (:id . 57))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 127)\n  (:start . 122) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1257.12) (:did . :|9886419|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011717@unknown@formal@none@1@S@Differential monocyte adhesion and adhesion molecule expression in venous and arterial endothelial cells.@(((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "venous") (:form . "venous") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "arterial") (:form . "arterial") (:end . 86)\n  (:start . 78) (:id . 52))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 98)\n  (:start . 87) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1258.1) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011718@unknown@formal@none@1@S@We compared U-937 cell adhesion and adhesion molecule expression in human umbilical venous (HUVECs) and arterial (HUAECs) endothelial cells exposed to tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide (LPS).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "venous") (:form . "venous") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "arterial") (:form . "arterial") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "HUAEC") (:form . "HUAECs") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 133)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "VBN") (:stem . "expose") (:form . "exposed") (:end . 147)\n  (:start . 140) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 172)\n  (:start . 166) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 193) (:start . 180) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 76))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 217) (:start . 199) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 222) (:start . 219)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s1258.2) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011720@unknown@formal@none@1@S@Antibody studies demonstrated that in HUVECs at least 75% of the adhesion response is VCAM-1 mediated.@(((:tag . "NN") (:stem . "antibody") (:form . "Antibody") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1258.4) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011721@unknown@formal@none@1@S@Interleukin-1 stimulated U-937 cell adhesion to and VCAM-1 surface expression in both HUVECs and HUAECs.@(((:tag . "NN") (:stem . "interleukin-1") (:form . "Interleukin-1")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 44)\n  (:start . 36) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "NNPS") (:stem . "HUVEC") (:form . "HUVECs") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NNPS") (:stem . "HUAEC") (:form . "HUAECs") (:end . 103)\n  (:start . 97) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1258.5) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011722@unknown@formal@none@1@S@Pyrrolidinedithiocarbamate and the proteasome inhibitor MG-132 blocked TNF- and LPS-stimulated U-937 cell adhesion to HUVECs.@(((:tag . "NNP") (:stem . "Pyrrolidinedithiocarbamate")\n  (:form . "Pyrrolidinedithiocarbamate") (:end . 26) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 44))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 45)\n  (:start . 35) (:id . 45))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 55)\n  (:start . 46) (:id . 46))\n ((:tag . "NN") (:stem . "mg-132") (:form . "MG-132") (:end . 62)\n  (:start . 56) (:id . 47))\n ((:tag . "VBD") (:stem . "block") (:form . "blocked") (:end . 70)\n  (:start . 63) (:id . 48))\n ((:tag . "NN") (:stem . "tnf-") (:form . "TNF-") (:end . 75) (:start . 71)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 94) (:start . 80) (:id . 51))\n ((:tag . "NN") (:stem . "u-937") (:form . "U-937") (:end . 100) (:start . 95)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 105) (:start . 101)\n  (:id . 53))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 114)\n  (:start . 106) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 124)\n  (:start . 118) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1258.6) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011723@unknown@formal@none@1@S@These agents also significantly decreased TNF- and LPS-stimulated increases in HUVEC surface VCAM-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "tnf-") (:form . "TNF-") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lps-stimulated") (:form . "LPS-stimulated")\n  (:end . 65) (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 75)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 92)\n  (:start . 85) (:id . 53))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 99)\n  (:start . 93) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1258.7) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011724@unknown@formal@none@1@S@TNF increased VCAM-1 protein and mRNA in HUVECs that was blocked by pyrrolidinedithiocarbamate.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pyrrolidinedithiocarbamate")\n  (:form . "pyrrolidinedithiocarbamate") (:end . 94) (:start . 68) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1258.8) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011725@unknown@formal@none@1@S@However, neither TNF or LPS stimulated VCAM-1 expression in HUAECs.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HUAEC") (:form . "HUAECs") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x1258.9.1) (:span 9 16 21 23)))\n (:nscopes ((:id . :x1258.9.1) (:span 9 66)))\n (:identifiers (:sid . :s1258.9) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011726@unknown@formal@none@1@S@TNF stimulated expression of both intercellular adhesion molecule-1 and E-selectin in HUVECs, but in HUAECs, only intercellular adhesion molecule-1 was increased.@(((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "stimulate") (:form . "stimulated") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 47) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HUAEC") (:form . "HUAECs") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 127) (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 161)\n  (:start . 152) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1258.10) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011727@unknown@formal@none@1@S@Electrophoretic mobility shift assays demonstrated no difference in the pattern of TNF-stimulated nuclear factor-kappaB activation between HUVECs and HUAECs.@(((:tag . "JJ") (:stem . "electrophoretic") (:form . "Electrophoretic")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 30) (:start . 25)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 37)\n  (:start . 31) (:id . 45))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 50)\n  (:start . 38) (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 53) (:start . 51)\n  (:id . 47))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 64)\n  (:start . 54) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 79)\n  (:start . 72) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tnf-stimulated") (:form . "TNF-stimulated")\n  (:end . 97) (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 105)\n  (:start . 98) (:id . 54))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 119) (:start . 106) (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 130)\n  (:start . 120) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 138)\n  (:start . 131) (:id . 57))\n ((:tag . "NNPS") (:stem . "HUVEC") (:form . "HUVECs") (:end . 145)\n  (:start . 139) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 59))\n ((:tag . "NNPS") (:stem . "HUAEC") (:form . "HUAECs") (:end . 156)\n  (:start . 150) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1258.11.1) (:span 51 53)))\n (:nscopes ((:id . :x1258.11.1) (:span 51 156)))\n (:identifiers (:sid . :s1258.11) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011728@unknown@formal@none@1@S@These studies demonstrate a novel and striking insensitivity of arterial endothelium to the effects of TNF and LPS and indicate a dissociation between the ability of HUAECs to upregulate nuclear factor-kappaB and VCAM-1.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "insensitivity") (:form . "insensitivity")\n  (:end . 60) (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "arterial") (:form . "arterial") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "endothelium") (:form . "endothelium") (:end . 84)\n  (:start . 73) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 127)\n  (:start . 119) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 142)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "huaec") (:form . "HUAECs") (:end . 172)\n  (:start . 166) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 69))\n ((:tag . "VB") (:stem . "upregulate") (:form . "upregulate") (:end . 186)\n  (:start . 176) (:id . 70))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 194)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 208) (:start . 195) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 219)\n  (:start . 213) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1258.12.1) (:span 119 127)))\n (:hscopes ((:id . :x1258.12.1) (:span 119 219)))\n (:identifiers (:sid . :s1258.12) (:did . :|9887050|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011730@unknown@formal@none@1@S@The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "principal") (:form . "principal") (:end . 51)\n  (:start . 42) (:id . 52))\n ((:tag . "NN") (:stem . "initiator") (:form . "initiator") (:end . 61)\n  (:start . 52) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "coagulation") (:form . "coagulation") (:end . 76)\n  (:start . 65) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 97)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 110)\n  (:start . 98) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 130) (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1259.2) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011731@unknown@formal@none@1@S@Both conditions are promoted by lysophosphatidylcholine (lysoPC).@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lysophosphatidylcholine")\n  (:form . "lysophosphatidylcholine") (:end . 55) (:start . 32) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 63)\n  (:start . 57) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1259.3) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011732@unknown@formal@none@1@S@We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "observe") (:form . "observed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "micromol/l") (:form . "micromol/L") (:end . 64)\n  (:start . 54) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "RB") (:stem . "dose-dependently") (:form . "dose-dependently")\n  (:end . 82) (:start . 66) (:id . 56))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 121)\n  (:start . 112) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 156) (:start . 138) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1259.4) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011733@unknown@formal@none@1@S@Lysophosphatidylethanolamine (lysoPE) and other lysophospholipids did not affect LPS-induced TF activity of human monocytes.@(((:tag . "NNP") (:stem . "Lysophosphatidylethanolamine")\n  (:form . "Lysophosphatidylethanolamine") (:end . 28) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "lysoPE") (:form . "lysoPE") (:end . 36)\n  (:start . 30) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lysophospholipid") (:form . "lysophospholipids")\n  (:end . 65) (:start . 48) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 69) (:start . 66)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 73) (:start . 70)\n  (:id . 50))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 80)\n  (:start . 74) (:id . 51))\n ((:tag . "JJ") (:stem . "lps-induced") (:form . "LPS-induced") (:end . 92)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "tf") (:form . "TF") (:end . 95) (:start . 93)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 104)\n  (:start . 96) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 113)\n  (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1259.5.1) (:span 70 73)))\n (:nscopes ((:id . :x1259.5.1) (:span 70 123)))\n (:identifiers (:sid . :s1259.5) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011734@unknown@formal@none@1@S@TF antigen expression as elicited by LPS was also lowered by lysoPC.@(((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "antigen") (:form . "antigen") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "lower") (:form . "lowered") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1259.6) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011735@unknown@formal@none@1@S@Phospholipid analyses indicated a selective increase in the lysoPC content of the monocytes after preincubation with the lysophospholipid.@(((:tag . "NNP") (:stem . "Phospholipid") (:form . "Phospholipid") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 31)\n  (:start . 22) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 66)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "preincubation") (:form . "preincubation")\n  (:end . 111) (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lysophospholipid") (:form . "lysophospholipid")\n  (:end . 137) (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1259.7) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011736@unknown@formal@none@1@S@LysoPC inhibited the TF activity of Mono Mac-6 cells to a similar extent as in the monocytes.@(((:tag . "NNP") (:stem . "LysoPC") (:form . "LysoPC") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Mono") (:form . "Mono") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Mac-6") (:form . "Mac-6") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1259.8) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011737@unknown@formal@none@1@S@LPS binding to plasma membrane receptors and internalization of LPS into monocytes were not affected by lysoPC.@(((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "internalization") (:form . "internalization")\n  (:end . 60) (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1259.9.1) (:span 88 91)))\n (:nscopes ((:id . :x1259.9.1) (:span 0 110)))\n (:identifiers (:sid . :s1259.9) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011738@unknown@formal@none@1@S@In contrast, LPS-mediated nuclear binding of nuclear factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "factor-kappab/rel") (:form . "factor-kappaB/Rel")\n  (:end . 70) (:start . 53) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "tf-specific") (:form . "TF-specific") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "kappab") (:form . "kappaB") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 99) (:start . 95)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 123)\n  (:start . 117) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1259.10) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011740@unknown@formal@none@1@S@Preincubation with lysoPC increased monocytic cAMP levels.@(((:tag . "NN") (:stem . "preincubation") (:form . "Preincubation")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 45)\n  (:start . 36) (:id . 46))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1259.12) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011741@unknown@formal@none@1@S@Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adenylyl") (:form . "adenylyl") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "cyclase") (:form . "cyclase") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pretreatment") (:form . "pretreatment") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "2'-deoxy-3'-adenosine")\n  (:form . "2'-deoxy-3'-adenosine") (:end . 73) (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "monophosphate") (:form . "monophosphate")\n  (:end . 87) (:start . 74) (:id . 50))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 97)\n  (:start . 88) (:id . 51))\n ((:tag . "VBD") (:stem . "reverse") (:form . "reversed") (:end . 106)\n  (:start . 98) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 121)\n  (:start . 111) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 127) (:start . 125)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 57))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 145)\n  (:start . 137) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 155)\n  (:start . 149) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1259.13) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011742@unknown@formal@none@1@S@In conclusion, lysoPC markedly decreases LPS-mediated TF expression of human monocytes, the effect probably being mediated by both transcriptional and posttranscriptional mechanisms.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lysopc") (:form . "lysoPC") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "lps-mediated") (:form . "LPS-mediated") (:end . 53)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "TF") (:form . "TF") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 113) (:start . 108)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 146) (:start . 131) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "posttranscriptional")\n  (:form . "posttranscriptional") (:end . 170) (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 181)\n  (:start . 171) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1259.14.1) (:span 99 107)))\n (:hscopes ((:id . :x1259.14.1) (:span 99 181)))\n (:identifiers (:sid . :s1259.14) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011743@unknown@formal@none@1@S@LysoPC may thus attenuate activation of coagulation during inflammation and atherosclerosis.@(((:tag . "NNP") (:stem . "LysoPC") (:form . "LysoPC") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "attenuate") (:form . "attenuate") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "coagulation") (:form . "coagulation") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 71)\n  (:start . 59) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 51))\n ((:tag . "NN") (:stem . "atherosclerosis") (:form . "atherosclerosis")\n  (:end . 91) (:start . 76) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x1259.15.1) (:span 7 10)))\n (:hscopes ((:id . :x1259.15.1) (:span 7 91)))\n (:identifiers (:sid . :s1259.15) (:did . :|9888865|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011744@unknown@formal@none@1@S@Intranuclear targeted delivery of functional NF-kappaB by 70 kDa heat shock protein.@(((:tag . "JJ") (:stem . "intranuclear") (:form . "Intranuclear") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "target") (:form . "targeted") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "delivery") (:form . "delivery") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 60) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1260.1) (:did . :|9889197|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011745@unknown@formal@none@1@S@The 70 kDa heat shock protein (Hsp70) is a highly conserved, ubiquitous protein involved in chaperoning proteins to various cellular organelles.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Hsp70") (:form . "Hsp70") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 52))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 49)\n  (:start . 43) (:id . 53))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 59)\n  (:start . 50) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 71)\n  (:start . 61) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 57))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 88)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "chaperon") (:form . "chaperoning") (:end . 103)\n  (:start . 92) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 132)\n  (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "organelle") (:form . "organelles") (:end . 143)\n  (:start . 133) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1260.2) (:did . :|9889197|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011746@unknown@formal@none@1@S@Here we show that when added exogenously to cells, Hsp70 is readily imported into both cytoplasmic and nuclear compartments in a cell-type-specific fashion.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "exogenously") (:form . "exogenously") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Hsp70") (:form . "Hsp70") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "VBN") (:stem . "import") (:form . "imported") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 123)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cell-type-specific") (:form . "cell-type-specific")\n  (:end . 147) (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "fashion") (:form . "fashion") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1260.3) (:did . :|9889197|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011747@unknown@formal@none@1@S@We exploited this ability of Hsp70 to deliver NF-kappaB, a key transcriptional regulator of inflammatory responses.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "exploit") (:form . "exploited") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Hsp70") (:form . "Hsp70") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "deliver") (:form . "deliver") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 78) (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 104)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "response") (:form . "responses") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1260.4) (:did . :|9889197|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011748@unknown@formal@none@1@S@We demonstrate that a fusion protein composed of a C-terminal Hsp70 peptide and the p50 subunit of NF-kappaB was directed into the nucleus of cells, could bind DNA specifically, and activated Igkappa expression and TNFalpha production.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "Hsp70") (:form . "Hsp70") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p50") (:form . "p50") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 138)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 163) (:start . 160)\n  (:id . 70))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 176)\n  (:start . 164) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 191)\n  (:start . 182) (:id . 74))\n ((:tag . "NNP") (:stem . "Igkappa") (:form . "Igkappa") (:end . 199)\n  (:start . 192) (:id . 75))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 210)\n  (:start . 200) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "TNFalpha") (:form . "TNFalpha") (:end . 223)\n  (:start . 215) (:id . 78))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 234)\n  (:start . 224) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1260.5) (:did . :|9889197|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011750@unknown@formal@none@1@S@CD2 signalling induces phosphorylation of CREB in primary lymphocytes.@(((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 38) (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 69)\n  (:start . 58) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1261.1) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011751@unknown@formal@none@1@S@Promoter sequences responsive to cyclic AMP (cAMP) are found in a number of cellular genes, and bind transcription factors of the cAMP response element binding protein (CREB)/activating transcription factor-1 (ATF-1) family.@(((:tag . "NN") (:stem . "promoter") (:form . "Promoter") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 39)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "AMP") (:form . "AMP") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "cAMP") (:form . "cAMP") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "bind") (:form . "bind") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 114) (:start . 101) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 143)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 167)\n  (:start . 160) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "CREB)/activating") (:form . "CREB)/activating")\n  (:end . 185) (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 199) (:start . 186) (:id . 73))\n ((:tag . "NN") (:stem . "factor-1") (:form . "factor-1") (:end . 208)\n  (:start . 200) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 75))\n ((:tag . "NN") (:stem . "atf-1") (:form . "ATF-1") (:end . 215)\n  (:start . 210) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 223)\n  (:start . 217) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1261.2) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011752@unknown@formal@none@1@S@We have used a human T-lymphotropic virus type 1 (HTLV-1) model of cAMP response element (CRE) transcription to investigate the influence of lymphocyte activation on transcription from homologous regions in the viral promoter.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "t-lymphotropic") (:form . "T-lymphotropic")\n  (:end . 35) (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HTLV-1") (:form . "HTLV-1") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 80)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 88)\n  (:start . 81) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "CRE") (:form . "CRE") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 108) (:start . 95) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 63))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 123)\n  (:start . 112) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 137)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 162)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 179) (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 195)\n  (:start . 185) (:id . 73))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 203)\n  (:start . 196) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 216)\n  (:start . 211) (:id . 77))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 225)\n  (:start . 217) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1261.3) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011753@unknown@formal@none@1@S@We previously demonstrated increased HTLV-1 transcription following CD2 but not CD3 receptor cross-linking.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "htlv-1") (:form . "HTLV-1") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 57) (:start . 44) (:id . 47))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 67)\n  (:start . 58) (:id . 48))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 71) (:start . 68)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 92)\n  (:start . 84) (:id . 53))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 106) (:start . 93) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1261.4.1) (:span 76 79)))\n (:nscopes ((:id . :x1261.4.1) (:span 76 106)))\n (:identifiers (:sid . :s1261.4) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011754@unknown@formal@none@1@S@We hypothesized that this increased viral transcription was mediated, in part, through the phosphorylation of CREB.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 55) (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 106) (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1261.5.1) (:span 3 15)))\n (:hscopes ((:id . :x1261.5.1) (:span 3 114)))\n (:identifiers (:sid . :s1261.5) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011755@unknown@formal@none@1@S@Therefore, we investigated CD2 and CD3 receptor-mediated signalling in primary human peripheral blood mononuclear cells (PBMC).@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "receptor-mediated") (:form . "receptor-mediated")\n  (:end . 56) (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 101) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 113)\n  (:start . 102) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 119)\n  (:start . 114) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1261.6) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011756@unknown@formal@none@1@S@CD2, but not CD3, cross-linking increased cAMP detected by competitive enzyme-linked immunosorbent assay (ELISA) approximately fourfold.@(((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 8) (:start . 5)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 31) (:start . 18) (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "camp") (:form . "cAMP") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "competitive") (:form . "competitive") (:end . 70)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "enzyme-linked") (:form . "enzyme-linked")\n  (:end . 84) (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "immunosorbent") (:form . "immunosorbent")\n  (:end . 98) (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ELISA") (:form . "ELISA") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 126) (:start . 113) (:id . 60))\n ((:tag . "RB") (:stem . "fourfold") (:form . "fourfold") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1261.7.1) (:span 9 12)))\n (:nscopes ((:id . :x1261.7.1) (:span 9 16)))\n (:identifiers (:sid . :s1261.7) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011757@unknown@formal@none@1@S@CD2 cross-linking concurrently increased phosphorylation of CREB detected by immunoblot assay eightfold.@(((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "concurrently") (:form . "concurrently") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 40)\n  (:start . 31) (:id . 45))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 56) (:start . 41) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 64) (:start . 60)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 73)\n  (:start . 65) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 50))\n ((:tag . "NN") (:stem . "immunoblot") (:form . "immunoblot") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 93) (:start . 88)\n  (:id . 52))\n ((:tag . "RB") (:stem . "eightfold") (:form . "eightfold") (:end . 103)\n  (:start . 94) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1261.8) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011758@unknown@formal@none@1@S@Consistent with post-translational regulation, no change in total level of CREB protein was observed.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "post-translational") (:form . "post-translational")\n  (:end . 34) (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 45)\n  (:start . 35) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 56)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 65) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1261.9.1) (:span 47 49)))\n (:nscopes ((:id . :x1261.9.1) (:span 47 100)))\n (:identifiers (:sid . :s1261.9) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011760@unknown@formal@none@1@S@Both CD2 and CD3 cross-linking increased binding of nuclear proteins to a radiolabelled CRE oligonucleotide probe in electrophoretic mobility shift assays suggesting that lymphocyte activation enhances binding independently of phosphorylation of CREB at serine 133.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cd3") (:form . "CD3") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "radiolabelle") (:form . "radiolabelled")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "cre") (:form . "CRE") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "oligonucleotide") (:form . "oligonucleotide")\n  (:end . 107) (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "probe") (:form . "probe") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 132) (:start . 117) (:id . 59))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 147)\n  (:start . 142) (:id . 61))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 154)\n  (:start . 148) (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 170) (:start . 166)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymphocyte") (:form . "lymphocyte") (:end . 181)\n  (:start . 171) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 192)\n  (:start . 182) (:id . 66))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 201)\n  (:start . 193) (:id . 67))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 209)\n  (:start . 202) (:id . 68))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 223) (:start . 210) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 70))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 242) (:start . 227) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 245) (:start . 243)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 250) (:start . 246)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 253) (:start . 251)\n  (:id . 74))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 260)\n  (:start . 254) (:id . 75))\n ((:tag . "CD") (:stem . "133") (:form . "133") (:end . 264) (:start . 261)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1261.11.1) (:span 155 165)))\n (:hscopes ((:id . :x1261.11.1) (:span 155 264)))\n (:identifiers (:sid . :s1261.11) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011761@unknown@formal@none@1@S@These data indicate specific modulation of the CREB/ATF-1 family of transcription factors by the CD2 signalling pathway and suggest CD2 receptor modulation of CRE-mediated transcription following ligand engagement (e.g. cell-to-cell contact).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "creb/atf-1") (:form . "CREB/ATF-1") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 64)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 81) (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signalling") (:form . "signalling") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 131)\n  (:start . 124) (:id . 60))\n ((:tag . "NN") (:stem . "cd2") (:form . "CD2") (:end . 135) (:start . 132)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "cre-mediated") (:form . "CRE-mediated") (:end . 171)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 185) (:start . 172) (:id . 66))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 195)\n  (:start . 186) (:id . 67))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 202)\n  (:start . 196) (:id . 68))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 213)\n  (:start . 203) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 215) (:start . 214)\n  (:id . 70))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 219) (:start . 215)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cell-to-cell") (:form . "cell-to-cell") (:end . 232)\n  (:start . 220) (:id . 72))\n ((:tag . "NN") (:stem . "contact") (:form . "contact") (:end . 240)\n  (:start . 233) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 241) (:start . 240)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1261.12.1) (:span 124 131))\n  ((:id . :x1261.12.2) (:span 11 19)))\n (:hscopes ((:id . :x1261.12.1) (:span 124 241))\n  ((:id . :x1261.12.2) (:span 11 119)))\n (:identifiers (:sid . :s1261.12) (:did . :|9893043|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011762@unknown@formal@none@1@S@Anoxia/reoxygenation-induced tolerance with respect to polymorphonuclear leukocyte adhesion to cultured endothelial cells.@(((:tag . "JJ") (:stem . "anoxia/reoxygenation-induced")\n  (:form . "Anoxia/reoxygenation-induced") (:end . 28) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 38)\n  (:start . 29) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 44))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 51)\n  (:start . 44) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 72) (:start . 55) (:id . 47))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 82)\n  (:start . 73) (:id . 48))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 91)\n  (:start . 83) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 103)\n  (:start . 95) (:id . 51))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 115)\n  (:start . 104) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1262.1) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011763@unknown@formal@none@1@S@A nuclear factor-kappaB-mediated phenomenon.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "factor-kappab-mediated")\n  (:form . "factor-kappaB-mediated") (:end . 32) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s1262.2) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011764@unknown@formal@none@1@S@Exposing human umbilical vein endothelial cells (HUVECs) to anoxia/reoxygenation (A/R) results in an increase in polymorphonuclear leukocyte (PMN) adhesion to HUVECs.@(((:tag . "VBG") (:stem . "expose") (:form . "Exposing") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "anoxia/reoxygenation")\n  (:form . "anoxia/reoxygenation") (:end . 80) (:start . 60) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 130) (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1262.3) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011765@unknown@formal@none@1@S@This A/R-induced hyperadhesion is completely prevented by a previous (24 hours earlier) exposure of HUVECs to A/R.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "a/r-induced") (:form . "A/R-induced") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "hyperadhesion") (:form . "hyperadhesion")\n  (:end . 30) (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 45))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "exposure") (:form . "exposure") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1262.4) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011766@unknown@formal@none@1@S@This phenomenon has been termed "A/R tolerance."@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "\\"A/R") (:form . "\\"A/R") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "''") (:stem . "''") (:form . "\\"") (:end . 48) (:start . 47)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1262.5) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011767@unknown@formal@none@1@S@Exposing HUVECs to A/R induces an increase in nuclear factor kappaB (NF-kappaB) in HUVEC nuclei within 4 hours.@(((:tag . "VBG") (:stem . "expose") (:form . "Exposing") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "induce") (:form . "induces") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNP") (:stem . "kappaB") (:form . "kappaB") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVEC") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1262.6) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011768@unknown@formal@none@1@S@Interfering with either NF-kappaB activation (proteasome inhibitor) or translocation (double-stranded oligonucleotides containing NF-kappaB binding sequence) prevents the development of A/R tolerance (ie, the increase in A/R-induced PMN adhesion to HUVECs is the same after the first and second A/R challenges).@(((:tag . "VBG") (:stem . "interfere") (:form . "Interfering") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "proteasome") (:form . 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"binding") (:form . "binding") (:end . 147)\n  (:start . 140) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 156)\n  (:start . 148) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 166)\n  (:start . 158) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 62))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 182)\n  (:start . 171) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 189) (:start . 186)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 199)\n  (:start . 190) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 67))\n ((:tag . "FW") (:stem . "ie") (:form . "ie") (:end . 203) (:start . 201)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 208) (:start . 205)\n  (:id . 70))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 217)\n  (:start . 209) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "a/r-induced") (:form . "A/R-induced") (:end . 232)\n  (:start . 221) (:id . 73))\n ((:tag . "NNP") (:stem . "PMN") (:form . "PMN") (:end . 236) (:start . 233)\n  (:id . 74))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 245)\n  (:start . 237) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 248) (:start . 246)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 255)\n  (:start . 249) (:id . 77))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 258) (:start . 256)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 262) (:start . 259)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 267) (:start . 263)\n  (:id . 80))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 273)\n  (:start . 268) (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 277) (:start . 274)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 283)\n  (:start . 278) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 287) (:start . 284)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 294)\n  (:start . 288) (:id . 85))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 298) (:start . 295)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "challenge") (:form . "challenges") (:end . 309)\n  (:start . 299) (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 310) (:start . 309)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 311) (:start . 310)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s1262.7) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011770@unknown@formal@none@1@S@Inhibition of NO synthase (NOS) during the second A/R challenge prevents the development of A/R tolerance with respect to PMN adhesion.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "synthase") (:form . "synthase") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "nos") (:form . "NOS") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1262.9) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011771@unknown@formal@none@1@S@However, while HUVECs contained endothelial NOS protein, no inducible NOS was detected in either tolerant or nontolerant cells.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 43)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "nos") (:form . "NOS") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "nos") (:form . "NOS") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "tolerant") (:form . "tolerant") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nontolerant") (:form . "nontolerant") (:end . 120)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1262.10.1) (:span 57 59)))\n (:nscopes ((:id . :x1262.10.1) (:span 57 126)))\n (:identifiers (:sid . :s1262.10) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011772@unknown@formal@none@1@S@Further studies indicated that inhibition of GTP-cyclohydrolase I (an enzyme involved in de novo synthesis of an important cofactor for NOS activity, tetrahydrobiopterin) prevented the generation of NO in A/R-tolerant cells.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GTP-cyclohydrolase") (:form . "GTP-cyclohydrolase")\n  (:end . 63) (:start . 45) (:id . 48))\n ((:tag . "CD") (:stem . "i") (:form . "I") (:end . 65) (:start . 64)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "NOS") (:form . "NOS") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "tetrahydrobiopterin")\n  (:form . "tetrahydrobiopterin") (:end . 169) (:start . 150) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "prevent") (:form . "prevented") (:end . 180)\n  (:start . 171) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 195)\n  (:start . 185) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 71))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 201) (:start . 199)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "a/r-tolerant") (:form . "A/R-tolerant") (:end . 217)\n  (:start . 205) (:id . 74))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 223)\n  (:start . 218) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1262.11.1) (:span 16 30)))\n (:hscopes ((:id . :x1262.11.1) (:span 16 223)))\n (:identifiers (:sid . :s1262.11) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011773@unknown@formal@none@1@S@Extracellular generation of NO (NO donor) did not effect the hyperadhesion response induced by the initial A/R challenge.@(((:tag . "JJ") (:stem . "extracellular") (:form . "Extracellular")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "donor") (:form . "donor") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VB") (:stem . "effect") (:form . "effect") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hyperadhesion") (:form . "hyperadhesion")\n  (:end . 74) (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1262.12.1) (:span 46 49)))\n (:nscopes ((:id . :x1262.12.1) (:span 46 120)))\n (:identifiers (:sid . :s1262.12) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011774@unknown@formal@none@1@S@A/R also induced an oxidant stress in naive HUVECs, but not in A/R-tolerant HUVECs.@(((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "naive") (:form . "naive") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "huvec") (:form . "HUVECs") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "a/r-tolerant") (:form . "A/R-tolerant") (:end . 75)\n  (:start . 63) (:id . 55))\n ((:tag . "NNP") (:stem . "HUVEC") (:form . "HUVECs") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1262.13.1) (:span 56 59)))\n (:nscopes ((:id . :x1262.13.1) (:span 56 82)))\n (:identifiers (:sid . :s1262.13) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011775@unknown@formal@none@1@S@Inhibition of NOS during the second A/R insult results in the generation of an oxidant stress similar to that observed after the first A/R challenge.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NOS") (:form . "NOS") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "insult") (:form . "insult") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1262.14) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011776@unknown@formal@none@1@S@Taken together, the findings of the present study are consistent with a role for NF-kappaB in the development of A/R tolerance (with respect to PMN adhesion), perhaps by transcriptional regulation of GTP-cyclohydrolase.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 109)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "tolerance") (:form . "tolerance") (:end . 126)\n  (:start . 117) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 140)\n  (:start . 133) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 156)\n  (:start . 148) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 71))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 166)\n  (:start . 159) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 169) (:start . 167)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 185) (:start . 170) (:id . 74))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 196)\n  (:start . 186) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "GTP-cyclohydrolase") (:form . "GTP-cyclohydrolase")\n  (:end . 218) (:start . 200) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1262.15) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011777@unknown@formal@none@1@S@The increased NO production during the second A/R insult reduces PMN adhesion most likely by reducing the intracellular oxidant stress induced by A/R.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "no") (:form . "NO") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "a/r") (:form . "A/R") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "insult") (:form . "insult") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 119) (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "oxidant") (:form . "oxidant") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 134)\n  (:start . 128) (:id . 61))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "A/R") (:form . "A/R") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x1262.16.1) (:span 83 89)))\n (:hscopes ((:id . :x1262.16.1) (:span 83 149)))\n (:identifiers (:sid . :s1262.16) (:did . :|9915779|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011778@unknown@formal@none@1@S@Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells.@(((:tag . "NN") (:stem . "role") (:form . "Role") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr-2") (:form . "Egr-2") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Fas") (:form . "Fas") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "JJ") (:stem . "double-negative") (:form . "double-negative")\n  (:end . 91) (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "lpr") (:form . "lpr") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gld") (:form . "gld") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1263.1) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011780@unknown@formal@none@1@S@The aberrant CD4(-)CD8(-) T cells from lpr/lpr and gld/gld mice, which have mutations in the genes encoding Fas and FasL, respectively, have an activated phenotype and constitutively express high levels of fasL mRNA, prompting us to ask what role if any the FLRE and Egr family proteins have in this aberrant expression of fasL.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "CD4(-)CD8(-)") (:form . "CD4(-)CD8(-)") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lpr/lpr") (:form . 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5011781@unknown@formal@none@1@S@Unstimulated MRL-lpr/lpr and C3H-gld/gld CD4(-)CD8(-) T cells constitutively contained high levels of two proteins that bound to the FLRE.@(((:tag . "JJ") (:stem . "unstimulated") (:form . "Unstimulated") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "MRL-lpr/lpr") (:form . "MRL-lpr/lpr") (:end . 24)\n  (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "c3h-gld/gld") (:form . "C3H-gld/gld") (:end . 40)\n  (:start . 29) (:id . 45))\n ((:tag . "NNP") (:stem . "CD4(-)CD8(-)") (:form . "CD4(-)CD8(-)") (:end . 53)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 55) (:start . 54)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 48))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 76) (:start . 62) (:id . 49))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 86)\n  (:start . 77) (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 91) (:start . 87)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 98)\n  (:start . 92) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 105) (:start . 102)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 114)\n  (:start . 106) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 125)\n  (:start . 120) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "flre") (:form . "FLRE") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1263.4) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011782@unknown@formal@none@1@S@Supershift analysis revealed these proteins to be Egr-1 and Egr-2 (Krox-20); Egr-3 was not detected.@(((:tag . "NNP") (:stem . "Supershift") (:form . "Supershift") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "egr-2") (:form . "Egr-2") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Krox-20") (:form . "Krox-20") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Egr-3") (:form . "Egr-3") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1263.5.1) (:span 87 90)))\n (:nscopes ((:id . :x1263.5.1) (:span 77 99)))\n (:identifiers (:sid . :s1263.5) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011783@unknown@formal@none@1@S@Activation of normal lymph node cells resulted in increased expression of Egr-1, -2, and -3.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Egr-1") (:form . "Egr-1") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "CD") (:stem . "-2") (:form . "-2") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "CD") (:stem . "-3") (:form . "-3") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1263.6) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011784@unknown@formal@none@1@S@As with egr-3, expression of egr-2 was blocked by cyclosporin A.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "egr-3") (:form . "egr-3") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 25)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "egr-2") (:form . "egr-2") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cyclosporin") (:form . "cyclosporin") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1263.7) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011785@unknown@formal@none@1@S@Although overexpressed Egr-1 was ineffective, overexpressed Egr-2 was as potent as Egr-3 in inducing fasL promoter-dependent reporter constructs in T cell hybridomas and HeLa cells, and both up-regulated endogenous fasL mRNA in HeLa cells.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 22) (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "egr-1") (:form . "Egr-1") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 44)\n  (:start . 33) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 59) (:start . 46) (:id . 48))\n ((:tag . "NN") (:stem . "egr-2") (:form . "Egr-2") (:end . 65) (:start . 60)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 50))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "egr-3") (:form . "Egr-3") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 100)\n  (:start . 92) (:id . 56))\n ((:tag . "NN") (:stem . "fasl") (:form . "fasL") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "promoter-dependent") (:form . "promoter-dependent")\n  (:end . 124) (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 144)\n  (:start . 134) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 149) (:start . 148)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "hybridoma") (:form . "hybridomas") (:end . 165)\n  (:start . 155) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 174) (:start . 170)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 180)\n  (:start . 175) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 190) (:start . 186)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "up-regulate") (:form . "up-regulated") (:end . 203)\n  (:start . 191) (:id . 71))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 214)\n  (:start . 204) (:id . 72))\n ((:tag . "NN") (:stem . "fasl") (:form . "fasL") (:end . 219) (:start . 215)\n  (:id . 73))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 224) (:start . 220)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 227) (:start . 225)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HeLa") (:form . "HeLa") (:end . 232) (:start . 228)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 238)\n  (:start . 233) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1263.8) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011786@unknown@formal@none@1@S@FasL-dependent reporter constructs in MRL-lpr/lpr and C3H-gld/gld CD4(-)CD8(-) T cells were constitutively active, and this activity was largely prevented by mutation of the critical Egr family binding element.@(((:tag . "JJ") (:stem . "fasl-dependent") (:form . "FasL-dependent")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 34)\n  (:start . 24) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MRL-lpr/lpr") (:form . "MRL-lpr/lpr") (:end . 49)\n  (:start . 38) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "c3h-gld/gld") (:form . "C3H-gld/gld") (:end . 65)\n  (:start . 54) (:id . 48))\n ((:tag . "NNP") (:stem . "CD4(-)CD8(-)") (:form . "CD4(-)CD8(-)") (:end . 78)\n  (:start . 66) (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 80) (:start . 79)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 86) (:start . 81)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 52))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 106) (:start . 92) (:id . 53))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 113)\n  (:start . 107) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 123) (:start . 119)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 132)\n  (:start . 124) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 136) (:start . 133)\n  (:id . 59))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 144)\n  (:start . 137) (:id . 60))\n ((:tag . "VBN") (:stem . "prevent") (:form . "prevented") (:end . 154)\n  (:start . 145) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 157) (:start . 155)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 166)\n  (:start . 158) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 182)\n  (:start . 174) (:id . 66))\n ((:tag . "NNP") (:stem . "Egr") (:form . "Egr") (:end . 186) (:start . 183)\n  (:id . 67))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 193)\n  (:start . 187) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 201)\n  (:start . 194) (:id . 69))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 209)\n  (:start . 202) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1263.9) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011787@unknown@formal@none@1@S@Thus, Egr-2, in addition to Egr-3, regulates FasL expression in activated normal T cells, and Egr-2 is likely to play a direct role in aberrant fasL up-regulation in lpr/lpr and gld/gld CD4(-)CD8(-) T cells.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Egr-2") (:form . "Egr-2") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Egr-3") (:form . "Egr-3") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 44)\n  (:start . 35) (:id . 51))\n ((:tag . "NNP") (:stem . "FasL") (:form . "FasL") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 60)\n  (:start . 50) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 73)\n  (:start . 64) (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "egr-2") (:form . "Egr-2") (:end . 99) (:start . 94)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 109)\n  (:start . 103) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 64))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 117) (:start . 113)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 126)\n  (:start . 120) (:id . 67))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 131) (:start . 127)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "aberrant") (:form . "aberrant") (:end . 143)\n  (:start . 135) (:id . 70))\n ((:tag . "NN") (:stem . "fasl") (:form . "fasL") (:end . 148) (:start . 144)\n  (:id . 71))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 162) (:start . 149) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 73))\n ((:tag . "NN") (:stem . "lpr/lpr") (:form . "lpr/lpr") (:end . 173)\n  (:start . 166) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gld/gld") (:form . "gld/gld") (:end . 185)\n  (:start . 178) (:id . 76))\n ((:tag . "JJ") (:stem . "CD4(-)CD8(-)") (:form . "CD4(-)CD8(-)") (:end . 198)\n  (:start . 186) (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 200) (:start . 199)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 206)\n  (:start . 201) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1263.10.1) (:span 103 109)))\n (:hscopes ((:id . :x1263.10.1) (:span 94 206)))\n (:identifiers (:sid . :s1263.10) (:did . :|9915863|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011788@unknown@formal@none@1@S@Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins.@(((:tag . "NN") (:stem . "involvement") (:form . "Involvement") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 32) (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 47)\n  (:start . 41) (:id . 46))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interleukin-8") (:form . "interleukin-8")\n  (:end . 73) (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 84)\n  (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 103)\n  (:start . 94) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "polymorphonuclear") (:form . "polymorphonuclear")\n  (:end . 125) (:start . 108) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 56))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 142)\n  (:start . 132) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 166) (:start . 148) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 169) (:start . 167)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Mycoplasma") (:form . "Mycoplasma") (:end . 180)\n  (:start . 170) (:id . 61))\n ((:tag . "NNS") (:stem . "fermentan") (:form . "fermentans") (:end . 191)\n  (:start . 181) (:id . 62))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 200)\n  (:start . 192) (:id . 63))\n ((:tag . "NNS") (:stem . "lipoprotein") (:form . "lipoproteins") (:end . 213)\n  (:start . 201) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1264.1) (:did . :|9916078|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011790@unknown@formal@none@1@S@IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction.@(((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "notably") (:form . "notably") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lipopolysaccharide") (:form . "lipopolysaccharide")\n  (:end . 107) (:start . 89) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 125)\n  (:start . 119) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 155)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . "NNS") (:stem . "agent") (:form . "agents") (:end . 177)\n  (:start . 171) (:id . 71))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 185)\n  (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 200)\n  (:start . 191) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1264.3) (:did . :|9916078|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011791@unknown@formal@none@1@S@In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Mycoplasma") (:form . "Mycoplasma") (:end . 39)\n  (:start . 29) (:id . 49))\n ((:tag . "NNS") (:stem . "fermentan") (:form . "fermentans") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "lipid-associated") (:form . "lipid-associated")\n  (:end . 67) (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LAMPf") (:form . "LAMPf") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 181) (:start . 179)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 197)\n  (:start . 191) (:id . 77))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 200) (:start . 198)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 204) (:start . 201)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1264.4) (:did . :|9916078|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011792@unknown@formal@none@1@S@It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "monocytic") (:form . "monocytic") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NNP") (:stem . "LPS") (:form . "LPS") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LAMPf") (:form . "LAMPf") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 156)\n  (:start . 147) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 171)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 182)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 191)\n  (:start . 183) (:id . 71))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 198)\n  (:start . 192) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "mitogen-activated") (:form . "mitogen-activated")\n  (:end . 223) (:start . 206) (:id . 75))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 231)\n  (:start . 224) (:id . 76))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 238)\n  (:start . 232) (:id . 77))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 247)\n  (:start . 239) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1264.5) (:did . :|9916078|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011793@unknown@formal@none@1@S@By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "PD-98059") (:form . "PD-98059") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SB203580") (:form . "SB203580") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MEK1") (:form . "MEK1") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ERK1/2") (:form . "ERK1/2") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 64))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 127)\n  (:start . 115) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 149)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 70))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 159) (:start . 155)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ERK1/2") (:form . "ERK1/2") (:end . 166)\n  (:start . 160) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 73))\n ((:tag . "NN") (:stem . "p38") (:form . "p38") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "cascade") (:form . "cascades") (:end . 183)\n  (:start . 175) (:id . 75))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 188) (:start . 184)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 190) (:start . 189)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 194) (:start . 191)\n  (:id . 78))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 199) (:start . 195)\n  (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 81))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 217)\n  (:start . 207) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 83))\n ((:tag . "NN") (:stem . "il-8") (:form . "IL-8") (:end . 225) (:start . 221)\n  (:id . 84))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 228) (:start . 226)\n  (:id . 85))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 238)\n  (:start . 229) (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 87))\n ((:tag . "NN") (:stem . "pmn") (:form . "PMN") (:end . 246) (:start . 243)\n  (:id . 88))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 257)\n  (:start . 247) (:id . 89))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 262) (:start . 258)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 272)\n  (:start . 263) (:id . 91))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 282)\n  (:start . 273) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s1264.6) (:did . :|9916078|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011794@unknown@formal@none@1@S@T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells.@(((:tag . "NN") (:stem . "t") (:form . "T") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1265.1) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011795@unknown@formal@none@1@S@The repetitive activation of T cells (priming) enhances the expression of many cytokines, such as IL-4, but not others, such as IL-2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "repetitive") (:form . "repetitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 118)\n  (:start . 112) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 67))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 132) (:start . 128)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1265.2.1) (:span 108 111)))\n (:nscopes ((:id . :x1265.2.1) (:span 108 132)))\n (:identifiers (:sid . :s1265.2) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011796@unknown@formal@none@1@S@Molecular mechanisms underlying selective expression of cytokines by T cells remain poorly understood.@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 41)\n  (:start . 32) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 52)\n  (:start . 42) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 65)\n  (:start . 56) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 49))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 70) (:start . 69)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 83)\n  (:start . 77) (:id . 52))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 90)\n  (:start . 84) (:id . 53))\n ((:tag . "VBN") (:stem . "understand") (:form . "understood") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1265.3) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011797@unknown@formal@none@1@S@Here we show that priming of CD4 T cells selectively enhances IL-4 expression relative to IL-2 expression by a transcriptional mechanism involving nuclear factor of activated T cells (NFAT) proteins.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "RB") (:stem . "selectively") (:form . "selectively") (:end . 52)\n  (:start . 41) (:id . 51))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "il-2") (:form . "IL-2") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 126) (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 174)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 176) (:start . 175)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 198)\n  (:start . 190) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1265.4) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011798@unknown@formal@none@1@S@As detected by in vivo footprinting, priming markedly increases the activation-dependent engagement of the P0 and P1 NFAT-binding elements of the IL-4 promoter.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "footprinting") (:form . "footprinting") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "priming") (:form . "priming") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "activation-dependent")\n  (:form . "activation-dependent") (:end . 88) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "engagement") (:form . "engagement") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "p0") (:form . "P0") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "p1") (:form . "P1") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nfat-binding") (:form . "NFAT-binding") (:end . 129)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 138)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 159)\n  (:start . 151) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1265.5) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011800@unknown@formal@none@1@S@Activated primed CD4 T cells contain more NFAT1 and support greater NFAT-directed transcription than unprimed CD4 T cells, while activator protein 1 binding and activator protein 1-mediated transcription by both cell types is similar.@(((:tag . "VBN") (:stem . "activate") (:form . "Activated") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 16) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "nfat-directed") (:form . "NFAT-directed")\n  (:end . 81) (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unprimed") (:form . "unprimed") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "activator") (:form . "activator") (:end . 170)\n  (:start . 161) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . "JJ") (:stem . "1-mediated") (:form . "1-mediated") (:end . 189)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 203) (:start . 190) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 211) (:start . 207)\n  (:id . 72))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 222)\n  (:start . 217) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 225) (:start . 223)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 233)\n  (:start . 226) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s1265.7) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011801@unknown@formal@none@1@S@Increased expression of wild-type NFAT1 substantially increases IL-4 promoter activity in unprimed CD4 T cells, suggesting NFAT1 may be limiting for IL-4 gene expression in this cell type.@(((:tag . "VBN") (:stem . "increase") (:form . "Increased") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 39) (:start . 34)\n  (:id . 46))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 53) (:start . 40) (:id . 47))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 63)\n  (:start . 54) (:id . 48))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 68) (:start . 64)\n  (:id . 49))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 86)\n  (:start . 78) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unprimed") (:form . "unprimed") (:end . 98)\n  (:start . 90) (:id . 53))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 102) (:start . 99)\n  (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 104) (:start . 103)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 110)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 122)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 128)\n  (:start . 123) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 153) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 169)\n  (:start . 159) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1265.8.1) (:span 129 132))\n  ((:id . :x1265.8.2) (:span 112 122)))\n (:hscopes ((:id . :x1265.8.1) (:span 129 187))\n  ((:id . :x1265.8.2) (:span 112 187)))\n (:identifiers (:sid . :s1265.8) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011802@unknown@formal@none@1@S@Furthermore, a truncated form of NFAT1 acts as a dominant-negative, reducing IL-4 promoter activity in primed CD4 T cells and confirming the importance of endogenous NFAT to increased IL-4 gene expression by effector T cells.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "nfat1") (:form . "NFAT1") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dominant-negative") (:form . "dominant-negative")\n  (:end . 66) (:start . 49) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "reduce") (:form . "reducing") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "confirm") (:form . "confirming") (:end . 136)\n  (:start . 126) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 151)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 165)\n  (:start . 155) (:id . 68))\n ((:tag . "NN") (:stem . "nfat") (:form . "NFAT") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 183)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 204)\n  (:start . 194) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 75))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 218) (:start . 217)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 224)\n  (:start . 219) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1265.9) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011803@unknown@formal@none@1@S@NFAT1 appears to be the major NFAT family member responsible for the initial increased expression of IL-4 by primed CD4 T cells.@(((:tag . "NNP") (:stem . "NFAT1") (:form . "NFAT1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NFAT") (:form . "NFAT") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "prim") (:form . "primed") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "cd4") (:form . "CD4") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1265.10.1) (:span 6 13)))\n (:hscopes ((:id . :x1265.10.1) (:span 0 127)))\n (:identifiers (:sid . :s1265.10) (:did . :|9916709|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011804@unknown@formal@none@1@S@Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome.@(((:tag . "NNP") (:stem . "Inhibition") (:form . "Inhibition") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "26s") (:form . "26S") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 80)\n  (:start . 70) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1266.1) (:did . :|9919536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011805@unknown@formal@none@1@S@It is becoming increasingly apparent that NF-kappa B plays a critical role in regulating the inflammatory response.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "become") (:form . "becoming") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "RB") (:stem . "increasingly") (:form . "increasingly") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 105)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1266.2) (:did . :|9919536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011806@unknown@formal@none@1@S@Data obtained from studies in our laboratories demonstrate that the proteasome plays an important role in the inflammatory cascade by regulating the activation of NF-kappa B.@(((:tag . "NNP") (:stem . "Datum") (:form . "Data") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "laboratory") (:form . "laboratories") (:end . 46)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 122)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 171)\n  (:start . 163) (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1266.3) (:did . :|9919536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011807@unknown@formal@none@1@S@Indeed, the availability of selective and orally active proteasome inhibitors should prove useful in delineating the roles of the proteasome and NF-kappa B in other pathophysiological conditions such as cancer and heart disease.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "selective") (:form . "selective") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "orally") (:form . "orally") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "delineate") (:form . "delineating") (:end . 112)\n  (:start . 101) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 122)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proteasome") (:form . "proteasome") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappa") (:form . "NF-kappa") (:end . 153)\n  (:start . 145) (:id . 64))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 155) (:start . 154)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "JJ") (:stem . "pathophysiological") (:form . "pathophysiological")\n  (:end . 183) (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 194)\n  (:start . 184) (:id . 69))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 202) (:start . 200)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cancer") (:form . "cancer") (:end . 209)\n  (:start . 203) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 73))\n ((:tag . "NN") (:stem . "heart") (:form . "heart") (:end . 219)\n  (:start . 214) (:id . 74))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 227)\n  (:start . 220) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1266.4.1) (:span 78 84)))\n (:hscopes ((:id . :x1266.4.1) (:span 78 227)))\n (:identifiers (:sid . :s1266.4) (:did . :|9919536|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011808@unknown@formal@none@1@S@Comparison of HTLV-I basal transcription and expression of CREB/ATF-1/CREM family members in peripheral blood mononuclear cells and Jurkat T cells.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 40) (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CREB/ATF-1/CREM") (:form . "CREB/ATF-1/CREM")\n  (:end . 74) (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 81)\n  (:start . 75) (:id . 51))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 103)\n  (:start . 93) (:id . 54))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 109)\n  (:start . 104) (:id . 55))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 121)\n  (:start . 110) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 127)\n  (:start . 122) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 138)\n  (:start . 132) (:id . 59))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 140) (:start . 139)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1267.1) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011810@unknown@formal@none@1@S@Following integration into the host cell genome, HTLV-I replication is regulated by both host and viral mechanisms that control transcription.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "control") (:form . "control") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 141) (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1267.3) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011811@unknown@formal@none@1@S@Low levels of viral transcription (basal transcription) occur before expression of the virally encoded Tax protein (Tax-mediated transcription).@(((:tag . "JJ") (:stem . "low") (:form . "Low") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 54) (:start . 41) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "virally") (:form . "virally") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "NNP") (:stem . "Tax") (:form . "Tax") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tax-mediated") (:form . "Tax-mediated") (:end . 128)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 142) (:start . 129) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1267.4) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011812@unknown@formal@none@1@S@Members of the cyclic adenosine monophosphate (cAMP) response element binding (CREB)/activating transcription factor 1 (ATF-1) family of transcription factors bind three 21-bp repeats (Tax-responsive element-1, or TRE-1) within the viral promoter and are important for basal and Tax-mediated transcription.@(((:tag . "NNS") (:stem . "member") (:form . "Members") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "monophosphate") (:form . "monophosphate")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . 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"the") (:end . 231) (:start . 228)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "viral") (:form . "viral") (:end . 237)\n  (:start . 232) (:id . 79))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 246)\n  (:start . 238) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 250) (:start . 247)\n  (:id . 81))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 254) (:start . 251)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 264)\n  (:start . 255) (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 268) (:start . 265)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 274)\n  (:start . 269) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 278) (:start . 275)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "tax-mediated") (:form . "Tax-mediated") (:end . 291)\n  (:start . 279) (:id . 87))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 305) (:start . 292) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s1267.5) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011813@unknown@formal@none@1@S@Using mitogen stimulated and quiescent peripheral blood mononuclear cells (PBMC) and Jurkat cells, we compared differences in basal transcription and amounts and binding of transcription factors with TRE-1.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mitogen") (:form . "mitogen") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "stimulate") (:form . "stimulated") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "quiescent") (:form . "quiescent") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "JJ") (:stem . "peripheral") (:form . "peripheral") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 55) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mononuclear") (:form . "mononuclear") (:end . 67)\n  (:start . 56) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 91)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 145) (:start . 132) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 157)\n  (:start . 150) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 169)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 186) (:start . 173) (:id . 69))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 194)\n  (:start . 187) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tre-1") (:form . "TRE-1") (:end . 205)\n  (:start . 200) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1267.6) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011814@unknown@formal@none@1@S@We demonstrate that amounts of transcriptionally active phosphorylated CREB protein (P-CREB) differ between activated PBMC and Jurkat cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 48) (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 55)\n  (:start . 49) (:id . 48))\n ((:tag . "VBN") (:stem . "phosphorylate") (:form . "phosphorylated")\n  (:end . 70) (:start . 56) (:id . 49))\n ((:tag . "NN") (:stem . "creb") (:form . "CREB") (:end . 75) (:start . 71)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "P-CREB") (:form . "P-CREB") (:end . 91)\n  (:start . 85) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 117)\n  (:start . 108) (:id . 57))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 133)\n  (:start . 127) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1267.7) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011815@unknown@formal@none@1@S@Following stimulation, P-CREB levels remain elevated in PBMC for up to 24 hours whereas CREB is dephosphorylated in Jurkat cells within 4 hours following stimulation.@(((:tag . "VBG") (:stem . "follow") (:form . "Following") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "P-CREB") (:form . "P-CREB") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NNP") (:stem . "CREB") (:form . "CREB") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "dephosphorylate") (:form . "dephosphorylated")\n  (:end . 112) (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 137) (:start . 136)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "stimulation") (:form . "stimulation") (:end . 165)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1267.8) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011816@unknown@formal@none@1@S@The differences in P-CREB levels between PBMC and Jurkat cells were directly correlated with basal transcription of HTLV-I in the two cell types.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "P-CREB") (:form . "P-CREB") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 112) (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 122)\n  (:start . 116) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1267.9) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011817@unknown@formal@none@1@S@Using electrophoretic mobility shift assays, we determined that the pattern of band migration differed between the two cell types.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 21) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 30)\n  (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 36) (:start . 31)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 43)\n  (:start . 37) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "determine") (:form . "determined") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "band") (:form . "band") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "migration") (:form . "migration") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "VBD") (:stem . "differ") (:form . "differed") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 110)\n  (:start . 103) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1267.10) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011818@unknown@formal@none@1@S@These data demonstrate that PBMC differentially regulate basal HTLV-I transcription compared with Jurkat T cells, and this differential regulation is due, in part to differential phosphorylation and binding of CREB/ATF-1 to TRE-1 in the HTLV-I promoter.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PBMC") (:form . "PBMC") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "differentially") (:form . "differentially")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 69)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 92)\n  (:start . 84) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 104)\n  (:start . 98) (:id . 54))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 106) (:start . 105)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 135)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 146)\n  (:start . 136) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 162) (:start . 158)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 178)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "phosphorylation") (:form . "phosphorylation")\n  (:end . 194) (:start . 179) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 206)\n  (:start . 199) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "NN") (:stem . "creb/atf-1") (:form . "CREB/ATF-1") (:end . 220)\n  (:start . 210) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 223) (:start . 221)\n  (:id . 74))\n ((:tag . "NN") (:stem . "tre-1") (:form . "TRE-1") (:end . 229)\n  (:start . 224) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 232) (:start . 230)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 236) (:start . 233)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "HTLV-I") (:form . "HTLV-I") (:end . 243)\n  (:start . 237) (:id . 78))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 252)\n  (:start . 244) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1267.11) (:did . :|9928723|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011820@unknown@formal@none@1@S@NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 65)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1268.1) (:did . :|9933632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011821@unknown@formal@none@1@S@During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis before being cleared by phagocytes in a non-phlogistic manner.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "beneficial") (:form . "beneficial") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 30)\n  (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 45))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "tissue-damaging") (:form . "tissue-damaging")\n  (:end . 59) (:start . 44) (:id . 47))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 72)\n  (:start . 60) (:id . 48))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 80)\n  (:start . 73) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 90)\n  (:start . 81) (:id . 50))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 97)\n  (:start . 91) (:id . 51))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 103) (:start . 98)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "clear") (:form . "cleared") (:end . 111)\n  (:start . 104) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "phagocyte") (:form . "phagocytes") (:end . 125)\n  (:start . 115) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "non-phlogistic") (:form . "non-phlogistic")\n  (:end . 145) (:start . 131) (:id . 58))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 152)\n  (:start . 146) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x1268.2.1) (:span 32 43)))\n (:hscopes ((:id . :x1268.2.1) (:span 32 59)))\n (:identifiers (:sid . :s1268.2) (:did . :|9933632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011822@unknown@formal@none@1@S@Here we show that the rate of constitutive apoptosis in human neutrophils and eosinophils is greatly accelerated in both a rapid and concentration-dependent manner by the fungal metabolite gliotoxin, but not by its inactive analog methylthiogliotoxin.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 42)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "eosinophil") (:form . "eosinophils") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "VBN") (:stem . "accelerate") (:form . "accelerated") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "concentration-dependent")\n  (:form . "concentration-dependent") (:end . 156) (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "fungal") (:form . "fungal") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 188)\n  (:start . 178) (:id . 69))\n ((:tag . "NN") (:stem . "gliotoxin") (:form . "gliotoxin") (:end . 198)\n  (:start . 189) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 203) (:start . 200)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 207) (:start . 204)\n  (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 210) (:start . 208)\n  (:id . 74))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 214) (:start . 211)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 223)\n  (:start . 215) (:id . 76))\n ((:tag . "NN") (:stem . "analog") (:form . "analog") (:end . 230)\n  (:start . 224) (:id . 77))\n ((:tag . "NN") (:stem . "methylthiogliotoxin")\n  (:form . "methylthiogliotoxin") (:end . 250) (:start . 231) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x1268.3.1) (:span 204 207)))\n (:nscopes ((:id . :x1268.3.1) (:span 204 250)))\n (:identifiers (:sid . :s1268.3) (:did . :|9933632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011823@unknown@formal@none@1@S@This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "induction") (:form . "induction") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "abolish") (:form . "abolished") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . 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"mimicked") (:end . 163)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 173) (:start . 169)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "permeable") (:form . "permeable") (:end . 183)\n  (:start . 174) (:id . 72))\n ((:tag . "JJ") (:stem . "inhibitory") (:form . "inhibitory") (:end . 194)\n  (:start . 184) (:id . 73))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 202)\n  (:start . 195) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 215)\n  (:start . 206) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "SN-50") (:form . 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5011824@unknown@formal@none@1@S@Gliotoxin also augmented dramatically the early (2-6 h) pro-apoptotic effects of tumor necrosis factor-alpha (TNF-alpha) in neutrophils and unmasked the ability of TNF-alpha to induce eosinophil apoptosis.@(((:tag . "NNP") (:stem . "Gliotoxin") (:form . "Gliotoxin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "CD") (:stem . "2-6") (:form . "2-6") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "factor-alpha") (:form . "factor-alpha") (:end . 108)\n  (:start . 96) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 135)\n  (:start . 124) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "unmask") (:form . "unmasked") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 160)\n  (:start . 153) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 173)\n  (:start . 164) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 69))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "NN") (:stem . "eosinophil") (:form . "eosinophil") (:end . 194)\n  (:start . 184) (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 204)\n  (:start . 195) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1268.5) (:did . :|9933632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011825@unknown@formal@none@1@S@In neutrophils, TNF-alpha caused a gliotoxin-inhibitable activation of an inducible form of NF-kappaB, a response that may underlie the ability of TNF-alpha to delay apoptosis at later times (12-24 h) and limit its early killing effect.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "neutrophil") (:form . "neutrophils") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "VBD") (:stem . "cause") (:form . "caused") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "gliotoxin-inhibitable")\n  (:form . "gliotoxin-inhibitable") (:end . 56) (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 67)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inducible") (:form . "inducible") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 88) (:start . 84)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 101)\n  (:start . 92) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "VB") (:stem . "underlie") (:form . "underlie") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 143)\n  (:start . 136) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TNF-alpha") (:form . "TNF-alpha") (:end . 156)\n  (:start . 147) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "VB") (:stem . "delay") (:form . "delay") (:end . 165)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 175)\n  (:start . 166) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 184)\n  (:start . 179) (:id . 70))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 192) (:start . 191)\n  (:id . 72))\n ((:tag . "CD") (:stem . "12-24") (:form . "12-24") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "NN") (:stem . "h") (:form . "h") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "VB") (:stem . "limit") (:form . "limit") (:end . 210)\n  (:start . 205) (:id . 77))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 214) (:start . 211)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 220)\n  (:start . 215) (:id . 79))\n ((:tag . "NN") (:stem . "killing") (:form . "killing") (:end . 228)\n  (:start . 221) (:id . 80))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 235)\n  (:start . 229) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x1268.6.1) (:span 119 122)))\n (:hscopes ((:id . :x1268.6.1) (:span 119 235)))\n (:identifiers (:sid . :s1268.6) (:did . :|9933632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011826@unknown@formal@none@1@S@Furthermore, cycloheximide displayed a similar capacity to enhance TNF-alpha induced neutrophil apoptosis even at time points when cycloheximide alone had no pro-apoptotic effect, suggesting that NF-kappaB may regulate the production of protein(s) which protect neutrophils from the cytotoxic effects of TNF-alpha.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cycloheximide") (:form . "cycloheximide")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "display") (:form . "displayed") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NN") (:stem . "capacity") (:form . 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5011827@unknown@formal@none@1@S@These data shed light on the biochemical and molecular mechanisms regulating human granulocyte apoptosis and, in particular, indicate that the transcription factor NF-kappaB plays a crucial role in regulating the physiological cell death pathway in granulocytes.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "shed") (:form . "shed") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "granulocyte") (:form . "granulocyte") (:end . 94)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 156) (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 173)\n  (:start . 164) (:id . 66))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 179)\n  (:start . 174) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 189)\n  (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 194) (:start . 190)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 208)\n  (:start . 198) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "physiological") (:form . "physiological")\n  (:end . 226) (:start . 213) (:id . 74))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 231) (:start . 227)\n  (:id . 75))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 237)\n  (:start . 232) (:id . 76))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 245)\n  (:start . 238) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 248) (:start . 246)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "granulocyte") (:form . "granulocytes") (:end . 261)\n  (:start . 249) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x1268.8.1) (:span 125 138)))\n (:hscopes ((:id . :x1268.8.1) (:span 125 261)))\n (:identifiers (:sid . :s1268.8) (:did . :|9933632|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011828@unknown@formal@none@1@S@Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB.@(((:tag . "NNP") (:stem . "Lactobacilli") (:form . "Lactobacilli") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "vaginal") (:form . "vaginal") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 79) (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 113)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 123)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1269.1) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011830@unknown@formal@none@1@S@Activation of the LTR in Jurkat cells was strongly enhanced by vanadate and inhibited by catalase, implicating H2O2.@(((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Jurkat") (:form . "Jurkat") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "VBN") (:stem . "enhance") (:form . "enhanced") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "vanadate") (:form . "vanadate") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "implicate") (:form . "implicating") (:end . 110)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "h2o2") (:form . "H2O2") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1269.3) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011831@unknown@formal@none@1@S@In contrast, activation in THP-1 cells occurred in the absence of vanadate and was unaffected by catalase.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "vanadate") (:form . "vanadate") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unaffected") (:form . "unaffected") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "catalase") (:form . "catalase") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1269.4.1) (:span 55 62)))\n (:nscopes ((:id . :x1269.4.1) (:span 55 74)))\n (:identifiers (:sid . :s1269.4) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011832@unknown@formal@none@1@S@The active material partitioned into the phenol layer on hot aqueous phenol extraction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "material") (:form . "material") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "partition") (:form . "partitioned") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "phenol") (:form . "phenol") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "layer") (:form . "layer") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hot") (:form . "hot") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "aqueous") (:form . "aqueous") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "phenol") (:form . "phenol") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "extraction") (:form . "extraction") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1269.5) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011833@unknown@formal@none@1@S@Lactobacilli also increased tumor necrosis factor-alphaand interleukin-1betaproduction and activated NF-kappaB in THP-1 cells and increased tumor necrosis factor-alphaproduction by human monocytes.@(((:tag . "NNP") (:stem . "Lactobacilli") (:form . "Lactobacilli") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "factor-alphaand") (:form . "factor-alphaand")\n  (:end . 58) (:start . 43) (:id . 47))\n ((:tag . "NN") (:stem . "interleukin-1betaproduction")\n  (:form . "interleukin-1betaproduction") (:end . 86) (:start . 59)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "activate") (:form . "activated") (:end . 100)\n  (:start . 91) (:id . 50))\n ((:tag . "NN") (:stem . "nf-kappab") (:form . "NF-kappaB") (:end . 110)\n  (:start . 101) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 52))\n ((:tag . "NN") (:stem . "thp-1") (:form . "THP-1") (:end . 119)\n  (:start . 114) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 139)\n  (:start . 130) (:id . 56))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 145)\n  (:start . 140) (:id . 57))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 154)\n  (:start . 146) (:id . 58))\n ((:tag . "NN") (:stem . "factor-alphaproduction")\n  (:form . "factor-alphaproduction") (:end . 177) (:start . 155) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 186)\n  (:start . 181) (:id . 61))\n ((:tag . "NNS") (:stem . "monocyte") (:form . "monocytes") (:end . 196)\n  (:start . 187) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1269.6) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011834@unknown@formal@none@1@S@Human vaginal fluid specimens had comparable properties, which correlated with their bacterial content.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "vaginal") (:form . "vaginal") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "specimen") (:form . "specimens") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 73)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 84)\n  (:start . 79) (:id . 53))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1269.7) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011835@unknown@formal@none@1@S@These findings suggest the presence in vaginal fluid of agent(s) derived from indigenous bacteria that can activate the HIV-1 LTR, cytokine production, and NF-kappaB in cells of macrophage lineage, with possible influence on vaginal physiology and host defense.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "vaginal") (:form . "vaginal") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "fluid") (:form . "fluid") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "agent(s)") (:form . "agent(s)") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "indigenous") (:form . "indigenous") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 115)\n  (:start . 107) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 165)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 174)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 70))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 188)\n  (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 196)\n  (:start . 189) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 202) (:start . 198)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 211)\n  (:start . 203) (:id . 75))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 221)\n  (:start . 212) (:id . 76))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 224) (:start . 222)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "vaginal") (:form . "vaginal") (:end . 232)\n  (:start . 225) (:id . 78))\n ((:tag . "NN") (:stem . "physiology") (:form . "physiology") (:end . 243)\n  (:start . 233) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 247) (:start . 244)\n  (:id . 80))\n ((:tag . "NN") (:stem . "host") (:form . "host") (:end . 252) (:start . 248)\n  (:id . 81))\n ((:tag . "NN") (:stem . "defense") (:form . "defense") (:end . 260)\n  (:start . 253) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1269.8.1) (:span 203 211))\n  ((:id . :x1269.8.2) (:span 15 22)))\n (:hscopes ((:id . :x1269.8.1) (:span 203 260))\n  ((:id . :x1269.8.2) (:span 15 260)))\n (:identifiers (:sid . :s1269.8) (:did . :|9952372|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011836@unknown@formal@none@1@S@High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.@(((:tag . "JJ") (:stem . "high-level") (:form . "High-level") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 48) (:start . 32) (:id . 46))\n ((:tag . "NN") (:stem . "virus") (:form . "virus") (:end . 54) (:start . 49)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 87)\n  (:start . 78) (:id . 51))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 98)\n  (:start . 88) (:id . 52))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 106)\n  (:start . 99) (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 118)\n  (:start . 107) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 130)\n  (:start . 124) (:id . 56))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 141)\n  (:start . 131) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 147)\n  (:start . 142) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1270.1) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011837@unknown@formal@none@1@S@We have previously demonstrated that interaction of infected thymocytes with autologous thymic epithelial cells (TEC) is a prerequisite for a high level of human immunodeficiency virus type 1 (HIV-1) replication in thymocytes (M.Rothe, L.Chene, M.Nugeyre, F.Barre-Sinoussi, and N.Israel, J.Virol.72:5852-5861, 1998).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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"N.Israel") (:end . 286)\n  (:start . 278) (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 287) (:start . 286)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "J.Virol.72:5852-5861")\n  (:form . "J.Virol.72:5852-5861") (:end . 308) (:start . 288) (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 309) (:start . 308)\n  (:id . 91))\n ((:tag . "CD") (:stem . "1998") (:form . "1998") (:end . 314) (:start . 310)\n  (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 315) (:start . 314)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s1270.2) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011838@unknown@formal@none@1@S@We report here that this activation of HIV replication takes place at the transcriptional level through activation of the Rel/NF-kappaB transcription factors.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 54)\n  (:start . 43) (:id . 50))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 89) (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Rel/NF-kappaB") (:form . "Rel/NF-kappaB")\n  (:end . 135) (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 149) (:start . 136) (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 157)\n  (:start . 150) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1270.3) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011840@unknown@formal@none@1@S@We provide evidence that several NF-kappaB complexes are constitutively found in the nuclei of thymocytes either freshly isolated from the thymus or maintained in coculture with autologous or heterologous TEC.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 71) (:start . 57) (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 77) (:start . 72)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 112)\n  (:start . 106) (:id . 57))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "thymus") (:form . "thymus") (:end . 145)\n  (:start . 139) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "NN") (:stem . "coculture") (:form . "coculture") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "autologous") (:form . "autologous") (:end . 188)\n  (:start . 178) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 191) (:start . 189)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 204)\n  (:start . 192) (:id . 70))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 208) (:start . 205)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s1270.5) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011841@unknown@formal@none@1@S@The prevalent complex is the heterodimer p50-p65.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "prevalent") (:form . "prevalent") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "heterodimer") (:form . "heterodimer") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "p50-p65") (:form . "p50-p65") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1270.6) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011842@unknown@formal@none@1@S@NF-kappaB activity is tightly correlated with the transcriptional activity of a long terminal repeat (LTR) of HIV-1 transfected in thymocytes.@(((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 65) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 74)\n  (:start . 66) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 93)\n  (:start . 85) (:id . 54))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "HIV-1") (:form . "HIV-1") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 127)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1270.7) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011843@unknown@formal@none@1@S@The cotransfection of this LTR with a mutated IkappaBalpha molecule formally demonstrates that LTR transactivation is regulated by members of the Rel/NF-kappaB family in thymocytes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cotransfection") (:form . "cotransfection")\n  (:end . 18) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "IkappaBalpha") (:form . "IkappaBalpha") (:end . 58)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "RB") (:stem . "formally") (:form . "formally") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 89)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 114) (:start . 99) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 127)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Rel/NF-kappaB") (:form . "Rel/NF-kappaB")\n  (:end . 159) (:start . 146) (:id . 63))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 166)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 180)\n  (:start . 170) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1270.8) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011844@unknown@formal@none@1@S@We also showed that tumor necrosis factor (TNF) and to a lesser extent interleukin-1 (IL-1), secreted within the coculture, induce NF-kappaB activity and a correlative LTR transactivation.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "necrosis") (:form . "necrosis") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "less") (:form . "lesser") (:end . 63) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 70)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "interleukin-1") (:form . "interleukin-1")\n  (:end . 84) (:start . 71) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 101)\n  (:start . 93) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 108)\n  (:start . 102) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 64))\n ((:tag . "NN") (:stem . "coculture") (:form . "coculture") (:end . 122)\n  (:start . 113) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "induce") (:form . "induce") (:end . 130)\n  (:start . 124) (:id . 67))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 140)\n  (:start . 131) (:id . 68))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 149)\n  (:start . 141) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "correlative") (:form . "correlative") (:end . 167)\n  (:start . 156) (:id . 72))\n ((:tag . "NN") (:stem . "ltr") (:form . "LTR") (:end . 171) (:start . 168)\n  (:id . 73))\n ((:tag . "NN") (:stem . "transactivation") (:form . "transactivation")\n  (:end . 187) (:start . 172) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1270.9) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011845@unknown@formal@none@1@S@However IL-7, a crucial factor for thymopoiesis that is secreted mainly by TEC, is a necessary cofactor for NF-kappaB activation elicited by TNF or IL-1.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "thymopoiesis") (:form . "thymopoiesis") (:end . 47)\n  (:start . 35) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TEC") (:form . "TEC") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 94)\n  (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "cofactor") (:form . "cofactor") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 117)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . "VBN") (:stem . "elicit") (:form . "elicited") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1270.10) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011846@unknown@formal@none@1@S@Together, these data indicate that NF-kappaB activation, required for a high level of HIV replication in thymocytes, is regulated in a specific manner in the thymic microenvironment which provides the necessary cytokines: TNF, IL-1, and IL-7.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NF-kappaB") (:form . "NF-kappaB") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HIV") (:form . "HIV") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "thymocyte") (:form . "thymocytes") (:end . 115)\n  (:start . 105) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 143)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 150)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "thymic") (:form . "thymic") (:end . 164)\n  (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "microenvironment") (:form . "microenvironment")\n  (:end . 181) (:start . 165) (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 196)\n  (:start . 188) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 210)\n  (:start . 201) (:id . 75))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 220)\n  (:start . 211) (:id . 76))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 221) (:start . 220)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 225) (:start . 222)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "IL-1") (:form . "IL-1") (:end . 231) (:start . 227)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 232) (:start . 231)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "IL-7") (:form . "IL-7") (:end . 241) (:start . 237)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x1270.11.1) (:span 21 34)))\n (:hscopes ((:id . :x1270.11.1) (:span 21 241)))\n (:identifiers (:sid . :s1270.11) (:did . :|9971788|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011847@unknown@formal@none@1@S@Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1.@(((:tag . "NN") (:stem . "cross-linking") (:form . "Cross-linking")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "up-regulate") (:form . "up-regulates") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 70)\n  (:start . 64) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1271.1) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011848@unknown@formal@none@1@S@CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.@(((:tag . "NNP") (:stem . "CD44") (:form . "CD44") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "hyaluronic") (:form . "hyaluronic") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "homing") (:form . "homing") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1271.2) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011850@unknown@formal@none@1@S@In this study, we propose a novel function for CD44.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 42)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1271.4) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011851@unknown@formal@none@1@S@Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rheumatoid") (:form . "rheumatoid") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "arthritis") (:form . "arthritis") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "patient") (:form . "patients") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 77)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cross-linking") (:form . "cross-linking")\n  (:end . 101) (:start . 88) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hyaluronan") (:form . "hyaluronan") (:end . 127)\n  (:start . 117) (:id . 61))\n ((:tag . "VBD") (:stem . "augment") (:form . "augmented") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 65))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 172)\n  (:start . 160) (:id . 66))\n ((:tag . "JJ") (:stem . "vcam-1-mediated") (:form . "VCAM-1-mediated")\n  (:end . 188) (:start . 173) (:id . 67))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 202)\n  (:start . 194) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1271.5) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011852@unknown@formal@none@1@S@Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.@(((:tag . "RB") (:stem . "briefly") (:form . "Briefly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "LS") (:stem . "1") (:form . 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5011853@unknown@formal@none@1@S@These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "matrix") (:form . "matrices") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "hyaluronic") (:form . "hyaluronic") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "cd44") (:form . "CD44") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "VB") (:stem . "up-regulate") (:form . "up-regulate") (:end . 128)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "vcam-1-mediated") (:form . "VCAM-1-mediated")\n  (:end . 166) (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 175)\n  (:start . 167) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 180) (:start . 179)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 199)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 207) (:start . 203)\n  (:id . 74))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 213)\n  (:start . 208) (:id . 75))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 224)\n  (:start . 214) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 227) (:start . 225)\n  (:id . 77))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 229) (:start . 228)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 235)\n  (:start . 230) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "synovial") (:form . "synovial") (:end . 248)\n  (:start . 240) (:id . 81))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 254)\n  (:start . 249) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 257) (:start . 255)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 260) (:start . 258)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "synovitis") (:form . "synovitis") (:end . 270)\n  (:start . 261) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x1271.7.1) (:span 194 199))\n  ((:id . :x1271.7.2) (:span 14 27)))\n (:hscopes ((:id . :x1271.7.1) (:span 194 270))\n  ((:id . :x1271.7.2) (:span 14 270)))\n (:identifiers (:sid . :s1271.7) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011854@unknown@formal@none@1@S@We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cross-talking") (:form . "cross-talking")\n  (:end . 44) (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 78)\n  (:start . 69) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pathogenesis") (:form . "pathogenesis") (:end . 114)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inflammation") (:form . "inflammation") (:end . 130)\n  (:start . 118) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 141)\n  (:start . 132) (:id . 61))\n ((:tag . "NNP") (:stem . "RA") (:form . "RA") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synovitis") (:form . "synovitis") (:end . 154)\n  (:start . 145) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x1271.8.1) (:span 79 82))\n  ((:id . :x1271.8.2) (:span 13 20)))\n (:hscopes ((:id . :x1271.8.1) (:span 79 154))\n  ((:id . :x1271.8.2) (:span 13 154)))\n (:identifiers (:sid . :s1271.8) (:did . :|9973520|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011855@unknown@formal@none@1@S@Oleic acid inhibits endothelial activation : A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet.@(((:tag . "JJ") (:stem . "oleic") (:form . "Oleic") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "inhibits") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 44) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 62)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "antiatherogenic") (:form . "antiatherogenic")\n  (:end . 78) (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 88)\n  (:start . 79) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nutritional") (:form . "nutritional") (:end . 105)\n  (:start . 94) (:id . 55))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 115)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mediterranean") (:form . "mediterranean")\n  (:end . 136) (:start . 123) (:id . 59))\n ((:tag . "NN") (:stem . "diet") (:form . "diet") (:end . 141) (:start . 137)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1272.1) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011856@unknown@formal@none@1@S@Because oleic acid is implicated in the antiatherogenic effects attributed to the Mediterranean diet, we investigated whether this fatty acid can modulate endothelial activation, ie, the concerted expression of gene products involved in leukocyte recruitment and early atherogenesis.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "oleic") (:form . "oleic") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "antiatherogenic") (:form . "antiatherogenic")\n  (:end . 55) (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "mediterranean") (:form . "Mediterranean")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "diet") (:form . "diet") (:end . 100) (:start . 96)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "VB") (:stem . "modulate") (:form . "modulate") (:end . 154)\n  (:start . 146) (:id . 64))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 166)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 177)\n  (:start . 167) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "FW") (:stem . "ie") (:form . "ie") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "concerted") (:form . "concerted") (:end . 196)\n  (:start . 187) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 207)\n  (:start . 197) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 210) (:start . 208)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 215) (:start . 211)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 224)\n  (:start . 216) (:id . 75))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 233)\n  (:start . 225) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 77))\n ((:tag . "NN") (:stem . "leukocyte") (:form . "leukocyte") (:end . 246)\n  (:start . 237) (:id . 78))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 258)\n  (:start . 247) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 262) (:start . 259)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 268)\n  (:start . 263) (:id . 81))\n ((:tag . "NN") (:stem . "atherogenesis") (:form . "atherogenesis")\n  (:end . 282) (:start . 269) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x1272.2.1) (:span 118 125)))\n (:hscopes ((:id . :x1272.2.1) (:span 118 282)))\n (:identifiers (:sid . :s1272.2) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011857@unknown@formal@none@1@S@We incubated sodium oleate with human umbilical vein endothelial cells for 0 to 72 hours, followed by coincubation of oleate with human recombinant tumor necrosis factor, interleukin (IL)-1alpha, IL-1beta, IL-4, Escherichia coli lipopolysaccharide (LPS), or phorbol 12-myristate 13-acetate for a further 6 to 24 hours.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "incubate") (:form . "incubated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "sodium") (:form . "sodium") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "oleate") (:form . "oleate") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "umbilical") (:form . "umbilical") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . 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5011858@unknown@formal@none@1@S@The endothelial expression of vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and intercellular adhesion molecule-1 was monitored by cell surface enzyme immunoassays or flow cytometry, and steady-state levels of VCAM-1 mRNA were assessed by Northern blot analysis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "vascular") (:form . "vascular") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "E-selectin") (:form . "E-selectin") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intercellular") (:form . "intercellular")\n  (:end . 103) (:start . 90) (:id . 57))\n ((:tag . "NN") (:stem . "adhesion") (:form . "adhesion") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "molecule-1") (:form . "molecule-1") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "monitor") (:form . "monitored") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 153)\n  (:start . 146) (:id . 64))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "NNS") (:stem . "immunoassay") (:form . "immunoassays") (:end . 173)\n  (:start . 161) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "NN") (:stem . "flow") (:form . "flow") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cytometry") (:form . "cytometry") (:end . 191)\n  (:start . 182) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "steady-state") (:form . "steady-state") (:end . 209)\n  (:start . 197) (:id . 72))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 216)\n  (:start . 210) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "VCAM-1") (:form . "VCAM-1") (:end . 226)\n  (:start . 220) (:id . 75))\n ((:tag . "NNP") (:stem . "mRNA") (:form . "mRNA") (:end . 231) (:start . 227)\n  (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 236) (:start . 232)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 245)\n  (:start . 237) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 248) (:start . 246)\n  (:id . 79))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 257)\n  (:start . 249) (:id . 80))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 262) (:start . 258)\n  (:id . 81))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 271)\n  (:start . 263) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s1272.4) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011860@unknown@formal@none@1@S@After a 72-hour incubation with oleate and a further 16-hour incubation with oleate plus 1 microg/mL LPS, VCAM-1 expression was reduced by >40% compared with control.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "72-hour") (:form . "72-hour") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oleate") (:form . "oleate") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "16-hour") (:form . "16-hour") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "incubation") (:form . "incubation") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "oleate") (:form . "oleate") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "microg/ml") (:form . "microg/mL") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "lps") (:form . "LPS") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "CD") (:stem . ">40") (:form . ">40") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 165)\n  (:start . 158) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1272.6) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011861@unknown@formal@none@1@S@Adhesion of monocytoid U937 cells to LPS-treated endothelial cells was reduced concomitantly.@(((:tag . "NNP") (:stem . "Adhesion") (:form . "Adhesion") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "monocytoid") (:form . "monocytoid") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "u937") (:form . "U937") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "lps-treated") (:form . "LPS-treated") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "RB") (:stem . "concomitantly") (:form . "concomitantly")\n  (:end . 92) (:start . 79) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1272.7) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011862@unknown@formal@none@1@S@Oleate also produced a quantitatively similar reduction of VCAM-1 mRNA levels on Northern blot analysis and inhibited nuclear factor-kappaB activation on electrophoretic mobility shift assays.@(((:tag . "NNP") (:stem . "Oleate") (:form . "Oleate") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "quantitatively") (:form . "quantitatively")\n  (:end . 37) (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "vcam-1") (:form . "VCAM-1") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "northern") (:form . "Northern") (:end . 89)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . "NN") (:stem . "factor-kappab") (:form . "factor-kappaB")\n  (:end . 139) (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 150)\n  (:start . 140) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "electrophoretic") (:form . "electrophoretic")\n  (:end . 169) (:start . 154) (:id . 63))\n ((:tag . "NN") (:stem . "mobility") (:form . "mobility") (:end . 178)\n  (:start . 170) (:id . 64))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 184)\n  (:start . 179) (:id . 65))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 191)\n  (:start . 185) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1272.8) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011863@unknown@formal@none@1@S@Incubation of endothelial cells with oleate for 72 hours decreased the relative proportions of saturated (palmitic and stearic) acids in total cell lipids and increased the proportions of oleate in total cell lipids without significantly changing the relative proportions of polyunsaturated fatty acids.@(((:tag . "NN") (:stem . "incubation") (:form . "Incubation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "endothelial") (:form . "endothelial") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "oleate") (:form . "oleate") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . 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5011864@unknown@formal@none@1@S@Although less potent than polyunsaturated fatty acids in inhibiting endothelial activation, oleic acid may contribute to the prevention of atherogenesis through selective displacement of saturated fatty acids in cell membrane phospholipids and a consequent modulation of gene expression for molecules involved in monocyte recruitment.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "potent") (:form . "potent") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "polyunsaturated") (:form . "polyunsaturated")\n  (:end . 41) (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "fatty") (:form . "fatty") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "acid") (:form . 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"fatty") (:form . "fatty") (:end . 202)\n  (:start . 197) (:id . 68))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 208)\n  (:start . 203) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 70))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 216) (:start . 212)\n  (:id . 71))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 225)\n  (:start . 217) (:id . 72))\n ((:tag . "NNS") (:stem . "phospholipid") (:form . "phospholipids")\n  (:end . 239) (:start . 226) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 245) (:start . 244)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "consequent") (:form . "consequent") (:end . 256)\n  (:start . 246) (:id . 76))\n ((:tag . "NN") (:stem . "modulation") (:form . "modulation") (:end . 267)\n  (:start . 257) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 270) (:start . 268)\n  (:id . 78))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 275) (:start . 271)\n  (:id . 79))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 286)\n  (:start . 276) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 290) (:start . 287)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "molecule") (:form . "molecules") (:end . 300)\n  (:start . 291) (:id . 82))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 309)\n  (:start . 301) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 312) (:start . 310)\n  (:id . 84))\n ((:tag . "NN") (:stem . "monocyte") (:form . "monocyte") (:end . 321)\n  (:start . 313) (:id . 85))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 333)\n  (:start . 322) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 334) (:start . 333)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x1272.10.1) (:span 103 106)))\n (:hscopes ((:id . :x1272.10.1) (:span 103 333)))\n (:identifiers (:sid . :s1272.10) (:did . :|9974401|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011865@unknown@formal@none@1@S@Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.@(((:tag . "JJ") (:stem . "functional") (:form . "Functional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Stat5") (:form . "Stat5") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Stat1") (:form . "Stat1") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IL-2-") (:form . "IL-2-") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ifngamma-mediated") (:form . "IFNgamma-mediated")\n  (:end . 81) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1273.1) (:did . :|9989503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|Title|)))@oe@15-2-2011
5011866@unknown@formal@none@1@S@Using the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "coiled-coil") (:form . "coiled-coil") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Stat5b") (:form . "Stat5b") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bait") (:form . "bait") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "two-hybrid") (:form . "two-hybrid") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "association") (:form . "association") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 148)\n  (:start . 140) (:id . 68))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 159)\n  (:start . 149) (:id . 69))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "N-Myc") (:form . "N-Myc") (:end . 180)\n  (:start . 175) (:id . 73))\n ((:tag . "NN") (:stem . "interactor") (:form . "interactor") (:end . 191)\n  (:start . 181) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x1273.2.1) (:span 132 139)))\n (:hscopes ((:id . :x1273.2.1) (:span 132 148)))\n (:identifiers (:sid . :s1273.2) (:did . :|9989503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011867@unknown@formal@none@1@S@We further show that Nmi interacts with all STATs except Stat2.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "stat") (:form . "STATs") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "stat2") (:form . "Stat2") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1273.3) (:did . :|9989503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011868@unknown@formal@none@1@S@We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "evaluate") (:form . "evaluated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "IL-2") (:form . "IL-2") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "IFNgamma") (:form . "IFNgamma") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 69)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "augment") (:form . "augments") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "stat-mediated") (:form . "STAT-mediated")\n  (:end . 101) (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NNS") (:stem . "cytokine") (:form . "cytokines") (:end . 146)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1273.4) (:did . :|9989503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5011870@unknown@formal@none@1@S@Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Nmi") (:form . "Nmi") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "VB") (:stem . "potentiate") (:form . "potentiate") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "JJ") (:stem . "stat-dependent") (:form . "STAT-dependent")\n  (:end . 74) (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "coactivator") (:form . "coactivator") (:end . 138)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "sequence-specific") (:form . "sequence-specific")\n  (:end . 215) (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 229) (:start . 216) (:id . 76))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 237)\n  (:start . 230) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1273.6.1) (:span 99 106)))\n (:hscopes ((:id . :x1273.6.1) (:span 99 237)))\n (:identifiers (:sid . :s1273.6) (:did . :|9989503|) (:did-type . :pmid)\n  (:dtype . :|Biological_abstract|) (:dpart . :|AbstractText|)))@oe@15-2-2011
5100000@unknown@formal@none@1@S@Mining prokaryotic genomes for unknown amino acids: a stop-codon-based approach@(((:tag . "VBG") (:stem . "mine") (:form . "Mining") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "stop-codon-based") (:form . "stop-codon-based")\n  (:end . 70) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 79)\n  (:start . 71) (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.1) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100001@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.2) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100002@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.3) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100003@unknown@formal@none@1@S@Selenocysteine and pyrrolysine are the 21st and 22nd amino acids, which are genetically encoded by stop codons.@(((:tag . "NNP") (:stem . "Selenocysteine") (:form . "Selenocysteine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "21st") (:form . "21st") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "22nd") (:form . "22nd") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.4) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100004@unknown@formal@none@1@S@Since a number of microbial genomes have been completely sequenced to date, it is tempting to ask whether the 23rd amino acid is left undiscovered in these genomes.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "tempt") (:form . "tempting") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "VB") (:stem . "ask") (:form . "ask") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "leave") (:form . "left") (:end . 133)\n  (:start . 129) (:id . 66))\n ((:tag . "JJ") (:stem . "undiscovered") (:form . "undiscovered") (:end . 146)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 163)\n  (:start . 156) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1.5.1) (:span 98 105)))\n (:hscopes ((:id . :x1.5.1) (:span 98 163)))\n (:identifiers (:sid . :s1.5) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100005@unknown@formal@none@1@S@Recently, a computational study addressed this question and reported that no tRNA gene for unknown amino acid was found in genome sequences available.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "address") (:form . "addressed") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 149)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1.6.1) (:span 74 76)))\n (:nscopes ((:id . :x1.6.1) (:span 74 149)))\n (:identifiers (:sid . :s1.6) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100006@unknown@formal@none@1@S@However, performance of the tRNA prediction program on an unknown tRNA family, which may have atypical sequence and structure, is unclear, thereby rendering their result inconclusive.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 146)\n  (:start . 139) (:id . 67))\n ((:tag . "VBG") (:stem . "render") (:form . "rendering") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 169)\n  (:start . 163) (:id . 70))\n ((:tag . "JJ") (:stem . "inconclusive") (:form . "inconclusive") (:end . 182)\n  (:start . 170) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x1.7.2) (:span 130 137)) ((:id . :x1.7.1) (:span 85 88)))\n (:hscopes ((:id . :x1.7.1) (:span 85 125)) ((:id . :x1.7.2) (:span 9 137)))\n (:identifiers (:sid . :s1.7) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100007@unknown@formal@none@1@S@A protein-level study will provide independent insight into the novel amino acid.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "protein-level") (:form . "protein-level")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 69) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.8) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100008@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.9) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100010@unknown@formal@none@1@S@Since our prediction method relies only on the conservation patterns of primary sequences, it also provides an opportunity to search novel selenoproteins and other readthrough proteins.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "rely") (:form . "relies") (:end . 34) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "opportunity") (:form . "opportunity") (:end . 122)\n  (:start . 111) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "VB") (:stem . "search") (:form . "search") (:end . 132)\n  (:start . 126) (:id . 62))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 153) (:start . 139) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 163)\n  (:start . 158) (:id . 66))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 175)\n  (:start . 164) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 184)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.11) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100011@unknown@formal@none@1@S@It successfully recovered many of currently known selenoproteins and pyrrolysine proteins.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "recover") (:form . "recovered") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 80)\n  (:start . 69) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.12) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100012@unknown@formal@none@1@S@However, no promising candidate for the 23rd amino acid was detected, and only one novel selenoprotein was predicted.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "promising") (:form . "promising") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 102) (:start . 89) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1.13.1) (:span 9 11)))\n (:nscopes ((:id . :x1.13.1) (:span 9 68)))\n (:identifiers (:sid . :s1.13) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100013@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.14) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100014@unknown@formal@none@1@S@Our result suggests that the unknown amino acid encoded by stop codons does not exist, or its phylogenetic distribution is rather limited, which is in agreement with the previous study on tRNA.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 106)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 119)\n  (:start . 107) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 137)\n  (:start . 130) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 160)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 178)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 184)\n  (:start . 179) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 187) (:start . 185)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "tRNA") (:form . "tRNA") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x1.15.2) (:span 87 89)) ((:id . :x1.15.3) (:span 11 19)))\n (:ncues ((:id . :x1.15.1) (:span 76 79)))\n (:hscopes ((:id . :x1.15.2) (:span 25 137))\n  ((:id . :x1.15.3) (:span 11 137)))\n (:nscopes ((:id . :x1.15.1) (:span 76 85)))\n (:identifiers (:sid . :s1.15) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100015@unknown@formal@none@1@S@The method described here can be used in future studies to explore novel readthrough events from complete genomes, which are rapidly growing.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 140)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.16) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100016@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.17) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100017@unknown@formal@none@1@S@Stop codon readthrough is a phenomenon in which the translation process does not terminate at a stop codon, and an amino acid is inserted there instead 12.@(((:tag . "NNP") (:stem . "Stop") (:form . "Stop") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "phenomenon") (:form . "phenomenon") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "terminate") (:form . "terminate") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 137)\n  (:start . 129) (:id . 66))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1.18.1) (:span 77 80)))\n (:nscopes ((:id . :x1.18.1) (:span 77 106)))\n (:identifiers (:sid . :s1.18) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100018@unknown@formal@none@1@S@In some cases, the inserted amino acid is not one of the 20 amino acids but a noncanonical one.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 59) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 65) (:start . 60)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 75) (:start . 72)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "noncanonical") (:form . "noncanonical") (:end . 90)\n  (:start . 78) (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1.19.1) (:span 42 45)))\n (:nscopes ((:id . :x1.19.1) (:span 42 71)))\n (:identifiers (:sid . :s1.19) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100020@unknown@formal@none@1@S@Because each of them have specialized tRNA genes for decoding and can be considered extensions of the standard genetic code, they are called the 21st and 22nd amino acids, respectively.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "specialize") (:form . "specialized") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "decode") (:form . "decoding") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "NNS") (:stem . "extension") (:form . "extensions") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "21st") (:form . "21st") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "22nd") (:form . "22nd") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 184)\n  (:start . 172) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s1.21) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100021@unknown@formal@none@1@S@Selenocysteine, the 21st amino acid, is encoded by stop codon UGA, and organisms that use selenocysteine have been found from all three domains of life.@(((:tag . "NNP") (:stem . "Selenocysteine") (:form . "Selenocysteine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "21st") (:form . "21st") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "UGA") (:form . "UGA") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 80)\n  (:start . 71) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 104) (:start . 90) (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1.22) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100022@unknown@formal@none@1@S@Its insertion into UGA is directed by SECIS (selenocysteine insertion sequence) elements, a stem-loop structure on the selenoprotein mRNA.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "UGA") (:form . "UGA") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "direct") (:form . "directed") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SECIS") (:form . "SECIS") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 59) (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "stem-loop") (:form . "stem-loop") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 132) (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1.23) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100023@unknown@formal@none@1@S@Along with the progress of genome sequencing projects, computational prediction methods of selenocysteine-containing proteins (selenoproteins) have been developed by several research groups 78910, and the repertoire of selenoproteins has been greatly expanded 1112.@(((:tag . "IN") (:stem . "along") (:form . "Along") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "progress") (:form . "progress") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "project") (:form . "projects") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "selenocysteine-containing")\n  (:form . "selenocysteine-containing") (:end . 116) (:start . 91) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 125)\n  (:start . 117) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 141) (:start . 127) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 147) (:start . 143)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 152) (:start . 148)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 162)\n  (:start . 153) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 165) (:start . 163)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 173)\n  (:start . 166) (:id . 64))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 182)\n  (:start . 174) (:id . 65))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 189)\n  (:start . 183) (:id . 66))\n ((:tag . "CD") (:stem . "78910") (:form . "78910") (:end . 195)\n  (:start . 190) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 70))\n ((:tag . "NN") (:stem . "repertoire") (:form . "repertoire") (:end . 215)\n  (:start . 205) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 218) (:start . 216)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 233) (:start . 219) (:id . 73))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 237) (:start . 234)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 242) (:start . 238)\n  (:id . 75))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 250)\n  (:start . 243) (:id . 76))\n ((:tag . "VBN") (:stem . "expand") (:form . "expanded") (:end . 259)\n  (:start . 251) (:id . 77))\n ((:tag . "CD") (:stem . "1112") (:form . "1112") (:end . 264) (:start . 260)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s1.24) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100024@unknown@formal@none@1@S@Pyrrolysine, the 22nd amino acid encoded by stop codon UAG, was recently discovered from a methanogenic archaea 56.@(((:tag . "NNP") (:stem . "Pyrrolysine") (:form . "Pyrrolysine") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "22nd") (:form . "22nd") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "UAG") (:form . "UAG") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "methanogenic") (:form . "methanogenic") (:end . 103)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "archaea") (:form . "archaea") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "CD") (:stem . "56") (:form . "56") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.25) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100025@unknown@formal@none@1@S@Currently, only methanogenic archaea of the order Methanosarcinales and one bacterium are considered to utilize pyrrolysine 13.@(((:tag . "RB") (:stem . "currently") (:form . "Currently") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "methanogenic") (:form . "methanogenic") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "archaea") (:form . "archaea") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Methanosarcinales") (:form . "Methanosarcinales")\n  (:end . 67) (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "bacterium") (:form . "bacterium") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "VB") (:stem . "utilize") (:form . "utilize") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 123)\n  (:start . 112) (:id . 58))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.26) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100026@unknown@formal@none@1@S@The limited phylogenetic distribution of pyrrolysine suggests that its incorporation into the genetic code of methanogen is relatively recent, and the insertion mechanism of a novel amino acid can evolve in a shorter period of time than anticipated.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 52)\n  (:start . 41) (:id . 47))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 61)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "incorporation") (:form . "incorporation")\n  (:end . 84) (:start . 71) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 89) (:start . 85)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 101)\n  (:start . 94) (:id . 54))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "methanogen") (:form . "methanogen") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 134)\n  (:start . 124) (:id . 59))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 141)\n  (:start . 135) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 160)\n  (:start . 151) (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 170)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 175) (:start . 174)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 192) (:start . 188)\n  (:id . 70))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 196) (:start . 193)\n  (:id . 71))\n ((:tag . "VB") (:stem . "evolve") (:form . "evolve") (:end . 203)\n  (:start . 197) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 208) (:start . 207)\n  (:id . 74))\n ((:tag . "JJR") (:stem . "short") (:form . "shorter") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 223)\n  (:start . 217) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 77))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 231) (:start . 227)\n  (:id . 78))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 236) (:start . 232)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "anticipate") (:form . "anticipated") (:end . 248)\n  (:start . 237) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1.27.1) (:span 193 196)) ((:id . :x1.27.2) (:span 53 61)))\n (:hscopes ((:id . :x1.27.1) (:span 193 248))\n  ((:id . :x1.27.2) (:span 53 248)))\n (:identifiers (:sid . :s1.27) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100027@unknown@formal@none@1@S@This raises an interesting question:: ""Is there a 23rd amino acid"?".@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "”Is") (:form . "”Is") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 69) (:start . 68)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1.28.1) (:span 5 35)))\n (:hscopes ((:id . :x1.28.1) (:span 5 67)))\n (:identifiers (:sid . :s1.28) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100028@unknown@formal@none@1@S@If such an amino acid is discovered, it will deepen our understanding of the evolution and diversity of the genetic code.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 35)\n  (:start . 25) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "VB") (:stem . "deepen") (:form . "deepen") (:end . 51)\n  (:start . 45) (:id . 52))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 69) (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 86)\n  (:start . 77) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1.29) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100030@unknown@formal@none@1@S@Since both the 21st and 22nd amino acids are encoded by stop codons, the prime suspect is other stop codons (e.g. stop codon UAA), although the possibility of sense codons certainly remains.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "21st") (:form . "21st") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "22nd") (:form . "22nd") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "prime") (:form . "prime") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "suspect") (:form . "suspect") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 107)\n  (:start . 101) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 113) (:start . 109)\n  (:id . 64))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 118) (:start . 114)\n  (:id . 65))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 124)\n  (:start . 119) (:id . 66))\n ((:tag . "NNP") (:stem . "UAA") (:form . "UAA") (:end . 128) (:start . 125)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 69))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 139)\n  (:start . 131) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 71))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 155)\n  (:start . 144) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 164)\n  (:start . 159) (:id . 74))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 171)\n  (:start . 165) (:id . 75))\n ((:tag . "RB") (:stem . "certainly") (:form . "certainly") (:end . 181)\n  (:start . 172) (:id . 76))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 189)\n  (:start . 182) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1.31) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100031@unknown@formal@none@1@S@Using this clue, computational screening methods of the 23rd amino acid can be designed.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "clue") (:form . "clue") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "screening") (:form . "screening") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.32) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100032@unknown@formal@none@1@S@Recently, Lobanov et al. addressed this problem by searching tRNAs with anticodons corresponding to stop codons 14.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "Lobanov") (:form . "Lobanov") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "address") (:form . "addressed") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "search") (:form . "searching") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "trna") (:form . "tRNAs") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "anticodon") (:form . "anticodons") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 96)\n  (:start . 83) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "VB") (:stem . "stop") (:form . "stop") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 111)\n  (:start . 105) (:id . 58))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.33) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100033@unknown@formal@none@1@S@They analyzed 146 prokaryotic genomes, but no likely tRNA of the novel amino acid was detected.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "CD") (:stem . "146") (:form . "146") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1.34.1) (:span 43 45)))\n (:nscopes ((:id . :x1.34.1) (:span 43 94)))\n (:identifiers (:sid . :s1.34) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100034@unknown@formal@none@1@S@They concluded that the 23rd amino acid would have a limited phylogenetic distribution, if it exists.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "conclude") (:form . "concluded") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 73)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x1.35.1) (:span 40 45)))\n (:hscopes ((:id . :x1.35.1) (:span 40 100)))\n (:identifiers (:sid . :s1.35) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100035@unknown@formal@none@1@S@However, programs for tRNA identification are based on the features of known tRNAs and do not necessarily perform well on unknown ones.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 41) (:start . 27) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "trna") (:form . "tRNAs") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 105)\n  (:start . 94) (:id . 59))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.36) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100036@unknown@formal@none@1@S@Actually, tRNASec and tRNAPyl have unusual secondary structures 515 and often escape detection by programs without special consideration.@(((:tag . "RB") (:stem . "actually") (:form . "Actually") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "trnasec") (:form . "tRNASec") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "trnapyl") (:form . "tRNAPyl") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "CD") (:stem . "515") (:form . "515") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "escape") (:form . "escape") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "JJ") (:stem . "special") (:form . "special") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "NN") (:stem . "consideration") (:form . "consideration")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1.37.1) (:span 107 114)))\n (:nscopes ((:id . :x1.37.1) (:span 107 136)))\n (:identifiers (:sid . :s1.37) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100037@unknown@formal@none@1@S@Lobanov et al. thus developed a sensitive search method to deal with this problem, but they also admitted that it would fail to identify highly unusual tRNAs.@(((:tag . "NNP") (:stem . "Lobanov") (:form . "Lobanov") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VB") (:stem . "deal") (:form . "deal") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "admit") (:form . "admitted") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "VB") (:stem . "fail") (:form . "fail") (:end . 124) (:start . 120)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 136)\n  (:start . 128) (:id . 66))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "NNS") (:stem . "trna") (:form . "tRNAs") (:end . 157)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1.38.2) (:span 114 119)))\n (:ncues ((:id . :x1.38.1) (:span 120 124)))\n (:hscopes ((:id . :x1.38.2) (:span 114 157)))\n (:nscopes ((:id . :x1.38.1) (:span 120 157)))\n (:identifiers (:sid . :s1.38) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100038@unknown@formal@none@1@S@There is another approach to searching for the 23rd amino acid.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "search") (:form . "searching") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.39) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100040@unknown@formal@none@1@S@Because such an ORF-based study is independent from the tRNA analysis, it can either identify candidate organisms missed by the previous study or strengthen its negative conclusion.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "orf-based") (:form . "ORF-based") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "VBN") (:stem . "miss") (:form . "missed") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "VB") (:stem . "strengthen") (:form . "strengthen") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 169)\n  (:start . 161) (:id . 68))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 180)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1.41.1) (:span 78 84 143 145)))\n (:hscopes ((:id . :x1.41.1) (:span 78 180)))\n (:identifiers (:sid . :s1.41) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100041@unknown@formal@none@1@S@Here we report a comprehensive analysis of prokaryotic ORFs that contain an inframe stop codon.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 14)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "comprehensive") (:form . "comprehensive")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 54)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "orf") (:form . "ORFs") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.42) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100042@unknown@formal@none@1@S@Through enumeration of theoretical ORFs and inspection of their evolutionary conservation, candidates of readthrough proteins were predicted.@(((:tag . "IN") (:stem . "through") (:form . "Through") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "enumeration") (:form . "enumeration") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "theoretical") (:form . "theoretical") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "orf") (:form . "ORFs") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inspection") (:form . "inspection") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 63)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 89)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 116)\n  (:start . 105) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 125)\n  (:start . 117) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 130) (:start . 126)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 140)\n  (:start . 131) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.43) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100043@unknown@formal@none@1@S@They contained many of the known proteins with stop-codon-encoded amino acids, but almost no novel candidates were identified.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 65) (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.44) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100044@unknown@formal@none@1@S@Therefore, the unknown amino acid, if it is encoded by a stop codon, is unlikely to exist in the current databases of microbial genomes.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 51)\n  (:start . 44) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 61) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 67) (:start . 62)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "unlikely") (:form . "unlikely") (:end . 80)\n  (:start . 72) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 60))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 89) (:start . 84)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 104)\n  (:start . 97) (:id . 64))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 114)\n  (:start . 105) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 127)\n  (:start . 118) (:id . 67))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 135)\n  (:start . 128) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1.45.1) (:span 72 80)))\n (:hscopes ((:id . :x1.45.1) (:span 11 135)))\n (:identifiers (:sid . :s1.45) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100045@unknown@formal@none@1@S@The consequences for selenoproteins and other readthrough genes are also discussed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "consequence") (:form . "consequences") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.46) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100046@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.47) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100047@unknown@formal@none@1@S@Basic ideas@(((:tag . "JJ") (:stem . "basic") (:form . "Basic") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "idea") (:form . "ideas") (:end . 11) (:start . 6)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s1.48) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100048@unknown@formal@none@1@S@In this study, we focus on theoretical ORFs with one inframe stop codon, termed "interrupted ORFs" (iORFs) (Figure 1a).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "focus") (:form . "focus") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "theoretical") (:form . "theoretical") (:end . 38)\n  (:start . 27) (:id . 49))\n ((:tag . "NNS") (:stem . "orf") (:form . "ORFs") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 79) (:start . 73)\n  (:id . 57))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "interrupted") (:form . "interrupted") (:end . 92)\n  (:start . 81) (:id . 59))\n ((:tag . "NNS") (:stem . "orf") (:form . "ORFs") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 105)\n  (:start . 100) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 114)\n  (:start . 108) (:id . 66))\n ((:tag . "NN") (:stem . "1a") (:form . "1a") (:end . 117) (:start . 115)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.49) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100050@unknown@formal@none@1@S@However, the vast majority of the enumerated iORFs will be biologically meaningless.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "vast") (:form . "vast") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "enumerate") (:form . "enumerated") (:end . 44)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "meaningless") (:form . "meaningless") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.51) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100051@unknown@formal@none@1@S@To filter out such meaningless iORFs, we required the iORFs to have at least one homolog in other genomes, because evolutionary conservation of primary sequence is a strong indicator of functional importance.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "filter") (:form . "filter") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "meaningless") (:form . "meaningless") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "require") (:form . "required") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 88)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 105)\n  (:start . 98) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 127)\n  (:start . 115) (:id . 64))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 140)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . "NN") (:stem . "indicator") (:form . "indicator") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 196)\n  (:start . 186) (:id . 74))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 207)\n  (:start . 197) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s1.52) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100052@unknown@formal@none@1@S@However, this condition is not sufficient, since two major problems remain:: pseudogenes and two adjacent genes.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "condition") (:form . "condition") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "problem") (:form . "problems") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 88)\n  (:start . 77) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1.53.1) (:span 27 30)))\n (:nscopes ((:id . :x1.53.1) (:span 27 41)))\n (:identifiers (:sid . :s1.53) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100053@unknown@formal@none@1@S@The first problem is that even if an iORF has homologs in other species, it could be a pseudogene or a product of sequencing error.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 81) (:start . 76)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pseudogene") (:form . "pseudogene") (:end . 97)\n  (:start . 87) (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 110)\n  (:start . 103) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 65))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 124)\n  (:start . 114) (:id . 66))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 130)\n  (:start . 125) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x1.54.1) (:span 98 100)) ((:id . :x1.54.2) (:span 76 81)))\n (:hscopes ((:id . :x1.54.1) (:span 85 130))\n  ((:id . :x1.54.2) (:span 76 130)))\n (:identifiers (:sid . :s1.54) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100054@unknown@formal@none@1@S@The second problem is that adjacent genes on the same reading frame may satisfy the condition of conserved iORFs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "VB") (:stem . "satisfy") (:form . "satisfy") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "condition") (:form . "condition") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x1.55.1) (:span 68 71)))\n (:hscopes ((:id . :x1.55.1) (:span 68 112)))\n (:identifiers (:sid . :s1.55) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100055@unknown@formal@none@1@S@In particular, gene pairs within an operon are problematic because their gene arrangement is often conserved.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "operon") (:form . "operon") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "problematic") (:form . "problematic") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 72)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "arrangement") (:form . "arrangement") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1.56) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100056@unknown@formal@none@1@S@If the intergenic distance between two genes in an operon happens to be a multiple of three, they look like a conserved readthrough gene.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "intergenic") (:form . "intergenic") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "distance") (:form . "distance") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "operon") (:form . "operon") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "VBZ") (:stem . "happen") (:form . "happens") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "multiple") (:form . "multiple") (:end . 82)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 97) (:start . 93)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "look") (:form . "look") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 119)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 131)\n  (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1.57.1) (:span 98 107)) ((:id . :x1.57.2) (:span 58 65)))\n (:hscopes ((:id . :x1.57.1) (:span 98 136)) ((:id . :x1.57.2) (:span 3 91)))\n (:identifiers (:sid . :s1.57) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100057@unknown@formal@none@1@S@Basic ideas of the prediction method@(((:tag . "JJ") (:stem . "basic") (:form . "Basic") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "idea") (:form . "ideas") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 36)\n  (:start . 30) (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.58) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100058@unknown@formal@none@1@S@Basic ideas of the prediction method.@(((:tag . "JJ") (:stem . "basic") (:form . "Basic") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "idea") (:form . "ideas") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 37) (:start . 36)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1.59) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100060@unknown@formal@none@1@S@(b) Readthrough genes can be distinguished from two adjacent genes based on the results of BLAST searches.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "b") (:form . "b") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "IN") (:stem . "readthrough") (:form . "Readthrough") (:end . 15)\n  (:start . 4) (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "distinguish") (:form . "distinguished") (:end . 42)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.61) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100061@unknown@formal@none@1@S@Boxes denote iORFs, and × indicates the inframe stop codon.@(((:tag . "NNPS") (:stem . "Box") (:form . "Boxes") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "×") (:form . "×") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 47)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.62) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100062@unknown@formal@none@1@S@Shaded regions represent actual protein-coding regions.@(((:tag . "JJ") (:stem . "shaded") (:form . "Shaded") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "JJ") (:stem . "protein-coding") (:form . "protein-coding")\n  (:end . 46) (:start . 32) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 54)\n  (:start . 47) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1.63) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100063@unknown@formal@none@1@S@If an iORF codes a readthrough protein, BLAST hits from other organisms will cover the inframe stop codon.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "cod") (:form . "codes") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 30)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.64) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100064@unknown@formal@none@1@S@In contrast, if the iORF consists of two adjacent genes, many hits that do not cover the inframe stop codon will be found.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 33)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 84) (:start . 79)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 96)\n  (:start . 89) (:id . 61))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 101) (:start . 97)\n  (:id . 62))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 107)\n  (:start . 102) (:id . 63))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 112) (:start . 108)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 121)\n  (:start . 116) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1.65.1) (:span 75 78)))\n (:nscopes ((:id . :x1.65.1) (:span 75 107)))\n (:identifiers (:sid . :s1.65) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100065@unknown@formal@none@1@S@To discriminate them from true readthrough genes, evolutionary information was exploited.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "discriminate") (:form . "discriminate") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 74)\n  (:start . 63) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "exploit") (:form . "exploited") (:end . 88)\n  (:start . 79) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.66) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100066@unknown@formal@none@1@S@In order to eliminate pseudogenes and sequencing errors, conservation of iORFs and their inframe stop codons was examined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "eliminate") (:form . "eliminate") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "error") (:form . "errors") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 88)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.67) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100067@unknown@formal@none@1@S@Since pseudogenes are less conserved, and sequencing errors are relatively rare events, they will not have homologous iORFs in other species.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "error") (:form . "errors") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 123)\n  (:start . 118) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 140)\n  (:start . 133) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1.68.1) (:span 98 101)))\n (:nscopes ((:id . :x1.68.1) (:span 98 140)))\n (:identifiers (:sid . :s1.68) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100068@unknown@formal@none@1@S@Even if they do, the position or type (UAA, UAG or UGA) of their inframe stop codons will not coincide.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 29)\n  (:start . 21) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 37) (:start . 33)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "UAA") (:form . "UAA") (:end . 42) (:start . 39)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "UAG") (:form . "UAG") (:end . 47) (:start . 44)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 50) (:start . 48)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "UGA") (:form . "UGA") (:end . 54) (:start . 51)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 64)\n  (:start . 59) (:id . 59))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 72)\n  (:start . 65) (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 77) (:start . 73)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 84)\n  (:start . 78) (:id . 62))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 89) (:start . 85)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 64))\n ((:tag . "VB") (:stem . "coincide") (:form . "coincide") (:end . 102)\n  (:start . 94) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1.69.1) (:span 90 93)))\n (:nscopes ((:id . :x1.69.1) (:span 90 102)))\n (:identifiers (:sid . :s1.69) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100070@unknown@formal@none@1@S@A drawback of this criterion is that it limits the target of our study to readthrough genes conserved across two or more species.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "drawback") (:form . "drawback") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "criterion") (:form . "criterion") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "limit") (:form . "limits") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 85)\n  (:start . 74) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.71) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100071@unknown@formal@none@1@S@In other words, species-specific readthrough genes are not in the scope of this study.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "word") (:form . "words") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "species-specific") (:form . "species-specific")\n  (:end . 32) (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "scope") (:form . "scope") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1.72.1) (:span 55 58)))\n (:nscopes ((:id . :x1.72.1) (:span 55 85)))\n (:identifiers (:sid . :s1.72) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100072@unknown@formal@none@1@S@To address the second problem, adjacent gene pairs were filtered out by examining boundaries of sequence alignments between iORFs and its homologs (Figure 1b).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "examine") (:form . "examining") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "boundary") (:form . "boundaries") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "1b") (:form . "1b") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.73) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100073@unknown@formal@none@1@S@The stop-codon-encoded amino acids of prokaryotes are usually located inside domains, the units of evolutionary sequence conservation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 28) (:start . 23)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 49)\n  (:start . 38) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "inside") (:form . "inside") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 84)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "unit") (:form . "units") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 111)\n  (:start . 99) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 133)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.74) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100074@unknown@formal@none@1@S@Therefore, the aligned regions of readthrough proteins contain their inframe stop codon.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "aligned") (:form . "aligned") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 68)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.75) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100075@unknown@formal@none@1@S@Based on this observation, each iORF was required to have:: (i) at least one homolog from other organisms that covers the inframe stop codon and (ii) no homolog that does not cover the stop codon.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "LS") (:stem . "i") (:form . "i") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 66) (:start . 64)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 72) (:start . 67)\n  (:id . 59))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 76) (:start . 73)\n  (:id . 60))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 84)\n  (:start . 77) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 95) (:start . 90)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 105)\n  (:start . 96) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "cover") (:form . "covers") (:end . 117)\n  (:start . 111) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 129)\n  (:start . 122) (:id . 68))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 134) (:start . 130)\n  (:id . 69))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 140)\n  (:start . 135) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 72))\n ((:tag . "LS") (:stem . "ii") (:form . "ii") (:end . 148) (:start . 146)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 74))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 152) (:start . 150)\n  (:id . 75))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 160)\n  (:start . 153) (:id . 76))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 77))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 170) (:start . 166)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 174) (:start . 171)\n  (:id . 79))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 180)\n  (:start . 175) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 81))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 189) (:start . 185)\n  (:id . 82))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 195)\n  (:start . 190) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x1.76.1) (:span 171 174))\n  ((:id . :x1.76.2) (:span 150 152)))\n (:nscopes ((:id . :x1.76.1) (:span 171 195))\n  ((:id . :x1.76.2) (:span 150 195)))\n (:identifiers (:sid . :s1.76) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100076@unknown@formal@none@1@S@Note that, however, if the whole length of an iORF was used as a query sequence, this procedure will erroneously discard multidomain readthrough proteins.@(((:tag . "VB") (:stem . "note") (:form . "Note") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 32) (:start . 27)\n  (:id . 49))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 50) (:start . 46)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 59) (:start . 55)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 62) (:start . 60)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 70) (:start . 65)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 79)\n  (:start . 71) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 85) (:start . 81)\n  (:id . 61))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 95)\n  (:start . 86) (:id . 62))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 100) (:start . 96)\n  (:id . 63))\n ((:tag . "RB") (:stem . "erroneously") (:form . "erroneously") (:end . 112)\n  (:start . 101) (:id . 64))\n ((:tag . "VB") (:stem . "discard") (:form . "discard") (:end . 120)\n  (:start . 113) (:id . 65))\n ((:tag . "JJ") (:stem . "multidomain") (:form . "multidomain") (:end . 132)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 144)\n  (:start . 133) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 153)\n  (:start . 145) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.77) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100077@unknown@formal@none@1@S@To avoid this problem, a partial sequence around the inframe stop codon was used as a query.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.78) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100078@unknown@formal@none@1@S@Prediction procedure@(((:tag . "NN") (:stem . "prediction") (:form . "Prediction") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 20)\n  (:start . 11) (:id . 43)))@@@1@2@((:identifiers (:sid . :s1.79) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100080@unknown@formal@none@1@S@A total of 191 prokaryotes were analyzed in this study, of which 166 are bacteria and 25 are archaea.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 26)\n  (:start . 15) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 54))\n ((:tag . "CD") (:stem . "166") (:form . "166") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "archaea") (:form . "archaea") (:end . 100)\n  (:start . 93) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.81) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100081@unknown@formal@none@1@S@They were selected from 328 prokaryotes with completely sequenced genomes by excluding closely related species.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "328") (:form . "328") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.82) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100082@unknown@formal@none@1@S@From the genome sequences of the 191 organisms, all possible iORFs were enumerated.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "enumerate") (:form . "enumerated") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.83) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100083@unknown@formal@none@1@S@Two conditions were imposed on the geometry of the iORFs (Figure 1a).@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "impose") (:form . "imposed") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "geometry") (:form . "geometry") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "1a") (:form . "1a") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.84) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100084@unknown@formal@none@1@S@First, only iORFs longer than 80 codons were extracted.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 24) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.85) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100085@unknown@formal@none@1@S@Secondly, margins between the inframe stop codon and both termini of the iORF must be longer than 10 codons.@(((:tag . "RB") (:stem . "secondly") (:form . "Secondly") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "margin") (:form . "margins") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 92) (:start . 86)\n  (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.86) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100086@unknown@formal@none@1@S@The total number of iORFs extracted under these conditions was 2,969,958.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "2,969,958") (:form . "2,969,958") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.87) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100087@unknown@formal@none@1@S@Next, iORFs that overlap RNA genes or protein-coding genes in different reading frames were discarded.@(((:tag . "RB") (:stem . "next") (:form . "Next") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "protein-coding") (:form . "protein-coding")\n  (:end . 52) (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.88) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100088@unknown@formal@none@1@S@This test significantly reduced the number of iORFs to 390,926.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "CD") (:stem . "390,926") (:form . "390,926") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.89) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100090@unknown@formal@none@1@S@A flowchart of the prediction procedure.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "flowchart") (:form . "flowchart") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 40) (:start . 39)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1.91) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100091@unknown@formal@none@1@S@Several steps are omitted for simplicity.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "omit") (:form . "omitted") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "simplicity") (:form . "simplicity") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 41) (:start . 40)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s1.92) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100092@unknown@formal@none@1@S@Detailed explanation is given in the text.@(((:tag . "JJ") (:stem . "detailed") (:form . "Detailed") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "text") (:form . "text") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1.93) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100093@unknown@formal@none@1@S@As noted above, the target of this study is evolutionarily conserved iORFs.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "above") (:form . "above") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 58) (:start . 44) (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.94) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100094@unknown@formal@none@1@S@Thus, it was examined whether the iORFs have homologous regions in other genomes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 21)\n  (:start . 13) (:id . 46))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x1.95.1) (:span 22 29)))\n (:hscopes ((:id . :x1.95.1) (:span 22 80)))\n (:identifiers (:sid . :s1.95) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100095@unknown@formal@none@1@S@The 390,926 iORFs were translated into amino acid sequences and subjected to TBLASTN 16 against the 191 genome sequences.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "390,926") (:form . "390,926") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "TBLASTN") (:form . "TBLASTN") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.96) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100096@unknown@formal@none@1@S@Instead of the whole length of the amino acid sequence, a window of 101 residues centered at the inframe stop codon was used as a BLAST query.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "window") (:form . "window") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "CD") (:stem . "101") (:form . "101") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 80)\n  (:start . 72) (:id . 57))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 104)\n  (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 124) (:start . 120)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 67))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 135)\n  (:start . 130) (:id . 68))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 141)\n  (:start . 136) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1.97.1) (:span 0 10)))\n (:nscopes ((:id . :x1.97.1) (:span 0 54)))\n (:identifiers (:sid . :s1.97) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100097@unknown@formal@none@1@S@After the BLAST searches, iORFs that have at least one interspecific hit that contains the inframe stop codon were collected.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "interspecific") (:form . "interspecific")\n  (:end . 68) (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "hit") (:form . "hit") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "collect") (:form . "collected") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.98) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100098@unknown@formal@none@1@S@Whether the codon aligned to the inframe stop codon is a nonsense codon or not was neglected at this stage.@(((:tag . "IN") (:stem . "whether") (:form . "Whether") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "align") (:form . "aligned") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nonsense") (:form . "nonsense") (:end . 65)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "neglect") (:form . "neglected") (:end . 92)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x1.99.2) (:span 72 74)) ((:id . :x1.99.3) (:span 0 7)))\n (:ncues ((:id . :x1.99.1) (:span 75 78)))\n (:hscopes ((:id . :x1.99.2) (:span 55 78)) ((:id . :x1.99.3) (:span 0 78)))\n (:nscopes ((:id . :x1.99.1) (:span 75 78)))\n (:identifiers (:sid . :s1.99) (:did . :1471-2105-8-225) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100100@unknown@formal@none@1@S@The result of the above homology searches was also used for the boundary analysis (Figure 1b).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "boundary") (:form . "boundary") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "1b") (:form . "1b") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.101) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100101@unknown@formal@none@1@S@An iORF was discarded if there were any BLAST hits that do not cover the inframe stop codon.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 68) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 80)\n  (:start . 73) (:id . 57))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1.102.1) (:span 59 62)))\n (:nscopes ((:id . :x1.102.1) (:span 59 91)))\n (:identifiers (:sid . :s1.102) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100102@unknown@formal@none@1@S@A total of 26,003 iORF satisfied the above criteria.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "26,003") (:form . "26,003") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "satisfy") (:form . "satisfied") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1.103) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100103@unknown@formal@none@1@S@To examine intrafamily conservation of the inframe stop codons, these iORFs were clustered into protein families based on sequence similarity.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "intrafamily") (:form . "intrafamily") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 35)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "cluster") (:form . "clustered") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.104) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100104@unknown@formal@none@1@S@After removal of singletons, 679 clusters with two or more members were obtained.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "singleton") (:form . "singletons") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "679") (:form . "679") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.105) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100105@unknown@formal@none@1@S@A cluster was discarded unless all members of the cluster had the same type of inframe stop codons (UAA, UAG or UGA).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "UAA") (:form . "UAA") (:end . 103) (:start . 100)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "UAG") (:form . "UAG") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 111) (:start . 109)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "UGA") (:form . "UGA") (:end . 115) (:start . 112)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1.106) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100106@unknown@formal@none@1@S@The locations of the inframe stop codons were also required to be identical in the multiple sequence alignment of the cluster members.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "location") (:form . "locations") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1.107) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100107@unknown@formal@none@1@S@These conditions reduced the number of clusters to 273.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "273") (:form . "273") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1.108) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100108@unknown@formal@none@1@S@Manual inspection of these 273 clusters revealed that they still contain many false positives that are unrelated to stop-codon-encoded amino acids.@(((:tag . "JJ") (:stem . "manual") (:form . "Manual") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inspection") (:form . "inspection") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "273") (:form . "273") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 134) (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 140)\n  (:start . 135) (:id . 61))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 146)\n  (:start . 141) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.109) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100110@unknown@formal@none@1@S@Briefly, the first filter assesses protein-likeliness based on the signal of purifying selection, while the second and third filters try to remove adjacent gene pairs using the pattern of BLAST alignments (for details, see Materials and Methods).@(((:tag . "NNP") (:stem . "Briefly") (:form . "Briefly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "filter") (:form . "filter") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "assess") (:form . "assesses") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "protein-likeliness") (:form . "protein-likeliness")\n  (:end . 53) (:start . 35) (:id . 48))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 59) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "purify") (:form . "purifying") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "filter") (:form . "filters") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "VBP") (:stem . "try") (:form . "try") (:end . 136) (:start . 133)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VB") (:stem . "remove") (:form . "remove") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 160) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 166)\n  (:start . 161) (:id . 68))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 172) (:start . 167)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 184)\n  (:start . 177) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 193)\n  (:start . 188) (:id . 73))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 204)\n  (:start . 194) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 217)\n  (:start . 210) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 218) (:start . 217)\n  (:id . 78))\n ((:tag . "VBP") (:stem . "see") (:form . "see") (:end . 222) (:start . 219)\n  (:id . 79))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 232)\n  (:start . 223) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 81))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 244)\n  (:start . 237) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 245) (:start . 244)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s1.111) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100111@unknown@formal@none@1@S@As a result of the filtering, the number of candidate clusters was reduced to 32.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "filtering") (:form . "filtering") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 40)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 53)\n  (:start . 44) (:id . 52))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.112) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100112@unknown@formal@none@1@S@Through manual inspection of the BLAST alignments, 11 clusters were discarded because they are highly unlikely to code readthrough proteins.@(((:tag . "IN") (:stem . "through") (:form . "Through") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "manual") (:form . "manual") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "inspection") (:form . "inspection") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "JJ") (:stem . "unlikely") (:form . "unlikely") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "VB") (:stem . "code") (:form . "code") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 139)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x1.113.1) (:span 102 110)))\n (:hscopes ((:id . :x1.113.1) (:span 86 139)))\n (:identifiers (:sid . :s1.113) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100113@unknown@formal@none@1@S@Known proteins in the predicted clusters@(((:tag . "NN") (:stem . "known") (:form . "Known") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 40)\n  (:start . 32) (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.114) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100114@unknown@formal@none@1@S@The clusters predicted by our method are summarized in Table 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "summarize") (:form . "summarized") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.115) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100115@unknown@formal@none@1@S@Of the 21 clusters, 15 were known selenoproteins, and four were known pyrrolysine proteins.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 48) (:start . 34) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 81)\n  (:start . 70) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.116) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100116@unknown@formal@none@1@S@To assess the sensitivity of our method, the result was compared with a list of prokaryotic selenoproteins reported by Kryukov and Gladyshev 12.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 64)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 91)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 106) (:start . 92) (:id . 59))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Kryukov") (:form . "Kryukov") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Gladyshev") (:form . "Gladyshev") (:end . 140)\n  (:start . 131) (:id . 64))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1.117) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100117@unknown@formal@none@1@S@Since our target is readthrough genes conserved across two or more species, such selenoprotein families were selected from their list.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.118) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100118@unknown@formal@none@1@S@There were 15 families satisfying this criterion, but one family, proline reductase, was excluded because it was found in only one organism in our dataset.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBG") (:stem . "satisfy") (:form . "satisfying") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "criterion") (:form . "criterion") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proline") (:form . "proline") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "reductase") (:form . "reductase") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "exclude") (:form . "excluded") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 154)\n  (:start . 147) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1.119) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100120@unknown@formal@none@1@S@The three families we failed to find were SelW-like protein, peroxiredoxin and thiol:protein disulphide oxidoreductase.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 28) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "selw-like") (:form . "SelW-like") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "peroxiredoxin") (:form . "peroxiredoxin")\n  (:end . 74) (:start . 61) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "thiol:protein") (:form . "thiol:protein")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "disulphide") (:form . "disulphide") (:end . 103)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "oxidoreductase") (:form . "oxidoreductase")\n  (:end . 118) (:start . 104) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1.121.1) (:span 22 28)))\n (:nscopes ((:id . :x1.121.1) (:span 22 36)))\n (:identifiers (:sid . :s1.121) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100121@unknown@formal@none@1@S@SelW-like protein was below the threshold of detection, because its stop codon is near the N-terminus and the amino acid sequences of its members are too divergent.@(((:tag . "JJ") (:stem . "selw-like") (:form . "SelW-like") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "N-terminus") (:form . "N-terminus") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 145)\n  (:start . 138) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "divergent") (:form . "divergent") (:end . 163)\n  (:start . 154) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1.122) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100122@unknown@formal@none@1@S@The reason why the two other families were not detected is more complex.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reason") (:form . "reason") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1.123.1) (:span 43 46)))\n (:nscopes ((:id . :x1.123.1) (:span 15 55)))\n (:identifiers (:sid . :s1.123) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100123@unknown@formal@none@1@S@Since these two families are homologous, they were grouped into an identical cluster at the clustering stage of our method.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "clustering") (:form . "clustering") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.124) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100124@unknown@formal@none@1@S@However, the positions of selenocysteine were different between the two families (Figure 3).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 40) (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.125) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100125@unknown@formal@none@1@S@The cluster was thus discarded because of an apparent lack of stop codon conservation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 85)\n  (:start . 73) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x1.126.2) (:span 45 53)))\n (:ncues ((:id . :x1.126.1) (:span 54 58)))\n (:hscopes ((:id . :x1.126.2) (:span 45 85)))\n (:nscopes ((:id . :x1.126.1) (:span 54 85)))\n (:identifiers (:sid . :s1.126) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100126@unknown@formal@none@1@S@To deal with a situation like this, a reexamination of the clustering threshold and subdivision of clusters will be required.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "deal") (:form . "deal") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "situation") (:form . "situation") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reexamination") (:form . "reexamination")\n  (:end . 51) (:start . 38) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "clustering") (:form . "clustering") (:end . 69)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 79)\n  (:start . 70) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subdivision") (:form . "subdivision") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.127) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100127@unknown@formal@none@1@S@Predicted clusters of readthrough proteins@(((:tag . "VBN") (:stem . "predict") (:form . "Predicted") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 42)\n  (:start . 34) (:id . 46)))@@@1@5@((:identifiers (:sid . :s1.128) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5100128@unknown@formal@none@1@S@A plus sign in a locus indicates that the genomic coordinates of the iORF can be described by a concatenation of two genes or regions.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sign") (:form . "sign") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "coordinate") (:form . "coordinates") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 90)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "concatenation") (:form . "concatenation")\n  (:end . 109) (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 122)\n  (:start . 117) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 133)\n  (:start . 126) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1.129.1) (:span 123 125))\n  ((:id . :x1.129.2) (:span 23 37)))\n (:hscopes ((:id . :x1.129.1) (:span 117 133))\n  ((:id . :x1.129.2) (:span 23 133)))\n (:identifiers (:sid . :s1.129) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100130@unknown@formal@none@1@S@HesB family was not clustered into one family, because their sequences were too short and diverged.@(((:tag . "NNP") (:stem . "HesB") (:form . "HesB") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "cluster") (:form . "clustered") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 60)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x1.131.1) (:span 16 19)))\n (:nscopes ((:id . :x1.131.1) (:span 0 45)))\n (:identifiers (:sid . :s1.131) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100131@unknown@formal@none@1@S@Selenoprotein families we failed to detect because of nonconserved location of stop codons@(((:tag . "NNP") (:stem . "Selenoprotein") (:form . "Selenoprotein")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 32) (:start . 26)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nonconserved") (:form . "nonconserved") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 90)\n  (:start . 84) (:id . 54)))@@@1@13@((:ncues ((:id . :x1.132.1) (:span 26 32)))\n (:nscopes ((:id . :x1.132.1) (:span 0 42)))\n (:identifiers (:sid . :s1.132) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100132@unknown@formal@none@1@S@Selenoprotein families we failed to detect because of nonconserved location of stop codons.@(((:tag . "NNP") (:stem . "Selenoprotein") (:form . "Selenoprotein")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 32) (:start . 26)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "nonconserved") (:form . "nonconserved") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 90)\n  (:start . 84) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1.133.1) (:span 26 32)))\n (:nscopes ((:id . :x1.133.1) (:span 0 42)))\n (:identifiers (:sid . :s1.133) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100133@unknown@formal@none@1@S@Selenocysteine residues of Peroxiredoxin-like protein families constitute homologous redox motifs (TXXU and UXXC), but their positions are different between two families.@(((:tag . "NNP") (:stem . "Selenocysteine") (:form . "Selenocysteine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "peroxiredoxin-like") (:form . "Peroxiredoxin-like")\n  (:end . 45) (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 46))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 62)\n  (:start . 54) (:id . 47))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 73)\n  (:start . 63) (:id . 48))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 84)\n  (:start . 74) (:id . 49))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 90) (:start . 85)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 97)\n  (:start . 91) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "TXXU") (:form . "TXXU") (:end . 103) (:start . 99)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "UXXC") (:form . "UXXC") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 134)\n  (:start . 125) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 148)\n  (:start . 139) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 156)\n  (:start . 149) (:id . 63))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 169)\n  (:start . 161) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1.134) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100134@unknown@formal@none@1@S@Columns are colored according to sequence conservation.@(((:tag . "NNS") (:stem . "column") (:form . "Columns") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "color") (:form . "colored") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1.135) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100135@unknown@formal@none@1@S@Selenocysteine residues are shown in red, and the other residues in the redox motifs are shown in yellow.@(((:tag . "NNP") (:stem . "Selenocysteine") (:form . "Selenocysteine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "redox") (:form . "redox") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "yellow") (:form . "yellow") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.136) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100136@unknown@formal@none@1@S@Prx; Peroxiredoxin, TPO; thiol:protein disulphide oxidereductase, Adeh; Anaeromyxobacter dehalogenans, Gmet; Geobacter metallireducens, Gsul; G. sulfurreducens, Dpsy; Desulfotalea psychrophila.@(((:tag . "NNP") (:stem . "Prx") (:form . "Prx") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "Peroxiredoxin") (:form . "Peroxiredoxin")\n  (:end . 18) (:start . 5) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TPO") (:form . "TPO") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "thiol:protein") (:form . "thiol:protein")\n  (:end . 38) (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "disulphide") (:form . "disulphide") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "oxidereductase") (:form . "oxidereductase")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Adeh") (:form . "Adeh") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Anaeromyxobacter") (:form . "Anaeromyxobacter")\n  (:end . 88) (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "dehalogenan") (:form . "dehalogenans") (:end . 101)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Gmet") (:form . "Gmet") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Geobacter") (:form . "Geobacter") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "metallireducen") (:form . "metallireducens")\n  (:end . 134) (:start . 119) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Gsul") (:form . "Gsul") (:end . 140) (:start . 136)\n  (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "sulfurreducen") (:form . "sulfurreducens")\n  (:end . 159) (:start . 145) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Dpsy") (:form . "Dpsy") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Desulfotalea") (:form . "Desulfotalea")\n  (:end . 179) (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "psychrophila") (:form . "psychrophila") (:end . 192)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1.137) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100137@unknown@formal@none@1@S@The alignments were computed using ClustalW, and the figures were generated using Jalview.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ClustalW") (:form . "ClustalW") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "figure") (:form . "figures") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Jalview") (:form . "Jalview") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.138) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100138@unknown@formal@none@1@S@Of the four pyrrolysine proteins detected, three methylamine methyltransferases have been experimentally confirmed to contain pyrrolysine 617.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "methylamine") (:form . "methylamine") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "methyltransferas") (:form . "methyltransferases")\n  (:end . 79) (:start . 61) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 104) (:start . 90) (:id . 54))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 114)\n  (:start . 105) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 56))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 125)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 137)\n  (:start . 126) (:id . 58))\n ((:tag . "CD") (:stem . "617") (:form . "617") (:end . 141) (:start . 138)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.139) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100140@unknown@formal@none@1@S@Since the genome annotation of M. acetivorans describes this protein as a gene containing an inframe amber codon, we classified it as a ''known'' candidate, although it is still unclear whether it really contains pyrrolysine.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "annotation") (:form . "annotation") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "acetivoran") (:form . "acetivorans") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "VBZ") (:stem . "describe") (:form . "describes") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "amber") (:form . "amber") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "classify") (:form . "classified") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 135) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 143) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 155)\n  (:start . 146) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 70))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 165)\n  (:start . 157) (:id . 71))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 168) (:start . 166)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 177)\n  (:start . 172) (:id . 74))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 185)\n  (:start . 178) (:id . 75))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 193)\n  (:start . 186) (:id . 76))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 196) (:start . 194)\n  (:id . 77))\n ((:tag . "RB") (:stem . "really") (:form . "really") (:end . 203)\n  (:start . 197) (:id . 78))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 212)\n  (:start . 204) (:id . 79))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 224)\n  (:start . 213) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x1.141.1) (:span 186 193))\n  ((:id . :x1.141.2) (:span 178 185)))\n (:hscopes ((:id . :x1.141.1) (:span 186 224))\n  ((:id . :x1.141.2) (:span 178 224)))\n (:identifiers (:sid . :s1.141) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100141@unknown@formal@none@1@S@The genome annotation of M. acetivorans also includes several amber-containing genes that were absent from our prediction result.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "annotation") (:form . "annotation") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "acetivoran") (:form . "acetivorans") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "amber-containing") (:form . "amber-containing")\n  (:end . 78) (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 84) (:start . 79)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x1.142.1) (:span 95 101)))\n (:nscopes ((:id . :x1.142.1) (:span 85 128)))\n (:identifiers (:sid . :s1.142) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100142@unknown@formal@none@1@S@They are a methlycobamide:CoM methylase and four transposases 18.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "methlycobamide:CoM") (:form . "methlycobamide:CoM")\n  (:end . 29) (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "methylase") (:form . "methylase") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "transposas") (:form . "transposases") (:end . 61)\n  (:start . 49) (:id . 49))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1.143) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100143@unknown@formal@none@1@S@The reason why they were not detected is that only one species in our dataset had an amber-containing form of these proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reason") (:form . "reason") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "amber-containing") (:form . "amber-containing")\n  (:end . 101) (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x1.144.1) (:span 25 28)))\n (:nscopes ((:id . :x1.144.1) (:span 15 37)))\n (:identifiers (:sid . :s1.144) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100144@unknown@formal@none@1@S@This is unavoidable because of the inability of our method to detect species-specific readthrough events.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unavoidable") (:form . "unavoidable") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inability") (:form . "inability") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "JJ") (:stem . "species-specific") (:form . "species-specific")\n  (:end . 85) (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.145) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100145@unknown@formal@none@1@S@It is the price for reliably excluding pseudogenes and sequencing errors.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "price") (:form . "price") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "reliably") (:form . "reliably") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 65)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "error") (:form . "errors") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.146) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100146@unknown@formal@none@1@S@Unknown candidates in the predicted clusters@(((:tag . "JJ") (:stem . "unknown") (:form . "Unknown") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 44)\n  (:start . 36) (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.147) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100147@unknown@formal@none@1@S@The successful detection of many known proteins is encouraging, because our method relies only on general properties of proteins that contain stop-codon-encoded amino acids, but not on specific features of selenocysteine or pyrrolysine.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "encourage") (:form . "encouraging") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "VBZ") (:stem . "rely") (:form . "relies") (:end . 89) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 160) (:start . 142) (:id . 64))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 166)\n  (:start . 161) (:id . 65))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 177) (:start . 174)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 193)\n  (:start . 185) (:id . 71))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 202)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 220) (:start . 206) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 223) (:start . 221)\n  (:id . 75))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 235)\n  (:start . 224) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x1.148.1) (:span 178 181)))\n (:nscopes ((:id . :x1.148.1) (:span 178 235)))\n (:identifiers (:sid . :s1.148) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100148@unknown@formal@none@1@S@Therefore, unknown clusters in our candidates have possibilities for the 23rd amino acid or novel readthrough proteins.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "possibility") (:form . "possibilities") (:end . 64)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.149) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100150@unknown@formal@none@1@S@The first cluster is comprised of c-type cytochromes from δ-proteobacteria Geobacter sulfurreducens and G. metallireducens.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "comprise") (:form . "comprised") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "c-type") (:form . "c-type") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "cytochrome") (:form . "cytochromes") (:end . 52)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "δ-proteobacteria") (:form . "δ-proteobacteria")\n  (:end . 74) (:start . 58) (:id . 51))\n ((:tag . "NNP") (:stem . "Geobacter") (:form . "Geobacter") (:end . 84)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "sulfurreducen") (:form . "sulfurreducens")\n  (:end . 99) (:start . 85) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "metallireducen") (:form . "metallireducens")\n  (:end . 122) (:start . 107) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.151) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100151@unknown@formal@none@1@S@The N-terminal part of the sequence contains five CXXCH heme-biding motifs, while the C-terminal part has no similarity with any characterized proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "CXXCH") (:form . "CXXCH") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heme-biding") (:form . "heme-biding") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 142) (:start . 129) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x1.152.1) (:span 106 108)))\n (:nscopes ((:id . :x1.152.1) (:span 106 151)))\n (:identifiers (:sid . :s1.152) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100152@unknown@formal@none@1@S@Homology search against unfinished microbial genomes identified seven homologous proteins from four other δ-proteobacteria species.@(((:tag . "NNP") (:stem . "Homology") (:form . "Homology") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "JJ") (:stem . "unfinished") (:form . "unfinished") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 52)\n  (:start . 45) (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 63)\n  (:start . 53) (:id . 48))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 80)\n  (:start . 70) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 52))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 99) (:start . 95)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 105)\n  (:start . 100) (:id . 54))\n ((:tag . "NNP") (:stem . "δ-proteobacteria") (:form . "δ-proteobacteria")\n  (:end . 122) (:start . 106) (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 130)\n  (:start . 123) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.153) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100153@unknown@formal@none@1@S@Multiple sequence alignment of these sequences is shown in Figure 4a.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "4a") (:form . "4a") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.154) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100154@unknown@formal@none@1@S@Multiple sequence alignments of novel candidate proteins@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 48)))@@@1@7@((:identifiers (:sid . :s1.155) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100155@unknown@formal@none@1@S@Multiple sequence alignments of novel candidate proteins.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1.156) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100156@unknown@formal@none@1@S@(a) A selenoprotein candidate from Geobacter sulfurreducens and its homologs.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "a") (:form . "a") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 5) (:start . 4)\n  (:id . 45))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 19) (:start . 6) (:id . 46))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Geobacter") (:form . "Geobacter") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "sulfurreducen") (:form . "sulfurreducens")\n  (:end . 59) (:start . 45) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.157) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100157@unknown@formal@none@1@S@The possible selenocysteine residues are shown in red, and putative heme-binding motifs are underlined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 67)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "heme-binding") (:form . "heme-binding") (:end . 80)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "underline") (:form . "underlined") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1.158.1) (:span 59 67)) ((:id . :x1.158.2) (:span 4 12)))\n (:hscopes ((:id . :x1.158.1) (:span 59 87)) ((:id . :x1.158.2) (:span 4 36)))\n (:identifiers (:sid . :s1.158) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100158@unknown@formal@none@1@S@Note that sequence conservation near the selenocysteine is comparable to that of the N-terminal cytochrome domain.@(((:tag . "VB") (:stem . "note") (:form . "Note") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 55) (:start . 41) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 106)\n  (:start . 96) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.159) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100160@unknown@formal@none@1@S@It will be either a sequencing error or a pseudogene.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 17)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pseudogene") (:form . "pseudogene") (:end . 52)\n  (:start . 42) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x1.161.1) (:span 11 17 37 39)))\n (:hscopes ((:id . :x1.161.1) (:span 11 52)))\n (:identifiers (:sid . :s1.161) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100161@unknown@formal@none@1@S@Gsul; G. sulfurreducens, Gmet; G. metallireducens, Gura; G. uraniumreducens, Gfrc; Geobacter sp. FRC-32, Dace; Desulfuromonas acetoxidans, Dpro; Delta proteobacterium MLMS-1.@(((:tag . "NNP") (:stem . "Gsul") (:form . "Gsul") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "sulfurreducen") (:form . "sulfurreducens")\n  (:end . 23) (:start . 9) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Gmet") (:form . "Gmet") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "metallireducen") (:form . "metallireducens")\n  (:end . 49) (:start . 34) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Gura") (:form . "Gura") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "uraniumreducen") (:form . "uraniumreducens")\n  (:end . 75) (:start . 60) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Gfrc") (:form . "Gfrc") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Geobacter") (:form . "Geobacter") (:end . 92)\n  (:start . 83) (:id . 59))\n ((:tag . "NNP") (:stem . "sp.") (:form . "sp.") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "FRC-32") (:form . "FRC-32") (:end . 103)\n  (:start . 97) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Dace") (:form . "Dace") (:end . 109) (:start . 105)\n  (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Desulfuromonas") (:form . "Desulfuromonas")\n  (:end . 125) (:start . 111) (:id . 65))\n ((:tag . "NNS") (:stem . "acetoxidan") (:form . "acetoxidans") (:end . 137)\n  (:start . 126) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Dpro") (:form . "Dpro") (:end . 143) (:start . 139)\n  (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 144) (:start . 143)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Delta") (:form . "Delta") (:end . 150)\n  (:start . 145) (:id . 70))\n ((:tag . "NN") (:stem . "proteobacterium") (:form . "proteobacterium")\n  (:end . 166) (:start . 151) (:id . 71))\n ((:tag . "NN") (:stem . "mlms-1") (:form . "MLMS-1") (:end . 173)\n  (:start . 167) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1.162) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100162@unknown@formal@none@1@S@(b) Hypothetical proteins from Geobacter species.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "b") (:form . "b") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "Hypothetical") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Geobacter") (:form . "Geobacter") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.163) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100163@unknown@formal@none@1@S@The inframe stop codons (TAG) are shown in red.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TAG") (:form . "TAG") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "red") (:form . "red") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.164) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100164@unknown@formal@none@1@S@This cluster is probably an artifact of close phylogenetic relationship.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "artifact") (:form . "artifact") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 58)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x1.165.1) (:span 16 24)))\n (:hscopes ((:id . :x1.165.1) (:span 16 71)))\n (:identifiers (:sid . :s1.165) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100165@unknown@formal@none@1@S@We expect that this cluster may represent a novel selenoprotein family.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "expect") (:form . "expect") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 63) (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x1.166.1) (:span 28 31)) ((:id . :x1.166.2) (:span 3 9)))\n (:hscopes ((:id . :x1.166.1) (:span 28 70)) ((:id . :x1.166.2) (:span 3 70)))\n (:identifiers (:sid . :s1.166) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100166@unknown@formal@none@1@S@This is because the inframe stop codons of these proteins are exclusively TGA, and all of the above organisms possess selenocysteine insertion machinery (data not shown).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 73)\n  (:start . 62) (:id . 53))\n ((:tag . "NNP") (:stem . "TGA") (:form . "TGA") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 109)\n  (:start . 100) (:id . 61))\n ((:tag . "VBP") (:stem . "possess") (:form . "possess") (:end . 117)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 132) (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 158)\n  (:start . 154) (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x1.167.1) (:span 159 162)))\n (:nscopes ((:id . :x1.167.1) (:span 153 169)))\n (:identifiers (:sid . :s1.167) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100167@unknown@formal@none@1@S@High conservation of residues near the inframe stop codon also suggests the importance of this region.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1.168.1) (:span 63 71)))\n (:hscopes ((:id . :x1.168.1) (:span 63 101)))\n (:identifiers (:sid . :s1.168) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100168@unknown@formal@none@1@S@If they are true selenoproteins, this protein family becomes a rare instance of selenoprotein that lacks non-selenocysteine homologs.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 31) (:start . 17) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "lack") (:form . "lacks") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-selenocysteine") (:form . "non-selenocysteine")\n  (:end . 123) (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1.169.1) (:span 99 104)))\n (:nscopes ((:id . :x1.169.1) (:span 99 132)))\n (:identifiers (:sid . :s1.169) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100170@unknown@formal@none@1@S@Therefore, yet another possibility is that they are a highly conserved operon.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "yet") (:form . "yet") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "operon") (:form . "operon") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x1.171.1) (:span 23 34)))\n (:hscopes ((:id . :x1.171.1) (:span 23 77)))\n (:identifiers (:sid . :s1.171) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100171@unknown@formal@none@1@S@An experimental verification is necessary to distinguish these two possibilities.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "verification") (:form . "verification") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "VB") (:stem . "distinguish") (:form . "distinguish") (:end . 56)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 62) (:start . 57)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "possibility") (:form . "possibilities") (:end . 80)\n  (:start . 67) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.172) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100172@unknown@formal@none@1@S@The second cluster consists of two hypothetical proteins, again from G. sulfurreducens and G. metallireducens (Figure 4b).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "sulfurreducens") (:form . "sulfurreducens")\n  (:end . 86) (:start . 72) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "metallireducen") (:form . "metallireducens")\n  (:end . 109) (:start . 94) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "NNP") (:stem . "4b") (:form . "4b") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.173) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100173@unknown@formal@none@1@S@In contrast to the first cluster, no homolog was identified from other species.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1.174.1) (:span 34 36)))\n (:nscopes ((:id . :x1.174.1) (:span 34 78)))\n (:identifiers (:sid . :s1.174) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100174@unknown@formal@none@1@S@This cluster is probably a false positive and not readthrough proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "readthrough") (:form . "readthrough") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x1.175.2) (:span 16 24)))\n (:ncues ((:id . :x1.175.1) (:span 46 49)))\n (:hscopes ((:id . :x1.175.2) (:span 16 70)))\n (:nscopes ((:id . :x1.175.1) (:span 46 70)))\n (:identifiers (:sid . :s1.175) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100175@unknown@formal@none@1@S@This is because the residues near the inframe stop codons are poorly conserved.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "near") (:form . "near") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.176) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100176@unknown@formal@none@1@S@Moreover, the C-terminal extensions are quite short (about 20 aa).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "extension") (:form . "extensions") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.177) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100177@unknown@formal@none@1@S@The sequence conservation in this region can be easily explained by the close phylogenetic relationship between the two species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "easily") (:form . "easily") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 90)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 103)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.178) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100178@unknown@formal@none@1@S@In summary, although a possible selenoprotein was newly identified, there was no promising candidate for an unknown amino acid encoded by a stop codon.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "promising") (:form . "promising") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 126) (:start . 122)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x1.179.1) (:span 78 80)))\n (:nscopes ((:id . :x1.179.1) (:span 78 150)))\n (:identifiers (:sid . :s1.179) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100180@unknown@formal@none@1@S@The above negative result could be explained if the filtering process, which is the final step of the prediction method (Figure 2), was too strict.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "filter") (:form . "filtering") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 112)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 119)\n  (:start . 113) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 135) (:start . 132)\n  (:id . 68))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "strict") (:form . "strict") (:end . 146)\n  (:start . 140) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1.181.1) (:span 26 31)))\n (:hscopes ((:id . :x1.181.1) (:span 0 146)))\n (:identifiers (:sid . :s1.181) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100181@unknown@formal@none@1@S@Although the raw output of the search for evolutionarily conserved iORFs was 273 clusters, most of them were discarded at the subsequent filtering stage.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "raw") (:form . "raw") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 56) (:start . 42) (:id . 50))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "273") (:form . "273") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 136)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "filtering") (:form . "filtering") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s1.182) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100182@unknown@formal@none@1@S@Because we have no a priori knowledge about the 23rd amino acid, cutoff thresholds for the filtering procedures were determined based on the known readthrough proteins.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "FW") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "FW") (:stem . "priori") (:form . "priori") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cutoff") (:form . "cutoff") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "NNS") (:stem . "threshold") (:form . "thresholds") (:end . 82)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "filter") (:form . "filtering") (:end . 100)\n  (:start . 91) (:id . 59))\n ((:tag . "NNS") (:stem . "procedure") (:form . "procedures") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 146)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 158)\n  (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x1.183.1) (:span 16 18)))\n (:nscopes ((:id . :x1.183.1) (:span 16 63)))\n (:identifiers (:sid . :s1.183) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100183@unknown@formal@none@1@S@This is practically indispensable for objective classification of candidates, but there is no guarantee that unknown proteins with the 23rd amino acid will score higher than the thresholds.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "practically") (:form . "practically") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "indispensable") (:form . "indispensable")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "classification") (:form . "classification")\n  (:end . 62) (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 76)\n  (:start . 66) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 87) (:start . 82)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "guarantee") (:form . "guarantee") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 125)\n  (:start . 117) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "VB") (:stem . "score") (:form . "score") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 168)\n  (:start . 162) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "threshold") (:form . "thresholds") (:end . 188)\n  (:start . 178) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1.184.1) (:span 91 103)))\n (:hscopes ((:id . :x1.184.1) (:span 91 188)))\n (:identifiers (:sid . :s1.184) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100184@unknown@formal@none@1@S@To explore whether a number of good candidates lie below the thresholds, the 273 clusters were analyzed in a way independent from filtering.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "VBP") (:stem . "lie") (:form . "lie") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "threshold") (:form . "thresholds") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "CD") (:stem . "273") (:form . "273") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 103)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 124)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "filter") (:form . "filtering") (:end . 139)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x1.185.1) (:span 11 18)))\n (:hscopes ((:id . :x1.185.1) (:span 11 71)))\n (:identifiers (:sid . :s1.185) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100185@unknown@formal@none@1@S@If an organism has many readthrough proteins, proteins from the organism will frequently appear in the 273 clusters.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 88)\n  (:start . 78) (:id . 55))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "273") (:form . "273") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.186) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100186@unknown@formal@none@1@S@Moreover, relative usage of the inframe stop codons will deviate from that of usual termination signals in the proteome.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "deviate") (:form . "deviate") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "usual") (:form . "usual") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "termination") (:form . "termination") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.187) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100187@unknown@formal@none@1@S@Figure 5 shows the discrepancies between relative usage of the inframe and C-terminal stop codons of 127 organisms in the pre-filtering clusters.@(((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "discrepancy") (:form . "discrepancies") (:end . 32)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "CD") (:stem . "127") (:form . "127") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pre-filtering") (:form . "pre-filtering")\n  (:end . 135) (:start . 122) (:id . 62))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 144)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1.188) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100188@unknown@formal@none@1@S@Only seven organisms had statistically significant discrepancies (P < 0.05), and all of them are known to utilize selenocysteine or pyrrolysine.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "discrepancy") (:form . "discrepancies") (:end . 64)\n  (:start . 51) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 49))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "VB") (:stem . "utilize") (:form . "utilize") (:end . 113)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 128) (:start . 114) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 143)\n  (:start . 132) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1.189) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100190@unknown@formal@none@1@S@Discrepancies of stop codon usages between the inframe and C-terminal stop codons.@(((:tag . "NNS") (:stem . "discrepancy") (:form . "Discrepancies") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "usage") (:form . "usages") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.191) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100191@unknown@formal@none@1@S@The inframe stop codon usage is taken from the pre-filtering clusters, and the C-terminal usage is computed based on the annotated proteins of the organism.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pre-filtering") (:form . "pre-filtering")\n  (:end . 60) (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "annotated") (:form . "annotated") (:end . 130)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 155)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1.192) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100192@unknown@formal@none@1@S@Red circle: an organism with pyrrolysine, blue; selenocysteine, yellow; both pyrrolysine and selenocysteine, white; neither pyrrolysine nor selenocysteine.@(((:tag . "JJ") (:stem . "red") (:form . "Red") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "circle") (:form . "circle") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 62) (:start . 48) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 88)\n  (:start . 77) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 107) (:start . 93) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "CC") (:stem . "nor") (:form . "nor") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 154) (:start . 140) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1.193.1) (:span 116 123 136 139)))\n (:nscopes ((:id . :x1.193.1) (:span 116 154)))\n (:identifiers (:sid . :s1.193) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100193@unknown@formal@none@1@S@The organisms are ordered by their discrepancy scores.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "order") (:form . "ordered") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 34)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "discrepancy") (:form . "discrepancy") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.194) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100194@unknown@formal@none@1@S@The discrepancy score is the negative logarithm of a p-value of Fisher's exact test.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "discrepancy") (:form . "discrepancy") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "logarithm") (:form . "logarithm") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "p-value") (:form . "p-value") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Fisher") (:form . "Fisher") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.195) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100195@unknown@formal@none@1@S@The dotted line indicates significance level 0.05 after a correction for multiple testing.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "dot") (:form . "dotted") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "CD") (:stem . "0.05") (:form . "0.05") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.196) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100196@unknown@formal@none@1@S@When top ten organisms were examined, only Gluconobacter oxydans was an organism not known to have stop-codon-encoded amino acids.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Gluconobacter") (:form . "Gluconobacter")\n  (:end . 56) (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "oxydan") (:form . "oxydans") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "stop-codon-encode") (:form . "stop-codon-encoded")\n  (:end . 117) (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 129)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x1.197.1) (:span 81 84)))\n (:nscopes ((:id . :x1.197.1) (:span 81 129)))\n (:identifiers (:sid . :s1.197) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100197@unknown@formal@none@1@S@An inspection of the G. oxydans iORFs in the 273 clusters revealed that their inframe stop codons are dominated by TAA, but all of them belong to a single protein cluster associated with transposable elements.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inspection") (:form . "inspection") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "G.") (:form . "G.") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "oxydan") (:form . "oxydans") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "CD") (:stem . "273") (:form . "273") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 77)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "dominate") (:form . "dominated") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TAA") (:form . "TAA") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 142)\n  (:start . 136) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 154)\n  (:start . 148) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 162)\n  (:start . 155) (:id . 72))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 170)\n  (:start . 163) (:id . 73))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 181)\n  (:start . 171) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "transposable") (:form . "transposable") (:end . 199)\n  (:start . 187) (:id . 76))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 208)\n  (:start . 200) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1.198) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100198@unknown@formal@none@1@S@Because it seems unlikely that an insertion system of novel amino acid evolves solely for transposable elements, this organism cannot be considered as a good candidate of the 23rd amino acid.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unlikely") (:form . "unlikely") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "evolve") (:form . "evolves") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "RB") (:stem . "solely") (:form . "solely") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transposable") (:form . "transposable") (:end . 102)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 126)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 147)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 167)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 179) (:start . 175)\n  (:id . 71))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 190) (:start . 186)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x1.199.2) (:span 137 147)) ((:id . :x1.199.3) (:span 17 25))\n  ((:id . :x1.199.4) (:span 11 16)))\n (:ncues ((:id . :x1.199.1) (:span 127 133)))\n (:hscopes ((:id . :x1.199.2) (:span 113 190))\n  ((:id . :x1.199.3) (:span 17 111)) ((:id . :x1.199.4) (:span 11 111)))\n (:nscopes ((:id . :x1.199.1) (:span 113 190)))\n (:identifiers (:sid . :s1.199) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100200@unknown@formal@none@1@S@However, the result agrees with the filtering-dependent analysis that no candidate of the novel stop-codon-encoded amino acid is detectable in the current dataset.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "agree") (:form . "agrees") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "filtering-dependent")\n  (:form . "filtering-dependent") (:end . 55) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 114) (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 125) (:start . 121)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 162)\n  (:start . 155) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1.201.1) (:span 70 72)))\n (:nscopes ((:id . :x1.201.1) (:span 70 162)))\n (:identifiers (:sid . :s1.201) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100201@unknown@formal@none@1@S@Discussion@(((:tag . "NN") (:stem . "discussion") (:form . "Discussion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.202) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5100202@unknown@formal@none@1@S@As the number of completely sequenced genomes increases, several research groups started to predict proteins that contain stop-codon-encoded amino acids through computational analyses.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "VBD") (:stem . "start") (:form . "started") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 140) (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 160)\n  (:start . 153) (:id . 63))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 174) (:start . 161) (:id . 64))\n ((:tag . "NNS") (:stem . "analysis") (:form . "analyses") (:end . 183)\n  (:start . 175) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1.203) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100203@unknown@formal@none@1@S@Most of them are aimed at identification of selenoproteins, reflecting concerns from the scientific community and accumulated knowledge on selenocysteine.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "aim") (:form . "aimed") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 40) (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 58) (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "concern") (:form . "concerns") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "scientific") (:form . "scientific") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "community") (:form . "community") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "accumulate") (:form . "accumulated") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 138) (:start . 136)\n  (:id . 61))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 153) (:start . 139) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.204) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100204@unknown@formal@none@1@S@In order to improve prediction specificity, they have fully exploited the known features of selenocysteine, such as the SECIS elements or cysteine homologs, which have cysteine in place of selenocysteine.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "improve") (:form . "improve") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "exploit") (:form . "exploited") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 106) (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SECIS") (:form . "SECIS") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 155)\n  (:start . 147) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 176)\n  (:start . 168) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 185)\n  (:start . 180) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 203) (:start . 189) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1.205) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100205@unknown@formal@none@1@S@However, since the target of this study is the 23rd amino acid, and there is no a priori knowledge, only general properties of stop-codon-encoded amino acids can be used for prediction.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 57) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 79) (:start . 77)\n  (:id . 59))\n ((:tag . "FW") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 60))\n ((:tag . "FW") (:stem . "priori") (:form . "priori") (:end . 88)\n  (:start . 82) (:id . 61))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 98)\n  (:start . 89) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 63))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 104) (:start . 100)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 112)\n  (:start . 105) (:id . 65))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 123)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 145) (:start . 127) (:id . 68))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 157)\n  (:start . 152) (:id . 70))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 161) (:start . 158)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 169) (:start . 165)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 173) (:start . 170)\n  (:id . 74))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 184)\n  (:start . 174) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x1.206.1) (:span 77 79)))\n (:nscopes ((:id . :x1.206.1) (:span 77 98)))\n (:identifiers (:sid . :s1.206) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100206@unknown@formal@none@1@S@Such general-purpose algorithms have also been developed to date.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "general-purpose") (:form . "general-purpose")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 31)\n  (:start . 21) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 56)\n  (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1.207) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100207@unknown@formal@none@1@S@The method of Chaudhuri and Yeates 10 extracts iORFs from microbial genomes and analyzes sequence conservation around the inframe stop codon.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Chaudhuri") (:form . "Chaudhuri") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Yeates") (:form . "Yeates") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "analyze") (:form . "analyzes") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 110)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 129)\n  (:start . 122) (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.208) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100208@unknown@formal@none@1@S@Their method is thus similar to ours and applicable to both selenocysteine and pyrrolysine.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "our") (:form . "ours") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "applicable") (:form . "applicable") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 74) (:start . 60) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.209) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100210@unknown@formal@none@1@S@Their method is applicable not only to stop codon readthrough but also to frameshift.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "applicable") (:form . "applicable") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VB") (:stem . "stop") (:form . "stop") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "readthrough") (:form . "readthrough") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "frameshift") (:form . "frameshift") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.211) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100211@unknown@formal@none@1@S@However, both of them did not apply their methods to search for novel amino acids.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "VB") (:stem . "apply") (:form . "apply") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 41)\n  (:start . 36) (:id . 50))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "VB") (:stem . "search") (:form . "search") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 81) (:start . 76)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1.212.1) (:span 26 29)))\n (:nscopes ((:id . :x1.212.1) (:span 26 81)))\n (:identifiers (:sid . :s1.212) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100212@unknown@formal@none@1@S@Therefore, the question of the 23rd amino acid has not been investigated from the viewpoint of coding sequences.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 72)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "viewpoint") (:form . "viewpoint") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 101) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1.213.1) (:span 51 54)))\n (:nscopes ((:id . :x1.213.1) (:span 11 111)))\n (:identifiers (:sid . :s1.213) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100213@unknown@formal@none@1@S@Additionally, the previous methods cannot effectively discriminate pseudogenes from readthrough genes.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "RB") (:stem . "effectively") (:form . "effectively") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "VB") (:stem . "discriminate") (:form . "discriminate") (:end . 66)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 78)\n  (:start . 67) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 95)\n  (:start . 84) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 101) (:start . 96)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x1.214.1) (:span 35 41)))\n (:nscopes ((:id . :x1.214.1) (:span 35 101)))\n (:identifiers (:sid . :s1.214) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100214@unknown@formal@none@1@S@For instance, Chaudhuri and Yeates reported a homolog of cobalamin biosynthesis protein CobN as a novel candidate of pyrrolysine protein.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Chaudhuri") (:form . "Chaudhuri") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Yeates") (:form . "Yeates") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "report") (:form . "reported") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cobalamin") (:form . "cobalamin") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "biosynthesis") (:form . "biosynthesis") (:end . 79)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "cobn") (:form . "CobN") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 128)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.215) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100215@unknown@formal@none@1@S@However, the gene is probably a pseudogene because it contains an inframe TAA codon in addition to the TAG codon, and only one species seems to have the amber-containing form of the gene.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pseudogene") (:form . "pseudogene") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "NNP") (:stem . "TAA") (:form . "TAA") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "TAG") (:form . "TAG") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 122) (:start . 118)\n  (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 134)\n  (:start . 127) (:id . 67))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 69))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 148) (:start . 144)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "amber-containing") (:form . "amber-containing")\n  (:end . 169) (:start . 153) (:id . 72))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 186) (:start . 182)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x1.216.1) (:span 135 140))\n  ((:id . :x1.216.2) (:span 21 29)))\n (:hscopes ((:id . :x1.216.1) (:span 123 186))\n  ((:id . :x1.216.2) (:span 21 42)))\n (:identifiers (:sid . :s1.216) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100216@unknown@formal@none@1@S@The previous methods also assume that proteins with stop-codon-encoded amino acids will have non-readthrough homologs (i.e., homologous proteins that do not have inframe stop codons).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "assume") (:form . "assume") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 70) (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 87) (:start . 83)\n  (:id . 53))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 92) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 108) (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 117)\n  (:start . 109) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 57))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 123) (:start . 119)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 135)\n  (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 156) (:start . 153)\n  (:id . 64))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 169)\n  (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 174) (:start . 170)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 181)\n  (:start . 175) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x1.217.2) (:span 26 32)))\n (:ncues ((:id . :x1.217.1) (:span 153 156)))\n (:hscopes ((:id . :x1.217.2) (:span 26 182)))\n (:nscopes ((:id . :x1.217.1) (:span 153 182)))\n (:identifiers (:sid . :s1.217) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100217@unknown@formal@none@1@S@However, that is not necessarily true.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 32)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1.218) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100218@unknown@formal@none@1@S@For example, pyrrolysine-containing monomethylamine methyltransferases adopt TIM barrel fold 6, but their primary sequences do not exhibit detectable similarity to other TIM barrel proteins because of evolutionary divergence.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pyrrolysine-containing")\n  (:form . "pyrrolysine-containing") (:end . 35) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "monomethylamine") (:form . "monomethylamine")\n  (:end . 51) (:start . 36) (:id . 46))\n ((:tag . "NNS") (:stem . "methyltransferas") (:form . "methyltransferases")\n  (:end . 70) (:start . 52) (:id . 47))\n ((:tag . "VBP") (:stem . "adopt") (:form . "adopt") (:end . 76) (:start . 71)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TIM") (:form . "TIM") (:end . 80) (:start . 77)\n  (:id . 49))\n ((:tag . "NN") (:stem . "barrel") (:form . "barrel") (:end . 87)\n  (:start . 81) (:id . 50))\n ((:tag . "RB") (:stem . "fold") (:form . "fold") (:end . 92) (:start . 88)\n  (:id . 51))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 94) (:start . 93)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 99) (:start . 96)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 105)\n  (:start . 100) (:id . 55))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 113)\n  (:start . 106) (:id . 56))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 123)\n  (:start . 114) (:id . 57))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 126) (:start . 124)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "VB") (:stem . "exhibit") (:form . "exhibit") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 149)\n  (:start . 139) (:id . 61))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 160)\n  (:start . 150) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 169)\n  (:start . 164) (:id . 64))\n ((:tag . "NNP") (:stem . "TIM") (:form . "TIM") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "barrel") (:form . "barrel") (:end . 180)\n  (:start . 174) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 189)\n  (:start . 181) (:id . 67))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 197)\n  (:start . 190) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 213)\n  (:start . 201) (:id . 70))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 224)\n  (:start . 214) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x1.219.1) (:span 127 130)))\n (:nscopes ((:id . :x1.219.1) (:span 127 189)))\n (:identifiers (:sid . :s1.219) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100220@unknown@formal@none@1@S@Yet another example is glycine reductase selenoprotein A.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "glycine") (:form . "glycine") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "reductase") (:form . "reductase") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 54) (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 56) (:start . 55)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.221) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100221@unknown@formal@none@1@S@Only the selenocysteine-containing form of the enzyme is currently known 20.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "selenocysteine-containing")\n  (:form . "selenocysteine-containing") (:end . 34) (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 39) (:start . 35)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.222) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100222@unknown@formal@none@1@S@Therefore, it is important not to assume non-readthrough homologs for exploring novel candidates.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "assume") (:form . "assume") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 56) (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "explore") (:form . "exploring") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "candidate") (:form . "candidates") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1.223.1) (:span 27 30)))\n (:nscopes ((:id . :x1.223.1) (:span 27 96)))\n (:identifiers (:sid . :s1.223) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100223@unknown@formal@none@1@S@If any non-readthrough homologs are registered in public sequence databases, a careful annotation process of a newly sequenced genome will be able to detect readthrough genes, even though they may be annotated as pseudogenes.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 22) (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "register") (:form . "registered") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "public") (:form . "public") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "careful") (:form . "careful") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "annotation") (:form . "annotation") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "RB") (:stem . "newly") (:form . "newly") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 168)\n  (:start . 157) (:id . 67))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 174)\n  (:start . 169) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 180) (:start . 176)\n  (:id . 70))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 192) (:start . 188)\n  (:id . 72))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 212) (:start . 210)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 224)\n  (:start . 213) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x1.224.1) (:span 193 196)))\n (:hscopes ((:id . :x1.224.1) (:span 188 224)))\n (:identifiers (:sid . :s1.224) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100224@unknown@formal@none@1@S@However, if all members of a gene family have stop codon readthrough, correct annotation of their gene structure will be extremely difficult, and all of them will be split into two distinct genes.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 40)\n  (:start . 34) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 50) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 68)\n  (:start . 57) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "annotation") (:form . "annotation") (:end . 88)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 97)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 102) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 112)\n  (:start . 103) (:id . 61))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 130)\n  (:start . 121) (:id . 64))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 69))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "split") (:form . "split") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 176) (:start . 172)\n  (:id . 74))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 180) (:start . 177)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 189)\n  (:start . 181) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 195)\n  (:start . 190) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1.225) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100225@unknown@formal@none@1@S@The method reported here is unique in that it does not assume non-readthrough homologs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "VB") (:stem . "assume") (:form . "assume") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 77) (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1.226.1) (:span 51 54)))\n (:nscopes ((:id . :x1.226.1) (:span 51 86)))\n (:identifiers (:sid . :s1.226) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100226@unknown@formal@none@1@S@Using this method, a systematic screening of the 23rd amino acid and other readthrough genes was carried out.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "systematic") (:form . "systematic") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "NN") (:stem . "screening") (:form . "screening") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 86)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.227) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100227@unknown@formal@none@1@S@Many of the currently known selenoproteins and pyrrolysine proteins were recovered, indicating the effectiveness of this approach.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 42) (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pyrrolysine") (:form . "pyrrolysine") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 94)\n  (:start . 84) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "effectiveness") (:form . "effectiveness")\n  (:end . 112) (:start . 99) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.228) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100228@unknown@formal@none@1@S@In particular, successful detection of pyrrolysine-containing methyltransferases and selenoprotein A should be noted.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pyrrolysine-containing")\n  (:form . "pyrrolysine-containing") (:end . 61) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "methyltransferas") (:form . "methyltransferases")\n  (:end . 80) (:start . 62) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 50))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 98) (:start . 85) (:id . 51))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 100) (:start . 99)\n  (:id . 52))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 107)\n  (:start . 101) (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 110) (:start . 108)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 116)\n  (:start . 111) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.229) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100230@unknown@formal@none@1@S@What can be concluded from this result?@(((:tag . "WP") (:stem . "what") (:form . "What") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 39) (:start . 38)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1.231) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100231@unknown@formal@none@1@S@The most likely explanation is that the 23rd amino acid does not exist, or its distribution on the tree of life is rather limited.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "VB") (:stem . "exist") (:form . "exist") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 91)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "tree") (:form . "tree") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 111) (:start . 107)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 121)\n  (:start . 115) (:id . 65))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 129)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x1.232.2) (:span 72 74)) ((:id . :x1.232.3) (:span 9 15)))\n (:ncues ((:id . :x1.232.1) (:span 61 64)))\n (:hscopes ((:id . :x1.232.2) (:span 36 129))\n  ((:id . :x1.232.3) (:span 9 27)))\n (:nscopes ((:id . :x1.232.1) (:span 61 70)))\n (:identifiers (:sid . :s1.232) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100232@unknown@formal@none@1@S@Although a broad spectrum of taxonomic groups has been subjected to genome sequencing, the genomes of most microbial species on the earth have yet to be determined.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "broad") (:form . "broad") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "spectrum") (:form . "spectrum") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "taxonomic") (:form . "taxonomic") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "earth") (:form . "earth") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 163)\n  (:start . 153) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1.233) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100233@unknown@formal@none@1@S@The unknown amino acid may be used by these species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x1.234.1) (:span 23 26)))\n (:hscopes ((:id . :x1.234.1) (:span 0 51)))\n (:identifiers (:sid . :s1.234) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100234@unknown@formal@none@1@S@Alternatively, only one organism in our dataset may have the 23rd amino acid.@(((:tag . "RB") (:stem . "alternatively") (:form . "Alternatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x1.235.1) (:span 48 51)))\n (:hscopes ((:id . :x1.235.1) (:span 48 76)))\n (:identifiers (:sid . :s1.235) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100235@unknown@formal@none@1@S@This is because our method is limited to readthrough genes conserved across two or more species.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "readthrough") (:form . "readthrough") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.236) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100236@unknown@formal@none@1@S@If the novel amino acid appears in younger, non-conserved sequences, our technique will miss them.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "young") (:form . "younger") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "non-conserved") (:form . "non-conserved")\n  (:end . 57) (:start . 44) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "VB") (:stem . "miss") (:form . "miss") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1.237) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100237@unknown@formal@none@1@S@In either case, the distribution of the 23rd amino acid will be significantly narrower than that of selenocysteine, which has scattered but wide distribution 21.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 32)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 77) (:start . 64) (:id . 55))\n ((:tag . "JJR") (:stem . "narrow") (:form . "narrower") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 114) (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "scatter") (:form . "scattered") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 157)\n  (:start . 145) (:id . 67))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.238) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100238@unknown@formal@none@1@S@This conclusion coincides with and strengthens that of the previous research on tRNA 14.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "coincide") (:form . "coincides") (:end . 25)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "strengthen") (:form . "strengthens") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "tRNA") (:form . "tRNA") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.239) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100240@unknown@formal@none@1@S@It is well known that the genetic code varies in several organisms 22.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "vary") (:form . "varies") (:end . 45) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.241) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100241@unknown@formal@none@1@S@Thus, certain organisms may use one of the sense codons for the novel amino acid.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 69) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 75) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1.242.1) (:span 24 27)))\n (:hscopes ((:id . :x1.242.1) (:span 24 80)))\n (:identifiers (:sid . :s1.242) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100242@unknown@formal@none@1@S@Because codons for most amino acids are degenerate, redefinition of one of them is feasible.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 14) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "redefinition") (:form . "redefinition") (:end . 64)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "feasible") (:form . "feasible") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x1.243.1) (:span 83 91)))\n (:hscopes ((:id . :x1.243.1) (:span 68 91)))\n (:identifiers (:sid . :s1.243) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100243@unknown@formal@none@1@S@However, that possibility is beyond the scope of this study and is left as an open problem.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "beyond") (:form . "beyond") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "scope") (:form . "scope") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "leave") (:form . "left") (:end . 71) (:start . 67)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 82) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.244) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100244@unknown@formal@none@1@S@Bioinformatics analysis of unusual tRNA genes and codon usage may provide insights into this problem.@(((:tag . "NNP") (:stem . "Bioinformatic") (:form . "Bioinformatics")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "NN") (:stem . "trna") (:form . "tRNA") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x1.245.1) (:span 62 65)))\n (:hscopes ((:id . :x1.245.1) (:span 62 100)))\n (:identifiers (:sid . :s1.245) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100245@unknown@formal@none@1@S@In addition to the 23rd amino acid, our method can simultaneously explore selenoproteins and other readthrough proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 46)\n  (:start . 40) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 65) (:start . 51) (:id . 53))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 88) (:start . 74) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.246) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100246@unknown@formal@none@1@S@A common assumption in microbial selenoprotein predictions is that selenoproteins will have cysteine homologs.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 46) (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 58)\n  (:start . 47) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 81) (:start . 67) (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 86) (:start . 82)\n  (:id . 52))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 100)\n  (:start . 92) (:id . 54))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 109)\n  (:start . 101) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x1.247.1) (:span 9 19)))\n (:hscopes ((:id . :x1.247.1) (:span 9 109)))\n (:identifiers (:sid . :s1.247) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100247@unknown@formal@none@1@S@Zhang et al. 20 examined the validity of this assumption using a SECIS-based method and concluded that selenoproteins without cysteine homologs will be extremely rare.@(((:tag . "NNP") (:stem . "Zhang") (:form . "Zhang") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "validity") (:form . "validity") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 56)\n  (:start . 46) (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "secis-based") (:form . "SECIS-based") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "conclude") (:form . "concluded") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 117) (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 143)\n  (:start . 135) (:id . 62))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1.248.1) (:span 118 125)))\n (:nscopes ((:id . :x1.248.1) (:span 118 143)))\n (:identifiers (:sid . :s1.248) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100248@unknown@formal@none@1@S@Our method can reassess this assumption in a SECIS-independent way.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "reassess") (:form . "reassess") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "secis-independent") (:form . "SECIS-independent")\n  (:end . 62) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.249) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100250@unknown@formal@none@1@S@Therefore, selenoproteins that lack cysteine homologs will be scarce, as previously reported.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "selenoprotein") (:form . "selenoproteins")\n  (:end . 25) (:start . 11) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "lack") (:form . "lack") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 58) (:start . 54)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "scarce") (:form . "scarce") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x1.251.1) (:span 31 35)))\n (:nscopes ((:id . :x1.251.1) (:span 31 53)))\n (:identifiers (:sid . :s1.251) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100251@unknown@formal@none@1@S@Other readthrough proteins with canonical amino acids (i.e., proteins that have canonical amino acids at their inframe stop codons) are quite rare in prokaryotes 1.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 118)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "JJ") (:stem . "rare") (:form . "rare") (:end . 146) (:start . 142)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 161)\n  (:start . 150) (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1.252) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100252@unknown@formal@none@1@S@The result reported here is in agreement, but it is not conclusive.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "conclusive") (:form . "conclusive") (:end . 66)\n  (:start . 56) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x1.253.1) (:span 52 55)))\n (:nscopes ((:id . :x1.253.1) (:span 52 66)))\n (:identifiers (:sid . :s1.253) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100253@unknown@formal@none@1@S@This is because our method assumes that stop-codon-encoded amino acid is located inside a domain, but it is unclear whether it holds true in prokaryotic readthrough with canonical amino acids.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "assume") (:form . "assumes") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 58) (:start . 40) (:id . 49))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "inside") (:form . "inside") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "hold") (:form . "holds") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 152)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 164)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 185)\n  (:start . 180) (:id . 71))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 191)\n  (:start . 186) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x1.254.1) (:span 116 123))\n  ((:id . :x1.254.2) (:span 108 115)) ((:id . :x1.254.3) (:span 27 34)))\n (:hscopes ((:id . :x1.254.1) (:span 116 191))\n  ((:id . :x1.254.2) (:span 108 191)) ((:id . :x1.254.3) (:span 27 96)))\n (:identifiers (:sid . :s1.254) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100254@unknown@formal@none@1@S@At least, only one experimentally-confirmed example from a pathogenic strain of Escherichia coli 23, whose genome is not yet determined, does not obey this rule.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "experimentally-confirmed")\n  (:form . "experimentally-confirmed") (:end . 43) (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "pathogenic") (:form . "pathogenic") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "FW") (:stem . "escherichia") (:form . "Escherichia") (:end . 91)\n  (:start . 80) (:id . 54))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 113)\n  (:start . 107) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 145) (:start . 142)\n  (:id . 66))\n ((:tag . "VB") (:stem . "obey") (:form . "obey") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x1.255.1) (:span 142 145))\n  ((:id . :x1.255.2) (:span 117 120)))\n (:nscopes ((:id . :x1.255.1) (:span 142 160))\n  ((:id . :x1.255.2) (:span 101 135)))\n (:identifiers (:sid . :s1.255) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100255@unknown@formal@none@1@S@What can be concluded from our result is that this type of readthrough will be located outside of domains, such as a linker between two domains.@(((:tag . "WP") (:stem . "what") (:form . "What") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conclude") (:form . "concluded") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "outside") (:form . "outside") (:end . 94)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "linker") (:form . "linker") (:end . 123)\n  (:start . 117) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 131)\n  (:start . 124) (:id . 66))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 143)\n  (:start . 136) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.256) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100256@unknown@formal@none@1@S@Such a stop codon may behave as a switch that regulates production of short and long isoforms from a single mRNA, as in readthrough genes from viruses 24.@(((:tag . "PDT") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "behave") (:form . "behave") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "switch") (:form . "switch") (:end . 40)\n  (:start . 34) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 55)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "isoform") (:form . "isoforms") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 107)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "mrna") (:form . "mRNA") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 131)\n  (:start . 120) (:id . 66))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 142) (:start . 138)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 150)\n  (:start . 143) (:id . 69))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x1.257.1) (:span 18 21)))\n (:hscopes ((:id . :x1.257.1) (:span 18 150)))\n (:identifiers (:sid . :s1.257) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100257@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.258) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5100258@unknown@formal@none@1@S@To explore the possibility of a 23rd amino acid, ORFs in prokaryotic genomes were investigated in a comprehensive way.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "23rd") (:form . "23rd") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "orf") (:form . "ORFs") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 68)\n  (:start . 57) (:id . 54))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 94)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "comprehensive") (:form . "comprehensive")\n  (:end . 113) (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.259) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100260@unknown@formal@none@1@S@Therefore, if such an amino acid exists, it will have limited distribution in the tree of life.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 48) (:start . 44)\n  (:id . 52))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 61)\n  (:start . 54) (:id . 54))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 74)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tree") (:form . "tree") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.261) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100261@unknown@formal@none@1@S@Alternatively, it may be encoded by one of the sense codons.@(((:tag . "RB") (:stem . "alternatively") (:form . "Alternatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sense") (:form . "sense") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x1.262.1) (:span 18 21)))\n (:hscopes ((:id . :x1.262.1) (:span 15 59)))\n (:identifiers (:sid . :s1.262) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100262@unknown@formal@none@1@S@From the viewpoint of selenoprotein prediction, the sensitivity of our method was lower than an existing method.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "viewpoint") (:form . "viewpoint") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "selenoprotein") (:form . "selenoprotein")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 77)\n  (:start . 71) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 104)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.263) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100263@unknown@formal@none@1@S@However, our method has several unique features.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.264) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100264@unknown@formal@none@1@S@It is applicable to general readthrough genes and rigorously excludes pseudogenes and sequencing errors.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "applicable") (:form . "applicable") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "rigorously") (:form . "rigorously") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "exclude") (:form . "excludes") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 81)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 96)\n  (:start . 86) (:id . 54))\n ((:tag . "NNS") (:stem . "error") (:form . "errors") (:end . 103)\n  (:start . 97) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.265) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100265@unknown@formal@none@1@S@Moreover, it does not assume the occurrence of non-readthrough homologs in the public databases.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "assume") (:form . "assume") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 62) (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "public") (:form . "public") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x1.266.1) (:span 18 21)))\n (:nscopes ((:id . :x1.266.1) (:span 18 95)))\n (:identifiers (:sid . :s1.266) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100266@unknown@formal@none@1@S@It will help in identification of novel readthrough genes from the rapidly expanding collection of complete microbial genomes.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 30) (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "VBG") (:stem . "expand") (:form . "expanding") (:end . 84)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "collection") (:form . "collection") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 107)\n  (:start . 99) (:id . 57))\n ((:tag . "JJ") (:stem . "microbial") (:form . "microbial") (:end . 117)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 125)\n  (:start . 118) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.267) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100267@unknown@formal@none@1@S@Methods@(((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s1.268) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5100268@unknown@formal@none@1@S@Enumeration of iORFs from prokaryotic genomes@(((:tag . "NNP") (:stem . "Enumeration") (:form . "Enumeration") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 45)\n  (:start . 38) (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.269) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100270@unknown@formal@none@1@S@From them, 191 representative organisms were selected by excluding close relatives.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "representative") (:form . "representative")\n  (:end . 29) (:start . 15) (:id . 46))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "JJ") (:stem . "close") (:form . "close") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "relative") (:form . "relatives") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.271) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100271@unknown@formal@none@1@S@The threshold was set to average sequence identity 90% of two house-keeping genes, DNA polymerase III α subunit and alanyl-tRNA synthetase.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "house-keeping") (:form . "house-keeping")\n  (:end . 75) (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "α") (:form . "α") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alanyl-trna") (:form . "alanyl-tRNA") (:end . 127)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "synthetase") (:form . "synthetase") (:end . 138)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.272) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100272@unknown@formal@none@1@S@From these 191 genomes, iORFs longer than 80 codons were enumerated using inhouse software, which is available from the author's web site 26.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 36) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "enumerate") (:form . "enumerated") (:end . 67)\n  (:start . 57) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inhouse") (:form . "inhouse") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "software") (:form . "software") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 110)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "author") (:form . "author") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "web") (:form . "web") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 137) (:start . 133)\n  (:id . 66))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1.273) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100273@unknown@formal@none@1@S@Both upstream and downstream regions of its inframe stop codon were required to be longer than 10 codons.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "long") (:form . "longer") (:end . 89) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.274) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100274@unknown@formal@none@1@S@Two stop codons of an iORF (i.e. the inframe and C-terminal stops) can be any combination of canonical stop codons (TAA, TAG, TGA).@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 44)\n  (:start . 37) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 59)\n  (:start . 49) (:id . 53))\n ((:tag . "NNS") (:stem . "stop") (:form . "stops") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 89)\n  (:start . 78) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "canonical") (:form . "canonical") (:end . 102)\n  (:start . 93) (:id . 61))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 114)\n  (:start . 108) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "TAA") (:form . "TAA") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TAG") (:form . "TAG") (:end . 124) (:start . 121)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TGA") (:form . "TGA") (:end . 129) (:start . 126)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 130) (:start . 129)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s1.275) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100275@unknown@formal@none@1@S@However, for Mycoplasma, only TAA and TAG were used.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Mycoplasma") (:form . "Mycoplasma") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TAA") (:form . "TAA") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TAG") (:form . "TAG") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 51) (:start . 47)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s1.276) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100276@unknown@formal@none@1@S@Three codons ATG, TTG and GTG were allowed to be start signals.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ATG") (:form . "ATG") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "TTG") (:form . "TTG") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GTG") (:form . "GTG") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "allow") (:form . "allowed") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "start") (:form . "start") (:end . 54) (:start . 49)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 62)\n  (:start . 55) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s1.277) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100277@unknown@formal@none@1@S@The iORFs of each organism were compared with protein-coding genes of the organism using BLASTX.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "protein-coding") (:form . "protein-coding")\n  (:end . 60) (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BLASTX") (:form . "BLASTX") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.278) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100278@unknown@formal@none@1@S@If an iORF matched any protein-coding genes (E-value < 10-3) and their reading frames did not coincide, the iORF was discarded.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "match") (:form . "matched") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "protein-coding") (:form . "protein-coding")\n  (:end . 37) (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "10-3") (:form . "10-3") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 70)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "VB") (:stem . "coincide") (:form . "coincide") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 126)\n  (:start . 117) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x1.279.1) (:span 90 93)))\n (:nscopes ((:id . :x1.279.1) (:span 90 102)))\n (:identifiers (:sid . :s1.279) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100280@unknown@formal@none@1@S@Remaining iORFs were translated into amino acid sequences.@(((:tag . "VBG") (:stem . "remain") (:form . "Remaining") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.281) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100281@unknown@formal@none@1@S@We translated all three types of nonsense codons into the one-letter code U, so as to simplify visual inspection of sequence alignments.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "translate") (:form . "translated") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nonsense") (:form . "nonsense") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "one-letter") (:form . "one-letter") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 58))\n ((:tag . "VB") (:stem . "simplify") (:form . "simplify") (:end . 94)\n  (:start . 86) (:id . 59))\n ((:tag . "JJ") (:stem . "visual") (:form . "visual") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "inspection") (:form . "inspection") (:end . 112)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 135)\n  (:start . 125) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.282) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100282@unknown@formal@none@1@S@Although the code U is usually for selenocysteine, it will be harmless because U is automatically converted into × inside the BLAST programs.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "selenocysteine") (:form . "selenocysteine")\n  (:end . 49) (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "harmless") (:form . "harmless") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "RB") (:stem . "automatically") (:form . "automatically")\n  (:end . 97) (:start . 84) (:id . 58))\n ((:tag . "VBN") (:stem . "convert") (:form . "converted") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "×") (:form . "×") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "IN") (:stem . "inside") (:form . "inside") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 140)\n  (:start . 132) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s1.283) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100283@unknown@formal@none@1@S@Construction of clusters of conserved iORFs@(((:tag . "NN") (:stem . "construction") (:form . "Construction") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 43) (:start . 38)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.284) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100284@unknown@formal@none@1@S@To examine evolutionary conservation of the iORFs, a window of 101 residues around the inframe stop codon was extracted and subjected to TBLASTN searches against the above 191 genome sequences.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 36)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "window") (:form . "window") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "101") (:form . "101") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 119)\n  (:start . 110) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 133)\n  (:start . 124) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "tblastn") (:form . "TBLASTN") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 175) (:start . 172)\n  (:id . 70))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 182)\n  (:start . 176) (:id . 71))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 192)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s1.285) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100285@unknown@formal@none@1@S@If there were any hits (E-value < 0.01) in other organisms, and if the hit includes 10 upstream and 10 downstream residues of the inframe stop codon, then the iORF was retained.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.01") (:form . "0.01") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 48) (:start . 43)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 58)\n  (:start . 49) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 66) (:start . 64)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hit") (:form . "hit") (:end . 74) (:start . 71)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 83)\n  (:start . 75) (:id . 60))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 86) (:start . 84)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 95)\n  (:start . 87) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 63))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 102) (:start . 100)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 113)\n  (:start . 103) (:id . 65))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 122)\n  (:start . 114) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 68))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 137)\n  (:start . 130) (:id . 69))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 142) (:start . 138)\n  (:id . 70))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 148)\n  (:start . 143) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 72))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 154) (:start . 150)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 74))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 163) (:start . 159)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 167) (:start . 164)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 176)\n  (:start . 168) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s1.286) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100286@unknown@formal@none@1@S@However, if there were any hits (E-value < 10-5) that did not cover the inframe stop codon, the iORF was discarded.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 40)\n  (:start . 33) (:id . 50))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "CD") (:stem . "10-5") (:form . "10-5") (:end . 47) (:start . 43)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 57) (:start . 54)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 61) (:start . 58)\n  (:id . 56))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 67) (:start . 62)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 79)\n  (:start . 72) (:id . 59))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 84) (:start . 80)\n  (:id . 60))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 90) (:start . 85)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 63))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 100) (:start . 96)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 104) (:start . 101)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 114)\n  (:start . 105) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x1.287.1) (:span 58 61)))\n (:nscopes ((:id . :x1.287.1) (:span 58 90)))\n (:identifiers (:sid . :s1.287) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100287@unknown@formal@none@1@S@Eligible iORFs were then clustered using BLASTCLUST with score density 0.5 and minimum length coverage 0.6.@(((:tag . "JJ") (:stem . "eligible") (:form . "Eligible") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "cluster") (:form . "clustered") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "blastclust") (:form . "BLASTCLUST") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 102)\n  (:start . 94) (:id . 56))\n ((:tag . "CD") (:stem . "0.6") (:form . "0.6") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.288) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100288@unknown@formal@none@1@S@After removing singleton clusters, multiple sequence alignments of the remaining clusters were computed using MAFFT 27 with the L-INS-i option.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "remove") (:form . "removing") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "singleton") (:form . "singleton") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 33)\n  (:start . 25) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 63)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 103)\n  (:start . 95) (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 109) (:start . 104)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MAFFT") (:form . "MAFFT") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "L-INS-i") (:form . "L-INS-i") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "NN") (:stem . "option") (:form . "option") (:end . 142)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s1.289) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100290@unknown@formal@none@1@S@If the location or type of stop codons was not identical, the cluster was discarded.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 56)\n  (:start . 47) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 69)\n  (:start . 62) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "discard") (:form . "discarded") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x1.291.1) (:span 43 46)))\n (:nscopes ((:id . :x1.291.1) (:span 43 56)))\n (:identifiers (:sid . :s1.291) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100291@unknown@formal@none@1@S@Three-step filtering of the candidate clusters@(((:tag . "JJ") (:stem . "three-step") (:form . "Three-step") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "filtering") (:form . "filtering") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 46)\n  (:start . 38) (:id . 47)))@@@1@6@((:identifiers (:sid . :s1.292) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100292@unknown@formal@none@1@S@The first filter examines protein-likeliness of the iORFs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "filter") (:form . "filter") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "examine") (:form . "examines") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "protein-likeliness") (:form . "protein-likeliness")\n  (:end . 44) (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s1.293) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100293@unknown@formal@none@1@S@This filter is mainly designed to remove conserved non-coding sequences (CNS) immediately downstream of non-readthrough genes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "filter") (:form . "filter") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "remove") (:form . "remove") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "JJ") (:stem . "non-coding") (:form . "non-coding") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cns") (:form . "CNS") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "non-readthrough") (:form . "non-readthrough")\n  (:end . 119) (:start . 104) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.294) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100294@unknown@formal@none@1@S@If we measure purifying selection for amino acid sequences by the ratio of nonsynonymous to synonymous substitution rates (dN/dS), a protein with a stop-codon-encoded amino acid will indicate the sign of selection, while CNS will not.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "measure") (:form . "measure") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "VBG") (:stem . "purify") (:form . "purifying") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nonsynonymous") (:form . "nonsynonymous")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "synonymous") (:form . "synonymous") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 115)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 121)\n  (:start . 116) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dn/ds") (:form . "dN/dS") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 140)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 166) (:start . 148) (:id . 68))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 177) (:start . 173)\n  (:id . 70))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 182) (:start . 178)\n  (:id . 71))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 191)\n  (:start . 183) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sign") (:form . "sign") (:end . 200) (:start . 196)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 75))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 213)\n  (:start . 204) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 77))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 220)\n  (:start . 215) (:id . 78))\n ((:tag . "NN") (:stem . "cns") (:form . "CNS") (:end . 224) (:start . 221)\n  (:id . 79))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 229) (:start . 225)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 233) (:start . 230)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x1.295.1) (:span 230 233)))\n (:nscopes ((:id . :x1.295.1) (:span 230 233)))\n (:identifiers (:sid . :s1.295) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100295@unknown@formal@none@1@S@The dN/dS was calculated for each of the two parts flanking the inframe stop codon in an iORF using codeml program in the PAML package 28.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dn/ds") (:form . "dN/dS") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 71)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "codeml") (:form . "codeml") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PAML") (:form . "PAML") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "package") (:form . "package") (:end . 134)\n  (:start . 127) (:id . 66))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1.296) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100296@unknown@formal@none@1@S@Statistical significance was estimated by likelihood ratio test 29.@(((:tag . "JJ") (:stem . "statistical") (:form . "Statistical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 38)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 58) (:start . 53)\n  (:id . 48))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 63) (:start . 59)\n  (:id . 49))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s1.297) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100297@unknown@formal@none@1@S@The observed alignment was fitted to two distinct substitution models, one of which estimates dN/dS from the data, and the other fixes it to 1.0.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "fit") (:form . "fitted") (:end . 33) (:start . 27)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "estimate") (:form . "estimates") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "dn/ds") (:form . "dN/dS") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 113)\n  (:start . 109) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "NNS") (:stem . "fix") (:form . "fixes") (:end . 134) (:start . 129)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.298) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100298@unknown@formal@none@1@S@Let lfree and lfix denote log likelihood of these models.@(((:tag . "VB") (:stem . "let") (:form . "Let") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "lfree") (:form . "lfree") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lfix") (:form . "lfix") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "log") (:form . "log") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s1.299) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100300@unknown@formal@none@1@S@If dN/dS was less than 1.0, and the statistics 2Δl was larger than a threshold, we regard it as a sign of purifying selection.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "dn/ds") (:form . "dN/dS") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 46)\n  (:start . 36) (:id . 51))\n ((:tag . "NN") (:stem . "2δl") (:form . "2Δl") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 61)\n  (:start . 55) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 78)\n  (:start . 69) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "regard") (:form . "regard") (:end . 89)\n  (:start . 83) (:id . 60))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sign") (:form . "sign") (:end . 102) (:start . 98)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "purify") (:form . "purifying") (:end . 115)\n  (:start . 106) (:id . 66))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 125)\n  (:start . 116) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s1.301) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100301@unknown@formal@none@1@S@In this study, the threshold was set to 5.0 (corresponds to P < 0.025) so that the known readthrough proteins score higher than the threshold.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "CD") (:stem . "5.0") (:form . "5.0") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 56)\n  (:start . 45) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 63) (:start . 62)\n  (:id . 56))\n ((:tag . "CD") (:stem . "0.025") (:form . "0.025") (:end . 69) (:start . 64)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 58))\n ((:tag . "IN") (:stem . "so") (:form . "so") (:end . 73) (:start . 71)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 88) (:start . 83)\n  (:id . 62))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 100)\n  (:start . 89) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 109)\n  (:start . 101) (:id . 64))\n ((:tag . "VBP") (:stem . "score") (:form . "score") (:end . 115)\n  (:start . 110) (:id . 65))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 122)\n  (:start . 116) (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 127) (:start . 123)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 68))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 141)\n  (:start . 132) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s1.302) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100302@unknown@formal@none@1@S@For each of the above clusters, an all-against-all comparison of cluster members was performed.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "above") (:form . "above") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "all-against-all") (:form . "all-against-all")\n  (:end . 50) (:start . 35) (:id . 50))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.303) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100303@unknown@formal@none@1@S@If any pair exhibits such signals in both the N- and C-terminal parts, the cluster was retained.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "exhibit") (:form . "exhibits") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "N-") (:form . "N-") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 63)\n  (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 95)\n  (:start . 87) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.304) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100304@unknown@formal@none@1@S@Even if both the upstream and downstream regions of the inframe stop codon code proteins, they may be two adjacent genes instead of a readthrough protein.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "readthrough") (:form . "readthrough") (:end . 145)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 153)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x1.305.2) (:span 95 98)))\n (:ncues ((:id . :x1.305.1) (:span 121 131)))\n (:hscopes ((:id . :x1.305.2) (:span 95 153)))\n (:nscopes ((:id . :x1.305.1) (:span 121 153)))\n (:identifiers (:sid . :s1.305) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100305@unknown@formal@none@1@S@The second and third filtering processes remove such genes based on BLAST alignment patterns.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "filtering") (:form . "filtering") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "VBP") (:stem . "remove") (:form . "remove") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s1.306) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100306@unknown@formal@none@1@S@Although the boundary analysis applied previously has the same goal (Figure 1b), some gene pairs escaped elimination.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "boundary") (:form . "boundary") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "goal") (:form . "goal") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "1b") (:form . "1b") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "escape") (:form . "escaped") (:end . 104)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.307) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100307@unknown@formal@none@1@S@To enhance sensitivity of the filters, the whole length of an iORF was used as a BLAST query instead of the partial sequence, and the size of the BLAST database was increased from the 191 nonredundant genomes to the 328 complete genomes in GenomeNet and 246 draft genome sequences downloaded from GenBank in May 2006.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "enhance") (:form . "enhance") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "filter") (:form . "filters") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 86) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 92) (:start . 87)\n  (:id . 60))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 100)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 115)\n  (:start . 108) (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 124)\n  (:start . 116) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 68))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 138) (:start . 134)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 71))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 151)\n  (:start . 146) (:id . 72))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 160)\n  (:start . 152) (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 164) (:start . 161)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 174)\n  (:start . 165) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 179) (:start . 175)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 77))\n ((:tag . "CD") (:stem . "191") (:form . "191") (:end . 187) (:start . 184)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nonredundant") (:form . "nonredundant") (:end . 200)\n  (:start . 188) (:id . 79))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 208)\n  (:start . 201) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 82))\n ((:tag . "CD") (:stem . "328") (:form . "328") (:end . 219) (:start . 216)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 228)\n  (:start . 220) (:id . 84))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 236)\n  (:start . 229) (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 239) (:start . 237)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "GenomeNet") (:form . "GenomeNet") (:end . 249)\n  (:start . 240) (:id . 87))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 253) (:start . 250)\n  (:id . 88))\n ((:tag . "CD") (:stem . "246") (:form . "246") (:end . 257) (:start . 254)\n  (:id . 89))\n ((:tag . "NN") (:stem . "draft") (:form . "draft") (:end . 263)\n  (:start . 258) (:id . 90))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 270)\n  (:start . 264) (:id . 91))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 280)\n  (:start . 271) (:id . 92))\n ((:tag . "VBD") (:stem . "downloade") (:form . "downloaded") (:end . 291)\n  (:start . 281) (:id . 93))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 296) (:start . 292)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 304)\n  (:start . 297) (:id . 95))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 307) (:start . 305)\n  (:id . 96))\n ((:tag . "NNP") (:stem . "May") (:form . "May") (:end . 311) (:start . 308)\n  (:id . 97))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 316) (:start . 312)\n  (:id . 98))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 317) (:start . 316)\n  (:id . 99)))@@@1@58@((:ncues ((:id . :x1.308.1) (:span 93 103)))\n (:nscopes ((:id . :x1.308.1) (:span 93 124)))\n (:identifiers (:sid . :s1.308) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100308@unknown@formal@none@1@S@The second filter inspects synteny of iORFs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "filter") (:form . "filter") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "inspect") (:form . "inspects") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "synteny") (:form . "synteny") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s1.309) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100310@unknown@formal@none@1@S@Translated sequences of iORFs in the pre-filtering clusters were subjected to TBLASTN searches against the genome database.@(((:tag . "VBN") (:stem . "translate") (:form . "Translated") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "pre-filtering") (:form . "pre-filtering")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "subject") (:form . "subjected") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "NN") (:stem . "tblastn") (:form . "TBLASTN") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s1.311) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100311@unknown@formal@none@1@S@If both the best hits of the N- and C-terminal parts are statistically significant (E-value < 10-5), and distance between them is less than 1 kbp, we call these hits 'syntenic hits'.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "N-") (:form . "N-") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 46)\n  (:start . 36) (:id . 51))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 70) (:start . 57) (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 82)\n  (:start . 71) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "10-5") (:form . "10-5") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "NN") (:stem . "distance") (:form . "distance") (:end . 113)\n  (:start . 105) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 121)\n  (:start . 114) (:id . 64))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 134) (:start . 130)\n  (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 139) (:start . 135)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 141) (:start . 140)\n  (:id . 69))\n ((:tag . "NN") (:stem . "kbp") (:form . "kbp") (:end . 145) (:start . 142)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 71))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 149) (:start . 147)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "call") (:form . "call") (:end . 154) (:start . 150)\n  (:id . 73))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 160)\n  (:start . 155) (:id . 74))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 165) (:start . 161)\n  (:id . 75))\n ((:tag . "``") (:stem . "‘") (:form . "‘") (:end . 167) (:start . 166)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "syntenic") (:form . "syntenic") (:end . 175)\n  (:start . 167) (:id . 77))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 180) (:start . 176)\n  (:id . 78))\n ((:tag . "POS") (:stem . "'") (:form . "’") (:end . 181) (:start . 180)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s1.312) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100312@unknown@formal@none@1@S@If any syntenic hits with non-coinciding reading frames were found, the cluster was removed.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "syntenic") (:form . "syntenic") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "hit") (:form . "hits") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "non-coinciding") (:form . "non-coinciding")\n  (:end . 40) (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "frame") (:form . "frames") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s1.313) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100313@unknown@formal@none@1@S@The third filter uses co-occurrence of residues around the inframe stop codon as another source of information for screening stop codon readthrough.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "filter") (:form . "filter") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 110)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "screen") (:form . "screening") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "readthrough") (:form . "readthrough") (:end . 147)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s1.314) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100314@unknown@formal@none@1@S@Suppose a window of 21 residues centered at the inframe stop codon.@(((:tag . "VB") (:stem . "suppose") (:form . "Suppose") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "window") (:form . "window") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "VBN") (:stem . "center") (:form . "centered") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s1.315) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100315@unknown@formal@none@1@S@In prokaryotes, most stop-codon-encoded amino acids are located inside a domain, the unit of evolutionary sequence conservation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "stop-codon-encoded") (:form . "stop-codon-encoded")\n  (:end . 39) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "inside") (:form . "inside") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "unit") (:form . "unit") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 105)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 127)\n  (:start . 115) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s1.316) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100316@unknown@formal@none@1@S@Therefore, in an ideal situation the presence or absence of the 21 residues in alignments will be synchronized.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ideal") (:form . "ideal") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "situation") (:form . "situation") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "synchronize") (:form . "synchronized") (:end . 110)\n  (:start . 98) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x1.317.1) (:span 49 56)))\n (:nscopes ((:id . :x1.317.1) (:span 49 89)))\n (:identifiers (:sid . :s1.317) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100317@unknown@formal@none@1@S@In contrast, if the iORF is actually two adjacent genes, then upstream and downstream residues of the stop codon will appear separately in many alignments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "iorf") (:form . "iORF") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "RB") (:stem . "actually") (:form . "actually") (:end . 36)\n  (:start . 28) (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 85)\n  (:start . 75) (:id . 57))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 124)\n  (:start . 118) (:id . 64))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 135)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 154)\n  (:start . 144) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.318) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100318@unknown@formal@none@1@S@We defined a co-occurrence matrix as a 21 × 21 matrix whose (i,j)-th element represents how often residue i and j appeared simultaneously in N alignments.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "define") (:form . "defined") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "×") (:form . "×") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "i,j)-th") (:form . "i,j)-th") (:end . 68)\n  (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 87)\n  (:start . 77) (:id . 57))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "NN") (:stem . "i") (:form . "i") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "j") (:form . "j") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 137) (:start . 123) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 153)\n  (:start . 143) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s1.319) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100320@unknown@formal@none@1@S@By definition, the more often the upstream and downstream residues of the inframe stop codon co-occur in the alignments, the higher the density in the upper right quarter of the matrix.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "co-occur") (:form . "co-occur") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 119)\n  (:start . 109) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 131)\n  (:start . 125) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "upper") (:form . "upper") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "JJ") (:stem . "right") (:form . "right") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "quarter") (:form . "quarter") (:end . 170)\n  (:start . 163) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 73))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 184)\n  (:start . 178) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s1.321) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100321@unknown@formal@none@1@S@If average density in the quarter was lower than 0.85, the cluster was filtered out.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "quarter") (:form . "quarter") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "0.85") (:form . "0.85") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cluster") (:form . "cluster") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s1.322) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100322@unknown@formal@none@1@S@Stop codon usage@(((:tag . "NNP") (:stem . "Stop") (:form . "Stop") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 16) (:start . 11)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s1.323) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100323@unknown@formal@none@1@S@For each organism, its iORFs were extracted from the pre-filtering clusters, and codon usage at the inframe stop positions was counted.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "iorf") (:form . "iORFs") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "pre-filtering") (:form . "pre-filtering")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "inframe") (:form . "inframe") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "count") (:form . "counted") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.324) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100324@unknown@formal@none@1@S@Codon usage at the C-terminal stop codons in its proteome was also computed using data of coding sequences downloaded from KEGG GENES 25.@(((:tag . "NNP") (:stem . "Codon") (:form . "Codon") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "usage") (:form . "usage") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 96) (:start . 90)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "KEGG") (:form . "KEGG") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GENES") (:form . "GENES") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s1.325) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100325@unknown@formal@none@1@S@These data were combined into a 3 × 2 matrix, and Fisher's exact test was applied.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "SYM") (:stem . "×") (:form . "×") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 44)\n  (:start . 38) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Fisher") (:form . "Fisher") (:end . 56)\n  (:start . 50) (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 58) (:start . 56)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 64) (:start . 59)\n  (:id . 56))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 69) (:start . 65)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 81)\n  (:start . 74) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s1.326) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100326@unknown@formal@none@1@S@The p-value was corrected for multiple testing using the Bonferroni correction because there were 127 organisms in the pre-filtering clusters.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p-value") (:form . "p-value") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "correct") (:form . "corrected") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Bonferroni") (:form . "Bonferroni") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 92) (:start . 87)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "CD") (:stem . "127") (:form . "127") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "pre-filtering") (:form . "pre-filtering")\n  (:end . 132) (:start . 119) (:id . 60))\n ((:tag . "NNS") (:stem . "cluster") (:form . "clusters") (:end . 141)\n  (:start . 133) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s1.327) (:did . :1471-2105-8-225)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100327@unknown@formal@none@1@S@Probabilistic prediction and ranking of human protein-protein interactions@(((:tag . "JJ") (:stem . "probabilistic") (:form . "Probabilistic")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 24)\n  (:start . 14) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ranking") (:form . "ranking") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 61) (:start . 46) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 74)\n  (:start . 62) (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.1) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100328@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.2) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100330@unknown@formal@none@1@S@Although the prediction of protein-protein interactions has been extensively investigated for yeast, few such datasets exist for the far larger proteome in human.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 42) (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 55)\n  (:start . 43) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 64) (:start . 60)\n  (:id . 49))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 76)\n  (:start . 65) (:id . 50))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 89)\n  (:start . 77) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 52))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 99) (:start . 94)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 118)\n  (:start . 110) (:id . 57))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 124)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 60))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 152)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "human") (:form . "human") (:end . 161)\n  (:start . 156) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.4) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100331@unknown@formal@none@1@S@Furthermore, it has recently been estimated that the overall average false positive rate of available computational and high-throughput experimental interaction datasets is as high as 90%.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 115) (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 135) (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 148)\n  (:start . 136) (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 160)\n  (:start . 149) (:id . 62))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 169)\n  (:start . 161) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 172) (:start . 170)\n  (:id . 64))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 180) (:start . 176)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x2.5.1) (:span 34 43)))\n (:hscopes ((:id . :x2.5.1) (:span 34 187)))\n (:identifiers (:sid . :s2.5) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100332@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.6) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100333@unknown@formal@none@1@S@The prediction of human protein-protein interactions was investigated by combining orthogonal protein features within a probabilistic framework.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 69)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 82)\n  (:start . 73) (:id . 51))\n ((:tag . "JJ") (:stem . "orthogonal") (:form . "orthogonal") (:end . 93)\n  (:start . 83) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 53))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 110)\n  (:start . 102) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 117)\n  (:start . 111) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 133) (:start . 120) (:id . 57))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 143)\n  (:start . 134) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.7) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100334@unknown@formal@none@1@S@The features include co-expression, orthology to known interacting proteins and the full-Bayesian combination of subcellular localization, co-occurrence of domains and post-translational modifications.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "co-expression") (:form . "co-expression")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "orthology") (:form . "orthology") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "full-bayesian") (:form . "full-Bayesian")\n  (:end . 97) (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 109)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 124)\n  (:start . 113) (:id . 57))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 137)\n  (:start . 125) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 59))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 152) (:start . 139) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 163)\n  (:start . 156) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "post-translational") (:form . "post-translational")\n  (:end . 186) (:start . 168) (:id . 64))\n ((:tag . "NNS") (:stem . "modification") (:form . "modifications")\n  (:end . 200) (:start . 187) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.8) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100335@unknown@formal@none@1@S@A novel scoring function for local network topology was also investigated.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 73)\n  (:start . 61) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.9) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100336@unknown@formal@none@1@S@This topology feature greatly enhanced the predictions and together with the full-Bayes combined features, made the largest contribution to the predictions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBD") (:stem . "enhance") (:form . "enhanced") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 54)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "full-bayes") (:form . "full-Bayes") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 96)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 105)\n  (:start . 97) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "make") (:form . "made") (:end . 111) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "large") (:form . "largest") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 136)\n  (:start . 124) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 155)\n  (:start . 144) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.10) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100337@unknown@formal@none@1@S@Using a conservative threshold, our most accurate predictor identifies 37606 human interactions, 32892 (80%) of which are not present in other publicly available large human interaction datasets, thus substantially increasing the coverage of the human interaction map.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "conservative") (:form . "conservative") (:end . 20)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "CD") (:stem . "37606") (:form . "37606") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 95)\n  (:start . 83) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "CD") (:stem . "32892") (:form . "32892") (:end . 102) (:start . 97)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 133)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "RB") (:stem . "publicly") (:form . "publicly") (:end . 151)\n  (:start . 143) (:id . 68))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 161)\n  (:start . 152) (:id . 69))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 167)\n  (:start . 162) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 173)\n  (:start . 168) (:id . 71))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 185)\n  (:start . 174) (:id . 72))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 74))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 200) (:start . 196)\n  (:id . 75))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 214) (:start . 201) (:id . 76))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 225)\n  (:start . 215) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 238)\n  (:start . 230) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 251)\n  (:start . 246) (:id . 82))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 263)\n  (:start . 252) (:id . 83))\n ((:tag . "NN") (:stem . "map") (:form . "map") (:end . 267) (:start . 264)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x2.11.1) (:span 122 125)))\n (:nscopes ((:id . :x2.11.1) (:span 122 194)))\n (:identifiers (:sid . :s2.11) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100338@unknown@formal@none@1@S@A subset of the 32892 novel predicted interactions have been independently validated.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "32892") (:form . "32892") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 74) (:start . 61) (:id . 52))\n ((:tag . "VBN") (:stem . "validate") (:form . "validated") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.12) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100340@unknown@formal@none@1@S@Since the new method scores and ranks all human protein pairs, smaller subsets of higher quality can be generated thus leading to even lower false positive prediction rates.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "rank") (:form . "ranks") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 88) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 113)\n  (:start . 104) (:id . 61))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "VB") (:stem . "lower") (:form . "lower") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 166)\n  (:start . 156) (:id . 69))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.14) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100341@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.15) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100342@unknown@formal@none@1@S@The set of interactions predicted in this work increases the coverage of the human interaction map and will help determine the highest confidence human interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 94)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "map") (:form . "map") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 134)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 145)\n  (:start . 135) (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 164)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.16) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100343@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.17) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100344@unknown@formal@none@1@S@Protein-protein interactions perform and regulate fundamental cellular processes.@(((:tag . "JJ") (:stem . "protein-protein") (:form . "Protein-protein")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 28)\n  (:start . 16) (:id . 43))\n ((:tag . "VBP") (:stem . "perform") (:form . "perform") (:end . 36)\n  (:start . 29) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "JJ") (:stem . "fundamental") (:form . "fundamental") (:end . 61)\n  (:start . 50) (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 70)\n  (:start . 62) (:id . 48))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 80)\n  (:start . 71) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.18) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100345@unknown@formal@none@1@S@The comprehensive study of such interactions on a genome-wide scale will lead to a clearer understanding of diverse cellular processes and of the molecular mechanisms of disease.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "comprehensive") (:form . "comprehensive")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "genome-wide") (:form . "genome-wide") (:end . 61)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "clear") (:form . "clearer") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 104) (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 134)\n  (:start . 125) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 166)\n  (:start . 156) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.19) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
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5100347@unknown@formal@none@1@S@High-throughput datasets have been generated for model organisms such as yeast 23456, worm 7 and fly 89 as well as Escherichia coli 10.@(((:tag . "JJ") (:stem . "high-throughput") (:form . "High-throughput")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 24)\n  (:start . 16) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 29) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 54) (:start . 49)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 64)\n  (:start . 55) (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 69) (:start . 65)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 78) (:start . 73)\n  (:id . 52))\n ((:tag . "CD") (:stem . "23456") (:form . "23456") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "worm") (:form . "worm") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "VB") (:stem . "fly") (:form . "fly") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "CD") (:stem . "89") (:form . "89") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Escherichia") (:form . "Escherichia") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 131) (:start . 127)\n  (:id . 64))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.21) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
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5100350@unknown@formal@none@1@S@Analysis of the high-throughput datasets has shown that they overlap very little with each other, suggesting that their coverage is low.@(((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 31) (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x2.24.1) (:span 98 108)))\n (:hscopes ((:id . :x2.24.1) (:span 98 135)))\n (:identifiers (:sid . :s2.24) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100351@unknown@formal@none@1@S@Indeed, it has been estimated recently that the current yeast and human protein interaction maps are only 50% and 10% complete, respectively 18.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "NNS") (:stem . "map") (:form . "maps") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 126)\n  (:start . 118) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 140)\n  (:start . 128) (:id . 67))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x2.25.1) (:span 20 29)))\n (:hscopes ((:id . :x2.25.1) (:span 20 140)))\n (:identifiers (:sid . :s2.25) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100352@unknown@formal@none@1@S@The low coverage and variable quality of the experimental interaction datasets have prompted many groups to investigate computational methods to predict interactions or to determine the most likely interactions seen in the high-throughput datasets.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 57)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 83) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "prompt") (:form . "prompted") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 133) (:start . 120) (:id . 59))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 141)\n  (:start . 134) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 61))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 152)\n  (:start . 145) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 165)\n  (:start . 153) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 168) (:start . 166)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 65))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 181)\n  (:start . 172) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 67))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 190) (:start . 186)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 197)\n  (:start . 191) (:id . 69))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 210)\n  (:start . 198) (:id . 70))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 215) (:start . 211)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 238) (:start . 223) (:id . 74))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 247)\n  (:start . 239) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.26) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100353@unknown@formal@none@1@S@The different approaches to predict interactions can be grouped into five main categories:@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "category") (:form . "categories") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.27) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100354@unknown@formal@none@1@S@1) Predictors based on sequence and structure exploit the observation that some pairs of sequence motifs, domains and structural families tend to interact preferentially.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 2) (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "predictor") (:form . "Predictors") (:end . 13)\n  (:start . 3) (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "VBP") (:stem . "exploit") (:form . "exploit") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 69)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 128)\n  (:start . 118) (:id . 62))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "VBP") (:stem . "tend") (:form . "tend") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 169) (:start . 155) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s2.28) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100355@unknown@formal@none@1@S@Some methods predict interaction from sequence-motifs found to be over-represented in interacting protein pairs 19, or by considering the physico-chemical properties and the location of groups of amino acids in the sequence 2021.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence-motif") (:form . "sequence-motifs")\n  (:end . 53) (:start . 38) (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 59) (:start . 54)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "over-represented") (:form . "over-represented")\n  (:end . 82) (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 97)\n  (:start . 86) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 111)\n  (:start . 106) (:id . 55))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 133)\n  (:start . 122) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "physico-chemical") (:form . "physico-chemical")\n  (:end . 154) (:start . 138) (:id . 62))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 165)\n  (:start . 155) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 169) (:start . 166)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 65))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 182)\n  (:start . 174) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 185) (:start . 183)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 192)\n  (:start . 186) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 201)\n  (:start . 196) (:id . 70))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 207)\n  (:start . 202) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 223)\n  (:start . 215) (:id . 74))\n ((:tag . "CD") (:stem . "2021") (:form . "2021") (:end . 228) (:start . 224)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.29) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100356@unknown@formal@none@1@S@Others investigate the co-occurrence in interacting proteins of specific protein domains or their structural family classification 2223.@(((:tag . "NNS") (:stem . "other") (:form . "Others") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 36) (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 51)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 88)\n  (:start . 81) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 97)\n  (:start . 92) (:id . 54))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 108)\n  (:start . 98) (:id . 55))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "NN") (:stem . "classification") (:form . "classification")\n  (:end . 130) (:start . 116) (:id . 57))\n ((:tag . "CD") (:stem . "2223") (:form . "2223") (:end . 135) (:start . 131)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.30) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100357@unknown@formal@none@1@S@When three-dimensional structures are available for both proteins thought to interact, high quality predictions and additional information such as the residues involved in the interaction and their binding affinity may be estimated (reviewed in 24).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "three-dimensional") (:form . "three-dimensional")\n  (:end . 22) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 33)\n  (:start . 23) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 47)\n  (:start . 38) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 51) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 73)\n  (:start . 66) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 85)\n  (:start . 77) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 91) (:start . 87)\n  (:id . 54))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 111)\n  (:start . 100) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 126)\n  (:start . 116) (:id . 58))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 138)\n  (:start . 127) (:id . 59))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 143) (:start . 139)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 146) (:start . 144)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 159)\n  (:start . 151) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 168)\n  (:start . 160) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 66))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 187)\n  (:start . 176) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 191) (:start . 188)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 197)\n  (:start . 192) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 205)\n  (:start . 198) (:id . 70))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 214)\n  (:start . 206) (:id . 71))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 218) (:start . 215)\n  (:id . 72))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 221) (:start . 219)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 231)\n  (:start . 222) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 241)\n  (:start . 233) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 244) (:start . 242)\n  (:id . 77))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 247) (:start . 245)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x2.31.1) (:span 215 218)) ((:id . :x2.31.2) (:span 66 73)))\n (:hscopes ((:id . :x2.31.1) (:span 87 231)) ((:id . :x2.31.2) (:span 52 85)))\n (:identifiers (:sid . :s2.31) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100358@unknown@formal@none@1@S@Similarly, when two proteins show clear sequence similarity to proteins that exist in a complex for which the three-dimensional structure is known, detailed predictions of the atomic-level interactions may be made.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "three-dimensional") (:form . "three-dimensional")\n  (:end . 127) (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 168)\n  (:start . 157) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "atomic-level") (:form . "atomic-level") (:end . 188)\n  (:start . 176) (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 201)\n  (:start . 189) (:id . 71))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 205) (:start . 202)\n  (:id . 72))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 208) (:start . 206)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 213) (:start . 209)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x2.32.1) (:span 202 205)))\n (:hscopes ((:id . :x2.32.1) (:span 148 213)))\n (:identifiers (:sid . :s2.32) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100360@unknown@formal@none@1@S@2) Predictors based on comparative genomics have been exploited primarily in prokaryotes.@(((:tag . "LS") (:stem . "2") (:form . "2") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 2) (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "predictor") (:form . "Predictors") (:end . 13)\n  (:start . 3) (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "comparative") (:form . "comparative") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "genomic") (:form . "genomics") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "exploit") (:form . "exploited") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "prokaryote") (:form . "prokaryotes") (:end . 88)\n  (:start . 77) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.34) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100361@unknown@formal@none@1@S@They consider the physical location of genes, as well as their pattern of occurrence and evolutionary rate, to predict interactions or functional relationships between protein pairs.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 62)\n  (:start . 57) (:id . 53))\n ((:tag . "NN") (:stem . "pattern") (:form . "pattern") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 101)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 131)\n  (:start . 119) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 145)\n  (:start . 135) (:id . 65))\n ((:tag . "NNS") (:stem . "relationship") (:form . "relationships")\n  (:end . 159) (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 167)\n  (:start . 160) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 175)\n  (:start . 168) (:id . 68))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 181)\n  (:start . 176) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.35) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100362@unknown@formal@none@1@S@Some predictors make use of the observation that neighboring genes whose relative location is conserved across several prokaryotic organisms are likely to interact 26.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 43)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 144) (:start . 141)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 151)\n  (:start . 145) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 163)\n  (:start . 155) (:id . 64))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.36.1) (:span 145 151)))\n (:hscopes ((:id . :x2.36.1) (:span 49 163)))\n (:identifiers (:sid . :s2.36) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100363@unknown@formal@none@1@S@Other predictors exploit the observation that gene pairs that co-occur in related species or that co-evolve also tend to be more likely to interact 27282930.@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "exploit") (:form . "exploit") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "co-occur") (:form . "co-occur") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "co-evolve") (:form . "co-evolve") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "VB") (:stem . "tend") (:form . "tend") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 147)\n  (:start . 139) (:id . 65))\n ((:tag . "CD") (:stem . "27282930") (:form . "27282930") (:end . 156)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x2.37.1) (:span 129 135)))\n (:hscopes ((:id . :x2.37.1) (:span 46 147)))\n (:identifiers (:sid . :s2.37) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100364@unknown@formal@none@1@S@In addition, domains that exist as separate proteins in some genomes but are also seen fused in a single protein in other genomes have been used to suggest the isolated domains may interact 3132.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "fuse") (:form . "fused") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 104)\n  (:start . 98) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 139) (:start . 135)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 144) (:start . 140)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 155)\n  (:start . 148) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 168)\n  (:start . 160) (:id . 72))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 176)\n  (:start . 169) (:id . 73))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 180) (:start . 177)\n  (:id . 74))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 189)\n  (:start . 181) (:id . 75))\n ((:tag . "CD") (:stem . "3132") (:form . "3132") (:end . 194) (:start . 190)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x2.38.1) (:span 177 180))\n  ((:id . :x2.38.2) (:span 148 155)))\n (:hscopes ((:id . :x2.38.1) (:span 177 189))\n  ((:id . :x2.38.2) (:span 148 189)))\n (:identifiers (:sid . :s2.38) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100365@unknown@formal@none@1@S@3) Predictors based on orthology work on the assumption that the orthologs of a protein pair that are known to interact in one organism will also interact.@(((:tag . "LS") (:stem . "3") (:form . "3") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 2) (:start . 1) (:id . 43))\n ((:tag . "NNS") (:stem . "predictor") (:form . "Predictors") (:end . 13)\n  (:start . 3) (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "orthology") (:form . "orthology") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 119)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 154)\n  (:start . 146) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x2.39.1) (:span 45 55)))\n (:hscopes ((:id . :x2.39.1) (:span 45 154)))\n (:identifiers (:sid . :s2.39) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100366@unknown@formal@none@1@S@Such relationships are often referred to as interologs 33.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "relationship") (:form . "relationships")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "interolog") (:form . "interologs") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s2.40) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100367@unknown@formal@none@1@S@For example, at BLAST e-values below 10-10, it has been shown that 16–30% of yeast interactions can be transferred to the worm 34 while further studies have estimated that a joint e-value below 10-70 is required to transfer interactions reliably between organisms 35.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "e-value") (:form . "e-values") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "10-10") (:form . 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5100368@unknown@formal@none@1@S@Interologs have been used to predict protein-protein interactions in human 36.@(((:tag . "NNS") (:stem . "interolog") (:form . "Interologs") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 52) (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 65)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 74) (:start . 69)\n  (:id . 51))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.42) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100370@unknown@formal@none@1@S@Some predictors exploit the observation that there is a significant correlation in the expression levels of transcripts encoding proteins that interact 37.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "exploit") (:form . "exploit") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 128)\n  (:start . 120) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 151)\n  (:start . 143) (:id . 62))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 154) (:start . 152)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.44) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100371@unknown@formal@none@1@S@Since proteins must be co-localized in order to interact, protein subcellular localization has often been used to assess the quality of interaction datasets 3839.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "co-localize") (:form . "co-localized") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 147)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "CD") (:stem . "3839") (:form . "3839") (:end . 161) (:start . 157)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.45) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
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5100381@unknown@formal@none@1@S@This resulted in over 70000 predicted physical interactions involving approximately 6200 human proteins.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "70000") (:form . "70000") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 83) (:start . 70) (:id . 51))\n ((:tag . "CD") (:stem . "6200") (:form . "6200") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 94) (:start . 89)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 103)\n  (:start . 95) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.55) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100382@unknown@formal@none@1@S@A second method integrated expression data, orthology, protein domain data and functional annotations into a probabilistic framework and resulted in the prediction of nearly 40000 human protein interactions 46.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "orthology") (:form . "orthology") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 101)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 132)\n  (:start . 123) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 145)\n  (:start . 137) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 163)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . "CD") (:stem . "40000") (:form . "40000") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 185)\n  (:start . 180) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 193)\n  (:start . 186) (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 206)\n  (:start . 194) (:id . 71))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x2.56.1) (:span 153 163)))\n (:hscopes ((:id . :x2.56.1) (:span 153 206)))\n (:identifiers (:sid . :s2.56) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
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5100384@unknown@formal@none@1@S@In this paper, the prediction of physical interactions between human proteins has been investigated by integrating in a Bayesian framework several different pieces of evidence including orthology, functional features and local network topology.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 29)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 99)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "integrate") (:form . "integrating") (:end . 114)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "bayesian") (:form . "Bayesian") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "NNS") (:stem . "piece") (:form . "pieces") (:end . 163)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 175)\n  (:start . 167) (:id . 67))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "NN") (:stem . "orthology") (:form . "orthology") (:end . 195)\n  (:start . 186) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 207)\n  (:start . 197) (:id . 71))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 216)\n  (:start . 208) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 226)\n  (:start . 221) (:id . 74))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 234)\n  (:start . 227) (:id . 75))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 243)\n  (:start . 235) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s2.58) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100385@unknown@formal@none@1@S@In order to increase the accuracy and coverage of the predictions, different types of negative data (non-interacting protein pairs) were explored to train the predictor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 116) (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "VB") (:stem . "train") (:form . "train") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 168)\n  (:start . 159) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.59) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100386@unknown@formal@none@1@S@The most accurate of the predictors was then used to assess the likelihood of pair-wise interaction for over 20000 human proteins from the IPI (International Protein Index) database.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "pair-wise") (:form . "pair-wise") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "CD") (:stem . "20000") (:form . "20000") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "International") (:form . "International")\n  (:end . 157) (:start . 144) (:id . 67))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "NNP") (:stem . "Index") (:form . "Index") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s2.60) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100387@unknown@formal@none@1@S@These predictions provide a likelihood of interaction for over 260 million human protein pairs and lead to the prediction of over 37000 human interactions.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "260") (:form . "260") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "CD") (:stem . "million") (:form . "million") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "CD") (:stem . "37000") (:form . "37000") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 154)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.61.1) (:span 111 121)) ((:id . :x2.61.2) (:span 28 38)))\n (:hscopes ((:id . :x2.61.1) (:span 111 154))\n  ((:id . :x2.61.2) (:span 28 94)))\n (:identifiers (:sid . :s2.61) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100388@unknown@formal@none@1@S@They should thus augment current knowledge of the human interactome as well as the understanding of the relationship between distinct cellular processes.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "augment") (:form . "augment") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 67)\n  (:start . 56) (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 116)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 124)\n  (:start . 117) (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 142)\n  (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x2.62.1) (:span 5 11)))\n (:hscopes ((:id . :x2.62.1) (:span 5 152)))\n (:identifiers (:sid . :s2.62) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100390@unknown@formal@none@1@S@Architecture of the predictor and training of the modules@(((:tag . "NNP") (:stem . "Architecture") (:form . "Architecture") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 57)\n  (:start . 50) (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.64) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100391@unknown@formal@none@1@S@The prediction of human protein-protein interactions was investigated in a Bayesian framework by considering combinations of individual protein features known to be indicative of interaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 39) (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 69)\n  (:start . 57) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "bayesian") (:form . "Bayesian") (:end . 83)\n  (:start . 75) (:id . 52))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 93)\n  (:start . 84) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 108)\n  (:start . 97) (:id . 55))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 121)\n  (:start . 109) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 135)\n  (:start . 125) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 143)\n  (:start . 136) (:id . 59))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 152)\n  (:start . 144) (:id . 60))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 158)\n  (:start . 153) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 164) (:start . 162)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "indicative") (:form . "indicative") (:end . 175)\n  (:start . 165) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 190)\n  (:start . 179) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.65) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100392@unknown@formal@none@1@S@The seven individual features considered are summarized in Table 1 and detailed in the Methods section.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "summarize") (:form . "summarized") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detail") (:form . "detailed") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Methods") (:form . "Methods") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.66) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100393@unknown@formal@none@1@S@As indicated in Table 1, the different features were grouped into five distinct modules: Expression (E), Orthology (O), Combined (C), Disorder (D) and Transitive (T).@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 38)\n  (:start . 29) (:id . 49))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 114)\n  (:start . 105) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "O") (:form . "O") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 128)\n  (:start . 120) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 131) (:start . 130)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 132) (:start . 131)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 142)\n  (:start . 134) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 145) (:start . 144)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 161)\n  (:start . 151) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 79))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 164) (:start . 163)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s2.67) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100394@unknown@formal@none@1@S@Figure 1 illustrates the training scheme and architecture of the method.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "illustrate") (:form . "illustrates") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "architecture") (:form . "architecture") (:end . 57)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.68) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100395@unknown@formal@none@1@S@The Expression, Orthology, Combined and Disorder modules can calculate likelihood ratios (LR) of interaction independently and are referred to as the Group A modules (Figure 1A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "calculate") (:form . "calculate") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "LR") (:form . "LR") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 122) (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 155)\n  (:start . 150) (:id . 67))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 165)\n  (:start . 158) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 173)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s2.69) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100396@unknown@formal@none@1@S@The product of their likelihood ratios is referred to as the Preliminary Score.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 20)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "Preliminary") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "score") (:form . "Score") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.70) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100397@unknown@formal@none@1@S@The Transitive module considers the local topology of the network predicted by the group A modules and thus requires the completion of their analysis to calculate its own likelihood ratios of interaction (Figure 1B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "completion") (:form . "completion") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 149)\n  (:start . 141) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "VB") (:stem . "calculate") (:form . "calculate") (:end . 162)\n  (:start . 153) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 181)\n  (:start . 171) (:id . 70))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 188)\n  (:start . 182) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 203)\n  (:start . 192) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 205) (:start . 204)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 211)\n  (:start . 205) (:id . 75))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 214) (:start . 212)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s2.71) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100398@unknown@formal@none@1@S@As such, all combinations of the Group A modules can be used to predict interaction in the presence or absence of the Transitive module.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 25)\n  (:start . 13) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 71)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 83)\n  (:start . 72) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 128)\n  (:start . 118) (:id . 65))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 135)\n  (:start . 129) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x2.72.1) (:span 103 110)))\n (:nscopes ((:id . :x2.72.1) (:span 103 135)))\n (:identifiers (:sid . :s2.72) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100400@unknown@formal@none@1@S@Features considered in the prediction of interactions for each module@(((:tag . "NNPS") (:stem . "Feature") (:form . "Features") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 53)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 69)\n  (:start . 63) (:id . 51)))@@@1@10@((:identifiers (:sid . :s2.74) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5100401@unknown@formal@none@1@S@Architecture of the predictor and likelihoods of the modules@(((:tag . "NNP") (:stem . "Architecture") (:form . "Architecture") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "likelihood") (:form . "likelihoods") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 60)\n  (:start . 53) (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.75) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100402@unknown@formal@none@1@S@Architecture of the predictor and likelihoods of the modules.@(((:tag . "NNP") (:stem . "Architecture") (:form . "Architecture") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "likelihood") (:form . "likelihoods") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s2.76) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100403@unknown@formal@none@1@S@The predictor consists of two different parts (A and B) which are trained consecutively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 73)\n  (:start . 66) (:id . 56))\n ((:tag . "RB") (:stem . "consecutively") (:form . "consecutively")\n  (:end . 87) (:start . 74) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.77) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100404@unknown@formal@none@1@S@The Group A modules (shown in panel A) are trained in parallel.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 50)\n  (:start . 43) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 54))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 62)\n  (:start . 54) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.78) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100405@unknown@formal@none@1@S@The likelihood ratios (LR) for most of their states are shown in panel A (their complete likelihood ratios are available in Additional File 4).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "LR") (:form . "LR") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 44)\n  (:start . 39) (:id . 51))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 51)\n  (:start . 45) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 70) (:start . 65)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 79)\n  (:start . 74) (:id . 59))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 88)\n  (:start . 80) (:id . 60))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 99)\n  (:start . 89) (:id . 61))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 106)\n  (:start . 100) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 120)\n  (:start . 111) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 134)\n  (:start . 124) (:id . 66))\n ((:tag . "NNP") (:stem . "File") (:form . "File") (:end . 139) (:start . 135)\n  (:id . 67))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 141) (:start . 140)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.79) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100406@unknown@formal@none@1@S@The product of the likelihood ratios of all Group A modules considered in a given prediction is referred to as the preliminary score (PS) and can be calculated for all human protein pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 104)\n  (:start . 96) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 126)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "PS") (:form . "PS") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 148) (:start . 146)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 159)\n  (:start . 149) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 167) (:start . 164)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 173)\n  (:start . 168) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 187)\n  (:start . 182) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s2.80) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100407@unknown@formal@none@1@S@If the Transitive module is not considered, the final likelihood ratios assigned to all protein pairs is the preliminary score (PS).@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "VBN") (:stem . "assign") (:form . "assigned") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 95)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 120)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "PS") (:form . "PS") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x2.81.1) (:span 28 31)))\n (:nscopes ((:id . :x2.81.1) (:span 3 42)))\n (:identifiers (:sid . :s2.81) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100408@unknown@formal@none@1@S@If the Transitive module is considered, the local topology of the network determined by the assignment of preliminary scores to all protein pairs considered in the training set is used to calculate the likelihood ratios for the transitive module (shown in panel B) for every protein pair in the training set.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "assignment") (:form . "assignment") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 117)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "VB") (:stem . "calculate") (:form . "calculate") (:end . 197)\n  (:start . 188) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 212)\n  (:start . 202) (:id . 76))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 219)\n  (:start . 213) (:id . 77))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 223) (:start . 220)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 238)\n  (:start . 228) (:id . 80))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 245)\n  (:start . 239) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 247) (:start . 246)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 252)\n  (:start . 247) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 255) (:start . 253)\n  (:id . 84))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 261)\n  (:start . 256) (:id . 85))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 263) (:start . 262)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 264) (:start . 263)\n  (:id . 87))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 268) (:start . 265)\n  (:id . 88))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 274)\n  (:start . 269) (:id . 89))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 282)\n  (:start . 275) (:id . 90))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 287) (:start . 283)\n  (:id . 91))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 290) (:start . 288)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 294) (:start . 291)\n  (:id . 93))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 303)\n  (:start . 295) (:id . 94))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 307) (:start . 304)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 308) (:start . 307)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s2.82) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100410@unknown@formal@none@1@S@For the Orthology module: YL, YM, YH: yeast low, medium and high scoring bins; FL, FM, FH: fly low, medium and high scoring bins; WL, WM, WH: worm low, medium and high scoring bins; HM and HL: medium and low scoring bins for human protein pairs that have human paralogs; > 1 organism: bin for human protein pairs that have interologs in more than one organism.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "YL") (:form . "YL") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "YM") (:form . "YM") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "YH") (:form . "YH") (:end . 36) (:start . 34)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 37) (:start . 36)\n  (:id . 52))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 43) (:start . 38)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 47) (:start . 44)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "medium") (:form . "medium") (:end . 55)\n  (:start . 49) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 64) (:start . 60)\n  (:id . 58))\n ((:tag . "NN") (:stem . "scoring") (:form . 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"in") (:end . 336) (:start . 334)\n  (:id . 122))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 341) (:start . 337)\n  (:id . 123))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 346) (:start . 342)\n  (:id . 124))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 350) (:start . 347)\n  (:id . 125))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 359)\n  (:start . 351) (:id . 126))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 360) (:start . 359)\n  (:id . 127)))@@@1@86@((:identifiers (:sid . :s2.84) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100411@unknown@formal@none@1@S@For the Combined module, –— refers to the lowest scoring bin (for the domain (Dom), post-translational modification (PTM) and subcellular localization (Loc) features), – refers to the second lowest scoring bin and +, ++, +++ refer respectively to the third highest, second highest and highest scoring bins.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . ":") (:stem . "–") (:form . "–") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "—") (:form . "—") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . 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"highest") (:end . 292)\n  (:start . 285) (:id . 101))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 300)\n  (:start . 293) (:id . 102))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 305) (:start . 301)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s2.85) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100412@unknown@formal@none@1@S@The likelihood ratios of interaction are evaluated for each module by considering the relative proportions of positive and negative training examples that have a specific state (i.e. that fall in a particular bin of a module).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NNS") (:stem . "proportion") (:form . "proportions") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 131)\n  (:start . 123) (:id . 60))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 159) (:start . 155)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 170)\n  (:start . 162) (:id . 66))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 176)\n  (:start . 171) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 68))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "NN") (:stem . "fall") (:form . "fall") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 208)\n  (:start . 198) (:id . 74))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 212) (:start . 209)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 217) (:start . 216)\n  (:id . 77))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 224)\n  (:start . 218) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 225) (:start . 224)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s2.86) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100413@unknown@formal@none@1@S@The datasets used to train the predictor consisted of 26896 known human protein interactions extracted from the Human Protein Reference Database (HPRD) 15 and approximately 100 times more randomly chosen protein pairs used as negative examples.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "train") (:form . "train") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "26896") (:form . "26896") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 92)\n  (:start . 80) (:id . 55))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 117)\n  (:start . 112) (:id . 59))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "NNP") (:stem . "Reference") (:form . "Reference") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "NNP") (:stem . "Database") (:form . "Database") (:end . 144)\n  (:start . 136) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 172) (:start . 159) (:id . 68))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 187) (:start . 183)\n  (:id . 71))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 196)\n  (:start . 188) (:id . 72))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 203)\n  (:start . 197) (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 211)\n  (:start . 204) (:id . 74))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 217)\n  (:start . 212) (:id . 75))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 225) (:start . 223)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 234)\n  (:start . 226) (:id . 78))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 243)\n  (:start . 235) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s2.87) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100414@unknown@formal@none@1@S@The composition of the datasets and likelihood ratio calculations are explained in greater detail in the Methods section.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "calculation") (:form . "calculations") (:end . 65)\n  (:start . 53) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 90)\n  (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Methods") (:form . "Methods") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.88) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100415@unknown@formal@none@1@S@Once the final likelihood ratio of interaction (LRfinal) is calculated for a given protein pair as shown in Figure 1B, it is possible to estimate the posterior odds ratio of interaction by multiplying the final likelihood ratio by the prior odds ratio of interaction.@(((:tag . "RB") (:stem . "once") (:form . "Once") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "LRfinal") (:form . "LRfinal") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 70)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 133)\n  (:start . 125) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 68))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 145)\n  (:start . 137) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 159)\n  (:start . 150) (:id . 71))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 170)\n  (:start . 165) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 74))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 185)\n  (:start . 174) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "multiply") (:form . "multiplying") (:end . 200)\n  (:start . 189) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 210)\n  (:start . 205) (:id . 79))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 221)\n  (:start . 211) (:id . 80))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 227)\n  (:start . 222) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 230) (:start . 228)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 240)\n  (:start . 235) (:id . 84))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 245) (:start . 241)\n  (:id . 85))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 251)\n  (:start . 246) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 254) (:start . 252)\n  (:id . 87))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 266)\n  (:start . 255) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x2.89.1) (:span 125 133)))\n (:hscopes ((:id . :x2.89.1) (:span 125 266)))\n (:identifiers (:sid . :s2.89) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100416@unknown@formal@none@1@S@Protein pairs that have a posterior odds of interaction above 1 are more likely to interact than not to interact, thus providing an obvious threshold to predict interacting proteins.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 128)\n  (:start . 119) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 160)\n  (:start . 153) (:id . 69))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 172)\n  (:start . 161) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x2.90.2) (:span 73 79)))\n (:ncues ((:id . :x2.90.1) (:span 97 100)))\n (:hscopes ((:id . :x2.90.2) (:span 0 112)))\n (:nscopes ((:id . :x2.90.1) (:span 97 112)))\n (:identifiers (:sid . :s2.90) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100417@unknown@formal@none@1@S@Estimates for the prior odds ratio of interaction vary.@(((:tag . "NNS") (:stem . "estimate") (:form . "Estimates") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "vary") (:form . "vary") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s2.91) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100418@unknown@formal@none@1@S@Previous interaction studies on yeast and human use prior odds ratios that range from 1/600 to > 1/400 37434647.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "range") (:form . "range") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1/600") (:form . "1/600") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1/400") (:form . "1/400") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "CD") (:stem . "37434647") (:form . "37434647") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.92) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100420@unknown@formal@none@1@S@As detailed in Methods, the prior odds ratio for human protein interaction was explored by considering different versions and subsets of human interaction datasets.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "detail") (:form . "detailed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Method") (:form . "Methods") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 74)\n  (:start . 63) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 112)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "version") (:form . "versions") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.94) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100421@unknown@formal@none@1@S@This suggested that there is insufficient data currently available to determine a reliable ratio for human.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "reliable") (:form . "reliable") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x2.95.1) (:span 5 14)))\n (:hscopes ((:id . :x2.95.1) (:span 5 106)))\n (:identifiers (:sid . :s2.95) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100422@unknown@formal@none@1@S@Accordingly, we selected a prior odds ratio of interaction of 1/400 which is similar to current estimates for yeast and is probably still quite conservative.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "select") (:form . "selected") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 58)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1/400") (:form . "1/400") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 115)\n  (:start . 110) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "JJ") (:stem . "conservative") (:form . "conservative") (:end . 156)\n  (:start . 144) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x2.96.1) (:span 123 131)))\n (:hscopes ((:id . :x2.96.1) (:span 123 156)))\n (:identifiers (:sid . :s2.96) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100423@unknown@formal@none@1@S@Thus, the likelihood ratio threshold to predict interactions is 400.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.97) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100424@unknown@formal@none@1@S@Likelihood ratios of the modules@(((:tag . "NN") (:stem . "likelihood") (:form . "Likelihood") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 32)\n  (:start . 25) (:id . 46)))@@@1@5@((:identifiers (:sid . :s2.98) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100425@unknown@formal@none@1@S@Figure 1 summarizes the likelihood ratios computed for the five modules.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "summarize") (:form . "summarizes") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.99) (:did . :1471-2105-8-239) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100426@unknown@formal@none@1@S@The different modules differ in the range of likelihood ratio values achieved by their different states.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.100) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100427@unknown@formal@none@1@S@The Orthology and Combined modules both have states that achieve likelihood ratios above 400 (as high as 1207 for the Orthology module and 613 for the Combined module), indicating that both these modules can, on their own, predict some interacting protein pairs with a posterior odds ratio above 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1207") (:form . "1207") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "CD") (:stem . "613") (:form . "613") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "combined") (:form . "Combined") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 179)\n  (:start . 169) (:id . 73))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 184) (:start . 180)\n  (:id . 74))\n ((:tag . "PDT") (:stem . "both") (:form . "both") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 195)\n  (:start . 190) (:id . 76))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 203)\n  (:start . 196) (:id . 77))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 79))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 211) (:start . 209)\n  (:id . 80))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 217)\n  (:start . 212) (:id . 81))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 221) (:start . 218)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 83))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 230)\n  (:start . 223) (:id . 84))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 235) (:start . 231)\n  (:id . 85))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 247)\n  (:start . 236) (:id . 86))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 255)\n  (:start . 248) (:id . 87))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 261)\n  (:start . 256) (:id . 88))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 266) (:start . 262)\n  (:id . 89))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 268) (:start . 267)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 278)\n  (:start . 269) (:id . 91))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 283) (:start . 279)\n  (:id . 92))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 289)\n  (:start . 284) (:id . 93))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 295)\n  (:start . 290) (:id . 94))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 297) (:start . 296)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 298) (:start . 297)\n  (:id . 96)))@@@1@55@((:hcues ((:id . :x2.101.1) (:span 204 207))\n  ((:id . :x2.101.2) (:span 169 184)))\n (:hscopes ((:id . :x2.101.1) (:span 204 297))\n  ((:id . :x2.101.2) (:span 169 297)))\n (:identifiers (:sid . :s2.101) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100428@unknown@formal@none@1@S@The Expression module follows trends seen in previous studies with increasing likelihood ratios of interaction reflecting increasing expression correlation 3746.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "trend") (:form . "trends") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 110)\n  (:start . 99) (:id . 56))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 121)\n  (:start . 111) (:id . 57))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 132)\n  (:start . 122) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 143)\n  (:start . 133) (:id . 59))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 155)\n  (:start . 144) (:id . 60))\n ((:tag . "CD") (:stem . "3746") (:form . "3746") (:end . 160) (:start . 156)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.102) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100430@unknown@formal@none@1@S@Similarly, but in a much more pronounced way, the Disorder module is only slightly predictive of interaction, with a maximum likelihood ratio of 1.8.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pronounced") (:form . "pronounced") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 124)\n  (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 135)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "CD") (:stem . "1.8") (:form . "1.8") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.104) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100431@unknown@formal@none@1@S@Most states of the Orthology module achieve higher likelihood ratios than the highest obtained by the Expression and Disorder modules.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 50) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.105) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100432@unknown@formal@none@1@S@This is not surprising as the transfer of interacting orthologs (known as interologs 33) from one organism to another is a popular method to predict interactions (see for example 3448), particularly in the case of organisms like human for which only a small proportion of interactions are known.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "surprising") (:form . "surprising") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "interolog") (:form . "interologs") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . 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5100433@unknown@formal@none@1@S@The direct transfer of interactions to human from either yeast, fly or worm does not alone result in a posterior odds ratio above 1 (as the likelihood ratios of interaction for all yeast, fly and worm bins in the Orthology module are below 400).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . 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5100434@unknown@formal@none@1@S@This is not surprising as previous studies have indicated that quite stringent joint E-values must be used to transfer interactions safely between organisms 3435.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "surprising") (:form . "surprising") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "stringent") (:form . "stringent") (:end . 78)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "joint") (:form . "joint") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "e-value") (:form . "E-values") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "VB") (:stem . "transfer") (:form . "transfer") (:end . 118)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 131)\n  (:start . 119) (:id . 61))\n ((:tag . "RB") (:stem . "safely") (:form . "safely") (:end . 138)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 146)\n  (:start . 139) (:id . 63))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 156)\n  (:start . 147) (:id . 64))\n ((:tag . "CD") (:stem . "3435") (:form . "3435") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.108.1) (:span 48 62)))\n (:ncues ((:id . :x2.108.2) (:span 8 11)))\n (:hscopes ((:id . :x2.108.1) (:span 48 156)))\n (:nscopes ((:id . :x2.108.2) (:span 8 22)))\n (:identifiers (:sid . :s2.108) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100435@unknown@formal@none@1@S@In contrast, the consideration of human interactions paralogous to the human protein pairs under investigation results in likelihood ratios of 431 and 1034 (depending on how close the paralogs are as described in Methods) which is much higher than those obtained for any single model organism.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "consideration") (:form . "consideration")\n  (:end . 30) (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . 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"model") (:end . 283)\n  (:start . 278) (:id . 89))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 292)\n  (:start . 284) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s2.109) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100436@unknown@formal@none@1@S@This agrees with a recent report that suggested protein-protein interactions are more conserved within species than across species 49.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "agree") (:form . "agrees") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 63) (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 76)\n  (:start . 64) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "CD") (:stem . "49") (:form . "49") (:end . 133) (:start . 131)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x2.110.1) (:span 38 47)))\n (:hscopes ((:id . :x2.110.1) (:span 38 130)))\n (:identifiers (:sid . :s2.110) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100437@unknown@formal@none@1@S@The Combined module uses domain co-occurrence, post-translational modification (PTM) co-occurrence and subcellular localization information to predict interaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 45) (:start . 32) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "post-translational") (:form . "post-translational")\n  (:end . 65) (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 78)\n  (:start . 66) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 83) (:start . 80)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 53))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 98) (:start . 85) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 127)\n  (:start . 115) (:id . 57))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 139)\n  (:start . 128) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 59))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 150)\n  (:start . 143) (:id . 60))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 162)\n  (:start . 151) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.111) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100438@unknown@formal@none@1@S@These features were originally investigated separately, as shown in Figure 3, but their combination into one module that considers all dependencies between them achieves higher accuracy (data not shown) and higher likelihood ratios (as can be seen by comparing to Figure 1) while still being computationally feasible.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 54)\n  (:start . 44) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 87)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 99)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "dependency") (:form . "dependencies") (:end . 147)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 160) (:start . 156)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 169)\n  (:start . 161) (:id . 67))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 176)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 185)\n  (:start . 177) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 191)\n  (:start . 187) (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 195) (:start . 192)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 201)\n  (:start . 196) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 213)\n  (:start . 207) (:id . 76))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 224)\n  (:start . 214) (:id . 77))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 79))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 235) (:start . 233)\n  (:id . 80))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 239) (:start . 236)\n  (:id . 81))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 242) (:start . 240)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 247) (:start . 243)\n  (:id . 83))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 250) (:start . 248)\n  (:id . 84))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 260)\n  (:start . 251) (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 263) (:start . 261)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 270)\n  (:start . 264) (:id . 87))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 272) (:start . 271)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 273) (:start . 272)\n  (:id . 89))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 279)\n  (:start . 274) (:id . 90))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 285)\n  (:start . 280) (:id . 91))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 291) (:start . 286)\n  (:id . 92))\n ((:tag . "RB") (:stem . "computationally") (:form . "computationally")\n  (:end . 307) (:start . 292) (:id . 93))\n ((:tag . "JJ") (:stem . "feasible") (:form . "feasible") (:end . 316)\n  (:start . 308) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 317) (:start . 316)\n  (:id . 95)))@@@1@54@((:ncues ((:id . :x2.112.1) (:span 192 195)))\n (:nscopes ((:id . :x2.112.1) (:span 186 202)))\n (:identifiers (:sid . :s2.112) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100440@unknown@formal@none@1@S@Likelihood ratios of the features that form the Combined module, considered separately@(((:tag . "NN") (:stem . "likelihood") (:form . "Likelihood") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 86)\n  (:start . 76) (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.114) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100441@unknown@formal@none@1@S@Likelihood ratios of the features that form the Combined module, considered separately.@(((:tag . "NN") (:stem . "likelihood") (:form . "Likelihood") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.115) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100442@unknown@formal@none@1@S@The Combined module considers simultaneously three distinct features: the co-occurrence of both domains and PTMs as well as the subcellular co-localization of proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 44) (:start . 30) (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 50) (:start . 45)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 59)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 68)\n  (:start . 60) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 69) (:start . 68)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 87) (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 53))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 95) (:start . 91)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "ptm") (:form . "PTMs") (:end . 112) (:start . 108)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . "NN") (:stem . "co-localization") (:form . "co-localization")\n  (:end . 155) (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.116) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100443@unknown@formal@none@1@S@Here the likelihood ratios of these features considered separately are shown.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.117) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100444@unknown@formal@none@1@S@In panel A, all domain pairs considered were given scores and likelihood ratios were estimated for different values of these scores.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 22)\n  (:start . 16) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 39)\n  (:start . 29) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.118) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100445@unknown@formal@none@1@S@Similarly, shown in panel B are the likelihood ratios for different values of PTM co-occurrence scores.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 46)\n  (:start . 36) (:id . 50))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 67)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 95) (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.119) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100446@unknown@formal@none@1@S@Panel C shows the likelihood ratios for protein pairs localized to different sets of cellular compartments.@(((:tag . "NN") (:stem . "panel") (:form . "Panel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "localize") (:form . "localized") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.120) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100447@unknown@formal@none@1@S@Previous methods have investigated the use of co-occurring domains to predict interaction (see for example 2346).@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "co-occurre") (:form . "co-occurring") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . "CD") (:stem . "2346") (:form . "2346") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.121) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100448@unknown@formal@none@1@S@Many pairs of domains co-occur in proteins known to interact.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "co-occur") (:form . "co-occur") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s2.122) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100450@unknown@formal@none@1@S@Similarly, the co-occurrence of PTMs is also predictive of interaction, with its highest scoring bin obtaining a likelihood ratio of 6 as shown in Figure 3B.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTMs") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "obtain") (:form . "obtaining") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 123)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "3b") (:form . "3B") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.124) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100451@unknown@formal@none@1@S@Lists of high scoring domain pairs and PTM pairs are shown in Additional Files 1 and 2.@(((:tag . "NNS") (:stem . "list") (:form . "Lists") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ptm") (:form . "PTM") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "NNP") (:stem . "File") (:form . "Files") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.125) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100452@unknown@formal@none@1@S@Subcellular localization has been extensively used both to assess the quality of interaction datasets 115051 and to generate examples of non-interacting protein pairs to use as negative datasets when training and testing predictors 3746.@(((:tag . "JJ") (:stem . "subcellular") (:form . "Subcellular") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 55) (:start . 51)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 92)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "CD") (:stem . "115051") (:form . "115051") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 58))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 133)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 152) (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 160)\n  (:start . 153) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 166)\n  (:start . 161) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 65))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 185)\n  (:start . 177) (:id . 68))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 194)\n  (:start . 186) (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 199) (:start . 195)\n  (:id . 70))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 208)\n  (:start . 200) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 72))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 220)\n  (:start . 213) (:id . 73))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 231)\n  (:start . 221) (:id . 74))\n ((:tag . "CD") (:stem . "3746") (:form . "3746") (:end . 236) (:start . 232)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.126) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100453@unknown@formal@none@1@S@In the present study, the use of localization was investigated as a feature predictive of interaction.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 45)\n  (:start . 33) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 62)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 86)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.127) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100454@unknown@formal@none@1@S@Four possible localization states were considered for protein pairs:: same compartment, neighboring compartments, different non-neighboring compartments and absence of localization annotation (more details are given in the Methods section).@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 33)\n  (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 99)\n  (:start . 88) (:id . 56))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 112)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "non-neighboring") (:form . "non-neighboring")\n  (:end . 139) (:start . 124) (:id . 60))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 152)\n  (:start . 140) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 62))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 164)\n  (:start . 157) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 180)\n  (:start . 168) (:id . 65))\n ((:tag . "NN") (:stem . "annotation") (:form . "annotation") (:end . 191)\n  (:start . 181) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 193) (:start . 192)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 197) (:start . 193)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 205)\n  (:start . 198) (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 215)\n  (:start . 210) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Method") (:form . "Methods") (:end . 230)\n  (:start . 223) (:id . 74))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 238)\n  (:start . 231) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 239) (:start . 238)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x2.128.2) (:span 5 13)))\n (:ncues ((:id . :x2.128.1) (:span 157 164)))\n (:hscopes ((:id . :x2.128.2) (:span 5 33)))\n (:nscopes ((:id . :x2.128.1) (:span 157 191)))\n (:identifiers (:sid . :s2.128) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100455@unknown@formal@none@1@S@As shown in Figure 3C, the likelihood ratio of same compartment protein pairs was found to be twice as high as that of randomly chosen or non-annotated protein pairs whereas different non-neighboring protein pairs are more than three times less likely to interact than random protein pairs.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "3c") (:form . "3C") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "likelihood") (:form . 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"RB") (:stem . "twice") (:form . "twice") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 107) (:start . 103)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 65))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 127)\n  (:start . 119) (:id . 66))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 134)\n  (:start . 128) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 137) (:start . 135)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "non-annotated") (:form . "non-annotated")\n  (:end . 151) (:start . 138) (:id . 69))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 159)\n  (:start . 152) (:id . 70))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 165)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 173)\n  (:start . 166) (:id . 72))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 183)\n  (:start . 174) (:id . 73))\n ((:tag . "JJ") (:stem . "non-neighboring") (:form . "non-neighboring")\n  (:end . 199) (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 207)\n  (:start . 200) (:id . 75))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 213)\n  (:start . 208) (:id . 76))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 217) (:start . 214)\n  (:id . 77))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 222) (:start . 218)\n  (:id . 78))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 227) (:start . 223)\n  (:id . 79))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 233)\n  (:start . 228) (:id . 80))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 239)\n  (:start . 234) (:id . 81))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 244) (:start . 240)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 251)\n  (:start . 245) (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 254) (:start . 252)\n  (:id . 84))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 263)\n  (:start . 255) (:id . 85))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 268) (:start . 264)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 275)\n  (:start . 269) (:id . 87))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 283)\n  (:start . 276) (:id . 88))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 289)\n  (:start . 284) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s2.129) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100456@unknown@formal@none@1@S@Individual localization features achieve low interaction likelihood ratios.@(((:tag . "JJ") (:stem . "individual") (:form . "Individual") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 23)\n  (:start . 11) (:id . 43))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 32)\n  (:start . 24) (:id . 44))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 40)\n  (:start . 33) (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 44) (:start . 41)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 56)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 67)\n  (:start . 57) (:id . 48))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 74)\n  (:start . 68) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.130) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100457@unknown@formal@none@1@S@However, when integrated into the Combined module, domain, PTM and localization information together achieve likelihood ratios that are high enough to predict interaction on their own (i.e. above 400).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 79)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 65))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 170)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 179)\n  (:start . 174) (:id . 69))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 189) (:start . 185)\n  (:id . 72))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 195)\n  (:start . 190) (:id . 73))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.131) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100458@unknown@formal@none@1@S@As expected, the highest likelihood ratio bins for the Combined module are those representing the highest combinations of the three features separately.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 118)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 151)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.132) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100460@unknown@formal@none@1@S@The likelihood ratios for different values of the neighborhood topology score are shown in Figure 1B.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "neighborhood") (:form . "neighborhood") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.134) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100461@unknown@formal@none@1@S@The Transitive module is highly predictive of interaction and achieves likelihood ratios as high as 229.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 57)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 81)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 88)\n  (:start . 82) (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 96) (:start . 92)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "CD") (:stem . "229") (:form . "229") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.135) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100462@unknown@formal@none@1@S@This module cannot be used alone as it requires as input the output of at least one group A module.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "input") (:form . "input") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 98)\n  (:start . 92) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x2.136.1) (:span 12 18)))\n (:nscopes ((:id . :x2.136.1) (:span 0 32)))\n (:identifiers (:sid . :s2.136) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100463@unknown@formal@none@1@S@However, it can predict interacting protein pairs with a posterior odds ratio above 1.0 when used in combination with any single module in group A (as the product of the highest likelihood ratios of the transitive module and any group A module is greater than 400 as can be seen from Figure 1).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 112)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 128)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 135)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 146) (:start . 145)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 162)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 73))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 177)\n  (:start . 170) (:id . 74))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 188)\n  (:start . 178) (:id . 75))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 195)\n  (:start . 189) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 213)\n  (:start . 203) (:id . 79))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 220)\n  (:start . 214) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 81))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 228) (:start . 225)\n  (:id . 82))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 234)\n  (:start . 229) (:id . 83))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 236) (:start . 235)\n  (:id . 84))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 243)\n  (:start . 237) (:id . 85))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 246) (:start . 244)\n  (:id . 86))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 254)\n  (:start . 247) (:id . 87))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 259) (:start . 255)\n  (:id . 88))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 263) (:start . 260)\n  (:id . 89))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 266) (:start . 264)\n  (:id . 90))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 270) (:start . 267)\n  (:id . 91))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 273) (:start . 271)\n  (:id . 92))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 278) (:start . 274)\n  (:id . 93))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 283) (:start . 279)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 290)\n  (:start . 284) (:id . 95))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 292) (:start . 291)\n  (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 293) (:start . 292)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 294) (:start . 293)\n  (:id . 98)))@@@1@57@((:hcues ((:id . :x2.137.1) (:span 16 23)))\n (:hscopes ((:id . :x2.137.1) (:span 16 146)))\n (:identifiers (:sid . :s2.137) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100464@unknown@formal@none@1@S@Independence of the modules@(((:tag . "NN") (:stem . "independence") (:form . "Independence") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 27)\n  (:start . 20) (:id . 45)))@@@1@4@((:identifiers (:sid . :s2.138) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100465@unknown@formal@none@1@S@The final likelihood ratio output by the predictor is only representative of the true likelihood of interaction of a protein pair if the modules considered are independent.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "representative") (:form . "representative")\n  (:end . 73) (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 155)\n  (:start . 145) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 171)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.139) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100466@unknown@formal@none@1@S@If the modules were not independent, some likelihood ratios would likely be overestimated, particularly for protein pairs that achieve simultaneously high likelihoods for non-independent features.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "overestimate") (:form . "overestimated")\n  (:end . 89) (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 103)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 149) (:start . 135) (:id . 63))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 154) (:start . 150)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "likelihood") (:form . "likelihoods") (:end . 166)\n  (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "non-independent") (:form . "non-independent")\n  (:end . 186) (:start . 171) (:id . 67))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 195)\n  (:start . 187) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x2.140.1) (:span 60 65 66 72)))\n (:ncues ((:id . :x2.140.3) (:span 20 23)))\n (:hscopes ((:id . :x2.140.1) (:span 37 195)))\n (:nscopes ((:id . :x2.140.3) (:span 20 35)))\n (:identifiers (:sid . :s2.140) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100467@unknown@formal@none@1@S@Conversely, some likelihood ratios would be underestimated for protein pairs achieving simultaneously low likelihoods for non-independent features.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "underestimate") (:form . "underestimated")\n  (:end . 58) (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "achieve") (:form . "achieving") (:end . 86)\n  (:start . 77) (:id . 53))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 101) (:start . 87) (:id . 54))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 105) (:start . 102)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "likelihood") (:form . "likelihoods") (:end . 117)\n  (:start . 106) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 121) (:start . 118)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "non-independent") (:form . "non-independent")\n  (:end . 137) (:start . 122) (:id . 58))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 146)\n  (:start . 138) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x2.141.1) (:span 35 40)))\n (:hscopes ((:id . :x2.141.1) (:span 12 146)))\n (:identifiers (:sid . :s2.141) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100468@unknown@formal@none@1@S@Previous studies have demonstrated that some of the features considered here are indeed independent 43.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "RB") (:stem . "indeed") (:form . "indeed") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 99)\n  (:start . 88) (:id . 55))\n ((:tag . "CD") (:stem . "43") (:form . "43") (:end . 102) (:start . 100)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.142) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100470@unknown@formal@none@1@S@As shown in Table 2, all modules considered are independent, since the highest Pearson correlation coefficients computed are well below any value considered significant.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 24) (:start . 21)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 32)\n  (:start . 25) (:id . 49))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 43)\n  (:start . 33) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 59)\n  (:start . 48) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "NNP") (:stem . "Pearson") (:form . "Pearson") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 98)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "coefficient") (:form . "coefficients") (:end . 111)\n  (:start . 99) (:id . 59))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 168)\n  (:start . 157) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s2.144) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100471@unknown@formal@none@1@S@Pairwise Pearson correlation for all modules@(((:tag . "NNP") (:stem . "Pairwise") (:form . "Pairwise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Pearson") (:form . "Pearson") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 44)\n  (:start . 37) (:id . 47)))@@@1@6@((:identifiers (:sid . :s2.145) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5100472@unknown@formal@none@1@S@Accuracy of the predictors@(((:tag . "NN") (:stem . "accuracy") (:form . "Accuracy") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 26)\n  (:start . 16) (:id . 45)))@@@1@4@((:identifiers (:sid . :s2.146) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100473@unknown@formal@none@1@S@All combinations of modules were examined to determine which of the resulting predictors achieved the highest prediction accuracy.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . "VBD") (:stem . "achieve") (:form . "achieved") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 120)\n  (:start . 110) (:id . 58))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 129)\n  (:start . 121) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.147) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100474@unknown@formal@none@1@S@In order to analyze the predictions, five-fold cross validation experiments were performed and the area under partial ROC (receiver operator characteristic) curves (partial AUCs) measured.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "cross") (:form . "cross") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 103) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 109)\n  (:start . 104) (:id . 58))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 117)\n  (:start . 110) (:id . 59))\n ((:tag . "NNP") (:stem . "ROC") (:form . "ROC") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "receiver") (:form . "receiver") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "operator") (:form . "operator") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 155) (:start . 141) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 163)\n  (:start . 157) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 172)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "auc") (:form . "AUCs") (:end . 177) (:start . 173)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 187)\n  (:start . 179) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s2.148) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100475@unknown@formal@none@1@S@ROC50 and ROC100 curves were selected as they consider a large enough number of positives to include all protein pairs predicted to have a posterior odds ratio above 1.0 by all the predictors investigated.@(((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ROC100") (:form . "ROC100") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "enough") (:form . "enough") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 57))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 191)\n  (:start . 181) (:id . 74))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 204)\n  (:start . 192) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x2.149.1) (:span 119 128)))\n (:hscopes ((:id . :x2.149.1) (:span 101 204)))\n (:identifiers (:sid . :s2.149) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100476@unknown@formal@none@1@S@Protein pairs predicted to have a posterior odds ratio below 1.0 have an estimated true positive rate below 50% and thus are more likely not to interact than to interact.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 136)\n  (:start . 130) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 152)\n  (:start . 144) (:id . 69))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 169)\n  (:start . 161) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x2.150.2) (:span 130 136)))\n (:ncues ((:id . :x2.150.1) (:span 137 140)))\n (:hscopes ((:id . :x2.150.2) (:span 121 169)))\n (:nscopes ((:id . :x2.150.1) (:span 137 152)))\n (:identifiers (:sid . :s2.150) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100477@unknown@formal@none@1@S@These protein pairs are therefore not of interest in this context.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x2.151.1) (:span 34 37)))\n (:nscopes ((:id . :x2.151.1) (:span 34 65)))\n (:identifiers (:sid . :s2.151) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100478@unknown@formal@none@1@S@The area under all ROCn curves considered is relatively low because of the high proportion of negatives with respect to positives in the training and test sets (100:1).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ROCn") (:form . "ROCn") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 145)\n  (:start . 137) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 66))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 69))\n ((:tag . "CD") (:stem . "100:1") (:form . "100:1") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s2.152) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100480@unknown@formal@none@1@S@Individual modules do not achieve high scores for the areas under the ROC50 and ROC100.@(((:tag . "JJ") (:stem . "individual") (:form . "Individual") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ROC100") (:form . "ROC100") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x2.154.1) (:span 22 25)))\n (:nscopes ((:id . :x2.154.1) (:span 22 86)))\n (:identifiers (:sid . :s2.154) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100481@unknown@formal@none@1@S@In fact, all ROC50 AUC values achieved by individual modules are below 0.025 and the Expression and Disorder modules do not predict any protein pairs (positive or negative) above a posterior odds ratio of 1, which is expected as the highest likelihood ratios they achieve are lower than 400 (see Figure 1A).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 18) (:start . 13)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "VBN") (:stem . 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(:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 100)))@@@1@59@((:hcues ((:id . :x2.155.1) (:span 160 162)))\n (:ncues ((:id . :x2.155.2) (:span 120 123)))\n (:hscopes ((:id . :x2.155.1) (:span 150 172)))\n (:nscopes ((:id . :x2.155.2) (:span 120 206)))\n (:identifiers (:sid . :s2.155) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100482@unknown@formal@none@1@S@As more Group A modules are considered within the same predictor, the ROCn AUC scores increase significantly, as would be expected since these features are independent (as shown in Table 2) and thus contribute different information to the prediction.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ROCn") (:form . "ROCn") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "VBP") (:stem . "increase") (:form . "increase") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 108) (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 136)\n  (:start . 131) (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 167)\n  (:start . 156) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 177)\n  (:start . 172) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 186)\n  (:start . 181) (:id . 74))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 77))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 198) (:start . 194)\n  (:id . 78))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 209)\n  (:start . 199) (:id . 79))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 219)\n  (:start . 210) (:id . 80))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 231)\n  (:start . 220) (:id . 81))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 234) (:start . 232)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 83))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 249)\n  (:start . 239) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x2.156.1) (:span 113 118)))\n (:hscopes ((:id . :x2.156.1) (:span 113 130)))\n (:identifiers (:sid . :s2.156) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100483@unknown@formal@none@1@S@For example, the predictor that considers both the Expression and Combined modules achieves a ROC50 AUC of 0.033 compared to 0.003 and 0.022 respectively for the individual modules.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "CD") (:stem . "0.033") (:form . "0.033") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.003") (:form . "0.003") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "CD") (:stem . "0.022") (:form . "0.022") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 153)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 172)\n  (:start . 162) (:id . 69))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 180)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.157) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100484@unknown@formal@none@1@S@However, the Disorder module does not contribute significantly to the prediction as predictors that consider it do not, in general, do better than their counterparts that do not use it.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 130)\n  (:start . 123) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "RBR") (:stem . "well") (:form . "better") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "NNS") (:stem . "counterpart") (:form . "counterparts") (:end . 165)\n  (:start . 153) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 170) (:start . 166)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 177) (:start . 174)\n  (:id . 72))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x2.158.1) (:span 174 177))\n  ((:id . :x2.158.2) (:span 115 118)))\n (:nscopes ((:id . :x2.158.1) (:span 174 184))\n  ((:id . :x2.158.2) (:span 115 184)))\n (:identifiers (:sid . :s2.158) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100485@unknown@formal@none@1@S@For example, both the Expression-Orthology predictor and the Expression-Orthology-Disorder predictor achieve a ROC50 AUC of 0.024.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Expression-Orthology")\n  (:form . "Expression-Orthology") (:end . 42) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Expression-Orthology-Disorder")\n  (:form . "Expression-Orthology-Disorder") (:end . 90) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 100)\n  (:start . 91) (:id . 52))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 108)\n  (:start . 101) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 116)\n  (:start . 111) (:id . 55))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 120) (:start . 117)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 57))\n ((:tag . "CD") (:stem . "0.024") (:form . "0.024") (:end . 129)\n  (:start . 124) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.159) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100486@unknown@formal@none@1@S@The Disorder module offers the advantage of increasing the coverage of the prediction as a disorder score is calculated for all protein pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "offer") (:form . "offers") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 119)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 141)\n  (:start . 136) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.160) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100487@unknown@formal@none@1@S@However, this appears to add more noise to the prediction without increasing the accuracy.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VB") (:stem . "add") (:form . "add") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "noise") (:form . "noise") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x2.161.2) (:span 14 21)))\n (:ncues ((:id . :x2.161.1) (:span 58 65)))\n (:hscopes ((:id . :x2.161.2) (:span 9 89)))\n (:nscopes ((:id . :x2.161.1) (:span 58 89)))\n (:identifiers (:sid . :s2.161) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100488@unknown@formal@none@1@S@Prediction accuracy of different combinations of modules@(((:tag . "NN") (:stem . "prediction") (:form . "Prediction") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 45)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 56)\n  (:start . 49) (:id . 48)))@@@1@7@((:identifiers (:sid . :s2.162) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5100490@unknown@formal@none@1@S@For example, the Expression-Orthology predictor achieves a ROC50 AUC of 0.024 and predicts 5670 interactions at a posterior odds ratio greater than 1 whereas the Expression-Orthology-Combined predictor achieves a ROC50 AUC of 0.044 and predicts over 15000 interactions at a posterior odds ratio above 1.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Expression-Orthology")\n  (:form . "Expression-Orthology") (:end . 37) (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0.024") (:form . "0.024") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "CD") (:stem . "5670") (:form . "5670") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 108)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 147) (:start . 143)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "expression-orthology-combined")\n  (:form . "Expression-Orthology-Combined") (:end . 191) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 201)\n  (:start . 192) (:id . 69))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 210)\n  (:start . 202) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 212) (:start . 211)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 218)\n  (:start . 213) (:id . 72))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 222) (:start . 219)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 225) (:start . 223)\n  (:id . 74))\n ((:tag . "CD") (:stem . "0.044") (:form . "0.044") (:end . 231)\n  (:start . 226) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 244)\n  (:start . 236) (:id . 77))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 249) (:start . 245)\n  (:id . 78))\n ((:tag . "CD") (:stem . "15000") (:form . "15000") (:end . 255)\n  (:start . 250) (:id . 79))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 268)\n  (:start . 256) (:id . 80))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 271) (:start . 269)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 273) (:start . 272)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 283)\n  (:start . 274) (:id . 83))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 288) (:start . 284)\n  (:id . 84))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 294)\n  (:start . 289) (:id . 85))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 300)\n  (:start . 295) (:id . 86))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 302) (:start . 301)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 303) (:start . 302)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s2.164) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100491@unknown@formal@none@1@S@The best combination of Group A modules is the predictor consisting of the Expression, Orthology and Combined modules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.165) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100492@unknown@formal@none@1@S@The Transitive module, which can only be used in combination with other modules, increases substantially the scores and number of interactions predicted.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 60)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 104) (:start . 91) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 142)\n  (:start . 130) (:id . 64))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.166) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100493@unknown@formal@none@1@S@The right-hand portion of Table 3 shows the accuracy measures for the highest scoring subset of predictors that consider the Transitive module.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "right-hand") (:form . "right-hand") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "show") (:form . "shows") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 135)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.167) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100494@unknown@formal@none@1@S@The Transitive module enhances the prediction by identifying among protein pairs with a relatively high preliminary score those that are most likely to interact, by considering the local topology of the network around them.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "enhance") (:form . "enhances") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 66) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 98)\n  (:start . 88) (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 103) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 115)\n  (:start . 104) (:id . 57))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 121)\n  (:start . 116) (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 132) (:start . 128)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 176)\n  (:start . 165) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 210)\n  (:start . 203) (:id . 74))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 217)\n  (:start . 211) (:id . 75))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x2.168.1) (:span 142 148)))\n (:hscopes ((:id . :x2.168.1) (:span 128 160)))\n (:identifiers (:sid . :s2.168) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100495@unknown@formal@none@1@S@For example, the ROC50 AUC rises from 0.044 to 0.075 when the Transitive module is added to the Expression-Orthology-Combined predictor, and the number of predictions above a posterior odds ratio of 1 doubles from 15330 to 34780.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "rise") (:form . "rises") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.044") (:form . "0.044") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "CD") (:stem . "0.075") (:form . "0.075") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 72)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "expression-orthology-combined")\n  (:form . "Expression-Orthology-Combined") (:end . 125) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 166)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 184)\n  (:start . 175) (:id . 71))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 189) (:start . 185)\n  (:id . 72))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 195)\n  (:start . 190) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 74))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 200) (:start . 199)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "double") (:form . "doubles") (:end . 208)\n  (:start . 201) (:id . 76))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 213) (:start . 209)\n  (:id . 77))\n ((:tag . "CD") (:stem . "15330") (:form . "15330") (:end . 219)\n  (:start . 214) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 222) (:start . 220)\n  (:id . 79))\n ((:tag . "CD") (:stem . "34780") (:form . "34780") (:end . 228)\n  (:start . 223) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s2.169) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100496@unknown@formal@none@1@S@Once again, the Disorder module does not contribute positively to the prediction.@(((:tag . "RB") (:stem . "once") (:form . "Once") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VB") (:stem . "contribute") (:form . "contribute") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x2.170.1) (:span 37 40)))\n (:nscopes ((:id . :x2.170.1) (:span 37 80)))\n (:identifiers (:sid . :s2.170) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100497@unknown@formal@none@1@S@Its inclusion does not increase any of the measures of accuracy considered.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inclusion") (:form . "inclusion") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x2.171.1) (:span 19 22)))\n (:nscopes ((:id . :x2.171.1) (:span 19 74)))\n (:identifiers (:sid . :s2.171) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100498@unknown@formal@none@1@S@The predictor that considers the Expression, Orthology, Combined and Transitive modules is the one that achieves the highest accuracy overall.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 64)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "one") (:form . "one") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 133)\n  (:start . 125) (:id . 62))\n ((:tag . "RB") (:stem . "overall") (:form . "overall") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.172) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100500@unknown@formal@none@1@S@Comparison to predictions generated using alternative training sets@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 41) (:start . 36)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 53)\n  (:start . 42) (:id . 47))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 62)\n  (:start . 54) (:id . 48))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 67) (:start . 63)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.174) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100501@unknown@formal@none@1@S@In this work training sets were used that comprised 100 times more negatives than positives, with the negatives randomly selected and filtered to remove any known or suspected positives (see Methods).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "comprise") (:form . "comprised") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 129)\n  (:start . 121) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "VB") (:stem . "remove") (:form . "remove") (:end . 152)\n  (:start . 146) (:id . 66))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "suspect") (:form . "suspected") (:end . 175)\n  (:start . 166) (:id . 70))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 185)\n  (:start . 176) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 190) (:start . 187)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 198)\n  (:start . 191) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x2.175.1) (:span 166 175)))\n (:hscopes ((:id . :x2.175.1) (:span 166 185)))\n (:identifiers (:sid . :s2.175) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100502@unknown@formal@none@1@S@Other groups have used negative:positive ratios ranging from 1 to more than 600 (see for example 374752).@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "negative:positive") (:form . "negative:positive")\n  (:end . 40) (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 55)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 62) (:start . 61)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "600") (:form . "600") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "CD") (:stem . "374752") (:form . "374752") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.176) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100503@unknown@formal@none@1@S@In addition, several groups use localization-derived negatives (i.e. protein pairs that are not annotated as being localized to the same cellular compartment) rather than randomly chosen negatives (see for example 374346).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 52) (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 105)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 114) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 157)\n  (:start . 146) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 165)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 170) (:start . 166)\n  (:id . 68))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 179)\n  (:start . 171) (:id . 69))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 186)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 196)\n  (:start . 187) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 72))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 205) (:start . 202)\n  (:id . 74))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 213)\n  (:start . 206) (:id . 75))\n ((:tag . "CD") (:stem . "374346") (:form . "374346") (:end . 220)\n  (:start . 214) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 221) (:start . 220)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x2.177.1) (:span 159 170))\n  ((:id . :x2.177.2) (:span 92 95)))\n (:nscopes ((:id . :x2.177.1) (:span 159 196))\n  ((:id . :x2.177.2) (:span 83 157)))\n (:identifiers (:sid . :s2.177) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100504@unknown@formal@none@1@S@These issues have been investigated previously 53.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "issue") (:form . "issues") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 46)\n  (:start . 36) (:id . 47))\n ((:tag . "CD") (:stem . "53") (:form . "53") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.178) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100505@unknown@formal@none@1@S@Since the choice of negative training data may influence the method, the choice of different training sets in the context of the probabilistic predictor presented here was investigated to determine which type of training set offers the highest accuracy.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "choice") (:form . "choice") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "choice") (:form . "choice") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 142) (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 152)\n  (:start . 143) (:id . 66))\n ((:tag . "VBN") (:stem . "present") (:form . "presented") (:end . 162)\n  (:start . 153) (:id . 67))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 171) (:start . 168)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 184)\n  (:start . 172) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 197)\n  (:start . 188) (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 203)\n  (:start . 198) (:id . 73))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 208) (:start . 204)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 75))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 220)\n  (:start . 212) (:id . 76))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 224) (:start . 221)\n  (:id . 77))\n ((:tag . "VBZ") (:stem . "offer") (:form . "offers") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 79))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 243)\n  (:start . 236) (:id . 80))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 252)\n  (:start . 244) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x2.179.1) (:span 43 46)))\n (:hscopes ((:id . :x2.179.1) (:span 43 67)))\n (:identifiers (:sid . :s2.179) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100506@unknown@formal@none@1@S@Table 4 compares the accuracy of predictors trained with negative:positive ratios of 1:100 and 1:1 and tested by five-fold cross validation.@(((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "compare") (:form . "compares") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative:positive") (:form . "negative:positive")\n  (:end . 74) (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 81)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1:100") (:form . "1:100") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "CD") (:stem . "1:1") (:form . "1:1") (:end . 98) (:start . 95)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "cross") (:form . "cross") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.180) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100507@unknown@formal@none@1@S@Ratios greater than 100 were not considered because they are computationally infeasible given the size of our datasets and the architecture of the predictor.@(((:tag . "NNS") (:stem . "ratio") (:form . "Ratios") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "computationally") (:form . "computationally")\n  (:end . 76) (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "infeasible") (:form . "infeasible") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "architecture") (:form . "architecture") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 156)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x2.181.1) (:span 29 32)))\n (:nscopes ((:id . :x2.181.1) (:span 0 43)))\n (:identifiers (:sid . :s2.181) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100508@unknown@formal@none@1@S@To perform such a comparison, the EOCT predictor (Expression, Orthology, Combined and Transitive modules) was trained on datasets consisting of either equal numbers of positives and negatives or 100 times more negatives than positives and then tested on both types of datasets.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "eoct") (:form . "EOCT") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "module") (:form . 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"numbers") (:end . 164)\n  (:start . 157) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 177)\n  (:start . 168) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 191)\n  (:start . 182) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 194) (:start . 192)\n  (:id . 74))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 198) (:start . 195)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 204)\n  (:start . 199) (:id . 76))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 209) (:start . 205)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 219)\n  (:start . 210) (:id . 78))\n ((:tag . "IN") (:stem . "than") (:form . 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(:end . 277) (:start . 276)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x2.182.1) (:span 144 150 192 194)))\n (:hscopes ((:id . :x2.182.1) (:span 144 234)))\n (:identifiers (:sid . :s2.182) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100510@unknown@formal@none@1@S@For example, the 1:1 pos:neg trained predictor achieves a ROC50 AUC of 0.0645 whereas its 1:100 pos:neg trained counterpart achieves a 0.0747 ROC50 AUC.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1:1") (:form . "1:1") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "pos:neg") (:form . "pos:neg") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "trained") (:form . "trained") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "0.0645") (:form . "0.0645") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1:100") (:form . "1:100") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "pos:neg") (:form . "pos:neg") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "trained") (:form . "trained") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "counterpart") (:form . "counterpart") (:end . 123)\n  (:start . 112) (:id . 61))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "CD") (:stem . "0.0747") (:form . "0.0747") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 147)\n  (:start . 142) (:id . 65))\n ((:tag . "NNP") (:stem . "AUC") (:form . "AUC") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.184) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100511@unknown@formal@none@1@S@This could be due to the fact that the number of non-interacting protein pairs outweighs greatly the number of interacting protein pairs in cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 45)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 64) (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "outweigh") (:form . "outweighs") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 122)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.185.1) (:span 5 10)))\n (:hscopes ((:id . :x2.185.1) (:span 5 145)))\n (:identifiers (:sid . :s2.185) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100512@unknown@formal@none@1@S@When equal numbers of positives and negatives are used in training, the diversity that exists in the non-interacting protein pair space may not be captured, thus resulting in misleading likelihood ratios for the predictive modules.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 93)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 116) (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "capture") (:form . "captured") (:end . 155)\n  (:start . 147) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 68))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 171)\n  (:start . 162) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "mislead") (:form . "misleading") (:end . 185)\n  (:start . 175) (:id . 72))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 196)\n  (:start . 186) (:id . 73))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 203)\n  (:start . 197) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 207) (:start . 204)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 222)\n  (:start . 212) (:id . 77))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 230)\n  (:start . 223) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x2.186.1) (:span 136 139)))\n (:ncues ((:id . :x2.186.2) (:span 140 143)))\n (:hscopes ((:id . :x2.186.1) (:span 68 155)))\n (:nscopes ((:id . :x2.186.2) (:span 68 155)))\n (:identifiers (:sid . :s2.186) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100513@unknown@formal@none@1@S@It should be noted that predictors tested on datasets consisting of equal numbers of positives and negatives achieve much higher accuracy measures than those tested on datasets containing 100 times more negatives than positives.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 41) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 64)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 146)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 157)\n  (:start . 152) (:id . 65))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 164)\n  (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 176)\n  (:start . 168) (:id . 68))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 187)\n  (:start . 177) (:id . 69))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 197)\n  (:start . 192) (:id . 71))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 202) (:start . 198)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 212)\n  (:start . 203) (:id . 73))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 217) (:start . 213)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 227)\n  (:start . 218) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.187) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100514@unknown@formal@none@1@S@This is because the number of positives scoring higher than the highest scoring n negatives, for a given value of n and a given predictor, will be greater if there are equal numbers of positives and negatives in the test set than if there are more negatives than positives.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "VBG") (:stem . "score") (:form . 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"be") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 154)\n  (:start . 147) (:id . 71))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 157) (:start . 155)\n  (:id . 72))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 163)\n  (:start . 158) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 167) (:start . 164)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 173)\n  (:start . 168) (:id . 75))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 181)\n  (:start . 174) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 194)\n  (:start . 185) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 208)\n  (:start . 199) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 82))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 220) (:start . 216)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 224) (:start . 221)\n  (:id . 84))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 229) (:start . 225)\n  (:id . 85))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 232) (:start . 230)\n  (:id . 86))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 238)\n  (:start . 233) (:id . 87))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 242) (:start . 239)\n  (:id . 88))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 247) (:start . 243)\n  (:id . 89))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 257)\n  (:start . 248) (:id . 90))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 262) (:start . 258)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 272)\n  (:start . 263) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s2.188) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100515@unknown@formal@none@1@S@Influence of the negative:positive training set ratio on the prediction accuracy@(((:tag . "NN") (:stem . "influence") (:form . "Influence") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "negative:positive") (:form . "negative:positive")\n  (:end . 34) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 80)\n  (:start . 72) (:id . 52)))@@@1@11@((:identifiers (:sid . :s2.189) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5100516@unknown@formal@none@1@S@The ROCn AUCs are an average of five separate experiments (each of which is itself a five-fold cross validation experiment).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ROCn") (:form . "ROCn") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "AUC") (:form . "AUCs") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 57)\n  (:start . 46) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 94)\n  (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "cross") (:form . "cross") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 111)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.190) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100517@unknown@formal@none@1@S@Their standard deviation is shown in parenthesis.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "deviation") (:form . "deviation") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "parenthesis") (:form . "parenthesis") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.191) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100518@unknown@formal@none@1@S@The effect of localization-derived negatives rather than randomly chosen negatives was also investigated to see if it would increase the prediction accuracy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 34) (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 65)\n  (:start . 57) (:id . 49))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 72)\n  (:start . 66) (:id . 50))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 82)\n  (:start . 73) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 86) (:start . 83)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 104)\n  (:start . 92) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 111) (:start . 108)\n  (:id . 56))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 117) (:start . 115)\n  (:id . 58))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 123)\n  (:start . 118) (:id . 59))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x2.192.1) (:span 118 123))\n  ((:id . :x2.192.2) (:span 112 114)))\n (:ncues ((:id . :x2.192.3) (:span 45 56)))\n (:hscopes ((:id . :x2.192.1) (:span 118 156))\n  ((:id . :x2.192.2) (:span 112 156)))\n (:nscopes ((:id . :x2.192.3) (:span 45 82)))\n (:identifiers (:sid . :s2.192) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100520@unknown@formal@none@1@S@However, the set of interacting pairs in the full protein pair space is small and thus the contamination rate of randomly chosen negative datasets will in fact be very low.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 31)\n  (:start . 20) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 86) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "contamination") (:form . "contamination")\n  (:end . 104) (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 109) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 128)\n  (:start . 122) (:id . 64))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 146)\n  (:start . 138) (:id . 66))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s2.194) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100521@unknown@formal@none@1@S@Contamination is probably below 1%, which is likely lower than the contamination rate of the positive dataset as discussed in 47.@(((:tag . "NN") (:stem . "contamination") (:form . "Contamination")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 51)\n  (:start . 45) (:id . 51))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 57) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "contamination") (:form . "contamination")\n  (:end . 80) (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 122)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x2.195.1) (:span 45 51)) ((:id . :x2.195.2) (:span 17 25)))\n (:hscopes ((:id . :x2.195.1) (:span 45 109))\n  ((:id . :x2.195.2) (:span 17 34)))\n (:identifiers (:sid . :s2.195) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100522@unknown@formal@none@1@S@Localization-derived negatives, on the other hand, should be free of contamination, if the localization annotations are complete and accurate, both conditions that are difficult to obtain as discussed in 54.@(((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "Localization-derived") (:end . 20) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 30)\n  (:start . 21) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 44) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "free") (:form . "free") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "contamination") (:form . "contamination")\n  (:end . 82) (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 115)\n  (:start . 104) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 128)\n  (:start . 120) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 141)\n  (:start . 133) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 177)\n  (:start . 168) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "VB") (:stem . "obtain") (:form . "obtain") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "CD") (:stem . "54") (:form . "54") (:end . 206) (:start . 204)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x2.196.1) (:span 51 57)))\n (:hscopes ((:id . :x2.196.1) (:span 51 82)))\n (:identifiers (:sid . :s2.196) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100523@unknown@formal@none@1@S@However, one can argue that localization-derived negatives might not be able to capture the full diversity of the non-interacting protein space since many proteins in the same cellular compartment do not interact.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "one") (:form . "one") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "VB") (:stem . "argue") (:form . "argue") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 48) (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "VB") (:stem . "capture") (:form . "capture") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 129) (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 149)\n  (:start . 144) (:id . 64))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 163)\n  (:start . 155) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 184)\n  (:start . 176) (:id . 70))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 196)\n  (:start . 185) (:id . 71))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 212)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x2.197.3) (:span 59 64)))\n (:ncues ((:id . :x2.197.1) (:span 200 203))\n  ((:id . :x2.197.2) (:span 65 68)))\n (:hscopes ((:id . :x2.197.3) (:span 59 143)))\n (:nscopes ((:id . :x2.197.1) (:span 200 212))\n  ((:id . :x2.197.2) (:span 65 143)))\n (:identifiers (:sid . :s2.197) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100524@unknown@formal@none@1@S@In addition, proteins specific to a cellular compartment may have different characteristics to proteins in other compartments.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 56)\n  (:start . 45) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 91) (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 125)\n  (:start . 113) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x2.198.1) (:span 57 60)))\n (:hscopes ((:id . :x2.198.1) (:span 57 125)))\n (:identifiers (:sid . :s2.198) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100525@unknown@formal@none@1@S@Such predictors may not generalize well when predicting on cell-wide protein pairs which consist not only of non-colocalized non-interacting pairs but also numerous protein pairs that do not interact but are present in the same cellular compartment.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "generalize") (:form . "generalize") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "predict") (:form . "predicting") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "cell-wide") (:form . "cell-wide") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "consist") (:form . "consist") (:end . 96)\n  (:start . 89) (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "non-colocalized") (:form . "non-colocalized")\n  (:end . 124) (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 140) (:start . 125) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 146)\n  (:start . 141) (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 150) (:start . 147)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 164)\n  (:start . 156) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 172)\n  (:start . 165) (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 178)\n  (:start . 173) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 183) (:start . 179)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 186) (:start . 184)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 190) (:start . 187)\n  (:id . 69))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 199)\n  (:start . 191) (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 203) (:start . 200)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 207) (:start . 204)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 215)\n  (:start . 208) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 227) (:start . 223)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 236)\n  (:start . 228) (:id . 77))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 248)\n  (:start . 237) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x2.199.3) (:span 16 19)))\n (:ncues ((:id . :x2.199.1) (:span 187 190))\n  ((:id . :x2.199.2) (:span 20 23)))\n (:hscopes ((:id . :x2.199.3) (:span 16 39)))\n (:nscopes ((:id . :x2.199.1) (:span 187 199))\n  ((:id . :x2.199.2) (:span 20 39)))\n (:identifiers (:sid . :s2.199) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100526@unknown@formal@none@1@S@These issues have been discussed previously 52.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "issue") (:form . "issues") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.200) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100527@unknown@formal@none@1@S@In order to see if different types of negatives could influence the accuracy of the predictors developed here we generated negative training/test sets as in 46 by identifying all pairs of human proteins for which one protein is annotated as being nuclear and the other is annotated as being localized to the plasma membrane in the HPRD database 15.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "influence") (:form . "influence") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 94)\n  (:start . 84) (:id . 57))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 104)\n  (:start . 95) (:id . 58))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "training/test") (:form . "training/test")\n  (:end . 145) (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 174)\n  (:start . 163) (:id . 69))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 184)\n  (:start . 179) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 193)\n  (:start . 188) (:id . 73))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 202)\n  (:start . 194) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 206) (:start . 203)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 212)\n  (:start . 207) (:id . 76))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 216) (:start . 213)\n  (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 224)\n  (:start . 217) (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 227) (:start . 225)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 237)\n  (:start . 228) (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 240) (:start . 238)\n  (:id . 81))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 246) (:start . 241)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 254)\n  (:start . 247) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 258) (:start . 255)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 262) (:start . 259)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 268)\n  (:start . 263) (:id . 86))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 271) (:start . 269)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 281)\n  (:start . 272) (:id . 88))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 284) (:start . 282)\n  (:id . 89))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 290) (:start . 285)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 300)\n  (:start . 291) (:id . 91))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 303) (:start . 301)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 307) (:start . 304)\n  (:id . 93))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 314)\n  (:start . 308) (:id . 94))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 323)\n  (:start . 315) (:id . 95))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 326) (:start . 324)\n  (:id . 96))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 330) (:start . 327)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 335) (:start . 331)\n  (:id . 98))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 344)\n  (:start . 336) (:id . 99))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 347) (:start . 345)\n  (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 348) (:start . 347)\n  (:id . 101)))@@@1@60@((:hcues ((:id . :x2.201.1) (:span 48 53)) ((:id . :x2.201.2) (:span 16 18)))\n (:hscopes ((:id . :x2.201.1) (:span 48 109))\n  ((:id . :x2.201.2) (:span 16 109)))\n (:identifiers (:sid . :s2.201) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100528@unknown@formal@none@1@S@The Combined module for these predictors only considers domains and PTMs but not subcellular localization as this would result in using this feature both in the selection of the training set and as a feature predictive of interaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "ptm") (:form . "PTMs") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 135) (:start . 130)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 148)\n  (:start . 141) (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 170)\n  (:start . 161) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 70))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 186)\n  (:start . 178) (:id . 71))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 207)\n  (:start . 200) (:id . 76))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 218)\n  (:start . 208) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 78))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 233)\n  (:start . 222) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x2.202.1) (:span 114 119)))\n (:ncues ((:id . :x2.202.2) (:span 77 80)))\n (:hscopes ((:id . :x2.202.1) (:span 114 233)))\n (:nscopes ((:id . :x2.202.2) (:span 77 105)))\n (:identifiers (:sid . :s2.202) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100530@unknown@formal@none@1@S@This is most likely due to the fact that the localization-derived negative trained predictor cannot take full advantage of the Transitive module, since the network resulting from the predictions of the Group A modules likely does not sample the whole protein pair space well.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 65) (:start . 45) (:id . 52))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "trained") (:form . "trained") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "VB") (:stem . "take") (:form . "take") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 137)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 173)\n  (:start . 164) (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 194)\n  (:start . 183) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 207)\n  (:start . 202) (:id . 74))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 209) (:start . 208)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 217)\n  (:start . 210) (:id . 76))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 224)\n  (:start . 218) (:id . 77))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 229) (:start . 225)\n  (:id . 78))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 233) (:start . 230)\n  (:id . 79))\n ((:tag . "VB") (:stem . "sample") (:form . "sample") (:end . 240)\n  (:start . 234) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 250)\n  (:start . 245) (:id . 82))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 258)\n  (:start . 251) (:id . 83))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 263) (:start . 259)\n  (:id . 84))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 269)\n  (:start . 264) (:id . 85))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 274) (:start . 270)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x2.204.2) (:span 218 224))\n  ((:id . :x2.204.4) (:span 13 19)))\n (:ncues ((:id . :x2.204.1) (:span 230 233))\n  ((:id . :x2.204.3) (:span 93 99)))\n (:hscopes ((:id . :x2.204.2) (:span 218 274))\n  ((:id . :x2.204.4) (:span 13 144)))\n (:nscopes ((:id . :x2.204.1) (:span 230 274))\n  ((:id . :x2.204.3) (:span 93 144)))\n (:identifiers (:sid . :s2.204) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100531@unknown@formal@none@1@S@Our predictor trained with randomly generated negatives and a negative:positive ratio of 100 performs the best out of all the combinations of training sets investigated.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "train") (:form . "trained") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 55)\n  (:start . 46) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "negative:positive") (:form . "negative:positive")\n  (:end . 79) (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 85) (:start . 80)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "perform") (:form . "performs") (:end . 101)\n  (:start . 93) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 138)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "train") (:form . "training") (:end . 150)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 168)\n  (:start . 156) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.205) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100532@unknown@formal@none@1@S@It is this predictor that is further analyzed in subsequent sections.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.206) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100533@unknown@formal@none@1@S@Contribution of the modules@(((:tag . "NN") (:stem . "contribution") (:form . "Contribution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 27)\n  (:start . 20) (:id . 45)))@@@1@4@((:identifiers (:sid . :s2.207) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100534@unknown@formal@none@1@S@The relative contribution of the modules to the prediction of interaction was investigated in order to gain a better understanding of the predictive power and areas of highest usefulness of the different modules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 90)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 99) (:start . 94)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 130) (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 148)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 154)\n  (:start . 149) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 68))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 175)\n  (:start . 168) (:id . 69))\n ((:tag . "NN") (:stem . "usefulness") (:form . "usefulness") (:end . 186)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 203)\n  (:start . 194) (:id . 73))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 211)\n  (:start . 204) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s2.208) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100535@unknown@formal@none@1@S@To do this, all protein pairs were considered that achieve an estimated posterior odds ratio > 1 when the EOCT predictor was trained on the full datasets without cross-validation.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 23)\n  (:start . 16) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 29) (:start . 24)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 45)\n  (:start . 35) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "EOCT") (:form . "EOCT") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 120)\n  (:start . 111) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 144) (:start . 140)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 153)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 161)\n  (:start . 154) (:id . 70))\n ((:tag . "NN") (:stem . "cross-validation") (:form . "cross-validation")\n  (:end . 178) (:start . 162) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x2.209.1) (:span 154 161)))\n (:nscopes ((:id . :x2.209.1) (:span 154 178)))\n (:identifiers (:sid . :s2.209) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100536@unknown@formal@none@1@S@This set consists of 37606 distinct predicted interactions and is referred to as the LR400 dataset (all these interactions are listed and ranked in Additional File 3).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "37606") (:form . "37606") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 74)\n  (:start . 66) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 122)\n  (:start . 110) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "list") (:form . "listed") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "rank") (:form . "ranked") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 158)\n  (:start . 148) (:id . 67))\n ((:tag . "NNP") (:stem . "File") (:form . "File") (:end . 163) (:start . 159)\n  (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.210) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100537@unknown@formal@none@1@S@These protein pairs represent the most probable interactors with respect to the features considered, among all protein pairs examined by the predictor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "probable") (:form . "probable") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 106)\n  (:start . 101) (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 133)\n  (:start . 125) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 136) (:start . 134)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x2.211.1) (:span 39 47)))\n (:hscopes ((:id . :x2.211.1) (:span 39 59)))\n (:identifiers (:sid . :s2.211) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100538@unknown@formal@none@1@S@To investigate the individual contribution of each module, we looked at the number of interactions predicted out of all LR400 pairs as a function of the minimum likelihood ratio of each module.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 42)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "look") (:form . "looked") (:end . 68) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 98)\n  (:start . 86) (:id . 57))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 131)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 145)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 160)\n  (:start . 153) (:id . 69))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 171)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 185) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 192)\n  (:start . 186) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s2.212) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100540@unknown@formal@none@1@S@The Transitive module and to an even greater extent, the Combined module contribute positively to the prediction of a very high proportion of the LR400 protein pairs (73% and 91% of the LR400 interactions have likelihood ratios greater than 1 for the Transitive and Combined modules respectively).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . 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"pairs") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "CD") (:stem . "73") (:form . "73") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 73))\n ((:tag . "CD") (:stem . "91") (:form . "91") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 178) (:start . 177)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 77))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 191)\n  (:start . 186) (:id . 78))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 204)\n  (:start . 192) (:id . 79))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 209) (:start . 205)\n  (:id . 80))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 220)\n  (:start . 210) (:id . 81))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 227)\n  (:start . 221) (:id . 82))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 235)\n  (:start . 228) (:id . 83))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 240) (:start . 236)\n  (:id . 84))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 242) (:start . 241)\n  (:id . 85))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 246) (:start . 243)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 261)\n  (:start . 251) (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 265) (:start . 262)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "combined") (:form . "Combined") (:end . 274)\n  (:start . 266) (:id . 90))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 282)\n  (:start . 275) (:id . 91))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 295)\n  (:start . 283) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 296) (:start . 295)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 297) (:start . 296)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s2.214) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100541@unknown@formal@none@1@S@The Transitive module provides a likelihood ratio of 91 for the prediction of over 70% of the LR400 interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "CD") (:stem . "91") (:form . "91") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 74)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 112)\n  (:start . 100) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.215) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100542@unknown@formal@none@1@S@The Combined module provides positive evidence for the highest number of interactions of the LR400 dataset.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 62)\n  (:start . 55) (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 85)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 106)\n  (:start . 99) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.216) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100543@unknown@formal@none@1@S@However, the value of the likelihood ratio it contributes is below 20 for over 50% of protein pairs in the LR400 dataset (which means that for these protein pairs, the Combined module must be used in combination with other modules to achieve a total likelihood ratio above 400).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "ratio") (:form . 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"for") (:end . 142) (:start . 139)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 148)\n  (:start . 143) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 72))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 162)\n  (:start . 157) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 176)\n  (:start . 168) (:id . 76))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 183)\n  (:start . 177) (:id . 77))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 188) (:start . 184)\n  (:id . 78))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 191) (:start . 189)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 196) (:start . 192)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 81))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 211)\n  (:start . 200) (:id . 82))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 216) (:start . 212)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 222)\n  (:start . 217) (:id . 84))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 230)\n  (:start . 223) (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 233) (:start . 231)\n  (:id . 86))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 241)\n  (:start . 234) (:id . 87))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 243) (:start . 242)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 249)\n  (:start . 244) (:id . 89))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 260)\n  (:start . 250) (:id . 90))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 266)\n  (:start . 261) (:id . 91))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 272)\n  (:start . 267) (:id . 92))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 276) (:start . 273)\n  (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 277) (:start . 276)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 95)))@@@1@54@((:identifiers (:sid . :s2.217) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100544@unknown@formal@none@1@S@The Combined module does, however, achieve likelihood ratios high enough to predict over two thousand interactions of the LR400 dataset on its own, less than 15% of which are present in the training set.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "achieve") (:form . "achieve") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "CD") (:stem . "thousand") (:form . "thousand") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 114)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 170)\n  (:start . 165) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 182)\n  (:start . 175) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 77))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 198)\n  (:start . 190) (:id . 78))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 202) (:start . 199)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s2.218) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100545@unknown@formal@none@1@S@The Orthology module contributes to the prediction of only 8474 protein pairs in the LR400 dataset (23%).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "CD") (:stem . "8474") (:form . "8474") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 98)\n  (:start . 91) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.219) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100546@unknown@formal@none@1@S@However, a large majority (> 75%) of these 8474 predicted interactions achieve likelihood ratios above 200 from this module.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "CD") (:stem . "75") (:form . "75") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 32) (:start . 31)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 53))\n ((:tag . "CD") (:stem . "8474") (:form . "8474") (:end . 47) (:start . 43)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 57)\n  (:start . 48) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 70)\n  (:start . 58) (:id . 56))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 89)\n  (:start . 79) (:id . 58))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "CD") (:stem . "200") (:form . "200") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.220) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100547@unknown@formal@none@1@S@In fact, almost 40% of these LR400 interactions achieve a likelihood ratio above 400 from the Orthology module.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 48))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 28) (:start . 23)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 34) (:start . 29)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 47)\n  (:start . 35) (:id . 51))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 68)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 103)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.221) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100548@unknown@formal@none@1@S@This indicates that most interactions predicted by the Orthology module (alone or in combination with other modules) are based on the highest scoring Orthology bins (see Figure 1A) which are the most conserved yeast interactions (whose bin achieves a likelihood ratio of 237), as well as human paralogous interactions and interactions found in more than one model organism (both of which achieve a likelihood well above 400).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . 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"of") (:end . 381) (:start . 379)\n  (:id . 109))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 387)\n  (:start . 382) (:id . 110))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 395)\n  (:start . 388) (:id . 111))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 397) (:start . 396)\n  (:id . 112))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 408)\n  (:start . 398) (:id . 113))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 413) (:start . 409)\n  (:id . 114))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 419)\n  (:start . 414) (:id . 115))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 423) (:start . 420)\n  (:id . 116))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 424) (:start . 423)\n  (:id . 117))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 425) (:start . 424)\n  (:id . 118)))@@@1@77@((:hcues ((:id . :x2.222.1) (:span 5 19)))\n (:hscopes ((:id . :x2.222.1) (:span 5 424)))\n (:identifiers (:sid . :s2.222) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100550@unknown@formal@none@1@S@The Expression module provides positive evidence for a little less than half the predictions in the LR400 dataset.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 49))\n ((:tag . "RB") (:stem . "little") (:form . "little") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "PDT") (:stem . "half") (:form . "half") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 92)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.224) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100551@unknown@formal@none@1@S@However, as previously noted, the highest likelihood provided by this module is 33 and thus the Expression module cannot predict interaction on its own.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 52)\n  (:start . 42) (:id . 50))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 120)\n  (:start . 114) (:id . 62))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 140)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x2.225.1) (:span 114 120)))\n (:nscopes ((:id . :x2.225.1) (:span 114 151)))\n (:identifiers (:sid . :s2.225) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100552@unknown@formal@none@1@S@Contribution of the modules@(((:tag . "NN") (:stem . "contribution") (:form . "Contribution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 27)\n  (:start . 20) (:id . 45)))@@@1@4@((:identifiers (:sid . :s2.226) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100553@unknown@formal@none@1@S@Contribution of the modules.@(((:tag . "NN") (:stem . "contribution") (:form . "Contribution") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 28) (:start . 27)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s2.227) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100554@unknown@formal@none@1@S@To examine the contribution of the different modules, we plotted the number of interactions predicted among all LR400 interactions (all interactions predicted using the full predictor that obtain a likelihood ratio of interaction greater than 400) as a function of the minimum likelihood ratio of individual modules (in panel A) or of combinations of modules (in panel B).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "examine") (:form . "examine") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "plot") (:form . "plotted") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 91)\n  (:start . 79) (:id . 56))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 117)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 130)\n  (:start . 118) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 62))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 148)\n  (:start . 136) (:id . 64))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 164) (:start . 159)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 173) (:start . 169)\n  (:id . 68))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 183)\n  (:start . 174) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 188) (:start . 184)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "obtain") (:form . "obtain") (:end . 195)\n  (:start . 189) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 208)\n  (:start . 198) (:id . 73))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 214)\n  (:start . 209) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 229)\n  (:start . 218) (:id . 76))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 237)\n  (:start . 230) (:id . 77))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 242) (:start . 238)\n  (:id . 78))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 246) (:start . 243)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 247) (:start . 246)\n  (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 250) (:start . 248)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 252) (:start . 251)\n  (:id . 82))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 261)\n  (:start . 253) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 264) (:start . 262)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 268) (:start . 265)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 276)\n  (:start . 269) (:id . 86))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 287)\n  (:start . 277) (:id . 87))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 293)\n  (:start . 288) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 296) (:start . 294)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 307)\n  (:start . 297) (:id . 90))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 315)\n  (:start . 308) (:id . 91))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 317) (:start . 316)\n  (:id . 92))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 319) (:start . 317)\n  (:id . 93))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 325)\n  (:start . 320) (:id . 94))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 327) (:start . 326)\n  (:id . 95))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 328) (:start . 327)\n  (:id . 96))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 331) (:start . 329)\n  (:id . 97))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 334) (:start . 332)\n  (:id . 98))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 347)\n  (:start . 335) (:id . 99))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 350) (:start . 348)\n  (:id . 100))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 358)\n  (:start . 351) (:id . 101))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 360) (:start . 359)\n  (:id . 102))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 362) (:start . 360)\n  (:id . 103))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 368)\n  (:start . 363) (:id . 104))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 370) (:start . 369)\n  (:id . 105))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 371) (:start . 370)\n  (:id . 106))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 372) (:start . 371)\n  (:id . 107)))@@@1@66@((:identifiers (:sid . :s2.228) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100555@unknown@formal@none@1@S@In the case of combinations of modules (panel B), the minimum likelihood ratio is the product of the likelihood ratios of the modules considered.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 27)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "minimum") (:form . "minimum") (:end . 61)\n  (:start . 54) (:id . 55))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 72)\n  (:start . 62) (:id . 56))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 111)\n  (:start . 101) (:id . 63))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 118)\n  (:start . 112) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 133)\n  (:start . 126) (:id . 67))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 144)\n  (:start . 134) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.229) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100556@unknown@formal@none@1@S@Thus for example, the product of the expression and orthology ratios is greater than 1 for almost 20000 LR400 interactions and greater than 10 for approximately 10000 LR400 interactions (dark blue diamonds in panel B).@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "orthology") (:form . "orthology") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 97)\n  (:start . 91) (:id . 59))\n ((:tag . "CD") (:stem . "20000") (:form . "20000") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 122)\n  (:start . 110) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 160) (:start . 147) (:id . 68))\n ((:tag . "CD") (:stem . "10000") (:form . "10000") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 185)\n  (:start . 173) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "dark") (:form . "dark") (:end . 191) (:start . 187)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 196) (:start . 192)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "diamond") (:form . "diamonds") (:end . 205)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 76))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 214)\n  (:start . 209) (:id . 77))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 217) (:start . 216)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s2.230) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100557@unknown@formal@none@1@S@E: Expression module, O: Orthology module, C: Combined module, T: Transitive module.@(((:tag . "NN") (:stem . "e") (:form . "E") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 2) (:start . 1) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 13)\n  (:start . 3) (:id . 44))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "O") (:form . "O") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 24) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 34)\n  (:start . 25) (:id . 49))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 41)\n  (:start . 35) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 45) (:start . 44)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 54)\n  (:start . 46) (:id . 54))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 61)\n  (:start . 55) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 65) (:start . 64)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 76)\n  (:start . 66) (:id . 59))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 83)\n  (:start . 77) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.231) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100558@unknown@formal@none@1@S@Figure 4B summarizes the contributions of different combinations of modules.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "4b") (:form . "4B") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "summarize") (:form . "summarizes") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "contribution") (:form . "contributions")\n  (:end . 38) (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 64)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s2.232) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100560@unknown@formal@none@1@S@They alone can predict approximately 27000 of the 37606 interactions of the LR400 dataset.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "CD") (:stem . "27000") (:form . "27000") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "37606") (:form . "37606") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.234) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100561@unknown@formal@none@1@S@When they are both present, regardless of which other modules are also present, they predict over 70% of the LR400 interactions.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 114)\n  (:start . 109) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 127)\n  (:start . 115) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.235) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100562@unknown@formal@none@1@S@When either of these two modules is absent, fewer than 12500 interactions are predicted.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "CD") (:stem . "12500") (:form . "12500") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 73)\n  (:start . 61) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x2.236.1) (:span 36 42)))\n (:nscopes ((:id . :x2.236.1) (:span 5 42)))\n (:identifiers (:sid . :s2.236) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100563@unknown@formal@none@1@S@In contrast, the two remaining modules (Expression and Orthology) can predict approximately 5000 interactions together.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 91) (:start . 78) (:id . 56))\n ((:tag . "CD") (:stem . "5000") (:form . "5000") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.237) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100564@unknown@formal@none@1@S@This is interesting as many of the publicly available predicted interaction datasets mentioned in the Background section use mainly orthology transfer from model organisms to identify interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "RB") (:stem . "publicly") (:form . "publicly") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "VBN") (:stem . "mention") (:form . "mentioned") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 112)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 131)\n  (:start . 125) (:id . 60))\n ((:tag . "JJ") (:stem . "orthology") (:form . "orthology") (:end . 141)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 150)\n  (:start . 142) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 155) (:start . 151)\n  (:id . 63))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 171)\n  (:start . 162) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 66))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 183)\n  (:start . 175) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 196)\n  (:start . 184) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.238) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100565@unknown@formal@none@1@S@As the majority of the LR400 interactions are derived from the Combined and Transitive modules, it is possible that the method is identifying a large subset of interactions that are not common to previous human protein interaction datasets.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 41)\n  (:start . 29) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 141)\n  (:start . 130) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 156)\n  (:start . 150) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 172)\n  (:start . 160) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 181) (:start . 178)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 192)\n  (:start . 186) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 204)\n  (:start . 196) (:id . 76))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 210)\n  (:start . 205) (:id . 77))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 218)\n  (:start . 211) (:id . 78))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 230)\n  (:start . 219) (:id . 79))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 239)\n  (:start . 231) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x2.239.2) (:span 102 110)))\n (:ncues ((:id . :x2.239.1) (:span 182 185)))\n (:hscopes ((:id . :x2.239.2) (:span 102 239)))\n (:nscopes ((:id . :x2.239.1) (:span 182 239)))\n (:identifiers (:sid . :s2.239) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100566@unknown@formal@none@1@S@This is discussed further in the next section.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.240) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100567@unknown@formal@none@1@S@The curve representing the full predictor (consisting of the Expression, Orthology, Combined and Transitive modules) is also represented in Figure 4B (the dark green squares).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "curve") (:form . "curve") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 107)\n  (:start . 97) (:id . 58))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 136)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "NN") (:stem . "4b") (:form . "4B") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "dark") (:form . "dark") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . "NNS") (:stem . "square") (:form . "squares") (:end . 173)\n  (:start . 166) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s2.241) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100568@unknown@formal@none@1@S@By definition, it predicts all proteins in the LR400 dataset at likelihood ratios equal to or above 400 (this is how the LR400 dataset was generated).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 81)\n  (:start . 75) (:id . 55))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "CD") (:stem . "400") (:form . "400") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 126)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 134)\n  (:start . 127) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 138) (:start . 135)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 148)\n  (:start . 139) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.242) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100570@unknown@formal@none@1@S@As shown in Figure 4B, the full predictor predicts approximately 20000 interactions at a total likelihood ratio of 1600 (which is equivalent to an estimated posterior odds ratio of 4).@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "4b") (:form . "4B") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 41)\n  (:start . 32) (:id . 50))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 64) (:start . 51) (:id . 52))\n ((:tag . "CD") (:stem . "20000") (:form . "20000") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 83)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1600") (:form . "1600") (:end . 119) (:start . 115)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 140)\n  (:start . 130) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 166)\n  (:start . 157) (:id . 69))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 177)\n  (:start . 172) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 182) (:start . 181)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s2.244) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100571@unknown@formal@none@1@S@At a likelihood ratio of 4000, approximately 11000 interactions are predicted and at a likelihood ratio of 8000, approximately 6500 interactions are predicted.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 15)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "CD") (:stem . "4000") (:form . "4000") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 44) (:start . 31) (:id . 49))\n ((:tag . "CD") (:stem . "11000") (:form . "11000") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 63)\n  (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 97)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "CD") (:stem . "8000") (:form . "8000") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 126) (:start . 113) (:id . 62))\n ((:tag . "CD") (:stem . "6500") (:form . "6500") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 144)\n  (:start . 132) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.245) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100572@unknown@formal@none@1@S@We verified that the increasing estimated posterior odds ratios translated into better predictive value.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "verify") (:form . "verified") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "VBN") (:stem . "translate") (:form . "translated") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 86) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 103) (:start . 98)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.246) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100573@unknown@formal@none@1@S@Figure 5 shows the true positive rate versus false positive rate for different posterior odds ratios as measured by five-fold cross validation.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "cross") (:form . "cross") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.247) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100574@unknown@formal@none@1@S@As the posterior odds ratio increases, the false positive rate decreases and the relative proportion of true positives increases when compared to the proportion of false positives.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "decrease") (:form . "decreases") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 169)\n  (:start . 164) (:id . 68))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.248) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100575@unknown@formal@none@1@S@Accordingly, subsets of very high quality predictions may be generated by choosing a suitably high posterior odds ratio threshold.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "choose") (:form . "choosing") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "RB") (:stem . "suitably") (:form . "suitably") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 108)\n  (:start . 99) (:id . 58))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 130) (:start . 129)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x2.249.1) (:span 54 57)))\n (:hscopes ((:id . :x2.249.1) (:span 13 129)))\n (:identifiers (:sid . :s2.249) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100576@unknown@formal@none@1@S@True positive rate versus false positive rate for different estimated posterior odds ratios@(((:tag . "JJ") (:stem . "true") (:form . "True") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 91)\n  (:start . 85) (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.250) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100577@unknown@formal@none@1@S@True positive rate versus false positive rate for different estimated posterior odds ratios.@(((:tag . "JJ") (:stem . "true") (:form . "True") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 84) (:start . 80)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.251) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100578@unknown@formal@none@1@S@The true positive rate (TPR) versus false positive rate (FPR) is plotted for different values of the posterior odds ratio estimated for the dataset by five-fold cross-validation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TPR") (:form . "TPR") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 50)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "FPR") (:form . "FPR") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 64) (:start . 62)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "plot") (:form . "plotted") (:end . 72)\n  (:start . 65) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 86)\n  (:start . 77) (:id . 59))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 93)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 110)\n  (:start . 101) (:id . 63))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 121)\n  (:start . 116) (:id . 65))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 131)\n  (:start . 122) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 147)\n  (:start . 140) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 160)\n  (:start . 151) (:id . 71))\n ((:tag . "NN") (:stem . "cross-validation") (:form . "cross-validation")\n  (:end . 177) (:start . 161) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s2.252) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100580@unknown@formal@none@1@S@Thus, higher quality datasets can be generated by requiring higher posterior odds ratios.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 66) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.254) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100581@unknown@formal@none@1@S@The TPR is calculated as the number of true positives predicted divided by the total number of positives in the test set.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "tpr") (:form . "TPR") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 53)\n  (:start . 44) (:id . 51))\n ((:tag . "VBD") (:stem . "predict") (:form . "predicted") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.255) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100582@unknown@formal@none@1@S@The FPR is calculated as the number of false positives predicted divided by the total number of negatives in the test set.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fpr") (:form . "FPR") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 21)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "VBD") (:stem . "predict") (:form . "predicted") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 105)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.256) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100583@unknown@formal@none@1@S@Comparison to other interaction datasets@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 40)\n  (:start . 32) (:id . 46)))@@@1@5@((:identifiers (:sid . :s2.257) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100584@unknown@formal@none@1@S@The false positive rate (FPR) of our predictor was estimated by the method of D'Haeseleer and Church 1855 and used to compare it to other prediction datasets.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "FPR") (:form . "FPR") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 46)\n  (:start . 37) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 60)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 74)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "D'Haeseleer") (:form . "D’Haeseleer") (:end . 89)\n  (:start . 78) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Church") (:form . "Church") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "CD") (:stem . "1855") (:form . "1855") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 114) (:start . 110)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 125)\n  (:start . 118) (:id . 65))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 148)\n  (:start . 138) (:id . 69))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 157)\n  (:start . 149) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.258) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100585@unknown@formal@none@1@S@The Ramani interaction dataset that was automatically extracted from the literature 16 as well as all new interactions present in the October 2006 version of the manually curated HPRD database 15 (but none of the interactions also present in earlier versions of the HPRD which were used to train our predictor) were taken as reference datasets.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Ramani") (:form . "Ramani") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "automatically") (:form . "automatically")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 118)\n  (:start . 106) (:id . 59))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "October") (:form . "October") (:end . 141)\n  (:start . 134) (:id . 63))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 154)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "RB") (:stem . "manually") (:form . "manually") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "VBN") (:stem . "curate") (:form . "curated") (:end . 178)\n  (:start . 171) (:id . 69))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 192)\n  (:start . 184) (:id . 71))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 195) (:start . 193)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 225)\n  (:start . 213) (:id . 78))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 230) (:start . 226)\n  (:id . 79))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 238)\n  (:start . 231) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 241) (:start . 239)\n  (:id . 81))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 249)\n  (:start . 242) (:id . 82))\n ((:tag . "NNS") (:stem . "version") (:form . "versions") (:end . 258)\n  (:start . 250) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 261) (:start . 259)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 265) (:start . 262)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 270) (:start . 266)\n  (:id . 86))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 276)\n  (:start . 271) (:id . 87))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 281) (:start . 277)\n  (:id . 88))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 286) (:start . 282)\n  (:id . 89))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 289) (:start . 287)\n  (:id . 90))\n ((:tag . "VB") (:stem . "train") (:form . "train") (:end . 295)\n  (:start . 290) (:id . 91))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 299) (:start . 296)\n  (:id . 92))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 309)\n  (:start . 300) (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 310) (:start . 309)\n  (:id . 94))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 315) (:start . 311)\n  (:id . 95))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 321)\n  (:start . 316) (:id . 96))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 324) (:start . 322)\n  (:id . 97))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 334)\n  (:start . 325) (:id . 98))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 343)\n  (:start . 335) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 344) (:start . 343)\n  (:id . 100)))@@@1@59@((:ncues ((:id . :x2.259.1) (:span 201 205)))\n (:nscopes ((:id . :x2.259.1) (:span 201 343)))\n (:identifiers (:sid . :s2.259) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100586@unknown@formal@none@1@S@The D'Haeseleer and Church method compares two experimental datasets to a reference set and assumes that all intersections between the three datasets contain true positives.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "D'Haeseleer") (:form . "D’Haeseleer") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Church") (:form . "Church") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "compare") (:form . "compares") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 59)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "assume") (:form . "assumes") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "intersection") (:form . "intersections")\n  (:end . 122) (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 130)\n  (:start . 123) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 157)\n  (:start . 150) (:id . 64))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 162) (:start . 158)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 172)\n  (:start . 163) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x2.260.1) (:span 92 99)))\n (:hscopes ((:id . :x2.260.1) (:span 92 172)))\n (:identifiers (:sid . :s2.260) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100587@unknown@formal@none@1@S@It is thus possible to estimate the number of true positives predicted by an experimental dataset by comparing the number of interactions present in the different intersections of the two experimental methods and the reference dataset (for details, see 1855).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 89)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 137)\n  (:start . 125) (:id . 63))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 162)\n  (:start . 153) (:id . 67))\n ((:tag . "NNS") (:stem . "intersection") (:form . "intersections")\n  (:end . 176) (:start . 163) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 200)\n  (:start . 188) (:id . 72))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 208)\n  (:start . 201) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 75))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 226)\n  (:start . 217) (:id . 76))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 234)\n  (:start . 227) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 236) (:start . 235)\n  (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 239) (:start . 236)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 247)\n  (:start . 240) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 248) (:start . 247)\n  (:id . 81))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 252) (:start . 249)\n  (:id . 82))\n ((:tag . "CD") (:stem . "1855") (:form . "1855") (:end . 257) (:start . 253)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 258) (:start . 257)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x2.261.1) (:span 11 19)))\n (:hscopes ((:id . :x2.261.1) (:span 11 234)))\n (:identifiers (:sid . :s2.261) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100588@unknown@formal@none@1@S@Here, we compare three human interaction prediction datasets: the Rhodes probabilistic dataset 46, the Lehner orthology-derived dataset 36 and the most accurate of our predictors (the LR400 subset of the predictor considering the Expression, Orthology, Combined and Transitive modules).@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "compare") (:form . "compare") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 72)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "JJ") (:stem . "orthology-derived") (:form . "orthology-derived")\n  (:end . 127) (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 135)\n  (:start . 128) (:id . 61))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 160)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 196)\n  (:start . 190) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 75))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 213)\n  (:start . 204) (:id . 76))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 225)\n  (:start . 214) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 240)\n  (:start . 230) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 241) (:start . 240)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 251)\n  (:start . 242) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 252) (:start . 251)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 261)\n  (:start . 253) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 265) (:start . 262)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 276)\n  (:start . 266) (:id . 85))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 284)\n  (:start . 277) (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 285) (:start . 284)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 286) (:start . 285)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s2.262) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100590@unknown@formal@none@1@S@The rates estimated for the Rhodes and Lehner datasets are similar to previous estimates 18.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.264) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100591@unknown@formal@none@1@S@The estimated false positive rates for the LR400, Rhodes and core Lehner are quite similar (an average of 76% FPR for both the LR400 and core Lehner datasets and 78% for the Rhodes dataset) and well below the overall average false-positive rate of 90% estimated for most available human high-throughput experimental and prediction interaction datasets 18.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"prediction") (:end . 330)\n  (:start . 320) (:id . 100))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 342)\n  (:start . 331) (:id . 101))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 351)\n  (:start . 343) (:id . 102))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 354) (:start . 352)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 355) (:start . 354)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s2.265) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100592@unknown@formal@none@1@S@It should be noted that the Rhodes, Lehner and Ramani datasets annotate interactions as a relationship between human genes and not their protein products directly.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ramani") (:form . "Ramani") (:end . 53)\n  (:start . 47) (:id . 52))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 62)\n  (:start . 54) (:id . 53))\n ((:tag . "VBP") (:stem . "annotate") (:form . "annotate") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 84)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 102)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 144)\n  (:start . 137) (:id . 65))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 162)\n  (:start . 154) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x2.266.1) (:span 127 130)))\n (:nscopes ((:id . :x2.266.1) (:span 127 162)))\n (:identifiers (:sid . :s2.266) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100593@unknown@formal@none@1@S@However, not all proteins encoded by a single gene will necessarily interact with all protein products encoded by a second gene, even if one such protein pair does.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 122)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 145) (:start . 141)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 153)\n  (:start . 146) (:id . 69))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 158) (:start . 154)\n  (:id . 70))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s2.267) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100594@unknown@formal@none@1@S@This is why we describe interactions as a relationship between two proteins, allowing for a more precise description of the interaction.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 36)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "description") (:form . "description") (:end . 116)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 135)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.268) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100595@unknown@formal@none@1@S@To compare our predictions to these datasets, we consider that two genes interact if at least one of their respective protein products interact.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.269.1) (:span 49 57)))\n (:hscopes ((:id . :x2.269.1) (:span 49 143)))\n (:identifiers (:sid . :s2.269) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100596@unknown@formal@none@1@S@Comparison to other interaction datasets@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 40)\n  (:start . 32) (:id . 46)))@@@1@5@((:identifiers (:sid . :s2.270) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100597@unknown@formal@none@1@S@Comparison to other interaction datasets.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 41) (:start . 40)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s2.271) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100598@unknown@formal@none@1@S@The false positive rates shown in panel A were estimated for the LR400 dataset as well as the Rhodes [46] and Lehner [36] predictions using the method described in [18, 55] by comparing them two-by-two to a reference dataset.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 105) (:start . 104)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 116)\n  (:start . 110) (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 120) (:start . 118)\n  (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 121) (:start . 120)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 133)\n  (:start . 122) (:id . 69))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 139) (:start . 134)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 71))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 150)\n  (:start . 144) (:id . 72))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 160)\n  (:start . 151) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 165) (:start . 164)\n  (:id . 75))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 167) (:start . 165)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 77))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 171) (:start . 169)\n  (:id . 78))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 172) (:start . 171)\n  (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 175) (:start . 173)\n  (:id . 80))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 185)\n  (:start . 176) (:id . 81))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 190) (:start . 186)\n  (:id . 82))\n ((:tag . "CD") (:stem . "two-by-two") (:form . "two-by-two") (:end . 201)\n  (:start . 191) (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 204) (:start . 202)\n  (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 206) (:start . 205)\n  (:id . 85))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 216)\n  (:start . 207) (:id . 86))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 224)\n  (:start . 217) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s2.272) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100600@unknown@formal@none@1@S@In Figure 6B and 6C, we compare the number of distinct proteins and distinct interactions of the LR400 dataset to those of the Rhodes prediction dataset and the June 2006 version of the HPRD which was used to train our predictor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "6b") (:form . "6B") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "6c") (:form . "6C") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "compare") (:form . "compare") (:end . 31)\n  (:start . 24) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 42)\n  (:start . 36) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 54)\n  (:start . 46) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 89)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 133)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 144)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 165) (:start . 161)\n  (:id . 71))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 178)\n  (:start . 171) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 196)\n  (:start . 191) (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 200) (:start . 197)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 205) (:start . 201)\n  (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 80))\n ((:tag . "VB") (:stem . "train") (:form . "train") (:end . 214)\n  (:start . 209) (:id . 81))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 218) (:start . 215)\n  (:id . 82))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 228)\n  (:start . 219) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s2.274) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100601@unknown@formal@none@1@S@The Rhodes dataset was trained using an earlier version of the HPRD.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "train") (:form . "trained") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.275) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100602@unknown@formal@none@1@S@As can be seen in Figure 6, the intersections between the three datasets considered are low, especially when comparing the interactions.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "intersection") (:form . "intersections")\n  (:end . 45) (:start . 32) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 83)\n  (:start . 73) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 103)\n  (:start . 93) (:id . 60))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "compare") (:form . "comparing") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 135)\n  (:start . 123) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.276) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100603@unknown@formal@none@1@S@Both the Rhodes dataset and our LR400 dataset predict interactions involving many proteins that are not even present in their positive training set (the HPRD).@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 15)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 147) (:start . 144)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x2.277.1) (:span 100 103)))\n (:nscopes ((:id . :x2.277.1) (:span 100 158)))\n (:identifiers (:sid . :s2.277) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100604@unknown@formal@none@1@S@Many of the predictions in these two datasets concern protein pairs and proteins that are not present in other datasets, suggesting that they cover different regions of the human interaction space.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "concern") (:form . "concern") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 110)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "cover") (:form . "cover") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 190)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x2.278.1) (:span 121 131)))\n (:ncues ((:id . :x2.278.2) (:span 90 93)))\n (:hscopes ((:id . :x2.278.1) (:span 121 196)))\n (:nscopes ((:id . :x2.278.2) (:span 90 119)))\n (:identifiers (:sid . :s2.278) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100605@unknown@formal@none@1@S@As suggested in 18, by making more such datasets available, it will be possible to increase our coverage of the interaction space and determine the most likely human interactions.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 29) (:start . 23)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 48)\n  (:start . 40) (:id . 51))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 79)\n  (:start . 71) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 123)\n  (:start . 112) (:id . 64))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 129)\n  (:start . 124) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 66))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 159)\n  (:start . 153) (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 165)\n  (:start . 160) (:id . 71))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 178)\n  (:start . 166) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x2.279.1) (:span 153 159)) ((:id . :x2.279.2) (:span 71 79))\n  ((:id . :x2.279.3) (:span 3 12)))\n (:hscopes ((:id . :x2.279.1) (:span 153 178))\n  ((:id . :x2.279.2) (:span 71 178)) ((:id . :x2.279.3) (:span 3 178)))\n (:identifiers (:sid . :s2.279) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100606@unknown@formal@none@1@S@Another human interaction dataset has recently become available: the IntNetDB 56.@(((:tag . "DT") (:stem . "another") (:form . "Another") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "VBN") (:stem . "become") (:form . "become") (:end . 53)\n  (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IntNetDB") (:form . "IntNetDB") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "CD") (:stem . "56") (:form . "56") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.280) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100607@unknown@formal@none@1@S@It was generated by integrating seven different features (four of which involve transferring interactions or characteristics of protein pairs from model organisms to human) in a probabilistic framework.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "integrate") (:form . "integrating") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "VBG") (:stem . "transfer") (:form . "transferring") (:end . 92)\n  (:start . 80) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 124) (:start . 109) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 141)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 146) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 152)\n  (:start . 147) (:id . 63))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 162)\n  (:start . 153) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 171)\n  (:start . 166) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 191) (:start . 178) (:id . 70))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 201)\n  (:start . 192) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s2.281) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100608@unknown@formal@none@1@S@Interactions were predicted above a TP/FP ratio (number of true positives divided by the number of false positives in the test set) of 1.@(((:tag . "NNS") (:stem . "interaction") (:form . "Interactions") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TP/FP") (:form . "TP/FP") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s2.282) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100610@unknown@formal@none@1@S@We do not compare our predictions to this dataset because such a threshold of TP/FP > 1 does not correspond to a posterior odds threshold > 1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "TP/FP") (:form . "TP/FP") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "VB") (:stem . "correspond") (:form . "correspond") (:end . 107)\n  (:start . 97) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 122)\n  (:start . 113) (:id . 64))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "threshold") (:form . "threshold") (:end . 137)\n  (:start . 128) (:id . 66))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 141) (:start . 140)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x2.284.1) (:span 93 96)) ((:id . :x2.284.2) (:span 6 9)))\n (:nscopes ((:id . :x2.284.1) (:span 93 141))\n  ((:id . :x2.284.2) (:span 6 49)))\n (:identifiers (:sid . :s2.284) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100611@unknown@formal@none@1@S@Depending on the positive-to-negative ratio used in the datasets, TP/FP > 1 might correspond to an average posterior odds ratio of 1.@(((:tag . "VBG") (:stem . "depend") (:form . "Depending") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive-to-negative")\n  (:form . "positive-to-negative") (:end . 37) (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 43) (:start . 38)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TP/FP") (:form . "TP/FP") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "correspond") (:form . "correspond") (:end . 92)\n  (:start . 82) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x2.285.1) (:span 76 81)))\n (:hscopes ((:id . :x2.285.1) (:span 76 132)))\n (:identifiers (:sid . :s2.285) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100612@unknown@formal@none@1@S@In contrast, the average posterior odds ratio of our LR400 dataset is above 700.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "CD") (:stem . "700") (:form . "700") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.286) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100613@unknown@formal@none@1@S@In comparison, by using a threshold of TP/FP > 1 in our test set, we predict over 1 000 000 human interactions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TP/FP") (:form . "TP/FP") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "SYM") (:stem . ">") (:form . ">") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 55) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 60) (:start . 56)\n  (:id . 55))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 64) (:start . 61)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 68) (:start . 66)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 76)\n  (:start . 69) (:id . 59))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 81) (:start . 77)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 83) (:start . 82)\n  (:id . 61))\n ((:tag . "CD") (:stem . "000") (:form . "000") (:end . 87) (:start . 84)\n  (:id . 62))\n ((:tag . "CD") (:stem . "000") (:form . "000") (:end . 91) (:start . 88)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 97) (:start . 92)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 110)\n  (:start . 98) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.287.1) (:span 69 76)))\n (:hscopes ((:id . :x2.287.1) (:span 69 110)))\n (:identifiers (:sid . :s2.287) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100614@unknown@formal@none@1@S@We do not believe that the quality of this large number of predictions is high enough to warrant their publication since the great majority of these protein pairs achieve a posterior odds ratio below 1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "VB") (:stem . "believe") (:form . "believe") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 85)\n  (:start . 79) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "VB") (:stem . "warrant") (:form . "warrant") (:end . 96)\n  (:start . 89) (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 102)\n  (:start . 97) (:id . 60))\n ((:tag . "NN") (:stem . "publication") (:form . "publication") (:end . 114)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 139)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 148)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 170)\n  (:start . 163) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 182)\n  (:start . 173) (:id . 72))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 193)\n  (:start . 188) (:id . 74))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 199)\n  (:start . 194) (:id . 75))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 201) (:start . 200)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x2.288.1) (:span 10 17)))\n (:ncues ((:id . :x2.288.2) (:span 6 9)))\n (:hscopes ((:id . :x2.288.1) (:span 10 114)))\n (:nscopes ((:id . :x2.288.2) (:span 6 114)))\n (:identifiers (:sid . :s2.288) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100615@unknown@formal@none@1@S@Independent validation@(((:tag . "JJ") (:stem . "independent") (:form . "Independent") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 22)\n  (:start . 12) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.289) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100616@unknown@formal@none@1@S@Although the overlap between the LR400 dataset and the HPRD-derived positive training set is below 10% as shown in Figure 6C, the proportion of interactions common to these two sets is not equally distributed for all posterior odds ratios of interaction values.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "hprd-derived") (:form . "HPRD-derived") (:end . 67)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "6c") (:form . "6C") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 156)\n  (:start . 144) (:id . 68))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 163)\n  (:start . 157) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 181) (:start . 177)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 188) (:start . 185)\n  (:id . 75))\n ((:tag . "RB") (:stem . "equally") (:form . "equally") (:end . 196)\n  (:start . 189) (:id . 76))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 208)\n  (:start . 197) (:id . 77))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 212) (:start . 209)\n  (:id . 78))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 216) (:start . 213)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 226)\n  (:start . 217) (:id . 80))\n ((:tag . "VBZ") (:stem . "odd") (:form . "odds") (:end . 231) (:start . 227)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 238)\n  (:start . 232) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 83))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 253)\n  (:start . 242) (:id . 84))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 260)\n  (:start . 254) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x2.290.1) (:span 185 188)))\n (:nscopes ((:id . :x2.290.1) (:span 185 260)))\n (:identifiers (:sid . :s2.290) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100617@unknown@formal@none@1@S@As shown in Figure 7, while less than 3% of the protein pairs predicted to interact at posterior odds ratios between 1 and 2 overlap with the HPRD dataset used for training, this value increases to over 50% for the highest scoring subsets of the LR400 dataset.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 27) (:start . 22)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 37) (:start . 33)\n  (:id . 50))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 40) (:start . 39)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 55))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 71)\n  (:start . 62) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 83)\n  (:start . 75) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 96)\n  (:start . 87) (:id . 61))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 101) (:start . 97)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 108)\n  (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 116)\n  (:start . 109) (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 118) (:start . 117)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 66))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 124) (:start . 123)\n  (:id . 67))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 132)\n  (:start . 125) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 146) (:start . 142)\n  (:id . 71))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 154)\n  (:start . 147) (:id . 72))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 159) (:start . 155)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 74))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 172)\n  (:start . 164) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 178) (:start . 174)\n  (:id . 77))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 184)\n  (:start . 179) (:id . 78))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 194)\n  (:start . 185) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 80))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 202) (:start . 198)\n  (:id . 81))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 205) (:start . 203)\n  (:id . 82))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 206) (:start . 205)\n  (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 210) (:start . 207)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 85))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 222)\n  (:start . 215) (:id . 86))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 230)\n  (:start . 223) (:id . 87))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 238)\n  (:start . 231) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 90))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 251)\n  (:start . 246) (:id . 91))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 259)\n  (:start . 252) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s2.291) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100618@unknown@formal@none@1@S@These highest scoring predictions receive high likelihood ratios of interaction from all four predictive modules and represent the strongest examples of interaction as evaluated by our predictor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 13) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "receive") (:form . "receive") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 64)\n  (:start . 58) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 79)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 93) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 112)\n  (:start . 105) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 126)\n  (:start . 117) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "strong") (:form . "strongest") (:end . 140)\n  (:start . 131) (:id . 60))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 149)\n  (:start . 141) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 164)\n  (:start . 153) (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 167) (:start . 165)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "evaluate") (:form . "evaluated") (:end . 177)\n  (:start . 168) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 184) (:start . 181)\n  (:id . 67))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 194)\n  (:start . 185) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.292) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100620@unknown@formal@none@1@S@The highest scoring predictions in the LR400 dataset thus mainly represent interactions present in the HPRD dataset as well as interactions between proteins that have strong sequence identity to these known interacting pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 11) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 87)\n  (:start . 75) (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 156)\n  (:start . 148) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 191)\n  (:start . 183) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 200)\n  (:start . 195) (:id . 71))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 206)\n  (:start . 201) (:id . 72))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 218)\n  (:start . 207) (:id . 73))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 224)\n  (:start . 219) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s2.294) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100621@unknown@formal@none@1@S@However, as the posterior odds ratio decreases, the overlap between the predictions and the HPRD-derived training set decreases.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hprd-derived") (:form . "HPRD-derived") (:end . 104)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.295) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100622@unknown@formal@none@1@S@Some subsets of quite high posterior odds have much smaller overlaps with the training set.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "overlap") (:form . "overlaps") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.296) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100623@unknown@formal@none@1@S@For example, interactions predicted at posterior odds ratios between 128 and 2048 have a 20 to 30% overlap with the training set as shown in Figure 7.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "CD") (:stem . "128") (:form . "128") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2048") (:form . "2048") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 106)\n  (:start . 99) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 147)\n  (:start . 141) (:id . 69))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.297) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100624@unknown@formal@none@1@S@Although many of these novel predictions have not been previously investigated in the literature, there exists experimental evidence supporting a subset of these predictions which is not present in the June 2006 version of the HPRD used to train our predictor, thus providing independent validation of our method.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . 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"is") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 194)\n  (:start . 187) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 206) (:start . 202)\n  (:id . 73))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 211) (:start . 207)\n  (:id . 74))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 219)\n  (:start . 212) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 231) (:start . 227)\n  (:id . 78))\n ((:tag . 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"of") (:form . "of") (:end . 301) (:start . 299)\n  (:id . 89))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 305) (:start . 302)\n  (:id . 90))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 312)\n  (:start . 306) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 313) (:start . 312)\n  (:id . 92)))@@@1@51@((:ncues ((:id . :x2.298.1) (:span 183 186))\n  ((:id . :x2.298.2) (:span 46 49)))\n (:nscopes ((:id . :x2.298.1) (:span 183 259))\n  ((:id . :x2.298.2) (:span 9 96)))\n (:identifiers (:sid . :s2.298) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100625@unknown@formal@none@1@S@Five such validated predictions are reported here:@(((:tag . "CD") (:stem . "five") (:form . "Five") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "validated") (:form . "validated") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 50) (:start . 49)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.299) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100626@unknown@formal@none@1@S@Overlap of different subsets of the LR400 dataset with the HPRD-derived training set@(((:tag . "NN") (:stem . "overlap") (:form . "Overlap") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hprd-derived") (:form . "HPRD-derived") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 84) (:start . 81)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.300) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100627@unknown@formal@none@1@S@Overlap of different subsets of the LR400 dataset with the HPRD-derived training set.@(((:tag . "NN") (:stem . "overlap") (:form . "Overlap") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hprd-derived") (:form . "HPRD-derived") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.301) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100628@unknown@formal@none@1@S@The number of interactions predicted and the proportion of overlap with the training set (which was derived from the HPRD) were calculated for subsets of the LR400 dataset of different posterior odds ratios.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 138)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 150)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lr400") (:form . "LR400") (:end . 163)\n  (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 171)\n  (:start . 164) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 184)\n  (:start . 175) (:id . 73))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 194)\n  (:start . 185) (:id . 74))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 199) (:start . 195)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 206)\n  (:start . 200) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s2.302) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100630@unknown@formal@none@1@S@It has been recently reported that TCPTP, the only protein tyrosine phosphatase known to localize to the nucleus, dephosphorylates STAT6 in this cellular compartment, which may in turn lead to the suppression of Interleukine-4 (IL-4) induced signaling 57.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "TCPTP") (:form . "TCPTP") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "phosphatase") (:form . "phosphatase") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "VB") (:stem . "localize") (:form . "localize") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "dephosphorylate") (:form . "dephosphorylates")\n  (:end . 130) (:start . 114) (:id . 62))\n ((:tag . "NN") (:stem . "stat6") (:form . "STAT6") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 165)\n  (:start . 154) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 189) (:start . 185)\n  (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 192) (:start . 190)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 208)\n  (:start . 197) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 77))\n ((:tag . "NN") (:stem . "interleukine-4") (:form . "Interleukine-4")\n  (:end . 226) (:start . 212) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 228) (:start . 227)\n  (:id . 79))\n ((:tag . "NN") (:stem . "il-4") (:form . "IL-4") (:end . 232) (:start . 228)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 81))\n ((:tag . "VBD") (:stem . "induce") (:form . "induced") (:end . 241)\n  (:start . 234) (:id . 82))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 251)\n  (:start . 242) (:id . 83))\n ((:tag . "CD") (:stem . "57") (:form . "57") (:end . 254) (:start . 252)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 255) (:start . 254)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x2.304.1) (:span 173 176)))\n (:hscopes ((:id . :x2.304.1) (:span 173 251)))\n (:identifiers (:sid . :s2.304) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100631@unknown@formal@none@1@S@-N-WASP and ARP3 achieve a predicted posterior odds ratio of interaction of 2700.@(((:tag . "NNP") (:stem . "-N-WASP") (:form . "-N-WASP") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ARP3") (:form . "ARP3") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2700") (:form . "2700") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.305) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100632@unknown@formal@none@1@S@A recent report suggested that the IQGAP1 protein can activate N-WASP thus changing its conformation and allowing it to bind the ARP2/3 complex, which in turn directs the generation of branched actin filaments required for the extension of a lamellipodium 58.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "iqgap1") (:form . "IQGAP1") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "n-wasp") (:form . "N-WASP") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "change") (:form . "changing") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "conformation") (:form . "conformation") (:end . 100)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 113)\n  (:start . 105) (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "arp2/3") (:form . "ARP2/3") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 143)\n  (:start . 136) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "direct") (:form . "directs") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "NN") (:stem . "generation") (:form . "generation") (:end . 181)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "branch") (:form . "branched") (:end . 193)\n  (:start . 185) (:id . 73))\n ((:tag . "NN") (:stem . "actin") (:form . "actin") (:end . 199)\n  (:start . 194) (:id . 74))\n ((:tag . "NNS") (:stem . "filament") (:form . "filaments") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 222) (:start . 219)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 78))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 236)\n  (:start . 227) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 241) (:start . 240)\n  (:id . 81))\n ((:tag . "NN") (:stem . "lamellipodium") (:form . "lamellipodium")\n  (:end . 255) (:start . 242) (:id . 82))\n ((:tag . "CD") (:stem . "58") (:form . "58") (:end . 258) (:start . 256)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x2.306.1) (:span 50 53)) ((:id . :x2.306.2) (:span 16 25)))\n (:hscopes ((:id . :x2.306.1) (:span 50 69))\n  ((:id . :x2.306.2) (:span 16 255)))\n (:identifiers (:sid . :s2.306) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100633@unknown@formal@none@1@S@-The VAMP3-VTI1A interaction was predicted with a posterior odds ratio of 1518.@(((:tag . "JJ") (:stem . "-the") (:form . "-The") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "VAMP3-VTI1A") (:form . "VAMP3-VTI1A") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 42)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1518") (:form . "1518") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s2.307) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100634@unknown@formal@none@1@S@Both these proteins are believed to be part of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family of proteins which are involved in membrane fusion events.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SNARE") (:form . "SNARE") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "JJ") (:stem . "n-ethylmaleimide-sensitive")\n  (:form . "N-ethylmaleimide-sensitive") (:end . 92) (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "attachment") (:form . "attachment") (:end . 110)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 135)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 178)\n  (:start . 170) (:id . 68))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 185)\n  (:start . 179) (:id . 69))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 192)\n  (:start . 186) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x2.308.1) (:span 24 32)))\n (:hscopes ((:id . :x2.308.1) (:span 0 192)))\n (:identifiers (:sid . :s2.308) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100635@unknown@formal@none@1@S@VTI1A is a trans-Golgi-network-localized putative t-SNARE 59 and VAMP3 is an early/recycling endosomal v-SNARE 60.@(((:tag . "NNP") (:stem . "VTI1A") (:form . "VTI1A") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "trans-golgi-network-localized")\n  (:form . "trans-Golgi-network-localized") (:end . 40) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 49)\n  (:start . 41) (:id . 46))\n ((:tag . "NNP") (:stem . "t-SNARE") (:form . "t-SNARE") (:end . 57)\n  (:start . 50) (:id . 47))\n ((:tag . "CD") (:stem . "59") (:form . "59") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "VAMP3") (:form . "VAMP3") (:end . 70) (:start . 65)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "early/recycling") (:form . "early/recycling")\n  (:end . 92) (:start . 77) (:id . 53))\n ((:tag . "JJ") (:stem . "endosomal") (:form . "endosomal") (:end . 102)\n  (:start . 93) (:id . 54))\n ((:tag . "NNP") (:stem . "v-SNARE") (:form . "v-SNARE") (:end . 110)\n  (:start . 103) (:id . 55))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 113) (:start . 111)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x2.309.1) (:span 41 49)))\n (:hscopes ((:id . :x2.309.1) (:span 41 57)))\n (:identifiers (:sid . :s2.309) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100636@unknown@formal@none@1@S@These two proteins were recently shown to interact, leading to their functional implication in the post-Golgi retrograde transport step 61.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 68)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "implication") (:form . "implication") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "post-golgi") (:form . "post-Golgi") (:end . 109)\n  (:start . 99) (:id . 58))\n ((:tag . "JJ") (:stem . "retrograde") (:form . "retrograde") (:end . 120)\n  (:start . 110) (:id . 59))\n ((:tag . "NN") (:stem . "transport") (:form . "transport") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "CD") (:stem . "61") (:form . "61") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.310) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100637@unknown@formal@none@1@S@-CDK2 and MCM4 were predicted to interact at a posterior odds ratio of 62.@(((:tag . "NNP") (:stem . "-CDK2") (:form . "-CDK2") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MCM4") (:form . "MCM4") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "CD") (:stem . "62") (:form . "62") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s2.311) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100638@unknown@formal@none@1@S@CDK2 has recently been shown to phosphorylate MCM4, a subunit of a putative replicative helicase essential for DNA replication, on two distinct residues, leading to a change in its affinity to chromatin and its enrichment in the nucleolus 62.@(((:tag . "NNP") (:stem . "CDK2") (:form . "CDK2") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "phosphorylate") (:form . "phosphorylate")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "NNP") (:stem . "MCM4") (:form . "MCM4") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subunit") (:form . "subunit") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "JJ") (:stem . "replicative") (:form . "replicative") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "helicase") (:form . "helicase") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "replication") (:form . "replication") (:end . 126)\n  (:start . 115) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 143)\n  (:start . 135) (:id . 65))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "change") (:form . "change") (:end . 173)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 189)\n  (:start . 181) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 192) (:start . 190)\n  (:id . 75))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 202)\n  (:start . 193) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 77))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 210) (:start . 207)\n  (:id . 78))\n ((:tag . "NN") (:stem . "enrichment") (:form . "enrichment") (:end . 221)\n  (:start . 211) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 81))\n ((:tag . "NN") (:stem . "nucleolus") (:form . "nucleolus") (:end . 238)\n  (:start . 229) (:id . 82))\n ((:tag . "CD") (:stem . "62") (:form . "62") (:end . 241) (:start . 239)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x2.312.1) (:span 67 75)))\n (:hscopes ((:id . :x2.312.1) (:span 67 96)))\n (:identifiers (:sid . :s2.312) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100640@unknown@formal@none@1@S@This interaction has been experimentally demonstrated by large-scale yeast-two-hybrid analysis of the Smad signaling system 63.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 40) (:start . 26) (:id . 46))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 53)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "large-scale") (:form . "large-scale") (:end . 68)\n  (:start . 57) (:id . 49))\n ((:tag . "JJ") (:stem . "yeast-two-hybrid") (:form . "yeast-two-hybrid")\n  (:end . 85) (:start . 69) (:id . 50))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 94)\n  (:start . 86) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 53))\n ((:tag . "NN") (:stem . "smad") (:form . "Smad") (:end . 106) (:start . 102)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 116)\n  (:start . 107) (:id . 55))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 123)\n  (:start . 117) (:id . 56))\n ((:tag . "CD") (:stem . "63") (:form . "63") (:end . 126) (:start . 124)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.314) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100641@unknown@formal@none@1@S@Our probabilistic predictor therefore not only reproduces and completes well-known protein complexes but also identifies novel interactions, a subset of which have been independently validated.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 37)\n  (:start . 28) (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "reproduce") (:form . "reproduces") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "complete") (:form . "completes") (:end . 71)\n  (:start . 62) (:id . 50))\n ((:tag . "JJ") (:stem . "well-known") (:form . "well-known") (:end . 82)\n  (:start . 72) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 100)\n  (:start . 91) (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 104) (:start . 101)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 109) (:start . 105)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 120)\n  (:start . 110) (:id . 56))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 126)\n  (:start . 121) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 139)\n  (:start . 127) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 60))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 149)\n  (:start . 143) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 158)\n  (:start . 153) (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 163) (:start . 159)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 168) (:start . 164)\n  (:id . 65))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 182) (:start . 169) (:id . 66))\n ((:tag . "VBN") (:stem . "validate") (:form . "validated") (:end . 192)\n  (:start . 183) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s2.315) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100642@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.316) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5100643@unknown@formal@none@1@S@The current human protein interaction map is estimated to be only 10% complete 18.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "map") (:form . "map") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 78)\n  (:start . 70) (:id . 55))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x2.317.1) (:span 45 54)))\n (:hscopes ((:id . :x2.317.1) (:span 0 78)))\n (:identifiers (:sid . :s2.317) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100644@unknown@formal@none@1@S@Here, we investigated the prediction of human protein-protein interactions in an effort to increase the coverage of the human interactome while simultaneously providing high quality predictions.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 21)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 61) (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "effort") (:form . "effort") (:end . 87)\n  (:start . 81) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 137)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 158) (:start . 144) (:id . 64))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 168)\n  (:start . 159) (:id . 65))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 173) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 181)\n  (:start . 174) (:id . 67))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 193)\n  (:start . 182) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.318) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100645@unknown@formal@none@1@S@By considering several different types of orthogonal and quite distinct features including expression, orthology, combined protein characteristics and local network topology, we predicted over 37000 human protein interactions and explored a subspace of the human interactome that has not been investigated by previous large interaction datasets.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "orthogonal") (:form . 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"large") (:end . 323)\n  (:start . 318) (:id . 88))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 335)\n  (:start . 324) (:id . 89))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 344)\n  (:start . 336) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 345) (:start . 344)\n  (:id . 91)))@@@1@50@((:ncues ((:id . :x2.319.1) (:span 284 287)))\n (:nscopes ((:id . :x2.319.1) (:span 275 344)))\n (:identifiers (:sid . :s2.319) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100646@unknown@formal@none@1@S@Our investigation led us to compare the influence of different training sets on the prediction accuracy.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "investigation") (:form . "investigation")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "influence") (:form . "influence") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.320) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100647@unknown@formal@none@1@S@The use of randomly generated negative training examples and large negative-to-positive ratios in the training set generated the most accurate predictors in the context of our model.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "negative-to-positive")\n  (:form . "negative-to-positive") (:end . 87) (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 94)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 110)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 114) (:start . 111)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "generate") (:form . "generated") (:end . 124)\n  (:start . 115) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 59))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 133) (:start . 129)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 142)\n  (:start . 134) (:id . 61))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 153)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 168)\n  (:start . 161) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 181)\n  (:start . 176) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.321) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100648@unknown@formal@none@1@S@A comparison to other large human interaction datasets revealed the average false positive rate of our dataset to be 76%, which is much lower than the overall average for most large scale, currently available, human interaction datasets (experimental and computational) estimated to be 90% 18.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . 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"be") (:end . 285) (:start . 283)\n  (:id . 90))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 288) (:start . 286)\n  (:id . 91))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 289) (:start . 288)\n  (:id . 92))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 292) (:start . 290)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 293) (:start . 292)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x2.322.1) (:span 270 279)))\n (:hscopes ((:id . :x2.322.1) (:span 270 289)))\n (:identifiers (:sid . :s2.322) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100650@unknown@formal@none@1@S@We provide all our predictions ranked according to the posterior odds ratio of interaction in Additional File 3.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 30)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "rank") (:form . "ranked") (:end . 37) (:start . 31)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 90)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "NNP") (:stem . "File") (:form . "File") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.324) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100651@unknown@formal@none@1@S@It is thus possible to restrict the dataset to the highest scoring protein pairs (and only choose for example, protein pairs that have an estimated true positive rate of interaction above 90%).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "restrict") (:form . "restrict") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "VB") (:stem . "choose") (:form . "choose") (:end . 97)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 118)\n  (:start . 111) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 147)\n  (:start . 138) (:id . 68))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 161)\n  (:start . 153) (:id . 70))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 166) (:start . 162)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 181)\n  (:start . 170) (:id . 73))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 187)\n  (:start . 182) (:id . 74))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 190) (:start . 188)\n  (:id . 75))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x2.325.1) (:span 138 147))\n  ((:id . :x2.325.2) (:span 11 19)))\n (:hscopes ((:id . :x2.325.1) (:span 138 192))\n  ((:id . :x2.325.2) (:span 11 192)))\n (:identifiers (:sid . :s2.325) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100652@unknown@formal@none@1@S@By making this human interaction prediction dataset publicly available, it is our hope that it will help to identify the most high-confidence interactions, leading to a more complete and accurate human interaction map.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "RB") (:stem . "publicly") (:form . "publicly") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hope") (:form . "hope") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "high-confidence") (:form . "high-confidence")\n  (:end . 141) (:start . 126) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 154)\n  (:start . 142) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 173) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 182)\n  (:start . 174) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 186) (:start . 183)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 201)\n  (:start . 196) (:id . 74))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 213)\n  (:start . 202) (:id . 75))\n ((:tag . "NN") (:stem . "map") (:form . "map") (:end . 217) (:start . 214)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x2.326.1) (:span 82 86)))\n (:hscopes ((:id . :x2.326.1) (:span 82 217)))\n (:identifiers (:sid . :s2.326) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100653@unknown@formal@none@1@S@Methods@(((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.327) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5100654@unknown@formal@none@1@S@Datasets@(((:tag . "NNP") (:stem . "Dataset") (:form . "Datasets") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.328) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100655@unknown@formal@none@1@S@In order to investigate the likelihood of interaction of human proteins, 62322 human protein sequences were downloaded from the International Protein Index (IPI) database (version 3.16) 64.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "CD") (:stem . "62322") (:form . "62322") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "International") (:form . "International")\n  (:end . 141) (:start . 128) (:id . 62))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 149)\n  (:start . 142) (:id . 63))\n ((:tag . "NNP") (:stem . "Index") (:form . "Index") (:end . 155)\n  (:start . 150) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 170)\n  (:start . 162) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 179)\n  (:start . 172) (:id . 70))\n ((:tag . "CD") (:stem . "3.16") (:form . "3.16") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 72))\n ((:tag . "CD") (:stem . "64") (:form . "64") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s2.329) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100656@unknown@formal@none@1@S@Some of these proteins are alternative transcripts of the same gene but can have distinct interaction partners.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 101)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.330) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100657@unknown@formal@none@1@S@Known interactions were downloaded from the Human Protein Reference Database (HPRD; June 2006 version) 15.@(((:tag . "NN") (:stem . "known") (:form . "Known") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "Reference") (:form . "Reference") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "NNP") (:stem . "Database") (:form . "Database") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.331) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100658@unknown@formal@none@1@S@Duplicate interactions and self-interactions were not considered.@(((:tag . "JJ") (:stem . "duplicate") (:form . "Duplicate") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "self-interaction") (:form . "self-interactions")\n  (:end . 44) (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 53) (:start . 50)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 64)\n  (:start . 54) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 49)))@@@1@8@((:ncues ((:id . :x2.332.1) (:span 50 53)))\n (:nscopes ((:id . :x2.332.1) (:span 0 64)))\n (:identifiers (:sid . :s2.332) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100660@unknown@formal@none@1@S@This resulted in 26896 distinct human protein interactions involving 7531 distinct human proteins present in the initial IPI dataset.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "26896") (:form . "26896") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 58)\n  (:start . 46) (:id . 49))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 68)\n  (:start . 59) (:id . 50))\n ((:tag . "CD") (:stem . "7531") (:form . "7531") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 88) (:start . 83)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 105)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 124) (:start . 121)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.334) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100661@unknown@formal@none@1@S@The 26896 interactions from the June 2006 version of the HPRD were used as the positive dataset in the training/testing of the predictor.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "26896") (:form . "26896") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "training/testing") (:form . "training/testing")\n  (:end . 119) (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.335) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100662@unknown@formal@none@1@S@Two different sets of non-interacting protein pairs were investigated: the main analysis employed a randomly-generated negative dataset but this was also compared to a localization-derived negative dataset.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "VBD") (:stem . "employ") (:form . "employed") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "randomly-generated") (:form . "randomly-generated")\n  (:end . 118) (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 127)\n  (:start . 119) (:id . 58))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 135)\n  (:start . 128) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 139) (:start . 136)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 153) (:start . 149)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 188) (:start . 168) (:id . 67))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 197)\n  (:start . 189) (:id . 68))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 205)\n  (:start . 198) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.336) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100663@unknown@formal@none@1@S@Both non-interacting protein datasets were cleaned by removing all protein pairs that came from the positive dataset as well as protein pairs that were annotated as interacting in other databases (DIP 65: 679 interactions, BIND 66: 2650 interactions), or predicted to interact in other studies (OPHID 67: 21815 interactions).@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 20) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clean") (:form . "cleaned") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "remove") (:form . "removing") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "come") (:form . "came") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 161)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "interacting") (:form . "interacting") (:end . 176)\n  (:start . 165) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 195)\n  (:start . 186) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "DIP") (:form . "DIP") (:end . 200) (:start . 197)\n  (:id . 73))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . "CD") (:stem . "679") (:form . "679") (:end . 208) (:start . 205)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 221)\n  (:start . 209) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "BIND") (:form . "BIND") (:end . 227) (:start . 223)\n  (:id . 79))\n ((:tag . "CD") (:stem . "66") (:form . "66") (:end . 230) (:start . 228)\n  (:id . 80))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 231) (:start . 230)\n  (:id . 81))\n ((:tag . "CD") (:stem . "2650") (:form . "2650") (:end . 236) (:start . 232)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 249)\n  (:start . 237) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 250) (:start . 249)\n  (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 251) (:start . 250)\n  (:id . 85))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 254) (:start . 252)\n  (:id . 86))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 264)\n  (:start . 255) (:id . 87))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 267) (:start . 265)\n  (:id . 88))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 276)\n  (:start . 268) (:id . 89))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 279) (:start . 277)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 285)\n  (:start . 280) (:id . 91))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 293)\n  (:start . 286) (:id . 92))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 295) (:start . 294)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "OPHID") (:form . "OPHID") (:end . 300)\n  (:start . 295) (:id . 94))\n ((:tag . "CD") (:stem . "67") (:form . "67") (:end . 303) (:start . 301)\n  (:id . 95))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 304) (:start . 303)\n  (:id . 96))\n ((:tag . "CD") (:stem . "21815") (:form . "21815") (:end . 310)\n  (:start . 305) (:id . 97))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 323)\n  (:start . 311) (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 324) (:start . 323)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 325) (:start . 324)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s2.337) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100664@unknown@formal@none@1@S@Of the 62322 human proteins from the initial IPI dataset, 22889 were characterized by at least one of the features that we considered to predict interaction (see the Features section).@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "62322") (:form . "62322") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "CD") (:stem . "22889") (:form . "22889") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 82) (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "consider") (:form . "considered") (:end . 133)\n  (:start . 123) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 144)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 156)\n  (:start . 145) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NNPS") (:stem . "Feature") (:form . "Features") (:end . 174)\n  (:start . 166) (:id . 72))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 182)\n  (:start . 175) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s2.338) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100665@unknown@formal@none@1@S@These 22889 human proteins are encoded by 16904 distinct genes and are referred to as the Informative Protein Set.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "22889") (:form . "22889") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "16904") (:form . "16904") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "informative") (:form . "Informative") (:end . 101)\n  (:start . 90) (:id . 58))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NNP") (:stem . "Set") (:form . "Set") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.339) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100666@unknown@formal@none@1@S@The randomly-generated negative dataset used for the training and testing of the predictor was created by selecting protein pairs at random from the Informative Protein Set.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "randomly-generated") (:form . "randomly-generated")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 39)\n  (:start . 32) (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "select") (:form . "selecting") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 129)\n  (:start . 124) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "NN") (:stem . "random") (:form . "random") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "informative") (:form . "Informative") (:end . 160)\n  (:start . 149) (:id . 65))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 168)\n  (:start . 161) (:id . 66))\n ((:tag . "NNP") (:stem . "Set") (:form . "Set") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s2.340) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100667@unknown@formal@none@1@S@In contrast, the localization-derived negative dataset was created by selecting protein pairs from the Informative Protein Set for which the HPRD 15 annotates one as being primarily in the plasma membrane and the other as primarily in the nucleus.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "localization-derived")\n  (:form . "localization-derived") (:end . 37) (:start . 17) (:id . 46))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "select") (:form . "selecting") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 93) (:start . 88)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "informative") (:form . "Informative") (:end . 114)\n  (:start . 103) (:id . 57))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 122)\n  (:start . 115) (:id . 58))\n ((:tag . "NNP") (:stem . "Set") (:form . "Set") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 136)\n  (:start . 131) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 145) (:start . 141)\n  (:id . 63))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 148) (:start . 146)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "annotate") (:form . "annotates") (:end . 158)\n  (:start . 149) (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 171) (:start . 166)\n  (:id . 68))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 71))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 195)\n  (:start . 189) (:id . 72))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 204)\n  (:start . 196) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 212) (:start . 209)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 218)\n  (:start . 213) (:id . 76))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 221) (:start . 219)\n  (:id . 77))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 231)\n  (:start . 222) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 234) (:start . 232)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 238) (:start . 235)\n  (:id . 80))\n ((:tag . "NN") (:stem . "nucleus") (:form . "nucleus") (:end . 246)\n  (:start . 239) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s2.341) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100668@unknown@formal@none@1@S@Training and testing was performed with 5-fold cross-validation.@(((:tag . "NN") (:stem . "training") (:form . "Training") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "5-fold") (:form . "5-fold") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "cross-validation") (:form . "cross-validation")\n  (:end . 63) (:start . 47) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.342) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100670@unknown@formal@none@1@S@The predictions were compared to the literature-mined Ramani dataset 16, the orthology-derived Lehner prediction dataset 36 and the probabilistic Rhodes prediction dataset 46.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "literature-mined") (:form . "literature-mined")\n  (:end . 53) (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "Ramani") (:form . "Ramani") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "orthology-derived") (:form . "orthology-derived")\n  (:end . 94) (:start . 77) (:id . 54))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 101)\n  (:start . 95) (:id . 55))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 112)\n  (:start . 102) (:id . 56))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 120)\n  (:start . 113) (:id . 57))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "probabilistic") (:form . "probabilistic")\n  (:end . 145) (:start . 132) (:id . 61))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 152)\n  (:start . 146) (:id . 62))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 163)\n  (:start . 153) (:id . 63))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 171)\n  (:start . 164) (:id . 64))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 174) (:start . 172)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.344) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100671@unknown@formal@none@1@S@All three datasets identify the interactions by stating the names and/or gene locus IDs of the genes that encode the interacting proteins.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "state") (:form . "stating") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "name") (:form . "names") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "id") (:form . "IDs") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.345) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100672@unknown@formal@none@1@S@In contrast, we work directly on the protein sequences and so related the gene annotations to our protein identifiers by extracting Entrez Gene IDs corresponding to the IPI protein entries from the IPI cross-reference files (for the IPI release 3.24) 64.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "work") (:form . "work") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "NNS") (:stem . "identifier") (:form . "identifiers") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "extract") (:form . "extracting") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "NNP") (:stem . "Entrez") (:form . "Entrez") (:end . 138)\n  (:start . 132) (:id . 64))\n ((:tag . "NNP") (:stem . "Gene") (:form . "Gene") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "IDs") (:form . "IDs") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 161)\n  (:start . 148) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 180)\n  (:start . 173) (:id . 71))\n ((:tag . "NNS") (:stem . "entry") (:form . "entries") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 193) (:start . 189)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cross-reference") (:form . "cross-reference")\n  (:end . 217) (:start . 202) (:id . 76))\n ((:tag . "NNS") (:stem . "file") (:form . "files") (:end . 223)\n  (:start . 218) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 225) (:start . 224)\n  (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 228) (:start . 225)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "IPI") (:form . "IPI") (:end . 236) (:start . 233)\n  (:id . 81))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 244)\n  (:start . 237) (:id . 82))\n ((:tag . "CD") (:stem . "3.24") (:form . "3.24") (:end . 249) (:start . 245)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 250) (:start . 249)\n  (:id . 84))\n ((:tag . "CD") (:stem . "64") (:form . "64") (:end . 253) (:start . 251)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s2.346) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100673@unknown@formal@none@1@S@Ensembl gene identifiers (Ensembl 42) were also matched to Entrez Locus IDs (NCBI36) using BioMart 68.@(((:tag . "NNP") (:stem . "Ensembl") (:form . "Ensembl") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "identifier") (:form . "identifiers") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ensembl") (:form . "Ensembl") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "CD") (:stem . "42") (:form . "42") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "match") (:form . "matched") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Entrez") (:form . "Entrez") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "NNP") (:stem . "Locus") (:form . "Locus") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ID") (:form . "IDs") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NCBI36") (:form . "NCBI36") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "BioMart") (:form . "BioMart") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "CD") (:stem . "68") (:form . "68") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.347) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100674@unknown@formal@none@1@S@Some gene-gene entries were not recovered in the conversion between different identifiers, or due to the deletion or replacement of some Entrez Locus IDs.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "gene-gene") (:form . "gene-gene") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "entry") (:form . "entries") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "identifier") (:form . "identifiers") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 128)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Entrez") (:form . "Entrez") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "NNP") (:stem . "Locus") (:form . "Locus") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "NNP") (:stem . "IDs") (:form . "IDs") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x2.348.1) (:span 28 31)))\n (:nscopes ((:id . :x2.348.1) (:span 0 153)))\n (:identifiers (:sid . :s2.348) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100675@unknown@formal@none@1@S@Despite this, 37714 gene-gene interactions were recovered from the Rhodes dataset and 6132 interactions from the Ramani dataset as well as 64306 and 10454 interactions from the Lehner full and core datasets respectively.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "37714") (:form . "37714") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "gene-gene") (:form . "gene-gene") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Rhodes") (:form . "Rhodes") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "CD") (:stem . "6132") (:form . "6132") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 103)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 108) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ramani") (:form . "Ramani") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "CD") (:stem . "64306") (:form . "64306") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "CD") (:stem . "10454") (:form . "10454") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 167)\n  (:start . 155) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Lehner") (:form . "Lehner") (:end . 183)\n  (:start . 177) (:id . 70))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 192) (:start . 189)\n  (:id . 72))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 197) (:start . 193)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 206)\n  (:start . 198) (:id . 74))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 219)\n  (:start . 207) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.349) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100676@unknown@formal@none@1@S@Learning method@(((:tag . "VBG") (:stem . "learn") (:form . "Learning") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 15) (:start . 9)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.350) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100677@unknown@formal@none@1@S@Semi-naïve Bayes classifiers were used to measure the likelihood of interaction of two proteins given the presence of the features considered.@(((:tag . "JJ") (:stem . "semi-naïve") (:form . "Semi-naïve") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Baye") (:form . "Bayes") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "classifier") (:form . "classifiers") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 79)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 114)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 130)\n  (:start . 122) (:id . 61))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 141)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.351) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100678@unknown@formal@none@1@S@This learning method was chosen because it allows the integration of highly heterogeneous data in a model that is easy to interpret and that can readily accommodate missing data.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "learn") (:form . "learning") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "integration") (:form . "integration") (:end . 65)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "JJ") (:stem . "heterogeneous") (:form . "heterogeneous")\n  (:end . 89) (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 94) (:start . 90)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "easy") (:form . "easy") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "VB") (:stem . "interpret") (:form . "interpret") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "VB") (:stem . "accommodate") (:form . "accommodate") (:end . 164)\n  (:start . 153) (:id . 68))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 172)\n  (:start . 165) (:id . 69))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 177)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.352) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100680@unknown@formal@none@1@S@The prediction of protein interaction is a binary problem which can be expressed in Bayesian formalism.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "bayesian") (:form . "Bayesian") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "NN") (:stem . "formalism") (:form . "formalism") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s2.354) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100681@unknown@formal@none@1@S@We are interested in determining the posterior odds ratio of interaction of two proteins, given the presence of the features we are considering.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "interested") (:form . "interested") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 143)\n  (:start . 132) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.355) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100682@unknown@formal@none@1@S@This posterior odds ratio can be re-written using Bayes rule: Opost = P(I|f1,..., fn)P(~I|f1,..., fn)=P(f1,..., fn|I)∗P(I)P(f1,..., fn)P(f1,..., fn|~I)∗P(~I)P(f1,..., fn)=P(f1,..., fn|I)∗P(I)P(f,..., fn|~I∗P(~I)=P(I)P(~I∗P(f1,..., fn|I)P(f1,..., fn|~I)=Oprior∗LR(1,...,fn) where I is a binary variable representing interaction, ~I represents non-interaction, f1 through fn are the features we are considering, Oprior is the prior odds ratio and LR is the likelihood ratio.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VB") (:stem . 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"features") (:end . 389)\n  (:start . 381) (:id . 108))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 392) (:start . 390)\n  (:id . 109))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 396) (:start . 393)\n  (:id . 110))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 408)\n  (:start . 397) (:id . 111))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 409) (:start . 408)\n  (:id . 112))\n ((:tag . "NNP") (:stem . "Oprior") (:form . "Oprior") (:end . 416)\n  (:start . 410) (:id . 113))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 419) (:start . 417)\n  (:id . 114))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 423) (:start . 420)\n  (:id . 115))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 429)\n  (:start . 424) (:id . 116))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 434) (:start . 430)\n  (:id . 117))\n ((:tag . "NN") (:stem . "ratio") (:form . 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5100683@unknown@formal@none@1@S@If the features considered are independent, the likelihood ratio LR can be calculated as the product of the individual likelihood ratios with respect to the features considered separately.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lr") (:form . "LR") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 118)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 149)\n  (:start . 142) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 176)\n  (:start . 166) (:id . 69))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 187)\n  (:start . 177) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.357) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100684@unknown@formal@none@1@S@If the features are not independent, all possible combinations of all states of these features must be considered, which can be computationally quite intensive.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "state") (:form . "states") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "RB") (:stem . "computationally") (:form . "computationally")\n  (:end . 143) (:start . 128) (:id . 65))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 149)\n  (:start . 144) (:id . 66))\n ((:tag . "JJ") (:stem . "intensive") (:form . "intensive") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x2.358.1) (:span 121 124)))\n (:ncues ((:id . :x2.358.2) (:span 20 23)))\n (:hscopes ((:id . :x2.358.1) (:span 121 159)))\n (:nscopes ((:id . :x2.358.2) (:span 20 35)))\n (:identifiers (:sid . :s2.358) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100685@unknown@formal@none@1@S@In the independent case, the likelihood ratio can be calculated as: LR(f1,...,fn)=[P(f1,..., fn|I)P(f1,..., fn|~I)]=∏i=1n[P(fi|I)P(fi~I)]@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 63)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "LR(f1") (:form . "LR(f1") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . ":") (:stem . "…") (:form . "…") (:end . 74) (:start . 74)\n  (:id . 57))\n ((:tag . "CD") (:stem . ",fn)=[P(f1") (:form . ",fn)=[P(f1") (:end . 87)\n  (:start . 77) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . ":") (:stem . "…") (:form . "…") (:end . 88) (:start . 88)\n  (:id . 60))\n ((:tag . "NN") (:stem . ", fn|I)P(f1") (:form . ", fn|I)P(f1") (:end . 102)\n  (:start . 91) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . ":") (:stem . "…") (:form . "…") (:end . 103) (:start . 103)\n  (:id . 63))\n ((:tag . "CD") (:stem . ", fn|~I)]=∏i=1n[P(fi|I)P(fi~I)")\n  (:form . ", fn|~I)]=∏i=1n[P(fi|I)P(fi~I)") (:end . 136) (:start . 106)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.359) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100686@unknown@formal@none@1@S@The likelihood ratios for the different features considered can be estimated by evaluating the ratio of the proportion of interacting and non-interacting proteins for which a particular state of the feature is true in the training set (i.e. by determining to which bin of the feature the protein pair belongs, for every protein pair in the positive and negative training sets).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "evaluate") (:form . "evaluating") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 133)\n  (:start . 122) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 153) (:start . 138) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 162)\n  (:start . 154) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 174) (:start . 173)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 185)\n  (:start . 175) (:id . 68))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 191)\n  (:start . 186) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 71))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 206)\n  (:start . 199) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 209) (:start . 207)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 214) (:start . 210)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 217) (:start . 215)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 76))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 230)\n  (:start . 222) (:id . 77))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 234) (:start . 231)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 236) (:start . 235)\n  (:id . 79))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 240) (:start . 236)\n  (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 243) (:start . 241)\n  (:id . 81))\n ((:tag . "VBG") (:stem . "determine") (:form . "determining") (:end . 255)\n  (:start . 244) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 258) (:start . 256)\n  (:id . 83))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 264)\n  (:start . 259) (:id . 84))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 268) (:start . 265)\n  (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 271) (:start . 269)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 275) (:start . 272)\n  (:id . 87))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 283)\n  (:start . 276) (:id . 88))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 287) (:start . 284)\n  (:id . 89))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 295)\n  (:start . 288) (:id . 90))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 300) (:start . 296)\n  (:id . 91))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 308)\n  (:start . 301) (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 309) (:start . 308)\n  (:id . 93))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 313) (:start . 310)\n  (:id . 94))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 319)\n  (:start . 314) (:id . 95))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 327)\n  (:start . 320) (:id . 96))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 332) (:start . 328)\n  (:id . 97))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 335) (:start . 333)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 339) (:start . 336)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 348)\n  (:start . 340) (:id . 100))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 352) (:start . 349)\n  (:id . 101))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 361)\n  (:start . 353) (:id . 102))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 370)\n  (:start . 362) (:id . 103))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 375) (:start . 371)\n  (:id . 104))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 376) (:start . 375)\n  (:id . 105))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 377) (:start . 376)\n  (:id . 106)))@@@1@65@((:identifiers (:sid . :s2.360) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100687@unknown@formal@none@1@S@More precisely, the training step consisted of calculating the respective proportions of positive and negative examples that fall into each bin of the feature(s) considered (i.e. that have a particular state).@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "precisely") (:form . "precisely") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "consist") (:form . "consisted") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "calculate") (:form . "calculating") (:end . 58)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "NNS") (:stem . "proportion") (:form . "proportions") (:end . 85)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "fall") (:form . "fall") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 134) (:start . 130)\n  (:id . 61))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 143) (:start . 140)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "feature(s)") (:form . "feature(s)") (:end . 161)\n  (:start . 151) (:id . 66))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 172)\n  (:start . 162) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 178) (:start . 174)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 201)\n  (:start . 191) (:id . 73))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 207)\n  (:start . 202) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 208) (:start . 207)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s2.361) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100688@unknown@formal@none@1@S@The likelihood ratio of interaction for a given state is simply the ratio of the proportion of all positives that have that state divided by the proportion of all negatives that have that same state.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 129)\n  (:start . 124) (:id . 64))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 155)\n  (:start . 145) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 162) (:start . 159)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 198)\n  (:start . 193) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s2.362) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100690@unknown@formal@none@1@S@Additionally, when no data are available for a specific feature (for a given pair of proteins), the likelihood of the feature is set to 1.0.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 110)\n  (:start . 100) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 65))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 125)\n  (:start . 118) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 128) (:start . 126)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 132) (:start . 129)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 139) (:start . 136)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x2.364.1) (:span 19 21)))\n (:nscopes ((:id . :x2.364.1) (:span 19 94)))\n (:identifiers (:sid . :s2.364) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100691@unknown@formal@none@1@S@For a detailed calculation of the likelihoods see Additional File 4.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "calculation") (:form . "calculation") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "likelihood") (:form . "likelihoods") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "VBP") (:stem . "see") (:form . "see") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "File") (:form . "File") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.365) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100692@unknown@formal@none@1@S@Prior odds ratio estimate@(((:tag . "JJ") (:stem . "prior") (:form . "Prior") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 25)\n  (:start . 17) (:id . 45)))@@@1@4@((:identifiers (:sid . :s2.366) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100693@unknown@formal@none@1@S@The prior odds ratio (Oprior) is difficult to estimate because we do not know all the true interactions, even for a small subset of proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Oprior") (:form . "Oprior") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 42)\n  (:start . 33) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 51))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 54)\n  (:start . 46) (:id . 52))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "VB") (:stem . "know") (:form . "know") (:end . 77) (:start . 73)\n  (:id . 57))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 90) (:start . 86)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 103)\n  (:start . 91) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 109) (:start . 105)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 121)\n  (:start . 116) (:id . 66))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 128)\n  (:start . 122) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 140)\n  (:start . 132) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x2.367.1) (:span 69 72)))\n (:nscopes ((:id . :x2.367.1) (:span 69 140)))\n (:identifiers (:sid . :s2.367) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100694@unknown@formal@none@1@S@The prior odds ratio of interaction for yeast was estimated by combining all protein-protein interactions (but only those related to direct physical interactions, and no entries derived by synthetic lethal-type experiments) from the BIND, DIP and GRID databases 656669.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 92) (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 62))\n ((:tag . "VB") (:stem . "direct") (:form . "direct") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 148)\n  (:start . 140) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 161)\n  (:start . 149) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "entry") (:form . "entries") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 185)\n  (:start . 178) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 198)\n  (:start . 189) (:id . 72))\n ((:tag . "JJ") (:stem . "lethal-type") (:form . "lethal-type") (:end . 210)\n  (:start . 199) (:id . 73))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 222)\n  (:start . 211) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 228) (:start . 224)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "BIND") (:form . "BIND") (:end . 237) (:start . 233)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "DIP") (:form . "DIP") (:end . 242) (:start . 239)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 246) (:start . 243)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "GRID") (:form . "GRID") (:end . 251) (:start . 247)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 261)\n  (:start . 252) (:id . 83))\n ((:tag . "CD") (:stem . "656669") (:form . "656669") (:end . 268)\n  (:start . 262) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x2.368.1) (:span 167 169)))\n (:nscopes ((:id . :x2.368.1) (:span 167 261)))\n (:identifiers (:sid . :s2.368) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100695@unknown@formal@none@1@S@This subset of interactions contains 36466 distinct interactions involving 5202 distinct proteins, thus resulting in a prior odds ratio of 1/370.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "CD") (:stem . "36466") (:form . "36466") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 64)\n  (:start . 52) (:id . 49))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "CD") (:stem . "5202") (:form . "5202") (:end . 79) (:start . 75)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 97)\n  (:start . 89) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 113)\n  (:start . 104) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 129) (:start . 125)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 135)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1/370") (:form . "1/370") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s2.369) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100696@unknown@formal@none@1@S@This is most likely a conservative estimate since a certain proportion of interactions remain unknown and so when more data become available, the prior odds ratio will increase.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "conservative") (:form . "conservative") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 86)\n  (:start . 74) (:id . 54))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 123)\n  (:start . 119) (:id . 61))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 176)\n  (:start . 168) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x2.370.1) (:span 94 101)) ((:id . :x2.370.2) (:span 13 19)))\n (:hscopes ((:id . :x2.370.1) (:span 50 101))\n  ((:id . :x2.370.2) (:span 13 43)))\n (:identifiers (:sid . :s2.370) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100697@unknown@formal@none@1@S@For human proteins, 12191 distinct interactions were recovered, involving 5164 human proteins from the September 2005 version of the HPRD 15 and 26896 distinct interactions involving 7531 human proteins from the June 2006 version, leading respectively to prior odds estimates of 1/1093 and 1/1053.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "12191") (:form . "12191") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 47)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "CD") (:stem . "5164") (:form . "5164") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "September") (:form . "September") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "CD") (:stem . "2005") (:form . "2005") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "CD") (:stem . "26896") (:form . "26896") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 159)\n  (:start . 151) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 172)\n  (:start . 160) (:id . 68))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 182)\n  (:start . 173) (:id . 69))\n ((:tag . "CD") (:stem . "7531") (:form . "7531") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 202)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 207) (:start . 203)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 216) (:start . 212)\n  (:id . 75))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 221) (:start . 217)\n  (:id . 76))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 229)\n  (:start . 222) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 78))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 238)\n  (:start . 231) (:id . 79))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 251)\n  (:start . 239) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 254) (:start . 252)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 260)\n  (:start . 255) (:id . 82))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 265) (:start . 261)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "estimate") (:form . "estimates") (:end . 275)\n  (:start . 266) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 278) (:start . 276)\n  (:id . 85))\n ((:tag . "CD") (:stem . "1/1093") (:form . "1/1093") (:end . 285)\n  (:start . 279) (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 289) (:start . 286)\n  (:id . 87))\n ((:tag . "CD") (:stem . "1/1053") (:form . "1/1053") (:end . 296)\n  (:start . 290) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 297) (:start . 296)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s2.371) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100698@unknown@formal@none@1@S@However, taking the subset of 5164 proteins from the September 2005 version that are seen in the June 2006 version (20842 distinct interactions), gave a prior odds of interaction estimate of 1/639.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "CD") (:stem . "5164") (:form . "5164") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "September") (:form . "September") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "CD") (:stem . "2005") (:form . "2005") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "June") (:form . "June") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "CD") (:stem . "2006") (:form . "2006") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CD") (:stem . "20842") (:form . "20842") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 143)\n  (:start . 131) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "give") (:form . "gave") (:end . 150) (:start . 146)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 158)\n  (:start . 153) (:id . 71))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 163) (:start . 159)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 73))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 178)\n  (:start . 167) (:id . 74))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 187)\n  (:start . 179) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 190) (:start . 188)\n  (:id . 76))\n ((:tag . "CD") (:stem . "1/639") (:form . "1/639") (:end . 196)\n  (:start . 191) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s2.372) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100700@unknown@formal@none@1@S@Accordingly, it is reasonable to conclude that there are not enough known human interactions to calculate a realistic and stable estimate of the prior odds ratio of interactions for human.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "reasonable") (:form . "reasonable") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VB") (:stem . "conclude") (:form . "conclude") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 92)\n  (:start . 80) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VB") (:stem . "calculate") (:form . "calculate") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "realistic") (:form . "realistic") (:end . 117)\n  (:start . 108) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 155) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 177)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 187)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x2.374.1) (:span 57 60)))\n (:nscopes ((:id . :x2.374.1) (:span 57 187)))\n (:identifiers (:sid . :s2.374) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100701@unknown@formal@none@1@S@As a consequence, a prior odds ratio of 1/400 was used for all work in the paper, which is similar to the estimate for yeast and is likely still an underestimate of the true value.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 16)\n  (:start . 5) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1/400") (:form . "1/400") (:end . 45) (:start . 40)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 67) (:start . 63)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 58))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 80) (:start . 75)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 98)\n  (:start . 91) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 65))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 114)\n  (:start . 106) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 67))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 124)\n  (:start . 119) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 70))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 138)\n  (:start . 132) (:id . 71))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 144)\n  (:start . 139) (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 147) (:start . 145)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "underestimate") (:form . "underestimate")\n  (:end . 161) (:start . 148) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 173) (:start . 169)\n  (:id . 77))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 179)\n  (:start . 174) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x2.375.1) (:span 132 138)))\n (:hscopes ((:id . :x2.375.1) (:span 132 179)))\n (:identifiers (:sid . :s2.375) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100702@unknown@formal@none@1@S@Features@(((:tag . "NNPS") (:stem . "Feature") (:form . "Features") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s2.376) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100703@unknown@formal@none@1@S@Seven distinct features combined into five modules were investigated as summarized in Table 1 and described below.@(((:tag . "CD") (:stem . "seven") (:form . "Seven") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "summarize") (:form . "summarized") (:end . 82)\n  (:start . 72) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 91) (:start . 86)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.377) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100704@unknown@formal@none@1@S@1.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 2) (:start . 1) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.378) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100705@unknown@formal@none@1@S@Expression module@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 17)\n  (:start . 11) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.379) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100706@unknown@formal@none@1@S@Expression data were downloaded from the Gene Expression Omnibus 70.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Gene") (:form . "Gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "Omnibus") (:form . "Omnibus") (:end . 64)\n  (:start . 57) (:id . 50))\n ((:tag . "CD") (:stem . "70") (:form . "70") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s2.380) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100707@unknown@formal@none@1@S@The GDS596 dataset was used which examines gene expression profiles from 79 physiologically normal tissues obtained from various sources 71.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GDS596") (:form . "GDS596") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "examine") (:form . "examines") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "profile") (:form . "profiles") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "CD") (:stem . "79") (:form . "79") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "RB") (:stem . "physiologically") (:form . "physiologically")\n  (:end . 91) (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 106)\n  (:start . 99) (:id . 56))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 115)\n  (:start . 107) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 128)\n  (:start . 121) (:id . 59))\n ((:tag . "NNS") (:stem . "source") (:form . "sources") (:end . 136)\n  (:start . 129) (:id . 60))\n ((:tag . "CD") (:stem . "71") (:form . "71") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s2.381) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100708@unknown@formal@none@1@S@Expression data were recovered for 10642 distinct transcripts in 158 different arrays (2 arrays per tissue).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "CD") (:stem . "10642") (:form . "10642") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "transcript") (:form . "transcripts") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "CD") (:stem . "158") (:form . "158") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "array") (:form . "arrays") (:end . 85)\n  (:start . 79) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "array") (:form . "arrays") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 106)\n  (:start . 100) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.382) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100710@unknown@formal@none@1@S@2.@(((:tag . "LS") (:stem . "2") (:form . "2") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 2) (:start . 1) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.384) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100711@unknown@formal@none@1@S@Orthology module@(((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 16)\n  (:start . 10) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.385) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100712@unknown@formal@none@1@S@Orthology maps between human and yeast, worm and fly were downloaded from the InParanoid database 72.@(((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "map") (:form . "maps") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "worm") (:form . "worm") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 68)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "inparanoid") (:form . "InParanoid") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "CD") (:stem . "72") (:form . "72") (:end . 100) (:start . 98)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.386) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100713@unknown@formal@none@1@S@Interaction datasets for model organisms were downloaded from the BIND 66, DIP 65 and GRID 69 databases.@(((:tag . "NNP") (:stem . "Interaction") (:form . "Interaction") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 61) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "BIND") (:form . "BIND") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "CD") (:stem . "66") (:form . "66") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DIP") (:form . "DIP") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "CD") (:stem . "65") (:form . "65") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "grid") (:form . "GRID") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "CD") (:stem . "69") (:form . "69") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.387) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100714@unknown@formal@none@1@S@Orthology interaction data were classified into 13 bins.@(((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "classify") (:form . "classified") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 47) (:start . 43)\n  (:id . 47))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s2.388) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100715@unknown@formal@none@1@S@High, medium and low confidence bins were defined for human protein pairs that have interacting orthologs in either yeast, fly or worm (for a total of 9 bins).@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 95)\n  (:start . 84) (:id . 57))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "worm") (:form . "worm") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 68))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 152) (:start . 151)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 157) (:start . 153)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s2.389) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100716@unknown@formal@none@1@S@The high confidence bins were populated by human protein pairs that have interacting orthologs that both achieve an InParanoid score of 1 (i.e. both proteins involved in an interaction in another organism are respectively the best orthology match for the two human proteins under consideration).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "populate") (:form . "populated") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 84)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "achieve") (:form . "achieve") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "inparanoid") (:form . "InParanoid") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 137) (:start . 136)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 157)\n  (:start . 149) (:id . 67))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 166)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 184)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 195)\n  (:start . 188) (:id . 73))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 204)\n  (:start . 196) (:id . 74))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 208) (:start . 205)\n  (:id . 75))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 221)\n  (:start . 209) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 225) (:start . 222)\n  (:id . 77))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 230) (:start . 226)\n  (:id . 78))\n ((:tag . "NN") (:stem . "orthology") (:form . "orthology") (:end . 240)\n  (:start . 231) (:id . 79))\n ((:tag . "NN") (:stem . "match") (:form . "match") (:end . 246)\n  (:start . 241) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 250) (:start . 247)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 254) (:start . 251)\n  (:id . 82))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 258) (:start . 255)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 264)\n  (:start . 259) (:id . 84))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 273)\n  (:start . 265) (:id . 85))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 279)\n  (:start . 274) (:id . 86))\n ((:tag . "NN") (:stem . "consideration") (:form . "consideration")\n  (:end . 293) (:start . 280) (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 294) (:start . 293)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s2.390) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100717@unknown@formal@none@1@S@The medium confidence bins were populated by human protein pairs that have interacting orthologs but only one of the interacting orthologs has an InParanoid score of 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "populate") (:form . "populated") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 96)\n  (:start . 87) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 105) (:start . 101)\n  (:id . 57))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 128)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inparanoid") (:form . "InParanoid") (:end . 156)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 162)\n  (:start . 157) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 67))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s2.391) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100718@unknown@formal@none@1@S@The low confidence bins were filled by human protein pairs that have interacting orthologs according to InParanoid but neither achieves a score of 1 (i.e. neither is the best match for the two human proteins under consideration).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "confidence") (:form . "confidence") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "fill") (:form . "filled") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "ortholog") (:form . "orthologs") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 100)\n  (:start . 91) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "InParanoid") (:form . "InParanoid") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "VBZ") (:stem . "achieve") (:form . "achieves") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 143)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 148) (:start . 147)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 154) (:start . 150)\n  (:id . 67))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 165) (:start . 163)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 70))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "match") (:form . "match") (:end . 180)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 74))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 198)\n  (:start . 193) (:id . 76))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 207)\n  (:start . 199) (:id . 77))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 213)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "consideration") (:form . "consideration")\n  (:end . 227) (:start . 214) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x2.392.1) (:span 119 126)))\n (:nscopes ((:id . :x2.392.1) (:span 119 148)))\n (:identifiers (:sid . :s2.392) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100720@unknown@formal@none@1@S@3.@(((:tag . "LS") (:stem . "3") (:form . "3") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 2) (:start . 1) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.394) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100721@unknown@formal@none@1@S@Combined module@(((:tag . "VBN") (:stem . "combine") (:form . "Combined") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 15) (:start . 9)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.395) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100722@unknown@formal@none@1@S@This module incorporates three distinct features in a non-naïve Bayesian framework: subcellular localization, domain co-occurrence and post-translational modification co-occurrence.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "incorporate") (:form . "incorporates") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "non-naïve") (:form . "non-naïve") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "bayesian") (:form . "Bayesian") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 82)\n  (:start . 73) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 95)\n  (:start . 84) (:id . 54))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 108)\n  (:start . 96) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 116)\n  (:start . 110) (:id . 57))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 130) (:start . 117) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "post-translational") (:form . "post-translational")\n  (:end . 153) (:start . 135) (:id . 60))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 166)\n  (:start . 154) (:id . 61))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 180) (:start . 167) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.396) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100723@unknown@formal@none@1@S@Subcellular localization@(((:tag . "JJ") (:stem . "subcellular") (:form . "Subcellular") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 24)\n  (:start . 12) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.397) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100724@unknown@formal@none@1@S@PSLT (Protein Subcellular Localization Tool) subcellular localization predictions 54 were used to classify protein pairs in one of four groups:: pairs of proteins predicted to be in the same compartment, pairs of proteins predicted to be in neighboring compartments (cytosol-nucleus, endoplasmic reticulum-Golgi, Golgi-cytosol, cytosol-plasma membrane, and plasma membrane-secreted), pairs of proteins predicted in different non-neighboring compartments and pairs of proteins for which there were no localization predictions.@(((:tag . "NNP") (:stem . "PSLT") (:form . "PSLT") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "Subcellular") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "NNP") (:stem . "Localization") (:form . "Localization") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "Tool") (:form . "Tool") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 81)\n  (:start . 70) (:id . 51))\n ((:tag . "CD") (:stem . "54") (:form . "54") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 89) (:start . 85)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "VB") (:stem . "classify") (:form . "classify") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 142)\n  (:start . 136) (:id . 63))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 143) (:start . 142)\n  (:id . 64))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 150)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 162)\n  (:start . 154) (:id . 68))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 172)\n  (:start . 163) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 190) (:start . 186)\n  (:id . 74))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 202)\n  (:start . 191) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 209)\n  (:start . 204) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 221)\n  (:start . 213) (:id . 79))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 231)\n  (:start . 222) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 234) (:start . 232)\n  (:id . 81))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 240) (:start . 238)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "neighboring") (:form . "neighboring") (:end . 252)\n  (:start . 241) (:id . 84))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 265)\n  (:start . 253) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 267) (:start . 266)\n  (:id . 86))\n ((:tag . "NN") (:stem . "cytosol-nucleus") (:form . "cytosol-nucleus")\n  (:end . 282) (:start . 267) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 283) (:start . 282)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "endoplasmic") (:form . "endoplasmic") (:end . 295)\n  (:start . 284) (:id . 89))\n ((:tag . "NN") (:stem . "reticulum-golgi") (:form . "reticulum-Golgi")\n  (:end . 311) (:start . 296) (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 312) (:start . 311)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "Golgi-cytosol") (:form . "Golgi-cytosol")\n  (:end . 326) (:start . 313) (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 327) (:start . 326)\n  (:id . 93))\n ((:tag . "NN") (:stem . "cytosol-plasma") (:form . "cytosol-plasma")\n  (:end . 342) (:start . 328) (:id . 94))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 351)\n  (:start . 343) (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 352) (:start . 351)\n  (:id . 96))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 356) (:start . 353)\n  (:id . 97))\n ((:tag . "NN") (:stem . "plasma") (:form . "plasma") (:end . 363)\n  (:start . 357) (:id . 98))\n ((:tag . "JJ") (:stem . "membrane-secreted") (:form . "membrane-secreted")\n  (:end . 381) (:start . 364) (:id . 99))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 382) (:start . 381)\n  (:id . 100))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 383) (:start . 382)\n  (:id . 101))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 389)\n  (:start . 384) (:id . 102))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 392) (:start . 390)\n  (:id . 103))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 401)\n  (:start . 393) (:id . 104))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 411)\n  (:start . 402) (:id . 105))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 414) (:start . 412)\n  (:id . 106))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 424)\n  (:start . 415) (:id . 107))\n ((:tag . "JJ") (:stem . "non-neighboring") (:form . "non-neighboring")\n  (:end . 440) (:start . 425) (:id . 108))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 453)\n  (:start . 441) (:id . 109))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 457) (:start . 454)\n  (:id . 110))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 463)\n  (:start . 458) (:id . 111))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 466) (:start . 464)\n  (:id . 112))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 475)\n  (:start . 467) (:id . 113))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 479) (:start . 476)\n  (:id . 114))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 485)\n  (:start . 480) (:id . 115))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 491)\n  (:start . 486) (:id . 116))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 496) (:start . 492)\n  (:id . 117))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 499) (:start . 497)\n  (:id . 118))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 512)\n  (:start . 500) (:id . 119))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 524)\n  (:start . 513) (:id . 120))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 525) (:start . 524)\n  (:id . 121)))@@@1@80@((:ncues ((:id . :x2.398.1) (:span 497 499)))\n (:nscopes ((:id . :x2.398.1) (:span 497 524)))\n (:identifiers (:sid . :s2.398) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100725@unknown@formal@none@1@S@Neighboring compartments were chosen as compartment pairs sharing a high proportion of proteins, as investigated previously 54.@(((:tag . "VBG") (:stem . "neighbor") (:form . "Neighboring") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 24)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 51)\n  (:start . 40) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "share") (:form . "sharing") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 112)\n  (:start . 100) (:id . 57))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "CD") (:stem . "54") (:form . "54") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s2.399) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100726@unknown@formal@none@1@S@Co-occurrence of domains@(((:tag . "NN") (:stem . "co-occurrence") (:form . "Co-occurrence")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 24)\n  (:start . 17) (:id . 44)))@@@1@3@((:identifiers (:sid . :s2.400) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100727@unknown@formal@none@1@S@The chi-square test was used as a measure of the likelihood of co-occurrence of specific InterPro domains and motifs 73 in protein pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "chi-square") (:form . "chi-square") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 76) (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NNP") (:stem . "InterPro") (:form . "InterPro") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "CD") (:stem . "73") (:form . "73") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 130)\n  (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.401) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100728@unknown@formal@none@1@S@Chi-square scores were calculated for all pairs of domains/motifs that occurred in the training data and were then grouped into 5 bins of increasing value.@(((:tag . "JJ") (:stem . "chi-square") (:form . "Chi-square") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "domains/motif") (:form . "domains/motifs")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "occur") (:form . "occurred") (:end . 79)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 114) (:start . 110)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 129) (:start . 128)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 148)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s2.402) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100730@unknown@formal@none@1@S@When protein pairs contained more than one domain pair, the domain pair assigned to the highest Chi-square score bin was used to assign a likelihood of interaction.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "assign") (:form . "assigned") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "chi-square") (:form . "Chi-square") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "bin") (:form . "bin") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VB") (:stem . "assign") (:form . "assign") (:end . 135)\n  (:start . 129) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 163)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s2.404) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100731@unknown@formal@none@1@S@Post-translational modification (PTM) pair co-occurrence@(((:tag . "JJ") (:stem . "post-translational") (:form . "Post-translational")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 31)\n  (:start . 19) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 36) (:start . 33)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 56) (:start . 43) (:id . 48)))@@@1@7@((:identifiers (:sid . :s2.405) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100732@unknown@formal@none@1@S@Likelihoods were assessed using a PTM pair enrichment score calculated as the probability of co-occurrence of two specific PTMs in all pairs of interacting protein pairs divided by the probability of occurrence of both of these PTMs separately: PTM_score=P(PTM[i],PTM[j]|I)P(PTM[i]|I)∗P(PTM[j]|I) where PTM[i] and PTM[j] are distinct PTMs and I is the set of all interacting proteins that were used to train the predictor.@(((:tag . "NNP") (:stem . "Likelihood") (:form . "Likelihoods") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enrichment") (:form . "enrichment") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 106) (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "NNS") (:stem . "ptm") (:form . "PTMs") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 155)\n  (:start . 144) (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 196)\n  (:start . 185) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 210)\n  (:start . 200) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 218) (:start . 214)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 76))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 227)\n  (:start . 222) (:id . 77))\n ((:tag . "NNS") (:stem . "ptm") (:form . "PTMs") (:end . 232) (:start . 228)\n  (:id . 78))\n ((:tag . "RB") (:stem . "separately") (:form . "separately") (:end . 243)\n  (:start . 233) (:id . 79))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 244) (:start . 243)\n  (:id . 80))\n ((:tag . "RB")\n  (:stem . "PTM_score=P(PTM[i],PTM[j]|I)P(PTM[i]|I)∗P(PTM[j]|I)")\n  (:form . "PTM_score=P(PTM[i],PTM[j]|I)P(PTM[i]|I)∗P(PTM[j]|I)") (:end . 296)\n  (:start . 245) (:id . 81))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 302)\n  (:start . 297) (:id . 82))\n ((:tag . "NNP") (:stem . "PTM[i") (:form . "PTM[i") (:end . 308)\n  (:start . 303) (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 309) (:start . 308)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 313) (:start . 310)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "PTM[j") (:form . "PTM[j") (:end . 319)\n  (:start . 314) (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 320) (:start . 319)\n  (:id . 87))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 324) (:start . 321)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 333)\n  (:start . 325) (:id . 89))\n ((:tag . "NNS") (:stem . "ptm") (:form . "PTMs") (:end . 338) (:start . 334)\n  (:id . 90))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 342) (:start . 339)\n  (:id . 91))\n ((:tag . "PRP") (:stem . "i") (:form . "I") (:end . 344) (:start . 343)\n  (:id . 92))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 347) (:start . 345)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 351) (:start . 348)\n  (:id . 94))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 355) (:start . 352)\n  (:id . 95))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 358) (:start . 356)\n  (:id . 96))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 362) (:start . 359)\n  (:id . 97))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 374)\n  (:start . 363) (:id . 98))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 383)\n  (:start . 375) (:id . 99))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 388) (:start . 384)\n  (:id . 100))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 393) (:start . 389)\n  (:id . 101))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 398) (:start . 394)\n  (:id . 102))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 401) (:start . 399)\n  (:id . 103))\n ((:tag . "VB") (:stem . "train") (:form . "train") (:end . 407)\n  (:start . 402) (:id . 104))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 411) (:start . 408)\n  (:id . 105))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 421)\n  (:start . 412) (:id . 106))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 422) (:start . 421)\n  (:id . 107)))@@@1@66@((:identifiers (:sid . :s2.406) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100733@unknown@formal@none@1@S@The annotations of PTMs in human proteins were downloaded from UniProt 76 and HPRD 15.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "ptm") (:form . "PTMs") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "UniProt") (:form . "UniProt") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "CD") (:stem . "76") (:form . "76") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.407) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100734@unknown@formal@none@1@S@PTM instances described as "predicted", "probable" or "possible" were excluded, leaving 3439 distinct proteins with PTM annotations in the training set.@(((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "probable") (:form . "probable") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 63)\n  (:start . 55) (:id . 55))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 69) (:start . 65)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "exclude") (:form . "excluded") (:end . 78)\n  (:start . 70) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "leave") (:form . "leaving") (:end . 87)\n  (:start . 80) (:id . 60))\n ((:tag . "CD") (:stem . "3439") (:form . "3439") (:end . 92) (:start . 88)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 101)\n  (:start . 93) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 110)\n  (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ptm") (:form . "PTM") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 131)\n  (:start . 120) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 68))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 147)\n  (:start . 139) (:id . 69))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.408) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100735@unknown@formal@none@1@S@The PTM pair enrichment scores were grouped into 4 bins of increasing value.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTM") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "enrichment") (:form . "enrichment") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.409) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100736@unknown@formal@none@1@S@The localization, co-occurrence of domains, and PTMs were considered simultaneously to measure their predictive power in assessing the likelihood of protein interaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PTM") (:form . "PTMs") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 68)\n  (:start . 58) (:id . 52))\n ((:tag . "RB") (:stem . "simultaneously") (:form . "simultaneously")\n  (:end . 83) (:start . 69) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 100)\n  (:start . 95) (:id . 56))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 111)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "assess") (:form . "assessing") (:end . 130)\n  (:start . 121) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 145)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 168)\n  (:start . 157) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.410) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100737@unknown@formal@none@1@S@To do this, all possible combinations of the 4 localization bins, 5 chi-square domain-co-occurrence bins and 4 PTM_score bins were investigated and are referred to as the combined module.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "do") (:form . "do") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 37)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 59)\n  (:start . 47) (:id . 52))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "chi-square") (:form . "chi-square") (:end . 78)\n  (:start . 68) (:id . 56))\n ((:tag . "NN") (:stem . "domain-co-occurrence")\n  (:form . "domain-co-occurrence") (:end . 99) (:start . 79) (:id . 57))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PTM_score") (:form . "PTM_score") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 143)\n  (:start . 131) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 160)\n  (:start . 152) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 179)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 186)\n  (:start . 180) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s2.411) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100738@unknown@formal@none@1@S@4.@(((:tag . "LS") (:stem . "4") (:form . "4") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 2) (:start . 1) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.412) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100740@unknown@formal@none@1@S@It has been suggested that unstructured regions of proteins are often involved in binding interactions, particularly in the case of transient interactions 77.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "unstructured") (:form . "unstructured") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 116)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "transient") (:form . "transient") (:end . 141)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 154)\n  (:start . 142) (:id . 64))\n ((:tag . "CD") (:stem . "77") (:form . "77") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x2.414.1) (:span 12 21)))\n (:hscopes ((:id . :x2.414.1) (:span 12 154)))\n (:identifiers (:sid . :s2.414) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100741@unknown@formal@none@1@S@Protein intrinsic disorder was predicted for all proteins considered by using the VSL2B predictor 78.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "intrinsic") (:form . "intrinsic") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "VSL2B") (:form . "VSL2B") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s2.415) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100742@unknown@formal@none@1@S@The disorder score for protein pairs was then calculated as the sum of percent disorder for each protein of the pair.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sum") (:form . "sum") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "percent") (:form . "percent") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s2.416) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100743@unknown@formal@none@1@S@Disorder scores were grouped into 6 bins of increasing value.@(((:tag . "NN") (:stem . "disorder") (:form . "Disorder") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s2.417) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100744@unknown@formal@none@1@S@The Expression, Orthology, Combined and Disorder modules are referred collectively as the Group A modules.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Orthology") (:form . "Orthology") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Combined") (:form . "Combined") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Disorder") (:form . "Disorder") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "RB") (:stem . "collectively") (:form . "collectively") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s2.418) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100745@unknown@formal@none@1@S@Likelihood ratios for each of the Group A modules are illustrated in Figure 1A (see Additional File 4 for complete likelihood ratios for every possible state of these modules and for detailed calculations of these likelihood ratios).@(((:tag . "NN") (:stem . "likelihood") (:form . "Likelihood") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "illustrate") (:form . "illustrated") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "NNP") (:stem . "File") (:form . "File") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 114)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "state") (:form . "state") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 174)\n  (:start . 167) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 178) (:start . 175)\n  (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 182) (:start . 179)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 191)\n  (:start . 183) (:id . 74))\n ((:tag . "NNS") (:stem . "calculation") (:form . "calculations") (:end . 204)\n  (:start . 192) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 76))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 213)\n  (:start . 208) (:id . 77))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 224)\n  (:start . 214) (:id . 78))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 231)\n  (:start . 225) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s2.419) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100746@unknown@formal@none@1@S@5.@(((:tag . "LS") (:stem . "5") (:form . "5") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 2) (:start . 1) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.420) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100747@unknown@formal@none@1@S@Transitive module@(((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 17)\n  (:start . 11) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.421) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100748@unknown@formal@none@1@S@The transitive module works on the premise that a pair of proteins is more likely to interact if it shares interacting partners.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "work") (:form . "works") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "premise") (:form . "premise") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 66)\n  (:start . 58) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "share") (:form . "shares") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 118)\n  (:start . 107) (:id . 62))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x2.422.1) (:span 75 81)))\n (:hscopes ((:id . :x2.422.1) (:span 48 127)))\n (:identifiers (:sid . :s2.422) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100750@unknown@formal@none@1@S@Thus, the transitive module takes as input the product of the likelihood ratios of all other modules considered by the predictor (as illustrated in Figure 1B).@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "input") (:form . "input") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 72)\n  (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 128)\n  (:start . 119) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "illustrate") (:form . "illustrated") (:end . 144)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 154)\n  (:start . 148) (:id . 68))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 157) (:start . 155)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s2.424) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100751@unknown@formal@none@1@S@For each pair of proteins in the training set, the product of the likelihood ratios from all other modules (referred to as the preliminary score (PS) in Figure 1) was calculated for all protein pairs neighboring the pair (i.e. all protein pairs which involve one protein from the initial protein pair under study and for which it is possible to calculate such a score).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 76)\n  (:start . 66) (:id . 56))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 106)\n  (:start . 99) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 116)\n  (:start . 108) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 138)\n  (:start . 127) (:id . 67))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PS") (:form . "PS") (:end . 148) (:start . 146)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 152) (:start . 150)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 159)\n  (:start . 153) (:id . 73))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 161) (:start . 160)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 166) (:start . 163)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 177)\n  (:start . 167) (:id . 77))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 78))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 185) (:start . 182)\n  (:id . 79))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 193)\n  (:start . 186) (:id . 80))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 199)\n  (:start . 194) (:id . 81))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 211)\n  (:start . 200) (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 83))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 220) (:start . 216)\n  (:id . 84))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 222) (:start . 221)\n  (:id . 85))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 226) (:start . 222)\n  (:id . 86))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 230) (:start . 227)\n  (:id . 87))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 238)\n  (:start . 231) (:id . 88))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 244)\n  (:start . 239) (:id . 89))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 250)\n  (:start . 245) (:id . 90))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 258)\n  (:start . 251) (:id . 91))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 262) (:start . 259)\n  (:id . 92))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 270)\n  (:start . 263) (:id . 93))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 275) (:start . 271)\n  (:id . 94))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 279) (:start . 276)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 287)\n  (:start . 280) (:id . 96))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 295)\n  (:start . 288) (:id . 97))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 300) (:start . 296)\n  (:id . 98))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 306)\n  (:start . 301) (:id . 99))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 312)\n  (:start . 307) (:id . 100))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 316) (:start . 313)\n  (:id . 101))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 320) (:start . 317)\n  (:id . 102))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 326)\n  (:start . 321) (:id . 103))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 329) (:start . 327)\n  (:id . 104))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 332) (:start . 330)\n  (:id . 105))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 341)\n  (:start . 333) (:id . 106))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 344) (:start . 342)\n  (:id . 107))\n ((:tag . "VB") (:stem . "calculate") (:form . "calculate") (:end . 354)\n  (:start . 345) (:id . 108))\n ((:tag . "PDT") (:stem . "such") (:form . "such") (:end . 359) (:start . 355)\n  (:id . 109))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 361) (:start . 360)\n  (:id . 110))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 367)\n  (:start . 362) (:id . 111))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 368) (:start . 367)\n  (:id . 112))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 369) (:start . 368)\n  (:id . 113)))@@@1@72@((:hcues ((:id . :x2.425.1) (:span 333 341)))\n (:hscopes ((:id . :x2.425.1) (:span 333 367)))\n (:identifiers (:sid . :s2.425) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100752@unknown@formal@none@1@S@All preliminary scores above 10 were kept.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "keep") (:form . "kept") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s2.426) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100753@unknown@formal@none@1@S@This parameter was determined empirically.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "empirically") (:form . "empirically") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 47)))@@@1@6@((:identifiers (:sid . :s2.427) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100754@unknown@formal@none@1@S@A neighborhood topology score T was then calculated as follows:@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "neighborhood") (:form . "neighborhood") (:end . 14)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 31) (:start . 30)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 63) (:start . 62)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s2.428) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100755@unknown@formal@none@1@S@Transitive module hypothesis@(((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 28)\n  (:start . 18) (:id . 44)))@@@1@3@((:identifiers (:sid . :s2.429) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100756@unknown@formal@none@1@S@Transitive module hypothesis.@(((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 28)\n  (:start . 18) (:id . 44))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 29) (:start . 28)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s2.430) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100757@unknown@formal@none@1@S@The Transitive module investigates whether two proteins (such as i and j) that share many common interactors and have few additional interactors that are not common to both proteins are more likely to interact than two proteins (such as i' and j') that share few common interactors.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transitive") (:form . "Transitive") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "investigate") (:form . "investigates") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 55)\n  (:start . 47) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "i") (:form . "i") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "j") (:form . "j") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 144)\n  (:start . 133) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 164)\n  (:start . 158) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 172) (:start . 168)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 190) (:start . 186)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 197)\n  (:start . 191) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 76))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 209)\n  (:start . 201) (:id . 77))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 214) (:start . 210)\n  (:id . 78))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 218) (:start . 215)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 227)\n  (:start . 219) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 233) (:start . 229)\n  (:id . 82))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 236) (:start . 234)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "i") (:form . "i") (:end . 238) (:start . 237)\n  (:id . 84))\n ((:tag . "POS") (:stem . "'") (:form . "’") (:end . 239) (:start . 238)\n  (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "j") (:form . "j") (:end . 245) (:start . 244)\n  (:id . 87))\n ((:tag . "''") (:stem . "'") (:form . "’") (:end . 246) (:start . 245)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 247) (:start . 246)\n  (:id . 89))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 252) (:start . 248)\n  (:id . 90))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 258)\n  (:start . 253) (:id . 91))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 262) (:start . 259)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 269)\n  (:start . 263) (:id . 93))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 281)\n  (:start . 270) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x2.431.2) (:span 191 197))\n  ((:id . :x2.431.3) (:span 35 42)))\n (:ncues ((:id . :x2.431.1) (:span 154 157)))\n (:hscopes ((:id . :x2.431.2) (:span 43 281))\n  ((:id . :x2.431.3) (:span 35 281)))\n (:nscopes ((:id . :x2.431.1) (:span 154 181)))\n (:identifiers (:sid . :s2.431) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100758@unknown@formal@none@1@S@T=∑e∈Ecse1+|Ei\\Ec|+|Ej\\Ec| where Ec is the set of edges that connect proteins i and j to their common interactors, Ei is the set of edges that involve protein i, se is the score (likelihood ratio) of edge e and Ei\\Ec refers to the set difference of Ei and Ec.@(((:tag . "NNP") (:stem . "T=∑e∈Ecse1+|Ei\\\\Ec|+|Ej\\\\Ec|")\n  (:form . "T=∑e∈Ecse1+|Ei\\\\Ec|+|Ej\\\\Ec|") (:end . 26) (:start . 0)\n  (:id . 42))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 32) (:start . 27)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ec") (:form . "Ec") (:end . 35) (:start . 33)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 46))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "connect") (:form . "connect") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "i") (:form . "i") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "j") (:form . "j") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 94)\n  (:start . 89) (:id . 57))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 113)\n  (:start . 102) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 142) (:start . 138)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 150)\n  (:start . 143) (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 158)\n  (:start . 151) (:id . 69))\n ((:tag . "NN") (:stem . "i") (:form . "i") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "NN") (:stem . "se") (:form . "se") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 167) (:start . 165)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 74))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 177)\n  (:start . 172) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 179) (:start . 178)\n  (:id . 76))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 189)\n  (:start . 179) (:id . 77))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 195)\n  (:start . 190) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 80))\n ((:tag . "NN") (:stem . "edge") (:form . "edge") (:end . 204) (:start . 200)\n  (:id . 81))\n ((:tag . "NN") (:stem . "e") (:form . "e") (:end . 206) (:start . 205)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Ei\\\\Ec") (:form . "Ei\\\\Ec") (:end . 216)\n  (:start . 211) (:id . 84))\n ((:tag . "VBZ") (:stem . "refer") (:form . "refers") (:end . 223)\n  (:start . 217) (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 234) (:start . 231)\n  (:id . 88))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 245)\n  (:start . 235) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 248) (:start . 246)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 251) (:start . 249)\n  (:id . 91))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 255) (:start . 252)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "Ec") (:form . "Ec") (:end . 258) (:start . 256)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s2.432) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100760@unknown@formal@none@1@S@Additionally, the topology score T of a pair of proteins increases as the proportion of likely interactors that these two proteins share increases.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "interactor") (:form . "interactors") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "share") (:form . "share") (:end . 136)\n  (:start . 131) (:id . 64))\n ((:tag . "NNS") (:stem . "increase") (:form . "increases") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.434) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100761@unknown@formal@none@1@S@The topology scores were grouped into 5 bins of increasing value.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "bin") (:form . "bins") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.435) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100762@unknown@formal@none@1@S@It should be noted that the neighborhood topology score calculated for a given protein pair does not consider the preliminary score assigned to that protein pair.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neighborhood") (:form . "neighborhood") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 66)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "VB") (:stem . "consider") (:form . "consider") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 131)\n  (:start . 126) (:id . 62))\n ((:tag . "VBN") (:stem . "assign") (:form . "assigned") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 156)\n  (:start . 149) (:id . 66))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x2.436.1) (:span 97 100)))\n (:nscopes ((:id . :x2.436.1) (:span 97 161)))\n (:identifiers (:sid . :s2.436) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100763@unknown@formal@none@1@S@It only considers the preliminary scores of its neighbors and so is truly based on the local network topology around that protein pair.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "consider") (:form . "considers") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "preliminary") (:form . "preliminary") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "neighbor") (:form . "neighbors") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "RB") (:stem . "truly") (:form . "truly") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "topology") (:form . "topology") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 129)\n  (:start . 122) (:id . 63))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s2.437) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100764@unknown@formal@none@1@S@Accordingly, the likelihood ratio the transitive module outputs for a given protein pair is independent of the likelihood ratio calculated by the Group A modules for this same protein pair.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "transitive") (:form . "transitive") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "module") (:form . "module") (:end . 55)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "output") (:form . "outputs") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 138)\n  (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Group") (:form . "Group") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 170) (:start . 166)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 175) (:start . 171)\n  (:id . 70))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s2.438) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100765@unknown@formal@none@1@S@Correlation analysis@(((:tag . "NN") (:stem . "correlation") (:form . "Correlation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43)))@@@1@2@((:identifiers (:sid . :s2.439) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100766@unknown@formal@none@1@S@The Pearson correlation between pairs of modules was estimated by taking 150 samples of 10000 protein pairs each and calculating the Pearson correlation of the likelihood ratios for the two modules considered, for each sample.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Pearson") (:form . "Pearson") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 72) (:start . 66)\n  (:id . 52))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "CD") (:stem . "10000") (:form . "10000") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "calculate") (:form . "calculating") (:end . 128)\n  (:start . 117) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Pearson") (:form . "Pearson") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 152)\n  (:start . 141) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 170)\n  (:start . 160) (:id . 67))\n ((:tag . "NNS") (:stem . "ratio") (:form . "ratios") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 197)\n  (:start . 190) (:id . 72))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 208)\n  (:start . 198) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 213) (:start . 210)\n  (:id . 75))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 218) (:start . 214)\n  (:id . 76))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 225)\n  (:start . 219) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s2.440) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100767@unknown@formal@none@1@S@The reported correlation values are the average of the 150 experiments.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s2.441) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100768@unknown@formal@none@1@S@Samples of the protein pair space were taken instead of considering the whole space as this was more computationally tractable.@(((:tag . "NNS") (:stem . "sample") (:form . "Samples") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "computationally") (:form . "computationally")\n  (:end . 116) (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "tractable") (:form . "tractable") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x2.442.1) (:span 45 55)))\n (:nscopes ((:id . :x2.442.1) (:span 45 83)))\n (:identifiers (:sid . :s2.442) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100770@unknown@formal@none@1@S@The accuracy of the predictors was measured by performing five-fold cross validation experiments in which the datasets were randomly divided into five non-overlapping sets, four of which were used to train the predictor while the fifth was used to test the prediction accuracy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "perform") (:form . "performing") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "five-fold") (:form . "five-fold") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "cross") (:form . "cross") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 84)\n  (:start . 74) (:id . 53))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 132)\n  (:start . 124) (:id . 60))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 150) (:start . 146)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "non-overlapping") (:form . "non-overlapping")\n  (:end . 166) (:start . 151) (:id . 64))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 177) (:start . 173)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 186)\n  (:start . 181) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 191) (:start . 187)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "VB") (:stem . "train") (:form . "train") (:end . 205)\n  (:start . 200) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 74))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 219)\n  (:start . 210) (:id . 75))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 225)\n  (:start . 220) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 77))\n ((:tag . "NN") (:stem . "fifth") (:form . "fifth") (:end . 235)\n  (:start . 230) (:id . 78))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 239) (:start . 236)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 244) (:start . 240)\n  (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 247) (:start . 245)\n  (:id . 81))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 252) (:start . 248)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 256) (:start . 253)\n  (:id . 83))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 267)\n  (:start . 257) (:id . 84))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 276)\n  (:start . 268) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s2.444) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100771@unknown@formal@none@1@S@The accuracy reported is the average measured for all combinations of training and testing sets using these five sets.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 66)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s2.445) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100772@unknown@formal@none@1@S@Testing was done by predicting the total likelihood scores for all protein pairs in the test set using the models computed in the training phase and then counting the number of pairs that were well predicted.@(((:tag . "NNP") (:stem . "Testing") (:form . "Testing") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "predict") (:form . "predicting") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "likelihood") (:form . "likelihood") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "phase") (:form . "phase") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "count") (:form . "counting") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 173)\n  (:start . 167) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 182)\n  (:start . 177) (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 192) (:start . 188)\n  (:id . 75))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 197) (:start . 193)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 207)\n  (:start . 198) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s2.446) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100773@unknown@formal@none@1@S@We used the area under partial ROC curves as a measure of accuracy.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "area") (:form . "area") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NNP") (:stem . "ROC") (:form . "ROC") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 66)\n  (:start . 58) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s2.447) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100774@unknown@formal@none@1@S@Receiver operator characteristic (ROC) curves plot the true positive rate versus the false positive rate over their full range of possible values.@(((:tag . "NN") (:stem . "receiver") (:form . "Receiver") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "operator") (:form . "operator") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 32) (:start . 18) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 34) (:start . 33)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ROC") (:form . "ROC") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "curve") (:form . "curves") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "plot") (:form . "plot") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 99)\n  (:start . 91) (:id . 57))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s2.448) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100775@unknown@formal@none@1@S@In some circumstances, it is more informative to use partial ROC curves (ROCn curves) which illustrate the number of true positives identified by the predictor that score higher than the n highest scoring negatives, plotted for all values from 0 to n.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "circumstance") (:form . "circumstances")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "informative") (:form . "informative") (:end . 45)\n  (:start . 34) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NNP") (:stem . "ROC") (:form . "ROC") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ROCn") (:form . "ROCn") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "illustrate") (:form . "illustrate") (:end . 102)\n  (:start . 92) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 131)\n  (:start . 122) (:id . 65))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 142)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 159)\n  (:start . 150) (:id . 69))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "score") (:form . "score") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 177)\n  (:start . 171) (:id . 72))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 74))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 196)\n  (:start . 189) (:id . 76))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 204)\n  (:start . 197) (:id . 77))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 214)\n  (:start . 205) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "plot") (:form . "plotted") (:end . 223)\n  (:start . 216) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 227) (:start . 224)\n  (:id . 81))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 231) (:start . 228)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 238)\n  (:start . 232) (:id . 83))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 243) (:start . 239)\n  (:id . 84))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 245) (:start . 244)\n  (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 248) (:start . 246)\n  (:id . 86))\n ((:tag . "NN") (:stem . "n") (:form . "n") (:end . 250) (:start . 249)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s2.449) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100776@unknown@formal@none@1@S@There are many more negatives than positives in our datasets and this is also thought to be true for the full protein interaction networks we are modeling.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 129)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "model") (:form . "modeling") (:end . 154)\n  (:start . 146) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x2.450.1) (:span 78 85)))\n (:hscopes ((:id . :x2.450.1) (:span 78 154)))\n (:identifiers (:sid . :s2.450) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100777@unknown@formal@none@1@S@Since the aim is to identify the largest number of true interacting pairs while leaving out as many non-interacting pairs as possible, it is most informative to measure the performance of the predictor under conditions of very low false-positive rates.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "aim") (:form . "aim") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "large") (:form . "largest") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "leave") (:form . "leaving") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 115) (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "informative") (:form . "informative") (:end . 157)\n  (:start . 146) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "VB") (:stem . "measure") (:form . "measure") (:end . 168)\n  (:start . 161) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 71))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 184)\n  (:start . 173) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "NN") (:stem . "predictor") (:form . "predictor") (:end . 201)\n  (:start . 192) (:id . 75))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 207)\n  (:start . 202) (:id . 76))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 218)\n  (:start . 208) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 221) (:start . 219)\n  (:id . 78))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 226) (:start . 222)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 230) (:start . 227)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "false-positive") (:form . "false-positive")\n  (:end . 245) (:start . 231) (:id . 81))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 251)\n  (:start . 246) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s2.451) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100778@unknown@formal@none@1@S@Accordingly, ROC50 and ROC100 curves were analyzed because given the size of the datasets, these curves consider all the protein pairs predicted to have a posterior odds ratio above 1.0, for all the predictors investigated.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ROC50") (:form . "ROC50") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ROC100") (:form . "ROC100") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "posterior") (:form . "posterior") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . "NNS") (:stem . "odd") (:form . "odds") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 181)\n  (:start . 176) (:id . 72))\n ((:tag . "CD") (:stem . "1.0") (:form . "1.0") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 190) (:start . 187)\n  (:id . 75))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 194) (:start . 191)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "predictor") (:form . "predictors") (:end . 209)\n  (:start . 199) (:id . 78))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 222)\n  (:start . 210) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s2.452) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100780@unknown@formal@none@1@S@For ROCn curves, it can be calculated as AUC ROCn = 1nT∗(∑i=1nTi) where i takes on values from 1 to n, T is the total number of positives in the test set and Ti is the number of positives that score higher than the ith highest scoring negative.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ROCn") (:form . "ROCn") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "curve") (:form . "curves") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "calculate") (:form . 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"of") (:end . 177) (:start . 175)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 187)\n  (:start . 178) (:id . 82))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 83))\n ((:tag . "VBP") (:stem . "score") (:form . "score") (:end . 198)\n  (:start . 193) (:id . 84))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 205)\n  (:start . 199) (:id . 85))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 210) (:start . 206)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 87))\n ((:tag . "NN") (:stem . "ith") (:form . "ith") (:end . 218) (:start . 215)\n  (:id . 88))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 226)\n  (:start . 219) (:id . 89))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 234)\n  (:start . 227) (:id . 90))\n ((:tag . "JJ") (:stem . "negative") (:form . "negative") (:end . 243)\n  (:start . 235) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s2.454) (:did . :1471-2105-8-239)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100781@unknown@formal@none@1@S@A novel ensemble learning method for de novo computational identification of DNA binding sites@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 58) (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 73) (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 88)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 94) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.1) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100782@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.2) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100783@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.3) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100784@unknown@formal@none@1@S@Despite the diversity of motif representations and search algorithms, the de novo computational identification of transcription factor binding sites remains constrained by the limited accuracy of existing algorithms and the need for user-specified input parameters that describe the motif being sought.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "representation") (:form . "representations")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 95) (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 110) (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 127) (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 134)\n  (:start . 128) (:id . 59))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 142)\n  (:start . 135) (:id . 60))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 148)\n  (:start . 143) (:id . 61))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 156)\n  (:start . 149) (:id . 62))\n ((:tag . "VBN") (:stem . "constrain") (:form . "constrained") (:end . 168)\n  (:start . 157) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 183)\n  (:start . 176) (:id . 66))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 192)\n  (:start . 184) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 195) (:start . 193)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 204)\n  (:start . 196) (:id . 69))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 215)\n  (:start . 205) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 72))\n ((:tag . "NN") (:stem . "need") (:form . "need") (:end . 228) (:start . 224)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 232) (:start . 229)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "user-specified") (:form . "user-specified")\n  (:end . 247) (:start . 233) (:id . 75))\n ((:tag . "NN") (:stem . "input") (:form . "input") (:end . 253)\n  (:start . 248) (:id . 76))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 264)\n  (:start . 254) (:id . 77))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 269) (:start . 265)\n  (:id . 78))\n ((:tag . "VBP") (:stem . "describe") (:form . "describe") (:end . 278)\n  (:start . 270) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 282) (:start . 279)\n  (:id . 80))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 288)\n  (:start . 283) (:id . 81))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 294) (:start . 289)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "seek") (:form . "sought") (:end . 301)\n  (:start . 295) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 302) (:start . 301)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s3.4) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100785@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.5) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100786@unknown@formal@none@1@S@We present a novel ensemble learning method, SCOPE, that is based on the assumption that transcription factor binding sites belong to one of three broad classes of motifs:: non-degenerate, degenerate and gapped motifs.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 65) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 83)\n  (:start . 73) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 102) (:start . 89) (:id . 59))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 130)\n  (:start . 124) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "JJ") (:stem . "broad") (:form . "broad") (:end . 152)\n  (:start . 147) (:id . 68))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 160)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 170)\n  (:start . 164) (:id . 71))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 172) (:start . 171)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "non-degenerate") (:form . "non-degenerate")\n  (:end . 187) (:start . 173) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 199)\n  (:start . 189) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "gapped") (:form . "gapped") (:end . 210)\n  (:start . 204) (:id . 78))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 217)\n  (:start . 211) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x3.6.1) (:span 73 83)))\n (:hscopes ((:id . :x3.6.1) (:span 73 217)))\n (:identifiers (:sid . :s3.6) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100787@unknown@formal@none@1@S@SCOPE employs a unified scoring metric to combine the results from three motif finding algorithms each aimed at the discovery of one of these classes of motifs.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "employ") (:form . "employs") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "unified") (:form . "unified") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "metric") (:form . "metric") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "combine") (:form . "combine") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "aim") (:form . "aimed") (:end . 108) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 125)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 141)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 149)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.7) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100788@unknown@formal@none@1@S@We found that SCOPE's performance on 78 experimentally characterized regulons from four species was a substantial and statistically significant improvement over that of its component algorithms.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 54) (:start . 40) (:id . 50))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 68) (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 95)\n  (:start . 88) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 99) (:start . 96)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 113)\n  (:start . 102) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 131) (:start . 118) (:id . 60))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 143)\n  (:start . 132) (:id . 61))\n ((:tag . "NN") (:stem . "improvement") (:form . "improvement") (:end . 155)\n  (:start . 144) (:id . 62))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 160) (:start . 156)\n  (:id . 63))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 165) (:start . 161)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 172) (:start . 169)\n  (:id . 66))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 182)\n  (:start . 173) (:id . 67))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 193)\n  (:start . 183) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.8) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100790@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.10) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100791@unknown@formal@none@1@S@SCOPE demonstrates that combining multiple, focused motif discovery algorithms can provide a significant gain in performance.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "focused") (:form . "focused") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 82) (:start . 79)\n  (:id . 52))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 104)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "gain") (:form . "gain") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 124)\n  (:start . 113) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.11) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100792@unknown@formal@none@1@S@By building on components that efficiently search for motifs without user-defined parameters, SCOPE requires as input only a set of upstream sequences and a species designation, making it a practical choice for non-expert users.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "build") (:form . "building") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "VBP") (:stem . "search") (:form . "search") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "JJ") (:stem . "user-defined") (:form . "user-defined") (:end . 81)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 92)\n  (:start . 82) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "input") (:form . "input") (:end . 117)\n  (:start . 112) (:id . 58))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 122) (:start . 118)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 128) (:start . 125)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 164)\n  (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "designation") (:form . "designation") (:end . 176)\n  (:start . 165) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 189) (:start . 188)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "practical") (:form . "practical") (:end . 199)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "choice") (:form . "choice") (:end . 206)\n  (:start . 200) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 210) (:start . 207)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "non-expert") (:form . "non-expert") (:end . 221)\n  (:start . 211) (:id . 76))\n ((:tag . "NNS") (:stem . "user") (:form . "users") (:end . 227)\n  (:start . 222) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x3.12.1) (:span 61 68)))\n (:nscopes ((:id . :x3.12.1) (:span 61 92)))\n (:identifiers (:sid . :s3.12) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100793@unknown@formal@none@1@S@A user-friendly web interface, Java source code and executables are available at http://genie.dartmouth.edu/scope.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "user-friendly") (:form . "user-friendly")\n  (:end . 15) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "web") (:form . "web") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interface") (:form . "interface") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Java") (:form . "Java") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "executable") (:form . "executables") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "http://genie.dartmouth.edu/scope")\n  (:form . "http://genie.dartmouth.edu/scope") (:end . 113) (:start . 81)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s3.13) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100794@unknown@formal@none@1@S@Backgound@(((:tag . "NNP") (:stem . "Backgound") (:form . "Backgound") (:end . 9)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.14) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100795@unknown@formal@none@1@S@The computational discovery of DNA binding sites for previously uncharacterized transcription factors in groups of co-regulated genes is a well-studied problem with a great deal of practical relevance to the biologist, since such binding sites provide targets for mutational analyses (for reviews see 123).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . 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5100796@unknown@formal@none@1@S@The position-specific variability of transcription factor binding sites makes their de novo identification challenging.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "position-specific") (:form . "position-specific")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "variability") (:form . "variability") (:end . 33)\n  (:start . 22) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 50) (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 57)\n  (:start . 51) (:id . 47))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 65)\n  (:start . 58) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 71) (:start . 66)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "make") (:form . "makes") (:end . 77) (:start . 72)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 83)\n  (:start . 78) (:id . 51))\n ((:tag . "FW") (:stem . "de") (:form . "de") (:end . 86) (:start . 84)\n  (:id . 52))\n ((:tag . "FW") (:stem . "novo") (:form . "novo") (:end . 91) (:start . 87)\n  (:id . 53))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 106) (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "challenging") (:form . "challenging") (:end . 118)\n  (:start . 107) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s3.16) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100797@unknown@formal@none@1@S@Many computational motif finding methods are based on the observation that transcription factor binding sites occur more often than expected by chance in the upstream regions of the set of genes regulated by the same transcription factor 1.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 44) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 115)\n  (:start . 110) (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 126)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 143) (:start . 141)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 150)\n  (:start . 144) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 194)\n  (:start . 189) (:id . 72))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 204)\n  (:start . 195) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 216) (:start . 212)\n  (:id . 76))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 230) (:start . 217) (:id . 77))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 237)\n  (:start . 231) (:id . 78))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 239) (:start . 238)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s3.17) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100798@unknown@formal@none@1@S@The problem thus simplifies to the identification of overrepresented motifs in a given set of upstream sequences.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "simplify") (:form . "simplifies") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 49) (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "overrepresented") (:form . "overrepresented")\n  (:end . 68) (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.18) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100800@unknown@formal@none@1@S@Most recent programs represent motifs as position weight matrices (PWMs), which record the frequency of each base at every position in the motif.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "matrix") (:form . "matrices") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PWM") (:form . "PWMs") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "record") (:form . "record") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 144)\n  (:start . 139) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s3.20) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100801@unknown@formal@none@1@S@Other motif finding programs have relied on the use of consensus motif models (in which every base is represented by a letter of the 15-letter IUPAC code, which accounts for degeneracies as well as single bases) or k-mismatch motif models (in which a non-degenerate word with at most k allowed mismatches is used to represent the word).@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "rely") (:form . "relied") (:end . 40) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 113)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "letter") (:form . "letter") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "15-letter") (:form . "15-letter") (:end . 142)\n  (:start . 133) (:id . 67))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 153) (:start . 149)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . "VBZ") (:stem . "account") (:form . "accounts") (:end . 169)\n  (:start . 161) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "degeneracy") (:form . "degeneracies") (:end . 186)\n  (:start . 174) (:id . 74))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 189) (:start . 187)\n  (:id . 75))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 194) (:start . 190)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 197) (:start . 195)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 204)\n  (:start . 198) (:id . 78))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 210)\n  (:start . 205) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 211) (:start . 210)\n  (:id . 80))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 214) (:start . 212)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "k-mismatch") (:form . "k-mismatch") (:end . 225)\n  (:start . 215) (:id . 82))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 231)\n  (:start . 226) (:id . 83))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 238)\n  (:start . 232) (:id . 84))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 240) (:start . 239)\n  (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 242) (:start . 240)\n  (:id . 86))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 248)\n  (:start . 243) (:id . 87))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 250) (:start . 249)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "non-degenerate") (:form . "non-degenerate")\n  (:end . 265) (:start . 251) (:id . 89))\n ((:tag . "NN") (:stem . "word") (:form . "word") (:end . 270) (:start . 266)\n  (:id . 90))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 275) (:start . 271)\n  (:id . 91))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 278) (:start . 276)\n  (:id . 92))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 283) (:start . 279)\n  (:id . 93))\n ((:tag . "NN") (:stem . "k") (:form . "k") (:end . 285) (:start . 284)\n  (:id . 94))\n ((:tag . "VBN") (:stem . "allow") (:form . "allowed") (:end . 293)\n  (:start . 286) (:id . 95))\n ((:tag . "NNS") (:stem . "mismatch") (:form . "mismatches") (:end . 304)\n  (:start . 294) (:id . 96))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 307) (:start . 305)\n  (:id . 97))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 312) (:start . 308)\n  (:id . 98))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 315) (:start . 313)\n  (:id . 99))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 325)\n  (:start . 316) (:id . 100))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 329) (:start . 326)\n  (:id . 101))\n ((:tag . "NN") (:stem . "word") (:form . "word") (:end . 334) (:start . 330)\n  (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 335) (:start . 334)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 336) (:start . 335)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s3.21) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100802@unknown@formal@none@1@S@Regardless of the motif model used, a search for all overrepresented motifs of any length and degree of degeneracy leads to a dauntingly large search space.@(((:tag . "RB") (:stem . "regardless") (:form . "Regardless") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "overrepresented") (:form . "overrepresented")\n  (:end . 68) (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 89)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "degeneracy") (:form . "degeneracy") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "RB") (:stem . "dauntingly") (:form . "dauntingly") (:end . 136)\n  (:start . 126) (:id . 65))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.22) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100803@unknown@formal@none@1@S@Thus, motif finding algorithms restrict their search space by using simplified motif representations, employing heuristic search strategies that are prone to local optima, or invoking additional parameters to limit the search space and thereby pass some of the optimization process off to the user 3.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "restrict") (:form . "restrict") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 45)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "simplified") (:form . "simplified") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "representation") (:form . "representations")\n  (:end . 100) (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "employ") (:form . "employing") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "JJ") (:stem . "heuristic") (:form . "heuristic") (:end . 121)\n  (:start . 112) (:id . 58))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 128)\n  (:start . 122) (:id . 59))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 139)\n  (:start . 129) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 148) (:start . 145)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "prone") (:form . "prone") (:end . 154)\n  (:start . 149) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 163)\n  (:start . 158) (:id . 65))\n ((:tag . "NNS") (:stem . "optimum") (:form . "optima") (:end . 170)\n  (:start . 164) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "invoke") (:form . "invoking") (:end . 183)\n  (:start . 175) (:id . 69))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 194)\n  (:start . 184) (:id . 70))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 205)\n  (:start . 195) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "VB") (:stem . "limit") (:form . "limit") (:end . 214)\n  (:start . 209) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 225)\n  (:start . 219) (:id . 75))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 231)\n  (:start . 226) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 77))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 243)\n  (:start . 236) (:id . 78))\n ((:tag . "VBP") (:stem . "pass") (:form . "pass") (:end . 248) (:start . 244)\n  (:id . 79))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 253) (:start . 249)\n  (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 256) (:start . 254)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 260) (:start . 257)\n  (:id . 82))\n ((:tag . "NN") (:stem . "optimization") (:form . "optimization") (:end . 273)\n  (:start . 261) (:id . 83))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 281)\n  (:start . 274) (:id . 84))\n ((:tag . "IN") (:stem . "off") (:form . "off") (:end . 285) (:start . 282)\n  (:id . 85))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 288) (:start . 286)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 292) (:start . 289)\n  (:id . 87))\n ((:tag . "NN") (:stem . "user") (:form . "user") (:end . 297) (:start . 293)\n  (:id . 88))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 299) (:start . 298)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 300) (:start . 299)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s3.23) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100804@unknown@formal@none@1@S@Program parameters (such as motif length, number of occurrences and orientation) that cannot be reasonably specified by the user without prior knowledge about the true binding sites are referred to as nuisance parameters 4.@(((:tag . "NN") (:stem . "program") (:form . "Program") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "occurrence") (:form . "occurrences") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "RB") (:stem . "reasonably") (:form . "reasonably") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "VBN") (:stem . "specify") (:form . "specified") (:end . 116)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "user") (:form . "user") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 152)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 175)\n  (:start . 168) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 181)\n  (:start . 176) (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 200) (:start . 198)\n  (:id . 75))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 209)\n  (:start . 201) (:id . 76))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 220)\n  (:start . 210) (:id . 77))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 222) (:start . 221)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x3.24.1) (:span 129 136)) ((:id . :x3.24.2) (:span 86 92)))\n (:nscopes ((:id . :x3.24.1) (:span 129 181))\n  ((:id . :x3.24.2) (:span 81 181)))\n (:identifiers (:sid . :s3.24) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100805@unknown@formal@none@1@S@Selection of the correct settings for these parameters is a crucial step in motif finding, and is often assumed to be the domain of experts.@(((:tag . "NN") (:stem . "selection") (:form . "Selection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 103) (:start . 98)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 128)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "expert") (:form . "experts") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x3.25.1) (:span 104 111)))\n (:hscopes ((:id . :x3.25.1) (:span 95 139)))\n (:identifiers (:sid . :s3.25) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100806@unknown@formal@none@1@S@In a recent evaluation, Hu and colleagues 4 compared the performance of five motif finders on a single prokaryotic genome, systematically exploring the effects of nuisance parameters, including expected motif length and number of occurrences.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Hu") (:form . "Hu") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "colleague") (:form . "colleagues") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 68)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "JJ") (:stem . "prokaryotic") (:form . "prokaryotic") (:end . 114)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "RB") (:stem . "systematically") (:form . "systematically")\n  (:end . 137) (:start . 123) (:id . 64))\n ((:tag . "VBG") (:stem . "explore") (:form . "exploring") (:end . 147)\n  (:start . 138) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 159)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 182)\n  (:start . 172) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 193)\n  (:start . 184) (:id . 72))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 202)\n  (:start . 194) (:id . 73))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 208)\n  (:start . 203) (:id . 74))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 215)\n  (:start . 209) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 226)\n  (:start . 220) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "occurrence") (:form . "occurrences") (:end . 241)\n  (:start . 230) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s3.26) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100807@unknown@formal@none@1@S@Every motif finder they tested was found to be sensitive to values used for these parameters.@(((:tag . "DT") (:stem . "every") (:form . "Every") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 30) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 92)\n  (:start . 82) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s3.27) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100808@unknown@formal@none@1@S@Guidance on the specific parameter settings to use for given motif finding situations is not provided in most publications presenting motif finders.@(((:tag . "NN") (:stem . "guidance") (:form . "Guidance") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 43)\n  (:start . 35) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "situation") (:form . "situations") (:end . 85)\n  (:start . 75) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "publication") (:form . "publications") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . "VBG") (:stem . "present") (:form . "presenting") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x3.28.1) (:span 89 92)))\n (:nscopes ((:id . :x3.28.1) (:span 0 147)))\n (:identifiers (:sid . :s3.28) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100810@unknown@formal@none@1@S@Nuisance parameters complicate the interpretation of performance comparisons as well.@(((:tag . "NN") (:stem . "nuisance") (:form . "Nuisance") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "complicate") (:form . "complicate") (:end . 30)\n  (:start . 20) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 45))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 49) (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 47))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 64)\n  (:start . 53) (:id . 48))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 76)\n  (:start . 65) (:id . 49))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s3.30) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100811@unknown@formal@none@1@S@A recent large-scale performance comparison between thirteen different motif finding tools used expert knowledge in setting the parameters for every program 5.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "large-scale") (:form . "large-scale") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 43)\n  (:start . 33) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "CD") (:stem . "thirteen") (:form . "thirteen") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 76) (:start . 71)\n  (:id . 50))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . "NNS") (:stem . "tool") (:form . "tools") (:end . 90) (:start . 85)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 95) (:start . 91)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "expert") (:form . "expert") (:end . 102)\n  (:start . 96) (:id . 54))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 112)\n  (:start . 103) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "set") (:form . "setting") (:end . 123)\n  (:start . 116) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 138)\n  (:start . 128) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 142) (:start . 139)\n  (:id . 60))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 148)\n  (:start . 143) (:id . 61))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 156)\n  (:start . 149) (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 158) (:start . 157)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.31) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100812@unknown@formal@none@1@S@Several of the programs contributing to the performance comparison were run with different parameter settings for each regulon, and in some cases, motifs were hand filtered as a post-processing step.@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBG") (:stem . "contribute") (:form . "contributing") (:end . 36)\n  (:start . 24) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 71) (:start . 67)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "run") (:form . "run") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 163) (:start . 159)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 172)\n  (:start . 164) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "post-processing") (:form . "post-processing")\n  (:end . 193) (:start . 178) (:id . 72))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 198) (:start . 194)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s3.32) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100813@unknown@formal@none@1@S@Such performance comparisons evaluate not just algorithms but also the expertise of the users, making it difficult for a first-time user to select a motif finder on a principled basis.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 28)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "evaluate") (:form . "evaluate") (:end . 37)\n  (:start . 29) (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expertise") (:form . "expertise") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "user") (:form . "users") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "first-time") (:form . "first-time") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "user") (:form . "user") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 64))\n ((:tag . "VB") (:stem . "select") (:form . "select") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 154)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 161)\n  (:start . 155) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "principled") (:form . "principled") (:end . 177)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 183)\n  (:start . 178) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s3.33) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100814@unknown@formal@none@1@S@A key result of the Tompa, et al. study was the finding that all of the motif finders had roughly the same average performance under a wide range of conditions and test statistics 5.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 12) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Tompa") (:form . "Tompa") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 39) (:start . 34)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 53))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 55)\n  (:start . 48) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 64) (:start . 61)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 77) (:start . 72)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 85)\n  (:start . 78) (:id . 60))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 89) (:start . 86)\n  (:id . 61))\n ((:tag . "RB") (:stem . "roughly") (:form . "roughly") (:end . 97)\n  (:start . 90) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 106) (:start . 102)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 114)\n  (:start . 107) (:id . 65))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 126)\n  (:start . 115) (:id . 66))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 132)\n  (:start . 127) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 139) (:start . 135)\n  (:id . 69))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 145)\n  (:start . 140) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 159)\n  (:start . 149) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 73))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 168) (:start . 164)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 179)\n  (:start . 169) (:id . 75))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 181) (:start . 180)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s3.34) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100815@unknown@formal@none@1@S@This finding was particularly notable because the motif finders studied employed a wide range of motif representations, scoring functions and search strategies and all were operated under the most favorable conditions possible.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 29)\n  (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "notable") (:form . "notable") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "VBD") (:stem . "employ") (:form . "employed") (:end . 80)\n  (:start . 72) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 93) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 102) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "representation") (:form . "representations")\n  (:end . 118) (:start . 103) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 137)\n  (:start . 128) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 62))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 148)\n  (:start . 142) (:id . 63))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 159)\n  (:start . 149) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 167) (:start . 164)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "operate") (:form . "operated") (:end . 181)\n  (:start . 173) (:id . 68))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 187)\n  (:start . 182) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 70))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "favorable") (:form . "favorable") (:end . 206)\n  (:start . 197) (:id . 72))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 217)\n  (:start . 207) (:id . 73))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 226)\n  (:start . 218) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s3.35) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100816@unknown@formal@none@1@S@Although the average performance of the programs did not differ significantly, the authors found that, for each pair of programs, each program performed better than the other on some subset of the data 5.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 142)\n  (:start . 135) (:id . 66))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 174)\n  (:start . 169) (:id . 71))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 182) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 189)\n  (:start . 183) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 196) (:start . 193)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 201)\n  (:start . 197) (:id . 77))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 203) (:start . 202)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s3.36) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100817@unknown@formal@none@1@S@Previous studies over smaller numbers of motif finders have found that no program clearly stands out as superior to the others and each program outperforms all others on some subset of the regulons 678.@(((:tag . "JJ") (:stem . "previous") (:form . "Previous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "VBZ") (:stem . "stand") (:form . "stands") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "superior") (:form . "superior") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . "VBZ") (:stem . "outperform") (:form . "outperforms") (:end . 155)\n  (:start . 144) (:id . 66))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 174) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 181)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . "CD") (:stem . "678") (:form . "678") (:end . 201) (:start . 198)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x3.37.1) (:span 71 73)))\n (:nscopes ((:id . :x3.37.1) (:span 71 126)))\n (:identifiers (:sid . :s3.37) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100818@unknown@formal@none@1@S@This diversity of performance has led a number of authors to speculate that ensemble methods, comprising multiple motif finders, may lead to improvements in accuracy 158.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "lead") (:form . "led") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VB") (:stem . "speculate") (:form . "speculate") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "comprise") (:form . "comprising") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "improvement") (:form . "improvements") (:end . 153)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 165)\n  (:start . 157) (:id . 68))\n ((:tag . "CD") (:stem . "158") (:form . "158") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x3.38.1) (:span 129 132)) ((:id . :x3.38.2) (:span 61 70)))\n (:hscopes ((:id . :x3.38.1) (:span 129 165))\n  ((:id . :x3.38.2) (:span 61 165)))\n (:identifiers (:sid . :s3.38) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100820@unknown@formal@none@1@S@The final predictions are chosen from the ensemble of methods by a learning rule, which may be as simple as finding the maximum score from all the methods, or as complex as optimizing a weighted scoring scheme from among the methods.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 104)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 115)\n  (:start . 108) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 127)\n  (:start . 120) (:id . 65))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 133)\n  (:start . 128) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 138) (:start . 134)\n  (:id . 67))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 154)\n  (:start . 147) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 161) (:start . 159)\n  (:id . 73))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 169)\n  (:start . 162) (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 172) (:start . 170)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "optimize") (:form . "optimizing") (:end . 183)\n  (:start . 173) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 185) (:start . 184)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "weighted") (:form . "weighted") (:end . 194)\n  (:start . 186) (:id . 78))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 202)\n  (:start . 195) (:id . 79))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 209)\n  (:start . 203) (:id . 80))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 214) (:start . 210)\n  (:id . 81))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 220)\n  (:start . 215) (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 232)\n  (:start . 225) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x3.40.1) (:span 88 91)))\n (:hscopes ((:id . :x3.40.1) (:span 88 232)))\n (:identifiers (:sid . :s3.40) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100821@unknown@formal@none@1@S@The construction of this learning rule is key to the performance of an ensemble learning method, as the performance of an ensemble method with an ineffective learning rule will be the average of the performance of its component algorithms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "construction") (:form . "construction") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 64)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 115)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 137)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "ineffective") (:form . "ineffective") (:end . 157)\n  (:start . 146) (:id . 68))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 191)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 76))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 210)\n  (:start . 199) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 78))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 217) (:start . 214)\n  (:id . 79))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 227)\n  (:start . 218) (:id . 80))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 238)\n  (:start . 228) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s3.41) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100822@unknown@formal@none@1@S@In this context, we note that Tompa et al. 5 found that, although every motif finding program tested had some regulons on which its performance was clearly superior, it was not possible a priori to predict which motif finder represented the best choice under any given set of conditions 5.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "note") (:form . "note") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Tompa") (:form . "Tompa") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 44) (:start . 43)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 50) (:start . 45)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 55))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 65)\n  (:start . 57) (:id . 56))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 71) (:start . 66)\n  (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 77) (:start . 72)\n  (:id . 58))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 85)\n  (:start . 78) (:id . 59))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 100)\n  (:start . 94) (:id . 61))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 109) (:start . 105)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 118)\n  (:start . 110) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 131) (:start . 128)\n  (:id . 67))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 143)\n  (:start . 132) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 147) (:start . 144)\n  (:id . 69))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 155)\n  (:start . 148) (:id . 70))\n ((:tag . "JJ") (:stem . "superior") (:form . "superior") (:end . 164)\n  (:start . 156) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 172) (:start . 169)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 176) (:start . 173)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 185)\n  (:start . 177) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 187) (:start . 186)\n  (:id . 77))\n ((:tag . "NN") (:stem . "priori") (:form . "priori") (:end . 194)\n  (:start . 188) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 197) (:start . 195)\n  (:id . 79))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 205)\n  (:start . 198) (:id . 80))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 211)\n  (:start . 206) (:id . 81))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 217)\n  (:start . 212) (:id . 82))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 224)\n  (:start . 218) (:id . 83))\n ((:tag . "VBD") (:stem . "represent") (:form . "represented") (:end . 236)\n  (:start . 225) (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 240) (:start . 237)\n  (:id . 85))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 245) (:start . 241)\n  (:id . 86))\n ((:tag . "NN") (:stem . "choice") (:form . "choice") (:end . 252)\n  (:start . 246) (:id . 87))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 258)\n  (:start . 253) (:id . 88))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 262) (:start . 259)\n  (:id . 89))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 268)\n  (:start . 263) (:id . 90))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 272) (:start . 269)\n  (:id . 91))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 275) (:start . 273)\n  (:id . 92))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 286)\n  (:start . 276) (:id . 93))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 288) (:start . 287)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 289) (:start . 288)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x3.42.1) (:span 177 185)))\n (:ncues ((:id . :x3.42.2) (:span 173 176)))\n (:hscopes ((:id . :x3.42.1) (:span 177 286)))\n (:nscopes ((:id . :x3.42.2) (:span 173 286)))\n (:identifiers (:sid . :s3.42) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100823@unknown@formal@none@1@S@This observation serves to illustrate the challenges to the construction of an effective learning rule.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 23)\n  (:start . 17) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "VB") (:stem . "illustrate") (:form . "illustrate") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "challenge") (:form . "challenges") (:end . 52)\n  (:start . 42) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "construction") (:form . "construction") (:end . 72)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.43) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100824@unknown@formal@none@1@S@To the best of our knowledge, only one study to date has explored ensemble learning in motif finding.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 52) (:start . 48)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "explore") (:form . "explored") (:end . 65)\n  (:start . 57) (:id . 55))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 74)\n  (:start . 66) (:id . 56))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 92) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 100)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s3.44) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100825@unknown@formal@none@1@S@Hu, Li and Kihara 4 described a simple ensemble method wherein the component programs were random restarts of the same stochastic algorithm (such as Gibbs sampling or Expectation Maximization) and the learning rule was a voting scheme in which the results of each random restart cast a "vote" for which positions in the DNA sequence should be part of the final reported motif (hereafter, we refer to this as the HLK method).@(((:tag . "NNP") (:stem . "Hu") (:form . "Hu") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NNP") (:stem . "Li") (:form . "Li") (:end . 6) (:start . 4)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Kihara") (:form . "Kihara") (:end . 17)\n  (:start . 11) (:id . 46))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "describe") (:form . "described") (:end . 29)\n  (:start . 20) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 38)\n  (:start . 32) (:id . 50))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "IN") (:stem . "wherein") (:form . "wherein") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "restart") (:form . "restarts") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "stochastic") (:form . "stochastic") (:end . 129)\n  (:start . 119) (:id . 63))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Gibb") (:form . "Gibbs") (:end . 154)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "sampling") (:form . "sampling") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Expectation") (:form . "Expectation") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . "NNP") (:stem . "Maximization") (:form . "Maximization")\n  (:end . 191) (:start . 179) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 192) (:start . 191)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 75))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 209)\n  (:start . 201) (:id . 76))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 214) (:start . 210)\n  (:id . 77))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 218) (:start . 215)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 220) (:start . 219)\n  (:id . 79))\n ((:tag . "NN") (:stem . "voting") (:form . "voting") (:end . 227)\n  (:start . 221) (:id . 80))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 234)\n  (:start . 228) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 243)\n  (:start . 238) (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 255)\n  (:start . 248) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 258) (:start . 256)\n  (:id . 86))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 263) (:start . 259)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 270)\n  (:start . 264) (:id . 88))\n ((:tag . "NN") (:stem . "restart") (:form . "restart") (:end . 278)\n  (:start . 271) (:id . 89))\n ((:tag . "VBD") (:stem . "cast") (:form . "cast") (:end . 283) (:start . 279)\n  (:id . 90))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 285) (:start . 284)\n  (:id . 91))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 287) (:start . 286)\n  (:id . 92))\n ((:tag . "NN") (:stem . "vote") (:form . "vote") (:end . 291) (:start . 287)\n  (:id . 93))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 292) (:start . 291)\n  (:id . 94))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 296) (:start . 293)\n  (:id . 95))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 302)\n  (:start . 297) (:id . 96))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 312)\n  (:start . 303) (:id . 97))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 315) (:start . 313)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 319) (:start . 316)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 323) (:start . 320)\n  (:id . 100))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 332)\n  (:start . 324) (:id . 101))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 339)\n  (:start . 333) (:id . 102))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 342) (:start . 340)\n  (:id . 103))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 347) (:start . 343)\n  (:id . 104))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 350) (:start . 348)\n  (:id . 105))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 354) (:start . 351)\n  (:id . 106))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 360)\n  (:start . 355) (:id . 107))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 369)\n  (:start . 361) (:id . 108))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 375)\n  (:start . 370) (:id . 109))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 377) (:start . 376)\n  (:id . 110))\n ((:tag . "RB") (:stem . "hereafter") (:form . "hereafter") (:end . 386)\n  (:start . 377) (:id . 111))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 387) (:start . 386)\n  (:id . 112))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 390) (:start . 388)\n  (:id . 113))\n ((:tag . "VBP") (:stem . "refer") (:form . "refer") (:end . 396)\n  (:start . 391) (:id . 114))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 399) (:start . 397)\n  (:id . 115))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 404) (:start . 400)\n  (:id . 116))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 407) (:start . 405)\n  (:id . 117))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 411) (:start . 408)\n  (:id . 118))\n ((:tag . "NNP") (:stem . "HLK") (:form . "HLK") (:end . 415) (:start . 412)\n  (:id . 119))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 422)\n  (:start . 416) (:id . 120))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 423) (:start . 422)\n  (:id . 121))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 424) (:start . 423)\n  (:id . 122)))@@@1@81@((:identifiers (:sid . :s3.45) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100826@unknown@formal@none@1@S@Under this scheme, the authors found that ensemble learning resulted in an increase in performance ranging from 6 to 45%.@(((:tag . "IN") (:stem . "under") (:form . "Under") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 98)\n  (:start . 87) (:id . 57))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 113) (:start . 112)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.46) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100827@unknown@formal@none@1@S@The HLK voting method provides a framework wherein a number of different motifs finders can be combined under the heuristic that if several motif finders make the same (or overlapping) prediction, then that prediction is accurate.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HLK") (:form . "HLK") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "voting") (:form . "voting") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "wherein") (:form . "wherein") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "heuristic") (:form . "heuristic") (:end . 123)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 145)\n  (:start . 140) (:id . 65))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 153)\n  (:start . 146) (:id . 66))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 169) (:start . 168)\n  (:id . 70))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 183)\n  (:start . 172) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 195)\n  (:start . 185) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 75))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 206) (:start . 202)\n  (:id . 77))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 217)\n  (:start . 207) (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 220) (:start . 218)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x3.47.1) (:span 88 91)))\n (:hscopes ((:id . :x3.47.1) (:span 51 229)))\n (:identifiers (:sid . :s3.47) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100828@unknown@formal@none@1@S@Here we present a novel ensemble motif finder based on a different conceptual approach.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "JJ") (:stem . "conceptual") (:form . "conceptual") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s3.48) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100830@unknown@formal@none@1@S@Thus, our ensemble uses three specialized algorithms whose search spaces restrict them to each of these three local optima (BEAM for non-degenerate motifs, PRISM for degenerate motifs and SPACER for bipartite motifs).@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "specialize") (:form . "specialized") (:end . 41)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "NNS") (:stem . "space") (:form . "spaces") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "VBP") (:stem . "restrict") (:form . "restrict") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "optimum") (:form . "optima") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "non-degenerate") (:form . "non-degenerate")\n  (:end . 147) (:start . 133) (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 183)\n  (:start . 177) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "NN") (:stem . "spacer") (:form . "SPACER") (:end . 194)\n  (:start . 188) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 208)\n  (:start . 199) (:id . 75))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 215)\n  (:start . 209) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 216) (:start . 215)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s3.50) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100831@unknown@formal@none@1@S@We have previously demonstrated that the greedy search strategies employed by each of these methods allow them to reliably search their respective motif domains without the use of nuisance parameters, as the algorithms themselves efficiently optimize the parameters that are typically forced on the users 101112.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 31)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "greedy") (:form . "greedy") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 74)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 91) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 99)\n  (:start . 92) (:id . 56))\n ((:tag . "VBP") (:stem . "allow") (:form . "allow") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 110) (:start . 106)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "RB") (:stem . "reliably") (:form . "reliably") (:end . 122)\n  (:start . 114) (:id . 60))\n ((:tag . "VB") (:stem . "search") (:form . "search") (:end . 129)\n  (:start . 123) (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 152)\n  (:start . 147) (:id . 64))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 168)\n  (:start . 161) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 67))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 188)\n  (:start . 180) (:id . 70))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 199)\n  (:start . 189) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 203) (:start . 201)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 218)\n  (:start . 208) (:id . 75))\n ((:tag . "PRP") (:stem . "themselves") (:form . "themselves") (:end . 229)\n  (:start . 219) (:id . 76))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 241)\n  (:start . 230) (:id . 77))\n ((:tag . "VBP") (:stem . "optimize") (:form . "optimize") (:end . 250)\n  (:start . 242) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 254) (:start . 251)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 265)\n  (:start . 255) (:id . 80))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 270) (:start . 266)\n  (:id . 81))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 274) (:start . 271)\n  (:id . 82))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 284)\n  (:start . 275) (:id . 83))\n ((:tag . "VBN") (:stem . "force") (:form . "forced") (:end . 291)\n  (:start . 285) (:id . 84))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 294) (:start . 292)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 298) (:start . 295)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "user") (:form . "users") (:end . 304)\n  (:start . 299) (:id . 87))\n ((:tag . "CD") (:stem . "101112") (:form . "101112") (:end . 311)\n  (:start . 305) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 312) (:start . 311)\n  (:id . 89)))@@@1@48@((:ncues ((:id . :x3.51.1) (:span 161 168)))\n (:nscopes ((:id . :x3.51.1) (:span 161 199)))\n (:identifiers (:sid . :s3.51) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100832@unknown@formal@none@1@S@The results of these component algorithms are then combined using a learning rule that is simply the maximum score returned by each component algorithm.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "VBN") (:stem . "return") (:form . "returned") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 151)\n  (:start . 142) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.52) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100833@unknown@formal@none@1@S@To make comparisons possible, the motif scores returned by each algorithm are penalized according to the complexity of the motif.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "make") (:form . "make") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "VBN") (:stem . "return") (:form . "returned") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "penalize") (:form . "penalized") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "complexity") (:form . "complexity") (:end . 115)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.53) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100834@unknown@formal@none@1@S@The resulting ensemble algorithm, SCOPE, has no nuisance parameters and performs significantly better than its component algorithms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 67)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "perform") (:form . "performs") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 94) (:start . 81) (:id . 55))\n ((:tag . "RB") (:stem . "better") (:form . "better") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x3.54.1) (:span 45 47)))\n (:nscopes ((:id . :x3.54.1) (:span 45 67)))\n (:identifiers (:sid . :s3.54) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100835@unknown@formal@none@1@S@In addition, we find that SCOPE performs favorably compared to a diverse range of existing methods and is robust to the presence of extraneous sequences in its input.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "perform") (:form . "performs") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "RB") (:stem . "favorably") (:form . "favorably") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "robust") (:form . "robust") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 63))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 128)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 142)\n  (:start . 132) (:id . 66))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 152)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "input") (:form . "input") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s3.55) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100836@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.56) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5100837@unknown@formal@none@1@S@Algorithm@(((:tag . "NNP") (:stem . "Algorithm") (:form . "Algorithm") (:end . 9)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.57) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100838@unknown@formal@none@1@S@SCOPE takes as input a set of sequences U that are upstream of a set of genes G that are thought to be coregulated.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "input") (:form . "input") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 39)\n  (:start . 30) (:id . 49))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 77) (:start . 72)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 79) (:start . 78)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 88) (:start . 85)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 96)\n  (:start . 89) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 102) (:start . 100)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "coregulate") (:form . "coregulated") (:end . 114)\n  (:start . 103) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x3.58.1) (:span 89 96)))\n (:hscopes ((:id . :x3.58.1) (:span 80 114)))\n (:identifiers (:sid . :s3.58) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100840@unknown@formal@none@1@S@In practice, sets of binding sites are represented using a motif.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "practice") (:form . "practice") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 50)\n  (:start . 39) (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.60) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100841@unknown@formal@none@1@S@We have found that simple consensus motifs over the full IUPAC alphabet (a 15-letter code consisting of the bases A,T,C,G and all possible combinations) provide enough representational power to adequately describe Û, while still allowing for an efficient search 34.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "alphabet") (:form . "alphabet") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "15-letter") (:form . "15-letter") (:end . 84)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "NNP") (:stem . "A,T,C,G") (:form . "A,T,C,G") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 151)\n  (:start . 139) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 160)\n  (:start . 153) (:id . 68))\n ((:tag . "JJ") (:stem . "enough") (:form . "enough") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . "JJ") (:stem . "representational") (:form . "representational")\n  (:end . 184) (:start . 168) (:id . 70))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 190)\n  (:start . 185) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 193) (:start . 191)\n  (:id . 72))\n ((:tag . "RB") (:stem . "adequately") (:form . "adequately") (:end . 204)\n  (:start . 194) (:id . 73))\n ((:tag . "VB") (:stem . "describe") (:form . "describe") (:end . 213)\n  (:start . 205) (:id . 74))\n ((:tag . "NN") (:stem . "û") (:form . "Û") (:end . 215) (:start . 214)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 76))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 222)\n  (:start . 217) (:id . 77))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 228)\n  (:start . 223) (:id . 78))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 237)\n  (:start . 229) (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 241) (:start . 238)\n  (:id . 80))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 244) (:start . 242)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 254)\n  (:start . 245) (:id . 82))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 261)\n  (:start . 255) (:id . 83))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 264) (:start . 262)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s3.61) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100842@unknown@formal@none@1@S@While alternative representations, such as position weight matrices (PWMs) are more expressive, their heuristic searches are prone to local optima and often do not perform well in practice \s34111213\s.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "representation") (:form . "representations")\n  (:end . 33) (:start . 18) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 51)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "matrix") (:form . "matrices") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "PWM") (:form . "PWMs") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "expressive") (:form . "expressive") (:end . 94)\n  (:start . 84) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 101)\n  (:start . 96) (:id . 58))\n ((:tag . "JJ") (:stem . "heuristic") (:form . "heuristic") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 120)\n  (:start . 112) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "prone") (:form . "prone") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "optimum") (:form . "optima") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "NN") (:stem . "practice") (:form . "practice") (:end . 188)\n  (:start . 180) (:id . 73))\n ((:tag . "NN") (:stem . "\s") (:form . "\s") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . "CD") (:stem . "34111213") (:form . "34111213") (:end . 198)\n  (:start . 190) (:id . 75))\n ((:tag . "NN") (:stem . "\s") (:form . "\s") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x3.62.2) (:span 125 133)))\n (:ncues ((:id . :x3.62.1) (:span 160 163)))\n (:hscopes ((:id . :x3.62.2) (:span 125 146)))\n (:nscopes ((:id . :x3.62.1) (:span 160 188)))\n (:identifiers (:sid . :s3.62) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100843@unknown@formal@none@1@S@SCOPE has three component algorithms, BEAM, PRISM and SPACER, which search for non-degenerate, short degenerate, and long, highly degenerate and "gapped" motifs, respectively (Figure 1).@(((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "search") (:form . "search") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "non-degenerate") (:form . "non-degenerate")\n  (:end . 93) (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "degenerate") (:form . "degenerate") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 129)\n  (:start . 123) (:id . 65))\n ((:tag . "VB") (:stem . "degenerate") (:form . "degenerate") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "gap") (:form . "gapped") (:end . 152)\n  (:start . 146) (:id . 69))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 174)\n  (:start . 162) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 182)\n  (:start . 176) (:id . 75))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 184) (:start . 183)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s3.63) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100844@unknown@formal@none@1@S@Each motif is scored considering one or both strands and the motif is marked to indicate which calculation scores higher.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "score") (:form . "scored") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "VBG") (:stem . "consider") (:form . "considering") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "strand") (:form . "strands") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 76) (:start . 70)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "calculation") (:form . "calculation") (:end . 106)\n  (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.64) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100845@unknown@formal@none@1@S@The results of the three algorithms are merged and sorted.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "merge") (:form . "merged") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "sort") (:form . "sorted") (:end . 57) (:start . 51)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s3.65) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100846@unknown@formal@none@1@S@Artifactual motifs, whose significance can be accounted for by higher scoring motifs that they overlap, are identified and removed (for details, see Additional file 1, section S1).@(((:tag . "JJ") (:stem . "artifactual") (:form . "Artifactual") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 38)\n  (:start . 26) (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "account") (:form . "accounted") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 69) (:start . 63)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 84)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 143)\n  (:start . 136) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 159)\n  (:start . 149) (:id . 68))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . "NN") (:stem . "s1") (:form . "S1") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s3.66) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100847@unknown@formal@none@1@S@Flow diagram for SCOPE@(((:tag . "NNP") (:stem . "Flow") (:form . "Flow") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "diagram") (:form . "diagram") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 22) (:start . 17)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s3.67) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100848@unknown@formal@none@1@S@Flow diagram for SCOPE.@(((:tag . "NNP") (:stem . "Flow") (:form . "Flow") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "diagram") (:form . "diagram") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 23) (:start . 22)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s3.68) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100850@unknown@formal@none@1@S@For yeast (whose upstream regions are standardized to 800 bp), BEAM and PRISM use the overrepresentation-KS objective function (so/ks), while SPACER's slower running time requires the simpler overrepresentation objective function (so).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "standardize") (:form . "standardized") (:end . 50)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "800") (:form . "800") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "overrepresentation-ks")\n  (:form . "overrepresentation-KS") (:end . 107) (:start . 86) (:id . 60))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 126)\n  (:start . 118) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "so/k") (:form . "so/ks") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 141)\n  (:start . 136) (:id . 67))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 148)\n  (:start . 142) (:id . 68))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "JJR") (:stem . "slow") (:form . "slower") (:end . 157)\n  (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "running") (:form . "running") (:end . 165)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 179)\n  (:start . 171) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 74))\n ((:tag . "JJR") (:stem . "simple") (:form . "simpler") (:end . 191)\n  (:start . 184) (:id . 75))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 210) (:start . 192) (:id . 76))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 220)\n  (:start . 211) (:id . 77))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 229)\n  (:start . 221) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 231) (:start . 230)\n  (:id . 79))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 233) (:start . 231)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s3.70) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100851@unknown@formal@none@1@S@The top 5 motifs from SPACER are rescored using the combined objective function.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 16)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "rescore") (:form . "rescored") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.71) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100852@unknown@formal@none@1@S@For bacteria and Drosophila, upstream regions are defined to be the intergenic region upstream of each gene; thus, the KS objective function is not used.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intergenic") (:form . "intergenic") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 131)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 140)\n  (:start . 132) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x3.72.1) (:span 144 147)))\n (:nscopes ((:id . :x3.72.1) (:span 115 152)))\n (:identifiers (:sid . :s3.72) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100853@unknown@formal@none@1@S@The results of each program are sorted by Sig and lower scoring motifs that substantially overlap higher scoring motifs are removed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "sort") (:form . "sorted") (:end . 38) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "substantially") (:form . "substantially")\n  (:end . 89) (:start . 76) (:id . 56))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 119)\n  (:start . 113) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.73) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100854@unknown@formal@none@1@S@The filtered lists of motifs from the three programs are finally merged by Sig score.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "list") (:form . "lists") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "finally") (:form . "finally") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "VBN") (:stem . "merge") (:form . "merged") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.74) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100855@unknown@formal@none@1@S@Repetitive motifs are identified and removed during all stages.@(((:tag . "JJ") (:stem . "repetitive") (:form . "Repetitive") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 17)\n  (:start . 11) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s3.75) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100856@unknown@formal@none@1@S@Each of SCOPE's three component algorithms seeks to maximize the same objective function over a different class of motifs.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "VBZ") (:stem . "seek") (:form . "seeks") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "maximize") (:form . "maximize") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.76) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100857@unknown@formal@none@1@S@Let M be a random variable over the full space of IUPAC words.@(((:tag . "NN") (:stem . "let") (:form . "Let") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 17)\n  (:start . 11) (:id . 46))\n ((:tag . "NN") (:stem . "variable") (:form . "variable") (:end . 26)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 46) (:start . 41)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "word") (:form . "words") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.77) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100858@unknown@formal@none@1@S@The statistical significance p(M = m) of a particular word m is determined by the distribution of M over the entire space of upstream sequences in the given species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "NNP") (:stem . "p(M") (:form . "p(M") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "word") (:form . "word") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 94)\n  (:start . 82) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 104) (:start . 100)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 133)\n  (:start . 125) (:id . 66))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 156)\n  (:start . 151) (:id . 70))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 164)\n  (:start . 157) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s3.78) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100860@unknown@formal@none@1@S@All values of M are not, however, equally likely a priori.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 48))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 32)\n  (:start . 25) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 50))\n ((:tag . "RB") (:stem . "equally") (:form . "equally") (:end . 41)\n  (:start . 34) (:id . 51))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 48)\n  (:start . 42) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "priori") (:form . "priori") (:end . 57)\n  (:start . 51) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x3.80.2) (:span 42 48)))\n (:ncues ((:id . :x3.80.1) (:span 20 23)))\n (:hscopes ((:id . :x3.80.2) (:span 0 57)))\n (:nscopes ((:id . :x3.80.1) (:span 0 57)))\n (:identifiers (:sid . :s3.80) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100861@unknown@formal@none@1@S@For example, it is quite likely that there exists an extremely long sequence that is entirely unique to U.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 31)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 42) (:start . 37)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 62)\n  (:start . 53) (:id . 53))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "RB") (:stem . "entirely") (:form . "entirely") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x3.81.1) (:span 25 31)))\n (:hscopes ((:id . :x3.81.1) (:span 25 105)))\n (:identifiers (:sid . :s3.81) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100862@unknown@formal@none@1@S@Such a unique sequence would appear to be highly significant, until we consider that we have in effect searched all possible sequences until we found one that is unique.@(((:tag . "PDT") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 6) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "appear") (:form . "appear") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "consider") (:form . "consider") (:end . 79)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "VBD") (:stem . "search") (:form . "searched") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 168)\n  (:start . 162) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x3.82.1) (:span 116 124))\n  ((:id . :x3.82.2) (:span 23 28 29 35)))\n (:hscopes ((:id . :x3.82.1) (:span 116 134)) ((:id . :x3.82.2) (:span 0 60)))\n (:identifiers (:sid . :s3.82) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100863@unknown@formal@none@1@S@To correct for this multiple hypothesis testing problem, van Helden et al. 14 proposed using a Bonferroni correction, in which p(M = m) is penalized by the number of motifs N of length |m|:@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "correct") (:form . "correct") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "van") (:form . "van") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Helden") (:form . "Helden") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 86)\n  (:start . 78) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Bonferroni") (:form . "Bonferroni") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "NNP") (:stem . "p(M") (:form . "p(M") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "penalize") (:form . "penalized") (:end . 148)\n  (:start . 139) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 71))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 162)\n  (:start . 156) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 172)\n  (:start . 166) (:id . 74))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 174) (:start . 173)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 76))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 184)\n  (:start . 178) (:id . 77))\n ((:tag . "NN") (:stem . "|m|") (:form . "|m|") (:end . 188) (:start . 185)\n  (:id . 78))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 189) (:start . 188)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s3.83) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100864@unknown@formal@none@1@S@Sig = -log(p(M = m)·N).@(((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "-log(p(M") (:form . "-log(p(M") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "m)·N") (:form . "m)·N") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 23) (:start . 22)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s3.84) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100865@unknown@formal@none@1@S@Thus, if m = "ACGT", N = 44.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 12) (:start . 11)\n  (:id . 46))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 14) (:start . 13)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ACGT") (:form . "ACGT") (:end . 18) (:start . 14)\n  (:id . 48))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 19) (:start . 18)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 22) (:start . 21)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 24) (:start . 23)\n  (:id . 52))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 27) (:start . 25)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 28) (:start . 27)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.85) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100866@unknown@formal@none@1@S@We employed this same definition of Sig for BEAM, our algorithm that searches for non-degenerate motifs 10.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "employ") (:form . "employed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 77)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "non-degenerate") (:form . "non-degenerate")\n  (:end . 96) (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.86) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100867@unknown@formal@none@1@S@Defining N for degenerate or bipartite motifs raises a significant conceptual challenge.@(((:tag . "VBG") (:stem . "define") (:form . "Defining") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "conceptual") (:form . "conceptual") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "challenge") (:form . "challenge") (:end . 87)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.87) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100868@unknown@formal@none@1@S@Van Helden et al. 14 chose to use the same definition, but limited their search to a small number of degenerate bases.@(((:tag . "NNP") (:stem . "Van") (:form . "Van") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Helden") (:form . "Helden") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "choose") (:form . "chose") (:end . 26)\n  (:start . 21) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VB") (:stem . "use") (:form . "use") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 53)\n  (:start . 43) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "limit") (:form . "limited") (:end . 66)\n  (:start . 59) (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 72)\n  (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 79)\n  (:start . 73) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 97)\n  (:start . 91) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "degenerate") (:form . "degenerate") (:end . 111)\n  (:start . 101) (:id . 63))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 117)\n  (:start . 112) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s3.88) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100870@unknown@formal@none@1@S@By this logic, ""ACGT"" will not be penalized differently from ""ACNNNNGT"", as both have the same number of bases that contribute any information to protein-DNA binding.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "logic") (:form . "logic") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "”ACGT") (:form . "”ACGT") (:end . 21) (:start . 16)\n  (:id . 47))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 22) (:start . 21)\n  (:id . 48))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 23) (:start . 22)\n  (:id . 49))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 28) (:start . 24)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "penalize") (:form . "penalized") (:end . 45)\n  (:start . 36) (:id . 53))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 57)\n  (:start . 46) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 55))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "”ACNNNNGT") (:form . "”ACNNNNGT") (:end . 73)\n  (:start . 64) (:id . 57))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 74) (:start . 73)\n  (:id . 58))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 75) (:start . 74)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 79) (:start . 77)\n  (:id . 61))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 84) (:start . 80)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 89) (:start . 85)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 98) (:start . 94)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 105)\n  (:start . 99) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 114)\n  (:start . 109) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "contribute") (:form . "contribute") (:end . 130)\n  (:start . 120) (:id . 70))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 134) (:start . 131)\n  (:id . 71))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 146)\n  (:start . 135) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "protein-dna") (:form . "protein-DNA") (:end . 161)\n  (:start . 150) (:id . 74))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 169)\n  (:start . 162) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x3.90.1) (:span 29 32)))\n (:nscopes ((:id . :x3.90.1) (:span 16 74)))\n (:identifiers (:sid . :s3.90) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100871@unknown@formal@none@1@S@Building on this intuition, one can argue that the characters ""A"" and ""not-A"" (IUPAC character ""B")" are roughly equivalent, while ""A or G"" (IUPAC character ""R")" is different from ""A"" as there are six ways to define a combination of two bases, while only four ways to define a combination of one base or three bases.@(((:tag . "NNP") (:stem . "Building") (:form . "Building") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "intuition") (:form . "intuition") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "one") (:form . "one") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VB") (:stem . "argue") (:form . "argue") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "character") (:form . "characters") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "”A") (:form . "”A") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 73) (:start . 72)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "”not-A") (:form . "”not-A") (:end . 79)\n  (:start . 73) (:id . 59))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 80) (:start . 79)\n  (:id . 60))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 81) (:start . 80)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 88) (:start . 83)\n  (:id . 63))\n ((:tag . "NN") (:stem . "character") (:form . "character") (:end . 98)\n  (:start . 89) (:id . 64))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 100) (:start . 99)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "”B") (:form . "”B") (:end . 102) (:start . 100)\n  (:id . 66))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 103) (:start . 102)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 68))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 105) (:start . 104)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 70))\n ((:tag . "RB") (:stem . "roughly") (:form . "roughly") (:end . 117)\n  (:start . 110) (:id . 71))\n ((:tag . "JJ") (:stem . "equivalent") (:form . "equivalent") (:end . 128)\n  (:start . 118) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 73))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 135)\n  (:start . 130) (:id . 74))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 137) (:start . 136)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "”A") (:form . "”A") (:end . 139) (:start . 137)\n  (:id . 76))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 142) (:start . 140)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 144) (:start . 143)\n  (:id . 78))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 145) (:start . 144)\n  (:id . 79))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 146) (:start . 145)\n  (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 153)\n  (:start . 148) (:id . 82))\n ((:tag . "NN") (:stem . "character") (:form . "character") (:end . 163)\n  (:start . 154) (:id . 83))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 165) (:start . 164)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "”R") (:form . "”R") (:end . 167) (:start . 165)\n  (:id . 85))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 168) (:start . 167)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 87))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 170) (:start . 169)\n  (:id . 88))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 173) (:start . 171)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 183)\n  (:start . 174) (:id . 90))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 188) (:start . 184)\n  (:id . 91))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 190) (:start . 189)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "”A") (:form . "”A") (:end . 192) (:start . 190)\n  (:id . 93))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 193) (:start . 192)\n  (:id . 94))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 194) (:start . 193)\n  (:id . 95))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 197) (:start . 195)\n  (:id . 96))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 203)\n  (:start . 198) (:id . 97))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 207) (:start . 204)\n  (:id . 98))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 211) (:start . 208)\n  (:id . 99))\n ((:tag . "NNS") (:stem . "way") (:form . "ways") (:end . 216) (:start . 212)\n  (:id . 100))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 101))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 226)\n  (:start . 220) (:id . 102))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 228) (:start . 227)\n  (:id . 103))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 240)\n  (:start . 229) (:id . 104))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 105))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 247) (:start . 244)\n  (:id . 106))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 253)\n  (:start . 248) (:id . 107))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 254) (:start . 253)\n  (:id . 108))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 260)\n  (:start . 255) (:id . 109))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 265) (:start . 261)\n  (:id . 110))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 270) (:start . 266)\n  (:id . 111))\n ((:tag . "NNS") (:stem . "way") (:form . "ways") (:end . 275) (:start . 271)\n  (:id . 112))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 278) (:start . 276)\n  (:id . 113))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 285)\n  (:start . 279) (:id . 114))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 287) (:start . 286)\n  (:id . 115))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 299)\n  (:start . 288) (:id . 116))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 302) (:start . 300)\n  (:id . 117))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 306) (:start . 303)\n  (:id . 118))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 311) (:start . 307)\n  (:id . 119))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 314) (:start . 312)\n  (:id . 120))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 320)\n  (:start . 315) (:id . 121))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 326)\n  (:start . 321) (:id . 122))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 327) (:start . 326)\n  (:id . 123)))@@@1@82@((:hcues ((:id . :x3.91.1) (:span 32 35)))\n (:hscopes ((:id . :x3.91.1) (:span 32 193)))\n (:identifiers (:sid . :s3.91) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100872@unknown@formal@none@1@S@For motif m = m1m2...mn, we can therefore define N = ∏ Choose(4, |mi|), where |mi| is the number of DNA bases covered by the IUPAC character mi.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "m1m2") (:form . "m1m2") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . ":") (:stem . "…") (:form . "…") (:end . 18) (:start . 18)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mn") (:form . "mn") (:end . 23) (:start . 21)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 31) (:start . 28)\n  (:id . 51))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 41)\n  (:start . 32) (:id . 52))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 48)\n  (:start . 42) (:id . 53))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 52) (:start . 51)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "∏") (:form . "∏") (:end . 54) (:start . 53)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Choose(4") (:form . "Choose(4") (:end . 63)\n  (:start . 55) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "|mi|") (:form . "|mi|") (:end . 69) (:start . 65)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 61))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 77) (:start . 72)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "|mi|") (:form . "|mi|") (:end . 82) (:start . 78)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 96)\n  (:start . 90) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 103) (:start . 100)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 109)\n  (:start . 104) (:id . 69))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 117)\n  (:start . 110) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 130)\n  (:start . 125) (:id . 73))\n ((:tag . "NN") (:stem . "character") (:form . "character") (:end . 140)\n  (:start . 131) (:id . 74))\n ((:tag . "NN") (:stem . "mi") (:form . "mi") (:end . 143) (:start . 141)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s3.92) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100873@unknown@formal@none@1@S@In the case were both orientations of the motif are considered, this number is adjusted to account for palindromes.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "orientation") (:form . "orientations") (:end . 34)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "adjust") (:form . "adjusted") (:end . 87)\n  (:start . 79) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 98)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "palindrome") (:form . "palindromes") (:end . 114)\n  (:start . 103) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.93) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100874@unknown@formal@none@1@S@The resulting Sig score thus penalizes motifs based on their length and degeneracy, enabling fair comparisons to be made between different motif classes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "penalize") (:form . "penalizes") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 60)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "degeneracy") (:form . "degeneracy") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "enable") (:form . "enabling") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "JJ") (:stem . "fair") (:form . "fair") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 109)\n  (:start . 98) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 128)\n  (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 144)\n  (:start . 139) (:id . 64))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 152)\n  (:start . 145) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.94) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100875@unknown@formal@none@1@S@Testing@(((:tag . "NNP") (:stem . "Testing") (:form . "Testing") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.95) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5100876@unknown@formal@none@1@S@Evaluation of objective functions used by SCOPE@(((:tag . "NN") (:stem . "evaluation") (:form . "Evaluation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 47) (:start . 42)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s3.96) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100877@unknown@formal@none@1@S@Each component algorithm in SCOPE efficiently searches its restricted search space, keeping SCOPE's runtime low (average runtime on our datasets were about one minute).@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "search") (:form . "searches") (:end . 54)\n  (:start . 46) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 76)\n  (:start . 70) (:id . 51))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "keep") (:form . "keeping") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "runtime") (:form . "runtime") (:end . 107)\n  (:start . 100) (:id . 57))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 120)\n  (:start . 113) (:id . 60))\n ((:tag . "NN") (:stem . "runtime") (:form . "runtime") (:end . 128)\n  (:start . 121) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 144)\n  (:start . 136) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 155)\n  (:start . 150) (:id . 66))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NN") (:stem . "minute") (:form . "minute") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s3.97) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100878@unknown@formal@none@1@S@This efficiency allowed us to explore several objective functions for scoring the statistical significance p(M = m) of motifs.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "efficiency") (:form . "efficiency") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 23)\n  (:start . 16) (:id . 44))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 93)\n  (:start . 82) (:id . 54))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 106)\n  (:start . 94) (:id . 55))\n ((:tag . "NNP") (:stem . "p(M") (:form . "p(M") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 112) (:start . 111)\n  (:id . 57))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 114) (:start . 113)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.98) (:did . :1471-2105-8-249) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5100880@unknown@formal@none@1@S@For precise definitions, see Methods.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "definition") (:form . "definitions") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Methods") (:form . "Methods") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 37) (:start . 36)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s3.100) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100881@unknown@formal@none@1@S@To establish which objective function (or combination of functions) was most suitable, we tested each objective function independently of SCOPE, using a subset of the S. cerevisiae dataset.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "establish") (:form . "establish") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "suitable") (:form . "suitable") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 96) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 111)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 120)\n  (:start . 112) (:id . 61))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 134) (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 150) (:start . 145)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 159)\n  (:start . 153) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 70))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 180)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 188)\n  (:start . 181) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s3.101) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100882@unknown@formal@none@1@S@The measure used to assess the biological relevance of a motif was accuracy, a measure of the nucleotide level overlap between a motif and the known binding sites (for details see Methods).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 104)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 134)\n  (:start . 129) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 148)\n  (:start . 143) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 156)\n  (:start . 149) (:id . 69))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 167) (:start . 164)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 175)\n  (:start . 168) (:id . 73))\n ((:tag . "VBP") (:stem . "see") (:form . "see") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Method") (:form . "Methods") (:end . 187)\n  (:start . 180) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s3.102) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100883@unknown@formal@none@1@S@From each regulon from the SCPD database 15 we selected ten six-mers at random from the upstream sequences and ten six-mers at random from the collection of known binding sites for that regulon.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SCPD") (:form . "SCPD") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "select") (:form . "selected") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "six-mer") (:form . "six-mers") (:end . 68)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "random") (:form . "random") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "six-mer") (:form . "six-mers") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "random") (:form . "random") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "collection") (:form . "collection") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 170)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 180) (:start . 177)\n  (:id . 72))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 193)\n  (:start . 186) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s3.103) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100884@unknown@formal@none@1@S@For each of these sampled six-mers, we calculated accuracy with respect to the known binding sites.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "sample") (:form . "sampled") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "six-mer") (:form . "six-mers") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "calculate") (:form . "calculated") (:end . 49)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 98) (:start . 93)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.104) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100885@unknown@formal@none@1@S@We also calculated the Sig score for each six-mer, using four objective functions (KS, overrepresentation, coverage and combined KS-overrepresentation).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "calculate") (:form . "calculated") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "six-mer") (:form . "six-mer") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 105) (:start . 87) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 115)\n  (:start . 107) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "ks-overrepresentation")\n  (:form . "KS-overrepresentation") (:end . 150) (:start . 129) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.105) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100886@unknown@formal@none@1@S@We then plotted Sig versus accuracy for each objective function, to determine which objective functions correlated most strongly with biological relevance (Figure 2).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "plot") (:form . "plotted") (:end . 15) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "determine") (:form . "determine") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "objective") (:form . "objective") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 103)\n  (:start . 94) (:id . 57))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 144)\n  (:start . 134) (:id . 62))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 154)\n  (:start . 145) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 156) (:start . 155)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 162)\n  (:start . 156) (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s3.106) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100887@unknown@formal@none@1@S@Correlation between accuracy and Sig scores@(((:tag . "NN") (:stem . "correlation") (:form . "Correlation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sig") (:form . "Sig") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 43)\n  (:start . 37) (:id . 47)))@@@1@6@((:identifiers (:sid . :s3.107) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100888@unknown@formal@none@1@S@Correlation between accuracy and Sig scores.@(((:tag . "NN") (:stem . "correlation") (:form . "Correlation") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 28)\n  (:start . 20) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sig") (:form . "Sig") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s3.108) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100890@unknown@formal@none@1@S@The 6-mers were randomly sampled from both the upstream regions and the known binding sites to ensure coverage or a wide range of accuracy.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "6-mer") (:form . "6-mers") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "sample") (:form . "sampled") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.110) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100891@unknown@formal@none@1@S@The x-axis plots the Bonferroni-corrected and log2 transformed Sig score for each metric.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "plot") (:form . "plots") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "bonferroni-corrected")\n  (:form . "Bonferroni-corrected") (:end . 41) (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NN") (:stem . "log2") (:form . "log2") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "transform") (:form . "transformed") (:end . 62)\n  (:start . 51) (:id . 49))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "metric") (:form . "metric") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.111) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100892@unknown@formal@none@1@S@The red lines indicate the 95th Sig percentile.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "95th") (:form . "95th") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "percentile") (:form . "percentile") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s3.112) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100893@unknown@formal@none@1@S@These plots demonstrate that overrepresentation is a closer approximation to biological relevance than coverage or KS alone.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "plot") (:form . "plots") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 47) (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "close") (:form . "closer") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "approximation") (:form . "approximation")\n  (:end . 73) (:start . 60) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 87)\n  (:start . 77) (:id . 52))\n ((:tag . "NN") (:stem . "relevance") (:form . "relevance") (:end . 97)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 102) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 111)\n  (:start . 103) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 114) (:start . 112)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ks") (:form . "KS") (:end . 117) (:start . 115)\n  (:id . 57))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.113) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100894@unknown@formal@none@1@S@Adding KS to overrepresentation modestly improved the correlation by 13% (as compared to overrepresentation alone) to R2 = 0.28.@(((:tag . "VBG") (:stem . "add") (:form . "Adding") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ks") (:form . "KS") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 31) (:start . 13) (:id . 45))\n ((:tag . "RB") (:stem . "modestly") (:form . "modestly") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBD") (:stem . "improve") (:form . "improved") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 65)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 50))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 107) (:start . 89) (:id . 57))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "r2") (:form . "R2") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.28") (:form . "0.28") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.114) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100895@unknown@formal@none@1@S@To assess the degree of class separation achieved by the two objective functions, we ranked the sampled six-mers by Sig score, and calculated the percentage of motifs with high Sig scores (in the 95th percentile and above) that possessed a reasonable degree of overlap with the known binding sites (accuracy ≥ 0.10).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "separation") (:form . "separation") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "rank") (:form . "ranked") (:end . 91) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "sample") (:form . "sampled") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NNS") (:stem . "six-mer") (:form . "six-mers") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "calculate") (:form . "calculated") (:end . 141)\n  (:start . 131) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 156)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 171) (:start . 167)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 176) (:start . 172)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 180) (:start . 177)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 187)\n  (:start . 181) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "95th") (:form . "95th") (:end . 200) (:start . 196)\n  (:id . 78))\n ((:tag . "NN") (:stem . "percentile") (:form . "percentile") (:end . 211)\n  (:start . 201) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 80))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 221)\n  (:start . 216) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 82))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 227) (:start . 223)\n  (:id . 83))\n ((:tag . "VBD") (:stem . "possess") (:form . "possessed") (:end . 237)\n  (:start . 228) (:id . 84))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 239) (:start . 238)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "reasonable") (:form . "reasonable") (:end . 250)\n  (:start . 240) (:id . 86))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 257)\n  (:start . 251) (:id . 87))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 260) (:start . 258)\n  (:id . 88))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 268)\n  (:start . 261) (:id . 89))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 273) (:start . 269)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 277) (:start . 274)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 283)\n  (:start . 278) (:id . 92))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 291)\n  (:start . 284) (:id . 93))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 297)\n  (:start . 292) (:id . 94))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 299) (:start . 298)\n  (:id . 95))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 307)\n  (:start . 299) (:id . 96))\n ((:tag . "NN") (:stem . "≥") (:form . "≥") (:end . 309) (:start . 308)\n  (:id . 97))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 314) (:start . 310)\n  (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 315) (:start . 314)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 316) (:start . 315)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s3.115) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100896@unknown@formal@none@1@S@By the overrepresentation measure, 74.4% of high scoring motifs had accuracy = 0.10, while 79.1% of high scoring motifs by KS-overrepresentation had accuracy ≥ 0.10.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 25) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 46))\n ((:tag . "CD") (:stem . "74.4") (:form . "74.4") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "CD") (:stem . "79.1") (:form . "79.1") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 112)\n  (:start . 105) (:id . 63))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 119)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "KS-overrepresentation")\n  (:form . "KS-overrepresentation") (:end . 144) (:start . 123) (:id . 66))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "NNP") (:stem . "≥") (:form . "≥") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s3.116) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100897@unknown@formal@none@1@S@This analysis suggests that more complex objective functions may provide a better estimate of biological significance than the overrepresentation objective functions commonly used.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 72)\n  (:start . 65) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 81) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 117)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 122) (:start . 118)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 145) (:start . 127) (:id . 60))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 155)\n  (:start . 146) (:id . 61))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 165)\n  (:start . 156) (:id . 62))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 174)\n  (:start . 166) (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 179) (:start . 175)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x3.117.1) (:span 61 64)) ((:id . :x3.117.2) (:span 14 22)))\n (:hscopes ((:id . :x3.117.1) (:span 61 179))\n  ((:id . :x3.117.2) (:span 14 179)))\n (:identifiers (:sid . :s3.117) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100898@unknown@formal@none@1@S@We thus chose to run SCOPE using the overrepresentation-KS combined objective function on the S. cerevisiae dataset, in which the upstream regions are of fixed length.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "choose") (:form . "chose") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "run") (:form . "run") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "overrepresentation-ks")\n  (:form . "overrepresentation-KS") (:end . 58) (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 77)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 115)\n  (:start . 108) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 146)\n  (:start . 139) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "fix") (:form . "fixed") (:end . 159) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.118) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100900@unknown@formal@none@1@S@Because identifying the genomic positions of highly degenerate bipartite motifs is prohibitively slow, initial rankings of motifs for SPACER were computed using the overrepresentation objective function, and the overrepresentation-KS objective function was used only to produce the final ordering and scores.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 51)\n  (:start . 45) (:id . 48))\n ((:tag . "VBP") (:stem . "degenerate") (:form . "degenerate") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 79)\n  (:start . 73) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 52))\n ((:tag . "RB") (:stem . "prohibitively") (:form . "prohibitively")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 101) (:start . 97)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "NNS") (:stem . "ranking") (:form . "rankings") (:end . 119)\n  (:start . 111) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 129)\n  (:start . 123) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 154)\n  (:start . 146) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 160) (:start . 155)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 183) (:start . 165) (:id . 66))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 193)\n  (:start . 184) (:id . 67))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 202)\n  (:start . 194) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 211) (:start . 208)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "overrepresentation-ks")\n  (:form . "overrepresentation-KS") (:end . 233) (:start . 212) (:id . 72))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 243)\n  (:start . 234) (:id . 73))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 252)\n  (:start . 244) (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 256) (:start . 253)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 261) (:start . 257)\n  (:id . 76))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 266) (:start . 262)\n  (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 269) (:start . 267)\n  (:id . 78))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 277)\n  (:start . 270) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 281) (:start . 278)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 287)\n  (:start . 282) (:id . 81))\n ((:tag . "NN") (:stem . "ordering") (:form . "ordering") (:end . 296)\n  (:start . 288) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 300) (:start . 297)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 307)\n  (:start . 301) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 308) (:start . 307)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s3.120) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100901@unknown@formal@none@1@S@Although the KS objective function is computationally expensive (linear in the frequency of the motif in the genome), the SCOPE algorithms all aggressively limit the search space, thereby making the use of this objective function – and exploration of other complex objective functions – possible.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "computationally") (:form . "computationally")\n  (:end . 53) (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "expensive") (:form . "expensive") (:end . 63)\n  (:start . 54) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "VBZ") (:stem . "algorithm") (:form . "algorithms") (:end . 138)\n  (:start . 128) (:id . 65))\n ((:tag . "RB") (:stem . "all") (:form . "all") (:end . 142) (:start . 139)\n  (:id . 66))\n ((:tag . "RB") (:stem . "aggressively") (:form . "aggressively") (:end . 155)\n  (:start . 143) (:id . 67))\n ((:tag . "VBP") (:stem . "limit") (:form . "limit") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 172)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 72))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 187)\n  (:start . 180) (:id . 73))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 194)\n  (:start . 188) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 75))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 202) (:start . 199)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 77))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 210) (:start . 206)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 220)\n  (:start . 211) (:id . 79))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . "NN") (:stem . "–") (:form . "–") (:end . 231) (:start . 230)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 235) (:start . 232)\n  (:id . 82))\n ((:tag . "NN") (:stem . "exploration") (:form . "exploration") (:end . 247)\n  (:start . 236) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 250) (:start . 248)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 256)\n  (:start . 251) (:id . 85))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 264)\n  (:start . 257) (:id . 86))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 274)\n  (:start . 265) (:id . 87))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 284)\n  (:start . 275) (:id . 88))\n ((:tag . "VBP") (:stem . "–") (:form . "–") (:end . 286) (:start . 285)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 295)\n  (:start . 287) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x3.121.1) (:span 287 295)))\n (:hscopes ((:id . :x3.121.1) (:span 195 295)))\n (:identifiers (:sid . :s3.121) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100902@unknown@formal@none@1@S@The surprisingly low correlations between Sig and accuracy may indicate that the objective functions employed by motif finding programs are only a first approximation to biological significance.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "surprisingly") (:form . "surprisingly") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "correlation") (:form . "correlations") (:end . 33)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 41)\n  (:start . 34) (:id . 46))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 100)\n  (:start . 91) (:id . 55))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 109)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 118)\n  (:start . 113) (:id . 58))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 139) (:start . 136)\n  (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 146) (:start . 145)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 152)\n  (:start . 147) (:id . 64))\n ((:tag . "NN") (:stem . "approximation") (:form . "approximation")\n  (:end . 166) (:start . 153) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 180)\n  (:start . 170) (:id . 67))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 193)\n  (:start . 181) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x3.122.1) (:span 63 76)) ((:id . :x3.122.2) (:span 59 62)))\n (:hscopes ((:id . :x3.122.1) (:span 63 193))\n  ((:id . :x3.122.2) (:span 59 193)))\n (:identifiers (:sid . :s3.122) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100903@unknown@formal@none@1@S@Indeed, previous studies have reported little or no correlation between the significance measures of various motif finders and measures of accuracy 416.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 63)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 88)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 97)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "measure") (:form . "measures") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "CD") (:stem . "416") (:form . "416") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x3.123.1) (:span 49 51)))\n (:nscopes ((:id . :x3.123.1) (:span 49 63)))\n (:identifiers (:sid . :s3.123) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100904@unknown@formal@none@1@S@Further research into more biologically accurate objective functions may yield better performance for motif discovery algorithms.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "research") (:form . "research") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 39)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "accurate") (:form . "accurate") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 58)\n  (:start . 49) (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 68)\n  (:start . 59) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 72) (:start . 69)\n  (:id . 50))\n ((:tag . "VB") (:stem . "yield") (:form . "yield") (:end . 78) (:start . 73)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 85) (:start . 79)\n  (:id . 52))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 97)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 107)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 117)\n  (:start . 108) (:id . 56))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 128)\n  (:start . 118) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x3.124.1) (:span 69 72)))\n (:hscopes ((:id . :x3.124.1) (:span 69 128)))\n (:identifiers (:sid . :s3.124) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100905@unknown@formal@none@1@S@Evaluation of SCOPE performance and ensemble learning scheme@(((:tag . "NN") (:stem . "evaluation") (:form . "Evaluation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "ensemble") (:form . "ensemble") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "VBG") (:stem . "learn") (:form . "learning") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 60)\n  (:start . 54) (:id . 49)))@@@1@8@((:identifiers (:sid . :s3.125) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100906@unknown@formal@none@1@S@We first assessed the performance of the optimized SCOPE framework on synthetic datasets (for details, see Additional file 1, section S2).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "assess") (:form . "assessed") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "optimize") (:form . "optimized") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 66)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 101)\n  (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 117)\n  (:start . 107) (:id . 60))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s3.126) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100907@unknown@formal@none@1@S@SCOPE performed well on the synthetic datasets, correctly identifying 92% of planted motifs that are over-represented relative to background (those motifs with a Sig score of greater than 5; Figure 3).@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "RB") (:stem . "correctly") (:form . "correctly") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "CD") (:stem . "92") (:form . "92") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "plant") (:form . "planted") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "over-represented") (:form . "over-represented")\n  (:end . 117) (:start . 101) (:id . 59))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 126)\n  (:start . 118) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 154)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 187) (:start . 183)\n  (:id . 72))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 189) (:start . 188)\n  (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 197)\n  (:start . 191) (:id . 75))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 199) (:start . 198)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 200) (:start . 199)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s3.127) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100908@unknown@formal@none@1@S@Performance at different overrepresentation Sig values on synthetic data@(((:tag . "NNP") (:stem . "Performance") (:form . "Performance") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 24)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 43) (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "sig") (:form . "Sig") (:end . 47) (:start . 44)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 54)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 57) (:start . 55)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 67)\n  (:start . 58) (:id . 49))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 72) (:start . 68)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s3.128) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100910@unknown@formal@none@1@S@A motif was "found" if the top scoring motif returned by SCOPE overlapped the planted motif by at least 50%.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 18) (:start . 13)\n  (:id . 46))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 22) (:start . 20)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 30) (:start . 27)\n  (:id . 50))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 38)\n  (:start . 31) (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 44) (:start . 39)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "return") (:form . "returned") (:end . 53)\n  (:start . 45) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 62) (:start . 57)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "overlap") (:form . "overlapped") (:end . 73)\n  (:start . 63) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "plant") (:form . "planted") (:end . 85)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 103)\n  (:start . 98) (:id . 62))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 107) (:start . 106)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s3.130) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100911@unknown@formal@none@1@S@Different Sig values were achieved by varying the number of upstream regions, the number of motifs per upstream region, and the number of extraneous upstream regions without planted motifs.@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "vary") (:form . "varying") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 76)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 134)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 165)\n  (:start . 158) (:id . 69))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 173)\n  (:start . 166) (:id . 70))\n ((:tag . "VBN") (:stem . "plant") (:form . "planted") (:end . 181)\n  (:start . 174) (:id . 71))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 188)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x3.131.1) (:span 166 173)))\n (:nscopes ((:id . :x3.131.1) (:span 166 188)))\n (:identifiers (:sid . :s3.131) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100912@unknown@formal@none@1@S@A Sig value of 0 implies that one motif of that significance is expected by chance.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 24)\n  (:start . 17) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 39) (:start . 34)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 60)\n  (:start . 48) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s3.132) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100913@unknown@formal@none@1@S@While synthetic test sets are useful in algorithmic development and initial testing, the results of such tests must be taken with a grain of salt, as they are highly dependent on the model used to generate the test sets 6.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "useful") (:form . "useful") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "algorithmic") (:form . "algorithmic") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "initial") (:form . "initial") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "test") (:form . "tests") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "grain") (:form . "grain") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "salt") (:form . "salt") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 154) (:start . 150)\n  (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 165)\n  (:start . 159) (:id . 72))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 175)\n  (:start . 166) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 178) (:start . 176)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 75))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 188)\n  (:start . 183) (:id . 76))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 193) (:start . 189)\n  (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 196) (:start . 194)\n  (:id . 78))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 205)\n  (:start . 197) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 80))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 214) (:start . 210)\n  (:id . 81))\n ((:tag . "VBZ") (:stem . "set") (:form . "sets") (:end . 219) (:start . 215)\n  (:id . 82))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 221) (:start . 220)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s3.133) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100914@unknown@formal@none@1@S@We therefore tested SCOPE on an extensive array of regulons with known binding sites (for details of datasets, see Additional file 1, section S3).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 19) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "array") (:form . "array") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "s3") (:form . "S3") (:end . 144) (:start . 142)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s3.134) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100915@unknown@formal@none@1@S@We ran SCOPE on each regulon and, following the scoring methodology used by Sinha and Tompa 6, we computed the accuracy for each of the top three motifs reported by SCOPE against the known binding sites.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "run") (:form . "ran") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 43)\n  (:start . 34) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "methodology") (:form . "methodology") (:end . 67)\n  (:start . 56) (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Sinha") (:form . "Sinha") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Tompa") (:form . "Tompa") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 97) (:start . 95)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "compute") (:form . "computed") (:end . 106)\n  (:start . 98) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 145)\n  (:start . 140) (:id . 70))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 152)\n  (:start . 146) (:id . 71))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 161)\n  (:start . 153) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 170)\n  (:start . 165) (:id . 74))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 178)\n  (:start . 171) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 188)\n  (:start . 183) (:id . 77))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 196)\n  (:start . 189) (:id . 78))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 202)\n  (:start . 197) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s3.135) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100916@unknown@formal@none@1@S@The motifs reported by SCOPE overlap to a large extent with the published cis-regulatory elements (as discussed in Additional file 1, section S3, a difference of one base pair length between the reported motif and the published cis-regulatory element results in an expected accuracy of about 0.25).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 88) (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 125)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "s3") (:form . "S3") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 158)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 175) (:start . 171)\n  (:id . 73))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 182)\n  (:start . 176) (:id . 74))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 190)\n  (:start . 183) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 203)\n  (:start . 195) (:id . 77))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 209)\n  (:start . 204) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 213) (:start . 210)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 227)\n  (:start . 218) (:id . 81))\n ((:tag . "JJ") (:stem . "cis-regulatory") (:form . "cis-regulatory")\n  (:end . 242) (:start . 228) (:id . 82))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 250)\n  (:start . 243) (:id . 83))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 258)\n  (:start . 251) (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 261) (:start . 259)\n  (:id . 85))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 264) (:start . 262)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "expected") (:form . "expected") (:end . 273)\n  (:start . 265) (:id . 87))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 282)\n  (:start . 274) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 285) (:start . 283)\n  (:id . 89))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 291)\n  (:start . 286) (:id . 90))\n ((:tag . "CD") (:stem . "0.25") (:form . "0.25") (:end . 296) (:start . 292)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 297) (:start . 296)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 298) (:start . 297)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s3.136) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100917@unknown@formal@none@1@S@SCOPE was run on 78 regulons from S. cerevisiae, B. subtilis, E. coli and D. melanogaster.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "run") (:form . "run") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 47)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B.") (:form . "B.") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "subtilis") (:form . "subtilis") (:end . 60)\n  (:start . 52) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 69) (:start . 65)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 76) (:start . 74)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster") (:end . 89)\n  (:start . 77) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.137) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100918@unknown@formal@none@1@S@On these datasets, SCOPE's average accuracy was 0.28, 0.29, 0.16, and 0.08 respectively.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "0.28") (:form . "0.28") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0.29") (:form . "0.29") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 54))\n ((:tag . "CD") (:stem . "0.16") (:form . "0.16") (:end . 64) (:start . 60)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 57))\n ((:tag . "CD") (:stem . "0.08") (:form . "0.08") (:end . 74) (:start . 70)\n  (:id . 58))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 87)\n  (:start . 75) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.138) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100920@unknown@formal@none@1@S@Indeed, we found that SCOPE increased accuracy by 31–44% over BEAM, PRISM or SPACER alone.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "31–44") (:form . "31–44") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "spacer") (:form . "SPACER") (:end . 83)\n  (:start . 77) (:id . 58))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 89) (:start . 84)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.140) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100921@unknown@formal@none@1@S@This improvement was achieved by combining BEAM's high positive predictive value (PPV) with PRISM's high sensitivity (Figure 4).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "improvement") (:form . "improvement") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 116)\n  (:start . 105) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.141) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100922@unknown@formal@none@1@S@Sensitivity is defined here as the fraction of the known binding sites (at the nucleotide level) predicted by the motif finder, and PPV is defined as the fraction of nucleotides predicted by the motif finder that correspond to the known binding sites (see Methods for details).@(((:tag . "NN") (:stem . "sensitivity") (:form . "Sensitivity") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 126)\n  (:start . 120) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 146)\n  (:start . 139) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 149) (:start . 147)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 162)\n  (:start . 154) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 165) (:start . 163)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 177)\n  (:start . 166) (:id . 74))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 187)\n  (:start . 178) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 190) (:start . 188)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 77))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 200)\n  (:start . 195) (:id . 78))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 207)\n  (:start . 201) (:id . 79))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 212) (:start . 208)\n  (:id . 80))\n ((:tag . "VBP") (:stem . "correspond") (:form . "correspond") (:end . 223)\n  (:start . 213) (:id . 81))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 226) (:start . 224)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 236)\n  (:start . 231) (:id . 84))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 244)\n  (:start . 237) (:id . 85))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 250)\n  (:start . 245) (:id . 86))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 252) (:start . 251)\n  (:id . 87))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 255) (:start . 252)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 263)\n  (:start . 256) (:id . 89))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 267) (:start . 264)\n  (:id . 90))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 275)\n  (:start . 268) (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 276) (:start . 275)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 277) (:start . 276)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s3.142) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100923@unknown@formal@none@1@S@Summary results for performance comparisons between SCOPE and its component algorithms, on all regulons.@(((:tag . "JJ") (:stem . "summary") (:form . "Summary") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 43)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 51)\n  (:start . 44) (:id . 47))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 57) (:start . 52)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 75)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 86)\n  (:start . 76) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 94) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.143) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5100924@unknown@formal@none@1@S@A "Win" is a regulon for which a program had the highest accuracy and that accuracy was at least 0.10.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 3) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Win") (:form . "Win") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 7) (:start . 6)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 20)\n  (:start . 13) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 30) (:start . 25)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 51))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 40)\n  (:start . 33) (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 44) (:start . 41)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 54))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 56)\n  (:start . 49) (:id . 55))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 65)\n  (:start . 57) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 58))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 83)\n  (:start . 75) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 90) (:start . 88)\n  (:id . 61))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 96) (:start . 91)\n  (:id . 62))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 101) (:start . 97)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.144) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100925@unknown@formal@none@1@S@Programs in a two-way tie are credited with 0.5 wins each, so by construction, SCOPE can at best share a win with one of the other programs.@(((:tag . "NNS") (:stem . "program") (:form . "Programs") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "two-way") (:form . "two-way") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "tie") (:form . "tie") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "credit") (:form . "credited") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "construction") (:form . "construction") (:end . 77)\n  (:start . 65) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "share") (:form . "share") (:end . 102) (:start . 97)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "win") (:form . "win") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 113) (:start . 109)\n  (:id . 65))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 117) (:start . 114)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 130)\n  (:start . 125) (:id . 69))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 139)\n  (:start . 131) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s3.145) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100926@unknown@formal@none@1@S@A perfect winner-take-all ensemble method would have the same number of wins as all the component algorithms combined.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "perfect") (:form . "perfect") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "winner-take-all") (:form . "winner-take-all")\n  (:end . 25) (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 34)\n  (:start . 26) (:id . 45))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 41)\n  (:start . 35) (:id . 46))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 117)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x3.146.1) (:span 42 47)))\n (:hscopes ((:id . :x3.146.1) (:span 42 117)))\n (:identifiers (:sid . :s3.146) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100927@unknown@formal@none@1@S@A "clear win (loss)" is a regulon for which SCOPE's accuracy was at least 0.10 higher (lower) than the other program.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 3) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 8) (:start . 3)\n  (:id . 44))\n ((:tag . "NN") (:stem . "win") (:form . "win") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 18) (:start . 14)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 48))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 20) (:start . 19)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 33)\n  (:start . 26) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 43) (:start . 38)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 49) (:start . 44)\n  (:id . 55))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 51) (:start . 49)\n  (:id . 56))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 60)\n  (:start . 52) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 64) (:start . 61)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 67) (:start . 65)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 73) (:start . 68)\n  (:id . 60))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 78) (:start . 74)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 85) (:start . 79)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 63))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 92) (:start . 87)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 98) (:start . 94)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 108)\n  (:start . 103) (:id . 68))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 116)\n  (:start . 109) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s3.147) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100928@unknown@formal@none@1@S@The p-value reported for the paired t-test was Bonferroni-corrected to account for multiple (three) comparisons.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p-value") (:form . "p-value") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "paired") (:form . "paired") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "t-test") (:form . "t-test") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "bonferroni-correcte")\n  (:form . "Bonferroni-corrected") (:end . 67) (:start . 47) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 78)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 91)\n  (:start . 83) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 111)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.148) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100930@unknown@formal@none@1@S@Average and standard error of sensitivity and PPV for the component algorithms of SCOPE on all 78 regulons.@(((:tag . "JJ") (:stem . "average") (:form . "Average") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 67)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.150) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100931@unknown@formal@none@1@S@Bars represent standard error.@(((:tag . "NNS") (:stem . "bar") (:form . "Bars") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 30) (:start . 29)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s3.151) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100932@unknown@formal@none@1@S@An ensemble motif finder with a learning rule that is no better than random will provide an accuracy that is equal to the average of its three component algorithms.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 63) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "random") (:form . "random") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 142)\n  (:start . 137) (:id . 68))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 152)\n  (:start . 143) (:id . 69))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 163)\n  (:start . 153) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x3.152.1) (:span 54 56)))\n (:nscopes ((:id . :x3.152.1) (:span 54 75)))\n (:identifiers (:sid . :s3.152) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100933@unknown@formal@none@1@S@To provide a basis for evaluating the performance of SCOPE's learning rule, we constructed an ensemble learning method (referred to here as BASELINE) from the results of BEAM, PRISM and SPACER, by randomly selecting one of the accuracies from these three programs for each regulon.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "evaluate") (:form . "evaluating") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "construct") (:form . "constructed") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 111)\n  (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 118)\n  (:start . 112) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "BASELINE") (:form . "BASELINE") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 166)\n  (:start . 159) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 174) (:start . 170)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 74))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 181)\n  (:start . 176) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 192)\n  (:start . 186) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 196) (:start . 194)\n  (:id . 79))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 205)\n  (:start . 197) (:id . 80))\n ((:tag . "VBG") (:stem . "select") (:form . "selecting") (:end . 215)\n  (:start . 206) (:id . 81))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 219) (:start . 216)\n  (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 222) (:start . 220)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "accuracy") (:form . "accuracies") (:end . 237)\n  (:start . 227) (:id . 85))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 242) (:start . 238)\n  (:id . 86))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 248)\n  (:start . 243) (:id . 87))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 254)\n  (:start . 249) (:id . 88))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 263)\n  (:start . 255) (:id . 89))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 267) (:start . 264)\n  (:id . 90))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 272) (:start . 268)\n  (:id . 91))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 280)\n  (:start . 273) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 281) (:start . 280)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s3.153) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100934@unknown@formal@none@1@S@Over 120,000 trials, BASELINE's average performance on this dataset was 0.176 with a standard deviation of 0.013.@(((:tag . "IN") (:stem . "over") (:form . "Over") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "120,000") (:form . "120,000") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "trial") (:form . "trials") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BASELINE") (:form . "BASELINE") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "CD") (:stem . "0.176") (:form . "0.176") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "deviation") (:form . "deviation") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "CD") (:stem . "0.013") (:form . "0.013") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s3.154) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100935@unknown@formal@none@1@S@BASELINE's average score never exceeded that of SCOPE (p < 8.25 × 10-6).@(((:tag . "NN") (:stem . "baseline") (:form . "BASELINE") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "never") (:form . "never") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "exceed") (:form . "exceeded") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "CD") (:stem . "8.25") (:form . "8.25") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "CC") (:stem . "×") (:form . "×") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "CD") (:stem . "10-6") (:form . "10-6") (:end . 70) (:start . 66)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s3.155) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100936@unknown@formal@none@1@S@When compared to its component algorithms, SCOPE picked the highest accuracy motif in 66% of the cases (as opposed to 33% for a random selection between three algorithms).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "pick") (:form . "picked") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "CD") (:stem . "66") (:form . "66") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "oppose") (:form . "opposed") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 121) (:start . 120)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 134)\n  (:start . 128) (:id . 69))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 144)\n  (:start . 135) (:id . 70))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 152)\n  (:start . 145) (:id . 71))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 158)\n  (:start . 153) (:id . 72))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 169)\n  (:start . 159) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s3.156) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100937@unknown@formal@none@1@S@These results suggest that SCOPE's learning rule is highly effective, though it may certainly be improved further.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "certainly") (:form . "certainly") (:end . 93)\n  (:start . 84) (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x3.157.1) (:span 80 83)) ((:id . :x3.157.2) (:span 14 21)))\n (:hscopes ((:id . :x3.157.1) (:span 77 113))\n  ((:id . :x3.157.2) (:span 14 113)))\n (:identifiers (:sid . :s3.157) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100938@unknown@formal@none@1@S@Of course, SCOPE's learning rule is extremely simple, and more complex learning rules may allow SCOPE to approach its theoretical upper bound.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "VBG") (:stem . "learn") (:form . "learning") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "NNS") (:stem . "rule") (:form . "rules") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 101)\n  (:start . 96) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "VB") (:stem . "approach") (:form . "approach") (:end . 113)\n  (:start . 105) (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "theoretical") (:form . "theoretical") (:end . 129)\n  (:start . 118) (:id . 64))\n ((:tag . "JJ") (:stem . "upper") (:form . "upper") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "bound") (:form . "bound") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x3.158.1) (:span 86 89)))\n (:hscopes ((:id . :x3.158.1) (:span 86 141)))\n (:identifiers (:sid . :s3.158) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100940@unknown@formal@none@1@S@The training of a more complex learning rule must, however, be performed in a cross-validation framework, and the size of the available dataset of regulons will place a practical limit on the complexity of the learning rule that can be devised.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "training") (:form . "training") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 72)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cross-validation") (:form . "cross-validation")\n  (:end . 94) (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "framework") (:form . "framework") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 135)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 155)\n  (:start . 147) (:id . 69))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . "VB") (:stem . "place") (:form . "place") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "practical") (:form . "practical") (:end . 178)\n  (:start . 169) (:id . 73))\n ((:tag . "NN") (:stem . "limit") (:form . "limit") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 187) (:start . 185)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 76))\n ((:tag . "NN") (:stem . "complexity") (:form . "complexity") (:end . 202)\n  (:start . 192) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 79))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 218)\n  (:start . 210) (:id . 80))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 223) (:start . 219)\n  (:id . 81))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 228) (:start . 224)\n  (:id . 82))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 232) (:start . 229)\n  (:id . 83))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 235) (:start . 233)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "devise") (:form . "devised") (:end . 243)\n  (:start . 236) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s3.160) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100941@unknown@formal@none@1@S@Comparison with other motif finding programs@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 44)\n  (:start . 36) (:id . 47)))@@@1@6@((:identifiers (:sid . :s3.161) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100942@unknown@formal@none@1@S@To provide a frame of reference for SCOPE's performance, we ran ten other popular motif finders on these datasets (for details and references see Table 2).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "run") (:form . "ran") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "popular") (:form . "popular") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 98) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 104) (:start . 99)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 113)\n  (:start . 105) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 126)\n  (:start . 119) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "reference") (:form . "references") (:end . 141)\n  (:start . 131) (:id . 67))\n ((:tag . "VBP") (:stem . "see") (:form . "see") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 151)\n  (:start . 146) (:id . 69))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s3.162) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100943@unknown@formal@none@1@S@We ran all programs directly from their websites, leaving all parameters at their defaults.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "run") (:form . "ran") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 39)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "website") (:form . "websites") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "leave") (:form . "leaving") (:end . 57)\n  (:start . 50) (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 81)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "default") (:form . "defaults") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.163) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100944@unknown@formal@none@1@S@The only parameter that we specified (where available) was the species from which the background sequences were derived.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "specify") (:form . "specified") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 81) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 96)\n  (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 106)\n  (:start . 97) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.164) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100945@unknown@formal@none@1@S@Thus, the results of this performance comparison may be interpreted as a comparison against other motif finders when those motif finders are run using their default values.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 37)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "interpret") (:form . "interpreted") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 83)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 116) (:start . 112)\n  (:id . 60))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "run") (:form . "run") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 150) (:start . 145)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 156)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "default") (:form . "default") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 171)\n  (:start . 165) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x3.165.1) (:span 49 52)))\n (:hscopes ((:id . :x3.165.1) (:span 6 171)))\n (:identifiers (:sid . :s3.165) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100946@unknown@formal@none@1@S@Motif discovery algorithms used in the performance comparison.@(((:tag . "NN") (:stem . "motif") (:form . "Motif") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s3.166) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5100947@unknown@formal@none@1@S@Nuisance parameters are parameters that cannot be precisely defined without knowledge of the true binding sites (such as motif length, number of occurrences and orientation).@(((:tag . "NN") (:stem . "nuisance") (:form . "Nuisance") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "precisely") (:form . "precisely") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 85)\n  (:start . 76) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 97) (:start . 93)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 105)\n  (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 117) (:start . 113)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 60))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "occurrence") (:form . "occurrences") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 172)\n  (:start . 161) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x3.167.2) (:span 40 46)))\n (:ncues ((:id . :x3.167.1) (:span 68 75)))\n (:hscopes ((:id . :x3.167.2) (:span 40 173)))\n (:nscopes ((:id . :x3.167.1) (:span 68 173)))\n (:identifiers (:sid . :s3.167) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100948@unknown@formal@none@1@S@For MotifSampler and wConsensus, the lower part of the range indicates required parameters, while the upper part indicates the total number of parameters, including "power user" parameters that the program authors stress should typically be left as default.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MotifSampler") (:form . "MotifSampler") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "wConsensus") (:form . "wConsensus") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "upper") (:form . "upper") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 153)\n  (:start . 143) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 164)\n  (:start . 155) (:id . 68))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . "NN") (:stem . "user") (:form . "user") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 177) (:start . 176)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 188)\n  (:start . 178) (:id . 73))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 193) (:start . 189)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 205)\n  (:start . 198) (:id . 76))\n ((:tag . "NNS") (:stem . "author") (:form . "authors") (:end . 213)\n  (:start . 206) (:id . 77))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 220)\n  (:start . 214) (:id . 78))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 227)\n  (:start . 221) (:id . 79))\n ((:tag . "RB") (:stem . "typically") (:form . "typically") (:end . 237)\n  (:start . 228) (:id . 80))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 240) (:start . 238)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "leave") (:form . "left") (:end . 245)\n  (:start . 241) (:id . 82))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 248) (:start . 246)\n  (:id . 83))\n ((:tag . "NN") (:stem . "default") (:form . "default") (:end . 256)\n  (:start . 249) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x3.168.1) (:span 221 227)))\n (:hscopes ((:id . :x3.168.1) (:span 194 256)))\n (:identifiers (:sid . :s3.168) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100950@unknown@formal@none@1@S@SCOPE has no user-adjustable parameters, although its component algorithms do contain a number of internal parameters "("hyperparameters")" that govern their search over common nuisance parameters.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "user-adjustable") (:form . "user-adjustable")\n  (:end . 28) (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 74)\n  (:start . 64) (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 117)\n  (:start . 107) (:id . 58))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "”hyperparameters") (:form . "”hyperparameters")\n  (:end . 136) (:start . 120) (:id . 61))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 137) (:start . 136)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "govern") (:form . "govern") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 185)\n  (:start . 177) (:id . 71))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 196)\n  (:start . 186) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x3.170.1) (:span 10 12)))\n (:nscopes ((:id . :x3.170.1) (:span 10 39)))\n (:identifiers (:sid . :s3.170) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100951@unknown@formal@none@1@S@On synthetic datasets, we found SCOPE's component algorithms to be quite robust to the settings of these hyperparameters.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "robust") (:form . "robust") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "hyperparameter") (:form . "hyperparameters")\n  (:end . 120) (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.171) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100952@unknown@formal@none@1@S@We have therefore fixed those parameters to reasonable values and do not expose them to the user 101112.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "fix") (:form . "fixed") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "reasonable") (:form . "reasonable") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "expose") (:form . "expose") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "user") (:form . "user") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "101112") (:form . "101112") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x3.172.1) (:span 69 72)))\n (:nscopes ((:id . :x3.172.1) (:span 69 96)))\n (:identifiers (:sid . :s3.172) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100953@unknown@formal@none@1@S@This construction means that SCOPE can only run in a default configuration.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "construction") (:form . "construction") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "run") (:form . "run") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "default") (:form . "default") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "configuration") (:form . "configuration")\n  (:end . 74) (:start . 61) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.173) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100954@unknown@formal@none@1@S@We compared the motif finding programs using the criteria set forth in Sinha and Tompa, including average accuracy and the number of total wins (highest accuracy on a regulon, where that accuracy is at least 0.1) 6.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "set") (:form . "set") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "RB") (:stem . "forth") (:form . "forth") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Sinha") (:form . "Sinha") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Tompa") (:form . "Tompa") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 145) (:start . 144)\n  (:id . 67))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 152)\n  (:start . 145) (:id . 68))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 161)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 71))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 174)\n  (:start . 167) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 181)\n  (:start . 176) (:id . 74))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 186) (:start . 182)\n  (:id . 75))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 195)\n  (:start . 187) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 201) (:start . 199)\n  (:id . 78))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 207)\n  (:start . 202) (:id . 79))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 211) (:start . 208)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 81))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 214) (:start . 213)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s3.174) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100955@unknown@formal@none@1@S@On this dataset, SCOPE had the highest score by both criteria (Figure 5a).@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "criterion") (:form . "criteria") (:end . 61)\n  (:start . 53) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 69)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "5a") (:form . "5a") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s3.175) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100956@unknown@formal@none@1@S@The cumulative distribution of accuracy shows that SCOPE had the most high-scoring motifs at every level (Figure 5b).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "cumulative") (:form . "cumulative") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "high-scoring") (:form . "high-scoring") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 89)\n  (:start . 83) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 104) (:start . 99)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 112)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "5b") (:form . "5b") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.176) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100957@unknown@formal@none@1@S@When we looked at the number of clear head-to-head wins (such a win is taken to occur when the difference in accuracy between SCOPE and another motif finder is greater than 0.1 6), we found that SCOPE scored a clear majority (82%) of clear head-to-head wins (Figure 5c).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "look") (:form . "looked") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "head-to-head") (:form . "head-to-head") (:end . 50)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "win") (:form . "win") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 76) (:start . 71)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 85) (:start . 80)\n  (:id . 59))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 90) (:start . 86)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 105)\n  (:start . 95) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 117)\n  (:start . 109) (:id . 64))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 125)\n  (:start . 118) (:id . 65))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 131)\n  (:start . 126) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 67))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 143)\n  (:start . 136) (:id . 68))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 149)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 156)\n  (:start . 150) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 167)\n  (:start . 160) (:id . 72))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 172) (:start . 168)\n  (:id . 73))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 176) (:start . 173)\n  (:id . 74))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 178) (:start . 177)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 179) (:start . 178)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 77))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 183) (:start . 181)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 189)\n  (:start . 184) (:id . 79))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 194) (:start . 190)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 200)\n  (:start . 195) (:id . 81))\n ((:tag . "VBD") (:stem . "score") (:form . "scored") (:end . 207)\n  (:start . 201) (:id . 82))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 209) (:start . 208)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 215)\n  (:start . 210) (:id . 84))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 224)\n  (:start . 216) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 226) (:start . 225)\n  (:id . 86))\n ((:tag . "CD") (:stem . "82") (:form . "82") (:end . 228) (:start . 226)\n  (:id . 87))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 229) (:start . 228)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 230) (:start . 229)\n  (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 239)\n  (:start . 234) (:id . 91))\n ((:tag . "JJ") (:stem . "head-to-head") (:form . "head-to-head") (:end . 252)\n  (:start . 240) (:id . 92))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 257) (:start . 253)\n  (:id . 93))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 259) (:start . 258)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 265)\n  (:start . 259) (:id . 95))\n ((:tag . "NNP") (:stem . "5c") (:form . "5c") (:end . 268) (:start . 266)\n  (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 269) (:start . 268)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 98)))@@@1@57@((:identifiers (:sid . :s3.177) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100958@unknown@formal@none@1@S@The average accuracies of BEAM, PRISM and SPACER on this dataset were similar to those of the ten other programs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "accuracy") (:form . "accuracies") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "spacer") (:form . "SPACER") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 103) (:start . 98)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 112)\n  (:start . 104) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.178) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100960@unknown@formal@none@1@S@Performance comparisons.@(((:tag . "NNP") (:stem . "Performance") (:form . "Performance") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 24) (:start . 23)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s3.180) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100961@unknown@formal@none@1@S@(a) Mean and standard error of accuracy for each of 78 regulons.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "a") (:form . "a") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "mean") (:form . "Mean") (:end . 8) (:start . 4)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 21)\n  (:start . 13) (:id . 47))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 27) (:start . 22)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 39)\n  (:start . 31) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 48) (:start . 44)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 63)\n  (:start . 55) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s3.181) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100962@unknown@formal@none@1@S@(b) Cumulative distribution of accuracy for each program.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "b") (:form . "b") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "cumulative") (:form . "Cumulative") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 27)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s3.182) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100963@unknown@formal@none@1@S@(c) Fraction of regulons with a clear outcome (margin of difference in accuracy between two programs was greater than 0.10) won by SCOPE.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "fraction") (:form . "Fraction") (:end . 12)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "NN") (:stem . "outcome") (:form . "outcome") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 53)\n  (:start . 47) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 67)\n  (:start . 57) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 79)\n  (:start . 71) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 87)\n  (:start . 80) (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "CD") (:stem . "0.10") (:form . "0.10") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "win") (:form . "won") (:end . 127) (:start . 124)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 130) (:start . 128)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 136)\n  (:start . 131) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.183) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100964@unknown@formal@none@1@S@Program abbreviations and details in Table 2; performance details in tables S1 and S2 in Additional file 1.@(((:tag . "NN") (:stem . "program") (:form . "Program") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "table") (:form . "tables") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "s1") (:form . "S1") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s3.184) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100965@unknown@formal@none@1@S@A formal statistical analysis found that SCOPE's performance margin over the other motif finders run on this dataset was statistically significant at p < 10-5 (for details, see Additional file 1, section S3).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "formal") (:form . "formal") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "VBP") (:stem . "run") (:form . "run") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 134) (:start . 121) (:id . 62))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 146)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 149) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "p") (:form . "p") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 153) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "10-5") (:form . "10-5") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 171)\n  (:start . 164) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 187)\n  (:start . 177) (:id . 73))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 194) (:start . 193)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 76))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 203)\n  (:start . 196) (:id . 77))\n ((:tag . "NN") (:stem . "s3") (:form . "S3") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s3.185) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100966@unknown@formal@none@1@S@Corroborating the results of previously published performance comparisons \s14567\s, none of the other programs showed a statistically significant difference relative to the other nine.@(((:tag . "VBG") (:stem . "corroborate") (:form . "Corroborating") (:end . 13)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 61)\n  (:start . 50) (:id . 48))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 73)\n  (:start . 62) (:id . 49))\n ((:tag . "VBP") (:stem . "\s") (:form . "\s") (:end . 75) (:start . 74)\n  (:id . 50))\n ((:tag . "CD") (:stem . "14567") (:form . "14567") (:end . 80) (:start . 75)\n  (:id . 51))\n ((:tag . "NN") (:stem . "\s") (:form . "\s") (:end . 81) (:start . 80)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 132) (:start . 119) (:id . 61))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 144)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 155)\n  (:start . 145) (:id . 63))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 164)\n  (:start . 156) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 177)\n  (:start . 172) (:id . 67))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 182) (:start . 178)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x3.186.1) (:span 83 87)))\n (:nscopes ((:id . :x3.186.1) (:span 83 182)))\n (:identifiers (:sid . :s3.186) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100967@unknown@formal@none@1@S@Similarly, none of SCOPE's component algorithms outperformed the other ten programs on this dataset by a statistically significant margin.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 36)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "VBD") (:stem . "outperforme") (:form . "outperformed") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 118) (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 137)\n  (:start . 131) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x3.187.1) (:span 11 15)))\n (:nscopes ((:id . :x3.187.1) (:span 11 137)))\n (:identifiers (:sid . :s3.187) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100968@unknown@formal@none@1@S@SCOPE's high accuracy was a reflection of both high PPV and high sensitivity (Figure 6a; see Methods for a precise definition).@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "reflection") (:form . "reflection") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ppv") (:form . "PPV") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 76)\n  (:start . 65) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "6a") (:form . "6a") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 100)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 114)\n  (:start . 107) (:id . 64))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 125)\n  (:start . 115) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s3.188) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100970@unknown@formal@none@1@S@In contrast, none of the other motif finders that performed well by one criterion performed well by the other, as shown by the average ranks for each motif finder over both sensitivity and PPV (Figure 6b).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 36) (:start . 31)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "perform") (:form . "performed") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "criterion") (:form . "criterion") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 119)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 134)\n  (:start . 127) (:id . 67))\n ((:tag . "NNS") (:stem . "rank") (:form . "ranks") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 69))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 149) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 155)\n  (:start . 150) (:id . 71))\n ((:tag . "NN") (:stem . "finder") (:form . "finder") (:end . 162)\n  (:start . 156) (:id . 72))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 167) (:start . 163)\n  (:id . 73))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 172) (:start . 168)\n  (:id . 74))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 184)\n  (:start . 173) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 192) (:start . 189)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 194) (:start . 193)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 200)\n  (:start . 194) (:id . 79))\n ((:tag . "NN") (:stem . "6b") (:form . "6b") (:end . 203) (:start . 201)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x3.190.1) (:span 13 17)))\n (:nscopes ((:id . :x3.190.1) (:span 13 109)))\n (:identifiers (:sid . :s3.190) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100971@unknown@formal@none@1@S@(a) Average and standard error of sensitivity and PPV for each program on all 78 regulons@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "a") (:form . "a") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "average") (:form . "Average") (:end . 11)\n  (:start . 4) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 45)\n  (:start . 34) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 89)\n  (:start . 81) (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.191) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100972@unknown@formal@none@1@S@(a) Average and standard error of sensitivity and PPV for each program on all 78 regulons.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "a") (:form . "a") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "average") (:form . "Average") (:end . 11)\n  (:start . 4) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 30) (:start . 25)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 45)\n  (:start . 34) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 89)\n  (:start . 81) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.192) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100973@unknown@formal@none@1@S@In cases where the program failed to return a result, the sensitivity is 0 and the PPV is undefined.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 33) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "VB") (:stem . "return") (:form . "return") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 69)\n  (:start . 58) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "CD") (:stem . "0") (:form . "0") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "undefined") (:form . "undefined") (:end . 99)\n  (:start . 90) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x3.193.1) (:span 27 33)))\n (:nscopes ((:id . :x3.193.1) (:span 27 52)))\n (:identifiers (:sid . :s3.193) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100974@unknown@formal@none@1@S@Cases where a program did not support the species were not included.@(((:tag . "NNS") (:stem . "case") (:form . "Cases") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "include") (:form . "included") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x3.194.2) (:span 55 58)) ((:id . :x3.194.1) (:span 26 29)))\n (:nscopes ((:id . :x3.194.1) (:span 26 49)) ((:id . :x3.194.2) (:span 0 67)))\n (:identifiers (:sid . :s3.194) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100975@unknown@formal@none@1@S@(b) Ranks on this plot were computed by taking the average of sensitivity and PPV ranks for each program.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "b") (:form . "b") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNS") (:stem . "rank") (:form . "Ranks") (:end . 9) (:start . 4)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 12) (:start . 10)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 47))\n ((:tag . "NN") (:stem . "plot") (:form . "plot") (:end . 22) (:start . 18)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 36)\n  (:start . 28) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "take") (:form . "taking") (:end . 46) (:start . 40)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 58)\n  (:start . 51) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 73)\n  (:start . 62) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "rank") (:form . "ranks") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 60))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 104)\n  (:start . 97) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.195) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100976@unknown@formal@none@1@S@Performance in the presence of extraneous upstream sequences@(((:tag . "NNP") (:stem . "Performance") (:form . "Performance") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 60)\n  (:start . 51) (:id . 49)))@@@1@8@((:identifiers (:sid . :s3.196) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5100977@unknown@formal@none@1@S@In practice, microarray co-expression data are often used to identify genes in a particular regulon.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "practice") (:form . "practice") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "microarray") (:form . "microarray") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "co-expression") (:form . "co-expression")\n  (:end . 37) (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 75) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s3.197) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100978@unknown@formal@none@1@S@This approach identifies genes that are either directly or indirectly regulated by the transcription factor of interest.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "identify") (:form . "identifies") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 30) (:start . 25)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "RB") (:stem . "indirectly") (:form . "indirectly") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 79)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 100) (:start . 87) (:id . 55))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 119)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s3.198) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100980@unknown@formal@none@1@S@Adding sequences that do not contain binding sites decreases the signal-to-noise ratio, making motif finding more difficult 4.@(((:tag . "VBG") (:stem . "add") (:form . "Adding") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "decrease") (:form . "decreases") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "signal-to-noise") (:form . "signal-to-noise")\n  (:end . 80) (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "make") (:form . "making") (:end . 94) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 123)\n  (:start . 114) (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x3.200.1) (:span 25 28)))\n (:nscopes ((:id . :x3.200.1) (:span 25 50)))\n (:identifiers (:sid . :s3.200) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100981@unknown@formal@none@1@S@We thus tested SCOPE's performance on regulons containing additional extraneous upstream sequences.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 68)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.201) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100982@unknown@formal@none@1@S@For all 33 regulons in the SCPD dataset, we added randomly selected upstream S. cerevisiae sequences such that the total number of extraneous sequences was between 0.5 and 4 times the number of true upstream sequences in the regulon.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SCPD") (:form . "SCPD") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 43) (:start . 41)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "add") (:form . "added") (:end . 49) (:start . 44)\n  (:id . 52))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 58)\n  (:start . 50) (:id . 53))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 141)\n  (:start . 131) (:id . 65))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 151)\n  (:start . 142) (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 163)\n  (:start . 156) (:id . 68))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 179)\n  (:start . 174) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 190)\n  (:start . 184) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 198) (:start . 194)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 207)\n  (:start . 199) (:id . 77))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 217)\n  (:start . 208) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 220) (:start . 218)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 80))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 232)\n  (:start . 225) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s3.202) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100983@unknown@formal@none@1@S@SCOPE's accuracy on this dataset was remarkably stable in the presence of extraneous sequences.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "RB") (:stem . "remarkably") (:form . "remarkably") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.203) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100984@unknown@formal@none@1@S@Figure 7 shows the aggregate results of this test, with the SCPD regulons divided into three groups based on SCOPE's accuracy on the true regulon.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "aggregate") (:form . "aggregate") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SCPD") (:form . "SCPD") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 125)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 145)\n  (:start . 138) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.204) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100985@unknown@formal@none@1@S@For each set of regulons, SCOPE's performance decayed gradually as increasing numbers of extraneous genes were added to the regulon.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 45)\n  (:start . 34) (:id . 50))\n ((:tag . "VBD") (:stem . "decay") (:form . "decayed") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "RB") (:stem . "gradually") (:form . "gradually") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 116) (:start . 111)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.205) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100986@unknown@formal@none@1@S@These results were consistent with the relationship between the Sig score and performance on synthetic datasets (Figure 2).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 51)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 89)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "synthetic") (:form . "synthetic") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 111)\n  (:start . 103) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.206) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100987@unknown@formal@none@1@S@Robustness of SCOPE performance on S. cerevisiae regulons containing extraneous upstream sequences@(((:tag . "NNP") (:stem . "Robustness") (:form . "Robustness") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 98)\n  (:start . 89) (:id . 53)))@@@1@12@((:identifiers (:sid . :s3.207) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|FigureLegend|)))@oe@9-2-2011
5100988@unknown@formal@none@1@S@Robustness of SCOPE performance on S. cerevisiae regulons containing extraneous upstream sequences.@(((:tag . "NNP") (:stem . "Robustness") (:form . "Robustness") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 68)\n  (:start . 58) (:id . 50))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 88)\n  (:start . 80) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 98)\n  (:start . 89) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.208) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100990@unknown@formal@none@1@S@The bold red line is the average across all regulons, while each of the other lines represent the performance of SCOPE on one-third of the total S. cerevisiae regulons.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "bold") (:form . "bold") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 93)\n  (:start . 84) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 109)\n  (:start . 98) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "one-third") (:form . "one-third") (:end . 131)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 158)\n  (:start . 148) (:id . 70))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 167)\n  (:start . 159) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s3.210) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100991@unknown@formal@none@1@S@The y-axis shows the average accuracy for each group of regulons.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s3.211) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100992@unknown@formal@none@1@S@The x-axis shows the ratio of extraneous upstream sequences to bona fide ones.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "extraneous") (:form . "extraneous") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "bona") (:form . "bona") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fide") (:form . "fide") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.212) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100993@unknown@formal@none@1@S@Discussion@(((:tag . "NN") (:stem . "discussion") (:form . "Discussion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.213) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5100994@unknown@formal@none@1@S@The field of motif finding is saturated with a large number of algorithms representing myriad search strategies, objective functions and motif models.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "saturate") (:form . "saturated") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 86)\n  (:start . 74) (:id . 55))\n ((:tag . "JJ") (:stem . "myriad") (:form . "myriad") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NNS") (:stem . "strategy") (:form . "strategies") (:end . 111)\n  (:start . 101) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 122)\n  (:start . 113) (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 132)\n  (:start . 123) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 149)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s3.214) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100995@unknown@formal@none@1@S@Yet remarkably, performance comparisons consistently reveal disappointing performance for motif finders and fail to find any statistical significance between them.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "remarkably") (:form . "remarkably") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 52)\n  (:start . 40) (:id . 47))\n ((:tag . "VBP") (:stem . "reveal") (:form . "reveal") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "JJ") (:stem . "disappointing") (:form . "disappointing")\n  (:end . 73) (:start . 60) (:id . 49))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 85)\n  (:start . 74) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 95) (:start . 90)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 103)\n  (:start . 96) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 112) (:start . 108)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 56))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 124) (:start . 121)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 136)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 149)\n  (:start . 137) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 157)\n  (:start . 150) (:id . 61))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 162) (:start . 158)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x3.215.1) (:span 108 112)))\n (:nscopes ((:id . :x3.215.1) (:span 108 162)))\n (:identifiers (:sid . :s3.215) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100996@unknown@formal@none@1@S@A brief survey of the per-regulon results of these performance comparisons yields two key observations: (1) there are many regulons for which a large number of programs find a small portion of the binding sites (though not necessarily the same portion); and (2) every program has a respectable number of "wins" (i.e. every program is the best existing program on some handful of regulons 145678.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "brief") (:form . "brief") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "survey") (:form . "survey") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "per-regulon") (:form . "per-regulon") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "VBZ") (:stem . "yield") (:form . "yields") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . 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"(") (:stem . "(") (:form . "(") (:end . 259) (:start . 258)\n  (:id . 90))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 260) (:start . 259)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 261) (:start . 260)\n  (:id . 92))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 267)\n  (:start . 262) (:id . 93))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 275)\n  (:start . 268) (:id . 94))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 279) (:start . 276)\n  (:id . 95))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 281) (:start . 280)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "respectable") (:form . "respectable") (:end . 293)\n  (:start . 282) (:id . 97))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 300)\n  (:start . 294) (:id . 98))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 303) (:start . 301)\n  (:id . 99))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 305) (:start . 304)\n  (:id . 100))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 309) (:start . 305)\n  (:id . 101))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 310) (:start . 309)\n  (:id . 102))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 312) (:start . 311)\n  (:id . 103))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 316) (:start . 312)\n  (:id . 104))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 322)\n  (:start . 317) (:id . 105))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 330)\n  (:start . 323) (:id . 106))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 333) (:start . 331)\n  (:id . 107))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 337) (:start . 334)\n  (:id . 108))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 342) (:start . 338)\n  (:id . 109))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 351)\n  (:start . 343) (:id . 110))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 359)\n  (:start . 352) (:id . 111))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 362) (:start . 360)\n  (:id . 112))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 367) (:start . 363)\n  (:id . 113))\n ((:tag . "NN") (:stem . "handful") (:form . "handful") (:end . 375)\n  (:start . 368) (:id . 114))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 378) (:start . 376)\n  (:id . 115))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 387)\n  (:start . 379) (:id . 116))\n ((:tag . "CD") (:stem . "145678") (:form . "145678") (:end . 394)\n  (:start . 388) (:id . 117))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 395) (:start . 394)\n  (:id . 118)))@@@1@77@((:identifiers (:sid . :s3.216) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100997@unknown@formal@none@1@S@Such observations are common in many machine learning applications, and are the direct result of complex search spaces that force restrictions on either the search strategy or the representation of the solution space (in this case, the motif model used to represent the motifs).@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "machine") (:form . "machine") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . 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"case") (:end . 230) (:start . 226)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 231) (:start . 230)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 81))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 241)\n  (:start . 236) (:id . 82))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 247)\n  (:start . 242) (:id . 83))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 252) (:start . 248)\n  (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 255) (:start . 253)\n  (:id . 85))\n ((:tag . "VB") (:stem . "represent") (:form . "represent") (:end . 265)\n  (:start . 256) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 269) (:start . 266)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 276)\n  (:start . 270) (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 277) (:start . 276)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s3.217) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5100998@unknown@formal@none@1@S@For example, YMF and RSAT are guaranteed to find the optimal solutions in their motif space (fixed-length motifs with limited degeneracies), but that space is limited to the point that optimality provides no clear advantage over the other methods.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "YMF") (:form . "YMF") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RSAT") (:form . "RSAT") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "guarantee") (:form . "guaranteed") (:end . 40)\n  (:start . 30) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "NNS") (:stem . "solution") (:form . "solutions") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 79)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "fixed-length") (:form . "fixed-length") (:end . 105)\n  (:start . 93) (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "limited") (:form . "limited") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "degeneracy") (:form . "degeneracies") (:end . 138)\n  (:start . 126) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 144) (:start . 141)\n  (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 155)\n  (:start . 150) (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 158) (:start . 156)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 166)\n  (:start . 159) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 73))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 184) (:start . 180)\n  (:id . 75))\n ((:tag . "NN") (:stem . "optimality") (:form . "optimality") (:end . 195)\n  (:start . 185) (:id . 76))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 204)\n  (:start . 196) (:id . 77))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 207) (:start . 205)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 213)\n  (:start . 208) (:id . 79))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 223)\n  (:start . 214) (:id . 80))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 228) (:start . 224)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 238)\n  (:start . 233) (:id . 83))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 246)\n  (:start . 239) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s3.218) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101000@unknown@formal@none@1@S@The HLK ensemble method 4 successfully exploits the first key observation above.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "HLK") (:form . "HLK") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "successfully") (:form . "successfully") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "exploit") (:form . "exploits") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.220) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101001@unknown@formal@none@1@S@By running the same (stochastic) algorithm multiple times and using a voting method, those subsequences of the binding sites that are repeatedly reported become clear while the spurious bases are eliminated.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "run") (:form . "running") (:end . 10) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "stochastic") (:form . "stochastic") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "algorithm") (:form . "algorithm") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "voting") (:form . "voting") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "subsequence") (:form . "subsequences") (:end . 103)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 129) (:start . 125)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "RB") (:stem . "repeatedly") (:form . "repeatedly") (:end . 144)\n  (:start . 134) (:id . 66))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 153)\n  (:start . 145) (:id . 67))\n ((:tag . "VBN") (:stem . "become") (:form . "become") (:end . 160)\n  (:start . 154) (:id . 68))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 172)\n  (:start . 167) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "spurious") (:form . "spurious") (:end . 185)\n  (:start . 177) (:id . 72))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 191)\n  (:start . 186) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 195) (:start . 192)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "eliminate") (:form . "eliminated") (:end . 206)\n  (:start . 196) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s3.221) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101002@unknown@formal@none@1@S@Hu and colleagues report that this method increased accuracy and proposed that their approach may prove effective when running different algorithms as well 4.@(((:tag . "NNP") (:stem . "Hu") (:form . "Hu") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "colleague") (:form . "colleagues") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . "VBP") (:stem . "report") (:form . "report") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "propose") (:form . "proposed") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 84)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VB") (:stem . "prove") (:form . "prove") (:end . 103) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 113)\n  (:start . 104) (:id . 58))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 118) (:start . 114)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "run") (:form . "running") (:end . 126)\n  (:start . 119) (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 136)\n  (:start . 127) (:id . 61))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 147)\n  (:start . 137) (:id . 62))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 63))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 155) (:start . 151)\n  (:id . 64))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x3.222.1) (:span 94 97)) ((:id . :x3.222.2) (:span 65 73)))\n (:hscopes ((:id . :x3.222.1) (:span 94 155))\n  ((:id . :x3.222.2) (:span 65 155)))\n (:identifiers (:sid . :s3.222) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101003@unknown@formal@none@1@S@The limitation arises, however, in regulons where only one program has a high accuracy and the others fail to find any portion of the binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "limitation") (:form . "limitation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "arise") (:form . "arises") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 114) (:start . 110)\n  (:id . 63))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 118) (:start . 115)\n  (:id . 64))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 126)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 141)\n  (:start . 134) (:id . 68))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x3.223.1) (:span 102 106)))\n (:nscopes ((:id . :x3.223.1) (:span 102 147)))\n (:identifiers (:sid . :s3.223) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101004@unknown@formal@none@1@S@In such cases, it is likely that a voting-based ensemble will follow the crowd and fail to find the true binding site.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 27)\n  (:start . 21) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "voting-based") (:form . "voting-based") (:end . 47)\n  (:start . 35) (:id . 51))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 56)\n  (:start . 48) (:id . 52))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "VB") (:stem . "follow") (:form . "follow") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "crowd") (:form . "crowd") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "fail") (:form . "fail") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 104) (:start . 100)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 63))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x3.224.1) (:span 21 27)))\n (:hscopes ((:id . :x3.224.1) (:span 21 117)))\n (:identifiers (:sid . :s3.224) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101005@unknown@formal@none@1@S@The second observation, that all motif finders win some number of regulons and often perform roughly the same on average, is broadly consistent with a theorem in the Machine Learning field referred to as the No Free Lunch Theorem 1819.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "win") (:form . "win") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 74)\n  (:start . 66) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "perform") (:form . "perform") (:end . 92)\n  (:start . 85) (:id . 57))\n ((:tag . "RB") (:stem . "roughly") (:form . "roughly") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "broadly") (:form . "broadly") (:end . 132)\n  (:start . 125) (:id . 65))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 143)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "theorem") (:form . "theorem") (:end . 158)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Machine") (:form . "Machine") (:end . 173)\n  (:start . 166) (:id . 72))\n ((:tag . "NNP") (:stem . "Learning") (:form . "Learning") (:end . 182)\n  (:start . 174) (:id . 73))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 188)\n  (:start . 183) (:id . 74))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 197)\n  (:start . 189) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 203) (:start . 201)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "No") (:form . "No") (:end . 210) (:start . 208)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Free") (:form . "Free") (:end . 215) (:start . 211)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Lunch") (:form . "Lunch") (:end . 221)\n  (:start . 216) (:id . 81))\n ((:tag . "NNP") (:stem . "Theorem") (:form . "Theorem") (:end . 229)\n  (:start . 222) (:id . 82))\n ((:tag . "CD") (:stem . "1819") (:form . "1819") (:end . 234) (:start . 230)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s3.225) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101006@unknown@formal@none@1@S@Briefly, this theorem states that, averaged over all datasets, the performance of all search algorithms are exactly the same, with the corollary that two algorithms will have the exact same number of wins in relation to each other.@(((:tag . "NNP") (:stem . "Briefly") (:form . "Briefly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "theorem") (:form . "theorem") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "state") (:form . "states") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "average") (:form . "averaged") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 78)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 92)\n  (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 103)\n  (:start . 93) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "corollary") (:form . "corollary") (:end . 144)\n  (:start . 135) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 164)\n  (:start . 154) (:id . 70))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 169) (:start . 165)\n  (:id . 71))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 174) (:start . 170)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 189) (:start . 185)\n  (:id . 75))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 196)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 204) (:start . 200)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 207) (:start . 205)\n  (:id . 79))\n ((:tag . "NN") (:stem . "relation") (:form . "relation") (:end . 216)\n  (:start . 208) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 81))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 224) (:start . 220)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 230)\n  (:start . 225) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s3.226) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101007@unknown@formal@none@1@S@In practice, this theorem argues for the use of specialized domain knowledge 20, where available, and may suggest that similar average performance across a diversity of approaches is an indication of the diversity of the datasets themselves.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "practice") (:form . "practice") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "theorem") (:form . "theorem") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "argue") (:form . "argues") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "specialize") (:form . "specialized") (:end . 59)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 113)\n  (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 146)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 153)\n  (:start . 147) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 155) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 179)\n  (:start . 169) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "indication") (:form . "indication") (:end . 196)\n  (:start . 186) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 76))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 213)\n  (:start . 204) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . "PRP") (:stem . "themselves") (:form . "themselves") (:end . 240)\n  (:start . 230) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x3.227.1) (:span 186 196))\n  ((:id . :x3.227.2) (:span 106 113)) ((:id . :x3.227.3) (:span 102 105)))\n (:hscopes ((:id . :x3.227.1) (:span 186 240))\n  ((:id . :x3.227.2) (:span 106 240)) ((:id . :x3.227.3) (:span 102 240)))\n (:identifiers (:sid . :s3.227) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101008@unknown@formal@none@1@S@Thus, motif finders designed for one class of motifs will win on regulons containing those motifs, but will perform poorly on other regulons, while more general motif finders will tend to have more consistently mediocre performance.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "VBN") (:stem . "design") (:form . "designed") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VB") (:stem . "win") (:form . "win") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 73)\n  (:start . 65) (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 107) (:start . 103)\n  (:id . 61))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 115)\n  (:start . 108) (:id . 62))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 140)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 147)\n  (:start . 142) (:id . 68))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 160)\n  (:start . 153) (:id . 70))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 166)\n  (:start . 161) (:id . 71))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 174)\n  (:start . 167) (:id . 72))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 179) (:start . 175)\n  (:id . 73))\n ((:tag . "VB") (:stem . "tend") (:form . "tend") (:end . 184) (:start . 180)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 75))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 197) (:start . 193)\n  (:id . 77))\n ((:tag . "RB") (:stem . "consistently") (:form . "consistently") (:end . 210)\n  (:start . 198) (:id . 78))\n ((:tag . "JJ") (:stem . "mediocre") (:form . "mediocre") (:end . 219)\n  (:start . 211) (:id . 79))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 231)\n  (:start . 220) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x3.228.1) (:span 180 184)))\n (:hscopes ((:id . :x3.228.1) (:span 180 231)))\n (:identifiers (:sid . :s3.228) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101010@unknown@formal@none@1@S@The working hypothesis is, in effect, that the local maxima are predictable (corresponding to one of three motif classes) and exploitable (we can find the local maxima in each class and choose whichever is higher).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "work") (:form . "working") (:end . 11) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "maximum") (:form . "maxima") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "predictable") (:form . "predictable") (:end . 75)\n  (:start . 64) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 90)\n  (:start . 77) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "exploitable") (:form . "exploitable") (:end . 137)\n  (:start . 126) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 150) (:start . 146)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 160)\n  (:start . 155) (:id . 72))\n ((:tag . "NNS") (:stem . "maximum") (:form . "maxima") (:end . 167)\n  (:start . 161) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 74))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 175) (:start . 171)\n  (:id . 75))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 181)\n  (:start . 176) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 77))\n ((:tag . "NN") (:stem . "choose") (:form . "choose") (:end . 192)\n  (:start . 186) (:id . 78))\n ((:tag . "WDT") (:stem . "whichever") (:form . "whichever") (:end . 202)\n  (:start . 193) (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 205) (:start . 203)\n  (:id . 80))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 212)\n  (:start . 206) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x3.230.1) (:span 12 22)))\n (:hscopes ((:id . :x3.230.1) (:span 12 137)))\n (:identifiers (:sid . :s3.230) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101011@unknown@formal@none@1@S@Consistent with this hypothesis, there was very little overlap among the component algorithms of SCOPE (each wins about 20 of the 78 regulons, with very few ties) and, by taking the maximum score from those three local maxima, SCOPE tended to choose the motif with the highest accuracy in a clear majority of the cases (66%, compared to 33% for a random learning rule).@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "little") (:form . "little") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "win") (:form . "wins") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 141)\n  (:start . 133) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . 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5101012@unknown@formal@none@1@S@Furthermore, SCOPE not only significantly outperformed its components on this dataset, it also outperformed a number of general purpose algorithms that seek to find the global maximum in a single pass.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "VBD") (:stem . "outperforme") (:form . "outperformed") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 69)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "outperforme") (:form . "outperformed") (:end . 107)\n  (:start . 95) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "purpose") (:form . "purpose") (:end . 135)\n  (:start . 128) (:id . 62))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "seek") (:form . "seek") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 164) (:start . 160)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "global") (:form . "global") (:end . 175)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 183)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 195)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "pass") (:form . "pass") (:end . 200) (:start . 196)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s3.232) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101013@unknown@formal@none@1@S@Of course, based on the No Free Lunch Theorem, SCOPE's performance averaged over all theoretically possible datasets will still converge to that of the other motif finding approaches (including random guessing).@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "No") (:form . "No") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Free") (:form . "Free") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Lunch") (:form . "Lunch") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Theorem") (:form . "Theorem") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 52) (:start . 47)\n  (:id . 53))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 66)\n  (:start . 55) (:id . 55))\n ((:tag . "VBD") (:stem . "average") (:form . "averaged") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "RB") (:stem . "theoretically") (:form . "theoretically")\n  (:end . 98) (:start . 85) (:id . 59))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 116)\n  (:start . 108) (:id . 61))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "VB") (:stem . "converge") (:form . "converge") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 157)\n  (:start . 152) (:id . 69))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 163)\n  (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 171)\n  (:start . 164) (:id . 71))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 182)\n  (:start . 172) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 200)\n  (:start . 194) (:id . 75))\n ((:tag . "NN") (:stem . "guessing") (:form . "guessing") (:end . 209)\n  (:start . 201) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s3.233) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101014@unknown@formal@none@1@S@As the physical properties of transcription factors will inevitably constrain the structure of their binding sites, biologically relevant datasets comprise a subset of the space of all theoretically possible sequences.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 43) (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 51)\n  (:start . 44) (:id . 48))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "RB") (:stem . "inevitably") (:form . "inevitably") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "VB") (:stem . "constrain") (:form . "constrain") (:end . 77)\n  (:start . 68) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 91)\n  (:start . 82) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 100)\n  (:start . 95) (:id . 55))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 114)\n  (:start . 109) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 128)\n  (:start . 116) (:id . 59))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "VBP") (:stem . "comprise") (:form . "comprise") (:end . 155)\n  (:start . 147) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 157) (:start . 156)\n  (:id . 63))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 164)\n  (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 177)\n  (:start . 172) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "RB") (:stem . "all") (:form . "all") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "RB") (:stem . "theoretically") (:form . "theoretically")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 207)\n  (:start . 199) (:id . 71))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 217)\n  (:start . 208) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s3.234) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101015@unknown@formal@none@1@S@Our test set of 78 regulons was selected in a blinded manner (for details, see Additional file 1, section S3), thus these results suggest the generalizability of SCOPE's use of domain knowledge on biologically relevant datasets from these species.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "CD") (:stem . "78") (:form . "78") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "blind") (:form . "blinded") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 73)\n  (:start . 66) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 78) (:start . 75)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 89)\n  (:start . 79) (:id . 59))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 62))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 105)\n  (:start . 98) (:id . 63))\n ((:tag . "NN") (:stem . "s3") (:form . "S3") (:end . 108) (:start . 106)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 66))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 115) (:start . 111)\n  (:id . 67))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 121)\n  (:start . 116) (:id . 68))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 129)\n  (:start . 122) (:id . 69))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 137)\n  (:start . 130) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 71))\n ((:tag . "NN") (:stem . "generalizability") (:form . "generalizability")\n  (:end . 158) (:start . 142) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 161) (:start . 159)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 167)\n  (:start . 162) (:id . 74))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 169) (:start . 167)\n  (:id . 75))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 173) (:start . 170)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 77))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 183)\n  (:start . 177) (:id . 78))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 193)\n  (:start . 184) (:id . 79))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 196) (:start . 194)\n  (:id . 80))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 209)\n  (:start . 197) (:id . 81))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 218)\n  (:start . 210) (:id . 82))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 227)\n  (:start . 219) (:id . 83))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 232) (:start . 228)\n  (:id . 84))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 238)\n  (:start . 233) (:id . 85))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 246)\n  (:start . 239) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 247) (:start . 246)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x3.235.1) (:span 130 137)))\n (:hscopes ((:id . :x3.235.1) (:span 130 246)))\n (:identifiers (:sid . :s3.235) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101016@unknown@formal@none@1@S@These observations are not offered as definitive proof that there are only three classes of motifs; rather, they show that power can be gained by identifying distinct motif classes and combining specialized algorithms with a unified scoring rule.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "offer") (:form . "offered") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "definitive") (:form . "definitive") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "proof") (:form . "proof") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 128)\n  (:start . 123) (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 132) (:start . 129)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "gain") (:form . "gained") (:end . 142)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 157)\n  (:start . 146) (:id . 69))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 180)\n  (:start . 173) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "combine") (:form . "combining") (:end . 194)\n  (:start . 185) (:id . 74))\n ((:tag . "VBN") (:stem . "specialize") (:form . "specialized") (:end . 206)\n  (:start . 195) (:id . 75))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 217)\n  (:start . 207) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 222) (:start . 218)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 224) (:start . 223)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "unified") (:form . "unified") (:end . 232)\n  (:start . 225) (:id . 79))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 240)\n  (:start . 233) (:id . 80))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 245) (:start . 241)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 82)))@@@1@41@((:ncues ((:id . :x3.236.1) (:span 23 26)))\n (:nscopes ((:id . :x3.236.1) (:span 0 98)))\n (:identifiers (:sid . :s3.236) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101017@unknown@formal@none@1@S@It is possible that more power could be gained by identifying other distinct motif classes and adding algorithms that explicitly search for those classes.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "gain") (:form . "gained") (:end . 46) (:start . 40)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "identify") (:form . "identifying") (:end . 61)\n  (:start . 50) (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "add") (:form . "adding") (:end . 101) (:start . 95)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 60))\n ((:tag . "RB") (:stem . "explicitly") (:form . "explicitly") (:end . 128)\n  (:start . 118) (:id . 61))\n ((:tag . "VBP") (:stem . "search") (:form . "search") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 139) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x3.237.1) (:span 31 36)) ((:id . :x3.237.2) (:span 6 14)))\n (:hscopes ((:id . :x3.237.1) (:span 20 153))\n  ((:id . :x3.237.2) (:span 6 153)))\n (:identifiers (:sid . :s3.237) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101018@unknown@formal@none@1@S@For example, Zinc finger transcription factors have been demonstrated to bind three triplets of nucleotides which overlap at their third base positions 21.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Zinc") (:form . "Zinc") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 38) (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "triplet") (:form . "triplets") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 121)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 136)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "base") (:form . "base") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 154) (:start . 152)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s3.238) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101020@unknown@formal@none@1@S@Thus, all nondegenerate triplets in a set of upstream regions could be scored and the highest-scoring triplets combined into a single five-mer with a two-base degeneracy (corresponding to the IUPAC characters R,Y, W, S, K or M) at the middle position.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "nondegenerate") (:form . "nondegenerate")\n  (:end . 23) (:start . 10) (:id . 45))\n ((:tag . "NNS") (:stem . "triplet") (:form . "triplets") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "score") (:form . "scored") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "highest-scoring") (:form . "highest-scoring")\n  (:end . 101) (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "triplet") (:form . "triplets") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "NN") (:stem . "five-mer") (:form . "five-mer") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "two-base") (:form . "two-base") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . "NN") (:stem . "degeneracy") (:form . "degeneracy") (:end . 169)\n  (:start . 159) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 184)\n  (:start . 171) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "IUPAC") (:form . "IUPAC") (:end . 197)\n  (:start . 192) (:id . 73))\n ((:tag . "NNS") (:stem . "character") (:form . "characters") (:end . 208)\n  (:start . 198) (:id . 74))\n ((:tag . "NNP") (:stem . "R,Y") (:form . "R,Y") (:end . 212) (:start . 209)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "W") (:form . "W") (:end . 215) (:start . 214)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 216) (:start . 215)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 218) (:start . 217)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 221) (:start . 220)\n  (:id . 81))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 224) (:start . 222)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 226) (:start . 225)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 227) (:start . 226)\n  (:id . 84))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 230) (:start . 228)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 234) (:start . 231)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "middle") (:form . "middle") (:end . 241)\n  (:start . 235) (:id . 87))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 250)\n  (:start . 242) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x3.240.1) (:span 62 67)))\n (:hscopes ((:id . :x3.240.1) (:span 6 77)))\n (:identifiers (:sid . :s3.240) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101021@unknown@formal@none@1@S@The highest-scoring five-mers could then be combined with the highest scoring triplets to generate a seven-mer with two-base degeneracies at positions three and five.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "highest-scoring") (:form . "highest-scoring")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "five-mer") (:form . "five-mers") (:end . 29)\n  (:start . 20) (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 35) (:start . 30)\n  (:id . 45))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "triplet") (:form . "triplets") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "seven-mer") (:form . "seven-mer") (:end . 110)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "two-base") (:form . "two-base") (:end . 124)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "degeneracy") (:form . "degeneracies") (:end . 137)\n  (:start . 125) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 140) (:start . 138)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 150)\n  (:start . 141) (:id . 62))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 156)\n  (:start . 151) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 64))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 165) (:start . 161)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x3.241.1) (:span 30 35)))\n (:hscopes ((:id . :x3.241.1) (:span 0 165)))\n (:identifiers (:sid . :s3.241) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101022@unknown@formal@none@1@S@Provided the appropriate Bonferroni correction is applied for this new class of motifs, these motifs may be easily compared with the results from BEAM, PRISM and SPACER, thereby extending the SCOPE ensemble to include a fourth class of motifs.@(((:tag . "VBN") (:stem . "provide") (:form . "Provided") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "appropriate") (:form . "appropriate") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NNP") (:stem . "Bonferroni") (:form . "Bonferroni") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 46)\n  (:start . 36) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "RB") (:stem . "easily") (:form . "easily") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 140)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BEAM") (:form . "BEAM") (:end . 150) (:start . 146)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "prism") (:form . "PRISM") (:end . 157)\n  (:start . 152) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "SPACER") (:form . "SPACER") (:end . 168)\n  (:start . 162) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 177)\n  (:start . 170) (:id . 72))\n ((:tag . "VBG") (:stem . "extend") (:form . "extending") (:end . 187)\n  (:start . 178) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 197)\n  (:start . 192) (:id . 75))\n ((:tag . "VB") (:stem . "ensemble") (:form . "ensemble") (:end . 206)\n  (:start . 198) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 209) (:start . 207)\n  (:id . 77))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 217)\n  (:start . 210) (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 219) (:start . 218)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "fourth") (:form . "fourth") (:end . 226)\n  (:start . 220) (:id . 80))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 232)\n  (:start . 227) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 242)\n  (:start . 236) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x3.242.1) (:span 101 104)))\n (:hscopes ((:id . :x3.242.1) (:span 88 168)))\n (:identifiers (:sid . :s3.242) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101023@unknown@formal@none@1@S@We note, however, that as more methods are added to SCOPE, it will be increasingly difficult to devise a scoring metric that can accurately choose the best result from among the components.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 30) (:start . 26)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 38)\n  (:start . 31) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 48) (:start . 43)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 61) (:start . 59)\n  (:id . 56))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 66) (:start . 62)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 58))\n ((:tag . "RB") (:stem . "increasingly") (:form . "increasingly") (:end . 82)\n  (:start . 70) (:id . 59))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 92)\n  (:start . 83) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 61))\n ((:tag . "VB") (:stem . "devise") (:form . "devise") (:end . 102)\n  (:start . 96) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 112)\n  (:start . 105) (:id . 64))\n ((:tag . "NN") (:stem . "metric") (:form . "metric") (:end . 119)\n  (:start . 113) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 128) (:start . 125)\n  (:id . 67))\n ((:tag . "RB") (:stem . "accurately") (:form . "accurately") (:end . 139)\n  (:start . 129) (:id . 68))\n ((:tag . "VB") (:stem . "choose") (:form . "choose") (:end . 146)\n  (:start . 140) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 70))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 155) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 162)\n  (:start . 156) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 167) (:start . 163)\n  (:id . 73))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 173)\n  (:start . 168) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 177) (:start . 174)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 188)\n  (:start . 178) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s3.243) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101024@unknown@formal@none@1@S@SCOPE may also serve as a complementary approach to the HLK method.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 39) (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "HLK") (:form . "HLK") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x3.244.1) (:span 6 9)))\n (:hscopes ((:id . :x3.244.1) (:span 6 66)))\n (:identifiers (:sid . :s3.244) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101025@unknown@formal@none@1@S@For example, the parameters of many methods can be set to search for specific classes of motifs (such as bipartite versus non-bipartite motifs).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 27)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "VB") (:stem . "search") (:form . "search") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 77)\n  (:start . 69) (:id . 56))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 85)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 101) (:start . 97)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "bipartite") (:form . "bipartite") (:end . 114)\n  (:start . 105) (:id . 63))\n ((:tag . "IN") (:stem . "versus") (:form . "versus") (:end . 121)\n  (:start . 115) (:id . 64))\n ((:tag . "JJ") (:stem . "non-bipartite") (:form . "non-bipartite")\n  (:end . 135) (:start . 122) (:id . 65))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 142)\n  (:start . 136) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s3.245) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101026@unknown@formal@none@1@S@Thus, analogous to the ensemble method described in this paper, one may build a hierarchical ensemble that first searches each motif class by the HLK method using a number of algorithms or random restarts, and then uses the SCOPE method to choose the best result from among the motif classes.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "analogous") (:form . "analogous") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "one") (:form . "one") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "VB") (:stem . "build") (:form . "build") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hierarchical") (:form . "hierarchical") (:end . 92)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 101)\n  (:start . 93) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 112)\n  (:start . 107) (:id . 61))\n ((:tag . "VBZ") (:stem . "search") (:form . "searches") (:end . 121)\n  (:start . 113) (:id . 62))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HLK") (:form . "HLK") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 156)\n  (:start . 150) (:id . 69))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 162) (:start . 157)\n  (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 171)\n  (:start . 165) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 185)\n  (:start . 175) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 188) (:start . 186)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 195)\n  (:start . 189) (:id . 76))\n ((:tag . "NNS") (:stem . "restart") (:form . "restarts") (:end . 204)\n  (:start . 196) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 79))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 214) (:start . 210)\n  (:id . 80))\n ((:tag . "VBZ") (:stem . "use") (:form . "uses") (:end . 219) (:start . 215)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 229)\n  (:start . 224) (:id . 83))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 236)\n  (:start . 230) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 239) (:start . 237)\n  (:id . 85))\n ((:tag . "VB") (:stem . "choose") (:form . "choose") (:end . 246)\n  (:start . 240) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 250) (:start . 247)\n  (:id . 87))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 255) (:start . 251)\n  (:id . 88))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 262)\n  (:start . 256) (:id . 89))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 267) (:start . 263)\n  (:id . 90))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 273)\n  (:start . 268) (:id . 91))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 277) (:start . 274)\n  (:id . 92))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 283)\n  (:start . 278) (:id . 93))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 291)\n  (:start . 284) (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x3.246.1) (:span 68 71)))\n (:hscopes ((:id . :x3.246.1) (:span 68 291)))\n (:identifiers (:sid . :s3.246) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101027@unknown@formal@none@1@S@One constraint associated with such an approach is the run-time.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "constraint") (:form . "constraint") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 25)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "run-time") (:form . "run-time") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s3.247) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101028@unknown@formal@none@1@S@A second constraint associated with a hierarchical ensemble learning method is the multiplicative increase in the number of parameters associated with it, though this problem may be ameliorated by the use of parameter-free algorithms that employ restricted search spaces.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "constraint") (:form . "constraint") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "hierarchical") (:form . "hierarchical") (:end . 50)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "ensemble") (:form . "ensemble") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiplicative") (:form . "multiplicative")\n  (:end . 97) (:start . 83) (:id . 54))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 120)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 145)\n  (:start . 135) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 153) (:start . 151)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 161)\n  (:start . 155) (:id . 65))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 166) (:start . 162)\n  (:id . 66))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "ameliorate") (:form . "ameliorated") (:end . 193)\n  (:start . 182) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 196) (:start . 194)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 204) (:start . 201)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 207) (:start . 205)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "parameter-free") (:form . "parameter-free")\n  (:end . 222) (:start . 208) (:id . 75))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 233)\n  (:start . 223) (:id . 76))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 238) (:start . 234)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "employ") (:form . "employ") (:end . 245)\n  (:start . 239) (:id . 78))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 256)\n  (:start . 246) (:id . 79))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 263)\n  (:start . 257) (:id . 80))\n ((:tag . "NNS") (:stem . "space") (:form . "spaces") (:end . 270)\n  (:start . 264) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 271) (:start . 270)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x3.248.1) (:span 175 178)))\n (:hscopes ((:id . :x3.248.1) (:span 162 270)))\n (:identifiers (:sid . :s3.248) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101030@unknown@formal@none@1@S@Certainly to maintain statistical validity, some correction must be made for multiple hypothesis testing.@(((:tag . "RB") (:stem . "certainly") (:form . "Certainly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "VB") (:stem . "maintain") (:form . "maintain") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "validity") (:form . "validity") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.250) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101031@unknown@formal@none@1@S@Furthermore, the effects of multiple testing may bias the results in favor of one of the component algorithms.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "bias") (:form . "bias") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "favor") (:form . "favor") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 109)\n  (:start . 99) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x3.251.1) (:span 45 48)))\n (:hscopes ((:id . :x3.251.1) (:span 45 109)))\n (:identifiers (:sid . :s3.251) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101032@unknown@formal@none@1@S@To ensure statistical validity and avoid such a bias, we developed a simple Bonferroni-like correction, which penalized every proposed motif proportional to its length and degree of degeneracy, resulting in a modest improvement of 8% in SCOPE's accuracy.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "validity") (:form . "validity") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 66)\n  (:start . 57) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "JJ") (:stem . "bonferroni-like") (:form . "Bonferroni-like")\n  (:end . 91) (:start . 76) (:id . 56))\n ((:tag . "NN") (:stem . "correction") (:form . "correction") (:end . 102)\n  (:start . 92) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "VBD") (:stem . "penalize") (:form . "penalized") (:end . 119)\n  (:start . 110) (:id . 60))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 125)\n  (:start . 120) (:id . 61))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "JJ") (:stem . "proportional") (:form . "proportional") (:end . 153)\n  (:start . 141) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 167)\n  (:start . 161) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 178)\n  (:start . 172) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . "NN") (:stem . "degeneracy") (:form . "degeneracy") (:end . 192)\n  (:start . 182) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 193) (:start . 192)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 203)\n  (:start . 194) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 208) (:start . 207)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "modest") (:form . "modest") (:end . 215)\n  (:start . 209) (:id . 76))\n ((:tag . "NN") (:stem . "improvement") (:form . "improvement") (:end . 227)\n  (:start . 216) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 230) (:start . 228)\n  (:id . 78))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 232) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 233) (:start . 232)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 242)\n  (:start . 237) (:id . 82))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 244) (:start . 242)\n  (:id . 83))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 253)\n  (:start . 245) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s3.252) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101033@unknown@formal@none@1@S@Although our test set of 78 regulons gave us enough power to find significance between SCOPE and its components or other algorithms, it did not provide enough power to disentangle the effects of small improvements (such as the Bonferroni correction, the objective function that takes position bias into account, or scoring motifs based off one or both strands), especially in the rigorous cross-validation framework necessary to decipher precisely which aspects contribute significantly to the performance.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . 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(:end . 506) (:start . 505)\n  (:id . 123)))@@@1@82@((:ncues ((:id . :x3.253.1) (:span 140 143)))\n (:nscopes ((:id . :x3.253.1) (:span 140 505)))\n (:identifiers (:sid . :s3.253) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101034@unknown@formal@none@1@S@Nevertheless, as larger datasets become available, SCOPE's efficient search strategy makes it an ideal platform for exploring the effect of focused improvements to the motif finding approach described, such as the use of complex objective functions that may better approximate biological significance.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "dataset") (:form . "datasets") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBP") (:stem . "become") (:form . "become") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "available") (:form . 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(:end . 301) (:start . 300)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x3.254.1) (:span 254 257)))\n (:hscopes ((:id . :x3.254.1) (:span 254 300)))\n (:identifiers (:sid . :s3.254) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101035@unknown@formal@none@1@S@The comparisons to other motif finding programs in this study are provided to place SCOPE's performance in the broader context of the motif finding field, particularly when viewed from the standpoint of the practicing "bench" biologist.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "VB") (:stem . "place") (:form . "place") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJR") (:stem . "broad") (:form . "broader") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 126)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 167)\n  (:start . 155) (:id . 69))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "view") (:form . "viewed") (:end . 179)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "standpoint") (:form . "standpoint") (:end . 199)\n  (:start . 189) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 76))\n ((:tag . "NN") (:stem . "practicing") (:form . "practicing") (:end . 217)\n  (:start . 207) (:id . 77))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "NN") (:stem . "bench") (:form . "bench") (:end . 224)\n  (:start . 219) (:id . 79))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 225) (:start . 224)\n  (:id . 80))\n ((:tag . "NN") (:stem . "biologist") (:form . "biologist") (:end . 235)\n  (:start . 226) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s3.255) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101036@unknown@formal@none@1@S@Any performance comparison must be interpreted with caution, since the results are highly dependent on the dataset used, the conditions of the testing and the metrics used for evaluation.@(((:tag . "DT") (:stem . "any") (:form . "Any") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "interpret") (:form . "interpreted") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "caution") (:form . "caution") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 50))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "dependent") (:form . "dependent") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "testing") (:form . "testing") (:end . 150)\n  (:start . 143) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "metric") (:form . "metrics") (:end . 166)\n  (:start . 159) (:id . 69))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 171) (:start . 167)\n  (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "NN") (:stem . "evaluation") (:form . "evaluation") (:end . 186)\n  (:start . 176) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s3.256) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101037@unknown@formal@none@1@S@With this in mind, we sought to evaluate a wide representation of motif finders on a large number of regulons using performance metrics consistent with previous studies 67.@(((:tag . "IN") (:stem . "with") (:form . "With") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mind") (:form . "mind") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "seek") (:form . "sought") (:end . 28) (:start . 22)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 40)\n  (:start . 32) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 47) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "representation") (:form . "representation")\n  (:end . 62) (:start . 48) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 97)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 115) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 127)\n  (:start . 116) (:id . 64))\n ((:tag . "NNS") (:stem . "metric") (:form . "metrics") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 146)\n  (:start . 136) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 160)\n  (:start . 152) (:id . 68))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "CD") (:stem . "67") (:form . "67") (:end . 171) (:start . 169)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s3.257) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101038@unknown@formal@none@1@S@To the best of our knowledge, this dataset represents the largest set of biologically relevant regulons used for performance comparisons to date.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 28)\n  (:start . 19) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "JJS") (:stem . "large") (:form . "largest") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 85)\n  (:start . 73) (:id . 56))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 136)\n  (:start . 125) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 144) (:start . 140)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s3.258) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101040@unknown@formal@none@1@S@Our comparison thus complements the recent large scale study of Tompa et al., who gauge performance under optimal conditions on semi-synthetic data sets 5, as well as the study of Hu et al., who explore the effect of parameter optimization on a handful of popular motif finders 4.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "complement") (:form . "complements") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tompa") (:form . "Tompa") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "gauge") (:form . "gauge") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 99)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 124)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "semi-synthetic") (:form . "semi-synthetic")\n  (:end . 142) (:start . 128) (:id . 63))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 147)\n  (:start . 143) (:id . 64))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 163) (:start . 159)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 71))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 176)\n  (:start . 171) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Hu") (:form . "Hu") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 185) (:start . 183)\n  (:id . 75))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 189) (:start . 186)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 77))\n ((:tag . "WP") (:stem . "who") (:form . "who") (:end . 194) (:start . 191)\n  (:id . 78))\n ((:tag . "VBP") (:stem . "explore") (:form . "explore") (:end . 202)\n  (:start . 195) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 80))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 213)\n  (:start . 207) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 82))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 226)\n  (:start . 217) (:id . 83))\n ((:tag . "NN") (:stem . "optimization") (:form . "optimization") (:end . 239)\n  (:start . 227) (:id . 84))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 242) (:start . 240)\n  (:id . 85))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 244) (:start . 243)\n  (:id . 86))\n ((:tag . "NN") (:stem . "handful") (:form . "handful") (:end . 252)\n  (:start . 245) (:id . 87))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 255) (:start . 253)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "popular") (:form . "popular") (:end . 263)\n  (:start . 256) (:id . 89))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 269)\n  (:start . 264) (:id . 90))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 277)\n  (:start . 270) (:id . 91))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 279) (:start . 278)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s3.260) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101041@unknown@formal@none@1@S@Although the present philosophy of performance comparison implicitly benefits SCOPE, which has no parameters to optimize, it is arguably the most relevant comparison possible for the typical biologist.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "philosophy") (:form . "philosophy") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . "RB") (:stem . "implicitly") (:form . "implicitly") (:end . 68)\n  (:start . 58) (:id . 49))\n ((:tag . "VBZ") (:stem . "benefit") (:form . "benefits") (:end . 77)\n  (:start . 69) (:id . 50))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 83) (:start . 78)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 94) (:start . 91)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "VB") (:stem . "optimize") (:form . "optimize") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "RB") (:stem . "arguably") (:form . "arguably") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 63))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 154)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 165)\n  (:start . 155) (:id . 66))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 174)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 190)\n  (:start . 183) (:id . 70))\n ((:tag . "NN") (:stem . "biologist") (:form . "biologist") (:end . 200)\n  (:start . 191) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x3.261.1) (:span 95 97)))\n (:nscopes ((:id . :x3.261.1) (:span 95 120)))\n (:identifiers (:sid . :s3.261) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101042@unknown@formal@none@1@S@Although previous studies have shown the potential importance of choosing parameters carefully 46, we note that the results we obtained under default settings were quite similar to those reported in previous studies (for details, see Additional file 1, section S3).@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "choose") (:form . "choosing") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 84)\n  (:start . 74) (:id . 52))\n ((:tag . "RB") (:stem . "carefully") (:form . "carefully") (:end . 94)\n  (:start . 85) (:id . 53))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 97) (:start . 95)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "note") (:form . "note") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "obtain") (:form . "obtained") (:end . 135)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "default") (:form . "default") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "setting") (:form . "settings") (:end . 158)\n  (:start . 150) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 163) (:start . 159)\n  (:id . 66))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 169)\n  (:start . 164) (:id . 67))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 177)\n  (:start . 170) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 186)\n  (:start . 181) (:id . 70))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 195)\n  (:start . 187) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 207)\n  (:start . 199) (:id . 73))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 215)\n  (:start . 208) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 217) (:start . 216)\n  (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 220) (:start . 217)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 228)\n  (:start . 221) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 229) (:start . 228)\n  (:id . 78))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 233) (:start . 230)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 244)\n  (:start . 234) (:id . 80))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 249) (:start . 245)\n  (:id . 81))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 251) (:start . 250)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 252) (:start . 251)\n  (:id . 83))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 260)\n  (:start . 253) (:id . 84))\n ((:tag . "NN") (:stem . "s3") (:form . "S3") (:end . 263) (:start . 261)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 264) (:start . 263)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x3.262.1) (:span 41 50)))\n (:hscopes ((:id . :x3.262.1) (:span 41 94)))\n (:identifiers (:sid . :s3.262) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101043@unknown@formal@none@1@S@Arguably, systematic parameter optimization for each of these programs may well yield higher accuracy scores than those reported here.@(((:tag . "RB") (:stem . "arguably") (:form . "Arguably") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "systematic") (:form . "systematic") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "optimization") (:form . "optimization") (:end . 43)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 47))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "VB") (:stem . "yield") (:form . "yield") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 92) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "score") (:form . "scores") (:end . 108)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 119)\n  (:start . 114) (:id . 59))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x3.263.1) (:span 71 74)))\n (:hscopes ((:id . :x3.263.1) (:span 71 133)))\n (:identifiers (:sid . :s3.263) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101044@unknown@formal@none@1@S@However, in order to avoid the pitfall of overfitting to the dataset, such parameter optimization must be performed using cross-validation or some other resampling technique 92223.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pitfall") (:form . "pitfall") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "overfitte") (:form . "overfitting") (:end . 53)\n  (:start . 42) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "parameter") (:form . "parameter") (:end . 84)\n  (:start . 75) (:id . 57))\n ((:tag . "NN") (:stem . "optimization") (:form . "optimization") (:end . 97)\n  (:start . 85) (:id . 58))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 115)\n  (:start . 106) (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 121) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cross-validation") (:form . "cross-validation")\n  (:end . 138) (:start . 122) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 141) (:start . 139)\n  (:id . 64))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 152)\n  (:start . 147) (:id . 66))\n ((:tag . "VBG") (:stem . "resample") (:form . "resampling") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "NN") (:stem . "technique") (:form . "technique") (:end . 173)\n  (:start . 164) (:id . 68))\n ((:tag . "CD") (:stem . "92223") (:form . "92223") (:end . 179)\n  (:start . 174) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s3.264) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101045@unknown@formal@none@1@S@We note that all the motif finders tested, including SCOPE, performed poorly on the Drosophila dataset.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 41) (:start . 35)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "RB") (:stem . "poorly") (:form . "poorly") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 94)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.265) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101046@unknown@formal@none@1@S@Although SCOPE had the highest accuracy on this dataset, that accuracy was significantly less than on the bacterial and yeast data.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "high") (:form . "highest") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 130)\n  (:start . 126) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.266) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101047@unknown@formal@none@1@S@Especially poor performance on Drosophila was also reported in the Tompa et al. performance comparison, indicating that this difficulty is not limited to the current dataset 5.@(((:tag . "RB") (:stem . "especially") (:form . "Especially") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Tompa") (:form . "Tompa") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 114)\n  (:start . 104) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "NN") (:stem . "difficulty") (:form . "difficulty") (:end . 135)\n  (:start . 125) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "limit") (:form . "limited") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 165)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "dataset") (:form . "dataset") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x3.267.2) (:span 104 119)))\n (:ncues ((:id . :x3.267.1) (:span 139 142)))\n (:hscopes ((:id . :x3.267.2) (:span 104 173)))\n (:nscopes ((:id . :x3.267.1) (:span 120 173)))\n (:identifiers (:sid . :s3.267) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101048@unknown@formal@none@1@S@One possible cause of poor performance in this study is that the ""regulons"" are derived from enhancer regions defined in an earlier computational paper 24.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "”regulons") (:form . "”regulons") (:end . 75)\n  (:start . 66) (:id . 55))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 89)\n  (:start . 82) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 111)\n  (:start . 104) (:id . 62))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 119)\n  (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 125) (:start . 123)\n  (:id . 65))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 133)\n  (:start . 126) (:id . 66))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 147) (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 153)\n  (:start . 148) (:id . 68))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x3.268.1) (:span 4 12)))\n (:hscopes ((:id . :x3.268.1) (:span 4 153)))\n (:identifiers (:sid . :s3.268) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101050@unknown@formal@none@1@S@Thus, the background sequences used by SCOPE and the other programs may not be representative of the ""true"" background model of enhancers, leading to inaccurate statistics.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 20)\n  (:start . 10) (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 58) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "representative") (:form . "representative")\n  (:end . 93) (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "``") (:stem . "``") (:form . "“") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "”true") (:form . "”true") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "''") (:stem . "''") (:form . "”") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 120)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 126)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "enhancer") (:form . "enhancers") (:end . 139)\n  (:start . 130) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 148)\n  (:start . 141) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "inaccurate") (:form . "inaccurate") (:end . 162)\n  (:start . 152) (:id . 71))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 173)\n  (:start . 163) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x3.270.2) (:span 68 71)))\n (:ncues ((:id . :x3.270.1) (:span 72 75)))\n (:hscopes ((:id . :x3.270.2) (:span 68 173)))\n (:nscopes ((:id . :x3.270.1) (:span 72 173)))\n (:identifiers (:sid . :s3.270) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101051@unknown@formal@none@1@S@The persistently poor performance of motif finders on Drosophila regulons thus highlights the importance of using well-defined background sequences to calibrate the statistics of the objective functions being optimized.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "persistently") (:form . "persistently") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "poor") (:form . "poor") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 33)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 64)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "highlight") (:form . "highlights") (:end . 89)\n  (:start . 79) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "importance") (:form . "importance") (:end . 104)\n  (:start . 94) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 113) (:start . 108)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "well-defined") (:form . "well-defined") (:end . 126)\n  (:start . 114) (:id . 58))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 137)\n  (:start . 127) (:id . 59))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 147)\n  (:start . 138) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 150) (:start . 148)\n  (:id . 61))\n ((:tag . "VB") (:stem . "calibrate") (:form . "calibrate") (:end . 160)\n  (:start . 151) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 175)\n  (:start . 165) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 192)\n  (:start . 183) (:id . 67))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 202)\n  (:start . 193) (:id . 68))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 208) (:start . 203)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "optimize") (:form . "optimized") (:end . 218)\n  (:start . 209) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s3.271) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101052@unknown@formal@none@1@S@Recently, algorithms have been reported that predict enhancer regions on a genome wide scale [2425262728].@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "CD") (:stem . "2425262728") (:form . "2425262728") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.272) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101053@unknown@formal@none@1@S@It is possible that using such algorithms to define a collection of background enhancer sequences may improve the performance of SCOPE, as well as that of the other motif finders, on Drosophila.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "algorithm") (:form . "algorithms") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "collection") (:form . "collection") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "enhancer") (:form . "enhancer") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 97)\n  (:start . 88) (:id . 56))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "VB") (:stem . "improve") (:form . "improve") (:end . 109)\n  (:start . 102) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 178)\n  (:start . 171) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 193)\n  (:start . 183) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x3.273.1) (:span 98 101)) ((:id . :x3.273.2) (:span 6 14)))\n (:hscopes ((:id . :x3.273.1) (:span 98 193))\n  ((:id . :x3.273.2) (:span 6 193)))\n (:identifiers (:sid . :s3.273) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101054@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.274) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5101055@unknown@formal@none@1@S@Ensemble methods hold the potential for providing improvements in motif finding accuracy without resorting to the use of additional data (such as phylogenetic information or characterization of the domain structure of the transcription factor), which are not always available.@(((:tag . "JJ") (:stem . "ensemble") (:form . "Ensemble") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "hold") (:form . "hold") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "potential") (:form . "potential") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "improvement") (:form . "improvements") (:end . 62)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "find") (:form . "finding") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 88)\n  (:start . 80) (:id . 53))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . "VBG") (:stem . "resorte") (:form . "resorting") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 57))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 131)\n  (:start . 121) (:id . 60))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 136)\n  (:start . 132) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 142) (:start . 138)\n  (:id . 63))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 158)\n  (:start . 146) (:id . 65))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 170)\n  (:start . 159) (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "characterization") (:form . "characterization")\n  (:end . 190) (:start . 174) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 204)\n  (:start . 198) (:id . 71))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 214)\n  (:start . 205) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 217) (:start . 215)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 235) (:start . 222) (:id . 75))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 242)\n  (:start . 236) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 243) (:start . 242)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 244) (:start . 243)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 250)\n  (:start . 245) (:id . 79))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 254) (:start . 251)\n  (:id . 80))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 258) (:start . 255)\n  (:id . 81))\n ((:tag . "RB") (:stem . "always") (:form . "always") (:end . 265)\n  (:start . 259) (:id . 82))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 275)\n  (:start . 266) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x3.275.1) (:span 89 96)))\n (:nscopes ((:id . :x3.275.1) (:span 89 275)))\n (:identifiers (:sid . :s3.275) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101056@unknown@formal@none@1@S@Typically, ensemble learning methods are plagued with certain liabilities, such as increased runtimes, logistical complexity and a multiplicity of nuisance parameters, all of which grow with the number of programs run.@(((:tag . "RB") (:stem . "typically") (:form . "Typically") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VB") (:stem . "ensemble") (:form . "ensemble") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "plague") (:form . "plagued") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNS") (:stem . "liability") (:form . "liabilities") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NNS") (:stem . "runtime") (:form . "runtimes") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "logistical") (:form . "logistical") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "complexity") (:form . "complexity") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . "NN") (:stem . "multiplicity") (:form . "multiplicity") (:end . 143)\n  (:start . 131) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 166)\n  (:start . 156) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 171) (:start . 168)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 180)\n  (:start . 175) (:id . 69))\n ((:tag . "VBP") (:stem . "grow") (:form . "grow") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 190) (:start . 186)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 194) (:start . 191)\n  (:id . 72))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 201)\n  (:start . 195) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 204) (:start . 202)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 213)\n  (:start . 205) (:id . 75))\n ((:tag . "VBP") (:stem . "run") (:form . "run") (:end . 217) (:start . 214)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s3.276) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101057@unknown@formal@none@1@S@In the machine learning field, ensemble methods have coexisted for many years with non-ensemble methods, with no clear superiority having been established between the two.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "machine") (:form . "machine") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "learning") (:form . "learning") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ensemble") (:form . "ensemble") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "coexist") (:form . "coexisted") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "non-ensemble") (:form . "non-ensemble") (:end . 95)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "superiority") (:form . "superiority") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 162)\n  (:start . 155) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s3.277) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101058@unknown@formal@none@1@S@SCOPE serves as a proof-of-concept, demonstrating an efficient and effective approach to ensemble-based motif finding.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "serve") (:form . "serves") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "proof-of-concept") (:form . "proof-of-concept")\n  (:end . 34) (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 49)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ensemble-based") (:form . "ensemble-based")\n  (:end . 103) (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 109)\n  (:start . 104) (:id . 56))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 117)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s3.278) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101060@unknown@formal@none@1@S@Its strong performance, rapid runtime and freedom from nuisance parameters make it a simple and effective tool for the biologist.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "runtime") (:form . "runtime") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "freedom") (:form . "freedom") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nuisance") (:form . "nuisance") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "effective") (:form . "effective") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "tool") (:form . "tool") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "biologist") (:form . "biologist") (:end . 128)\n  (:start . 119) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.280) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101061@unknown@formal@none@1@S@Methods@(((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.281) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5101062@unknown@formal@none@1@S@Accuracy, Sensitivity and Positive Predictive Value@(((:tag . "NN") (:stem . "accuracy") (:form . "Accuracy") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "Sensitivity") (:form . "Sensitivity") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "positive") (:form . "Positive") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "JJ") (:stem . "predictive") (:form . "Predictive") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "Value") (:form . "Value") (:end . 51) (:start . 46)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s3.282) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101063@unknown@formal@none@1@S@Each algorithm's accuracy for each regulon was measured via the Phi score (also referred to as nucleotide level performance coefficient, or nPC, in previous performance comparisons 45611.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Phi") (:form . "Phi") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 105)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 111)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "coefficient") (:form . "coefficient") (:end . 135)\n  (:start . 124) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "npc") (:form . "nPC") (:end . 143) (:start . 140)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 156)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 168)\n  (:start . 157) (:id . 70))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 180)\n  (:start . 169) (:id . 71))\n ((:tag . "CD") (:stem . "45611") (:form . "45611") (:end . 186)\n  (:start . 181) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s3.283) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101064@unknown@formal@none@1@S@This metric, first proposed by Pevzner and Sze 29, measures the degree of overlap between the actual instances of two motifs (or sets of motifs) m1 and m2 in the set of co-regulated upstream sequences.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "metric") (:form . "metric") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Pevzner") (:form . "Pevzner") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sze") (:form . "Sze") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "measure") (:form . "measures") (:end . 59)\n  (:start . 51) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 70)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "overlap") (:form . "overlap") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 89)\n  (:start . 82) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 124)\n  (:start . 118) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 143)\n  (:start . 137) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 70))\n ((:tag . "NN") (:stem . "m1") (:form . "m1") (:end . 147) (:start . 145)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 72))\n ((:tag . "NN") (:stem . "m2") (:form . "m2") (:end . 154) (:start . 152)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 75))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 165) (:start . 162)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "co-regulated") (:form . "co-regulated") (:end . 181)\n  (:start . 169) (:id . 78))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 190)\n  (:start . 182) (:id . 79))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 200)\n  (:start . 191) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s3.284) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101065@unknown@formal@none@1@S@The Phi score can be defined as follows: let U be a unique numbering of all the bases in the upstream sequences of a given gene set, and IU(m) ⊆ U be the set of bases that are covered by actual instances of m in U.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Phi") (:form . "Phi") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "VB") (:stem . "let") (:form . "let") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 58)\n  (:start . 52) (:id . 55))\n ((:tag . "NN") (:stem . "numbering") (:form . "numbering") (:end . 68)\n  (:start . 59) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 57))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 75) (:start . 72)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 85) (:start . 80)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 101)\n  (:start . 93) (:id . 63))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 111)\n  (:start . 102) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 122)\n  (:start . 117) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 127) (:start . 123)\n  (:id . 68))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 131) (:start . 128)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "IU(m)") (:form . "IU(m)") (:end . 142)\n  (:start . 137) (:id . 72))\n ((:tag . "NNP") (:stem . "⊆") (:form . "⊆") (:end . 144) (:start . 143)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 146) (:start . 145)\n  (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 76))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 157) (:start . 154)\n  (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 166)\n  (:start . 161) (:id . 79))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 80))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 175) (:start . 172)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 183)\n  (:start . 176) (:id . 82))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 186) (:start . 184)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 193)\n  (:start . 187) (:id . 84))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 203)\n  (:start . 194) (:id . 85))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 206) (:start . 204)\n  (:id . 86))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 208) (:start . 207)\n  (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 211) (:start . 209)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "U") (:form . "U") (:end . 213) (:start . 212)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s3.285) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101066@unknown@formal@none@1@S@Phi is then defined as the ratio of the number of bases occupied by the actual instances of both the motifs, to the total number of bases occupied by the actual instances of either of the two motifs:@(((:tag . "NNP") (:stem . "Phi") (:form . "Phi") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 19)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 46)\n  (:start . 40) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 78)\n  (:start . 72) (:id . 57))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 88)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "PDT") (:stem . "both") (:form . "both") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 107)\n  (:start . 101) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 121)\n  (:start . 116) (:id . 66))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 128)\n  (:start . 122) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 131) (:start . 129)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 137)\n  (:start . 132) (:id . 69))\n ((:tag . "VBN") (:stem . "occupy") (:form . "occupied") (:end . 146)\n  (:start . 138) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 149) (:start . 147)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 160)\n  (:start . 154) (:id . 73))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 170)\n  (:start . 161) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 75))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 180)\n  (:start . 174) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 78))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 191) (:start . 188)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 198)\n  (:start . 192) (:id . 80))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 199) (:start . 198)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s3.286) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101067@unknown@formal@none@1@S@ΦU(m1, m2) = [IU(m1) ∩ IU(m2)]/[IU(m1) ∪ IU(m2)].@(((:tag . "NNP") (:stem . "ΦU(m1") (:form . "ΦU(m1") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "m2") (:form . "m2") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 12) (:start . 11)\n  (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 14) (:start . 13)\n  (:id . 47))\n ((:tag . "FW") (:stem . "IU(m1)") (:form . "IU(m1)") (:end . 20)\n  (:start . 14) (:id . 48))\n ((:tag . "NN") (:stem . "∩") (:form . "∩") (:end . 22) (:start . 21)\n  (:id . 49))\n ((:tag . "FW") (:stem . "IU(m2)]/[IU(m1)") (:form . "IU(m2)]/[IU(m1)")\n  (:end . 38) (:start . 23) (:id . 50))\n ((:tag . "NN") (:stem . "∪") (:form . "∪") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "FW") (:stem . "IU(m2)") (:form . "IU(m2)") (:end . 47)\n  (:start . 41) (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s3.287) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101068@unknown@formal@none@1@S@This metric therefore takes both false positives and false negatives into account at the level of the individual bases that are actually covered by the motif.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "metric") (:form . "metric") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "positive") (:form . "positives") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "negative") (:form . "negatives") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "account") (:form . "account") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 112)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 118)\n  (:start . 113) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "actually") (:form . "actually") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 144)\n  (:start . 137) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s3.288) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101070@unknown@formal@none@1@S@Changing the denominator of the Phi equation to be IU(mi) yields the sensitivity (if mi represents the true binding sites) or the positive predictive value (PPV, if mi represents the reported binding sites).@(((:tag . "VBG") (:stem . "change") (:form . "Changing") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "denominator") (:form . "denominator") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Phi") (:form . "Phi") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "equation") (:form . "equation") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "IU(mi)") (:form . "IU(mi)") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "VBZ") (:stem . "yield") (:form . "yields") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 55))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mi") (:form . "mi") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "true") (:form . "true") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "JJ") (:stem . "predictive") (:form . "predictive") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "PPV") (:form . "PPV") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 164) (:start . 162)\n  (:id . 72))\n ((:tag . "NN") (:stem . "mi") (:form . "mi") (:end . 167) (:start . 165)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 178)\n  (:start . 168) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 191)\n  (:start . 183) (:id . 76))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 199)\n  (:start . 192) (:id . 77))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 205)\n  (:start . 200) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s3.290) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101071@unknown@formal@none@1@S@See Additional file 1, section S3, for a discussion on the use of Phi score for measuring accuracy.@(((:tag . "VB") (:stem . "see") (:form . "See") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "s3") (:form . "S3") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "discussion") (:form . "discussion") (:end . 51)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Phi") (:form . "Phi") (:end . 69) (:start . 66)\n  (:id . 57))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 75) (:start . 70)\n  (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "measure") (:form . "measuring") (:end . 89)\n  (:start . 80) (:id . 60))\n ((:tag . "NN") (:stem . "accuracy") (:form . "accuracy") (:end . 98)\n  (:start . 90) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s3.291) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101072@unknown@formal@none@1@S@Objective functions for Statistical Significance@(((:tag . "JJ") (:stem . "objective") (:form . "Objective") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "statistical") (:form . "Statistical") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "Significance") (:end . 48)\n  (:start . 36) (:id . 46)))@@@1@5@((:identifiers (:sid . :s3.292) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101073@unknown@formal@none@1@S@In line with other motif finders, we have used statistical significance as a surrogate for biological significance.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 58)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 71)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "surrogate") (:form . "surrogate") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 114)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.293) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101074@unknown@formal@none@1@S@Since the latter cannot be defined without data that obviates the need for computational motif finding, objective functions that approximate biological significance are critical.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "obviate") (:form . "obviates") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "need") (:form . "need") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "approximate") (:form . "approximate") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 151)\n  (:start . 141) (:id . 63))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 164)\n  (:start . 152) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 168) (:start . 165)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 177)\n  (:start . 169) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x3.294.1) (:span 35 42)) ((:id . :x3.294.2) (:span 17 23)))\n (:nscopes ((:id . :x3.294.1) (:span 35 102))\n  ((:id . :x3.294.2) (:span 6 102)))\n (:identifiers (:sid . :s3.294) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101075@unknown@formal@none@1@S@In this section, we detail the objective functions we used and their effect on SCOPE's performance.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "detail") (:form . "detail") (:end . 26)\n  (:start . 20) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 40)\n  (:start . 31) (:id . 49))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 68)\n  (:start . 63) (:id . 54))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SCOPE") (:form . "SCOPE") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "performance") (:form . "performance") (:end . 98)\n  (:start . 87) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s3.295) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101076@unknown@formal@none@1@S@For any motif m, each objective function provides a definition for p(m), the probability of observing a motif with the same sufficient statistics as m assuming a particular null model.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 31)\n  (:start . 22) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "definition") (:form . "definition") (:end . 62)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "p(m)") (:form . "p(m)") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 88)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "observe") (:form . "observing") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 134)\n  (:start . 124) (:id . 65))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "assume") (:form . "assuming") (:end . 159)\n  (:start . 151) (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 172)\n  (:start . 162) (:id . 71))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 177) (:start . 173)\n  (:id . 72))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 183)\n  (:start . 178) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s3.296) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101077@unknown@formal@none@1@S@This p-value is used in the computation of the Sig score (see Results).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p-value") (:form . "p-value") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "computation") (:form . "computation") (:end . 39)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sig") (:form . "Sig") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 69)\n  (:start . 62) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.297) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101078@unknown@formal@none@1@S@Overrepresentation@(((:tag . "NNP") (:stem . "Overrepresentation") (:form . "Overrepresentation")\n  (:end . 18) (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.298) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101080@unknown@formal@none@1@S@In the context of consensus motifs, overrepresentation is expressed in terms of a multinomial model, in which each position i in each gene j is a random variable Xij that can take on any motif allowed by the particular motif model.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 54) (:start . 36) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multinomial") (:form . "multinomial") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "i") (:form . "i") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 138) (:start . 134)\n  (:id . 66))\n ((:tag . "NN") (:stem . "j") (:form . "j") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 145) (:start . 144)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 152)\n  (:start . 146) (:id . 70))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 161)\n  (:start . 153) (:id . 71))\n ((:tag . "NNP") (:stem . "Xij") (:form . "Xij") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "VB") (:stem . "take") (:form . "take") (:end . 179) (:start . 175)\n  (:id . 75))\n ((:tag . "RP") (:stem . "on") (:form . "on") (:end . 182) (:start . 180)\n  (:id . 76))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 186) (:start . 183)\n  (:id . 77))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 192)\n  (:start . 187) (:id . 78))\n ((:tag . "VBN") (:stem . "allow") (:form . "allowed") (:end . 200)\n  (:start . 193) (:id . 79))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 218)\n  (:start . 208) (:id . 82))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 224)\n  (:start . 219) (:id . 83))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 230)\n  (:start . 225) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s3.300) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101081@unknown@formal@none@1@S@The probability of seeing m at least C(m) times in the regulon can be approximated by the Poisson distribution: p(m) = ∑k≥C(m) [(λke-λ)/k! ] where λ is the expectation of C(m) with respect to the null motif distribution and the number of positions in the regulon.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "see") (:form . "seeing") (:end . 25) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "C(m)") (:form . "C(m)") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "approximate") (:form . "approximated") (:end . 82)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Poisson") (:form . "Poisson") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 110)\n  (:start . 98) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "p(m)") (:form . "p(m)") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "∑k≥C(m)") (:form . "∑k≥C(m)") (:end . 126)\n  (:start . 119) (:id . 64))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "λke-λ)/k") (:form . "λke-λ)/k") (:end . 137)\n  (:start . 129) (:id . 67))\n ((:tag . ".") (:stem . "!") (:form . "!") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 146)\n  (:start . 141) (:id . 70))\n ((:tag . "NNP") (:stem . "λ") (:form . "λ") (:end . 148) (:start . 147)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 151) (:start . 149)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 73))\n ((:tag . "NN") (:stem . "expectation") (:form . "expectation") (:end . 167)\n  (:start . 156) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 75))\n ((:tag . "NN") (:stem . "C(m)") (:form . "C(m)") (:end . 175) (:start . 171)\n  (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 180) (:start . 176)\n  (:id . 77))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 188)\n  (:start . 181) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 191) (:start . 189)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 195) (:start . 192)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 200) (:start . 196)\n  (:id . 81))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 206)\n  (:start . 201) (:id . 82))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 219)\n  (:start . 207) (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 223) (:start . 220)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 85))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 234)\n  (:start . 228) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 247)\n  (:start . 238) (:id . 88))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 250) (:start . 248)\n  (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 254) (:start . 251)\n  (:id . 90))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 262)\n  (:start . 255) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s3.301) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101082@unknown@formal@none@1@S@A detailed justification of this approach was given by Carlson et al. 11.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "justification") (:form . "justification")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Carlson") (:form . "Carlson") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s3.302) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101083@unknown@formal@none@1@S@The expectation λ is most accurately modeled using Maximum Likelihood Estimators (MLEs) computed as the actual proportion of any given motif in the complete set of all upstream sequences in the genome 10.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expectation") (:form . "expectation") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "λ") (:form . "λ") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "accurately") (:form . "accurately") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBN") (:stem . "model") (:form . "modeled") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "maximum") (:form . "Maximum") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "Likelihood") (:form . "Likelihood") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NNP") (:stem . "Estimator") (:form . "Estimators") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MLE") (:form . "MLEs") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "actual") (:form . "actual") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 121)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 128) (:start . 125)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 176)\n  (:start . 168) (:id . 71))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 186)\n  (:start . 177) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 200)\n  (:start . 194) (:id . 75))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 203) (:start . 201)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s3.303) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101084@unknown@formal@none@1@S@These MLEs are implemented as lookups of exact substrings, which can be performed efficiently using a suffix array data structure 101112.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "MLE") (:form . "MLEs") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "implement") (:form . "implemented") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "lookup") (:form . "lookups") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "substring") (:form . "substrings") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "suffix") (:form . "suffix") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "array") (:form . "array") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 119)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 129)\n  (:start . 120) (:id . 62))\n ((:tag . "CD") (:stem . "101112") (:form . "101112") (:end . 136)\n  (:start . 130) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.304) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101085@unknown@formal@none@1@S@Coverage@(((:tag . "NNP") (:stem . "Coverage") (:form . "Coverage") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s3.305) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101086@unknown@formal@none@1@S@A simple modification to the overrepresentation objective function is coverage, which is identical to overrepresentation with the modification that C(m) is the number of upstream regions in the regulon that have one or more instances of m and λ, the expectation of C(m), is determined from the proportion of upstream regions in the genome that contain the motif.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 47) (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 57)\n  (:start . 48) (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 66)\n  (:start . 58) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 78)\n  (:start . 70) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 120) (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 59))\n ((:tag . "NN") (:stem . "modification") (:form . "modification") (:end . 142)\n  (:start . 130) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "C(m)") (:form . "C(m)") (:end . 152) (:start . 148)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 155) (:start . 153)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 64))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 166)\n  (:start . 160) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 178)\n  (:start . 170) (:id . 67))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 186)\n  (:start . 179) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 70))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 201)\n  (:start . 194) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 206) (:start . 202)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 211) (:start . 207)\n  (:id . 73))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 215) (:start . 212)\n  (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 223) (:start . 219)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 233)\n  (:start . 224) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 236) (:start . 234)\n  (:id . 78))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 238) (:start . 237)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "λ") (:form . "λ") (:end . 244) (:start . 243)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 245) (:start . 244)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 249) (:start . 246)\n  (:id . 83))\n ((:tag . "NN") (:stem . "expectation") (:form . "expectation") (:end . 261)\n  (:start . 250) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 264) (:start . 262)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "C(m)") (:form . "C(m)") (:end . 269) (:start . 265)\n  (:id . 86))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 270) (:start . 269)\n  (:id . 87))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 273) (:start . 271)\n  (:id . 88))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 284)\n  (:start . 274) (:id . 89))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 289) (:start . 285)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 293) (:start . 290)\n  (:id . 91))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 304)\n  (:start . 294) (:id . 92))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 307) (:start . 305)\n  (:id . 93))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 316)\n  (:start . 308) (:id . 94))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 324)\n  (:start . 317) (:id . 95))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 327) (:start . 325)\n  (:id . 96))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 331) (:start . 328)\n  (:id . 97))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 338)\n  (:start . 332) (:id . 98))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 343) (:start . 339)\n  (:id . 99))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 351)\n  (:start . 344) (:id . 100))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 355) (:start . 352)\n  (:id . 101))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 361)\n  (:start . 356) (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 362) (:start . 361)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s3.306) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101087@unknown@formal@none@1@S@While this objective function prevents a single upstream region from dominating a motif's score, it fails to account for multiple instances of a binding site in a single gene that may arise due to cooperative binding.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "objective") (:form . "objective") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "VBZ") (:stem . "prevent") (:form . "prevents") (:end . 38)\n  (:start . 30) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "dominate") (:form . "dominating") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "fail") (:form . "fails") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "VB") (:stem . "account") (:form . "account") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "instance") (:form . "instances") (:end . 139)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 169)\n  (:start . 163) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 174) (:start . 170)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 179) (:start . 175)\n  (:id . 73))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 183) (:start . 180)\n  (:id . 74))\n ((:tag . "VB") (:stem . "arise") (:form . "arise") (:end . 189)\n  (:start . 184) (:id . 75))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 193) (:start . 190)\n  (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 196) (:start . 194)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "cooperative") (:form . "cooperative") (:end . 208)\n  (:start . 197) (:id . 78))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 216)\n  (:start . 209) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x3.307.1) (:span 180 183)))\n (:ncues ((:id . :x3.307.2) (:span 100 105)))\n (:hscopes ((:id . :x3.307.1) (:span 180 216)))\n (:nscopes ((:id . :x3.307.2) (:span 100 216)))\n (:identifiers (:sid . :s3.307) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101088@unknown@formal@none@1@S@Positional bias@(((:tag . "JJ") (:stem . "positional") (:form . "Positional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "bia") (:form . "bias") (:end . 15) (:start . 11)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s3.308) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101090@unknown@formal@none@1@S@One well known example is TBP (TATA-binding protein), which localizes the RNA polymerase complex by binding the TATA-box motif roughly 25 bases upstream of the transcription start site 30.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "tata-binding") (:form . "TATA-binding") (:end . 43)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "localize") (:form . "localizes") (:end . 69)\n  (:start . 60) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 88)\n  (:start . 78) (:id . 57))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "tata-box") (:form . "TATA-box") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "RB") (:stem . "roughly") (:form . "roughly") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 143)\n  (:start . 138) (:id . 66))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 173) (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 179)\n  (:start . 174) (:id . 71))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s3.310) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101091@unknown@formal@none@1@S@While other examples of binding sites with positional restrictions are well known, few motif finders incorporate position in their scoring function.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "positional") (:form . "positional") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "restriction") (:form . "restrictions") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "finder") (:form . "finders") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "JJ") (:stem . "incorporate") (:form . "incorporate") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.311) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101092@unknown@formal@none@1@S@In the case where all upstream regions are the same length, the Kolmogorov-Smirnov (KS) statistic provides a natural test for positional bias.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Kolmogorov-Smirnov") (:form . "Kolmogorov-Smirnov")\n  (:end . 82) (:start . 64) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "statistic") (:form . "statistic") (:end . 97)\n  (:start . 88) (:id . 59))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 106)\n  (:start . 98) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "positional") (:form . "positional") (:end . 136)\n  (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 141) (:start . 137)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s3.312) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101093@unknown@formal@none@1@S@The Kolmogorov-Smirnov (KS) statistic is a non-parametric statistic that measures the probability that two samples are drawn from the same distribution.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Kolmogorov-Smirnov") (:form . "Kolmogorov-Smirnov")\n  (:end . 22) (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "statistic") (:form . "statistic") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "non-parametric") (:form . "non-parametric")\n  (:end . 57) (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "statistic") (:form . "statistic") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "measure") (:form . "measures") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 97)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "draw") (:form . "drawn") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 138) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 151)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s3.313) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101094@unknown@formal@none@1@S@Let X be the sample that we wish to compare to some reference sample Y.@(((:tag . "VB") (:stem . "let") (:form . "Let") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 19)\n  (:start . 13) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "wish") (:form . "wish") (:end . 32) (:start . 28)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 50))\n ((:tag . "VB") (:stem . "compare") (:form . "compare") (:end . 43)\n  (:start . 36) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 52))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 51) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 61)\n  (:start . 52) (:id . 54))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 68)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 70) (:start . 69)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.314) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101095@unknown@formal@none@1@S@The KS statistic is defined to be the maximum absolute difference between the unbiased cumulative distribution functions of X and Y.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "statistic") (:form . "statistic") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "maximum") (:form . "maximum") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "JJ") (:stem . "absolute") (:form . "absolute") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unbiased") (:form . "unbiased") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "JJ") (:stem . "cumulative") (:form . "cumulative") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 110)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 120)\n  (:start . 111) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 125) (:start . 124)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Y") (:form . "Y") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s3.315) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101096@unknown@formal@none@1@S@The KS statistic has a well-defined distribution from which a p-value can be easily computed.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "KS") (:form . "KS") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "statistic") (:form . "statistic") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "well-defined") (:form . "well-defined") (:end . 35)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p-value") (:form . "p-value") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "RB") (:stem . "easily") (:form . "easily") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "VBN") (:stem . "compute") (:form . "computed") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.316) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101097@unknown@formal@none@1@S@Kuiper's variation was used to increase sensitivity in the tails of the distribution 31.@(((:tag . "NNP") (:stem . "Kuiper") (:form . "Kuiper") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "variation") (:form . "variation") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "sensitivity") (:form . "sensitivity") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tail") (:form . "tails") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 84)\n  (:start . 72) (:id . 55))\n ((:tag . "CD") (:stem . "31") (:form . "31") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.317) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101098@unknown@formal@none@1@S@In the context of motifs, we defined the test sample X for a motif m to be the set of starting positions (with respect to transcription start sites) of m in the regulon.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "define") (:form . "defined") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 45) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 52)\n  (:start . 46) (:id . 52))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 66) (:start . 61)\n  (:id . 56))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 60))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 82) (:start . 79)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "start") (:form . "starting") (:end . 94)\n  (:start . 86) (:id . 63))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 104)\n  (:start . 95) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 65))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 110) (:start . 106)\n  (:id . 66))\n ((:tag . "NN") (:stem . "respect") (:form . "respect") (:end . 118)\n  (:start . 111) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 121) (:start . 119)\n  (:id . 68))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 135) (:start . 122) (:id . 69))\n ((:tag . "NN") (:stem . "start") (:form . "start") (:end . 141)\n  (:start . 136) (:id . 70))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 147)\n  (:start . 142) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 73))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 153) (:start . 152)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 76))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 168)\n  (:start . 161) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s3.318) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101100@unknown@formal@none@1@S@Thus, pKS(m) is a measure of how m is localized differently in the regulon than in the genome as a whole.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "pKS(m)") (:form . "pKS(m)") (:end . 12)\n  (:start . 6) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "measure") (:form . "measure") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 47)\n  (:start . 38) (:id . 52))\n ((:tag . "RB") (:stem . "differently") (:form . "differently") (:end . 59)\n  (:start . 48) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "NN") (:stem . "regulon") (:form . "regulon") (:end . 74)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 93)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 62))\n ((:tag . "NN") (:stem . "whole") (:form . "whole") (:end . 104) (:start . 99)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s3.320) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101101@unknown@formal@none@1@S@It is also possible to define Y as the uniform distribution; however, we found that many motifs had non-uniform distributions throughout all upstream regions of the genome, possibly as an artifact of the non-uniform AT/CG distributions in upstream regions 32.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "y") (:form . "Y") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "uniform") (:form . "uniform") (:end . 46)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 59)\n  (:start . 47) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 72) (:start . 70)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 95)\n  (:start . 89) (:id . 60))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "non-uniform") (:form . "non-uniform") (:end . 111)\n  (:start . 100) (:id . 62))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 125) (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 136)\n  (:start . 126) (:id . 64))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 171)\n  (:start . 165) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 184) (:start . 182)\n  (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 187) (:start . 185)\n  (:id . 74))\n ((:tag . "NN") (:stem . "artifact") (:form . "artifact") (:end . 196)\n  (:start . 188) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "non-uniform") (:form . "non-uniform") (:end . 215)\n  (:start . 204) (:id . 78))\n ((:tag . "NN") (:stem . "at/cg") (:form . "AT/CG") (:end . 221)\n  (:start . 216) (:id . 79))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 235) (:start . 222) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 238) (:start . 236)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 247)\n  (:start . 239) (:id . 82))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 255)\n  (:start . 248) (:id . 83))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 258) (:start . 256)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x3.321.1) (:span 173 181))\n  ((:id . :x3.321.2) (:span 11 19)))\n (:hscopes ((:id . :x3.321.1) (:span 173 255))\n  ((:id . :x3.321.2) (:span 11 59)))\n (:identifiers (:sid . :s3.321) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101102@unknown@formal@none@1@S@Combining overrepresentation and positional bias@(((:tag . "VBG") (:stem . "combine") (:form . "Combining") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 28) (:start . 10) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positional") (:form . "positional") (:end . 43)\n  (:start . 33) (:id . 45))\n ((:tag . "NNS") (:stem . "bia") (:form . "bias") (:end . 48) (:start . 44)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s3.322) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101103@unknown@formal@none@1@S@Since overrepresentation and KS are independent, the probabilities can simply be multiplied together to yield the probability of randomly sampling a motif with a given degree of overrepresentation and positional bias.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 24) (:start . 6) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ks") (:form . "KS") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 47)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "probability") (:form . "probabilities") (:end . 66)\n  (:start . 53) (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 77)\n  (:start . 71) (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "multiply") (:form . "multiplied") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 100)\n  (:start . 92) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 103) (:start . 101)\n  (:id . 56))\n ((:tag . "VB") (:stem . "yield") (:form . "yield") (:end . 109)\n  (:start . 104) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 125)\n  (:start . 114) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 137)\n  (:start . 129) (:id . 61))\n ((:tag . "VBG") (:stem . "sample") (:form . "sampling") (:end . 146)\n  (:start . 138) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 63))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 154)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 174)\n  (:start . 168) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 196) (:start . 178) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "positional") (:form . "positional") (:end . 211)\n  (:start . 201) (:id . 72))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 216) (:start . 212)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s3.323) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101104@unknown@formal@none@1@S@Motif orientation@(((:tag . "NN") (:stem . "motif") (:form . "Motif") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 17)\n  (:start . 6) (:id . 43)))@@@1@2@((:identifiers (:sid . :s3.324) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101105@unknown@formal@none@1@S@Many transcription factors will bind motifs on either DNA strand.@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s3.325) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101106@unknown@formal@none@1@S@Others, such as the general transcription factor TBP (TATA-Binding Protein), require a specific orientation and will only function if bound to motifs on a specific DNA strand 30.@(((:tag . "NNS") (:stem . "other") (:form . "Others") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 41) (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "TBP") (:form . "TBP") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TATA-Binding") (:form . "TATA-Binding") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 95)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 107)\n  (:start . 96) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 163)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "strand") (:form . "strand") (:end . 174)\n  (:start . 168) (:id . 72))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s3.326) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101107@unknown@formal@none@1@S@In scoring a motif m, a choice must therefore be made as to whether or not the reverse complement mR of m will be considered to be the same motif as m.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "score") (:form . "scoring") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 48))\n ((:tag . "NN") (:stem . "choice") (:form . "choice") (:end . 30)\n  (:start . 24) (:id . 49))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 35) (:start . 31)\n  (:id . 50))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 45)\n  (:start . 36) (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 67)\n  (:start . 60) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 70) (:start . 68)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 74) (:start . 71)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "reverse") (:form . "reverse") (:end . 86)\n  (:start . 79) (:id . 60))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 97)\n  (:start . 87) (:id . 61))\n ((:tag . "NNP") (:stem . "mR") (:form . "mR") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 63))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 105) (:start . 104)\n  (:id . 64))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 110) (:start . 106)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 113) (:start . 111)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 124)\n  (:start . 114) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 68))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 139) (:start . 135)\n  (:id . 71))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 145)\n  (:start . 140) (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 73))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 150) (:start . 149)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x3.327.1) (:span 114 124))\n  ((:id . :x3.327.2) (:span 60 74)))\n (:hscopes ((:id . :x3.327.1) (:span 75 150))\n  ((:id . :x3.327.2) (:span 60 150)))\n (:identifiers (:sid . :s3.327) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101108@unknown@formal@none@1@S@Most programs assume motif orientation does not matter and so define m = mR.@(((:tag . "JJS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "program") (:form . "programs") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "assume") (:form . "assume") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "matter") (:form . "matter") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "m") (:form . "m") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "mR") (:form . "mR") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:ncues ((:id . :x3.328.1) (:span 44 47)))\n (:nscopes ((:id . :x3.328.1) (:span 44 54)))\n (:identifiers (:sid . :s3.328) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101110@unknown@formal@none@1@S@We thus chose to attach a flag to each motif, indicating whether or not the motif should be orientation-neutral.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "choose") (:form . "chose") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "attach") (:form . "attach") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "flag") (:form . "flag") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 56)\n  (:start . 46) (:id . 53))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 64)\n  (:start . 57) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 81) (:start . 76)\n  (:id . 58))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 88)\n  (:start . 82) (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 91) (:start . 89)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "orientation-neutral")\n  (:form . "orientation-neutral") (:end . 111) (:start . 92) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x3.330.1) (:span 82 88)) ((:id . :x3.330.2) (:span 57 71)))\n (:hscopes ((:id . :x3.330.1) (:span 72 111))\n  ((:id . :x3.330.2) (:span 57 111)))\n (:identifiers (:sid . :s3.330) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101111@unknown@formal@none@1@S@BEAM and SPACER thus enumerate and evaluate all motifs with both values of this flag.@(((:tag . "NN") (:stem . "beam") (:form . "BEAM") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "spacer") (:form . "SPACER") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "enumerate") (:form . "enumerate") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VB") (:stem . "evaluate") (:form . "evaluate") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "flag") (:form . "flag") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s3.331) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101112@unknown@formal@none@1@S@SCOPE reports that orientation does matter (i.e. m ≠ mR) for 17% of the regulons in our biological test set.@(((:tag . "NN") (:stem . "scope") (:form . "SCOPE") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "report") (:form . "reports") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "orientation") (:form . "orientation") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "matter") (:form . "matter") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "FW") (:stem . "m") (:form . "m") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "FW") (:stem . "≠") (:form . "≠") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "mR") (:form . "mR") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 64) (:start . 63)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "regulon") (:form . "regulons") (:end . 80)\n  (:start . 72) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 87) (:start . 84)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "biological") (:form . "biological") (:end . 98)\n  (:start . 88) (:id . 62))\n ((:tag . "NN") (:stem . "test") (:form . "test") (:end . 103) (:start . 99)\n  (:id . 63))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 107) (:start . 104)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s3.332) (:did . :1471-2105-8-249)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101113@unknown@formal@none@1@S@Reuse of structural domain–domain interactions in protein networks@(((:tag . "NNP") (:stem . "Reuse") (:form . "Reuse") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 46)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 57)\n  (:start . 50) (:id . 48))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 66)\n  (:start . 58) (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.1) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5101114@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.2) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101115@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.3) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101116@unknown@formal@none@1@S@Protein interactions are thought to be largely mediated by interactions between structural domains.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 79)\n  (:start . 72) (:id . 52))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 90)\n  (:start . 80) (:id . 53))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 98)\n  (:start . 91) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x4.4.1) (:span 25 32)))\n (:hscopes ((:id . :x4.4.1) (:span 0 98)))\n (:identifiers (:sid . :s4.4) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101117@unknown@formal@none@1@S@Databases such as iPfam relate interactions in protein structures to known domain families.@(((:tag . "NNS") (:stem . "database") (:form . "Databases") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "relate") (:form . "relate") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 81)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.5) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101118@unknown@formal@none@1@S@Here, we investigate how the domain interactions from the iPfam database are distributed in protein interactions taken from the HPRD, MPact, BioGRID, DIP and IntAct databases.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 20)\n  (:start . 9) (:id . 45))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 48)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 72)\n  (:start . 64) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 112)\n  (:start . 100) (:id . 58))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 118)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 123) (:start . 119)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MPact") (:form . "MPact") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BioGRID") (:form . "BioGRID") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "DIP") (:form . "DIP") (:end . 153) (:start . 150)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "IntAct") (:form . "IntAct") (:end . 164)\n  (:start . 158) (:id . 70))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 174)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s4.6) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101120@unknown@formal@none@1@S@We find that known structural domain interactions can only explain a subset of 4–19% of the available protein interactions, nevertheless this fraction is still significantly bigger than expected by chance.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "CD") (:stem . "4–19") (:form . "4–19") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 122)\n  (:start . 110) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "RB") (:stem . "nevertheless") (:form . "nevertheless") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 141) (:start . 137)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 150)\n  (:start . 142) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 159)\n  (:start . 154) (:id . 67))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 173) (:start . 160) (:id . 68))\n ((:tag . "JJR") (:stem . "big") (:form . "bigger") (:end . 180)\n  (:start . 174) (:id . 69))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 185) (:start . 181)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 194)\n  (:start . 186) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 197) (:start . 195)\n  (:id . 72))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 204)\n  (:start . 198) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s4.8) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101121@unknown@formal@none@1@S@There is a correlation between the frequency of a domain interaction and the connectivity of the proteins it occurs in.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 22)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 68)\n  (:start . 57) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "connectivity") (:form . "connectivity") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.9) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101122@unknown@formal@none@1@S@Furthermore, a large proportion of protein interactions can be attributed to a small number of domain interactions.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 73)\n  (:start . 63) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 114)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.10) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101123@unknown@formal@none@1@S@We conclude that many, but not all, domain interactions constitute reusable modules of molecular recognition.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 55)\n  (:start . 43) (:id . 52))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "JJ") (:stem . "reusable") (:form . "reusable") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 108)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.11) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101124@unknown@formal@none@1@S@A substantial proportion of domain interactions are conserved between E. coli, S. cerevisiae and H. sapiens.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "substantial") (:form . "substantial") (:end . 13)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 47)\n  (:start . 35) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.12) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101125@unknown@formal@none@1@S@These domains are related to essential cellular functions, suggesting that many domain interactions were already present in the last universal common ancestor.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 99)\n  (:start . 87) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 104) (:start . 100)\n  (:id . 56))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 112)\n  (:start . 105) (:id . 57))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 120)\n  (:start . 113) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 123) (:start . 121)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "universal") (:form . "universal") (:end . 142)\n  (:start . 133) (:id . 62))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x4.13.1) (:span 59 69)))\n (:hscopes ((:id . :x4.13.1) (:span 59 158)))\n (:identifiers (:sid . :s4.13) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101126@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.14) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101127@unknown@formal@none@1@S@Our results support the concept of domain interactions as reusable, conserved building blocks of protein interactions, but also highlight the limitations currently imposed by the small number of available protein structures.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "concept") (:form . "concept") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "reusable") (:form . "reusable") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "building") (:form . "building") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "block") (:form . "blocks") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 104)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 117)\n  (:start . 105) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "highlight") (:form . "highlight") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "limitation") (:form . "limitations") (:end . 153)\n  (:start . 142) (:id . 64))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . "VBN") (:stem . "impose") (:form . "imposed") (:end . 171)\n  (:start . 164) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 174) (:start . 172)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 184)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 191)\n  (:start . 185) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 204)\n  (:start . 195) (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 212)\n  (:start . 205) (:id . 73))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 223)\n  (:start . 213) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s4.15) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101128@unknown@formal@none@1@S@Background@(((:tag . "NN") (:stem . "background") (:form . "Background") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.16) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5101130@unknown@formal@none@1@S@Such families of related sequence regions, collected in the Pfam database 1, usually constitute structurally and functionally conserved modules.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "collect") (:form . "collected") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 95)\n  (:start . 85) (:id . 57))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 108)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 125)\n  (:start . 113) (:id . 60))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 135)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.18) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101131@unknown@formal@none@1@S@It is assumed that binding interfaces, too, are conserved evolutionary modules that are reused between proteins of different functions and retained during evolution 23.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "assume") (:form . "assumed") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "interface") (:form . "interfaces") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 57)\n  (:start . 48) (:id . 52))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 70)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "reuse") (:form . "reused") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 124)\n  (:start . 115) (:id . 61))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 154)\n  (:start . 148) (:id . 65))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 164)\n  (:start . 155) (:id . 66))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 167) (:start . 165)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x4.19.1) (:span 6 13)))\n (:hscopes ((:id . :x4.19.1) (:span 6 164)))\n (:identifiers (:sid . :s4.19) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101132@unknown@formal@none@1@S@Therefore, domain–domain interactions are often regarded as the currency of protein–protein interactions.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 24) (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 37)\n  (:start . 25) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "regard") (:form . "regarded") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "currency") (:form . "currency") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein–protein") (:form . "protein–protein")\n  (:end . 91) (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 104)\n  (:start . 92) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.20) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101133@unknown@formal@none@1@S@Based on this assumption, Ng et al. described an approach to predict domain–domain interactions using literature curation, evolutionary history and the distribution of domains in protein interactions 4.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ng") (:form . "Ng") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "describe") (:form . "described") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "VB") (:stem . "predict") (:form . "predict") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 82) (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 95)\n  (:start . 83) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 112)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "curation") (:form . "curation") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 135)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "history") (:form . "history") (:end . 143)\n  (:start . 136) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 64))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 164)\n  (:start . 152) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 175)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 186)\n  (:start . 179) (:id . 69))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 199)\n  (:start . 187) (:id . 70))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 201) (:start . 200)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s4.21) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101134@unknown@formal@none@1@S@Wuchty et al. compared the relationship between this set of predicted interacting domain pairs to the domain coocurrence network 5.@(((:tag . "NNP") (:stem . "Wuchty") (:form . "Wuchty") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 88)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "NN") (:stem . "coocurrence") (:form . "coocurrence") (:end . 120)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 130) (:start . 129)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.22) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101135@unknown@formal@none@1@S@More recently, other groups have come up with sophisticated statistical methods to estimate putatively interacting domain pairs, based on the assumption of domain reusability 678910.@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "come") (:form . "come") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sophisticated") (:form . "sophisticated")\n  (:end . 59) (:start . 46) (:id . 51))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 79)\n  (:start . 72) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "RB") (:stem . "putatively") (:form . "putatively") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 114)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 121)\n  (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 127)\n  (:start . 122) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 134)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 137) (:start . 135)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "reusability") (:form . "reusability") (:end . 174)\n  (:start . 163) (:id . 67))\n ((:tag . "CD") (:stem . "678910") (:form . "678910") (:end . 181)\n  (:start . 175) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x4.23.1) (:span 142 152)) ((:id . :x4.23.2) (:span 92 102)))\n (:hscopes ((:id . :x4.23.1) (:span 142 174))\n  ((:id . :x4.23.2) (:span 92 127)))\n (:identifiers (:sid . :s4.23) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101136@unknown@formal@none@1@S@However, none of these approaches offers structural evidence that the predicted domain pairs are able to form an interaction.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . "VBZ") (:stem . "offer") (:form . "offers") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 124)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x4.24.1) (:span 9 13)))\n (:nscopes ((:id . :x4.24.1) (:span 9 124)))\n (:identifiers (:sid . :s4.24) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101137@unknown@formal@none@1@S@For complexes with known structure, it has been shown that domains can mediate interactions 1112.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 91)\n  (:start . 79) (:id . 56))\n ((:tag . "CD") (:stem . "1112") (:form . "1112") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.25) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101138@unknown@formal@none@1@S@Such interactions between pairs of domains are stored in the iPfam database 13.@(((:tag . "JJ") (:stem . "such") (:form . "Such") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "store") (:form . "stored") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.26) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101140@unknown@formal@none@1@S@Unfortunately, the selection of complexes in the PDB database of protein structures 14 is rather small and biased 15.@(((:tag . "RB") (:stem . "unfortunately") (:form . "Unfortunately")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "biased") (:form . "biased") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.28) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101141@unknown@formal@none@1@S@There is often only a single structure that shows a certain protein pair to interact, while other complexes like haemoglobin have been crystalized dozens of times.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 84)\n  (:start . 76) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 107)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "haemoglobin") (:form . "haemoglobin") (:end . 124)\n  (:start . 113) (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 129) (:start . 125)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "crystalize") (:form . "crystalized") (:end . 146)\n  (:start . 135) (:id . 65))\n ((:tag . "NNS") (:stem . "dozen") (:form . "dozens") (:end . 153)\n  (:start . 147) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.29) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101142@unknown@formal@none@1@S@This makes it difficult to assess whether some domain pairs act as reusable modules in protein interactions from PDB data alone.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "make") (:form . "makes") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "assess") (:form . "assess") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "reusable") (:form . "reusable") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 94)\n  (:start . 87) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 107)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 121)\n  (:start . 117) (:id . 61))\n ((:tag . "RB") (:stem . "alone") (:form . "alone") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x4.30.1) (:span 34 41)))\n (:hscopes ((:id . :x4.30.1) (:span 34 127)))\n (:identifiers (:sid . :s4.30) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101143@unknown@formal@none@1@S@High-throughput experiments 161718 and extensive literature curation efforts 19 have yielded large databases of protein interactions 2021222324.@(((:tag . "JJ") (:stem . "high-throughput") (:form . "High-throughput")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 43))\n ((:tag . "CD") (:stem . "161718") (:form . "161718") (:end . 34)\n  (:start . 28) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 48)\n  (:start . 39) (:id . 46))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 59)\n  (:start . 49) (:id . 47))\n ((:tag . "NN") (:stem . "curation") (:form . "curation") (:end . 68)\n  (:start . 60) (:id . 48))\n ((:tag . "NNS") (:stem . "effort") (:form . "efforts") (:end . 76)\n  (:start . 69) (:id . 49))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 79) (:start . 77)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 84) (:start . 80)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "yield") (:form . "yielded") (:end . 92)\n  (:start . 85) (:id . 52))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 98) (:start . 93)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 108)\n  (:start . 99) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 119)\n  (:start . 112) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 132)\n  (:start . 120) (:id . 57))\n ((:tag . "CD") (:stem . "2021222324") (:form . "2021222324") (:end . 143)\n  (:start . 133) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.31) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101144@unknown@formal@none@1@S@Despite the continuing growth of protein interaction databases, even the best studied protein interaction network of S. cerevisiae is thought to be incomplete and inaccurate 252627.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "continue") (:form . "continuing") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 52)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 105)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 130)\n  (:start . 120) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 133) (:start . 131)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 158)\n  (:start . 148) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "inaccurate") (:form . "inaccurate") (:end . 173)\n  (:start . 163) (:id . 67))\n ((:tag . "CD") (:stem . "252627") (:form . "252627") (:end . 180)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x4.32.1) (:span 134 141)))\n (:hscopes ((:id . :x4.32.1) (:span 69 173)))\n (:identifiers (:sid . :s4.32) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101145@unknown@formal@none@1@S@Given that this network already comprises around 60000 interactions, questions arise as to how such networks have evolved and how they are organised.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "comprise") (:form . "comprises") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "around") (:form . "around") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "CD") (:stem . "60000") (:form . "60000") (:end . 54) (:start . 49)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 67)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "question") (:form . "questions") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "VBP") (:stem . "arise") (:form . "arise") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 87) (:start . 85)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 108)\n  (:start . 100) (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "organise") (:form . "organised") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.33) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101146@unknown@formal@none@1@S@Furthermore, methods for assessing the quality of high-throughput experimental results are in high demand due to the error prone nature of the methods used.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "assess") (:form . "assessing") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 65) (:start . 50) (:id . 50))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 78)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 86)\n  (:start . 79) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 98) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "demand") (:form . "demand") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "prone") (:form . "prone") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 150)\n  (:start . 143) (:id . 65))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 155) (:start . 151)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s4.34) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101147@unknown@formal@none@1@S@In this study, we investigate how pairs of protein families taken from iPfam are distributed in experimental protein interactions from five major model species.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "investigate") (:form . "investigate") (:end . 29)\n  (:start . 18) (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 92)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 108)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 129)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 62))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 139) (:start . 135)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 159)\n  (:start . 152) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s4.35) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101148@unknown@formal@none@1@S@This allows us to address a number of questions:: what proportion of each organism's protein interaction network, its interactome, can be attributed to a known domain–domain interaction?@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "address") (:form . "address") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "question") (:form . "questions") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 49) (:start . 48)\n  (:id . 52))\n ((:tag . "WP") (:stem . "what") (:form . "what") (:end . 54) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 65)\n  (:start . 55) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 55))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 104)\n  (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 129)\n  (:start . 118) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 148)\n  (:start . 138) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 159)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 173) (:start . 160) (:id . 72))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 185)\n  (:start . 174) (:id . 73))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x4.36.1) (:span 18 47)))\n (:hscopes ((:id . :x4.36.1) (:span 18 185)))\n (:identifiers (:sid . :s4.36) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101150@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.38) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5101151@unknown@formal@none@1@S@iPfam domain pairs are overrepresented in experimental protein interactions@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "overrepresente") (:form . "overrepresented")\n  (:end . 38) (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 75)\n  (:start . 63) (:id . 50)))@@@1@9@((:identifiers (:sid . :s4.39) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101152@unknown@formal@none@1@S@We analysed the distribution of Pfam families known to interact from a PDB structure (iPfam domain pairs) in experimentally derived protein interactions (experimental interactions).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyse") (:form . "analysed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 123) (:start . 109) (:id . 62))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 131)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 152)\n  (:start . 140) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 166)\n  (:start . 154) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 179)\n  (:start . 167) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s4.40) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101153@unknown@formal@none@1@S@The experimental interactions were filtered to only include interactions with exactly two partners (see Methods).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 29)\n  (:start . 17) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 43)\n  (:start . 35) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "VB") (:stem . "include") (:form . "include") (:end . 59)\n  (:start . 52) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 72)\n  (:start . 60) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 51))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 89) (:start . 86)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 98)\n  (:start . 90) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 111)\n  (:start . 104) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.41) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101154@unknown@formal@none@1@S@The fraction of experimental interactions that contain at least one iPfam domain pair is referred to as the iPfam coverage.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.42) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101155@unknown@formal@none@1@S@Accordingly, the fraction of experimental interactions that contains any pair of Pfam domains (excluding the iPfam domain pairs) is called the Pfam coverage.@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 41)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 54)\n  (:start . 42) (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 72) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 121)\n  (:start . 115) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 127)\n  (:start . 122) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 131) (:start . 129)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 138)\n  (:start . 132) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s4.43) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101156@unknown@formal@none@1@S@Figure 1 shows the Pfam and iPfam coverage for the analysed species as a column chart.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "chart") (:form . "chart") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.44) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101157@unknown@formal@none@1@S@The number of resolved protein interactions varies greatly between species, as does the size of the underlying proteome (see Table 1).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "resolve") (:form . "resolved") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 43)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "vary") (:form . "varies") (:end . 50) (:start . 44)\n  (:id . 48))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.45) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101158@unknown@formal@none@1@S@The Pfam coverage, coloured red in Figure 1, lies between 49.46% and 66.73%.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "colour") (:form . "coloured") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "lie") (:form . "lies") (:end . 49) (:start . 45)\n  (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 57)\n  (:start . 50) (:id . 53))\n ((:tag . "CD") (:stem . "49.46") (:form . "49.46") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "CD") (:stem . "66.73") (:form . "66.73") (:end . 74) (:start . 69)\n  (:id . 57))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 75) (:start . 74)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.46) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101160@unknown@formal@none@1@S@The iPfam coverage, shown in blue, is much smaller, ranging from 2.92% in D. melanogaster to 19.02% in H. sapiens.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "blue") (:form . "blue") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 50)\n  (:start . 43) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 59)\n  (:start . 52) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 64) (:start . 60)\n  (:id . 55))\n ((:tag . "CD") (:stem . "2.92") (:form . "2.92") (:end . 69) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 70) (:start . 69)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 76) (:start . 74)\n  (:id . 59))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 89)\n  (:start . 77) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . "CD") (:stem . "19.02") (:form . "19.02") (:end . 98) (:start . 93)\n  (:id . 62))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 99) (:start . 98)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 105) (:start . 103)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 113)\n  (:start . 106) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s4.48) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101161@unknown@formal@none@1@S@In S. cerevisiae the species with the most comprehensively studied interactome, the iPfam coverage is 4.47%.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "comprehensively") (:form . "comprehensively")\n  (:end . 58) (:start . 43) (:id . 50))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 78)\n  (:start . 67) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 98)\n  (:start . 90) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 57))\n ((:tag . "CD") (:stem . "4.47") (:form . "4.47") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.49) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101162@unknown@formal@none@1@S@Comparison of coverage of iPfam domain pairs on protein interactions@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 68)\n  (:start . 56) (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.50) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101163@unknown@formal@none@1@S@Comparison of coverage of iPfam domain pairs on protein interactions.@(((:tag . "NN") (:stem . "comparison") (:form . "Comparison") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.51) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101164@unknown@formal@none@1@S@For each species, the height of the column reflects the number of known protein–protein interactions in the data set.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "height") (:form . "height") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 62)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein–protein") (:form . "protein–protein")\n  (:end . 87) (:start . 72) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 112)\n  (:start . 108) (:id . 60))\n ((:tag . "VBN") (:stem . "set") (:form . "set") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.52) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101165@unknown@formal@none@1@S@The columns are split according to the proportion of interactions that contain an iPfam domain pair (blue), that contain any other Pfam domains on both proteins (red), and those that contain no Pfam domain pair (yellow).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "column") (:form . "columns") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "split") (:form . "split") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 94)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 99) (:start . 95)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 130)\n  (:start . 125) (:id . 65))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 143)\n  (:start . 136) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 151) (:start . 147)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 160)\n  (:start . 152) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 75))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 177)\n  (:start . 172) (:id . 76))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 182) (:start . 178)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 190)\n  (:start . 183) (:id . 78))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 193) (:start . 191)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 198) (:start . 194)\n  (:id . 80))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 205)\n  (:start . 199) (:id . 81))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 210) (:start . 206)\n  (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 212) (:start . 211)\n  (:id . 83))\n ((:tag . "NN") (:stem . "yellow") (:form . "yellow") (:end . 218)\n  (:start . 212) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 219) (:start . 218)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x4.53.1) (:span 191 193)))\n (:nscopes ((:id . :x4.53.1) (:span 191 210)))\n (:identifiers (:sid . :s4.53) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101166@unknown@formal@none@1@S@iPfam domain pair coverage on protein interactions@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 50)\n  (:start . 38) (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.54) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5101167@unknown@formal@none@1@S@For each species, we list the size of the proteome as defined in Integr8 and the fraction of this proteome that is represented in the protein interaction sets, followed by the total number of binary protein interactions and the fraction of those that contain an iPfam domain pair.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "list") (:form . "list") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 51))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 50)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 61)\n  (:start . 54) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "integr8") (:form . "Integr8") (:end . 72)\n  (:start . 65) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 58))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 89)\n  (:start . 81) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 97) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 106)\n  (:start . 98) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 126)\n  (:start . 115) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 141)\n  (:start . 134) (:id . 68))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 153)\n  (:start . 142) (:id . 69))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 158) (:start . 154)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 168)\n  (:start . 160) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 171) (:start . 169)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 181)\n  (:start . 176) (:id . 75))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 188)\n  (:start . 182) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 198)\n  (:start . 192) (:id . 78))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 206)\n  (:start . 199) (:id . 79))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 219)\n  (:start . 207) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 223) (:start . 220)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 82))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 236)\n  (:start . 228) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 84))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 245)\n  (:start . 240) (:id . 85))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 250) (:start . 246)\n  (:id . 86))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 258)\n  (:start . 251) (:id . 87))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 261) (:start . 259)\n  (:id . 88))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 267)\n  (:start . 262) (:id . 89))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 274)\n  (:start . 268) (:id . 90))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 279) (:start . 275)\n  (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s4.55) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101168@unknown@formal@none@1@S@The last two columns show the results of the network shuffling experiments.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "column") (:form . "columns") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "shuffling") (:form . "shuffling") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 74)\n  (:start . 63) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.56) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101170@unknown@formal@none@1@S@However, the fact that only a small fraction of protein interactions contain known domain pairs could be a result of the scarcity of available structures of protein complexes.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 68)\n  (:start . 56) (:id . 53))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 95) (:start . 90)\n  (:id . 57))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "scarcity") (:form . "scarcity") (:end . 129)\n  (:start . 121) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 153)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 69))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 174)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x4.58.1) (:span 96 101)))\n (:hscopes ((:id . :x4.58.1) (:span 96 174)))\n (:identifiers (:sid . :s4.58) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101171@unknown@formal@none@1@S@Therefore, we asked whether the observed iPfam coverage is larger than would be expected by chance.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "ask") (:form . "asked") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x4.59.1) (:span 80 88)) ((:id . :x4.59.2) (:span 71 76))\n  ((:id . :x4.59.3) (:span 20 27)))\n (:hscopes ((:id . :x4.59.1) (:span 80 98)) ((:id . :x4.59.2) (:span 71 98))\n  ((:id . :x4.59.3) (:span 20 98)))\n (:identifiers (:sid . :s4.59) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101172@unknown@formal@none@1@S@To test this, we created 1000 random networks per species using the algorithm described in Methods.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "create") (:form . "created") (:end . 24)\n  (:start . 17) (:id . 47))\n ((:tag . "CD") (:stem . "1000") (:form . "1000") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 36)\n  (:start . 30) (:id . 49))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 57)\n  (:start . 50) (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Method") (:form . "Methods") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.60) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101173@unknown@formal@none@1@S@We then calculated the iPfam coverage on the protein interactions in each randomised network.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "calculate") (:form . "calculated") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "randomise") (:form . "randomised") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.61) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101174@unknown@formal@none@1@S@Mean and standard deviations of the randomisation experiments are shown in Table 1.@(((:tag . "JJ") (:stem . "mean") (:form . "Mean") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "deviation") (:form . "deviations") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "randomisation") (:form . "randomisation")\n  (:end . 49) (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 83) (:start . 82)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.62) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101175@unknown@formal@none@1@S@No P value (see Methods) was greater than 1.84 · 10-06.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Method") (:form . "Methods") (:end . 23)\n  (:start . 16) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 36)\n  (:start . 29) (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 41) (:start . 37)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1.84") (:form . "1.84") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "·") (:form . "·") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "CD") (:stem . "10-06") (:form . "10-06") (:end . 54) (:start . 49)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x4.63.1) (:span 0 2)))\n (:nscopes ((:id . :x4.63.1) (:span 0 46)))\n (:identifiers (:sid . :s4.63) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101176@unknown@formal@none@1@S@This proves that the observed iPfam coverage is significantly higher than expected and iPfam domain pairs are enriched in real experimental protein interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "prove") (:form . "proves") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 61) (:start . 48) (:id . 50))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 68) (:start . 62)\n  (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 82)\n  (:start . 74) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 118)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "real") (:form . "real") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 160)\n  (:start . 148) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.64) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101177@unknown@formal@none@1@S@Few iPfam domain pairs are responsible for a majority of the coverage@(((:tag . "JJ") (:stem . "few") (:form . "Few") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 69)\n  (:start . 61) (:id . 53)))@@@1@12@((:identifiers (:sid . :s4.65) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101178@unknown@formal@none@1@S@To understand why iPfam domain pairs occur more often in experimental interactions than expected by chance, we analysed the two largest data sets, S. cerevisiae and H. sapiens in more detail.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "understand") (:form . "understand") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 69)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 82)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "analyse") (:form . "analysed") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "JJS") (:stem . "large") (:form . "largest") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 140)\n  (:start . 136) (:id . 64))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 66))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 160)\n  (:start . 150) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 167) (:start . 165)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 175)\n  (:start . 168) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "NN") (:stem . "detail") (:form . "detail") (:end . 190)\n  (:start . 184) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s4.66) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101180@unknown@formal@none@1@S@In Figure 2, we compare the distribution of iPfam domain pairs on the number of experimental interactions for E. coli, S. cerevisiae and H. sapiens.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "compare") (:form . "compare") (:end . 23)\n  (:start . 16) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 40)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 76)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 92)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 132)\n  (:start . 122) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.68) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101181@unknown@formal@none@1@S@This plot reflects how many iPfam domain pairs cover how many experimental interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "plot") (:form . "plot") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "cover") (:form . "cover") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 87)\n  (:start . 75) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.69) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101182@unknown@formal@none@1@S@Domain pairs that cluster to the left of the plot can be called specific domain pairs, as they only occur in very few covered experimental interactions.@(((:tag . "NN") (:stem . "domain") (:form . "Domain") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "cluster") (:form . "cluster") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "left") (:form . "left") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "plot") (:form . "plot") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 63) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 72)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 94) (:start . 90)\n  (:id . 60))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 99) (:start . 95)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 105)\n  (:start . 100) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 113) (:start . 109)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 117) (:start . 114)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 125)\n  (:start . 118) (:id . 66))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 138)\n  (:start . 126) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 151)\n  (:start . 139) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.70) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101183@unknown@formal@none@1@S@Conversely, domain pairs that cluster to the right of the plot occur in a large number of different covered experimental interactions and can be called promiscuous domain pairs.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "cluster") (:form . "cluster") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "right") (:form . "right") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "plot") (:form . "plot") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 99)\n  (:start . 90) (:id . 60))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 107)\n  (:start . 100) (:id . 61))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 120)\n  (:start . 108) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 133)\n  (:start . 121) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 141) (:start . 138)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 151)\n  (:start . 145) (:id . 67))\n ((:tag . "JJ") (:stem . "promiscuous") (:form . "promiscuous") (:end . 163)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 170)\n  (:start . 164) (:id . 69))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 176)\n  (:start . 171) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s4.71) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101184@unknown@formal@none@1@S@Frequencies of iPfam domain pairs in E. coli, S. cerevisiae and H. sapiens protein interactions@(((:tag . "NNS") (:stem . "frequency") (:form . "Frequencies") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 95)\n  (:start . 83) (:id . 57)))@@@1@16@((:identifiers (:sid . :s4.72) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101185@unknown@formal@none@1@S@Frequencies of iPfam domain pairs in E. coli, S. cerevisiae and H. sapiens protein interactions.@(((:tag . "NNS") (:stem . "frequency") (:form . "Frequencies") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 59)\n  (:start . 49) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 74)\n  (:start . 67) (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 95)\n  (:start . 83) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.73) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101186@unknown@formal@none@1@S@Each point in this graph represents a set of protein interactions.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "graph") (:form . "graph") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s4.74) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101187@unknown@formal@none@1@S@The abscissa reflects the number of interactions in each set that contain the same iPfam domain pair.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "abscissa") (:form . "abscissa") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.75) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101188@unknown@formal@none@1@S@The ordinate shows the number of distinct such sets, each defined by a different iPfam domain pair.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ordinate") (:form . "ordinate") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 65)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.76) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101190@unknown@formal@none@1@S@Dotted lines denote fitted monomial functions, showing that the distributions follow a power law.@(((:tag . "JJ") (:stem . "dotted") (:form . "Dotted") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "fit") (:form . "fitted") (:end . 26) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "monomial") (:form . "monomial") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "law") (:form . "law") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s4.78) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101191@unknown@formal@none@1@S@All three distributions in Figure 2 resemble a power law distribution, according to the good fit of log-linear functions (log(f(x)) = k log x + log a) shown as dotted lines.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "resemble") (:form . "resemble") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "law") (:form . "law") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 69)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "good") (:form . "good") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "fit") (:form . "fit") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "log-linear") (:form . "log-linear") (:end . 110)\n  (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "CD") (:stem . "log(f(x))") (:form . "log(f(x))") (:end . 131)\n  (:start . 122) (:id . 63))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "NN") (:stem . "k") (:form . "k") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "log") (:form . "log") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "SYM") (:stem . "x") (:form . "x") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "NN") (:stem . "log") (:form . "log") (:end . 147) (:start . 144)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 156)\n  (:start . 151) (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 159) (:start . 157)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "dot") (:form . "dotted") (:end . 166)\n  (:start . 160) (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 172)\n  (:start . 167) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s4.79) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101192@unknown@formal@none@1@S@The slopes k of the H. sapiens and S. cerevisiae distributions are very similar (-1.53 and -1.60, respectively), while E. coli has a markedly smaller slope (-2.78).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "slope") (:form . "slopes") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "k") (:form . "k") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 48)\n  (:start . 38) (:id . 51))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 62) (:start . 49) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CD") (:stem . "-1.53") (:form . "-1.53") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "-1.60") (:form . "-1.60") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 110)\n  (:start . 98) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 118)\n  (:start . 113) (:id . 64))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 121) (:start . 119)\n  (:id . 65))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 126) (:start . 122)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 68))\n ((:tag . "RB") (:stem . "markedly") (:form . "markedly") (:end . 141)\n  (:start . 133) (:id . 69))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 149)\n  (:start . 142) (:id . 70))\n ((:tag . "NN") (:stem . "slope") (:form . "slope") (:end . 155)\n  (:start . 150) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 72))\n ((:tag . "CD") (:stem . "-2.78") (:form . "-2.78") (:end . 162)\n  (:start . 157) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s4.80) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101193@unknown@formal@none@1@S@This suggests that the ratio of specific to promiscuous iPfam domain pairs is very similar in S. cerevisiae and H. sapiens, whereas E. coli features fewer multiply reoccurring iPfam domain pairs.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ratio") (:form . "ratio") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "promiscuous") (:form . "promiscuous") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 74) (:start . 69)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 122)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 139) (:start . 135)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "feature") (:form . "features") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 154) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "multiply") (:form . "multiply") (:end . 163)\n  (:start . 155) (:id . 69))\n ((:tag . "VBG") (:stem . "reoccurre") (:form . "reoccurring") (:end . 175)\n  (:start . 164) (:id . 70))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 181)\n  (:start . 176) (:id . 71))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 188)\n  (:start . 182) (:id . 72))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x4.81.1) (:span 5 13)))\n (:hscopes ((:id . :x4.81.1) (:span 5 194)))\n (:identifiers (:sid . :s4.81) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101194@unknown@formal@none@1@S@The power law distribution of iPfam frequencies implies that the majority of covered protein interactions can be attributed to a minority of iPfam domain pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "law") (:form . "law") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "frequency") (:form . "frequencies") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 105)\n  (:start . 93) (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 123)\n  (:start . 113) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "NN") (:stem . "minority") (:form . "minority") (:end . 137)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 146)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 159)\n  (:start . 154) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x4.82.1) (:span 106 109)) ((:id . :x4.82.2) (:span 48 55)))\n (:hscopes ((:id . :x4.82.1) (:span 106 159))\n  ((:id . :x4.82.2) (:span 48 159)))\n (:identifiers (:sid . :s4.82) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101195@unknown@formal@none@1@S@51.7% of the iPfam domain pairs in S. cerevisiae and 45.3% in H. sapiens are seen in just one experimental interaction.@(((:tag . "CD") (:stem . "51.7") (:form . "51.7") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 18) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 25)\n  (:start . 19) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 48)\n  (:start . 38) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "CD") (:stem . "45.3") (:form . "45.3") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 64) (:start . 62)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 72)\n  (:start . 65) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 81) (:start . 77)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 60))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 89) (:start . 85)\n  (:id . 61))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 93) (:start . 90)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 106)\n  (:start . 94) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 118)\n  (:start . 107) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.83) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101196@unknown@formal@none@1@S@Conversely, 92.4% of H. sapiens and 85.4% of S. cerevisiae covered experimental interactions contain an iPfam domain pair that occurs more than once.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "CD") (:stem . "92.4") (:form . "92.4") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "CD") (:stem . "85.4") (:form . "85.4") (:end . 40) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 41) (:start . 40)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 52))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 47) (:start . 45)\n  (:id . 53))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 58)\n  (:start . 48) (:id . 54))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 66)\n  (:start . 59) (:id . 55))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 79)\n  (:start . 67) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 92)\n  (:start . 80) (:id . 57))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 138) (:start . 134)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "RB") (:stem . "once") (:form . "once") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s4.84) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101197@unknown@formal@none@1@S@Even more, half of the covered experimental interactions in H. sapiens contain an iPfam domain pair that occurs in more than 16 different experimental interactions (5 for S. cerevisiae).@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "half") (:form . "half") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 43)\n  (:start . 31) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 56)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 119) (:start . 115)\n  (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 137)\n  (:start . 128) (:id . 65))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 150)\n  (:start . 138) (:id . 66))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 163)\n  (:start . 151) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 170) (:start . 167)\n  (:id . 70))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 184)\n  (:start . 174) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s4.85) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101198@unknown@formal@none@1@S@Degree distribution and iPfam domain pair frequency are correlated@(((:tag . "NN") (:stem . "degree") (:form . "Degree") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "correlate") (:form . "correlated") (:end . 66)\n  (:start . 56) (:id . 50)))@@@1@9@((:identifiers (:sid . :s4.86) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101200@unknown@formal@none@1@S@For each node (i.e. protein) in the filtered H. sapiens and S. cerevisiae protein interaction network, we calculated its degree, defined as the number of adjacent edges (i.e. interactions).@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 44)\n  (:start . 36) (:id . 51))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 55)\n  (:start . 48) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 62) (:start . 60)\n  (:id . 55))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 73)\n  (:start . 63) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 93)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "calculate") (:form . "calculated") (:end . 116)\n  (:start . 106) (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 136)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 150)\n  (:start . 144) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 162)\n  (:start . 154) (:id . 71))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 168)\n  (:start . 163) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 73))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 174) (:start . 170)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 187)\n  (:start . 175) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s4.88) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101201@unknown@formal@none@1@S@At the same time, we counted the number of iPfam domain pairs on the adjacent edges.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "count") (:form . "counted") (:end . 28)\n  (:start . 21) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 48) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 77)\n  (:start . 69) (:id . 57))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.89) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101202@unknown@formal@none@1@S@In Figure 3, we plot the mean number of iPfam domain pairs relative to the degree of the node.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "plot") (:form . "plot") (:end . 20) (:start . 16)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 29) (:start . 25)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 36)\n  (:start . 30) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 45) (:start . 40)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 58) (:start . 53)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 67)\n  (:start . 59) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 57))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 81)\n  (:start . 75) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 93) (:start . 89)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 94) (:start . 93)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.90) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101203@unknown@formal@none@1@S@Average frequency of iPfam domain pairs relative to degree of node@(((:tag . "JJ") (:stem . "average") (:form . "Average") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 66) (:start . 62)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.91) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101204@unknown@formal@none@1@S@Average frequency of iPfam domain pairs relative to degree of node.@(((:tag . "JJ") (:stem . "average") (:form . "Average") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s4.92) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101205@unknown@formal@none@1@S@Each point represents a protein in the interaction networks of H. sapiens (blue) and S. cerevisiae (green).@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.93) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101206@unknown@formal@none@1@S@For each protein, we calculate the degree, defined as the number of interactions the protein is involved in.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "calculate") (:form . "calculate") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 80)\n  (:start . 68) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 92)\n  (:start . 85) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.94) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101207@unknown@formal@none@1@S@On the y-axis, we show the average number of iPfam domain pairs in edges adjacent to proteins of degree x.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 34)\n  (:start . 27) (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 41)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 81)\n  (:start . 73) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 103)\n  (:start . 97) (:id . 61))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.95) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101208@unknown@formal@none@1@S@We calculated a Spearman correlation of 0.68 and 0.71, for H. sapiens and S. cerevisiae.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "calculate") (:form . "calculated") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Spearman") (:form . "Spearman") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "CD") (:stem . "0.68") (:form . "0.68") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "CD") (:stem . "0.71") (:form . "0.71") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 87)\n  (:start . 77) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.96) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101210@unknown@formal@none@1@S@We find that for proteins from a degree of 1 to 50, there is strong correlation in both H. sapiens and S. cerevisiae (Spearman correlation coefficients of 0.68 and 0.71, respectively) between degree and number of iPfam domain pairs on adjacent edges.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 50) (:start . 48)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 54))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 57) (:start . 52)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 67)\n  (:start . 61) (:id . 57))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 79)\n  (:start . 68) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 87) (:start . 83)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 90) (:start . 88)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 98)\n  (:start . 91) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 63))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 105) (:start . 103)\n  (:id . 64))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 116)\n  (:start . 106) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Spearman") (:form . "Spearman") (:end . 126)\n  (:start . 118) (:id . 67))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 138)\n  (:start . 127) (:id . 68))\n ((:tag . "NNS") (:stem . "coefficient") (:form . "coefficients") (:end . 151)\n  (:start . 139) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . "CD") (:stem . "0.68") (:form . "0.68") (:end . 159) (:start . 155)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 72))\n ((:tag . "CD") (:stem . "0.71") (:form . "0.71") (:end . 168) (:start . 164)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 74))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 182)\n  (:start . 170) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 76))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 191)\n  (:start . 184) (:id . 77))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 198)\n  (:start . 192) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 79))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 209)\n  (:start . 203) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 212) (:start . 210)\n  (:id . 81))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 218)\n  (:start . 213) (:id . 82))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 225)\n  (:start . 219) (:id . 83))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 231)\n  (:start . 226) (:id . 84))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 234) (:start . 232)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "adjacent") (:form . "adjacent") (:end . 243)\n  (:start . 235) (:id . 86))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 249)\n  (:start . 244) (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s4.98) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101211@unknown@formal@none@1@S@For the 1.2% of proteins in H. sapiens and 6.4% in S. cerevisiae which have a degree higher than 50, the correlation gradually diminishes.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1.2") (:form . "1.2") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 38)\n  (:start . 31) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "CD") (:stem . "6.4") (:form . "6.4") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 47) (:start . 46)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 53) (:start . 51)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 64)\n  (:start . 54) (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 75) (:start . 71)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 59))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 84)\n  (:start . 78) (:id . 60))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 91) (:start . 85)\n  (:id . 61))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 62))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 99) (:start . 97)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 65))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 116)\n  (:start . 105) (:id . 66))\n ((:tag . "RB") (:stem . "gradually") (:form . "gradually") (:end . 126)\n  (:start . 117) (:id . 67))\n ((:tag . "VBZ") (:stem . "diminish") (:form . "diminishes") (:end . 137)\n  (:start . 127) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.99) (:did . :1471-2105-8-259) (:did-type . :bmc_id)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101212@unknown@formal@none@1@S@Promiscuous domain pairs@(((:tag . "JJ") (:stem . "promiscuous") (:form . "Promiscuous") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 24) (:start . 19)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s4.100) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101213@unknown@formal@none@1@S@Additional file 1 contains a list of all iPfam domain pairs and their frequencies in the experimental protein interactions, while Additional file 4 lists the frequencies of the single domains.@(((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 69)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "frequency") (:form . "frequencies") (:end . 81)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 101)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 122)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 129)\n  (:start . 124) (:id . 62))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "list") (:form . "lists") (:end . 153)\n  (:start . 148) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "frequency") (:form . "frequencies") (:end . 169)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 183)\n  (:start . 177) (:id . 71))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 191)\n  (:start . 184) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s4.101) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101214@unknown@formal@none@1@S@Interactions between protein kinase domains (Pkinase, Pfam acc. PF00069 and Pkinase_Tyr, Pfam acc. PF07714) are the most frequent iPfam domain pairs, as well as interactions involving recognition domains such as SH2 or SH3.@(((:tag . "NNS") (:stem . "interaction") (:form . "Interactions") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 28)\n  (:start . 21) (:id . 44))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 35)\n  (:start . 29) (:id . 45))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Pkinase") (:form . "Pkinase") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acc.") (:form . "acc.") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PF00069") (:form . "PF00069") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Pkinase_Tyr") (:form . "Pkinase_Tyr") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "acc.") (:form . "acc.") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pf07714") (:form . "PF07714") (:end . 106)\n  (:start . 99) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 120) (:start . 116)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 142)\n  (:start . 136) (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 173)\n  (:start . 161) (:id . 71))\n ((:tag . "VBG") (:stem . "involve") (:form . "involving") (:end . 183)\n  (:start . 174) (:id . 72))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 195)\n  (:start . 184) (:id . 73))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 203)\n  (:start . 196) (:id . 74))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 211) (:start . 209)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "SH2") (:form . "SH2") (:end . 215) (:start . 212)\n  (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 218) (:start . 216)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "SH3") (:form . "SH3") (:end . 222) (:start . 219)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s4.102) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101215@unknown@formal@none@1@S@In S. cerevisiae, the Proteasome family (Pfam acc. PF00227, a family of peptidases) and WD40 (Pfam acc. PF00400, a repeat involved in multimer assembly) are also amongst the five most frequent iPfam domain pairs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "proteasome") (:form . "Proteasome") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pfam") (:form . "Pfam") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "acc.") (:form . "acc.") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PF00227") (:form . "PF00227") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 68)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "peptidase") (:form . "peptidases") (:end . 82)\n  (:start . 72) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "WD40") (:form . "WD40") (:end . 92) (:start . 88)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pfam") (:form . "Pfam") (:end . 98) (:start . 94)\n  (:id . 62))\n ((:tag . "NN") (:stem . "acc.") (:form . "acc.") (:end . 103) (:start . 99)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pf00400") (:form . "PF00400") (:end . 111)\n  (:start . 104) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 66))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 121)\n  (:start . 115) (:id . 67))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 130)\n  (:start . 122) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 69))\n ((:tag . "NN") (:stem . "multimer") (:form . "multimer") (:end . 142)\n  (:start . 134) (:id . 70))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 151)\n  (:start . 143) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 156) (:start . 153)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 161) (:start . 157)\n  (:id . 74))\n ((:tag . "IN") (:stem . "amongst") (:form . "amongst") (:end . 169)\n  (:start . 162) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 76))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 178) (:start . 174)\n  (:id . 77))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 183) (:start . 179)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 192)\n  (:start . 184) (:id . 79))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 198)\n  (:start . 193) (:id . 80))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 205)\n  (:start . 199) (:id . 81))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 211)\n  (:start . 206) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s4.103) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101216@unknown@formal@none@1@S@As expected, more frequent domains are also more likely to be found as pairs in interacting proteins.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 91)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x4.104.1) (:span 49 55)))\n (:hscopes ((:id . :x4.104.1) (:span 13 100)))\n (:identifiers (:sid . :s4.104) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101217@unknown@formal@none@1@S@It should be noted however that in the PDB structures, some of the observed domain pairs (Pkinase_Tyr ↔ SH3_1, Pkinase_C ↔ Pkinase and others) are only seen to interact within one protein (intrachain interactions) as opposed to interactions between two distinct proteins (interchain interaction).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Pkinase_Tyr") (:form . "Pkinase_Tyr") (:end . 101)\n  (:start . 90) (:id . 60))\n ((:tag . "NNP") (:stem . "↔") (:form . "↔") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "SH3_1") (:form . "SH3_1") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Pkinase_C") (:form . "Pkinase_C") (:end . 120)\n  (:start . 111) (:id . 64))\n ((:tag . "NNP") (:stem . "↔") (:form . "↔") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Pkinase") (:form . "Pkinase") (:end . 130)\n  (:start . 123) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 141)\n  (:start . 135) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 146) (:start . 143)\n  (:id . 70))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 151) (:start . 147)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 156) (:start . 152)\n  (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 73))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 168)\n  (:start . 160) (:id . 74))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 175)\n  (:start . 169) (:id . 75))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 179) (:start . 176)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 187)\n  (:start . 180) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 199)\n  (:start . 189) (:id . 79))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 212)\n  (:start . 200) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 81))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 216) (:start . 214)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "oppose") (:form . "opposed") (:end . 224)\n  (:start . 217) (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 227) (:start . 225)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 240)\n  (:start . 228) (:id . 85))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 248)\n  (:start . 241) (:id . 86))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 252) (:start . 249)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 261)\n  (:start . 253) (:id . 88))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 270)\n  (:start . 262) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 272) (:start . 271)\n  (:id . 90))\n ((:tag . "NN") (:stem . "interchain") (:form . "interchain") (:end . 282)\n  (:start . 272) (:id . 91))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 294)\n  (:start . 283) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 295) (:start . 294)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s4.105) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101218@unknown@formal@none@1@S@The table in Additional file 5 lists the number of PDB structures for each iPfam domain pair, distinguishing between intrachain and interchain interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "table") (:form . "table") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "list") (:form . "lists") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "distinguish") (:form . "distinguishing")\n  (:end . 108) (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "interchain") (:form . "interchain") (:end . 142)\n  (:start . 132) (:id . 64))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 155)\n  (:start . 143) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.106) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101220@unknown@formal@none@1@S@A possible explanation for the occurrence of purely intrachain iPfam domain pairs in the covered experimental interactions is that they frequently cooccur together on the same protein with other iPfam domain pairs.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "RB") (:stem . "purely") (:form . "purely") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 68) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 75)\n  (:start . 69) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 109)\n  (:start . 97) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 122)\n  (:start . 110) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 135) (:start . 131)\n  (:id . 61))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 146)\n  (:start . 136) (:id . 62))\n ((:tag . "VBP") (:stem . "cooccur") (:form . "cooccur") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 163)\n  (:start . 155) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 175) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 183)\n  (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 194)\n  (:start . 189) (:id . 70))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 200)\n  (:start . 195) (:id . 71))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 207)\n  (:start . 201) (:id . 72))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 213)\n  (:start . 208) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x4.108.1) (:span 2 10)))\n (:hscopes ((:id . :x4.108.1) (:span 2 213)))\n (:identifiers (:sid . :s4.108) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101221@unknown@formal@none@1@S@A list of all combinations of iPfam domains (the domain architecture) on interacting proteins is given in Additional file 2.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "combination") (:form . "combinations") (:end . 26)\n  (:start . 14) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "architecture") (:form . "architecture") (:end . 68)\n  (:start . 56) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 84)\n  (:start . 73) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 102) (:start . 97)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 116)\n  (:start . 106) (:id . 61))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s4.109) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101222@unknown@formal@none@1@S@It reveals that certain iPfam domains such as SH2, SH3_1 or Pkinase_tyr frequently occur in the same architecture.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "SH2") (:form . "SH2") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "SH3_1") (:form . "SH3_1") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Pkinase_tyr") (:form . "Pkinase_tyr") (:end . 71)\n  (:start . 60) (:id . 54))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 82)\n  (:start . 72) (:id . 55))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "architecture") (:form . "architecture") (:end . 113)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s4.110) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101223@unknown@formal@none@1@S@Without further experiments, we cannot assign the correct interacting domains with certainty.@(((:tag . "IN") (:stem . "without") (:form . "Without") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "further") (:form . "further") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "VB") (:stem . "assign") (:form . "assign") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 69)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "certainty") (:form . "certainty") (:end . 92)\n  (:start . 83) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x4.111.1) (:span 32 45 78 92)))\n (:ncues ((:id . :x4.111.3) (:span 0 7)))\n (:hscopes ((:id . :x4.111.1) (:span 32 92)))\n (:nscopes ((:id . :x4.111.3) (:span 0 27)))\n (:identifiers (:sid . :s4.111) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101224@unknown@formal@none@1@S@This highlights a basic assumption of this study that could be a source of error.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "highlight") (:form . "highlights") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x4.112.1) (:span 54 59)))\n (:hscopes ((:id . :x4.112.1) (:span 54 80)))\n (:identifiers (:sid . :s4.112) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101225@unknown@formal@none@1@S@We assume that interacting proteins that contain an iPfam domain pair interact through these domains.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "assume") (:form . "assume") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x4.113.1) (:span 3 9)))\n (:hscopes ((:id . :x4.113.1) (:span 3 100)))\n (:identifiers (:sid . :s4.113) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101226@unknown@formal@none@1@S@This, of course, is not necessarily the case.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 15) (:start . 9)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 23) (:start . 20)\n  (:id . 48))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 35)\n  (:start . 24) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 45) (:start . 44)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.114) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101227@unknown@formal@none@1@S@Although it has been shown that sequence similarity is linked to the mode of interaction 28, not every protein interaction that contains an iPfam domain pair is necessarily mediated by exactly this domain pair.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 40)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 61) (:start . 55)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mode") (:form . "mode") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 88)\n  (:start . 77) (:id . 56))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 145)\n  (:start . 140) (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 152)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 172)\n  (:start . 161) (:id . 70))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 184) (:start . 182)\n  (:id . 72))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 192)\n  (:start . 185) (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 197) (:start . 193)\n  (:id . 74))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s4.115) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101228@unknown@formal@none@1@S@To gain a rough estimate of the false positive rate due to this assumption, we counted how many protein pairs in the PDB contain an iPfam domain pair that does not mediate an interaction in one complex structure but does so in another.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "gain") (:form . "gain") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "rough") (:form . "rough") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "NN") (:stem . "estimate") (:form . "estimate") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "count") (:form . "counted") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 95) (:start . 91)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 128)\n  (:start . 121) (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 131) (:start . 129)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 144)\n  (:start . 138) (:id . 69))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 149) (:start . 145)\n  (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 159) (:start . 155)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 163) (:start . 160)\n  (:id . 73))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 171)\n  (:start . 164) (:id . 74))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 174) (:start . 172)\n  (:id . 75))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 186)\n  (:start . 175) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 77))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 193) (:start . 190)\n  (:id . 78))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 201)\n  (:start . 194) (:id . 79))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 211)\n  (:start . 202) (:id . 80))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 215) (:start . 212)\n  (:id . 81))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 220) (:start . 216)\n  (:id . 82))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 223) (:start . 221)\n  (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 226) (:start . 224)\n  (:id . 84))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 234)\n  (:start . 227) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x4.116.1) (:span 160 163)))\n (:nscopes ((:id . :x4.116.1) (:span 160 211)))\n (:identifiers (:sid . :s4.116) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101230@unknown@formal@none@1@S@This means that for more than 32% of the protein interactions in the PDB, the iPfam domain pair assignment is correct.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 61)\n  (:start . 49) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 83) (:start . 78)\n  (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 90)\n  (:start . 84) (:id . 60))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "assignment") (:form . "assignment") (:end . 106)\n  (:start . 96) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 117)\n  (:start . 110) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.118) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101231@unknown@formal@none@1@S@For the remaining 68%, the iPfam domain pair assignments are wrong in one case but correct in another.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "CD") (:stem . "68") (:form . "68") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 32) (:start . 27)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 39)\n  (:start . 33) (:id . 50))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "assignment") (:form . "assignments") (:end . 56)\n  (:start . 45) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "wrong") (:form . "wrong") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "correct") (:form . "correct") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 101)\n  (:start . 94) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.119) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101232@unknown@formal@none@1@S@The real false positive rate is likely to be smaller, because some iPfam domain pairs might still independently mediate an interaction with a different, possibly unknown, partner protein.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "real") (:form . "real") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 111) (:start . 98) (:id . 60))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 134)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 151)\n  (:start . 142) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 70))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 178)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 186)\n  (:start . 179) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x4.120.1) (:span 153 161)) ((:id . :x4.120.2) (:span 86 91))\n  ((:id . :x4.120.3) (:span 32 38)))\n (:hscopes ((:id . :x4.120.1) (:span 153 169))\n  ((:id . :x4.120.2) (:span 86 186)) ((:id . :x4.120.3) (:span 0 52)))\n (:identifiers (:sid . :s4.120) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101233@unknown@formal@none@1@S@iPfam domain pairs are enriched in S. cerevisiae complexes@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 58)\n  (:start . 49) (:id . 50)))@@@1@9@((:identifiers (:sid . :s4.121) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101234@unknown@formal@none@1@S@We tested whether iPfam domain pairs are enriched in known protein complexes from S. cerevisiae.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 76)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x4.122.1) (:span 10 17)))\n (:hscopes ((:id . :x4.122.1) (:span 10 95)))\n (:identifiers (:sid . :s4.122) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101235@unknown@formal@none@1@S@This is interesting firstly because domain–domain interactions are thought to be more common in obligate interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "RB") (:stem . "firstly") (:form . "firstly") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 62)\n  (:start . 50) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 74)\n  (:start . 67) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 52))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 92)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "obligate") (:form . "obligate") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 117)\n  (:start . 105) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x4.123.1) (:span 67 74)))\n (:hscopes ((:id . :x4.123.1) (:span 36 117)))\n (:identifiers (:sid . :s4.123) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101236@unknown@formal@none@1@S@Secondly, the described modularity of known S. cerevisiae complexes lends support to the assumption that the underlying iPfam domain pairs are modular.@(((:tag . "RB") (:stem . "secondly") (:form . "Secondly") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "modularity") (:form . "modularity") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 67)\n  (:start . 58) (:id . 51))\n ((:tag . "VBZ") (:stem . "lend") (:form . "lends") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "underlie") (:form . "underlying") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 132)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 142) (:start . 139)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "modular") (:form . "modular") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x4.124.1) (:span 89 99)))\n (:hscopes ((:id . :x4.124.1) (:span 89 150)))\n (:identifiers (:sid . :s4.124) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101237@unknown@formal@none@1@S@In fact, we find a two-fold enrichment for iPfam domain pairs in the complexes described by Gavin et al. 29.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 16) (:start . 12)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "two-fold") (:form . "two-fold") (:end . 27)\n  (:start . 19) (:id . 48))\n ((:tag . "NN") (:stem . "enrichment") (:form . "enrichment") (:end . 38)\n  (:start . 28) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 88)\n  (:start . 79) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Gavin") (:form . "Gavin") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.125) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101238@unknown@formal@none@1@S@From the 294 binary protein interactions in this data set, 24 contained an iPfam domain pair, which corresponds to a coverage of 8.16% (P value 2.7 · 10-47).@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "294") (:form . "294") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 71)\n  (:start . 62) (:id . 54))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 111)\n  (:start . 100) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 125)\n  (:start . 117) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "CD") (:stem . "8.16") (:form . "8.16") (:end . 133) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 134) (:start . 133)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 137) (:start . 136)\n  (:id . 69))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 143)\n  (:start . 138) (:id . 70))\n ((:tag . "CD") (:stem . "2.7") (:form . "2.7") (:end . 147) (:start . 144)\n  (:id . 71))\n ((:tag . "HYPH") (:stem . "·") (:form . "·") (:end . 149) (:start . 148)\n  (:id . 72))\n ((:tag . "CD") (:stem . "10-47") (:form . "10-47") (:end . 155)\n  (:start . 150) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s4.126) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101240@unknown@formal@none@1@S@From 491 complexes described by Gavin et al., 157 contained at least one pair of proteins with an iPfam domain pair (31.9%).@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "491") (:form . "491") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Gavin") (:form . "Gavin") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "CD") (:stem . "157") (:form . "157") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 103) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 110)\n  (:start . 104) (:id . 62))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "CD") (:stem . "31.9") (:form . "31.9") (:end . 121) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s4.128) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101241@unknown@formal@none@1@S@In total we found 617 pairs of proteins that contained an iPfam domain pair.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "total") (:form . "total") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "617") (:form . "617") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "contain") (:form . "contained") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 70)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.129) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101242@unknown@formal@none@1@S@Interestingly, we find that the distribution of iPfam domain pairs on complexes is uneven.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "uneven") (:form . "uneven") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s4.130) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101243@unknown@formal@none@1@S@When we drew 617 protein pairs randomly from all possible protein pairs in the complexes, we covered 192 complexes on average, with a standard deviation of 7.22.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "draw") (:form . "drew") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "617") (:form . "617") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 30) (:start . 25)\n  (:id . 47))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 88)\n  (:start . 79) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "cover") (:form . "covered") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "CD") (:stem . "192") (:form . "192") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 125)\n  (:start . 118) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 142)\n  (:start . 134) (:id . 67))\n ((:tag . "NN") (:stem . "deviation") (:form . "deviation") (:end . 152)\n  (:start . 143) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "CD") (:stem . "7.22") (:form . "7.22") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s4.131) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101244@unknown@formal@none@1@S@The probability of covering only 157 complexes is just 6.24 · 10-07.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "cover") (:form . "covering") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "157") (:form . "157") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "6.24") (:form . "6.24") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "·") (:form . "·") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10-07") (:form . "10-07") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.132) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101245@unknown@formal@none@1@S@Thus, some complexes contain a greater number of iPfam domain pairs, while other complexes do not contain any at all.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 116) (:start . 113)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x4.133.1) (:span 94 97)))\n (:nscopes ((:id . :x4.133.1) (:span 94 116)))\n (:identifiers (:sid . :s4.133) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101246@unknown@formal@none@1@S@This suggests that some sets of domain pairs are specific to certain complexes or pathways.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 78)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x4.134.1) (:span 5 13)))\n (:hscopes ((:id . :x4.134.1) (:span 5 90)))\n (:identifiers (:sid . :s4.134) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101247@unknown@formal@none@1@S@Typical examples are the RNA polymerase II complex (IntAct id: EBI-815049) or the U1 snRNP complex which contain numerous iPfam domain pairs that are specific to these complexes.@(((:tag . "JJ") (:stem . "typical") (:form . "Typical") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "IntAct") (:form . "IntAct") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "id") (:form . "id") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "EBI-815049") (:form . "EBI-815049") (:end . 73)\n  (:start . 63) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "u1") (:form . "U1") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "snrnp") (:form . "snRNP") (:end . 90) (:start . 85)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 61))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 127)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 134)\n  (:start . 128) (:id . 65))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 158)\n  (:start . 150) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 167)\n  (:start . 162) (:id . 71))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 177)\n  (:start . 168) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s4.135) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101248@unknown@formal@none@1@S@iPfam domain pairs are conserved between species@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 48)\n  (:start . 41) (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.136) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101250@unknown@formal@none@1@S@We call an iPfam domain pair conserved when the same pair is observed in experimental interactions of two different species.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "call") (:form . "call") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 85)\n  (:start . 73) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 98)\n  (:start . 86) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.138) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101251@unknown@formal@none@1@S@The matrix in Table 2 shows the pair-wise conservation of iPfam domain pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "pair-wise") (:form . "pair-wise") (:end . 41)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 54)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.139) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101252@unknown@formal@none@1@S@For each species, a maximum of 40% to 90% of iPfam domain pairs can also be found in another species, although not all overlaps are as large.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "maximum") (:form . "maximum") (:end . 27)\n  (:start . 20) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 51))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 40) (:start . 38)\n  (:id . 52))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 41) (:start . 40)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 50) (:start . 45)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 57)\n  (:start . 51) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 63) (:start . 58)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 67) (:start . 64)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 75) (:start . 73)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 81) (:start . 76)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 62))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 92)\n  (:start . 85) (:id . 63))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 100)\n  (:start . 93) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 65))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 110)\n  (:start . 102) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 67))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 118) (:start . 115)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "overlap") (:form . "overlaps") (:end . 127)\n  (:start . 119) (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 131) (:start . 128)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 140)\n  (:start . 135) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s4.140) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101253@unknown@formal@none@1@S@Matrix of mutual shared iPfam domain pairs@(((:tag . "NNP") (:stem . "Matrix") (:form . "Matrix") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutual") (:form . "mutual") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "shared") (:form . "shared") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 42) (:start . 37)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.141) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5101254@unknown@formal@none@1@S@The Table shows the number of co-occurences of iPfam domain pairs between two species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Table") (:form . "Table") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "co-occurence") (:form . "co-occurences")\n  (:end . 43) (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.142) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101255@unknown@formal@none@1@S@The right-most column lists the total number of unique iPfam pairs found in each species' experimental interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "right-most") (:form . "right-most") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "list") (:form . "lists") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "POS") (:stem . "'") (:form . "’") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 102)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 115)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.143) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101256@unknown@formal@none@1@S@Figure 4 shows a Venn diagram of the mutual overlaps between the two eukaryotes S. cerevisiae and H. sapiens and the prokaryote E. coli.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Venn") (:form . "Venn") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "diagram") (:form . "diagram") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mutual") (:form . "mutual") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NNS") (:stem . "overlap") (:form . "overlaps") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 93)\n  (:start . 83) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "prokaryote") (:form . "prokaryote") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.144) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101257@unknown@formal@none@1@S@While the eukaryotes share 524 domain pairs, only 158 iPfam domain pairs are shared between S. cerevisiae and E. coli, and only 135 between E. coli and H. sapiens.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "CD") (:stem . "524") (:form . "524") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "158") (:form . "158") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 105)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "CD") (:stem . "135") (:form . "135") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 154) (:start . 152)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 162)\n  (:start . 155) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s4.145) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101258@unknown@formal@none@1@S@Remarkably, 53% of the observed iPfam domain pairs in E. coli are also observed in one of the two eukaryotes, and 107 iPfam domain pairs are even conserved amongst all three species.@(((:tag . "RB") (:stem . "remarkably") (:form . "Remarkably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "CD") (:stem . "53") (:form . "53") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 56) (:start . 54)\n  (:id . 53))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 61) (:start . 57)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 70) (:start . 66)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 97) (:start . 94)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 108)\n  (:start . 98) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 65))\n ((:tag . "CD") (:stem . "107") (:form . "107") (:end . 117) (:start . 114)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 123)\n  (:start . 118) (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 130)\n  (:start . 124) (:id . 68))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 136)\n  (:start . 131) (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 140) (:start . 137)\n  (:id . 70))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 145) (:start . 141)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 155)\n  (:start . 146) (:id . 72))\n ((:tag . "IN") (:stem . "amongst") (:form . "amongst") (:end . 163)\n  (:start . 156) (:id . 73))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 167) (:start . 164)\n  (:id . 74))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 173)\n  (:start . 168) (:id . 75))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 181)\n  (:start . 174) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s4.146) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101260@unknown@formal@none@1@S@Additional file 3 contains a list of the conserved iPfam domain pairs.@(((:tag . "JJ") (:stem . "additional") (:form . "Additional") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "file") (:form . "file") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.148) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101261@unknown@formal@none@1@S@Venn diagramm showing the fractions of iPfam domain pairs found in the E. coli, S. cerevisiae and H. sapiens binary protein interaction sets@(((:tag . "NNP") (:stem . "Venn") (:form . "Venn") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "diagramm") (:form . "diagramm") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "FW") (:stem . "h.") (:form . "H.") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "FW") (:stem . "sapiens") (:form . "sapiens") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 140) (:start . 136)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.149) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5101262@unknown@formal@none@1@S@Venn diagramm showing the fractions of iPfam domain pairs found in the E. coli, S. cerevisiae and H. sapiens binary protein interaction sets.@(((:tag . "NNP") (:stem . "Venn") (:form . "Venn") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "diagramm") (:form . "diagramm") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "fraction") (:form . "fractions") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 93)\n  (:start . 83) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "FW") (:stem . "h.") (:form . "H.") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "FW") (:stem . "sapiens") (:form . "sapiens") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 123)\n  (:start . 116) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.150) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101263@unknown@formal@none@1@S@The three circles represent the iPfam domain pairs observed in the respective species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "circle") (:form . "circles") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.151) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101264@unknown@formal@none@1@S@The overlaps denote co-observed iPfam domain pairs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "overlap") (:form . "overlaps") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "VBN") (:stem . "co-observe") (:form . "co-observed") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.152) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101265@unknown@formal@none@1@S@The grey set in the background represents iPfam domain pairs not found in the three species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "grey") (:form . "grey") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x4.153.1) (:span 61 64)))\n (:nscopes ((:id . :x4.153.1) (:span 61 91)))\n (:identifiers (:sid . :s4.153) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101266@unknown@formal@none@1@S@We also compared the iPfam domain pair frequencies between H. sapiens and S. cerevisiae directly.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "frequency") (:form . "frequencies") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 87)\n  (:start . 77) (:id . 55))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s4.154) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101267@unknown@formal@none@1@S@We derive a Spearman correlation coefficient of 0.50 for the frequencies of all 524 iPfam domain pairs that are conserved between S. cerevisiae and H. sapiens.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "derive") (:form . "derive") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Spearman") (:form . "Spearman") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "coefficient") (:form . "coefficient") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "CD") (:stem . "0.50") (:form . "0.50") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "frequency") (:form . "frequencies") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "CD") (:stem . "524") (:form . "524") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 143)\n  (:start . 133) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 150) (:start . 148)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 158)\n  (:start . 151) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s4.155) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101268@unknown@formal@none@1@S@To test whether the correlation is an artefact of the distribution of the values, we recalculated the correlation 1000 times, each time shuffling one distribution randomly.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "artefact") (:form . "artefact") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "recalculate") (:form . "recalculated") (:end . 97)\n  (:start . 85) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 113)\n  (:start . 102) (:id . 60))\n ((:tag . "CD") (:stem . "1000") (:form . "1000") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 124)\n  (:start . 119) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "shuffle") (:form . "shuffling") (:end . 145)\n  (:start . 136) (:id . 66))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 162)\n  (:start . 150) (:id . 68))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 171)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x4.156.1) (:span 8 15)))\n (:hscopes ((:id . :x4.156.1) (:span 8 80)))\n (:identifiers (:sid . :s4.156) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101270@unknown@formal@none@1@S@This suggests that iPfam domain pairs with a large number of occurrences in one species tend also to be more frequent in the other.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "occurrence") (:form . "occurrences") (:end . 72)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "VBP") (:stem . "tend") (:form . "tend") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 130)\n  (:start . 125) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x4.158.1) (:span 88 92)) ((:id . :x4.158.2) (:span 5 13)))\n (:hscopes ((:id . :x4.158.1) (:span 88 130))\n  ((:id . :x4.158.2) (:span 5 130)))\n (:identifiers (:sid . :s4.158) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101271@unknown@formal@none@1@S@Predicting the total number of iPfam domain pairs in nature@(((:tag . "VBG") (:stem . "predict") (:form . "Predicting") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 59)\n  (:start . 53) (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.159) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101272@unknown@formal@none@1@S@Our analysis allow us to estimate how many iPfam domain pairs would eventually cover all protein interactions.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "allow") (:form . "allow") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "eventually") (:form . "eventually") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 109)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x4.160.1) (:span 62 67)))\n (:hscopes ((:id . :x4.160.1) (:span 62 109)))\n (:identifiers (:sid . :s4.160) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101273@unknown@formal@none@1@S@This corresponds to the predictions made by Aloy and Russel 2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Aloy") (:form . "Aloy") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Russel") (:form . "Russel") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s4.161) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101274@unknown@formal@none@1@S@Similar to their approach, we make a linear estimation with the following factors:@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 16)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "estimation") (:form . "estimation") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 82) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.162) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101275@unknown@formal@none@1@S@χS The number of iPfam domain pairs observed in species S@(((:tag . "VBZ") (:stem . "χs") (:form . "χS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.163) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101276@unknown@formal@none@1@S@θS The number of observed interactions in species S that contain an iPfam domain pair@(((:tag . "VBZ") (:stem . "θs") (:form . "θS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 85) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.164) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101277@unknown@formal@none@1@S@ΘS The total number of observed interactions in species S@(((:tag . "VBZ") (:stem . "θs") (:form . "ΘS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 57) (:start . 56)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.165) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101278@unknown@formal@none@1@S@ψS The number of proteins from species S that are seen in an interaction screen@(((:tag . "VBZ") (:stem . "ψs") (:form . "ψS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 72)\n  (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 79)\n  (:start . 73) (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.166) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101280@unknown@formal@none@1@S@ξS The number of Pfam domains observed in all protein of species S@(((:tag . "VBZ") (:stem . "ξs") (:form . "ξS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 66) (:start . 65)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.168) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101281@unknown@formal@none@1@S@Ξ The total number of known Pfam domains@(((:tag . "LS") (:stem . "ξ") (:form . "Ξ") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 40)\n  (:start . 33) (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.169) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101282@unknown@formal@none@1@S@We denote the estimated number of iPfam domain pairs in species S with x^S.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "x^s") (:form . "x^S") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.170) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101283@unknown@formal@none@1@S@The formula we apply is x^S=χS⋅ΘSθS⋅ΨSψS@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "formula") (:form . "formula") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "apply") (:form . "apply") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "x^s=χs⋅θsθs⋅ψsψs") (:form . "x^S=χS⋅ΘSθS⋅ΨSψS")\n  (:end . 40) (:start . 24) (:id . 47)))@@@1@6@((:identifiers (:sid . :s4.171) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101284@unknown@formal@none@1@S@This means we scale the observed number of iPfam domain pairs to cover all observed interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "scale") (:form . "scale") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 96)\n  (:start . 84) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.172) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101285@unknown@formal@none@1@S@We then use the relative proteome coverage to estimate the total number of iPfam domain pairs in all proteins.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "use") (:form . "use") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s4.173) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101286@unknown@formal@none@1@S@Finally, we follow the argument of Aloy and Russel that the number of Pfam families seen in species S indicates the fraction of the protein universe represented in the species.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "follow") (:form . "follow") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "argument") (:form . "argument") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Aloy") (:form . "Aloy") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Russel") (:form . "Russel") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 66)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 74) (:start . 70)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 99)\n  (:start . 92) (:id . 60))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 111)\n  (:start . 102) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 124)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 139)\n  (:start . 132) (:id . 67))\n ((:tag . "NN") (:stem . "universe") (:form . "universe") (:end . 148)\n  (:start . 140) (:id . 68))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 160)\n  (:start . 149) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s4.174) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101287@unknown@formal@none@1@S@We therefore predict the total number of iPfam domain pairs x^ as x^=x^S⋅ΞξS.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "predict") (:form . "predict") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "x^") (:form . "x^") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "x^=x^s⋅ξξs") (:form . "x^=x^S⋅ΞξS") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.175) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101288@unknown@formal@none@1@S@Both parameters and results of the calculation are shown in Table 3.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "calculation") (:form . "calculation") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.176) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101290@unknown@formal@none@1@S@Prediction of total number of iPfam domain pairs@(((:tag . "NN") (:stem . "prediction") (:form . "Prediction") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.178) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|TableLegend|)))@oe@9-2-2011
5101291@unknown@formal@none@1@S@ΘS The total number of observed interactions in species S@(((:tag . "VBZ") (:stem . "θs") (:form . "ΘS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 31)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 44)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 57) (:start . 56)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.179) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101292@unknown@formal@none@1@S@θS The number of observed interactions in species S that contain an iPfam domain pair@(((:tag . "VBZ") (:stem . "θs") (:form . "θS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 85) (:start . 81)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.180) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101293@unknown@formal@none@1@S@ΨS The proteome size for species S@(((:tag . "VBZ") (:stem . "ψs") (:form . "ΨS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "proteome") (:form . "proteome") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 34) (:start . 33)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.181) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101294@unknown@formal@none@1@S@ψS The number of proteins from species S that are seen in an interaction screen@(((:tag . "VBZ") (:stem . "ψs") (:form . "ψS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 72)\n  (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "screen") (:form . "screen") (:end . 79)\n  (:start . 73) (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.182) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101295@unknown@formal@none@1@S@χS The number of iPfam domain pairs observed in species S@(((:tag . "VBZ") (:stem . "χs") (:form . "χS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 57) (:start . 56)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.183) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101296@unknown@formal@none@1@S@The predicted total number of iPfam domain pairs in species S@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 61) (:start . 60)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.184) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101297@unknown@formal@none@1@S@Ξ The total number of known Pfam domains@(((:tag . "LS") (:stem . "ξ") (:form . "Ξ") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 40)\n  (:start . 33) (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.185) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101298@unknown@formal@none@1@S@ζS The number of Pfam domains observed in all protein of species S@(((:tag . "VBZ") (:stem . "ζs") (:form . "ζS") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NNP") (:stem . "S") (:form . "S") (:end . 66) (:start . 65)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.186) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101300@unknown@formal@none@1@S@Prediction results are shown in bold font.@(((:tag . "NN") (:stem . "prediction") (:form . "Prediction") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "bold") (:form . "bold") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.188) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101301@unknown@formal@none@1@S@Discussion@(((:tag . "NN") (:stem . "discussion") (:form . "Discussion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.189) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5101302@unknown@formal@none@1@S@iPfam coverage is low@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 21) (:start . 18)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s4.190) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101303@unknown@formal@none@1@S@The coverage of iPfam on experimentally derived protein interactions is low.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s4.191) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101304@unknown@formal@none@1@S@For S. cerevisiae, the species with the best mapped interactome, only 4.47% of the protein interactions contain an iPfam domain pair.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 17)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 51) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 63)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "CD") (:stem . "4.47") (:form . "4.47") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 59))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 103)\n  (:start . 91) (:id . 60))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.192) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101305@unknown@formal@none@1@S@Even in H. sapiens, where we suspect a positive bias due to the overrepresentation of disease-related proteins in both the PDB and protein interaction databases, 81% of protein interactions do not contain an iPfam domain pair.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "suspect") (:form . "suspect") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 82) (:start . 64) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "disease-related") (:form . "disease-related")\n  (:end . 101) (:start . 86) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 110)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pdb") (:form . "PDB") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 150)\n  (:start . 139) (:id . 66))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "CD") (:stem . "81") (:form . "81") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 176)\n  (:start . 169) (:id . 72))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 189)\n  (:start . 177) (:id . 73))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 192) (:start . 190)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 204)\n  (:start . 197) (:id . 76))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 207) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 213)\n  (:start . 208) (:id . 78))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 220)\n  (:start . 214) (:id . 79))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x4.193.2) (:span 29 36)))\n (:ncues ((:id . :x4.193.1) (:span 193 196)))\n (:hscopes ((:id . :x4.193.2) (:span 29 160)))\n (:nscopes ((:id . :x4.193.1) (:span 193 225)))\n (:identifiers (:sid . :s4.193) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101306@unknown@formal@none@1@S@This reveals the limits of our understanding of the molecular structure of protein interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "reveal") (:form . "reveals") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "limit") (:form . "limits") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 44) (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 95)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.194) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101307@unknown@formal@none@1@S@Figure 1 also shows that a majority of protein interactions contains at least one pair of Pfam domains.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 59)\n  (:start . 47) (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 102)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.195) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101308@unknown@formal@none@1@S@ While there is no structural information about putative interactions between these pairs, this fraction can already be analysed using statistical methods to identify putative domain interactions 7910.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 6) (:start . 1)\n  (:id . 42))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 77)\n  (:start . 70) (:id . 51))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 83) (:start . 78)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 89) (:start . 84)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 104)\n  (:start . 96) (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 116)\n  (:start . 109) (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "analyse") (:form . "analysed") (:end . 128)\n  (:start . 120) (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 134) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 146)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 154)\n  (:start . 147) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 64))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 175)\n  (:start . 167) (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 182)\n  (:start . 176) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 195)\n  (:start . 183) (:id . 68))\n ((:tag . "CD") (:stem . "7910") (:form . "7910") (:end . 200) (:start . 196)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x4.196.1) (:span 16 18)))\n (:nscopes ((:id . :x4.196.1) (:span 16 89)))\n (:identifiers (:sid . :s4.196) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101310@unknown@formal@none@1@S@Prioritising these targets according to the number of covered experimental interactions could increase the coverage of databases like iPfam quickly.@(((:tag . "VBG") (:stem . "prioritise") (:form . "Prioritising") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "cover") (:form . "covered") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 74)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 87)\n  (:start . 75) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 93) (:start . 88)\n  (:id . 53))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 102)\n  (:start . 94) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 55))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 115)\n  (:start . 107) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 128)\n  (:start . 119) (:id . 58))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 139)\n  (:start . 134) (:id . 60))\n ((:tag . "RB") (:stem . "quickly") (:form . "quickly") (:end . 147)\n  (:start . 140) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x4.198.1) (:span 88 93)))\n (:hscopes ((:id . :x4.198.1) (:span 88 147)))\n (:identifiers (:sid . :s4.198) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101311@unknown@formal@none@1@S@We find, however, that iPfam domain pairs occur significantly more often in experimental interactions than would be expected by chance.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 47) (:start . 42)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 61) (:start . 48) (:id . 52))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 88)\n  (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 101)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 112)\n  (:start . 107) (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x4.199.1) (:span 107 112)))\n (:hscopes ((:id . :x4.199.1) (:span 107 134)))\n (:identifiers (:sid . :s4.199) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101312@unknown@formal@none@1@S@This requires that at least a subset of the iPfam domain pairs are reused in several experimental interactions.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reuse") (:form . "reused") (:end . 73)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 97)\n  (:start . 85) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 110)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.200) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101313@unknown@formal@none@1@S@iPfam domain pairs can act as modules@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 37)\n  (:start . 30) (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.201) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101314@unknown@formal@none@1@S@Despite the low overall coverage, iPfam domain pairs are found in more protein interactions than would be expected by chance (see Table 1).@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 91)\n  (:start . 79) (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 114)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 137) (:start . 136)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x4.202.1) (:span 97 102)))\n (:hscopes ((:id . :x4.202.1) (:span 97 124)))\n (:identifiers (:sid . :s4.202) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101315@unknown@formal@none@1@S@This statistical overrepresentation suggests that certain iPfam domain pairs constitute modules of molecular recognition which are reused in different protein interactions 2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "overrepresentation") (:form . "overrepresentation")\n  (:end . 35) (:start . 17) (:id . 44))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 44)\n  (:start . 36) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 57)\n  (:start . 50) (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 63) (:start . 58)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 70)\n  (:start . 64) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 76) (:start . 71)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "constitute") (:form . "constitute") (:end . 87)\n  (:start . 77) (:id . 51))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 95)\n  (:start . 88) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 108)\n  (:start . 99) (:id . 54))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 120)\n  (:start . 109) (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "reuse") (:form . "reused") (:end . 137)\n  (:start . 131) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 150)\n  (:start . 141) (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 158)\n  (:start . 151) (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 171)\n  (:start . 159) (:id . 62))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 173) (:start . 172)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x4.203.1) (:span 36 44)))\n (:hscopes ((:id . :x4.203.1) (:span 36 171)))\n (:identifiers (:sid . :s4.203) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101316@unknown@formal@none@1@S@In fact, we find a characteristic power law distribution when we plot the histogram of experimental interactions per iPfam domain pair, see Figure 2.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 16) (:start . 12)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 33) (:start . 19) (:id . 48))\n ((:tag . "NN") (:stem . "power") (:form . "power") (:end . 39) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "law") (:form . "law") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 56)\n  (:start . 44) (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "plot") (:form . "plot") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "histogram") (:form . "histogram") (:end . 83)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 99)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 112)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 129)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 134) (:start . 130)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "see") (:form . "see") (:end . 139) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s4.204) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101317@unknown@formal@none@1@S@This underlines that a few promiscuous iPfam domain pairs are responsible for the majority of the iPfam coverage.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "underline") (:form . "underlines") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "promiscuous") (:form . "promiscuous") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 73)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "majority") (:form . "majority") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.205) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101318@unknown@formal@none@1@S@These iPfam domain pairs are most likely to be reusable modules.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "reusable") (:form . "reusable") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x4.206.1) (:span 34 40)))\n (:hscopes ((:id . :x4.206.1) (:span 0 63)))\n (:identifiers (:sid . :s4.206) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101320@unknown@formal@none@1@S@Conversely, a large number of iPfam domain pairs are specific to a small number of protein interactions.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 103)\n  (:start . 91) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.208) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101321@unknown@formal@none@1@S@This implies that recognition specificity amongst proteins is often achieved by maintaining an exclusive interacting domain pair.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "imply") (:form . "implies") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "amongst") (:form . "amongst") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 58)\n  (:start . 50) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 49))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "maintain") (:form . "maintaining") (:end . 91)\n  (:start . 80) (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "exclusive") (:form . "exclusive") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 116)\n  (:start . 105) (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 123)\n  (:start . 117) (:id . 57))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 128) (:start . 124)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x4.209.1) (:span 5 12)))\n (:hscopes ((:id . :x4.209.1) (:span 5 128)))\n (:identifiers (:sid . :s4.209) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101322@unknown@formal@none@1@S@This could pose a problem for purely statistical approaches to infer domain interactions:: if for many interfaces the real interacting domain pair will only occur once in an interactome, it will be hard to elucidate this on a statistical basis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "pose") (:form . "pose") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "problem") (:form . "problem") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "purely") (:form . "purely") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 48)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "VB") (:stem . "infer") (:form . "infer") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 88)\n  (:start . 76) (:id . 54))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 89) (:start . 88)\n  (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 90) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "interface") (:form . "interfaces") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "real") (:form . "real") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 134)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 162)\n  (:start . 157) (:id . 68))\n ((:tag . "RB") (:stem . "once") (:form . "once") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "interactome") (:form . "interactome") (:end . 185)\n  (:start . 174) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 189) (:start . 187)\n  (:id . 74))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 197) (:start . 195)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "hard") (:form . "hard") (:end . 202) (:start . 198)\n  (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 205) (:start . 203)\n  (:id . 78))\n ((:tag . "VB") (:stem . "elucidate") (:form . "elucidate") (:end . 215)\n  (:start . 206) (:id . 79))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 220) (:start . 216)\n  (:id . 80))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 223) (:start . 221)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 225) (:start . 224)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 237)\n  (:start . 226) (:id . 83))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 243)\n  (:start . 238) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x4.210.1) (:span 5 10)))\n (:hscopes ((:id . :x4.210.1) (:span 5 88)))\n (:identifiers (:sid . :s4.210) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101323@unknown@formal@none@1@S@The concept of modularity of interacting domain pairs is furthermore supported by the positive correlation between the number of protein interactions an iPfam domain pair is seen in and the connectivity of the interacting proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "concept") (:form . "concept") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "modularity") (:form . "modularity") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 40)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "RB") (:stem . "furthermore") (:form . "furthermore") (:end . 68)\n  (:start . 57) (:id . 51))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 78)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 106)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 114)\n  (:start . 107) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 58))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 125)\n  (:start . 119) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 149)\n  (:start . 137) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 158)\n  (:start . 153) (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 165)\n  (:start . 159) (:id . 65))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 170) (:start . 166)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 178) (:start . 174)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 71))\n ((:tag . "NN") (:stem . "connectivity") (:form . "connectivity") (:end . 202)\n  (:start . 190) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 221)\n  (:start . 210) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 230)\n  (:start . 222) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s4.211) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101324@unknown@formal@none@1@S@We hypothesise that if during the course of evolution a protein is duplicated, it is likely to retain connections with other proteins which contain the same domain interaction modules.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "hypothesise") (:form . "hypothesise") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "duplicate") (:form . "duplicated") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "VB") (:stem . "retain") (:form . "retain") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "NNS") (:stem . "connection") (:form . "connections") (:end . 113)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 124)\n  (:start . 119) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 147)\n  (:start . 140) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 163)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 175)\n  (:start . 164) (:id . 70))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x4.212.1) (:span 85 91)) ((:id . :x4.212.2) (:span 3 14)))\n (:hscopes ((:id . :x4.212.1) (:span 79 183))\n  ((:id . :x4.212.2) (:span 3 183)))\n (:identifiers (:sid . :s4.212) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101325@unknown@formal@none@1@S@It is clear, however, that even though recognition domains are reused in various proteins, their specificity is bound to be controlled.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 11) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 20)\n  (:start . 13) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 48))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "IN") (:stem . "though") (:form . "though") (:end . 38)\n  (:start . 32) (:id . 50))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 50)\n  (:start . 39) (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "reuse") (:form . "reused") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 96)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 117)\n  (:start . 112) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 123) (:start . 121)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "control") (:form . "controlled") (:end . 134)\n  (:start . 124) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.213) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101326@unknown@formal@none@1@S@Many domain–domain interfaces remain to be resolved@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain–domain") (:form . "domain–domain")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "interface") (:form . "interfaces") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 36)\n  (:start . 30) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "resolve") (:form . "resolved") (:end . 51)\n  (:start . 43) (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.214) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101327@unknown@formal@none@1@S@We tried to estimate how many iPfam domain pairs exists in all interactomes.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "try") (:form . "tried") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "estimate") (:form . "estimate") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "interactome") (:form . "interactomes") (:end . 75)\n  (:start . 63) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.215) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101328@unknown@formal@none@1@S@Our predictions lie almost an order of magnitude higher than the 10000 domain interaction types proposed by Aloy and Russel 2.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "prediction") (:form . "predictions") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "lie") (:form . "lie") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "magnitude") (:form . "magnitude") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10000") (:form . "10000") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 89)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Aloy") (:form . "Aloy") (:end . 112) (:start . 108)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Russel") (:form . "Russel") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.216) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101330@unknown@formal@none@1@S@The statistical approaches described in the introduction can only cover a small fraction of this domaininteraction space.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "introduction") (:form . "introduction") (:end . 56)\n  (:start . 44) (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "VB") (:stem . "cover") (:form . "cover") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domaininteraction") (:form . "domaininteraction")\n  (:end . 114) (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "space") (:form . "space") (:end . 120)\n  (:start . 115) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.218) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101331@unknown@formal@none@1@S@Riley et al. for example report only 3005 interacting domain pairs which could be inferred from protein interactions 7.@(((:tag . "NNP") (:stem . "Riley") (:form . "Riley") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3005") (:form . "3005") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "infer") (:form . "inferred") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 116)\n  (:start . 104) (:id . 59))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s4.219) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101332@unknown@formal@none@1@S@Even under the assumption that many interactions involve short linear motifs, it seems likely that a large number of domain interactions remain to be resolved.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "assumption") (:form . "assumption") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "VBP") (:stem . "involve") (:form . "involve") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "linear") (:form . "linear") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 106)\n  (:start . 101) (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "resolve") (:form . "resolved") (:end . 158)\n  (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x4.220.1) (:span 87 93)) ((:id . :x4.220.2) (:span 81 86))\n  ((:id . :x4.220.3) (:span 15 25)))\n (:hscopes ((:id . :x4.220.1) (:span 87 158))\n  ((:id . :x4.220.2) (:span 81 158)) ((:id . :x4.220.3) (:span 15 158)))\n (:identifiers (:sid . :s4.220) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101333@unknown@formal@none@1@S@iPfam domain pairs are conserved during evolution@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 49)\n  (:start . 40) (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.221) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101334@unknown@formal@none@1@S@iPfam domain pairs are not only recurrent within the protein interaction network of one species.@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "recurrent") (:form . "recurrent") (:end . 41)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s4.222) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101335@unknown@formal@none@1@S@They also appear to be conserved between species.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:hcues ((:id . :x4.223.1) (:span 10 16)))\n (:hscopes ((:id . :x4.223.1) (:span 0 48)))\n (:identifiers (:sid . :s4.223) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101336@unknown@formal@none@1@S@In a small set of protein structures from S. cerevisiae, it has been shown that interacting domain pairs are more conserved than non-interacting domain pairs 10.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 10) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 47))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 55)\n  (:start . 45) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 91)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 113) (:start . 109)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 123)\n  (:start . 114) (:id . 63))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 128) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "non-interacting") (:form . "non-interacting")\n  (:end . 144) (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 160) (:start . 158)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.224) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101337@unknown@formal@none@1@S@Here, we call an iPfam domain pair conserved if there are protein interactions in two species which contain the same iPfam domain pair.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "call") (:form . "call") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 22) (:start . 17)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 44)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 78)\n  (:start . 66) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 107)\n  (:start . 100) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 122)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 129)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.225) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101338@unknown@formal@none@1@S@In a recent study 31, Gandhi et al. have assessed the conservation of protein interactions as the co-occurrence of orthologous interacting proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "CD") (:stem . "31") (:form . "31") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Gandhi") (:form . "Gandhi") (:end . 28)\n  (:start . 22) (:id . 48))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 40) (:start . 36)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "assess") (:form . "assessed") (:end . 49)\n  (:start . 41) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 66)\n  (:start . 54) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 90)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "co-occurrence") (:form . "co-occurrence")\n  (:end . 111) (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "orthologous") (:form . "orthologous") (:end . 126)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "interacting") (:form . "interacting") (:end . 138)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.226) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101340@unknown@formal@none@1@S@Conversely, we find that 71 iPfam domain pairs are conserved in the experimental interactions of these species.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "find") (:form . "find") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "CD") (:stem . "71") (:form . "71") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 60)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 80)\n  (:start . 68) (:id . 55))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 93)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 102) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 110)\n  (:start . 103) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.228) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101341@unknown@formal@none@1@S@Even between a prokaryote like E. coli and the two eukaryotes S. cerevisiae and H. sapiens there is a considerable proportion of conserved iPfam domain pairs, to the extent that 53% of the iPfam domain pairs from E. coli are also observed in a eukaryote (Table 2).@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "prokaryote") (:form . "prokaryote") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 75)\n  (:start . 65) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 90)\n  (:start . 83) (:id . 57))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 114)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "NN") (:stem . "extent") (:form . "extent") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 177) (:start . 173)\n  (:id . 72))\n ((:tag . "CD") (:stem . "53") (:form . "53") (:end . 180) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 194)\n  (:start . 189) (:id . 77))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 201)\n  (:start . 195) (:id . 78))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 207)\n  (:start . 202) (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 212) (:start . 208)\n  (:id . 80))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 215) (:start . 213)\n  (:id . 81))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 220) (:start . 216)\n  (:id . 82))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 224) (:start . 221)\n  (:id . 83))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 229) (:start . 225)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 238)\n  (:start . 230) (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 241) (:start . 239)\n  (:id . 86))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 243) (:start . 242)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "eukaryote") (:form . "eukaryote") (:end . 253)\n  (:start . 244) (:id . 88))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 255) (:start . 254)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 260)\n  (:start . 255) (:id . 90))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 262) (:start . 261)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 263) (:start . 262)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s4.229) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101342@unknown@formal@none@1@S@107 domain pairs are shared between E. coli, S. cerevisiae and H. sapiens.@(((:tag . "CD") (:stem . "107") (:form . "107") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "coli") (:form . "coli") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.230) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101343@unknown@formal@none@1@S@These domains are predominantly related to transcription, translation and other basic essential cellular activities, which is in congruence with the findings of Gandhi et al.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 56) (:start . 43) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NN") (:stem . "translation") (:form . "translation") (:end . 69)\n  (:start . 58) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 95)\n  (:start . 86) (:id . 54))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 122)\n  (:start . 117) (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 125) (:start . 123)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "congruence") (:form . "congruence") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 144) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 157)\n  (:start . 149) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Gandhi") (:form . "Gandhi") (:end . 167)\n  (:start . 161) (:id . 66))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "FW") (:stem . "al") (:form . "al") (:end . 173) (:start . 171)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.231) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101344@unknown@formal@none@1@S@Although the low overall iPfam coverage hampers the interpretation of our results, it looks as if there has been a diversification of domain interactions from E. coli to H. sapiens.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "VBZ") (:stem . "hamper") (:form . "hampers") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 66) (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "look") (:form . "looks") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "NN") (:stem . "diversification") (:form . "diversification")\n  (:end . 130) (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 140)\n  (:start . 134) (:id . 65))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 153)\n  (:start . 141) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 161) (:start . 159)\n  (:id . 68))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 180)\n  (:start . 173) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x4.232.1) (:span 86 94)))\n (:hscopes ((:id . :x4.232.1) (:span 86 180)))\n (:identifiers (:sid . :s4.232) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101345@unknown@formal@none@1@S@While more than half of the iPfam domain pairs in E. coli have been retained throughout evolution, numerous new ones seem to have emerged in eukaryotic development.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 62) (:start . 58)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "retain") (:form . "retained") (:end . 76)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 87)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 107)\n  (:start . 99) (:id . 60))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "seem") (:form . "seem") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 163)\n  (:start . 152) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x4.233.1) (:span 117 121)))\n (:hscopes ((:id . :x4.233.1) (:span 99 163)))\n (:identifiers (:sid . :s4.233) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101346@unknown@formal@none@1@S@The significant positive correlation in the frequency of iPfam domain pairs conserved between S. cerevisiae and H. sapiens also suggests that the binding interfaces are more often kept or even reused rather than lost in the course of evolution.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "NN") (:stem . "correlation") (:form . "correlation") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 127) (:start . 123)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 136)\n  (:start . 128) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 63))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 153)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "interface") (:form . "interfaces") (:end . 164)\n  (:start . 154) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 173) (:start . 169)\n  (:id . 67))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 179)\n  (:start . 174) (:id . 68))\n ((:tag . "VBD") (:stem . "keep") (:form . "kept") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 192) (:start . 188)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "reuse") (:form . "reused") (:end . 199)\n  (:start . 193) (:id . 72))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 206)\n  (:start . 200) (:id . 73))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 211) (:start . 207)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 216) (:start . 212)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 77))\n ((:tag . "NN") (:stem . "course") (:form . "course") (:end . 230)\n  (:start . 224) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 233) (:start . 231)\n  (:id . 79))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 243)\n  (:start . 234) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x4.234.2) (:span 185 187))\n  ((:id . :x4.234.3) (:span 128 136)))\n (:ncues ((:id . :x4.234.1) (:span 200 211)))\n (:hscopes ((:id . :x4.234.2) (:span 180 199))\n  ((:id . :x4.234.3) (:span 128 243)))\n (:nscopes ((:id . :x4.234.1) (:span 200 216)))\n (:identifiers (:sid . :s4.234) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101347@unknown@formal@none@1@S@Conversely, this also raises the question of whether one could establish a comprehensive set of domain interactions that were present in the last universal common ancestor.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "PRP") (:stem . "one") (:form . "one") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "VB") (:stem . "establish") (:form . "establish") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "comprehensive") (:form . "comprehensive")\n  (:end . 88) (:start . 75) (:id . 55))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 115)\n  (:start . 103) (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 125) (:start . 121)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 133)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 145) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "universal") (:form . "universal") (:end . 155)\n  (:start . 146) (:id . 66))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 162)\n  (:start . 156) (:id . 67))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x4.235.1) (:span 57 62)) ((:id . :x4.235.2) (:span 45 52))\n  ((:id . :x4.235.3) (:span 22 41)))\n (:hscopes ((:id . :x4.235.1) (:span 57 171))\n  ((:id . :x4.235.2) (:span 45 171)) ((:id . :x4.235.3) (:span 22 171)))\n (:identifiers (:sid . :s4.235) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101348@unknown@formal@none@1@S@Conclusion@(((:tag . "NN") (:stem . "conclusion") (:form . "Conclusion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.236) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5101350@unknown@formal@none@1@S@Disappointingly, only a small fraction of all experimental interactions can be attributed to a known domain interaction.@(((:tag . "RB") (:stem . "disappointingly") (:form . "Disappointingly")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fraction") (:form . "fraction") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 58)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 100) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 119)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.238) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101351@unknown@formal@none@1@S@Within this subset of interactions, we nevertheless made several reassuring observations: structural domain pairs are enriched in experimental protein interactions.@(((:tag . "IN") (:stem . "within") (:form . "Within") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "nevertheless") (:form . "nevertheless") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "VBD") (:stem . "make") (:form . "made") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "VBG") (:stem . "reassure") (:form . "reassuring") (:end . 75)\n  (:start . 65) (:id . 52))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 88)\n  (:start . 76) (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 107)\n  (:start . 101) (:id . 56))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 113)\n  (:start . 108) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "enrich") (:form . "enriched") (:end . 126)\n  (:start . 118) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 142)\n  (:start . 130) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 150)\n  (:start . 143) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 163)\n  (:start . 151) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s4.239) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101352@unknown@formal@none@1@S@Some of the domain pairs seem to mediate a large number of protein interactions, thus acting as reusable connectors.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "seem") (:form . "seem") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VB") (:stem . "mediate") (:form . "mediate") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 79)\n  (:start . 67) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "act") (:form . "acting") (:end . 92) (:start . 86)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "reusable") (:form . "reusable") (:end . 104)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "connector") (:form . "connectors") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x4.240.1) (:span 25 29)))\n (:hscopes ((:id . :x4.240.1) (:span 25 115)))\n (:identifiers (:sid . :s4.240) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101353@unknown@formal@none@1@S@This property is also conserved between species.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s4.241) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101354@unknown@formal@none@1@S@Taken as a whole, this further underlines that solving structures of protein complexes should be an important focus for future structural genomics projects.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "whole") (:form . "whole") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 30)\n  (:start . 23) (:id . 48))\n ((:tag . "VBZ") (:stem . "underline") (:form . "underlines") (:end . 41)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "solve") (:form . "solving") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 109)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "focus") (:form . "focus") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "future") (:form . "future") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 137)\n  (:start . 127) (:id . 63))\n ((:tag . "NNS") (:stem . "genomic") (:form . "genomics") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "NNS") (:stem . "project") (:form . "projects") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.242) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101355@unknown@formal@none@1@S@Targeting the most frequent domain pairs would increase the coverage of databases such as iPfam, shedding more light onto the molecular mechanisms underpinning cellular networks.@(((:tag . "VBG") (:stem . "target") (:form . "Targeting") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "frequent") (:form . "frequent") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "VB") (:stem . "increase") (:form . "increase") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "coverage") (:form . "coverage") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 95) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "shed") (:form . "shedding") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "IN") (:stem . "onto") (:form . "onto") (:end . 121) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "VBG") (:stem . "underpin") (:form . "underpinning") (:end . 159)\n  (:start . 147) (:id . 65))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 168)\n  (:start . 160) (:id . 66))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 177)\n  (:start . 169) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x4.243.1) (:span 41 46)))\n (:hscopes ((:id . :x4.243.1) (:span 41 177)))\n (:identifiers (:sid . :s4.243) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101356@unknown@formal@none@1@S@Methods@(((:tag . "NNS") (:stem . "method") (:form . "Methods") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.244) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Title|)))@oe@9-2-2011
5101357@unknown@formal@none@1@S@Protein interaction data@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 24) (:start . 20)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s4.245) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101358@unknown@formal@none@1@S@The complete interaction sets from BioGRID 20, DIP 21, HPRD 22, IntAct 23 and MPact 24 were downloaded.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BioGRID") (:form . "BioGRID") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DIP") (:form . "DIP") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 59) (:start . 55)\n  (:id . 53))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "IntAct") (:form . "IntAct") (:end . 70)\n  (:start . 64) (:id . 56))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MPact") (:form . "MPact") (:end . 83) (:start . 78)\n  (:id . 59))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 91) (:start . 87)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 102)\n  (:start . 92) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.246) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101360@unknown@formal@none@1@S@BioGRID for example contains a large manually curated set of protein interactions for S. cerevisiae 19.@(((:tag . "NN") (:stem . "biogrid") (:form . "BioGRID") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "RB") (:stem . "manually") (:form . "manually") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "VBN") (:stem . "curate") (:form . "curated") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.248) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101361@unknown@formal@none@1@S@Similarily, HPRD hosts a set of manually curated protein interactions for H. sapiens.@(((:tag . "RB") (:stem . "similarily") (:form . "Similarily") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "HPRD") (:form . "HPRD") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "host") (:form . "hosts") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "RB") (:stem . "manually") (:form . "manually") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "VBN") (:stem . "curate") (:form . "curated") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 69)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.249) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101362@unknown@formal@none@1@S@IntAct on the other hand contains results from high-throughput screens and integrates data from other protein interaction databases as part of the IMEx collaboration.@(((:tag . "NN") (:stem . "intact") (:form . "IntAct") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "NNS") (:stem . "screen") (:form . "screens") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "integrate") (:form . "integrates") (:end . 85)\n  (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 101) (:start . 96)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 121)\n  (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 60))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "IMEx") (:form . "IMEx") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "NN") (:stem . "collaboration") (:form . "collaboration")\n  (:end . 165) (:start . 152) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.250) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101363@unknown@formal@none@1@S@The MPact database combines the manually curated S. cerevisiae protein complexes data set formerly known as the MIPS complexes with other high-throughput interaction experiments data.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MPact") (:form . "MPact") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "combine") (:form . "combines") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "RB") (:stem . "manually") (:form . "manually") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBN") (:stem . "curate") (:form . "curated") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 80)\n  (:start . 71) (:id . 52))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "set") (:form . "set") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "RB") (:stem . "formerly") (:form . "formerly") (:end . 98)\n  (:start . 90) (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 104) (:start . 99)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MIPS") (:form . "MIPS") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "complex") (:form . "complexes") (:end . 126)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 137)\n  (:start . 132) (:id . 62))\n ((:tag . "JJ") (:stem . "high-throughput") (:form . "high-throughput")\n  (:end . 153) (:start . 138) (:id . 63))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 165)\n  (:start . 154) (:id . 64))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 177)\n  (:start . 166) (:id . 65))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 182)\n  (:start . 178) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s4.251) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101364@unknown@formal@none@1@S@Taken together, these databases represent most of the protein interactions currently stored in machine-accessible form.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 74)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "VBN") (:stem . "store") (:form . "stored") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "machine-accessible") (:form . "machine-accessible")\n  (:end . 113) (:start . 95) (:id . 56))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 118) (:start . 114)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.252) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101365@unknown@formal@none@1@S@Despite great efforts to unify access to protein interaction data 32, acquiring large data sets from diverse sources is still far from trivial and error prone.@(((:tag . "IN") (:stem . "despite") (:form . "Despite") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "effort") (:form . "efforts") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "VB") (:stem . "unify") (:form . "unify") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "access") (:form . "access") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "acquire") (:form . "acquiring") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "source") (:form . "sources") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "trivial") (:form . "trivial") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "prone") (:form . "prone") (:end . 158)\n  (:start . 153) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.253) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101366@unknown@formal@none@1@S@The PSI-MI XML data exchange format provided by the aforementioned databases was used to generate a local relational database of protein interactions.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PSI-MI") (:form . "PSI-MI") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "XML") (:form . "XML") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "exchange") (:form . "exchange") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "format") (:form . "format") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "aforementioned") (:form . "aforementioned")\n  (:end . 66) (:start . 52) (:id . 51))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "JJ") (:stem . "relational") (:form . "relational") (:end . 116)\n  (:start . 106) (:id . 59))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 149)\n  (:start . 137) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s4.254) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101367@unknown@formal@none@1@S@All entries were mapped to UniProt 33 by either relying on existing annotations from the source databases or by pair-wise sequence alignment to all UniProt proteins from the same species as the query protein.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "entry") (:form . "entries") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 23) (:start . 17)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "UniProt") (:form . "UniProt") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "VBG") (:stem . "rely") (:form . "relying") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "annotation") (:form . "annotations") (:end . 79)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 95)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "pair-wise") (:form . "pair-wise") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "UniProt") (:form . "UniProt") (:end . 155)\n  (:start . 148) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 164)\n  (:start . 156) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 169) (:start . 165)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 178) (:start . 174)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 186)\n  (:start . 179) (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 73))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 199)\n  (:start . 194) (:id . 74))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 207)\n  (:start . 200) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s4.255) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101368@unknown@formal@none@1@S@The direct sequence comparison was performed using pmatch, a very fast pairwise alignment algorithm developed by Richard Durbin (unpublished, source code available 34).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 50) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pmatch") (:form . "pmatch") (:end . 57)\n  (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fast") (:form . "fast") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "pairwise") (:form . "pairwise") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Richard") (:form . "Richard") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "NNP") (:stem . "Durbin") (:form . "Durbin") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 140)\n  (:start . 129) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 148)\n  (:start . 142) (:id . 64))\n ((:tag . "VBP") (:stem . "code") (:form . "code") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 163)\n  (:start . 154) (:id . 66))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.256) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101370@unknown@formal@none@1@S@To allow cross-species comparisons, the data were split into five distinct species sets: E. coli, S. cerevisiae, C. elegans, D. melanogaster and H. sapiens.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "allow") (:form . "allow") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cross-species") (:form . "cross-species")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "comparison") (:form . "comparisons") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "split") (:form . "split") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNS") (:stem . "set") (:form . "sets") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 111)\n  (:start . 101) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 123)\n  (:start . 116) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 140) (:start . 128) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 155)\n  (:start . 148) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s4.258) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101371@unknown@formal@none@1@S@It should be noted that the proportion of proteins for which an interaction is known varies greatly between the species, see Table 1.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 84) (:start . 79)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "vary") (:form . "varies") (:end . 91) (:start . 85)\n  (:id . 57))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 107)\n  (:start . 100) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "see") (:form . "see") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Table") (:form . "Table") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s4.259) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101372@unknown@formal@none@1@S@This might affect the results if there is a systematic bias on the composition of a protein interaction set.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "systematic") (:form . "systematic") (:end . 54)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 78)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 91)\n  (:start . 84) (:id . 58))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 103)\n  (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x4.260.1) (:span 5 10)))\n (:hscopes ((:id . :x4.260.1) (:span 5 29)))\n (:identifiers (:sid . :s4.260) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101373@unknown@formal@none@1@S@To prevent bias from multiple alternative versions of the same protein, all interacting proteins were mapped to reference proteomes as defined by Integr8 35, again using pmatch.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "bias") (:form . "bias") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "version") (:form . "versions") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "reference") (:form . "reference") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "NNS") (:stem . "proteome") (:form . "proteomes") (:end . 131)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 134) (:start . 132)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "integr8") (:form . "Integr8") (:end . 153)\n  (:start . 146) (:id . 65))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 67))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 169) (:start . 164)\n  (:id . 69))\n ((:tag . "NN") (:stem . "pmatch") (:form . "pmatch") (:end . 176)\n  (:start . 170) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s4.261) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101374@unknown@formal@none@1@S@An average of ≈ 16% of interaction entries were lost in the mapping process, either if no sequence was provided with the original entry or if no significant matching sequence could be found in Integr8.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "≈") (:form . "≈") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 48))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 34)\n  (:start . 23) (:id . 49))\n ((:tag . "NNS") (:stem . "entry") (:form . "entries") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 67)\n  (:start . 60) (:id . 55))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 75)\n  (:start . 68) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 83)\n  (:start . 77) (:id . 58))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 89) (:start . 87)\n  (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 98)\n  (:start . 90) (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 111)\n  (:start . 103) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 135)\n  (:start . 130) (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 138) (:start . 136)\n  (:id . 68))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 141) (:start . 139)\n  (:id . 69))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 144) (:start . 142)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 156)\n  (:start . 145) (:id . 71))\n ((:tag . "NN") (:stem . "matching") (:form . "matching") (:end . 165)\n  (:start . 157) (:id . 72))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 174)\n  (:start . 166) (:id . 73))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 180)\n  (:start . 175) (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 183) (:start . 181)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 189)\n  (:start . 184) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 192) (:start . 190)\n  (:id . 77))\n ((:tag . "NN") (:stem . "integr8") (:form . "Integr8") (:end . 200)\n  (:start . 193) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x4.262.1) (:span 142 144))\n  ((:id . :x4.262.2) (:span 87 89)))\n (:nscopes ((:id . :x4.262.1) (:span 142 200))\n  ((:id . :x4.262.2) (:span 87 135)))\n (:identifiers (:sid . :s4.262) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101375@unknown@formal@none@1@S@The total number of missing proteins will be lower, as several entries from different databases refer to the same sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "NNS") (:stem . "entry") (:form . "entries") (:end . 70)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 95)\n  (:start . 86) (:id . 57))\n ((:tag . "VBP") (:stem . "refer") (:form . "refer") (:end . 101)\n  (:start . 96) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 113) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 122)\n  (:start . 114) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s4.263) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101376@unknown@formal@none@1@S@iPfam@(((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 5) (:start . 0)\n  (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.264) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101377@unknown@formal@none@1@S@The iPfam database is derived from protein structures deposited in the PDB.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "deposit") (:form . "deposited") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pdb") (:form . "PDB") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.265) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101378@unknown@formal@none@1@S@Regions in every protein structure that match a Pfam domain are scanned for interactions with residues in another Pfam domain.@(((:tag . "NNS") (:stem . "region") (:form . "Regions") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "match") (:form . "match") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "scan") (:form . "scanned") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 88)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.266) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101380@unknown@formal@none@1@S@Every pair of Pfam families that are found to interact in a PDB structure are called an iPfam domain pair throughout the text.@(((:tag . "DT") (:stem . "every") (:form . "Every") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 73)\n  (:start . 64) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 84) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 93) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 116)\n  (:start . 106) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NN") (:stem . "text") (:form . "text") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.268) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101381@unknown@formal@none@1@S@Single Pfam families that are part of an iPfam domain pair are then called iPfam domains.@(((:tag . "JJ") (:stem . "single") (:form . "Single") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 74) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 88)\n  (:start . 81) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s4.269) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101382@unknown@formal@none@1@S@For example, in PDB entry 1k9a the two iPfam domains SH2 (Pfam accession PF00017) and Pkinase_Tyr (PF07714) interact, therefore they form an iPfam domain pair.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "1k9a") (:form . "1k9a") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 52)\n  (:start . 45) (:id . 52))\n ((:tag . "NN") (:stem . "sh2") (:form . "SH2") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Pfam") (:form . "Pfam") (:end . 62) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "accession") (:form . "accession") (:end . 72)\n  (:start . 63) (:id . 56))\n ((:tag . "NN") (:stem . "pf00017") (:form . "PF00017") (:end . 80)\n  (:start . 73) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Pkinase_Tyr") (:form . "Pkinase_Tyr") (:end . 97)\n  (:start . 86) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pf07714") (:form . "PF07714") (:end . 106)\n  (:start . 99) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "interact") (:form . "interact") (:end . 116)\n  (:start . 108) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 127)\n  (:start . 118) (:id . 66))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 132) (:start . 128)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 137) (:start . 133)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 140) (:start . 138)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 146)\n  (:start . 141) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 153)\n  (:start . 147) (:id . 71))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 158) (:start . 154)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s4.270) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101383@unknown@formal@none@1@S@In this study, iPfam version 21 was employed, containing 2837 iPfam domains, forming 4030 iPfam domain pairs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 20) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 56)\n  (:start . 46) (:id . 52))\n ((:tag . "CD") (:stem . "2837") (:form . "2837") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 75)\n  (:start . 68) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "form") (:form . "forming") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "CD") (:stem . "4030") (:form . "4030") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.271) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101384@unknown@formal@none@1@S@Figure 5 shows the species distribution of iPfam domain pairs.@(((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s4.272) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101385@unknown@formal@none@1@S@H. sapiens, E. coli and S. cerevisiae are clearly over-represented compared to the other 1113 species with less than 179 complex structures.@(((:tag . "NNP") (:stem . "H.") (:form . "H.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "FW") (:stem . "e.") (:form . "E.") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "FW") (:stem . "coli") (:form . "coli") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "FW") (:stem . "s.") (:form . "S.") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "FW") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 37)\n  (:start . 27) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "JJ") (:stem . "over-represented") (:form . "over-represented")\n  (:end . 66) (:start . 50) (:id . 52))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "1113") (:form . "1113") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "CD") (:stem . "179") (:form . "179") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "complex") (:form . "complex") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s4.273) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101386@unknown@formal@none@1@S@Some iPfam domain pairs are seen to form interactions between distinct peptide chains in the structure (interchain), while others form an interaction between two distinct domains within the same chain (intrachain).@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 53)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "peptide") (:form . "peptide") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NNS") (:stem . "chain") (:form . "chains") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 102)\n  (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interchain") (:form . "interchain") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 149)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 157)\n  (:start . 150) (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 178)\n  (:start . 171) (:id . 70))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 194) (:start . 190)\n  (:id . 73))\n ((:tag . "NN") (:stem . "chain") (:form . "chain") (:end . 200)\n  (:start . 195) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 75))\n ((:tag . "NN") (:stem . "intrachain") (:form . "intrachain") (:end . 212)\n  (:start . 202) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s4.274) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101387@unknown@formal@none@1@S@In iPfam version 21, there are 3407 interchain and 1171 intrachain domain pairs, which means that 548 domain pairs mediate both inter- and intrachain interactions.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "CD") (:stem . "3407") (:form . "3407") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "interchain") (:form . "interchain") (:end . 46)\n  (:start . 36) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1171") (:form . "1171") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "CD") (:stem . "548") (:form . "548") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 108)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . "VBP") (:stem . "mediate") (:form . "mediate") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "inter-") (:form . "inter-") (:end . 134)\n  (:start . 128) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 149)\n  (:start . 139) (:id . 67))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 162)\n  (:start . 150) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s4.275) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101388@unknown@formal@none@1@S@In this analysis, both types of domain interactions were used equivalently, assuming that intrachain interactions can become interchain interactions and vice-versa as a result of a gene-fission/fusion events.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 51)\n  (:start . 39) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "equivalently") (:form . "equivalently") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "assume") (:form . "assuming") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "intrachain") (:form . "intrachain") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "VB") (:stem . "become") (:form . "become") (:end . 124)\n  (:start . 118) (:id . 60))\n ((:tag . "JJ") (:stem . "interchain") (:form . "interchain") (:end . 135)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 148)\n  (:start . 136) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "vice-versa") (:form . "vice-versa") (:end . 163)\n  (:start . 153) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 66))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 175)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene-fission/fusion")\n  (:form . "gene-fission/fusion") (:end . 200) (:start . 181) (:id . 70))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 207)\n  (:start . 201) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x4.276.1) (:span 114 117))\n  ((:id . :x4.276.2) (:span 76 84)))\n (:hscopes ((:id . :x4.276.1) (:span 114 207))\n  ((:id . :x4.276.2) (:span 76 207)))\n (:identifiers (:sid . :s4.276) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101390@unknown@formal@none@1@S@Species distribution of iPfam domain pairs.@(((:tag . "NNP") (:stem . "Species") (:form . "Species") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 29) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.278) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101391@unknown@formal@none@1@S@This pie chart shows how many iPfam domain pairs were found in PDB structures from each species.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pie") (:form . "pie") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "chart") (:form . "chart") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PDB") (:form . "PDB") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 77)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s4.279) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101392@unknown@formal@none@1@S@The total number is larger than the 4030 unique iPfam pairs in the database because an iPfam pair can be found in structures from several species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJR") (:stem . "large") (:form . "larger") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "4030") (:form . "4030") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 83)\n  (:start . 76) (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ipfam") (:form . "iPfam") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 124)\n  (:start . 114) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 145)\n  (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s4.280) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101393@unknown@formal@none@1@S@Filtering@(((:tag . "NNP") (:stem . "Filtering") (:form . "Filtering") (:end . 9)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s4.281) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101394@unknown@formal@none@1@S@There are many types of experiments used to derive protein interactions, with different properties and error rates.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 35)\n  (:start . 24) (:id . 47))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "derive") (:form . "derive") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 71)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.282) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101395@unknown@formal@none@1@S@For this analysis, solely the properties of physically interacting proteins is of interest.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "solely") (:form . "solely") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "VBG") (:stem . "interact") (:form . "interacting") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s4.283) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101396@unknown@formal@none@1@S@Therefore, only interactions between exactly two proteins per experiment were considered.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 88)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s4.284) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101397@unknown@formal@none@1@S@That means all protein complex data that were derived by co-purification methods were removed, unless a particular experiment had identified exactly two binding partners.@(((:tag . "DT") (:stem . "that") (:form . "That") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "co-purification") (:form . "co-purification")\n  (:end . 72) (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "method") (:form . "methods") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 125)\n  (:start . 115) (:id . 60))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 140)\n  (:start . 130) (:id . 62))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 148)\n  (:start . 141) (:id . 63))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 152) (:start . 149)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "NNS") (:stem . "partner") (:form . "partners") (:end . 169)\n  (:start . 161) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s4.285) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101398@unknown@formal@none@1@S@All genetic interactions were also removed.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s4.286) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101400@unknown@formal@none@1@S@Randomised protein interaction networks with identical degree distributions were generated from the original filtered experimental interaction data for each species.@(((:tag . "VBN") (:stem . "randomise") (:form . "Randomised") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 30)\n  (:start . 19) (:id . 44))\n ((:tag . "NNS") (:stem . "network") (:form . "networks") (:end . 39)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 54)\n  (:start . 45) (:id . 47))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 61)\n  (:start . 55) (:id . 48))\n ((:tag . "NNS") (:stem . "distribution") (:form . "distributions")\n  (:end . 75) (:start . 62) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 90)\n  (:start . 81) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 108)\n  (:start . 100) (:id . 54))\n ((:tag . "VBN") (:stem . "filter") (:form . "filtered") (:end . 117)\n  (:start . 109) (:id . 55))\n ((:tag . "JJ") (:stem . "experimental") (:form . "experimental") (:end . 130)\n  (:start . 118) (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 142)\n  (:start . 131) (:id . 57))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 147)\n  (:start . 143) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 59))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 156) (:start . 152)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 164)\n  (:start . 157) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s4.288) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101401@unknown@formal@none@1@S@In each randomisation step, a mapping is created that assigns every node a randomly chosen replacement node.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "randomisation") (:form . "randomisation")\n  (:end . 21) (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mapping") (:form . "mapping") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "assign") (:form . "assigns") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "DT") (:stem . "every") (:form . "every") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "NN") (:stem . "replacement") (:form . "replacement") (:end . 102)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.289) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101402@unknown@formal@none@1@S@In this way the edges of the network remain in place, while the nodes are shuffled randomly.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "edge") (:form . "edges") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "VBP") (:stem . "remain") (:form . "remain") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 59) (:start . 54)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 69) (:start . 64)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "shuffle") (:form . "shuffled") (:end . 82)\n  (:start . 74) (:id . 58))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 91)\n  (:start . 83) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s4.290) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101403@unknown@formal@none@1@S@It should be noted that the degree distribution per node is not maintained.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "note") (:form . "noted") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "degree") (:form . "degree") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 47)\n  (:start . 35) (:id . 49))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "node") (:form . "node") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "maintain") (:form . "maintained") (:end . 74)\n  (:start . 64) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:ncues ((:id . :x4.291.1) (:span 60 63)))\n (:nscopes ((:id . :x4.291.1) (:span 60 74)))\n (:identifiers (:sid . :s4.291) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101404@unknown@formal@none@1@S@Instead, this behaviour simulates a network with a high false positive rate.@(((:tag . "RB") (:stem . "instead") (:form . "Instead") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "behaviour") (:form . "behaviour") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "simulate") (:form . "simulates") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "network") (:form . "network") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "positive") (:form . "positive") (:end . 70)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s4.292) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101405@unknown@formal@none@1@S@P values@(((:tag . "NN") (:stem . "p") (:form . "P") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 8) (:start . 2)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s4.293) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101406@unknown@formal@none@1@S@P values for observations x were calculated as P(X ≥ x) = f(x; μ, σ), where f(x; μ, σ) is the probability density function of the normal distribution with mean μ and standard deviation σ.@(((:tag . "NN") (:stem . "p") (:form . "P") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 25)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "calculate") (:form . "calculated") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "P(X") (:form . "P(X") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "≥") (:form . "≥") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 57) (:start . 56)\n  (:id . 54))\n ((:tag . "FW") (:stem . "f(x") (:form . "f(x") (:end . 61) (:start . 58)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . "SYM") (:stem . "μ") (:form . "μ") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "σ") (:form . "σ") (:end . 67) (:start . 66)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 61))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 75) (:start . 70)\n  (:id . 62))\n ((:tag . "NN") (:stem . "f(x") (:form . "f(x") (:end . 79) (:start . 76)\n  (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 80) (:start . 79)\n  (:id . 64))\n ((:tag . "SYM") (:stem . "μ") (:form . "μ") (:end . 82) (:start . 81)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "σ") (:form . "σ") (:end . 85) (:start . 84)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 89) (:start . 87)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 70))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 105)\n  (:start . 94) (:id . 71))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 113)\n  (:start . 106) (:id . 72))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 122)\n  (:start . 114) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 136)\n  (:start . 130) (:id . 76))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 149)\n  (:start . 137) (:id . 77))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "mean") (:form . "mean") (:end . 159) (:start . 155)\n  (:id . 79))\n ((:tag . "NN") (:stem . "μ") (:form . "μ") (:end . 161) (:start . 160)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 174)\n  (:start . 166) (:id . 82))\n ((:tag . "NN") (:stem . "deviation") (:form . "deviation") (:end . 184)\n  (:start . 175) (:id . 83))\n ((:tag . "NN") (:stem . "σ") (:form . "σ") (:end . 186) (:start . 185)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s4.294) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101407@unknown@formal@none@1@S@μ and σ are estimated through the randomisation experiments.@(((:tag . "NNP") (:stem . "μ") (:form . "μ") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 5) (:start . 2)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "σ") (:form . "σ") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 11) (:start . 8)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 21)\n  (:start . 12) (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "randomisation") (:form . "randomisation")\n  (:end . 47) (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s4.295) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101408@unknown@formal@none@1@S@The density function thus provides the probability that a value less than or equal to x is observed by chance, given the distribution estimated by a random resampling method.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "x") (:form . "x") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 116)\n  (:start . 111) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 133)\n  (:start . 121) (:id . 65))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 143)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 146) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "random") (:form . "random") (:end . 155)\n  (:start . 149) (:id . 69))\n ((:tag . "VBG") (:stem . "resample") (:form . "resampling") (:end . 166)\n  (:start . 156) (:id . 70))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 173)\n  (:start . 167) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s4.296) (:did . :1471-2105-8-259)\n  (:did-type . :bmc_id) (:dtype . :|Biological_full_article|)\n  (:dpart . :|Text|)))@oe@9-2-2011
5101410@unknown@formal@none@1@S@Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "E3") (:form . "E3") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ubiquitin") (:form . "Ubiquitin") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "Ligases") (:form . "Ligases") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "Have") (:form . "Have") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Complementary") (:form . "Complementary")\n  (:end . 52) (:start . 39) (:id . 48))\n ((:tag . "NNPS") (:stem . "Function") (:form . "Functions") (:end . 62)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Delta") (:form . "Delta") (:end . 89) (:start . 84)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Serrate") (:form . "Serrate") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NNP") (:stem . "Signaling") (:form . "Signaling") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 125)\n  (:start . 115) (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.1) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5101411@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s5.2) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101412@unknown@formal@none@1@S@Signaling by the Notch ligands Delta (Dl) and Serrate (Ser) regulates a wide variety of essential cell-fate decisions during animal development.@(((:tag . "NN") (:stem . "signaling") (:form . "Signaling") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "Delta") (:form . "Delta") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Serrate") (:form . "Serrate") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 59) (:start . 58)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 69)\n  (:start . 60) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "wide") (:form . "wide") (:end . 76) (:start . 72)\n  (:id . 58))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 84)\n  (:start . 77) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 97)\n  (:start . 88) (:id . 61))\n ((:tag . "JJ") (:stem . "cell-fate") (:form . "cell-fate") (:end . 107)\n  (:start . 98) (:id . 62))\n ((:tag . "NNS") (:stem . "decision") (:form . "decisions") (:end . 117)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 124)\n  (:start . 118) (:id . 64))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 131)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 143)\n  (:start . 132) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s5.3) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101413@unknown@formal@none@1@S@Two distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), have been shown to regulate Dl signaling in Drosophila melanogaster and Danio rerio, respectively.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "ligas") (:form . "ligases") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Neuralized") (:form . "Neuralized") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mind") (:form . "Mind") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bomb") (:form . "bomb") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 78) (:start . 74)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 83) (:start . 79)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 89) (:start . 84)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 62))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 101)\n  (:start . 93) (:id . 63))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 104) (:start . 102)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 114)\n  (:start . 105) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 128)\n  (:start . 118) (:id . 67))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 141) (:start . 129) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Danio") (:form . "Danio") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 157)\n  (:start . 152) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 72))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 171)\n  (:start . 159) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s5.4) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101414@unknown@formal@none@1@S@While the neur and mib genes are evolutionarily conserved, their respective roles in the context of a single organism have not yet been examined.@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mib") (:form . "mib") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "RB") (:stem . "evolutionarily") (:form . "evolutionarily")\n  (:end . 47) (:start . 33) (:id . 49))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 64)\n  (:start . 59) (:id . 52))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 144)\n  (:start . 136) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x5.5.1) (:span 123 126)))\n (:nscopes ((:id . :x5.5.1) (:span 59 144)))\n (:identifiers (:sid . :s5.5) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101415@unknown@formal@none@1@S@We show here that the Drosophila mind bomb (D-mib) gene regulates a subset of Notch signaling events, including wing margin specification, leg segmentation, and vein determination, that are distinct from those events requiring neur activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 32)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "mind") (:form . "mind") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "bomb") (:form . "bomb") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 55) (:start . 51)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 65)\n  (:start . 56) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 74)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 83) (:start . 78)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 59))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 100)\n  (:start . 94) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 111)\n  (:start . 102) (:id . 62))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 116) (:start . 112)\n  (:id . 63))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 137) (:start . 124) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "leg") (:form . "leg") (:end . 142) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "segmentation") (:form . "segmentation") (:end . 155)\n  (:start . 143) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 165) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 179) (:start . 166) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 74))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 189) (:start . 186)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 198)\n  (:start . 190) (:id . 76))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 203) (:start . 199)\n  (:id . 77))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 209)\n  (:start . 204) (:id . 78))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 216)\n  (:start . 210) (:id . 79))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 226)\n  (:start . 217) (:id . 80))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 231) (:start . 227)\n  (:id . 81))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 240)\n  (:start . 232) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s5.6) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101416@unknown@formal@none@1@S@D-mib also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting that D-mib regulates Dl signaling.@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "modulate") (:form . "modulates") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "lateral") (:form . "lateral") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "neur-") (:form . "neur-") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dl-dependent") (:form . "Dl-dependent") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 104)\n  (:start . 99) (:id . 57))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 117) (:start . 115)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x5.7.1) (:span 83 93)))\n (:hscopes ((:id . :x5.7.1) (:span 83 127)))\n (:identifiers (:sid . :s5.7) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101417@unknown@formal@none@1@S@During wing development, expression of D-mib in dorsal cells appears to be necessary and sufficient for wing margin specification, indicating that D-mib also regulates Ser signaling.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 84)\n  (:start . 75) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 99)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 108) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 129) (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 152)\n  (:start . 147) (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 157) (:start . 153)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 167)\n  (:start . 158) (:id . 67))\n ((:tag . "NN") (:stem . "ser") (:form . "Ser") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 181)\n  (:start . 172) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x5.8.1) (:span 131 146)) ((:id . :x5.8.2) (:span 61 68)))\n (:hscopes ((:id . :x5.8.1) (:span 131 181)) ((:id . :x5.8.2) (:span 25 129)))\n (:identifiers (:sid . :s5.8) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101418@unknown@formal@none@1@S@Moreover, the activity of the D-mib gene is required for the endocytosis of Ser in wing imaginal disc cells.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 72)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 79) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 87) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "disc") (:form . "disc") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s5.9) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101420@unknown@formal@none@1@S@We conclude that D-mib and Neur are two structurally distinct proteins that have similar molecular activities but distinct developmental functions in Drosophila.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 52)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 88)\n  (:start . 81) (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 98)\n  (:start . 89) (:id . 56))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 109)\n  (:start . 99) (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 122)\n  (:start . 114) (:id . 59))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 136) (:start . 123) (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 146)\n  (:start . 137) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 160)\n  (:start . 150) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.11) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101421@unknown@formal@none@1@S@Introduction@(((:tag . "NN") (:stem . "introduction") (:form . "Introduction") (:end . 12)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s5.12) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101422@unknown@formal@none@1@S@Cell-to-cell signaling mediated by receptors of the Notch (N) family has been implicated in various developmental decisions in organisms ranging from nematodes to mammals [1].@(((:tag . "JJ") (:stem . "cell-to-cell") (:form . "Cell-to-cell") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 31)\n  (:start . 23) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 44)\n  (:start . 35) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Notch") (:form . "Notch") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 113) (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "decision") (:form . "decisions") (:end . 123)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "VBG") (:stem . "range") (:form . "ranging") (:end . 144)\n  (:start . 137) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 149) (:start . 145)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "nematode") (:form . "nematodes") (:end . 159)\n  (:start . 150) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 170)\n  (:start . 163) (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.13) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101423@unknown@formal@none@1@S@N is well-known for its role in lateral inhibition, a key patterning process that organizes the regular spacing of distinct cell types within groups of equipotent cells.@(((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 4) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "well-known") (:form . "well-known") (:end . 15)\n  (:start . 5) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "lateral") (:form . "lateral") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "patterning") (:form . "patterning") (:end . 68)\n  (:start . 58) (:id . 54))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "organize") (:form . "organizes") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "regular") (:form . "regular") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "NN") (:stem . "spacing") (:form . "spacing") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 134)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 141)\n  (:start . 135) (:id . 65))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "equipotent") (:form . "equipotent") (:end . 162)\n  (:start . 152) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s5.14) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101424@unknown@formal@none@1@S@Additionally, N mediates inductive signaling between cells with distinct identities.@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "mediate") (:form . "mediates") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "inductive") (:form . "inductive") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 52)\n  (:start . 45) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "identity") (:form . "identities") (:end . 83)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s5.15) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101425@unknown@formal@none@1@S@In both signaling events, N signals via a conserved mechanism that involves the cleavage and release from the membrane of the N intracellular domain that acts as a transcriptional co-activator for DNA-binding proteins of the CBF1/Suppressor of Hairless/Lag-2 (CSL) family [2].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 105) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 118)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 141) (:start . 128) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 148)\n  (:start . 142) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 153) (:start . 149)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 158) (:start . 154)\n  (:id . 68))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 179) (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "co-activator") (:form . "co-activator") (:end . 192)\n  (:start . 180) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 208)\n  (:start . 197) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 217)\n  (:start . 209) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 220) (:start . 218)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 224) (:start . 221)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "CBF1/Suppressor") (:form . "CBF1/Suppressor")\n  (:end . 240) (:start . 225) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Hairless/Lag-2") (:form . "Hairless/Lag-2")\n  (:end . 258) (:start . 244) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 260) (:start . 259)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "CSL") (:form . "CSL") (:end . 263) (:start . 260)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 264) (:start . 263)\n  (:id . 83))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 271)\n  (:start . 265) (:id . 84))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 273) (:start . 272)\n  (:id . 85))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 274) (:start . 273)\n  (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 275) (:start . 274)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 276) (:start . 275)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s5.16) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101426@unknown@formal@none@1@S@Two transmembrane ligands of N are known in Drosophila, Delta (Dl) and Serrate (Ser) [3].@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transmembrane") (:form . "transmembrane")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Delta") (:form . "Delta") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Serrate") (:form . "Serrate") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 86) (:start . 85)\n  (:id . 61))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 87) (:start . 86)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 88) (:start . 87)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.17) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101427@unknown@formal@none@1@S@Dl and Ser have distinct functions.@(((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 24)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 35) (:start . 34)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s5.18) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101428@unknown@formal@none@1@S@For instance, Dl (but not Ser) is essential for lateral inhibition during early neurogenesis in the embryo [4].@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 21) (:start . 18)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 29) (:start . 26)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 43)\n  (:start . 34) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "lateral") (:form . "lateral") (:end . 55)\n  (:start . 48) (:id . 54))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 66)\n  (:start . 56) (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "neurogenesis") (:form . "neurogenesis") (:end . 92)\n  (:start . 80) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "embryo") (:form . "embryo") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x5.19.1) (:span 22 25)))\n (:nscopes ((:id . :x5.19.1) (:span 22 30)))\n (:identifiers (:sid . :s5.19) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101430@unknown@formal@none@1@S@Some developmental decisions, however, require the activity of both genes: Dl and Ser are both required for the specification of wing margin cells during imaginal development [6,7,8,9,10].@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 18) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "decision") (:form . "decisions") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 37)\n  (:start . 30) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 107) (:start . 104)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 125) (:start . 112) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 140)\n  (:start . 134) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 162)\n  (:start . 154) (:id . 69))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 174)\n  (:start . 163) (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 176) (:start . 175)\n  (:id . 71))\n ((:tag . "CD") (:stem . "6,7,8,9,10") (:form . "6,7,8,9,10") (:end . 186)\n  (:start . 176) (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s5.21) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101431@unknown@formal@none@1@S@These different requirements for Dl and Ser appear to primarily result from their non-overlapping expression patterns rather than from distinct signaling properties.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "primarily") (:form . "primarily") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 81)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "non-overlapping") (:form . "non-overlapping")\n  (:end . 97) (:start . 82) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 129) (:start . 125)\n  (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 134) (:start . 130)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 143)\n  (:start . 135) (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 153)\n  (:start . 144) (:id . 62))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 164)\n  (:start . 154) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x5.22.2) (:span 44 50)))\n (:ncues ((:id . :x5.22.1) (:span 118 129)))\n (:hscopes ((:id . :x5.22.2) (:span 0 164)))\n (:nscopes ((:id . :x5.22.1) (:span 118 164)))\n (:identifiers (:sid . :s5.22) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101432@unknown@formal@none@1@S@Consistent with this interpretation, Dl and Ser have been proposed to act redundantly in the sensory bristle lineage where they are co-expressed ([11]; note, however, that results from another study have indicated a non-redundant function for Dl in the bristle lineage [12]).@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "RB") (:stem . "redundantly") (:form . "redundantly") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "bristle") (:form . 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"NN") (:stem . "note") (:form . "note") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 71))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 165)\n  (:start . 158) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 171) (:start . 167)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 179)\n  (:start . 172) (:id . 75))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 76))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 192)\n  (:start . 185) (:id . 77))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 198)\n  (:start . 193) (:id . 78))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 203) (:start . 199)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 213)\n  (:start . 204) (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 215) (:start . 214)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "non-redundant") (:form . "non-redundant")\n  (:end . 229) (:start . 216) (:id . 82))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 238)\n  (:start . 230) (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 242) (:start . 239)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 245) (:start . 243)\n  (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 248) (:start . 246)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 252) (:start . 249)\n  (:id . 87))\n ((:tag . "NN") (:stem . "bristle") (:form . "bristle") (:end . 260)\n  (:start . 253) (:id . 88))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 268)\n  (:start . 261) (:id . 89))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 270) (:start . 269)\n  (:id . 90))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 272) (:start . 270)\n  (:id . 91))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 273) (:start . 272)\n  (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 274) (:start . 273)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x5.23.1) (:span 58 66)))\n (:hscopes ((:id . :x5.23.1) (:span 37 144)))\n (:identifiers (:sid . :s5.23) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101433@unknown@formal@none@1@S@Furthermore, Dl and Ser appear to be partially interchangeable because the forced expression of Ser can partially rescue the Dl neurogenic phenotype [13].@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "JJ") (:stem . "interchangeable") (:form . "interchangeable")\n  (:end . 62) (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "force") (:form . "forced") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 99) (:start . 96)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 120)\n  (:start . 114) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "dl") (:form . "Dl") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "neurogenic") (:form . "neurogenic") (:end . 138)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 148)\n  (:start . 139) (:id . 64))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 153) (:start . 152)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x5.24.1) (:span 24 30)))\n (:hscopes ((:id . :x5.24.1) (:span 13 62)))\n (:identifiers (:sid . :s5.24) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101434@unknown@formal@none@1@S@Additionally, the ectopic expression of Dl can partially rescue the Ser wing phenotype [14].@(((:tag . "RB") (:stem . "additionally") (:form . "Additionally") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.25) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101435@unknown@formal@none@1@S@The notion that Dl and Ser have similar signaling properties has, however, recently been challenged by the observation that human homologs of Dl and Ser have distinct instructive signaling activity [15].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "notion") (:form . "notion") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 39)\n  (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "challenge") (:form . "challenged") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 118)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 129)\n  (:start . 124) (:id . 63))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 138)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 152) (:start . 149)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . "JJ") (:stem . "instructive") (:form . "instructive") (:end . 178)\n  (:start . 167) (:id . 71))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 188)\n  (:start . 179) (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 197)\n  (:start . 189) (:id . 73))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 199) (:start . 198)\n  (:id . 74))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 201) (:start . 199)\n  (:id . 75))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 202) (:start . 201)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s5.26) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101436@unknown@formal@none@1@S@Endocytosis has recently emerged as a key mechanism regulating the signaling activity of Dl.@(((:tag . "NNP") (:stem . "Endocytosis") (:form . "Endocytosis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 32)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 76)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.27) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101437@unknown@formal@none@1@S@First, clonal analysis in Drosophila has suggested that dynamin-dependent endocytosis is required not only in signal-receiving cells but also in signal-sending cells to promote N activation [16].@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dynamin-dependent") (:form . "dynamin-dependent")\n  (:end . 73) (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "signal-receiving") (:form . "signal-receiving")\n  (:end . 126) (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 132)\n  (:start . 127) (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 136) (:start . 133)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 141) (:start . 137)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "signal-sending") (:form . "signal-sending")\n  (:end . 159) (:start . 145) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 168) (:start . 166)\n  (:id . 65))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 176)\n  (:start . 169) (:id . 66))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 178) (:start . 177)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 189)\n  (:start . 179) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 191) (:start . 190)\n  (:id . 69))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 193) (:start . 191)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x5.28.1) (:span 41 50)))\n (:hscopes ((:id . :x5.28.1) (:span 41 189)))\n (:identifiers (:sid . :s5.28) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101438@unknown@formal@none@1@S@Second, mutant Dl proteins that are endocytosis defective exhibit reduced signaling activity [17].@(((:tag . "JJ") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "exhibit") (:form . "exhibit") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.29) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101440@unknown@formal@none@1@S@Ubiquitin is a 76-amino-acid polypeptide that is covalently linked to substrates in a multi-step process that involves a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin–protein ligase (E3).@(((:tag . "NNP") (:stem . "Ubiquitin") (:form . "Ubiquitin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "76-amino-acid") (:form . "76-amino-acid")\n  (:end . 28) (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "polypeptide") (:form . "polypeptide") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "RB") (:stem . "covalently") (:form . "covalently") (:end . 59)\n  (:start . 49) (:id . 49))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 66) (:start . 60)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multi-step") (:form . "multi-step") (:end . 96)\n  (:start . 86) (:id . 55))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ubiquitin-activating")\n  (:form . "ubiquitin-activating") (:end . 141) (:start . 121) (:id . 60))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 148)\n  (:start . 142) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "E1") (:form . "E1") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 156) (:start . 155)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ubiquitin-conjugating")\n  (:form . "ubiquitin-conjugating") (:end . 178) (:start . 157) (:id . 67))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 185)\n  (:start . 179) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "E2") (:form . "E2") (:end . 189) (:start . 187)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 191) (:start . 190)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ubiquitin–protein") (:form . "ubiquitin–protein")\n  (:end . 215) (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 222)\n  (:start . 216) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 224) (:start . 223)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "E3") (:form . "E3") (:end . 226) (:start . 224)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 227) (:start . 226)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s5.31) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101441@unknown@formal@none@1@S@E3s recognize specific substrates and catalyze the transfer of ubiquitin to the protein substrate.@(((:tag . "NNS") (:stem . "e3") (:form . "E3s") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "VB") (:stem . "catalyze") (:form . "catalyze") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transfer") (:form . "transfer") (:end . 59)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.32) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101442@unknown@formal@none@1@S@Ubiquitin was first identified as a tag for proteins destined for degradation.@(((:tag . "NNP") (:stem . "Ubiquitin") (:form . "Ubiquitin") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "tag") (:form . "tag") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBN") (:stem . "destine") (:form . "destined") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 77)\n  (:start . 66) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.33) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101443@unknown@formal@none@1@S@More recently, ubiquitin has also been shown to serve as a signal for endocytosis [26,27].@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 81)\n  (:start . 70) (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "CD") (:stem . "26,27") (:form . "26,27") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 89) (:start . 88)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.34) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101444@unknown@formal@none@1@S@Mib in D. rerio and Neur in Drosophila and Xenopus have been shown to associate with Dl, regulate Dl ubiquitination, and promote its endocytosis [18,19,20,22,25,28].@(((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 38)\n  (:start . 28) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Xenopus") (:form . "Xenopus") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 66) (:start . 61)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 55))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "regulate") (:form . "regulate") (:end . 97)\n  (:start . 89) (:id . 60))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 115) (:start . 101) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 144)\n  (:start . 133) (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 146) (:start . 145)\n  (:id . 68))\n ((:tag . "CD") (:stem . "18,19,20,22,25,28") (:form . "18,19,20,22,25,28")\n  (:end . 163) (:start . 146) (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 164) (:start . 163)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.35) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101445@unknown@formal@none@1@S@Moreover, genetic and transplantation studies have indicated that both Neur and Mib act in a non-autonomous manner [18,21,22,23,25,29], indicating that endocytosis of Dl is associated with increased Dl signaling activity.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "transplantation") (:form . "transplantation")\n  (:end . 37) (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 45)\n  (:start . 38) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "non-autonomous") (:form . "non-autonomous")\n  (:end . 107) (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 116) (:start . 115)\n  (:id . 60))\n ((:tag . "CD") (:stem . "18,21,22,23,25,29") (:form . "18,21,22,23,25,29")\n  (:end . 133) (:start . 116) (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 134) (:start . 133)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 163)\n  (:start . 152) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 169) (:start . 167)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 172) (:start . 170)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 183)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 198)\n  (:start . 189) (:id . 72))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 211)\n  (:start . 202) (:id . 74))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 220)\n  (:start . 212) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x5.36.1) (:span 136 151)) ((:id . :x5.36.2) (:span 51 65)))\n (:hscopes ((:id . :x5.36.1) (:span 136 220))\n  ((:id . :x5.36.2) (:span 51 220)))\n (:identifiers (:sid . :s5.36) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101446@unknown@formal@none@1@S@Finally, epsin, a regulator of endocytosis that contains a ubiquitin-interacting motif and that is known in Drosophila as Liquid facet, is essential for Dl signaling [30,31].@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "epsin") (:form . "epsin") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 42)\n  (:start . 31) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ubiquitin-interacting")\n  (:form . "ubiquitin-interacting") (:end . 80) (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 118)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Liquid") (:form . "Liquid") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "facet") (:form . "facet") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 148)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 165)\n  (:start . 156) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 167) (:start . 166)\n  (:id . 70))\n ((:tag . "CD") (:stem . "30,31") (:form . "30,31") (:end . 172)\n  (:start . 167) (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s5.37) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101447@unknown@formal@none@1@S@In one study, Liquid facet was proposed to target Dl to an endocytic recycling compartment, suggesting that recycling of Dl may be required for signaling.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Liquid") (:form . "Liquid") (:end . 20)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "facet") (:form . "facet") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VB") (:stem . "target") (:form . "target") (:end . 49)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "dl") (:form . "Dl") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "endocytic") (:form . "endocytic") (:end . 68)\n  (:start . 59) (:id . 55))\n ((:tag . "VBG") (:stem . "recycle") (:form . "recycling") (:end . 78)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 102)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "recycle") (:form . "recycling") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 139)\n  (:start . 131) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 153)\n  (:start . 144) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x5.38.1) (:span 124 127)) ((:id . :x5.38.2) (:span 92 102))\n  ((:id . :x5.38.3) (:span 31 39)))\n (:hscopes ((:id . :x5.38.1) (:span 108 153))\n  ((:id . :x5.38.2) (:span 92 153)) ((:id . :x5.38.3) (:span 14 153)))\n (:identifiers (:sid . :s5.38) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101448@unknown@formal@none@1@S@Accordingly, signaling would not be linked directly to endocytosis, but endocytosis would be prerequisite for signaling [30].@(((:tag . "RB") (:stem . "accordingly") (:form . "Accordingly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 42) (:start . 36)\n  (:id . 48))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 83)\n  (:start . 72) (:id . 54))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "prerequisite") (:form . "prerequisite") (:end . 105)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x5.39.1) (:span 84 89)) ((:id . :x5.39.2) (:span 23 28)))\n (:ncues ((:id . :x5.39.3) (:span 29 32)))\n (:hscopes ((:id . :x5.39.1) (:span 84 119)) ((:id . :x5.39.2) (:span 13 66)))\n (:nscopes ((:id . :x5.39.3) (:span 13 66)))\n (:identifiers (:sid . :s5.39) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101450@unknown@formal@none@1@S@Also, whether the signaling activity of Ser is similarly regulated by endocytosis is not known.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 56)\n  (:start . 47) (:id . 51))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x5.41.2) (:span 85 94)) ((:id . :x5.41.1) (:span 6 13)))\n (:hscopes ((:id . :x5.41.2) (:span 6 81)) ((:id . :x5.41.1) (:span 6 94)))\n (:identifiers (:sid . :s5.41) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101451@unknown@formal@none@1@S@Neur and Mib proteins completely differ in primary structure.@(((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 61) (:start . 60)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.42) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101452@unknown@formal@none@1@S@Drosophila Neur is a 754-amino-acid protein that contains two conserved Neur homology repeats of unknown function and one C-terminal catalytic really interesting new gene (RING) domain.@(((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "754-amino-acid") (:form . "754-amino-acid")\n  (:end . 35) (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 58))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 132)\n  (:start . 122) (:id . 60))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 142)\n  (:start . 133) (:id . 61))\n ((:tag . "RB") (:stem . "really") (:form . "really") (:end . 149)\n  (:start . 143) (:id . 62))\n ((:tag . "JJ") (:stem . "interesting") (:form . "interesting") (:end . 161)\n  (:start . 150) (:id . 63))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 165) (:start . 162)\n  (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 170) (:start . 166)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 66))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 176) (:start . 172)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 184)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s5.43) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101453@unknown@formal@none@1@S@D. rerio Mib (also known as DIP-1 in the mouse [32]) is a 1,030-amino-acid protein with one ZZ zinc finger domain surrounded by two Mib/HERC2 domains, two Mib repeats, eight ankyrin repeats, two atypical RING domains, and one C-terminal catalytic RING domain.@(((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dip-1") (:form . "DIP-1") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 46) (:start . 41)\n  (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 50) (:start . 48)\n  (:id . 54))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 51) (:start . 50)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "1,030-amino-acid") (:form . "1,030-amino-acid")\n  (:end . 74) (:start . 58) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 82)\n  (:start . 75) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 87) (:start . 83)\n  (:id . 61))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 91) (:start . 88)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "ZZ") (:form . "ZZ") (:end . 94) (:start . 92)\n  (:id . 63))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 99) (:start . 95)\n  (:id . 64))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 106)\n  (:start . 100) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 113)\n  (:start . 107) (:id . 66))\n ((:tag . "VBN") (:stem . "surround") (:form . "surrounded") (:end . 124)\n  (:start . 114) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 127) (:start . 125)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 131) (:start . 128)\n  (:id . 69))\n ((:tag . "NN") (:stem . "mib/herc2") (:form . "Mib/HERC2") (:end . 141)\n  (:start . 132) (:id . 70))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 149)\n  (:start . 142) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 72))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 154) (:start . 151)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 158) (:start . 155)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 166)\n  (:start . 159) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 76))\n ((:tag . "CD") (:stem . "eight") (:form . "eight") (:end . 173)\n  (:start . 168) (:id . 77))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 181)\n  (:start . 174) (:id . 78))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 189)\n  (:start . 182) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 80))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 194) (:start . 191)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 203)\n  (:start . 195) (:id . 82))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 208) (:start . 204)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 216)\n  (:start . 209) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 217) (:start . 216)\n  (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 221) (:start . 218)\n  (:id . 86))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 225) (:start . 222)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 236)\n  (:start . 226) (:id . 88))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 246)\n  (:start . 237) (:id . 89))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 251) (:start . 247)\n  (:id . 90))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 258)\n  (:start . 252) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 92)))@@@1@51@((:identifiers (:sid . :s5.44) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101454@unknown@formal@none@1@S@Both genes have been conserved from flies to mammals [18,19,33,34].@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "18,19,33,34") (:form . "18,19,33,34") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.45) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101455@unknown@formal@none@1@S@While genetic analysis has revealed that neur in Drosophila and mib in D. rerio are strictly required for N signaling, knockout studies of mouse Neur1 has indicated that NEUR1 is not strictly required for N signaling [33,34].@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mib") (:form . "mib") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 83) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 117)\n  (:start . 108) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "knockout") (:form . "knockout") (:end . 127)\n  (:start . 119) (:id . 63))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "NN") (:stem . "neur1") (:form . "Neur1") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "NN") (:stem . "neur1") (:form . "NEUR1") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 182) (:start . 179)\n  (:id . 73))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 191)\n  (:start . 183) (:id . 74))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 200)\n  (:start . 192) (:id . 75))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 206) (:start . 205)\n  (:id . 77))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 216)\n  (:start . 207) (:id . 78))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 218) (:start . 217)\n  (:id . 79))\n ((:tag . "CD") (:stem . "33,34") (:form . "33,34") (:end . 223)\n  (:start . 218) (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 224) (:start . 223)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x5.46.1) (:span 155 169)))\n (:hscopes ((:id . :x5.46.1) (:span 155 216)))\n (:identifiers (:sid . :s5.46) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101456@unknown@formal@none@1@S@One possible explanation is functional redundancy with the mouse Neur2 gene.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "explanation") (:form . "explanation") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 38)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "redundancy") (:form . "redundancy") (:end . 49)\n  (:start . 39) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "neur2") (:form . "Neur2") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x5.47.1) (:span 4 12)))\n (:hscopes ((:id . :x5.47.1) (:span 4 75)))\n (:identifiers (:sid . :s5.47) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101457@unknown@formal@none@1@S@Conversely, the function of Drosophila mib (D-mib), the homolog of D. rerio mib gene, is not known.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "mib") (:form . "mib") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 63)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 75) (:start . 70)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mib") (:form . "mib") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 84) (:start . 80)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 92) (:start . 89)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 98) (:start . 93)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x5.48.1) (:span 89 98)))\n (:hscopes ((:id . :x5.48.1) (:span 12 98)))\n (:identifiers (:sid . :s5.48) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101458@unknown@formal@none@1@S@To establish the respective roles of these two distinct E3 ligases in the context of a single model organism, we have studied the function of the Drosophila D-mib gene.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "establish") (:form . "establish") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "respective") (:form . "respective") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "ligas") (:form . "ligases") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 99) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 125)\n  (:start . 118) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 138)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 156)\n  (:start . 146) (:id . 69))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 167) (:start . 163)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s5.49) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101460@unknown@formal@none@1@S@We further show that D-mib is specifically required for Ser endocytosis and signaling during wing development, indicating for the first time, to our knowledge, that endocytosis regulates Ser signaling.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 71)\n  (:start . 60) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 109)\n  (:start . 98) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 135)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 176)\n  (:start . 165) (:id . 70))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 186)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "ser") (:form . "Ser") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 201) (:start . 200)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x5.51.1) (:span 111 121)))\n (:hscopes ((:id . :x5.51.1) (:span 111 200)))\n (:identifiers (:sid . :s5.51) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101461@unknown@formal@none@1@S@Interestingly, the D-mib activity was found necessary for a subset of N signaling events that are distinct from those requiring the activity of the neur gene.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 127)\n  (:start . 118) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 140)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 157) (:start . 153)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s5.52) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101462@unknown@formal@none@1@S@Nevertheless, the ectopic expression of Neur compensates for the loss of D-mib activity in the wing, indicating that Neur and D-mib have overlapping functions.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "compensate") (:form . "compensates") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 148)\n  (:start . 137) (:id . 66))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 158)\n  (:start . 149) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x5.53.1) (:span 101 116)))\n (:hscopes ((:id . :x5.53.1) (:span 101 158)))\n (:identifiers (:sid . :s5.53) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101463@unknown@formal@none@1@S@We conclude that D-mib and Neur are two structurally distinct proteins with similar molecular activities but distinct and complementary functions in Drosophila.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 52)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 104)\n  (:start . 94) (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 117)\n  (:start . 109) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 135) (:start . 122) (:id . 60))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 145)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 159)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.54) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101464@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s5.55) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101465@unknown@formal@none@1@S@Isolation of D-mib Mutations@(((:tag . "NN") (:stem . "isolation") (:form . "Isolation") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NNPS") (:stem . "Mutation") (:form . "Mutations") (:end . 28)\n  (:start . 19) (:id . 45)))@@@1@4@((:identifiers (:sid . :s5.56) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101466@unknown@formal@none@1@S@The closest Drosophila homolog of the vertebrate mib gene is the predicted gene CG5841, D-mib [18].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "close") (:form . "closest") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "mib") (:form . "mib") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cg5841") (:form . "CG5841") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.57) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101467@unknown@formal@none@1@S@The D-mib mutations identified are shown in Figure 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.58) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101468@unknown@formal@none@1@S@A P-element inserted into the 5? untranslated region of the D-mib gene was recently isolated (http://flypush.imgen.bcm.tmc.edu/pscreen/) (Figure 1A).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "p-element") (:form . "P-element") (:end . 11)\n  (:start . 2) (:id . 43))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "untranslated") (:form . "untranslated") (:end . 45)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 65) (:start . 60)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 92)\n  (:start . 84) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "http://flypush.imgen.bcm.tmc.edu/pscreen/")\n  (:form . "http://flypush.imgen.bcm.tmc.edu/pscreen/") (:end . 135)\n  (:start . 94) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 144)\n  (:start . 138) (:id . 62))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 147) (:start . 145)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s5.59) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101470@unknown@formal@none@1@S@Lethality was reverted by precise excision of the P-element, suggesting that insertion of this P-element is a D-mib mutation, referred to as D-mib1.@(((:tag . "NNP") (:stem . "Lethality") (:form . "Lethality") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "revert") (:form . "reverted") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "excision") (:form . "excision") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 59)\n  (:start . 50) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 124)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x5.61.1) (:span 61 71)))\n (:hscopes ((:id . :x5.61.1) (:span 61 147)))\n (:identifiers (:sid . :s5.61) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101471@unknown@formal@none@1@S@A 13.6-kb deletion that removes the entire D-mib coding region was selected by imprecise excision of this P-element.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "13.6-kb") (:form . "13.6-kb") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "remove") (:form . "removes") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 55) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "imprecise") (:form . "imprecise") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . "NN") (:stem . "excision") (:form . "excision") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.62) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101472@unknown@formal@none@1@S@This deletion represents a null allele of D-mib and was named D-mib2.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.63) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101473@unknown@formal@none@1@S@This deletion also deletes the 3? flanking RpS31 gene (Figure 1A).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "delete") (:form . "deletes") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "rps31") (:form . "RpS31") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.64) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101474@unknown@formal@none@1@S@The D-mib1 and D-mib2mutant alleles did not complement the l(3)72CdaJ12 and l(3)72CdaI5 lethal mutations that have been mapped to the same cytological interval as the D-mib gene [35].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "d-mib2mutant") (:form . "D-mib2mutant") (:end . 27)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "complement") (:form . "complement") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "CD") (:stem . "l(3)72CdaJ12") (:form . "l(3)72CdaJ12") (:end . 71)\n  (:start . 59) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "CD") (:stem . "l(3)72CdaI5") (:form . "l(3)72CdaI5") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 104)\n  (:start . 95) (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 114) (:start . 110)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "map") (:form . "mapped") (:end . 126)\n  (:start . 120) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 138) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cytological") (:form . "cytological") (:end . 150)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "interval") (:form . "interval") (:end . 159)\n  (:start . 151) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 162) (:start . 160)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 172)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 177) (:start . 173)\n  (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 179) (:start . 178)\n  (:id . 69))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 181) (:start . 179)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 182) (:start . 181)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x5.65.1) (:span 40 43)))\n (:nscopes ((:id . :x5.65.1) (:span 40 182)))\n (:identifiers (:sid . :s5.65) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101475@unknown@formal@none@1@S@This indicates that these two lethal mutations are D-mib mutant alleles, and they were therefore renamed D-mib3 and D-mib4, respectively.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 81) (:start . 77)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "VBN") (:stem . "rename") (:form . "renamed") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "d-mib4") (:form . "D-mib4") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 136)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x5.66.1) (:span 5 19)))\n (:hscopes ((:id . :x5.66.1) (:span 5 71)))\n (:identifiers (:sid . :s5.66) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101476@unknown@formal@none@1@S@The D-mib1 and D-mib3 mutations behave as genetic null alleles (see Materials and Methods).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "VBP") (:stem . "behave") (:form . "behave") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.67) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101477@unknown@formal@none@1@S@In contrast, D-mib4 is a partial loss-of-function allele because flies trans-heterozygous for D-mib4 and any other D-mib null alleles are viable.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib4") (:form . "D-mib4") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 32)\n  (:start . 25) (:id . 48))\n ((:tag . "JJ") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 49) (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 56)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "trans-heterozygous") (:form . "trans-heterozygous")\n  (:end . 89) (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 93) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "d-mib4") (:form . "D-mib4") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 108) (:start . 105)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 114)\n  (:start . 109) (:id . 58))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 120)\n  (:start . 115) (:id . 59))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 133)\n  (:start . 126) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.68) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101478@unknown@formal@none@1@S@These four mutations identify the CG5841 gene as D-mib by the following evidence.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "identify") (:form . "identify") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cg5841") (:form . "CG5841") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.69) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101480@unknown@formal@none@1@S@Second, genomic sequencing of the D-mib3 allele revealed the presence of a stop codon at position 258 (Figure 1B).@(((:tag . "JJ") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 69)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "CD") (:stem . "258") (:form . "258") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.71) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101481@unknown@formal@none@1@S@This allele is therefore predicted to produce a truncated protein devoid of the catalytic RING domain, consistent with D-mib3 being a null allele.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "JJ") (:stem . "devoid") (:form . "devoid") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 113)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "D-mib3") (:form . "D-mib3") (:end . 125)\n  (:start . 119) (:id . 61))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 131) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 138) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 145)\n  (:start . 139) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x5.72.1) (:span 25 34)))\n (:hscopes ((:id . :x5.72.1) (:span 0 145)))\n (:identifiers (:sid . :s5.72) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101482@unknown@formal@none@1@S@Genomic sequencing of the D-mib4 allele showed that this mutation is associated with a valine-to-methionine substitution at a conserved position in the second Mib repeat (Figure 1B).@(((:tag . "JJ") (:stem . "genomic") (:form . "Genomic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "d-mib4") (:form . "D-mib4") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 46) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "valine-to-methionine")\n  (:form . "valine-to-methionine") (:end . 107) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 120)\n  (:start . 108) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 123) (:start . 121)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 135)\n  (:start . 126) (:id . 60))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 158)\n  (:start . 152) (:id . 64))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 162) (:start . 159)\n  (:id . 65))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 169)\n  (:start . 163) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 180) (:start . 178)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.73) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101483@unknown@formal@none@1@S@Third, Western blot analysis showed that the D-mib protein was not detectable in imaginal disc and brain complex extracts prepared from homozygous D-mib1 and D-mib1/D-mib2 larvae (Figure 1C and C?).@(((:tag . "JJ") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 35) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 89)\n  (:start . 81) (:id . 56))\n ((:tag . "NN") (:stem . "disc") (:form . "disc") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 130)\n  (:start . 122) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 153)\n  (:start . 147) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 157) (:start . 154)\n  (:id . 66))\n ((:tag . "NN") (:stem . "d-mib1/d-mib2") (:form . "D-mib1/D-mib2")\n  (:end . 171) (:start . 158) (:id . 67))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 178)\n  (:start . 172) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 186)\n  (:start . 180) (:id . 70))\n ((:tag . "NN") (:stem . "1c") (:form . "1C") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 195) (:start . 194)\n  (:id . 73))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x5.74.1) (:span 63 66)))\n (:nscopes ((:id . :x5.74.1) (:span 63 178)))\n (:identifiers (:sid . :s5.74) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101484@unknown@formal@none@1@S@Fourth, the leaky, GAL4-independent expression of a UAS-D-mib transgene fully rescued the lethality of D-mib1/D-mib2 flies (data not shown; see also Figure 1H).@(((:tag . "NNP") (:stem . "Fourth") (:form . "Fourth") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "leaky") (:form . "leaky") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "gal4-independent") (:form . "GAL4-independent")\n  (:end . 35) (:start . 19) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "uas-d-mib") (:form . "UAS-D-mib") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "NN") (:stem . "d-mib1/d-mib2") (:form . "D-mib1/D-mib2")\n  (:end . 116) (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 122) (:start . 117)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 128)\n  (:start . 124) (:id . 61))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 138)\n  (:start . 133) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 139) (:start . 138)\n  (:id . 64))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 155)\n  (:start . 149) (:id . 67))\n ((:tag . "NN") (:stem . "1h") (:form . "1H") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x5.75.1) (:span 129 132)))\n (:nscopes ((:id . :x5.75.1) (:span 123 138)))\n (:identifiers (:sid . :s5.75) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101485@unknown@formal@none@1@S@Thus, our analysis identified both complete and partial D-mib loss-of-function alleles.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 78) (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 86)\n  (:start . 79) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.76) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101486@unknown@formal@none@1@S@Molecular and Genetic Characterization of D-mib Mutations@(((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "genetic") (:form . "Genetic") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "characterization") (:form . "Characterization")\n  (:end . 38) (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 47) (:start . 42)\n  (:id . 47))\n ((:tag . "NNPS") (:stem . "Mutation") (:form . "Mutations") (:end . 57)\n  (:start . 48) (:id . 48)))@@@1@7@((:identifiers (:sid . :s5.77) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101487@unknown@formal@none@1@S@(A) Molecular map of the D-mib locus showing the position of the P-element inserted into the 5? untranslated region (allele D-mib1) and the 13.6 kb deletion that removes the D-mib and the RpS31 genes (allele D-mib2).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "molecular") (:form . "Molecular") (:end . 13)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "map") (:form . "map") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 30) (:start . 25)\n  (:id . 49))\n ((:tag . "NN") (:stem . "locus") (:form . "locus") (:end . 36) (:start . 31)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 44)\n  (:start . 37) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 57)\n  (:start . 49) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "p-element") (:form . "P-element") (:end . 74)\n  (:start . 65) (:id . 56))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 95) (:start . 94)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "untranslated") (:form . "untranslated") (:end . 108)\n  (:start . 96) (:id . 62))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 123)\n  (:start . 117) (:id . 65))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 130)\n  (:start . 124) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 69))\n ((:tag . "CD") (:stem . "13.6") (:form . "13.6") (:end . 144) (:start . 140)\n  (:id . 70))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 147) (:start . 145)\n  (:id . 71))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 156)\n  (:start . 148) (:id . 72))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 161) (:start . 157)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "remove") (:form . "removes") (:end . 169)\n  (:start . 162) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 173) (:start . 170)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 179)\n  (:start . 174) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 78))\n ((:tag . "NN") (:stem . "rps31") (:form . "RpS31") (:end . 193)\n  (:start . 188) (:id . 79))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 199)\n  (:start . 194) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 81))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 207)\n  (:start . 201) (:id . 82))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 214)\n  (:start . 208) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s5.78) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101488@unknown@formal@none@1@S@Transcribed regions are indicated with arrows, and exons are indicated with boxes.@(((:tag . "VBN") (:stem . "transcribe") (:form . "Transcribed") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 19)\n  (:start . 12) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "arrow") (:form . "arrows") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "box") (:form . "boxes") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.79) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101490@unknown@formal@none@1@S@(B) Domain composition of D-mib and D. rerio Mib.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "Domain") (:form . "Domain") (:end . 10)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "composition") (:form . "composition") (:end . 22)\n  (:start . 11) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 31) (:start . 26)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "rerio") (:form . "rerio") (:end . 44) (:start . 39)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s5.81) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101491@unknown@formal@none@1@S@Both proteins show identical domain organization.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "organization") (:form . "organization") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s5.82) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101492@unknown@formal@none@1@S@D-mib has an N-terminal ZZ zinc finger flanked on either side by a Mib/HERC2 (M-H) domain, followed by two Mib repeats, six ankyrin repeats, two atypical RING domains, and a C-terminal protypical RING that has been associated with catalytic E3 ubiquitin ligase activity.@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "ZZ") (:form . "ZZ") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "VBN") (:stem . "flank") (:form . "flanked") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Mib/HERC2") (:form . "Mib/HERC2") (:end . 76)\n  (:start . 67) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "M-H") (:form . "M-H") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 89)\n  (:start . 83) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 99)\n  (:start . 91) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 102) (:start . 100)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 118)\n  (:start . 111) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 66))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 123) (:start . 120)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ankyrin") (:form . "ankyrin") (:end . 131)\n  (:start . 124) (:id . 68))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 139)\n  (:start . 132) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 144) (:start . 141)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 153)\n  (:start . 145) (:id . 72))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 158) (:start . 154)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 166)\n  (:start . 159) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 171) (:start . 168)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 173) (:start . 172)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 184)\n  (:start . 174) (:id . 78))\n ((:tag . "JJ") (:stem . "protypical") (:form . "protypical") (:end . 195)\n  (:start . 185) (:id . 79))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 200) (:start . 196)\n  (:id . 80))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 205) (:start . 201)\n  (:id . 81))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 209) (:start . 206)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 214) (:start . 210)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 225)\n  (:start . 215) (:id . 84))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 230) (:start . 226)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 240)\n  (:start . 231) (:id . 86))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 243) (:start . 241)\n  (:id . 87))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 253)\n  (:start . 244) (:id . 88))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 260)\n  (:start . 254) (:id . 89))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 269)\n  (:start . 261) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 270) (:start . 269)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s5.83) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101493@unknown@formal@none@1@S@The D-mib3 mutant allele is predicted to produce a truncated protein devoid of E3 ubiquitin ligase activity whereas the D-mib4 protein carries a mutation at a conserved position in the second Mib repeat.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "truncate") (:form . "truncated") (:end . 60)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "devoid") (:form . "devoid") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 98)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "d-mib4") (:form . "D-mib4") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 134)\n  (:start . 127) (:id . 62))\n ((:tag . "VBZ") (:stem . "carry") (:form . "carries") (:end . 142)\n  (:start . 135) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 153)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 168)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 177)\n  (:start . 169) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 191)\n  (:start . 185) (:id . 72))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 195) (:start . 192)\n  (:id . 73))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 202)\n  (:start . 196) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x5.84.1) (:span 28 37)))\n (:hscopes ((:id . :x5.84.1) (:span 0 107)))\n (:identifiers (:sid . :s5.84) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101494@unknown@formal@none@1@S@(C and C?) Western blot analysis of D-mib (C).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 18)\n  (:start . 11) (:id . 48))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 23) (:start . 19)\n  (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 32)\n  (:start . 24) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 41) (:start . 36)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 44) (:start . 43)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.85) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101495@unknown@formal@none@1@S@The endogenous D-mib protein (predicted size: 130 kDa) was detected in S2 cells (lane 2) and in imaginal discs from wild-type larvae (lane 3) but was not detectable in homozygous D-mib1 (lane 4) and D-mib1/D-mib3 (lane 5) third instar larvae.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "CD") (:stem . "130") (:form . "130") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "kda") (:form . "kDa") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lane") (:form . "lane") (:end . 85) (:start . 81)\n  (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 104)\n  (:start . 96) (:id . 64))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 110)\n  (:start . 105) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 115) (:start . 111)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 125)\n  (:start . 116) (:id . 67))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 132)\n  (:start . 126) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lane") (:form . "lane") (:end . 138) (:start . 134)\n  (:id . 70))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 140) (:start . 139)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 145) (:start . 142)\n  (:id . 73))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 149) (:start . 146)\n  (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 153) (:start . 150)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 164)\n  (:start . 154) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 178)\n  (:start . 168) (:id . 78))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 185)\n  (:start . 179) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 80))\n ((:tag . "NN") (:stem . "lane") (:form . "lane") (:end . 191) (:start . 187)\n  (:id . 81))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 193) (:start . 192)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 198) (:start . 195)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "D-mib1/D-mib3") (:form . "D-mib1/D-mib3")\n  (:end . 212) (:start . 199) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 214) (:start . 213)\n  (:id . 86))\n ((:tag . "NN") (:stem . "lane") (:form . "lane") (:end . 218) (:start . 214)\n  (:id . 87))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 220) (:start . 219)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 221) (:start . 220)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 227)\n  (:start . 222) (:id . 90))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 234)\n  (:start . 228) (:id . 91))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 241)\n  (:start . 235) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 93)))@@@1@52@((:ncues ((:id . :x5.86.1) (:span 150 153)))\n (:nscopes ((:id . :x5.86.1) (:span 150 241)))\n (:identifiers (:sid . :s5.86) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101496@unknown@formal@none@1@S@The D-mib protein produced in transfected S2 cells from the cDNA used in this study (lane 1) runs exactly as endogenous D-mib (lane 2).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cdna") (:form . "cDNA") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lane") (:form . "lane") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "run") (:form . "runs") (:end . 97) (:start . 93)\n  (:id . 61))\n ((:tag . "RB") (:stem . "exactly") (:form . "exactly") (:end . 105)\n  (:start . 98) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 119)\n  (:start . 109) (:id . 64))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 125)\n  (:start . 120) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . "NN") (:stem . "lane") (:form . "lane") (:end . 131) (:start . 127)\n  (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 133) (:start . 132)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 134) (:start . 133)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s5.87) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101497@unknown@formal@none@1@S@Panel C? shows a Red Ponceau staining of the gel with the same protein samples as in panel C.@(((:tag . "NNP") (:stem . "Panel") (:form . "Panel") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Red") (:form . "Red") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ponceau") (:form . "Ponceau") (:end . 28)\n  (:start . 21) (:id . 48))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 37)\n  (:start . 29) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gel") (:form . "gel") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 62) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 70)\n  (:start . 63) (:id . 56))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "panel") (:form . "panel") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 92) (:start . 91)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s5.88) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101498@unknown@formal@none@1@S@(D–H) Wings from wild-type (D), D-mib1 (E), SerRX82/Serrev6.1 (F), D-mib2/D-mib4 (G), and UAS-D-mib2/+; D-mib1/D-mib2 flies (H).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D–H") (:form . "D–H") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "NNS") (:stem . "wing") (:form . "Wings") (:end . 11) (:start . 6)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 26)\n  (:start . 17) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D-mib1") (:form . "D-mib1") (:end . 38)\n  (:start . 32) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 41) (:start . 40)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "SerRX82/Serrev6.1") (:form . "SerRX82/Serrev6.1")\n  (:end . 61) (:start . 44) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "F") (:form . "F") (:end . 64) (:start . 63)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D-mib2/D-mib4") (:form . "D-mib2/D-mib4")\n  (:end . 80) (:start . 67) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 83) (:start . 82)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "uas-d-mib2/+") (:form . "UAS-D-mib2/+") (:end . 102)\n  (:start . 90) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 103) (:start . 102)\n  (:id . 69))\n ((:tag . "NN") (:stem . "d-mib1/d-mib2") (:form . "D-mib1/D-mib2")\n  (:end . 117) (:start . 104) (:id . 70))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 123) (:start . 118)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 126) (:start . 125)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s5.89) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101500@unknown@formal@none@1@S@The D-mib mutant phenotype could be almost fully rescued by a leaky UAS-D-mib transgene (H).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "leaky") (:form . "leaky") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "UAS-D-mib") (:form . "UAS-D-mib") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "NN") (:stem . "transgene") (:form . "transgene") (:end . 87)\n  (:start . 78) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.91) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101501@unknown@formal@none@1@S@(D?) and (G?) show high magnification views of (D) and (G), respectively, to show that D-mib2/D-mib4 mutant flies (G?) exhibited ectopic sensilla (arrowheads) along vein L3.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "d") (:form . "D") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 4) (:start . 3) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 10) (:start . 9)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 11) (:start . 10)\n  (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 12) (:start . 11)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 13) (:start . 12)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 23) (:start . 19)\n  (:id . 52))\n ((:tag . "NN") (:stem . "magnification") (:form . "magnification")\n  (:end . 37) (:start . 24) (:id . 53))\n ((:tag . "NNS") (:stem . "view") (:form . "views") (:end . 43) (:start . 38)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 49) (:start . 48)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 57) (:start . 56)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 58) (:start . 57)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 63))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 72)\n  (:start . 60) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 66))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 81) (:start . 77)\n  (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 86) (:start . 82)\n  (:id . 68))\n ((:tag . "NN") (:stem . "d-mib2/d-mib4") (:form . "D-mib2/D-mib4")\n  (:end . 100) (:start . 87) (:id . 69))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 107)\n  (:start . 101) (:id . 70))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 113) (:start . 108)\n  (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 116) (:start . 115)\n  (:id . 73))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 117) (:start . 116)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 75))\n ((:tag . "VBD") (:stem . "exhibit") (:form . "exhibited") (:end . 128)\n  (:start . 119) (:id . 76))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 136)\n  (:start . 129) (:id . 77))\n ((:tag . "NN") (:stem . "sensilla") (:form . "sensilla") (:end . 145)\n  (:start . 137) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "arrowhead") (:form . "arrowheads") (:end . 157)\n  (:start . 147) (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 81))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 164)\n  (:start . 159) (:id . 82))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 169) (:start . 165)\n  (:id . 83))\n ((:tag . "NN") (:stem . "l3") (:form . "L3") (:end . 172) (:start . 170)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s5.92) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101502@unknown@formal@none@1@S@(I–N) Nota (I–K) and legs (L–N) from wild-type (I and L), D-mib1 (J and M), and SerRX82/Serrev6.1 (K and N) flies.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "I–N") (:form . "I–N") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "NNP") (:stem . "Nota") (:form . "Nota") (:end . 10) (:start . 6)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 12) (:start . 11)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "I–K") (:form . "I–K") (:end . 15) (:start . 12)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 16) (:start . 15)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "leg") (:form . "legs") (:end . 25) (:start . 21)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "L–N") (:form . "L–N") (:end . 30) (:start . 27)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 46)\n  (:start . 37) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 56))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 49) (:start . 48)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "L") (:form . "L") (:end . 55) (:start . 54)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D-mib1") (:form . "D-mib1") (:end . 64)\n  (:start . 58) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 67) (:start . 66)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 73) (:start . 72)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "SerRX82/Serrev6.1") (:form . "SerRX82/Serrev6.1")\n  (:end . 97) (:start . 80) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 100) (:start . 99)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 106) (:start . 105)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 113) (:start . 108)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s5.93) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101503@unknown@formal@none@1@S@D-mib mutant flies showed a weak neurogenic phenotype (J) that was not observed in Ser mutant flies (K).@(((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 25) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "neurogenic") (:form . "neurogenic") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 93)\n  (:start . 87) (:id . 59))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "K") (:form . "K") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x5.94.1) (:span 67 70)))\n (:nscopes ((:id . :x5.94.1) (:span 58 103)))\n (:identifiers (:sid . :s5.94) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101504@unknown@formal@none@1@S@Ectopic sensory organs in D-mib mutant flies developed from ectopic sensory organ precursor cells (not shown).@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "develop") (:form . "developed") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 91)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x5.95.1) (:span 98 102)))\n (:nscopes ((:id . :x5.95.1) (:span 60 109)))\n (:identifiers (:sid . :s5.95) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101505@unknown@formal@none@1@S@D-mib (M) and Ser (N) mutant legs also showed distinct growth and/or elongation defects.@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "M") (:form . "M") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 9) (:start . 8) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 17) (:start . 14)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 19) (:start . 18)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 20) (:start . 19)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 28)\n  (:start . 22) (:id . 51))\n ((:tag . "NNS") (:stem . "leg") (:form . "legs") (:end . 33) (:start . 29)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 38) (:start . 34)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 45) (:start . 39)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 54)\n  (:start . 46) (:id . 55))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 61)\n  (:start . 55) (:id . 56))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 68)\n  (:start . 62) (:id . 57))\n ((:tag . "NN") (:stem . "elongation") (:form . "elongation") (:end . 79)\n  (:start . 69) (:id . 58))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 87)\n  (:start . 80) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.96) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101506@unknown@formal@none@1@S@Arrows in (J) show ectopic macrochaetes.@(((:tag . "NNS") (:stem . "arrow") (:form . "Arrows") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 13) (:start . 12)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 18) (:start . 14)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 26)\n  (:start . 19) (:id . 48))\n ((:tag . "NNS") (:stem . "macrochaete") (:form . "macrochaetes") (:end . 39)\n  (:start . 27) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 40) (:start . 39)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s5.97) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101507@unknown@formal@none@1@S@Arrows in (L–N) indicate the joints.@(((:tag . "NNS") (:stem . "arrow") (:form . "Arrows") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "L–N") (:form . "L–N") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 24)\n  (:start . 16) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "joint") (:form . "joints") (:end . 35)\n  (:start . 29) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 36) (:start . 35)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s5.98) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101508@unknown@formal@none@1@S@Ti, tibia; t1 to t5, tarsal segments 1 to 5.@(((:tag . "NNP") (:stem . "Ti") (:form . "Ti") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "tibia") (:form . "tibia") (:end . 9) (:start . 4)\n  (:id . 44))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t1") (:form . "t1") (:end . 13) (:start . 11)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 16) (:start . 14)\n  (:id . 47))\n ((:tag . "NN") (:stem . "t5") (:form . "t5") (:end . 19) (:start . 17)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 49))\n ((:tag . "NN") (:stem . "tarsal") (:form . "tarsal") (:end . 27)\n  (:start . 21) (:id . 50))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 36)\n  (:start . 28) (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 38) (:start . 37)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 53))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 43) (:start . 42)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 44) (:start . 43)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.99) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101510@unknown@formal@none@1@S@Complete loss of zygotic D-mib activity in homozygous D-mib1 and trans-heterozygous D-mib2/D-mib3, D-mib1/D-mib3 and D-mib1/D-mib2 individuals led to late pupal lethality.@(((:tag . "JJ") (:stem . "complete") (:form . "Complete") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "zygotic") (:form . "zygotic") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 60)\n  (:start . 54) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "trans-heterozygous") (:form . "trans-heterozygous")\n  (:end . 83) (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 97) (:start . 84) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "d-mib1/d-mib3") (:form . "D-mib1/D-mib3")\n  (:end . 112) (:start . 99) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 56))\n ((:tag . "NN") (:stem . "d-mib1/d-mib2") (:form . "D-mib1/D-mib2")\n  (:end . 130) (:start . 117) (:id . 57))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 142)\n  (:start . 131) (:id . 58))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 146) (:start . 143)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 154) (:start . 150)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 160)\n  (:start . 155) (:id . 62))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 170)\n  (:start . 161) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.101) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101511@unknown@formal@none@1@S@Mutant pupae died as pharate adults showing ectopic macrochaetes, increased microchaete density on the dorsal thorax (Figure 1I and 1J), short legs lacking tarsal segmentation (Figure 1L and 1M), and nearly complete loss of eye and wing tissues (Figure 1D and 1E).@(((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "die") (:form . "died") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "pharate") (:form . "pharate") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "macrochaete") (:form . "macrochaetes") (:end . 64)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "microchaete") (:form . "microchaete") (:end . 87)\n  (:start . 76) (:id . 53))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 95)\n  (:start . 88) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 98) (:start . 96)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 109)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "thorax") (:form . "thorax") (:end . 116)\n  (:start . 110) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . 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5101512@unknown@formal@none@1@S@Tissue losses were associated with a dramatic reduction in size of the eye field and of the wing pouch in mutant discs of third instar larvae (Figure 2A–2E).@(((:tag . "NN") (:stem . "tissue") (:form . "Tissue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "loss") (:form . "losses") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 55)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "eye") (:form . "eye") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 127)\n  (:start . 122) (:id . 65))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 134)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "larvae") (:form . "larvae") (:end . 141)\n  (:start . 135) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 149)\n  (:start . 143) (:id . 69))\n ((:tag . "NNP") (:stem . "2A–2E") (:form . "2A–2E") (:end . 155)\n  (:start . 150) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s5.103) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101513@unknown@formal@none@1@S@Hypomorphic D-mib2/D-mib4 mutant flies only showed ectopic sensory organs, rough eyes, small wings, and thickened veins (Figure 1D, 1D?, 1G, and 1G?; data not shown).@(((:tag . "JJ") (:stem . "hypomorphic") (:form . "Hypomorphic") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D-mib2/D-mib4") (:form . "D-mib2/D-mib4")\n  (:end . 25) (:start . 12) (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 32)\n  (:start . 26) (:id . 44))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 38) (:start . 33)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 43) (:start . 39)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 50) (:start . 44)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "rough") (:form . "rough") (:end . 80) (:start . 75)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "eye") (:form . "eyes") (:end . 85) (:start . 81)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "wing") (:form . "wings") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "thicken") (:form . "thickened") (:end . 113)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "vein") (:form . "veins") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "1d") (:form . "1D") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "1d") (:form . "1D") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "1g") (:form . "1G") (:end . 139) (:start . 137)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 70))\n ((:tag . "NN") (:stem . "1g") (:form . "1G") (:end . 147) (:start . 145)\n  (:id . 71))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 148) (:start . 147)\n  (:id . 72))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 149) (:start . 148)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 154)\n  (:start . 150) (:id . 74))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 158) (:start . 155)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 164)\n  (:start . 159) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 78)))@@@1@37@((:ncues ((:id . :x5.104.1) (:span 155 158)))\n (:nscopes ((:id . :x5.104.1) (:span 150 165)))\n (:identifiers (:sid . :s5.104) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101514@unknown@formal@none@1@S@All these phenotypes may result from reduced N signaling.@(((:tag . "PDT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 46) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 57) (:start . 56)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x5.105.1) (:span 21 24)))\n (:hscopes ((:id . :x5.105.1) (:span 21 56)))\n (:identifiers (:sid . :s5.105) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101515@unknown@formal@none@1@S@More specifically, the bristle and leg phenotypes are likely to result from reduced signaling by Dl (and not by Ser).@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bristle") (:form . "bristle") (:end . 30)\n  (:start . 23) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "leg") (:form . "leg") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x5.106.2) (:span 54 60)))\n (:ncues ((:id . :x5.106.1) (:span 105 108)))\n (:hscopes ((:id . :x5.106.2) (:span 19 116)))\n (:nscopes ((:id . :x5.106.1) (:span 105 116)))\n (:identifiers (:sid . :s5.106) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101516@unknown@formal@none@1@S@Indeed, a reduction in Dl-mediated lateral inhibition can result in ectopic sensory organs and increased bristle density on the body surface.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 19)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dl-mediated") (:form . "Dl-mediated") (:end . 34)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "lateral") (:form . "lateral") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 90)\n  (:start . 84) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "JJ") (:stem . "bristle") (:form . "bristle") (:end . 112)\n  (:start . 105) (:id . 58))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 120)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 132) (:start . 128)\n  (:id . 62))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 140)\n  (:start . 133) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.107) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101517@unknown@formal@none@1@S@In contrast, a complete loss of Ser signaling had no effect on bristle density (Figure 1K).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "bristle") (:form . "bristle") (:end . 70)\n  (:start . 63) (:id . 55))\n ((:tag . "NN") (:stem . "density") (:form . "density") (:end . 78)\n  (:start . 71) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "1k") (:form . "1K") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x5.108.1) (:span 50 52)))\n (:nscopes ((:id . :x5.108.1) (:span 50 78)))\n (:identifiers (:sid . :s5.108) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101518@unknown@formal@none@1@S@Likewise, loss of Dl signaling has been shown to result in short unsegmented legs, similar to the ones seen in the absence of D-mib activity (Figure 1M), whereas a complete loss of Ser activity led to the formation of elongated unsegmented legs (Figure 1N) [36,37,38].@(((:tag . "RB") (:stem . "likewise") (:form . "Likewise") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . 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"1N") (:end . 255) (:start . 253)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 256) (:start . 255)\n  (:id . 92))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 258) (:start . 257)\n  (:id . 93))\n ((:tag . "CD") (:stem . "36,37,38") (:form . "36,37,38") (:end . 266)\n  (:start . 258) (:id . 94))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 267) (:start . 266)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s5.109) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101520@unknown@formal@none@1@S@Together, these observations suggest that D-mib regulates Dl signaling in several developmental contexts.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 28)\n  (:start . 16) (:id . 45))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 95) (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "context") (:form . "contexts") (:end . 104)\n  (:start . 96) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x5.111.1) (:span 29 36)))\n (:hscopes ((:id . :x5.111.1) (:span 29 104)))\n (:identifiers (:sid . :s5.111) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101521@unknown@formal@none@1@S@Consistent with this conclusion, we have shown that D-mib binds Dl and promotes Dl signaling and that overexpression of D-mib down-regulates the accumulation of Dl at the cell surface (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data).@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . 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5101522@unknown@formal@none@1@S@The D-mib and neur Genes Have Distinct Functions during Wing Development@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Genes") (:form . "Genes") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Have") (:form . "Have") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Distinct") (:form . "Distinct") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NNPS") (:stem . "Function") (:form . "Functions") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNP") (:stem . "Wing") (:form . "Wing") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 72)\n  (:start . 61) (:id . 52)))@@@1@11@((:identifiers (:sid . :s5.113) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101523@unknown@formal@none@1@S@(A–E) Wing imaginal discs (B–E) from wild-type (B and D), D-mib1 (C), and D-mib1/D-mib2 (E) third instar larvae stained for Cut (B and C) and wg-lacZ (D and E).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A–E") (:form . "A–E") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "VBG") (:stem . "wing") (:form . "Wing") (:end . 10) (:start . 6)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 19)\n  (:start . 11) (:id . 46))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B–E") (:form . "B–E") (:end . 30) (:start . 27)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 36) (:start . 32)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 46)\n  (:start . 37) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 55) (:start . 54)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D-mib1") (:form . "D-mib1") (:end . 64)\n  (:start . 58) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 67) (:start . 66)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "D-mib1/D-mib2") (:form . "D-mib1/D-mib2")\n  (:end . 87) (:start . 74) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 90) (:start . 89)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 97) (:start . 92)\n  (:id . 69))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 104)\n  (:start . 98) (:id . 70))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 111)\n  (:start . 105) (:id . 71))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 119)\n  (:start . 112) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 123) (:start . 120)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 127) (:start . 124)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 130) (:start . 129)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 136) (:start . 135)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "wg-lacZ") (:form . "wg-lacZ") (:end . 149)\n  (:start . 142) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 152) (:start . 151)\n  (:id . 83))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 158) (:start . 157)\n  (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 87)))@@@1@46@((:identifiers (:sid . :s5.114) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101524@unknown@formal@none@1@S@D-mib mutant discs showed a dramatically reduced size of the wing pouch (see diagram in [A] showing the different regions of the wing imaginal disc; V, ventral; D, dorsal), as well as a complete loss of Cut and wg-lacZ (red arrows in [B–E]) expression at the wing margin.@(((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 25) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . 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5101525@unknown@formal@none@1@S@Expression of wg-lacZ in the hinge region (arrowheads in [D] and [E]) and the accumulation of Cut in sensory cells (small arrows in [B] and [C]) and muscle precursor cells (large arrowheads in [B] and [C]) appeared to be largely unaffected).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "wg-lacz") (:form . "wg-lacZ") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hinge") (:form . "hinge") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . 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5101526@unknown@formal@none@1@S@(F and F?) Expression of Cut (red) at the wing margin was not affected by the complete loss of neur activity in neur1F65 mutant clones (indicated by the loss of the nuclear green fluorescent protein [GFP] marker, in green).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "F") (:form . "F") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 21)\n  (:start . 11) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Cut") (:form . 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"clones") (:end . 134)\n  (:start . 128) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 145)\n  (:start . 136) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 148) (:start . 146)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 75))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 157) (:start . 153)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 172)\n  (:start . 165) (:id . 79))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 178)\n  (:start . 173) (:id . 80))\n ((:tag . "JJ") (:stem . "fluorescent") (:form . "fluorescent") (:end . 190)\n  (:start . 179) (:id . 81))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 198)\n  (:start . 191) (:id . 82))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 200) (:start . 199)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 203) (:start . 200)\n  (:id . 84))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 204) (:start . 203)\n  (:id . 85))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 211)\n  (:start . 205) (:id . 86))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 221)\n  (:start . 216) (:id . 89))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 91)))@@@1@50@((:ncues ((:id . :x5.117.1) (:span 58 61)))\n (:nscopes ((:id . :x5.117.1) (:span 0 134)))\n (:identifiers (:sid . :s5.117) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101527@unknown@formal@none@1@S@Bar is 50 ?m in (B–E) and 20 ?m in (F and F?).@(((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "B–E") (:form . "B–E") (:end . 20) (:start . 17)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 21) (:start . 20)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 50))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 28) (:start . 26)\n  (:id . 51))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 31) (:start . 29)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 54))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 37) (:start . 36)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 56))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 43) (:start . 42)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 44) (:start . 43)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.118) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101528@unknown@formal@none@1@S@D-mib and neur Have Distinct Functions@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "Have") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "NNPS") (:stem . "Function") (:form . "Functions") (:end . 38)\n  (:start . 29) (:id . 47)))@@@1@6@((:identifiers (:sid . :s5.119) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101530@unknown@formal@none@1@S@Growth of the wing pouch depends on the activity of an organizing center located at the dorsal-ventral (D-V) boundary [40,41].@(((:tag . "NN") (:stem . "growth") (:form . "Growth") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "depend") (:form . "depends") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "organize") (:form . "organizing") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dorsal-ventral") (:form . "dorsal-ventral")\n  (:end . 102) (:start . 88) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "boundary") (:form . "boundary") (:end . 117)\n  (:start . 109) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "CD") (:stem . "40,41") (:form . "40,41") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s5.121) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101531@unknown@formal@none@1@S@This boundary is established in first instar larvae and is defined by the apterous expression boundary.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "apterous") (:form . "apterous") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.122) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101532@unknown@formal@none@1@S@Apterous activates the expression of the Ser and fringe genes in dorsal cells.@(((:tag . "JJ") (:stem . "apterous") (:form . "Apterous") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fringe") (:form . "fringe") (:end . 55)\n  (:start . 49) (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.123) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101533@unknown@formal@none@1@S@High levels of Ser in dorsal cells activate N in trans in ventral cells and suppress N activation in cis in dorsal cells, whereas Fringe modifies N in dorsal cells such that dorsal cells located at the D-V boundary respond to Dl.@(((:tag . "JJ") (:stem . "high") (:form . "High") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "activate") (:form . "activate") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tran") (:form . "trans") (:end . 54) (:start . 49)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "suppress") (:form . "suppress") (:end . 84)\n  (:start . 76) (:id . 57))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cis") (:form . "cis") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 114)\n  (:start . 108) (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 129)\n  (:start . 122) (:id . 66))\n ((:tag . "NNP") (:stem . "Fringe") (:form . "Fringe") (:end . 136)\n  (:start . 130) (:id . 67))\n ((:tag . "VBZ") (:stem . "modify") (:form . "modifies") (:end . 145)\n  (:start . 137) (:id . 68))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 147) (:start . 146)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 157)\n  (:start . 151) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 163)\n  (:start . 158) (:id . 72))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 168) (:start . 164)\n  (:id . 73))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 173) (:start . 169)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 180)\n  (:start . 174) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 186)\n  (:start . 181) (:id . 76))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 194)\n  (:start . 187) (:id . 77))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 197) (:start . 195)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 205) (:start . 202)\n  (:id . 80))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 214)\n  (:start . 206) (:id . 81))\n ((:tag . "VBP") (:stem . "respond") (:form . "respond") (:end . 222)\n  (:start . 215) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 225) (:start . 223)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 228) (:start . 226)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s5.124) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101534@unknown@formal@none@1@S@Thus, composite signaling by Ser and Dl leads to symmetric N activation in margin cells located along the D-V boundary [8,9,42,43].@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "composite") (:form . "composite") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "symmetric") (:form . "symmetric") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "located") (:form . "located") (:end . 95)\n  (:start . 88) (:id . 58))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 109) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 118)\n  (:start . 110) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "CD") (:stem . "8,9,42,43") (:form . "8,9,42,43") (:end . 129)\n  (:start . 120) (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 130) (:start . 129)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s5.125) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101535@unknown@formal@none@1@S@N then regulates the expression of the vestigial and wingless (wg) genes that cooperate to promote growth of the wing pouch.@(((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "vestigial") (:form . "vestigial") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "wingless") (:form . "wingless") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "wg") (:form . "wg") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "cooperate") (:form . "cooperate") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 98)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 105)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 123)\n  (:start . 118) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s5.126) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101536@unknown@formal@none@1@S@N also regulates expression of the cut gene in margin cells [44].@(((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cut") (:form . "cut") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.127) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101537@unknown@formal@none@1@S@Thus, loss of N signaling results in a reduction in size of the wing pouch accompanied by the loss of cut and wg expression along the D-V boundary.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 15) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 25)\n  (:start . 16) (:id . 47))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 33)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 48)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 56) (:start . 52)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 68) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 74) (:start . 69)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 86)\n  (:start . 75) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cut") (:form . "cut") (:end . 105) (:start . 102)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 64))\n ((:tag . "NN") (:stem . "wg") (:form . "wg") (:end . 112) (:start . 110)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 123)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 129)\n  (:start . 124) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 137) (:start . 134)\n  (:id . 69))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 146)\n  (:start . 138) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.128) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101538@unknown@formal@none@1@S@A complete loss of Cut and Wg accumulation and wg-lacZ expression was observed in the central region of third instar D-mib mutant wing discs (data not shown).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Wg") (:form . "Wg") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 42)\n  (:start . 30) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "wg-lacz") (:form . "wg-lacZ") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 129)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 146)\n  (:start . 142) (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x5.129.1) (:span 147 150)))\n (:nscopes ((:id . :x5.129.1) (:span 141 157)))\n (:identifiers (:sid . :s5.129) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101540@unknown@formal@none@1@S@We conclude that the activity of the D-mib gene is required for the specification of the wing margin and, hence, growth of the wing pouch.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 81) (:start . 68) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 119)\n  (:start . 113) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 131) (:start . 127)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s5.131) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101541@unknown@formal@none@1@S@Interestingly, wing margin formation and expression of Cut are not affected by the complete loss of neur activity (Figure 2F and 2F?) [45].@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "NN") (:stem . "2f") (:form . "2F") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NN") (:stem . "2f") (:form . "2F") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 135) (:start . 134)\n  (:id . 68))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 137) (:start . 135)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 138) (:start . 137)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x5.132.1) (:span 63 66)))\n (:nscopes ((:id . :x5.132.1) (:span 15 113)))\n (:identifiers (:sid . :s5.132) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101542@unknown@formal@none@1@S@Similarly, loss of neur activity had no detectable effect on leg segmentation (data not shown) and vein determination [45], two processes shown here to depend on D-mib gene activity.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 50)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "leg") (:form . "leg") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "segmentation") (:form . "segmentation") (:end . 77)\n  (:start . 65) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "determination") (:form . "determination")\n  (:end . 117) (:start . 104) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 66))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 127) (:start . 124)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 137)\n  (:start . 128) (:id . 68))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 143)\n  (:start . 138) (:id . 69))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 148) (:start . 144)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 151) (:start . 149)\n  (:id . 71))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 158)\n  (:start . 152) (:id . 72))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 161) (:start . 159)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 167)\n  (:start . 162) (:id . 74))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 172) (:start . 168)\n  (:id . 75))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 181)\n  (:start . 173) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x5.133.1) (:span 84 87)) ((:id . :x5.133.2) (:span 37 39)))\n (:nscopes ((:id . :x5.133.1) (:span 78 94))\n  ((:id . :x5.133.2) (:span 37 77)))\n (:identifiers (:sid . :s5.133) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101543@unknown@formal@none@1@S@We therefore conclude that D-mib and neur have distinct and complementary functions in Drosophila.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 73) (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 97)\n  (:start . 87) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s5.134) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101544@unknown@formal@none@1@S@D-mib Co-Localizes with Dl and Ser at the Apical Cortex@(((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Co-Localiz") (:form . "Co-Localizes") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Apical") (:form . "Apical") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "Cortex") (:form . "Cortex") (:end . 55)\n  (:start . 49) (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.135) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101545@unknown@formal@none@1@S@We next studied the subcellular localization of D-mib (Figure 3).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 31)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 44)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.136) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101546@unknown@formal@none@1@S@Anti-D-mib antibodies were generated that specifically detected D-mib on Western blots (see Figure 1C) and on fixed tissues (Figure 3F–F?).@(((:tag . "JJ") (:stem . "anti-d-mib") (:form . "Anti-D-mib") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 54)\n  (:start . 42) (:id . 47))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 63)\n  (:start . 55) (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 69) (:start . 64)\n  (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 72) (:start . 70)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "western") (:form . "Western") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "NNS") (:stem . "blot") (:form . "blots") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 91) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 98)\n  (:start . 92) (:id . 55))\n ((:tag . "NN") (:stem . "1c") (:form . "1C") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "fix") (:form . "fixed") (:end . 115) (:start . 110)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 123)\n  (:start . 116) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "NNP") (:stem . "3F–F") (:form . "3F–F") (:end . 136) (:start . 132)\n  (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 137) (:start . 136)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s5.137) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101547@unknown@formal@none@1@S@Using these antibodies, we found that D-mib was detected in all imaginal disc cells (Figure 3A and 3B).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 22)\n  (:start . 12) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "disc") (:form . "disc") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 91)\n  (:start . 85) (:id . 58))\n ((:tag . "NN") (:stem . "3a") (:form . "3A") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "3b") (:form . "3B") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s5.138) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101548@unknown@formal@none@1@S@We then examined D-mib subcellular distribution in epithelial cells located along the edge of the wing discs because cross-sectional imaging affords better resolution along the apical-basal axis.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 47)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 61)\n  (:start . 51) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 75)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 81) (:start . 76)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "edge") (:form . "edge") (:end . 90) (:start . 86)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "cross-sectional") (:form . "cross-sectional")\n  (:end . 132) (:start . 117) (:id . 60))\n ((:tag . "NN") (:stem . "imaging") (:form . "imaging") (:end . 140)\n  (:start . 133) (:id . 61))\n ((:tag . "NNS") (:stem . "afford") (:form . "affords") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 155)\n  (:start . 149) (:id . 63))\n ((:tag . "NN") (:stem . "resolution") (:form . "resolution") (:end . 166)\n  (:start . 156) (:id . 64))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 172)\n  (:start . 167) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "apical-basal") (:form . "apical-basal") (:end . 189)\n  (:start . 177) (:id . 67))\n ((:tag . "NN") (:stem . "axis") (:form . "axis") (:end . 194) (:start . 190)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s5.139) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101550@unknown@formal@none@1@S@Dl and Ser were also detected in large intracellular vesicles that probably correspond to multivesicular bodies in that they also stained for hepatocyte growth factor-regulated tyrosine kinase substrate [46] (Figure 3B–3C'''???; data not shown).@(((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 45))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 52) (:start . 39) (:id . 50))\n ((:tag . "NNS") (:stem . "vesicle") (:form . "vesicles") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBP") (:stem . "correspond") (:form . "correspond") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multivesicular") (:form . "multivesicular")\n  (:end . 104) (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "body") (:form . "bodies") (:end . 111)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 124) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "stain") (:form . "stained") (:end . 137)\n  (:start . 130) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "hepatocyte") (:form . "hepatocyte") (:end . 152)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 159)\n  (:start . 153) (:id . 65))\n ((:tag . "JJ") (:stem . "factor-regulated") (:form . "factor-regulated")\n  (:end . 176) (:start . 160) (:id . 66))\n ((:tag . "NN") (:stem . "tyrosine") (:form . "tyrosine") (:end . 185)\n  (:start . 177) (:id . 67))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 192)\n  (:start . 186) (:id . 68))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 202)\n  (:start . 193) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 204) (:start . 203)\n  (:id . 70))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 207) (:start . 206)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 209) (:start . 208)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 215)\n  (:start . 209) (:id . 74))\n ((:tag . "NNP") (:stem . "3B–3C") (:form . "3B–3C") (:end . 221)\n  (:start . 216) (:id . 75))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 221) (:start . 221)\n  (:id . 76))\n ((:tag . "''") (:stem . "’") (:form . "’") (:end . 224) (:start . 223)\n  (:id . 77))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 225) (:start . 224)\n  (:id . 78))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 226) (:start . 225)\n  (:id . 79))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 227) (:start . 226)\n  (:id . 80))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 228) (:start . 227)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 233)\n  (:start . 229) (:id . 82))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 237) (:start . 234)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 243)\n  (:start . 238) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 244) (:start . 243)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x5.141.1) (:span 67 75)))\n (:hscopes ((:id . :x5.141.1) (:span 67 202)))\n (:identifiers (:sid . :s5.141) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101551@unknown@formal@none@1@S@The intracellular dots seen with the anti-D-mib antibodies were distinct from the Dl- and Ser-positive dots and appeared to result from background staining (data not shown).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "dot") (:form . "dots") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-d-mib") (:form . "anti-D-mib") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dl-") (:form . "Dl-") (:end . 85) (:start . 82)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "ser-positive") (:form . "Ser-positive") (:end . 102)\n  (:start . 90) (:id . 56))\n ((:tag . "NNS") (:stem . "dot") (:form . "dots") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 120)\n  (:start . 112) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 135) (:start . 131)\n  (:id . 62))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 155)\n  (:start . 147) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 161)\n  (:start . 157) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 165) (:start . 162)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 171)\n  (:start . 166) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x5.142.1) (:span 112 120)))\n (:hscopes ((:id . :x5.142.1) (:span 112 155)))\n (:identifiers (:sid . :s5.142) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101552@unknown@formal@none@1@S@The reduced cytoplasmic staining seen in D-mib mutant cells (Figure 3F–3F??)'' suggests that D-mib is also present in the cytoplasm.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "cytoplasmic") (:form . "cytoplasmic") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "3F–3F") (:form . "3F–3F") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 76) (:start . 76)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 106) (:start . 102)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 131)\n  (:start . 122) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x5.143.1) (:span 79 87)))\n (:hscopes ((:id . :x5.143.1) (:span 79 131)))\n (:identifiers (:sid . :s5.143) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101553@unknown@formal@none@1@S@A similar localization at the apical cortex and in the cytoplasm was seen for a functional yellow fluorescent protein (YFP)::D-mib fusion protein (see Figure 6 below).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "fluorescent") (:form . "fluorescent") (:end . 109)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "YFP)::D-mib") (:form . "YFP)::D-mib") (:end . 130)\n  (:start . 119) (:id . 62))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 147) (:start . 146)\n  (:id . 65))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 157)\n  (:start . 151) (:id . 67))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 165)\n  (:start . 160) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.144) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101554@unknown@formal@none@1@S@These localization data suggest that D-mib may act at the apical cortex to regulate the activity of Dl and/or Ser.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 109)\n  (:start . 103) (:id . 60))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 113) (:start . 110)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x5.145.1) (:span 43 46)) ((:id . :x5.145.2) (:span 24 31)))\n (:hscopes ((:id . :x5.145.1) (:span 43 113))\n  ((:id . :x5.145.2) (:span 24 113)))\n (:identifiers (:sid . :s5.145) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101555@unknown@formal@none@1@S@D-mib Co-Localizes with Dl and Ser at the Apical Cell Cortex@(((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Co-Localiz") (:form . "Co-Localizes") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Apical") (:form . "Apical") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "Cell") (:form . "Cell") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Cortex") (:form . "Cortex") (:end . 60)\n  (:start . 54) (:id . 52)))@@@1@11@((:identifiers (:sid . :s5.146) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101556@unknown@formal@none@1@S@(A and A?) D-mib (green) is detected in all cells of the wing imaginal disc.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 16) (:start . 11)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 23) (:start . 18)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 36)\n  (:start . 28) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 43) (:start . 40)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 49) (:start . 44)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 61) (:start . 57)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 70)\n  (:start . 62) (:id . 60))\n ((:tag . "NN") (:stem . "disc") (:form . "disc") (:end . 75) (:start . 71)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s5.147) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101557@unknown@formal@none@1@S@In (A), Ser is in red and Discs-large (Dlg) is in blue.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 4) (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 5) (:start . 4)\n  (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 11) (:start . 8)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 21) (:start . 18)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "discs-large") (:form . "Discs-large") (:end . 37)\n  (:start . 26) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Dlg") (:form . "Dlg") (:end . 42) (:start . 39)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 43) (:start . 42)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 57))\n ((:tag . "NN") (:stem . "blue") (:form . "blue") (:end . 54) (:start . 50)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.148) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101558@unknown@formal@none@1@S@(B–D???) D-mib (green in B, B?, C, C?, D, and D?) co-localized with Ser (red in [B and B??]), Dl (red in [C and C??]), N (red in [D and D??]), and E-Cadherin (E-Cad; blue in [D and D???]) and was found apical to Discs-large (Dlg; blue in [B, B???, C, and C???]) in notum cells located at the edges of the wing discs.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "b–d") (:form . "B–D") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 8) (:start . 7) (:id . 47))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 14) (:start . 9)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 21) (:start . 16)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 26) (:start . 25)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 29) (:start . 28)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 30) (:start . 29)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 31) (:start . 30)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 33) (:start . 32)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 36) (:start . 35)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 37) (:start . 36)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 40) (:start . 39)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 47) (:start . 46)\n  (:id . 65))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 48) (:start . 47)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "co-localize") (:form . "co-localized") (:end . 62)\n  (:start . 50) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 71) (:start . 68)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 76) (:start . 73)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 73))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 81) (:start . 80)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 82) (:start . 81)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 88) (:start . 87)\n  (:id . 77))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 89) (:start . 88)\n  (:id . 78))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 90) (:start . 89)\n  (:id . 79))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 91) (:start . 90)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 82))\n ((:tag . "NN") (:stem . "dl") (:form . "Dl") (:end . 96) (:start . 94)\n  (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 101) (:start . 98)\n  (:id . 85))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 86))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 106) (:start . 105)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 107) (:start . 106)\n  (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 113) (:start . 112)\n  (:id . 90))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 114) (:start . 113)\n  (:id . 91))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 115) (:start . 114)\n  (:id . 92))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 116) (:start . 115)\n  (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 94))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 120) (:start . 119)\n  (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 97))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 125) (:start . 122)\n  (:id . 98))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 99))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 130) (:start . 129)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 131) (:start . 130)\n  (:id . 101))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 102))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 137) (:start . 136)\n  (:id . 103))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 138) (:start . 137)\n  (:id . 104))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 139) (:start . 138)\n  (:id . 105))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 140) (:start . 139)\n  (:id . 106))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 107))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 108))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 109))\n ((:tag . "NNP") (:stem . "E-Cadherin") (:form . "E-Cadherin") (:end . 157)\n  (:start . 147) (:id . 110))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 111))\n ((:tag . "NNP") (:stem . "E-Cad") (:form . "E-Cad") (:end . 164)\n  (:start . 159) (:id . 112))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 165) (:start . 164)\n  (:id . 113))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 170) (:start . 166)\n  (:id . 114))\n ((:tag . "IN") (:stem . 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5101560@unknown@formal@none@1@S@(F–F??) D-mib staining at the apical cortex (blue in [F and F?]) was not detected in D-mib2 mutant clone (marked by loss of nuclear GFP staining; green in [F]).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "F–F") (:form . "F–F") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 13) (:start . 8)\n  (:id . 47))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 22)\n  (:start . 14) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 25) (:start . 23)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 36)\n  (:start . 30) (:id . 51))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 43)\n  (:start . 37) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 49) (:start . 45)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 54) (:start . 53)\n  (:id . 56))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 55) (:start . 54)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 58))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 61) (:start . 60)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 62) (:start . 61)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 63) (:start . 62)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 68) (:start . 65)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 72) (:start . 69)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 81)\n  (:start . 73) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 66))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 91)\n  (:start . 85) (:id . 67))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 98)\n  (:start . 92) (:id . 68))\n ((:tag . "NN") (:stem . "clone") (:form . "clone") (:end . 104) (:start . 99)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 112)\n  (:start . 106) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 72))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 120) (:start . 116)\n  (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 131)\n  (:start . 124) (:id . 75))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 135) (:start . 132)\n  (:id . 76))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 144)\n  (:start . 136) (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 145) (:start . 144)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 151)\n  (:start . 146) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 156) (:start . 155)\n  (:id . 81))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 157) (:start . 156)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 158) (:start . 157)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 160) (:start . 159)\n  (:id . 85)))@@@1@44@((:ncues ((:id . :x5.151.1) (:span 69 72)))\n (:nscopes ((:id . :x5.151.1) (:span 0 144)))\n (:identifiers (:sid . :s5.151) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101561@unknown@formal@none@1@S@Loss of D-mib activity has no detectable effect on the apical accumulation of Dl (red in [F and F??]).@(((:tag . "NN") (:stem . "loss") (:form . "Loss") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 97) (:start . 96)\n  (:id . 62))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 98) (:start . 97)\n  (:id . 63))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 99) (:start . 98)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 100) (:start . 99)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x5.152.1) (:span 27 29)))\n (:nscopes ((:id . :x5.152.1) (:span 27 80)))\n (:identifiers (:sid . :s5.152) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101562@unknown@formal@none@1@S@Bar is 50 ?m for (A and A?) and 10 ?m for (B–F??).@(((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 19) (:start . 18)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 49))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 25) (:start . 24)\n  (:id . 50))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 26) (:start . 25)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 27) (:start . 26)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 53))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 34) (:start . 32)\n  (:id . 54))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 37) (:start . 35)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B–F") (:form . "B–F") (:end . 46) (:start . 43)\n  (:id . 58))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 47) (:start . 46)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 48) (:start . 47)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s5.153) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101563@unknown@formal@none@1@S@D-mib Is Required in Dorsal Cells for Margin Expression of Cut@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "Required") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Dorsal") (:form . "Dorsal") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "Cells") (:form . "Cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Margin") (:form . "Margin") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 62) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s5.154) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101564@unknown@formal@none@1@S@Large dorsal clones of D-mib2 mutant cells (marked by the loss of nuclear GFP, in green) resulted in a complete loss of Cut (red) expression (A and B).@(((:tag . "JJ") (:stem . "large") (:form . "Large") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 50) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 87) (:start . 82)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 97)\n  (:start . 89) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 102) (:start . 101)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 111)\n  (:start . 103) (:id . 64))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 116) (:start . 112)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 123) (:start . 120)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 125) (:start . 124)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 128) (:start . 125)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 140)\n  (:start . 130) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 143) (:start . 142)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 149) (:start . 148)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s5.155) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101565@unknown@formal@none@1@S@This indicates that D-mib is required for Ser signaling by dorsal cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x5.156.1) (:span 5 19)))\n (:hscopes ((:id . :x5.156.1) (:span 5 71)))\n (:identifiers (:sid . :s5.156) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101566@unknown@formal@none@1@S@In contrast, ventral clones did not prevent the expression of Cut (C and D), implying that D-mib is not strictly required for Dl signaling.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "imply") (:form . "implying") (:end . 85)\n  (:start . 77) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 96) (:start . 91)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 63))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 103) (:start . 100)\n  (:id . 64))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 112)\n  (:start . 104) (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 121)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 128) (:start . 126)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 138)\n  (:start . 129) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x5.157.1) (:span 77 85)))\n (:ncues ((:id . :x5.157.2) (:span 32 35)))\n (:hscopes ((:id . :x5.157.1) (:span 77 138)))\n (:nscopes ((:id . :x5.157.2) (:span 32 75)))\n (:identifiers (:sid . :s5.157) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101567@unknown@formal@none@1@S@Note that mutant ventral cells abutting wild-type dorsal cells expressed Cut (arrow in [D]), indicating that D-mib is not required for N signal transduction.@(((:tag . "VB") (:stem . "note") (:form . "Note") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "abut") (:form . "abutting") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 49)\n  (:start . 40) (:id . 48))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 62) (:start . 57)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "arrow") (:form . "arrow") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 90) (:start . 89)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 103)\n  (:start . 93) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 108) (:start . 104)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 121) (:start . 118)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 130)\n  (:start . 122) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 134) (:start . 131)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 143)\n  (:start . 137) (:id . 69))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 156)\n  (:start . 144) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x5.158.2) (:span 93 108)))\n (:ncues ((:id . :x5.158.1) (:span 118 121)))\n (:hscopes ((:id . :x5.158.2) (:span 93 156)))\n (:nscopes ((:id . :x5.158.1) (:span 109 156)))\n (:identifiers (:sid . :s5.158) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101568@unknown@formal@none@1@S@Low-magnification views of the wing portion of the discs are shown in (A) and (C).@(((:tag . "JJ") (:stem . "low-magnification") (:form . "Low-magnification")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "view") (:form . "views") (:end . 23) (:start . 18)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.159) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101570@unknown@formal@none@1@S@D-mib Regulates the Cell-Surface Level of Ser@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "Regulates") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Cell-Surface") (:form . "Cell-Surface") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "NNP") (:stem . "Level") (:form . "Level") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 45) (:start . 42)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s5.161) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101571@unknown@formal@none@1@S@We next examined the potential role of D-mib in regulating Dl and Ser distribution in wing imaginal discs.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 58)\n  (:start . 48) (:id . 51))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 82)\n  (:start . 70) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 99)\n  (:start . 91) (:id . 58))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x5.162.1) (:span 21 30)))\n (:hscopes ((:id . :x5.162.1) (:span 21 105)))\n (:identifiers (:sid . :s5.162) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101572@unknown@formal@none@1@S@We focused our analysis on the notum region since D-mib mutant discs have no wing pouch (Figure 4).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "focus") (:form . "focused") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "notum") (:form . "notum") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 55) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x5.163.1) (:span 74 76)))\n (:nscopes ((:id . :x5.163.1) (:span 74 87)))\n (:identifiers (:sid . :s5.163) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101573@unknown@formal@none@1@S@Dl and Ser co-localized both at the apical cortex and in large intracellular vesicles in wild-type cells (Figure 4A–4C?).@(((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "co-localize") (:form . "co-localized") (:end . 23)\n  (:start . 11) (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 62) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 76) (:start . 63) (:id . 54))\n ((:tag . "NNS") (:stem . "vesicle") (:form . "vesicles") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "4A–4C") (:form . "4A–4C") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.164) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101574@unknown@formal@none@1@S@The complete loss of D-mib activity in D-mib1 mutant discs did not detectably change the subcellular localization of Dl (Figure 4C, 4C?, 4F, and 4F?).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "RB") (:stem . "detectably") (:form . "detectably") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "VB") (:stem . "change") (:form . "change") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 113)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 127)\n  (:start . 121) (:id . 62))\n ((:tag . "NN") (:stem . "4c") (:form . "4C") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "4c") (:form . "4C") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "4f") (:form . "4F") (:end . 139) (:start . 137)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 70))\n ((:tag . "NN") (:stem . "4f") (:form . "4F") (:end . 147) (:start . 145)\n  (:id . 71))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 148) (:start . 147)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x5.165.1) (:span 63 66)))\n (:nscopes ((:id . :x5.165.1) (:span 63 119)))\n (:identifiers (:sid . :s5.165) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101575@unknown@formal@none@1@S@In contrast, the accumulation of Ser at the apical cortex was strongly increased (Figure 4E) and Ser accumulation in Dl-positive vesicles was dramatically reduced (Figure 4E?) in D-mib1 mutant discs.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "4e") (:form . "4E") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 113)\n  (:start . 101) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dl-positive") (:form . "Dl-positive") (:end . 128)\n  (:start . 117) (:id . 64))\n ((:tag . "NNS") (:stem . "vesicle") (:form . "vesicles") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 154)\n  (:start . 142) (:id . 67))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "NNP") (:stem . "4E") (:form . "4E") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 185)\n  (:start . 179) (:id . 75))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 192)\n  (:start . 186) (:id . 76))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 198)\n  (:start . 193) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s5.166) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101576@unknown@formal@none@1@S@Similar results were also obtained in D-mib2 mutant clones, which showed strongly elevated levels of cortical Ser (Figure 4H) whereas the amount of Dl at the apical cortex was not detectably modified (see Figures 3F–3F?? and 4J).@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 72) (:start . 66)\n  (:id . 53))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 90)\n  (:start . 82) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "cortical") (:form . "cortical") (:end . 109)\n  (:start . 101) (:id . 58))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "4h") (:form . "4H") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "amount") (:form . "amount") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 164)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 171)\n  (:start . 165) (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 175) (:start . 172)\n  (:id . 73))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "RB") (:stem . "detectably") (:form . "detectably") (:end . 190)\n  (:start . 180) (:id . 75))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 199)\n  (:start . 191) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 77))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 204) (:start . 201)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 212)\n  (:start . 205) (:id . 79))\n ((:tag . "NNP") (:stem . "3F–3F") (:form . "3F–3F") (:end . 218)\n  (:start . 213) (:id . 80))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 219) (:start . 218)\n  (:id . 81))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 220) (:start . 219)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 83))\n ((:tag . "NN") (:stem . "4j") (:form . "4J") (:end . 227) (:start . 225)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x5.167.1) (:span 176 179)))\n (:nscopes ((:id . :x5.167.1) (:span 134 199)))\n (:identifiers (:sid . :s5.167) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101577@unknown@formal@none@1@S@Of note, loss of D-mib2 activity in clones did not block the accumulation of Ser into intracellular dots (Figure 4H?).@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 32)\n  (:start . 24) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 42)\n  (:start . 36) (:id . 50))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 56) (:start . 51)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 73)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 99) (:start . 86) (:id . 59))\n ((:tag . "NNS") (:stem . "dot") (:form . "dots") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "NN") (:stem . "4h") (:form . "4H") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x5.168.1) (:span 47 50)))\n (:nscopes ((:id . :x5.168.1) (:span 47 104)))\n (:identifiers (:sid . :s5.168) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101578@unknown@formal@none@1@S@Thus, trafficking of Ser towards this intracellular compartment is, at least in part, D-mib-independent.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "trafficking") (:form . "trafficking") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "d-mib-independent") (:form . "D-mib-independent")\n  (:end . 103) (:start . 86) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.169) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101580@unknown@formal@none@1@S@D-mib Is Required to Down-Regulate Ser at the Apical Cortex@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "Required") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "down-regulate") (:form . "Down-Regulate")\n  (:end . 34) (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Apical") (:form . "Apical") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "Cortex") (:form . "Cortex") (:end . 59)\n  (:start . 53) (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.171) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101581@unknown@formal@none@1@S@(A–F?) Distribution of Dl (green) and Ser (red) in the notum region of wild-type (A–C?) and D-mib1 mutant (D–F?) wing imaginal discs.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A–F") (:form . "A–F") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . "NN") (:stem . "distribution") (:form . "Distribution") (:end . 19)\n  (:start . 7) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "NN") (:stem . "green") (:form . "green") (:end . 32) (:start . 27)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 33) (:start . 32)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 41) (:start . 38)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 54))\n ((:tag . "NN") (:stem . "red") (:form . "red") (:end . 46) (:start . 43)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 58))\n ((:tag . "NN") (:stem . "notum") (:form . "notum") (:end . 60) (:start . 55)\n  (:id . 59))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 67)\n  (:start . 61) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 80)\n  (:start . 71) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "A–C") (:form . "A–C") (:end . 85) (:start . 82)\n  (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 86) (:start . 85)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 67))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 98)\n  (:start . 92) (:id . 68))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 105)\n  (:start . 99) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "D–F") (:form . "D–F") (:end . 110) (:start . 107)\n  (:id . 71))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 111) (:start . 110)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 117) (:start . 113)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 126)\n  (:start . 118) (:id . 75))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 132)\n  (:start . 127) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s5.172) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101582@unknown@formal@none@1@S@The boxed areas in (A) and (D) are shown at higher magnification in (B–F?).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "box") (:form . "boxed") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 22) (:start . 21)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 29) (:start . 28)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 40) (:start . 35)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 50) (:start . 44)\n  (:id . 56))\n ((:tag . "NN") (:stem . "magnification") (:form . "magnification")\n  (:end . 64) (:start . 51) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B–F") (:form . "B–F") (:end . 72) (:start . 69)\n  (:id . 60))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 73) (:start . 72)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s5.173) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101583@unknown@formal@none@1@S@The specific loss of Ser accumulation into intracellular vesicles (compare [E?] with [B?]) correlated with the elevated levels of Ser seen at the apical cortex of D-mib mutant cells (compare [E] with [B]).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 56) (:start . 43) (:id . 49))\n ((:tag . "NNS") (:stem . "vesicle") (:form . "vesicles") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "NN") (:stem . "compare") (:form . "compare") (:end . 74)\n  (:start . 67) (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 87) (:start . 86)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 89) (:start . 88)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 90) (:start . 89)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 101)\n  (:start . 91) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 119)\n  (:start . 111) (:id . 66))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 126)\n  (:start . 120) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 133) (:start . 130)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 138) (:start . 134)\n  (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 141) (:start . 139)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 152)\n  (:start . 146) (:id . 73))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 159)\n  (:start . 153) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 168)\n  (:start . 163) (:id . 76))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 175)\n  (:start . 169) (:id . 77))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 181)\n  (:start . 176) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 79))\n ((:tag . "NN") (:stem . "compare") (:form . "compare") (:end . 190)\n  (:start . 183) (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 192) (:start . 191)\n  (:id . 81))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 193) (:start . 192)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 194) (:start . 193)\n  (:id . 83))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 84))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 201) (:start . 200)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 202) (:start . 201)\n  (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 203) (:start . 202)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s5.174) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101584@unknown@formal@none@1@S@(G–J?) Ser (red in [H and H?]) accumulated at the apical cortex (H) as well as in intracellular dots (H?) in D-mib2 mutant cells (marked by the loss of nuclear GFP; green in [G]).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "g–j") (:form . "G–J") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 10) (:start . 7)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 12) (:start . 11)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 15) (:start . 12)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 18) (:start . 16)\n  (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 20) (:start . 19)\n  (:id . 50))\n ((:tag . 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".") (:end . 179) (:start . 178)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s5.175) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101585@unknown@formal@none@1@S@Cut is shown in blue (G).@(((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 20) (:start . 16)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 23) (:start . 22)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 25) (:start . 24)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s5.176) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101586@unknown@formal@none@1@S@The distribution of Dl (red in [J and J?]) was not affected by the loss of D-mib activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 33) (:start . 32)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 39) (:start . 38)\n  (:id . 52))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 40) (:start . 39)\n  (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 41) (:start . 40)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 42) (:start . 41)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 46) (:start . 43)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 59)\n  (:start . 51) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 60))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 71) (:start . 67)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 80) (:start . 75)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 89)\n  (:start . 81) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x5.177.1) (:span 47 50)))\n (:nscopes ((:id . :x5.177.1) (:span 0 89)))\n (:identifiers (:sid . :s5.177) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101587@unknown@formal@none@1@S@Low-magnification views of the wing portion of the discs are shown in (G) and (I).@(((:tag . "JJ") (:stem . "low-magnification") (:form . "Low-magnification")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "view") (:form . "views") (:end . 23) (:start . 18)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 58))\n ((:tag . "LS") (:stem . "i") (:form . "I") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.178) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101588@unknown@formal@none@1@S@(H and H?) and (J and J?) show high magnification views of the areas boxed in (G) and (I), respectively.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 10) (:start . 9)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 14) (:start . 11)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 17) (:start . 16)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 23) (:start . 22)\n  (:id . 52))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 24) (:start . 23)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 30) (:start . 26)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 35) (:start . 31)\n  (:id . 56))\n ((:tag . "NN") (:stem . "magnification") (:form . "magnification")\n  (:end . 49) (:start . 36) (:id . 57))\n ((:tag . "NNS") (:stem . "view") (:form . "views") (:end . 55) (:start . 50)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 68) (:start . 63)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "box") (:form . "boxed") (:end . 74) (:start . 69)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 77) (:start . 75)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 80) (:start . 79)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 68))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 88) (:start . 87)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 89) (:start . 88)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 71))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 103)\n  (:start . 91) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s5.179) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101590@unknown@formal@none@1@S@Bar is 40 ?m for (A, D, G), 5 ?m for (B–C? and E–F?), and 10 ?m for (H–J?).@(((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 19) (:start . 18)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 22) (:start . 21)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 25) (:start . 24)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 26) (:start . 25)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 54))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 29) (:start . 28)\n  (:id . 55))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 32) (:start . 30)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B–C") (:form . "B–C") (:end . 41) (:start . 38)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 42) (:start . 41)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "E–F") (:form . "E–F") (:end . 50) (:start . 47)\n  (:id . 62))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 51) (:start . 50)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 66))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 60) (:start . 58)\n  (:id . 67))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 63) (:start . 61)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 67) (:start . 64)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "H–J") (:form . "H–J") (:end . 72) (:start . 69)\n  (:id . 71))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 73) (:start . 72)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s5.181) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101591@unknown@formal@none@1@S@D-mib Is Required for Ser Endocytosis@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "Required") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Endocytosis") (:form . "Endocytosis") (:end . 37)\n  (:start . 26) (:id . 47)))@@@1@6@((:identifiers (:sid . :s5.182) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101592@unknown@formal@none@1@S@Ubiquitin-mediated endocytosis is thought to depend on monoubiquitination.@(((:tag . "JJ") (:stem . "ubiquitin-mediated") (:form . "Ubiquitin-mediated")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 30)\n  (:start . 19) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 33) (:start . 31)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 41)\n  (:start . 34) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "VB") (:stem . "depend") (:form . "depend") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "NN") (:stem . "monoubiquitination") (:form . "monoubiquitination")\n  (:end . 73) (:start . 55) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 50)))@@@1@9@((:hcues ((:id . :x5.183.1) (:span 34 41)))\n (:hscopes ((:id . :x5.183.1) (:span 0 73)))\n (:identifiers (:sid . :s5.183) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101593@unknown@formal@none@1@S@Thus, by analogy with the function of Mib in D. rerio [18,28], we suggest that D-mib may directly monoubiquitinate Ser.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analogy") (:form . "analogy") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 41) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 47) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 53) (:start . 48)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 55) (:start . 54)\n  (:id . 54))\n ((:tag . "CD") (:stem . "18,28") (:form . "18,28") (:end . 60) (:start . 55)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 61) (:start . 60)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 73)\n  (:start . 66) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 84) (:start . 79)\n  (:id . 61))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 88) (:start . 85)\n  (:id . 62))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 97)\n  (:start . 89) (:id . 63))\n ((:tag . "VB") (:stem . "monoubiquitinate") (:form . "monoubiquitinate")\n  (:end . 114) (:start . 98) (:id . 64))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x5.184.1) (:span 85 88)) ((:id . :x5.184.2) (:span 66 73)))\n (:hscopes ((:id . :x5.184.1) (:span 85 118))\n  ((:id . :x5.184.2) (:span 66 118)))\n (:identifiers (:sid . :s5.184) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101594@unknown@formal@none@1@S@Consistent with this hypothesis, we show in a companion paper that D-mib binds Ser (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data).@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "companion") (:form . "companion") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Lai") (:form . "Lai") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 97) (:start . 95)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Roegiers") (:form . "Roegiers") (:end . 106)\n  (:start . 98) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "X.") (:form . "X.") (:end . 110) (:start . 108)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Qin") (:form . "Qin") (:end . 114) (:start . 111)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 118) (:start . 116)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Le") (:form . "Le") (:end . 121) (:start . 119)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Borgne") (:form . "Borgne") (:end . 128)\n  (:start . 122) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 132) (:start . 130)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Schweisguth") (:form . "Schweisguth") (:end . 144)\n  (:start . 133) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 74))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 148) (:start . 146)\n  (:id . 75))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 152) (:start . 149)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 165)\n  (:start . 154) (:id . 78))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 170)\n  (:start . 166) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s5.185) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101595@unknown@formal@none@1@S@Moreover, a mutation in the C-terminal catalytic RING domain of D-mib abolished its ability to internalize Ser in transfected S2 cells (R. L. B. and F. S., unpublished data) implying that the E3 ubiquitin ligase activity of D-mib is required for Ser internalization.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "abolish") (:form . "abolished") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "VB") (:stem . "internalize") (:form . "internalize") (:end . 106)\n  (:start . 95) (:id . 58))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 110) (:start . 107)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transfecte") (:form . "transfected") (:end . 125)\n  (:start . 114) (:id . 61))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 128) (:start . 126)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 134)\n  (:start . 129) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "L.") (:form . "L.") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B.") (:form . "B.") (:end . 144) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 154) (:start . 152)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 167)\n  (:start . 156) (:id . 72))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 172)\n  (:start . 168) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "imply") (:form . "implying") (:end . 182)\n  (:start . 174) (:id . 75))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 77))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 194) (:start . 192)\n  (:id . 78))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 204)\n  (:start . 195) (:id . 79))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 211)\n  (:start . 205) (:id . 80))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 220)\n  (:start . 212) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 223) (:start . 221)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 229)\n  (:start . 224) (:id . 83))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 232) (:start . 230)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 241)\n  (:start . 233) (:id . 85))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 245) (:start . 242)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 249) (:start . 246)\n  (:id . 87))\n ((:tag . "NN") (:stem . "internalization") (:form . "internalization")\n  (:end . 265) (:start . 250) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x5.186.1) (:span 174 182)))\n (:hscopes ((:id . :x5.186.1) (:span 174 265)))\n (:identifiers (:sid . :s5.186) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101596@unknown@formal@none@1@S@Biochemical analysis of the ubiquitination events regulated by D-mib will be needed to further define the mechanism by which D-mib regulates the endocytosis of Ser in vivo.@(((:tag . "JJ") (:stem . "biochemical") (:form . "Biochemical") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 20)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 42) (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 49)\n  (:start . 43) (:id . 47))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 59)\n  (:start . 50) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 62) (:start . 60)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 68) (:start . 63)\n  (:id . 50))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "need") (:form . "needed") (:end . 83) (:start . 77)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "VB") (:stem . "define") (:form . "define") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 57))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 124)\n  (:start . 119) (:id . 60))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 130)\n  (:start . 125) (:id . 61))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 140)\n  (:start . 131) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 156)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 67))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 171) (:start . 167)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s5.187) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101597@unknown@formal@none@1@S@To test whether this specific increase in the level of Ser at the apical cortex resulted from reduced Ser endocytosis in D-mib mutant cells, we followed the endocytosis of Ser in living imaginal discs using an antibody uptake assay.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 126)\n  (:start . 121) (:id . 63))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 133)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "follow") (:form . "followed") (:end . 152)\n  (:start . 144) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 168)\n  (:start . 157) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 175) (:start . 172)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 185)\n  (:start . 179) (:id . 74))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 194)\n  (:start . 186) (:id . 75))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 200)\n  (:start . 195) (:id . 76))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 206) (:start . 201)\n  (:id . 77))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 209) (:start . 207)\n  (:id . 78))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 218)\n  (:start . 210) (:id . 79))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 225)\n  (:start . 219) (:id . 80))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 231)\n  (:start . 226) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x5.188.1) (:span 8 15)))\n (:hscopes ((:id . :x5.188.1) (:span 8 139)))\n (:identifiers (:sid . :s5.188) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101598@unknown@formal@none@1@S@Briefly, dissected wing discs were cultured for 15 min in the presence of antibodies that recognize the extracellular part of Ser or Dl, then washed, cultured for another 45 min in medium without antibodies, and then fixed.@(((:tag . "NNP") (:stem . "Briefly") (:form . "Briefly") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "dissect") (:form . "dissected") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 70)\n  (:start . 62) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "recognize") (:form . "recognize") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 117) (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 132) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 141) (:start . 137)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "wash") (:form . "washed") (:end . 148)\n  (:start . 142) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 158)\n  (:start . 150) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 162) (:start . 159)\n  (:id . 71))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 170)\n  (:start . 163) (:id . 72))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 177) (:start . 174)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 180) (:start . 178)\n  (:id . 75))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 187)\n  (:start . 181) (:id . 76))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 195)\n  (:start . 188) (:id . 77))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 206)\n  (:start . 196) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 80))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 216) (:start . 212)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "fix") (:form . "fixed") (:end . 222) (:start . 217)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x5.189.1) (:span 188 195)))\n (:nscopes ((:id . :x5.189.1) (:span 188 206)))\n (:identifiers (:sid . :s5.189) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101600@unknown@formal@none@1@S@The results are shown in Figure 5.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 34) (:start . 33)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s5.191) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101601@unknown@formal@none@1@S@Using this assay, we found that anti-Ser-and anti-Dl antibodies were internalized in wild-type epithelial cells (Figure 5A–5C??).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "anti-ser-and") (:form . "anti-Ser-and") (:end . 44)\n  (:start . 32) (:id . 49))\n ((:tag . "JJ") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "internalize") (:form . "internalized") (:end . 81)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 94)\n  (:start . 85) (:id . 55))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 105)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "NNP") (:stem . "5A–5C") (:form . "5A–5C") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s5.192) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101602@unknown@formal@none@1@S@The complete loss of D-mib activity in D-mib1 wing discs did not significantly change the internalization of anti-Dl antibodies (Figure 5D''??, 5E''??, and 5F??)'', indicating that D-mib is not required for Dl endocytosis in this tissue.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "VB") (:stem . "change") (:form . "change") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "internalization") (:form . "internalization")\n  (:end . 105) (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 127)\n  (:start . 117) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "CD") (:stem . "5D") (:form . "5D") (:end . 138) (:start . 136)\n  (:id . 63))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 138) (:start . 138)\n  (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "CD") (:stem . "5E") (:form . "5E") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 146) (:start . 146)\n  (:id . 69))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 151) (:start . 150)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 73))\n ((:tag . "NN") (:stem . "5f") (:form . "5F") (:end . 158) (:start . 156)\n  (:id . 74))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 159) (:start . 158)\n  (:id . 75))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 160) (:start . 159)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 77))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 161) (:start . 161)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 175)\n  (:start . 165) (:id . 80))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 180) (:start . 176)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 186)\n  (:start . 181) (:id . 82))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 189) (:start . 187)\n  (:id . 83))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 193) (:start . 190)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 202)\n  (:start . 194) (:id . 85))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 206) (:start . 203)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 209) (:start . 207)\n  (:id . 87))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 221)\n  (:start . 210) (:id . 88))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 224) (:start . 222)\n  (:id . 89))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 229) (:start . 225)\n  (:id . 90))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 236)\n  (:start . 230) (:id . 91))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 237) (:start . 236)\n  (:id . 92)))@@@1@51@((:hcues ((:id . :x5.193.2) (:span 165 180)))\n (:ncues ((:id . :x5.193.1) (:span 190 193)))\n (:hscopes ((:id . :x5.193.2) (:span 165 236)))\n (:nscopes ((:id . :x5.193.1) (:span 181 236)))\n (:identifiers (:sid . :s5.193) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101603@unknown@formal@none@1@S@However, the loss of D-mib activity strongly inhibited the endocytosis of anti-Ser antibodies (Figure 5E?).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBD") (:stem . "inhibit") (:form . "inhibited") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "NN") (:stem . "5e") (:form . "5E") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.194) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101604@unknown@formal@none@1@S@Moreover, high levels of anti-Ser antibodies were seen at the apical surface (Figure 5D? and 5F?), confirming that D-mib mutant cells accumulate high levels of Ser at their surface.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 76)\n  (:start . 69) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "5d") (:form . "5D") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "5f") (:form . "5F") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 96) (:start . 95)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 97) (:start . 96)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "confirm") (:form . "confirming") (:end . 109)\n  (:start . 99) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 120)\n  (:start . 115) (:id . 66))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 127)\n  (:start . 121) (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 133)\n  (:start . 128) (:id . 68))\n ((:tag . "VBP") (:stem . "accumulate") (:form . "accumulate") (:end . 144)\n  (:start . 134) (:id . 69))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 149) (:start . 145)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 156)\n  (:start . 150) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 163) (:start . 160)\n  (:id . 73))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 166) (:start . 164)\n  (:id . 74))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 172)\n  (:start . 167) (:id . 75))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 180)\n  (:start . 173) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s5.195) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101605@unknown@formal@none@1@S@We therefore conclude that D-mib is specifically required for the endocytosis of Ser in wing discs.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 48)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 61) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 77)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.196) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101606@unknown@formal@none@1@S@D-mib Is Required for Ser Endocytosis@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "require") (:form . "Required") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Endocytosis") (:form . "Endocytosis") (:end . 37)\n  (:start . 26) (:id . 47)))@@@1@6@((:identifiers (:sid . :s5.197) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101607@unknown@formal@none@1@S@Localization of the anti-Ser (red) and anti-Dl (green) antibodies that have been internalized by wild-type (A–C??) and D-mib1 mutant (D–F??) cells in the notum region of wing discs.@(((:tag . "NNP") (:stem . "Localization") (:form . "Localization") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 65)\n  (:start . 55) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "internalize") (:form . "internalized") (:end . 93)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 106)\n  (:start . 97) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "A–C") (:form . "A–C") (:end . 111) (:start . 108)\n  (:id . 62))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 113) (:start . 112)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 66))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 125)\n  (:start . 119) (:id . 67))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 132)\n  (:start . 126) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "D–F") (:form . "D–F") (:end . 137) (:start . 134)\n  (:id . 70))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 138) (:start . 137)\n  (:id . 71))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 139) (:start . 138)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 76))\n ((:tag . "NN") (:stem . "notum") (:form . "notum") (:end . 159)\n  (:start . 154) (:id . 77))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 166)\n  (:start . 160) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 79))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 174) (:start . 170)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 180)\n  (:start . 175) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s5.198) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101608@unknown@formal@none@1@S@(A–A??) and (D–D??) show apical sections and (B–B??) and (E–E??) show basal sections.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A–A") (:form . "A–A") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D–D") (:form . "D–D") (:end . 16) (:start . 13)\n  (:id . 49))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 17) (:start . 16)\n  (:id . 50))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 18) (:start . 17)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 19) (:start . 18)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 24) (:start . 20)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 31)\n  (:start . 25) (:id . 54))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 40)\n  (:start . 32) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "B–B") (:form . "B–B") (:end . 49) (:start . 46)\n  (:id . 58))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 50) (:start . 49)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 51) (:start . 50)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "E–E") (:form . "E–E") (:end . 61) (:start . 58)\n  (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 62) (:start . 61)\n  (:id . 65))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 63) (:start . 62)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 69) (:start . 65)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 75) (:start . 70)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 84)\n  (:start . 76) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.199) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101610@unknown@formal@none@1@S@The z-section axes are shown with a double-headed arrow in (A) and (D).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "z-section") (:form . "z-section") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "ax") (:form . "axes") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "double-headed") (:form . "double-headed")\n  (:end . 49) (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "arrow") (:form . "arrow") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 69) (:start . 68)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.201) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101611@unknown@formal@none@1@S@Internalized anti-Ser and anti-Dl antibodies co-localized in wild-type cells.@(((:tag . "VBN") (:stem . "internalize") (:form . "Internalized") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 44)\n  (:start . 34) (:id . 46))\n ((:tag . "VBN") (:stem . "co-localize") (:form . "co-localized") (:end . 57)\n  (:start . 45) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 70)\n  (:start . 61) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 76) (:start . 71)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.202) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101612@unknown@formal@none@1@S@In contrast, high levels of anti-Ser antibodies were detected at the cell surface of D-mib mutant epithelial cells whereas anti-Dl antibodies were efficiently internalized.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "epithelial") (:form . "epithelial") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "JJ") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 146) (:start . 142)\n  (:id . 64))\n ((:tag . "RB") (:stem . "efficiently") (:form . "efficiently") (:end . 158)\n  (:start . 147) (:id . 65))\n ((:tag . "VBN") (:stem . "internalize") (:form . "internalized") (:end . 171)\n  (:start . 159) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s5.203) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101613@unknown@formal@none@1@S@Bar is 10 ?m for all panels.@(((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "panel") (:form . "panels") (:end . 27)\n  (:start . 21) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 28) (:start . 27)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s5.204) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101614@unknown@formal@none@1@S@D-mib Regulates Ser Signaling@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "Regulates") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Signaling") (:form . "Signaling") (:end . 29)\n  (:start . 20) (:id . 45)))@@@1@4@((:identifiers (:sid . :s5.205) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101615@unknown@formal@none@1@S@The regulation of Ser endocytosis by D-mib suggests that D-mib may regulate Ser signaling.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x5.206.1) (:span 63 66)) ((:id . :x5.206.2) (:span 43 51)))\n (:hscopes ((:id . :x5.206.1) (:span 63 89))\n  ((:id . :x5.206.2) (:span 43 89)))\n (:identifiers (:sid . :s5.206) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101616@unknown@formal@none@1@S@Ser expression is restricted to dorsal cells in second instar wing imaginal discs [7,10,44,47,48].@(((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 54)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "CD") (:stem . "7,10,44,47,48") (:form . "7,10,44,47,48")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s5.207) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101617@unknown@formal@none@1@S@Ser in dorsal cells signals across the D-V boundary to activate N in ventral cells [8,9].@(((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "signal") (:form . "signals") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "CD") (:stem . "8,9") (:form . "8,9") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.208) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101618@unknown@formal@none@1@S@If D-mib is required for Ser signaling during wing development, then loss of D-mib activity in dorsal cells should affect the specification of the wing margin in a non-autonomous manner.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 107)\n  (:start . 102) (:id . 60))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "VB") (:stem . "affect") (:form . "affect") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 139) (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 158)\n  (:start . 152) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "non-autonomous") (:form . "non-autonomous")\n  (:end . 178) (:start . 164) (:id . 71))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 185)\n  (:start . 179) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x5.209.1) (:span 108 114)))\n (:hscopes ((:id . :x5.209.1) (:span 108 185)))\n (:identifiers (:sid . :s5.209) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101620@unknown@formal@none@1@S@The lack of Cut expression in wild-type ventral cells abutting the D-V boundary indicates that D-mib is required for Ser signaling by dorsal cells and acts in a non-autonomous manner to activate N in ventral cells.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 26)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "abut") (:form . "abutting") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 94) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 100)\n  (:start . 95) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 112)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 120) (:start . 117)\n  (:id . 61))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 146)\n  (:start . 141) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 155) (:start . 151)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "non-autonomous") (:form . "non-autonomous")\n  (:end . 175) (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 182)\n  (:start . 176) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 194)\n  (:start . 186) (:id . 73))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 207)\n  (:start . 200) (:id . 76))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 213)\n  (:start . 208) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x5.211.1) (:span 80 94)))\n (:ncues ((:id . :x5.211.2) (:span 4 8)))\n (:hscopes ((:id . :x5.211.1) (:span 80 213)))\n (:nscopes ((:id . :x5.211.2) (:span 4 79)))\n (:identifiers (:sid . :s5.211) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101621@unknown@formal@none@1@S@Conversely, loss of D-mib activity in large ventral clones (Figure 6C and 6D) did not disrupt margin specification, indicating that D-mib is not strictly required for Dl signaling by ventral cells.@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "6c") (:form . "6C") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "6d") (:form . "6D") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 85) (:start . 82)\n  (:id . 59))\n ((:tag . "VB") (:stem . "disrupt") (:form . "disrupt") (:end . 93)\n  (:start . 86) (:id . 60))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 100)\n  (:start . 94) (:id . 61))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 114) (:start . 101) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 126)\n  (:start . 116) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 153)\n  (:start . 145) (:id . 69))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 162)\n  (:start . 154) (:id . 70))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 179)\n  (:start . 170) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 190)\n  (:start . 183) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 196)\n  (:start . 191) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x5.212.1) (:span 116 131)))\n (:ncues ((:id . :x5.212.2) (:span 82 85)))\n (:hscopes ((:id . :x5.212.1) (:span 116 196)))\n (:nscopes ((:id . :x5.212.2) (:span 82 114)))\n (:identifiers (:sid . :s5.212) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101622@unknown@formal@none@1@S@However, a narrowing of the Cut-positive margin was observed (Figure 6D), suggesting that D-mib contributes to regulating the level of Dl signaling.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 10) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "narrowing") (:form . "narrowing") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "cut-positive") (:form . "Cut-positive") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "NN") (:stem . "6d") (:form . "6D") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 84)\n  (:start . 74) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 107)\n  (:start . 96) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 121)\n  (:start . 111) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 131)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 137) (:start . 135)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 147)\n  (:start . 138) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x5.213.1) (:span 74 84)))\n (:hscopes ((:id . :x5.213.1) (:span 74 147)))\n (:identifiers (:sid . :s5.213) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101623@unknown@formal@none@1@S@Of note, ventral D-mib mutant cells expressed Cut, implying that D-mib is not required for N signal transduction.@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 22) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "express") (:form . "expressed") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "imply") (:form . "implying") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 92) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "transduction") (:form . "transduction") (:end . 112)\n  (:start . 100) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x5.214.2) (:span 51 59)))\n (:ncues ((:id . :x5.214.1) (:span 74 77)))\n (:hscopes ((:id . :x5.214.2) (:span 51 112)))\n (:nscopes ((:id . :x5.214.1) (:span 65 112)))\n (:identifiers (:sid . :s5.214) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101624@unknown@formal@none@1@S@We next tested whether expression of D-mib in dorsal cells is sufficient to rescue the D-mib wing phenotype.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "next") (:form . "next") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 72)\n  (:start . 62) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 92) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 97) (:start . 93)\n  (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x5.215.1) (:span 15 22)))\n (:hscopes ((:id . :x5.215.1) (:span 15 107)))\n (:identifiers (:sid . :s5.215) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101625@unknown@formal@none@1@S@D-mib was expressed in dorsal cells of D-mib2/D-mib3 mutant discs using Ser-GAL4.@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 52) (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ser-gal4") (:form . "Ser-GAL4") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.216) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101626@unknown@formal@none@1@S@Similarly to the expression of the Ser gene, Ser-GAL4 expression is restricted to dorsal cells in second/early third instar larvae and is weakly expressed in ventral cells in mid/late third instar larvae, i.e., after margin cell specification [49,50].@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ser-gal4") (:form . "Ser-GAL4") (:end . 53)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 78)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "second/early") (:form . "second/early") (:end . 110)\n  (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 116)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 130)\n  (:start . 124) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "RB") (:stem . "weakly") (:form . "weakly") (:end . 144)\n  (:start . 138) (:id . 65))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 154)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "ventral") (:form . "ventral") (:end . 165)\n  (:start . 158) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "mid/late") (:form . "mid/late") (:end . 183)\n  (:start . 175) (:id . 71))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 189)\n  (:start . 184) (:id . 72))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 196)\n  (:start . 190) (:id . 73))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 203)\n  (:start . 197) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 77))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 216)\n  (:start . 211) (:id . 78))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 223)\n  (:start . 217) (:id . 79))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 228) (:start . 224)\n  (:id . 80))\n ((:tag . "NN") (:stem . "specification") (:form . "specification")\n  (:end . 242) (:start . 229) (:id . 81))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 244) (:start . 243)\n  (:id . 82))\n ((:tag . "CD") (:stem . "49,50") (:form . "49,50") (:end . 249)\n  (:start . 244) (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 250) (:start . 249)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s5.217) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101627@unknown@formal@none@1@S@Expression of D-mib in dorsal cells was sufficient to rescue growth of the wing pouch and of the expression of Cut in margin cells in D-mib mutant discs (Figure 7A).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 79) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 107)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 124)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 130)\n  (:start . 125) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 139)\n  (:start . 134) (:id . 67))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 146)\n  (:start . 140) (:id . 68))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 152)\n  (:start . 147) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 154) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 163) (:start . 161)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s5.218) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101628@unknown@formal@none@1@S@This result confirmed that D-mib regulates Ser signaling by dorsal cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "confirm") (:form . "confirmed") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "ser") (:form . "Ser") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s5.219) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101630@unknown@formal@none@1@S@YFP::D-mib localized at the apical cortex and in the cytoplasm (Figure 7C–7 D???), as seen for endogenous D-mib (see Figure 3).@(((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cytoplasm") (:form . "cytoplasm") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NNP") (:stem . "7C–7") (:form . "7C–7") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 85) (:start . 83)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 90) (:start . 86)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 94) (:start . 91)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "endogenous") (:form . "endogenous") (:end . 105)\n  (:start . 95) (:id . 64))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 111)\n  (:start . 106) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 66))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 116) (:start . 113)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 123)\n  (:start . 117) (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 125) (:start . 124)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.221) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101631@unknown@formal@none@1@S@YFP::D-mib co-localized with Dl and Ser at the apical cortex of cells expressing low levels of YFP::D-mib.@(((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "co-localized") (:form . "co-localized") (:end . 23)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 105)\n  (:start . 95) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.222) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101632@unknown@formal@none@1@S@However, cells expressing high levels of YFP::D-mib showed a strong reduction in the level of both Dl and Ser at the cortex (Figure 7C–7C???)''', further indicating that D-mib down-regulates the levels of both Ser and Dl at the apical cortex (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . 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5101633@unknown@formal@none@1@S@Expression of D-mib in Dorsal Cells Is Sufficient to Rescue the D-mib Mutant Phenotype@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Dorsal") (:form . "Dorsal") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NNP") (:stem . "Cells") (:form . "Cells") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "Sufficient") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "rescue") (:form . "Rescue") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Mutant") (:form . "Mutant") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 86)\n  (:start . 77) (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.224) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101634@unknown@formal@none@1@S@(A) Expression of D-mib (green) in dorsal cells, using Ser-GAL4, rescued the growth of the wing pouch and margin Cut (red) expression in D-mib2/D-mib3 mutant discs.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "NN") (:stem . "green") (:form . "green") (:end . 30) (:start . 25)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 41)\n  (:start . 35) (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 47) (:start . 42)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 54) (:start . 49)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ser-gal4") (:form . "Ser-GAL4") (:end . 63)\n  (:start . 55) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 72)\n  (:start . 65) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 59))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 83)\n  (:start . 77) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 62))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 95) (:start . 91)\n  (:id . 63))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 101) (:start . 96)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 65))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 112)\n  (:start . 106) (:id . 66))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 116) (:start . 113)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 121) (:start . 118)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 133)\n  (:start . 123) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 72))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 150) (:start . 137) (:id . 73))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 157)\n  (:start . 151) (:id . 74))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 163)\n  (:start . 158) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s5.225) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101635@unknown@formal@none@1@S@(B–D???) Ser-GAL4-driven expression of YFP::D-mib (green) rescued the D-mib2/D-mib3 phenotype and strongly reduced the level of Dl (blue in [B, B?, C, C??, D, and D??]) and Ser (red in [B, B??, C, C???, D, and D???]) in dorsal cells.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "b–d") (:form . "B–D") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 8) (:start . 7) (:id . 47))\n ((:tag . "JJ") (:stem . "ser-gal4-driven") (:form . "Ser-GAL4-driven")\n  (:end . 24) (:start . 9) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 35)\n  (:start . 25) (:id . 49))\n ((:tag . "IN") (:stem . 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5101636@unknown@formal@none@1@S@(C–D???) are high-magnification views (apical [C–C???] and basal [D–D???]) of the disc shown in (B–B??).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "VBN") (:stem . "c–d") (:form . "C–D") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 7) (:start . 6) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 8) (:start . 7) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 12) (:start . 9)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "high-magnification") (:form . "high-magnification")\n  (:end . 31) (:start . 13) (:id . 49))\n ((:tag . "NNS") (:stem . "view") (:form . "views") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 45)\n  (:start . 39) (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 47) (:start . 46)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C–C") (:form . "C–C") (:end . 50) (:start . 47)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 51) (:start . 50)\n  (:id . 55))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 52) (:start . 51)\n  (:id . 56))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 53) (:start . 52)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 54) (:start . 53)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "basal") (:form . "basal") (:end . 64) (:start . 59)\n  (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 66) (:start . 65)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D–D") (:form . "D–D") (:end . 69) (:start . 66)\n  (:id . 62))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 70) (:start . 69)\n  (:id . 63))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 71) (:start . 70)\n  (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 72) (:start . 71)\n  (:id . 65))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 73) (:start . 72)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 69))\n ((:tag . "NN") (:stem . "disc") (:form . "disc") (:end . 86) (:start . 82)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 92) (:start . 87)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 97) (:start . 96)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "B–B") (:form . "B–B") (:end . 100) (:start . 97)\n  (:id . 74))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 101) (:start . 100)\n  (:id . 75))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 102) (:start . 101)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 103) (:start . 102)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s5.227) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101637@unknown@formal@none@1@S@YFP::D-mib co-localized with Dl and Ser at the apical cortex in cells expressing only low levels of YFP::D-mib.@(((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "co-localized") (:form . "co-localized") (:end . 23)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 28) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 69) (:start . 64)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 80)\n  (:start . 70) (:id . 54))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 85) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "YFP::D-mib") (:form . "YFP::D-mib") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.228) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101638@unknown@formal@none@1@S@Bar is 50 ?m for (A–B??) and 10 ?m for (C–D???).@(((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A–B") (:form . "A–B") (:end . 21) (:start . 18)\n  (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 22) (:start . 21)\n  (:id . 49))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 23) (:start . 22)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 31) (:start . 29)\n  (:id . 53))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 34) (:start . 32)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 38) (:start . 35)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 40) (:start . 39)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "C–D") (:form . "C–D") (:end . 43) (:start . 40)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 44) (:start . 43)\n  (:id . 58))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 45) (:start . 44)\n  (:id . 59))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 46) (:start . 45)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s5.229) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101640@unknown@formal@none@1@S@The functional assay was then used to genetically position the requirement for the D-mib gene activity relative to Ser and N (Figure 8).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 49)\n  (:start . 38) (:id . 49))\n ((:tag . "VB") (:stem . "position") (:form . "position") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "requirement") (:form . "requirement") (:end . 74)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 111)\n  (:start . 103) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 132)\n  (:start . 126) (:id . 64))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 134) (:start . 133)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s5.231) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101641@unknown@formal@none@1@S@Expression of an activated version of N, Ncdc10 [51], led to the activation of Cut and promoted growth in dorsal cells of D-mib2/D-mib3 mutant discs (Figure 8C).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ncdc10") (:form . "Ncdc10") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "CD") (:stem . "51") (:form . "51") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 52) (:start . 51)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 57) (:start . 54)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 57))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 75)\n  (:start . 65) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 82) (:start . 79)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "promote") (:form . "promoted") (:end . 95)\n  (:start . 87) (:id . 62))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 102)\n  (:start . 96) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 112)\n  (:start . 106) (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 67))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 135) (:start . 122) (:id . 68))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 142)\n  (:start . 136) (:id . 69))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 148)\n  (:start . 143) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 156)\n  (:start . 150) (:id . 72))\n ((:tag . "NN") (:stem . "8c") (:form . "8C") (:end . 159) (:start . 157)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s5.232) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101642@unknown@formal@none@1@S@This indicates that D-mib acts at a step upstream of N activation.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 49)\n  (:start . 41) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x5.233.1) (:span 5 19)))\n (:hscopes ((:id . :x5.233.1) (:span 5 65)))\n (:identifiers (:sid . :s5.233) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101643@unknown@formal@none@1@S@By contrast, elevated levels of Ser expression failed to restore Cut expression and growth of the wing pouch in D-mib2/D-mib3 mutant larvae (Figure 8B).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 53) (:start . 47)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "restore") (:form . "restore") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "cut") (:form . "Cut") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 79)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 90)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 125) (:start . 112) (:id . 62))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "8b") (:form . "8B") (:end . 150) (:start . 148)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x5.234.1) (:span 47 53)))\n (:nscopes ((:id . :x5.234.1) (:span 47 139)))\n (:identifiers (:sid . :s5.234) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101644@unknown@formal@none@1@S@This confirms that Ser signaling requires the activity of the D-mib gene, i.e., that D-mib acts downstream of Ser.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "confirm") (:form . "confirms") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 78) (:start . 74)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 106)\n  (:start . 96) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s5.235) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101645@unknown@formal@none@1@S@Expression of Neur in Dorsal Cells Is Sufficient to Rescue the D-mib Mutant Phenotype@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Dorsal") (:form . "Dorsal") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "Cells") (:form . "Cells") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "Sufficient") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "VB") (:stem . "rescue") (:form . "Rescue") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Mutant") (:form . "Mutant") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 85)\n  (:start . 76) (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.236) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101646@unknown@formal@none@1@S@D-mib2/D-mib3 mutant discs expressing GFP (A) (GFP staining not shown), Ser (B), Ncdc10 (C), or Neur (D) under the control of Ser-GAL4 were stained for Cut (red).@(((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 20)\n  (:start . 14) (:id . 43))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 26) (:start . 21)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 37)\n  (:start . 27) (:id . 45))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "staining") (:form . "staining") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 78) (:start . 77)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ncdc10") (:form . "Ncdc10") (:end . 87)\n  (:start . 81) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 90) (:start . 89)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 95) (:start . 93)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 100) (:start . 96)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 103) (:start . 102)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 71))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 110)\n  (:start . 105) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 73))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 122)\n  (:start . 115) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 125) (:start . 123)\n  (:id . 75))\n ((:tag . "NN") (:stem . "ser-gal4") (:form . "Ser-GAL4") (:end . 134)\n  (:start . 126) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 139) (:start . 135)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 147)\n  (:start . 140) (:id . 78))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 151) (:start . 148)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 155) (:start . 152)\n  (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 157) (:start . 156)\n  (:id . 81))\n ((:tag . "NN") (:stem . "red") (:form . "red") (:end . 160) (:start . 157)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x5.237.1) (:span 60 63)))\n (:nscopes ((:id . :x5.237.1) (:span 60 70)))\n (:identifiers (:sid . :s5.237) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101647@unknown@formal@none@1@S@Expression of Ser in dorsal cells did not rescue the D-mib2/D-mib3 wing pouch mutant phenotype (compare [B] with [A]), consistent with D-mib being required for Ser signaling.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 66) (:start . 53) (:id . 52))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "compare") (:form . "compare") (:end . 103)\n  (:start . 96) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 112) (:start . 108)\n  (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 116) (:start . 115)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 117) (:start . 116)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 129)\n  (:start . 119) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 134) (:start . 130)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 140)\n  (:start . 135) (:id . 70))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 146) (:start . 141)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 155)\n  (:start . 147) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 159) (:start . 156)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 163) (:start . 160)\n  (:id . 74))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 173)\n  (:start . 164) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x5.238.1) (:span 38 41)))\n (:nscopes ((:id . :x5.238.1) (:span 38 94)))\n (:identifiers (:sid . :s5.238) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101648@unknown@formal@none@1@S@By contrast, expression of Ncdc10, an activated version of N, led to the deregulated growth of the dorsal compartment and the expression of Cut in most dorsal cells (C), indicating that activated N acts downstream of D-mib.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Ncdc10") (:form . "Ncdc10") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "lead") (:form . "led") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 68) (:start . 66)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "deregulate") (:form . "deregulated") (:end . 84)\n  (:start . 73) (:id . 58))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 91)\n  (:start . 85) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 105)\n  (:start . 99) (:id . 62))\n ((:tag . "NN") (:stem . "compartment") (:form . "compartment") (:end . 117)\n  (:start . 106) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 136)\n  (:start . 126) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 143) (:start . 140)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 151) (:start . 147)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 158)\n  (:start . 152) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 164)\n  (:start . 159) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 167) (:start . 166)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 168) (:start . 167)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 180)\n  (:start . 170) (:id . 77))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 185) (:start . 181)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 195)\n  (:start . 186) (:id . 79))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 197) (:start . 196)\n  (:id . 80))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 202) (:start . 198)\n  (:id . 81))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 213)\n  (:start . 203) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 222)\n  (:start . 217) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 223) (:start . 222)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x5.239.1) (:span 170 185)))\n (:hscopes ((:id . :x5.239.1) (:span 170 222)))\n (:identifiers (:sid . :s5.239) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101650@unknown@formal@none@1@S@Bar is 40 ?m for all panels.@(((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "panel") (:form . "panels") (:end . 27)\n  (:start . 21) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 28) (:start . 27)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s5.241) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101651@unknown@formal@none@1@S@neur and D-mib Functions Partially Overlap@(((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNPS") (:stem . "Functions") (:form . "Functions") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "Partially") (:form . "Partially") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "Overlap") (:form . "Overlap") (:end . 42)\n  (:start . 35) (:id . 47)))@@@1@6@((:identifiers (:sid . :s5.242) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101652@unknown@formal@none@1@S@The different requirements for neur and D-mib gene activity may suggest that Neur and D-mib have distinct molecular activities.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "requirement") (:form . "requirements") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 126)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x5.243.1) (:span 64 71)) ((:id . :x5.243.2) (:span 60 63)))\n (:hscopes ((:id . :x5.243.1) (:span 64 126))\n  ((:id . :x5.243.2) (:span 60 126)))\n (:identifiers (:sid . :s5.243) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101653@unknown@formal@none@1@S@Alternatively, this difference may reflect a difference in gene expression.@(((:tag . "RB") (:stem . "alternatively") (:form . "Alternatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 30)\n  (:start . 20) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 63) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:hcues ((:id . :x5.244.1) (:span 31 34)))\n (:hscopes ((:id . :x5.244.1) (:span 31 74)))\n (:identifiers (:sid . :s5.244) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101654@unknown@formal@none@1@S@Consistent with the latter hypothesis, the neur gene is not expressed in wing pouch and wing margin cells, where it is not required, and appears to be expressed only in sensory cells [52], where it is required.@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 105)\n  (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 115) (:start . 113)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 118) (:start . 116)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 122) (:start . 119)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 131)\n  (:start . 123) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 144)\n  (:start . 137) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 150) (:start . 148)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 160)\n  (:start . 151) (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 165) (:start . 161)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 168) (:start . 166)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 176)\n  (:start . 169) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 182)\n  (:start . 177) (:id . 76))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 184) (:start . 183)\n  (:id . 77))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 186) (:start . 184)\n  (:id . 78))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 187) (:start . 186)\n  (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 80))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 194)\n  (:start . 189) (:id . 81))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 197) (:start . 195)\n  (:id . 82))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 200) (:start . 198)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 209)\n  (:start . 201) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x5.245.1) (:span 137 144)))\n (:ncues ((:id . :x5.245.2) (:span 119 122))\n  ((:id . :x5.245.3) (:span 56 59)))\n (:hscopes ((:id . :x5.245.1) (:span 137 209)))\n (:nscopes ((:id . :x5.245.2) (:span 113 131))\n  ((:id . :x5.245.3) (:span 39 131)))\n (:identifiers (:sid . :s5.245) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101655@unknown@formal@none@1@S@By contrast, D-mib appears to be uniformly expressed in imaginal discs.@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "uniformly") (:form . "uniformly") (:end . 42)\n  (:start . 33) (:id . 49))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x5.246.1) (:span 19 26)))\n (:hscopes ((:id . :x5.246.1) (:span 13 70)))\n (:identifiers (:sid . :s5.246) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101656@unknown@formal@none@1@S@To test this hypothesis, we examined whether the forced ubiquitous expression of the neur gene can suppress the D-mib loss-of-function phenotype.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "examine") (:form . "examined") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "forced") (:form . "forced") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "VB") (:stem . "suppress") (:form . "suppress") (:end . 107)\n  (:start . 99) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "JJ") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 134) (:start . 118) (:id . 62))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 144)\n  (:start . 135) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x5.247.1) (:span 37 44)))\n (:hscopes ((:id . :x5.247.1) (:span 37 144)))\n (:identifiers (:sid . :s5.247) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101657@unknown@formal@none@1@S@Expression of Neur, using actin-GAL4, restored growth of the wing pouch and formation of the wing margin (data not shown).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "actin-gal4") (:form . "actin-GAL4") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "restore") (:form . "restored") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 110)\n  (:start . 106) (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x5.248.1) (:span 111 114)))\n (:nscopes ((:id . :x5.248.1) (:span 105 121)))\n (:identifiers (:sid . :s5.248) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101658@unknown@formal@none@1@S@Moreover, expression of Neur in dorsal cells, using Ser-GAL4, was sufficient to rescue growth of the wing pouch as well as the expression of Cut in margin cells in D-mib mutant discs (Figure 8D).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ser-gal4") (:form . "Ser-GAL4") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 76)\n  (:start . 66) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 86)\n  (:start . 80) (:id . 57))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 114) (:start . 112)\n  (:id . 63))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 137)\n  (:start . 127) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 144) (:start . 141)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 70))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 154)\n  (:start . 148) (:id . 71))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 160)\n  (:start . 155) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 169)\n  (:start . 164) (:id . 74))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 176)\n  (:start . 170) (:id . 75))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 182)\n  (:start . 177) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 190)\n  (:start . 184) (:id . 78))\n ((:tag . "NN") (:stem . "8d") (:form . "8D") (:end . 193) (:start . 191)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 194) (:start . 193)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s5.249) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101660@unknown@formal@none@1@S@In a converse experiment, we found that the neur-driven expression of D-mib, using neurPGAL4, did not rescue the cuticular neurogenic phenotype of neurPGAL4/neur1F65 embryos.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "converse") (:form . "converse") (:end . 13)\n  (:start . 5) (:id . 44))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "neur-driven") (:form . "neur-driven") (:end . 55)\n  (:start . 44) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 66)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "neurpgal4") (:form . "neurPGAL4") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 108)\n  (:start . 102) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "cuticular") (:form . "cuticular") (:end . 122)\n  (:start . 113) (:id . 63))\n ((:tag . "JJ") (:stem . "neurogenic") (:form . "neurogenic") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 143)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "neurpgal4/neur1f65") (:form . "neurPGAL4/neur1F65")\n  (:end . 165) (:start . 147) (:id . 67))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 173)\n  (:start . 166) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x5.251.1) (:span 98 101)))\n (:nscopes ((:id . :x5.251.1) (:span 98 173)))\n (:identifiers (:sid . :s5.251) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101661@unknown@formal@none@1@S@Three UAS-D-mib transgenic lines were tested, and none showed detectable rescue whereas the two UAS-neur lines used as positive controls either fully or partially rescued the cuticular neurogenic phenotype of neurPGAL4/neur1F65 embryos (data not shown; UAS-D-mib+/+, neurPGAL4+/+ embryos developed normally).@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "uas-d-mib") (:form . "UAS-D-mib") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 32) (:start . 27)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 44) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 61) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "detectable") (:form . "detectable") (:end . 72)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "UAS-neur") (:form . "UAS-neur") (:end . 104)\n  (:start . 96) (:id . 57))\n ((:tag . "NNS") (:stem . "line") (:form . 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"the") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "cuticular") (:form . "cuticular") (:end . 184)\n  (:start . 175) (:id . 69))\n ((:tag . "JJ") (:stem . "neurogenic") (:form . "neurogenic") (:end . 195)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 205)\n  (:start . 196) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 208) (:start . 206)\n  (:id . 72))\n ((:tag . "NN") (:stem . "neurpgal4/neur1f65") (:form . "neurPGAL4/neur1F65")\n  (:end . 227) (:start . 209) (:id . 73))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 235)\n  (:start . 228) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 237) (:start . 236)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 241)\n  (:start . 237) (:id . 76))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 245) (:start . 242)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 251)\n  (:start . 246) (:id . 78))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 252) (:start . 251)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "uas-d-mib+/+") (:form . "UAS-D-mib+/+") (:end . 265)\n  (:start . 253) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 266) (:start . 265)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "neurpgal4+/+") (:form . "neurPGAL4+/+") (:end . 279)\n  (:start . 267) (:id . 82))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 287)\n  (:start . 280) (:id . 83))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 297)\n  (:start . 288) (:id . 84))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 306)\n  (:start . 298) (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 307) (:start . 306)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 308) (:start . 307)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x5.252.2) (:span 137 143 150 152)))\n (:ncues ((:id . :x5.252.1) (:span 242 245))\n  ((:id . :x5.252.4) (:span 50 54)))\n (:hscopes ((:id . :x5.252.2) (:span 137 162)))\n (:nscopes ((:id . :x5.252.1) (:span 236 251))\n  ((:id . :x5.252.4) (:span 50 79)))\n (:identifiers (:sid . :s5.252) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101662@unknown@formal@none@1@S@This indicates that a key function of Neur in the embryo cannot be provided by D-mib.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "embryo") (:form . "embryo") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 75)\n  (:start . 67) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 85) (:start . 84)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x5.253.2) (:span 5 19)))\n (:ncues ((:id . :x5.253.1) (:span 57 63)))\n (:hscopes ((:id . :x5.253.2) (:span 5 84)))\n (:nscopes ((:id . :x5.253.1) (:span 20 84)))\n (:identifiers (:sid . :s5.253) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101663@unknown@formal@none@1@S@We therefore suggest that Neur and D-mib functions overlap but are not strictly identical.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "VBP") (:stem . "overlap") (:form . "overlap") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x5.254.1) (:span 13 20)))\n (:hscopes ((:id . :x5.254.1) (:span 13 89)))\n (:identifiers (:sid . :s5.254) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101664@unknown@formal@none@1@S@Discussion@(((:tag . "NN") (:stem . "discussion") (:form . "Discussion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s5.255) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101665@unknown@formal@none@1@S@Many recent studies have revealed that endocytosis plays multiple roles in the regulation of N signaling (reviewed in [2]; see also [53,54]).@(((:tag . "JJ") (:stem . "many") (:form . "Many") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "reveal") (:form . "revealed") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "role") (:form . "roles") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 89)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 131) (:start . 127)\n  (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "CD") (:stem . "53,54") (:form . "53,54") (:end . 138)\n  (:start . 133) (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 139) (:start . 138)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s5.256) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101666@unknown@formal@none@1@S@Here, we show that the conserved E3 ubiquitin ligases Neur and D-mib have similar molecular activities in the regulation of Dl and Ser endocytosis but distinct developmental functions in Drosophila.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 13) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 32)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 45)\n  (:start . 36) (:id . 50))\n ((:tag . "NNS") (:stem . "ligas") (:form . "ligases") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 91)\n  (:start . 82) (:id . 57))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 146)\n  (:start . 135) (:id . 66))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 173) (:start . 160) (:id . 69))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 183)\n  (:start . 174) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 197)\n  (:start . 187) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s5.257) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101667@unknown@formal@none@1@S@Our analysis first establishes that D-mib regulates Ser signaling during wing development.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "establish") (:form . "establishes") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "ser") (:form . "Ser") (:end . 55) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 65)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 89)\n  (:start . 78) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.258) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101668@unknown@formal@none@1@S@First, clonal analysis revealed that the activity of the D-mib gene is specifically required in dorsal cells for the expression of Cut at the wing margin.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "clonal") (:form . "clonal") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 83)\n  (:start . 71) (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 127)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Cut") (:form . "Cut") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 137) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 153)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 154) (:start . 153)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s5.259) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101670@unknown@formal@none@1@S@Third, results from an in vivo antibody uptake assay indicated that the endocytosis of Ser (but not of Dl) was strongly inhibited in D-mib mutant cells.@(((:tag . "RB") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 30) (:start . 26)\n  (:id . 48))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "uptake") (:form . "uptake") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 62)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 64))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 119)\n  (:start . 111) (:id . 65))\n ((:tag . "VBN") (:stem . "inhibit") (:form . "inhibited") (:end . 129)\n  (:start . 120) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 138)\n  (:start . 133) (:id . 68))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 145)\n  (:start . 139) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x5.261.2) (:span 53 67)))\n (:ncues ((:id . :x5.261.1) (:span 96 99)))\n (:hscopes ((:id . :x5.261.2) (:span 53 151)))\n (:nscopes ((:id . :x5.261.1) (:span 96 106)))\n (:identifiers (:sid . :s5.261) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101671@unknown@formal@none@1@S@This inhibition correlated with the strong accumulation of Ser (but not Dl) at the apical cortex of D-mib mutant cells.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "correlate") (:form . "correlated") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 89)\n  (:start . 83) (:id . 58))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 96)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 112)\n  (:start . 106) (:id . 62))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 118)\n  (:start . 113) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x5.262.1) (:span 68 71)))\n (:nscopes ((:id . :x5.262.1) (:span 68 75)))\n (:identifiers (:sid . :s5.262) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101672@unknown@formal@none@1@S@Thus, an essential function of D-mib in the wing is to regulate the endocytosis of Ser in dorsal cells to non-autonomously promote the activation of N along the D-V boundary.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 18)\n  (:start . 9) (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 63)\n  (:start . 55) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 79)\n  (:start . 68) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 96)\n  (:start . 90) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 102) (:start . 97)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "RB") (:stem . "non-autonomously") (:form . "non-autonomously")\n  (:end . 122) (:start . 106) (:id . 63))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 173)\n  (:start . 165) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s5.263) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101673@unknown@formal@none@1@S@By analogy, the defective growth of the eye tissue may similarly result from the lack of Ser signaling and of N activation along the D-V boundary [55].@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analogy") (:form . "analogy") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 32)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "eye") (:form . "eye") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 50)\n  (:start . 44) (:id . 51))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 64)\n  (:start . 55) (:id . 53))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 102)\n  (:start . 93) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 122)\n  (:start . 112) (:id . 64))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 128)\n  (:start . 123) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D-V") (:form . "D-V") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "boundary") (:form . "boundary") (:end . 145)\n  (:start . 137) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 147) (:start . 146)\n  (:id . 69))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 149) (:start . 147)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 150) (:start . 149)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x5.264.2) (:span 51 54)))\n (:ncues ((:id . :x5.264.1) (:span 81 85)))\n (:hscopes ((:id . :x5.264.2) (:span 51 145)))\n (:nscopes ((:id . :x5.264.1) (:span 81 145)))\n (:identifiers (:sid . :s5.264) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101674@unknown@formal@none@1@S@Because D-mib co-localizes with Ser at the apical cortex of wing disc cells, acts in a RING-finger-dependent manner to regulate Ser endocytosis in S2 cells (R. L. B. and F. S., unpublished results), and physically associates with Ser in co-immunoprecipitation experiments (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data), D-mib may ubiquitinate Ser and directly regulate its endocytosis.@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "co-localize") (:form . "co-localizes") (:end . 26)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . 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"regulate") (:end . 410)\n  (:start . 402) (:id . 119))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 414) (:start . 411)\n  (:id . 120))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 426)\n  (:start . 415) (:id . 121))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 427) (:start . 426)\n  (:id . 122)))@@@1@81@((:hcues ((:id . :x5.265.1) (:span 368 371)))\n (:hscopes ((:id . :x5.265.1) (:span 368 426)))\n (:identifiers (:sid . :s5.265) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101675@unknown@formal@none@1@S@Our analysis further suggests that endocytosis of Ser is required for Ser signaling.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 65)\n  (:start . 57) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x5.266.1) (:span 21 29)))\n (:hscopes ((:id . :x5.266.1) (:span 21 83)))\n (:identifiers (:sid . :s5.266) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101676@unknown@formal@none@1@S@This conclusion is consistent with observations made earlier showing that secreted versions of Ser cannot activate N but instead antagonize Ser signaling [56,57].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 47)\n  (:start . 35) (:id . 47))\n ((:tag . "VBN") (:stem . "make") (:form . "made") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 82)\n  (:start . 74) (:id . 52))\n ((:tag . "NNS") (:stem . "version") (:form . "versions") (:end . 91)\n  (:start . 83) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 105)\n  (:start . 99) (:id . 56))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 114)\n  (:start . 106) (:id . 57))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "VB") (:stem . "antagonize") (:form . "antagonize") (:end . 139)\n  (:start . 129) (:id . 61))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . "CD") (:stem . "56,57") (:form . "56,57") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x5.267.1) (:span 99 105)))\n (:nscopes ((:id . :x5.267.1) (:span 99 116)))\n (:identifiers (:sid . :s5.267) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101677@unknown@formal@none@1@S@Thus, endocytosis of both N ligands appears to be strictly required for N activation in Drosophila.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "RB") (:stem . "strictly") (:form . "strictly") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 84)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x5.268.1) (:span 36 43)))\n (:hscopes ((:id . :x5.268.1) (:span 6 98)))\n (:identifiers (:sid . :s5.268) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101678@unknown@formal@none@1@S@Different models have been proposed to explain how endocytosis of the ligand, which removes the ligand from the cell surface, results in N receptor activation (discussed in [17,20,21,30]).@(((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 62)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "remove") (:form . "removes") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ligand") (:form . "ligand") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 107) (:start . 103)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 158)\n  (:start . 148) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 169)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "CD") (:stem . "17,20,21,30") (:form . "17,20,21,30") (:end . 185)\n  (:start . 174) (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s5.269) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101680@unknown@formal@none@1@S@Noticeably, there is no C. elegans Mib homolog, and the function of C. elegans neur (F10D7.5) is not known.@(((:tag . "RB") (:stem . "noticeably") (:form . "Noticeably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 64)\n  (:start . 56) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 78)\n  (:start . 71) (:id . 57))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "NN") (:stem . "f10d7.5") (:form . "F10D7.5") (:end . 92)\n  (:start . 85) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 100) (:start . 97)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 106)\n  (:start . 101) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x5.271.1) (:span 97 106)))\n (:ncues ((:id . :x5.271.2) (:span 21 23)))\n (:hscopes ((:id . :x5.271.1) (:span 52 106)))\n (:nscopes ((:id . :x5.271.2) (:span 21 46)))\n (:identifiers (:sid . :s5.271) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101681@unknown@formal@none@1@S@We speculate that endocytosis of the ligands may have evolved as a means to ensure tight spatial regulation of the activation of N.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "speculate") (:form . "speculate") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "ligand") (:form . "ligands") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "means") (:form . "means") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 82)\n  (:start . 76) (:id . 56))\n ((:tag . "JJ") (:stem . "tight") (:form . "tight") (:end . 88) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "spatial") (:form . "spatial") (:end . 96)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x5.272.1) (:span 45 48)) ((:id . :x5.272.2) (:span 3 12)))\n (:hscopes ((:id . :x5.272.1) (:span 45 130))\n  ((:id . :x5.272.2) (:span 3 130)))\n (:identifiers (:sid . :s5.272) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101682@unknown@formal@none@1@S@Our analysis also establishes that the activity of the D-mib gene is required for a subset of N signaling events that are distinct from those that require the activity of the neur gene.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "establish") (:form . "establishes") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "subset") (:form . "subset") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "N") (:form . "N") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 105)\n  (:start . 96) (:id . 60))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 154)\n  (:start . 147) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 167)\n  (:start . 159) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 179) (:start . 175)\n  (:id . 73))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 184) (:start . 180)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s5.273) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101683@unknown@formal@none@1@S@We have shown that the D-mib gene regulates wing margin formation, leg segmentation, and vein formation, whereas none of these three processes depend on neur gene activity ([45,60]; this study).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "VBG") (:stem . "wing") (:form . "wing") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "margin") (:form . "margin") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 65)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "leg") (:form . "leg") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "segmentation") (:form . "segmentation") (:end . 83)\n  (:start . 71) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "NN") (:stem . "vein") (:form . "vein") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 103)\n  (:start . 94) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 126)\n  (:start . 121) (:id . 64))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 132)\n  (:start . 127) (:id . 65))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "VBP") (:stem . "depend") (:form . "depend") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 157) (:start . 153)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 162) (:start . 158)\n  (:id . 70))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 171)\n  (:start . 163) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . "CD") (:stem . "45,60") (:form . "45,60") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 180) (:start . 179)\n  (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 181) (:start . 180)\n  (:id . 76))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 186) (:start . 182)\n  (:id . 77))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 192)\n  (:start . 187) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 193) (:start . 192)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 194) (:start . 193)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x5.274.1) (:span 113 117)))\n (:nscopes ((:id . :x5.274.1) (:span 113 171)))\n (:identifiers (:sid . :s5.274) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101684@unknown@formal@none@1@S@Conversely, the activity of the neur gene is essential for binary cell-fate decisions in the bristle lineage [22] that do not require the activity of the D-mib gene (no bristle defects were seen in D-mib mutant flies).@(((:tag . "RB") (:stem . "conversely") (:form . "Conversely") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "binary") (:form . "binary") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "JJ") (:stem . "cell-fate") (:form . "cell-fate") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "NNS") (:stem . "decision") (:form . "decisions") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bristle") (:form . "bristle") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 133)\n  (:start . 126) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 159)\n  (:start . 154) (:id . 71))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 168) (:start . 166)\n  (:id . 74))\n ((:tag . "NN") (:stem . "bristle") (:form . "bristle") (:end . 176)\n  (:start . 169) (:id . 75))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 184)\n  (:start . 177) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 189) (:start . 185)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 194) (:start . 190)\n  (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 203)\n  (:start . 198) (:id . 80))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 210)\n  (:start . 204) (:id . 81))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 216) (:start . 211)\n  (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 217) (:start . 216)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 84)))@@@1@43@((:ncues ((:id . :x5.275.1) (:span 165 168))\n  ((:id . :x5.275.2) (:span 122 125)))\n (:nscopes ((:id . :x5.275.1) (:span 165 217))\n  ((:id . :x5.275.2) (:span 122 164)))\n (:identifiers (:sid . :s5.275) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101685@unknown@formal@none@1@S@The activity of the neur gene is also required for lateral inhibition during neurogenesis in embryos and pupae [4,45,61].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 46)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "lateral") (:form . "lateral") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 76)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "neurogenesis") (:form . "neurogenesis") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "embryo") (:form . "embryos") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "VB") (:stem . "pupae") (:form . "pupae") (:end . 110)\n  (:start . 105) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CD") (:stem . "4,45,61") (:form . "4,45,61") (:end . 119)\n  (:start . 112) (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s5.276) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101686@unknown@formal@none@1@S@This process is largely independent of D-mib gene activity since the complete loss of D-mib function only resulted in a mild neurogenic phenotype in the notum.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "mild") (:form . "mild") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "neurogenic") (:form . "neurogenic") (:end . 135)\n  (:start . 125) (:id . 63))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 145)\n  (:start . 136) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "notum") (:form . "notum") (:end . 158)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s5.277) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101687@unknown@formal@none@1@S@These data thus indicate that the neur and D-mib genes have largely distinct and complementary functions in Drosophila.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "complementary") (:form . "complementary")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 104)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 118)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x5.278.1) (:span 16 29)))\n (:hscopes ((:id . :x5.278.1) (:span 16 118)))\n (:identifiers (:sid . :s5.278) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101688@unknown@formal@none@1@S@Whether a similar functional relationship between Neur and D-mib exists in vertebrates awaits the study of the D. rerio neur genes and/or of the murine Mib and Neur genes.@(((:tag . "IN") (:stem . "whether") (:form . "Whether") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 41)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 54) (:start . 50)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 64) (:start . 59)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 86)\n  (:start . 75) (:id . 53))\n ((:tag . "VBZ") (:stem . "await") (:form . "awaits") (:end . 93)\n  (:start . 87) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 103) (:start . 98)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rerio") (:form . "rerio") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 137)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "NNP") (:stem . "Mib") (:form . "Mib") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 170)\n  (:start . 165) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x5.279.1) (:span 0 7)))\n (:hscopes ((:id . :x5.279.1) (:span 0 86)))\n (:identifiers (:sid . :s5.279) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101690@unknown@formal@none@1@S@First, both Neur and D-mib physically interact with Dl ([20]; E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data) and promote the down-regulation of Dl from the apical membrane when overexpressed (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data).@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "RB") (:stem . "physically") (:form . 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5101691@unknown@formal@none@1@S@Furthermore, Dl signaling appears to require the activity of either Neur or D-mib, depending on the developmental contexts.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 81) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 92)\n  (:start . 83) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 113) (:start . 100) (:id . 60))\n ((:tag . "NNS") (:stem . "context") (:form . "contexts") (:end . 122)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x5.282.1) (:span 26 33)))\n (:hscopes ((:id . :x5.282.1) (:span 13 122)))\n (:identifiers (:sid . :s5.282) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101692@unknown@formal@none@1@S@We have shown here that specific aspects of the D-mib phenotype in legs and in the notum cannot simply result from loss of Ser signaling and are consistent with reduced Dl signaling, suggesting that D-mib regulates Dl signaling.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "d-mib") (:form . "D-mib") (:end . 53) (:start . 48)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "leg") (:form . "legs") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "notum") (:form . "notum") (:end . 88) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "VB") (:stem . "result") (:form . "result") (:end . 109)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 62))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 136)\n  (:start . 127) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 155)\n  (:start . 145) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 168)\n  (:start . 161) (:id . 71))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 181)\n  (:start . 172) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 193)\n  (:start . 183) (:id . 75))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 198) (:start . 194)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 204)\n  (:start . 199) (:id . 77))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 214)\n  (:start . 205) (:id . 78))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 217) (:start . 215)\n  (:id . 79))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 227)\n  (:start . 218) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x5.283.1) (:span 183 193))\n  ((:id . :x5.283.2) (:span 145 160)))\n (:ncues ((:id . :x5.283.3) (:span 89 95)))\n (:hscopes ((:id . :x5.283.1) (:span 183 227))\n  ((:id . :x5.283.2) (:span 145 181)))\n (:nscopes ((:id . :x5.283.3) (:span 89 136)))\n (:identifiers (:sid . :s5.283) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101693@unknown@formal@none@1@S@Consistent with this interpretation, overexpression studies indicate that D-mib up-regulates the signaling activity of Dl, whereas a dominant-negative form of D-mib inhibits it (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data).@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 35) (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 51) (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "study") (:form . 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5101694@unknown@formal@none@1@S@We note, however, that no clear defects in Dl subcellular localization and/or trafficking were observed in D-mib mutant cells.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "note") (:form . "note") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 16)\n  (:start . 9) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 25) (:start . 23)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 31) (:start . 26)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 39)\n  (:start . 32) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "subcellular") (:form . "subcellular") (:end . 57)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 70)\n  (:start . 58) (:id . 54))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "trafficking") (:form . "trafficking") (:end . 89)\n  (:start . 78) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 94) (:start . 90)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 103)\n  (:start . 95) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 112)\n  (:start . 107) (:id . 60))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x5.285.1) (:span 23 25)))\n (:nscopes ((:id . :x5.285.1) (:span 23 125)))\n (:identifiers (:sid . :s5.285) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101695@unknown@formal@none@1@S@It is conceivable that the contribution of D-mib to the endocytosis of Dl is masked by the activity of D-mib-independent processes that may, or may not, be linked to Dl signaling.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "conceivable") (:form . "conceivable") (:end . 17)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "contribution") (:form . "contribution") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 67)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "mask") (:form . "masked") (:end . 83) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "d-mib-independent") (:form . "D-mib-independent")\n  (:end . 120) (:start . 103) (:id . 61))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 130)\n  (:start . 121) (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "link") (:form . "linked") (:end . 162)\n  (:start . 156) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 165) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "dl") (:form . "Dl") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 178)\n  (:start . 169) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x5.286.1) (:span 136 151)) ((:id . :x5.286.2) (:span 6 17)))\n (:hscopes ((:id . :x5.286.1) (:span 136 178))\n  ((:id . :x5.286.2) (:span 6 178)))\n (:identifiers (:sid . :s5.286) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101696@unknown@formal@none@1@S@We have also shown that, reciprocally, Neur and D-mib may similarly regulate Ser.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "RB") (:stem . "reciprocally") (:form . "reciprocally") (:end . 37)\n  (:start . 25) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 43) (:start . 39)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 67)\n  (:start . 58) (:id . 54))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x5.287.1) (:span 54 57)))\n (:hscopes ((:id . :x5.287.1) (:span 54 80)))\n (:identifiers (:sid . :s5.287) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101697@unknown@formal@none@1@S@Neur and D-mib were shown to similarly promote down-regulation of Ser from the cell surface when overexpressed (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data).@(((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 110) (:start . 97) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Lai") (:form . "Lai") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Roegiers") (:form . "Roegiers") (:end . 134)\n  (:start . 126) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "X.") (:form . "X.") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Qin") (:form . "Qin") (:end . 142) (:start . 139)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Le") (:form . "Le") (:end . 149) (:start . 147)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Borgne") (:form . "Borgne") (:end . 156)\n  (:start . 150) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 160) (:start . 158)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Schweisguth") (:form . "Schweisguth") (:end . 172)\n  (:start . 161) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 173) (:start . 172)\n  (:id . 76))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 176) (:start . 174)\n  (:id . 77))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 180) (:start . 177)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 193)\n  (:start . 182) (:id . 80))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 198)\n  (:start . 194) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s5.288) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101698@unknown@formal@none@1@S@Moreover, D-mib binds Ser (E. C. Lai, F. Roegiers, X. Qin, R. Le Borgne, F. Schweisguth, et al., unpublished data) and regulates Ser signaling (this study).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "E.") (:form . "E.") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Lai") (:form . "Lai") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 40) (:start . 38)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Roegiers") (:form . "Roegiers") (:end . 49)\n  (:start . 41) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "X.") (:form . "X.") (:end . 53) (:start . 51)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Qin") (:form . "Qin") (:end . 57) (:start . 54)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 61) (:start . 59)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Le") (:form . "Le") (:end . 64) (:start . 62)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Borgne") (:form . "Borgne") (:end . 71)\n  (:start . 65) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "F.") (:form . "F.") (:end . 75) (:start . 73)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Schweisguth") (:form . "Schweisguth") (:end . 87)\n  (:start . 76) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 64))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 91) (:start . 89)\n  (:id . 65))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 95) (:start . 92)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 108)\n  (:start . 97) (:id . 68))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 113)\n  (:start . 109) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 128)\n  (:start . 119) (:id . 72))\n ((:tag . "NN") (:stem . "ser") (:form . "Ser") (:end . 132) (:start . 129)\n  (:id . 73))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 142)\n  (:start . 133) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 148) (:start . 144)\n  (:id . 76))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 154)\n  (:start . 149) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 155) (:start . 154)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s5.289) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101700@unknown@formal@none@1@S@However, the ability of Neur to rescue the D-mib mutant wing phenotype when expressed in dorsal cells strongly indicates that Neur can promote Ser signaling.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ability") (:form . "ability") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 55)\n  (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 70)\n  (:start . 61) (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "dorsal") (:form . "dorsal") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 110)\n  (:start . 102) (:id . 60))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 156)\n  (:start . 147) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x5.291.1) (:span 131 134))\n  ((:id . :x5.291.2) (:span 111 125)))\n (:hscopes ((:id . :x5.291.1) (:span 126 156))\n  ((:id . :x5.291.2) (:span 111 156)))\n (:identifiers (:sid . :s5.291) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101701@unknown@formal@none@1@S@Together, these data indicate that Neur and D-mib have similar molecular activities.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 49) (:start . 44)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 83)\n  (:start . 73) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x5.292.1) (:span 21 34)))\n (:hscopes ((:id . :x5.292.1) (:span 21 83)))\n (:identifiers (:sid . :s5.292) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101702@unknown@formal@none@1@S@D-mib and Neur may have identical molecular activities but distinct expression patterns, hence distinct functions at the level of the organism.@(((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 87)\n  (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "RB") (:stem . "hence") (:form . "hence") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 113)\n  (:start . 104) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 126)\n  (:start . 121) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x5.293.1) (:span 15 18)))\n (:hscopes ((:id . :x5.293.1) (:span 15 142)))\n (:identifiers (:sid . :s5.293) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101703@unknown@formal@none@1@S@Consistent with this possibility, D-mib is uniformly distributed in imaginal discs, whereas Neur is specifically detected in sensory cells [52].@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "uniformly") (:form . "uniformly") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 82) (:start . 77)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 96) (:start . 92)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 112)\n  (:start . 100) (:id . 58))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 121)\n  (:start . 113) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 132)\n  (:start . 125) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 143) (:start . 142)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s5.294) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101704@unknown@formal@none@1@S@Importantly, the rescue of the D-mib mutant phenotype by ectopic expression of Neur strongly supports this interpretation.@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 64)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 92)\n  (:start . 84) (:id . 56))\n ((:tag . "VBZ") (:stem . "support") (:form . "supports") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "interpretation") (:form . "interpretation")\n  (:end . 121) (:start . 107) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x5.295.1) (:span 93 101)))\n (:hscopes ((:id . :x5.295.1) (:span 93 121)))\n (:identifiers (:sid . :s5.295) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101705@unknown@formal@none@1@S@This result further suggests that Neur can regulate Ser signaling.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x5.296.1) (:span 39 42)) ((:id . :x5.296.2) (:span 20 28)))\n (:hscopes ((:id . :x5.296.1) (:span 39 65))\n  ((:id . :x5.296.2) (:span 20 65)))\n (:identifiers (:sid . :s5.296) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101706@unknown@formal@none@1@S@Consistent with this idea, overexpression of Neur in imaginal discs resulted in a strong reduction of Ser accumulation at the apical cortex (data not shown).@(((:tag . "JJ") (:stem . "consistent") (:form . "Consistent") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 41) (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 98)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 118)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "apical") (:form . "apical") (:end . 132)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "cortex") (:form . "cortex") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 141) (:start . 140)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 145)\n  (:start . 141) (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 149) (:start . 146)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 155)\n  (:start . 150) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x5.297.1) (:span 146 149)))\n (:nscopes ((:id . :x5.297.1) (:span 146 156)))\n (:identifiers (:sid . :s5.297) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101707@unknown@formal@none@1@S@Thus, despite their obvious structural differences, Neur and D-mib appear to act similarly to promote the endocytosis of Dl and Ser.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 19)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 73)\n  (:start . 67) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "RB") (:stem . "similarly") (:form . "similarly") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "endocytosis") (:form . "endocytosis") (:end . 117)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Dl") (:form . "Dl") (:end . 123) (:start . 121)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 131) (:start . 128)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x5.298.1) (:span 67 73)))\n (:hscopes ((:id . :x5.298.1) (:span 52 131)))\n (:identifiers (:sid . :s5.298) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101708@unknown@formal@none@1@S@Nevertheless, our observation that D-mib could not compensate for the loss of neur activity in the embryo indicates that D-mib and Neur have overlapping rather than identical molecular activities.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "compensate") (:form . "compensate") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "neur") (:form . "neur") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "embryo") (:form . "embryo") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 115)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 126)\n  (:start . 121) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 152)\n  (:start . 141) (:id . 66))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 164) (:start . 160)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 174)\n  (:start . 165) (:id . 69))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 184)\n  (:start . 175) (:id . 70))\n ((:tag . "NNS") (:stem . "activity") (:form . "activities") (:end . 195)\n  (:start . 185) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x5.299.2) (:span 106 120)))\n (:ncues ((:id . :x5.299.1) (:span 153 164))\n  ((:id . :x5.299.3) (:span 41 50)))\n (:hscopes ((:id . :x5.299.2) (:span 106 195)))\n (:nscopes ((:id . :x5.299.1) (:span 153 195))\n  ((:id . :x5.299.3) (:span 41 105)))\n (:identifiers (:sid . :s5.299) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101710@unknown@formal@none@1@S@The conservation from Drosophila to mammals of these two structurally distinct but functionally similar E3 ubiquitin ligases is likely to reflect a combination of evolutionary advantages associated with: (i) specialized expression pattern, as evidenced by the cell-specific expression of the neur gene in sensory organ precursor cells [52]; (ii) specialized function, as suggested by the role of murine MIB in TNF?? signaling [32]; (iii) regulation of protein stability, localization, and/or activity.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 32)\n  (:start . 22) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . 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"role") (:end . 392) (:start . 388)\n  (:id . 107))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 395) (:start . 393)\n  (:id . 108))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 402)\n  (:start . 396) (:id . 109))\n ((:tag . "NNP") (:stem . "MIB") (:form . "MIB") (:end . 406) (:start . 403)\n  (:id . 110))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 409) (:start . 407)\n  (:id . 111))\n ((:tag . "NNP") (:stem . "TNF") (:form . "TNF") (:end . 413) (:start . 410)\n  (:id . 112))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 414) (:start . 413)\n  (:id . 113))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 415) (:start . 414)\n  (:id . 114))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 425)\n  (:start . 416) (:id . 115))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 427) (:start . 426)\n  (:id . 116))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 429) (:start . 427)\n  (:id . 117))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 430) (:start . 429)\n  (:id . 118))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 431) (:start . 430)\n  (:id . 119))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 433) (:start . 432)\n  (:id . 120))\n ((:tag . "LS") (:stem . "iii") (:form . "iii") (:end . 436) (:start . 433)\n  (:id . 121))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 437) (:start . 436)\n  (:id . 122))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 448)\n  (:start . 438) (:id . 123))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 451) (:start . 449)\n  (:id . 124))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 459)\n  (:start . 452) (:id . 125))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 469)\n  (:start . 460) (:id . 126))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 470) (:start . 469)\n  (:id . 127))\n ((:tag . "NN") (:stem . "localization") (:form . "localization") (:end . 483)\n  (:start . 471) (:id . 128))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 484) (:start . 483)\n  (:id . 129))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 491)\n  (:start . 485) (:id . 130))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 500)\n  (:start . 492) (:id . 131))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 501) (:start . 500)\n  (:id . 132)))@@@1@91@((:hcues ((:id . :x5.301.1) (:span 371 380))\n  ((:id . :x5.301.2) (:span 128 134)))\n (:hscopes ((:id . :x5.301.1) (:span 371 425))\n  ((:id . :x5.301.2) (:span 0 500)))\n (:identifiers (:sid . :s5.301) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101711@unknown@formal@none@1@S@For instance, Neur, but not D-mib, localizes asymmetrically during asymmetric sensory organ precursor cell divisions [22].@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Neur") (:form . "Neur") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "localize") (:form . "localizes") (:end . 44)\n  (:start . 35) (:id . 51))\n ((:tag . "RB") (:stem . "asymmetrically") (:form . "asymmetrically")\n  (:end . 59) (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "JJ") (:stem . "asymmetric") (:form . "asymmetric") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "sensory") (:form . "sensory") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "precursor") (:form . "precursor") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "division") (:form . "divisions") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x5.302.1) (:span 24 27)))\n (:nscopes ((:id . :x5.302.1) (:span 24 33)))\n (:identifiers (:sid . :s5.302) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101712@unknown@formal@none@1@S@Materials and Methods@(((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 21)\n  (:start . 14) (:id . 44)))@@@1@3@((:identifiers (:sid . :s5.303) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101713@unknown@formal@none@1@S@Flies.@(((:tag . "NNS") (:stem . "fly") (:form . "Flies") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 6) (:start . 5) (:id . 43)))@@@1@2@((:identifiers (:sid . :s5.304) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101714@unknown@formal@none@1@S@The D-mib1 mutation corresponds to the EY97600 P-element insertion generated by the Gene Disruption Project (http://flypush.imgen.bcm.tmc.edu/pscreen/).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 31)\n  (:start . 20) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "EY97600") (:form . "EY97600") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Gene") (:form . "Gene") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Disruption") (:form . "Disruption") (:end . 99)\n  (:start . 89) (:id . 55))\n ((:tag . "NNP") (:stem . "Project") (:form . "Project") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 109) (:start . 108)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "http://flypush.imgen.bcm.tmc.edu/pscreen/")\n  (:form . "http://flypush.imgen.bcm.tmc.edu/pscreen/") (:end . 150)\n  (:start . 109) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s5.305) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101715@unknown@formal@none@1@S@The D-mib2 allele was selected as w- D-mib mutant derivative by imprecise excision of the EY97600 P-element.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "allele") (:form . "allele") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "w-") (:form . "w-") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-mib") (:form . "D-mib") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "derivative") (:form . "derivative") (:end . 60)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "imprecise") (:form . "imprecise") (:end . 73)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "excision") (:form . "excision") (:end . 82)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "EY97600") (:form . "EY97600") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.306) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101716@unknown@formal@none@1@S@The precise breakpoints of the D-mib2 deletion were determined by sequencing a PCR fragment amplified from genomic DNA prepared from D-mib2 homozygous larvae.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "breakpoint") (:form . "breakpoints") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "deletion") (:form . "deletion") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "sequence") (:form . "sequencing") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 114)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 127)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 139)\n  (:start . 133) (:id . 62))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 150)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 157)\n  (:start . 151) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s5.307) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101717@unknown@formal@none@1@S@The l(3)72CdaJ12 and l(3)72CdaI5 alleles originally isolated by [35] failed to complement the D-mib1 and D-mib2 mutations and were renamed D-mib3 and D-mib4.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "l(3)72CdaJ12") (:form . "l(3)72CdaJ12") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "CD") (:stem . "l(3)72CdaI5") (:form . "l(3)72CdaI5") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 60)\n  (:start . 52) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 67) (:start . 65)\n  (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 75) (:start . 69)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "VB") (:stem . "complement") (:form . "complement") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 56))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 111)\n  (:start . 105) (:id . 59))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "rename") (:form . "renamed") (:end . 138)\n  (:start . 131) (:id . 63))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 145)\n  (:start . 139) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "d-mib4") (:form . "D-mib4") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x5.308.1) (:span 69 75)))\n (:nscopes ((:id . :x5.308.1) (:span 69 121)))\n (:identifiers (:sid . :s5.308) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101718@unknown@formal@none@1@S@The D-mib1, D-mib2, and D-mib3 alleles appear to be genetically null alleles since the phenotypes of D-mib1/D-mib1 and D-mib1/D-mib3 mutant pupae are indistinguishable from the ones seen in D-mib1/D-mib2 and D-mib2/D-mib3 pupae.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "d-mib1") (:form . "D-mib1") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "D-mib2") (:form . "D-mib2") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 23) (:start . 20)\n  (:id . 47))\n ((:tag . "NN") (:stem . "d-mib3") (:form . "D-mib3") (:end . 30)\n  (:start . 24) (:id . 48))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 45)\n  (:start . 39) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 51) (:start . 49)\n  (:id . 52))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 63)\n  (:start . 52) (:id . 53))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "d-mib1/d-mib1") (:form . "D-mib1/D-mib1")\n  (:end . 114) (:start . 101) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "d-mib1/d-mib3") (:form . "D-mib1/D-mib3")\n  (:end . 132) (:start . 119) (:id . 62))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 139)\n  (:start . 133) (:id . 63))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "indistinguishable") (:form . "indistinguishable")\n  (:end . 167) (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 172) (:start . 168)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 181) (:start . 177)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 186) (:start . 182)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "NN") (:stem . "d-mib1/d-mib2") (:form . "D-mib1/D-mib2")\n  (:end . 203) (:start . 190) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 73))\n ((:tag . "NN") (:stem . "d-mib2/d-mib3") (:form . "D-mib2/D-mib3")\n  (:end . 221) (:start . 208) (:id . 74))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 227)\n  (:start . 222) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x5.309.1) (:span 39 45)))\n (:hscopes ((:id . :x5.309.1) (:span 0 76)))\n (:identifiers (:sid . :s5.309) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101720@unknown@formal@none@1@S@Genomic DNA from l(3)72Cda/D-mib2 mutant pupae was used as control for polymorphism.@(((:tag . "JJ") (:stem . "genomic") (:form . "Genomic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "l(3)72Cda/D-mib2") (:form . "l(3)72Cda/D-mib2")\n  (:end . 33) (:start . 17) (:id . 45))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "polymorphism") (:form . "polymorphism") (:end . 83)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s5.311) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101721@unknown@formal@none@1@S@D-mib2 mutant clones were generated in y w hs-flp;FRT2A D-mib2/FRT2A M(3)i55 ubi-nlsGFP larvae.@(((:tag . "NN") (:stem . "d-mib2") (:form . "D-mib2") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "y") (:form . "y") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "w") (:form . "w") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "hs-flp;FRT2A") (:form . "hs-flp;FRT2A") (:end . 55)\n  (:start . 43) (:id . 50))\n ((:tag . "NNP") (:stem . "D-mib2/FRT2A") (:form . "D-mib2/FRT2A") (:end . 68)\n  (:start . 56) (:id . 51))\n ((:tag . "NNP") (:stem . "M(3)i55") (:form . "M(3)i55") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NNP") (:stem . "ubi-nlsGFP") (:form . "ubi-nlsGFP") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 94)\n  (:start . 88) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s5.312) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101722@unknown@formal@none@1@S@neur1F65 mutant clones were generated as previously described [22].@(((:tag . "NN") (:stem . "neur1f65") (:form . "neur1F65") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "clone") (:form . "clones") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 61)\n  (:start . 52) (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 63) (:start . 62)\n  (:id . 50))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s5.313) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101723@unknown@formal@none@1@S@UAS-D-mib and UAS-YFP::D-mib lines were generated via standard P-element transformation.@(((:tag . "NNP") (:stem . "UAS-D-mib") (:form . "UAS-D-mib") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "UAS-YFP::D-mib") (:form . "UAS-YFP::D-mib")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 34) (:start . 29)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 49)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 87) (:start . 73) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 88) (:start . 87)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s5.314) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101724@unknown@formal@none@1@S@These constructs were derived from the SD05267 cDNA obtained from ResGen (Invitrogen, Carlsbad, California, United States).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "SD05267") (:form . "SD05267") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ResGen") (:form . "ResGen") (:end . 72)\n  (:start . 66) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Invitrogen") (:form . "Invitrogen") (:end . 84)\n  (:start . 74) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Carlsbad") (:form . "Carlsbad") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "California") (:form . "California") (:end . 106)\n  (:start . 96) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s5.315) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101725@unknown@formal@none@1@S@Cloning details for these constructs are available upon request.@(((:tag . "NN") (:stem . "cloning") (:form . "Cloning") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "detail") (:form . "details") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "request") (:form . "request") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s5.316) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101726@unknown@formal@none@1@S@UAS-Dl (gift from M. Muskavith), UAS-Ser (gift from R. Fleming), UAS-Neur (gift from C. Delidakis), UAS-Ncdc10 (gift of T. Klein), Ser-GAL4 lines, and Ser mutant alleles are described in FlyBase (http://flybase.bio.indiana.edu/).@(((:tag . "NNP") (:stem . "UAS-Dl") (:form . "UAS-Dl") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "gift") (:form . "gift") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "M.") (:form . "M.") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Muskavith") (:form . "Muskavith") (:end . 30)\n  (:start . 21) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "UAS-Ser") (:form . "UAS-Ser") (:end . 40)\n  (:start . 33) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 51))\n ((:tag . "NN") (:stem . "gift") (:form . "gift") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 54) (:start . 52)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fleming") (:form . "Fleming") (:end . 62)\n  (:start . 55) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "UAS-Neur") (:form . "UAS-Neur") (:end . 73)\n  (:start . 65) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gift") (:form . "gift") (:end . 79) (:start . 75)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 84) (:start . 80)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 87) (:start . 85)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Delidakis") (:form . "Delidakis") (:end . 97)\n  (:start . 88) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "UAS-Ncdc10") (:form . "UAS-Ncdc10") (:end . 110)\n  (:start . 100) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gift") (:form . "gift") (:end . 116) (:start . 112)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "T.") (:form . "T.") (:end . 122) (:start . 120)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Klein") (:form . "Klein") (:end . 128)\n  (:start . 123) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 129) (:start . 128)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ser-gal4") (:form . "Ser-GAL4") (:end . 139)\n  (:start . 131) (:id . 74))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 145)\n  (:start . 140) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Ser") (:form . "Ser") (:end . 154) (:start . 151)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 161)\n  (:start . 155) (:id . 79))\n ((:tag . "NNS") (:stem . "allele") (:form . "alleles") (:end . 169)\n  (:start . 162) (:id . 80))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 173) (:start . 170)\n  (:id . 81))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 183)\n  (:start . 174) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "FlyBase") (:form . "FlyBase") (:end . 194)\n  (:start . 187) (:id . 84))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 196) (:start . 195)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "http://flybase.bio.indiana.edu/")\n  (:form . "http://flybase.bio.indiana.edu/") (:end . 227) (:start . 196)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s5.317) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101727@unknown@formal@none@1@S@Antibodies.@(((:tag . "NNS") (:stem . "antibody") (:form . "Antibodies") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 11) (:start . 10)\n  (:id . 43)))@@@1@2@((:identifiers (:sid . :s5.318) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101728@unknown@formal@none@1@S@Dissected imaginal discs were fixed in 4% paraformaldehyde (15 min) and incubated with antibodies at room temperature in PBS 1X with 0.1% TritonX-100.@(((:tag . "VBN") (:stem . "dissect") (:form . "Dissected") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 24) (:start . 19)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "fix") (:form . "fixed") (:end . 35) (:start . 30)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "paraformaldehyde") (:form . "paraformaldehyde")\n  (:end . 58) (:start . 42) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "incubate") (:form . "incubated") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 97)\n  (:start . 87) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "room") (:form . "room") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "temperature") (:form . "temperature") (:end . 117)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "NN") (:stem . "1x") (:form . "1X") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "CD") (:stem . "0.1") (:form . "0.1") (:end . 136) (:start . 133)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tritonx-100") (:form . "TritonX-100") (:end . 149)\n  (:start . 138) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s5.319) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101730@unknown@formal@none@1@S@Immunopurified anti-D-mib antibodies (rabbit 541) were used (immunofluorescence, 1:100; Western blot, 1:1,000).@(((:tag . "VBN") (:stem . "immunopurifie") (:form . "Immunopurified")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "anti-d-mib") (:form . "anti-D-mib") (:end . 25)\n  (:start . 15) (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 36)\n  (:start . 26) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rabbit") (:form . "rabbit") (:end . 44)\n  (:start . 38) (:id . 46))\n ((:tag . "CD") (:stem . "541") (:form . "541") (:end . 48) (:start . 45)\n  (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "immunofluorescence") (:form . "immunofluorescence")\n  (:end . 79) (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 53))\n ((:tag . "CD") (:stem . "1:100") (:form . "1:100") (:end . 86) (:start . 81)\n  (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "western") (:form . "Western") (:end . 95)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "blot") (:form . "blot") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "CD") (:stem . "1:1,000") (:form . "1:1,000") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s5.321) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101731@unknown@formal@none@1@S@Other primary antibodies were mouse anti-Cut (2B10; Developmental Studies Hybridoma Bank [DSHB, Iowa City, Iowa, United States]; 1:500); rat anti-DE-Cadherin (gift from T. Uemura; 1:50); guinea pig anti-Discs-large (gift from P. Bryant; 1:3,000); anti-?-galactosidase (Cappel [MP Biomedicals, Irvine, California, United States]; 1:1,000); mouse anti-DeltaECD (C594.9B; DSHB; 1:1,000); mouse anti-NotchECD (C548.2H; DSHB; 1:1,000); rat anti-Ser (gift from K. Irvine; 1:2,000); rat anti-Ser (gift from S. Cohen; 1:200); rabbit anti-Ser (gift from E. Knust; 1:10); and guinea pig anti-Senseless (gift from H. Bellen; 1:3,000).@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . 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5101732@unknown@formal@none@1@S@Cy2-, Cy3-, and Cy5-coupled secondary antibodies were from Jackson Laboratory (Bar Harbor, Maine, United States).@(((:tag . "NNP") (:stem . "Cy2-") (:form . "Cy2-") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "cy3-") (:form . "Cy3-") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "cy5-coupled") (:form . "Cy5-coupled") (:end . 27)\n  (:start . 16) (:id . 47))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Jackson") (:form . "Jackson") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "NNP") (:stem . "Laboratory") (:form . "Laboratory") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Bar") (:form . "Bar") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Harbor") (:form . "Harbor") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Maine") (:form . "Maine") (:end . 96) (:start . 91)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 104)\n  (:start . 98) (:id . 60))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 111)\n  (:start . 105) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s5.323) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101733@unknown@formal@none@1@S@Alexa488-coupled secondary antibodies and phalloidin were from Molecular Probes (Eugene, Oregon, United States).@(((:tag . "JJ") (:stem . "alexa488-coupled") (:form . "Alexa488-coupled")\n  (:end . 16) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 26)\n  (:start . 17) (:id . 43))\n ((:tag . "NNS") (:stem . "antibody") (:form . "antibodies") (:end . 37)\n  (:start . 27) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 45))\n ((:tag . "NN") (:stem . "phalloidin") (:form . "phalloidin") (:end . 52)\n  (:start . 42) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 57) (:start . 53)\n  (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Molecular") (:form . "Molecular") (:end . 72)\n  (:start . 63) (:id . 49))\n ((:tag . "NNP") (:stem . "Probes") (:form . "Probes") (:end . 79)\n  (:start . 73) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Eugene") (:form . "Eugene") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Oregon") (:form . "Oregon") (:end . 95)\n  (:start . 89) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 103)\n  (:start . 97) (:id . 56))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 110)\n  (:start . 104) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s5.324) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101734@unknown@formal@none@1@S@Images were acquired on a Leica (Wetzlar, Germany) SP2 microscope and assembled using Adobe Photoshop (Adobe Systems, San Jose, California, United States).@(((:tag . "NNS") (:stem . "image") (:form . "Images") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "acquire") (:form . "acquired") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Leica") (:form . "Leica") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Wetzlar") (:form . "Wetzlar") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Germany") (:form . "Germany") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "sp2") (:form . "SP2") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 65)\n  (:start . 55) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 79)\n  (:start . 70) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Adobe") (:form . "Adobe") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Photoshop") (:form . "Photoshop") (:end . 101)\n  (:start . 92) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Adobe") (:form . "Adobe") (:end . 108)\n  (:start . 103) (:id . 61))\n ((:tag . "NNP") (:stem . "Systems") (:form . "Systems") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "San") (:form . "San") (:end . 121) (:start . 118)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Jose") (:form . "Jose") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "California") (:form . "California") (:end . 138)\n  (:start . 128) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 146)\n  (:start . 140) (:id . 69))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 153)\n  (:start . 147) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 154) (:start . 153)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s5.325) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101735@unknown@formal@none@1@S@Endocytosis assay.@(((:tag . "NNP") (:stem . "Endocytosis") (:form . "Endocytosis") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 17) (:start . 12)\n  (:id . 43))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 18) (:start . 17)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s5.326) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101736@unknown@formal@none@1@S@Third instar larvae wing discs were dissected in Schneider's Drosophila medium (Gibco BRL, San Diego, California, United States) containing 10% fetal calf serum (Gibco BRL).@(((:tag . "JJ") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "larvae") (:form . "larvae") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "dissect") (:form . "dissected") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Schneider") (:form . "Schneider") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Gibco") (:form . "Gibco") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BRL") (:form . "BRL") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "San") (:form . "San") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Diego") (:form . "Diego") (:end . 100)\n  (:start . 95) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "California") (:form . "California") (:end . 112)\n  (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 120)\n  (:start . 114) (:id . 63))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 139)\n  (:start . 129) (:id . 66))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "fetal") (:form . "fetal") (:end . 149)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "calf") (:form . "calf") (:end . 154) (:start . 150)\n  (:id . 70))\n ((:tag . "NN") (:stem . "serum") (:form . "serum") (:end . 160)\n  (:start . 155) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Gibco") (:form . "Gibco") (:end . 167)\n  (:start . 162) (:id . 73))\n ((:tag . "NNP") (:stem . "BRL") (:form . "BRL") (:end . 171) (:start . 168)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s5.327) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101737@unknown@formal@none@1@S@Wing discs were cut between the wing pouch and the thorax to facilitate antibody diffusion.@(((:tag . "VBG") (:stem . "wing") (:form . "Wing") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "cut") (:form . "cut") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "wing") (:form . "wing") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pouch") (:form . "pouch") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "thorax") (:form . "thorax") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "VB") (:stem . "facilitate") (:form . "facilitate") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "diffusion") (:form . "diffusion") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s5.328) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101738@unknown@formal@none@1@S@Wing discs were cultured for 15 min with mouse anti-Dl (C594–9B at 1:100) and rat anti-Ser antibody (1:500; from K. Irvine).@(((:tag . "VBG") (:stem . "wing") (:form . "Wing") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mouse") (:form . "mouse") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "anti-dl") (:form . "anti-Dl") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C594–9B") (:form . "C594–9B") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1:100") (:form . "1:100") (:end . 72) (:start . 67)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rat") (:form . "rat") (:end . 81) (:start . 78)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-ser") (:form . "anti-Ser") (:end . 90)\n  (:start . 82) (:id . 59))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1:500") (:form . "1:500") (:end . 106)\n  (:start . 101) (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 112) (:start . 108)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "K.") (:form . "K.") (:end . 115) (:start . 113)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Irvine") (:form . "Irvine") (:end . 122)\n  (:start . 116) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 123) (:start . 122)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s5.329) (:did . :pmc1064853) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101740@unknown@formal@none@1@S@RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons@(((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Core") (:form . "Core") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Recombination") (:form . "Recombination")\n  (:end . 33) (:start . 20) (:id . 46))\n ((:tag . "NNP") (:stem . "Signal") (:form . "Signal") (:end . 40)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "Sequence") (:form . "Sequences") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "Were") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "derive") (:form . "Derived") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 68) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 76)\n  (:start . 69) (:id . 52))\n ((:tag . "NNPS") (:stem . "Transposon") (:form . "Transposons") (:end . 88)\n  (:start . 77) (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.1) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5101741@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s6.2) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101742@unknown@formal@none@1@S@The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have emerged approximately 500 million years ago from transposon-encoded proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 23) (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "jaw") (:form . "jawed") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "catalyze") (:form . "catalyzed") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 96)\n  (:start . 88) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 146) (:start . 133) (:id . 64))\n ((:tag . "CD") (:stem . "500") (:form . "500") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "CD") (:stem . "million") (:form . "million") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "RB") (:stem . "ago") (:form . "ago") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 173) (:start . 169)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "transposon-encoded") (:form . "transposon-encoded")\n  (:end . 192) (:start . 174) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 201)\n  (:start . 193) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x6.3.1) (:span 108 116)))\n (:hscopes ((:id . :x6.3.1) (:span 98 201)))\n (:identifiers (:sid . :s6.3) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101743@unknown@formal@none@1@S@Yet no transposase sequence similar to RAG1 or RAG2 has been found.@(((:tag . "RB") (:stem . "yet") (:form . "Yet") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "transposase") (:form . "transposase") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG2") (:form . "RAG2") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x6.4.1) (:span 4 6)))\n (:nscopes ((:id . :x6.4.1) (:span 4 66)))\n (:identifiers (:sid . :s6.4) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101744@unknown@formal@none@1@S@Here we show that the approximately 600-amino acid “core” region of RAG1 required for its catalytic activity is significantly similar to the transposase encoded by DNA transposons that belong to the Transib superfamily.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 35) (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "600-amino") (:form . "600-amino") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "core") (:form . "core") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 81)\n  (:start . 73) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 89) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 99)\n  (:start . 90) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 125) (:start . 112) (:id . 62))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 136) (:start . 134)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "transposase") (:form . "transposase") (:end . 152)\n  (:start . 141) (:id . 66))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 160)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 163) (:start . 161)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 167) (:start . 164)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 179)\n  (:start . 168) (:id . 70))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 184) (:start . 180)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 191)\n  (:start . 185) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 206)\n  (:start . 199) (:id . 75))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 218)\n  (:start . 207) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s6.5) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101745@unknown@formal@none@1@S@This superfamily was discovered recently based on computational analysis of the fruit fly and African malaria mosquito genomes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 31)\n  (:start . 21) (:id . 45))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 40)\n  (:start . 32) (:id . 46))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 46) (:start . 41)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "computational") (:form . "computational")\n  (:end . 63) (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 72)\n  (:start . 64) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 75) (:start . 73)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 89) (:start . 86)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 118)\n  (:start . 110) (:id . 58))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 126)\n  (:start . 119) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 127) (:start . 126)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.6) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101746@unknown@formal@none@1@S@Transib transposons also are present in the genomes of sea urchin, yellow fever mosquito, silkworm, dog hookworm, hydra, and soybean rust.@(((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 19)\n  (:start . 8) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 24) (:start . 20)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 88)\n  (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "silkworm") (:form . "silkworm") (:end . 98)\n  (:start . 90) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dog") (:form . "dog") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hookworm") (:form . "hookworm") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "NN") (:stem . "soybean") (:form . "soybean") (:end . 132)\n  (:start . 125) (:id . 66))\n ((:tag . "NN") (:stem . "rust") (:form . "rust") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s6.7) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101747@unknown@formal@none@1@S@We demonstrate that recombination signal sequences (RSSs) were derived from terminal inverted repeats of an ancient Transib transposon.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 33) (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSSs") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "JJ") (:stem . "inverted") (:form . "inverted") (:end . 93)\n  (:start . 85) (:id . 55))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 101)\n  (:start . 94) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 134)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.8) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101748@unknown@formal@none@1@S@Furthermore, the critical DDE catalytic triad of RAG1 is shared with the Transib transposase as part of conserved motifs.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "dde") (:form . "DDE") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 80)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "transposase") (:form . "transposase") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 120)\n  (:start . 114) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.9) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101750@unknown@formal@none@1@S@Our results provide the first direct evidence linking RAG1 and RSSs to a specific superfamily of DNA transposons and indicate that the V(D)J machinery evolved from transposons.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "VBG") (:stem . "link") (:form . "linking") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "rss") (:form . "RSSs") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 93)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 112)\n  (:start . 101) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 140)\n  (:start . 135) (:id . 64))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 158)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 175)\n  (:start . 164) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x6.11.1) (:span 117 130)))\n (:hscopes ((:id . :x6.11.1) (:span 117 175)))\n (:identifiers (:sid . :s6.11) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101751@unknown@formal@none@1@S@We propose that only the RAG1 core was derived from the Transib transposase, whereas the N-terminal domain was assembled from separate proteins of unknown function that may still be active in sea urchin, lancelet, hydra, and starlet sea anemone.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "propose") (:form . "propose") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "transposase") (:form . "transposase") (:end . 75)\n  (:start . 64) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 99)\n  (:start . 89) (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 143)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 154)\n  (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 163)\n  (:start . 155) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 172) (:start . 169)\n  (:id . 69))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 178)\n  (:start . 173) (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 188)\n  (:start . 182) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 195) (:start . 192)\n  (:id . 74))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 202)\n  (:start . 196) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 76))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 212)\n  (:start . 204) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 78))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 219)\n  (:start . 214) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 81))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 232)\n  (:start . 225) (:id . 82))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 236) (:start . 233)\n  (:id . 83))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 244)\n  (:start . 237) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 245) (:start . 244)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x6.12.1) (:span 169 172)) ((:id . :x6.12.2) (:span 3 10)))\n (:hscopes ((:id . :x6.12.1) (:span 169 244))\n  ((:id . :x6.12.2) (:span 3 244)))\n (:identifiers (:sid . :s6.12) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101752@unknown@formal@none@1@S@We also suggest that the RAG2 protein was not encoded by ancient Transib transposons but emerged in jawed vertebrates as a counterpart of RAG1 necessary for the V(D)J recombination reaction.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 72)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 84)\n  (:start . 73) (:id . 55))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "emerge") (:form . "emerged") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "jaw") (:form . "jawed") (:end . 105) (:start . 100)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 117)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "counterpart") (:form . "counterpart") (:end . 134)\n  (:start . 123) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 142) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 152)\n  (:start . 143) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 156) (:start . 153)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 166)\n  (:start . 161) (:id . 69))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 180) (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x6.13.2) (:span 8 15)))\n (:ncues ((:id . :x6.13.1) (:span 42 45)))\n (:hscopes ((:id . :x6.13.2) (:span 8 189)))\n (:nscopes ((:id . :x6.13.1) (:span 21 84)))\n (:identifiers (:sid . :s6.13) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101753@unknown@formal@none@1@S@Introduction@(((:tag . "NN") (:stem . "introduction") (:form . "Introduction") (:end . 12)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s6.14) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101754@unknown@formal@none@1@S@The immune system of jawed vertebrates detects and destroys foreign invaders, including bacteria and viruses, by a specific response to an unlimited number of antigens expressed by them.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "jaw") (:form . "jawed") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 38)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "detect") (:form . "detects") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "destroy") (:form . "destroys") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "JJ") (:stem . "foreign") (:form . "foreign") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "invader") (:form . "invaders") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 96)\n  (:start . 88) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "virus") (:form . "viruses") (:end . 108)\n  (:start . 101) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 123)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 132)\n  (:start . 124) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "unlimited") (:form . "unlimited") (:end . 148)\n  (:start . 139) (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 155)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 167)\n  (:start . 159) (:id . 68))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 177)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 185) (:start . 181)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s6.15) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101755@unknown@formal@none@1@S@The antigens can be identified after they are specifically bound by surface receptors of vertebrate B and T immune cells (BCRs and TCRs, respectively).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "antigen") (:form . "antigens") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 58)\n  (:start . 46) (:id . 50))\n ((:tag . "VBN") (:stem . "bind") (:form . "bound") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "surface") (:form . "surface") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "b") (:form . "B") (:end . 101) (:start . 100)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 120)\n  (:start . 115) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . "NNPS") (:stem . "BCR") (:form . "BCRs") (:end . 126) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "NNPS") (:stem . "TCR") (:form . "TCRs") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 149)\n  (:start . 137) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.16) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101756@unknown@formal@none@1@S@Because the vast repertoire of BCRs and TCRs cannot be encoded genetically, ancestors of jawed vertebrates adopted an elegant combinatorial solution [1].@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "vast") (:form . "vast") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "repertoire") (:form . "repertoire") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNPS") (:stem . "BCR") (:form . "BCRs") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNPS") (:stem . "TCR") (:form . "TCRs") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cannot") (:form . "cannot") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 62)\n  (:start . 55) (:id . 52))\n ((:tag . "RB") (:stem . "genetically") (:form . "genetically") (:end . 74)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "ancestor") (:form . "ancestors") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "jaw") (:form . "jawed") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 106)\n  (:start . 95) (:id . 58))\n ((:tag . "VBD") (:stem . "adopt") (:form . "adopted") (:end . 114)\n  (:start . 107) (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "elegant") (:form . "elegant") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "JJ") (:stem . "combinatorial") (:form . "combinatorial")\n  (:end . 139) (:start . 126) (:id . 62))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 148)\n  (:start . 140) (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 150) (:start . 149)\n  (:id . 64))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 151) (:start . 150)\n  (:id . 65))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:ncues ((:id . :x6.17.1) (:span 45 51)))\n (:nscopes ((:id . :x6.17.1) (:span 8 74)))\n (:identifiers (:sid . :s6.17) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101757@unknown@formal@none@1@S@The variable portions of the BCR and TCR genes are composed of separate V (variable), D (diversity), and J (joining) segments, which are represented by fewer than a few hundred copies each.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "BCR") (:form . "BCR") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 83)\n  (:start . 75) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 87) (:start . 86)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 61))\n ((:tag . "NN") (:stem . "diversity") (:form . "diversity") (:end . 98)\n  (:start . 89) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 106) (:start . 105)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 108) (:start . 107)\n  (:id . 67))\n ((:tag . "NN") (:stem . "joining") (:form . "joining") (:end . 115)\n  (:start . 108) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 125)\n  (:start . 117) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 132)\n  (:start . 127) (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 136) (:start . 133)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 148)\n  (:start . 137) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 75))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 157) (:start . 152)\n  (:id . 76))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 162) (:start . 158)\n  (:id . 77))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 164) (:start . 163)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 168) (:start . 165)\n  (:id . 79))\n ((:tag . "CD") (:stem . "hundred") (:form . "hundred") (:end . 176)\n  (:start . 169) (:id . 80))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 183)\n  (:start . 177) (:id . 81))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 188) (:start . 184)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s6.18) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101758@unknown@formal@none@1@S@In a B and T cell site-specific recombination reaction, commonly known as V(D)J recombination, one V, one D, and one J segment are joined together into a single exon encoding the variable antigen-binding region of the receptor.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 6) (:start . 5)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 10) (:start . 7)\n  (:id . 45))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 12) (:start . 11)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 17) (:start . 13)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "site-specific") (:form . "site-specific")\n  (:end . 31) (:start . 18) (:id . 48))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 45) (:start . 32) (:id . 49))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "RB") (:stem . "commonly") (:form . "commonly") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 93) (:start . 80) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 116) (:start . 113)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 118) (:start . 117)\n  (:id . 66))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 126)\n  (:start . 119) (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "join") (:form . "joined") (:end . 137)\n  (:start . 131) (:id . 69))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 146)\n  (:start . 138) (:id . 70))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 151) (:start . 147)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 160)\n  (:start . 154) (:id . 73))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 165) (:start . 161)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 174)\n  (:start . 166) (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 187)\n  (:start . 179) (:id . 77))\n ((:tag . "JJ") (:stem . "antigen-binding") (:form . "antigen-binding")\n  (:end . 203) (:start . 188) (:id . 78))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 210)\n  (:start . 204) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 81))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 226)\n  (:start . 218) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s6.19) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101760@unknown@formal@none@1@S@In V(D)J recombination, DNA cleavage is catalyzed by two proteins encoded by the recombination-activating genes, approximately 1040-amino acid (aa) RAG1 and approximately 530-aa RAG2 [2,3].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 22) (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "catalyze") (:form . "catalyzed") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "recombination-activating")\n  (:form . "recombination-activating") (:end . 105) (:start . 81) (:id . 56))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 58))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 126) (:start . 113) (:id . 59))\n ((:tag . "JJ") (:stem . "1040-amino") (:form . "1040-amino") (:end . 137)\n  (:start . 127) (:id . 60))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 152) (:start . 148)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 66))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 170) (:start . 157) (:id . 67))\n ((:tag . "JJ") (:stem . "530-aa") (:form . "530-aa") (:end . 177)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 182) (:start . 178)\n  (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 184) (:start . 183)\n  (:id . 70))\n ((:tag . "CD") (:stem . "2,3") (:form . "2,3") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 188) (:start . 187)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s6.21) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101761@unknown@formal@none@1@S@The site specificity of the recombination is defined by the binding of RAG1/2 to RSSs flanking the V, D, and J segments [4].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 41) (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RAG1/2") (:form . "RAG1/2") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "rss") (:form . "RSSs") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 94)\n  (:start . 86) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 119)\n  (:start . 111) (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 121) (:start . 120)\n  (:id . 66))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 122) (:start . 121)\n  (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 123) (:start . 122)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.22) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101762@unknown@formal@none@1@S@All RSSs can be divided into two groups, referred to as RSS12 and RSS23, and consist of conserved heptamer and nonamer sequences separated by a variable spacer either 12 ± 1 (RSS12) or 23 ± 1 (RSS23) bp long [4–7].@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "RSS") (:form . "RSSs") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RSS23") (:form . "RSS23") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "consist") (:form . "consist") (:end . 84)\n  (:start . 77) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 97)\n  (:start . 88) (:id . 61))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 106)\n  (:start . 98) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 118)\n  (:start . 111) (:id . 64))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 128)\n  (:start . 119) (:id . 65))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 138)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 152)\n  (:start . 144) (:id . 69))\n ((:tag . "NN") (:stem . "spacer") (:form . "spacer") (:end . 159)\n  (:start . 153) (:id . 70))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 166)\n  (:start . 160) (:id . 71))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 169) (:start . 167)\n  (:id . 72))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 180)\n  (:start . 175) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 184) (:start . 182)\n  (:id . 78))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 187) (:start . 185)\n  (:id . 79))\n ((:tag . "NN") (:stem . "±") (:form . "±") (:end . 189) (:start . 188)\n  (:id . 80))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 191) (:start . 190)\n  (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 193) (:start . 192)\n  (:id . 82))\n ((:tag . "NN") (:stem . "rss23") (:form . "RSS23") (:end . 198)\n  (:start . 193) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 199) (:start . 198)\n  (:id . 84))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 202) (:start . 200)\n  (:id . 85))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 207) (:start . 203)\n  (:id . 86))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 209) (:start . 208)\n  (:id . 87))\n ((:tag . "CD") (:stem . "4–7") (:form . "4–7") (:end . 212) (:start . 209)\n  (:id . 88))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 213) (:start . 212)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s6.23) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101763@unknown@formal@none@1@S@During V(D)J recombination, RAG1/2 complex binds one RSS12 and one RSS23, bringing them into juxtaposition, and cuts the chromosome between the RSS heptamers and the corresponding V and D, D and J, or V and J coding segments [3,8].@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1/2") (:form . "RAG1/2") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rss23") (:form . "RSS23") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bring") (:form . "bringing") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 92) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "juxtaposition") (:form . "juxtaposition")\n  (:end . 106) (:start . 93) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "cut") (:form . "cuts") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 131)\n  (:start . 121) (:id . 63))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 147) (:start . 144)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "heptamer") (:form . "heptamers") (:end . 157)\n  (:start . 148) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 179)\n  (:start . 166) (:id . 70))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 181) (:start . 180)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 187) (:start . 186)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 190) (:start . 189)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 78))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 200) (:start . 198)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "V") (:form . "V") (:end . 202) (:start . 201)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 208) (:start . 207)\n  (:id . 82))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 215)\n  (:start . 209) (:id . 83))\n ((:tag . "NNS") (:stem . "segment") (:form . "segments") (:end . 224)\n  (:start . 216) (:id . 84))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 226) (:start . 225)\n  (:id . 85))\n ((:tag . "CD") (:stem . "3,8") (:form . "3,8") (:end . 229) (:start . 226)\n  (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 230) (:start . 229)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s6.24) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101764@unknown@formal@none@1@S@A rule requiring that efficient V(D)J recombination occur between RSS12 and RSS23 is known as the “12/23” rule [1].@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "require") (:form . "requiring") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 51) (:start . 38) (:id . 48))\n ((:tag . "VBP") (:stem . "occur") (:form . "occur") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 71) (:start . 66)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RSS23") (:form . "RSS23") (:end . 81) (:start . 76)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "12/23") (:form . "12/23") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 113) (:start . 112)\n  (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 114) (:start . 113)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s6.25) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101765@unknown@formal@none@1@S@Even prior to the discovery of RAG1 and RAG2, it had been suggested that the first two RSSs were originally terminal inverted repeats (TIRs) of an ancient transposon whose accidental insertion into a gene ancestral to BCR and TCR, followed by gene duplications, triggered the emergence of the V(D)J machinery [4].@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG2") (:form . "RAG2") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 57) (:start . 53)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 67)\n  (:start . 58) (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 82) (:start . 77)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "rss") (:form . "RSSs") (:end . 91) (:start . 87)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 107)\n  (:start . 97) (:id . 62))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 116)\n  (:start . 108) (:id . 63))\n ((:tag . "JJ") (:stem . "inverted") (:form . "inverted") (:end . 125)\n  (:start . 117) (:id . 64))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 133)\n  (:start . 126) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 139) (:start . 135)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 146) (:start . 144)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 154)\n  (:start . 147) (:id . 71))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 165)\n  (:start . 155) (:id . 72))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . "JJ") (:stem . "accidental") (:form . "accidental") (:end . 182)\n  (:start . 172) (:id . 74))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 192)\n  (:start . 183) (:id . 75))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 197) (:start . 193)\n  (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 199) (:start . 198)\n  (:id . 77))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 204) (:start . 200)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "ancestral") (:form . "ancestral") (:end . 214)\n  (:start . 205) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 217) (:start . 215)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "BCR") (:form . "BCR") (:end . 221) (:start . 218)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "TCR") (:form . "TCR") (:end . 229) (:start . 226)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 239)\n  (:start . 231) (:id . 85))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 242) (:start . 240)\n  (:id . 86))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 247) (:start . 243)\n  (:id . 87))\n ((:tag . "NNS") (:stem . "duplication") (:form . "duplications") (:end . 260)\n  (:start . 248) (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 261) (:start . 260)\n  (:id . 89))\n ((:tag . "VBD") (:stem . "trigger") (:form . "triggered") (:end . 271)\n  (:start . 262) (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 275) (:start . 272)\n  (:id . 91))\n ((:tag . "NN") (:stem . "emergence") (:form . "emergence") (:end . 285)\n  (:start . 276) (:id . 92))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 288) (:start . 286)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 292) (:start . 289)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 298)\n  (:start . 293) (:id . 95))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 308)\n  (:start . 299) (:id . 96))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 310) (:start . 309)\n  (:id . 97))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 311) (:start . 310)\n  (:id . 98))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 312) (:start . 311)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 313) (:start . 312)\n  (:id . 100)))@@@1@59@((:hcues ((:id . :x6.26.1) (:span 58 67)))\n (:hscopes ((:id . :x6.26.1) (:span 58 308)))\n (:identifiers (:sid . :s6.26) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101766@unknown@formal@none@1@S@Later, this model was expanded by the suggestion that both RAG1 and RAG2 might have evolved from a transposase (TPase) that catalyzed transpositions of ancient transposons flanked by TIRs that were precursors of RSSs [9].@(((:tag . "RB") (:stem . "later") (:form . "Later") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "expand") (:form . "expanded") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "suggestion") (:form . "suggestion") (:end . 48)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 91)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "transposase") (:form . "transposase") (:end . 110)\n  (:start . 99) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 123) (:start . 119)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "catalyze") (:form . "catalyzed") (:end . 133)\n  (:start . 124) (:id . 66))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 148) (:start . 134) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 171)\n  (:start . 160) (:id . 70))\n ((:tag . "VBN") (:stem . "flank") (:form . "flanked") (:end . 179)\n  (:start . 172) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 187) (:start . 183)\n  (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 192) (:start . 188)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 197) (:start . 193)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "precursor") (:form . "precursors") (:end . 208)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSSs") (:end . 216) (:start . 212)\n  (:id . 78))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 218) (:start . 217)\n  (:id . 79))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 220) (:start . 219)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x6.27.1) (:span 73 78)) ((:id . :x6.27.2) (:span 38 48)))\n (:hscopes ((:id . :x6.27.1) (:span 73 216))\n  ((:id . :x6.27.2) (:span 38 216)))\n (:identifiers (:sid . :s6.27) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101767@unknown@formal@none@1@S@This model has received additional support through observations of similar biochemical reactions in transposition and V(D)J recombination [10,11].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "receive") (:form . "received") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NN") (:stem . "support") (:form . "support") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 63)\n  (:start . 51) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 74)\n  (:start . 67) (:id . 51))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "NNS") (:stem . "reaction") (:form . "reactions") (:end . 96)\n  (:start . 87) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 113) (:start . 100) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 117) (:start . 114)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 123)\n  (:start . 118) (:id . 57))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 137) (:start . 124) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 139) (:start . 138)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10,11") (:form . "10,11") (:end . 144)\n  (:start . 139) (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.28) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101768@unknown@formal@none@1@S@Finally, it was demonstrated that RAG1/2 catalyzed transpositions of a DNA segment flanked by RSS12 and RSS23 in vitro [12,13] and in vivo in yeast [14].@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 28)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1/2") (:form . "RAG1/2") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "VBD") (:stem . "catalyze") (:form . "catalyzed") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 65) (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "segment") (:form . "segment") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "VBN") (:stem . "flank") (:form . "flanked") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "rss23") (:form . "RSS23") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 112) (:start . 110)\n  (:id . 60))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "CD") (:stem . "12,13") (:form . "12,13") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 138) (:start . 134)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 151) (:start . 149)\n  (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 152) (:start . 151)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s6.29) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101770@unknown@formal@none@1@S@So far, only one putative instance of such a transposition has been reported [15].@(((:tag . "RB") (:stem . "so") (:form . "So") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 12) (:start . 8)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 25)\n  (:start . 17) (:id . 47))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 34)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 58) (:start . 45) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 62) (:start . 59)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.31) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101771@unknown@formal@none@1@S@However, given the lack of significant structural similarities between RAGs and known TPases, the “RAG transposon” model [9,12,13,16] remained unproven.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "JJ") (:stem . "structural") (:form . "structural") (:end . 49)\n  (:start . 39) (:id . 49))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 62)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 70)\n  (:start . 63) (:id . 51))\n ((:tag . "NNS") (:stem . "rag") (:form . "RAGs") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 92) (:start . 86)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "RAG") (:form . "RAG") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 113)\n  (:start . 103) (:id . 60))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CD") (:stem . "9,12,13,16") (:form . "9,12,13,16") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "remain") (:form . "remained") (:end . 142)\n  (:start . 134) (:id . 66))\n ((:tag . "JJ") (:stem . "unproven") (:form . "unproven") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x6.32.1) (:span 143 151)))\n (:ncues ((:id . :x6.32.2) (:span 19 23)))\n (:hscopes ((:id . :x6.32.1) (:span 94 151)))\n (:nscopes ((:id . :x6.32.2) (:span 19 92)))\n (:identifiers (:sid . :s6.32) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101772@unknown@formal@none@1@S@Here we demonstrate that the RAG1 core and RSSs were derived from a TPase and TIRs encoded by ancient DNA transposons from the Transib superfamily [17].@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "rss") (:form . "RSSs") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 117)\n  (:start . 106) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 134)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 146)\n  (:start . 135) (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.33) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101773@unknown@formal@none@1@S@The Transib superfamily is one of ten superfamilies of DNA transposons detected so far in eukaryotes [17].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 23)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies") (:end . 51)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "eukaryote") (:form . "eukaryotes") (:end . 100)\n  (:start . 90) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.34) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101774@unknown@formal@none@1@S@Like other DNA transposons, Transib transposons exist as autonomous and nonautonomous elements.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 47)\n  (:start . 36) (:id . 48))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 67)\n  (:start . 57) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "nonautonomous") (:form . "nonautonomous")\n  (:end . 85) (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s6.35) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101775@unknown@formal@none@1@S@The autonomous Transib transposons are 3–4 kb long and code for an approximately 700-aa TPase that is not similar to TPases from any other transposon superfamilies.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "CD") (:stem . "3–4") (:form . "3–4") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "kb") (:form . "kb") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "code") (:form . "code") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 80) (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "700-aa") (:form . "700-aa") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 101) (:start . 99)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 123)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 128) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 132) (:start . 129)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 138)\n  (:start . 133) (:id . 65))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 149)\n  (:start . 139) (:id . 66))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies")\n  (:end . 163) (:start . 150) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s6.36) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101776@unknown@formal@none@1@S@Computational analysis of Transib elements, including their numerous insertions into copies of other transposons, demonstrated that Transib transposons are flanked by 5-bp target site duplications (TSDs), which also distinguishes this superfamily from all the others [17].@(((:tag . "JJ") (:stem . "computational") (:form . "Computational")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 22)\n  (:start . 14) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 42)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 59)\n  (:start . 54) (:id . 49))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 68)\n  (:start . 60) (:id . 50))\n ((:tag . "NNS") (:stem . "insertion") (:form . "insertions") (:end . 79)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 84) (:start . 80)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 91) (:start . 85)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 112)\n  (:start . 101) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "demonstrate") (:form . "demonstrated") (:end . 126)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 131) (:start . 127)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 139)\n  (:start . 132) (:id . 60))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 151)\n  (:start . 140) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 155) (:start . 152)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "flank") (:form . "flanked") (:end . 163)\n  (:start . 156) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 166) (:start . 164)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 171) (:start . 167)\n  (:id . 65))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 178)\n  (:start . 172) (:id . 66))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 183) (:start . 179)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "duplication") (:form . "duplications") (:end . 196)\n  (:start . 184) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 198) (:start . 197)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "TSD") (:form . "TSDs") (:end . 202) (:start . 198)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 210)\n  (:start . 205) (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 215) (:start . 211)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "distinguish") (:form . "distinguishes")\n  (:end . 229) (:start . 216) (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 234) (:start . 230)\n  (:id . 76))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 246)\n  (:start . 235) (:id . 77))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 251) (:start . 247)\n  (:id . 78))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 255) (:start . 252)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 259) (:start . 256)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 266)\n  (:start . 260) (:id . 81))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 268) (:start . 267)\n  (:id . 82))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 270) (:start . 268)\n  (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 271) (:start . 270)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 272) (:start . 271)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s6.37) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101777@unknown@formal@none@1@S@Transib transpositions are expected to be catalyzed by the binding of the TPase to TIRs of autonomous and nonautonomous transposons [17].@(((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 22) (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "catalyze") (:form . "catalyzed") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 66)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nonautonomous") (:form . "nonautonomous")\n  (:end . 119) (:start . 106) (:id . 60))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 131)\n  (:start . 120) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 135) (:start . 133)\n  (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 136) (:start . 135)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x6.38.1) (:span 27 35)))\n (:hscopes ((:id . :x6.38.1) (:span 27 131)))\n (:identifiers (:sid . :s6.38) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101778@unknown@formal@none@1@S@As discussed in this paper, in addition to the fruit fly (Drosophila melanogaster) and African malaria mosquito (Anopheles gambiae) genomes, in which Transib transposons were originally discovered, these genes are also present in diverse animals (Table S1), including other species of fruit fly (e.g., Drosophila pseudoobscura, Drosophila willistoni), yellow fever mosquito (Anopheles aegypti), silkworm (Bombyx mori), red flour beetle (Tribolium castaneum), dog hookworm (Ancylostoma caninum), freshwater flatworm (Schmidtea mediterranea), hydra (Hydra magnipapillata), sea urchin (Strongylocentrotus purpuratus), and soybean rust (Phakopsora pachyrhizi).@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "paper") (:form . "paper") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 52) (:start . 47)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 54))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 68)\n  (:start . 58) (:id . 55))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 81)\n  (:start . 69) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "anophele") (:form . "Anopheles") (:end . 122)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "gambiae") (:form . "gambiae") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 68))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 149)\n  (:start . 144) (:id . 69))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 157)\n  (:start . 150) (:id . 70))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 169)\n  (:start . 158) (:id . 71))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 174) (:start . 170)\n  (:id . 72))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 185)\n  (:start . 175) (:id . 73))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 196)\n  (:start . 186) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 75))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 203)\n  (:start . 198) (:id . 76))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 209)\n  (:start . 204) (:id . 77))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 213) (:start . 210)\n  (:id . 78))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 218) (:start . 214)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 226)\n  (:start . 219) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 229) (:start . 227)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 237)\n  (:start . 230) (:id . 82))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 245)\n  (:start . 238) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 247) (:start . 246)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 252)\n  (:start . 247) (:id . 85))\n ((:tag . "NNP") (:stem . "S1") (:form . "S1") (:end . 255) (:start . 253)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 256) (:start . 255)\n  (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 257) (:start . 256)\n  (:id . 88))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 267)\n  (:start . 258) (:id . 89))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 273)\n  (:start . 268) (:id . 90))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 281)\n  (:start . 274) (:id . 91))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 284) (:start . 282)\n  (:id . 92))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 290)\n  (:start . 285) (:id . 93))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 294) (:start . 291)\n  (:id . 94))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 296) (:start . 295)\n  (:id . 95))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 300) (:start . 296)\n  (:id . 96))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 301) (:start . 300)\n  (:id . 97))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 312)\n  (:start . 302) (:id . 98))\n ((:tag . "FW") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 326) (:start . 313) (:id . 99))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 327) (:start . 326)\n  (:id . 100))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 338)\n  (:start . 328) (:id . 101))\n ((:tag . "NNS") (:stem . "willistoni") (:form . "willistoni") (:end . 349)\n  (:start . 339) (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 350) (:start . 349)\n  (:id . 103))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 351) (:start . 350)\n  (:id . 104))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 358)\n  (:start . 352) (:id . 105))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 364)\n  (:start . 359) (:id . 106))\n ((:tag . "NN") (:stem . 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")") (:end . 417) (:start . 416)\n  (:id . 117))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 418) (:start . 417)\n  (:id . 118))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 422) (:start . 419)\n  (:id . 119))\n ((:tag . "NN") (:stem . "flour") (:form . "flour") (:end . 428)\n  (:start . 423) (:id . 120))\n ((:tag . "NN") (:stem . "beetle") (:form . "beetle") (:end . 435)\n  (:start . 429) (:id . 121))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 437) (:start . 436)\n  (:id . 122))\n ((:tag . "NNP") (:stem . "Tribolium") (:form . "Tribolium") (:end . 446)\n  (:start . 437) (:id . 123))\n ((:tag . "NN") (:stem . "castaneum") (:form . "castaneum") (:end . 456)\n  (:start . 447) (:id . 124))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 457) (:start . 456)\n  (:id . 125))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 458) (:start . 457)\n  (:id . 126))\n ((:tag . "NN") (:stem . "dog") (:form . "dog") (:end . 462) (:start . 459)\n  (:id . 127))\n ((:tag . "NN") (:stem . "hookworm") (:form . "hookworm") (:end . 471)\n  (:start . 463) (:id . 128))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 473) (:start . 472)\n  (:id . 129))\n ((:tag . "NNP") (:stem . "Ancylostoma") (:form . "Ancylostoma") (:end . 484)\n  (:start . 473) (:id . 130))\n ((:tag . "NN") (:stem . "caninum") (:form . "caninum") (:end . 492)\n  (:start . 485) (:id . 131))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 493) (:start . 492)\n  (:id . 132))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 494) (:start . 493)\n  (:id . 133))\n ((:tag . "NN") (:stem . "freshwater") (:form . "freshwater") (:end . 505)\n  (:start . 495) (:id . 134))\n ((:tag . "NN") (:stem . "flatworm") (:form . "flatworm") (:end . 514)\n  (:start . 506) (:id . 135))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 516) (:start . 515)\n  (:id . 136))\n ((:tag . "NNP") (:stem . "Schmidtea") (:form . "Schmidtea") (:end . 525)\n  (:start . 516) (:id . 137))\n ((:tag . "NN") (:stem . "mediterranea") (:form . "mediterranea") (:end . 538)\n  (:start . 526) (:id . 138))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 539) (:start . 538)\n  (:id . 139))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 540) (:start . 539)\n  (:id . 140))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 546)\n  (:start . 541) (:id . 141))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 548) (:start . 547)\n  (:id . 142))\n ((:tag . "NN") (:stem . "hydra") (:form . "Hydra") (:end . 553)\n  (:start . 548) (:id . 143))\n ((:tag . "NN") (:stem . "magnipapillata") (:form . "magnipapillata")\n  (:end . 568) (:start . 554) (:id . 144))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 569) (:start . 568)\n  (:id . 145))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 570) (:start . 569)\n  (:id . 146))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 574) (:start . 571)\n  (:id . 147))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 581)\n  (:start . 575) (:id . 148))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 583) (:start . 582)\n  (:id . 149))\n ((:tag . "NNP") (:stem . "Strongylocentrotus") (:form . "Strongylocentrotus")\n  (:end . 601) (:start . 583) (:id . 150))\n ((:tag . "NN") (:stem . "purpuratus") (:form . "purpuratus") (:end . 612)\n  (:start . 602) (:id . 151))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 613) (:start . 612)\n  (:id . 152))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 614) (:start . 613)\n  (:id . 153))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 618) (:start . 615)\n  (:id . 154))\n ((:tag . "NN") (:stem . "soybean") (:form . "soybean") (:end . 626)\n  (:start . 619) (:id . 155))\n ((:tag . "NN") (:stem . "rust") (:form . "rust") (:end . 631) (:start . 627)\n  (:id . 156))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 633) (:start . 632)\n  (:id . 157))\n ((:tag . "NN") (:stem . "phakopsora") (:form . "Phakopsora") (:end . 643)\n  (:start . 633) (:id . 158))\n ((:tag . "NN") (:stem . "pachyrhizi") (:form . "pachyrhizi") (:end . 654)\n  (:start . 644) (:id . 159))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 655) (:start . 654)\n  (:id . 160))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 656) (:start . 655)\n  (:id . 161)))@@@1@120@((:identifiers (:sid . :s6.39) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101780@unknown@formal@none@1@S@Schematic Presentation of Transib transposons, RAG1, RAG2, and RAG1-Like Proteins in Eukaryotes@(((:tag . "JJ") (:stem . "schematic") (:form . "Schematic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Presentation") (:form . "Presentation") (:end . 22)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG2") (:form . "RAG2") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RAG1-Like") (:form . "RAG1-Like") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Eukaryote") (:form . "Eukaryotes") (:end . 95)\n  (:start . 85) (:id . 56)))@@@1@15@((:identifiers (:sid . :s6.41) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101781@unknown@formal@none@1@S@The basic timescale of the evolutionary tree is based on published literature [49–51].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "timescale") (:form . "timescale") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "tree") (:form . "tree") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NN") (:stem . "literature") (:form . "literature") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "49–51") (:form . "49–51") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s6.42) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101782@unknown@formal@none@1@S@Red circles mark species in which Transib TPases were found.@(((:tag . "JJ") (:stem . "red") (:form . "Red") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "circle") (:form . "circles") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "mark") (:form . "mark") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 48) (:start . 42)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.43) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101783@unknown@formal@none@1@S@Gray squares indicate RAG2; orange and blue ellipses show the RAG1 core and RAG1 N-terminal domain, respectively.@(((:tag . "NNP") (:stem . "Gray") (:form . "Gray") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "square") (:form . "squares") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "orange") (:form . "orange") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "ellipsis") (:form . "ellipses") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 59))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 112)\n  (:start . 100) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.44) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101784@unknown@formal@none@1@S@Overall taxonomy, including common and Latin names, is reported on the right side of the figure.@(((:tag . "JJ") (:stem . "overall") (:form . "Overall") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "taxonomy") (:form . "taxonomy") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latin") (:form . "Latin") (:end . 44) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "name") (:form . "names") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "right") (:form . "right") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "side") (:form . "side") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "figure") (:form . "figure") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.45) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101785@unknown@formal@none@1@S@A question mark at the lamprey lineage indicates insufficient sequence data.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "mark") (:form . "mark") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lamprey") (:form . "lamprey") (:end . 30)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "lineage") (:form . "lineage") (:end . 38)\n  (:start . 31) (:id . 48))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 61)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.46) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101786@unknown@formal@none@1@S@A lack of any labels means that the Transib TPase and RAG1/2 are not present in the sequenced portions of the corresponding genomes.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 6) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 13) (:start . 10)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "label") (:form . "labels") (:end . 20)\n  (:start . 14) (:id . 46))\n ((:tag . "VBZ") (:stem . "mean") (:form . "means") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "RAG1/2") (:form . "RAG1/2") (:end . 60)\n  (:start . 54) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 93)\n  (:start . 84) (:id . 59))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 123)\n  (:start . 110) (:id . 63))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 131)\n  (:start . 124) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x6.47.1) (:span 65 68)) ((:id . :x6.47.2) (:span 2 6)))\n (:nscopes ((:id . :x6.47.1) (:span 65 131)) ((:id . :x6.47.2) (:span 2 20)))\n (:identifiers (:sid . :s6.47) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101787@unknown@formal@none@1@S@Among branches lacking Transib TPases, only lamprey and crocodile genomes are not extensively sequenced to date.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "branch") (:form . "branches") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 37) (:start . 31)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "lamprey") (:form . "lamprey") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "crocodile") (:form . "crocodile") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 103)\n  (:start . 94) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x6.48.1) (:span 78 81)) ((:id . :x6.48.2) (:span 15 22)))\n (:nscopes ((:id . :x6.48.1) (:span 44 111)) ((:id . :x6.48.2) (:span 15 37)))\n (:identifiers (:sid . :s6.48) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101788@unknown@formal@none@1@S@In sea anemone, the RAG1 core–like protein is capped by the ring finger motif, which also forms the C-terminus in the RAG1 N-terminal domain.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 42)\n  (:start . 35) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "cap") (:form . "capped") (:end . 52) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 64) (:start . 60)\n  (:id . 54))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 71)\n  (:start . 65) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 89) (:start . 85)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "C-terminus") (:form . "C-terminus") (:end . 110)\n  (:start . 100) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 122) (:start . 118)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 133)\n  (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 140)\n  (:start . 134) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s6.49) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101790@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s6.51) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101791@unknown@formal@none@1@S@Detection of Similarity between Transib TPases and RAG1@(((:tag . "NNP") (:stem . "Detection") (:form . "Detection") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Similarity") (:form . "Similarity") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 39)\n  (:start . 32) (:id . 46))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 46) (:start . 40)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 55) (:start . 51)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.52) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101792@unknown@formal@none@1@S@Using protein sequences of seven known Transib TPases (Transib1 through Transib4 and Transib1_AG through Transib3_AG from D. melanogaster and A. gambiae, respectively) [17] as queries in a standard BLASTP search against all GenBank proteins, we found that the approximately 60-aa C-terminal portion of the Transib2_AG TPase was 35%-38% identical to the C-terminal portion of the RAG1 core (Figure S1).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 53) (:start . 47)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Transib1") (:form . "Transib1") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "Transib4") (:form . "Transib4") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib1_AG") (:form . "Transib1_AG") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNP") (:stem . "Transib3_AG") (:form . "Transib3_AG") (:end . 116)\n  (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 121) (:start . 117)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 137)\n  (:start . 125) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 141) (:start . 138)\n  (:id . 61))\n ((:tag . "NN") (:stem . "a.") (:form . "A.") (:end . 144) (:start . 142)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gambiae") (:form . "gambiae") (:end . 152)\n  (:start . 145) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 166)\n  (:start . 154) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 171) (:start . 169)\n  (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "query") (:form . "queries") (:end . 183)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 186) (:start . 184)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 197)\n  (:start . 189) (:id . 74))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 204)\n  (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 211)\n  (:start . 205) (:id . 76))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 219)\n  (:start . 212) (:id . 77))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 223) (:start . 220)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 231)\n  (:start . 224) (:id . 79))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 240)\n  (:start . 232) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 241) (:start . 240)\n  (:id . 81))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 244) (:start . 242)\n  (:id . 82))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 250)\n  (:start . 245) (:id . 83))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 255) (:start . 251)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 259) (:start . 256)\n  (:id . 85))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 273) (:start . 260) (:id . 86))\n ((:tag . "JJ") (:stem . "60-aa") (:form . "60-aa") (:end . 279)\n  (:start . 274) (:id . 87))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 290)\n  (:start . 280) (:id . 88))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 298)\n  (:start . 291) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 301) (:start . 299)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 305) (:start . 302)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 317)\n  (:start . 306) (:id . 92))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 323)\n  (:start . 318) (:id . 93))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 327) (:start . 324)\n  (:id . 94))\n ((:tag . "CD") (:stem . "35%-38") (:form . "35%-38") (:end . 334)\n  (:start . 328) (:id . 95))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 335) (:start . 334)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 345)\n  (:start . 336) (:id . 97))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 348) (:start . 346)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 352) (:start . 349)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 363)\n  (:start . 353) (:id . 100))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 371)\n  (:start . 364) (:id . 101))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 374) (:start . 372)\n  (:id . 102))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 378) (:start . 375)\n  (:id . 103))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 383) (:start . 379)\n  (:id . 104))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 388) (:start . 384)\n  (:id . 105))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 390) (:start . 389)\n  (:id . 106))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 396)\n  (:start . 390) (:id . 107))\n ((:tag . "NNP") (:stem . "S1") (:form . "S1") (:end . 399) (:start . 397)\n  (:id . 108))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 400) (:start . 399)\n  (:id . 109))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 401) (:start . 400)\n  (:id . 110)))@@@1@69@((:identifiers (:sid . :s6.53) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101793@unknown@formal@none@1@S@However, this similarity was only marginally significant (E = 0.07 where the E-value is an expected number of sequences matching by chance; Table 1).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 24)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "marginally") (:form . "marginally") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0.07") (:form . "0.07") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 72) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "expected") (:form . "expected") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 106)\n  (:start . 100) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "VBG") (:stem . "match") (:form . "matching") (:end . 128)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 138)\n  (:start . 132) (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 145)\n  (:start . 140) (:id . 67))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 149) (:start . 148)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.54) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101794@unknown@formal@none@1@S@In another search against GenBank, using PSI-BLAST [18] (see Materials and Methods) with the Transib2_AG TPase as a query, we found that two unclassified proteins (GenBank gi 30923617 and 30923765; annotated as hypothetical proteins) and RAG1s constituted the only group of any GenBank proteins similar to the Transib2_AG TPase (Table 1).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 70)\n  (:start . 61) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 82)\n  (:start . 75) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 104)\n  (:start . 93) (:id . 61))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 121)\n  (:start . 116) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 125) (:start . 123)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 136) (:start . 132)\n  (:id . 69))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 140) (:start . 137)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "unclassified") (:form . "unclassified") (:end . 153)\n  (:start . 141) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 162)\n  (:start . 154) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 171)\n  (:start . 164) (:id . 74))\n ((:tag . "NNP") (:stem . "gi") (:form . "gi") (:end . 174) (:start . 172)\n  (:id . 75))\n ((:tag . "CD") (:stem . "30923617") (:form . "30923617") (:end . 183)\n  (:start . 175) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 77))\n ((:tag . "CD") (:stem . "30923765") (:form . "30923765") (:end . 196)\n  (:start . 188) (:id . 78))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 197) (:start . 196)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 207)\n  (:start . 198) (:id . 80))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 210) (:start . 208)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 223)\n  (:start . 211) (:id . 82))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 232)\n  (:start . 224) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 237) (:start . 234)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 243)\n  (:start . 238) (:id . 86))\n ((:tag . "VBD") (:stem . "constitute") (:form . "constituted") (:end . 255)\n  (:start . 244) (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 259) (:start . 256)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 264) (:start . 260)\n  (:id . 89))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 270)\n  (:start . 265) (:id . 90))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 273) (:start . 271)\n  (:id . 91))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 277) (:start . 274)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 285)\n  (:start . 278) (:id . 93))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 294)\n  (:start . 286) (:id . 94))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 302)\n  (:start . 295) (:id . 95))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 305) (:start . 303)\n  (:id . 96))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 309) (:start . 306)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 321)\n  (:start . 310) (:id . 98))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 327)\n  (:start . 322) (:id . 99))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 329) (:start . 328)\n  (:id . 100))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 334)\n  (:start . 329) (:id . 101))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 336) (:start . 335)\n  (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 337) (:start . 336)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 338) (:start . 337)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s6.55) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101795@unknown@formal@none@1@S@The statistical significance of similarity between the TPase and RAG1s was measured by Ei = 0.025, where Ei is the E-value threshold for the first inclusion of RAG1 sequences into the PSI-BLAST iterations [18] (Materials and Methods).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "statistical") (:form . "statistical") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 45))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 50)\n  (:start . 43) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 70) (:start . 65)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "CD") (:stem . "0.025") (:form . "0.025") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 104)\n  (:start . 99) (:id . 59))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 107) (:start . 105)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "e-value") (:form . "E-value") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "inclusion") (:form . "inclusion") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 174)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 193)\n  (:start . 184) (:id . 74))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 204)\n  (:start . 194) (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 206) (:start . 205)\n  (:id . 76))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 208) (:start . 206)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 209) (:start . 208)\n  (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 79))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 220)\n  (:start . 211) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 81))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 232)\n  (:start . 225) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s6.56) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101796@unknown@formal@none@1@S@The observed improvement in significance of the Transib/RAG1 similarity (from E = 0.07 in BLASTP to Ei = 0.025 in PSI-BLAST; Table 1) was due to the fact that both 151-aa and 123-aa hypothetical GenBank proteins were apparent remnants of Transib TPases (approximately 40% identity to the Transib2_AG TPase, E < 10-10 in BLASTP).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "improvement") (:form . "improvement") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 40)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "transib/rag1") (:form . "Transib/RAG1") (:end . 60)\n  (:start . 48) (:id . 49))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 71)\n  (:start . 61) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CD") (:stem . "0.07") (:form . "0.07") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CD") (:stem . "0.025") (:form . "0.025") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 123)\n  (:start . 114) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 130)\n  (:start . 125) (:id . 65))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 141) (:start . 138)\n  (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 144) (:start . 142)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 71))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 153) (:start . 149)\n  (:id . 72))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 73))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 163) (:start . 159)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "151-aa") (:form . "151-aa") (:end . 170)\n  (:start . 164) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "123-aa") (:form . "123-aa") (:end . 181)\n  (:start . 175) (:id . 77))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 194)\n  (:start . 182) (:id . 78))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 202)\n  (:start . 195) (:id . 79))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 211)\n  (:start . 203) (:id . 80))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 216) (:start . 212)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 225)\n  (:start . 217) (:id . 82))\n ((:tag . "NNS") (:stem . "remnant") (:form . "remnants") (:end . 234)\n  (:start . 226) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 237) (:start . 235)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 245)\n  (:start . 238) (:id . 85))\n ((:tag . "NNPS") (:stem . "TPas") (:form . "TPases") (:end . 252)\n  (:start . 246) (:id . 86))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 254) (:start . 253)\n  (:id . 87))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 267) (:start . 254) (:id . 88))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 270) (:start . 268)\n  (:id . 89))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 271) (:start . 270)\n  (:id . 90))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 280)\n  (:start . 272) (:id . 91))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 283) (:start . 281)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 287) (:start . 284)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 299)\n  (:start . 288) (:id . 94))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 305)\n  (:start . 300) (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 306) (:start . 305)\n  (:id . 96))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 308) (:start . 307)\n  (:id . 97))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 310) (:start . 309)\n  (:id . 98))\n ((:tag . "CD") (:stem . "10-10") (:form . "10-10") (:end . 316)\n  (:start . 311) (:id . 99))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 319) (:start . 317)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 326)\n  (:start . 320) (:id . 101))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 327) (:start . 326)\n  (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 328) (:start . 327)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s6.57) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101797@unknown@formal@none@1@S@The RAG1 proteins appeared to be more similar to the position-specific scoring matrix (PSSM) created by PSI-BLAST based on multiple alignment of the Transib2_AG TPase and two Transib TPase-like proteins, than to the solo Transib2_AG TPase in the BLASTP search.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "position-specific") (:form . "position-specific")\n  (:end . 70) (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "scoring") (:form . "scoring") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 119)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 160)\n  (:start . 149) (:id . 67))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 166)\n  (:start . 161) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 182)\n  (:start . 175) (:id . 71))\n ((:tag . "JJ") (:stem . "tpase-like") (:form . "TPase-like") (:end . 193)\n  (:start . 183) (:id . 72))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 202)\n  (:start . 194) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 74))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 208) (:start . 204)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 211) (:start . 209)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 77))\n ((:tag . "NN") (:stem . "solo") (:form . "solo") (:end . 220) (:start . 216)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 232)\n  (:start . 221) (:id . 79))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 238)\n  (:start . 233) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 241) (:start . 239)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 245) (:start . 242)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 252)\n  (:start . 246) (:id . 83))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 259)\n  (:start . 253) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x6.58.1) (:span 18 26)))\n (:hscopes ((:id . :x6.58.1) (:span 0 259)))\n (:identifiers (:sid . :s6.58) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101798@unknown@formal@none@1@S@Given the latter observation, we decided to improve the quality of the PSSM constructed by PSI-BLAST for different Transib TPase sequences.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "decide") (:form . "decided") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "improve") (:form . "improve") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "quality") (:form . "quality") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 87)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 122)\n  (:start . 115) (:id . 61))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 138)\n  (:start . 129) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.59) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101800@unknown@formal@none@1@S@As a result, Ei-values for matches of RAG1s to a new PSSM based on alignment of nine Transib TPases (the two GenBank TPase-like proteins plus seven added TPases) noticeably dropped in comparison with the Ei-values obtained for the PSSM constructed in the previous step based on alignment of the three TPases (Table 1).@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 22)\n  (:start . 13) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "rag1") (:form . "RAG1s") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 57) (:start . 53)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 66) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 76)\n  (:start . 67) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 84) (:start . 80)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 92)\n  (:start . 85) (:id . 60))\n ((:tag . "NNPS") (:stem . "TPas") (:form . "TPases") (:end . 99)\n  (:start . 93) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 116)\n  (:start . 109) (:id . 65))\n ((:tag . "JJ") (:stem . "tpase-like") (:form . "TPase-like") (:end . 127)\n  (:start . 117) (:id . 66))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 136)\n  (:start . 128) (:id . 67))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 141) (:start . 137)\n  (:id . 68))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 147)\n  (:start . 142) (:id . 69))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 153) (:start . 148)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 160)\n  (:start . 154) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "RB") (:stem . "noticeably") (:form . "noticeably") (:end . 172)\n  (:start . 162) (:id . 73))\n ((:tag . "VBD") (:stem . "drop") (:form . "dropped") (:end . 180)\n  (:start . 173) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 75))\n ((:tag . "NN") (:stem . "comparison") (:form . "comparison") (:end . 194)\n  (:start . 184) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 199) (:start . 195)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 213)\n  (:start . 204) (:id . 79))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 222)\n  (:start . 214) (:id . 80))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 226) (:start . 223)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 230) (:start . 227)\n  (:id . 82))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 235) (:start . 231)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 247)\n  (:start . 236) (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 250) (:start . 248)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 254) (:start . 251)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 263)\n  (:start . 255) (:id . 87))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 268) (:start . 264)\n  (:id . 88))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 274)\n  (:start . 269) (:id . 89))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 277) (:start . 275)\n  (:id . 90))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 287)\n  (:start . 278) (:id . 91))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 290) (:start . 288)\n  (:id . 92))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 294) (:start . 291)\n  (:id . 93))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 300)\n  (:start . 295) (:id . 94))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 307)\n  (:start . 301) (:id . 95))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 309) (:start . 308)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 314)\n  (:start . 309) (:id . 97))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 316) (:start . 315)\n  (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 317) (:start . 316)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 318) (:start . 317)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s6.61) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101801@unknown@formal@none@1@S@To support the observation that Ei-values of matches between RAG1s and the Transib TPase PSSM decrease as the number of TPase sequences used for construction of the PSSM increases, we identified six new Transib TPases (Transib5, Transib3_DP, Transib4_DP, Transib1_AA, Transib2_AA, Transib3_AA; Figure S2).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "support") (:form . "support") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 88) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 125)\n  (:start . 120) (:id . 62))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 135)\n  (:start . 126) (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 140) (:start . 136)\n  (:id . 64))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 144) (:start . 141)\n  (:id . 65))\n ((:tag . "NN") (:stem . "construction") (:form . "construction") (:end . 157)\n  (:start . 145) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 183) (:start . 181)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 194)\n  (:start . 184) (:id . 73))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 198) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 202) (:start . 199)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 210)\n  (:start . 203) (:id . 76))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 217)\n  (:start . 211) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Transib5") (:form . "Transib5") (:end . 227)\n  (:start . 219) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Transib3_DP") (:form . "Transib3_DP") (:end . 240)\n  (:start . 229) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 241) (:start . 240)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Transib4_DP") (:form . "Transib4_DP") (:end . 253)\n  (:start . 242) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 254) (:start . 253)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "Transib1_AA") (:form . "Transib1_AA") (:end . 266)\n  (:start . 255) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 267) (:start . 266)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Transib2_AA") (:form . "Transib2_AA") (:end . 279)\n  (:start . 268) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 280) (:start . 279)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "Transib3_AA") (:form . "Transib3_AA") (:end . 292)\n  (:start . 281) (:id . 89))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 293) (:start . 292)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 300)\n  (:start . 294) (:id . 91))\n ((:tag . "NNP") (:stem . "S2") (:form . "S2") (:end . 303) (:start . 301)\n  (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 304) (:start . 303)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 305) (:start . 304)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s6.62) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101802@unknown@formal@none@1@S@During the next step of the PSI-BLAST analysis, the original GenBank set was combined with 13 Transib TPases.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 57))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.63) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101803@unknown@formal@none@1@S@Again, Ei-values of matches between RAG1s and the new PSSM derived from multiple alignment of 15 Transib TPases (the two GenBank proteins plus all our TPases) were much smaller (approximately 10-6–10-3; Table 1) than those obtained based on the PSSM constructed from the nine TPases at the preceding step (approximately 10-3–10-2).@(((:tag . "RB") (:stem . "again") (:form . "Again") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 16)\n  (:start . 7) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 90)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . "NNPS") (:stem . "TPas") (:form . "TPases") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 128)\n  (:start . 121) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 137)\n  (:start . 129) (:id . 65))\n ((:tag . "CC") (:stem . "plus") (:form . "plus") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 150) (:start . 147)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 168) (:start . 164)\n  (:id . 72))\n ((:tag . "JJR") (:stem . "small") (:form . "smaller") (:end . 176)\n  (:start . 169) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 74))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 191) (:start . 178) (:id . 75))\n ((:tag . "CD") (:stem . "10-6–10-3") (:form . "10-6–10-3") (:end . 201)\n  (:start . 192) (:id . 76))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 202) (:start . 201)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 211) (:start . 210)\n  (:id . 80))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 216) (:start . 212)\n  (:id . 81))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 222)\n  (:start . 217) (:id . 82))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 231)\n  (:start . 223) (:id . 83))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 237)\n  (:start . 232) (:id . 84))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 240) (:start . 238)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 244) (:start . 241)\n  (:id . 86))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 249) (:start . 245)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 261)\n  (:start . 250) (:id . 88))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 266) (:start . 262)\n  (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 270) (:start . 267)\n  (:id . 90))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 275) (:start . 271)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 282)\n  (:start . 276) (:id . 92))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 285) (:start . 283)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 289) (:start . 286)\n  (:id . 94))\n ((:tag . "VBG") (:stem . "precede") (:form . "preceding") (:end . 299)\n  (:start . 290) (:id . 95))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 304) (:start . 300)\n  (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 306) (:start . 305)\n  (:id . 97))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 319) (:start . 306) (:id . 98))\n ((:tag . "CD") (:stem . "10-3–10-2") (:form . "10-3–10-2") (:end . 329)\n  (:start . 320) (:id . 99))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 330) (:start . 329)\n  (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 331) (:start . 330)\n  (:id . 101)))@@@1@60@((:identifiers (:sid . :s6.64) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101804@unknown@formal@none@1@S@In the final step, we identified one more set of five new Transib TPases (Transib1_DP, Transib2_DP, Transib4_AA, Transib5_AA, and Transib1_SP).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 21) (:start . 19)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 32)\n  (:start . 22) (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 52))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 53) (:start . 49)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 65)\n  (:start . 58) (:id . 55))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 72) (:start . 66)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Transib1_DP") (:form . "Transib1_DP") (:end . 85)\n  (:start . 74) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Transib2_DP") (:form . "Transib2_DP") (:end . 98)\n  (:start . 87) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Transib4_AA") (:form . "Transib4_AA") (:end . 111)\n  (:start . 100) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Transib5_AA") (:form . "Transib5_AA") (:end . 124)\n  (:start . 113) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Transib1_SP") (:form . "Transib1_SP") (:end . 141)\n  (:start . 130) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.65) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101805@unknown@formal@none@1@S@When all 18 TPases were combined with the original GenBank set, the Ei values of matches between RAG1s and the Transib PSSM dropped significantly further (10-9–10-4; Table 1).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 18) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 32)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 88)\n  (:start . 81) (:id . 58))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 96)\n  (:start . 89) (:id . 59))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 102) (:start . 97)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 118)\n  (:start . 111) (:id . 63))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 123) (:start . 119)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "drop") (:form . "dropped") (:end . 131)\n  (:start . 124) (:id . 65))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 145) (:start . 132) (:id . 66))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 153)\n  (:start . 146) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 155) (:start . 154)\n  (:id . 68))\n ((:tag . "CD") (:stem . "10-9–10-4") (:form . "10-9–10-4") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 171)\n  (:start . 166) (:id . 71))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 173) (:start . 172)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.66) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101806@unknown@formal@none@1@S@During the final revision of this manuscript, we identified an intermediate RAG1-like sequence in Hydra magnipapillata, called RAG1L_HM, which is significantly similar to both RAG1 and Transib TPase, as shown later.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "revision") (:form . "revision") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "manuscript") (:form . "manuscript") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 75)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 85)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 94)\n  (:start . 86) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Hydra") (:form . "Hydra") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "magnipapillata") (:form . "magnipapillata")\n  (:end . 118) (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NNP") (:stem . "RAG1L_HM") (:form . "RAG1L_HM") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 145) (:start . 143)\n  (:id . 64))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 159) (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 167)\n  (:start . 160) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 175) (:start . 171)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 180) (:start . 176)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 192)\n  (:start . 185) (:id . 71))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 198)\n  (:start . 193) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 73))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 202) (:start . 200)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 208)\n  (:start . 203) (:id . 75))\n ((:tag . "RB") (:stem . "later") (:form . "later") (:end . 214)\n  (:start . 209) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s6.67) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101807@unknown@formal@none@1@S@This direct result represents an independent validation of our analysis.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "validation") (:form . "validation") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 71)\n  (:start . 63) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.68) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101808@unknown@formal@none@1@S@The PSI-BLAST PSSM of Transib TPases approximates conservation/variability of the Transib TPase consensus sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 29)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 36) (:start . 30)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "approximate") (:form . "approximates") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "conservation/variability")\n  (:form . "conservation/variability") (:end . 74) (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 89)\n  (:start . 82) (:id . 52))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 95) (:start . 90)\n  (:id . 53))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 105)\n  (:start . 96) (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 114)\n  (:start . 106) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s6.69) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101810@unknown@formal@none@1@S@The RAG1 Ei values decreased as the number of Transib TPases used for the PSSM construction increased due to the fact that RAG1 evolved from a Transib TPase.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 60) (:start . 54)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 69) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 78) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "construction") (:form . "construction") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "VBD") (:stem . "increase") (:form . "increased") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 135)\n  (:start . 128) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 150)\n  (:start . 143) (:id . 68))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.71) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101811@unknown@formal@none@1@S@In all cases, the E values obtained after several rounds of iterations were less than 10-20 at the point of convergence.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 46))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 26)\n  (:start . 20) (:id . 48))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 35)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 41) (:start . 36)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "round") (:form . "rounds") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 85) (:start . 81)\n  (:id . 57))\n ((:tag . "CD") (:stem . "10-20") (:form . "10-20") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 104) (:start . 99)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "convergence") (:form . "convergence") (:end . 119)\n  (:start . 108) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.72) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101812@unknown@formal@none@1@S@Nearly the entire sequences of several Transib TPases, excluding their 100–140-aa N-terminal domains, converged with an approximately 600-aa portion of RAG1 defined by positions approximately 360–1010 (Figure S3).@(((:tag . "RB") (:stem . "nearly") (:form . "Nearly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 53) (:start . 47)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 70)\n  (:start . 65) (:id . 52))\n ((:tag . "JJ") (:stem . "100–140-aa") (:form . "100–140-aa") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 100)\n  (:start . 93) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "converge") (:form . "converged") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 133) (:start . 120) (:id . 60))\n ((:tag . "JJ") (:stem . "600-aa") (:form . "600-aa") (:end . 140)\n  (:start . 134) (:id . 61))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 148)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 156) (:start . 152)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 164)\n  (:start . 157) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 177)\n  (:start . 168) (:id . 67))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 191) (:start . 178) (:id . 68))\n ((:tag . "CD") (:stem . "360–1010") (:form . "360–1010") (:end . 200)\n  (:start . 192) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 208)\n  (:start . 202) (:id . 71))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 211) (:start . 209)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.73) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101813@unknown@formal@none@1@S@This portion of RAG1 corresponds to the “RAG1 core,” hereafter numbered relative to human RAG1 (residues 387–1011), which along with RAG2 is known to be sufficient to perform V(D)J cleavage even after deletions of the 383-aa N-terminal and 32-aa C-terminal portions of RAG1 [19,20].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 32)\n  (:start . 21) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "RAG1") (:form . "RAG1") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "”") (:form . "”") (:end . 52) (:start . 51)\n  (:id . 53))\n ((:tag . "RB") (:stem . "hereafter") (:form . "hereafter") (:end . 62)\n  (:start . 53) (:id . 54))\n ((:tag . "VBN") (:stem . "number") (:form . "numbered") (:end . 71)\n  (:start . 63) (:id . 55))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 94) (:start . 90)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "CD") (:stem . "387–1011") (:form . "387–1011") (:end . 113)\n  (:start . 105) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 127)\n  (:start . 122) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 132) (:start . 128)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 137) (:start . 133)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 146)\n  (:start . 141) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 149) (:start . 147)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 152) (:start . 150)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 163)\n  (:start . 153) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 166) (:start . 164)\n  (:id . 74))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 174)\n  (:start . 167) (:id . 75))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 180)\n  (:start . 175) (:id . 76))\n ((:tag . "NN") (:stem . "cleavage") (:form . "cleavage") (:end . 189)\n  (:start . 181) (:id . 77))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 194) (:start . 190)\n  (:id . 78))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 200)\n  (:start . 195) (:id . 79))\n ((:tag . "NNS") (:stem . "deletion") (:form . "deletions") (:end . 210)\n  (:start . 201) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "383-aa") (:form . "383-aa") (:end . 224)\n  (:start . 218) (:id . 83))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 235)\n  (:start . 225) (:id . 84))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "32-aa") (:form . "32-aa") (:end . 245)\n  (:start . 240) (:id . 86))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 256)\n  (:start . 246) (:id . 87))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 265)\n  (:start . 257) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 268) (:start . 266)\n  (:id . 89))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 273) (:start . 269)\n  (:id . 90))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 275) (:start . 274)\n  (:id . 91))\n ((:tag . "CD") (:stem . "19,20") (:form . "19,20") (:end . 280)\n  (:start . 275) (:id . 92))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 281) (:start . 280)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 282) (:start . 281)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s6.74) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101814@unknown@formal@none@1@S@During studies reported here, we identified 11 additional new families of Transib transposons and TPases (see Figure S2) that are well preserved in the genomes of fruit flies (Transib5 in D. melanogaster; and Transib1_DP, Transib2_DP, Transib3_DP, and Transib4_DP in D. pseudoobscura), mosquitoes (Transib1_AA, Transib2_AA, Transib3_AA, Transib4_AA, and Transib5_AA from A. aegypti) and sea urchin (Transib1_SP).@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 93)\n  (:start . 82) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 104)\n  (:start . 98) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 116)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 134) (:start . 130)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "preserve") (:form . "preserved") (:end . 144)\n  (:start . 135) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 174) (:start . 169)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Transib5") (:form . "Transib5") (:end . 184)\n  (:start . 176) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 190) (:start . 188)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 203) (:start . 191) (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 204) (:start . 203)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 208) (:start . 205)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Transib1_DP") (:form . "Transib1_DP") (:end . 220)\n  (:start . 209) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 221) (:start . 220)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Transib2_DP") (:form . "Transib2_DP") (:end . 233)\n  (:start . 222) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 234) (:start . 233)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "Transib3_DP") (:form . "Transib3_DP") (:end . 246)\n  (:start . 235) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 251) (:start . 248)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Transib4_DP") (:form . "Transib4_DP") (:end . 263)\n  (:start . 252) (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 266) (:start . 264)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 269) (:start . 267)\n  (:id . 89))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 283) (:start . 270) (:id . 90))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 284) (:start . 283)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 285) (:start . 284)\n  (:id . 92))\n ((:tag . "NNS") (:stem . "mosquito") (:form . "mosquitoes") (:end . 296)\n  (:start . 286) (:id . 93))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 298) (:start . 297)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "Transib1_AA") (:form . "Transib1_AA") (:end . 309)\n  (:start . 298) (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 310) (:start . 309)\n  (:id . 96))\n ((:tag . "NNP") (:stem . "Transib2_AA") (:form . "Transib2_AA") (:end . 322)\n  (:start . 311) (:id . 97))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 323) (:start . 322)\n  (:id . 98))\n ((:tag . "NNP") (:stem . "Transib3_AA") (:form . "Transib3_AA") (:end . 335)\n  (:start . 324) (:id . 99))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 336) (:start . 335)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "Transib4_AA") (:form . "Transib4_AA") (:end . 348)\n  (:start . 337) (:id . 101))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 349) (:start . 348)\n  (:id . 102))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 353) (:start . 350)\n  (:id . 103))\n ((:tag . "NNP") (:stem . "Transib5_AA") (:form . "Transib5_AA") (:end . 365)\n  (:start . 354) (:id . 104))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 370) (:start . 366)\n  (:id . 105))\n ((:tag . "NNP") (:stem . "A.") (:form . "A.") (:end . 373) (:start . 371)\n  (:id . 106))\n ((:tag . "NN") (:stem . "aegypti") (:form . "aegypti") (:end . 381)\n  (:start . 374) (:id . 107))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 382) (:start . 381)\n  (:id . 108))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 386) (:start . 383)\n  (:id . 109))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 390) (:start . 387)\n  (:id . 110))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 397)\n  (:start . 391) (:id . 111))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 399) (:start . 398)\n  (:id . 112))\n ((:tag . "NNP") (:stem . "Transib1_SP") (:form . "Transib1_SP") (:end . 410)\n  (:start . 399) (:id . 113))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 411) (:start . 410)\n  (:id . 114))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 412) (:start . 411)\n  (:id . 115)))@@@1@74@((:identifiers (:sid . :s6.75) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101815@unknown@formal@none@1@S@Transib1_SP is the first Transib transposon identified outside of insect genomes.@(((:tag . "NNP") (:stem . "Transib1_SP") (:form . "Transib1_SP") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "JJ") (:stem . "outside") (:form . "outside") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NN") (:stem . "insect") (:form . "insect") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.76) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101816@unknown@formal@none@1@S@A well-preserved 4132-bp Transib1_SP element (contig 7839, positions 376–4506) is flanked by a 5-bp CGGCG TSD, and it encodes a 676-aa TPase (two exons) that is most similar to the Transib2 TPase (34% identity).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "well-preserved") (:form . "well-preserved")\n  (:end . 16) (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "4132-bp") (:form . "4132-bp") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "Transib1_SP") (:form . "Transib1_SP") (:end . 36)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 44)\n  (:start . 37) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 47))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "CD") (:stem . "7839") (:form . "7839") (:end . 57) (:start . 53)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "CD") (:stem . "376–4506") (:form . "376–4506") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 78) (:start . 77)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "flank") (:form . "flanked") (:end . 89)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 99) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "CGGCG") (:form . "CGGCG") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "TSD") (:form . "TSD") (:end . 109) (:start . 106)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 125)\n  (:start . 118) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "676-aa") (:form . "676-aa") (:end . 134)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 140)\n  (:start . 135) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 145) (:start . 142)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 151)\n  (:start . 146) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 157) (:start . 153)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 160) (:start . 158)\n  (:id . 73))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 165) (:start . 161)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 173)\n  (:start . 166) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "Transib2") (:form . "Transib2") (:end . 189)\n  (:start . 181) (:id . 78))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 195)\n  (:start . 190) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 80))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 199) (:start . 197)\n  (:id . 81))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 200) (:start . 199)\n  (:id . 82))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 209)\n  (:start . 201) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s6.77) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101817@unknown@formal@none@1@S@Based on the currently available sequence data, we also reconstructed portions of TPases that were missed in previous studies [17] (Materials and Methods; see Figure S2).@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "reconstruct") (:form . "reconstructed") (:end . 69)\n  (:start . 56) (:id . 52))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 78)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 88) (:start . 82)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "miss") (:form . "missed") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 117)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 141)\n  (:start . 132) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 153)\n  (:start . 146) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 168) (:start . 166)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 169) (:start . 168)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.78) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101818@unknown@formal@none@1@S@Using the Transib1_SP TPase as a query in TBLASTN searches against all GenBank sections (NR, HTGs, WGS, dbGSS, dbEST, dbSTS, and Trace Archives) we also found diverse Transib TPases in silkworm, red flour beetle, dog hookworm, freshwater flatworm, soybean rust, and hydra (Table S1).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Transib1_SP") (:form . "Transib1_SP") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TBLASTN") (:form . "TBLASTN") (:end . 49)\n  (:start . 42) (:id . 50))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 87)\n  (:start . 79) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "NR") (:form . "NR") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HTGs") (:form . "HTGs") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "WGS") (:form . "WGS") (:end . 102) (:start . 99)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "NN") (:stem . "dbgss") (:form . "dbGSS") (:end . 109)\n  (:start . 104) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dbest") (:form . "dbEST") (:end . 116)\n  (:start . 111) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 66))\n ((:tag . "NN") (:stem . "dbsts") (:form . "dbSTS") (:end . 123)\n  (:start . 118) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 134)\n  (:start . 129) (:id . 70))\n ((:tag . "NNPS") (:stem . "Archives") (:form . "Archives") (:end . 143)\n  (:start . 135) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 147) (:start . 145)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 152) (:start . 148)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 158)\n  (:start . 153) (:id . 75))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 166)\n  (:start . 159) (:id . 76))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 174)\n  (:start . 167) (:id . 77))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 181)\n  (:start . 175) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 184) (:start . 182)\n  (:id . 79))\n ((:tag . "NN") (:stem . "silkworm") (:form . "silkworm") (:end . 193)\n  (:start . 185) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 198) (:start . 195)\n  (:id . 82))\n ((:tag . "NN") (:stem . "flour") (:form . "flour") (:end . 204)\n  (:start . 199) (:id . 83))\n ((:tag . "NN") (:stem . "beetle") (:form . "beetle") (:end . 211)\n  (:start . 205) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 212) (:start . 211)\n  (:id . 85))\n ((:tag . "NN") (:stem . "dog") (:form . "dog") (:end . 216) (:start . 213)\n  (:id . 86))\n ((:tag . "NN") (:stem . "hookworm") (:form . "hookworm") (:end . 225)\n  (:start . 217) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 226) (:start . 225)\n  (:id . 88))\n ((:tag . "NN") (:stem . "freshwater") (:form . "freshwater") (:end . 237)\n  (:start . 227) (:id . 89))\n ((:tag . "NN") (:stem . "flatworm") (:form . "flatworm") (:end . 246)\n  (:start . 238) (:id . 90))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 247) (:start . 246)\n  (:id . 91))\n ((:tag . "NN") (:stem . "soybean") (:form . "soybean") (:end . 255)\n  (:start . 248) (:id . 92))\n ((:tag . "NN") (:stem . "rust") (:form . "rust") (:end . 260) (:start . 256)\n  (:id . 93))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 261) (:start . 260)\n  (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 265) (:start . 262)\n  (:id . 95))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 271)\n  (:start . 266) (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 273) (:start . 272)\n  (:id . 97))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 278)\n  (:start . 273) (:id . 98))\n ((:tag . "NNP") (:stem . "S1") (:form . "S1") (:end . 281) (:start . 279)\n  (:id . 99))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 282) (:start . 281)\n  (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 101)))@@@1@60@((:identifiers (:sid . :s6.79) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101820@unknown@formal@none@1@S@The observed patchy distribution could be caused by horizontal transfers and extinctions of Transib transposons in eukaryotic species.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "patchy") (:form . "patchy") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 38) (:start . 33)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "horizontal") (:form . "horizontal") (:end . 62)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "transfer") (:form . "transfers") (:end . 72)\n  (:start . 63) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "extinction") (:form . "extinctions") (:end . 88)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 99)\n  (:start . 92) (:id . 55))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 111)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 125)\n  (:start . 115) (:id . 58))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 133)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x6.81.1) (:span 33 38)))\n (:hscopes ((:id . :x6.81.1) (:span 0 133)))\n (:identifiers (:sid . :s6.81) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101821@unknown@formal@none@1@S@Significance of Similarities between the Transib TPases and RAG1 Core@(((:tag . "NN") (:stem . "significance") (:form . "Significance") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "similarity") (:form . "Similarities") (:end . 28)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 36)\n  (:start . 29) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 55) (:start . 49)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Core") (:form . "Core") (:end . 69) (:start . 65)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.82) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5101822@unknown@formal@none@1@S@The first column lists all 18 Transib TPases used as queries in our analysis, and the shaded areas indicate those added to the original set of all GenBank proteins in subsequent PSI-BLAST searches.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "list") (:form . "lists") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 44) (:start . 38)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "query") (:form . "queries") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "shaded") (:form . "shaded") (:end . 92)\n  (:start . 86) (:id . 59))\n ((:tag . "NNS") (:stem . "area") (:form . "areas") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 113)\n  (:start . 108) (:id . 62))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 119) (:start . 114)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 135)\n  (:start . 127) (:id . 66))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 154)\n  (:start . 147) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 163)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "subsequent") (:form . "subsequent") (:end . 177)\n  (:start . 167) (:id . 73))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 187)\n  (:start . 178) (:id . 74))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 196)\n  (:start . 188) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.83) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101823@unknown@formal@none@1@S@The original GenBank set included two incomplete Transib TPase-like proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "JJ") (:stem . "tpase-like") (:form . "TPase-like") (:end . 67)\n  (:start . 57) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.84) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101824@unknown@formal@none@1@S@Column 2 lists E-values of best matches between RAG1s and Transib TPases detected in BLASTP searches against the original GenBank set.@(((:tag . "NN") (:stem . "column") (:form . "Column") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "list") (:form . "lists") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "e-value") (:form . "E-values") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 47)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 72) (:start . 66)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 91)\n  (:start . 85) (:id . 56))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 100)\n  (:start . 92) (:id . 57))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 129)\n  (:start . 122) (:id . 61))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.85) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101825@unknown@formal@none@1@S@Column 3 reports Ei-values of best matches between RAG1s and a PSSM derived from the chosen query sequence and the two GenBank TPase-like proteins in PSI-BLAST searches against the original set of all GenBank proteins (see Materials and Methods).@(((:tag . "NN") (:stem . "column") (:form . "Column") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 56) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "choose") (:form . "chosen") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 126)\n  (:start . 119) (:id . 63))\n ((:tag . "JJ") (:stem . "tpase-like") (:form . "TPase-like") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 168)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 176)\n  (:start . 169) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 189)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 193) (:start . 190)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 196) (:start . 194)\n  (:id . 73))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 208)\n  (:start . 201) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 217)\n  (:start . 209) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 77))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 232)\n  (:start . 223) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 80))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 244)\n  (:start . 237) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 245) (:start . 244)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s6.86) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101826@unknown@formal@none@1@S@Columns 4–6 report the Ei-values for best matches between RAG1s and a Transib-derived PSSM after adding 7, 13, and 18 Transib TPases to the GenBank set, respectively.@(((:tag . "NNS") (:stem . "column") (:form . "Columns") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "CD") (:stem . "4–6") (:form . "4–6") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1s") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transib-derived") (:form . "Transib-derived")\n  (:end . 85) (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "add") (:form . "adding") (:end . 103) (:start . 97)\n  (:id . 57))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 117) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 125)\n  (:start . 118) (:id . 64))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 132)\n  (:start . 126) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 151) (:start . 148)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 70))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 165)\n  (:start . 153) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s6.87) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101827@unknown@formal@none@1@S@The numbers of the PSI-BLAST iterations after which the entire RAG1 core significantly aligned with the TPases are indicated in parentheses.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 51) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 86) (:start . 73) (:id . 54))\n ((:tag . "VBN") (:stem . "align") (:form . "aligned") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 124)\n  (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "parenthesis") (:form . "parentheses") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.88) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101828@unknown@formal@none@1@S@Ei-values greater than 1 are indicated by dashes.@(((:tag . "NNS") (:stem . "ei-value") (:form . "Ei-values") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJR") (:stem . "great") (:form . "greater") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "dash") (:form . "dashes") (:end . 48) (:start . 42)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.89) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101830@unknown@formal@none@1@S@Diversity of the Transib TPases and RAG1 Core–Like Proteins in Animals@(((:tag . "NN") (:stem . "diversity") (:form . "Diversity") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 31) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Core–Like") (:form . "Core–Like") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "Animal") (:form . "Animals") (:end . 70)\n  (:start . 63) (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.91) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101831@unknown@formal@none@1@S@The phylogenetic tree was obtained by using the neighbor-joining algorithm implemented in MEGA [44].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "phylogenetic") (:form . "phylogenetic") (:end . 16)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "tree") (:form . "tree") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "neighbor-joining") (:form . "neighbor-joining")\n  (:end . 64) (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "algorithm") (:form . "algorithm") (:end . 74)\n  (:start . 65) (:id . 51))\n ((:tag . "VBN") (:stem . "implement") (:form . "implemented") (:end . 86)\n  (:start . 75) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "MEGA") (:form . "MEGA") (:end . 94) (:start . 90)\n  (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 96) (:start . 95)\n  (:id . 55))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.92) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101832@unknown@formal@none@1@S@Evolutionary distance for each pair of protein sequences was measured as the proportion of aa sites at which the two sequences were different.@(((:tag . "JJ") (:stem . "evolutionary") (:form . "Evolutionary") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "distance") (:form . "distance") (:end . 21)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pair") (:form . "pair") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "measure") (:form . "measured") (:end . 69)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "proportion") (:form . "proportion") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 102) (:start . 100)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 131) (:start . 127)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 141)\n  (:start . 132) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s6.93) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101833@unknown@formal@none@1@S@Its scale is shown by the horizontal bar.@(((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "horizontal") (:form . "horizontal") (:end . 36)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 41) (:start . 40)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.94) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101834@unknown@formal@none@1@S@Bootstrap values higher than 60% are reported at the corresponding nodes.@(((:tag . "NNP") (:stem . "Bootstrap") (:form . "Bootstrap") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 23) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 66)\n  (:start . 53) (:id . 52))\n ((:tag . "NNS") (:stem . "node") (:form . "nodes") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 73) (:start . 72)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.95) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101835@unknown@formal@none@1@S@Species abbreviations are as follows: AA, yellow fever mosquito; AG, African malaria mosquito; BF, lancelet; CL, bull shark; DP, D. pseudoobscura fruit fly; FR, fugu fish; HM, hydra; HS, human; NV, starlet sea anemone; SP, sea urchin; XL, frog.@(((:tag . "NNP") (:stem . "Species") (:form . "Species") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 21) (:start . 8) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "aa") (:form . "AA") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 63)\n  (:start . 55) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "AG") (:form . "AG") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 94) (:start . 93)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "BF") (:form . "BF") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 107)\n  (:start . 99) (:id . 62))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 108) (:start . 107)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "CL") (:form . "CL") (:end . 111) (:start . 109)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 65))\n ((:tag . "NN") (:stem . "bull") (:form . "bull") (:end . 117) (:start . 113)\n  (:id . 66))\n ((:tag . "NN") (:stem . "shark") (:form . "shark") (:end . 123)\n  (:start . 118) (:id . 67))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 124) (:start . 123)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 127) (:start . 125)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 131) (:start . 129)\n  (:id . 71))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 145) (:start . 132) (:id . 72))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 151)\n  (:start . 146) (:id . 73))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 155) (:start . 152)\n  (:id . 74))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 156) (:start . 155)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "FR") (:form . "FR") (:end . 159) (:start . 157)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 77))\n ((:tag . "NN") (:stem . "fugu") (:form . "fugu") (:end . 165) (:start . 161)\n  (:id . 78))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 170) (:start . 166)\n  (:id . 79))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 171) (:start . 170)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "HM") (:form . "HM") (:end . 174) (:start . 172)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 82))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 181)\n  (:start . 176) (:id . 83))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 182) (:start . 181)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 185) (:start . 183)\n  (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 192)\n  (:start . 187) (:id . 87))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 193) (:start . 192)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "NV") (:form . "NV") (:end . 196) (:start . 194)\n  (:id . 89))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 90))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 205)\n  (:start . 198) (:id . 91))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 209) (:start . 206)\n  (:id . 92))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 217)\n  (:start . 210) (:id . 93))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 218) (:start . 217)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 221) (:start . 219)\n  (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 96))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 226) (:start . 223)\n  (:id . 97))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 233)\n  (:start . 227) (:id . 98))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 234) (:start . 233)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "XL") (:form . "XL") (:end . 237) (:start . 235)\n  (:id . 100))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 101))\n ((:tag . "NN") (:stem . "frog") (:form . "frog") (:end . 243) (:start . 239)\n  (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s6.96) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101836@unknown@formal@none@1@S@(Transib1 through Transib5 are from D. melanogaster fruit fly.)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Transib1") (:form . "Transib1") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "transib5") (:form . "Transib5") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.97) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101837@unknown@formal@none@1@S@Common Structural Hallmarks of the Transib TPase and RAG1 Core@(((:tag . "JJ") (:stem . "common") (:form . "Common") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "structural") (:form . "Structural") (:end . 17)\n  (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "Hallmark") (:form . "Hallmarks") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Core") (:form . "Core") (:end . 62) (:start . 58)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.98) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101838@unknown@formal@none@1@S@All three core residues from the catalytic DDE triad in the RAG1 proteins (residues 603, 711, and 965) that are necessary for V(D)J recombination [21,22] are conserved in the Transib TPases (Figures 3 and Figure S3).@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 42)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "dde") (:form . "DDE") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 64) (:start . 60)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "CD") (:stem . "603") (:form . "603") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "711") (:form . "711") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 61))\n ((:tag . "CD") (:stem . "965") (:form . "965") (:end . 101) (:start . 98)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 107) (:start . 103)\n  (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 121)\n  (:start . 112) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 145) (:start . 132) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . "CD") (:stem . "21,22") (:form . "21,22") (:end . 152)\n  (:start . 147) (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 153) (:start . 152)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 157) (:start . 154)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 167)\n  (:start . 158) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 170) (:start . 168)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 182)\n  (:start . 175) (:id . 77))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 189)\n  (:start . 183) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 191) (:start . 190)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 198)\n  (:start . 191) (:id . 80))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 200) (:start . 199)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 211)\n  (:start . 205) (:id . 83))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 214) (:start . 212)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s6.99) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101840@unknown@formal@none@1@S@Moreover, each catalytic residue is a part of a motif that is conserved in the Transib TPases and RAG1 (motifs 4, 6, and 10 in Figures 3 and Figure S3).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 53) (:start . 48)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 71)\n  (:start . 62) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 93) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 102) (:start . 98)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 110)\n  (:start . 104) (:id . 63))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 112) (:start . 111)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 65))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 115) (:start . 114)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 68))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 123) (:start . 121)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 134)\n  (:start . 127) (:id . 71))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 136) (:start . 135)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 147)\n  (:start . 141) (:id . 74))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 150) (:start . 148)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 151) (:start . 150)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s6.101) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101841@unknown@formal@none@1@S@The RAG1 core is composed of the N-terminal region and the central and C-terminal domains ([26,27].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 81)\n  (:start . 71) (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 89)\n  (:start . 82) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CD") (:stem . "26,27") (:form . "26,27") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.102) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101842@unknown@formal@none@1@S@The N-terminal region includes the RSS nonamer-binding regions (residues 387–480), referred to as NBR [28,29].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "nonamer-binding") (:form . "nonamer-binding")\n  (:end . 54) (:start . 39) (:id . 48))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 72)\n  (:start . 64) (:id . 51))\n ((:tag . "CD") (:stem . "387–480") (:form . "387–480") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "NBR") (:form . "NBR") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "CD") (:stem . "28,29") (:form . "28,29") (:end . 108)\n  (:start . 103) (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.103) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101843@unknown@formal@none@1@S@The two terminal motifs of RAG1 NBR are conserved in the Transib TPases (Figure S3), which indicates that they may be important for their binding to the Transib TIRs during transposition (the RSS-like structure of TIRs is described below; Figure 4).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "NBR") (:form . "NBR") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 71) (:start . 65)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 90) (:start . 85)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 100)\n  (:start . 91) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 105) (:start . 101)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 110) (:start . 106)\n  (:id . 63))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 117) (:start . 115)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 127)\n  (:start . 118) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 131) (:start . 128)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 145)\n  (:start . 138) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 160)\n  (:start . 153) (:id . 72))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 165) (:start . 161)\n  (:id . 73))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 172)\n  (:start . 166) (:id . 74))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 186) (:start . 173) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 188) (:start . 187)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "rss-like") (:form . "RSS-like") (:end . 200)\n  (:start . 192) (:id . 78))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 210)\n  (:start . 201) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 218) (:start . 214)\n  (:id . 81))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 221) (:start . 219)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 231)\n  (:start . 222) (:id . 83))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 237)\n  (:start . 232) (:id . 84))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 238) (:start . 237)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 245)\n  (:start . 239) (:id . 86))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 247) (:start . 246)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x6.104.1) (:span 111 114))\n  ((:id . :x6.104.2) (:span 91 105)))\n (:hscopes ((:id . :x6.104.1) (:span 111 237))\n  ((:id . :x6.104.2) (:span 91 237)))\n (:identifiers (:sid . :s6.104) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101844@unknown@formal@none@1@S@The central domain of the RAG1 core (residues 531–763) includes two aspartic acid residues from the DDE triad and is also thought to be involved in binding to the RSS heptamer and RAG2 [30,31].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "central") (:form . "central") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "CD") (:stem . "531–763") (:form . "531–763") (:end . 53)\n  (:start . 46) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "aspartic") (:form . "aspartic") (:end . 76)\n  (:start . 68) (:id . 55))\n ((:tag . "NN") (:stem . "acid") (:form . "acid") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "DDE") (:form . "DDE") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 121) (:start . 117)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 129)\n  (:start . 122) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 135) (:start . 133)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 144)\n  (:start . 136) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 155)\n  (:start . 148) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 166) (:start . 163)\n  (:id . 73))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 175)\n  (:start . 167) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 184) (:start . 180)\n  (:id . 76))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 186) (:start . 185)\n  (:id . 77))\n ((:tag . "CD") (:stem . "30,31") (:form . "30,31") (:end . 191)\n  (:start . 186) (:id . 78))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 192) (:start . 191)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x6.105.1) (:span 122 129)))\n (:hscopes ((:id . :x6.105.1) (:span 114 184)))\n (:identifiers (:sid . :s6.105) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101845@unknown@formal@none@1@S@The C-terminal domain of RAG1 (residues 764–1011) is the portion of RAG1 that is most conserved between RAG1 and Transib TPases.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "CD") (:stem . "764–1011") (:form . "764–1011") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 77) (:start . 73)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 95)\n  (:start . 86) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 103)\n  (:start . 96) (:id . 60))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 120)\n  (:start . 113) (:id . 63))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 127)\n  (:start . 121) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s6.106) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101846@unknown@formal@none@1@S@In addition to the catalytic activity attributed to the last residue of the DDE triad, this domain has a strong nonspecific DNA-binding affinity because it binds to coding DNA upstream of the RSS heptamer, and is thought to be involved in RAG1 dimerization [26,27].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 37)\n  (:start . 29) (:id . 47))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "residue") (:form . "residue") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DDE") (:form . "DDE") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 111)\n  (:start . 105) (:id . 62))\n ((:tag . "JJ") (:stem . "nonspecific") (:form . "nonspecific") (:end . 123)\n  (:start . 112) (:id . 63))\n ((:tag . "JJ") (:stem . "dna-binding") (:form . "DNA-binding") (:end . 135)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "affinity") (:form . "affinity") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 155) (:start . 153)\n  (:id . 67))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 161)\n  (:start . 156) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 171)\n  (:start . 165) (:id . 70))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 184)\n  (:start . 176) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 191) (:start . 188)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 195) (:start . 192)\n  (:id . 75))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 204)\n  (:start . 196) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 212) (:start . 210)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 220)\n  (:start . 213) (:id . 80))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 223) (:start . 221)\n  (:id . 81))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 226) (:start . 224)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 235)\n  (:start . 227) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 238) (:start . 236)\n  (:id . 84))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 243) (:start . 239)\n  (:id . 85))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 256)\n  (:start . 244) (:id . 86))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 258) (:start . 257)\n  (:id . 87))\n ((:tag . "CD") (:stem . "26,27") (:form . "26,27") (:end . 263)\n  (:start . 258) (:id . 88))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 264) (:start . 263)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x6.107.1) (:span 213 220)))\n (:hscopes ((:id . :x6.107.1) (:span 210 256)))\n (:identifiers (:sid . :s6.107) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101847@unknown@formal@none@1@S@This domain is predicted to function analogously in Transib transposons.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "RB") (:stem . "analogously") (:form . "analogously") (:end . 48)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 71)\n  (:start . 60) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 52)))@@@1@11@((:hcues ((:id . :x6.108.1) (:span 15 24)))\n (:hscopes ((:id . :x6.108.1) (:span 0 71)))\n (:identifiers (:sid . :s6.108) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101848@unknown@formal@none@1@S@Several other motifs conserved in Transib TPases and RAG1 include aa residues that have been shown experimentally to be important for specific functions in V(D)J recombination (Figure S3).@(((:tag . "JJ") (:stem . "several") (:form . "Several") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 48) (:start . 42)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 87) (:start . 83)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 92) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "RB") (:stem . "experimentally") (:form . "experimentally")\n  (:end . 113) (:start . 99) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 142)\n  (:start . 134) (:id . 63))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 161)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 175) (:start . 162) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 183)\n  (:start . 177) (:id . 69))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 186) (:start . 184)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s6.109) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101850@unknown@formal@none@1@S@Among the most conserved motifs, motif 5 (see Figures 3 and Figure S3) is of particular interest because its function is not known yet but is expected to play a role both V(D)J recombination and Transib transposition.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 53)\n  (:start . 46) (:id . 52))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 66)\n  (:start . 60) (:id . 55))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 70) (:start . 69)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 87)\n  (:start . 77) (:id . 60))\n ((:tag . "NN") (:stem . "interest") (:form . "interest") (:end . 96)\n  (:start . 88) (:id . 61))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 104)\n  (:start . 97) (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 108) (:start . 105)\n  (:id . 63))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 117)\n  (:start . 109) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 124) (:start . 121)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 130)\n  (:start . 125) (:id . 67))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 134) (:start . 131)\n  (:id . 68))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 138) (:start . 135)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 141) (:start . 139)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 150)\n  (:start . 142) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 72))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 158) (:start . 154)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 160) (:start . 159)\n  (:id . 74))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 165) (:start . 161)\n  (:id . 75))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 170) (:start . 166)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 176)\n  (:start . 171) (:id . 77))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 190) (:start . 177) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 202)\n  (:start . 195) (:id . 80))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 216) (:start . 203) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x6.111.1) (:span 142 150))\n  ((:id . :x6.111.2) (:span 121 130)))\n (:hscopes ((:id . :x6.111.1) (:span 139 216))\n  ((:id . :x6.111.2) (:span 105 134)))\n (:identifiers (:sid . :s6.111) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101851@unknown@formal@none@1@S@In conjunction with detailed studies of the Transib superfamily, we also analyzed the remaining nine known superfamilies of DNA transposons defined by diverse TPases (see Table 1 in [24]).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conjunction") (:form . "conjunction") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 95)\n  (:start . 86) (:id . 56))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies")\n  (:end . 120) (:start . 107) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 127) (:start . 124)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 139)\n  (:start . 128) (:id . 62))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 147)\n  (:start . 140) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 158)\n  (:start . 151) (:id . 65))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 165)\n  (:start . 159) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 67))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 170) (:start . 167)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 176)\n  (:start . 171) (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 178) (:start . 177)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 183) (:start . 182)\n  (:id . 72))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.112) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101852@unknown@formal@none@1@S@Some of these TPases, including Mariner, Harbinger, P, and hAT, also contain the catalytic DDE triad [23].@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 20) (:start . 14)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "NNP") (:stem . "Mariner") (:form . "Mariner") (:end . 39)\n  (:start . 32) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Harbinger") (:form . "Harbinger") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "p") (:form . "P") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 56))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 68) (:start . 64)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 76)\n  (:start . 69) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 90)\n  (:start . 81) (:id . 60))\n ((:tag . "NN") (:stem . "dde") (:form . "DDE") (:end . 94) (:start . 91)\n  (:id . 61))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 100) (:start . 95)\n  (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 102) (:start . 101)\n  (:id . 63))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 104) (:start . 102)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 105) (:start . 104)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s6.113) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101853@unknown@formal@none@1@S@However, based on PSI-BLAST searches, no significant similarities between these nine TPases and RAG1 protein were found (data not shown).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 79) (:start . 74)\n  (:id . 53))\n ((:tag . "CD") (:stem . "nine") (:form . "nine") (:end . 84) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 91) (:start . 85)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 125)\n  (:start . 121) (:id . 62))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x6.114.1) (:span 126 129))\n  ((:id . :x6.114.2) (:span 38 40)))\n (:nscopes ((:id . :x6.114.1) (:span 120 136))\n  ((:id . :x6.114.2) (:span 38 119)))\n (:identifiers (:sid . :s6.114) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101854@unknown@formal@none@1@S@Therefore, given that the only significant similarity of the RAG1 core was to the Transib TPase, the RAG1 core was re-confirmed as belonging to the Transib superfamily.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 42)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 89)\n  (:start . 82) (:id . 57))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 95) (:start . 90)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 105) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "re-confirme") (:form . "re-confirmed") (:end . 127)\n  (:start . 115) (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "belong") (:form . "belonging") (:end . 140)\n  (:start . 131) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 155)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 167)\n  (:start . 156) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s6.115) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101855@unknown@formal@none@1@S@In addition to the statistically significant similarity between the approximately 600-aa RAG1 core and Transib TPases, there are two other lines of evidence suggesting evolution of the V(D)J machinery from Transib DNA transposons.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "RB") (:stem . "statistically") (:form . "statistically")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 44)\n  (:start . 33) (:id . 47))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 55)\n  (:start . 45) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 81) (:start . 68) (:id . 51))\n ((:tag . "JJ") (:stem . "600-aa") (:form . "600-aa") (:end . 88)\n  (:start . 82) (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 93) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 58))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 124)\n  (:start . 119) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 138)\n  (:start . 133) (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 144)\n  (:start . 139) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 167)\n  (:start . 157) (:id . 66))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 177)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 190)\n  (:start . 185) (:id . 70))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 200)\n  (:start . 191) (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 205) (:start . 201)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 213)\n  (:start . 206) (:id . 73))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 217) (:start . 214)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 229)\n  (:start . 218) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x6.116.1) (:span 157 167)))\n (:hscopes ((:id . :x6.116.1) (:span 157 229)))\n (:identifiers (:sid . :s6.116) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101856@unknown@formal@none@1@S@They include the characteristic TSDs and structure of the TIRs discussed in the next two sections.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 31) (:start . 17) (:id . 45))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "discuss") (:form . "discussed") (:end . 72)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.117) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101857@unknown@formal@none@1@S@Multiple Alignment of Ten Conserved Motifs in the RAG1 Core Proteins and Transib TPases@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "Alignment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "CD") (:stem . "ten") (:form . "Ten") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "Conserved") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "motif") (:form . "Motifs") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Core") (:form . "Core") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "Proteins") (:form . "Proteins") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "NNPS") (:stem . "TPas") (:form . "TPases") (:end . 87)\n  (:start . 81) (:id . 55)))@@@1@14@((:identifiers (:sid . :s6.118) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101858@unknown@formal@none@1@S@The motifs are underlined and numbered from 1 to 10.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "underline") (:form . "underlined") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "number") (:form . "numbered") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 45) (:start . 44)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 52) (:start . 51)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.119) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101860@unknown@formal@none@1@S@Distances between the motifs are indicated in numbers of aa residues.@(((:tag . "NNS") (:stem . "distance") (:form . "Distances") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.121) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101861@unknown@formal@none@1@S@Black circles denote conserved residues that form the RAG1/Transib catalytic DDE triad.@(((:tag . "JJ") (:stem . "black") (:form . "Black") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "circle") (:form . "circles") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "form") (:form . "form") (:end . 49) (:start . 45)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RAG1/Transib") (:form . "RAG1/Transib") (:end . 66)\n  (:start . 54) (:id . 50))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "dde") (:form . "DDE") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 86) (:start . 81)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.122) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101862@unknown@formal@none@1@S@The RAG1 proteins are as follows: RAG1_XL (GenBank GI no. 2501723, Xenopus laevis, frog), RAG1_HS (4557841, Homo sapiens, human), RAG1_GG (131826, Gallus gallus, chicken), RAG1_CL (1470117, Carcharhinus leucas, bull shark), RAG1_FR (4426834, Fugu rubripes, fugu fish).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RAG1_XL") (:form . "RAG1_XL") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 50)\n  (:start . 43) (:id . 51))\n ((:tag . "NNP") (:stem . "GI") (:form . "GI") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "no.") (:form . "no.") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2501723") (:form . "2501723") (:end . 65)\n  (:start . 58) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Xenopus") (:form . "Xenopus") (:end . 74)\n  (:start . 67) (:id . 56))\n ((:tag . "NNP") (:stem . "laevis") (:form . "laevis") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "NN") (:stem . "frog") (:form . "frog") (:end . 87) (:start . 83)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RAG1_HS") (:form . "RAG1_HS") (:end . 97)\n  (:start . 90) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 63))\n ((:tag . "CD") (:stem . "4557841") (:form . "4557841") (:end . 106)\n  (:start . 99) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Homo") (:form . "Homo") (:end . 112) (:start . 108)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 120)\n  (:start . 113) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 127)\n  (:start . 122) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "RAG1_GG") (:form . "RAG1_GG") (:end . 137)\n  (:start . 130) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 139) (:start . 138)\n  (:id . 73))\n ((:tag . "CD") (:stem . "131826") (:form . "131826") (:end . 145)\n  (:start . 139) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Gallus") (:form . "Gallus") (:end . 153)\n  (:start . 147) (:id . 76))\n ((:tag . "NN") (:stem . "gallus") (:form . "gallus") (:end . 160)\n  (:start . 154) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 78))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 169)\n  (:start . 162) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "RAG1_CL") (:form . "RAG1_CL") (:end . 179)\n  (:start . 172) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 181) (:start . 180)\n  (:id . 83))\n ((:tag . "CD") (:stem . "1470117") (:form . "1470117") (:end . 188)\n  (:start . 181) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "Carcharhinus") (:form . "Carcharhinus")\n  (:end . 202) (:start . 190) (:id . 86))\n ((:tag . "NNS") (:stem . "leuca") (:form . "leucas") (:end . 209)\n  (:start . 203) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 88))\n ((:tag . "NN") (:stem . "bull") (:form . "bull") (:end . 215) (:start . 211)\n  (:id . 89))\n ((:tag . "NN") (:stem . "shark") (:form . "shark") (:end . 221)\n  (:start . 216) (:id . 90))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 222) (:start . 221)\n  (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 223) (:start . 222)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "RAG1_FR") (:form . "RAG1_FR") (:end . 231)\n  (:start . 224) (:id . 93))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 94))\n ((:tag . "CD") (:stem . "4426834") (:form . "4426834") (:end . 240)\n  (:start . 233) (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 241) (:start . 240)\n  (:id . 96))\n ((:tag . "NNP") (:stem . "Fugu") (:form . "Fugu") (:end . 246) (:start . 242)\n  (:id . 97))\n ((:tag . "NNS") (:stem . "rubripe") (:form . "rubripes") (:end . 255)\n  (:start . 247) (:id . 98))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 256) (:start . 255)\n  (:id . 99))\n ((:tag . "NN") (:stem . "fugu") (:form . "fugu") (:end . 261) (:start . 257)\n  (:id . 100))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 266) (:start . 262)\n  (:id . 101))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 267) (:start . 266)\n  (:id . 102))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 268) (:start . 267)\n  (:id . 103)))@@@1@62@((:identifiers (:sid . :s6.123) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101863@unknown@formal@none@1@S@Coloring scheme [43] reflects physiochemical properties of amino acids: black shading marks hydrophobic residues, blue indicates charged (white font), positively charged (red font), and negatively charged (green font); red indicates proline (blue font) and glycine (green font); gray indicates aliphatic (red font) and aromatic (blue font); green indicates polar (black font) and amphoteric (red font); and yellow indicates tiny (blue font) and small (green font).@(((:tag . "VBG") (:stem . "color") (:form . "Coloring") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 17) (:start . 16)\n  (:id . 44))\n ((:tag . "CD") (:stem . "43") (:form . "43") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "reflect") (:form . "reflects") (:end . 29)\n  (:start . 21) (:id . 47))\n ((:tag . "JJ") (:stem . "physiochemical") (:form . "physiochemical")\n  (:end . 44) (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "shading") (:form . "shading") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "VBZ") (:stem . "mark") (:form . "marks") (:end . 91) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hydrophobic") (:form . "hydrophobic") (:end . 103)\n  (:start . 92) (:id . 57))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 112)\n  (:start . 104) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 118) (:start . 114)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "VBN") (:stem . "charge") (:form . "charged") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 148) (:start . 144)\n  (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 149) (:start . 148)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 161)\n  (:start . 151) (:id . 68))\n ((:tag . "VBN") (:stem . "charge") (:form . "charged") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 174) (:start . 171)\n  (:id . 71))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 179) (:start . 175)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 181) (:start . 180)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 75))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 196)\n  (:start . 186) (:id . 76))\n ((:tag . "VBN") (:stem . "charge") (:form . "charged") (:end . 204)\n  (:start . 197) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 206) (:start . 205)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 211)\n  (:start . 206) (:id . 79))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 216) (:start . 212)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 217) (:start . 216)\n  (:id . 81))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 218) (:start . 217)\n  (:id . 82))\n ((:tag . "NN") (:stem . "red") (:form . "red") (:end . 222) (:start . 219)\n  (:id . 83))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 232)\n  (:start . 223) (:id . 84))\n ((:tag . "NN") (:stem . "proline") (:form . "proline") (:end . 240)\n  (:start . 233) (:id . 85))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 242) (:start . 241)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 246) (:start . 242)\n  (:id . 87))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 251) (:start . 247)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 252) (:start . 251)\n  (:id . 89))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 256) (:start . 253)\n  (:id . 90))\n ((:tag . "NN") (:stem . "glycine") (:form . "glycine") (:end . 264)\n  (:start . 257) (:id . 91))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 266) (:start . 265)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 271)\n  (:start . 266) (:id . 93))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 276) (:start . 272)\n  (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 277) (:start . 276)\n  (:id . 95))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 278) (:start . 277)\n  (:id . 96))\n ((:tag . "NN") (:stem . "gray") (:form . "gray") (:end . 283) (:start . 279)\n  (:id . 97))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 293)\n  (:start . 284) (:id . 98))\n ((:tag . "JJ") (:stem . "aliphatic") (:form . "aliphatic") (:end . 303)\n  (:start . 294) (:id . 99))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 305) (:start . 304)\n  (:id . 100))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 308) (:start . 305)\n  (:id . 101))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 313) (:start . 309)\n  (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 314) (:start . 313)\n  (:id . 103))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 318) (:start . 315)\n  (:id . 104))\n ((:tag . "JJ") (:stem . "aromatic") (:form . "aromatic") (:end . 327)\n  (:start . 319) (:id . 105))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 329) (:start . 328)\n  (:id . 106))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 333) (:start . 329)\n  (:id . 107))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 338) (:start . 334)\n  (:id . 108))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 339) (:start . 338)\n  (:id . 109))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 340) (:start . 339)\n  (:id . 110))\n ((:tag . "NN") (:stem . "green") (:form . "green") (:end . 346)\n  (:start . 341) (:id . 111))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 356)\n  (:start . 347) (:id . 112))\n ((:tag . "JJ") (:stem . "polar") (:form . "polar") (:end . 362)\n  (:start . 357) (:id . 113))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 364) (:start . 363)\n  (:id . 114))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 369)\n  (:start . 364) (:id . 115))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 374) (:start . 370)\n  (:id . 116))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 375) (:start . 374)\n  (:id . 117))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 379) (:start . 376)\n  (:id . 118))\n ((:tag . "JJ") (:stem . "amphoteric") (:form . "amphoteric") (:end . 390)\n  (:start . 380) (:id . 119))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 392) (:start . 391)\n  (:id . 120))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 395) (:start . 392)\n  (:id . 121))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 400) (:start . 396)\n  (:id . 122))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 401) (:start . 400)\n  (:id . 123))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 402) (:start . 401)\n  (:id . 124))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 406) (:start . 403)\n  (:id . 125))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 413)\n  (:start . 407) (:id . 126))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 423)\n  (:start . 414) (:id . 127))\n ((:tag . "JJ") (:stem . "tiny") (:form . "tiny") (:end . 428) (:start . 424)\n  (:id . 128))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 430) (:start . 429)\n  (:id . 129))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 434) (:start . 430)\n  (:id . 130))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 439) (:start . 435)\n  (:id . 131))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 440) (:start . 439)\n  (:id . 132))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 444) (:start . 441)\n  (:id . 133))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 450)\n  (:start . 445) (:id . 134))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 452) (:start . 451)\n  (:id . 135))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 457)\n  (:start . 452) (:id . 136))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 462) (:start . 458)\n  (:id . 137))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 463) (:start . 462)\n  (:id . 138))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 464) (:start . 463)\n  (:id . 139)))@@@1@98@((:identifiers (:sid . :s6.124) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101864@unknown@formal@none@1@S@The species abbreviations for the Transib transposons are as follows: AA, yellow fever mosquito; AG, African malaria mosquito; DP, D. pseudoobscura fruit fly.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NN") (:stem . "aa") (:form . "AA") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 86) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "AG") (:form . "AG") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 133) (:start . 131)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 147) (:start . 134) (:id . 68))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 153)\n  (:start . 148) (:id . 69))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s6.125) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101865@unknown@formal@none@1@S@(Transib1 through Transib5 are from the fruitfly D. melanogaster.)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Transib1") (:form . "Transib1") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "transib5") (:form . "Transib5") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fruitfly") (:form . "fruitfly") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster") (:end . 64)\n  (:start . 52) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.126) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101866@unknown@formal@none@1@S@Structural Similarities between the Transib TIRs and V(D)J RSS Signals@(((:tag . "JJ") (:stem . "structural") (:form . "Structural") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "similarity") (:form . "Similarities") (:end . 23)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 43)\n  (:start . 36) (:id . 46))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 48) (:start . 44)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 58) (:start . 53)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NNPS") (:stem . "Signal") (:form . "Signals") (:end . 70)\n  (:start . 63) (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.127) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101867@unknown@formal@none@1@S@The species abbreviations are: AA, yellow fever mosquito; AG, African malaria mosquito; DM, D. melanogaster fruit fly DP, D. pseudoobscura fruit fly; SP, sea urchin.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 30) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "aa") (:form . "AA") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 41)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 57) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "AG") (:form . "AG") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 69)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 86)\n  (:start . 78) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "DM") (:form . "DM") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 107) (:start . 95) (:id . 62))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 113)\n  (:start . 108) (:id . 63))\n ((:tag . "NNP") (:stem . "fly") (:form . "fly") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 124) (:start . 122)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 138) (:start . 125) (:id . 68))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 144)\n  (:start . 139) (:id . 69))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 148) (:start . 145)\n  (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 149) (:start . 148)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 152) (:start . 150)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 73))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 157) (:start . 154)\n  (:id . 74))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 164)\n  (:start . 158) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.128) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101868@unknown@formal@none@1@S@(Transib1 through Transib5 are from the fruit fly D. melanogaster.)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Transib1") (:form . "Transib1") (:end . 9)\n  (:start . 1) (:id . 43))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "transib5") (:form . "Transib5") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster") (:end . 65)\n  (:start . 53) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.129) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101870@unknown@formal@none@1@S@The RSS23 consensus sequence is shown immediately under the TIRs consensus sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rss23") (:form . "RSS23") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "immediately") (:form . "immediately") (:end . 49)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "TIR") (:form . "TIRs") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 74)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.131) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101871@unknown@formal@none@1@S@The most conserved nucleotides in the RSS23 heptamer and nonamer, which are necessary for efficient V(D)J recombination, are highlighted.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rss23") (:form . "RSS23") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 99)\n  (:start . 90) (:id . 57))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 105)\n  (:start . 100) (:id . 58))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 119) (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "highlight") (:form . "highlighted") (:end . 136)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.132) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101872@unknown@formal@none@1@S@The 23 ± 1 bp variable spacer is marked by Ns.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "SYM") (:stem . "±") (:form . "±") (:end . 8) (:start . 7)\n  (:id . 44))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 13) (:start . 11)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 22)\n  (:start . 14) (:id . 47))\n ((:tag . "NN") (:stem . "spacer") (:form . "spacer") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 39) (:start . 33)\n  (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "N") (:form . "Ns") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 46) (:start . 45)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.133) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101873@unknown@formal@none@1@S@(B) Non-gapped alignment of consensus sequences of 5? TIRs from 21 families of Transib transposons.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "non-gapped") (:form . "Non-gapped") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 24)\n  (:start . 15) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 75)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 86)\n  (:start . 79) (:id . 58))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 98)\n  (:start . 87) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.134) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101874@unknown@formal@none@1@S@(C) The 12/23 rule follows from the basic structure of TIRs of the consensus sequences of transposons that belong to the Transib5, Transib2_AG, TransibN1_AG, TransibN2_AG, and TransibN3_AG families.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 7) (:start . 4)\n  (:id . 45))\n ((:tag . "CD") (:stem . "12/23") (:form . "12/23") (:end . 13) (:start . 8)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 18) (:start . 14)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 26)\n  (:start . 19) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "basic") (:form . "basic") (:end . 41) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 51)\n  (:start . 42) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 59) (:start . 55)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 56))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 76)\n  (:start . 67) (:id . 57))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 86)\n  (:start . 77) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 101)\n  (:start . 90) (:id . 60))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Transib5") (:form . "Transib5") (:end . 129)\n  (:start . 121) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 142)\n  (:start . 131) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TransibN1_AG") (:form . "TransibN1_AG")\n  (:end . 156) (:start . 144) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "TransibN2_AG") (:form . "TransibN2_AG")\n  (:end . 170) (:start . 158) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 175) (:start . 172)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "TransibN3_AG") (:form . "TransibN3_AG")\n  (:end . 188) (:start . 176) (:id . 74))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 197)\n  (:start . 189) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.135) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101875@unknown@formal@none@1@S@The 5? TIRs of these transposons are aligned with the corresponding 3? TIRs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 44))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 11) (:start . 7)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 20) (:start . 15)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 32)\n  (:start . 21) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "align") (:form . "aligned") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 67)\n  (:start . 54) (:id . 53))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s6.136) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101876@unknown@formal@none@1@S@Structures of the 5? and 3? TIRs resemble RSS12 and RSS23, respectively.@(((:tag . "NNP") (:stem . "Structure") (:form . "Structures") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 27) (:start . 26)\n  (:id . 49))\n ((:tag . "NNPS") (:stem . "TIR") (:form . "TIRs") (:end . 32) (:start . 28)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "resemble") (:form . "resemble") (:end . 41)\n  (:start . 33) (:id . 51))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 47) (:start . 42)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RSS23") (:form . "RSS23") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 55))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 71)\n  (:start . 59) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s6.137) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101877@unknown@formal@none@1@S@Similar Length of TSDs and Target Site Composition in Transib and RAG1/2-Mediated Transpositions@(((:tag . "JJ") (:stem . "similar") (:form . "Similar") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Length") (:form . "Length") (:end . 14)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "TSD") (:form . "TSDs") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "target") (:form . "Target") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNP") (:stem . "Site") (:form . "Site") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Composition") (:form . "Composition") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rag1/2-mediated") (:form . "RAG1/2-Mediated")\n  (:end . 81) (:start . 66) (:id . 53))\n ((:tag . "NNPS") (:stem . "Transposition") (:form . "Transpositions")\n  (:end . 96) (:start . 82) (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.138) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101878@unknown@formal@none@1@S@It has been known that RAG1-mediated transposition in vitro, both intermolecular and intramolecular, is most frequently accompanied by 5-bp TSDs [12,13].@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "rag1-mediated") (:form . "RAG1-mediated")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 50) (:start . 37) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intermolecular") (:form . "intermolecular")\n  (:end . 80) (:start . 66) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "intramolecular") (:form . "intramolecular")\n  (:end . 99) (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 108) (:start . 104)\n  (:id . 58))\n ((:tag . "RB") (:stem . "frequently") (:form . "frequently") (:end . 119)\n  (:start . 109) (:id . 59))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 131)\n  (:start . 120) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 139) (:start . 135)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 144) (:start . 140)\n  (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "CD") (:stem . "12,13") (:form . "12,13") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 152) (:start . 151)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.139) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101880@unknown@formal@none@1@S@Also, 69% of 36 TSDs recovered during RAG-mediated intramolecular transpositions were 5 bp in length; of the remaining ones, 28% were 4 bp and 3% were 3 bp long.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "CD") (:stem . "69") (:form . "69") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 9) (:start . 8)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 46))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 15) (:start . 13)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 20) (:start . 16)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 30)\n  (:start . 21) (:id . 49))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 37)\n  (:start . 31) (:id . 50))\n ((:tag . "JJ") (:stem . "rag-mediated") (:form . "RAG-mediated") (:end . 50)\n  (:start . 38) (:id . 51))\n ((:tag . "JJ") (:stem . "intramolecular") (:form . "intramolecular")\n  (:end . 65) (:start . 51) (:id . 52))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 80) (:start . 66) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 100)\n  (:start . 94) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 127) (:start . 125)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 128) (:start . 127)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 135) (:start . 134)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 138) (:start . 136)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 142) (:start . 139)\n  (:id . 70))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 144) (:start . 143)\n  (:id . 71))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 145) (:start . 144)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 150) (:start . 146)\n  (:id . 73))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 152) (:start . 151)\n  (:id . 74))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 155) (:start . 153)\n  (:id . 75))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 160) (:start . 156)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s6.141) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101881@unknown@formal@none@1@S@In another study [13], six of six TSDs detected in the intermolecular transposition were 5 bp long.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "CD") (:stem . "13") (:form . "13") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 21) (:start . 20)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 48))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 26) (:start . 23)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 50))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 33) (:start . 30)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 38) (:start . 34)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 47)\n  (:start . 39) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intermolecular") (:form . "intermolecular")\n  (:end . 69) (:start . 55) (:id . 56))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 83) (:start . 70) (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 88) (:start . 84)\n  (:id . 58))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.142) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101882@unknown@formal@none@1@S@Intramolecular transposition mediated by murine RAG1/2 proteins was also studied recently in vivo in yeast [14].@(((:tag . "JJ") (:stem . "intramolecular") (:form . "Intramolecular")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 28) (:start . 15) (:id . 43))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 37)\n  (:start . 29) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "murine") (:form . "murine") (:end . 47)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "rag1/2") (:form . "RAG1/2") (:end . 54)\n  (:start . 48) (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 63)\n  (:start . 55) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 67) (:start . 64)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 72) (:start . 68)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "study") (:form . "studied") (:end . 80)\n  (:start . 73) (:id . 51))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 89)\n  (:start . 81) (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 97) (:start . 93)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 106)\n  (:start . 101) (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.143) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101883@unknown@formal@none@1@S@Again, 60% of TSDs recovered in 26 events were 5 bp long [14].@(((:tag . "RB") (:stem . "again") (:form . "Again") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 10) (:start . 9)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 18) (:start . 14)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 28)\n  (:start . 19) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 49))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 34) (:start . 32)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "event") (:form . "events") (:end . 41)\n  (:start . 35) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 48) (:start . 47)\n  (:id . 53))\n ((:tag . "NN") (:stem . "bp") (:form . "bp") (:end . 51) (:start . 49)\n  (:id . 54))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 56) (:start . 52)\n  (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 58) (:start . 57)\n  (:id . 56))\n ((:tag . "CD") (:stem . "14") (:form . "14") (:end . 60) (:start . 58)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 61) (:start . 60)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.144) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101884@unknown@formal@none@1@S@Given the predominance of 5-bp TSDs, it is striking that Transib transposons belong to the only superfamily of eukaryotic DNA transposons with 5-bp TSDs generated upon insertions into the genome [17,24].@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "predominance") (:form . "predominance") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "striking") (:form . "striking") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 76)\n  (:start . 65) (:id . 54))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 83)\n  (:start . 77) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 107)\n  (:start . 96) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 121)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 137)\n  (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 147) (:start . 143)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "generate") (:form . "generated") (:end . 162)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 167) (:start . 163)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "insertion") (:form . "insertions") (:end . 178)\n  (:start . 168) (:id . 69))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 183) (:start . 179)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 187) (:start . 184)\n  (:id . 71))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 194)\n  (:start . 188) (:id . 72))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . "CD") (:stem . "17,24") (:form . "17,24") (:end . 201)\n  (:start . 196) (:id . 74))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 202) (:start . 201)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.145) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101885@unknown@formal@none@1@S@To illustrate the characteristic 5-bp TSDs, we show copies of Transib transposons with intact 5? and 3? TIRs from diverse families of Transib transposons present in the D. melanogaster, D. pseudoobscura, A. gambiae, and S. purpuratus genomes (Figure S4).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "illustrate") (:form . "illustrate") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 32) (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 42) (:start . 38)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 58) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 81)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 108) (:start . 104)\n  (:id . 62))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 121)\n  (:start . 114) (:id . 64))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 141)\n  (:start . 134) (:id . 67))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 153)\n  (:start . 142) (:id . 68))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 161)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 184) (:start . 172) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 188) (:start . 186)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 202) (:start . 189) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "A.") (:form . "A.") (:end . 206) (:start . 204)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "gambiae") (:form . "gambiae") (:end . 214)\n  (:start . 207) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 222) (:start . 220)\n  (:id . 82))\n ((:tag . "NN") (:stem . "purpuratus") (:form . "purpuratus") (:end . 233)\n  (:start . 223) (:id . 83))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 241)\n  (:start . 234) (:id . 84))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 243) (:start . 242)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 249)\n  (:start . 243) (:id . 86))\n ((:tag . "NNP") (:stem . "S4") (:form . "S4") (:end . 252) (:start . 250)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 253) (:start . 252)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s6.146) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101886@unknown@formal@none@1@S@Moreover, some families show high target site specificity, e.g., Transib-N1_AG and Transib-N2_AG integrate preferentially at cCASTGg and cCAWTGc, respectively (TSDs are capitalized).@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 57)\n  (:start . 46) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib-N1_AG") (:form . "Transib-N1_AG")\n  (:end . 78) (:start . 65) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Transib-N2_AG") (:form . "Transib-N2_AG")\n  (:end . 96) (:start . 83) (:id . 56))\n ((:tag . "NN") (:stem . "integrate") (:form . "integrate") (:end . 106)\n  (:start . 97) (:id . 57))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 121) (:start . 107) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 124) (:start . 122)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ccastgg") (:form . "cCASTGg") (:end . 132)\n  (:start . 125) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ccawtgc") (:form . "cCAWTGc") (:end . 144)\n  (:start . 137) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 63))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 158)\n  (:start . 146) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 160) (:start . 159)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 164) (:start . 160)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 168) (:start . 165)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "capitalize") (:form . "capitalized") (:end . 180)\n  (:start . 169) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.147) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101887@unknown@formal@none@1@S@RAG1/2-mediated transpositions also show significant target specificity, presumably reflecting the original specificity of the Transib TPase [12].@(((:tag . "JJ") (:stem . "rag1/2-mediated") (:form . "RAG1/2-mediated")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 30) (:start . 16) (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 35) (:start . 31)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 40) (:start . 36)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 52)\n  (:start . 41) (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 59)\n  (:start . 53) (:id . 47))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 71)\n  (:start . 60) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 49))\n ((:tag . "RB") (:stem . "presumably") (:form . "presumably") (:end . 83)\n  (:start . 73) (:id . 50))\n ((:tag . "VBG") (:stem . "reflect") (:form . "reflecting") (:end . 94)\n  (:start . 84) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 98) (:start . 95)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "original") (:form . "original") (:end . 107)\n  (:start . 99) (:id . 53))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 119)\n  (:start . 108) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 134)\n  (:start . 127) (:id . 57))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 140)\n  (:start . 135) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 142) (:start . 141)\n  (:id . 59))\n ((:tag . "CD") (:stem . "12") (:form . "12") (:end . 144) (:start . 142)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 145) (:start . 144)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x6.148.1) (:span 73 83)))\n (:hscopes ((:id . :x6.148.1) (:span 73 140)))\n (:identifiers (:sid . :s6.148) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101888@unknown@formal@none@1@S@Indigenous properties of the Transib TPase, that were not related directly to RAG1 functions, including those responsible for the precise 5-bp length of TSDs, might have been altered during evolution of RAG1, leading to occasional 4-bp and 3-bp TSDs that are atypical for Transib transposons.@(((:tag . "JJ") (:stem . "indigenous") (:form . "Indigenous") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 21)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 103)\n  (:start . 94) (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "JJ") (:stem . "responsible") (:form . "responsible") (:end . 121)\n  (:start . 110) (:id . 60))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 125) (:start . 122)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "precise") (:form . "precise") (:end . 137)\n  (:start . 130) (:id . 63))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 142) (:start . 138)\n  (:id . 64))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "TSD") (:form . "TSDs") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 174) (:start . 170)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 182)\n  (:start . 175) (:id . 72))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 189)\n  (:start . 183) (:id . 73))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 199)\n  (:start . 190) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 207) (:start . 203)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 216)\n  (:start . 209) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "occasional") (:form . "occasional") (:end . 230)\n  (:start . 220) (:id . 80))\n ((:tag . "JJ") (:stem . "4-bp") (:form . "4-bp") (:end . 235) (:start . 231)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 239) (:start . 236)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "3-bp") (:form . "3-bp") (:end . 244) (:start . 240)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 249) (:start . 245)\n  (:id . 84))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 254) (:start . 250)\n  (:id . 85))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 258) (:start . 255)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "atypical") (:form . "atypical") (:end . 267)\n  (:start . 259) (:id . 87))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 271) (:start . 268)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 279)\n  (:start . 272) (:id . 89))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 291)\n  (:start . 280) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 292) (:start . 291)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x6.149.2) (:span 159 164)))\n (:ncues ((:id . :x6.149.1) (:span 54 57)))\n (:hscopes ((:id . :x6.149.2) (:span 0 207)))\n (:nscopes ((:id . :x6.149.1) (:span 54 157)))\n (:identifiers (:sid . :s6.149) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101890@unknown@formal@none@1@S@Structure of Transib TIRs@(((:tag . "NN") (:stem . "structure") (:form . "Structure") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "NNPS") (:stem . "TIR") (:form . "TIRs") (:end . 25) (:start . 21)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s6.151) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101891@unknown@formal@none@1@S@The structure and conservation patterns of the 38-bp termini of Transib transposons from 21 different families closely resemble those of RSSs, suggesting that the latter were derived from termini of ancient Transib transposons (Figures 4 and S4).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 30)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "38-bp") (:form . "38-bp") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 83)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 54))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 91) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 118)\n  (:start . 111) (:id . 58))\n ((:tag . "VBP") (:stem . "resemble") (:form . "resemble") (:end . 127)\n  (:start . 119) (:id . 59))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 133)\n  (:start . 128) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 136) (:start . 134)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSSs") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 153)\n  (:start . 143) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 158) (:start . 154)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 169)\n  (:start . 163) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 174) (:start . 170)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 182)\n  (:start . 175) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 187) (:start . 183)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 195)\n  (:start . 188) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 206)\n  (:start . 199) (:id . 73))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 214)\n  (:start . 207) (:id . 74))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 226)\n  (:start . 215) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 228) (:start . 227)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 235)\n  (:start . 228) (:id . 77))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 237) (:start . 236)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 241) (:start . 238)\n  (:id . 79))\n ((:tag . "NN") (:stem . "s4") (:form . "S4") (:end . 244) (:start . 242)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 245) (:start . 244)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 246) (:start . 245)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x6.152.1) (:span 143 153)))\n (:hscopes ((:id . :x6.152.1) (:span 143 226)))\n (:identifiers (:sid . :s6.152) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101892@unknown@formal@none@1@S@The 38-bp consensus TIR of Transib transposons consists of a conserved 5?- CACAATG heptamer separated by a variable 23-bp spacer from an AAAAAAATC-3? nonamer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "38-bp") (:form . "38-bp") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "tir") (:form . "TIR") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "VBZ") (:stem . "consist") (:form . "consists") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cacaatg") (:form . "CACAATG") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 91)\n  (:start . 83) (:id . 55))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 101)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "JJ") (:stem . "23-bp") (:form . "23-bp") (:end . 121)\n  (:start . 116) (:id . 60))\n ((:tag . "NN") (:stem . "spacer") (:form . "spacer") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 133) (:start . 129)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NN") (:stem . "aaaaaaatc-3") (:form . "AAAAAAATC-3") (:end . 148)\n  (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 157)\n  (:start . 150) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.153) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101893@unknown@formal@none@1@S@This corresponds closely to the structure of RSSs, which are composed of the conserved heptamers 5?- CACAGTG separated by a variable 22-bp spacers from ACAAAAACC-like nonamers [1,5–7].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSSs") (:end . 49) (:start . 45)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 56) (:start . 51)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "heptamer") (:form . "heptamers") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NN") (:stem . "cacagtg") (:form . "CACAGTG") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "VBN") (:stem . "separate") (:form . "separated") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "variable") (:form . "variable") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "JJ") (:stem . "22-bp") (:form . "22-bp") (:end . 138)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "spacer") (:form . "spacers") (:end . 146)\n  (:start . 139) (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 151) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "acaaaaacc-like") (:form . "ACAAAAACC-like")\n  (:end . 166) (:start . 152) (:id . 67))\n ((:tag . "NNS") (:stem . "nonamer") (:form . "nonamers") (:end . 175)\n  (:start . 167) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 177) (:start . 176)\n  (:id . 69))\n ((:tag . "CD") (:stem . "1,5–7") (:form . "1,5–7") (:end . 182)\n  (:start . 177) (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s6.154) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101894@unknown@formal@none@1@S@Only bases at positions 1 through 3 in the heptamer and at positions 5 and 6 in the nonamer are universally conserved in RSSs and absolutely essential for efficient V(D)J recombination [5–7].@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "base") (:form . "bases") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 68)\n  (:start . 59) (:id . 54))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 91)\n  (:start . 84) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 61))\n ((:tag . "RB") (:stem . "universally") (:form . "universally") (:end . 107)\n  (:start . 96) (:id . 62))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 117)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSSs") (:end . 125) (:start . 121)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 66))\n ((:tag . "RB") (:stem . "absolutely") (:form . "absolutely") (:end . 140)\n  (:start . 130) (:id . 67))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 150)\n  (:start . 141) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 164)\n  (:start . 155) (:id . 70))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 170)\n  (:start . 165) (:id . 71))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 184) (:start . 171) (:id . 72))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "CD") (:stem . "5–7") (:form . "5–7") (:end . 189) (:start . 186)\n  (:id . 74))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 190) (:start . 189)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.155) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101895@unknown@formal@none@1@S@The corresponding positions are perfectly conserved in all Transib transposons (Figure 4A and 4B; excluding the 85% conserved position 34 in the Transib consensus that corresponds to position 5 in the RSS nonamer).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "RB") (:stem . "perfectly") (:form . "perfectly") (:end . 41)\n  (:start . 32) (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 51)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 80) (:start . 79)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "NN") (:stem . "4a") (:form . "4A") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 55))\n ((:tag . "NN") (:stem . "4b") (:form . "4B") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "CD") (:stem . "85") (:form . "85") (:end . 114) (:start . 112)\n  (:id . 60))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 152)\n  (:start . 145) (:id . 67))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 162)\n  (:start . 153) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 167) (:start . 163)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 179)\n  (:start . 168) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 182) (:start . 180)\n  (:id . 71))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 191)\n  (:start . 183) (:id . 72))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 193) (:start . 192)\n  (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 196) (:start . 194)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 204) (:start . 201)\n  (:id . 76))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 212)\n  (:start . 205) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 213) (:start . 212)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.156) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101896@unknown@formal@none@1@S@The probability of the observed match between the RSS and Transib termini to occur by chance is less than 10-3 (see Materials and Methods).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "match") (:form . "match") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 45)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 82) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "CD") (:stem . "10-3") (:form . "10-3") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 125)\n  (:start . 116) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 65))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 138) (:start . 137)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s6.157) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101897@unknown@formal@none@1@S@Although most Transib families are represented by transposons flanked by TIRs similar to RSS23 (Figure 4A), several families include transposons with 5? and 3? termini similar to RSS12 and RSS23, respectively (Figure 4C).@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 61)\n  (:start . 50) (:id . 49))\n ((:tag . "VBN") (:stem . "flank") (:form . "flanked") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 77) (:start . 73)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RSS23") (:form . "RSS23") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 102)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "4a") (:form . "4A") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 115)\n  (:start . 108) (:id . 61))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 124)\n  (:start . 116) (:id . 62))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 144)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 152) (:start . 151)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 156) (:start . 153)\n  (:id . 68))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 167)\n  (:start . 160) (:id . 71))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "NN") (:stem . "rss12") (:form . "RSS12") (:end . 184)\n  (:start . 179) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "RSS23") (:form . "RSS23") (:end . 194)\n  (:start . 189) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 195) (:start . 194)\n  (:id . 77))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 208)\n  (:start . 196) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 210) (:start . 209)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 216)\n  (:start . 210) (:id . 80))\n ((:tag . "NN") (:stem . "4c") (:form . "4C") (:end . 219) (:start . 217)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s6.158) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101898@unknown@formal@none@1@S@Therefore, even the 12/23 rule [1] can be derived directly from the sequence structure of known Transib transposons.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "12/23") (:form . "12/23") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rule") (:form . "rule") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 49)\n  (:start . 42) (:id . 53))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 58)\n  (:start . 50) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 63) (:start . 59)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 76)\n  (:start . 68) (:id . 57))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 86)\n  (:start . 77) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 95) (:start . 90)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 103)\n  (:start . 96) (:id . 61))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 115)\n  (:start . 104) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.159) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101900@unknown@formal@none@1@S@Using RAG1 proteins as query sequences in a WU BLAST search against sea urchin contigs sequenced at Baylor College (see Materials and Methods), we identified eight proteins approximately 30% identical to portions of the RAG1 core and approximately 50% identical to each other (see Figures 2, 5, and S5).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "WU") (:form . "WU") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 86)\n  (:start . 79) (:id . 56))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Baylor") (:form . "Baylor") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "College") (:form . "College") (:end . 114)\n  (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 119) (:start . 116)\n  (:id . 62))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 129)\n  (:start . 120) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 141)\n  (:start . 134) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 157)\n  (:start . 147) (:id . 69))\n ((:tag . "CD") (:stem . "eight") (:form . "eight") (:end . 163)\n  (:start . 158) (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 172)\n  (:start . 164) (:id . 71))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 186) (:start . 173) (:id . 72))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 200)\n  (:start . 191) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 203) (:start . 201)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 212)\n  (:start . 204) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 79))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 224) (:start . 220)\n  (:id . 80))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 229) (:start . 225)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 233) (:start . 230)\n  (:id . 82))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 247) (:start . 234) (:id . 83))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 250) (:start . 248)\n  (:id . 84))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 251) (:start . 250)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 261)\n  (:start . 252) (:id . 86))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 264) (:start . 262)\n  (:id . 87))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 269) (:start . 265)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 275)\n  (:start . 270) (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 277) (:start . 276)\n  (:id . 90))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 280) (:start . 277)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 288)\n  (:start . 281) (:id . 92))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 290) (:start . 289)\n  (:id . 93))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 291) (:start . 290)\n  (:id . 94))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 293) (:start . 292)\n  (:id . 95))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 294) (:start . 293)\n  (:id . 96))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 298) (:start . 295)\n  (:id . 97))\n ((:tag . "NN") (:stem . "s5") (:form . "S5") (:end . 301) (:start . 299)\n  (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 302) (:start . 301)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 303) (:start . 302)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s6.161) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101901@unknown@formal@none@1@S@Only one protein is present in two copies, which are 94% identical to each other at the DNA level (contigs 81987 and 6797).@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 41) (:start . 35)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "CD") (:stem . "94") (:form . "94") (:end . 55) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 56) (:start . 55)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 66)\n  (:start . 57) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 74) (:start . 70)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 80) (:start . 75)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 83) (:start . 81)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 91) (:start . 88)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 97) (:start . 92)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 106)\n  (:start . 99) (:id . 64))\n ((:tag . "CD") (:stem . "81987") (:form . "81987") (:end . 112)\n  (:start . 107) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 66))\n ((:tag . "CD") (:stem . "6797") (:form . "6797") (:end . 121) (:start . 117)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.162) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101902@unknown@formal@none@1@S@Both copies appear to be encoded by pseudogenes damaged by a stop codon at the same position of each protein.@(((:tag . "DT") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 47)\n  (:start . 36) (:id . 49))\n ((:tag . "VBN") (:stem . "damage") (:form . "damaged") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "codon") (:form . "codon") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 92)\n  (:start . 84) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 108)\n  (:start . 101) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 62)))@@@1@21@((:hcues ((:id . :x6.163.1) (:span 12 18)))\n (:hscopes ((:id . :x6.163.1) (:span 0 108)))\n (:identifiers (:sid . :s6.163) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101903@unknown@formal@none@1@S@Interestingly, the 6,690-bp contig 6797 harbours two additional defective pseudogenes coding for different RAG1 core–like proteins (Figure 5).@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "6,690-bp") (:form . "6,690-bp") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 34)\n  (:start . 28) (:id . 46))\n ((:tag . "CD") (:stem . "6797") (:form . "6797") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "harbour") (:form . "harbours") (:end . 48)\n  (:start . 40) (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 63)\n  (:start . 53) (:id . 50))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 92) (:start . 86)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 96) (:start . 93)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 106)\n  (:start . 97) (:id . 55))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 111) (:start . 107)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 121)\n  (:start . 112) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 130)\n  (:start . 122) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 138)\n  (:start . 132) (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 141) (:start . 140)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.164) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101904@unknown@formal@none@1@S@We also identified a 597-aa protein sequence encoded by a single open reading frame (contig 29068, positions 1157–2944), which is 28% identical to nearly the entire RAG1 core (positions 461–1002 in the human RAG1, Figure S5).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "597-aa") (:form . "597-aa") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "CD") (:stem . "29068") (:form . "29068") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 108)\n  (:start . 99) (:id . 60))\n ((:tag . "CD") (:stem . "1157–2944") (:form . "1157–2944") (:end . 118)\n  (:start . 109) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 126)\n  (:start . 121) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 133) (:start . 132)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 143)\n  (:start . 134) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 153)\n  (:start . 147) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 164)\n  (:start . 158) (:id . 72))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 169) (:start . 165)\n  (:id . 73))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 174) (:start . 170)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 176) (:start . 175)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 185)\n  (:start . 176) (:id . 76))\n ((:tag . "CD") (:stem . "461–1002") (:form . "461–1002") (:end . 194)\n  (:start . 186) (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 201) (:start . 198)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 207)\n  (:start . 202) (:id . 80))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 212) (:start . 208)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 220)\n  (:start . 214) (:id . 83))\n ((:tag . "NNP") (:stem . "S5") (:form . "S5") (:end . 223) (:start . 221)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s6.165) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101905@unknown@formal@none@1@S@Extensive analysis of the flanks failed to show any hallmarks of putative transposons that might be associated with this RAG1-like protein, and we did not find any evidence indicating that other RAG1 core–like proteins are encoded by transposable elements (Figure 5).@(((:tag . "JJ") (:stem . "extensive") (:form . "Extensive") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "flank") (:form . "flanks") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "fail") (:form . "failed") (:end . 39) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "show") (:form . "show") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "hallmark") (:form . "hallmarks") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 73)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 110)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 120) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 130)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 146) (:start . 144)\n  (:id . 65))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 154) (:start . 151)\n  (:id . 67))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 159) (:start . 155)\n  (:id . 68))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 163) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 172)\n  (:start . 164) (:id . 70))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 183)\n  (:start . 173) (:id . 71))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 188) (:start . 184)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 194)\n  (:start . 189) (:id . 73))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 199) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 218)\n  (:start . 210) (:id . 76))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 222) (:start . 219)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 230)\n  (:start . 223) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 233) (:start . 231)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "transposable") (:form . "transposable") (:end . 246)\n  (:start . 234) (:id . 80))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 255)\n  (:start . 247) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 257) (:start . 256)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 263)\n  (:start . 257) (:id . 83))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 265) (:start . 264)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 266) (:start . 265)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x6.166.1) (:span 173 188)) ((:id . :x6.166.3) (:span 91 96))\n  ((:id . :x6.166.4) (:span 65 73)))\n (:ncues ((:id . :x6.166.2) (:span 151 154))\n  ((:id . :x6.166.5) (:span 33 39)))\n (:hscopes ((:id . :x6.166.1) (:span 173 255))\n  ((:id . :x6.166.3) (:span 86 138)) ((:id . :x6.166.4) (:span 65 138)))\n (:nscopes ((:id . :x6.166.2) (:span 151 255))\n  ((:id . :x6.166.5) (:span 33 138)))\n (:identifiers (:sid . :s6.166) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101906@unknown@formal@none@1@S@Using FGENESH [33], we detected that the RAG1 core–like open reading frame (ORF) in the contig 29068 forms a terminal exon (positions 1154–2947) of an incomplete hypothetical gene composed of two exons (internal and terminal; see Figure S6).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "FGENESH") (:form . "FGENESH") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 22) (:start . 20)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 31)\n  (:start . 23) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 36) (:start . 32)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 45) (:start . 41)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 55)\n  (:start . 46) (:id . 53))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "reading") (:form . "reading") (:end . 68)\n  (:start . 61) (:id . 55))\n ((:tag . "NN") (:stem . "frame") (:form . "frame") (:end . 74) (:start . 69)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "ORF") (:form . "ORF") (:end . 79) (:start . 76)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 61))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 94)\n  (:start . 88) (:id . 62))\n ((:tag . "CD") (:stem . "29068") (:form . "29068") (:end . 100) (:start . 95)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 106)\n  (:start . 101) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 108) (:start . 107)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 117)\n  (:start . 109) (:id . 66))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 122) (:start . 118)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 133)\n  (:start . 124) (:id . 69))\n ((:tag . "CD") (:stem . "1154–2947") (:form . "1154–2947") (:end . 143)\n  (:start . 134) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 144) (:start . 143)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 150) (:start . 148)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 161)\n  (:start . 151) (:id . 74))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 174)\n  (:start . 162) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 179) (:start . 175)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 188)\n  (:start . 180) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 78))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 195) (:start . 192)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 201)\n  (:start . 196) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 203) (:start . 202)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 211)\n  (:start . 203) (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 215) (:start . 212)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 224)\n  (:start . 216) (:id . 84))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 225) (:start . 224)\n  (:id . 85))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 229) (:start . 226)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 236)\n  (:start . 230) (:id . 87))\n ((:tag . "NNP") (:stem . "S6") (:form . "S6") (:end . 239) (:start . 237)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 240) (:start . 239)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s6.167) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101907@unknown@formal@none@1@S@The 3? terminal portion of the internal exon encodes a protein sequence that appears to be marginally similar to an approximately 50-aa fragment of the RAG1 core (positions 394–454 in human RAG1; Figure S5).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 5) (:start . 4)\n  (:id . 43))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 6) (:start . 5) (:id . 44))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 15)\n  (:start . 7) (:id . 45))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "internal") (:form . "internal") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 44) (:start . 40)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 52)\n  (:start . 45) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 62)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 71)\n  (:start . 63) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "RB") (:stem . "marginally") (:form . "marginally") (:end . 101)\n  (:start . 91) (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 109)\n  (:start . 102) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 129) (:start . 116) (:id . 63))\n ((:tag . "JJ") (:stem . "50-aa") (:form . "50-aa") (:end . 135)\n  (:start . 130) (:id . 64))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 144)\n  (:start . 136) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 172)\n  (:start . 163) (:id . 71))\n ((:tag . "CD") (:stem . "394–454") (:form . "394–454") (:end . 180)\n  (:start . 173) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 194) (:start . 190)\n  (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 195) (:start . 194)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 202)\n  (:start . 196) (:id . 77))\n ((:tag . "NNP") (:stem . "S5") (:form . "S5") (:end . 205) (:start . 203)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 206) (:start . 205)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x6.168.1) (:span 77 84)))\n (:hscopes ((:id . :x6.168.1) (:span 72 194)))\n (:identifiers (:sid . :s6.168) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101908@unknown@formal@none@1@S@The RAG1 core–like protein in whole genome shotgun (WGS) contig 12509 (Figure 5) also seems to be encoded by the last exon starting at position 1650 of a hypothetical RAG1-like gene.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "whole") (:form . "whole") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "shotgun") (:form . "shotgun") (:end . 50)\n  (:start . 43) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "WGS") (:form . "WGS") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 63)\n  (:start . 57) (:id . 53))\n ((:tag . "CD") (:stem . "12509") (:form . "12509") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 77)\n  (:start . 71) (:id . 56))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 80) (:start . 79)\n  (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 85) (:start . 81)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 91) (:start . 86)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 97) (:start . 95)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 105)\n  (:start . 98) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "last") (:form . "last") (:end . 117) (:start . 113)\n  (:id . 66))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 122) (:start . 118)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "start") (:form . "starting") (:end . 131)\n  (:start . 123) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 134) (:start . 132)\n  (:id . 69))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 143)\n  (:start . 135) (:id . 70))\n ((:tag . "CD") (:stem . "1650") (:form . "1650") (:end . 148) (:start . 144)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 151) (:start . 149)\n  (:id . 72))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 153) (:start . 152)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 166)\n  (:start . 154) (:id . 74))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 176)\n  (:start . 167) (:id . 75))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 181) (:start . 177)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x6.169.1) (:span 154 166))\n  ((:id . :x6.169.2) (:span 86 91)))\n (:hscopes ((:id . :x6.169.1) (:span 154 181))\n  ((:id . :x6.169.2) (:span 0 181)))\n (:identifiers (:sid . :s6.169) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101910@unknown@formal@none@1@S@Remarkably, the acceptor splice site positions in the sea urchin RAG1 core–like proteins closely correspond to those in RAG1 from teleosts (i.e., most of the living ray-finned or bony fish), in which RAG1 is split by an intron at position homologous to Gly460 in human RAG1 [34].@(((:tag . "RB") (:stem . "remarkably") (:form . "Remarkably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "acceptor") (:form . "acceptor") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "splice") (:form . "splice") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 88)\n  (:start . 80) (:id . 55))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . "VBP") (:stem . "correspond") (:form . "correspond") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 124) (:start . 120)\n  (:id . 61))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "teleost") (:form . "teleosts") (:end . 138)\n  (:start . 130) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "NN") (:stem . "living") (:form . "living") (:end . 164)\n  (:start . 158) (:id . 70))\n ((:tag . "JJ") (:stem . "ray-finned") (:form . "ray-finned") (:end . 175)\n  (:start . 165) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "bony") (:form . "bony") (:end . 183) (:start . 179)\n  (:id . 73))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 193) (:start . 191)\n  (:id . 77))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 199)\n  (:start . 194) (:id . 78))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 204) (:start . 200)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 207) (:start . 205)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "split") (:form . "split") (:end . 213)\n  (:start . 208) (:id . 81))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 216) (:start . 214)\n  (:id . 82))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 219) (:start . 217)\n  (:id . 83))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 226)\n  (:start . 220) (:id . 84))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 229) (:start . 227)\n  (:id . 85))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 238)\n  (:start . 230) (:id . 86))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 249)\n  (:start . 239) (:id . 87))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 252) (:start . 250)\n  (:id . 88))\n ((:tag . "NN") (:stem . "gly460") (:form . "Gly460") (:end . 259)\n  (:start . 253) (:id . 89))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 262) (:start . 260)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 268)\n  (:start . 263) (:id . 91))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 273) (:start . 269)\n  (:id . 92))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 275) (:start . 274)\n  (:id . 93))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 277) (:start . 275)\n  (:id . 94))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 278) (:start . 277)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s6.171) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101911@unknown@formal@none@1@S@Using the same RAG1 query sequences in a TBLASTN search against WGS trace sequences from the lancelet (Branchiostoma floridae) genome recently sequenced at the Joint Genome Institute (see Materials and Methods), we found that the lancelet genome encodes protein sequences approximately 35% identical to the RAG1 core (Figure S5; RAG1L_BF; BLASTP E-value is equal to 10-34).@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "TBLASTN") (:form . "TBLASTN") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "NNP") (:stem . "WGS") (:form . "WGS") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 83)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 101)\n  (:start . 93) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "branchiostoma") (:form . "Branchiostoma")\n  (:end . 116) (:start . 103) (:id . 60))\n ((:tag . "NN") (:stem . "floridae") (:form . "floridae") (:end . 125)\n  (:start . 117) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 142)\n  (:start . 134) (:id . 64))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 155) (:start . 153)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Joint") (:form . "Joint") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . "NNP") (:stem . "Genome") (:form . "Genome") (:end . 172)\n  (:start . 166) (:id . 69))\n ((:tag . "NNP") (:stem . "Institute") (:form . "Institute") (:end . 182)\n  (:start . 173) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 187) (:start . 184)\n  (:id . 72))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 197)\n  (:start . 188) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 201) (:start . 198)\n  (:id . 74))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 209)\n  (:start . 202) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 211) (:start . 210)\n  (:id . 77))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 214) (:start . 212)\n  (:id . 78))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 220)\n  (:start . 215) (:id . 79))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 225) (:start . 221)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 81))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 238)\n  (:start . 230) (:id . 82))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 245)\n  (:start . 239) (:id . 83))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 253)\n  (:start . 246) (:id . 84))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 261)\n  (:start . 254) (:id . 85))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 271)\n  (:start . 262) (:id . 86))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 285) (:start . 272) (:id . 87))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 288) (:start . 286)\n  (:id . 88))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 289) (:start . 288)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 299)\n  (:start . 290) (:id . 90))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 302) (:start . 300)\n  (:id . 91))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 306) (:start . 303)\n  (:id . 92))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 311) (:start . 307)\n  (:id . 93))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 316) (:start . 312)\n  (:id . 94))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 318) (:start . 317)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 324)\n  (:start . 318) (:id . 96))\n ((:tag . "NNP") (:stem . "S5") (:form . "S5") (:end . 327) (:start . 325)\n  (:id . 97))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 328) (:start . 327)\n  (:id . 98))\n ((:tag . "NNP") (:stem . "RAG1L_BF") (:form . "RAG1L_BF") (:end . 337)\n  (:start . 329) (:id . 99))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 338) (:start . 337)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 345)\n  (:start . 339) (:id . 101))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 353)\n  (:start . 346) (:id . 102))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 356) (:start . 354)\n  (:id . 103))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 362)\n  (:start . 357) (:id . 104))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 365) (:start . 363)\n  (:id . 105))\n ((:tag . "CD") (:stem . "10-34") (:form . "10-34") (:end . 371)\n  (:start . 366) (:id . 106))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 372) (:start . 371)\n  (:id . 107))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 373) (:start . 372)\n  (:id . 108)))@@@1@67@((:identifiers (:sid . :s6.172) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101912@unknown@formal@none@1@S@Again, as in the case of the sea urchin sequences, the lancelet RAG1 core–like elements show no hallmarks of transposons (data not shown).@(((:tag . "RB") (:stem . "again") (:form . "Again") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 32) (:start . 29)\n  (:id . 50))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 39)\n  (:start . 33) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 49)\n  (:start . 40) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 54))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 63)\n  (:start . 55) (:id . 55))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 68) (:start . 64)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 78)\n  (:start . 69) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 87)\n  (:start . 79) (:id . 58))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "hallmark") (:form . "hallmarks") (:end . 105)\n  (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 120)\n  (:start . 109) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 126)\n  (:start . 122) (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 130) (:start . 127)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 136)\n  (:start . 131) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 137) (:start . 136)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x6.173.1) (:span 127 130))\n  ((:id . :x6.173.2) (:span 93 95)))\n (:nscopes ((:id . :x6.173.1) (:span 121 137))\n  ((:id . :x6.173.2) (:span 93 120)))\n (:identifiers (:sid . :s6.173) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101913@unknown@formal@none@1@S@However, unlike highly conserved RAG1 proteins, the RAG1 core–like proteins are remarkably diverse (see Figure 2).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "RB") (:stem . "remarkably") (:form . "remarkably") (:end . 90)\n  (:start . 80) (:id . 55))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 110)\n  (:start . 104) (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 114) (:start . 113)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.174) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101914@unknown@formal@none@1@S@During the second review of the manuscript of this article, we were kindly informed by Dr.@(((:tag . "IN") (:stem . "during") (:form . "During") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "review") (:form . "review") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "manuscript") (:form . "manuscript") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "article") (:form . "article") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 54))\n ((:tag . "RB") (:stem . "kindly") (:form . "kindly") (:end . 74)\n  (:start . 68) (:id . 55))\n ((:tag . "VBN") (:stem . "inform") (:form . "informed") (:end . 83)\n  (:start . 75) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Dr") (:form . "Dr") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.175) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101915@unknown@formal@none@1@S@Hervé Philippe of a RAG1 core–like sequence present the starlet sea anemone (Nematostella vectensis).@(((:tag . "NNP") (:stem . "Hervé") (:form . "Hervé") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Philippe") (:form . "Philippe") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 43)\n  (:start . 35) (:id . 48))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 75)\n  (:start . 68) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Nematostella") (:form . "Nematostella") (:end . 89)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "vectensis") (:form . "vectensis") (:end . 99)\n  (:start . 90) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 100) (:start . 99)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.176) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101916@unknown@formal@none@1@S@After that, we screened all available Trace Archives (Materials and Methods) and detected additional RAG1-like proteins.@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 14) (:start . 12)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "screen") (:form . "screened") (:end . 23)\n  (:start . 15) (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 43) (:start . 38)\n  (:id . 49))\n ((:tag . "NNPS") (:stem . "Archives") (:form . "Archives") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.177) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101917@unknown@formal@none@1@S@In starlet sea anemone, several approximately 1000-bp WGS trace sequences were found (e.g., GenBank Trace Archive IDs 668021618, 558173651, 568641192, and 599572062), which encode protein, called RAG1L_NV, that is approximately 30% identical to the human RAG1 core (positions 284–802, TBLASTN, 10-26 < E < 10-7).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 45) (:start . 32) (:id . 48))\n ((:tag . "JJ") (:stem . "1000-bp") (:form . "1000-bp") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "wgs") (:form . "WGS") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 63) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 55))\n ((:tag . "FW") (:stem . "e.g.") (:form . "e.g.") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 99)\n  (:start . 92) (:id . 58))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNP") (:stem . "Archive") (:form . "Archive") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "NNP") (:stem . "IDs") (:form . "IDs") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "CD") (:stem . "668021618") (:form . "668021618") (:end . 127)\n  (:start . 118) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . "CD") (:stem . "558173651") (:form . "558173651") (:end . 138)\n  (:start . 129) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 65))\n ((:tag . "CD") (:stem . "568641192") (:form . "568641192") (:end . 149)\n  (:start . 140) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "CD") (:stem . "599572062") (:form . "599572062") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 71))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 172)\n  (:start . 167) (:id . 72))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 179)\n  (:start . 173) (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 187)\n  (:start . 180) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 195)\n  (:start . 189) (:id . 76))\n ((:tag . "NNP") (:stem . "RAG1L_NV") (:form . "RAG1L_NV") (:end . 204)\n  (:start . 196) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 210) (:start . 206)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 213) (:start . 211)\n  (:id . 80))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 227) (:start . 214) (:id . 81))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 230) (:start . 228)\n  (:id . 82))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 231) (:start . 230)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 241)\n  (:start . 232) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 244) (:start . 242)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 248) (:start . 245)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 254)\n  (:start . 249) (:id . 87))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 259) (:start . 255)\n  (:id . 88))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 264) (:start . 260)\n  (:id . 89))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 266) (:start . 265)\n  (:id . 90))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 275)\n  (:start . 266) (:id . 91))\n ((:tag . "CD") (:stem . "284–802") (:form . "284–802") (:end . 283)\n  (:start . 276) (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 284) (:start . 283)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "TBLASTN") (:form . "TBLASTN") (:end . 292)\n  (:start . 285) (:id . 94))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 293) (:start . 292)\n  (:id . 95))\n ((:tag . "CD") (:stem . "10-26") (:form . "10-26") (:end . 299)\n  (:start . 294) (:id . 96))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 301) (:start . 300)\n  (:id . 97))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 303) (:start . 302)\n  (:id . 98))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 305) (:start . 304)\n  (:id . 99))\n ((:tag . "CD") (:stem . "10-7") (:form . "10-7") (:end . 310) (:start . 306)\n  (:id . 100))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 311) (:start . 310)\n  (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 312) (:start . 311)\n  (:id . 102)))@@@1@61@((:identifiers (:sid . :s6.178) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101918@unknown@formal@none@1@S@We also found several approximately 1000-bp WGS trace sequences of Hydra magnipapillata (Trace Archive IDs 688654311, 647073738, 666995387, 687186526, 688683890, and 688948453), coding for protein sequences 26%-30% identical to the RAG1 core (positions 753-995, E-value is approximately equal to 10-7 in a BLASTX search against GenBank).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 35) (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "1000-bp") (:form . "1000-bp") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "wgs") (:form . "WGS") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Hydra") (:form . "Hydra") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "magnipapillata") (:form . "magnipapillata")\n  (:end . 87) (:start . 73) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 89) (:start . 88)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Archive") (:form . "Archive") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "NNP") (:stem . "IDs") (:form . "IDs") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "CD") (:stem . "688654311") (:form . "688654311") (:end . 116)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "CD") (:stem . "647073738") (:form . "647073738") (:end . 127)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "CD") (:stem . "666995387") (:form . "666995387") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 63))\n ((:tag . "CD") (:stem . "687186526") (:form . "687186526") (:end . 149)\n  (:start . 140) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 65))\n ((:tag . "CD") (:stem . "688683890") (:form . "688683890") (:end . 160)\n  (:start . 151) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 68))\n ((:tag . "CD") (:stem . "688948453") (:form . "688948453") (:end . 175)\n  (:start . 166) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 176) (:start . 175)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 184)\n  (:start . 178) (:id . 72))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 188) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 196)\n  (:start . 189) (:id . 74))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 206)\n  (:start . 197) (:id . 75))\n ((:tag . "CD") (:stem . "26%-30") (:form . "26%-30") (:end . 213)\n  (:start . 207) (:id . 76))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 214) (:start . 213)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 224)\n  (:start . 215) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 227) (:start . 225)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 80))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 236) (:start . 232)\n  (:id . 81))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 241) (:start . 237)\n  (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 243) (:start . 242)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 252)\n  (:start . 243) (:id . 84))\n ((:tag . "CD") (:stem . "753-995") (:form . "753-995") (:end . 260)\n  (:start . 253) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 261) (:start . 260)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 269)\n  (:start . 262) (:id . 87))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 272) (:start . 270)\n  (:id . 88))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 286) (:start . 273) (:id . 89))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 292)\n  (:start . 287) (:id . 90))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 295) (:start . 293)\n  (:id . 91))\n ((:tag . "CD") (:stem . "10-7") (:form . "10-7") (:end . 300) (:start . 296)\n  (:id . 92))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 303) (:start . 301)\n  (:id . 93))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 305) (:start . 304)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "BLASTX") (:form . "BLASTX") (:end . 312)\n  (:start . 306) (:id . 95))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 319)\n  (:start . 313) (:id . 96))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 327)\n  (:start . 320) (:id . 97))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 335)\n  (:start . 328) (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 336) (:start . 335)\n  (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 337) (:start . 336)\n  (:id . 100)))@@@1@59@((:identifiers (:sid . :s6.179) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101920@unknown@formal@none@1@S@Remarkably, the hydra RAG1L_NM protein turned out to be significantly similar to the Transib TPase (26% identity; E-value is approximately equal to 10-14 in a BLASTX search against GenBank proteins combined with the Transib TPase sequences).@(((:tag . "RB") (:stem . "remarkably") (:form . "Remarkably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1L_NM") (:form . "RAG1L_NM") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "VBD") (:stem . "turn") (:form . "turned") (:end . 45) (:start . 39)\n  (:id . 48))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 69) (:start . 56) (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 92)\n  (:start . 85) (:id . 56))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 98) (:start . 93)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 102) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 112)\n  (:start . 104) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 121)\n  (:start . 114) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 138) (:start . 125) (:id . 65))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 144)\n  (:start . 139) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 67))\n ((:tag . "CD") (:stem . "10-14") (:form . "10-14") (:end . 153)\n  (:start . 148) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "BLASTX") (:form . "BLASTX") (:end . 165)\n  (:start . 159) (:id . 71))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 172)\n  (:start . 166) (:id . 72))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 180)\n  (:start . 173) (:id . 73))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 188)\n  (:start . 181) (:id . 74))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 197)\n  (:start . 189) (:id . 75))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 206)\n  (:start . 198) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 211) (:start . 207)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 223)\n  (:start . 216) (:id . 79))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 229)\n  (:start . 224) (:id . 80))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 239)\n  (:start . 230) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 240) (:start . 239)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s6.181) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101921@unknown@formal@none@1@S@Therefore, the hydra RAG1 core–like protein provides the first direct link between the RAG1 core and Transib TPase.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 20) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 69)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "link") (:form . "link") (:end . 74) (:start . 70)\n  (:id . 53))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.182) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101922@unknown@formal@none@1@S@Schematic Structure of the Sea Urchin RAG1-Like Sequences@(((:tag . "JJ") (:stem . "schematic") (:form . "Schematic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Structure") (:form . "Structure") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Urchin") (:form . "Urchin") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1-Like") (:form . "RAG1-Like") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "Sequence") (:form . "Sequences") (:end . 57)\n  (:start . 48) (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.183) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101923@unknown@formal@none@1@S@Contig accession numbers are shown in the left column.@(((:tag . "NNP") (:stem . "Contig") (:form . "Contig") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "accession") (:form . "accession") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "left") (:form . "left") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.184) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101924@unknown@formal@none@1@S@Inverted complement contigs are marked by “c” followed by the contig number.@(((:tag . "VBN") (:stem . "invert") (:form . "Inverted") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "complement") (:form . "complement") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 38) (:start . 32)\n  (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 43) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "follow") (:form . "followed") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 75)\n  (:start . 69) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s6.185) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101925@unknown@formal@none@1@S@In each contig, RAG1-like proteins (white rectangle) are schematically aligned with the human RAG1 core (top rectangle).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rectangle") (:form . "rectangle") (:end . 51)\n  (:start . 42) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "RB") (:stem . "schematically") (:form . "schematically")\n  (:end . 70) (:start . 57) (:id . 53))\n ((:tag . "VBN") (:stem . "align") (:form . "aligned") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rectangle") (:form . "rectangle") (:end . 118)\n  (:start . 109) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.186) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101926@unknown@formal@none@1@S@Nucleotide positions of the RAG1-like sequences are shown beneath the white rectangles.@(((:tag . "NN") (:stem . "nucleotide") (:form . "Nucleotide") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 57) (:start . 52)\n  (:id . 49))\n ((:tag . "IN") (:stem . "beneath") (:form . "beneath") (:end . 65)\n  (:start . 58) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.187) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101927@unknown@formal@none@1@S@Three pairs of recently duplicated sequences (nucleotide identity is higher than 95%) are underlined by red, green, and black lines, respectively.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "pair") (:form . "pairs") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "VBN") (:stem . "duplicate") (:form . "duplicated") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 56)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 65)\n  (:start . 57) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 75) (:start . 69)\n  (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "CD") (:stem . "95") (:form . "95") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "underline") (:form . "underlined") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 114)\n  (:start . 109) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 125)\n  (:start . 120) (:id . 65))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 131)\n  (:start . 126) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 67))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 145)\n  (:start . 133) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.188) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101928@unknown@formal@none@1@S@Transposable and repetitive elements detected in the flanking regions are marked by painted rectangles.@(((:tag . "JJ") (:stem . "transposable") (:form . "Transposable") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "repetitive") (:form . "repetitive") (:end . 27)\n  (:start . 17) (:id . 44))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 36)\n  (:start . 28) (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 45)\n  (:start . 37) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 73) (:start . 70)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 80) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "paint") (:form . "painted") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 102)\n  (:start . 92) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s6.189) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101930@unknown@formal@none@1@S@Asterisks denote stop codons in the corresponding RAG1-like sequences.@(((:tag . "NNP") (:stem . "Asterisk") (:form . "Asterisks") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "denote") (:form . "denote") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 49)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 59)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 69)\n  (:start . 60) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.191) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101931@unknown@formal@none@1@S@BLASTP E-values characterizing similarities between the sea urchin and RAG1 proteins are shown above the white rectangles.@(((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-values") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBG") (:stem . "characterize") (:form . "characterizing")\n  (:end . 30) (:start . 16) (:id . 44))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 43)\n  (:start . 31) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 51)\n  (:start . 44) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 59) (:start . 56)\n  (:id . 48))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 66)\n  (:start . 60) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 75) (:start . 71)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 84)\n  (:start . 76) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 94) (:start . 89)\n  (:id . 54))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 100) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.192) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101932@unknown@formal@none@1@S@Multiple alignment of these protein sequences is reported in Figure S5.@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 35)\n  (:start . 28) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NNP") (:stem . "S5") (:form . "S5") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 71) (:start . 70)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.193) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101933@unknown@formal@none@1@S@N-Terminal–Like Domain of RAG1 in the Sea Urchin, Lancelet, Starlet Sea Anemone, and Hydra Genomes@(((:tag . "NNP") (:stem . "N-Terminal–Like") (:form . "N-Terminal–Like")\n  (:end . 15) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Domain") (:form . "Domain") (:end . 22)\n  (:start . 16) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Urchin") (:form . "Urchin") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Lancelet") (:form . "Lancelet") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Starlet") (:form . "Starlet") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Anemone") (:form . "Anemone") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Hydra") (:form . "Hydra") (:end . 90) (:start . 85)\n  (:id . 58))\n ((:tag . "NNPS") (:stem . "Genome") (:form . "Genomes") (:end . 98)\n  (:start . 91) (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.194) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5101934@unknown@formal@none@1@S@A separate analysis of the assembled sea urchin sequences yielded seven sequences encoding three diverse proteins that were significantly similar to the 380-aa N-terminal domain of RAG1 (BLASTX, E < 10-4), excluding the 100-aa N-terminus (Figure 6).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 47)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 57)\n  (:start . 48) (:id . 50))\n ((:tag . "VBD") (:stem . "yield") (:form . "yielded") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "CD") (:stem . "seven") (:form . "seven") (:end . 71) (:start . 66)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 104)\n  (:start . 97) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 113)\n  (:start . 105) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 137) (:start . 124) (:id . 60))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 145)\n  (:start . 138) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "380-aa") (:form . "380-aa") (:end . 159)\n  (:start . 153) (:id . 64))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 170)\n  (:start . 160) (:id . 65))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 177)\n  (:start . 171) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 180) (:start . 178)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 185) (:start . 181)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "BLASTX") (:form . "BLASTX") (:end . 193)\n  (:start . 187) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 196) (:start . 195)\n  (:id . 72))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 198) (:start . 197)\n  (:id . 73))\n ((:tag . "CD") (:stem . "10-4") (:form . "10-4") (:end . 203) (:start . 199)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 215)\n  (:start . 206) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "100-aa") (:form . "100-aa") (:end . 226)\n  (:start . 220) (:id . 79))\n ((:tag . "NNP") (:stem . "N-terminus") (:form . "N-terminus") (:end . 237)\n  (:start . 227) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 239) (:start . 238)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 245)\n  (:start . 239) (:id . 82))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 247) (:start . 246)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 248) (:start . 247)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s6.195) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101935@unknown@formal@none@1@S@The first 305-aa protein is encoded by contig 1226, and its recently duplicated copies are on contigs 1219 and 1222 (approximately 95% identical to each other at the protein level).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "305-aa") (:form . "305-aa") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "CD") (:stem . "1226") (:form . "1226") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 68)\n  (:start . 60) (:id . 54))\n ((:tag . "VBN") (:stem . "duplicate") (:form . "duplicated") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 86) (:start . 80)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 101)\n  (:start . 94) (:id . 59))\n ((:tag . "CD") (:stem . "1219") (:form . "1219") (:end . 106) (:start . 102)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "CD") (:stem . "1222") (:form . "1222") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 130) (:start . 117) (:id . 64))\n ((:tag . "CD") (:stem . "95") (:form . "95") (:end . 133) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 144)\n  (:start . 135) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 147) (:start . 145)\n  (:id . 68))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 158)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 173)\n  (:start . 166) (:id . 73))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.196) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101936@unknown@formal@none@1@S@The second, 195-aa protein (contig 83099) is the shortest.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "195-aa") (:form . "195-aa") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "CD") (:stem . "83099") (:form . "83099") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "shortest") (:form . "shortest") (:end . 57)\n  (:start . 49) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.197) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101937@unknown@formal@none@1@S@It is only approximately 26% identical to the first protein and more than 90% identical at the DNA level to its duplicate on contig 86231.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 24) (:start . 11) (:id . 45))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 59)\n  (:start . 52) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 87)\n  (:start . 78) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 104) (:start . 99)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 111) (:start . 108)\n  (:id . 64))\n ((:tag . "NN") (:stem . "duplicate") (:form . "duplicate") (:end . 121)\n  (:start . 112) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 66))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 131)\n  (:start . 125) (:id . 67))\n ((:tag . "CD") (:stem . "86231") (:form . "86231") (:end . 137)\n  (:start . 132) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.198) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101938@unknown@formal@none@1@S@We also found a third protein on contig 768 that contains unique motifs in its N-terminal regions that best match the homologous regions of RAG1.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "contig") (:form . "contig") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "CD") (:stem . "768") (:form . "768") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 57)\n  (:start . 49) (:id . 52))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 89)\n  (:start . 79) (:id . 57))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "JJS") (:stem . "good") (:form . "best") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "match") (:form . "match") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 128)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.199) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101940@unknown@formal@none@1@S@By analyzing the lancelet WGS traces, we also found that the lancelet genome encodes five different proteins similar to the N-terminal domain of RAG1 (BLASTP E values in searches against all GenBank proteins were in a range of 10-14–10-7).@(((:tag . "IN") (:stem . "by") (:form . "By") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "analyze") (:form . "analyzing") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "wgs") (:form . "WGS") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "trace") (:form . "traces") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 69)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 99)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 108)\n  (:start . 100) (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 134)\n  (:start . 124) (:id . 63))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 157)\n  (:start . 151) (:id . 68))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 166)\n  (:start . 160) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 178)\n  (:start . 170) (:id . 72))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 186)\n  (:start . 179) (:id . 73))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 190) (:start . 187)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 198)\n  (:start . 191) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 207)\n  (:start . 199) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 212) (:start . 208)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 217) (:start . 216)\n  (:id . 79))\n ((:tag . "NN") (:stem . "range") (:form . "range") (:end . 223)\n  (:start . 218) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 226) (:start . 224)\n  (:id . 81))\n ((:tag . "CD") (:stem . "10-14–10-7") (:form . "10-14–10-7") (:end . 237)\n  (:start . 227) (:id . 82))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 238) (:start . 237)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s6.201) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101941@unknown@formal@none@1@S@DNA sequences coding for these proteins, P1_BF through P5_BF, were manually assembled from overlapping WGS sequences (data available upon request).@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 20) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "P1_BF") (:form . "P1_BF") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "NNP") (:stem . "P5_BF") (:form . "P5_BF") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "RB") (:stem . "manually") (:form . "manually") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "NNP") (:stem . "WGS") (:form . "WGS") (:end . 106) (:start . 103)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 116)\n  (:start . 107) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 122)\n  (:start . 118) (:id . 61))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 132)\n  (:start . 123) (:id . 62))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "request") (:form . "request") (:end . 145)\n  (:start . 138) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s6.202) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101942@unknown@formal@none@1@S@The proteins detected in the sea urchin and lancelet genome share a ring finger motif as well as two novel motifs matching the N-terminal RAG1 domain (Figure 6) and remotely resembling C-x2-C zinc finger motifs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 79)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 85) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "novel") (:form . "novel") (:end . 106)\n  (:start . 101) (:id . 61))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 113)\n  (:start . 107) (:id . 62))\n ((:tag . "VBG") (:stem . "match") (:form . "matching") (:end . 122)\n  (:start . 114) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 137)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 159) (:start . 158)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 72))\n ((:tag . "RB") (:stem . "remotely") (:form . "remotely") (:end . 173)\n  (:start . 165) (:id . 73))\n ((:tag . "VBG") (:stem . "resemble") (:form . "resembling") (:end . 184)\n  (:start . 174) (:id . 74))\n ((:tag . "NNP") (:stem . "C-x2-C") (:form . "C-x2-C") (:end . 191)\n  (:start . 185) (:id . 75))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 196) (:start . 192)\n  (:id . 76))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 203)\n  (:start . 197) (:id . 77))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 210)\n  (:start . 204) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.203) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101943@unknown@formal@none@1@S@The new conserved motifs are H-x3-L-x3-C-R-x-C-G and D-x3-I-h-P-x2-F-C-x2-C, and their function remains to be determined.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "H-x3-L-x3-C-R-x-C-G")\n  (:form . "H-x3-L-x3-C-R-x-C-G") (:end . 48) (:start . 29) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "D-x3-I-h-P-x2-F-C-x2-C")\n  (:form . "D-x3-I-h-P-x2-F-C-x2-C") (:end . 75) (:start . 53) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 51))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 86)\n  (:start . 81) (:id . 52))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 95)\n  (:start . 87) (:id . 53))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 103)\n  (:start . 96) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 109) (:start . 107)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "determine") (:form . "determined") (:end . 120)\n  (:start . 110) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 58)))@@@1@17@((:hcues ((:id . :x6.204.1) (:span 96 120)))\n (:hscopes ((:id . :x6.204.1) (:span 81 120)))\n (:identifiers (:sid . :s6.204) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101944@unknown@formal@none@1@S@It is thought that the ring finger motif of RAG1 functions as a zinc-binding domain, is involved in dimerization [30,35], and acts as an E3 ligase in the ubiquitylation [36].@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "zinc-binding") (:form . "zinc-binding") (:end . 76)\n  (:start . 64) (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "dimerization") (:form . "dimerization") (:end . 112)\n  (:start . 100) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "CD") (:stem . "30,35") (:form . "30,35") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 120) (:start . 119)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 130) (:start . 126)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 133) (:start . 131)\n  (:id . 68))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 136) (:start . 134)\n  (:id . 69))\n ((:tag . "NN") (:stem . "e3") (:form . "E3") (:end . 139) (:start . 137)\n  (:id . 70))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 146)\n  (:start . 140) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 73))\n ((:tag . "NN") (:stem . "ubiquitylation") (:form . "ubiquitylation")\n  (:end . 168) (:start . 154) (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 170) (:start . 169)\n  (:id . 75))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 172) (:start . 170)\n  (:id . 76))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 173) (:start . 172)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x6.205.1) (:span 6 13)))\n (:hscopes ((:id . :x6.205.1) (:span 6 168)))\n (:identifiers (:sid . :s6.205) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101945@unknown@formal@none@1@S@It also likely that the N-terminal RAG1 and RAG1-like proteins share an additional conserved motif W-x-p-h-x(3–6)-C-x2-C that resides between conserved motif 2 and the ring finger (Figure 6).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 68) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 82)\n  (:start . 72) (:id . 54))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 92)\n  (:start . 83) (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "W-x-p-h-x(3–6)-C-x2-C")\n  (:form . "W-x-p-h-x(3–6)-C-x2-C") (:end . 120) (:start . 99) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 125) (:start . 121)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "reside") (:form . "resides") (:end . 133)\n  (:start . 126) (:id . 59))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 141)\n  (:start . 134) (:id . 60))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 151)\n  (:start . 142) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 157)\n  (:start . 152) (:id . 62))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 159) (:start . 158)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 163) (:start . 160)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 172) (:start . 168)\n  (:id . 66))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 179)\n  (:start . 173) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 181) (:start . 180)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 187)\n  (:start . 181) (:id . 69))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 189) (:start . 188)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x6.206.1) (:span 8 14)))\n (:hscopes ((:id . :x6.206.1) (:span 8 179)))\n (:identifiers (:sid . :s6.206) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101946@unknown@formal@none@1@S@None of the sea urchin and lancelet proteins align to the approximately 100-aa N-terminus of RAG1, which may indicate that this portion is missing from the genome or highly diverged and difficult to detect.@(((:tag . "NN") (:stem . "none") (:form . "None") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 35)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "VBP") (:stem . "align") (:form . "align") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 71) (:start . 58) (:id . 53))\n ((:tag . "JJ") (:stem . "100-aa") (:form . "100-aa") (:end . 78)\n  (:start . 72) (:id . 54))\n ((:tag . "NN") (:stem . "n-terminus") (:form . "N-terminus") (:end . 89)\n  (:start . 79) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 97) (:start . 93)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 104)\n  (:start . 99) (:id . 59))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "VB") (:stem . "indicate") (:form . "indicate") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 135)\n  (:start . 128) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 146)\n  (:start . 139) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 151) (:start . 147)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 162)\n  (:start . 156) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 165) (:start . 163)\n  (:id . 70))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . "JJ") (:stem . "diverged") (:form . "diverged") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 185) (:start . 182)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 195)\n  (:start . 186) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 198) (:start . 196)\n  (:id . 75))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 205)\n  (:start . 199) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x6.207.1) (:span 163 165))\n  ((:id . :x6.207.2) (:span 109 122)) ((:id . :x6.207.3) (:span 105 108)))\n (:hscopes ((:id . :x6.207.1) (:span 139 205))\n  ((:id . :x6.207.2) (:span 109 205)) ((:id . :x6.207.3) (:span 105 205)))\n (:identifiers (:sid . :s6.207) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101947@unknown@formal@none@1@S@It is also worth noting that this portion corresponds to a separate exon in some teleosts (see Discussion).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "worth") (:form . "worth") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "note") (:form . "noting") (:end . 23) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 41)\n  (:start . 34) (:id . 49))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 72) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 80) (:start . 76)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "teleost") (:form . "teleosts") (:end . 89)\n  (:start . 81) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Discussion") (:form . "Discussion") (:end . 105)\n  (:start . 95) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.208) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101948@unknown@formal@none@1@S@The ring finger motif itself is also present in several sea urchin proteins unrelated to RAG1 but significantly similar to diverse proteins associated with immune and developmental systems as well as regulation of transcription.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 111) (:start . 98) (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 139)\n  (:start . 131) (:id . 63))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 150)\n  (:start . 140) (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 155) (:start . 151)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 180) (:start . 167) (:id . 68))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 188)\n  (:start . 181) (:id . 69))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 210)\n  (:start . 200) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 74))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 227) (:start . 214) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 228) (:start . 227)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s6.209) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101950@unknown@formal@none@1@S@Even without the finger, the remaining portions of the sea urchin sequences were significantly similar to the corresponding portions of RAG1.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 65)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 75)\n  (:start . 66) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 94) (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 123)\n  (:start . 110) (:id . 60))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x6.211.1) (:span 5 12)))\n (:nscopes ((:id . :x6.211.1) (:span 5 23)))\n (:identifiers (:sid . :s6.211) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101951@unknown@formal@none@1@S@BLASTP E-values were 9×10-9, 7×10-5, and 10-3 for the P5_SP, P4_SP, and 768_SP sequences, respectively; because both the low-complexity filter and composition-based statistics were applied, the corresponding E-values were estimated very conservatively.@(((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-values") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "CD") (:stem . "9×10-9") (:form . "9×10-9") (:end . 27)\n  (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 46))\n ((:tag . "CD") (:stem . "7×10-5") (:form . "7×10-5") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "CD") (:stem . "10-3") (:form . "10-3") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "P5_SP") (:form . "P5_SP") (:end . 59) (:start . 54)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "P4_SP") (:form . "P4_SP") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 57))\n ((:tag . "NN") (:stem . "768_sp") (:form . "768_SP") (:end . 78)\n  (:start . 72) (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 88)\n  (:start . 79) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 102)\n  (:start . 90) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 111)\n  (:start . 104) (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 116) (:start . 112)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "low-complexity") (:form . "low-complexity")\n  (:end . 135) (:start . 121) (:id . 66))\n ((:tag . "NN") (:stem . "filter") (:form . "filter") (:end . 142)\n  (:start . 136) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "composition-based") (:form . "composition-based")\n  (:end . 164) (:start . 147) (:id . 69))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 175)\n  (:start . 165) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 180) (:start . 176)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "apply") (:form . "applied") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 207)\n  (:start . 194) (:id . 75))\n ((:tag . "NNS") (:stem . "e-value") (:form . "E-values") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 221) (:start . 217)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 231)\n  (:start . 222) (:id . 78))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 236) (:start . 232)\n  (:id . 79))\n ((:tag . "RB") (:stem . "conservatively") (:form . "conservatively")\n  (:end . 251) (:start . 237) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s6.212) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101952@unknown@formal@none@1@S@BLASTP searches of the sea urchin sequences against all GenBank proteins, excluding RAG1, detected only the ring finger domain of the sea urchin sequences.@(((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 72)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "exclude") (:form . "excluding") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "detect") (:form . "detected") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 103) (:start . 99)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 112) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 119)\n  (:start . 113) (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 154)\n  (:start . 145) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 68)))@@@1@27@((:ncues ((:id . :x6.213.1) (:span 74 83)))\n (:nscopes ((:id . :x6.213.1) (:span 74 88)))\n (:identifiers (:sid . :s6.213) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101953@unknown@formal@none@1@S@E-values of these matches were much higher than the E-values of similarities to the RAG1 proteins (SP_768: 0.04 versus 7×10-7; SP_86231: 3·10-4 versus 7×10-7; SP_1226: 10-4 versus 2×10-7; P4_SP: 10 versus 2×10-7; P5_SP does not have ring finger and matches RAG1 only, E-value == 9×10-7).@(((:tag . "NNS") (:stem . "e-value") (:form . "E-values") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 42) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "e-value") (:form . "E-values") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 88) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "SP_768") (:form . "SP_768") (:end . 105)\n  (:start . 99) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 106) (:start . 105)\n  (:id . 60))\n ((:tag . "CD") (:stem . "0.04") (:form . "0.04") (:end . 111) (:start . 107)\n  (:id . 61))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . "CD") (:stem . "7×10-7") (:form . "7×10-7") (:end . 125)\n  (:start . 119) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "SP_86231") (:form . "SP_86231") (:end . 135)\n  (:start . 127) (:id . 65))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . "CD") (:stem . "3·10-4") (:form . "3·10-4") (:end . 143)\n  (:start . 137) (:id . 67))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "CD") (:stem . "7×10-7") (:form . "7×10-7") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "SP_1226") (:form . "SP_1226") (:end . 166)\n  (:start . 159) (:id . 71))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 167) (:start . 166)\n  (:id . 72))\n ((:tag . "CD") (:stem . "10-4") (:form . "10-4") (:end . 172) (:start . 168)\n  (:id . 73))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 179)\n  (:start . 173) (:id . 74))\n ((:tag . "CD") (:stem . "2×10-7") (:form . "2×10-7") (:end . 186)\n  (:start . 180) (:id . 75))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 187) (:start . 186)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "P4_SP") (:form . "P4_SP") (:end . 193)\n  (:start . 188) (:id . 77))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 194) (:start . 193)\n  (:id . 78))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 197) (:start . 195)\n  (:id . 79))\n ((:tag . "CC") (:stem . "versus") (:form . "versus") (:end . 204)\n  (:start . 198) (:id . 80))\n ((:tag . "CD") (:stem . "2×10-7") (:form . "2×10-7") (:end . 211)\n  (:start . 205) (:id . 81))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 212) (:start . 211)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "P5_SP") (:form . "P5_SP") (:end . 218)\n  (:start . 213) (:id . 83))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 223) (:start . 219)\n  (:id . 84))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 227) (:start . 224)\n  (:id . 85))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 232) (:start . 228)\n  (:id . 86))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 237) (:start . 233)\n  (:id . 87))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 244)\n  (:start . 238) (:id . 88))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 248) (:start . 245)\n  (:id . 89))\n ((:tag . "VBZ") (:stem . "match") (:form . "matches") (:end . 256)\n  (:start . 249) (:id . 90))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 261) (:start . 257)\n  (:id . 91))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 266) (:start . 262)\n  (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 267) (:start . 266)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 275)\n  (:start . 268) (:id . 94))\n ((:tag . "SYM") (:stem . "==") (:form . "==") (:end . 278) (:start . 276)\n  (:id . 95))\n ((:tag . "CD") (:stem . "9×10-7") (:form . "9×10-7") (:end . 285)\n  (:start . 279) (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 286) (:start . 285)\n  (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 287) (:start . 286)\n  (:id . 98)))@@@1@57@((:ncues ((:id . :x6.214.1) (:span 224 227)))\n (:nscopes ((:id . :x6.214.1) (:span 224 244)))\n (:identifiers (:sid . :s6.214) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101954@unknown@formal@none@1@S@Based on the same approach, our study found that the starlet sea anemone and hydra genomes also encode several families of the N-terminal RAG1 domain that appear to be separate from the RAG1 core–like proteins (data not shown).@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "approach") (:form . "approach") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 37) (:start . 32)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 43) (:start . 38)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 52))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 60)\n  (:start . 53) (:id . 53))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 72)\n  (:start . 65) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 82) (:start . 77)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 137)\n  (:start . 127) (:id . 65))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 161)\n  (:start . 155) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 164) (:start . 162)\n  (:id . 70))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 176)\n  (:start . 168) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 181) (:start . 177)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 185) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 190) (:start . 186)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 200)\n  (:start . 191) (:id . 76))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 209)\n  (:start . 201) (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 215)\n  (:start . 211) (:id . 79))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 225)\n  (:start . 220) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 226) (:start . 225)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x6.215.2) (:span 155 161)))\n (:ncues ((:id . :x6.215.1) (:span 216 219)))\n (:hscopes ((:id . :x6.215.2) (:span 150 209)))\n (:nscopes ((:id . :x6.215.1) (:span 216 226)))\n (:identifiers (:sid . :s6.215) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101955@unknown@formal@none@1@S@The only exception was the already mentioned sea anemone RAG1 core–like sequence.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBN") (:stem . "mention") (:form . "mentioned") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 61) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.216) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101956@unknown@formal@none@1@S@The approximately 90-aa N-terminus of the latter sequence is the ring finger (E < 10-7, multiple BLASTP matches against known ring fingers in GenBank).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "90-aa") (:form . "90-aa") (:end . 23) (:start . 18)\n  (:id . 44))\n ((:tag . "NN") (:stem . "n-terminus") (:form . "N-terminus") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 69) (:start . 65)\n  (:id . 52))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "<") (:form . "<") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CD") (:stem . "10-7") (:form . "10-7") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 96)\n  (:start . 88) (:id . 59))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 103)\n  (:start . 97) (:id . 60))\n ((:tag . "VBZ") (:stem . "match") (:form . "matches") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 125)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 130) (:start . 126)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "finger") (:form . "fingers") (:end . 138)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 149)\n  (:start . 142) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.217) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101957@unknown@formal@none@1@S@Multiple Alignment of the RAG1 N-Terminal Domain and Sea Urchin Protein Sequences@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "Alignment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "N-Terminal") (:form . "N-Terminal") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NNP") (:stem . "Domain") (:form . "Domain") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Urchin") (:form . "Urchin") (:end . 63)\n  (:start . 57) (:id . 51))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "NNP") (:stem . "Sequences") (:form . "Sequences") (:end . 81)\n  (:start . 72) (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.218) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5101958@unknown@formal@none@1@S@RAG1_HS, RAG1_PD, RAG1_SS, RAG1_RM, and RAG1_LM mark the human (GenBank accession number NP_000439), lungfish (AAS75810), pig (BAC54968), stripe-sided rhabdornis or Rhabdornis mysticalis bird (AAQ76078), and latimeria (AAS75807) proteins, respectively.@(((:tag . "NNP") (:stem . "RAG1_HS") (:form . "RAG1_HS") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "RAG1_PD") (:form . "RAG1_PD") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1_SS") (:form . "RAG1_SS") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1_RM") (:form . "RAG1_RM") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAG1_LM") (:form . "RAG1_LM") (:end . 47)\n  (:start . 40) (:id . 51))\n ((:tag . "VBP") (:stem . "mark") (:form . "mark") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 62) (:start . 57)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 71)\n  (:start . 64) (:id . 56))\n ((:tag . "NN") (:stem . "accession") (:form . "accession") (:end . 81)\n  (:start . 72) (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 88)\n  (:start . 82) (:id . 58))\n ((:tag . "NNP") (:stem . "NP_000439") (:form . "NP_000439") (:end . 98)\n  (:start . 89) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lungfish") (:form . "lungfish") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "AAS75810") (:form . "AAS75810") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 120) (:start . 119)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "pig") (:form . "pig") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 68))\n ((:tag . "NN") (:stem . "bac54968") (:form . "BAC54968") (:end . 135)\n  (:start . 127) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "stripe-sided") (:form . "stripe-sided") (:end . 150)\n  (:start . 138) (:id . 72))\n ((:tag . "NN") (:stem . "rhabdornis") (:form . "rhabdornis") (:end . 161)\n  (:start . 151) (:id . 73))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Rhabdornis") (:form . "Rhabdornis") (:end . 175)\n  (:start . 165) (:id . 75))\n ((:tag . "PRP$") (:stem . "mysticalis") (:form . "mysticalis") (:end . 186)\n  (:start . 176) (:id . 76))\n ((:tag . "NN") (:stem . "bird") (:form . "bird") (:end . 191) (:start . 187)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 193) (:start . 192)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "AAQ76078") (:form . "AAQ76078") (:end . 201)\n  (:start . 193) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 82))\n ((:tag . "NNS") (:stem . "latimeria") (:form . "latimeria") (:end . 217)\n  (:start . 208) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 84))\n ((:tag . "NN") (:stem . "aas75807") (:form . "AAS75807") (:end . 227)\n  (:start . 219) (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 86))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 237)\n  (:start . 229) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 88))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 251)\n  (:start . 239) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 252) (:start . 251)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s6.219) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101960@unknown@formal@none@1@S@Protein sequences assembled from the sea urchin and lancelet WGS Trace Archives are denoted as P4-P5_SP and P1-P5_BF, respectively.@(((:tag . "NN") (:stem . "protein") (:form . "Protein") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 17)\n  (:start . 8) (:id . 43))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "lancelet") (:form . "lancelet") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "NNP") (:stem . "WGS") (:form . "WGS") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "NNPS") (:stem . "Archives") (:form . "Archives") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "denote") (:form . "denoted") (:end . 91)\n  (:start . 84) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "P4-P5_SP") (:form . "P4-P5_SP") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "P1-P5_BF") (:form . "P1-P5_BF") (:end . 116)\n  (:start . 108) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 130)\n  (:start . 118) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.221) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101961@unknown@formal@none@1@S@Three conserved motifs are underlined and numbered.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 22)\n  (:start . 16) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "underline") (:form . "underlined") (:end . 37)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "number") (:form . "numbered") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.222) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101962@unknown@formal@none@1@S@The third conserved motif is known as the ring finger.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.223) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101963@unknown@formal@none@1@S@Distances from the protein N-termini are indicated by numbers.@(((:tag . "NNS") (:stem . "distance") (:form . "Distances") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "NNP") (:stem . "N-termini") (:form . "N-termini") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 62) (:start . 61)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.224) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101964@unknown@formal@none@1@S@Discussion@(((:tag . "NN") (:stem . "discussion") (:form . "Discussion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s6.225) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5101965@unknown@formal@none@1@S@The significant similarity between the Transib TPases and RAG1 core, the common structure of the Transib TIRs and RSSs, as well as the similar size of TSDs characterizing transpositions of Transib transposons and transpositions catalyzed by RAG1 and RAG2, directly support the 25-year-old hypothesis of a transposon-related origin of the V(D)J machinery.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 26)\n  (:start . 16) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 53) (:start . 47)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 89)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 104)\n  (:start . 97) (:id . 58))\n ((:tag . "NNPS") (:stem . "TIR") (:form . "TIRs") (:end . 109) (:start . 105)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NNPS") (:stem . "RSS") (:form . "RSSs") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 127) (:start . 123)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 142)\n  (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 155) (:start . 151)\n  (:id . 70))\n ((:tag . "VBG") (:stem . "characterize") (:form . "characterizing")\n  (:end . 170) (:start . 156) (:id . 71))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 185) (:start . 171) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 188) (:start . 186)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 196)\n  (:start . 189) (:id . 74))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 208)\n  (:start . 197) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 227) (:start . 213) (:id . 77))\n ((:tag . "VBN") (:stem . "catalyze") (:form . "catalyzed") (:end . 237)\n  (:start . 228) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 240) (:start . 238)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 245) (:start . 241)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 249) (:start . 246)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "RAG2") (:form . "RAG2") (:end . 254) (:start . 250)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 255) (:start . 254)\n  (:id . 83))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 264)\n  (:start . 256) (:id . 84))\n ((:tag . "VBP") (:stem . "support") (:form . "support") (:end . 272)\n  (:start . 265) (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 276) (:start . 273)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "25-year-old") (:form . "25-year-old") (:end . 288)\n  (:start . 277) (:id . 87))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 299)\n  (:start . 289) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 302) (:start . 300)\n  (:id . 89))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 304) (:start . 303)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "transposon-related") (:form . "transposon-related")\n  (:end . 323) (:start . 305) (:id . 91))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 330)\n  (:start . 324) (:id . 92))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 333) (:start . 331)\n  (:id . 93))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 337) (:start . 334)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 343)\n  (:start . 338) (:id . 95))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 353)\n  (:start . 344) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 354) (:start . 353)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s6.226) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101966@unknown@formal@none@1@S@Previously, the “RAG transposon” hypothesis was open to challenge by alternative models of convergent evolution.@(((:tag . "RB") (:stem . "previously") (:form . "Previously") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "RAG") (:form . "RAG") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 31)\n  (:start . 21) (:id . 47))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "open") (:form . "open") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "VB") (:stem . "challenge") (:form . "challenge") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "model") (:form . "models") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "convergent") (:form . "convergent") (:end . 101)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 111)\n  (:start . 102) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.227) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101967@unknown@formal@none@1@S@Because there were no known TPases similar to RAG1, it could be argued that RAG1 independently developed some TPase-like properties, rather than deriving them from a TE-encoded TPase [24].@(((:tag . "IN") (:stem . "because") (:form . "Because") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 34) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "argue") (:form . "argued") (:end . 70)\n  (:start . 64) (:id . 55))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "RB") (:stem . "independently") (:form . "independently")\n  (:end . 94) (:start . 81) (:id . 58))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "tpase-like") (:form . "TPase-like") (:end . 120)\n  (:start . 110) (:id . 61))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 131)\n  (:start . 121) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 139)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 144) (:start . 140)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "derive") (:form . "deriving") (:end . 153)\n  (:start . 145) (:id . 66))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 158) (:start . 154)\n  (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 165) (:start . 164)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "te-encoded") (:form . "TE-encoded") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 182)\n  (:start . 177) (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 184) (:start . 183)\n  (:id . 72))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 186) (:start . 184)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 187) (:start . 186)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x6.228.2) (:span 64 70)) ((:id . :x6.228.3) (:span 55 60)))\n (:ncues ((:id . :x6.228.1) (:span 133 144))\n  ((:id . :x6.228.4) (:span 19 21)))\n (:hscopes ((:id . :x6.228.2) (:span 64 182))\n  ((:id . :x6.228.3) (:span 55 182)))\n (:nscopes ((:id . :x6.228.1) (:span 133 182))\n  ((:id . :x6.228.4) (:span 19 50)))\n (:identifiers (:sid . :s6.228) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101968@unknown@formal@none@1@S@These arguments can now be put to rest.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "argument") (:form . "arguments") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "put") (:form . "put") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "VB") (:stem . "rest") (:form . "rest") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.229) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101970@unknown@formal@none@1@S@Furthermore, after its recruitment, the RAG1 core most likely went through a period of intensive transformations due to diversifying/positive selection, which further decreased its similarity to Transib TPase.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "recruitment") (:form . "recruitment") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 61)\n  (:start . 55) (:id . 52))\n ((:tag . "VBD") (:stem . "go") (:form . "went") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "intensive") (:form . "intensive") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "NNS") (:stem . "transformation") (:form . "transformations")\n  (:end . 112) (:start . 97) (:id . 59))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 116) (:start . 113)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "diversifying/positive")\n  (:form . "diversifying/positive") (:end . 141) (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 151)\n  (:start . 142) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 152) (:start . 151)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 158)\n  (:start . 153) (:id . 65))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "VBD") (:stem . "decrease") (:form . "decreased") (:end . 176)\n  (:start . 167) (:id . 67))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 191)\n  (:start . 181) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 202)\n  (:start . 195) (:id . 71))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 208)\n  (:start . 203) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x6.231.1) (:span 55 61)))\n (:hscopes ((:id . :x6.231.1) (:span 55 208)))\n (:identifiers (:sid . :s6.231) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101971@unknown@formal@none@1@S@Afterwards, the RAG1 genes continued to evolve at a slow and steady pace under stabilizing selection, as indicated by the observed conservation of the RAG1 core (79% identity between sharks and mammals).@(((:tag . "RB") (:stem . "afterwards") (:form . "Afterwards") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "continue") (:form . "continued") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VB") (:stem . "evolve") (:form . "evolve") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "slow") (:form . "slow") (:end . 56) (:start . 52)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "steady") (:form . "steady") (:end . 67)\n  (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "pace") (:form . "pace") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "stabilize") (:form . "stabilizing") (:end . 90)\n  (:start . 79) (:id . 57))\n ((:tag . "NN") (:stem . "selection") (:form . "selection") (:end . 100)\n  (:start . 91) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 143)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "CD") (:stem . "79") (:form . "79") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 174)\n  (:start . 166) (:id . 73))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 182)\n  (:start . 175) (:id . 74))\n ((:tag . "NNS") (:stem . "shark") (:form . "sharks") (:end . 189)\n  (:start . 183) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 201)\n  (:start . 194) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.232) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101972@unknown@formal@none@1@S@Some of the intermediate stages of RAG1 evolution can be inferred from analysis of the sea urchin in which RAG1-like proteins were recently observed [37], and from analysis of the lancelet, starlet sea anemone, and hydra genomes.@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "intermediate") (:form . "intermediate") (:end . 24)\n  (:start . 12) (:id . 45))\n ((:tag . "NNS") (:stem . "stage") (:form . "stages") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "infer") (:form . "inferred") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 79)\n  (:start . 71) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 97)\n  (:start . 91) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 106)\n  (:start . 101) (:id . 60))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 116)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 148)\n  (:start . 140) (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 152) (:start . 150)\n  (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 153) (:start . 152)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 71))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 172)\n  (:start . 164) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 188)\n  (:start . 180) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 76))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 197)\n  (:start . 190) (:id . 77))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 201) (:start . 198)\n  (:id . 78))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 209)\n  (:start . 202) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 210) (:start . 209)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 214) (:start . 211)\n  (:id . 81))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 220)\n  (:start . 215) (:id . 82))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 228)\n  (:start . 221) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x6.233.1) (:span 57 65)))\n (:hscopes ((:id . :x6.233.1) (:span 0 228)))\n (:identifiers (:sid . :s6.233) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101973@unknown@formal@none@1@S@Based on the presence of stop codons disrupting some of the RAG1-like sequences, it has been suggested [37] that the sea urchin sequences represent remnants of transposable elements.@(((:tag . "VBN") (:stem . "base") (:form . "Based") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "stop") (:form . "stop") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "codon") (:form . "codons") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "VBG") (:stem . "disrupt") (:form . "disrupting") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 104) (:start . 103)\n  (:id . 60))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 106) (:start . 104)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 107) (:start . 106)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 120) (:start . 117)\n  (:id . 65))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 127)\n  (:start . 121) (:id . 66))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 137)\n  (:start . 128) (:id . 67))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 147)\n  (:start . 138) (:id . 68))\n ((:tag . "NNS") (:stem . "remnant") (:form . "remnants") (:end . 156)\n  (:start . 148) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "transposable") (:form . "transposable") (:end . 172)\n  (:start . 160) (:id . 71))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 181)\n  (:start . 173) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x6.234.1) (:span 93 102)))\n (:hscopes ((:id . :x6.234.1) (:span 93 181)))\n (:identifiers (:sid . :s6.234) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101974@unknown@formal@none@1@S@Typically, TPase-coding autonomous DNA transposons are present in only a few complete copies per genome.@(((:tag . "RB") (:stem . "typically") (:form . "Typically") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "tpase-coding") (:form . "TPase-coding") (:end . 23)\n  (:start . 11) (:id . 44))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 34)\n  (:start . 24) (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 50)\n  (:start . 39) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 62)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 70) (:start . 66)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 85)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 92) (:start . 86)\n  (:id . 55))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.235) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101975@unknown@formal@none@1@S@At the same time, sequences homologous to their terminal portions, including specific TIRs, are usually abundant due to the proliferation of nonautonomous DNA transposons fueled by the TPase expressed by the corresponding low-copy autonomous elements.@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 27)\n  (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 47)\n  (:start . 42) (:id . 50))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 56)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 65)\n  (:start . 57) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 76)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 103)\n  (:start . 96) (:id . 59))\n ((:tag . "JJ") (:stem . "abundant") (:form . "abundant") (:end . 112)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 63))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 137) (:start . 124) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "nonautonomous") (:form . "nonautonomous")\n  (:end . 154) (:start . 141) (:id . 66))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 158) (:start . 155)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 170)\n  (:start . 159) (:id . 68))\n ((:tag . "VBN") (:stem . "fuel") (:form . "fueled") (:end . 177)\n  (:start . 171) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 180) (:start . 178)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 71))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 190)\n  (:start . 185) (:id . 72))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 203) (:start . 201)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 207) (:start . 204)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 221)\n  (:start . 208) (:id . 76))\n ((:tag . "JJ") (:stem . "low-copy") (:form . "low-copy") (:end . 230)\n  (:start . 222) (:id . 77))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 241)\n  (:start . 231) (:id . 78))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 250)\n  (:start . 242) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s6.236) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101976@unknown@formal@none@1@S@Therefore, even if only 30% of the sea urchin genome has been sequenced to date, it is expected that the regions flanking the TPase portions of potential autonomous elements should be similar to numerous nonautonomous elements.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 27) (:start . 26)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 45)\n  (:start . 39) (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 61) (:start . 57)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 71)\n  (:start . 62) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 83) (:start . 81)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 95)\n  (:start . 87) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 112)\n  (:start . 105) (:id . 65))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 121)\n  (:start . 113) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 67))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 131)\n  (:start . 126) (:id . 68))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 140)\n  (:start . 132) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 153)\n  (:start . 144) (:id . 71))\n ((:tag . "JJ") (:stem . "autonomous") (:form . "autonomous") (:end . 164)\n  (:start . 154) (:id . 72))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 173)\n  (:start . 165) (:id . 73))\n ((:tag . "MD") (:stem . "should") (:form . "should") (:end . 180)\n  (:start . 174) (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 183) (:start . 181)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 191)\n  (:start . 184) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 203)\n  (:start . 195) (:id . 78))\n ((:tag . "JJ") (:stem . "nonautonomous") (:form . "nonautonomous")\n  (:end . 217) (:start . 204) (:id . 79))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 226)\n  (:start . 218) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x6.237.1) (:span 174 180))\n  ((:id . :x6.237.2) (:span 87 95)))\n (:hscopes ((:id . :x6.237.1) (:span 174 226))\n  ((:id . :x6.237.2) (:span 87 226)))\n (:identifiers (:sid . :s6.237) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101977@unknown@formal@none@1@S@So far, we have found no evidence of such similarities.@(((:tag . "RB") (:stem . "so") (:form . "So") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 15) (:start . 11)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 21) (:start . 16)\n  (:id . 47))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 24) (:start . 22)\n  (:id . 48))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 33)\n  (:start . 25) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 41) (:start . 37)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 54)\n  (:start . 42) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 55) (:start . 54)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x6.238.1) (:span 22 24)))\n (:nscopes ((:id . :x6.238.1) (:span 22 54)))\n (:identifiers (:sid . :s6.238) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101978@unknown@formal@none@1@S@Detailed analysis of regions flanking the sea urchin RAG1-like DNA coding sequences revealed a variety of different transposable elements inserted in the proximity of the coding sequences (see Figure 5).@(((:tag . "JJ") (:stem . "detailed") (:form . "Detailed") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 37)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 52)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "coding") (:form . "coding") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBD") (:stem . "reveal") (:form . "revealed") (:end . 92)\n  (:start . 84) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "NN") (:stem . "variety") (:form . "variety") (:end . 102)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 115)\n  (:start . 106) (:id . 58))\n ((:tag . "JJ") (:stem . "transposable") (:form . "transposable") (:end . 128)\n  (:start . 116) (:id . 59))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 137)\n  (:start . 129) (:id . 60))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "NN") (:stem . "proximity") (:form . "proximity") (:end . 163)\n  (:start . 154) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "cod") (:form . "coding") (:end . 177)\n  (:start . 171) (:id . 67))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 187)\n  (:start . 178) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 192) (:start . 189)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 199)\n  (:start . 193) (:id . 71))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 201) (:start . 200)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 202) (:start . 201)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.239) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101980@unknown@formal@none@1@S@We also could not identify the 5-bp TSDs and TIRs characteristic of the Transib superfamily.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "5-bp") (:form . "5-bp") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NNPS") (:stem . "TSD") (:form . "TSDs") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNPS") (:stem . "TIR") (:form . "TIRs") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "characteristic") (:form . "characteristic")\n  (:end . 64) (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 79)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 91)\n  (:start . 80) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:ncues ((:id . :x6.241.1) (:span 14 17)))\n (:nscopes ((:id . :x6.241.1) (:span 14 91)))\n (:identifiers (:sid . :s6.241) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101981@unknown@formal@none@1@S@Still, given that only one third of the sea urchin genome is currently assembled as a set of contigs longer than several thousand nucleotides (the remaining portion is represented by short WGS sequences), we cannot rule out the possibility that the sea urchin RAG1-like proteins are remnants of an unknown branch of Transib transposons.@(((:tag . "RB") (:stem . "still") (:form . "Still") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "third") (:form . "third") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 43) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 70)\n  (:start . 61) (:id . 55))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 100)\n  (:start . 93) (:id . 61))\n ((:tag . "RBR") (:stem . "longer") (:form . "longer") (:end . 107)\n  (:start . 101) (:id . 62))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 112) (:start . 108)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 120)\n  (:start . 113) (:id . 64))\n ((:tag . "CD") (:stem . "thousand") (:form . "thousand") (:end . 129)\n  (:start . 121) (:id . 65))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 141)\n  (:start . 130) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 156)\n  (:start . 147) (:id . 69))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 164)\n  (:start . 157) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 167) (:start . 165)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 179)\n  (:start . 168) (:id . 72))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 188)\n  (:start . 183) (:id . 74))\n ((:tag . "NNP") (:stem . "WGS") (:form . "WGS") (:end . 192) (:start . 189)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 202)\n  (:start . 193) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 78))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 207) (:start . 205)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "cannot") (:form . "cannot") (:end . 214)\n  (:start . 208) (:id . 80))\n ((:tag . "VB") (:stem . "rule") (:form . "rule") (:end . 219) (:start . 215)\n  (:id . 81))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 223) (:start . 220)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 83))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 239)\n  (:start . 228) (:id . 84))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 244) (:start . 240)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 248) (:start . 245)\n  (:id . 86))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 252) (:start . 249)\n  (:id . 87))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 259)\n  (:start . 253) (:id . 88))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 269)\n  (:start . 260) (:id . 89))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 278)\n  (:start . 270) (:id . 90))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 282) (:start . 279)\n  (:id . 91))\n ((:tag . "NNS") (:stem . "remnant") (:form . "remnants") (:end . 291)\n  (:start . 283) (:id . 92))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 294) (:start . 292)\n  (:id . 93))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 297) (:start . 295)\n  (:id . 94))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 305)\n  (:start . 298) (:id . 95))\n ((:tag . "NN") (:stem . "branch") (:form . "branch") (:end . 312)\n  (:start . 306) (:id . 96))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 315) (:start . 313)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 323)\n  (:start . 316) (:id . 98))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 335)\n  (:start . 324) (:id . 99))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 336) (:start . 335)\n  (:id . 100)))@@@1@59@((:hcues ((:id . :x6.242.1) (:span 208 239)))\n (:hscopes ((:id . :x6.242.1) (:span 208 335)))\n (:identifiers (:sid . :s6.242) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101982@unknown@formal@none@1@S@Given that the genomes of lancelet, hydra, and starlet sea anemone are currently available only as unassembled WGS traces, the question whether the corresponding RAG1-like sequences are remnants of transposons or genes/pseudogenes must be left open.@(((:tag . "VBN") (:stem . "give") (:form . "Given") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 66)\n  (:start . 59) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 80)\n  (:start . 71) (:id . 56))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 90)\n  (:start . 81) (:id . 57))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "unassembled") (:form . "unassembled") (:end . 110)\n  (:start . 99) (:id . 60))\n ((:tag . "NN") (:stem . "wgs") (:form . "WGS") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "trace") (:form . "traces") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 135)\n  (:start . 127) (:id . 65))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 161)\n  (:start . 148) (:id . 68))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 171)\n  (:start . 162) (:id . 69))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 181)\n  (:start . 172) (:id . 70))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "remnant") (:form . "remnants") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 197) (:start . 195)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 209)\n  (:start . 198) (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 212) (:start . 210)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "genes/pseudogene") (:form . "genes/pseudogenes")\n  (:end . 230) (:start . 213) (:id . 76))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 235) (:start . 231)\n  (:id . 77))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 238) (:start . 236)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "leave") (:form . "left") (:end . 243)\n  (:start . 239) (:id . 79))\n ((:tag . "RP") (:stem . "open") (:form . "open") (:end . 248) (:start . 244)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 249) (:start . 248)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x6.243.1) (:span 136 143))\n  ((:id . :x6.243.2) (:span 127 135 231 248)))\n (:hscopes ((:id . :x6.243.1) (:span 136 230))\n  ((:id . :x6.243.2) (:span 127 248)))\n (:identifiers (:sid . :s6.243) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101983@unknown@formal@none@1@S@The alternative possibility is that the sea urchin RAG1 core–like sequences represent diverse genes and pseudogenes that belong to a rapidly evolving multigene family.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "alternative") (:form . "alternative") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 27)\n  (:start . 16) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 85)\n  (:start . 76) (:id . 53))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 93)\n  (:start . 86) (:id . 54))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 99) (:start . 94)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "pseudogene") (:form . "pseudogenes") (:end . 115)\n  (:start . 104) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 120) (:start . 116)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 140)\n  (:start . 133) (:id . 62))\n ((:tag . "VBG") (:stem . "evolve") (:form . "evolving") (:end . 149)\n  (:start . 141) (:id . 63))\n ((:tag . "JJ") (:stem . "multigene") (:form . "multigene") (:end . 159)\n  (:start . 150) (:id . 64))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 166)\n  (:start . 160) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x6.244.1) (:span 16 27)))\n (:hscopes ((:id . :x6.244.1) (:span 16 166)))\n (:identifiers (:sid . :s6.244) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101984@unknown@formal@none@1@S@This opens the tantalizing possibility that the RAG1 core was recruited from a Transib TPase in a common ancestor of Bilaterians and Cnidarians, and subsequently lost in nematodes, insects, and sea squirts (see Figure 1).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "open") (:form . "opens") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "tantalize") (:form . "tantalizing") (:end . 26)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 38)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 76) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 104)\n  (:start . 98) (:id . 59))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 113)\n  (:start . 105) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NNPS") (:stem . "Bilaterian") (:form . "Bilaterians") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NNPS") (:stem . "Cnidarian") (:form . "Cnidarians") (:end . 143)\n  (:start . 133) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "RB") (:stem . "subsequently") (:form . "subsequently") (:end . 161)\n  (:start . 149) (:id . 67))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "nematode") (:form . "nematodes") (:end . 179)\n  (:start . 170) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "insect") (:form . "insects") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 74))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 197) (:start . 194)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "squirt") (:form . "squirts") (:end . 205)\n  (:start . 198) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 207) (:start . 206)\n  (:id . 77))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 210) (:start . 207)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 217)\n  (:start . 211) (:id . 79))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 220) (:start . 219)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x6.245.1) (:span 27 38)))\n (:hscopes ((:id . :x6.245.1) (:span 27 205)))\n (:identifiers (:sid . :s6.245) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101985@unknown@formal@none@1@S@Furthermore, given that the sea urchin, lancelet, hydra, and starlet sea anemone genomes harbor several highly divergent N-terminal–like domains, separate from the RAG1 core–like sequences and known transposable elements, it is very likely that the N-terminal–like domains of RAG1 also form a multigene family that can be traced back to a common ancestor of Deuterostomes (see Figure 1).@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . 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"is") (:end . 227) (:start . 225)\n  (:id . 78))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 239)\n  (:start . 233) (:id . 80))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 244) (:start . 240)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 248) (:start . 245)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "n-terminal–like") (:form . "N-terminal–like")\n  (:end . 264) (:start . 249) (:id . 83))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 272)\n  (:start . 265) (:id . 84))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 275) (:start . 273)\n  (:id . 85))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 280) (:start . 276)\n  (:id . 86))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 285) (:start . 281)\n  (:id . 87))\n ((:tag . "VBP") (:stem . "form") (:form . 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"JJ") (:stem . "common") (:form . "common") (:end . 345)\n  (:start . 339) (:id . 99))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 354)\n  (:start . 346) (:id . 100))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 357) (:start . 355)\n  (:id . 101))\n ((:tag . "NNP") (:stem . "Deuterostome") (:form . "Deuterostomes")\n  (:end . 371) (:start . 358) (:id . 102))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 373) (:start . 372)\n  (:id . 103))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 376) (:start . 373)\n  (:id . 104))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 383)\n  (:start . 377) (:id . 105))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 385) (:start . 384)\n  (:id . 106))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 386) (:start . 385)\n  (:id . 107))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 387) (:start . 386)\n  (:id . 108)))@@@1@67@((:hcues ((:id . :x6.246.1) (:span 233 239)))\n (:hscopes ((:id . :x6.246.1) (:span 233 371)))\n (:identifiers (:sid . :s6.246) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101986@unknown@formal@none@1@S@If so, then both N-terminal and core domains of RAG1 might have been derived from different genes present in a common ancestor of Deuterostomes.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 11) (:start . 7)\n  (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 16) (:start . 12)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 27)\n  (:start . 17) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 44)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 91)\n  (:start . 82) (:id . 58))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 97) (:start . 92)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 117)\n  (:start . 111) (:id . 63))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 126)\n  (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 129) (:start . 127)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Deuterostome") (:form . "Deuterostomes")\n  (:end . 143) (:start . 130) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x6.247.1) (:span 53 58)))\n (:hscopes ((:id . :x6.247.1) (:span 12 143)))\n (:identifiers (:sid . :s6.247) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101987@unknown@formal@none@1@S@Alternatively, the N-terminal domain of RAG1 might have been derived from a separate, unknown transposon.@(((:tag . "RB") (:stem . "alternatively") (:form . "Alternatively")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 36)\n  (:start . 30) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 50) (:start . 45)\n  (:id . 49))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "derive") (:form . "derived") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 75) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 105) (:start . 104)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x6.248.1) (:span 45 50)))\n (:hscopes ((:id . :x6.248.1) (:span 15 104)))\n (:identifiers (:sid . :s6.248) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101988@unknown@formal@none@1@S@The N-terminal domain of RAG1 has long been viewed as distinct from the core domain due to its lack of direct involvement in the V(D)J recombination reaction.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "RB") (:stem . "long") (:form . "long") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "view") (:form . "viewed") (:end . 50) (:start . 44)\n  (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 62)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 99) (:start . 95)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 109)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "involvement") (:form . "involvement") (:end . 121)\n  (:start . 110) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 134)\n  (:start . 129) (:id . 66))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 148) (:start . 135) (:id . 67))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x6.249.1) (:span 95 99)))\n (:nscopes ((:id . :x6.249.1) (:span 95 157)))\n (:identifiers (:sid . :s6.249) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101990@unknown@formal@none@1@S@The only notable exception is the anemone RAG1 core–like protein sequence, which is capped by the 90-aa ring finger motif.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "notable") (:form . "notable") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "exception") (:form . "exception") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 56)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 64)\n  (:start . 57) (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "cap") (:form . "capped") (:end . 90) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "90-aa") (:form . "90-aa") (:end . 103) (:start . 98)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 108) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 122) (:start . 121)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.251) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101991@unknown@formal@none@1@S@Taken together with the fact that only the RAG1 core is significantly similar to Transib TPase, the data suggest that the vertebrate RAG1 represents a fusion of once separate proteins.@(((:tag . "VBN") (:stem . "take") (:form . "Taken") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 69) (:start . 56) (:id . 53))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "VB") (:stem . "transib") (:form . "Transib") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 104)\n  (:start . 100) (:id . 60))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 132)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "represent") (:form . "represents") (:end . 148)\n  (:start . 138) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 157)\n  (:start . 151) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "RB") (:stem . "once") (:form . "once") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 174)\n  (:start . 166) (:id . 71))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 183)\n  (:start . 175) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x6.252.1) (:span 105 112)))\n (:hscopes ((:id . :x6.252.1) (:span 105 183)))\n (:identifiers (:sid . :s6.252) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101992@unknown@formal@none@1@S@This is consistent with the observation that in teleosts, (bony fish) the RAG1 gene is divided into exons by either one or two introns.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 39)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "teleost") (:form . "teleosts") (:end . 56)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "bony") (:form . "bony") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 86) (:start . 84)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 94)\n  (:start . 87) (:id . 60))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 99) (:start . 95)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 105)\n  (:start . 100) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 63))\n ((:tag . "DT") (:stem . "either") (:form . "either") (:end . 115)\n  (:start . 109) (:id . 64))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 122) (:start . 120)\n  (:id . 66))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 126) (:start . 123)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "intron") (:form . "introns") (:end . 134)\n  (:start . 127) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x6.253.1) (:span 109 115 120 122)))\n (:hscopes ((:id . :x6.253.1) (:span 109 126)))\n (:identifiers (:sid . :s6.253) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101993@unknown@formal@none@1@S@As a result, the RAG1 core is split into separate exons at the aa position that corresponds to position 460 in the human RAG1gene [29,34,38].@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 4) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 26) (:start . 22)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "split") (:form . "split") (:end . 35) (:start . 30)\n  (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 40) (:start . 36)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 49)\n  (:start . 41) (:id . 52))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 55) (:start . 50)\n  (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 58) (:start . 56)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 65) (:start . 63)\n  (:id . 56))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 74)\n  (:start . 66) (:id . 57))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 91)\n  (:start . 80) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 103)\n  (:start . 95) (:id . 61))\n ((:tag . "CD") (:stem . "460") (:form . "460") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 120)\n  (:start . 115) (:id . 65))\n ((:tag . "NNP") (:stem . "RAG1gene") (:form . "RAG1gene") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "CD") (:stem . "29,34,38") (:form . "29,34,38") (:end . 139)\n  (:start . 131) (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.254) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101994@unknown@formal@none@1@S@The core-like sequences encoded by the sea urchin WGS sequence contigs 29068 and 12509 correspond to either the second or third RAG1 exon in teleosts (depending on the number of introns), which is remarkably consistent with the fusion model.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "core-like") (:form . "core-like") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 49)\n  (:start . 43) (:id . 49))\n ((:tag . "VBZ") (:stem . "wgs") (:form . "WGS") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "CD") (:stem . "29068") (:form . "29068") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 54))\n ((:tag . "CD") (:stem . "12509") (:form . "12509") (:end . 86) (:start . 81)\n  (:id . 55))\n ((:tag . "VBP") (:stem . "correspond") (:form . "correspond") (:end . 97)\n  (:start . 87) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 57))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 127)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "teleost") (:form . "teleosts") (:end . 149)\n  (:start . 141) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "depend") (:form . "depending") (:end . 160)\n  (:start . 151) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 174)\n  (:start . 168) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "intron") (:form . "introns") (:end . 185)\n  (:start . 178) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 186) (:start . 185)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 75))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 193)\n  (:start . 188) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 196) (:start . 194)\n  (:id . 77))\n ((:tag . "RB") (:stem . "remarkably") (:form . "remarkably") (:end . 207)\n  (:start . 197) (:id . 78))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 218)\n  (:start . 208) (:id . 79))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 223) (:start . 219)\n  (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 81))\n ((:tag . "NN") (:stem . "fusion") (:form . "fusion") (:end . 234)\n  (:start . 228) (:id . 82))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 240)\n  (:start . 235) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x6.255.1) (:span 101 107 119 121)))\n (:hscopes ((:id . :x6.255.1) (:span 101 127)))\n (:identifiers (:sid . :s6.255) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101995@unknown@formal@none@1@S@The same model predicts that the N-terminal domain of RAG1 could also be assembled from two separate domains based on the presence of the second intron in some teleosts, splitting the N-terminal domain into the 102-aa N-terminal subdomain and the rest [34].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "predict") (:form . "predicts") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 58) (:start . 54)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 108)\n  (:start . 101) (:id . 59))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 117) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 133) (:start . 131)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 151)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "teleost") (:form . "teleosts") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "split") (:form . "splitting") (:end . 179)\n  (:start . 170) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 194)\n  (:start . 184) (:id . 74))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 201)\n  (:start . 195) (:id . 75))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 206) (:start . 202)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "102-aa") (:form . "102-aa") (:end . 217)\n  (:start . 211) (:id . 78))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 228)\n  (:start . 218) (:id . 79))\n ((:tag . "NN") (:stem . "subdomain") (:form . "subdomain") (:end . 238)\n  (:start . 229) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 242) (:start . 239)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 246) (:start . 243)\n  (:id . 82))\n ((:tag . "NN") (:stem . "rest") (:form . "rest") (:end . 251) (:start . 247)\n  (:id . 83))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 253) (:start . 252)\n  (:id . 84))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 255) (:start . 253)\n  (:id . 85))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 256) (:start . 255)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x6.256.1) (:span 59 64)))\n (:hscopes ((:id . :x6.256.1) (:span 29 251)))\n (:identifiers (:sid . :s6.256) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101996@unknown@formal@none@1@S@As indicated above, this subdomain, corresponding to the first exon in the genes split by two introns, appears to be missing in the sea urchin, lancelet, hydra, and starlet sea anemone N-terminal–like proteins.@(((:tag . "IN") (:stem . "as") (:form . "As") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "RB") (:stem . "above") (:form . "above") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subdomain") (:form . "subdomain") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 49)\n  (:start . 36) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "split") (:form . "split") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "intron") (:form . "introns") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 116) (:start . 114)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "miss") (:form . "missing") (:end . 124)\n  (:start . 117) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 127) (:start . 125)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 135) (:start . 132)\n  (:id . 68))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 142)\n  (:start . 136) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 70))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 152)\n  (:start . 144) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 72))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 159)\n  (:start . 154) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 160) (:start . 159)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 75))\n ((:tag . "NN") (:stem . "starlet") (:form . "starlet") (:end . 172)\n  (:start . 165) (:id . 76))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 176) (:start . 173)\n  (:id . 77))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 184)\n  (:start . 177) (:id . 78))\n ((:tag . "JJ") (:stem . "n-terminal–like") (:form . "N-terminal–like")\n  (:end . 200) (:start . 185) (:id . 79))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 209)\n  (:start . 201) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x6.257.1) (:span 103 110)))\n (:hscopes ((:id . :x6.257.1) (:span 20 209)))\n (:identifiers (:sid . :s6.257) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101997@unknown@formal@none@1@S@It may be encoded by a separate exon that is difficult to detect given its short length and the high level of sequence divergence between these species and vertebrates, or it might have been added in vertebrates.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 36) (:start . 32)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 41) (:start . 37)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 54)\n  (:start . 45) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "VB") (:stem . "detect") (:form . "detect") (:end . 64)\n  (:start . 58) (:id . 54))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 70) (:start . 65)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 80) (:start . 75)\n  (:id . 57))\n ((:tag . "NN") (:stem . "length") (:form . "length") (:end . 87)\n  (:start . 81) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 106)\n  (:start . 101) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 118)\n  (:start . 110) (:id . 64))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 129)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 143)\n  (:start . 138) (:id . 67))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 151)\n  (:start . 144) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 167)\n  (:start . 156) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 174) (:start . 172)\n  (:id . 73))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 180)\n  (:start . 175) (:id . 74))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 185) (:start . 181)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 196) (:start . 191)\n  (:id . 77))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 199) (:start . 197)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 211)\n  (:start . 200) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x6.258.1) (:span 175 180))\n  ((:id . :x6.258.3) (:span 169 171)) ((:id . :x6.258.2) (:span 3 6)))\n (:hscopes ((:id . :x6.258.1) (:span 172 211))\n  ((:id . :x6.258.3) (:span 0 167)) ((:id . :x6.258.2) (:span 0 211)))\n (:identifiers (:sid . :s6.258) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5101998@unknown@formal@none@1@S@Similarly, the RAG1 core–like protein in the sea urchin genome is shorter in its N-terminal part than the core domain in vertebrates and the corresponding Transib TPase.@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "core–like") (:form . "core–like") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJR") (:stem . "short") (:form . "shorter") (:end . 73)\n  (:start . 66) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 91)\n  (:start . 81) (:id . 57))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 96) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 101) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 132)\n  (:start . 121) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 154)\n  (:start . 141) (:id . 67))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 162)\n  (:start . 155) (:id . 68))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.259) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102000@unknown@formal@none@1@S@It is currently believed that both RAG1 and RAG2 proteins were originally encoded by the same transposon recruited in a common ancestor of jawed vertebrates [3,12,13,16].@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "currently") (:form . "currently") (:end . 15)\n  (:start . 6) (:id . 44))\n ((:tag . "VBN") (:stem . "believe") (:form . "believed") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 57)\n  (:start . 49) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "RB") (:stem . "originally") (:form . "originally") (:end . 73)\n  (:start . 63) (:id . 53))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 93) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 104)\n  (:start . 94) (:id . 58))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 114)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 119) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 126)\n  (:start . 120) (:id . 62))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 135)\n  (:start . 127) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "jaw") (:form . "jawed") (:end . 144) (:start . 139)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 156)\n  (:start . 145) (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 158) (:start . 157)\n  (:id . 67))\n ((:tag . "CD") (:stem . "3,12,13,16") (:form . "3,12,13,16") (:end . 168)\n  (:start . 158) (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x6.261.1) (:span 16 24)))\n (:hscopes ((:id . :x6.261.1) (:span 16 156)))\n (:identifiers (:sid . :s6.261) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102001@unknown@formal@none@1@S@However, none of the Transib transposons identified so far encode any proteins other than the Transib/RAG TPase.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 40)\n  (:start . 29) (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 84) (:start . 79)\n  (:id . 55))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Transib/RAG") (:form . "Transib/RAG") (:end . 105)\n  (:start . 94) (:id . 58))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x6.262.1) (:span 9 13)))\n (:nscopes ((:id . :x6.262.1) (:span 9 111)))\n (:identifiers (:sid . :s6.262) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102002@unknown@formal@none@1@S@Also, we could not find any RAG2-like sequences in the recently sequenced sea urchin, lancelet, hydra, and sea anemone genomes, which encode RAG1-like sequences.@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 14) (:start . 9)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "VB") (:stem . "find") (:form . "find") (:end . 23) (:start . 19)\n  (:id . 47))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "rag2-like") (:form . "RAG2-like") (:end . 37)\n  (:start . 28) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 47)\n  (:start . 38) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 94)\n  (:start . 86) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 101) (:start . 96)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 106) (:start . 103)\n  (:id . 62))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 118)\n  (:start . 111) (:id . 64))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 126)\n  (:start . 119) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 133)\n  (:start . 128) (:id . 67))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 140)\n  (:start . 134) (:id . 68))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 150)\n  (:start . 141) (:id . 69))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 160)\n  (:start . 151) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 71)))@@@1@30@((:ncues ((:id . :x6.263.1) (:span 15 18)))\n (:nscopes ((:id . :x6.263.1) (:span 15 160)))\n (:identifiers (:sid . :s6.263) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102003@unknown@formal@none@1@S@Autonomous DNA transposons from the MuDR, Harbinger, and En/Spm superfamilies are each known to encode a second regulatory protein [23,24], whereas some transposons from these superfamilies encode the TPase only.@(((:tag . "JJ") (:stem . "autonomous") (:form . "Autonomous") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MuDR") (:form . "MuDR") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Harbinger") (:form . "Harbinger") (:end . 51)\n  (:start . 42) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "En/Spm") (:form . "En/Spm") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies") (:end . 77)\n  (:start . 64) (:id . 53))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 81) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 92) (:start . 87)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 122)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "CD") (:stem . "23,24") (:form . "23,24") (:end . 137)\n  (:start . 132) (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 138) (:start . 137)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 66))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 147)\n  (:start . 140) (:id . 67))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 152) (:start . 148)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 164)\n  (:start . 153) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 175)\n  (:start . 170) (:id . 71))\n ((:tag . "NNS") (:stem . "superfamily") (:form . "superfamilies")\n  (:end . 189) (:start . 176) (:id . 72))\n ((:tag . "VBP") (:stem . "encode") (:form . "encode") (:end . 196)\n  (:start . 190) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "NN") (:stem . "tpase") (:form . "TPase") (:end . 206)\n  (:start . 201) (:id . 75))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 211) (:start . 207)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 212) (:start . 211)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s6.264) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102004@unknown@formal@none@1@S@Therefore, it is in principle possible that an ancient vertebrate Transib that was a direct ancestor of the RAG1 core also encoded a second protein, the direct ancestor of RAG2.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "principle") (:form . "principle") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "ancient") (:form . "ancient") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 65)\n  (:start . 55) (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 73)\n  (:start . 66) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "encode") (:form . "encoded") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 139)\n  (:start . 133) (:id . 66))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 147)\n  (:start . 140) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 159)\n  (:start . 153) (:id . 70))\n ((:tag . "NN") (:stem . "ancestor") (:form . "ancestor") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 176) (:start . 172)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 177) (:start . 176)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x6.265.1) (:span 30 38)))\n (:hscopes ((:id . :x6.265.1) (:span 30 176)))\n (:identifiers (:sid . :s6.265) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102005@unknown@formal@none@1@S@Nevertheless, the apparent lack of RAG2-like proteins in the sequenced portion of the sea urchin, lancelet, hydra, and sea anemone genomes, as well as in Transib transposons suggests that RAG2 was introduced in a separate event in jawless vertebrates.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "rag2-like") (:form . "RAG2-like") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 53)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 89) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 106)\n  (:start . 98) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hydra") (:form . "hydra") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "anemone") (:form . "anemone") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 138)\n  (:start . 131) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 161)\n  (:start . 154) (:id . 72))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 173)\n  (:start . 162) (:id . 73))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 182)\n  (:start . 174) (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 187) (:start . 183)\n  (:id . 75))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 196) (:start . 193)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 207)\n  (:start . 197) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 79))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 212) (:start . 211)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "separate") (:form . "separate") (:end . 221)\n  (:start . 213) (:id . 81))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 227)\n  (:start . 222) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 230) (:start . 228)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "jawless") (:form . "jawless") (:end . 238)\n  (:start . 231) (:id . 84))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 250)\n  (:start . 239) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x6.266.1) (:span 174 182))\n  ((:id . :x6.266.3) (:span 18 26)))\n (:ncues ((:id . :x6.266.2) (:span 27 31)))\n (:hscopes ((:id . :x6.266.1) (:span 174 250))\n  ((:id . :x6.266.3) (:span 18 173)))\n (:nscopes ((:id . :x6.266.2) (:span 27 173)))\n (:identifiers (:sid . :s6.266) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102006@unknown@formal@none@1@S@However, given the low 30% identity between the RAG1 and sea urchin/lancelet/sea squirt RAG1-like proteins, we cannot exclude the possibility that the ancestral RAG2 protein went through a period of strong diversification driven by positive selection, and it can no longer be identified by sequence comparisons but may still be present in invertebrates.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 26) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 35)\n  (:start . 27) (:id . 49))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 43)\n  (:start . 36) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "urchin/lancelet/sea")\n  (:form . "urchin/lancelet/sea") (:end . 80) (:start . 61) (:id . 55))\n ((:tag . "VBP") (:stem . "squirt") (:form . "squirt") (:end . 87)\n  (:start . 81) (:id . 56))\n ((:tag . "JJ") (:stem . "rag1-like") (:form . "RAG1-like") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 106)\n  (:start . 98) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "VB") (:stem . "exclude") (:form . "exclude") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 141)\n  (:start . 130) (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 146) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ancestral") (:form . "ancestral") (:end . 160)\n  (:start . 151) (:id . 67))\n ((:tag . "NN") (:stem . "rag2") (:form . 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5102007@unknown@formal@none@1@S@In any case, the origin of the V(D)J recombination system in jawless vertebrates appears to be a culmination of earlier evolutionary processes rather than an isolated event associated with insertion of a single transposon.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 23)\n  (:start . 17) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 36) (:start . 31)\n  (:id . 50))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 50) (:start . 37) (:id . 51))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 57)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "jawless") (:form . "jawless") (:end . 68)\n  (:start . 61) (:id . 54))\n ((:tag . "NNS") (:stem . "vertebrate") (:form . "vertebrates") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 88)\n  (:start . 81) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 59))\n ((:tag . "NN") (:stem . "culmination") (:form . "culmination") (:end . 108)\n  (:start . 97) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 132)\n  (:start . 120) (:id . 63))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 149)\n  (:start . 143) (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 154) (:start . 150)\n  (:id . 66))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 166)\n  (:start . 158) (:id . 68))\n ((:tag . "NN") (:stem . "event") (:form . "event") (:end . 172)\n  (:start . 167) (:id . 69))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 183)\n  (:start . 173) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 188) (:start . 184)\n  (:id . 71))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 198)\n  (:start . 189) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 201) (:start . 199)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 203) (:start . 202)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 210)\n  (:start . 204) (:id . 75))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 221)\n  (:start . 211) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x6.268.2) (:span 81 88)))\n (:ncues ((:id . :x6.268.1) (:span 143 154)))\n (:hscopes ((:id . :x6.268.2) (:span 13 221)))\n (:nscopes ((:id . :x6.268.1) (:span 143 221)))\n (:identifiers (:sid . :s6.268) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102008@unknown@formal@none@1@S@If so, detailed studies of individual components, including active Transib transposons and invertebrate proteins homologous to RAG1 elements can bring new breakthroughs in our understanding of evolutionary and mechanistic aspects of V(D)J recombination.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 44))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 15)\n  (:start . 7) (:id . 45))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "individual") (:form . "individual") (:end . 37)\n  (:start . 27) (:id . 48))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 59)\n  (:start . 50) (:id . 51))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 74)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "invertebrate") (:form . "invertebrate") (:end . 103)\n  (:start . 91) (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 112)\n  (:start . 104) (:id . 57))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 123)\n  (:start . 113) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 59))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 131) (:start . 127)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 140)\n  (:start . 132) (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 144) (:start . 141)\n  (:id . 62))\n ((:tag . "VB") (:stem . "bring") (:form . "bring") (:end . 150)\n  (:start . 145) (:id . 63))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 154) (:start . 151)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "breakthrough") (:form . "breakthroughs")\n  (:end . 168) (:start . 155) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 66))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 175) (:start . 172)\n  (:id . 67))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 189) (:start . 176) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "evolutionary") (:form . "evolutionary") (:end . 205)\n  (:start . 193) (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mechanistic") (:form . "mechanistic") (:end . 221)\n  (:start . 210) (:id . 72))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 229)\n  (:start . 222) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 232) (:start . 230)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 238)\n  (:start . 233) (:id . 75))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 252) (:start . 239) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x6.269.1) (:span 141 144)))\n (:hscopes ((:id . :x6.269.1) (:span 141 252)))\n (:identifiers (:sid . :s6.269) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102010@unknown@formal@none@1@S@For instance, on the basis of the TPase comparison to RAG1 (see Figures S1 and S3), we were able to identify correct positions of the last two aa residues in the DDE catalytic triad (see Figure 2 in [17]), missed in our previous study due to insufficient data.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 26) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . 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"(") (:end . 183) (:start . 182)\n  (:id . 80))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 186) (:start . 183)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 193)\n  (:start . 187) (:id . 82))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 195) (:start . 194)\n  (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 198) (:start . 196)\n  (:id . 84))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 200) (:start . 199)\n  (:id . 85))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 202) (:start . 200)\n  (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 203) (:start . 202)\n  (:id . 87))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 89))\n ((:tag . "VBN") (:stem . "miss") (:form . "missed") (:end . 212)\n  (:start . 206) (:id . 90))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 215) (:start . 213)\n  (:id . 91))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 219) (:start . 216)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 228)\n  (:start . 220) (:id . 93))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 234)\n  (:start . 229) (:id . 94))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 238) (:start . 235)\n  (:id . 95))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 241) (:start . 239)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "insufficient") (:form . "insufficient") (:end . 254)\n  (:start . 242) (:id . 97))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 259)\n  (:start . 255) (:id . 98))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 260) (:start . 259)\n  (:id . 99)))@@@1@58@((:identifiers (:sid . :s6.271) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102011@unknown@formal@none@1@S@Interestingly, only two cysteines of the zinc finger B (ZFB) C2H2 motif in RAG1 (residues 695–761) involved in its binding to RAG2 [30,31] are perfectly conserved in the Transib TPases (motif 7; see Figures 3 and Figure S3).@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cysteine") (:form . "cysteines") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ZFB") (:form . "ZFB") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "c2h2") (:form . "C2H2") (:end . 65) (:start . 61)\n  (:id . 55))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 57))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 79) (:start . 75)\n  (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 89)\n  (:start . 81) (:id . 60))\n ((:tag . "CD") (:stem . "695–761") (:form . "695–761") (:end . 97)\n  (:start . 90) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 107)\n  (:start . 99) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rag2") (:form . "RAG2") (:end . 130) (:start . 126)\n  (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 132) (:start . 131)\n  (:id . 69))\n ((:tag . "CD") (:stem . "30,31") (:form . "30,31") (:end . 137)\n  (:start . 132) (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 138) (:start . 137)\n  (:id . 71))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 142) (:start . 139)\n  (:id . 72))\n ((:tag . "RB") (:stem . "perfectly") (:form . "perfectly") (:end . 152)\n  (:start . 143) (:id . 73))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 162)\n  (:start . 153) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 169) (:start . 166)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 177)\n  (:start . 170) (:id . 77))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 184)\n  (:start . 178) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 79))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 191)\n  (:start . 186) (:id . 80))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 193) (:start . 192)\n  (:id . 81))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 194) (:start . 193)\n  (:id . 82))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 198) (:start . 195)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 206)\n  (:start . 199) (:id . 84))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 208) (:start . 207)\n  (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 212) (:start . 209)\n  (:id . 86))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 219)\n  (:start . 213) (:id . 87))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 222) (:start . 220)\n  (:id . 88))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 223) (:start . 222)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s6.272) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102012@unknown@formal@none@1@S@The remaining portion of the ZFB motif was probably lost in TPases of insect Transib transposons, which do not encode RAG2-like proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "portion") (:form . "portion") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "ZFB") (:form . "ZFB") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "VBN") (:stem . "lose") (:form . "lost") (:end . 56) (:start . 52)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 66) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "insect") (:form . "insect") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 96)\n  (:start . 85) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 103)\n  (:start . 98) (:id . 59))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 110) (:start . 107)\n  (:id . 61))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . "JJ") (:stem . "rag2-like") (:form . "RAG2-like") (:end . 127)\n  (:start . 118) (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 136)\n  (:start . 128) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x6.273.2) (:span 43 51)))\n (:ncues ((:id . :x6.273.1) (:span 107 110)))\n (:hscopes ((:id . :x6.273.2) (:span 0 136)))\n (:nscopes ((:id . :x6.273.1) (:span 107 136)))\n (:identifiers (:sid . :s6.273) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102013@unknown@formal@none@1@S@Notably, two ZFB cysteines are part of the conserved SxxCxxC motif, and mutations of the serine from the same motif cause severe defects in RAG1 transpositions in vitro [32].@(((:tag . "RB") (:stem . "notably") (:form . "Notably") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ZFB") (:form . "ZFB") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cysteine") (:form . "cysteines") (:end . 26)\n  (:start . 17) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "NNP") (:stem . "SxxCxxC") (:form . "SxxCxxC") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 81)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 95)\n  (:start . 89) (:id . 59))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "VBP") (:stem . "cause") (:form . "cause") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 128)\n  (:start . 122) (:id . 65))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 136)\n  (:start . 129) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 144) (:start . 140)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 159) (:start . 145) (:id . 69))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 168)\n  (:start . 163) (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 170) (:start . 169)\n  (:id . 72))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 172) (:start . 170)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 173) (:start . 172)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s6.274) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102014@unknown@formal@none@1@S@Therefore, the presence of serine in this motif is expected to be crucial to Transib transpositions.@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "serine") (:form . "serine") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 41) (:start . 37)\n  (:id . 49))\n ((:tag . "NN") (:stem . "motif") (:form . "motif") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 59)\n  (:start . 51) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 73)\n  (:start . 66) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "VB") (:stem . "transib") (:form . "Transib") (:end . 84)\n  (:start . 77) (:id . 57))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 99) (:start . 85) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x6.275.1) (:span 51 59)))\n (:hscopes ((:id . :x6.275.1) (:span 11 99)))\n (:identifiers (:sid . :s6.275) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102015@unknown@formal@none@1@S@After submission of our manuscript, additional biochemical evidence favoring evolution of V(D)J recombination from transposable elements was reported [25].@(((:tag . "IN") (:stem . "after") (:form . "After") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "submission") (:form . "submission") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "manuscript") (:form . "manuscript") (:end . 34)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "VBG") (:stem . "favor") (:form . "favoring") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 86)\n  (:start . 77) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 109) (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "transposable") (:form . "transposable") (:end . 127)\n  (:start . 115) (:id . 57))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 136)\n  (:start . 128) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 140) (:start . 137)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 149)\n  (:start . 141) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 151) (:start . 150)\n  (:id . 61))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 154) (:start . 153)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x6.276.1) (:span 68 76)))\n (:hscopes ((:id . :x6.276.1) (:span 68 136)))\n (:identifiers (:sid . :s6.276) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102016@unknown@formal@none@1@S@Analogously to V(D)J recombination, transposition of the fly Hermes transposon, which belongs to the hAT superfamily, is also characterized by a double-strand break via hairpin formation on flanking DNA and 3? OH joining to the target DNA [25].@(((:tag . "RB") (:stem . "analogously") (:form . "Analogously") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 34) (:start . 21) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 46))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 49) (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "fly") (:form . "fly") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Hermes") (:form . "Hermes") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 78)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "belong") (:form . "belongs") (:end . 93)\n  (:start . 86) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "superfamily") (:form . "superfamily") (:end . 116)\n  (:start . 105) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 139) (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "double-strand") (:form . "double-strand")\n  (:end . 158) (:start . 145) (:id . 66))\n ((:tag . "NN") (:stem . "break") (:form . "break") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 168) (:start . 165)\n  (:id . 68))\n ((:tag . "NN") (:stem . "hairpin") (:form . "hairpin") (:end . 176)\n  (:start . 169) (:id . 69))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 186)\n  (:start . 177) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 189) (:start . 187)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 198)\n  (:start . 190) (:id . 72))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 202) (:start . 199)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 206) (:start . 203)\n  (:id . 74))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 208) (:start . 207)\n  (:id . 75))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 209) (:start . 208)\n  (:id . 76))\n ((:tag . "NN") (:stem . "oh") (:form . "OH") (:end . 212) (:start . 210)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "join") (:form . "joining") (:end . 220)\n  (:start . 213) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 223) (:start . 221)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 80))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 234)\n  (:start . 228) (:id . 81))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 238) (:start . 235)\n  (:id . 82))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 240) (:start . 239)\n  (:id . 83))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 242) (:start . 240)\n  (:id . 84))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 243) (:start . 242)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s6.277) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102017@unknown@formal@none@1@S@However, although the observed biochemical relationship between the hAT TPase and V(D)J recombination is a step forward in our understanding of transposition reaction, several arguments strongly suggest that V(D)J machinery evolved from a Transib rather than from hAT transposon.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 42)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "relationship") (:form . "relationship") (:end . 55)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 63)\n  (:start . 56) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 77) (:start . 72)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 101) (:start . 88) (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 104) (:start . 102)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "RB") (:stem . "forward") (:form . "forward") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 140) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 157) (:start . 144) (:id . 64))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 166)\n  (:start . 158) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 175)\n  (:start . 168) (:id . 67))\n ((:tag . "NNS") (:stem . "argument") (:form . "arguments") (:end . 185)\n  (:start . 176) (:id . 68))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 194)\n  (:start . 186) (:id . 69))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 202)\n  (:start . 195) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 207) (:start . 203)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 213)\n  (:start . 208) (:id . 72))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 223)\n  (:start . 214) (:id . 73))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 231)\n  (:start . 224) (:id . 74))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 236) (:start . 232)\n  (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 238) (:start . 237)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 246)\n  (:start . 239) (:id . 77))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 253)\n  (:start . 247) (:id . 78))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 258) (:start . 254)\n  (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 263) (:start . 259)\n  (:id . 80))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 267) (:start . 264)\n  (:id . 81))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 278)\n  (:start . 268) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x6.278.2) (:span 195 202)))\n (:ncues ((:id . :x6.278.1) (:span 247 258)))\n (:hscopes ((:id . :x6.278.2) (:span 195 278)))\n (:nscopes ((:id . :x6.278.1) (:span 247 278)))\n (:identifiers (:sid . :s6.278) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102018@unknown@formal@none@1@S@First, as we mentioned previously, there is no significant sequence identity between hAT TPases and RAG1, even if one employs a PSI-BLAST search with most relaxed parameters (i.e., E < 10, no filters, no composition-based statistics).@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "mention") (:form . "mentioned") (:end . 22)\n  (:start . 13) (:id . 46))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 33)\n  (:start . 23) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 58)\n  (:start . 47) (:id . 52))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 95) (:start . 89)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 104) (:start . 100)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "employ") (:form . "employs") (:end . 125)\n  (:start . 118) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 137)\n  (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 144)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 149) (:start . 145)\n  (:id . 68))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 154) (:start . 150)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "relax") (:form . "relaxed") (:end . 162)\n  (:start . 155) (:id . 70))\n ((:tag . "NNS") (:stem . "parameter") (:form . "parameters") (:end . 173)\n  (:start . 163) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 72))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 179) (:start . 175)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 182) (:start . 181)\n  (:id . 75))\n ((:tag . "SYM") (:stem . "<") (:form . "<") (:end . 184) (:start . 183)\n  (:id . 76))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 187) (:start . 185)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 188) (:start . 187)\n  (:id . 78))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 191) (:start . 189)\n  (:id . 79))\n ((:tag . "NNS") (:stem . "filter") (:form . "filters") (:end . 199)\n  (:start . 192) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 200) (:start . 199)\n  (:id . 81))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 203) (:start . 201)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "composition-based") (:form . "composition-based")\n  (:end . 221) (:start . 204) (:id . 83))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 232)\n  (:start . 222) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 233) (:start . 232)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x6.279.1) (:span 201 203))\n  ((:id . :x6.279.2) (:span 189 191)))\n (:nscopes ((:id . :x6.279.1) (:span 201 232))\n  ((:id . :x6.279.2) (:span 189 199)))\n (:identifiers (:sid . :s6.279) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102020@unknown@formal@none@1@S@Third, unlike in the case of Transib transposons, TIRs of hAT transposons are different from RSS both in terms of DNA sequence similarities and their conservation patterns (Figure S7).@(((:tag . "RB") (:stem . "third") (:form . "Third") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 48)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 54) (:start . 50)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 73)\n  (:start . 62) (:id . 55))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 87)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 110)\n  (:start . 105) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 117) (:start . 114)\n  (:id . 64))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 126)\n  (:start . 118) (:id . 65))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 139)\n  (:start . 127) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 162)\n  (:start . 150) (:id . 69))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 171)\n  (:start . 163) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 179)\n  (:start . 173) (:id . 72))\n ((:tag . "NNP") (:stem . "S7") (:form . "S7") (:end . 182) (:start . 180)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 183) (:start . 182)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 184) (:start . 183)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s6.281) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102021@unknown@formal@none@1@S@Fourth, hAT- and RAG1/2-mediated transpositions differ dramatically in terms of the GC content of their target sites: Unlike Transib transposons and RAG1 transpositions occurring in GC-rich DNA, hAT transposons tend to be integrated into AT-rich regions (Table S2).@(((:tag . "NN") (:stem . "fourth") (:form . "Fourth") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NN") (:stem . "hat-") (:form . "hAT-") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "rag1/2-mediated") (:form . "RAG1/2-mediated")\n  (:end . 32) (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "VBP") (:stem . "differ") (:form . "differ") (:end . 54)\n  (:start . 48) (:id . 48))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 67)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "term") (:form . "terms") (:end . 76) (:start . 71)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "NN") (:stem . "content") (:form . "content") (:end . 94)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 103)\n  (:start . 98) (:id . 57))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 116)\n  (:start . 111) (:id . 59))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 117) (:start . 116)\n  (:id . 60))\n ((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 124)\n  (:start . 118) (:id . 61))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 132)\n  (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 144)\n  (:start . 133) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 148) (:start . 145)\n  (:id . 64))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 153) (:start . 149)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 168) (:start . 154) (:id . 66))\n ((:tag . "VBG") (:stem . "occur") (:form . "occurring") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "gc-rich") (:form . "GC-rich") (:end . 189)\n  (:start . 182) (:id . 69))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 193) (:start . 190)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 194) (:start . 193)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 198) (:start . 195)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 210)\n  (:start . 199) (:id . 73))\n ((:tag . "VBP") (:stem . "tend") (:form . "tend") (:end . 215) (:start . 211)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 218) (:start . 216)\n  (:id . 75))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 221) (:start . 219)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 232)\n  (:start . 222) (:id . 77))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 237) (:start . 233)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "at-rich") (:form . "AT-rich") (:end . 245)\n  (:start . 238) (:id . 79))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 253)\n  (:start . 246) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 255) (:start . 254)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 260)\n  (:start . 255) (:id . 82))\n ((:tag . "NNP") (:stem . "S2") (:form . "S2") (:end . 263) (:start . 261)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 264) (:start . 263)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s6.282) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102022@unknown@formal@none@1@S@All four arguments strongly favor evolution of V(D)J machinery from a Transib transposon.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "argument") (:form . "arguments") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "favor") (:form . "favor") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "evolution") (:form . "evolution") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 62)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 88)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x6.283.1) (:span 28 33)))\n (:hscopes ((:id . :x6.283.1) (:span 28 88)))\n (:identifiers (:sid . :s6.283) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102023@unknown@formal@none@1@S@Most likely, the Transib transpositions are also characterized by hairpin intermediates formed by the ends of the donor DNA double-strand breaks, as observed during V(D)J recombination and hAT transposition.@(((:tag . "RBS") (:stem . "most") (:form . "Most") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "NNS") (:stem . "transposition") (:form . "transpositions")\n  (:end . 39) (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hairpin") (:form . "hairpin") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "intermediate") (:form . "intermediates")\n  (:end . 87) (:start . 74) (:id . 53))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 94) (:start . 88)\n  (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 101) (:start . 98)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "end") (:form . "ends") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "NN") (:stem . "donor") (:form . "donor") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "double-strand") (:form . "double-strand")\n  (:end . 137) (:start . 124) (:id . 62))\n ((:tag . "NNS") (:stem . "break") (:form . "breaks") (:end . 144)\n  (:start . 138) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 145) (:start . 144)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 164)\n  (:start . 158) (:id . 67))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 184) (:start . 171) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 188) (:start . 185)\n  (:id . 70))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 192) (:start . 189)\n  (:id . 71))\n ((:tag . "NN") (:stem . "transposition") (:form . "transposition")\n  (:end . 206) (:start . 193) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x6.284.1) (:span 5 11)))\n (:hscopes ((:id . :x6.284.1) (:span 5 144)))\n (:identifiers (:sid . :s6.284) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102024@unknown@formal@none@1@S@Materials and Methods@(((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 21)\n  (:start . 14) (:id . 44)))@@@1@3@((:identifiers (:sid . :s6.285) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102025@unknown@formal@none@1@S@DNA and protein sequences.@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 26) (:start . 25)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s6.286) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102026@unknown@formal@none@1@S@Assembled D. pseudoobscura sequences were downloaded from the Human Genome Sequencing Center at Baylor College of Medicine through the Web site at http://hgsc.bcm.tmc.edu/projects/drosophila/ on 2 March 2004.@(((:tag . "NNP") (:stem . "Assembled") (:form . "Assembled") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 26) (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 67) (:start . 62)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Genome") (:form . "Genome") (:end . 74)\n  (:start . 68) (:id . 51))\n ((:tag . "NNP") (:stem . "Sequencing") (:form . "Sequencing") (:end . 85)\n  (:start . 75) (:id . 52))\n ((:tag . "NNP") (:stem . "Center") (:form . "Center") (:end . 92)\n  (:start . 86) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Baylor") (:form . "Baylor") (:end . 102)\n  (:start . 96) (:id . 55))\n ((:tag . "NNP") (:stem . "College") (:form . "College") (:end . 110)\n  (:start . 103) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Medicine") (:form . "Medicine") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 130)\n  (:start . 123) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Web") (:form . "Web") (:end . 138) (:start . 135)\n  (:id . 61))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 143) (:start . 139)\n  (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . "NN") (:stem . "http://hgsc.bcm.tmc.edu/projects/drosophila/")\n  (:form . "http://hgsc.bcm.tmc.edu/projects/drosophila/") (:end . 191)\n  (:start . 147) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 194) (:start . 192)\n  (:id . 65))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 196) (:start . 195)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "March") (:form . "March") (:end . 202)\n  (:start . 197) (:id . 67))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 207) (:start . 203)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.287) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102027@unknown@formal@none@1@S@Preliminary A. aegypti sequence data were obtained from The Institute for Genomic Research through the Web site at http://www.tigr.org on 4 March 2004.@(((:tag . "JJ") (:stem . "preliminary") (:form . "Preliminary") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "a.") (:form . "A.") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "aegypti") (:form . "aegypti") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 31)\n  (:start . 23) (:id . 45))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 50)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Institute") (:form . "Institute") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Genomic") (:form . "Genomic") (:end . 81)\n  (:start . 74) (:id . 53))\n ((:tag . "NNP") (:stem . "Research") (:form . "Research") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 98)\n  (:start . 91) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Web") (:form . "Web") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 114) (:start . 112)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "http://www.tigr.org")\n  (:form . "http://www.tigr.org") (:end . 134) (:start . 115) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 137) (:start . 135)\n  (:id . 61))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 139) (:start . 138)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "March") (:form . "March") (:end . 145)\n  (:start . 140) (:id . 63))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s6.288) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102028@unknown@formal@none@1@S@Assembled D. melanogaster sequences were downloaded from the Berkeley Drosophila Genome Project at http://www.fruitfly.org/sequence/download.html on 17 February 2004.@(((:tag . "NNP") (:stem . "Assembled") (:form . "Assembled") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 25)\n  (:start . 13) (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 35)\n  (:start . 26) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 51)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 56) (:start . 52)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Berkeley") (:form . "Berkeley") (:end . 69)\n  (:start . 61) (:id . 50))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "NNP") (:stem . "Genome") (:form . "Genome") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "NNP") (:stem . "Project") (:form . "Project") (:end . 95)\n  (:start . 88) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 98) (:start . 96)\n  (:id . 54))\n ((:tag . "NN") (:stem . "http://www.fruitfly.org/sequence/download.html")\n  (:form . "http://www.fruitfly.org/sequence/download.html") (:end . 145)\n  (:start . 99) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 56))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 151) (:start . 149)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "February") (:form . "February") (:end . 160)\n  (:start . 152) (:id . 58))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 165) (:start . 161)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.289) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102030@unknown@formal@none@1@S@In addition to the assembled contigs, Baylor College of Medicine, Human Genome Sequencing Center (http://www.hgsc.bcm.tmc.edu) produced an approximately 8-Gb set of short unassembled WGS sequences, called “traces”, which cover nearly the entire sea urchin genome.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "contig") (:form . "contigs") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Baylor") (:form . "Baylor") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "College") (:form . "College") (:end . 52)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Medicine") (:form . "Medicine") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Human") (:form . "Human") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Genome") (:form . "Genome") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NNP") (:stem . "Sequencing") (:form . "Sequencing") (:end . 89)\n  (:start . 79) (:id . 56))\n ((:tag . "NNP") (:stem . "Center") (:form . "Center") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "http://www.hgsc.bcm.tmc.edu")\n  (:form . "http://www.hgsc.bcm.tmc.edu") (:end . 125) (:start . 98)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 135)\n  (:start . 127) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 138) (:start . 136)\n  (:id . 62))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 152) (:start . 139) (:id . 63))\n ((:tag . "JJ") (:stem . "8-gb") (:form . "8-Gb") (:end . 157) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 161) (:start . 158)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 164) (:start . 162)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 170)\n  (:start . 165) (:id . 67))\n ((:tag . "JJ") (:stem . "unassembled") (:form . "unassembled") (:end . 182)\n  (:start . 171) (:id . 68))\n ((:tag . "NN") (:stem . "wgs") (:form . "WGS") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 196)\n  (:start . 187) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 197) (:start . 196)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 204)\n  (:start . 198) (:id . 72))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 206) (:start . 205)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "traces") (:form . "traces") (:end . 212)\n  (:start . 206) (:id . 74))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 213) (:start . 212)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 76))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 220)\n  (:start . 215) (:id . 77))\n ((:tag . "VBP") (:stem . "cover") (:form . "cover") (:end . 226)\n  (:start . 221) (:id . 78))\n ((:tag . "RB") (:stem . "nearly") (:form . "nearly") (:end . 233)\n  (:start . 227) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 237) (:start . 234)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 244)\n  (:start . 238) (:id . 81))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 248) (:start . 245)\n  (:id . 82))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 255)\n  (:start . 249) (:id . 83))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 262)\n  (:start . 256) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s6.291) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102031@unknown@formal@none@1@S@We downloaded these sequences from the GenBank Trace Archive at the National Center for Biotechnology Information (NCBI; ftp://ftp.ncbi.nih.gov/pub/TraceDB/strongylocentrotus_purpuratus/) on 17 November 2004.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "downloade") (:form . "downloaded") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Archive") (:form . "Archive") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "National") (:form . "National") (:end . 76)\n  (:start . 68) (:id . 53))\n ((:tag . "NNP") (:stem . "Center") (:form . "Center") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Biotechnology") (:form . "Biotechnology")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "NNP") (:stem . "Information") (:form . "Information") (:end . 113)\n  (:start . 102) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 115) (:start . 114)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "NCBI") (:form . "NCBI") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 120) (:start . 119)\n  (:id . 60))\n ((:tag . "CD")\n  (:stem\n   . "ftp://ftp.ncbi.nih.gov/pub/TraceDB/strongylocentrotus_purpuratus/")\n  (:form\n   . "ftp://ftp.ncbi.nih.gov/pub/TraceDB/strongylocentrotus_purpuratus/")\n  (:end . 186) (:start . 121) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 190) (:start . 188)\n  (:id . 63))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 193) (:start . 191)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "November") (:form . "November") (:end . 202)\n  (:start . 194) (:id . 65))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 207) (:start . 203)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.292) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102032@unknown@formal@none@1@S@Also, we downloaded an approximately 5-Gb set of unassembled traces that cover almost completely the 600-Mb genome of Florida lancelet (ftp://ftp.ncbi.nih.gov/pub/TraceDB/branchiostoma_floridae/; 3 December 2004).@(((:tag . "RB") (:stem . "also") (:form . "Also") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 8) (:start . 6)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "downloade") (:form . "downloaded") (:end . 19)\n  (:start . 9) (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 36) (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "5-gb") (:form . "5-Gb") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "unassembled") (:form . "unassembled") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "trace") (:form . "traces") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "cover") (:form . "cover") (:end . 78) (:start . 73)\n  (:id . 54))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 85)\n  (:start . 79) (:id . 55))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "600-mb") (:form . "600-Mb") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 114)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Florida") (:form . "Florida") (:end . 125)\n  (:start . 118) (:id . 61))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 134)\n  (:start . 126) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 63))\n ((:tag . "NNP")\n  (:stem . "ftp://ftp.ncbi.nih.gov/pub/TraceDB/branchiostoma_floridae/")\n  (:form . "ftp://ftp.ncbi.nih.gov/pub/TraceDB/branchiostoma_floridae/")\n  (:end . 194) (:start . 136) (:id . 64))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 195) (:start . 194)\n  (:id . 65))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 197) (:start . 196)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "December") (:form . "December") (:end . 206)\n  (:start . 198) (:id . 67))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 211) (:start . 207)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s6.293) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102033@unknown@formal@none@1@S@These sequences were produced and deposited in the GenBank Trace Archive by Department of Energy Joint Genomic Institute (http://www.jgi.doe.gov/).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 15)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 29)\n  (:start . 21) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "deposit") (:form . "deposited") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Archive") (:form . "Archive") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Department") (:form . "Department") (:end . 86)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Energy") (:form . "Energy") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NNP") (:stem . "Joint") (:form . "Joint") (:end . 102)\n  (:start . 97) (:id . 57))\n ((:tag . "NNP") (:stem . "Genomic") (:form . "Genomic") (:end . 110)\n  (:start . 103) (:id . 58))\n ((:tag . "NNP") (:stem . "Institute") (:form . "Institute") (:end . 120)\n  (:start . 111) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "http://www.jgi.doe.gov/")\n  (:form . "http://www.jgi.doe.gov/") (:end . 145) (:start . 122) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 146) (:start . 145)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.294) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102034@unknown@formal@none@1@S@All other DNA and protein sequences were accessed from GenBank (NCBI) through the server at http://www.ncbi.nih.gov/Genbank/ and from Ensembl (EMBL-EBI and Sanger Institute) via the server at http://www.ensembl.org.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "access") (:form . "accessed") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "NCBI") (:form . "NCBI") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 69) (:start . 68)\n  (:id . 54))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 77)\n  (:start . 70) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "server") (:form . "server") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "http://www.ncbi.nih.gov/Genbank/")\n  (:form . "http://www.ncbi.nih.gov/Genbank/") (:end . 124) (:start . 92)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 133) (:start . 129)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Ensembl") (:form . "Ensembl") (:end . 141)\n  (:start . 134) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 143) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "EMBL-EBI") (:form . "EMBL-EBI") (:end . 151)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Sanger") (:form . "Sanger") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . "NNP") (:stem . "Institute") (:form . "Institute") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 177) (:start . 174)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "server") (:form . "server") (:end . 188)\n  (:start . 182) (:id . 71))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 191) (:start . 189)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "http://www.ensembl.org")\n  (:form . "http://www.ensembl.org") (:end . 214) (:start . 192) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.295) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102035@unknown@formal@none@1@S@Sequences of the Transib1 through Transib4 and Transib1_AG through Transib3_AG transposons [17] were obtained from the D. melanogaster (drorep.ref) and A. gambiae (angrep.ref) sections of Repbase Update [39] at Genetic Information Research Institute (http://www.girinst.org).@(((:tag . "NNS") (:stem . "sequence") (:form . "Sequences") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transib1") (:form . "Transib1") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "NNP") (:stem . "Transib4") (:form . "Transib4") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Transib1_AG") (:form . "Transib1_AG") (:end . 58)\n  (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "NNP") (:stem . "Transib3_AG") (:form . "Transib3_AG") (:end . 78)\n  (:start . 67) (:id . 51))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 90)\n  (:start . 79) (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 92) (:start . 91)\n  (:id . 53))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 94) (:start . 92)\n  (:id . 54))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 109)\n  (:start . 101) (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 134)\n  (:start . 122) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 136) (:start . 135)\n  (:id . 62))\n ((:tag . "NN") (:stem . "drorep.ref") (:form . "drorep.ref") (:end . 146)\n  (:start . 136) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "A.") (:form . "A.") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gambiae") (:form . "gambiae") (:end . 162)\n  (:start . 155) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "angrep.ref") (:form . "angrep.ref") (:end . 174)\n  (:start . 164) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 175) (:start . 174)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 184)\n  (:start . 176) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Repbase") (:form . "Repbase") (:end . 195)\n  (:start . 188) (:id . 73))\n ((:tag . "NNP") (:stem . "Update") (:form . "Update") (:end . 202)\n  (:start . 196) (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 204) (:start . 203)\n  (:id . 75))\n ((:tag . "CD") (:stem . "39") (:form . "39") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 207) (:start . 206)\n  (:id . 77))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 210) (:start . 208)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "genetic") (:form . "Genetic") (:end . 218)\n  (:start . 211) (:id . 79))\n ((:tag . "NNP") (:stem . "Information") (:form . "Information") (:end . 230)\n  (:start . 219) (:id . 80))\n ((:tag . "NNP") (:stem . "Research") (:form . "Research") (:end . 239)\n  (:start . 231) (:id . 81))\n ((:tag . "NNP") (:stem . "Institute") (:form . "Institute") (:end . 249)\n  (:start . 240) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 251) (:start . 250)\n  (:id . 83))\n ((:tag . "NN") (:stem . "http://www.girinst.org")\n  (:form . "http://www.girinst.org") (:end . 273) (:start . 251) (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 274) (:start . 273)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 275) (:start . 274)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s6.296) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102036@unknown@formal@none@1@S@Sequence analysis.@(((:tag . "NN") (:stem . "sequence") (:form . "Sequence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 18) (:start . 17)\n  (:id . 44)))@@@1@3@((:identifiers (:sid . :s6.297) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102037@unknown@formal@none@1@S@Computer-assisted identification and reconstruction of the Transib transposons was done as described previously [17,40–42].@(((:tag . "JJ") (:stem . "computer-assisted") (:form . "Computer-assisted")\n  (:end . 17) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 32) (:start . 18) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reconstruction") (:form . "reconstruction")\n  (:end . 51) (:start . 37) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 66)\n  (:start . 59) (:id . 48))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 78)\n  (:start . 67) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 87) (:start . 83)\n  (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 100)\n  (:start . 91) (:id . 53))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 111)\n  (:start . 101) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 113) (:start . 112)\n  (:id . 55))\n ((:tag . "CD") (:stem . "17,40–42") (:form . "17,40–42") (:end . 121)\n  (:start . 113) (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 122) (:start . 121)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.298) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102038@unknown@formal@none@1@S@DNA sequence analysis including local sequence alignments, multiple alignments, and reconstruction of the Transib consensus sequences was done using software developed at Genetic Information Research Institute (available upon request) and WU-BLASTN 2.0 (http://blast.wustl.edu).@(((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "local") (:form . "local") (:end . 37) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 57)\n  (:start . 47) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 78)\n  (:start . 68) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 79) (:start . 78)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 53))\n ((:tag . "NN") (:stem . "reconstruction") (:form . "reconstruction")\n  (:end . 98) (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 113)\n  (:start . 106) (:id . 57))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 123)\n  (:start . 114) (:id . 58))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 133)\n  (:start . 124) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 137) (:start . 134)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 142) (:start . 138)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 148) (:start . 143)\n  (:id . 62))\n ((:tag . "NN") (:stem . "software") (:form . "software") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 167)\n  (:start . 158) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 170) (:start . 168)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Genetic") (:form . "Genetic") (:end . 178)\n  (:start . 171) (:id . 66))\n ((:tag . "NNP") (:stem . "Information") (:form . "Information") (:end . 190)\n  (:start . 179) (:id . 67))\n ((:tag . "NNP") (:stem . "Research") (:form . "Research") (:end . 199)\n  (:start . 191) (:id . 68))\n ((:tag . "NNP") (:stem . "Institute") (:form . "Institute") (:end . 209)\n  (:start . 200) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 211) (:start . 210)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 220)\n  (:start . 211) (:id . 71))\n ((:tag . "IN") (:stem . "upon") (:form . "upon") (:end . 225) (:start . 221)\n  (:id . 72))\n ((:tag . "NN") (:stem . "request") (:form . "request") (:end . 233)\n  (:start . 226) (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 234) (:start . 233)\n  (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 238) (:start . 235)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "WU-BLASTN") (:form . "WU-BLASTN") (:end . 248)\n  (:start . 239) (:id . 76))\n ((:tag . "CD") (:stem . "2.0") (:form . "2.0") (:end . 252) (:start . 249)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 254) (:start . 253)\n  (:id . 78))\n ((:tag . "NN") (:stem . "http://blast.wustl.edu")\n  (:form . "http://blast.wustl.edu") (:end . 276) (:start . 254) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 277) (:start . 276)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 278) (:start . 277)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s6.299) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102040@unknown@formal@none@1@S@(We included in the analysis incomplete relics of the Transib2–5_AA TPases represented by single DNA copies.)@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 3) (:start . 1)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "include") (:form . "included") (:end . 12)\n  (:start . 4) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 28)\n  (:start . 20) (:id . 47))\n ((:tag . "JJ") (:stem . "incomplete") (:form . "incomplete") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "relic") (:form . "relics") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Transib2–5_AA") (:form . "Transib2–5_AA")\n  (:end . 67) (:start . 54) (:id . 52))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 74) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 86)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 89) (:start . 87)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 96)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 107)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.301) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102041@unknown@formal@none@1@S@Prediction of putative exons and introns encoded by the Transib consensus sequences was done with FGENESH [33] (at http://www.softberry.com).@(((:tag . "NN") (:stem . "prediction") (:form . "Prediction") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "intron") (:form . "introns") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 73)\n  (:start . 64) (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 97) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "FGENESH") (:form . "FGENESH") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "http://www.softberry.com")\n  (:form . "http://www.softberry.com") (:end . 139) (:start . 115) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x6.302.1) (:span 14 22)))\n (:hscopes ((:id . :x6.302.1) (:span 14 83)))\n (:identifiers (:sid . :s6.302) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102042@unknown@formal@none@1@S@Multiple alignments of distantly related RAG1 and Transib TPase protein sequences were created by T-Coffee [40].@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "alignment") (:form . "alignments") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "RB") (:stem . "distantly") (:form . "distantly") (:end . 32)\n  (:start . 23) (:id . 45))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 40)\n  (:start . 33) (:id . 46))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 45) (:start . 41)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 63) (:start . 58)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 71)\n  (:start . 64) (:id . 51))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 81)\n  (:start . 72) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 86) (:start . 82)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "create") (:form . "created") (:end . 94)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 97) (:start . 95)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "T-Coffee") (:form . "T-Coffee") (:end . 106)\n  (:start . 98) (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 110) (:start . 108)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.303) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102043@unknown@formal@none@1@S@Shading and minor manual refinements of the aligned sequences were done using Genedoc [43].@(((:tag . "VBG") (:stem . "shade") (:form . "Shading") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 11) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "minor") (:form . "minor") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "manual") (:form . "manual") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "refinement") (:form . "refinements") (:end . 36)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "align") (:form . "aligned") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 71) (:start . 67)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Genedoc") (:form . "Genedoc") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "CD") (:stem . "43") (:form . "43") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 90) (:start . 89)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.304) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102044@unknown@formal@none@1@S@Phylogenetic trees were produced by using MEGA3 [44].@(((:tag . "JJ") (:stem . "phylogenetic") (:form . "Phylogenetic") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "tree") (:form . "trees") (:end . 18) (:start . 13)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mega3") (:form . "MEGA3") (:end . 47) (:start . 42)\n  (:id . 48))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "44") (:form . "44") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 53) (:start . 52)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.305) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102045@unknown@formal@none@1@S@Some of the sea urchin sequences encoding the RAG1 N-terminal domain were assembled from traces based on the Baylor BAC-Fisher server at http://www.hgsc.bcm.tmc.edu/BAC-Fisher/ (the results of assembly were verified manually).@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 32)\n  (:start . 23) (:id . 47))\n ((:tag . "VBG") (:stem . "encode") (:form . "encoding") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "n-terminal") (:form . "N-terminal") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "trace") (:form . "traces") (:end . 95)\n  (:start . 89) (:id . 56))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Baylor") (:form . "Baylor") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "NNP") (:stem . "BAC-Fisher") (:form . "BAC-Fisher") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "server") (:form . "server") (:end . 133)\n  (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "http://www.hgsc.bcm.tmc.edu/BAC-Fisher/")\n  (:form . "http://www.hgsc.bcm.tmc.edu/BAC-Fisher/") (:end . 176)\n  (:start . 137) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 189)\n  (:start . 182) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 68))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 201)\n  (:start . 193) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 206) (:start . 202)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "verify") (:form . "verified") (:end . 215)\n  (:start . 207) (:id . 71))\n ((:tag . "RB") (:stem . "manually") (:form . "manually") (:end . 224)\n  (:start . 216) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 225) (:start . 224)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.306) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102046@unknown@formal@none@1@S@All GenBank proteins were downloaded from ftp://ftp.ncbi.nih.gov/blast/DB/fasta/nr (February 2004) and were combined into a single set with the identified Transib TPases.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "downloade") (:form . "downloaded") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ftp://ftp.ncbi.nih.gov/blast/DB/fasta/nr")\n  (:form . "ftp://ftp.ncbi.nih.gov/blast/DB/fasta/nr") (:end . 82)\n  (:start . 42) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "February") (:form . "February") (:end . 92)\n  (:start . 84) (:id . 50))\n ((:tag . "CD") (:stem . "2004") (:form . "2004") (:end . 97) (:start . 93)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 98) (:start . 97)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 107) (:start . 103)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 116)\n  (:start . 108) (:id . 55))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 121) (:start . 117)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 130)\n  (:start . 124) (:id . 58))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 134) (:start . 131)\n  (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 154)\n  (:start . 144) (:id . 62))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 162)\n  (:start . 155) (:id . 63))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 169)\n  (:start . 163) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s6.307) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102047@unknown@formal@none@1@S@No Transib TPases had been deposited or annotated previously in GenBank, except for two short hypothetical proteins predicted automatically during annotation of the D. melanogaster genome: 151-aa gi:30923617 and 123-aa gi:30923765.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 17) (:start . 11)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "deposit") (:form . "deposited") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "annotate") (:form . "annotated") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 60)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 93) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "hypothetical") (:form . "hypothetical") (:end . 106)\n  (:start . 94) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 115)\n  (:start . 107) (:id . 59))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 125)\n  (:start . 116) (:id . 60))\n ((:tag . "RB") (:stem . "automatically") (:form . "automatically")\n  (:end . 139) (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 146)\n  (:start . 140) (:id . 62))\n ((:tag . "NN") (:stem . "annotation") (:form . "annotation") (:end . 157)\n  (:start . 147) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 180)\n  (:start . 168) (:id . 67))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 187)\n  (:start . 181) (:id . 68))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 188) (:start . 187)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "151-aa") (:form . "151-aa") (:end . 195)\n  (:start . 189) (:id . 70))\n ((:tag . "CD") (:stem . "gi:30923617") (:form . "gi:30923617") (:end . 207)\n  (:start . 196) (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 211) (:start . 208)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "123-aa") (:form . "123-aa") (:end . 218)\n  (:start . 212) (:id . 73))\n ((:tag . "CD") (:stem . "gi:30923765") (:form . "gi:30923765") (:end . 230)\n  (:start . 219) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 75)))@@@1@34@((:ncues ((:id . :x6.308.1) (:span 0 2)))\n (:nscopes ((:id . :x6.308.1) (:span 0 71)))\n (:identifiers (:sid . :s6.308) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102048@unknown@formal@none@1@S@These proteins are apparent fragments of Transib TPases encoded by relics of Transib transposons, including Transib5_DM.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 37)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 48)\n  (:start . 41) (:id . 48))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 55) (:start . 49)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 63)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "relic") (:form . "relics") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 84)\n  (:start . 77) (:id . 54))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 107)\n  (:start . 98) (:id . 57))\n ((:tag . "NNP") (:stem . "Transib5_DM") (:form . "Transib5_DM") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.309) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102050@unknown@formal@none@1@S@The PSI-BLAST program [18,45] is much more sensitive than a regular BLAST search due to the use of PSSM) PSI-BLAST first performs a standard BLASTP search of a protein query against a protein database and constructs a multiple alignment of matches exceeding a certain E-value threshold (called Ei value for the inclusion of sequences into PSI-BLAST iterations).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 23) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "18,45") (:form . "18,45") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 37) (:start . 33)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 52)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 57) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "regular") (:form . "regular") (:end . 67)\n  (:start . 60) (:id . 54))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 80)\n  (:start . 74) (:id . 56))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 103) (:start . 99)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 114)\n  (:start . 105) (:id . 64))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 120)\n  (:start . 115) (:id . 65))\n ((:tag . "VBZ") (:stem . "perform") (:form . "performs") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 140)\n  (:start . 132) (:id . 68))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 147)\n  (:start . 141) (:id . 69))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 154)\n  (:start . 148) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 157) (:start . 155)\n  (:id . 71))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 159) (:start . 158)\n  (:id . 72))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 167)\n  (:start . 160) (:id . 73))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 173)\n  (:start . 168) (:id . 74))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 183) (:start . 182)\n  (:id . 76))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 191)\n  (:start . 184) (:id . 77))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 200)\n  (:start . 192) (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "construct") (:form . "constructs") (:end . 215)\n  (:start . 205) (:id . 80))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 217) (:start . 216)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 226)\n  (:start . 218) (:id . 82))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 236)\n  (:start . 227) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 239) (:start . 237)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "match") (:form . "matches") (:end . 247)\n  (:start . 240) (:id . 85))\n ((:tag . "VBG") (:stem . "exceed") (:form . "exceeding") (:end . 257)\n  (:start . 248) (:id . 86))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 259) (:start . 258)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 267)\n  (:start . 260) (:id . 88))\n ((:tag . "NNP") (:stem . "E-value") (:form . "E-value") (:end . 275)\n  (:start . 268) (:id . 89))\n ((:tag . "NN") (:stem . "threshold") (:form . "threshold") (:end . 285)\n  (:start . 276) (:id . 90))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 287) (:start . 286)\n  (:id . 91))\n ((:tag . "VBN") (:stem . "call") (:form . "called") (:end . 293)\n  (:start . 287) (:id . 92))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 296) (:start . 294)\n  (:id . 93))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 302)\n  (:start . 297) (:id . 94))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 306) (:start . 303)\n  (:id . 95))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 310) (:start . 307)\n  (:id . 96))\n ((:tag . "NN") (:stem . "inclusion") (:form . "inclusion") (:end . 320)\n  (:start . 311) (:id . 97))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 323) (:start . 321)\n  (:id . 98))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 333)\n  (:start . 324) (:id . 99))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 338) (:start . 334)\n  (:id . 100))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 348)\n  (:start . 339) (:id . 101))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 359)\n  (:start . 349) (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 360) (:start . 359)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 361) (:start . 360)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s6.311) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102051@unknown@formal@none@1@S@From this alignment, a PSSM is constructed.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "construct") (:form . "constructed") (:end . 42)\n  (:start . 31) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 43) (:start . 42)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.312) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102052@unknown@formal@none@1@S@The PSSM is a weight matrix indicating the relative occurrence of each of the 20 aa at each position in the alignment.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PSSM") (:form . "PSSM") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 20)\n  (:start . 14) (:id . 46))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "relative") (:form . "relative") (:end . 51)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "occurrence") (:form . "occurrence") (:end . 62)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "position") (:form . "position") (:end . 100)\n  (:start . 92) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 117)\n  (:start . 108) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.313) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102053@unknown@formal@none@1@S@This new PSSM is used as the score matrix for a new BLAST search in a second iteration.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NN") (:stem . "score") (:form . "score") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 41)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 47) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 51) (:start . 48)\n  (:id . 53))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 57) (:start . 52)\n  (:id . 54))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 64)\n  (:start . 58) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 69) (:start . 68)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 76)\n  (:start . 70) (:id . 58))\n ((:tag . "NN") (:stem . "iteration") (:form . "iteration") (:end . 86)\n  (:start . 77) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s6.314) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102054@unknown@formal@none@1@S@The process is repeated for a specific number of iterations or until convergence, when no additional proteins are added on successive iterations.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "until") (:form . "until") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "convergence") (:form . "convergence") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 100)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 109)\n  (:start . 101) (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 119) (:start . 114)\n  (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 122) (:start . 120)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "successive") (:form . "successive") (:end . 133)\n  (:start . 123) (:id . 63))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 144)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 65)))@@@1@24@((:ncues ((:id . :x6.315.1) (:span 87 89)))\n (:nscopes ((:id . :x6.315.1) (:span 87 144)))\n (:identifiers (:sid . :s6.315) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102055@unknown@formal@none@1@S@The use of a PSSM in place of a fixed generic substitution matrix such as BLOSUM62 results in a much more sensitive BLAST search [18,45].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pssm") (:form . "PSSM") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 26) (:start . 21)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 31) (:start . 30)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "fixed") (:form . "fixed") (:end . 37) (:start . 32)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "generic") (:form . "generic") (:end . 45)\n  (:start . 38) (:id . 52))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 58)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 65)\n  (:start . 59) (:id . 54))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "blosum62") (:form . "BLOSUM62") (:end . 82)\n  (:start . 74) (:id . 57))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 90)\n  (:start . 83) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 105) (:start . 101)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 115)\n  (:start . 106) (:id . 63))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 121)\n  (:start . 116) (:id . 64))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 128)\n  (:start . 122) (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 130) (:start . 129)\n  (:id . 66))\n ((:tag . "CD") (:stem . "18,45") (:form . "18,45") (:end . 135)\n  (:start . 130) (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 136) (:start . 135)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.316) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102056@unknown@formal@none@1@S@Important practical aspects of using PSI-BLAST were recently described [46].@(((:tag . "JJ") (:stem . "important") (:form . "Important") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "practical") (:form . "practical") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 27)\n  (:start . 20) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 36) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 46)\n  (:start . 37) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 51) (:start . 47)\n  (:id . 48))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 60)\n  (:start . 52) (:id . 49))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 72) (:start . 71)\n  (:id . 51))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.317) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102057@unknown@formal@none@1@S@To ensure that a conservation profile for the Transib TPases and RAG1 proteins was not produced by a systematic error, we employed a procedure of “step-wise” PSI-BLAST iterations.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "ensure") (:form . "ensure") (:end . 9) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "conservation") (:form . "conservation") (:end . 29)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "profile") (:form . "profile") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 60) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 95)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "systematic") (:form . "systematic") (:end . 111)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "employ") (:form . "employed") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 132) (:start . 131)\n  (:id . 65))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 142)\n  (:start . 133) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 67))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "step-wise") (:form . "step-wise") (:end . 156)\n  (:start . 147) (:id . 69))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 157) (:start . 156)\n  (:id . 70))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 167)\n  (:start . 158) (:id . 71))\n ((:tag . "NNS") (:stem . "iteration") (:form . "iterations") (:end . 178)\n  (:start . 168) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x6.318.1) (:span 83 86)))\n (:nscopes ((:id . :x6.318.1) (:span 15 117)))\n (:identifiers (:sid . :s6.318) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102058@unknown@formal@none@1@S@In this procedure we studied dependence of Ei values on the number of the Transib TPases combined with the GenBank proteins.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "study") (:form . "studied") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "dependence") (:form . "dependence") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ei") (:form . "Ei") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "value") (:form . "values") (:end . 52)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NNS") (:stem . "tpas") (:form . "TPases") (:end . 88) (:start . 82)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "combine") (:form . "combined") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 114)\n  (:start . 107) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s6.319) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102060@unknown@formal@none@1@S@Significant convergence of RAG1 and Transib TPases was observed to be independent of the particular type of substitution matrix (the same result was observed for both BLOSUM62 and PAM70 matrixes).@(((:tag . "JJ") (:stem . "significant") (:form . "Significant") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "convergence") (:form . "convergence") (:end . 23)\n  (:start . 12) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "TPas") (:form . "TPases") (:end . 50) (:start . 44)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 63)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 120)\n  (:start . 108) (:id . 59))\n ((:tag . "NN") (:stem . "matrix") (:form . "matrix") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 129) (:start . 128)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 137) (:start . 133)\n  (:id . 63))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 144)\n  (:start . 138) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 148) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 157)\n  (:start . 149) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 161) (:start . 158)\n  (:id . 67))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 166) (:start . 162)\n  (:id . 68))\n ((:tag . "NN") (:stem . "blosum62") (:form . "BLOSUM62") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "pam70") (:form . "PAM70") (:end . 185)\n  (:start . 180) (:id . 71))\n ((:tag . "NNS") (:stem . "matrix") (:form . "matrixes") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 195) (:start . 194)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s6.321) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102061@unknown@formal@none@1@S@To avoid detection of false similarities caused by simple repeats and coiled coils, the PSI-BLAST search was performed using stringent conditions with the SEG [47] and COILS [48] filters masking all low-complexity regions and coiled coils, respectively; composition-based statistics [45] were also employed.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "avoid") (:form . "avoid") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "false") (:form . "false") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "similarity") (:form . "similarities") (:end . 40)\n  (:start . 28) (:id . 47))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "simple") (:form . "simple") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 65)\n  (:start . 58) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "coil") (:form . "coiled") (:end . 76) (:start . 70)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "coil") (:form . "coils") (:end . 82) (:start . 77)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "psi-blast") (:form . "PSI-BLAST") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 124) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "stringent") (:form . "stringent") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 145)\n  (:start . 135) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "SEG") (:form . "SEG") (:end . 158) (:start . 155)\n  (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 160) (:start . 159)\n  (:id . 67))\n ((:tag . "CD") (:stem . "47") (:form . "47") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 167) (:start . 164)\n  (:id . 70))\n ((:tag . "NN") (:stem . "coils") (:form . "COILS") (:end . 173)\n  (:start . 168) (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 175) (:start . 174)\n  (:id . 72))\n ((:tag . "CD") (:stem . "48") (:form . "48") (:end . 177) (:start . 175)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 178) (:start . 177)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "filter") (:form . "filters") (:end . 186)\n  (:start . 179) (:id . 75))\n ((:tag . "VBG") (:stem . "mask") (:form . "masking") (:end . 194)\n  (:start . 187) (:id . 76))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 198) (:start . 195)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "low-complexity") (:form . "low-complexity")\n  (:end . 213) (:start . 199) (:id . 78))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 221)\n  (:start . 214) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 80))\n ((:tag . "VBD") (:stem . "coil") (:form . "coiled") (:end . 232)\n  (:start . 226) (:id . 81))\n ((:tag . "NNS") (:stem . "coil") (:form . "coils") (:end . 238)\n  (:start . 233) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 83))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 252)\n  (:start . 240) (:id . 84))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 253) (:start . 252)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "composition-based") (:form . "composition-based")\n  (:end . 271) (:start . 254) (:id . 86))\n ((:tag . "NNS") (:stem . "statistic") (:form . "statistics") (:end . 282)\n  (:start . 272) (:id . 87))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 284) (:start . 283)\n  (:id . 88))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 286) (:start . 284)\n  (:id . 89))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 287) (:start . 286)\n  (:id . 90))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 292) (:start . 288)\n  (:id . 91))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 297) (:start . 293)\n  (:id . 92))\n ((:tag . "VBN") (:stem . "employ") (:form . "employed") (:end . 306)\n  (:start . 298) (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 307) (:start . 306)\n  (:id . 94)))@@@1@53@((:identifiers (:sid . :s6.322) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102062@unknown@formal@none@1@S@The probability P1 that the 5? terminus of a transposon from a particular Transib family would match by chance an RSS at its most conserved positions (positions 1-3 in the RSS heptamer, and positions 5 and 6 in the RSS nonamer) was estimated based on the following formula: P1 = fC × fA × fC × fA × fA, where fC (0.2) and fA (0.3) are frequencies of C and A in a set of 38-bp 5? termini of Transib transposons from 21 families (see Figure 4).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "probability") (:form . "probability") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "p1") (:form . "P1") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 55)\n  (:start . 45) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "particular") (:form . "particular") (:end . 73)\n  (:start . 63) (:id . 55))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 81)\n  (:start . 74) (:id . 56))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 88)\n  (:start . 82) (:id . 57))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 94) (:start . 89)\n  (:id . 58))\n ((:tag . "VB") (:stem . "match") (:form . "match") (:end . 100) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 110)\n  (:start . 104) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NN") (:stem . "rss") (:form . "RSS") (:end . 117) (:start . 114)\n  (:id . 63))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 139)\n  (:start . 130) (:id . 67))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 149)\n  (:start . 140) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 160)\n  (:start . 151) (:id . 70))\n ((:tag . "CD") (:stem . "1-3") (:form . "1-3") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 167) (:start . 165)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 175) (:start . 172)\n  (:id . 74))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 184)\n  (:start . 176) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 199)\n  (:start . 190) (:id . 78))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 201) (:start . 200)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 205) (:start . 202)\n  (:id . 80))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 207) (:start . 206)\n  (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 83))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 218) (:start . 215)\n  (:id . 84))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 226)\n  (:start . 219) (:id . 85))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 227) (:start . 226)\n  (:id . 86))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 231) (:start . 228)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "estimate") (:form . "estimated") (:end . 241)\n  (:start . 232) (:id . 88))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 247)\n  (:start . 242) (:id . 89))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 250) (:start . 248)\n  (:id . 90))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 254) (:start . 251)\n  (:id . 91))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 264)\n  (:start . 255) (:id . 92))\n ((:tag . "NN") (:stem . "formula") (:form . "formula") (:end . 272)\n  (:start . 265) (:id . 93))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 273) (:start . 272)\n  (:id . 94))\n ((:tag . "NNP") (:stem . "P1") (:form . "P1") (:end . 276) (:start . 274)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "=") (:form . "=") (:end . 278) (:start . 277)\n  (:id . 96))\n ((:tag . "NN") (:stem . "fc") (:form . "fC") (:end . 281) (:start . 279)\n  (:id . 97))\n ((:tag . "NN") (:stem . "×") (:form . "×") (:end . 283) (:start . 282)\n  (:id . 98))\n ((:tag . "NN") (:stem . "fa") (:form . "fA") (:end . 286) (:start . 284)\n  (:id . 99))\n ((:tag . "NNP") (:stem . "×") (:form . "×") (:end . 288) (:start . 287)\n  (:id . 100))\n ((:tag . "NN") (:stem . "fc") (:form . "fC") (:end . 291) (:start . 289)\n  (:id . 101))\n ((:tag . "NNP") (:stem . "×") (:form . "×") (:end . 293) (:start . 292)\n  (:id . 102))\n ((:tag . "NNP") (:stem . "fA") (:form . "fA") (:end . 296) (:start . 294)\n  (:id . 103))\n ((:tag . "NNP") (:stem . "×") (:form . "×") (:end . 298) (:start . 297)\n  (:id . 104))\n ((:tag . "NNP") (:stem . "fA") (:form . "fA") (:end . 301) (:start . 299)\n  (:id . 105))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 302) (:start . 301)\n  (:id . 106))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 308)\n  (:start . 303) (:id . 107))\n ((:tag . "NN") (:stem . "fc") (:form . "fC") (:end . 311) (:start . 309)\n  (:id . 108))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 313) (:start . 312)\n  (:id . 109))\n ((:tag . "CD") (:stem . "0.2") (:form . "0.2") (:end . 316) (:start . 313)\n  (:id . 110))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 317) (:start . 316)\n  (:id . 111))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 321) (:start . 318)\n  (:id . 112))\n ((:tag . "NNP") (:stem . "fA") (:form . "fA") (:end . 324) (:start . 322)\n  (:id . 113))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 326) (:start . 325)\n  (:id . 114))\n ((:tag . "CD") (:stem . "0.3") (:form . "0.3") (:end . 329) (:start . 326)\n  (:id . 115))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 330) (:start . 329)\n  (:id . 116))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 334) (:start . 331)\n  (:id . 117))\n ((:tag . "NNS") (:stem . "frequency") (:form . "frequencies") (:end . 346)\n  (:start . 335) (:id . 118))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 349) (:start . 347)\n  (:id . 119))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 351) (:start . 350)\n  (:id . 120))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 355) (:start . 352)\n  (:id . 121))\n ((:tag . "NN") (:stem . "a") (:form . "A") (:end . 357) (:start . 356)\n  (:id . 122))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 360) (:start . 358)\n  (:id . 123))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 362) (:start . 361)\n  (:id . 124))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 366) (:start . 363)\n  (:id . 125))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 369) (:start . 367)\n  (:id . 126))\n ((:tag . "JJ") (:stem . "38-bp") (:form . "38-bp") (:end . 375)\n  (:start . 370) (:id . 127))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 377) (:start . 376)\n  (:id . 128))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 378) (:start . 377)\n  (:id . 129))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 386)\n  (:start . 379) (:id . 130))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 389) (:start . 387)\n  (:id . 131))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 397)\n  (:start . 390) (:id . 132))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 409)\n  (:start . 398) (:id . 133))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 414) (:start . 410)\n  (:id . 134))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 417) (:start . 415)\n  (:id . 135))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 426)\n  (:start . 418) (:id . 136))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 428) (:start . 427)\n  (:id . 137))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 431) (:start . 428)\n  (:id . 138))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 438)\n  (:start . 432) (:id . 139))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 440) (:start . 439)\n  (:id . 140))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 441) (:start . 440)\n  (:id . 141))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 442) (:start . 441)\n  (:id . 142)))@@@1@101@((:identifiers (:sid . :s6.323) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102063@unknown@formal@none@1@S@The value of P1 is 0.001, indicating a significant similarity between Transib TIRs and RSS.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "value") (:form . "value") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "P1") (:form . "P1") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "CD") (:stem . "0.001") (:form . "0.001") (:end . 24) (:start . 19)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 36)\n  (:start . 26) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 50)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "NNPS") (:stem . "TIR") (:form . "TIRs") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.324) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102064@unknown@formal@none@1@S@Indeed, given that these five positions conserved in RSS are conserved in all TIRs from 21 families of Transib transposons, and the average identity between these 38-bp TIRs is only 49%, the chance of randomly matching these positions in TIRs from all 21 families is extremely small.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 24) (:start . 19)\n  (:id . 46))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rss") (:form . "RSS") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 70)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 99)\n  (:start . 91) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 110)\n  (:start . 103) (:id . 61))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 122)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "average") (:form . "average") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 148)\n  (:start . 140) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 156)\n  (:start . 149) (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 162)\n  (:start . 157) (:id . 69))\n ((:tag . "JJ") (:stem . "38-bp") (:form . "38-bp") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 173) (:start . 169)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 176) (:start . 174)\n  (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 181) (:start . 177)\n  (:id . 73))\n ((:tag . "CD") (:stem . "49") (:form . "49") (:end . 184) (:start . 182)\n  (:id . 74))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 185) (:start . 184)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 77))\n ((:tag . "NN") (:stem . "chance") (:form . "chance") (:end . 197)\n  (:start . 191) (:id . 78))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 79))\n ((:tag . "RB") (:stem . "randomly") (:form . "randomly") (:end . 209)\n  (:start . 201) (:id . 80))\n ((:tag . "VBG") (:stem . "match") (:form . "matching") (:end . 218)\n  (:start . 210) (:id . 81))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 224)\n  (:start . 219) (:id . 82))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 234)\n  (:start . 225) (:id . 83))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 237) (:start . 235)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "tir") (:form . "TIRs") (:end . 242) (:start . 238)\n  (:id . 85))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 247) (:start . 243)\n  (:id . 86))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 251) (:start . 248)\n  (:id . 87))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 254) (:start . 252)\n  (:id . 88))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 263)\n  (:start . 255) (:id . 89))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 266) (:start . 264)\n  (:id . 90))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 276)\n  (:start . 267) (:id . 91))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 282)\n  (:start . 277) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 283) (:start . 282)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s6.325) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102065@unknown@formal@none@1@S@TBLASTN searches against the Trace Archive were performed by using the BLAST client (blastcl3 or netblast at ftp://ftp.ncbi.nlm.nih.gov/blast/executables/LATEST/, which accesses the NCBI BLAST search engine.@(((:tag . "NNP") (:stem . "TBLASTN") (:form . "TBLASTN") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "search") (:form . "searches") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Archive") (:form . "Archive") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 57)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 66) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "blast") (:form . "BLAST") (:end . 76) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "client") (:form . "client") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "blastcl3") (:form . "blastcl3") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "netblast") (:form . "netblast") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NNP")\n  (:stem . "ftp://ftp.ncbi.nlm.nih.gov/blast/executables/LATEST/")\n  (:form . "ftp://ftp.ncbi.nlm.nih.gov/blast/executables/LATEST/")\n  (:end . 161) (:start . 109) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 162) (:start . 161)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 168)\n  (:start . 163) (:id . 62))\n ((:tag . "VBZ") (:stem . "access") (:form . "accesses") (:end . 177)\n  (:start . 169) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "NCBI") (:form . "NCBI") (:end . 186) (:start . 182)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "BLAST") (:form . "BLAST") (:end . 192)\n  (:start . 187) (:id . 66))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 199)\n  (:start . 193) (:id . 67))\n ((:tag . "NN") (:stem . "engine") (:form . "engine") (:end . 206)\n  (:start . 200) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 207) (:start . 206)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s6.326) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102066@unknown@formal@none@1@S@Names of all available Trace Databases were taken from a list of databases at http://www.ncbi.nlm.nih.gov/blast/mmtrace.shtml.@(((:tag . "NNS") (:stem . "name") (:form . "Names") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "available") (:form . "available") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "NNPS") (:stem . "Database") (:form . "Databases") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "take") (:form . "taken") (:end . 49) (:start . 44)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "list") (:form . "list") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "database") (:form . "databases") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "NN") (:stem . "http://www.ncbi.nlm.nih.gov/blast/mmtrace.shtml")\n  (:form . "http://www.ncbi.nlm.nih.gov/blast/mmtrace.shtml") (:end . 125)\n  (:start . 78) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s6.327) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102067@unknown@formal@none@1@S@Preferential Insertion of Transib transposons into GC-Rich Sites@(((:tag . "JJ") (:stem . "preferential") (:form . "Preferential") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "insertion") (:form . "Insertion") (:end . 22)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 33)\n  (:start . 26) (:id . 45))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 45)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 50) (:start . 46)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "gc-rich") (:form . "GC-Rich") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "NNPS") (:stem . "Site") (:form . "Sites") (:end . 64) (:start . 59)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.328) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5102068@unknown@formal@none@1@S@Each of the 35-bp insertion sites corresponds to two 20-bp DNA fragments flanking a genomic Transib element at its 5? and 3? termini.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "35-bp") (:form . "35-bp") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "20-bp") (:form . "20-bp") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 72)\n  (:start . 63) (:id . 53))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 99)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 63))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 132)\n  (:start . 125) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.329) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102070@unknown@formal@none@1@S@Analogously, the 15-bp insertion sites were composed of two 10-bp flanking fragm.@(((:tag . "RB") (:stem . "analogously") (:form . "Analogously") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "15-bp") (:form . "15-bp") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "10-bp") (:form . "10-bp") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "flanking") (:form . "flanking") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "NN") (:stem . "fragm") (:form . "fragm") (:end . 80) (:start . 75)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 81) (:start . 80)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s6.331) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102071@unknown@formal@none@1@S@Supporting Information@(((:tag . "VBG") (:stem . "support") (:form . "Supporting") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Information") (:form . "Information") (:end . 22)\n  (:start . 11) (:id . 43)))@@@1@2@((:identifiers (:sid . :s6.332) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102072@unknown@formal@none@1@S@Similarity between C-Terminal Portions of the Transib2_AG TPase and RAG1@(((:tag . "NN") (:stem . "similarity") (:form . "Similarity") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 18)\n  (:start . 11) (:id . 43))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-Terminal") (:end . 29)\n  (:start . 19) (:id . 44))\n ((:tag . "NNPS") (:stem . "Portion") (:form . "Portions") (:end . 38)\n  (:start . 30) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 57)\n  (:start . 46) (:id . 48))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 63) (:start . 58)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 72) (:start . 68)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.333) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102073@unknown@formal@none@1@S@Two examples extracted from the NCBI BLASTP output illustrate similarity between the approximately 60-aa C-terminal portions of the Transib2_AG TPase (which we used as a query in a BLASTP search against all GenBank proteins) and the RAG1 core.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "example") (:form . "examples") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBN") (:stem . "extract") (:form . "extracted") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "NCBI") (:form . "NCBI") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "output") (:form . "output") (:end . 50)\n  (:start . 44) (:id . 49))\n ((:tag . "VBP") (:stem . "illustrate") (:form . "illustrate") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 72)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 80)\n  (:start . 73) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 98) (:start . 85) (:id . 54))\n ((:tag . "JJ") (:stem . "60-aa") (:form . "60-aa") (:end . 104) (:start . 99)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "c-terminal") (:form . "C-terminal") (:end . 115)\n  (:start . 105) (:id . 56))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 124)\n  (:start . 116) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Transib2_AG") (:form . "Transib2_AG") (:end . 143)\n  (:start . 132) (:id . 60))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 149)\n  (:start . 144) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 151) (:start . 150)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 156)\n  (:start . 151) (:id . 63))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 164) (:start . 160)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 169) (:start . 168)\n  (:id . 67))\n ((:tag . "NN") (:stem . "query") (:form . "query") (:end . 175)\n  (:start . 170) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 69))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 180) (:start . 179)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "BLASTP") (:form . "BLASTP") (:end . 187)\n  (:start . 181) (:id . 71))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 194)\n  (:start . 188) (:id . 72))\n ((:tag . "IN") (:stem . "against") (:form . "against") (:end . 202)\n  (:start . 195) (:id . 73))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 206) (:start . 203)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 214)\n  (:start . 207) (:id . 75))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 223)\n  (:start . 215) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 224) (:start . 223)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 79))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 237) (:start . 233)\n  (:id . 80))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 242) (:start . 238)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s6.334) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102074@unknown@formal@none@1@S@Multiple Alignment of Transib TPases@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "Alignment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "NNPS") (:stem . "TPas") (:form . "TPases") (:end . 36)\n  (:start . 30) (:id . 46)))@@@1@5@((:identifiers (:sid . :s6.335) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102075@unknown@formal@none@1@S@The catalytic DDE triad is marked by black rectangles.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "dde") (:form . "DDE") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 33) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.336) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102076@unknown@formal@none@1@S@Amino acids are shaded on the basis of their physiochemical properties according to the color scheme implemented in Genedoc [43]: Black shading marks hydrophobic residues, blue indicates charged (white font), positively charged (red font), and negatively charged (green font); red indicates proline (blue font) and glycine (green font); gray indicates aliphatic (red font) and aromatic (blue font); green indicates polar (black font) and amphoteric (red font); yellow indicates tiny (blue font) and small (green font).@(((:tag . "NN") (:stem . "amino") (:form . "Amino") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "shade") (:form . "shaded") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 44)\n  (:start . 39) (:id . 50))\n ((:tag . "JJ") (:stem . "physiochemical") (:form . "physiochemical")\n  (:end . 59) (:start . 45) (:id . 51))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 70)\n  (:start . 60) (:id . 52))\n ((:tag . "VBG") (:stem . "accord") (:form . "according") (:end . 80)\n  (:start . 71) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NN") (:stem . "color") (:form . "color") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "VBN") (:stem . "implement") (:form . "implemented") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Genedoc") (:form . "Genedoc") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 125) (:start . 124)\n  (:id . 61))\n ((:tag . "CD") (:stem . "43") (:form . "43") (:end . 127) (:start . 125)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 128) (:start . 127)\n  (:id . 63))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "black") (:form . "Black") (:end . 135)\n  (:start . 130) (:id . 65))\n ((:tag . "VBG") (:stem . "shade") (:form . "shading") (:end . 143)\n  (:start . 136) (:id . 66))\n ((:tag . "NNS") (:stem . "mark") (:form . "marks") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "JJ") (:stem . "hydrophobic") (:form . "hydrophobic") (:end . 161)\n  (:start . 150) (:id . 68))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 176) (:start . 172)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 186)\n  (:start . 177) (:id . 72))\n ((:tag . "VBN") (:stem . "charge") (:form . "charged") (:end . 194)\n  (:start . 187) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 201)\n  (:start . 196) (:id . 75))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 206) (:start . 202)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 78))\n ((:tag . "RB") (:stem . "positively") (:form . "positively") (:end . 219)\n  (:start . 209) (:id . 79))\n ((:tag . "VBN") (:stem . "charge") (:form . "charged") (:end . 227)\n  (:start . 220) (:id . 80))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 229) (:start . 228)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 232) (:start . 229)\n  (:id . 82))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 237) (:start . 233)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 238) (:start . 237)\n  (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 243) (:start . 240)\n  (:id . 86))\n ((:tag . "RB") (:stem . "negatively") (:form . "negatively") (:end . 254)\n  (:start . 244) (:id . 87))\n ((:tag . "VBN") (:stem . "charge") (:form . "charged") (:end . 262)\n  (:start . 255) (:id . 88))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 264) (:start . 263)\n  (:id . 89))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 269)\n  (:start . 264) (:id . 90))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 274) (:start . 270)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 275) (:start . 274)\n  (:id . 92))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 276) (:start . 275)\n  (:id . 93))\n ((:tag . "NN") (:stem . "red") (:form . "red") (:end . 280) (:start . 277)\n  (:id . 94))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 290)\n  (:start . 281) (:id . 95))\n ((:tag . "NN") (:stem . "proline") (:form . "proline") (:end . 298)\n  (:start . 291) (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 300) (:start . 299)\n  (:id . 97))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 304) (:start . 300)\n  (:id . 98))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 309) (:start . 305)\n  (:id . 99))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 310) (:start . 309)\n  (:id . 100))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 314) (:start . 311)\n  (:id . 101))\n ((:tag . "NN") (:stem . "glycine") (:form . "glycine") (:end . 322)\n  (:start . 315) (:id . 102))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 324) (:start . 323)\n  (:id . 103))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 329)\n  (:start . 324) (:id . 104))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 334) (:start . 330)\n  (:id . 105))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 335) (:start . 334)\n  (:id . 106))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 336) (:start . 335)\n  (:id . 107))\n ((:tag . "NN") (:stem . "gray") (:form . "gray") (:end . 341) (:start . 337)\n  (:id . 108))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 351)\n  (:start . 342) (:id . 109))\n ((:tag . "JJ") (:stem . "aliphatic") (:form . "aliphatic") (:end . 361)\n  (:start . 352) (:id . 110))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 363) (:start . 362)\n  (:id . 111))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 366) (:start . 363)\n  (:id . 112))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 371) (:start . 367)\n  (:id . 113))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 372) (:start . 371)\n  (:id . 114))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 376) (:start . 373)\n  (:id . 115))\n ((:tag . "JJ") (:stem . "aromatic") (:form . "aromatic") (:end . 385)\n  (:start . 377) (:id . 116))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 387) (:start . 386)\n  (:id . 117))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 391) (:start . 387)\n  (:id . 118))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 396) (:start . 392)\n  (:id . 119))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 397) (:start . 396)\n  (:id . 120))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 398) (:start . 397)\n  (:id . 121))\n ((:tag . "NN") (:stem . "green") (:form . "green") (:end . 404)\n  (:start . 399) (:id . 122))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 414)\n  (:start . 405) (:id . 123))\n ((:tag . "JJ") (:stem . "polar") (:form . "polar") (:end . 420)\n  (:start . 415) (:id . 124))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 422) (:start . 421)\n  (:id . 125))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 427)\n  (:start . 422) (:id . 126))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 432) (:start . 428)\n  (:id . 127))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 433) (:start . 432)\n  (:id . 128))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 437) (:start . 434)\n  (:id . 129))\n ((:tag . "JJ") (:stem . "amphoteric") (:form . "amphoteric") (:end . 448)\n  (:start . 438) (:id . 130))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 450) (:start . 449)\n  (:id . 131))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 453) (:start . 450)\n  (:id . 132))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 458) (:start . 454)\n  (:id . 133))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 459) (:start . 458)\n  (:id . 134))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 460) (:start . 459)\n  (:id . 135))\n ((:tag . "NN") (:stem . "yellow") (:form . "yellow") (:end . 467)\n  (:start . 461) (:id . 136))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 477)\n  (:start . 468) (:id . 137))\n ((:tag . "JJ") (:stem . "tiny") (:form . "tiny") (:end . 482) (:start . 478)\n  (:id . 138))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 484) (:start . 483)\n  (:id . 139))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 488) (:start . 484)\n  (:id . 140))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 493) (:start . 489)\n  (:id . 141))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 494) (:start . 493)\n  (:id . 142))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 498) (:start . 495)\n  (:id . 143))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 504)\n  (:start . 499) (:id . 144))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 506) (:start . 505)\n  (:id . 145))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 511)\n  (:start . 506) (:id . 146))\n ((:tag . "NN") (:stem . "font") (:form . "font") (:end . 516) (:start . 512)\n  (:id . 147))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 517) (:start . 516)\n  (:id . 148))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 518) (:start . 517)\n  (:id . 149)))@@@1@108@((:identifiers (:sid . :s6.337) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102077@unknown@formal@none@1@S@The species abbreviations are as follows: SP, sea urchin; DP, D. pseudoobscura fruit fly; AG, African malaria mosquito; AA, yellow fever mosquito.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 64) (:start . 62)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 78) (:start . 65) (:id . 57))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 84) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "AG") (:form . "AG") (:end . 92) (:start . 90)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 101)\n  (:start . 94) (:id . 63))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 109)\n  (:start . 102) (:id . 64))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 118)\n  (:start . 110) (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 119) (:start . 118)\n  (:id . 66))\n ((:tag . "NN") (:stem . "aa") (:form . "AA") (:end . 122) (:start . 120)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 130)\n  (:start . 124) (:id . 69))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 136)\n  (:start . 131) (:id . 70))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 145)\n  (:start . 137) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 146) (:start . 145)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s6.338) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102078@unknown@formal@none@1@S@Transib1 through Transib5 are from the D. melanogaster fruit fly genome.@(((:tag . "NN") (:stem . "transib1") (:form . "Transib1") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 16)\n  (:start . 9) (:id . 43))\n ((:tag . "NN") (:stem . "transib5") (:form . "Transib5") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 54)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 71)\n  (:start . 65) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.339) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102080@unknown@formal@none@1@S@The shading scheme is the same as in Figure S2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "shade") (:form . "shading") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "s2") (:form . "S2") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.341) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102081@unknown@formal@none@1@S@The catalytic DDE triad is marked by black rectangles.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "dde") (:form . "DDE") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "triad") (:form . "triad") (:end . 23) (:start . 18)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 33) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 42) (:start . 37)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 53)\n  (:start . 43) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.342) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102082@unknown@formal@none@1@S@RAG1 aa whose replacements resulted in previously detected defects of V(D)J recombination [31] are marked by color rectangles indicated below the alignment blocks; red indicates DNA binding defect; green indicates nicking defect; cyan indicates hairpin defect; blue indicates joining mutants; yellow indicates catalytic mutants; gray indicates joining/transposition.@(((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "aa") (:form . "aa") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "WP$") (:stem . "whose") (:form . "whose") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "replacement") (:form . "replacements") (:end . 26)\n  (:start . 14) (:id . 45))\n ((:tag . "VBD") (:stem . "result") (:form . "resulted") (:end . 35)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 58)\n  (:start . 50) (:id . 49))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 66)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 75) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 89) (:start . 76) (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "CD") (:stem . "31") (:form . "31") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 98) (:start . 95)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 108) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "color") (:form . "color") (:end . 114)\n  (:start . 109) (:id . 60))\n ((:tag . "NNS") (:stem . "rectangle") (:form . "rectangles") (:end . 125)\n  (:start . 115) (:id . 61))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 135)\n  (:start . 126) (:id . 62))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "NNS") (:stem . "block") (:form . "blocks") (:end . 162)\n  (:start . 156) (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 163) (:start . 162)\n  (:id . 67))\n ((:tag . "NN") (:stem . "red") (:form . "red") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 177)\n  (:start . 168) (:id . 69))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 181) (:start . 178)\n  (:id . 70))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 189)\n  (:start . 182) (:id . 71))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 196)\n  (:start . 190) (:id . 72))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 197) (:start . 196)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 203)\n  (:start . 198) (:id . 74))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 213)\n  (:start . 204) (:id . 75))\n ((:tag . "NN") (:stem . "nicking") (:form . "nicking") (:end . 221)\n  (:start . 214) (:id . 76))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 228)\n  (:start . 222) (:id . 77))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 229) (:start . 228)\n  (:id . 78))\n ((:tag . "NN") (:stem . "cyan") (:form . "cyan") (:end . 234) (:start . 230)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 244)\n  (:start . 235) (:id . 80))\n ((:tag . "NN") (:stem . "hairpin") (:form . "hairpin") (:end . 252)\n  (:start . 245) (:id . 81))\n ((:tag . "NN") (:stem . "defect") (:form . "defect") (:end . 259)\n  (:start . 253) (:id . 82))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 260) (:start . 259)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 265) (:start . 261)\n  (:id . 84))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 275)\n  (:start . 266) (:id . 85))\n ((:tag . "VBG") (:stem . "join") (:form . "joining") (:end . 283)\n  (:start . 276) (:id . 86))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 291)\n  (:start . 284) (:id . 87))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 292) (:start . 291)\n  (:id . 88))\n ((:tag . "NN") (:stem . "yellow") (:form . "yellow") (:end . 299)\n  (:start . 293) (:id . 89))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 309)\n  (:start . 300) (:id . 90))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 319)\n  (:start . 310) (:id . 91))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 327)\n  (:start . 320) (:id . 92))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 328) (:start . 327)\n  (:id . 93))\n ((:tag . "NN") (:stem . "gray") (:form . "gray") (:end . 333) (:start . 329)\n  (:id . 94))\n ((:tag . "VBZ") (:stem . "indicate") (:form . "indicates") (:end . 343)\n  (:start . 334) (:id . 95))\n ((:tag . "NN") (:stem . "joining/transposition")\n  (:form . "joining/transposition") (:end . 365) (:start . 344) (:id . 96))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 366) (:start . 365)\n  (:id . 97)))@@@1@56@((:identifiers (:sid . :s6.343) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102083@unknown@formal@none@1@S@Presence and absence of corresponding residues in the Transib TPases are indicated by + and -, respectively.@(((:tag . "NNP") (:stem . "Presence") (:form . "Presence") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 37)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 46)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "NNPS") (:stem . "TPas") (:form . "TPases") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "indicate") (:form . "indicated") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 54))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 107)\n  (:start . 95) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:ncues ((:id . :x6.344.1) (:span 13 20)))\n (:nscopes ((:id . :x6.344.1) (:span 13 68)))\n (:identifiers (:sid . :s6.344) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102084@unknown@formal@none@1@S@Conserved motifs are marked by lines numbered from 1 to 10.@(((:tag . "VBN") (:stem . "conserve") (:form . "Conserved") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 16)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 27) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "number") (:form . "numbered") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s6.345) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102085@unknown@formal@none@1@S@The species abbreviations are as follows: DP, D. pseudoobscura fruit fly; AG, African malaria mosquito; AA, yellow fever mosquito; GG, chicken; HS, human; XL, frog; CL, bull shark; FR, fugu fish.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "DP") (:form . "DP") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 48) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 62) (:start . 49) (:id . 52))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 73) (:start . 72)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "AG") (:form . "AG") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 85)\n  (:start . 78) (:id . 58))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 93)\n  (:start . 86) (:id . 59))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 102)\n  (:start . 94) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "aa") (:form . "AA") (:end . 106) (:start . 104)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "yellow") (:form . "yellow") (:end . 114)\n  (:start . 108) (:id . 64))\n ((:tag . "NN") (:stem . "fever") (:form . "fever") (:end . 120)\n  (:start . 115) (:id . 65))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 129)\n  (:start . 121) (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "GG") (:form . "GG") (:end . 133) (:start . 131)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 69))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 142)\n  (:start . 135) (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 143) (:start . 142)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 146) (:start . 144)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 153)\n  (:start . 148) (:id . 74))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 154) (:start . 153)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "XL") (:form . "XL") (:end . 157) (:start . 155)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 77))\n ((:tag . "NN") (:stem . "frog") (:form . "frog") (:end . 163) (:start . 159)\n  (:id . 78))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 164) (:start . 163)\n  (:id . 79))\n ((:tag . "NNP") (:stem . "CL") (:form . "CL") (:end . 167) (:start . 165)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 81))\n ((:tag . "NN") (:stem . "bull") (:form . "bull") (:end . 173) (:start . 169)\n  (:id . 82))\n ((:tag . "NN") (:stem . "shark") (:form . "shark") (:end . 179)\n  (:start . 174) (:id . 83))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 180) (:start . 179)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "FR") (:form . "FR") (:end . 183) (:start . 181)\n  (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 86))\n ((:tag . "NN") (:stem . "fugu") (:form . "fugu") (:end . 189) (:start . 185)\n  (:id . 87))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 194) (:start . 190)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s6.346) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102086@unknown@formal@none@1@S@TSDs in Transposons from Different Transib Families@(((:tag . "NNP") (:stem . "TSD") (:form . "TSDs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "Transposon") (:form . "Transposons") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "family") (:form . "Families") (:end . 51)\n  (:start . 43) (:id . 48)))@@@1@7@((:identifiers (:sid . :s6.347) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102087@unknown@formal@none@1@S@For each family, DNA copies of transposons are aligned to the corresponding consensus sequence.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 27) (:start . 21)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 42)\n  (:start . 31) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 46) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "align") (:form . "aligned") (:end . 54)\n  (:start . 47) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "correspond") (:form . "corresponding") (:end . 75)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 85)\n  (:start . 76) (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s6.348) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102088@unknown@formal@none@1@S@The consensus sequence is shown in the top line.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "top") (:form . "top") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s6.349) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102090@unknown@formal@none@1@S@Internal portions of transposons are not shown and are marked by xxx.@(((:tag . "JJ") (:stem . "internal") (:form . "Internal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "portion") (:form . "portions") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 32)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 61) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "xxx") (:form . "xxx") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 54)))@@@1@13@((:ncues ((:id . :x6.351.1) (:span 37 40)))\n (:nscopes ((:id . :x6.351.1) (:span 0 46)))\n (:identifiers (:sid . :s6.351) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102091@unknown@formal@none@1@S@TSDs are highlighted.@(((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "highlight") (:form . "highlighted") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 21) (:start . 20)\n  (:id . 45)))@@@1@4@((:identifiers (:sid . :s6.352) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102092@unknown@formal@none@1@S@Coordinates of the reported elements are shown in the first two columns (sequence name, beginning to end).@(((:tag . "NNS") (:stem . "coordinate") (:form . "Coordinates") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 14) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "column") (:form . "columns") (:end . 71)\n  (:start . 64) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 81)\n  (:start . 73) (:id . 55))\n ((:tag . "NN") (:stem . "name") (:form . "name") (:end . 86) (:start . 82)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "begin") (:form . "beginning") (:end . 97)\n  (:start . 88) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . "VB") (:stem . "end") (:form . "end") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.353) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102093@unknown@formal@none@1@S@(A) TransibN1_AG family from mosquito.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "TransibN1_AG") (:form . "TransibN1_AG") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.354) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102094@unknown@formal@none@1@S@(B) TransibN2_AG family from mosquito.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "TransibN2_AG") (:form . "TransibN2_AG") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.355) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102095@unknown@formal@none@1@S@(C) TransibN3_AG family from mosquito.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "TransibN3_AG") (:form . "TransibN3_AG") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 38) (:start . 37)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.356) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102096@unknown@formal@none@1@S@(D) TransibN1_DP family from fruit fly.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "TransibN1_DP") (:form . "TransibN1_DP") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.357) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102097@unknown@formal@none@1@S@(E) Hopper family from fruit fly.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "hopper") (:form . "Hopper") (:end . 10) (:start . 4)\n  (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 17)\n  (:start . 11) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 32) (:start . 29)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 33) (:start . 32)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.358) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102098@unknown@formal@none@1@S@(F) TransibN1_DM family from fruit fly.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "F") (:form . "F") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "TransibN1_DM") (:form . "TransibN1_DM") (:end . 16)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 39) (:start . 38)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.359) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102100@unknown@formal@none@1@S@Multiple Alignment of the RAG1 Core and RAG1 Core–Like Proteins Encoded by the Sea Urchin and Lancelet Genomes@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "Alignment") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Core") (:form . "Core") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RAG1") (:form . "RAG1") (:end . 44) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Core–Like") (:form . "Core–Like") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNPS") (:stem . "Protein") (:form . "Proteins") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "VBN") (:stem . "encode") (:form . "Encoded") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 74) (:start . 72)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Urchin") (:form . "Urchin") (:end . 89)\n  (:start . 83) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Lancelet") (:form . "Lancelet") (:end . 102)\n  (:start . 94) (:id . 58))\n ((:tag . "NNPS") (:stem . "Genome") (:form . "Genomes") (:end . 110)\n  (:start . 103) (:id . 59)))@@@1@18@((:identifiers (:sid . :s6.361) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102101@unknown@formal@none@1@S@The shading scheme is the same as in Figure S2 and S3.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "shade") (:form . "shading") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "scheme") (:form . "scheme") (:end . 18)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 43)\n  (:start . 37) (:id . 50))\n ((:tag . "NNP") (:stem . "S2") (:form . "S2") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "S3") (:form . "S3") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.362) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102102@unknown@formal@none@1@S@The species abbreviations are as follows: SP, sea urchin; BF, lancelet; HS, human; CL, bull shark; GG, chicken; XL, frog; FR, fugu fish.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "species") (:form . "species") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "abbreviation") (:form . "abbreviations")\n  (:end . 25) (:start . 12) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 29) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "follow") (:form . "follows") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "SP") (:form . "SP") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 56)\n  (:start . 50) (:id . 52))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 57) (:start . 56)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "BF") (:form . "BF") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 70)\n  (:start . 62) (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 71) (:start . 70)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "HS") (:form . "HS") (:end . 74) (:start . 72)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 81) (:start . 76)\n  (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 82) (:start . 81)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CL") (:form . "CL") (:end . 85) (:start . 83)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 86) (:start . 85)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bull") (:form . "bull") (:end . 91) (:start . 87)\n  (:id . 64))\n ((:tag . "NN") (:stem . "shark") (:form . "shark") (:end . 97) (:start . 92)\n  (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 98) (:start . 97)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "GG") (:form . "GG") (:end . 101) (:start . 99)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 68))\n ((:tag . "NN") (:stem . "chicken") (:form . "chicken") (:end . 110)\n  (:start . 103) (:id . 69))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 111) (:start . 110)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "XL") (:form . "XL") (:end . 114) (:start . 112)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 72))\n ((:tag . "NN") (:stem . "frog") (:form . "frog") (:end . 120) (:start . 116)\n  (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 121) (:start . 120)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "FR") (:form . "FR") (:end . 124) (:start . 122)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 76))\n ((:tag . "NN") (:stem . "fugu") (:form . "fugu") (:end . 130) (:start . 126)\n  (:id . 77))\n ((:tag . "NN") (:stem . "fish") (:form . "fish") (:end . 135) (:start . 131)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s6.363) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102103@unknown@formal@none@1@S@The lancelet RAG1L_BF protein is encoded by several overlapping WGS trace sequences (for example, GenBank Trace Archive identification numbers 543943730, 538583629).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lancelet") (:form . "lancelet") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "rag1l_bf") (:form . "RAG1L_BF") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 29)\n  (:start . 22) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 63)\n  (:start . 52) (:id . 50))\n ((:tag . "NN") (:stem . "wgs") (:form . "WGS") (:end . 67) (:start . 64)\n  (:id . 51))\n ((:tag . "NN") (:stem . "trace") (:form . "trace") (:end . 73) (:start . 68)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 83)\n  (:start . 74) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 96)\n  (:start . 89) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 105)\n  (:start . 98) (:id . 58))\n ((:tag . "NNP") (:stem . "Trace") (:form . "Trace") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNP") (:stem . "Archive") (:form . "Archive") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 134) (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "CD") (:stem . "543943730") (:form . "543943730") (:end . 152)\n  (:start . 143) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 153) (:start . 152)\n  (:id . 64))\n ((:tag . "CD") (:stem . "538583629") (:form . "538583629") (:end . 163)\n  (:start . 154) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 164) (:start . 163)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.364) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102104@unknown@formal@none@1@S@RAG1-Like Protein SP_29068 in the Sea Urchin Contig 29068@(((:tag . "NNP") (:stem . "RAG1-Like") (:form . "RAG1-Like") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Protein") (:form . "Protein") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "NN") (:stem . "sp_29068") (:form . "SP_29068") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Sea") (:form . "Sea") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Urchin") (:form . "Urchin") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "Contig") (:form . "Contig") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "CD") (:stem . "29068") (:form . "29068") (:end . 57) (:start . 52)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s6.365) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102105@unknown@formal@none@1@S@(A) Exon/intron structure of the SP_29068 gene is reported based on the FGENESH prediction.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "Exon/intron") (:form . "Exon/intron") (:end . 15)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "sp_29068") (:form . "SP_29068") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "VBN") (:stem . "base") (:form . "based") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 55))\n ((:tag . "NN") (:stem . "fgenesh") (:form . "FGENESH") (:end . 79)\n  (:start . 72) (:id . 56))\n ((:tag . "NN") (:stem . "prediction") (:form . "prediction") (:end . 90)\n  (:start . 80) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s6.366) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102106@unknown@formal@none@1@S@(B) Alignment of the predicted protein and human RAG1 (29% identity, E = 10-43.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "Alignment") (:form . "Alignment") (:end . 13)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "predict") (:form . "predicted") (:end . 30)\n  (:start . 21) (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 48) (:start . 43)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 53))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 58) (:start . 57)\n  (:id . 55))\n ((:tag . "NN") (:stem . "identity") (:form . "identity") (:end . 67)\n  (:start . 59) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 70) (:start . 69)\n  (:id . 58))\n ((:tag . "SYM") (:stem . "=") (:form . "=") (:end . 72) (:start . 71)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10-43") (:form . "10-43") (:end . 78) (:start . 73)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s6.367) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102107@unknown@formal@none@1@S@The intron in SP_29068 is inserted between residues shaded in green and red.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "sp_29068") (:form . "SP_29068") (:end . 22)\n  (:start . 14) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "shade") (:form . "shaded") (:end . 58)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "red") (:form . "red") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s6.368) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102108@unknown@formal@none@1@S@Gly460 that harbors the intron in the teleost RAG1 is shaded in black.@(((:tag . "NNP") (:stem . "Gly460") (:form . "Gly460") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "harbor") (:form . "harbors") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NN") (:stem . "intron") (:form . "intron") (:end . 30)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "teleost") (:form . "teleost") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "rag1") (:form . "RAG1") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "shade") (:form . "shaded") (:end . 60)\n  (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "black") (:form . "black") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 70) (:start . 69)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s6.369) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102110@unknown@formal@none@1@S@Non-gapped alignment of consensus sequences of 5? termini of transposons from 22 different families is shown beneath the RSS23 consensus sequence, composed of the RSS heptamer and nonamer.@(((:tag . "JJ") (:stem . "non-gapped") (:form . "Non-gapped") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 20)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 47))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 48) (:start . 47)\n  (:id . 48))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 57)\n  (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "NNS") (:stem . "family") (:form . "families") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "beneath") (:form . "beneath") (:end . 116)\n  (:start . 109) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rss23") (:form . "RSS23") (:end . 126)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 136)\n  (:start . 127) (:id . 62))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 145)\n  (:start . 137) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 146) (:start . 145)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 162) (:start . 159)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rss") (:form . "RSS") (:end . 166) (:start . 163)\n  (:id . 68))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 175)\n  (:start . 167) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 70))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 187)\n  (:start . 180) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s6.371) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102111@unknown@formal@none@1@S@The most conserved nucleotides in the heptamer and nonamer, which are necessary for efficient V(D)J recombination, are highlighted.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NN") (:stem . "nonamer") (:form . "nonamer") (:end . 58)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "NNP") (:stem . "V(D)J") (:form . "V(D)J") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 113) (:start . 100) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "highlight") (:form . "highlighted") (:end . 130)\n  (:start . 119) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s6.372) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102112@unknown@formal@none@1@S@Among the necessary RSS nucleotides, only one, marked by a + corresponds to a nucleotide that is 100% conserved in hAT transposons.@(((:tag . "IN") (:stem . "among") (:form . "Among") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "nucleotide") (:form . "nucleotides") (:end . 35)\n  (:start . 24) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "mark") (:form . "marked") (:end . 53) (:start . 47)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "SYM") (:stem . "+") (:form . "+") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 72)\n  (:start . 61) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 88)\n  (:start . 78) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 96) (:start . 94)\n  (:id . 60))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 100) (:start . 97)\n  (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 101) (:start . 100)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 111)\n  (:start . 102) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 118) (:start . 115)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 130)\n  (:start . 119) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 131) (:start . 130)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s6.373) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102113@unknown@formal@none@1@S@The critical third nucleotide of the hAT 5? termini is always G, as opposed to C in the RSS heptamer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "nucleotide") (:form . "nucleotide") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 51)\n  (:start . 44) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "always") (:form . "always") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "oppose") (:form . "opposed") (:end . 75)\n  (:start . 68) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RSS") (:form . "RSS") (:end . 91) (:start . 88)\n  (:id . 62))\n ((:tag . "NN") (:stem . "heptamer") (:form . "heptamer") (:end . 100)\n  (:start . 92) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s6.374) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102114@unknown@formal@none@1@S@It is also clear from the alignment that the hAT termini do not have any second conserved block, which is expected to be preserved if RSSs have evolved from hAT termini.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 10) (:start . 6)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "alignment") (:form . "alignment") (:end . 35)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 56)\n  (:start . 49) (:id . 52))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 59) (:start . 57)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 72) (:start . 69)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 79)\n  (:start . 73) (:id . 57))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 89)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 95) (:start . 90)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 102)\n  (:start . 97) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 105) (:start . 103)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "expect") (:form . "expected") (:end . 114)\n  (:start . 106) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 120) (:start . 118)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "preserve") (:form . "preserved") (:end . 130)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 133) (:start . 131)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "rss") (:form . "RSSs") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 143) (:start . 139)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "evolve") (:form . "evolved") (:end . 151)\n  (:start . 144) (:id . 70))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 156) (:start . 152)\n  (:id . 71))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 160) (:start . 157)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 168)\n  (:start . 161) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x6.375.1) (:span 106 114)))\n (:ncues ((:id . :x6.375.2) (:span 60 63)))\n (:hscopes ((:id . :x6.375.1) (:span 97 168)))\n (:nscopes ((:id . :x6.375.2) (:span 60 95)))\n (:identifiers (:sid . :s6.375) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102115@unknown@formal@none@1@S@Hobo (GenBank number X04705), Homer (AF110403), Hermes (L34807), Ac9 (K01904), Tam3_AM (X55078), TAG1 (L12220), Pegasus (U47019) are active hAT transposons from fruit fly, Queensland fruit fly, house fly, maize, snapdragon, thale-cress, and African malaria mosquito, respectively.@(((:tag . "NNP") (:stem . "Hobo") (:form . "Hobo") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "x04705") (:form . "X04705") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Homer") (:form . "Homer") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "AF110403") (:form . "AF110403") (:end . 45)\n  (:start . 37) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 46) (:start . 45)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Herme") (:form . "Hermes") (:end . 54)\n  (:start . 48) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "L34807") (:form . "L34807") (:end . 62)\n  (:start . 56) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Ac9") (:form . "Ac9") (:end . 68) (:start . 65)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "K01904") (:form . "K01904") (:end . 76)\n  (:start . 70) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Tam3_AM") (:form . "Tam3_AM") (:end . 86)\n  (:start . 79) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "X55078") (:form . "X55078") (:end . 94)\n  (:start . 88) (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "TAG1") (:form . "TAG1") (:end . 101) (:start . 97)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "L12220") (:form . "L12220") (:end . 109)\n  (:start . 103) (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 110) (:start . 109)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Pegasus") (:form . "Pegasus") (:end . 119)\n  (:start . 112) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 75))\n ((:tag . "NN") (:stem . "u47019") (:form . "U47019") (:end . 127)\n  (:start . 121) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 128) (:start . 127)\n  (:id . 77))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 132) (:start . 129)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 139)\n  (:start . 133) (:id . 79))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 143) (:start . 140)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "transposon") (:form . 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"malaria") (:end . 256)\n  (:start . 249) (:id . 101))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 265)\n  (:start . 257) (:id . 102))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 266) (:start . 265)\n  (:id . 103))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 279)\n  (:start . 267) (:id . 104))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 105)))@@@1@64@((:identifiers (:sid . :s6.376) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102116@unknown@formal@none@1@S@HOPPER_BD is from oriental fruit fly (GenBank AF486809).@(((:tag . "NNP") (:stem . "HOPPER_BD") (:form . "HOPPER_BD") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "oriental") (:form . "oriental") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "AF486809") (:form . "AF486809") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s6.377) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102117@unknown@formal@none@1@S@The consensus sequences of hAT-1N_DP and hAT-1N_DP (nonautonomous transposons from fruit fly, D. pseudoobscura); HAT1N_DR, hAT-2n1_DR, and hAT-N19_DR (nonautonomous transposons from zebrafish); CHARLIE1A and CHESHIRE (human); hAT-N1_SP (sea urchin); ATHAT1, ATHAT7, and ATHAT10 (thale-cress); PegasusA, HATN4_AG, and hAT-2N_AG (African malaria mosquito) were reported in Repbase Update.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 23)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "hAT-1N_DP") (:form . "hAT-1N_DP") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . 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"HATN4_AG") (:end . 311)\n  (:start . 303) (:id . 98))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 312) (:start . 311)\n  (:id . 99))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 316) (:start . 313)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "hAT-2N_AG") (:form . "hAT-2N_AG") (:end . 326)\n  (:start . 317) (:id . 101))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 328) (:start . 327)\n  (:id . 102))\n ((:tag . "JJ") (:stem . "african") (:form . "African") (:end . 335)\n  (:start . 328) (:id . 103))\n ((:tag . "NN") (:stem . "malaria") (:form . "malaria") (:end . 343)\n  (:start . 336) (:id . 104))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 352)\n  (:start . 344) (:id . 105))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 353) (:start . 352)\n  (:id . 106))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 358) (:start . 354)\n  (:id . 107))\n ((:tag . "VBN") (:stem . "report") (:form . 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5102118@unknown@formal@none@1@S@Transib TPase in Eukaryotes@(((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Eukaryote") (:form . "Eukaryotes") (:end . 27)\n  (:start . 17) (:id . 45)))@@@1@4@((:identifiers (:sid . :s6.379) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5102120@unknown@formal@none@1@S@Column 3 shows GenBank sections collecting corresponding sequences: "NR", "WGS", "EST", and "HTGS" are names of GenBank sections; "tr" stands for “Trace Archives.” Column 4 shows a range of E-values of matches between the sea urchin Transib TPase (Transib1_SP) and TPases encoded by the listed species that were detected in TBLASTN searches against corresponding sections of GenBank.@(((:tag . "NN") (:stem . "column") (:form . "Column") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 8) (:start . 7)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "VBG") (:stem . "collect") (:form . "collecting") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . 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5102121@unknown@formal@none@1@S@Matches to the Transib TPase observed for Oryza sativa indica (seven sequences from Trace Archives, 10-48 < E < 10-13) were discarded as a likely sequencing contamination, based on the fact that these sequences were over 80% identical to Hydra magnipapillata traces (the hydra Trace Archive dataset contains over 100 sequences matching the TPase, and hydra Transib TPase sequences are also present in the dbEST section of GenBank).@(((:tag . "NNS") (:stem . "match") (:form . "Matches") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "NNP") (:stem . "TPase") (:form . "TPase") (:end . 28) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "observe") (:form . 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"are") (:end . 384) (:start . 381)\n  (:id . 108))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 389) (:start . 385)\n  (:id . 109))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 397)\n  (:start . 390) (:id . 110))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 400) (:start . 398)\n  (:id . 111))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 404) (:start . 401)\n  (:id . 112))\n ((:tag . "NN") (:stem . "dbest") (:form . "dbEST") (:end . 410)\n  (:start . 405) (:id . 113))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 418)\n  (:start . 411) (:id . 114))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 421) (:start . 419)\n  (:id . 115))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 429)\n  (:start . 422) (:id . 116))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 430) (:start . 429)\n  (:id . 117))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 431) (:start . 430)\n  (:id . 118)))@@@1@77@((:hcues ((:id . :x6.382.1) (:span 139 145)))\n (:hscopes ((:id . :x6.382.1) (:span 139 170)))\n (:identifiers (:sid . :s6.382) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102122@unknown@formal@none@1@S@Analogously, matches to the Transib TPase detected in the AC011430 HTGs and AADC01054609 WGS GenBank sequences, which were annotated as portions of the human genome, were discarded as products of contamination (these sequences contain 100% identical copies of the non-long terminal repeat (LTR) retrotransposon G2_DM [17] from D. melanogaster).@(((:tag . "RB") (:stem . "analogously") (:form . "Analogously") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "match") (:form . "matches") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Transib") (:form . "Transib") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "TPase") (:form . 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"sequences") (:end . 226)\n  (:start . 217) (:id . 78))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 234)\n  (:start . 227) (:id . 79))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 238) (:start . 235)\n  (:id . 80))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 239) (:start . 238)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "identical") (:form . "identical") (:end . 249)\n  (:start . 240) (:id . 82))\n ((:tag . "NNS") (:stem . "copy") (:form . "copies") (:end . 256)\n  (:start . 250) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 259) (:start . 257)\n  (:id . 84))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 263) (:start . 260)\n  (:id . 85))\n ((:tag . "JJ") (:stem . "non-long") (:form . "non-long") (:end . 272)\n  (:start . 264) (:id . 86))\n ((:tag . "JJ") (:stem . "terminal") (:form . "terminal") (:end . 281)\n  (:start . 273) (:id . 87))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 288)\n  (:start . 282) (:id . 88))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 290) (:start . 289)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "LTR") (:form . "LTR") (:end . 293) (:start . 290)\n  (:id . 90))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 294) (:start . 293)\n  (:id . 91))\n ((:tag . "NN") (:stem . "retrotransposon") (:form . "retrotransposon")\n  (:end . 310) (:start . 295) (:id . 92))\n ((:tag . "NNP") (:stem . "G2_DM") (:form . "G2_DM") (:end . 316)\n  (:start . 311) (:id . 93))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 318) (:start . 317)\n  (:id . 94))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 320) (:start . 318)\n  (:id . 95))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 321) (:start . 320)\n  (:id . 96))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 326) (:start . 322)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 329) (:start . 327)\n  (:id . 98))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 342) (:start . 330) (:id . 99))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 343) (:start . 342)\n  (:id . 100))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 344) (:start . 343)\n  (:id . 101)))@@@1@60@((:identifiers (:sid . :s6.383) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102123@unknown@formal@none@1@S@GC Content of Target Sites for hAT Transposons@(((:tag . "NNP") (:stem . "GC") (:form . "GC") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Content") (:form . "Content") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Target") (:form . "Target") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "NNPS") (:stem . "Site") (:form . "Sites") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "transposon") (:form . "Transposons") (:end . 46)\n  (:start . 35) (:id . 49)))@@@1@8@((:identifiers (:sid . :s6.384) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|TableLegend|)))@oe@9-2-2011
5102124@unknown@formal@none@1@S@The table shows that hAT transposons are inserted preferentially into GC-rich sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "table") (:form . "table") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "transposon") (:form . "transposons") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "insert") (:form . "inserted") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "RB") (:stem . "preferentially") (:form . "preferentially")\n  (:end . 64) (:start . 50) (:id . 50))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 69) (:start . 65)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "gc-rich") (:form . "GC-rich") (:end . 77)\n  (:start . 70) (:id . 52))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 83) (:start . 78)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s6.385) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102125@unknown@formal@none@1@S@Each of the 35-bp insertion sites corresponds to two 14-bp and 13-bp DNA fragments flanking a genomic hAT element at its 5? and 3? termini; one of the 8-bp TSDs (flanking the 3? terminus of a transposon) was excluded in each case.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "35-bp") (:form . "35-bp") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "correspond") (:form . "corresponds") (:end . 45)\n  (:start . 34) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "14-bp") (:form . "14-bp") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "13-bp") (:form . "13-bp") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 82)\n  (:start . 73) (:id . 55))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 91)\n  (:start . 83) (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "NN") (:stem . "hat") (:form . "hAT") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 123) (:start . 122)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 65))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "terminus") (:form . "termini") (:end . 138)\n  (:start . 131) (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 139) (:start . 138)\n  (:id . 69))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 143) (:start . 140)\n  (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 146) (:start . 144)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "8-bp") (:form . "8-bp") (:end . 155) (:start . 151)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "tsd") (:form . "TSDs") (:end . 160) (:start . 156)\n  (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 162) (:start . 161)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "flank") (:form . "flanking") (:end . 170)\n  (:start . 162) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 77))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 176) (:start . 175)\n  (:id . 78))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 177) (:start . 176)\n  (:id . 79))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 186)\n  (:start . 178) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 189) (:start . 187)\n  (:id . 81))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 191) (:start . 190)\n  (:id . 82))\n ((:tag . "NN") (:stem . "transposon") (:form . "transposon") (:end . 202)\n  (:start . 192) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 84))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 207) (:start . 204)\n  (:id . 85))\n ((:tag . "VBN") (:stem . "exclude") (:form . "excluded") (:end . 216)\n  (:start . 208) (:id . 86))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 87))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 224) (:start . 220)\n  (:id . 88))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 229) (:start . 225)\n  (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 90)))@@@1@49@((:identifiers (:sid . :s6.386) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102126@unknown@formal@none@1@S@Analogously, the 15-bp insertion sites were composed of two 4-bp and 3-bp flanking fragments.@(((:tag . "RB") (:stem . "analogously") (:form . "Analogously") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "15-bp") (:form . "15-bp") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 52)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "4-bp") (:form . "4-bp") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "3-bp") (:form . "3-bp") (:end . 73) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "flanking") (:form . "flanking") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "NNS") (:stem . "fragment") (:form . "fragments") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s6.387) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102127@unknown@formal@none@1@S@(1) GenBank accession number U47019; (2) Repbase Update, the angrep.ref section; (3) GenBank X04705; (4) Repbase Update, the drorep.ref section; (5) Repbase Update, spurep.ref; (6)Repbase Updates, the zebrep.ref section.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "LS") (:stem . "1") (:form . "1") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 11)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "accession") (:form . "accession") (:end . 21)\n  (:start . 12) (:id . 46))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 28)\n  (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "u47019") (:form . "U47019") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 36) (:start . 35)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 38) (:start . 37)\n  (:id . 50))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 39) (:start . 38)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 40) (:start . 39)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Repbase") (:form . "Repbase") (:end . 48)\n  (:start . 41) (:id . 53))\n ((:tag . "NNP") (:stem . "Update") (:form . "Update") (:end . 55)\n  (:start . 49) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 56))\n ((:tag . "NN") (:stem . "angrep.ref") (:form . "angrep.ref") (:end . 71)\n  (:start . 61) (:id . 57))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 79)\n  (:start . 72) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 80) (:start . 79)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 60))\n ((:tag . "LS") (:stem . "3") (:form . "3") (:end . 83) (:start . 82)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "GenBank") (:form . "GenBank") (:end . 92)\n  (:start . 85) (:id . 63))\n ((:tag . "NN") (:stem . "x04705") (:form . "X04705") (:end . 99)\n  (:start . 93) (:id . 64))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 100) (:start . 99)\n  (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 102) (:start . 101)\n  (:id . 66))\n ((:tag . "LS") (:stem . "4") (:form . "4") (:end . 103) (:start . 102)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Repbase") (:form . "Repbase") (:end . 112)\n  (:start . 105) (:id . 69))\n ((:tag . "NNP") (:stem . "Update") (:form . "Update") (:end . 119)\n  (:start . 113) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 72))\n ((:tag . "NN") (:stem . "drorep.ref") (:form . "drorep.ref") (:end . 135)\n  (:start . 125) (:id . 73))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 143)\n  (:start . 136) (:id . 74))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 144) (:start . 143)\n  (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 76))\n ((:tag . "LS") (:stem . "5") (:form . "5") (:end . 147) (:start . 146)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Repbase") (:form . "Repbase") (:end . 156)\n  (:start . 149) (:id . 79))\n ((:tag . "NNP") (:stem . "Update") (:form . "Update") (:end . 163)\n  (:start . 157) (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 81))\n ((:tag . "NN") (:stem . "spurep.ref") (:form . "spurep.ref") (:end . 175)\n  (:start . 165) (:id . 82))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 176) (:start . 175)\n  (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 178) (:start . 177)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "6)Repbase") (:form . "6)Repbase") (:end . 187)\n  (:start . 178) (:id . 85))\n ((:tag . "NNP") (:stem . "Update") (:form . "Updates") (:end . 195)\n  (:start . 188) (:id . 86))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 200) (:start . 197)\n  (:id . 88))\n ((:tag . "NN") (:stem . "zebrep.ref") (:form . "zebrep.ref") (:end . 211)\n  (:start . 201) (:id . 89))\n ((:tag . "NN") (:stem . "section") (:form . "section") (:end . 219)\n  (:start . 212) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 91)))@@@1@50@((:identifiers (:sid . :s6.388) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102128@unknown@formal@none@1@S@Copies of Pegasus, HATN4_AG, and HAT2N_AG were identified in the mosquito A. gambiae genome; Hobo and hAT-1N_DP in the D. melanogaster and D. pseudoobscura fruit fly genomes, respectively; HAT-1N_SP in the sea urchin genome; and HAT1N_DR, HAT-2N1_DR, and HAT-N19_DR in the zebrafish genome.@(((:tag . "NNS") (:stem . "copy") (:form . "Copies") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Pegasus") (:form . "Pegasus") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "HATN4_AG") (:form . "HATN4_AG") (:end . 27)\n  (:start . 19) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "HAT2N_AG") (:form . "HAT2N_AG") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mosquito") (:form . "mosquito") (:end . 73)\n  (:start . 65) (:id . 54))\n ((:tag . "NN") (:stem . "a.") (:form . "A.") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "gambiae") (:form . "gambiae") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Hobo") (:form . "Hobo") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "hAT-1N_DP") (:form . "hAT-1N_DP") (:end . 111)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 118) (:start . 115)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 134) (:start . 122) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "D.") (:form . "D.") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pseudoobscura") (:form . "pseudoobscura")\n  (:end . 155) (:start . 142) (:id . 68))\n ((:tag . "NN") (:stem . "fruit") (:form . "fruit") (:end . 161)\n  (:start . 156) (:id . 69))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 165) (:start . 162)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 173)\n  (:start . 166) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 187)\n  (:start . 175) (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "HAT-1N_SP") (:form . "HAT-1N_SP") (:end . 198)\n  (:start . 189) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 205) (:start . 202)\n  (:id . 77))\n ((:tag . "NN") (:stem . "sea") (:form . "sea") (:end . 209) (:start . 206)\n  (:id . 78))\n ((:tag . "NN") (:stem . "urchin") (:form . "urchin") (:end . 216)\n  (:start . 210) (:id . 79))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 223)\n  (:start . 217) (:id . 80))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 224) (:start . 223)\n  (:id . 81))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 228) (:start . 225)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "HAT1N_DR") (:form . "HAT1N_DR") (:end . 237)\n  (:start . 229) (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 238) (:start . 237)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "HAT-2N1_DR") (:form . "HAT-2N1_DR") (:end . 249)\n  (:start . 239) (:id . 85))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 250) (:start . 249)\n  (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 254) (:start . 251)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "HAT-N19_DR") (:form . "HAT-N19_DR") (:end . 265)\n  (:start . 255) (:id . 88))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 268) (:start . 266)\n  (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 272) (:start . 269)\n  (:id . 90))\n ((:tag . "NN") (:stem . "zebrafish") (:form . "zebrafish") (:end . 282)\n  (:start . 273) (:id . 91))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 289)\n  (:start . 283) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s6.389) (:did . :pmc1131882) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102130@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s7.2) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102131@unknown@formal@none@1@S@Adenosine deaminase (ADA) is an enzyme present in all organisms that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine.@(((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "deaminase") (:form . "deaminase") (:end . 19)\n  (:start . 10) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 38)\n  (:start . 32) (:id . 49))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 53) (:start . 50)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 63)\n  (:start . 54) (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "catalyze") (:form . "catalyzes") (:end . 78)\n  (:start . 69) (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "irreversible") (:form . "irreversible") (:end . 95)\n  (:start . 83) (:id . 57))\n ((:tag . "NN") (:stem . "deamination") (:form . "deamination") (:end . 107)\n  (:start . 96) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 139) (:start . 125) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "inosine") (:form . "inosine") (:end . 150)\n  (:start . 143) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 65))\n ((:tag . "NN") (:stem . "deoxyinosine") (:form . "deoxyinosine") (:end . 167)\n  (:start . 155) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s7.3) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102132@unknown@formal@none@1@S@Both adenosine and deoxyadenosine are biologically active purines that can have a deep impact on cellular physiology; notably, ADA deficiency in humans causes severe combined immunodeficiency.@(((:tag . "CC") (:stem . "both") (:form . "Both") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 33) (:start . 19) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 46))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 50)\n  (:start . 38) (:id . 47))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 57)\n  (:start . 51) (:id . 48))\n ((:tag . "NNS") (:stem . "purine") (:form . "purines") (:end . 65)\n  (:start . 58) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 70) (:start . 66)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 74) (:start . 71)\n  (:id . 51))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 79) (:start . 75)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 81) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "deep") (:form . "deep") (:end . 86) (:start . 82)\n  (:id . 54))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 93)\n  (:start . 87) (:id . 55))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 105)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "physiology") (:form . "physiology") (:end . 116)\n  (:start . 106) (:id . 58))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "RB") (:stem . "notably") (:form . "notably") (:end . 125)\n  (:start . 118) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 141)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 151)\n  (:start . 145) (:id . 65))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 158)\n  (:start . 152) (:id . 66))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 165)\n  (:start . 159) (:id . 67))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 174)\n  (:start . 166) (:id . 68))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 191) (:start . 175) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s7.4) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102133@unknown@formal@none@1@S@We have established a Drosophila model to study the effects of altered adenosine levels in vivo by genetic elimination of adenosine deaminase-related growth factor-A (ADGF-A), which has ADA activity and is expressed in the gut and hematopoietic organ.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 21) (:start . 20)\n  (:id . 45))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 80)\n  (:start . 71) (:id . 54))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 87)\n  (:start . 81) (:id . 55))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 118)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . "JJ") (:stem . "deaminase-related") (:form . "deaminase-related")\n  (:end . 149) (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 156)\n  (:start . 150) (:id . 64))\n ((:tag . "NNP") (:stem . "factor-A") (:form . "factor-A") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 167) (:start . 166)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 181)\n  (:start . 176) (:id . 70))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 185) (:start . 182)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 189) (:start . 186)\n  (:id . 72))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 198)\n  (:start . 190) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 202) (:start . 199)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 205) (:start . 203)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 215)\n  (:start . 206) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . "NN") (:stem . "gut") (:form . "gut") (:end . 226) (:start . 223)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 230) (:start . 227)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 244) (:start . 231) (:id . 81))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 250)\n  (:start . 245) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 251) (:start . 250)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s7.5) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102134@unknown@formal@none@1@S@Here we show that the hemocytes (blood cells) are the main regulator of adenosine in the Drosophila larva, as was speculated previously for mammals.@(((:tag . "RB") (:stem . "here") (:form . "Here") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 38) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 58) (:start . 54)\n  (:id . 54))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 68)\n  (:start . 59) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 81)\n  (:start . 72) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 99)\n  (:start . 89) (:id . 60))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 113) (:start . 110)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "speculate") (:form . "speculated") (:end . 124)\n  (:start . 114) (:id . 65))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 135)\n  (:start . 125) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.6) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102135@unknown@formal@none@1@S@The elevated level of adenosine in the hemolymph due to lack of ADGF-A leads to apparently inconsistent phenotypic effects: precocious metamorphic changes including differentiation of macrophage-like cells and fat body disintegration on one hand, and delay of development with block of pupariation on the other.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 31)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . 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"inconsistent") (:end . 103)\n  (:start . 91) (:id . 58))\n ((:tag . "JJ") (:stem . "phenotypic") (:form . "phenotypic") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 122)\n  (:start . 115) (:id . 60))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 134)\n  (:start . 124) (:id . 62))\n ((:tag . "JJ") (:stem . "metamorphic") (:form . "metamorphic") (:end . 146)\n  (:start . 135) (:id . 63))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 164)\n  (:start . 155) (:id . 65))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 180) (:start . 165) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 199) (:start . 184) (:id . 68))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 205)\n  (:start . 200) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 213) (:start . 210)\n  (:id . 71))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 218) (:start . 214)\n  (:id . 72))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 233) (:start . 219) (:id . 73))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 236) (:start . 234)\n  (:id . 74))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 240) (:start . 237)\n  (:id . 75))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 245) (:start . 241)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 246) (:start . 245)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 250) (:start . 247)\n  (:id . 78))\n ((:tag . "NN") (:stem . "delay") (:form . "delay") (:end . 256)\n  (:start . 251) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 259) (:start . 257)\n  (:id . 80))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 271)\n  (:start . 260) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 276) (:start . 272)\n  (:id . 82))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 282)\n  (:start . 277) (:id . 83))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 285) (:start . 283)\n  (:id . 84))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 297)\n  (:start . 286) (:id . 85))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 300) (:start . 298)\n  (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 304) (:start . 301)\n  (:id . 87))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 310)\n  (:start . 305) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 311) (:start . 310)\n  (:id . 89)))@@@1@48@((:hcues ((:id . :x7.7.1) (:span 80 90)))\n (:ncues ((:id . :x7.7.2) (:span 56 60)))\n (:hscopes ((:id . :x7.7.1) (:span 80 122)))\n (:nscopes ((:id . :x7.7.2) (:span 56 70)))\n (:identifiers (:sid . :s7.7) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102136@unknown@formal@none@1@S@The block of pupariation appears to involve signaling through the adenosine receptor (AdoR), but fat body disintegration, which is promoted by action of the hemocytes, seems to be independent of the AdoR.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 53)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "AdoR") (:form . "AdoR") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 120) (:start . 106) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 127)\n  (:start . 122) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 139)\n  (:start . 131) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 149)\n  (:start . 143) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 166)\n  (:start . 157) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 173)\n  (:start . 168) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 176) (:start . 174)\n  (:id . 73))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 179) (:start . 177)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 191)\n  (:start . 180) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 77))\n ((:tag . "NN") (:stem . "ador") (:form . "AdoR") (:end . 203) (:start . 199)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 204) (:start . 203)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x7.8.1) (:span 168 173)) ((:id . :x7.8.2) (:span 25 32)))\n (:hscopes ((:id . :x7.8.1) (:span 97 203)) ((:id . :x7.8.2) (:span 0 91)))\n (:identifiers (:sid . :s7.8) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102137@unknown@formal@none@1@S@The existence of such an independent mechanism has also been suggested in mammals.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 36)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 46)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 70)\n  (:start . 61) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 81)\n  (:start . 74) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x7.9.1) (:span 61 70)))\n (:hscopes ((:id . :x7.9.1) (:span 0 81)))\n (:identifiers (:sid . :s7.9) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102138@unknown@formal@none@1@S@Introduction@(((:tag . "NN") (:stem . "introduction") (:form . "Introduction") (:end . 12)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s7.10) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102140@unknown@formal@none@1@S@It is a critically important enzyme for human survival because its congenital absence causes severe combined immunodeficiency disease (SCID).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 7) (:start . 6)\n  (:id . 44))\n ((:tag . "RB") (:stem . "critically") (:form . "critically") (:end . 18)\n  (:start . 8) (:id . 45))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "congenital") (:form . "congenital") (:end . 77)\n  (:start . 67) (:id . 53))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "JJ") (:stem . "combined") (:form . "combined") (:end . 108)\n  (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "immunodeficiency") (:form . "immunodeficiency")\n  (:end . 125) (:start . 109) (:id . 58))\n ((:tag . "NN") (:stem . "disease") (:form . "disease") (:end . 133)\n  (:start . 126) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "SCID") (:form . "SCID") (:end . 139) (:start . 135)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.12) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102141@unknown@formal@none@1@S@ADA deficiency accounts for about 20% of all types of SCID [1].@(((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "account") (:form . "accounts") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 44) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "SCID") (:form . "SCID") (:end . 58) (:start . 54)\n  (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 60) (:start . 59)\n  (:id . 54))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 61) (:start . 60)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 62) (:start . 61)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 63) (:start . 62)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s7.13) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102142@unknown@formal@none@1@S@It is one of the most severe human immunodeficiencies and is associated with depletion of all three major categories of lymphocytes: T cells, B cells, and natural killer cells, resulting in impaired cellular immunity and decreased production of immunoglobulins [2].@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 46))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 21) (:start . 17)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 28)\n  (:start . 22) (:id . 48))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 34) (:start . 29)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "immunodeficiency") (:form . "immunodeficiencies")\n  (:end . 53) (:start . 35) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 71)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "depletion") (:form . "depletion") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NNS") (:stem . "category") (:form . "categories") (:end . 116)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lymphocyte") (:form . "lymphocytes") (:end . 131)\n  (:start . 120) (:id . 62))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "NN") (:stem . "t") (:form . "T") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 140)\n  (:start . 135) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 149)\n  (:start . 144) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "natural") (:form . "natural") (:end . 162)\n  (:start . 155) (:id . 71))\n ((:tag . "NN") (:stem . "killer") (:form . "killer") (:end . 169)\n  (:start . 163) (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 175)\n  (:start . 170) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 176) (:start . 175)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 186)\n  (:start . 177) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 189) (:start . 187)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "impaired") (:form . "impaired") (:end . 198)\n  (:start . 190) (:id . 77))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 207)\n  (:start . 199) (:id . 78))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 216)\n  (:start . 208) (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 220) (:start . 217)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 230)\n  (:start . 221) (:id . 81))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 241)\n  (:start . 231) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 244) (:start . 242)\n  (:id . 83))\n ((:tag . "NNS") (:stem . "immunoglobulin") (:form . "immunoglobulins")\n  (:end . 260) (:start . 245) (:id . 84))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 262) (:start . 261)\n  (:id . 85))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 263) (:start . 262)\n  (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 264) (:start . 263)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s7.14) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102143@unknown@formal@none@1@S@Without intervention, the affected individuals die from opportunistic infections within the first few months of life.@(((:tag . "IN") (:stem . "without") (:form . "Without") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "intervention") (:form . "intervention") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "affected") (:form . "affected") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 46)\n  (:start . 35) (:id . 47))\n ((:tag . "VBP") (:stem . "die") (:form . "die") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "opportunistic") (:form . "opportunistic")\n  (:end . 69) (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "infection") (:form . "infections") (:end . 80)\n  (:start . 70) (:id . 51))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 87)\n  (:start . 81) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 97) (:start . 92)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "month") (:form . "months") (:end . 108)\n  (:start . 102) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "NN") (:stem . "life") (:form . "life") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:ncues ((:id . :x7.15.1) (:span 0 7)))\n (:nscopes ((:id . :x7.15.1) (:span 0 20)))\n (:identifiers (:sid . :s7.15) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102144@unknown@formal@none@1@S@ADA occurs as a soluble monomer in all human cells, but also exists as “ecto-ADA,” bound to the membrane glycoprotein CD26/dipeptidyl peptidase IV, and it has been suggested that this form of ADA regulates extracellular adenosine levels [3].@(((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "monomer") (:form . "monomer") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 38) (:start . 35)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 44) (:start . 39)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 50) (:start . 45)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 55) (:start . 52)\n  (:id . 53))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 60) (:start . 56)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "exist") (:form . "exists") (:end . 67)\n  (:start . 61) (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 72) (:start . 71)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ecto-ADA") (:form . "ecto-ADA") (:end . 80)\n  (:start . 72) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 59))\n ((:tag . "NN") (:stem . "”") (:form . "”") (:end . 82) (:start . 81)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "bind") (:form . "bound") (:end . 88) (:start . 83)\n  (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 63))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 104)\n  (:start . 96) (:id . 64))\n ((:tag . "NN") (:stem . "glycoprotein") (:form . "glycoprotein") (:end . 117)\n  (:start . 105) (:id . 65))\n ((:tag . "NNP") (:stem . "CD26/dipeptidyl") (:form . "CD26/dipeptidyl")\n  (:end . 133) (:start . 118) (:id . 66))\n ((:tag . "NN") (:stem . "peptidase") (:form . "peptidase") (:end . 143)\n  (:start . 134) (:id . 67))\n ((:tag . "CD") (:stem . "iv") (:form . "IV") (:end . 146) (:start . 144)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 151) (:start . 148)\n  (:id . 70))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 154) (:start . 152)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 158) (:start . 155)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 163) (:start . 159)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 173)\n  (:start . 164) (:id . 74))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 178) (:start . 174)\n  (:id . 75))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 183) (:start . 179)\n  (:id . 76))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 188) (:start . 184)\n  (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 195) (:start . 192)\n  (:id . 79))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 205)\n  (:start . 196) (:id . 80))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 219) (:start . 206) (:id . 81))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 229)\n  (:start . 220) (:id . 82))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 236)\n  (:start . 230) (:id . 83))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 238) (:start . 237)\n  (:id . 84))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 239) (:start . 238)\n  (:id . 85))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 240) (:start . 239)\n  (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x7.16.1) (:span 164 173)))\n (:hscopes ((:id . :x7.16.1) (:span 164 236)))\n (:identifiers (:sid . :s7.16) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102145@unknown@formal@none@1@S@ADA deficiency is accompanied by greatly elevated levels of the ADA substrates adenosine and deoxyadenosine, both of which are biologically active purines that can have a deep impact on cellular physiology.@(((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 107) (:start . 93) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 57))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 113) (:start . 109)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 122)\n  (:start . 117) (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 61))\n ((:tag . "RB") (:stem . "biologically") (:form . "biologically") (:end . 139)\n  (:start . 127) (:id . 62))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . "NNS") (:stem . "purine") (:form . "purines") (:end . 154)\n  (:start . 147) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 159) (:start . 155)\n  (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 163) (:start . 160)\n  (:id . 66))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 168) (:start . 164)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 170) (:start . 169)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "deep") (:form . "deep") (:end . 175) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "impact") (:form . "impact") (:end . 182)\n  (:start . 176) (:id . 70))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "physiology") (:form . "physiology") (:end . 205)\n  (:start . 195) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 206) (:start . 205)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.17) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102146@unknown@formal@none@1@S@Adenosine is not just a metabolite; it is also a signaling molecule that regulates numerous cellular functions by binding to G protein-coupled adenosine receptors (A1, A2a, A2b, and A3 in mammals) that can regulate intracellular cyclic adenosine monophosphate [4].@(((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 34)\n  (:start . 24) (:id . 47))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 46) (:start . 42)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 58)\n  (:start . 49) (:id . 53))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 72) (:start . 68)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 82)\n  (:start . 73) (:id . 56))\n ((:tag . "JJ") (:stem . "numerous") (:form . "numerous") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 110)\n  (:start . 101) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "protein-coupled") (:form . "protein-coupled")\n  (:end . 142) (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "NNS") (:stem . "receptor") (:form . "receptors") (:end . 162)\n  (:start . 153) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 164) (:start . 163)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "A1") (:form . "A1") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 167) (:start . 166)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "A2a") (:form . "A2a") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "A2b") (:form . "A2b") (:end . 176) (:start . 173)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 177) (:start . 176)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "NN") (:stem . "a3") (:form . "A3") (:end . 184) (:start . 182)\n  (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 187) (:start . 185)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 195)\n  (:start . 188) (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 78))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 201) (:start . 197)\n  (:id . 79))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 205) (:start . 202)\n  (:id . 80))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 214)\n  (:start . 206) (:id . 81))\n ((:tag . "JJ") (:stem . "intracellular") (:form . "intracellular")\n  (:end . 228) (:start . 215) (:id . 82))\n ((:tag . "JJ") (:stem . "cyclic") (:form . "cyclic") (:end . 235)\n  (:start . 229) (:id . 83))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 245)\n  (:start . 236) (:id . 84))\n ((:tag . "NN") (:stem . "monophosphate") (:form . "monophosphate")\n  (:end . 259) (:start . 246) (:id . 85))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 261) (:start . 260)\n  (:id . 86))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 262) (:start . 261)\n  (:id . 87))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 263) (:start . 262)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s7.18) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102147@unknown@formal@none@1@S@Deoxyadenosine is a cytotoxic metabolite released by various cell populations that undergo programmed cell death; it can kill cells through a mechanism that includes disturbances in deoxynucleotide metabolism [5].@(((:tag . "NNP") (:stem . "Deoxyadenosine") (:form . "Deoxyadenosine")\n  (:end . 14) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 19) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "cytotoxic") (:form . "cytotoxic") (:end . 29)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "metabolite") (:form . "metabolite") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "population") (:form . "populations") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "undergo") (:form . "undergo") (:end . 90)\n  (:start . 83) (:id . 53))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 101)\n  (:start . 91) (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 106) (:start . 102)\n  (:id . 55))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 112)\n  (:start . 107) (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 113) (:start . 112)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 116) (:start . 114)\n  (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "VB") (:stem . "kill") (:form . "kill") (:end . 125) (:start . 121)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 139)\n  (:start . 132) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 151)\n  (:start . 142) (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 165)\n  (:start . 157) (:id . 66))\n ((:tag . "NNS") (:stem . "disturbance") (:form . "disturbances") (:end . 178)\n  (:start . 166) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "deoxynucleotide") (:form . "deoxynucleotide")\n  (:end . 197) (:start . 182) (:id . 69))\n ((:tag . "NN") (:stem . "metabolism") (:form . "metabolism") (:end . 208)\n  (:start . 198) (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 210) (:start . 209)\n  (:id . 71))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 211) (:start . 210)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 212) (:start . 211)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.19) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102148@unknown@formal@none@1@S@Extracellular adenosine is now considered an important stress hormone that is released in excessive amounts in the vicinity of immune cells during both systemic and cellular stress [6].@(((:tag . "JJ") (:stem . "extracellular") (:form . "Extracellular")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 23)\n  (:start . 14) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 26) (:start . 24)\n  (:id . 44))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 30) (:start . 27)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "consider") (:form . "considered") (:end . 41)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 44) (:start . 42)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 69)\n  (:start . 62) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 86)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "excessive") (:form . "excessive") (:end . 99)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "amount") (:form . "amounts") (:end . 107)\n  (:start . 100) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "NN") (:stem . "vicinity") (:form . "vicinity") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 133)\n  (:start . 127) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 151) (:start . 147)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 160)\n  (:start . 152) (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 164) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 173)\n  (:start . 165) (:id . 67))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 180)\n  (:start . 174) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 182) (:start . 181)\n  (:id . 69))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 183) (:start . 182)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 185) (:start . 184)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.20) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102150@unknown@formal@none@1@S@Specific inflammatory stimuli such as bacterial products are also capable of triggering adenosine release from immune cells [8].@(((:tag . "JJ") (:stem . "specific") (:form . "Specific") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 21)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 34) (:start . 30)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 37) (:start . 35)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "bacterial") (:form . "bacterial") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 56)\n  (:start . 48) (:id . 48))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 60) (:start . 57)\n  (:id . 49))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 65) (:start . 61)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "trigger") (:form . "triggering") (:end . 87)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 97)\n  (:start . 88) (:id . 54))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 105)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 110) (:start . 106)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "immune") (:form . "immune") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 123)\n  (:start . 118) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 125) (:start . 124)\n  (:id . 59))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 126) (:start . 125)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s7.22) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102151@unknown@formal@none@1@S@These data are in line with evidence demonstrating a dramatic increase in extracellular adenosine levels under conditions associated with multiple organ failure, which is the cause of 50%–80% of all deaths in surgical intensive care units [6].@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 36)\n  (:start . 28) (:id . 48))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 50)\n  (:start . 37) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "dramatic") (:form . "dramatic") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 87) (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 97)\n  (:start . 88) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 104)\n  (:start . 98) (:id . 56))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 121)\n  (:start . 111) (:id . 58))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 132)\n  (:start . 122) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 137) (:start . 133)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 146)\n  (:start . 138) (:id . 61))\n ((:tag . "NN") (:stem . "organ") (:form . "organ") (:end . 152)\n  (:start . 147) (:id . 62))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 160)\n  (:start . 153) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 167)\n  (:start . 162) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 170) (:start . 168)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cause") (:form . "cause") (:end . 180)\n  (:start . 175) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 183) (:start . 181)\n  (:id . 69))\n ((:tag . "CD") (:stem . "50%–80") (:form . "50%–80") (:end . 190)\n  (:start . 184) (:id . 70))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 191) (:start . 190)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 194) (:start . 192)\n  (:id . 72))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "death") (:form . "deaths") (:end . 205)\n  (:start . 199) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 208) (:start . 206)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "surgical") (:form . "surgical") (:end . 217)\n  (:start . 209) (:id . 76))\n ((:tag . "JJ") (:stem . "intensive") (:form . "intensive") (:end . 227)\n  (:start . 218) (:id . 77))\n ((:tag . "NN") (:stem . "care") (:form . "care") (:end . 232) (:start . 228)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "unit") (:form . "units") (:end . 238)\n  (:start . 233) (:id . 79))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 240) (:start . 239)\n  (:id . 80))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 241) (:start . 240)\n  (:id . 81))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 242) (:start . 241)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s7.23) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102152@unknown@formal@none@1@S@ADA is not the only adenosine deaminase in mammalian cells.@(((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 19) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 29)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "deaminase") (:form . "deaminase") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 52)))@@@1@11@((:ncues ((:id . :x7.24.1) (:span 7 10)))\n (:nscopes ((:id . :x7.24.1) (:span 7 58)))\n (:identifiers (:sid . :s7.24) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102153@unknown@formal@none@1@S@Recently, the cat eye syndrome critical region protein 1 (CECR1) gene was identified and shown to encode a protein representing a subfamily of proteins related to but distinct from classical ADAs [9].@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cat") (:form . "cat") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "eye") (:form . "eye") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "critical") (:form . "critical") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cecr1") (:form . "CECR1") (:end . 63) (:start . 58)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 84)\n  (:start . 74) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "VB") (:stem . "encode") (:form . "encode") (:end . 104)\n  (:start . 98) (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 114)\n  (:start . 107) (:id . 63))\n ((:tag . "VBG") (:stem . "represent") (:form . "representing") (:end . 127)\n  (:start . 115) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 65))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 139)\n  (:start . 130) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 151)\n  (:start . 143) (:id . 68))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 159)\n  (:start . 152) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 166) (:start . 163)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 175)\n  (:start . 167) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 180) (:start . 176)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "classical") (:form . "classical") (:end . 190)\n  (:start . 181) (:id . 74))\n ((:tag . "NNS") (:stem . "ada") (:form . "ADAs") (:end . 195) (:start . 191)\n  (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 197) (:start . 196)\n  (:id . 76))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 198) (:start . 197)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 199) (:start . 198)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s7.25) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102154@unknown@formal@none@1@S@The duplication of a small region of chromosome 22 containing this gene is associated with “cat eye syndrome,” a disorder characterized by hypoplastic kidneys, congenital heart malformation, and anomalous pulmonary venous connections.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "duplication") (:form . "duplication") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cat") (:form . "cat") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "eye") (:form . "eye") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "NN") (:stem . "syndrome") (:form . "syndrome") (:end . 108)\n  (:start . 100) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "”") (:form . "”") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 112) (:start . 111)\n  (:id . 63))\n ((:tag . "NN") (:stem . "disorder") (:form . "disorder") (:end . 121)\n  (:start . 113) (:id . 64))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 135) (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "hypoplastic") (:form . "hypoplastic") (:end . 150)\n  (:start . 139) (:id . 67))\n ((:tag . "NNS") (:stem . "kidney") (:form . "kidneys") (:end . 158)\n  (:start . 151) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 159) (:start . 158)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "congenital") (:form . "congenital") (:end . 170)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "heart") (:form . "heart") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "NN") (:stem . "malformation") (:form . "malformation") (:end . 189)\n  (:start . 177) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 190) (:start . 189)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 194) (:start . 191)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "anomalous") (:form . "anomalous") (:end . 204)\n  (:start . 195) (:id . 75))\n ((:tag . "JJ") (:stem . "pulmonary") (:form . "pulmonary") (:end . 214)\n  (:start . 205) (:id . 76))\n ((:tag . "JJ") (:stem . "venous") (:form . "venous") (:end . 221)\n  (:start . 215) (:id . 77))\n ((:tag . "NNS") (:stem . "connection") (:form . "connections") (:end . 233)\n  (:start . 222) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s7.26) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102155@unknown@formal@none@1@S@The founding member of this subfamily is encoded by insect-derived growth factor(IDGF) [10], and homologs have been described in various organisms [11–14].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "found") (:form . "founding") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "insect-derived") (:form . "insect-derived")\n  (:end . 66) (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 73)\n  (:start . 67) (:id . 52))\n ((:tag . "NNS") (:stem . "factor(IDGF)") (:form . "factor(IDGF)") (:end . 86)\n  (:start . 74) (:id . 53))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 96) (:start . 93)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 105)\n  (:start . 97) (:id . 59))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 115) (:start . 111)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 125)\n  (:start . 116) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 136)\n  (:start . 129) (:id . 64))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 146)\n  (:start . 137) (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 148) (:start . 147)\n  (:id . 66))\n ((:tag . "CD") (:stem . "11–14") (:form . "11–14") (:end . 153)\n  (:start . 148) (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 154) (:start . 153)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.27) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102156@unknown@formal@none@1@S@We have previously found six Drosophila genes with sequence similarity to the CECR1 subfamily [15].@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 59)\n  (:start . 51) (:id . 50))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cecr1") (:form . "CECR1") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "subfamily") (:form . "subfamily") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.28) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102157@unknown@formal@none@1@S@Their products are mitogenic on Drosophila cells, and at least two of them (ADGF-A and ADGF-D) exhibit strong ADA activity, which is necessary for their mitogenic function.@(((:tag . "PRP$") (:stem . "their") (:form . "Their") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 66) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 82)\n  (:start . 76) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "ADGF-D") (:form . "ADGF-D") (:end . 93)\n  (:start . 87) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "exhibit") (:form . "exhibit") (:end . 102)\n  (:start . 95) (:id . 61))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 109)\n  (:start . 103) (:id . 62))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 129)\n  (:start . 124) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 142)\n  (:start . 133) (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 146) (:start . 143)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 152)\n  (:start . 147) (:id . 70))\n ((:tag . "JJ") (:stem . "mitogenic") (:form . "mitogenic") (:end . 162)\n  (:start . 153) (:id . 71))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 171)\n  (:start . 163) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s7.29) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102158@unknown@formal@none@1@S@We therefore named them adenosine deaminase-related growth factors (ADGFs).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "name") (:form . "named") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adenosine") (:form . "adenosine") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "JJ") (:stem . "deaminase-related") (:form . "deaminase-related")\n  (:end . 51) (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 58)\n  (:start . 52) (:id . 48))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 66)\n  (:start . 59) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ADGF") (:form . "ADGFs") (:end . 73) (:start . 68)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.30) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102160@unknown@formal@none@1@S@Drosophila also contains a gene, termed Ada, with sequence similarity to human ADA, but as we have previously shown the product of this gene is most likely not an active ADA [16].@(((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 24)\n  (:start . 16) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 39) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Ada") (:form . "Ada") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 69)\n  (:start . 59) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 78) (:start . 73)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 109)\n  (:start . 99) (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 119) (:start . 116)\n  (:id . 64))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 127)\n  (:start . 120) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 135) (:start . 131)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 140) (:start . 136)\n  (:id . 68))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 143) (:start . 141)\n  (:id . 69))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 148) (:start . 144)\n  (:id . 70))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 155)\n  (:start . 149) (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 159) (:start . 156)\n  (:id . 72))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 162) (:start . 160)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 169)\n  (:start . 163) (:id . 74))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 173) (:start . 170)\n  (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 175) (:start . 174)\n  (:id . 76))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 177) (:start . 175)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 178) (:start . 177)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x7.32.2) (:span 149 155)))\n (:ncues ((:id . :x7.32.1) (:span 156 159)))\n (:hscopes ((:id . :x7.32.2) (:span 149 173)))\n (:nscopes ((:id . :x7.32.1) (:span 156 173)))\n (:identifiers (:sid . :s7.32) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102161@unknown@formal@none@1@S@In this report we show that a null mutation in Drosophila ADGF-A gene leads to dramatically increased levels of adenosine and deoxyadenosine in the larval hemolymph.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "report") (:form . "report") (:end . 14) (:start . 8)\n  (:id . 44))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 34) (:start . 30)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 43)\n  (:start . 35) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 51))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 57)\n  (:start . 47) (:id . 52))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 64)\n  (:start . 58) (:id . 53))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 75) (:start . 70)\n  (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 91)\n  (:start . 79) (:id . 57))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 101)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 108)\n  (:start . 102) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 60))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 121)\n  (:start . 112) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 140) (:start . 126) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 154)\n  (:start . 148) (:id . 66))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 164)\n  (:start . 155) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.33) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102162@unknown@formal@none@1@S@This increase leads to larval death associated with the disintegration of fat body and the development of melanotic tumors.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 46)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 70) (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 102)\n  (:start . 91) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 122)\n  (:start . 116) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.34) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102163@unknown@formal@none@1@S@We present a detailed analysis of the hematopoietic defects associated with the adgf-a mutation, show a genetic interaction of this mutation with signaling through the Drosophila adenosine receptor (AdoR, encoded by the gene CG9753) and with regulation of premetamorphic changes by ecdysone, as well as a genetic interaction of ADGF-A with a major innate immunity regulator—the Toll signaling pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "present") (:form . "present") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "detailed") (:form . "detailed") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "hematopoietic") (:form . "hematopoietic")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 59)\n  (:start . 52) (:id . 50))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 70)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 86)\n  (:start . 80) (:id . 54))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 95)\n  (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 96) (:start . 95)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 101) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 123)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 131) (:start . 127)\n  (:id . 62))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 140)\n  (:start . 132) (:id . 63))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 163)\n  (:start . 156) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 67))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 178)\n  (:start . 168) (:id . 68))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 188)\n  (:start . 179) (:id . 69))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 197)\n  (:start . 189) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "AdoR") (:form . "AdoR") (:end . 203) (:start . 199)\n  (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 204) (:start . 203)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 212)\n  (:start . 205) (:id . 74))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 215) (:start . 213)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 224) (:start . 220)\n  (:id . 77))\n ((:tag . "NN") (:stem . "cg9753") (:form . "CG9753") (:end . 231)\n  (:start . 225) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 232) (:start . 231)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 241) (:start . 237)\n  (:id . 81))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 252)\n  (:start . 242) (:id . 82))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 255) (:start . 253)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "premetamorphic") (:form . "premetamorphic")\n  (:end . 270) (:start . 256) (:id . 84))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 278)\n  (:start . 271) (:id . 85))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 281) (:start . 279)\n  (:id . 86))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 290)\n  (:start . 282) (:id . 87))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 291) (:start . 290)\n  (:id . 88))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 294) (:start . 292)\n  (:id . 89))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 299) (:start . 295)\n  (:id . 90))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 302) (:start . 300)\n  (:id . 91))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 304) (:start . 303)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 312)\n  (:start . 305) (:id . 93))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 324)\n  (:start . 313) (:id . 94))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 327) (:start . 325)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 334)\n  (:start . 328) (:id . 96))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 339) (:start . 335)\n  (:id . 97))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 341) (:start . 340)\n  (:id . 98))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 347)\n  (:start . 342) (:id . 99))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 354)\n  (:start . 348) (:id . 100))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 363)\n  (:start . 355) (:id . 101))\n ((:tag . "NN") (:stem . "regulator") (:form . "regulator") (:end . 373)\n  (:start . 364) (:id . 102))\n ((:tag . "NN") (:stem . "—") (:form . "—") (:end . 374) (:start . 373)\n  (:id . 103))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 377) (:start . 374)\n  (:id . 104))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 382) (:start . 378)\n  (:id . 105))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 392)\n  (:start . 383) (:id . 106))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 400)\n  (:start . 393) (:id . 107))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 401) (:start . 400)\n  (:id . 108)))@@@1@67@((:identifiers (:sid . :s7.35) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102164@unknown@formal@none@1@S@Results@(((:tag . "NNS") (:stem . "result") (:form . "Results") (:end . 7)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s7.36) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102165@unknown@formal@none@1@S@Mutation in the ADGF-A Gene Causes Larval Death and Melanotic Tumors@(((:tag . "NN") (:stem . "mutation") (:form . "Mutation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNP") (:stem . "Gene") (:form . "Gene") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Causes") (:form . "Causes") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "NNP") (:stem . "Larval") (:form . "Larval") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "NNP") (:stem . "Death") (:form . "Death") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Melanotic") (:form . "Melanotic") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "NNPS") (:stem . "Tumor") (:form . "Tumors") (:end . 68)\n  (:start . 62) (:id . 52)))@@@1@11@((:identifiers (:sid . :s7.37) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102166@unknown@formal@none@1@S@We produced mutations in five of the six ADGF genes by homologous recombination mutagenesis [17] and showed that loss of the most abundantly expressed gene, ADGF-A, leads to death in the larval or pupal stage.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "CD") (:stem . "six") (:form . "six") (:end . 40) (:start . 37)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "ADGF") (:form . "ADGF") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 65)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 79) (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "mutagenesis") (:form . "mutagenesis") (:end . 91)\n  (:start . 80) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 117) (:start . 113)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 129) (:start . 125)\n  (:id . 65))\n ((:tag . "RB") (:stem . "abundantly") (:form . "abundantly") (:end . 140)\n  (:start . 130) (:id . 66))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 150)\n  (:start . 141) (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 163)\n  (:start . 157) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 170)\n  (:start . 165) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 179)\n  (:start . 174) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 186) (:start . 183)\n  (:id . 76))\n ((:tag . "NN") (:stem . "larval") (:form . "larval") (:end . 193)\n  (:start . 187) (:id . 77))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 196) (:start . 194)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 202)\n  (:start . 197) (:id . 79))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 208)\n  (:start . 203) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s7.38) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102167@unknown@formal@none@1@S@Under optimal conditions (20–30 isolated homozygous larvae per vial), about 60% of larvae homozygous for the adgf-a mutation reach the third instar.@(((:tag . "IN") (:stem . "under") (:form . "Under") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "optimal") (:form . "optimal") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 26) (:start . 25)\n  (:id . 45))\n ((:tag . "CD") (:stem . "20–30") (:form . "20–30") (:end . 31) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 58)\n  (:start . 52) (:id . 49))\n ((:tag . "IN") (:stem . "per") (:form . "per") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "vial") (:form . "vial") (:end . 67) (:start . 63)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 89)\n  (:start . 83) (:id . 58))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 100)\n  (:start . 90) (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "VBP") (:stem . "reach") (:form . "reach") (:end . 130)\n  (:start . 125) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 140)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 147)\n  (:start . 141) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.39) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102168@unknown@formal@none@1@S@Development during the third larval instar is significantly delayed, and wandering homozygous larvae usually appear 2 d after their heterozygous siblings, which start wandering at about 5 d of development.@(((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 42)\n  (:start . 36) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 48))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 59) (:start . 46) (:id . 49))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 67)\n  (:start . 60) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "wander") (:form . "wandering") (:end . 82)\n  (:start . 73) (:id . 53))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 93)\n  (:start . 83) (:id . 54))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 100)\n  (:start . 94) (:id . 55))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 108)\n  (:start . 101) (:id . 56))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 115)\n  (:start . 109) (:id . 57))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 119) (:start . 118)\n  (:id . 59))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 144)\n  (:start . 132) (:id . 62))\n ((:tag . "NNS") (:stem . "sibling") (:form . "siblings") (:end . 153)\n  (:start . 145) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 160)\n  (:start . 155) (:id . 65))\n ((:tag . "VBP") (:stem . "start") (:form . "start") (:end . 166)\n  (:start . 161) (:id . 66))\n ((:tag . "VBG") (:stem . "wander") (:form . "wandering") (:end . 176)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 185)\n  (:start . 180) (:id . 69))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 187) (:start . 186)\n  (:id . 70))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 189) (:start . 188)\n  (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 192) (:start . 190)\n  (:id . 72))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 204)\n  (:start . 193) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.40) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102170@unknown@formal@none@1@S@Mutant third-instar larvae show fat body disintegration (Figure 1A and 1B) and multiple melanotic tumors (Figure 1C), predominantly in the caudal part of the body and accompanied by disintegration of the fat body.@(((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 55) (:start . 41) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 57) (:start . 56)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "NN") (:stem . "1a") (:form . "1A") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "1b") (:form . "1B") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 87)\n  (:start . 79) (:id . 56))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 104)\n  (:start . 98) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "1c") (:form . "1C") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 63))\n ((:tag . "RB") (:stem . "predominantly") (:form . "predominantly")\n  (:end . 131) (:start . 118) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "caudal") (:form . "caudal") (:end . 145)\n  (:start . 139) (:id . 67))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 153) (:start . 151)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 70))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 162) (:start . 158)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "accompany") (:form . "accompanied") (:end . 178)\n  (:start . 167) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 74))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 196) (:start . 182) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 207) (:start . 204)\n  (:id . 78))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 212) (:start . 208)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s7.42) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102171@unknown@formal@none@1@S@Melanization of the lymph glands was never observed in these larvae, and the imaginal discs and brain appear normal.@(((:tag . "NN") (:stem . "melanization") (:form . "Melanization") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "never") (:form . "never") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 72) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 85)\n  (:start . 77) (:id . 56))\n ((:tag . "NNS") (:stem . "disc") (:form . "discs") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "NN") (:stem . "brain") (:form . "brain") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 108)\n  (:start . 102) (:id . 60))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 115)\n  (:start . 109) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 62)))@@@1@21@((:ncues ((:id . :x7.43.1) (:span 37 42)))\n (:nscopes ((:id . :x7.43.1) (:span 0 67)))\n (:identifiers (:sid . :s7.43) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102172@unknown@formal@none@1@S@Less than 30% of homozygotes eventually pupate.@(((:tag . "RBR") (:stem . "less") (:form . "Less") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 13) (:start . 12)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "homozygote") (:form . "homozygotes") (:end . 28)\n  (:start . 17) (:id . 47))\n ((:tag . "RB") (:stem . "eventually") (:form . "eventually") (:end . 39)\n  (:start . 29) (:id . 48))\n ((:tag . "VBP") (:stem . "pupate") (:form . "pupate") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s7.44) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102173@unknown@formal@none@1@S@Homozygous pupae usually die soon after pupariation; in some cases they develop normal head and thorax imaginal structures; however, abdominal parts usually do not develop.@(((:tag . "JJ") (:stem . "homozygous") (:form . "Homozygous") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "VBP") (:stem . "die") (:form . "die") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "RB") (:stem . "soon") (:form . "soon") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 51)\n  (:start . 40) (:id . 48))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "NN") (:stem . "head") (:form . "head") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thorax") (:form . "thorax") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "JJ") (:stem . "imaginal") (:form . "imaginal") (:end . 111)\n  (:start . 103) (:id . 59))\n ((:tag . "NNS") (:stem . "structure") (:form . "structures") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 131)\n  (:start . 124) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "abdominal") (:form . "abdominal") (:end . 142)\n  (:start . 133) (:id . 64))\n ((:tag . "NNS") (:stem . "part") (:form . "parts") (:end . 148)\n  (:start . 143) (:id . 65))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 156)\n  (:start . 149) (:id . 66))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 163) (:start . 160)\n  (:id . 68))\n ((:tag . "VB") (:stem . "develop") (:form . "develop") (:end . 171)\n  (:start . 164) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x7.45.1) (:span 160 163)))\n (:nscopes ((:id . :x7.45.1) (:span 160 171)))\n (:identifiers (:sid . :s7.45) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102174@unknown@formal@none@1@S@There is also an abnormal curvature (to the right) of the pupal abdomen (Figure 1D).@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 25)\n  (:start . 17) (:id . 46))\n ((:tag . "NN") (:stem . "curvature") (:form . "curvature") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "right") (:form . "right") (:end . 49) (:start . 44)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "NN") (:stem . "abdomen") (:form . "abdomen") (:end . 71)\n  (:start . 64) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 79)\n  (:start . 73) (:id . 58))\n ((:tag . "NN") (:stem . "1d") (:form . "1D") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.46) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102175@unknown@formal@none@1@S@Less than 2% of mutant pupae develop normally and eventually emerge as adults without any obvious abnormalities besides the abdominal curvature; some of them are sterile.@(((:tag . "RBR") (:stem . "less") (:form . "Less") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 22)\n  (:start . 16) (:id . 47))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 28) (:start . 23)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "develop") (:form . "develop") (:end . 36)\n  (:start . 29) (:id . 49))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "eventually") (:form . "eventually") (:end . 60)\n  (:start . 50) (:id . 52))\n ((:tag . "VBP") (:stem . "emerge") (:form . "emerge") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 77)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 85)\n  (:start . 78) (:id . 56))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "obvious") (:form . "obvious") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities")\n  (:end . 111) (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "besides") (:form . "besides") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "abdominal") (:form . "abdominal") (:end . 133)\n  (:start . 124) (:id . 62))\n ((:tag . "NN") (:stem . "curvature") (:form . "curvature") (:end . 143)\n  (:start . 134) (:id . 63))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 66))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 157) (:start . 153)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "sterile") (:form . "sterile") (:end . 169)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x7.47.1) (:span 78 85)))\n (:nscopes ((:id . :x7.47.1) (:span 78 143)))\n (:identifiers (:sid . :s7.47) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102176@unknown@formal@none@1@S@To confirm that the mutant phenotype is caused solely by a mutation in the ADGF-A gene, we created transgenic flies carrying the ADGF-A gene under a heat-shock promoter (HS-ADGF-A).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "confirm") (:form . "confirm") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "RB") (:stem . "solely") (:form . "solely") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 81)\n  (:start . 75) (:id . 56))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "create") (:form . "created") (:end . 98)\n  (:start . 91) (:id . 60))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 109)\n  (:start . 99) (:id . 61))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 115) (:start . 110)\n  (:id . 62))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 135)\n  (:start . 129) (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 140) (:start . 136)\n  (:id . 66))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 148) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "heat-shock") (:form . "heat-shock") (:end . 159)\n  (:start . 149) (:id . 69))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 168)\n  (:start . 160) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 170) (:start . 169)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 179)\n  (:start . 170) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 180) (:start . 179)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x7.48.1) (:span 0 10)))\n (:hscopes ((:id . :x7.48.1) (:span 0 86)))\n (:identifiers (:sid . :s7.48) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102177@unknown@formal@none@1@S@The adgf-a homozygous flies carrying the HS-ADGF-A construct showed survival rates significantly higher than adgf-a even without heat shock, probably due to leaky expression of the HS-ADGF-A construct (Figure 2A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 27) (:start . 22)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 50)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 60)\n  (:start . 51) (:id . 49))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 67) (:start . 61)\n  (:id . 50))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "NNS") (:stem . "rate") (:form . "rates") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 96) (:start . 83) (:id . 53))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 103)\n  (:start . 97) (:id . 54))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 108) (:start . 104)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 115)\n  (:start . 109) (:id . 56))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 120) (:start . 116)\n  (:id . 57))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 128)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 133) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "shock") (:form . "shock") (:end . 139)\n  (:start . 134) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 149)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 153) (:start . 150)\n  (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 156) (:start . 154)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "leaky") (:form . "leaky") (:end . 162)\n  (:start . 157) (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 190)\n  (:start . 181) (:id . 69))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 200)\n  (:start . 191) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 208)\n  (:start . 202) (:id . 72))\n ((:tag . "NN") (:stem . "2a") (:form . "2A") (:end . 211) (:start . 209)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 212) (:start . 211)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 213) (:start . 212)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x7.49.1) (:span 141 149)))\n (:ncues ((:id . :x7.49.2) (:span 121 128)))\n (:hscopes ((:id . :x7.49.1) (:span 141 200)))\n (:nscopes ((:id . :x7.49.2) (:span 121 139)))\n (:identifiers (:sid . :s7.49) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102178@unknown@formal@none@1@S@However, while non-heat shocked animals still produced many melanotic tumors, only 22% of animals that were heat shocked as late embryos/early first instar developed these tumors (Figure 2B).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "non-heat") (:form . "non-heat") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "shocked") (:form . "shocked") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 39)\n  (:start . 32) (:id . 47))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 45) (:start . 40)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 59) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 82) (:start . 78)\n  (:id . 54))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 97)\n  (:start . 90) (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 102) (:start . 98)\n  (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "shock") (:form . "shocked") (:end . 120)\n  (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 128) (:start . 124)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "embryos/early") (:form . "embryos/early")\n  (:end . 142) (:start . 129) (:id . 65))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 148)\n  (:start . 143) (:id . 66))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 155)\n  (:start . 149) (:id . 67))\n ((:tag . "VBD") (:stem . "develop") (:form . "developed") (:end . 165)\n  (:start . 156) (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 171)\n  (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 178)\n  (:start . 172) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 186)\n  (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "2b") (:form . "2B") (:end . 189) (:start . 187)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 190) (:start . 189)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s7.50) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102180@unknown@formal@none@1@S@This conclusion is further supported by the even more efficient rescue achieved by expression of transgenically provided ADGF-A in the lymph glands using the Gal4/UAS system (see below).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "efficient") (:form . "efficient") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 70)\n  (:start . 64) (:id . 52))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 93)\n  (:start . 83) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "RB") (:stem . "transgenically") (:form . "transgenically")\n  (:end . 111) (:start . 97) (:id . 57))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 120)\n  (:start . 112) (:id . 58))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 127)\n  (:start . 121) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 140)\n  (:start . 135) (:id . 62))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 147)\n  (:start . 141) (:id . 63))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 153) (:start . 148)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Gal4/UAS") (:form . "Gal4/UAS") (:end . 166)\n  (:start . 158) (:id . 66))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 68))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 178) (:start . 175)\n  (:id . 69))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 184)\n  (:start . 179) (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.52) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102181@unknown@formal@none@1@S@adgf-a Mutant Phenotype@(((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 23)\n  (:start . 14) (:id . 44)))@@@1@3@((:identifiers (:sid . :s7.53) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102182@unknown@formal@none@1@S@(A and B) Fat body disintegration visualized by GFP expression driven by Cg-Gal4 driver in the fat body.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . "NNP") (:stem . "Fat") (:form . "Fat") (:end . 13) (:start . 10)\n  (:id . 47))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 18) (:start . 14)\n  (:id . 48))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 33) (:start . 19) (:id . 49))\n ((:tag . "VBN") (:stem . "visualize") (:form . "visualized") (:end . 44)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 51) (:start . 48)\n  (:id . 52))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 62)\n  (:start . 52) (:id . 53))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 69)\n  (:start . 63) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 72) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "cg-gal4") (:form . "Cg-Gal4") (:end . 80)\n  (:start . 73) (:id . 56))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 103) (:start . 99)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 104) (:start . 103)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s7.54) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102183@unknown@formal@none@1@S@While adgf-a/+ heterozygous third instar larvae have normal flat layers of fat body (A),adgf-a mutant showed extensive fat body disintegration into small pieces of tissue (B).@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adgf-a/+") (:form . "adgf-a/+") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 27)\n  (:start . 15) (:id . 44))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 33) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 40)\n  (:start . 34) (:id . 46))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 47)\n  (:start . 41) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 52) (:start . 48)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 59)\n  (:start . 53) (:id . 49))\n ((:tag . "JJ") (:stem . "flat") (:form . "flat") (:end . 64) (:start . 60)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "layer") (:form . "layers") (:end . 71)\n  (:start . 65) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 52))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "A),adgf-a") (:form . "A),adgf-a") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 101)\n  (:start . 95) (:id . 57))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 108)\n  (:start . 102) (:id . 58))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 127) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 142) (:start . 128) (:id . 62))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 147) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 153)\n  (:start . 148) (:id . 64))\n ((:tag . "NNS") (:stem . "piece") (:form . "pieces") (:end . 160)\n  (:start . 154) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 173) (:start . 172)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 174) (:start . 173)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s7.55) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102184@unknown@formal@none@1@S@(C) Multiple melanotic tumors present in adgf-a mutant third-instar larva.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 12)\n  (:start . 4) (:id . 45))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 22)\n  (:start . 13) (:id . 46))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 47)\n  (:start . 41) (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 67)\n  (:start . 55) (:id . 52))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.56) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102185@unknown@formal@none@1@S@(D) An adgf-a mutant pupa with typical abdominal curvature.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "An") (:end . 6) (:start . 4)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 13) (:start . 7)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 20)\n  (:start . 14) (:id . 47))\n ((:tag . "NN") (:stem . "pupa") (:form . "pupa") (:end . 25) (:start . 21)\n  (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 30) (:start . 26)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 38)\n  (:start . 31) (:id . 50))\n ((:tag . "JJ") (:stem . "abdominal") (:form . "abdominal") (:end . 48)\n  (:start . 39) (:id . 51))\n ((:tag . "NN") (:stem . "curvature") (:form . "curvature") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 59) (:start . 58)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.57) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102186@unknown@formal@none@1@S@Rescue of the adgf-a Mutant Phenotype by Expression of ADGF-A in Different Tissues@(((:tag . "NN") (:stem . "rescue") (:form . "Rescue") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "different") (:form . "Different") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "NNPS") (:stem . "Tissue") (:form . "Tissues") (:end . 82)\n  (:start . 75) (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.58) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102187@unknown@formal@none@1@S@(A) Percentage of pupae (blue bars) and adult flies (purple bars) demonstrating the larval and pupal survival, respectively, of the adgf-a mutant flies rescued by expression of transgenic ADGF-A in different tissues.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "percentage") (:form . "Percentage") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pupae") (:form . "pupae") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 25) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 29) (:start . 25)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 34) (:start . 30)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 35) (:start . 34)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 45) (:start . 40)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 51) (:start . 46)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "purple") (:form . "purple") (:end . 59)\n  (:start . 53) (:id . 56))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 64) (:start . 60)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 65) (:start . 64)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating") (:end . 79)\n  (:start . 66) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 90)\n  (:start . 84) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 100) (:start . 95)\n  (:id . 63))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 109)\n  (:start . 101) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 65))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 123)\n  (:start . 111) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 138)\n  (:start . 132) (:id . 70))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 145)\n  (:start . 139) (:id . 71))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 151) (:start . 146)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 159)\n  (:start . 152) (:id . 73))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 162) (:start . 160)\n  (:id . 74))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 173)\n  (:start . 163) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 187)\n  (:start . 177) (:id . 77))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "ADGF-A") (:end . 194)\n  (:start . 188) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 197) (:start . 195)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 207)\n  (:start . 198) (:id . 80))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 215)\n  (:start . 208) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s7.59) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102188@unknown@formal@none@1@S@Along the x-axis (which is shared with [B]), the rescue experiments are shown (marked by the Gal4 driver used for expression of ADGF-A except for first three sets of bars—the first set presents only an adgf-a mutant, the second an adgf-a mutant carrying HS-ADGF-A construct without heat shock, and the third with heat shock) and the y-axis represents percentage of pupae and adult flies out of the total number of transferred first-instar larvae of particular genotype.@(((:tag . "IN") (:stem . "along") (:form . "Along") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . 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(:end . 469) (:start . 468)\n  (:id . 129)))@@@1@88@((:ncues ((:id . :x7.60.1) (:span 274 281)))\n (:nscopes ((:id . :x7.60.1) (:span 274 292)))\n (:identifiers (:sid . :s7.60) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102190@unknown@formal@none@1@S@(B) Percentage of late third-instar larvae with melanotic tumors.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "percentage") (:form . "Percentage") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.62) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102191@unknown@formal@none@1@S@The x-axis is shared with (A) (described above).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 28) (:start . 27)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 29) (:start . 28)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 40)\n  (:start . 31) (:id . 51))\n ((:tag . "IN") (:stem . "above") (:form . "above") (:end . 46) (:start . 41)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 47) (:start . 46)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 48) (:start . 47)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.63) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102192@unknown@formal@none@1@S@The y-axis shows the percentage of larvae with tumors out of all larvae of each genotype examined for (A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 64) (:start . 61)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 71)\n  (:start . 65) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "genotype") (:form . "genotype") (:end . 88)\n  (:start . 80) (:id . 57))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 97)\n  (:start . 89) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 101) (:start . 98)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 104) (:start . 103)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.64) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102193@unknown@formal@none@1@S@The adgf-a Mutant Phenotype Is Associated with Elevated Levels of Adenosine and/or Deoxyadenosine@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "associate") (:form . "Associated") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "elevated") (:form . "Elevated") (:end . 55)\n  (:start . 47) (:id . 49))\n ((:tag . "NNPS") (:stem . "Level") (:form . "Levels") (:end . 62)\n  (:start . 56) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 82)\n  (:start . 76) (:id . 53))\n ((:tag . "NNP") (:stem . "Deoxyadenosine") (:form . "Deoxyadenosine")\n  (:end . 97) (:start . 83) (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.65) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102194@unknown@formal@none@1@S@Using liquid chromatography and mass spectrometry of deproteinated hemolymph samples, we measured adenosine concentrations in hemolymph of mutant and wild-type third-instar larvae.@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "liquid") (:form . "liquid") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 27) (:start . 13) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 31) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "spectrometry") (:form . "spectrometry") (:end . 49)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "deproteinate") (:form . "deproteinated")\n  (:end . 66) (:start . 53) (:id . 49))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 76)\n  (:start . 67) (:id . 50))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 84)\n  (:start . 77) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "measure") (:form . "measured") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 107)\n  (:start . 98) (:id . 55))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 122) (:start . 108) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 125) (:start . 123)\n  (:id . 57))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 135)\n  (:start . 126) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 138) (:start . 136)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 145)\n  (:start . 139) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 149) (:start . 146)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 159)\n  (:start . 150) (:id . 62))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 172)\n  (:start . 160) (:id . 63))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 179)\n  (:start . 173) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.66) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102195@unknown@formal@none@1@S@The adenosine concentration in the adgf-a mutant was 1.14 ± 0.26 ?M compared to less than 0.08 ?M in the wild type, and the deoxyadenosine concentration in mutants was 1.66 ± 0.99 ?M compared to an undetectable level in the wild type.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 27) (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1.14") (:form . "1.14") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "IN") (:stem . "±") (:form . "±") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "CD") (:stem . "0.26") (:form . "0.26") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "?M") (:form . "?M") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 76)\n  (:start . 68) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 84) (:start . 80)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "CD") (:stem . "0.08") (:form . "0.08") (:end . 94) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "?M") (:form . "?M") (:end . 97) (:start . 95)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 109) (:start . 105)\n  (:id . 62))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 114) (:start . 110)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 123) (:start . 120)\n  (:id . 66))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 138) (:start . 124) (:id . 67))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 152) (:start . 139) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 163)\n  (:start . 156) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "CD") (:stem . "1.66") (:form . "1.66") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "IN") (:stem . "±") (:form . "±") (:end . 174) (:start . 173)\n  (:id . 73))\n ((:tag . "CD") (:stem . "0.99") (:form . "0.99") (:end . 179) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "?M") (:form . "?M") (:end . 182) (:start . 180)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 191)\n  (:start . 183) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 194) (:start . 192)\n  (:id . 77))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 197) (:start . 195)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "undetectable") (:form . "undetectable") (:end . 210)\n  (:start . 198) (:id . 79))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 216)\n  (:start . 211) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 219) (:start . 217)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 228) (:start . 224)\n  (:id . 83))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 233) (:start . 229)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s7.67) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102196@unknown@formal@none@1@S@The Catalytic Activity of ADGF-A Is Required for Its Function@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "Catalytic") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "activity") (:form . "Activity") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Required") (:form . "Required") (:end . 44)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "PRP$") (:stem . "its") (:form . "Its") (:end . 52) (:start . 49)\n  (:id . 50))\n ((:tag . "NN") (:stem . "function") (:form . "Function") (:end . 61)\n  (:start . 53) (:id . 51)))@@@1@10@((:identifiers (:sid . :s7.68) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102197@unknown@formal@none@1@S@To test whether the function of ADGF-A in vivo is also dependent on its catalytic activity, we produced two versions of the UAS-ADGF-A construct [18]: one carrying wild-type cDNA of ADGF-A and one carrying an ADGF-A cDNA with a mutation causing a substitution of two amino acids (H386G and A387E) in the catalytic domain [16].@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . 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"carrying") (:end . 205)\n  (:start . 197) (:id . 79))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 208) (:start . 206)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 215)\n  (:start . 209) (:id . 81))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 220) (:start . 216)\n  (:id . 82))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 225) (:start . 221)\n  (:id . 83))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 227) (:start . 226)\n  (:id . 84))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 236)\n  (:start . 228) (:id . 85))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 244)\n  (:start . 237) (:id . 86))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 246) (:start . 245)\n  (:id . 87))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 259)\n  (:start . 247) (:id . 88))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 262) (:start . 260)\n  (:id . 89))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 266) (:start . 263)\n  (:id . 90))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 272)\n  (:start . 267) (:id . 91))\n ((:tag . "NNS") (:stem . "acid") (:form . "acids") (:end . 278)\n  (:start . 273) (:id . 92))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 280) (:start . 279)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "H386G") (:form . "H386G") (:end . 285)\n  (:start . 280) (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 289) (:start . 286)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "A387E") (:form . "A387E") (:end . 295)\n  (:start . 290) (:id . 96))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 296) (:start . 295)\n  (:id . 97))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 299) (:start . 297)\n  (:id . 98))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 303) (:start . 300)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 313)\n  (:start . 304) (:id . 100))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 320)\n  (:start . 314) (:id . 101))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 322) (:start . 321)\n  (:id . 102))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 324) (:start . 322)\n  (:id . 103))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 325) (:start . 324)\n  (:id . 104))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 326) (:start . 325)\n  (:id . 105)))@@@1@64@((:hcues ((:id . :x7.69.1) (:span 8 15)))\n (:hscopes ((:id . :x7.69.1) (:span 8 90)))\n (:identifiers (:sid . :s7.69) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102198@unknown@formal@none@1@S@Two different lines carrying the wild-type UAS-ADGF-A expression construct together with an Actin-Gal4 driver (providing ubiquitous expression) both completely rescued the mutant phenotype, whereas larvae with UAS-ADGF-A but without the driver showed the typical mutant phenotype.@(((:tag . "CD") (:stem . "two") (:form . "Two") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "NNP") (:stem . "UAS-ADGF-A") (:form . "UAS-ADGF-A") (:end . 53)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 74)\n  (:start . 65) (:id . 50))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 83)\n  (:start . 75) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 88) (:start . 84)\n  (:id . 52))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 53))\n ((:tag . "NN") (:stem . "actin-gal4") (:form . "Actin-Gal4") (:end . 102)\n  (:start . 92) (:id . 54))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 109)\n  (:start . 103) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 111) (:start . 110)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "provide") (:form . "providing") (:end . 120)\n  (:start . 111) (:id . 57))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 131)\n  (:start . 121) (:id . 58))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 142)\n  (:start . 132) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 60))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 148) (:start . 144)\n  (:id . 61))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 159)\n  (:start . 149) (:id . 62))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 167)\n  (:start . 160) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 178)\n  (:start . 172) (:id . 65))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 188)\n  (:start . 179) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 67))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 197)\n  (:start . 190) (:id . 68))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 204)\n  (:start . 198) (:id . 69))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 209) (:start . 205)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "UAS-ADGF-A") (:form . "UAS-ADGF-A") (:end . 220)\n  (:start . 210) (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 224) (:start . 221)\n  (:id . 72))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 232)\n  (:start . 225) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 236) (:start . 233)\n  (:id . 74))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 243)\n  (:start . 237) (:id . 75))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 250)\n  (:start . 244) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 254) (:start . 251)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 262)\n  (:start . 255) (:id . 78))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 269)\n  (:start . 263) (:id . 79))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 279)\n  (:start . 270) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 280) (:start . 279)\n  (:id . 81)))@@@1@40@((:ncues ((:id . :x7.70.1) (:span 225 232)))\n (:nscopes ((:id . :x7.70.1) (:span 225 243)))\n (:identifiers (:sid . :s7.70) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102200@unknown@formal@none@1@S@This result therefore demonstrates that the catalytic activity of ADGF-A is required for its function in vivo.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBZ") (:stem . "demonstrate") (:form . "demonstrates") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 53)\n  (:start . 44) (:id . 48))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 72)\n  (:start . 66) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 84)\n  (:start . 76) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 101)\n  (:start . 93) (:id . 56))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 57))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.72) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102201@unknown@formal@none@1@S@Hemocyte Development Is Affected in the adgf-a Mutant@(((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocyte") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "affect") (:form . "Affected") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "Mutant") (:form . "Mutant") (:end . 53)\n  (:start . 47) (:id . 49)))@@@1@8@((:identifiers (:sid . :s7.73) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102202@unknown@formal@none@1@S@We investigated the number and morphology of hemocytes (blood cells) in the hemolymph of the adgf-a late third-instar larvae (Figures 3 and 4).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "investigate") (:form . "investigated") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 26)\n  (:start . 20) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 67) (:start . 62)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 55))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 85)\n  (:start . 76) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 99)\n  (:start . 93) (:id . 59))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 117)\n  (:start . 105) (:id . 61))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 124)\n  (:start . 118) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 133)\n  (:start . 126) (:id . 64))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "CD") (:stem . "4") (:form . "4") (:end . 141) (:start . 140)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.74) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102203@unknown@formal@none@1@S@These larvae contain an average of seven-fold more hemocytes in circulation than wild-type larvae (Figure 3).@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 20)\n  (:start . 13) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "seven-fold") (:form . "seven-fold") (:end . 45)\n  (:start . 35) (:id . 48))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "circulation") (:form . "circulation") (:end . 75)\n  (:start . 64) (:id . 52))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 97)\n  (:start . 91) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 99) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s7.75) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102204@unknown@formal@none@1@S@In contrast to normal larval plasmatocytes, which remain rounded after settling down on the substrate (Figure 4A), most of the cells in the adgf-a mutant (more than 75%) are strongly adhesive and, after they are deposited in a drop of hemolymph on a microscope slide, develop filamentous and membranous extensions (Figure 4B–4D).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "plasmatocyte") (:form . "plasmatocytes")\n  (:end . 42) (:start . 29) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . 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"extensions") (:end . 313)\n  (:start . 303) (:id . 100))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 315) (:start . 314)\n  (:id . 101))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 321)\n  (:start . 315) (:id . 102))\n ((:tag . "NNP") (:stem . "4B–4D") (:form . "4B–4D") (:end . 327)\n  (:start . 322) (:id . 103))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 328) (:start . 327)\n  (:id . 104))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 329) (:start . 328)\n  (:id . 105)))@@@1@64@((:identifiers (:sid . :s7.76) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102205@unknown@formal@none@1@S@An average of 7% of hemocytes in the adgf-a mutant are lamellocytes (Figures 3 and 4E), large flat cells that are not present in circulation of wild-type larvae under normal conditions [19].@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "average") (:form . "average") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 29)\n  (:start . 20) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 43)\n  (:start . 37) (:id . 51))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 54) (:start . 51)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "lamellocyte") (:form . "lamellocytes") (:end . 67)\n  (:start . 55) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "figure") (:form . "Figures") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 78) (:start . 77)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 58))\n ((:tag . "NN") (:stem . "4e") (:form . "4E") (:end . 85) (:start . 83)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 93) (:start . 88)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "flat") (:form . "flat") (:end . 98) (:start . 94)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 104) (:start . 99)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 66))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 117) (:start . 114)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 125)\n  (:start . 118) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 69))\n ((:tag . "NN") (:stem . "circulation") (:form . "circulation") (:end . 140)\n  (:start . 129) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 153)\n  (:start . 144) (:id . 72))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 160)\n  (:start . 154) (:id . 73))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 166)\n  (:start . 161) (:id . 74))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 173)\n  (:start . 167) (:id . 75))\n ((:tag . "NNS") (:stem . "condition") (:form . "conditions") (:end . 184)\n  (:start . 174) (:id . 76))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 186) (:start . 185)\n  (:id . 77))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 188) (:start . 186)\n  (:id . 78))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 189) (:start . 188)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x7.77.1) (:span 114 117)))\n (:nscopes ((:id . :x7.77.1) (:span 114 184)))\n (:identifiers (:sid . :s7.77) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102206@unknown@formal@none@1@S@Crystal cells were also detected in excess, with mutant larvae carrying several hundred while there are fewer than a hundred of these cells in the wild type (Figure 5).@(((:tag . "JJ") (:stem . "crystal") (:form . "Crystal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "excess") (:form . "excess") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 55)\n  (:start . 49) (:id . 51))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 62)\n  (:start . 56) (:id . 52))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 71)\n  (:start . 63) (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "CD") (:stem . "hundred") (:form . "hundred") (:end . 87)\n  (:start . 80) (:id . 55))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 93) (:start . 88)\n  (:id . 56))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 99) (:start . 94)\n  (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "few") (:form . "fewer") (:end . 109) (:start . 104)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "CD") (:stem . "hundred") (:form . "hundred") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 133)\n  (:start . 128) (:id . 64))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 151) (:start . 147)\n  (:id . 68))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 164)\n  (:start . 158) (:id . 71))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 166) (:start . 165)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.78) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102207@unknown@formal@none@1@S@The lymph glands normally do not release hemocytes into the hemolymph before metamorphosis [20]; instead, they are released during metamorphosis when the lymph glands disperse [19].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VB") (:stem . "release") (:form . "release") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 90) (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "CD") (:stem . "20") (:form . "20") (:end . 94) (:start . 92)\n  (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 104)\n  (:start . 97) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 110) (:start . 106)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 114) (:start . 111)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 123)\n  (:start . 115) (:id . 63))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 130)\n  (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 144) (:start . 131) (:id . 65))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 149) (:start . 145)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 67))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 159)\n  (:start . 154) (:id . 68))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 166)\n  (:start . 160) (:id . 69))\n ((:tag . "VBP") (:stem . "disperse") (:form . "disperse") (:end . 175)\n  (:start . 167) (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 180) (:start . 179)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 74)))@@@1@33@((:ncues ((:id . :x7.79.1) (:span 29 32)))\n (:nscopes ((:id . :x7.79.1) (:span 29 90)))\n (:identifiers (:sid . :s7.79) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102208@unknown@formal@none@1@S@However, the lymph glands of adgf-a mutant larvae are already dispersed in the late third instar.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 35)\n  (:start . 29) (:id . 48))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 49)\n  (:start . 43) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 61)\n  (:start . 54) (:id . 52))\n ((:tag . "VBN") (:stem . "disperse") (:form . "dispersed") (:end . 71)\n  (:start . 62) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 89) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.80) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102210@unknown@formal@none@1@S@To analyze hemocytes in living larvae, we used the Hemolectin marker (Hml) [21].@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "analyze") (:form . "analyze") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 30) (:start . 24)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 41) (:start . 39)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Hemolectin") (:form . "Hemolectin") (:end . 61)\n  (:start . 51) (:id . 52))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 68)\n  (:start . 62) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Hml") (:form . "Hml") (:end . 73) (:start . 70)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 74) (:start . 73)\n  (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 76) (:start . 75)\n  (:id . 57))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 78) (:start . 76)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 79) (:start . 78)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s7.82) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102211@unknown@formal@none@1@S@We compared the number and distribution of hemocytes stained by GFP in flies carrying hml-Gal4 UAS-GFP in wild-type and mutant backgrounds.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "compare") (:form . "compared") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 39)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 60)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 85)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "hml-gal4") (:form . "hml-Gal4") (:end . 94)\n  (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "uas-gfp") (:form . "UAS-GFP") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 115)\n  (:start . 106) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 126)\n  (:start . 120) (:id . 61))\n ((:tag . "NNS") (:stem . "background") (:form . "backgrounds") (:end . 138)\n  (:start . 127) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 139) (:start . 138)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.83) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102212@unknown@formal@none@1@S@While there are relatively few hemocytes, mostly free-floating in the hemolymph, in early third-instar wild-type larvae (see Figure 4I), a much higher number of hemocytes, which are mostly attached to the tissues under the integument (described as sessile hemocytes in [19]), was observed in mutant larvae (see Figure 4J).@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 11) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 40)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 48))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "JJ") (:stem . "free-floating") (:form . "free-floating")\n  (:end . 62) (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 79)\n  (:start . 70) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 102)\n  (:start . 90) (:id . 57))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 119)\n  (:start . 113) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 124) (:start . 121)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 131)\n  (:start . 125) (:id . 62))\n ((:tag . "NN") (:stem . "4i") (:form . "4I") (:end . 134) (:start . 132)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 138) (:start . 137)\n  (:id . 66))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 143) (:start . 139)\n  (:id . 67))\n ((:tag . "JJR") (:stem . "high") (:form . "higher") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 157)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 170)\n  (:start . 161) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 177)\n  (:start . 172) (:id . 73))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 181) (:start . 178)\n  (:id . 74))\n ((:tag . "RB") (:stem . "mostly") (:form . "mostly") (:end . 188)\n  (:start . 182) (:id . 75))\n ((:tag . "VBN") (:stem . "attach") (:form . "attached") (:end . 197)\n  (:start . 189) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 200) (:start . 198)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 212)\n  (:start . 205) (:id . 79))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 218)\n  (:start . 213) (:id . 80))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 81))\n ((:tag . "NN") (:stem . "integument") (:form . "integument") (:end . 233)\n  (:start . 223) (:id . 82))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 235) (:start . 234)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 244)\n  (:start . 235) (:id . 84))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 247) (:start . 245)\n  (:id . 85))\n ((:tag . "NN") (:stem . "sessile") (:form . "sessile") (:end . 255)\n  (:start . 248) (:id . 86))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 265)\n  (:start . 256) (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 268) (:start . 266)\n  (:id . 88))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 270) (:start . 269)\n  (:id . 89))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 272) (:start . 270)\n  (:id . 90))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 273) (:start . 272)\n  (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 274) (:start . 273)\n  (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 275) (:start . 274)\n  (:id . 93))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 279) (:start . 276)\n  (:id . 94))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 288)\n  (:start . 280) (:id . 95))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 291) (:start . 289)\n  (:id . 96))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 298)\n  (:start . 292) (:id . 97))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 305)\n  (:start . 299) (:id . 98))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 307) (:start . 306)\n  (:id . 99))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 310) (:start . 307)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 317)\n  (:start . 311) (:id . 101))\n ((:tag . "NN") (:stem . "4j") (:form . "4J") (:end . 320) (:start . 318)\n  (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 321) (:start . 320)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 322) (:start . 321)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s7.84) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102213@unknown@formal@none@1@S@A similar behavior was detected later in wild-type larvae, toward the end of the third instar (see Figure 4H).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "behavior") (:form . "behavior") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "RB") (:stem . "later") (:form . "later") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "toward") (:form . "toward") (:end . 65)\n  (:start . 59) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 93)\n  (:start . 87) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 59))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 105)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "4h") (:form . "4H") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 109) (:start . 108)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.85) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102214@unknown@formal@none@1@S@At this stage, the Hml marker disappeared from the most of the hemocytes in mutants (see Figure 4F and 4G).@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Hml") (:form . "Hml") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 29)\n  (:start . 23) (:id . 48))\n ((:tag . "VBD") (:stem . "disappear") (:form . "disappeared") (:end . 41)\n  (:start . 30) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 46) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 72)\n  (:start . 63) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 83)\n  (:start . 76) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 88) (:start . 85)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 95)\n  (:start . 89) (:id . 60))\n ((:tag . "NN") (:stem . "4f") (:form . "4F") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "4g") (:form . "4G") (:end . 105) (:start . 103)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 106) (:start . 105)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.86) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102215@unknown@formal@none@1@S@Number of Circulating Hemocytes in Late Third-Instar Larvae@(((:tag . "NN") (:stem . "number") (:form . "Number") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "circulate") (:form . "Circulating") (:end . 21)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "Hemocytes") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Late") (:form . "Late") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Third-Instar") (:form . "Third-Instar") (:end . 52)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "Larvae") (:form . "Larvae") (:end . 59)\n  (:start . 53) (:id . 49)))@@@1@8@((:identifiers (:sid . :s7.87) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102216@unknown@formal@none@1@S@Genotypes are shown along the x-axis, and the number of hemocytes/larva along the y-axis.@(((:tag . "NNS") (:stem . "genotype") (:form . "Genotypes") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 19) (:start . 14)\n  (:id . 44))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 25) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NN") (:stem . "hemocytes/larva") (:form . "hemocytes/larva")\n  (:end . 71) (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 88)\n  (:start . 82) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s7.88) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102217@unknown@formal@none@1@S@Each bar shows the number of all circulating hemocytes, and the gray part of the bars represent the lamellocyte population.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 44)\n  (:start . 33) (:id . 49))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "gray") (:form . "gray") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 73) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "represent") (:form . "represent") (:end . 95)\n  (:start . 86) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "lamellocyte") (:form . "lamellocyte") (:end . 111)\n  (:start . 100) (:id . 61))\n ((:tag . "NN") (:stem . "population") (:form . "population") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.89) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102218@unknown@formal@none@1@S@Each count was repeated five to ten times and the standard error is shown.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "count") (:form . "count") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "CD") (:stem . "five") (:form . "five") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 47))\n ((:tag . "CD") (:stem . "ten") (:form . "ten") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 41) (:start . 36)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s7.90) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102220@unknown@formal@none@1@S@(A–E) Differential interference contrast microscopy of living circulating hemocytes (magnification 200×; scale bar, 10 ?m).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "A–E") (:form . "A–E") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 18)\n  (:start . 6) (:id . 45))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 51)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 61) (:start . 55)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 73)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 83)\n  (:start . 74) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 53))\n ((:tag . "NN") (:stem . "magnification") (:form . "magnification")\n  (:end . 98) (:start . 85) (:id . 54))\n ((:tag . "CD") (:stem . "200×") (:form . "200×") (:end . 103) (:start . 99)\n  (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 104) (:start . 103)\n  (:id . 56))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 110)\n  (:start . 105) (:id . 57))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 59))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 123) (:start . 122)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.92) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102221@unknown@formal@none@1@S@Round, nonadhesive plasmatocytes from wild-type larva (A).@(((:tag . "NNP") (:stem . "Round") (:form . "Round") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "JJ") (:stem . "nonadhesive") (:form . "nonadhesive") (:end . 18)\n  (:start . 7) (:id . 44))\n ((:tag . "NNS") (:stem . "plasmatocyte") (:form . "plasmatocytes")\n  (:end . 32) (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 37) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 47)\n  (:start . 38) (:id . 47))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 53) (:start . 48)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 55) (:start . 54)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "A") (:form . "A") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s7.93) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102222@unknown@formal@none@1@S@Hemocytes from the adgf-a mutant developing filamentous extensions (B and C) or membranous extension surrounding the cell (D).@(((:tag . "NNS") (:stem . "hemocyte") (:form . "Hemocytes") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 43)\n  (:start . 33) (:id . 47))\n ((:tag . "JJ") (:stem . "filamentous") (:form . "filamentous") (:end . 55)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "extension") (:form . "extensions") (:end . 66)\n  (:start . 56) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 69) (:start . 68)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "membranous") (:form . "membranous") (:end . 90)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "extension") (:form . "extension") (:end . 100)\n  (:start . 91) (:id . 57))\n ((:tag . "VBG") (:stem . "surround") (:form . "surrounding") (:end . 112)\n  (:start . 101) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 124) (:start . 123)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.94) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102223@unknown@formal@none@1@S@Large flat lamellocyte from the adgf-a mutant (E).@(((:tag . "JJ") (:stem . "large") (:form . "Large") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "flat") (:form . "flat") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "lamellocyte") (:form . "lamellocyte") (:end . 22)\n  (:start . 11) (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 45)\n  (:start . 39) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "e") (:form . "E") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 50) (:start . 49)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s7.95) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102224@unknown@formal@none@1@S@(F and G) Differential interference contrast and fluorescent microscopy (merged image) of living circulating hemocytes stained by the Hml-GFP marker (magnification 100×; scale bar, 10 ?m).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "F") (:form . "F") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . "JJ") (:stem . "differential") (:form . "Differential") (:end . 22)\n  (:start . 10) (:id . 47))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 44)\n  (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 48) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "fluorescent") (:form . "fluorescent") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "merged") (:form . "merged") (:end . 79)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "image") (:form . "image") (:end . 85) (:start . 80)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 96) (:start . 90)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 108)\n  (:start . 97) (:id . 59))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 118)\n  (:start . 109) (:id . 60))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 126)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Hml-GFP") (:form . "Hml-GFP") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "NN") (:stem . "marker") (:form . "marker") (:end . 148)\n  (:start . 142) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 150) (:start . 149)\n  (:id . 66))\n ((:tag . "NN") (:stem . "magnification") (:form . "magnification")\n  (:end . 163) (:start . 150) (:id . 67))\n ((:tag . "CD") (:stem . "100×") (:form . "100×") (:end . 168) (:start . 164)\n  (:id . 68))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 169) (:start . 168)\n  (:id . 69))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 72))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 183) (:start . 181)\n  (:id . 73))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 186) (:start . 184)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 187) (:start . 186)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s7.96) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102225@unknown@formal@none@1@S@While most of the cells from wild-type larvae are GFP-positive (F), just few of the cells from late third instar adgf-a larvae are stained by GFP at this stage (G).@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 38)\n  (:start . 29) (:id . 48))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "gfp-positive") (:form . "GFP-positive") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 65) (:start . 64)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 72) (:start . 68)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "few") (:form . "few") (:end . 76) (:start . 73)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 89) (:start . 84)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 94) (:start . 90)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 99) (:start . 95)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 105)\n  (:start . 100) (:id . 63))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 112)\n  (:start . 106) (:id . 64))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 119)\n  (:start . 113) (:id . 65))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 126)\n  (:start . 120) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 130) (:start . 127)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "stain") (:form . "stained") (:end . 138)\n  (:start . 131) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 145) (:start . 142)\n  (:id . 70))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 148) (:start . 146)\n  (:id . 71))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 153) (:start . 149)\n  (:id . 72))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 159)\n  (:start . 154) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "G") (:form . "G") (:end . 162) (:start . 161)\n  (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 163) (:start . 162)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s7.97) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102226@unknown@formal@none@1@S@(H–J) Fluorescence microscopy of living larvae with Hml-GFP stained hemocytes (magnification 40×; scale bar, 100 ?m).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "H–J") (:form . "H–J") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "NNP") (:stem . "Fluorescence") (:form . "Fluorescence") (:end . 18)\n  (:start . 6) (:id . 45))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 39) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Hml-GFP") (:form . "Hml-GFP") (:end . 59)\n  (:start . 52) (:id . 51))\n ((:tag . "VBD") (:stem . "stain") (:form . "stained") (:end . 67)\n  (:start . 60) (:id . 52))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 77)\n  (:start . 68) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 79) (:start . 78)\n  (:id . 54))\n ((:tag . "NN") (:stem . "magnification") (:form . "magnification")\n  (:end . 92) (:start . 79) (:id . 55))\n ((:tag . "CD") (:stem . "40×") (:form . "40×") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 97) (:start . 96)\n  (:id . 57))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 103) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "CD") (:stem . "100") (:form . "100") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "?m") (:form . "?m") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.98) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102227@unknown@formal@none@1@S@Posterior part of late third-instar wild-type larva (H).@(((:tag . "JJ") (:stem . "posterior") (:form . "Posterior") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 35)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 51) (:start . 46)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "H") (:form . "H") (:end . 54) (:start . 53)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 56) (:start . 55)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s7.99) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102228@unknown@formal@none@1@S@Middle sections of early third-instar larvae of wild type (I) and adgf-a mutant (J).@(((:tag . "JJ") (:stem . "middle") (:form . "Middle") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "section") (:form . "sections") (:end . 15)\n  (:start . 7) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 37)\n  (:start . 25) (:id . 46))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 44)\n  (:start . 38) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "i") (:form . "I") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 72)\n  (:start . 66) (:id . 55))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 79)\n  (:start . 73) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "J") (:form . "J") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s7.100) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102230@unknown@formal@none@1@S@Crystal cells were visualized by heating larvae of different genotypes at 60 °C for 10 min [46].@(((:tag . "JJ") (:stem . "crystal") (:form . "Crystal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "visualize") (:form . "visualized") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "heat") (:form . "heating") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 60)\n  (:start . 51) (:id . 50))\n ((:tag . "NNS") (:stem . "genotype") (:form . "genotypes") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 73) (:start . 71)\n  (:id . 52))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 86) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.102) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102231@unknown@formal@none@1@S@(A) Wild-type larva, (B) adgf-a single mutant, (C) adoR adgf-a double mutant (scale bar, 0.5 mm).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "Wild-type") (:end . 13)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 19) (:start . 14)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 22) (:start . 21)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 23) (:start . 22)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 24) (:start . 23)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 31)\n  (:start . 25) (:id . 51))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 38)\n  (:start . 32) (:id . 52))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 45)\n  (:start . 39) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 48) (:start . 47)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 49) (:start . 48)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 50) (:start . 49)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 55) (:start . 51)\n  (:id . 58))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 62)\n  (:start . 56) (:id . 59))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 69)\n  (:start . 63) (:id . 60))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 76)\n  (:start . 70) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 62))\n ((:tag . "NN") (:stem . "scale") (:form . "scale") (:end . 83) (:start . 78)\n  (:id . 63))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 87) (:start . 84)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 65))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 92) (:start . 89)\n  (:id . 66))\n ((:tag . "NN") (:stem . "mm") (:form . "mm") (:end . 95) (:start . 93)\n  (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 96) (:start . 95)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.103) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102232@unknown@formal@none@1@S@The adgf-a Mutant Phenotype Is Rescued by Expression of ADGF-A in the Lymph Glands@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 17)\n  (:start . 11) (:id . 44))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "rescue") (:form . "Rescued") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Expression") (:form . "Expression") (:end . 52)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Lymph") (:form . "Lymph") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "NNPS") (:stem . "Glands") (:form . "Glands") (:end . 82)\n  (:start . 76) (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.104) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102233@unknown@formal@none@1@S@To distinguish which tissues require ADGF-A expression for proper development, we tested for rescue of adgf-a lethality by expressing ADGF-A in specific subsets of larval tissues.@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "distinguish") (:form . "distinguish") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 43)\n  (:start . 37) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "proper") (:form . "proper") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 77)\n  (:start . 66) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 88) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 109)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 119)\n  (:start . 110) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 133)\n  (:start . 123) (:id . 61))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 140)\n  (:start . 134) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 152)\n  (:start . 144) (:id . 64))\n ((:tag . "NNS") (:stem . "subset") (:form . "subsets") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 163) (:start . 161)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 170)\n  (:start . 164) (:id . 67))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 178)\n  (:start . 171) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x7.105.1) (:span 82 88)))\n (:hscopes ((:id . :x7.105.1) (:span 82 178)))\n (:identifiers (:sid . :s7.105) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102234@unknown@formal@none@1@S@A transgenic line carrying the UAS-ADGF-A construct on Chromosome II was crossed to lines expressing the Gal4 driver [18] in different tissues (Table 1).@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 12)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 26)\n  (:start . 18) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "UAS-ADGF-A") (:form . "UAS-ADGF-A") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 51)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 65)\n  (:start . 55) (:id . 50))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 68) (:start . 66)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 72) (:start . 69)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "cross") (:form . "crossed") (:end . 80)\n  (:start . 73) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 89) (:start . 84)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 100)\n  (:start . 90) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gal4") (:form . "Gal4") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 120) (:start . 118)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 121) (:start . 120)\n  (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 134)\n  (:start . 125) (:id . 64))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 149)\n  (:start . 144) (:id . 67))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 151) (:start . 150)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 152) (:start . 151)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s7.106) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102235@unknown@formal@none@1@S@Since ADGF-A is normally expressed in the larval lymph glands [16], and the mutant phenotype is characterized by abnormal hemocyte development, special consideration was given to lines expressing the Gal4 driver in the lymph glands and/or circulating hemocytes.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 82)\n  (:start . 76) (:id . 58))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 92)\n  (:start . 83) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 109) (:start . 96) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 112) (:start . 110)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 121)\n  (:start . 113) (:id . 63))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 142)\n  (:start . 131) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "special") (:form . "special") (:end . 151)\n  (:start . 144) (:id . 67))\n ((:tag . "NN") (:stem . "consideration") (:form . "consideration")\n  (:end . 165) (:start . 152) (:id . 68))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 169) (:start . 166)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "give") (:form . "given") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 195)\n  (:start . 185) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 199) (:start . 196)\n  (:id . 74))\n ((:tag . "NN") (:stem . "gal4") (:form . "Gal4") (:end . 204) (:start . 200)\n  (:id . 75))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 211)\n  (:start . 205) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 218) (:start . 215)\n  (:id . 78))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 224)\n  (:start . 219) (:id . 79))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 231)\n  (:start . 225) (:id . 80))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 238)\n  (:start . 232) (:id . 81))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 250)\n  (:start . 239) (:id . 82))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 260)\n  (:start . 251) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 261) (:start . 260)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s7.107) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102236@unknown@formal@none@1@S@No line expressing the Gal4 driver exclusively in the lymph glands has been reported, so we used a combination of lines sharing in common the feature of Gal4 driver expression in the lymph glands.@(((:tag . "DT") (:stem . "no") (:form . "No") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gal4") (:form . "Gal4") (:end . 27) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 34)\n  (:start . 28) (:id . 47))\n ((:tag . "RB") (:stem . "exclusively") (:form . "exclusively") (:end . 46)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 75) (:start . 71)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "report") (:form . "reported") (:end . 84)\n  (:start . 76) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "IN") (:stem . "so") (:form . "so") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 96) (:start . 92)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 110)\n  (:start . 99) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "line") (:form . "lines") (:end . 119)\n  (:start . 114) (:id . 63))\n ((:tag . "VBG") (:stem . "share") (:form . "sharing") (:end . 127)\n  (:start . 120) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 137)\n  (:start . 131) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 141) (:start . 138)\n  (:id . 67))\n ((:tag . "NN") (:stem . "feature") (:form . "feature") (:end . 149)\n  (:start . 142) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "gal4") (:form . "Gal4") (:end . 157) (:start . 153)\n  (:id . 70))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 164)\n  (:start . 158) (:id . 71))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 175)\n  (:start . 165) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 74))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 188)\n  (:start . 183) (:id . 75))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 195)\n  (:start . 189) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x7.108.1) (:span 0 2)))\n (:nscopes ((:id . :x7.108.1) (:span 0 84)))\n (:identifiers (:sid . :s7.108) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102237@unknown@formal@none@1@S@The results (see Figure 2 and Table 1) clearly demonstrate that expression of ADGF-A in the lymph glands (driven by Cg-Gal4,e33C-Gal4, or c564-Gal4), but not in any other tissue examined, is necessary and sufficient to fully rescue the adgf-a lethality.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 25) (:start . 24)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 37) (:start . 36)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 38) (:start . 37)\n  (:id . 51))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 46)\n  (:start . 39) (:id . 52))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 58)\n  (:start . 47) (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 74)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 84)\n  (:start . 78) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 97) (:start . 92)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 104)\n  (:start . 98) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 112)\n  (:start . 106) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "Cg-Gal4,e33C-Gal4") (:form . "Cg-Gal4,e33C-Gal4")\n  (:end . 133) (:start . 116) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 137) (:start . 135)\n  (:id . 67))\n ((:tag . "NN") (:stem . "c564-gal4") (:form . "c564-Gal4") (:end . 147)\n  (:start . 138) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 148) (:start . 147)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 153) (:start . 150)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 157) (:start . 154)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 73))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 164) (:start . 161)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 170)\n  (:start . 165) (:id . 75))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 177)\n  (:start . 171) (:id . 76))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 186)\n  (:start . 178) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 187) (:start . 186)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 190) (:start . 188)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 200)\n  (:start . 191) (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 204) (:start . 201)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 215)\n  (:start . 205) (:id . 82))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 218) (:start . 216)\n  (:id . 83))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 224)\n  (:start . 219) (:id . 84))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 231)\n  (:start . 225) (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 235) (:start . 232)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 242)\n  (:start . 236) (:id . 87))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 252)\n  (:start . 243) (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 253) (:start . 252)\n  (:id . 89)))@@@1@48@((:ncues ((:id . :x7.109.1) (:span 154 157)))\n (:nscopes ((:id . :x7.109.1) (:span 154 186)))\n (:identifiers (:sid . :s7.109) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102238@unknown@formal@none@1@S@In e33C-Gal4/UAS-ADGF-A, strong expression of ADGF-A in all lobes of developing lymph glands (but not in circulating hemocytes) reduces the number of hemocytes in the hemolymph to almost normal levels (see Figure 3).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "e33c-gal4/uas-adgf-a")\n  (:form . "e33C-Gal4/UAS-ADGF-A") (:end . 23) (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 52)\n  (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lobe") (:form . "lobes") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 85) (:start . 80)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 92)\n  (:start . 86) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 94) (:start . 93)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 116)\n  (:start . 105) (:id . 60))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 126)\n  (:start . 117) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 135)\n  (:start . 128) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 146)\n  (:start . 140) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 159)\n  (:start . 150) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 162) (:start . 160)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 166) (:start . 163)\n  (:id . 69))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 186)\n  (:start . 180) (:id . 72))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 193)\n  (:start . 187) (:id . 73))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 200)\n  (:start . 194) (:id . 74))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 202) (:start . 201)\n  (:id . 75))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 205) (:start . 202)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 212)\n  (:start . 206) (:id . 77))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 214) (:start . 213)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 215) (:start . 214)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 216) (:start . 215)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s7.110) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102240@unknown@formal@none@1@S@However, when assayed by survival rate and melanotic tumor formation, the rescue by Cg-Gal4 is full and similar to that of e33C-Gal4 (see Figure 2).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 38) (:start . 34)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cg-gal4") (:form . "Cg-Gal4") (:end . 91)\n  (:start . 84) (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 64))\n ((:tag . "NN") (:stem . "e33c-gal4") (:form . "e33C-Gal4") (:end . 132)\n  (:start . 123) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 134) (:start . 133)\n  (:id . 66))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 137) (:start . 134)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 144)\n  (:start . 138) (:id . 68))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 146) (:start . 145)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s7.112) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102241@unknown@formal@none@1@S@The difference in effectiveness may be explained by the different expression patterns of the drivers.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "effectiveness") (:form . "effectiveness")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "explain") (:form . "explained") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "NNS") (:stem . "pattern") (:form . "patterns") (:end . 85)\n  (:start . 77) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "driver") (:form . "drivers") (:end . 100)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 101) (:start . 100)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x7.113.1) (:span 32 35)))\n (:hscopes ((:id . :x7.113.1) (:span 0 100)))\n (:identifiers (:sid . :s7.113) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102242@unknown@formal@none@1@S@Cg-Gal4 is expressed only in certain compartments of lymph gland lobes containing relatively mature hemocytes, and strongly in most circulating hemocytes [22, 23].@(((:tag . "NNP") (:stem . "Cg-Gal4") (:form . "Cg-Gal4") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 36)\n  (:start . 29) (:id . 47))\n ((:tag . "NNS") (:stem . "compartment") (:form . "compartments") (:end . 49)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 58) (:start . 53)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 64) (:start . 59)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "lobe") (:form . "lobes") (:end . 70) (:start . 65)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 81)\n  (:start . 71) (:id . 53))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 92)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 99)\n  (:start . 93) (:id . 55))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 109)\n  (:start . 100) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 123)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 131) (:start . 127)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 143)\n  (:start . 132) (:id . 62))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 153)\n  (:start . 144) (:id . 63))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 155) (:start . 154)\n  (:id . 64))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 157) (:start . 155)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 158) (:start . 157)\n  (:id . 66))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 161) (:start . 159)\n  (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 162) (:start . 161)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.114) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102243@unknown@formal@none@1@S@The C564-Gal4 driver is not expressed as strongly as e33C-Gal4, but is still uniformly expressed in the lymph glands; it also fully rescued the mutant phenotype.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "c564-gal4") (:form . "C564-Gal4") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 49)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NN") (:stem . "e33c-gal4") (:form . "e33C-Gal4") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "RB") (:stem . "uniformly") (:form . "uniformly") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 116)\n  (:start . 110) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 120) (:start . 118)\n  (:id . 63))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 125) (:start . 121)\n  (:id . 64))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 139)\n  (:start . 132) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 150)\n  (:start . 144) (:id . 68))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 160)\n  (:start . 151) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 70)))@@@1@29@((:ncues ((:id . :x7.115.1) (:span 24 27)))\n (:nscopes ((:id . :x7.115.1) (:span 24 62)))\n (:identifiers (:sid . :s7.115) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102244@unknown@formal@none@1@S@We have tried two different insertions of the Dot-Gal4 construct.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "try") (:form . "tried") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "NNS") (:stem . "insertion") (:form . "insertions") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "dot-gal4") (:form . "Dot-Gal4") (:end . 54)\n  (:start . 46) (:id . 50))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 65) (:start . 64)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s7.116) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102245@unknown@formal@none@1@S@The Dot-Gal411C on Chromosome II, which shows weak expression [24], did not rescue the phenotype, but a Dot-Gal443A insertion on Chromosome X, which shows stronger expression, rescued approximately half of the mutant animals (Figure 2).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Dot-Gal411C") (:form . "Dot-Gal411C") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 63) (:start . 62)\n  (:id . 52))\n ((:tag . "CD") (:stem . "24") (:form . "24") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 71) (:start . 68)\n  (:id . 56))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 75) (:start . 72)\n  (:id . 57))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 82)\n  (:start . 76) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 96)\n  (:start . 87) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 101) (:start . 98)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 103) (:start . 102)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Dot-Gal443A") (:form . "Dot-Gal443A") (:end . 115)\n  (:start . 104) (:id . 64))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 125)\n  (:start . 116) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 128) (:start . 126)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 139)\n  (:start . 129) (:id . 67))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 141) (:start . 140)\n  (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 142) (:start . 141)\n  (:id . 69))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 148)\n  (:start . 143) (:id . 70))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 154)\n  (:start . 149) (:id . 71))\n ((:tag . "JJR") (:stem . "strong") (:form . "stronger") (:end . 163)\n  (:start . 155) (:id . 72))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 174)\n  (:start . 164) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 175) (:start . 174)\n  (:id . 74))\n ((:tag . "VBD") (:stem . "rescue") (:form . "rescued") (:end . 183)\n  (:start . 176) (:id . 75))\n ((:tag . "RB") (:stem . "approximately") (:form . "approximately")\n  (:end . 197) (:start . 184) (:id . 76))\n ((:tag . "NN") (:stem . "half") (:form . "half") (:end . 202) (:start . 198)\n  (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 205) (:start . 203)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 216)\n  (:start . 210) (:id . 80))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 224)\n  (:start . 217) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 226) (:start . 225)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 232)\n  (:start . 226) (:id . 83))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 234) (:start . 233)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 235) (:start . 234)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 236) (:start . 235)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x7.117.1) (:span 72 75)))\n (:nscopes ((:id . :x7.117.1) (:span 72 96)))\n (:identifiers (:sid . :s7.117) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102246@unknown@formal@none@1@S@Nearly all rescued individuals were males, suggesting that expression of the Gal4 driver was influenced by X-chromosome dosage compensation, and expression in females heterozygous for Dot-Gal4 was not strong enough for rescue.@(((:tag . "RB") (:stem . "nearly") (:form . "Nearly") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "NNS") (:stem . "individual") (:form . "individuals") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "gal4") (:form . "Gal4") (:end . 81) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "influence") (:form . "influenced") (:end . 103)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "x-chromosome") (:form . "X-chromosome") (:end . 119)\n  (:start . 107) (:id . 59))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 126)\n  (:start . 120) (:id . 60))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 139)\n  (:start . 127) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 63))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 155)\n  (:start . 145) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 166)\n  (:start . 159) (:id . 66))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 179)\n  (:start . 167) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 183) (:start . 180)\n  (:id . 68))\n ((:tag . "NN") (:stem . "dot-gal4") (:form . "Dot-Gal4") (:end . 192)\n  (:start . 184) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 196) (:start . 193)\n  (:id . 70))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 207)\n  (:start . 201) (:id . 72))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 214)\n  (:start . 208) (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 218) (:start . 215)\n  (:id . 74))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 225)\n  (:start . 219) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x7.118.2) (:span 43 53)))\n (:ncues ((:id . :x7.118.1) (:span 197 200)))\n (:hscopes ((:id . :x7.118.2) (:span 43 179)))\n (:nscopes ((:id . :x7.118.1) (:span 184 225)))\n (:identifiers (:sid . :s7.118) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102247@unknown@formal@none@1@S@Expression of ADGF-A in salivary glands and fat body (as well as in other tissues) is not required for full rescue, as demonstrated by use of the Cg-Gal4,Dot-Gal4, but especially by e33C-Gal4 driver, and is also not sufficient to rescue the phenotype at all, as demonstrated by T110-Gal4 and Lsp2-Gal4 (Table 1).@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 39)\n  (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 61) (:start . 57)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 73) (:start . 68)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 81)\n  (:start . 74) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 85) (:start . 83)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 89) (:start . 86)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 98)\n  (:start . 90) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "full") (:form . "full") (:end . 107) (:start . 103)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 114)\n  (:start . 108) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 131)\n  (:start . 119) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 134) (:start . 132)\n  (:id . 68))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 138) (:start . 135)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 71))\n ((:tag . "NN") (:stem . "Cg-Gal4,Dot-Gal4") (:form . "Cg-Gal4,Dot-Gal4")\n  (:end . 162) (:start . 146) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 73))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 167) (:start . 164)\n  (:id . 74))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 178)\n  (:start . 168) (:id . 75))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 181) (:start . 179)\n  (:id . 76))\n ((:tag . "NN") (:stem . "e33c-gal4") (:form . "e33C-Gal4") (:end . 191)\n  (:start . 182) (:id . 77))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 198)\n  (:start . 192) (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 79))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 80))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 206) (:start . 204)\n  (:id . 81))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 211) (:start . 207)\n  (:id . 82))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 215) (:start . 212)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 226)\n  (:start . 216) (:id . 84))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 229) (:start . 227)\n  (:id . 85))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 236)\n  (:start . 230) (:id . 86))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 240) (:start . 237)\n  (:id . 87))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 250)\n  (:start . 241) (:id . 88))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 253) (:start . 251)\n  (:id . 89))\n ((:tag . "DT") (:stem . "all") (:form . 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"1") (:end . 310) (:start . 309)\n  (:id . 100))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 311) (:start . 310)\n  (:id . 101))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 312) (:start . 311)\n  (:id . 102)))@@@1@61@((:ncues ((:id . :x7.119.1) (:span 212 215))\n  ((:id . :x7.119.2) (:span 86 89)))\n (:nscopes ((:id . :x7.119.1) (:span 212 257))\n  ((:id . :x7.119.2) (:span 0 114)))\n (:identifiers (:sid . :s7.119) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102248@unknown@formal@none@1@S@Since ADGF-A is strongly expressed in embryonic mesoderm [16], we have tried to rescue the phenotype by the expression of ADGF-A in embryonic and larval muscle cells using the Dmef2-Gal4 driver [25].@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 12)\n  (:start . 6) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NN") (:stem . "mesoderm") (:form . "mesoderm") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 65) (:start . 63)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "try") (:form . "tried") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 100)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 62))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 118)\n  (:start . 108) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 128)\n  (:start . 122) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 131) (:start . 129)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "embryonic") (:form . "embryonic") (:end . 141)\n  (:start . 132) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 152)\n  (:start . 146) (:id . 69))\n ((:tag . "NN") (:stem . "muscle") (:form . "muscle") (:end . 159)\n  (:start . 153) (:id . 70))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 165)\n  (:start . 160) (:id . 71))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 171) (:start . 166)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 175) (:start . 172)\n  (:id . 73))\n ((:tag . "NN") (:stem . "dmef2-gal4") (:form . "Dmef2-Gal4") (:end . 186)\n  (:start . 176) (:id . 74))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 193)\n  (:start . 187) (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 195) (:start . 194)\n  (:id . 76))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 197) (:start . 195)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 198) (:start . 197)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s7.120) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102250@unknown@formal@none@1@S@The only line showing significant (but not complete) rescue of adgf-a survival without expression in the lymph glands was GawB5015 (see Figure 2), which expresses the Gal4 driver very strongly and specifically in the ring gland and salivary glands (as well as very weak and spotty expression in imaginal discs [unpublished data]).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "CC") (:stem . "but") (:form . 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5102251@unknown@formal@none@1@S@However, expression of ADGF-A driven by GawB5015 does not prevent the formation of melanotic tumors (see Figure 2B).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "VBN") (:stem . "drive") (:form . "driven") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "GawB5015") (:form . "GawB5015") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VB") (:stem . "prevent") (:form . "prevent") (:end . 65)\n  (:start . 58) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 79)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 99)\n  (:start . 93) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 111)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "2b") (:form . "2B") (:end . 114) (:start . 112)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:ncues ((:id . :x7.123.1) (:span 54 57)))\n (:nscopes ((:id . :x7.123.1) (:span 54 99)))\n (:identifiers (:sid . :s7.123) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102252@unknown@formal@none@1@S@Ablation of Hemocytes in Mutant Larvae Reduces Fat Body Disintegration and Melanotic Tumor Formation@(((:tag . "NNP") (:stem . "Ablation") (:form . "Ablation") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocytes") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Mutant") (:form . "Mutant") (:end . 31)\n  (:start . 25) (:id . 46))\n ((:tag . "NNP") (:stem . "Larvae") (:form . "Larvae") (:end . 38)\n  (:start . 32) (:id . 47))\n ((:tag . "NNP") (:stem . "Reduces") (:form . "Reduces") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "NNP") (:stem . "Fat") (:form . "Fat") (:end . 50) (:start . 47)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Body") (:form . "Body") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Disintegration") (:form . "Disintegration")\n  (:end . 70) (:start . 56) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Melanotic") (:form . "Melanotic") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "NNP") (:stem . "Tumor") (:form . "Tumor") (:end . 90) (:start . 85)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Formation") (:form . "Formation") (:end . 100)\n  (:start . 91) (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.124) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102253@unknown@formal@none@1@S@The l(3)hematopoiesis missing(l[3]hem) mutation reduces cell division in larval proliferating tissues and thus dramatically reduces the number of hemocytes in larvae.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "l(3)hematopoiesis") (:form . "l(3)hematopoiesis")\n  (:end . 21) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "missing(l[3]hem)") (:form . "missing(l[3]hem)")\n  (:end . 38) (:start . 22) (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 47)\n  (:start . 39) (:id . 45))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 55)\n  (:start . 48) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 60) (:start . 56)\n  (:id . 47))\n ((:tag . "NN") (:stem . "division") (:form . "division") (:end . 69)\n  (:start . 61) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 72) (:start . 70)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 79)\n  (:start . 73) (:id . 50))\n ((:tag . "VBG") (:stem . "proliferate") (:form . "proliferating") (:end . 93)\n  (:start . 80) (:id . 51))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 101)\n  (:start . 94) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 53))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 110) (:start . 106)\n  (:id . 54))\n ((:tag . "RB") (:stem . "dramatically") (:form . "dramatically") (:end . 123)\n  (:start . 111) (:id . 55))\n ((:tag . "VBZ") (:stem . "reduce") (:form . "reduces") (:end . 131)\n  (:start . 124) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 135) (:start . 132)\n  (:id . 57))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 142)\n  (:start . 136) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 155)\n  (:start . 146) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 158) (:start . 156)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 165)\n  (:start . 159) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.125) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102254@unknown@formal@none@1@S@It also suppresses the hemocyte overproliferation and associated defects observed in the hopscotchTumorous-lethal mutant [26].@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "overproliferation") (:form . "overproliferation")\n  (:end . 49) (:start . 32) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 53) (:start . 50)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "NNS") (:stem . "defect") (:form . "defects") (:end . 72)\n  (:start . 65) (:id . 50))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "hopscotchtumorous-lethal")\n  (:form . "hopscotchTumorous-lethal") (:end . 113) (:start . 89) (:id . 54))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 120)\n  (:start . 114) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 122) (:start . 121)\n  (:id . 56))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 124) (:start . 122)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 125) (:start . 124)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.126) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102255@unknown@formal@none@1@S@We therefore used the l(3)hem1 mutation to test whether the reduction of hemocyte number in the adgf-a mutant affects the phenotype.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "l(3)hem1") (:form . "l(3)hem1") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 69)\n  (:start . 60) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 81)\n  (:start . 73) (:id . 54))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 102)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 109)\n  (:start . 103) (:id . 59))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 131)\n  (:start . 122) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 132) (:start . 131)\n  (:id . 63)))@@@1@22@((:hcues ((:id . :x7.127.1) (:span 48 55)))\n (:hscopes ((:id . :x7.127.1) (:span 48 131)))\n (:identifiers (:sid . :s7.127) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102256@unknown@formal@none@1@S@We recombined this mutation onto the chromosome containing the adgf-a mutation and found that in homozygous l(3)hem1,adgf-a double mutants the number of hemocytes is significantly reduced compared to the adgf-a single mutants (see Figure 3).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "recombine") (:form . "recombined") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "onto") (:form . "onto") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 47)\n  (:start . 37) (:id . 48))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 58)\n  (:start . 48) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 69)\n  (:start . 63) (:id . 51))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 78)\n  (:start . 70) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 82) (:start . 79)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 88) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 107)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "l(3)hem1,adgf-a") (:form . "l(3)hem1,adgf-a")\n  (:end . 123) (:start . 108) (:id . 58))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 130)\n  (:start . 124) (:id . 59))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 138)\n  (:start . 131) (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 142) (:start . 139)\n  (:id . 61))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 149)\n  (:start . 143) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 152) (:start . 150)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 162)\n  (:start . 153) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 165) (:start . 163)\n  (:id . 65))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 179) (:start . 166) (:id . 66))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 187)\n  (:start . 180) (:id . 67))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 196)\n  (:start . 188) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 199) (:start . 197)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 210)\n  (:start . 204) (:id . 71))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 217)\n  (:start . 211) (:id . 72))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 225)\n  (:start . 218) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 74))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 230) (:start . 227)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 237)\n  (:start . 231) (:id . 76))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 239) (:start . 238)\n  (:id . 77))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 240) (:start . 239)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 241) (:start . 240)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s7.128) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102257@unknown@formal@none@1@S@Furthermore, while 90% of adgf-a mutant larvae showed disintegration of fat body, only 40% of l(3)hem1,adgf-a double mutants (total number of counted animals was 82) show the disintegration (Figure 6A).@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "90") (:form . "90") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 46)\n  (:start . 40) (:id . 50))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 53) (:start . 47)\n  (:id . 51))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 68) (:start . 54) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 86) (:start . 82)\n  (:id . 57))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 90) (:start . 89)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "l(3)hem1,adgf-a") (:form . "l(3)hem1,adgf-a")\n  (:end . 109) (:start . 94) (:id . 61))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 116)\n  (:start . 110) (:id . 62))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 126) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "total") (:form . "total") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 138)\n  (:start . 132) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "count") (:form . "counted") (:end . 149)\n  (:start . 142) (:id . 68))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 157)\n  (:start . 150) (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 161) (:start . 158)\n  (:id . 70))\n ((:tag . "CD") (:stem . "82") (:form . "82") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 170) (:start . 166)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 189) (:start . 175) (:id . 75))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 191) (:start . 190)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 197)\n  (:start . 191) (:id . 77))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 200) (:start . 198)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 201) (:start . 200)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 202) (:start . 201)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s7.129) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102258@unknown@formal@none@1@S@Similarly, melanotic tumor formation is significantly suppressed by l(3)hem1, with only 55% of double mutants showing melanotic tumors compared to more than 83% in adgf-a (Figure 6A).@(((:tag . "RB") (:stem . "similarly") (:form . "Similarly") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 53) (:start . 40) (:id . 48))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 64)\n  (:start . 54) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 67) (:start . 65)\n  (:id . 50))\n ((:tag . "CD") (:stem . "l(3)hem1") (:form . "l(3)hem1") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 82) (:start . 78)\n  (:id . 53))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 87) (:start . 83)\n  (:id . 54))\n ((:tag . "CD") (:stem . "55") (:form . "55") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 101)\n  (:start . 95) (:id . 58))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 134)\n  (:start . 128) (:id . 62))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 143)\n  (:start . 135) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 146) (:start . 144)\n  (:id . 64))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 151) (:start . 147)\n  (:id . 65))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 156) (:start . 152)\n  (:id . 66))\n ((:tag . "CD") (:stem . "83") (:form . "83") (:end . 159) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 160) (:start . 159)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 163) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 170)\n  (:start . 164) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 172) (:start . 171)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 178)\n  (:start . 172) (:id . 72))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 181) (:start . 179)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s7.130) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102260@unknown@formal@none@1@S@This shows that the effect on hemocyte development is related to only one other aspect of the adgf-a phenotype—namely, fat body disintegration—and the developmental arrest of adgf-a mutants is probably independent of this process.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 38)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 50)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 69) (:start . 65)\n  (:id . 53))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 79) (:start . 74)\n  (:id . 55))\n ((:tag . "NN") (:stem . "aspect") (:form . "aspect") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 58))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 110)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "—") (:form . "—") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 117)\n  (:start . 111) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 127) (:start . 123)\n  (:id . 65))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 142) (:start . 128) (:id . 66))\n ((:tag . "NN") (:stem . "—") (:form . "—") (:end . 143) (:start . 142)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 164) (:start . 151) (:id . 70))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 171)\n  (:start . 165) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 174) (:start . 172)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 181)\n  (:start . 175) (:id . 73))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 189)\n  (:start . 182) (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 192) (:start . 190)\n  (:id . 75))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 201)\n  (:start . 193) (:id . 76))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 213)\n  (:start . 202) (:id . 77))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 78))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 221) (:start . 217)\n  (:id . 79))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 229)\n  (:start . 222) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 230) (:start . 229)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s7.132) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102261@unknown@formal@none@1@S@   Suppression of the adgf-a Mutant Phenotype by Mutations in Other Genes@(((:tag . "NN") (:stem . "suppression") (:form . "Suppression") (:end . 14)\n  (:start . 3) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "Phenotype") (:form . "Phenotype") (:end . 45)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mutation") (:form . "Mutations") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "Genes") (:end . 73) (:start . 68)\n  (:id . 52)))@@@1@11@((:identifiers (:sid . :s7.133) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102262@unknown@formal@none@1@S@(A) Percentage of late third-instar larvae with melanotic tumors (black bars) and fat body disintegration (green bars).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NN") (:stem . "percentage") (:form . "Percentage") (:end . 14)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 35)\n  (:start . 23) (:id . 48))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 57)\n  (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 64)\n  (:start . 58) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "black") (:form . "black") (:end . 71) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 77) (:start . 76)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 85) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 90) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 105) (:start . 91) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "green") (:form . "green") (:end . 112)\n  (:start . 107) (:id . 62))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.134) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102263@unknown@formal@none@1@S@The x-axis (which is shared with [B]), shows the genotype.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 27)\n  (:start . 21) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 35) (:start . 34)\n  (:id . 50))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 36) (:start . 35)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 37) (:start . 36)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 44) (:start . 39)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 55))\n ((:tag . "NN") (:stem . "genotype") (:form . "genotype") (:end . 57)\n  (:start . 49) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s7.135) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102264@unknown@formal@none@1@S@The y-axis shows the percentage of larvae with tumors and fat body disintegration.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 41)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "tumor") (:form . "tumors") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 81) (:start . 67) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.136) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102265@unknown@formal@none@1@S@(B) Survival rate of double mutants compared to single adgf-a mutant.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "Survival") (:form . "Survival") (:end . 12)\n  (:start . 4) (:id . 45))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 27)\n  (:start . 21) (:id . 48))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 35)\n  (:start . 28) (:id . 49))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 44)\n  (:start . 36) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 47) (:start . 45)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 61)\n  (:start . 55) (:id . 53))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 68)\n  (:start . 62) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 69) (:start . 68)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.137) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102266@unknown@formal@none@1@S@The y-axis shows the percentage of the pupae (blue bars) and adult flies (purple bars) demonstrating the larval and pupal survival, respectively.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pupae") (:form . "pupae") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 55) (:start . 51)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 66) (:start . 61)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 74) (:start . 73)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "purple") (:form . "purple") (:end . 80)\n  (:start . 74) (:id . 58))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 85) (:start . 81)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 100) (:start . 87) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 111)\n  (:start . 105) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 121)\n  (:start . 116) (:id . 65))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 130)\n  (:start . 122) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 67))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 144)\n  (:start . 132) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.138) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102267@unknown@formal@none@1@S@Each experiment was repeated at least four times (with 20–30 animals in each vial) and the standard error is shown.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "experiment") (:form . "experiment") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "repeat") (:form . "repeated") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "time") (:form . "times") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 50))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "CD") (:stem . "20–30") (:form . "20–30") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 68)\n  (:start . 61) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "vial") (:form . "vial") (:end . 81) (:start . 77)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 105)\n  (:start . 100) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 114)\n  (:start . 109) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.139) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102268@unknown@formal@none@1@S@Block in Activation of Macrophages Suppresses Disintegration of Fat Body@(((:tag . "NNP") (:stem . "Block") (:form . "Block") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Activation") (:form . "Activation") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Macrophage") (:form . "Macrophages") (:end . 34)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "Suppresses") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "NNP") (:stem . "Disintegration") (:form . "Disintegration")\n  (:end . 60) (:start . 46) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Fat") (:form . "Fat") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Body") (:form . "Body") (:end . 72) (:start . 68)\n  (:id . 51)))@@@1@10@((:identifiers (:sid . :s7.140) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102270@unknown@formal@none@1@S@Embryonic macrophages express the scavenger receptor encoded by croquemort(crq), which allows them to bind and remove apoptotic corpses [27].@(((:tag . "JJ") (:stem . "embryonic") (:form . "Embryonic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 21)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 29)\n  (:start . 22) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 45))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 43)\n  (:start . 34) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 52)\n  (:start . 44) (:id . 47))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 60)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 63) (:start . 61)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "croquemort(crq)") (:form . "croquemort(crq)")\n  (:end . 79) (:start . 64) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 80) (:start . 79)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 86) (:start . 81)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "allow") (:form . "allows") (:end . 93)\n  (:start . 87) (:id . 53))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 98) (:start . 94)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 101) (:start . 99)\n  (:id . 55))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 106) (:start . 102)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 110) (:start . 107)\n  (:id . 57))\n ((:tag . "VB") (:stem . "remove") (:form . "remove") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 127)\n  (:start . 118) (:id . 59))\n ((:tag . "NNS") (:stem . "corpse") (:form . "corpses") (:end . 135)\n  (:start . 128) (:id . 60))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 139) (:start . 137)\n  (:id . 62))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.142) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102271@unknown@formal@none@1@S@We therefore tested whether a mutation in the crq gene would block the suggested interaction between hemocytes and fat body in adgf-a mutant larvae.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 19) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 27)\n  (:start . 20) (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 38)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "crq") (:form . "crq") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 54) (:start . 50)\n  (:id . 51))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 92)\n  (:start . 81) (:id . 56))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 110)\n  (:start . 101) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 118) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 123) (:start . 119)\n  (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 133)\n  (:start . 127) (:id . 63))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x7.143.1) (:span 71 80)) ((:id . :x7.143.2) (:span 55 60))\n  ((:id . :x7.143.3) (:span 20 27)))\n (:hscopes ((:id . :x7.143.1) (:span 71 123))\n  ((:id . :x7.143.2) (:span 28 147)) ((:id . :x7.143.3) (:span 20 147)))\n (:identifiers (:sid . :s7.143) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102272@unknown@formal@none@1@S@We used the mutation crqKG01679, caused by a P-element insertion in the first untranslated exon of crq, which leads to pupal lethality.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "crqkg01679") (:form . "crqKG01679") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 44) (:start . 43)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 77) (:start . 72)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "untranslated") (:form . "untranslated") (:end . 90)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "exon") (:form . "exon") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "crq") (:form . "crq") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 60))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 115)\n  (:start . 110) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 118) (:start . 116)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 124)\n  (:start . 119) (:id . 64))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 134)\n  (:start . 125) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.144) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102273@unknown@formal@none@1@S@The number of crystal cells was not increased and lamellocytes were not detected in crq, adgf-a double mutants (see Figure 3).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "crystal") (:form . "crystal") (:end . 21)\n  (:start . 14) (:id . 45))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 45)\n  (:start . 36) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "lamellocyte") (:form . "lamellocytes") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "crq") (:form . "crq") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 95)\n  (:start . 89) (:id . 58))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 102)\n  (:start . 96) (:id . 59))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 112) (:start . 111)\n  (:id . 61))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 115) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 122)\n  (:start . 116) (:id . 63))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 66)))@@@1@25@((:ncues ((:id . :x7.145.1) (:span 68 71)) ((:id . :x7.145.2) (:span 32 35)))\n (:nscopes ((:id . :x7.145.1) (:span 50 110))\n  ((:id . :x7.145.2) (:span 0 45)))\n (:identifiers (:sid . :s7.145) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102274@unknown@formal@none@1@S@The double mutants showed a lower number of circulating hemocytes than the single mutant, but there was still a significant increase in this number compared to wild type (see Figure 3), and the cells showed increased clumping.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 25) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 46))\n ((:tag . "JJR") (:stem . "low") (:form . "lower") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 55)\n  (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 81)\n  (:start . 75) (:id . 54))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 93) (:start . 90)\n  (:id . 57))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 123)\n  (:start . 112) (:id . 62))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 132)\n  (:start . 124) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 147)\n  (:start . 141) (:id . 66))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 156)\n  (:start . 148) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 71))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 174) (:start . 171)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 181)\n  (:start . 175) (:id . 73))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 183) (:start . 182)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 184) (:start . 183)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 193) (:start . 190)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 199)\n  (:start . 194) (:id . 79))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 206)\n  (:start . 200) (:id . 80))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 216)\n  (:start . 207) (:id . 81))\n ((:tag . "NN") (:stem . "clumping") (:form . "clumping") (:end . 225)\n  (:start . 217) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 226) (:start . 225)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s7.146) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102275@unknown@formal@none@1@S@None of the double-mutant larvae showed either disintegration of fat body or melanotic tumor formation (Figure 6A).@(((:tag . "NN") (:stem . "none") (:form . "None") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "double-mutant") (:form . "double-mutant")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "larvae") (:form . "larvae") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 39) (:start . 33)\n  (:id . 47))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 46)\n  (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 61) (:start . 47) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 68) (:start . 65)\n  (:id . 51))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 73) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 76) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 86)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 92) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 104) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:ncues ((:id . :x7.147.1) (:span 0 4)))\n (:nscopes ((:id . :x7.147.1) (:span 0 102)))\n (:identifiers (:sid . :s7.147) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102276@unknown@formal@none@1@S@Even the adgf-a mutant larvae heterozygous for the crq mutation (crq/CyO GFP; adgf-a/adgf-a) showed significant suppression of the fat body disintegration, with most of the tissue staying compact in bigger pieces and never disintegrating to single adipose cells; melanotic tumors were rarely observed.@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 42)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . 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"observed") (:end . 300)\n  (:start . 292) (:id . 89))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 301) (:start . 300)\n  (:id . 90)))@@@1@49@((:ncues ((:id . :x7.148.1) (:span 217 222)))\n (:nscopes ((:id . :x7.148.1) (:span 217 261)))\n (:identifiers (:sid . :s7.148) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102277@unknown@formal@none@1@S@This shows that the block of the putative interaction between fat body and macrophage-like cells (which are still present in double mutants) suppresses the fat body disintegration, further strengthening the hypothesis that the disintegration is caused by hemocytes.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 41)\n  (:start . 33) (:id . 49))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 53)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 65) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 90) (:start . 75) (:id . 55))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 103)\n  (:start . 98) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 113)\n  (:start . 108) (:id . 60))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 121)\n  (:start . 114) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 131)\n  (:start . 125) (:id . 63))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 139)\n  (:start . 132) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "suppress") (:form . "suppresses") (:end . 151)\n  (:start . 141) (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 159) (:start . 156)\n  (:id . 68))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 164) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 179) (:start . 165) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 188)\n  (:start . 181) (:id . 72))\n ((:tag . "VBG") (:stem . "strengthen") (:form . "strengthening") (:end . 202)\n  (:start . 189) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 206) (:start . 203)\n  (:id . 74))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 217)\n  (:start . 207) (:id . 75))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 222) (:start . 218)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 77))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 241) (:start . 227) (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 244) (:start . 242)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 251)\n  (:start . 245) (:id . 80))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 254) (:start . 252)\n  (:id . 81))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 264)\n  (:start . 255) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 265) (:start . 264)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x7.149.1) (:span 207 217))\n  ((:id . :x7.149.2) (:span 33 41)))\n (:hscopes ((:id . :x7.149.1) (:span 207 264))\n  ((:id . :x7.149.2) (:span 33 140)))\n (:identifiers (:sid . :s7.149) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102278@unknown@formal@none@1@S@In addition, the absence of lamellocytes and the normal number of crystal cells in the double mutant strongly suggest that the differentiation of these cells and thus melanotic tumor formation is a secondary reaction to fat body disintegration, rather than a primary effect of the adgf-a mutation.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 45))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "lamellocyte") (:form . "lamellocytes") (:end . 40)\n  (:start . 28) (:id . 48))\n ((:tag . 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"mutant") (:end . 100)\n  (:start . 94) (:id . 59))\n ((:tag . "RB") (:stem . "strongly") (:form . "strongly") (:end . 109)\n  (:start . 101) (:id . 60))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 122) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 142) (:start . 127) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 151)\n  (:start . 146) (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 176)\n  (:start . 167) (:id . 70))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 182)\n  (:start . 177) (:id . 71))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 192)\n  (:start . 183) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 195) (:start . 193)\n  (:id . 73))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 197) (:start . 196)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "secondary") (:form . "secondary") (:end . 207)\n  (:start . 198) (:id . 75))\n ((:tag . "NN") (:stem . "reaction") (:form . "reaction") (:end . 216)\n  (:start . 208) (:id . 76))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 219) (:start . 217)\n  (:id . 77))\n ((:tag . "VB") (:stem . "fat") (:form . "fat") (:end . 223) (:start . 220)\n  (:id . 78))\n ((:tag . "NN") (:stem . "body") (:form . 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"adgf-a") (:end . 287)\n  (:start . 281) (:id . 89))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 296)\n  (:start . 288) (:id . 90))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 297) (:start . 296)\n  (:id . 91)))@@@1@50@((:hcues ((:id . :x7.150.2) (:span 110 117)))\n (:ncues ((:id . :x7.150.1) (:span 245 256)))\n (:hscopes ((:id . :x7.150.2) (:span 110 296)))\n (:nscopes ((:id . :x7.150.1) (:span 245 296)))\n (:identifiers (:sid . :s7.150) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102280@unknown@formal@none@1@S@We have identified a putative homolog of the mammalian adenosine receptor family in the Drosophila genome, AdoR, and produced a null mutation in this gene using homologous recombination (adoR; ED, unpublished data).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 18)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 20) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 80)\n  (:start . 74) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 98)\n  (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 105)\n  (:start . 99) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "AdoR") (:form . "AdoR") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 112) (:start . 111)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 144) (:start . 142)\n  (:id . 66))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 149) (:start . 145)\n  (:id . 67))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 160) (:start . 155)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 171)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "recombination") (:form . "recombination")\n  (:end . 185) (:start . 172) (:id . 71))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 187) (:start . 186)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 191) (:start . 187)\n  (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 192) (:start . 191)\n  (:id . 74))\n ((:tag . "VBN") (:stem . "ed") (:form . "ED") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 208)\n  (:start . 197) (:id . 77))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 213)\n  (:start . 209) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 214) (:start . 213)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s7.152) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102281@unknown@formal@none@1@S@The adoR mutants are fully viable.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "viable") (:form . "viable") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 34) (:start . 33)\n  (:id . 48)))@@@1@7@((:identifiers (:sid . :s7.153) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102282@unknown@formal@none@1@S@We used this mutant to test the hypothesis that the increased level of adenosine in the adgf-a mutant contributes to the mutant phenotype by its effect on signaling through the adenosine receptor.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 42)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 61)\n  (:start . 52) (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 67) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "VBZ") (:stem . "contribute") (:form . "contributes") (:end . 113)\n  (:start . 102) (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 120) (:start . 117)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 127)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 137)\n  (:start . 128) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 144) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 151)\n  (:start . 145) (:id . 67))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 154) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 164)\n  (:start . 155) (:id . 69))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 172)\n  (:start . 165) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 71))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 186)\n  (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 195)\n  (:start . 187) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x7.154.1) (:span 32 42)))\n (:hscopes ((:id . :x7.154.1) (:span 32 195)))\n (:identifiers (:sid . :s7.154) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102283@unknown@formal@none@1@S@The results show that introducing the adoR mutation into the adgf-a background significantly increases pupariation, as well as adult emerging rate, compared to the adgf-a single mutant (Figure 6B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "introduce") (:form . "introducing") (:end . 33)\n  (:start . 22) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 51)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 67)\n  (:start . 61) (:id . 52))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 78)\n  (:start . 68) (:id . 53))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 92) (:start . 79) (:id . 54))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 102)\n  (:start . 93) (:id . 55))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 114)\n  (:start . 103) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 57))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 118) (:start . 116)\n  (:id . 58))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 126) (:start . 124)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . "VBG") (:stem . "emerge") (:form . "emerging") (:end . 141)\n  (:start . 133) (:id . 62))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 146) (:start . 142)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 170)\n  (:start . 164) (:id . 68))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 177)\n  (:start . 171) (:id . 69))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 184)\n  (:start . 178) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 192)\n  (:start . 186) (:id . 72))\n ((:tag . "NN") (:stem . "6b") (:form . "6B") (:end . 195) (:start . 193)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s7.155) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102284@unknown@formal@none@1@S@When the earlier lethality was avoided by picking up larvae after molt to the third instar, the pupariation rate of adoR, adgf-a double mutant was comparable to wild type as well as to the single adgf-a mutant treated with ecdysone (Figure 7A).@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJR") (:stem . "early") (:form . "earlier") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "lethality") (:form . "lethality") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "avoid") (:form . "avoided") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "pick") (:form . "picking") (:end . 49)\n  (:start . 42) (:id . 49))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 52) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 59)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "molt") (:form . "molt") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 83) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 107)\n  (:start . 96) (:id . 60))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 112) (:start . 108)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 120) (:start . 116)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 128)\n  (:start . 122) (:id . 65))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 135)\n  (:start . 129) (:id . 66))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 142)\n  (:start . 136) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 146) (:start . 143)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "comparable") (:form . "comparable") (:end . 157)\n  (:start . 147) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "wild") (:form . "wild") (:end . 165) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "type") (:form . "type") (:end . 170) (:start . 166)\n  (:id . 72))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 173) (:start . 171)\n  (:id . 73))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 178) (:start . 174)\n  (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 181) (:start . 179)\n  (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 195)\n  (:start . 189) (:id . 78))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 202)\n  (:start . 196) (:id . 79))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 209)\n  (:start . 203) (:id . 80))\n ((:tag . "VBN") (:stem . "treat") (:form . "treated") (:end . 217)\n  (:start . 210) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 222) (:start . 218)\n  (:id . 82))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 231)\n  (:start . 223) (:id . 83))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 233) (:start . 232)\n  (:id . 84))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 239)\n  (:start . 233) (:id . 85))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 242) (:start . 240)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 243) (:start . 242)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 244) (:start . 243)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s7.156) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102285@unknown@formal@none@1@S@Development during the third instar is much less delayed in the double mutant, with most of the larvae pupariating within 1 d after their heterozygous siblings (Figure 7A).@(((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 18)\n  (:start . 12) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "third") (:form . "third") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "instar") (:form . "instar") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "RB") (:stem . "much") (:form . "much") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "RBR") (:stem . "less") (:form . "less") (:end . 48) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 56)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 70)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 83) (:start . 79)\n  (:id . 56))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 91) (:start . 89)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 102)\n  (:start . 96) (:id . 60))\n ((:tag . "VBG") (:stem . "pupariate") (:form . "pupariating") (:end . 114)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 121)\n  (:start . 115) (:id . 62))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 125) (:start . 124)\n  (:id . 64))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 150)\n  (:start . 138) (:id . 67))\n ((:tag . "NNS") (:stem . "sibling") (:form . "siblings") (:end . 159)\n  (:start . 151) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 69))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 167)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 170) (:start . 168)\n  (:id . 71))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 171) (:start . 170)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s7.157) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102286@unknown@formal@none@1@S@The adoR mutation also significantly reduced melanotic tumor formation in the adgf-a mutant (see Figure 6A), but disintegration of the fat body appeared at the same rate as in the single mutant (see Figure 6A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "adoR") (:form . "adoR") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 36) (:start . 23) (:id . 46))\n ((:tag . "VBD") (:stem . "reduce") (:form . "reduced") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 54)\n  (:start . 45) (:id . 48))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 60) (:start . 55)\n  (:id . 49))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 70)\n  (:start . 61) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 91)\n  (:start . 85) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 93) (:start . 92)\n  (:id . 55))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 107) (:start . 106)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 108) (:start . 107)\n  (:id . 60))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 127) (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 138) (:start . 135)\n  (:id . 65))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 152)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 164) (:start . 160)\n  (:id . 70))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 169) (:start . 165)\n  (:id . 71))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 172) (:start . 170)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 179) (:start . 176)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 186)\n  (:start . 180) (:id . 75))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 193)\n  (:start . 187) (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 77))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 198) (:start . 195)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 205)\n  (:start . 199) (:id . 79))\n ((:tag . "NN") (:stem . "6a") (:form . "6A") (:end . 208) (:start . 206)\n  (:id . 80))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 209) (:start . 208)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 210) (:start . 209)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s7.158) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102287@unknown@formal@none@1@S@While the number of macrophage-like cells in circulation is not significantly changed in the double mutant, the number of lamellocytes is decreased (see Figure 3), but the number of crystal cells is normal (see Figure 5A and 5C).@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "macrophage-like") (:form . "macrophage-like")\n  (:end . 35) (:start . 20) (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 41) (:start . 36)\n  (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "NN") (:stem . "circulation") (:form . "circulation") (:end . 56)\n  (:start . 45) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 77) (:start . 64) (:id . 52))\n ((:tag . "VBN") (:stem . "change") (:form . "changed") (:end . 85)\n  (:start . 78) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "double") (:form . "double") (:end . 99)\n  (:start . 93) (:id . 56))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 118)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "lamellocyte") (:form . "lamellocytes") (:end . 134)\n  (:start . 122) (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "decrease") (:form . "decreased") (:end . 147)\n  (:start . 138) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 152) (:start . 149)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 159)\n  (:start . 153) (:id . 67))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 163) (:start . 162)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 178)\n  (:start . 172) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 181) (:start . 179)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "crystal") (:form . "crystal") (:end . 189)\n  (:start . 182) (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 195)\n  (:start . 190) (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 198) (:start . 196)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 205)\n  (:start . 199) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 207) (:start . 206)\n  (:id . 79))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 210) (:start . 207)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 217)\n  (:start . 211) (:id . 81))\n ((:tag . "NN") (:stem . "5a") (:form . "5A") (:end . 220) (:start . 218)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 224) (:start . 221)\n  (:id . 83))\n ((:tag . "NN") (:stem . "5c") (:form . "5C") (:end . 227) (:start . 225)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s7.159) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102288@unknown@formal@none@1@S@These results demonstrate that adenosine signaling through the adenosine receptor is involved in the developmental arrest of adgf-a mutant, but that it does not play a role in fat body disintegration and macrophage differentiation.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 40)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 50)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 58)\n  (:start . 51) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 72)\n  (:start . 63) (:id . 50))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 81)\n  (:start . 73) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 93)\n  (:start . 85) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 114) (:start . 101) (:id . 56))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 121)\n  (:start . 115) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 58))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 138)\n  (:start . 132) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 61))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 143) (:start . 140)\n  (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 148) (:start . 144)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 156) (:start . 152)\n  (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 160) (:start . 157)\n  (:id . 66))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 165) (:start . 161)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 167) (:start . 166)\n  (:id . 68))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 172) (:start . 168)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 199) (:start . 185) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 74))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 214)\n  (:start . 204) (:id . 75))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 230) (:start . 215) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 77)))@@@1@36@((:ncues ((:id . :x7.160.1) (:span 157 160)))\n (:nscopes ((:id . :x7.160.1) (:span 157 230)))\n (:identifiers (:sid . :s7.160) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102290@unknown@formal@none@1@S@(A) Larvae of different genotypes were collected after L2/L3 molt, and the number of puparia was counted at different time points (x-axis: hours after egg laying).@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "NNP") (:stem . "Larvae") (:form . "Larvae") (:end . 10)\n  (:start . 4) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 23)\n  (:start . 14) (:id . 47))\n ((:tag . "NNS") (:stem . "genotype") (:form . "genotypes") (:end . 33)\n  (:start . 24) (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "collect") (:form . "collected") (:end . 48)\n  (:start . 39) (:id . 50))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 54) (:start . 49)\n  (:id . 51))\n ((:tag . "NN") (:stem . "l2/l3") (:form . "L2/L3") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "molt") (:form . "molt") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 81)\n  (:start . 75) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "puparia") (:form . "puparia") (:end . 92)\n  (:start . 85) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 96) (:start . 93)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "count") (:form . "counted") (:end . 104)\n  (:start . 97) (:id . 61))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 107) (:start . 105)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 117)\n  (:start . 108) (:id . 63))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 122) (:start . 118)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "point") (:form . "points") (:end . 129)\n  (:start . 123) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 131) (:start . 130)\n  (:id . 66))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 137)\n  (:start . 131) (:id . 67))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 138) (:start . 137)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 144)\n  (:start . 139) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 150)\n  (:start . 145) (:id . 70))\n ((:tag . "NN") (:stem . "egg") (:form . "egg") (:end . 154) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "laying") (:form . "laying") (:end . 161)\n  (:start . 155) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.162) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102291@unknown@formal@none@1@S@The y-axis shows the percentage of puparia out of all collected third-instar larvae (three vials each with 30 animals; the standard error is shown).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "y-axis") (:form . "y-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "NN") (:stem . "puparia") (:form . "puparia") (:end . 42)\n  (:start . 35) (:id . 48))\n ((:tag . "IN") (:stem . "out") (:form . "out") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "collect") (:form . "collected") (:end . 63)\n  (:start . 54) (:id . 52))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 76)\n  (:start . 64) (:id . 53))\n ((:tag . "FW") (:stem . "larvae") (:form . "larvae") (:end . 83)\n  (:start . 77) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "vial") (:form . "vials") (:end . 96) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 101) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 109) (:start . 107)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 117)\n  (:start . 110) (:id . 61))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 118) (:start . 117)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 122) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "NN") (:stem . "error") (:form . "error") (:end . 137)\n  (:start . 132) (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 146)\n  (:start . 141) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.163) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102292@unknown@formal@none@1@S@(B and C) Ring gland morphology in arrested adgf-a larvae.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 6) (:start . 3)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 8) (:start . 7)\n  (:id . 45))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 9) (:start . 8) (:id . 46))\n ((:tag . "NN") (:stem . "ring") (:form . "Ring") (:end . 14) (:start . 10)\n  (:id . 47))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 20) (:start . 15)\n  (:id . 48))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 31)\n  (:start . 21) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 34) (:start . 32)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "arrest") (:form . "arrested") (:end . 43)\n  (:start . 35) (:id . 51))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 50)\n  (:start . 44) (:id . 52))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 57)\n  (:start . 51) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 58) (:start . 57)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.164) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102293@unknown@formal@none@1@S@Approximately 8-d old mutant larva (i.e., 3 d after normal pupariation) with very extensive fat body disintegration (note the transparency of larva in the middle part with small white pieces of fat body) (B).@(((:tag . "RB") (:stem . "approximately") (:form . "Approximately")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "8-d") (:form . "8-d") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "old") (:form . "old") (:end . 21) (:start . 18)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "FW") (:stem . "larva") (:form . "larva") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 47))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 45) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 51) (:start . 46)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 58)\n  (:start . 52) (:id . 53))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 70)\n  (:start . 59) (:id . 54))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 56))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "extensive") (:form . "extensive") (:end . 91)\n  (:start . 82) (:id . 58))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 95) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 115) (:start . 101) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 62))\n ((:tag . "NN") (:stem . "note") (:form . "note") (:end . 121) (:start . 117)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NN") (:stem . "transparency") (:form . "transparency") (:end . 138)\n  (:start . 126) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 141) (:start . 139)\n  (:id . 66))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 147)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "middle") (:form . "middle") (:end . 161)\n  (:start . 155) (:id . 70))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 166) (:start . 162)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 171) (:start . 167)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 177)\n  (:start . 172) (:id . 73))\n ((:tag . "JJ") (:stem . "white") (:form . "white") (:end . 183)\n  (:start . 178) (:id . 74))\n ((:tag . "NNS") (:stem . "piece") (:form . "pieces") (:end . 190)\n  (:start . 184) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 76))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 197) (:start . 194)\n  (:id . 77))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 202) (:start . 198)\n  (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 205) (:start . 204)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 206) (:start . 205)\n  (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 83)))@@@1@42@((:identifiers (:sid . :s7.165) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102294@unknown@formal@none@1@S@The ring gland dissected from this larva (C) shows morphology of the normal ring gland before the degenerative changes of prothoracic gland starts (compare to schematic diagram to the left of [C], from [28]).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "dissect") (:form . "dissected") (:end . 24)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 43) (:start . 42)\n  (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 44) (:start . 43)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 61)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 64) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 75)\n  (:start . 69) (:id . 56))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 80) (:start . 76)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 86) (:start . 81)\n  (:id . 58))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 93)\n  (:start . 87) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "degenerative") (:form . "degenerative") (:end . 110)\n  (:start . 98) (:id . 61))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 118)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "prothoracic") (:form . "prothoracic") (:end . 133)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 139)\n  (:start . 134) (:id . 65))\n ((:tag . "NNS") (:stem . "start") (:form . "starts") (:end . 146)\n  (:start . 140) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 148) (:start . 147)\n  (:id . 67))\n ((:tag . "NN") (:stem . "compare") (:form . "compare") (:end . 155)\n  (:start . 148) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "schematic") (:form . "schematic") (:end . 168)\n  (:start . 159) (:id . 70))\n ((:tag . "NN") (:stem . "diagram") (:form . "diagram") (:end . 176)\n  (:start . 169) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "NN") (:stem . "left") (:form . "left") (:end . 188) (:start . 184)\n  (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 193) (:start . 192)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 194) (:start . 193)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 195) (:start . 194)\n  (:id . 78))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 79))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 201) (:start . 197)\n  (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 203) (:start . 202)\n  (:id . 81))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 205) (:start . 203)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 206) (:start . 205)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 207) (:start . 206)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s7.166) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102295@unknown@formal@none@1@S@(D–F) Expression of GFP-marked glue protein (Sgs?3-GFP) in salivary gland of the adgf-a mutant larvae and pupae.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "D–F") (:form . "D–F") (:end . 4) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 5) (:start . 4) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 16)\n  (:start . 6) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "gfp-marked") (:form . "GFP-marked") (:end . 30)\n  (:start . 20) (:id . 47))\n ((:tag . "NN") (:stem . "glue") (:form . "glue") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 43)\n  (:start . 36) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 45) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Sgs?3-GFP") (:form . "Sgs?3-GFP") (:end . 54)\n  (:start . 45) (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 87)\n  (:start . 81) (:id . 58))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 94)\n  (:start . 88) (:id . 59))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 111)\n  (:start . 106) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.167) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102296@unknown@formal@none@1@S@All late third-instar larvae express the glue protein as shown on dissected salivary gland (D).@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 21)\n  (:start . 9) (:id . 44))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 28)\n  (:start . 22) (:id . 45))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "glue") (:form . "glue") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 53)\n  (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 56) (:start . 54)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 62) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "dissect") (:form . "dissected") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 84)\n  (:start . 76) (:id . 54))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 90) (:start . 85)\n  (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 92) (:start . 91)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "D") (:form . "D") (:end . 93) (:start . 92)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.168) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102297@unknown@formal@none@1@S@Some mutants show typical expulsion from the glands with GFP totally external to the puparial case (E), while others do not expel glue proteins even after puparium formation (F).@(((:tag . "DT") (:stem . "some") (:form . "Some") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 25)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "expulsion") (:form . "expulsion") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 56) (:start . 52)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 60) (:start . 57)\n  (:id . 51))\n ((:tag . "RB") (:stem . "totally") (:form . "totally") (:end . 68)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "external") (:form . "external") (:end . 77)\n  (:start . 69) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "puparial") (:form . "puparial") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 98) (:start . 94)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "E") (:form . "E") (:end . 101) (:start . 100)\n  (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 61))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 109)\n  (:start . 104) (:id . 62))\n ((:tag . "NNS") (:stem . "other") (:form . "others") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "VBP") (:stem . "do") (:form . "do") (:end . 119) (:start . 117)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 123) (:start . 120)\n  (:id . 65))\n ((:tag . "VB") (:stem . "expel") (:form . "expel") (:end . 129)\n  (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "glue") (:form . "glue") (:end . 134) (:start . 130)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 143)\n  (:start . 135) (:id . 68))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 148) (:start . 144)\n  (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 154)\n  (:start . 149) (:id . 70))\n ((:tag . "NN") (:stem . "puparium") (:form . "puparium") (:end . 163)\n  (:start . 155) (:id . 71))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 173)\n  (:start . 164) (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 175) (:start . 174)\n  (:id . 73))\n ((:tag . "NN") (:stem . "f") (:form . "F") (:end . 176) (:start . 175)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 177) (:start . 176)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 178) (:start . 177)\n  (:id . 76)))@@@1@35@((:ncues ((:id . :x7.169.1) (:span 120 123)))\n (:nscopes ((:id . :x7.169.1) (:span 120 177)))\n (:identifiers (:sid . :s7.169) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102298@unknown@formal@none@1@S@Hormonal Regulation in the adgf-a Mutant@(((:tag . "JJ") (:stem . "hormonal") (:form . "Hormonal") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Regulation") (:form . "Regulation") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NNP") (:stem . "Mutant") (:form . "Mutant") (:end . 40)\n  (:start . 34) (:id . 47)))@@@1@6@((:identifiers (:sid . :s7.170) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102300@unknown@formal@none@1@S@The main source of developmental hormones in the Drosophila larva is the ring gland, composed of the prothoracic gland, corpus allatum, and corpus cardiacum [28].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 32) (:start . 19) (:id . 46))\n ((:tag . "NNS") (:stem . "hormone") (:form . "hormones") (:end . 41)\n  (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "compose") (:form . "composed") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "prothoracic") (:form . "prothoracic") (:end . 112)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 118)\n  (:start . 113) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 62))\n ((:tag . "NN") (:stem . "corpus") (:form . "corpus") (:end . 126)\n  (:start . 120) (:id . 63))\n ((:tag . "NN") (:stem . "allatum") (:form . "allatum") (:end . 134)\n  (:start . 127) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "NN") (:stem . "corpus") (:form . "corpus") (:end . 146)\n  (:start . 140) (:id . 67))\n ((:tag . "NN") (:stem . "cardiacum") (:form . "cardiacum") (:end . 156)\n  (:start . 147) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 158) (:start . 157)\n  (:id . 69))\n ((:tag . "CD") (:stem . "28") (:form . "28") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 161) (:start . 160)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.172) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102301@unknown@formal@none@1@S@The prothoracic gland releases the steroid molting hormone ecdysone, which is converted to an active form, 20-hydroxyecdysone (20E), by the fat body as well as some of the target organs [29].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "prothoracic") (:form . "prothoracic") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "release") (:form . "releases") (:end . 30)\n  (:start . 22) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 42)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "molting") (:form . "molting") (:end . 50)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 74) (:start . 69)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 77) (:start . 75)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "convert") (:form . "converted") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 100)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 105) (:start . 101)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "NN") (:stem . "20-hydroxyecdysone") (:form . "20-hydroxyecdysone")\n  (:end . 125) (:start . 107) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "20e") (:form . "20E") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 131) (:start . 130)\n  (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 132) (:start . 131)\n  (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 143) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 148) (:start . 144)\n  (:id . 68))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 151) (:start . 149)\n  (:id . 69))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 159) (:start . 157)\n  (:id . 71))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 171) (:start . 168)\n  (:id . 74))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 178)\n  (:start . 172) (:id . 75))\n ((:tag . "NNS") (:stem . "organ") (:form . "organs") (:end . 185)\n  (:start . 179) (:id . 76))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 187) (:start . 186)\n  (:id . 77))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 189) (:start . 187)\n  (:id . 78))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 190) (:start . 189)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s7.173) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102302@unknown@formal@none@1@S@The block of pupariation in the adgf-a mutant suggested that the level of ecdysone in these larvae might not be sufficient to initiate pupariation.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 38)\n  (:start . 32) (:id . 48))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBD") (:stem . "suggest") (:form . "suggested") (:end . 55)\n  (:start . 46) (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 91) (:start . 86)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 111) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 122)\n  (:start . 112) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 63))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 134)\n  (:start . 126) (:id . 64))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 146)\n  (:start . 135) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x7.174.2) (:span 99 104)) ((:id . :x7.174.3) (:span 46 55)))\n (:ncues ((:id . :x7.174.1) (:span 105 108)))\n (:hscopes ((:id . :x7.174.2) (:span 99 146))\n  ((:id . :x7.174.3) (:span 46 146)))\n (:nscopes ((:id . :x7.174.1) (:span 105 146)))\n (:identifiers (:sid . :s7.174) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102303@unknown@formal@none@1@S@To test this possibility, we tried to rescue the phenotype by feeding mutant larvae 20E, which can initiate pupariation in the ecd1 mutant, which has an extremely low level of ecdysone [30,31].@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 25) (:start . 24)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "try") (:form . "tried") (:end . 34) (:start . 29)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 44)\n  (:start . 38) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 51))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 58)\n  (:start . 49) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "feed") (:form . "feeding") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . "JJ") (:stem . "larvae") (:form . "larvae") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "NN") (:stem . "20e") (:form . "20E") (:end . 87) (:start . 84)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 98) (:start . 95)\n  (:id . 60))\n ((:tag . "VB") (:stem . "initiate") (:form . "initiate") (:end . 107)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 119)\n  (:start . 108) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "ecd1") (:form . "ecd1") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 138)\n  (:start . 132) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 139) (:start . 138)\n  (:id . 67))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 145)\n  (:start . 140) (:id . 68))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 149) (:start . 146)\n  (:id . 69))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 152) (:start . 150)\n  (:id . 70))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 162)\n  (:start . 153) (:id . 71))\n ((:tag . "JJ") (:stem . "low") (:form . "low") (:end . 166) (:start . 163)\n  (:id . 72))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 172)\n  (:start . 167) (:id . 73))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 175) (:start . 173)\n  (:id . 74))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 184)\n  (:start . 176) (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 186) (:start . 185)\n  (:id . 76))\n ((:tag . "CD") (:stem . "30,31") (:form . "30,31") (:end . 191)\n  (:start . 186) (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 192) (:start . 191)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s7.175) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102304@unknown@formal@none@1@S@The results (Figure 7A) clearly demonstrate that the adgf-a mutant larvae are responsive to ecdysone and that this treatment restores the pupariation frequency to almost wild-type level.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 22) (:start . 20)\n  (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 23) (:start . 22)\n  (:id . 47))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 31)\n  (:start . 24) (:id . 48))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 43)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 52) (:start . 49)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 59)\n  (:start . 53) (:id . 52))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 73)\n  (:start . 67) (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 88)\n  (:start . 78) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 100)\n  (:start . 92) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 109) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 114) (:start . 110)\n  (:id . 61))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "VBZ") (:stem . "restore") (:form . "restores") (:end . 133)\n  (:start . 125) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 64))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 149)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 159)\n  (:start . 150) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 162) (:start . 160)\n  (:id . 67))\n ((:tag . "RB") (:stem . "almost") (:form . "almost") (:end . 169)\n  (:start . 163) (:id . 68))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 179)\n  (:start . 170) (:id . 69))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 185)\n  (:start . 180) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s7.176) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102305@unknown@formal@none@1@S@The delay in development is also significantly reduced (Figure 7A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "delay") (:form . "delay") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 24)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 46) (:start . 33) (:id . 48))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 50))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 62)\n  (:start . 56) (:id . 51))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 66) (:start . 65)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 67) (:start . 66)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.177) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102306@unknown@formal@none@1@S@Since the adgf-a mutant shows certain precocious metamorphic changes (macrophage differentiation and fat body disintegration), we speculated that a reduced ecdysteroid level could be caused by precocious degeneration of the prothoracic part of the ring gland.@(((:tag . "IN") (:stem . "since") (:form . "Since") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "JJ") (:stem . "metamorphic") (:form . "metamorphic") (:end . 60)\n  (:start . 49) (:id . 49))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 68)\n  (:start . 61) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 70) (:start . 69)\n  (:id . 51))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 80)\n  (:start . 70) (:id . 52))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 96) (:start . 81) (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 54))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 104) (:start . 101)\n  (:id . 55))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 109) (:start . 105)\n  (:id . 56))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 124) (:start . 110) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 125) (:start . 124)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 126) (:start . 125)\n  (:id . 59))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 129) (:start . 127)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "speculate") (:form . "speculated") (:end . 140)\n  (:start . 130) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 147) (:start . 146)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 155)\n  (:start . 148) (:id . 64))\n ((:tag . "NN") (:stem . "ecdysteroid") (:form . "ecdysteroid") (:end . 167)\n  (:start . 156) (:id . 65))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 173)\n  (:start . 168) (:id . 66))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 179)\n  (:start . 174) (:id . 67))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 182) (:start . 180)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 189)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 192) (:start . 190)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 203)\n  (:start . 193) (:id . 71))\n ((:tag . "NN") (:stem . "degeneration") (:form . "degeneration") (:end . 216)\n  (:start . 204) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 219) (:start . 217)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 223) (:start . 220)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "prothoracic") (:form . "prothoracic") (:end . 235)\n  (:start . 224) (:id . 75))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 240) (:start . 236)\n  (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 243) (:start . 241)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 247) (:start . 244)\n  (:id . 78))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 252) (:start . 248)\n  (:id . 79))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 258)\n  (:start . 253) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x7.178.1) (:span 174 179))\n  ((:id . :x7.178.2) (:span 130 140)))\n (:hscopes ((:id . :x7.178.1) (:span 146 258))\n  ((:id . :x7.178.2) (:span 130 258)))\n (:identifiers (:sid . :s7.178) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102307@unknown@formal@none@1@S@However, the overall structure of the ring gland is not visibly affected even in the oldest larvae (10 d, i.e., 5 d after the heterozygous siblings pupariated) with a fully disintegrated fat body (Figure 7B and 7C).@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "overall") (:form . "overall") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 48) (:start . 43)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "visibly") (:form . "visibly") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "VBN") (:stem . "affect") (:form . "affected") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "JJS") (:stem . "old") (:form . "oldest") (:end . 91) (:start . 85)\n  (:id . 58))\n ((:tag . "NN") (:stem . "larvae") (:form . "larvae") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 104) (:start . 103)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 63))\n ((:tag . "FW") (:stem . "i.e.") (:form . "i.e.") (:end . 110) (:start . 106)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 65))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 113) (:start . 112)\n  (:id . 66))\n ((:tag . "NN") (:stem . "d") (:form . "d") (:end . 115) (:start . 114)\n  (:id . 67))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 121)\n  (:start . 116) (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 138)\n  (:start . 126) (:id . 70))\n ((:tag . "NNS") (:stem . "sibling") (:form . "siblings") (:end . 147)\n  (:start . 139) (:id . 71))\n ((:tag . "VBN") (:stem . "pupariate") (:form . "pupariated") (:end . 158)\n  (:start . 148) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 159) (:start . 158)\n  (:id . 73))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 164) (:start . 160)\n  (:id . 74))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 166) (:start . 165)\n  (:id . 75))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 172)\n  (:start . 167) (:id . 76))\n ((:tag . "VBN") (:stem . "disintegrate") (:form . "disintegrated")\n  (:end . 186) (:start . 173) (:id . 77))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 190) (:start . 187)\n  (:id . 78))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 195) (:start . 191)\n  (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 80))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 203)\n  (:start . 197) (:id . 81))\n ((:tag . "NN") (:stem . "7b") (:form . "7B") (:end . 206) (:start . 204)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 210) (:start . 207)\n  (:id . 83))\n ((:tag . "NN") (:stem . "7c") (:form . "7C") (:end . 213) (:start . 211)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 214) (:start . 213)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 215) (:start . 214)\n  (:id . 86)))@@@1@45@((:ncues ((:id . :x7.179.1) (:span 52 55)))\n (:nscopes ((:id . :x7.179.1) (:span 9 195)))\n (:identifiers (:sid . :s7.179) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102308@unknown@formal@none@1@S@We also used a transgenic line carrying the Sgs?3-GFP construct, which was previously used to monitor the effects of ecdysteroid levels on glue protein expression in salivary glands [32].@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 25)\n  (:start . 15) (:id . 46))\n ((:tag . "NN") (:stem . "line") (:form . "line") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Sgs?3-GFP") (:form . "Sgs?3-GFP") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 70) (:start . 65)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 90) (:start . 86)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "VB") (:stem . "monitor") (:form . "monitor") (:end . 101)\n  (:start . 94) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 113)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ecdysteroid") (:form . "ecdysteroid") (:end . 128)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 135)\n  (:start . 129) (:id . 63))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 138) (:start . 136)\n  (:id . 64))\n ((:tag . "NN") (:stem . "glue") (:form . "glue") (:end . 143) (:start . 139)\n  (:id . 65))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 151)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 162)\n  (:start . 152) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 165) (:start . 163)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 174)\n  (:start . 166) (:id . 69))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 181)\n  (:start . 175) (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "CD") (:stem . "32") (:form . "32") (:end . 185) (:start . 183)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 187) (:start . 186)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.180) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102310@unknown@formal@none@1@S@Mutants that pupariated usually showed typical GFP expectoration, indicating the presence of a high premetamorphic peak of ecdysteroids (Figure 7E).@(((:tag . "NNS") (:stem . "mutant") (:form . "Mutants") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "pupariate") (:form . "pupariated") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 38) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "typical") (:form . "typical") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expectoration") (:form . "expectoration")\n  (:end . 64) (:start . 51) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 76)\n  (:start . 66) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 52))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 89)\n  (:start . 81) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 92) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 94) (:start . 93)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "premetamorphic") (:form . "premetamorphic")\n  (:end . 114) (:start . 100) (:id . 57))\n ((:tag . "NN") (:stem . "peak") (:form . "peak") (:end . 119) (:start . 115)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "ecdysteroid") (:form . "ecdysteroids") (:end . 135)\n  (:start . 123) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 137) (:start . 136)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 143)\n  (:start . 137) (:id . 62))\n ((:tag . "NN") (:stem . "7e") (:form . "7E") (:end . 146) (:start . 144)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x7.182.1) (:span 66 76)))\n (:hscopes ((:id . :x7.182.1) (:span 66 135)))\n (:identifiers (:sid . :s7.182) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102311@unknown@formal@none@1@S@In some cases, GFP was secreted into the lumen of salivary glands, but was not expectorated (Figure 7F), which is similar to the defect seen in animals expressing the dominant-negative form of ecdysone receptor driven by the Sgs3-Gal4 driver [33].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 22) (:start . 19)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "secrete") (:form . "secreted") (:end . 31)\n  (:start . 23) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . 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5102312@unknown@formal@none@1@S@These results demonstrate that the target tissues of adgf-a mutants are normally responsive to ecdysteroids and that they are probably capable of releasing ecdysteroids, although the level of ecdysteroids might vary.?>@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "target") (:form . "target") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 67)\n  (:start . 60) (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 52))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 80)\n  (:start . 72) (:id . 53))\n ((:tag . "JJ") (:stem . "responsive") (:form . "responsive") (:end . 91)\n  (:start . 81) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "ecdysteroid") (:form . "ecdysteroids") (:end . 107)\n  (:start . 95) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 121) (:start . 117)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 125) (:start . 122)\n  (:id . 60))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 134)\n  (:start . 126) (:id . 61))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 142)\n  (:start . 135) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "release") (:form . "releasing") (:end . 155)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "ecdysteroid") (:form . "ecdysteroids") (:end . 168)\n  (:start . 156) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 178)\n  (:start . 170) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 188)\n  (:start . 183) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "ecdysteroid") (:form . "ecdysteroids") (:end . 204)\n  (:start . 192) (:id . 71))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 210)\n  (:start . 205) (:id . 72))\n ((:tag . "VB") (:stem . "vary.?>") (:form . "vary.?>") (:end . 218)\n  (:start . 211) (:id . 73)))@@@1@32@((:hcues ((:id . :x7.184.1) (:span 205 210))\n  ((:id . :x7.184.2) (:span 126 134)))\n (:hscopes ((:id . :x7.184.1) (:span 205 215))\n  ((:id . :x7.184.2) (:span 126 168)))\n (:identifiers (:sid . :s7.184) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102313@unknown@formal@none@1@S@ADGF-A Genetically Interacts with Toll Signaling Pathway@(((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "genetically") (:form . "Genetically") (:end . 18)\n  (:start . 7) (:id . 43))\n ((:tag . "VBZ") (:stem . "interact") (:form . "Interacts") (:end . 28)\n  (:start . 19) (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 38) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Signaling") (:form . "Signaling") (:end . 48)\n  (:start . 39) (:id . 47))\n ((:tag . "NNP") (:stem . "Pathway") (:form . "Pathway") (:end . 56)\n  (:start . 49) (:id . 48)))@@@1@7@((:identifiers (:sid . :s7.185) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102314@unknown@formal@none@1@S@The antimicrobial response of Drosophila includes at least two distinct signaling pathways [34]—the Toll signaling pathway, which leads to the activation of two nuclear factor kappa B (NF-?B) factors, Dorsal-related immunity factor (DIF) and dorsal (DL); and the immune deficiency protein pathway activating the third NF-?B factor, Relish (REL).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "antimicrobial") (:form . "antimicrobial")\n  (:end . 17) (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 26)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 45))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 40)\n  (:start . 30) (:id . 46))\n ((:tag . "VBZ") (:stem . "include") (:form . "includes") (:end . 49)\n  (:start . 41) (:id . 47))\n ((:tag . "IN") (:stem . 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5102315@unknown@formal@none@1@S@A zygotic null mutation in cactus (cact; a Drosophila inhibitor of NF-?B) leads to hyperproliferation of hemocytes, melanotic tumor formation, disintegration of fat body, and slower larval development, with 60% larval lethality, as well as a thin body-shape phenotype [35].@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "zygotic") (:form . "zygotic") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 23)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cactus") (:form . "cactus") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cact") (:form . 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"[") (:end . 269) (:start . 268)\n  (:id . 90))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 271) (:start . 269)\n  (:id . 91))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 272) (:start . 271)\n  (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 273) (:start . 272)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s7.187) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102316@unknown@formal@none@1@S@All of these phenotypes are strikingly similar to the abnormalities seen in adgf-a mutants, which was our first clue as to a possible interaction of ADGF-A with the Toll signaling pathway.@(((:tag . "DT") (:stem . "all") (:form . "All") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "RB") (:stem . "strikingly") (:form . "strikingly") (:end . 38)\n  (:start . 28) (:id . 47))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 46)\n  (:start . 39) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "abnormality") (:form . "abnormalities") (:end . 67)\n  (:start . 54) (:id . 51))\n ((:tag . "VBN") (:stem . "see") (:form . "seen") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 90)\n  (:start . 83) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 56))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 97) (:start . 92)\n  (:id . 57))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 101) (:start . 98)\n  (:id . 58))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 105) (:start . 102)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 111)\n  (:start . 106) (:id . 60))\n ((:tag . "NN") (:stem . "clue") (:form . "clue") (:end . 116) (:start . 112)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 133)\n  (:start . 125) (:id . 65))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 145)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 155)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 160) (:start . 156)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 169) (:start . 165)\n  (:id . 71))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 179)\n  (:start . 170) (:id . 72))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 187)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 188) (:start . 187)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x7.188.1) (:span 125 133)))\n (:hscopes ((:id . :x7.188.1) (:span 125 187)))\n (:identifiers (:sid . :s7.188) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102317@unknown@formal@none@1@S@We hypothesized that the activity of ADGF-A is suppressed by Toll signaling, resulting in similar phenotypes of the adgf-a mutation and constitutive activation of Toll pathway.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "hypothesize") (:form . "hypothesized") (:end . 15)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 65) (:start . 61)\n  (:id . 52))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 75)\n  (:start . 66) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 86)\n  (:start . 77) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 97)\n  (:start . 90) (:id . 57))\n ((:tag . "NNS") (:stem . "phenotype") (:form . "phenotypes") (:end . 108)\n  (:start . 98) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 122)\n  (:start . 116) (:id . 61))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 131)\n  (:start . 123) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "constitutive") (:form . "constitutive") (:end . 148)\n  (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 159)\n  (:start . 149) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 162) (:start . 160)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 167) (:start . 163)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 175)\n  (:start . 168) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 176) (:start . 175)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x7.189.1) (:span 3 15)))\n (:hscopes ((:id . :x7.189.1) (:span 3 175)))\n (:identifiers (:sid . :s7.189) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102318@unknown@formal@none@1@S@To test this hypothesis, we crossed transgenic flies carrying ADGF-A gene under the control of a heat-shock promoter on Chromosome II (HS-ADGF-A) with cactE8 (a lethal allele of cact on Chromosome II, which, in combination with cactD13, results in a zygotic null combination, or, with cactIIIG, results in zygotic hypomorphic combination).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "test") (:form . "test") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 23)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "cross") (:form . "crossed") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 61)\n  (:start . 53) (:id . 51))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 68)\n  (:start . 62) (:id . 52))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 73) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 79) (:start . 74)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 91)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "heat-shock") (:form . "heat-shock") (:end . 107)\n  (:start . 97) (:id . 59))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 130)\n  (:start . 120) (:id . 62))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 135) (:start . 134)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 144)\n  (:start . 135) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 145) (:start . 144)\n  (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cacte8") (:form . 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"WDT") (:stem . "which") (:form . "which") (:end . 206)\n  (:start . 201) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 207) (:start . 206)\n  (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 210) (:start . 208)\n  (:id . 81))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 222)\n  (:start . 211) (:id . 82))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 227) (:start . 223)\n  (:id . 83))\n ((:tag . "NN") (:stem . "cactd13") (:form . "cactD13") (:end . 235)\n  (:start . 228) (:id . 84))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 236) (:start . 235)\n  (:id . 85))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 244)\n  (:start . 237) (:id . 86))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 87))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 249) (:start . 248)\n  (:id . 88))\n ((:tag . "JJ") (:stem . "zygotic") (:form . "zygotic") (:end . 257)\n  (:start . 250) (:id . 89))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 262) (:start . 258)\n  (:id . 90))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 274)\n  (:start . 263) (:id . 91))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 275) (:start . 274)\n  (:id . 92))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 278) (:start . 276)\n  (:id . 93))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 279) (:start . 278)\n  (:id . 94))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 284) (:start . 280)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "cactIIIG") (:form . "cactIIIG") (:end . 293)\n  (:start . 285) (:id . 96))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 294) (:start . 293)\n  (:id . 97))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 302)\n  (:start . 295) (:id . 98))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 305) (:start . 303)\n  (:id . 99))\n ((:tag . "JJ") (:stem . "zygotic") (:form . "zygotic") (:end . 313)\n  (:start . 306) (:id . 100))\n ((:tag . "JJ") (:stem . "hypomorphic") (:form . "hypomorphic") (:end . 325)\n  (:start . 314) (:id . 101))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 337)\n  (:start . 326) (:id . 102))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 338) (:start . 337)\n  (:id . 103))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 339) (:start . 338)\n  (:id . 104)))@@@1@63@((:identifiers (:sid . :s7.190) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102320@unknown@formal@none@1@S@The rescue could be increased by multiple heat shocks before pupariation to 7-fold (unpublished data).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "shock") (:form . "shocks") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 60)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 72)\n  (:start . 61) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "7-fold") (:form . "7-fold") (:end . 82)\n  (:start . 76) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.192) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102321@unknown@formal@none@1@S@The suppression of melanotic tumor formation is also significant (from more than 80% down to 26%, Figure 8B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "suppression") (:form . "suppression") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 28)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 44)\n  (:start . 35) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 64)\n  (:start . 53) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 66) (:start . 65)\n  (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 70) (:start . 66)\n  (:id . 52))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "CD") (:stem . "80") (:form . "80") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "down") (:form . "down") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 95) (:start . 93)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 96) (:start . 95)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 104)\n  (:start . 98) (:id . 62))\n ((:tag . "NN") (:stem . "8b") (:form . "8B") (:end . 107) (:start . 105)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 108) (:start . 107)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.193) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102322@unknown@formal@none@1@S@The most severe cact null mutation (cactE8/cactD13), leading to developmental arrest in larvae (less than 8% pupate), is partially rescued in animals with overexpression of ADGF-A when the pupariation rate is increased 3-fold (Figure 8A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "severe") (:form . "severe") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cact") (:form . "cact") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "null") (:form . "null") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 36) (:start . 35)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cacte8/cactd13") (:form . "cactE8/cactD13")\n  (:end . 50) (:start . 36) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 51) (:start . 50)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 77) (:start . 64) (:id . 54))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 96) (:start . 95)\n  (:id . 58))\n ((:tag . "JJR") (:stem . "less") (:form . "less") (:end . 100) (:start . 96)\n  (:id . 59))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 105) (:start . 101)\n  (:id . 60))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 107) (:start . 106)\n  (:id . 61))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "NN") (:stem . "pupate") (:form . "pupate") (:end . 115)\n  (:start . 109) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 116) (:start . 115)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 120) (:start . 118)\n  (:id . 66))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 130)\n  (:start . 121) (:id . 67))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 138)\n  (:start . 131) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 141) (:start . 139)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "animal") (:form . "animals") (:end . 149)\n  (:start . 142) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 154) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 169) (:start . 155) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 172) (:start . 170)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 179)\n  (:start . 173) (:id . 74))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 184) (:start . 180)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 76))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 200)\n  (:start . 189) (:id . 77))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 205) (:start . 201)\n  (:id . 78))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 208) (:start . 206)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 218)\n  (:start . 209) (:id . 80))\n ((:tag . "RB") (:stem . "3-fold") (:form . "3-fold") (:end . 225)\n  (:start . 219) (:id . 81))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 227) (:start . 226)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 233)\n  (:start . 227) (:id . 83))\n ((:tag . "NN") (:stem . "8a") (:form . "8A") (:end . 236) (:start . 234)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 237) (:start . 236)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s7.194) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102323@unknown@formal@none@1@S@These results demonstrate that ADGF-A overexpression can partially rescue the effects of constitutively active Toll signaling in larvae, mainly the developmental arrest, but also the melanotic tumor formation, in the case of hypomorphic cact mutants.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "demonstrate") (:form . "demonstrate") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 30) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 37)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 52) (:start . 38) (:id . 47))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 56) (:start . 53)\n  (:id . 48))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 73)\n  (:start . 67) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "RB") (:stem . "constitutively") (:form . "constitutively")\n  (:end . 103) (:start . 89) (:id . 54))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 110)\n  (:start . 104) (:id . 55))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 115) (:start . 111)\n  (:id . 56))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 125)\n  (:start . 116) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 135)\n  (:start . 129) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 143)\n  (:start . 137) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 147) (:start . 144)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 161) (:start . 148) (:id . 63))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 168)\n  (:start . 162) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 169) (:start . 168)\n  (:id . 65))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 173) (:start . 170)\n  (:id . 66))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 178) (:start . 174)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 192)\n  (:start . 183) (:id . 69))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 198)\n  (:start . 193) (:id . 70))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 208)\n  (:start . 199) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 209) (:start . 208)\n  (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 74))\n ((:tag . "NN") (:stem . "case") (:form . "case") (:end . 221) (:start . 217)\n  (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 224) (:start . 222)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "hypomorphic") (:form . "hypomorphic") (:end . 236)\n  (:start . 225) (:id . 77))\n ((:tag . "NN") (:stem . "cact") (:form . "cact") (:end . 241) (:start . 237)\n  (:id . 78))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 249)\n  (:start . 242) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 80)))@@@1@39@((:identifiers (:sid . :s7.195) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102324@unknown@formal@none@1@S@Genetic Interactions of Toll Signaling and ADGF-A@(((:tag . "JJ") (:stem . "genetic") (:form . "Genetic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNPS") (:stem . "Interaction") (:form . "Interactions") (:end . 20)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Signaling") (:form . "Signaling") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 49)\n  (:start . 43) (:id . 48)))@@@1@7@((:identifiers (:sid . :s7.196) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102325@unknown@formal@none@1@S@Survival rate and melanotic tumor formation were compared in mutants in the Toll signaling pathway and in similar mutants with overexpression of ADGF-A using the HS-ADGF-A construct.@(((:tag . "NN") (:stem . "survival") (:form . "Survival") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 43)\n  (:start . 34) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 48) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 68)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 80) (:start . 76)\n  (:id . 54))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 90)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 98)\n  (:start . 91) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 113)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "overexpression") (:form . "overexpression")\n  (:end . 141) (:start . 127) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 144) (:start . 142)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 151)\n  (:start . 145) (:id . 64))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 157) (:start . 152)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 171)\n  (:start . 162) (:id . 67))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 181)\n  (:start . 172) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.197) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102326@unknown@formal@none@1@S@(A) The bar graph shows the percentage of the pupae (blue bars) and adult flies (purple bars) demonstrating the larval and pupal survival of each genotype.@(((:tag . "(") (:stem . "(") (:form . "(") (:end . 1) (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "a") (:form . "A") (:end . 2) (:start . 1)\n  (:id . 43))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 3) (:start . 2) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "The") (:end . 7) (:start . 4)\n  (:id . 45))\n ((:tag . "NN") (:stem . "bar") (:form . "bar") (:end . 11) (:start . 8)\n  (:id . 46))\n ((:tag . "NN") (:stem . "graph") (:form . "graph") (:end . 17) (:start . 12)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 23) (:start . 18)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 49))\n ((:tag . "NN") (:stem . "percentage") (:form . "percentage") (:end . 38)\n  (:start . 28) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "pupae") (:form . "pupae") (:end . 51) (:start . 46)\n  (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 53) (:start . 52)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "blue") (:form . "blue") (:end . 57) (:start . 53)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 62) (:start . 58)\n  (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 63) (:start . 62)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "adult") (:form . "adult") (:end . 73) (:start . 68)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 79) (:start . 74)\n  (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "purple") (:form . "purple") (:end . 87)\n  (:start . 81) (:id . 62))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 92) (:start . 88)\n  (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "demonstrate") (:form . "demonstrating")\n  (:end . 107) (:start . 94) (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 118)\n  (:start . 112) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 128)\n  (:start . 123) (:id . 69))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 137)\n  (:start . 129) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 71))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 145) (:start . 141)\n  (:id . 72))\n ((:tag . "NN") (:stem . "genotype") (:form . "genotype") (:end . 154)\n  (:start . 146) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 155) (:start . 154)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.198) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102327@unknown@formal@none@1@S@The x-axis shows the genotypes and is shared with (B).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "x-axis") (:form . "x-axis") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "genotype") (:form . "genotypes") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 54) (:start . 53)\n  (:id . 54)))@@@1@13@((:identifiers (:sid . :s7.199) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102328@unknown@formal@none@1@S@Flies heterozygous for the cact mutation were used as a control.@(((:tag . "NNS") (:stem . "fly") (:form . "Flies") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "heterozygous") (:form . "heterozygous") (:end . 18)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cact") (:form . "cact") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 40)\n  (:start . 32) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 45) (:start . 41)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 50) (:start . 46)\n  (:id . 49))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 55) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 64) (:start . 63)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.200) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102330@unknown@formal@none@1@S@Discussion@(((:tag . "NN") (:stem . "discussion") (:form . "Discussion") (:end . 10)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s7.202) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102331@unknown@formal@none@1@S@ADA Deficiency in Drosophila Causes Abnormal Hemocyte Development, Melanotic Tumor Formation, Fat Body Degeneration, and Delayed Development@(((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Deficiency") (:form . "Deficiency") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NNP") (:stem . "Causes") (:form . "Causes") (:end . 35)\n  (:start . 29) (:id . 46))\n ((:tag . "NNP") (:stem . "Abnormal") (:form . "Abnormal") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocyte") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 65)\n  (:start . 54) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Melanotic") (:form . "Melanotic") (:end . 76)\n  (:start . 67) (:id . 51))\n ((:tag . "NNP") (:stem . "Tumor") (:form . "Tumor") (:end . 82) (:start . 77)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Formation") (:form . "Formation") (:end . 92)\n  (:start . 83) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Fat") (:form . "Fat") (:end . 97) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Body") (:form . "Body") (:end . 102) (:start . 98)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Degeneration") (:form . "Degeneration")\n  (:end . 115) (:start . 103) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Delayed") (:form . "Delayed") (:end . 128)\n  (:start . 121) (:id . 60))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 140)\n  (:start . 129) (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.203) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102332@unknown@formal@none@1@S@We have established an ADA deficiency model in Drosophila in order to study the effects of altered adenosine levels in vivo.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 19)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "deficiency") (:form . "deficiency") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 57)\n  (:start . 47) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "alter") (:form . "altered") (:end . 98)\n  (:start . 91) (:id . 58))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 108)\n  (:start . 99) (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.204) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102333@unknown@formal@none@1@S@We produced a loss-of-function mutation in the ADGF-A gene, which produces a product (ADGF-A) with ADA activity.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "loss-of-function") (:form . "loss-of-function")\n  (:end . 30) (:start . 14) (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 53)\n  (:start . 47) (:id . 49))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 58) (:start . 54)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "produce") (:form . "produces") (:end . 74)\n  (:start . 66) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 84)\n  (:start . 77) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 92)\n  (:start . 86) (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 111)\n  (:start . 103) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s7.205) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102334@unknown@formal@none@1@S@When homozygous, the mutation causes abnormal hemocyte development, leading to melanotic tumor formation [36], as well as fat-body disintegration associated with death during the larval stage or delayed transition to the pupal stage of development.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 36)\n  (:start . 30) (:id . 47))\n ((:tag . "JJ") (:stem . "abnormal") (:form . "abnormal") (:end . 45)\n  (:start . 37) (:id . 48))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 54)\n  (:start . 46) (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 75)\n  (:start . 68) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "melanotic") (:form . "melanotic") (:end . 88)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "tumor") (:form . "tumor") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 104)\n  (:start . 95) (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 113) (:start . 111)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 118) (:start . 114)\n  (:id . 62))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 63))\n ((:tag . "NN") (:stem . "fat-body") (:form . "fat-body") (:end . 130)\n  (:start . 122) (:id . 64))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 145) (:start . 131) (:id . 65))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 167)\n  (:start . 162) (:id . 68))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 174)\n  (:start . 168) (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 185)\n  (:start . 179) (:id . 71))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 191)\n  (:start . 186) (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 194) (:start . 192)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 202)\n  (:start . 195) (:id . 74))\n ((:tag . "NN") (:stem . "transition") (:form . "transition") (:end . 213)\n  (:start . 203) (:id . 75))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 216) (:start . 214)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 226)\n  (:start . 221) (:id . 78))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 232)\n  (:start . 227) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 80))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 247)\n  (:start . 236) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 248) (:start . 247)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s7.206) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102335@unknown@formal@none@1@S@In agreement with our previous study using cells cultured in vitro [16], here we have shown that ADA enzymatic activity is essential for ADGF-A function in vivo, when this function is assayed by testing for rescue of the mutant phenotype.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 42) (:start . 37)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 48) (:start . 43)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 77) (:start . 73)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 80) (:start . 78)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 85) (:start . 81)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 91) (:start . 86)\n  (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 96) (:start . 92)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 100) (:start . 97)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 110)\n  (:start . 101) (:id . 63))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 122) (:start . 120)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 132)\n  (:start . 123) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 143)\n  (:start . 137) (:id . 68))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 152)\n  (:start . 144) (:id . 69))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 160) (:start . 156)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 166) (:start . 162)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 171) (:start . 167)\n  (:id . 74))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 180)\n  (:start . 172) (:id . 75))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 183) (:start . 181)\n  (:id . 76))\n ((:tag . "VBN") (:stem . "assay") (:form . "assayed") (:end . 191)\n  (:start . 184) (:id . 77))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 194) (:start . 192)\n  (:id . 78))\n ((:tag . "VBG") (:stem . "test") (:form . "testing") (:end . 202)\n  (:start . 195) (:id . 79))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 206) (:start . 203)\n  (:id . 80))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 213)\n  (:start . 207) (:id . 81))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 216) (:start . 214)\n  (:id . 82))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 220) (:start . 217)\n  (:id . 83))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 227)\n  (:start . 221) (:id . 84))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 237)\n  (:start . 228) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 238) (:start . 237)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s7.207) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102336@unknown@formal@none@1@S@Just as increased levels of both ADA substrates, adenosine and deoxyadenosine, are found in blood of SCID patients [5], adgf-a mutant larvae also have elevated levels of adenosine and deoxyadenosine, indicating that the mutant phenotype is caused by disturbance in the turnover of these nucleosides.@(((:tag . "RB") (:stem . "just") (:form . "Just") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "increase") (:form . "increased") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "ADA") (:form . "ADA") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "substrate") (:form . "substrates") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 48) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 58)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 77) (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 54))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 91) (:start . 89)\n  (:id . 57))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 97) (:start . 92)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . 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"VBP") (:stem . "have") (:form . "have") (:end . 150) (:start . 146)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 159)\n  (:start . 151) (:id . 71))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 166)\n  (:start . 160) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 73))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 179)\n  (:start . 170) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 183) (:start . 180)\n  (:id . 75))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 198) (:start . 184) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 210)\n  (:start . 200) (:id . 78))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 215) (:start . 211)\n  (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 219) (:start . 216)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 226)\n  (:start . 220) (:id . 81))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 236)\n  (:start . 227) (:id . 82))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 239) (:start . 237)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 246)\n  (:start . 240) (:id . 84))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 249) (:start . 247)\n  (:id . 85))\n ((:tag . "NN") (:stem . "disturbance") (:form . "disturbance") (:end . 261)\n  (:start . 250) (:id . 86))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 268) (:start . 265)\n  (:id . 88))\n ((:tag . "NN") (:stem . "turnover") (:form . "turnover") (:end . 277)\n  (:start . 269) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 280) (:start . 278)\n  (:id . 90))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 286)\n  (:start . 281) (:id . 91))\n ((:tag . "NNS") (:stem . "nucleoside") (:form . "nucleosides") (:end . 298)\n  (:start . 287) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 299) (:start . 298)\n  (:id . 93)))@@@1@52@((:hcues ((:id . :x7.208.1) (:span 200 215)))\n (:hscopes ((:id . :x7.208.1) (:span 200 298)))\n (:identifiers (:sid . :s7.208) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102337@unknown@formal@none@1@S@Expression of ADGF-A only in the lymph glands is sufficient to fully rescue the mutant phenotype, indicating that the hemocytes within the lymph glands play a major role in regulation of adenosine levels in the hemolymph.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 45)\n  (:start . 39) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 59)\n  (:start . 49) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 96)\n  (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "indicate") (:form . "indicating") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 113) (:start . 109)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 117) (:start . 114)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 127)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 64))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 144)\n  (:start . 139) (:id . 65))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 151)\n  (:start . 145) (:id . 66))\n ((:tag . "VBP") (:stem . "play") (:form . "play") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 158) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 164)\n  (:start . 159) (:id . 69))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 169) (:start . 165)\n  (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 172) (:start . 170)\n  (:id . 71))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 183)\n  (:start . 173) (:id . 72))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 186) (:start . 184)\n  (:id . 73))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 196)\n  (:start . 187) (:id . 74))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 203)\n  (:start . 197) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 210) (:start . 207)\n  (:id . 77))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 220)\n  (:start . 211) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x7.209.1) (:span 98 113)))\n (:hscopes ((:id . :x7.209.1) (:span 98 220)))\n (:identifiers (:sid . :s7.209) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102338@unknown@formal@none@1@S@A similar regulatory role has also been attributed to blood cells in humans [5].@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 20)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "blood") (:form . "blood") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 68) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 77) (:start . 76)\n  (:id . 55))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 79) (:start . 78)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s7.210) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102340@unknown@formal@none@1@S@However, ADGF-A behaves as a soluble growth factor and could be released from the lymph gland to activate targets elsewhere in the larval body.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 15)\n  (:start . 9) (:id . 44))\n ((:tag . "VBZ") (:stem . "behave") (:form . "behaves") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 28) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 36)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 50)\n  (:start . 44) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 60) (:start . 55)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 72)\n  (:start . 64) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 77) (:start . 73)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 93) (:start . 88)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 59))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 105)\n  (:start . 97) (:id . 60))\n ((:tag . "NNS") (:stem . "target") (:form . "targets") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "RB") (:stem . "elsewhere") (:form . "elsewhere") (:end . 123)\n  (:start . 114) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 137)\n  (:start . 131) (:id . 65))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x7.212.1) (:span 55 60)))\n (:hscopes ((:id . :x7.212.1) (:span 55 142)))\n (:identifiers (:sid . :s7.212) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102341@unknown@formal@none@1@S@Our results show that ADGF-A functions by limiting the level of extracellular adenosine, and in this way the protein could have a systemic function even if it were restricted to its tissue of origin.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "result") (:form . "results") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 38)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "limit") (:form . "limiting") (:end . 50)\n  (:start . 42) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "extracellular") (:form . "extracellular")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 87)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 116)\n  (:start . 109) (:id . 61))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 129) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 147)\n  (:start . 139) (:id . 66))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 152) (:start . 148)\n  (:id . 67))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 155) (:start . 153)\n  (:id . 68))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 163) (:start . 159)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "restricted") (:form . "restricted") (:end . 174)\n  (:start . 164) (:id . 71))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 72))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 181) (:start . 178)\n  (:id . 73))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 188)\n  (:start . 182) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 75))\n ((:tag . "NN") (:stem . "origin") (:form . "origin") (:end . 198)\n  (:start . 192) (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 199) (:start . 198)\n  (:id . 77)))@@@1@36@((:hcues ((:id . :x7.213.1) (:span 117 122)))\n (:hscopes ((:id . :x7.213.1) (:span 117 198)))\n (:identifiers (:sid . :s7.213) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102342@unknown@formal@none@1@S@Although our tests did not exclude a role for ADGF-A in circulating hemocytes (which constitute a separate lineage from the lymph gland hemocytes [20]), we showed that expression of ADGF-A in circulating hemocytes is not required for rescue of the adgf-a mutant phenotype, since e33C-Gal4/UAS-ADGF-A?which expresses ADGF-A in the lymph gland but not in circulating hemocytes?fully rescued the phenotype.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "test") (:form . "tests") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 22) (:start . 19)\n  (:id . 45))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "VB") (:stem . "exclude") (:form . 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5102343@unknown@formal@none@1@S@ADGF-A Is Involved in Hemocyte Differentiation in the Lymph Glands@(((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "Is") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "involve") (:form . "Involved") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocyte") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "NNP") (:stem . "Differentiation") (:form . "Differentiation")\n  (:end . 46) (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Lymph") (:form . "Lymph") (:end . 59) (:start . 54)\n  (:id . 50))\n ((:tag . "NNPS") (:stem . "Glands") (:form . "Glands") (:end . 66)\n  (:start . 60) (:id . 51)))@@@1@10@((:identifiers (:sid . :s7.215) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102344@unknown@formal@none@1@S@Late third-instar larvae homozygous for the adgf-a mutation contain, on average, seven times more hemocytes in circulation than wild-type larvae, and most of these cells show strong adhesive properties compared to normal larval plasmatocytes, which remain rounded after settling down on the substrate.@(((:tag . "JJ") (:stem . "late") (:form . "Late") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 17)\n  (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 24)\n  (:start . 18) (:id . 44))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 35)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . 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5102345@unknown@formal@none@1@S@Although these cells share other characteristics with plasmatocytes, they are normally not seen in circulation until they are released from the lymph glands at the onset of metamorphosis under the regulation of ecdysone to serve as phagocytes for histolysing tissues during metamorphosis—thus, they are referred to as pupal macrophages [19].@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 32) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "characteristic") (:form . "characteristics")\n  (:end . 48) (:start . 33) (:id . 47))\n ((:tag . "IN") (:stem . 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5102346@unknown@formal@none@1@S@In agreement with the presence of these cells in circulation, at least the first lobes of the lymph glands are usually completely dispersed in late third-instar mutant larvae.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 33) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 45) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NN") (:stem . "circulation") (:form . "circulation") (:end . 60)\n  (:start . 49) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 70) (:start . 65)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "lobe") (:form . "lobes") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 93) (:start . 90)\n  (:id . 59))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 99) (:start . 94)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 106)\n  (:start . 100) (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 118)\n  (:start . 111) (:id . 63))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 129)\n  (:start . 119) (:id . 64))\n ((:tag . "VBN") (:stem . "disperse") (:form . "dispersed") (:end . 139)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 147) (:start . 143)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 160)\n  (:start . 148) (:id . 68))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 167)\n  (:start . 161) (:id . 69))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 174)\n  (:start . 168) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s7.218) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102347@unknown@formal@none@1@S@This indication of precocious metamorphic changes [36] in the mutant is further supported by the finding that hemocytes aggregate in a segmental pattern in early rather than late third instar (see Figure 4H–4J), and that the hemocytes lose expression of Hemolectin in late third-instar larvae rather than at the onset of metamorphosis (see Figure 4G) [21].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "indication") (:form . "indication") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "JJ") (:stem . "metamorphic") (:form . "metamorphic") (:end . 41)\n  (:start . 30) (:id . 46))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . 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5102348@unknown@formal@none@1@S@Recent studies show that the Toll signaling pathway, which is already known to be involved in the control of innate immunity of both Drosophila and mammals [34], may also be involved in the control of hemocyte differentiation in the Drosophila larva.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 14)\n  (:start . 7) (:id . 43))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 19) (:start . 15)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 43)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 61) (:start . 59)\n  (:id . 52))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 69)\n  (:start . 62) (:id . 53))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 90)\n  (:start . 82) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 59))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "innate") (:form . "innate") (:end . 115)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "immunity") (:form . "immunity") (:end . 124)\n  (:start . 116) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 143)\n  (:start . 133) (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 155)\n  (:start . 148) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 157) (:start . 156)\n  (:id . 69))\n ((:tag . "CD") (:stem . "34") (:form . "34") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 160) (:start . 159)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 165) (:start . 162)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 170) (:start . 166)\n  (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 173) (:start . 171)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 182)\n  (:start . 174) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 185) (:start . 183)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 78))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 197)\n  (:start . 190) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 200) (:start . 198)\n  (:id . 80))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 209)\n  (:start . 201) (:id . 81))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 225) (:start . 210) (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 83))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 243)\n  (:start . 233) (:id . 85))\n ((:tag . "NN") (:stem . "larva") (:form . "larva") (:end . 249)\n  (:start . 244) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 250) (:start . 249)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x7.220.1) (:span 162 165)))\n (:hscopes ((:id . :x7.220.1) (:span 25 249)))\n (:identifiers (:sid . :s7.220) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102350@unknown@formal@none@1@S@Our work also shows that forced expression of the ADGF-A gene can rescue the effects of overactive Toll signaling, suggesting that ADGF-A might function downstream of Toll signaling to control its effects.@(((:tag . "PRP$") (:stem . "our") (:form . "Our") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 24) (:start . 20)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "force") (:form . "forced") (:end . 31)\n  (:start . 25) (:id . 47))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "VB") (:stem . "rescue") (:form . "rescue") (:end . 72)\n  (:start . 66) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 84)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "overactive") (:form . "overactive") (:end . 98)\n  (:start . 88) (:id . 58))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 103) (:start . 99)\n  (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 113)\n  (:start . 104) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 125)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 130) (:start . 126)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 137)\n  (:start . 131) (:id . 64))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 143)\n  (:start . 138) (:id . 65))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 152)\n  (:start . 144) (:id . 66))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 171) (:start . 167)\n  (:id . 69))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 181)\n  (:start . 172) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 184) (:start . 182)\n  (:id . 71))\n ((:tag . "VB") (:stem . "control") (:form . "control") (:end . 192)\n  (:start . 185) (:id . 72))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 196) (:start . 193)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 204)\n  (:start . 197) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 75)))@@@1@34@((:hcues ((:id . :x7.222.1) (:span 138 143))\n  ((:id . :x7.222.2) (:span 115 125)))\n (:hscopes ((:id . :x7.222.1) (:span 138 204))\n  ((:id . :x7.222.2) (:span 115 204)))\n (:identifiers (:sid . :s7.222) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102351@unknown@formal@none@1@S@This conclusion is consistent with the existence of a putative binding site for Dorsal (one of two known effectors of Toll signaling) in the ADGF-A promoter (Figure 9).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "conclusion") (:form . "conclusion") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 34) (:start . 30)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Dorsal") (:form . "Dorsal") (:end . 86)\n  (:start . 80) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 88) (:start . 87)\n  (:id . 56))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 98) (:start . 95)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 104) (:start . 99)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "effector") (:form . "effectors") (:end . 114)\n  (:start . 105) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 122) (:start . 118)\n  (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 132)\n  (:start . 123) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 147)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 156)\n  (:start . 148) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 158) (:start . 157)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 164)\n  (:start . 158) (:id . 71))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 166) (:start . 165)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 167) (:start . 166)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.223) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102352@unknown@formal@none@1@S@It will be important to explore this connection further, since recent studies suggest an interaction between adenosine signaling and the NF-?B signaling pathway, which is the mammalian counterpart of the Toll pathway [37].@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "VB") (:stem . "explore") (:form . "explore") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "connection") (:form . "connection") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 55)\n  (:start . 48) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 88) (:start . 86)\n  (:id . 56))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 100)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 118)\n  (:start . 109) (:id . 59))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 128)\n  (:start . 119) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 132) (:start . 129)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "NF-?B") (:form . "NF-?B") (:end . 142)\n  (:start . 137) (:id . 63))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 152)\n  (:start . 143) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 160)\n  (:start . 153) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 66))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 170) (:start . 168)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 184)\n  (:start . 175) (:id . 70))\n ((:tag . "NN") (:stem . "counterpart") (:form . "counterpart") (:end . 196)\n  (:start . 185) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 199) (:start . 197)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 208) (:start . 204)\n  (:id . 74))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 218) (:start . 217)\n  (:id . 76))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 220) (:start . 218)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 221) (:start . 220)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x7.224.1) (:span 78 85)))\n (:hscopes ((:id . :x7.224.1) (:span 78 216)))\n (:identifiers (:sid . :s7.224) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102353@unknown@formal@none@1@S@Schematic Map of the ADGF-A Gene with Promoter Analysis@(((:tag . "JJ") (:stem . "schematic") (:form . "Schematic") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Map") (:form . "Map") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "NNP") (:stem . "Gene") (:form . "Gene") (:end . 32) (:start . 28)\n  (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 37) (:start . 33)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Promoter") (:form . "Promoter") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "NNP") (:stem . "Analysis") (:form . "Analysis") (:end . 55)\n  (:start . 47) (:id . 50)))@@@1@9@((:identifiers (:sid . :s7.225) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102354@unknown@formal@none@1@S@The ADGF-A gene contains four exons and two transcriptional starts [17,47].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 29) (:start . 25)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "exon") (:form . "exons") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 59) (:start . 44) (:id . 50))\n ((:tag . "NNS") (:stem . "start") (:form . "starts") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "CD") (:stem . "17,47") (:form . "17,47") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.226) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102355@unknown@formal@none@1@S@We analyzed sequences preceding both transcriptional starts for the presence of known transcriptional factor binding sites using the software program Gene2Promoter (Genomatix Software GmbH).@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "analyze") (:form . "analyzed") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 21)\n  (:start . 12) (:id . 44))\n ((:tag . "VBG") (:stem . "precede") (:form . "preceding") (:end . 31)\n  (:start . 22) (:id . 45))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 52) (:start . 37) (:id . 47))\n ((:tag . "NNS") (:stem . "start") (:form . "starts") (:end . 59)\n  (:start . 53) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 63) (:start . 60)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 76)\n  (:start . 68) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 85) (:start . 80)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "transcriptional") (:form . "transcriptional")\n  (:end . 101) (:start . 86) (:id . 54))\n ((:tag . "NN") (:stem . "factor") (:form . "factor") (:end . 108)\n  (:start . 102) (:id . 55))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 116)\n  (:start . 109) (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 122)\n  (:start . 117) (:id . 57))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 128) (:start . 123)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 132) (:start . 129)\n  (:id . 59))\n ((:tag . "NN") (:stem . "software") (:form . "software") (:end . 141)\n  (:start . 133) (:id . 60))\n ((:tag . "NN") (:stem . "program") (:form . "program") (:end . 149)\n  (:start . 142) (:id . 61))\n ((:tag . "NNP") (:stem . "Gene2Promoter") (:form . "Gene2Promoter")\n  (:end . 163) (:start . 150) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Genomatix") (:form . "Genomatix") (:end . 174)\n  (:start . 165) (:id . 64))\n ((:tag . "NNP") (:stem . "Software") (:form . "Software") (:end . 183)\n  (:start . 175) (:id . 65))\n ((:tag . "NNP") (:stem . "GmbH") (:form . "GmbH") (:end . 188) (:start . 184)\n  (:id . 66))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 189) (:start . 188)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.227) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102356@unknown@formal@none@1@S@Selected sites are represented by color bars in approximate positions of promoter regions.@(((:tag . "VBN") (:stem . "select") (:form . "Selected") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 14) (:start . 9)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "represent") (:form . "represented") (:end . 30)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "NN") (:stem . "color") (:form . "color") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "bar") (:form . "bars") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "approximate") (:form . "approximate") (:end . 59)\n  (:start . 48) (:id . 50))\n ((:tag . "NNS") (:stem . "position") (:form . "positions") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 81)\n  (:start . 73) (:id . 53))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 90) (:start . 89)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.228) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102357@unknown@formal@none@1@S@The legend under the sequence show the names of transcription factors binding to matching colored binding sites.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "legend") (:form . "legend") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBP") (:stem . "show") (:form . "show") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "name") (:form . "names") (:end . 44) (:start . 39)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 61) (:start . 48) (:id . 51))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 69)\n  (:start . 62) (:id . 52))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "match") (:form . "matching") (:end . 89)\n  (:start . 81) (:id . 55))\n ((:tag . "VBN") (:stem . "color") (:form . "colored") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 105)\n  (:start . 98) (:id . 57))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 112) (:start . 111)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.229) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102358@unknown@formal@none@1@S@Precocious Fat-Body Disintegration Caused by Mutant Hemocytes@(((:tag . "JJ") (:stem . "precocious") (:form . "Precocious") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "fat-body") (:form . "Fat-Body") (:end . 19)\n  (:start . 11) (:id . 43))\n ((:tag . "NNP") (:stem . "Disintegration") (:form . "Disintegration")\n  (:end . 34) (:start . 20) (:id . 44))\n ((:tag . "VBN") (:stem . "cause") (:form . "Caused") (:end . 41)\n  (:start . 35) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 44) (:start . 42)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 51)\n  (:start . 45) (:id . 47))\n ((:tag . "NNPS") (:stem . "Hemocyte") (:form . "Hemocytes") (:end . 61)\n  (:start . 52) (:id . 48)))@@@1@7@((:identifiers (:sid . :s7.230) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102360@unknown@formal@none@1@S@Furthermore, our study of this mutant provides strong evidence that the fat body disintegration is promoted by the action of hemocytes.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 22) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 30) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "strong") (:form . "strong") (:end . 53)\n  (:start . 47) (:id . 50))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 80) (:start . 76)\n  (:id . 55))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 95) (:start . 81) (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 98) (:start . 96)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "promote") (:form . "promoted") (:end . 107)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "NN") (:stem . "action") (:form . "action") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s7.232) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102361@unknown@formal@none@1@S@Fat body disintegration was significantly suppressed when the hemocyte number was reduced using the l(3)hem1 mutation [26], and fully blocked by the croquemort (crq) mutation [27] which affects a CD36-related receptor (Croquemort) expressed on macrophages and required in phagocytosis of apoptotic cells.@(((:tag . "NNP") (:stem . "Fat") (:form . "Fat") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 23) (:start . 9) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "VBN") (:stem . "suppress") (:form . "suppressed") (:end . 52)\n  (:start . 42) (:id . 47))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 57) (:start . 53)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 49))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 70)\n  (:start . 62) (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 77)\n  (:start . 71) (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 89)\n  (:start . 82) (:id . 53))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 95) (:start . 90)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "CD") (:stem . "l(3)hem1") (:form . "l(3)hem1") (:end . 108)\n  (:start . 100) (:id . 56))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 117)\n  (:start . 109) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 119) (:start . 118)\n  (:id . 58))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 121) (:start . 119)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 62))\n ((:tag . "RB") (:stem . "fully") (:form . "fully") (:end . 133)\n  (:start . 128) (:id . 63))\n ((:tag . "VBN") (:stem . "block") (:form . "blocked") (:end . 141)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 148) (:start . 145)\n  (:id . 66))\n ((:tag . "NN") (:stem . "croquemort") (:form . "croquemort") (:end . 159)\n  (:start . 149) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 161) (:start . 160)\n  (:id . 68))\n ((:tag . "NN") (:stem . "crq") (:form . "crq") (:end . 164) (:start . 161)\n  (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 165) (:start . 164)\n  (:id . 70))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 174)\n  (:start . 166) (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 176) (:start . 175)\n  (:id . 72))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 178) (:start . 176)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 185)\n  (:start . 180) (:id . 75))\n ((:tag . "VBZ") (:stem . "affect") (:form . "affects") (:end . 193)\n  (:start . 186) (:id . 76))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 195) (:start . 194)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "cd36-related") (:form . "CD36-related") (:end . 208)\n  (:start . 196) (:id . 78))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 217)\n  (:start . 209) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 219) (:start . 218)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "Croquemort") (:form . "Croquemort") (:end . 229)\n  (:start . 219) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 230) (:start . 229)\n  (:id . 82))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 240)\n  (:start . 231) (:id . 83))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 243) (:start . 241)\n  (:id . 84))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 255)\n  (:start . 244) (:id . 85))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 259) (:start . 256)\n  (:id . 86))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 268)\n  (:start . 260) (:id . 87))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 271) (:start . 269)\n  (:id . 88))\n ((:tag . "NN") (:stem . "phagocytosis") (:form . "phagocytosis") (:end . 284)\n  (:start . 272) (:id . 89))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 287) (:start . 285)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 297)\n  (:start . 288) (:id . 91))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 303)\n  (:start . 298) (:id . 92))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 304) (:start . 303)\n  (:id . 93)))@@@1@52@((:identifiers (:sid . :s7.233) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102362@unknown@formal@none@1@S@Human CD36 is a scavenger receptor which, in combination with the macrophage vitronectin receptor and thrombospondin, binds apoptotic cells.@(((:tag . "JJ") (:stem . "human") (:form . "Human") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "CD36") (:form . "CD36") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 25)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 56)\n  (:start . 45) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 76)\n  (:start . 66) (:id . 54))\n ((:tag . "NN") (:stem . "vitronectin") (:form . "vitronectin") (:end . 88)\n  (:start . 77) (:id . 55))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thrombospondin") (:form . "thrombospondin")\n  (:end . 116) (:start . 102) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 117) (:start . 116)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 133)\n  (:start . 124) (:id . 61))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 139)\n  (:start . 134) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 140) (:start . 139)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.234) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102363@unknown@formal@none@1@S@A similar role of Croquemort for removing histolysing tissues during Drosophila metamorphosis has not yet been tested, but seems likely since the crq mutant used in this study (crqKG01679) is lethal in pupae.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Croquemort") (:form . "Croquemort") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "remove") (:form . "removing") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "VBG") (:stem . "histolyse") (:form . "histolysing") (:end . 53)\n  (:start . 42) (:id . 49))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 68)\n  (:start . 62) (:id . 51))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 79)\n  (:start . 69) (:id . 52))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 93) (:start . 80) (:id . 53))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 97) (:start . 94)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 101) (:start . 98)\n  (:id . 55))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 105) (:start . 102)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 110) (:start . 106)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "test") (:form . "tested") (:end . 117)\n  (:start . 111) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 59))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 122) (:start . 119)\n  (:id . 60))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 128)\n  (:start . 123) (:id . 61))\n ((:tag . "JJ") (:stem . "likely") (:form . "likely") (:end . 135)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 141)\n  (:start . 136) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "NN") (:stem . "crq") (:form . "crq") (:end . 149) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 156)\n  (:start . 150) (:id . 66))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 161) (:start . 157)\n  (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 169) (:start . 165)\n  (:id . 69))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 175)\n  (:start . 170) (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 177) (:start . 176)\n  (:id . 71))\n ((:tag . "NN") (:stem . "crqkg01679") (:form . "crqKG01679") (:end . 187)\n  (:start . 177) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 188) (:start . 187)\n  (:id . 73))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 198)\n  (:start . 192) (:id . 75))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 201) (:start . 199)\n  (:id . 76))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 207)\n  (:start . 202) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 208) (:start . 207)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x7.235.1) (:span 129 135))\n  ((:id . :x7.235.2) (:span 123 128)))\n (:ncues ((:id . :x7.235.3) (:span 98 101)))\n (:hscopes ((:id . :x7.235.1) (:span 129 135))\n  ((:id . :x7.235.2) (:span 123 135)))\n (:nscopes ((:id . :x7.235.3) (:span 0 117)))\n (:identifiers (:sid . :s7.235) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102364@unknown@formal@none@1@S@The idea that hemocytes are involved in fat body dissociation in Drosophila is further supported by work on the flesh fly Sarcophaga.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 23)\n  (:start . 14) (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 48) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "dissociation") (:form . "dissociation") (:end . 61)\n  (:start . 49) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 86)\n  (:start . 79) (:id . 55))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 96)\n  (:start . 87) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 104) (:start . 100)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "flesh") (:form . "flesh") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Sarcophaga") (:form . "Sarcophaga") (:end . 132)\n  (:start . 122) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x7.236.1) (:span 4 8)))\n (:hscopes ((:id . :x7.236.1) (:span 4 75)))\n (:identifiers (:sid . :s7.236) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102365@unknown@formal@none@1@S@Natori's group showed that proteinase cathepsin B was released from pupal hemocytes when they interacted with the fat body, and that this enzyme digested the basement membrane of the fat body, causing the tissue to dissociate [38,39].@(((:tag . "NNP") (:stem . "Natori") (:form . "Natori") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 21) (:start . 15)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "proteinase") (:form . "proteinase") (:end . 37)\n  (:start . 27) (:id . 47))\n ((:tag . "NN") (:stem . "cathepsin") (:form . "cathepsin") (:end . 47)\n  (:start . 38) (:id . 48))\n ((:tag . "NNP") (:stem . "B") (:form . "B") (:end . 49) (:start . 48)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 62)\n  (:start . 54) (:id . 51))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 73) (:start . 68)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 83)\n  (:start . 74) (:id . 54))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "interact") (:form . "interacted") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 109) (:start . 105)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 117) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 122) (:start . 118)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 137) (:start . 133)\n  (:id . 65))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 144)\n  (:start . 138) (:id . 66))\n ((:tag . "VBD") (:stem . "digest") (:form . "digested") (:end . 153)\n  (:start . 145) (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 68))\n ((:tag . "NN") (:stem . "basement") (:form . "basement") (:end . 166)\n  (:start . 158) (:id . 69))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 175)\n  (:start . 167) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 182) (:start . 179)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 186) (:start . 183)\n  (:id . 73))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 191) (:start . 187)\n  (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 192) (:start . 191)\n  (:id . 75))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 200)\n  (:start . 193) (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 204) (:start . 201)\n  (:id . 77))\n ((:tag . "NN") (:stem . "tissue") (:form . "tissue") (:end . 211)\n  (:start . 205) (:id . 78))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 214) (:start . 212)\n  (:id . 79))\n ((:tag . "VB") (:stem . "dissociate") (:form . "dissociate") (:end . 225)\n  (:start . 215) (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 227) (:start . 226)\n  (:id . 81))\n ((:tag . "CD") (:stem . "38,39") (:form . "38,39") (:end . 232)\n  (:start . 227) (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 233) (:start . 232)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 234) (:start . 233)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s7.237) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102366@unknown@formal@none@1@S@They also showed that the interaction of hemocytes with the fat body is mediated by a 120-kDa membrane protein localized specifically on pupal hemocytes [40].@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 16) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 37)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 68) (:start . 64)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 80)\n  (:start . 72) (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "120-kda") (:form . "120-kDa") (:end . 93)\n  (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 102)\n  (:start . 94) (:id . 59))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 110)\n  (:start . 103) (:id . 60))\n ((:tag . "VBN") (:stem . "localize") (:form . "localized") (:end . 120)\n  (:start . 111) (:id . 61))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 133)\n  (:start . 121) (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 152)\n  (:start . 143) (:id . 65))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 154) (:start . 153)\n  (:id . 66))\n ((:tag . "CD") (:stem . "40") (:form . "40") (:end . 156) (:start . 154)\n  (:id . 67))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.238) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102367@unknown@formal@none@1@S@This protein was suggested to be a scavenger receptor, but it does not seem to be homologous to Drosophila Croquemort (unpublished data).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "suggest") (:form . "suggested") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 34) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 44)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 53)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 58) (:start . 55)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VB") (:stem . "seem") (:form . "seem") (:end . 75) (:start . 71)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 92)\n  (:start . 82) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 106)\n  (:start . 96) (:id . 61))\n ((:tag . "NNP") (:stem . "Croquemort") (:form . "Croquemort") (:end . 117)\n  (:start . 107) (:id . 62))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 130)\n  (:start . 119) (:id . 64))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 135)\n  (:start . 131) (:id . 65))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 137) (:start . 136)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x7.239.2) (:span 71 75)) ((:id . :x7.239.3) (:span 17 26)))\n (:ncues ((:id . :x7.239.1) (:span 67 70)))\n (:hscopes ((:id . :x7.239.2) (:span 59 117))\n  ((:id . :x7.239.3) (:span 0 53)))\n (:nscopes ((:id . :x7.239.1) (:span 59 117)))\n (:identifiers (:sid . :s7.239) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102368@unknown@formal@none@1@S@Work by Franc et al. [27] is consistent with the idea that more than one scavenger receptor is involved in this process.@(((:tag . "NN") (:stem . "work") (:form . "Work") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Franc") (:form . "Franc") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 22) (:start . 21)\n  (:id . 47))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 24) (:start . 22)\n  (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 25) (:start . 24)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 28) (:start . 26)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "consistent") (:form . "consistent") (:end . 39)\n  (:start . 29) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 53))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 53) (:start . 49)\n  (:id . 54))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 58) (:start . 54)\n  (:id . 55))\n ((:tag . "JJR") (:stem . "more") (:form . "more") (:end . 63) (:start . 59)\n  (:id . 56))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 68) (:start . 64)\n  (:id . 57))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 72) (:start . 69)\n  (:id . 58))\n ((:tag . "NN") (:stem . "scavenger") (:form . "scavenger") (:end . 82)\n  (:start . 73) (:id . 59))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 91)\n  (:start . 83) (:id . 60))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 103)\n  (:start . 95) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 111) (:start . 107)\n  (:id . 64))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 119)\n  (:start . 112) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.240) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102370@unknown@formal@none@1@S@The precocious metamorphic changes that appear to occur in response to elevated adenosine in the adgf-a mutant larvae lead to the suggestion that adenosine may act as a regulatory signal for these processes during normal development.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "metamorphic") (:form . "metamorphic") (:end . 26)\n  (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 34)\n  (:start . 27) (:id . 45))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "appear") (:form . "appear") (:end . 46)\n  (:start . 40) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 48))\n ((:tag . "VB") (:stem . "occur") (:form . "occur") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 67)\n  (:start . 59) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "elevate") (:form . "elevated") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 89)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 96) (:start . 93)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 103)\n  (:start . 97) (:id . 57))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 110)\n  (:start . 104) (:id . 58))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 117)\n  (:start . 111) (:id . 59))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 122) (:start . 118)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 125) (:start . 123)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 129) (:start . 126)\n  (:id . 62))\n ((:tag . "NN") (:stem . "suggestion") (:form . "suggestion") (:end . 140)\n  (:start . 130) (:id . 63))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 155)\n  (:start . 146) (:id . 65))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 159) (:start . 156)\n  (:id . 66))\n ((:tag . "VB") (:stem . "act") (:form . "act") (:end . 163) (:start . 160)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 168) (:start . 167)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 179)\n  (:start . 169) (:id . 70))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 186)\n  (:start . 180) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 196)\n  (:start . 191) (:id . 73))\n ((:tag . "NNS") (:stem . "process") (:form . "processes") (:end . 206)\n  (:start . 197) (:id . 74))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 213)\n  (:start . 207) (:id . 75))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 220)\n  (:start . 214) (:id . 76))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 232)\n  (:start . 221) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x7.242.1) (:span 156 159))\n  ((:id . :x7.242.2) (:span 130 140)) ((:id . :x7.242.3) (:span 40 46)))\n (:hscopes ((:id . :x7.242.1) (:span 156 232))\n  ((:id . :x7.242.2) (:span 130 232)) ((:id . :x7.242.3) (:span 35 117)))\n (:identifiers (:sid . :s7.242) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102371@unknown@formal@none@1@S@One possibility is that adenosine acts as a downstream effector of ecdysone-regulated prepupal changes, and that the increase in adenosine concentration is mediated by ecdysone-induced down-regulation of ADGF-A expression.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "ecdysone-regulated") (:form . "ecdysone-regulated")\n  (:end . 85) (:start . 67) (:id . 53))\n ((:tag . "JJ") (:stem . "prepupal") (:form . "prepupal") (:end . 94)\n  (:start . 86) (:id . 54))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 102)\n  (:start . 95) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 112) (:start . 108)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 125)\n  (:start . 117) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 138)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 152) (:start . 139) (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 155) (:start . 153)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 164)\n  (:start . 156) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 167) (:start . 165)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "ecdysone-induced") (:form . "ecdysone-induced")\n  (:end . 184) (:start . 168) (:id . 67))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 200) (:start . 185) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 210)\n  (:start . 204) (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 221)\n  (:start . 211) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 222) (:start . 221)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x7.243.1) (:span 4 15)))\n (:hscopes ((:id . :x7.243.1) (:span 4 221)))\n (:identifiers (:sid . :s7.243) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102372@unknown@formal@none@1@S@This is supported by the presence of multiple sites for ecdysone-inducible transcription regulators in the ADGF-A promoter (Figure 9).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 45)\n  (:start . 37) (:id . 49))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 51) (:start . 46)\n  (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "ecdysone-inducible") (:form . "ecdysone-inducible")\n  (:end . 74) (:start . 56) (:id . 52))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 88) (:start . 75) (:id . 53))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 99)\n  (:start . 89) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 113)\n  (:start . 107) (:id . 57))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 122)\n  (:start . 114) (:id . 58))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 124) (:start . 123)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 130)\n  (:start . 124) (:id . 60))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 132) (:start . 131)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 133) (:start . 132)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.244) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102373@unknown@formal@none@1@S@Adenosine could serve as a signal for macrophage differentiation, and the lack of adenosine deaminase activity due to the adgf-a mutation could cause precocious differentiation of these cells in mutant larvae.@(((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 15) (:start . 10)\n  (:id . 43))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 33)\n  (:start . 27) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 64) (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 78) (:start . 74)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 81) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 91)\n  (:start . 82) (:id . 56))\n ((:tag . "NN") (:stem . "deaminase") (:form . "deaminase") (:end . 101)\n  (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 110)\n  (:start . 102) (:id . 58))\n ((:tag . "IN") (:stem . "due") (:form . "due") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 121) (:start . 118)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 128)\n  (:start . 122) (:id . 62))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 137)\n  (:start . 129) (:id . 63))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . "VB") (:stem . "cause") (:form . "cause") (:end . 149)\n  (:start . 144) (:id . 65))\n ((:tag . "JJ") (:stem . "precocious") (:form . "precocious") (:end . 160)\n  (:start . 150) (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 176) (:start . 161) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 185)\n  (:start . 180) (:id . 69))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 191)\n  (:start . 186) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 194) (:start . 192)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 201)\n  (:start . 195) (:id . 72))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 208)\n  (:start . 202) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x7.245.1) (:span 138 143))\n  ((:id . :x7.245.3) (:span 10 15)))\n (:ncues ((:id . :x7.245.2) (:span 74 78)))\n (:hscopes ((:id . :x7.245.1) (:span 138 208))\n  ((:id . :x7.245.3) (:span 10 64)))\n (:nscopes ((:id . :x7.245.2) (:span 74 110)))\n (:identifiers (:sid . :s7.245) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102374@unknown@formal@none@1@S@We are now carrying out direct tests of the idea that the differentiation of hemocytes in mutant larvae is caused by elevated adenosine.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 19)\n  (:start . 11) (:id . 45))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "direct") (:form . "direct") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . "NNS") (:stem . "test") (:form . "tests") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 50))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 48) (:start . 44)\n  (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 53) (:start . 49)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 73) (:start . 58) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 76) (:start . 74)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 89) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 96)\n  (:start . 90) (:id . 58))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 103)\n  (:start . 97) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 113)\n  (:start . 107) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 125)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 135)\n  (:start . 126) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x7.246.1) (:span 44 48)))\n (:hscopes ((:id . :x7.246.1) (:span 44 135)))\n (:identifiers (:sid . :s7.246) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102375@unknown@formal@none@1@S@If confirmed, this effect would have general significance, since in ADA-deficient mice, inflammatory changes in the lungs include an accumulation of activated alveolar macrophages [41], and this could also be mediated by elevated adenosine.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "confirm") (:form . "confirmed") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 31) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 44)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 57)\n  (:start . 45) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "ada-deficient") (:form . "ADA-deficient")\n  (:end . 81) (:start . 68) (:id . 54))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 86) (:start . 82)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "inflammatory") (:form . "inflammatory") (:end . 100)\n  (:start . 88) (:id . 57))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 108)\n  (:start . 101) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "lung") (:form . "lungs") (:end . 121)\n  (:start . 116) (:id . 61))\n ((:tag . "VBP") (:stem . "include") (:form . "include") (:end . 129)\n  (:start . 122) (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "accumulation") (:form . "accumulation") (:end . 145)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 158)\n  (:start . 149) (:id . 66))\n ((:tag . "JJ") (:stem . "alveolar") (:form . "alveolar") (:end . 167)\n  (:start . 159) (:id . 67))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 179)\n  (:start . 168) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 181) (:start . 180)\n  (:id . 69))\n ((:tag . "CD") (:stem . "41") (:form . "41") (:end . 183) (:start . 181)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 184) (:start . 183)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 185) (:start . 184)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 189) (:start . 186)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 200)\n  (:start . 195) (:id . 75))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 205) (:start . 201)\n  (:id . 76))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 208) (:start . 206)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 217)\n  (:start . 209) (:id . 78))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 220) (:start . 218)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 229)\n  (:start . 221) (:id . 80))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 239)\n  (:start . 230) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x7.247.1) (:span 195 200))\n  ((:id . :x7.247.2) (:span 26 31)))\n (:hscopes ((:id . :x7.247.1) (:span 190 239))\n  ((:id . :x7.247.2) (:span 26 57)))\n (:identifiers (:sid . :s7.247) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102376@unknown@formal@none@1@S@Elevated Adenosine Delays Development and Inhibits Pupariation@(((:tag . "NNP") (:stem . "Elevated") (:form . "Elevated") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 18)\n  (:start . 9) (:id . 43))\n ((:tag . "NNP") (:stem . "Delays") (:form . "Delays") (:end . 25)\n  (:start . 19) (:id . 44))\n ((:tag . "NNP") (:stem . "Development") (:form . "Development") (:end . 37)\n  (:start . 26) (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 41) (:start . 38)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "inhibit") (:form . "Inhibits") (:end . 50)\n  (:start . 42) (:id . 47))\n ((:tag . "NNP") (:stem . "Pupariation") (:form . "Pupariation") (:end . 62)\n  (:start . 51) (:id . 48)))@@@1@7@((:identifiers (:sid . :s7.248) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102377@unknown@formal@none@1@S@The elevated adenosine in the adgf-a mutant larvae leads to precocious changes (hemocyte differentiation and fat body disintegration) resembling those normally occurring at the time of metamorphosis, but it also is associated with an apparently opposite effect, in that it causes a significant delay in progress through the third larval instar and a decrease in the frequency of successful pupariation (formation of the puparium from the larval cuticle), which is one of the earliest steps in metamorphosis.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . 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"at") (:end . 172) (:start . 170)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 67))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 198) (:start . 185) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 199) (:start . 198)\n  (:id . 71))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 203) (:start . 200)\n  (:id . 72))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 206) (:start . 204)\n  (:id . 73))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 211) (:start . 207)\n  (:id . 74))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 214) (:start . 212)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 225)\n  (:start . 215) (:id . 76))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 230) (:start . 226)\n  (:id . 77))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 233) (:start . 231)\n  (:id . 78))\n ((:tag . "RB") (:stem . "apparently") (:form . "apparently") (:end . 244)\n  (:start . 234) (:id . 79))\n ((:tag . "JJ") (:stem . "opposite") (:form . "opposite") (:end . 253)\n  (:start . 245) (:id . 80))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 260)\n  (:start . 254) (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 261) (:start . 260)\n  (:id . 82))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 264) (:start . 262)\n  (:id . 83))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 269) (:start . 265)\n  (:id . 84))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 272) (:start . 270)\n  (:id . 85))\n ((:tag . "VBZ") (:stem . "cause") (:form . 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"instar") (:end . 343)\n  (:start . 337) (:id . 96))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 347) (:start . 344)\n  (:id . 97))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 349) (:start . 348)\n  (:id . 98))\n ((:tag . "NN") (:stem . "decrease") (:form . "decrease") (:end . 358)\n  (:start . 350) (:id . 99))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 361) (:start . 359)\n  (:id . 100))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 365) (:start . 362)\n  (:id . 101))\n ((:tag . "NN") (:stem . "frequency") (:form . "frequency") (:end . 375)\n  (:start . 366) (:id . 102))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 378) (:start . 376)\n  (:id . 103))\n ((:tag . "JJ") (:stem . "successful") (:form . "successful") (:end . 389)\n  (:start . 379) (:id . 104))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 401)\n  (:start . 390) (:id . 105))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 403) (:start . 402)\n  (:id . 106))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 412)\n  (:start . 403) (:id . 107))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 415) (:start . 413)\n  (:id . 108))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 419) (:start . 416)\n  (:id . 109))\n ((:tag . "NN") (:stem . "puparium") (:form . "puparium") (:end . 428)\n  (:start . 420) (:id . 110))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 433) (:start . 429)\n  (:id . 111))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 437) (:start . 434)\n  (:id . 112))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 444)\n  (:start . 438) (:id . 113))\n ((:tag . "NN") (:stem . "cuticle") (:form . "cuticle") (:end . 452)\n  (:start . 445) (:id . 114))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 453) (:start . 452)\n  (:id . 115))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 454) (:start . 453)\n  (:id . 116))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 460)\n  (:start . 455) (:id . 117))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 463) (:start . 461)\n  (:id . 118))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 467) (:start . 464)\n  (:id . 119))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 470) (:start . 468)\n  (:id . 120))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 474) (:start . 471)\n  (:id . 121))\n ((:tag . "JJS") (:stem . "early") (:form . "earliest") (:end . 483)\n  (:start . 475) (:id . 122))\n ((:tag . "NNS") (:stem . "step") (:form . "steps") (:end . 489)\n  (:start . 484) (:id . 123))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 492) (:start . 490)\n  (:id . 124))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 506) (:start . 493) (:id . 125))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 507) (:start . 506)\n  (:id . 126)))@@@1@85@((:hcues ((:id . :x7.249.1) (:span 234 244)))\n (:hscopes ((:id . :x7.249.1) (:span 234 260)))\n (:identifiers (:sid . :s7.249) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102378@unknown@formal@none@1@S@We conclude that the mutation has additional effects on the hormonal regulation of development.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "conclude") (:form . "conclude") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 44)\n  (:start . 34) (:id . 48))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 52)\n  (:start . 45) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "hormonal") (:form . "hormonal") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 79)\n  (:start . 69) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 94)\n  (:start . 83) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 95) (:start . 94)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s7.250) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102380@unknown@formal@none@1@S@This is supported by the fact that pupariation rate and survival of the adgf-a mutant can be significantly improved by expression of transgenic ADGF-A in the ring gland and salivary glands.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 17)\n  (:start . 8) (:id . 44))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 64)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 85)\n  (:start . 79) (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "significantly") (:form . "significantly")\n  (:end . 106) (:start . 93) (:id . 59))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 115)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 129)\n  (:start . 119) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 143)\n  (:start . 133) (:id . 64))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "ADGF-A") (:end . 150)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 162) (:start . 158)\n  (:id . 68))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 168)\n  (:start . 163) (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 172) (:start . 169)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "salivary") (:form . "salivary") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 188)\n  (:start . 182) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x7.252.1) (:span 86 89)))\n (:hscopes ((:id . :x7.252.1) (:span 35 188)))\n (:identifiers (:sid . :s7.252) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102381@unknown@formal@none@1@S@We suggest that this somehow interferes with the regulation of hormone release.@(((:tag . "PRP") (:stem . "we") (:form . "We") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "somehow") (:form . "somehow") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "VBZ") (:stem . "interfere") (:form . "interferes") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 51))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 78)\n  (:start . 71) (:id . 53))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 79) (:start . 78)\n  (:id . 54)))@@@1@13@((:hcues ((:id . :x7.253.1) (:span 3 10)))\n (:hscopes ((:id . :x7.253.1) (:span 3 78)))\n (:identifiers (:sid . :s7.253) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102382@unknown@formal@none@1@S@Other mutants with hormonal dysregulation show delayed larval development and failure to pupariate [42,43].@(((:tag . "JJ") (:stem . "other") (:form . "Other") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mutant") (:form . "mutants") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "hormonal") (:form . "hormonal") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "NN") (:stem . "dysregulation") (:form . "dysregulation")\n  (:end . 41) (:start . 28) (:id . 46))\n ((:tag . "NN") (:stem . "show") (:form . "show") (:end . 46) (:start . 42)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "delay") (:form . "delayed") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 61)\n  (:start . 55) (:id . 49))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 73)\n  (:start . 62) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 51))\n ((:tag . "NN") (:stem . "failure") (:form . "failure") (:end . 85)\n  (:start . 78) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "VB") (:stem . "pupariate") (:form . "pupariate") (:end . 98)\n  (:start . 89) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 100) (:start . 99)\n  (:id . 55))\n ((:tag . "CD") (:stem . "42,43") (:form . "42,43") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 58)))@@@1@17@((:ncues ((:id . :x7.254.1) (:span 78 85)))\n (:nscopes ((:id . :x7.254.1) (:span 78 98)))\n (:identifiers (:sid . :s7.254) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102383@unknown@formal@none@1@S@Presumably the elevated adenosine in the adgf-a mutant blocks the production or release of ecdysone from the ring gland by an unknown mechanism.@(((:tag . "RB") (:stem . "presumably") (:form . "Presumably") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 54)\n  (:start . 48) (:id . 49))\n ((:tag . "VBZ") (:stem . "block") (:form . "blocks") (:end . 61)\n  (:start . 55) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 76)\n  (:start . 66) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 87)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 99)\n  (:start . 91) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 104) (:start . 100)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 113) (:start . 109)\n  (:id . 59))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 125) (:start . 123)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 143)\n  (:start . 134) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x7.255.1) (:span 0 10)))\n (:hscopes ((:id . :x7.255.1) (:span 0 143)))\n (:identifiers (:sid . :s7.255) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102384@unknown@formal@none@1@S@This idea is supported by our finding that both pupariation rate and survival of the adgf-a mutant can also be improved by feeding the mutant larvae with 20E in the diet (see Figure 7A).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "idea") (:form . "idea") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "support") (:form . "supported") (:end . 22)\n  (:start . 13) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "finding") (:form . "finding") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "pupariation") (:form . "pupariation") (:end . 59)\n  (:start . 48) (:id . 51))\n ((:tag . "NN") (:stem . "rate") (:form . "rate") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 91)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 102) (:start . 99)\n  (:id . 59))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 110) (:start . 108)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 119)\n  (:start . 111) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "feed") (:form . "feeding") (:end . 130)\n  (:start . 123) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "mutant") (:form . "mutant") (:end . 141)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "larvae") (:form . "larvae") (:end . 148)\n  (:start . 142) (:id . 67))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 153) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "20e") (:form . "20E") (:end . 157) (:start . 154)\n  (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 164) (:start . 161)\n  (:id . 71))\n ((:tag . "NN") (:stem . "diet") (:form . "diet") (:end . 169) (:start . 165)\n  (:id . 72))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 174) (:start . 171)\n  (:id . 74))\n ((:tag . "NN") (:stem . "figure") (:form . "Figure") (:end . 181)\n  (:start . 175) (:id . 75))\n ((:tag . "NN") (:stem . "7a") (:form . "7A") (:end . 184) (:start . 182)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 185) (:start . 184)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x7.256.1) (:span 99 102)))\n (:hscopes ((:id . :x7.256.1) (:span 43 169)))\n (:identifiers (:sid . :s7.256) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102385@unknown@formal@none@1@S@Thus it is clear that the adgf-a mutant is arrested in development due to an effect of the mutation on hormone production from the ring gland.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 16) (:start . 11)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 39)\n  (:start . 33) (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "arrest") (:form . "arrested") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 66)\n  (:start . 55) (:id . 53))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 76) (:start . 74)\n  (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 83)\n  (:start . 77) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "NN") (:stem . "production") (:form . "production") (:end . 121)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 126) (:start . 122)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 130) (:start . 127)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 141)\n  (:start . 136) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.257) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102386@unknown@formal@none@1@S@The arrest of development in the adgf-a mutants was significantly suppressed by loss of the adenosine receptor caused by the adoR mutation: larvae simply homozygous for adgf-a pupated after two or more days, whereas larvae also homozygous for adoR pupated within 1 d after their heterozygous siblings (see Figure 7A).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . 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5102387@unknown@formal@none@1@S@Therefore, adenosine signaling through the AdoR must play a role in the developmental arrest of the adgf-a mutant, and this is most likely mediated by signaling to the ring gland, where AdoR is expressed (ED, unpublished data).@(((:tag . "RB") (:stem . "therefore") (:form . "Therefore") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 10) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 20)\n  (:start . 11) (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 38)\n  (:start . 31) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 47))\n ((:tag . "NN") (:stem . "ador") (:form . "AdoR") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 57) (:start . 53)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 59) (:start . 58)\n  (:id . 51))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 64) (:start . 60)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 67) (:start . 65)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 85) (:start . 72) (:id . 55))\n ((:tag . "NN") (:stem . "arrest") (:form . "arrest") (:end . 92)\n  (:start . 86) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 106)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 113)\n  (:start . 107) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 118) (:start . 115)\n  (:id . 62))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 123) (:start . 119)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 126) (:start . 124)\n  (:id . 64))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 131) (:start . 127)\n  (:id . 65))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 138)\n  (:start . 132) (:id . 66))\n ((:tag . "VBN") (:stem . "mediate") (:form . "mediated") (:end . 147)\n  (:start . 139) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "signal") (:form . "signaling") (:end . 160)\n  (:start . 151) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 163) (:start . 161)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 167) (:start . 164)\n  (:id . 71))\n ((:tag . "NN") (:stem . "ring") (:form . "ring") (:end . 172) (:start . 168)\n  (:id . 72))\n ((:tag . "NN") (:stem . "gland") (:form . "gland") (:end . 178)\n  (:start . 173) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 179) (:start . 178)\n  (:id . 74))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 185)\n  (:start . 180) (:id . 75))\n ((:tag . "NNP") (:stem . "AdoR") (:form . "AdoR") (:end . 190) (:start . 186)\n  (:id . 76))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 193) (:start . 191)\n  (:id . 77))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 203)\n  (:start . 194) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 205) (:start . 204)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "ed") (:form . "ED") (:end . 207) (:start . 205)\n  (:id . 80))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 208) (:start . 207)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 220)\n  (:start . 209) (:id . 82))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 225)\n  (:start . 221) (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 226) (:start . 225)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 227) (:start . 226)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x7.259.1) (:span 132 138))\n  ((:id . :x7.259.2) (:span 48 52)))\n (:hscopes ((:id . :x7.259.1) (:span 119 207))\n  ((:id . :x7.259.2) (:span 48 113)))\n (:identifiers (:sid . :s7.259) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102388@unknown@formal@none@1@S@The mutation in AdoR does not block macrophage differentiation and fat-body disintegration, so this effect must involve another, as yet uncharacterized mechanism independent of AdoR signaling.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "AdoR") (:form . "AdoR") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "NN") (:stem . "macrophage") (:form . "macrophage") (:end . 46)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 62) (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fat-body") (:form . "fat-body") (:end . 75)\n  (:start . 67) (:id . 52))\n ((:tag . "NN") (:stem . "disintegration") (:form . "disintegration")\n  (:end . 90) (:start . 76) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "NN") (:stem . "effect") (:form . "effect") (:end . 106)\n  (:start . 100) (:id . 57))\n ((:tag . "MD") (:stem . "must") (:form . "must") (:end . 111) (:start . 107)\n  (:id . 58))\n ((:tag . "VB") (:stem . "involve") (:form . "involve") (:end . 119)\n  (:start . 112) (:id . 59))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 127)\n  (:start . 120) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 128) (:start . 127)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 131) (:start . 129)\n  (:id . 62))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 135) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "uncharacterized") (:form . "uncharacterized")\n  (:end . 151) (:start . 136) (:id . 64))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 161)\n  (:start . 152) (:id . 65))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 173)\n  (:start . 162) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "AdoR") (:form . "AdoR") (:end . 181) (:start . 177)\n  (:id . 68))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 191)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x7.260.1) (:span 107 111)))\n (:ncues ((:id . :x7.260.2) (:span 26 29)))\n (:hscopes ((:id . :x7.260.1) (:span 107 191)))\n (:nscopes ((:id . :x7.260.2) (:span 26 90)))\n (:identifiers (:sid . :s7.260) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102390@unknown@formal@none@1@S@However, we cannot exclude the role of elevated deoxyadenosine in these effects.@(((:tag . "RB") (:stem . "however") (:form . "However") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "cannot") (:form . "cannot") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "VB") (:stem . "exclude") (:form . "exclude") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 47)\n  (:start . 39) (:id . 50))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 62) (:start . 48) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "effect") (:form . "effects") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 80) (:start . 79)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x7.262.1) (:span 12 26)))\n (:hscopes ((:id . :x7.262.1) (:span 12 79)))\n (:identifiers (:sid . :s7.262) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102391@unknown@formal@none@1@S@Drosophila, now with the advantage of the well-characterized adgf-a mutant, could serve as an ideal model system in which to investigate this mechanism.@(((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 43))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "well-characterized") (:form . "well-characterized")\n  (:end . 60) (:start . 42) (:id . 50))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "mutant") (:form . "mutant") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 53))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "VB") (:stem . "serve") (:form . "serve") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ideal") (:form . "ideal") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 105)\n  (:start . 100) (:id . 59))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 115) (:start . 113)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 121)\n  (:start . 116) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 124) (:start . 122)\n  (:id . 63))\n ((:tag . "VB") (:stem . "investigate") (:form . "investigate") (:end . 136)\n  (:start . 125) (:id . 64))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 151)\n  (:start . 142) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x7.263.1) (:span 76 81)))\n (:hscopes ((:id . :x7.263.1) (:span 76 151)))\n (:identifiers (:sid . :s7.263) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102392@unknown@formal@none@1@S@Concluding Remarks@(((:tag . "VBG") (:stem . "conclude") (:form . "Concluding") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "remark") (:form . "Remarks") (:end . 18)\n  (:start . 11) (:id . 43)))@@@1@2@((:identifiers (:sid . :s7.264) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102393@unknown@formal@none@1@S@In our previous work using cells cultured in vitro, we showed that, as in mammals, adenosine can block proliferation and/or survival of some Drosophila cell types [16].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "previous") (:form . "previous") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 26) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 32) (:start . 27)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 41)\n  (:start . 33) (:id . 48))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 61) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 70) (:start . 68)\n  (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 81)\n  (:start . 74) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 82) (:start . 81)\n  (:id . 59))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 92)\n  (:start . 83) (:id . 60))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 96) (:start . 93)\n  (:id . 61))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 102) (:start . 97)\n  (:id . 62))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 116) (:start . 103) (:id . 63))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 123)\n  (:start . 117) (:id . 64))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 132)\n  (:start . 124) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 156) (:start . 152)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "type") (:form . "types") (:end . 162)\n  (:start . 157) (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 167) (:start . 166)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 168) (:start . 167)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.265) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102394@unknown@formal@none@1@S@In the present work, we have established a Drosophila model to study altered levels of adenosine and deoxyadenosine in vivo, and we have shown that loss of ADGF-A function causes an increase of these nucleosides in larval hemolymph.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 28) (:start . 24)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "establish") (:form . "established") (:end . 40)\n  (:start . 29) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 42) (:start . 41)\n  (:id . 50))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "study") (:form . "study") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "altered") (:form . "altered") (:end . 76)\n  (:start . 69) (:id . 55))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 83)\n  (:start . 77) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 86) (:start . 84)\n  (:id . 57))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 96)\n  (:start . 87) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 115) (:start . 101) (:id . 60))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 131) (:start . 129)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 136) (:start . 132)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 68))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 152) (:start . 148)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 155) (:start . 153)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 162)\n  (:start . 156) (:id . 71))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 171)\n  (:start . 163) (:id . 72))\n ((:tag . "VBZ") (:stem . "cause") (:form . "causes") (:end . 178)\n  (:start . 172) (:id . 73))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 181) (:start . 179)\n  (:id . 74))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 190)\n  (:start . 182) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 193) (:start . 191)\n  (:id . 76))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 199)\n  (:start . 194) (:id . 77))\n ((:tag . "NNS") (:stem . "nucleoside") (:form . "nucleosides") (:end . 211)\n  (:start . 200) (:id . 78))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 214) (:start . 212)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 221)\n  (:start . 215) (:id . 80))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 231)\n  (:start . 222) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 232) (:start . 231)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s7.266) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102395@unknown@formal@none@1@S@Although the adgf-a mutation leads to larval or pupal death, we have shown that this is not due to the adenosine or deoxyadenosine simply blocking cellular proliferation or survival, as the experiments in vitro would suggest.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "adgf-a") (:form . "adgf-a") (:end . 19)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 44)\n  (:start . 38) (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 53) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 59) (:start . 54)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 74) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 79) (:start . 75)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 84) (:start . 80)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 58))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 91) (:start . 88)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 98) (:start . 96)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 102) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 112)\n  (:start . 103) (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 115) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 130) (:start . 116) (:id . 65))\n ((:tag . "RB") (:stem . "simply") (:form . "simply") (:end . 137)\n  (:start . 131) (:id . 66))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . "NN") (:stem . "proliferation") (:form . "proliferation")\n  (:end . 169) (:start . 156) (:id . 69))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 172) (:start . 170)\n  (:id . 70))\n ((:tag . "NN") (:stem . "survival") (:form . "survival") (:end . 181)\n  (:start . 173) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 182) (:start . 181)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 185) (:start . 183)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 201)\n  (:start . 190) (:id . 75))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 76))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 210)\n  (:start . 205) (:id . 77))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 216)\n  (:start . 211) (:id . 78))\n ((:tag . "VB") (:stem . "suggest") (:form . "suggest") (:end . 224)\n  (:start . 217) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 225) (:start . 224)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x7.267.1) (:span 217 224))\n  ((:id . :x7.267.2) (:span 211 216)))\n (:ncues ((:id . :x7.267.3) (:span 88 91)))\n (:hscopes ((:id . :x7.267.1) (:span 217 224))\n  ((:id . :x7.267.2) (:span 211 224)))\n (:nscopes ((:id . :x7.267.3) (:span 88 181)))\n (:identifiers (:sid . :s7.267) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102396@unknown@formal@none@1@S@Rather, this mutation leads to an increase in number of hemocytes at the end of larval development due to the differentiation and release of hemocytes from the lymph glands.@(((:tag . "RB") (:stem . "rather") (:form . "Rather") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 21)\n  (:start . 13) (:id . 45))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 33) (:start . 31)\n  (:id . 48))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 52)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 65)\n  (:start . 56) (:id . 53))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 68) (:start . 66)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 72) (:start . 69)\n  (:id . 55))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 76) (:start . 73)\n  (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "larval") (:form . "larval") (:end . 86)\n  (:start . 80) (:id . 58))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 98)\n  (:start . 87) (:id . 59))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 102) (:start . 99)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 109) (:start . 106)\n  (:id . 62))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 125) (:start . 110) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 137)\n  (:start . 130) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 140) (:start . 138)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 150)\n  (:start . 141) (:id . 67))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 155) (:start . 151)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 69))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 172)\n  (:start . 166) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 173) (:start . 172)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.268) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102397@unknown@formal@none@1@S@Hemocytes also differentiate and are released from the lymph glands during systemic infection [19].@(((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocytes") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "differentiate") (:form . "differentiate")\n  (:end . 28) (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 32) (:start . 29)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "release") (:form . "released") (:end . 45)\n  (:start . 37) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 74)\n  (:start . 68) (:id . 52))\n ((:tag . "JJ") (:stem . "systemic") (:form . "systemic") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 95) (:start . 94)\n  (:id . 55))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 97) (:start . 95)\n  (:id . 56))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 98) (:start . 97)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s7.269) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102398@unknown@formal@none@1@S@Together with our result suggesting an interaction between Toll signaling and ADGF-A, this leads to the hypothesis that adenosine controls hemocyte differentiation in response to infection, and that it signals through the adenosine receptor to postpone the next developmental step, metamorphosis.@(((:tag . "RB") (:stem . "together") (:form . "Together") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "result") (:form . "result") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 35)\n  (:start . 25) (:id . 46))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 50)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 58)\n  (:start . 51) (:id . 49))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 63) (:start . 59)\n  (:id . 50))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 73)\n  (:start . 64) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 84)\n  (:start . 78) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 90) (:start . 86)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "lead") (:form . "leads") (:end . 96) (:start . 91)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hypothesis") (:form . "hypothesis") (:end . 114)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 129)\n  (:start . 120) (:id . 61))\n ((:tag . "VBZ") (:stem . "control") (:form . "controls") (:end . 138)\n  (:start . 130) (:id . 62))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 147)\n  (:start . 139) (:id . 63))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 163) (:start . 148) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 166) (:start . 164)\n  (:id . 65))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 175)\n  (:start . 167) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 178) (:start . 176)\n  (:id . 67))\n ((:tag . "NN") (:stem . "infection") (:form . "infection") (:end . 188)\n  (:start . 179) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 193) (:start . 190)\n  (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 198) (:start . 194)\n  (:id . 71))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 201) (:start . 199)\n  (:id . 72))\n ((:tag . "VBZ") (:stem . "signal") (:form . "signals") (:end . 209)\n  (:start . 202) (:id . 73))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 217)\n  (:start . 210) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 221) (:start . 218)\n  (:id . 75))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 231)\n  (:start . 222) (:id . 76))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 240)\n  (:start . 232) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 243) (:start . 241)\n  (:id . 78))\n ((:tag . "VB") (:stem . "postpone") (:form . "postpone") (:end . 252)\n  (:start . 244) (:id . 79))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 256) (:start . 253)\n  (:id . 80))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 261) (:start . 257)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 275) (:start . 262) (:id . 82))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 280) (:start . 276)\n  (:id . 83))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 281) (:start . 280)\n  (:id . 84))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 295) (:start . 282) (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 296) (:start . 295)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x7.270.1) (:span 104 114))\n  ((:id . :x7.270.2) (:span 25 35)))\n (:hscopes ((:id . :x7.270.1) (:span 104 295))\n  ((:id . :x7.270.2) (:span 25 84)))\n (:identifiers (:sid . :s7.270) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102400@unknown@formal@none@1@S@A similar process of hemocyte differentiation and release from the lymph glands normally takes place at the onset of metamorphosis, when pupal macrophages remove histolyzing tissues.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hemocyte") (:form . "hemocyte") (:end . 29)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 45) (:start . 30) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 49) (:start . 46)\n  (:id . 48))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 57)\n  (:start . 50) (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 62) (:start . 58)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 51))\n ((:tag . "NN") (:stem . "lymph") (:form . "lymph") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "gland") (:form . "glands") (:end . 79)\n  (:start . 73) (:id . 53))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "VBZ") (:stem . "take") (:form . "takes") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "place") (:form . "place") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 58))\n ((:tag . "NN") (:stem . "onset") (:form . "onset") (:end . 113)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 130) (:start . 117) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 131) (:start . 130)\n  (:id . 62))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 136) (:start . 132)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "pupal") (:form . "pupal") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . "NNS") (:stem . "macrophage") (:form . "macrophages") (:end . 154)\n  (:start . 143) (:id . 65))\n ((:tag . "VBP") (:stem . "remove") (:form . "remove") (:end . 161)\n  (:start . 155) (:id . 66))\n ((:tag . "VBG") (:stem . "histolyze") (:form . "histolyzing") (:end . 173)\n  (:start . 162) (:id . 67))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 181)\n  (:start . 174) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s7.272) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102401@unknown@formal@none@1@S@The ADGF-A promoter contains consensus binding sites for effectors of both Toll and ecdysone signaling.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "NN") (:stem . "consensus") (:form . "consensus") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 56) (:start . 53)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "effector") (:form . "effectors") (:end . 66)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 79) (:start . 75)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 83) (:start . 80)\n  (:id . 54))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 92)\n  (:start . 84) (:id . 55))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s7.273) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102402@unknown@formal@none@1@S@This raises the possibility that adenosine plays a role in the control of metamorphosis as well as in the response to stress.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "raise") (:form . "raises") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 27)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 42)\n  (:start . 33) (:id . 47))\n ((:tag . "VBZ") (:stem . "play") (:form . "plays") (:end . 48) (:start . 43)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 50) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 70)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NN") (:stem . "metamorphosis") (:form . "metamorphosis")\n  (:end . 87) (:start . 74) (:id . 55))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 98) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 114)\n  (:start . 106) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 117) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "stress") (:form . "stress") (:end . 124)\n  (:start . 118) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x7.274.1) (:span 5 27)))\n (:hscopes ((:id . :x7.274.1) (:span 5 124)))\n (:identifiers (:sid . :s7.274) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102403@unknown@formal@none@1@S@Materials and Methods@(((:tag . "NNPS") (:stem . "Material") (:form . "Materials") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNPS") (:stem . "Method") (:form . "Methods") (:end . 21)\n  (:start . 14) (:id . 44)))@@@1@3@((:identifiers (:sid . :s7.275) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102404@unknown@formal@none@1@S@Fly strains and genetics@(((:tag . "RB") (:stem . "fly") (:form . "Fly") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "strain") (:form . "strains") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "genetic") (:form . "genetics") (:end . 24)\n  (:start . 16) (:id . 45)))@@@1@4@((:identifiers (:sid . :s7.276) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102405@unknown@formal@none@1@S@For standard procedures, flies were raised at 25 °C on a standard cornmeal-agar-yeast-molasses diet supplemented with 0.3% Nipagin to retard mold growth.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "procedure") (:form . "procedures") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 24) (:start . 23)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 42)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 48) (:start . 46)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 54) (:start . 52)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 56) (:start . 55)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 65)\n  (:start . 57) (:id . 54))\n ((:tag . "NNS") (:stem . "cornmeal-agar-yeast-molass")\n  (:form . "cornmeal-agar-yeast-molasses") (:end . 94) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "diet") (:form . "diet") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "supplement") (:form . "supplemented") (:end . 112)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 117) (:start . 113)\n  (:id . 58))\n ((:tag . "CD") (:stem . "0.3") (:form . "0.3") (:end . 121) (:start . 118)\n  (:id . 59))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 122) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "nipagin") (:form . "Nipagin") (:end . 130)\n  (:start . 123) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 133) (:start . 131)\n  (:id . 62))\n ((:tag . "VB") (:stem . "retard") (:form . "retard") (:end . 140)\n  (:start . 134) (:id . 63))\n ((:tag . "NN") (:stem . "mold") (:form . "mold") (:end . 145) (:start . 141)\n  (:id . 64))\n ((:tag . "NN") (:stem . "growth") (:form . "growth") (:end . 152)\n  (:start . 146) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.277) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102406@unknown@formal@none@1@S@Oregon flies were used as the wild-type Drosophila strain, but in most cases the y w strain was used as a control since most mutations were carried in the y w background.@(((:tag . "NNP") (:stem . "Oregon") (:form . "Oregon") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 12) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "wild-type") (:form . "wild-type") (:end . 39)\n  (:start . 30) (:id . 48))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 57)\n  (:start . 51) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 51))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 53))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "case") (:form . "cases") (:end . 76) (:start . 71)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 56))\n ((:tag . "NN") (:stem . "y") (:form . "y") (:end . 82) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "w") (:form . "w") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "strain") (:form . "strain") (:end . 91)\n  (:start . 85) (:id . 59))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 95) (:start . 92)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 103) (:start . 101)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 63))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 113)\n  (:start . 106) (:id . 64))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 119)\n  (:start . 114) (:id . 65))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 124) (:start . 120)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 134)\n  (:start . 125) (:id . 67))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 139) (:start . 135)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "carry") (:form . "carried") (:end . 147)\n  (:start . 140) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 71))\n ((:tag . "NN") (:stem . "y") (:form . "y") (:end . 156) (:start . 155)\n  (:id . 72))\n ((:tag . "NN") (:stem . "w") (:form . "w") (:end . 158) (:start . 157)\n  (:id . 73))\n ((:tag . "NN") (:stem . "background") (:form . "background") (:end . 169)\n  (:start . 159) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 170) (:start . 169)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s7.278) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102407@unknown@formal@none@1@S@A mutation in the ADGF-A gene on Chromosome III was obtained as described earlier [17].@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 10)\n  (:start . 2) (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 24)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 29) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 43)\n  (:start . 33) (:id . 49))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "RBR") (:stem . "earlier") (:form . "earlier") (:end . 81)\n  (:start . 74) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 85) (:start . 83)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 87) (:start . 86)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.279) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102408@unknown@formal@none@1@S@In this study, the mutation described as adgf-akarel was used in all experiments and is referred to here as adgf-a.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "study") (:form . "study") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "adgf-akarel") (:form . "adgf-akarel") (:end . 52)\n  (:start . 41) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 61) (:start . 57)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 68) (:start . 65)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 80)\n  (:start . 69) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "refer") (:form . "referred") (:end . 96)\n  (:start . 88) (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "RB") (:stem . "here") (:form . "here") (:end . 104) (:start . 100)\n  (:id . 60))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 107) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "adgf-a") (:form . "adgf-a") (:end . 114)\n  (:start . 108) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.280) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102410@unknown@formal@none@1@S@Transgenic flies carrying HS-ADGF-A,UAS-ADGF-Amyc, and UAS-mutADGF-Amyc construct (see description below) were produced by a modified P-element transformation method [45].@(((:tag . "JJ") (:stem . "transgenic") (:form . "Transgenic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "NNP") (:stem . "HS-ADGF-A,UAS-ADGF-Amyc")\n  (:form . "HS-ADGF-A,UAS-ADGF-Amyc") (:end . 49) (:start . 26) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "UAS-mutADGF-Amyc") (:form . "UAS-mutADGF-Amyc")\n  (:end . 71) (:start . 55) (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 81)\n  (:start . 72) (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 50))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 86) (:start . 83)\n  (:id . 51))\n ((:tag . "NN") (:stem . "description") (:form . "description") (:end . 98)\n  (:start . 87) (:id . 52))\n ((:tag . "IN") (:stem . "below") (:form . "below") (:end . 104) (:start . 99)\n  (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 105) (:start . 104)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 110) (:start . 106)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "produce") (:form . "produced") (:end . 119)\n  (:start . 111) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 133)\n  (:start . 125) (:id . 59))\n ((:tag . "NNP") (:stem . "P-element") (:form . "P-element") (:end . 143)\n  (:start . 134) (:id . 60))\n ((:tag . "NN") (:stem . "transformation") (:form . "transformation")\n  (:end . 158) (:start . 144) (:id . 61))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 165)\n  (:start . 159) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 167) (:start . 166)\n  (:id . 63))\n ((:tag . "CD") (:stem . "45") (:form . "45") (:end . 169) (:start . 167)\n  (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 170) (:start . 169)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.282) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102411@unknown@formal@none@1@S@HS-ADGF-A,UAS-ADGF-Amyc[2A],UAS-ADGF-Amyc[7A],UAS-mutADGF-Amyc[1A], andUAS-mutADGF-Amyc[3B], all insertions on Chromosome II, were isolated and used in this work.@(((:tag . "NNP")\n  (:stem\n   . "HS-ADGF-A,UAS-ADGF-Amyc[2A],UAS-ADGF-Amyc[7A],UAS-mutADGF-Amyc[1A")\n  (:form\n   . "HS-ADGF-A,UAS-ADGF-Amyc[2A],UAS-ADGF-Amyc[7A],UAS-mutADGF-Amyc[1A")\n  (:end . 65) (:start . 0) (:id . 42))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 66) (:start . 65)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "andUAS-mutADGF-Amyc[3B")\n  (:form . "andUAS-mutADGF-Amyc[3B") (:end . 90) (:start . 68) (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 91) (:start . 90)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 47))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 96) (:start . 93)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "insertion") (:form . "insertions") (:end . 107)\n  (:start . 97) (:id . 49))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 110) (:start . 108)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 121)\n  (:start . 111) (:id . 51))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 124) (:start . 122)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 125) (:start . 124)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 130) (:start . 126)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "isolate") (:form . "isolated") (:end . 139)\n  (:start . 131) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 143) (:start . 140)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 148) (:start . 144)\n  (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 58))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 156) (:start . 152)\n  (:id . 59))\n ((:tag . "NN") (:stem . "work") (:form . "work") (:end . 161) (:start . 157)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.283) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102412@unknown@formal@none@1@S@The following markers and mutations were obtained from the Bloomington stock center, accessible at http://fly.bio.indiana.edu/ (stock numbers provided in parentheses): Hml-GFP marker (Hml-Gal4/UAS-GFP) expressing GFP in embryonic and larval hemocytes on Chromosome II (BL-6397), the l(3)hem1 mutation on Chromosome III (BL-6184), and the crqKG01679 mutation in the crq gene on Chromosome II (BL-14900).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "marker") (:form . "markers") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 35)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 40) (:start . 36)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Bloomington") (:form . "Bloomington") (:end . 70)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "stock") (:form . "stock") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "center") (:form . "center") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "accessible") (:form . "accessible") (:end . 95)\n  (:start . 85) (:id . 55))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "http://fly.bio.indiana.edu/")\n  (:form . "http://fly.bio.indiana.edu/") (:end . 126) (:start . 99)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 58))\n ((:tag . "NN") (:stem . "stock") (:form . "stock") (:end . 133)\n  (:start . 128) (:id . 59))\n ((:tag . "NNS") (:stem . "number") (:form . "numbers") (:end . 141)\n  (:start . 134) (:id . 60))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 150)\n  (:start . 142) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "parenthesis") (:form . "parentheses") (:end . 165)\n  (:start . 154) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 64))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 167) (:start . 166)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Hml-GFP") (:form . "Hml-GFP") (:end . 175)\n  (:start . 168) (:id . 66))\n ((:tag . "NN") (:stem . "marker") (:form . 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"mutation") (:end . 300)\n  (:start . 292) (:id . 87))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 303) (:start . 301)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 314)\n  (:start . 304) (:id . 89))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 318) (:start . 315)\n  (:id . 90))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 320) (:start . 319)\n  (:id . 91))\n ((:tag . "NNP") (:stem . "BL-6184") (:form . "BL-6184") (:end . 327)\n  (:start . 320) (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 328) (:start . 327)\n  (:id . 93))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 329) (:start . 328)\n  (:id . 94))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 333) (:start . 330)\n  (:id . 95))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 337) (:start . 334)\n  (:id . 96))\n ((:tag . "NN") (:stem . "crqkg01679") (:form . 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"BL-14900") (:end . 400)\n  (:start . 392) (:id . 107))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 401) (:start . 400)\n  (:id . 108))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 402) (:start . 401)\n  (:id . 109)))@@@1@68@((:identifiers (:sid . :s7.284) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102413@unknown@formal@none@1@S@Mutants in Toll signaling pathway were obtained from Dr. S. Govind: cactE8,cactIIIG, and cactD13 mutations in the cact gene on Chromosome II.@(((:tag . "NNPS") (:stem . "Mutant") (:form . "Mutants") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Toll") (:form . "Toll") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 47)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 52) (:start . 48)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Dr.") (:form . "Dr.") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "S.") (:form . "S.") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Govind") (:form . "Govind") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 67) (:start . 66)\n  (:id . 53))\n ((:tag . "CD") (:stem . "cactE8,cactIIIG") (:form . "cactE8,cactIIIG")\n  (:end . 83) (:start . 68) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cactd13") (:form . "cactD13") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cact") (:form . "cact") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 123) (:start . 119)\n  (:id . 62))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 137)\n  (:start . 127) (:id . 64))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.285) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102414@unknown@formal@none@1@S@The Gal4/UAS [18] system was used for protein misexpression.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Gal4/UAS") (:form . "Gal4/UAS") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "NN") (:stem . "misexpression") (:form . "misexpression")\n  (:end . 59) (:start . 46) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.286) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102415@unknown@formal@none@1@S@The following were obtained from the Bloomington stock center (stock numbers in parenthesis): Cg-Gal4 on Chromosome II (BL-7011), Pw+mW.hs=GawB5015 on II (BL-2721), Pw+mW.hs=GawBc564 on II (BL-6982), Pw+mW.hs=GawBT110 on II (BL-6998), Hml-Gal4 on II (BL-6396), Dot-Gal443A on X (BL-6903), Dot-Gal411C on II (BL-6902), and Lsp2-Gal4 (BL-6357) on III.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Bloomington") (:form . 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"(") (:end . 251) (:start . 250)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "BL-6396") (:form . "BL-6396") (:end . 258)\n  (:start . 251) (:id . 91))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 259) (:start . 258)\n  (:id . 92))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 260) (:start . 259)\n  (:id . 93))\n ((:tag . "NNP") (:stem . "Dot-Gal443A") (:form . "Dot-Gal443A") (:end . 272)\n  (:start . 261) (:id . 94))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 275) (:start . 273)\n  (:id . 95))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 277) (:start . 276)\n  (:id . 96))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 279) (:start . 278)\n  (:id . 97))\n ((:tag . "NNP") (:stem . "BL-6903") (:form . "BL-6903") (:end . 286)\n  (:start . 279) (:id . 98))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 287) (:start . 286)\n  (:id . 99))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 288) (:start . 287)\n  (:id . 100))\n ((:tag . "NNP") (:stem . "Dot-Gal411C") (:form . "Dot-Gal411C") (:end . 300)\n  (:start . 289) (:id . 101))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 303) (:start . 301)\n  (:id . 102))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 306) (:start . 304)\n  (:id . 103))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 308) (:start . 307)\n  (:id . 104))\n ((:tag . "NNP") (:stem . "BL-6902") (:form . "BL-6902") (:end . 315)\n  (:start . 308) (:id . 105))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 316) (:start . 315)\n  (:id . 106))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 317) (:start . 316)\n  (:id . 107))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 321) (:start . 318)\n  (:id . 108))\n ((:tag . "NNP") (:stem . "Lsp2-Gal4") (:form . "Lsp2-Gal4") (:end . 331)\n  (:start . 322) (:id . 109))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 333) (:start . 332)\n  (:id . 110))\n ((:tag . "NNP") (:stem . "BL-6357") (:form . "BL-6357") (:end . 340)\n  (:start . 333) (:id . 111))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 341) (:start . 340)\n  (:id . 112))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 344) (:start . 342)\n  (:id . 113))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 348) (:start . 345)\n  (:id . 114))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 349) (:start . 348)\n  (:id . 115)))@@@1@74@((:identifiers (:sid . :s7.287) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102416@unknown@formal@none@1@S@The Pen2.4-GAL4e33C lethal insertion on Chromosome III was obtained from Dr. N. Perrimon's lab, and the Dmef2-Gal4 driver on II from Dr. A. Michelson.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Pen2.4-GAL4e33C") (:form . "Pen2.4-GAL4e33C")\n  (:end . 19) (:start . 4) (:id . 43))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 26)\n  (:start . 20) (:id . 44))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 36)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 50)\n  (:start . 40) (:id . 47))\n ((:tag . "CD") (:stem . "iii") (:form . "III") (:end . 54) (:start . 51)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 58) (:start . 55)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 67)\n  (:start . 59) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 72) (:start . 68)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "Dr.") (:form . "Dr.") (:end . 76) (:start . 73)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "N.") (:form . "N.") (:end . 79) (:start . 77)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Perrimon") (:form . "Perrimon") (:end . 88)\n  (:start . 80) (:id . 54))\n ((:tag . "POS") (:stem . "'s") (:form . "'s") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "lab") (:form . "lab") (:end . 94) (:start . 91)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "dmef2-gal4") (:form . "Dmef2-Gal4") (:end . 114)\n  (:start . 104) (:id . 60))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Dr.") (:form . "Dr.") (:end . 136) (:start . 133)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "A.") (:form . "A.") (:end . 139) (:start . 137)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "Michelson") (:form . "Michelson") (:end . 149)\n  (:start . 140) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 150) (:start . 149)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.288) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102417@unknown@formal@none@1@S@Expression information of these Gal4 drivers is provided in Table 1.@(((:tag . "NN") (:stem . "expression") (:form . "Expression") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 22)\n  (:start . 11) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 44))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 31) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "gal4") (:form . "Gal4") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "driver") (:form . "drivers") (:end . 44)\n  (:start . 37) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 67) (:start . 66)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 68) (:start . 67)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.289) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102418@unknown@formal@none@1@S@A stock carrying the ubiquitous actin-Gal4 driver (P-actin-Gal4 UAS-GFP/CyO; lethal insertion on Chromosome II) was obtained from Dr. R. Sousa.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "stock") (:form . "stock") (:end . 7) (:start . 2)\n  (:id . 43))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "ubiquitous") (:form . "ubiquitous") (:end . 31)\n  (:start . 21) (:id . 46))\n ((:tag . "NN") (:stem . "actin-gal4") (:form . "actin-Gal4") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "driver") (:form . "driver") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "P-actin-Gal4") (:form . "P-actin-Gal4") (:end . 63)\n  (:start . 51) (:id . 50))\n ((:tag . "NNP") (:stem . "UAS-GFP/CyO") (:form . "UAS-GFP/CyO") (:end . 75)\n  (:start . 64) (:id . 51))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 76) (:start . 75)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "lethal") (:form . "lethal") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 93)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 96) (:start . 94)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 107)\n  (:start . 97) (:id . 56))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 110) (:start . 108)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 111) (:start . 110)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 124)\n  (:start . 116) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 129) (:start . 125)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Dr.") (:form . "Dr.") (:end . 133) (:start . 130)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "R.") (:form . "R.") (:end . 136) (:start . 134)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Sousa") (:form . "Sousa") (:end . 142)\n  (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.290) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102420@unknown@formal@none@1@S@Transgenic flies SgsGFP-1 (insertion on Chromosome X) and SgsGFP-2 (insertion on Chromosome II) containing the chimeric gene construct Sgs?3-GFP were obtained from Dr. A. J. Andres.@(((:tag . "JJ") (:stem . "transgenic") (:form . "Transgenic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "sgsgfp-1") (:form . "SgsGFP-1") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 50)\n  (:start . 40) (:id . 48))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 52) (:start . 51)\n  (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 53) (:start . 52)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "sgsgfp-2") (:form . "SgsGFP-2") (:end . 66)\n  (:start . 58) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "insertion") (:form . "insertion") (:end . 77)\n  (:start . 68) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Chromosome") (:form . "Chromosome") (:end . 91)\n  (:start . 81) (:id . 56))\n ((:tag . "CD") (:stem . "ii") (:form . "II") (:end . 94) (:start . 92)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 106)\n  (:start . 96) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "chimeric") (:form . "chimeric") (:end . 119)\n  (:start . 111) (:id . 61))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 134)\n  (:start . 125) (:id . 63))\n ((:tag . "NNP") (:stem . "Sgs?3-GFP") (:form . "Sgs?3-GFP") (:end . 144)\n  (:start . 135) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 149) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 158)\n  (:start . 150) (:id . 66))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "Dr.") (:form . "Dr.") (:end . 167) (:start . 164)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "A.") (:form . "A.") (:end . 170) (:start . 168)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "J.") (:form . "J.") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Andres") (:form . "Andres") (:end . 180)\n  (:start . 174) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s7.292) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102421@unknown@formal@none@1@S@For expression of ADGF-A using the HS-ADGF-A construct, flies were heat shocked as late embryos/early first instars at 37 °C for 30 min.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 54)\n  (:start . 45) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 61) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "NN") (:stem . "heat") (:form . "heat") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBD") (:stem . "shock") (:form . "shocked") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "embryos/early") (:form . "embryos/early")\n  (:end . 101) (:start . 88) (:id . 57))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 107)\n  (:start . 102) (:id . 58))\n ((:tag . "NNS") (:stem . "instar") (:form . "instars") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 121) (:start . 119)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 131) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 135) (:start . 132)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s7.293) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102422@unknown@formal@none@1@S@In all rescue experiments, 30 freshly hatched homozygous first-instar larvae were selected using a GFP dissecting microscope and transferred into fresh vials (at least four vials for each variant).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "rescue") (:form . "rescue") (:end . 13) (:start . 7)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 25)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "freshly") (:form . "freshly") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "hatch") (:form . "hatched") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "homozygous") (:form . "homozygous") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "first-instar") (:form . "first-instar") (:end . 69)\n  (:start . 57) (:id . 51))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "select") (:form . "selected") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "GFP") (:form . "GFP") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "dissect") (:form . "dissecting") (:end . 113)\n  (:start . 103) (:id . 58))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 124)\n  (:start . 114) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "transfer") (:form . "transferred") (:end . 140)\n  (:start . 129) (:id . 61))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 145) (:start . 141)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "fresh") (:form . "fresh") (:end . 151)\n  (:start . 146) (:id . 63))\n ((:tag . "NNS") (:stem . "vial") (:form . "vials") (:end . 157)\n  (:start . 152) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 159) (:start . 158)\n  (:id . 65))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 161) (:start . 159)\n  (:id . 66))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 167)\n  (:start . 162) (:id . 67))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 172) (:start . 168)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "vial") (:form . "vials") (:end . 178)\n  (:start . 173) (:id . 69))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 182) (:start . 179)\n  (:id . 70))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 187) (:start . 183)\n  (:id . 71))\n ((:tag . "NN") (:stem . "variant") (:form . "variant") (:end . 195)\n  (:start . 188) (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 196) (:start . 195)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s7.294) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102423@unknown@formal@none@1@S@They were left to develop at 25 °C and examined as wandering third-instar larvae, pupae, and adults.@(((:tag . "PRP") (:stem . "they") (:form . "They") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "leave") (:form . "left") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "VB") (:stem . "develop") (:form . "develop") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 28) (:start . 26)\n  (:id . 47))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 47)\n  (:start . 39) (:id . 51))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 50) (:start . 48)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "wander") (:form . "wandering") (:end . 60)\n  (:start . 51) (:id . 53))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 73)\n  (:start . 61) (:id . 54))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 80)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "pupa") (:form . "pupae") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "adult") (:form . "adults") (:end . 99)\n  (:start . 93) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.295) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102424@unknown@formal@none@1@S@Ecdysone treatment@(((:tag . "NNP") (:stem . "Ecdysone") (:form . "Ecdysone") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "treatment") (:form . "treatment") (:end . 18)\n  (:start . 9) (:id . 43)))@@@1@2@((:identifiers (:sid . :s7.296) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102425@unknown@formal@none@1@S@Mutant larvae were raised on plates with yeast paste at 25 °C and transferred to vials with glucose-yeast medium (control) or with glucose-yeast medium containing 20-hydroxyecdysone (H-5142; Sigma-Aldrich, St.@(((:tag . "JJ") (:stem . "mutant") (:form . "Mutant") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "plate") (:form . "plates") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "paste") (:form . "paste") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "transfer") (:form . "transferred") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 80) (:start . 78)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "vial") (:form . "vials") (:end . 86) (:start . 81)\n  (:id . 57))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "glucose-yeast") (:form . "glucose-yeast")\n  (:end . 105) (:start . 92) (:id . 59))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 112)\n  (:start . 106) (:id . 60))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 121)\n  (:start . 114) (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 122) (:start . 121)\n  (:id . 63))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 125) (:start . 123)\n  (:id . 64))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 130) (:start . 126)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "glucose-yeast") (:form . "glucose-yeast")\n  (:end . 144) (:start . 131) (:id . 66))\n ((:tag . "NN") (:stem . "medium") (:form . "medium") (:end . 151)\n  (:start . 145) (:id . 67))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 162)\n  (:start . 152) (:id . 68))\n ((:tag . "NN") (:stem . "20-hydroxyecdysone") (:form . "20-hydroxyecdysone")\n  (:end . 181) (:start . 163) (:id . 69))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 183) (:start . 182)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "H-5142") (:form . "H-5142") (:end . 189)\n  (:start . 183) (:id . 71))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 190) (:start . 189)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "sigma-aldrich") (:form . "Sigma-Aldrich")\n  (:end . 204) (:start . 191) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 205) (:start . 204)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "St") (:form . "St") (:end . 208) (:start . 206)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s7.297) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102426@unknown@formal@none@1@S@Louis, Missouri, United States) at a concentration of 0.5 mg/ml shortly after the L2/L3 molt.@(((:tag . "NNP") (:stem . "Louis") (:form . "Louis") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "Missouri") (:form . "Missouri") (:end . 15)\n  (:start . 7) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 23)\n  (:start . 17) (:id . 46))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 30)\n  (:start . 24) (:id . 47))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 36) (:start . 35)\n  (:id . 50))\n ((:tag . "NN") (:stem . "concentration") (:form . "concentration")\n  (:end . 50) (:start . 37) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "0.5") (:form . "0.5") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NN") (:stem . "mg/ml") (:form . "mg/ml") (:end . 63) (:start . 58)\n  (:id . 54))\n ((:tag . "RB") (:stem . "shortly") (:form . "shortly") (:end . 71)\n  (:start . 64) (:id . 55))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 57))\n ((:tag . "NN") (:stem . "l2/l3") (:form . "L2/L3") (:end . 87) (:start . 82)\n  (:id . 58))\n ((:tag . "NN") (:stem . "molt") (:form . "molt") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 93) (:start . 92)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s7.298) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102427@unknown@formal@none@1@S@Numbers of puparia were counted at 12-h intervals after the 120-h time point (when the first control larvae start to pupariate).@(((:tag . "NNPS") (:stem . "Number") (:form . "Numbers") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NN") (:stem . "puparia") (:form . "puparia") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "count") (:form . "counted") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 34) (:start . 32)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "12-h") (:form . "12-h") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "interval") (:form . "intervals") (:end . 49)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 55) (:start . 50)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "120-h") (:form . "120-h") (:end . 65) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 70) (:start . 66)\n  (:id . 53))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 76) (:start . 71)\n  (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 78) (:start . 77)\n  (:id . 55))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 92) (:start . 87)\n  (:id . 58))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 100)\n  (:start . 93) (:id . 59))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 107)\n  (:start . 101) (:id . 60))\n ((:tag . "VBP") (:stem . "start") (:form . "start") (:end . 113)\n  (:start . 108) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "VB") (:stem . "pupariate") (:form . "pupariate") (:end . 126)\n  (:start . 117) (:id . 63))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 127) (:start . 126)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.299) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102428@unknown@formal@none@1@S@The ecd1 flies (Bloomington stock BL-218) served as a control for the functional 20E diet [31]: flies were raised at 22 °C (permissive temperature for the temperature-sensitive ecd1 mutation) and transferred to vials with control or 20E-containing diet and raised at 29 °C (restrictive temperature).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ecd1") (:form . "ecd1") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 16) (:start . 15)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Bloomington") (:form . "Bloomington") (:end . 27)\n  (:start . 16) (:id . 46))\n ((:tag . "NN") (:stem . "stock") (:form . "stock") (:end . 33) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "bl-218") (:form . "BL-218") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "serve") (:form . "served") (:end . 48)\n  (:start . 42) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 51) (:start . 49)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 52))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 61)\n  (:start . 54) (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 80)\n  (:start . 70) (:id . 56))\n ((:tag . "NN") (:stem . "20e") (:form . "20E") (:end . 84) (:start . 81)\n  (:id . 57))\n ((:tag . "NN") (:stem . "diet") (:form . "diet") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . 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"permissive") (:end . 134)\n  (:start . 124) (:id . 70))\n ((:tag . "NN") (:stem . "temperature") (:form . "temperature") (:end . 146)\n  (:start . 135) (:id . 71))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 150) (:start . 147)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "temperature-sensitive")\n  (:form . "temperature-sensitive") (:end . 176) (:start . 155) (:id . 74))\n ((:tag . "NN") (:stem . "ecd1") (:form . "ecd1") (:end . 181) (:start . 177)\n  (:id . 75))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 190)\n  (:start . 182) (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 191) (:start . 190)\n  (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 195) (:start . 192)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "transfer") (:form . "transferred") (:end . 207)\n  (:start . 196) (:id . 79))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 210) (:start . 208)\n  (:id . 80))\n ((:tag . "NNS") (:stem . "vial") (:form . "vials") (:end . 216)\n  (:start . 211) (:id . 81))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 221) (:start . 217)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "control") (:form . "control") (:end . 229)\n  (:start . 222) (:id . 83))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 232) (:start . 230)\n  (:id . 84))\n ((:tag . "JJ") (:stem . "20e-containing") (:form . "20E-containing")\n  (:end . 247) (:start . 233) (:id . 85))\n ((:tag . "NN") (:stem . "diet") (:form . "diet") (:end . 252) (:start . 248)\n  (:id . 86))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 256) (:start . 253)\n  (:id . 87))\n ((:tag . "VBN") (:stem . "raise") (:form . "raised") (:end . 263)\n  (:start . 257) (:id . 88))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 266) (:start . 264)\n  (:id . 89))\n ((:tag . "CD") (:stem . "29") (:form . "29") (:end . 269) (:start . 267)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 272) (:start . 270)\n  (:id . 91))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 274) (:start . 273)\n  (:id . 92))\n ((:tag . "JJ") (:stem . "restrictive") (:form . "restrictive") (:end . 285)\n  (:start . 274) (:id . 93))\n ((:tag . "NN") (:stem . "temperature") (:form . "temperature") (:end . 297)\n  (:start . 286) (:id . 94))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 298) (:start . 297)\n  (:id . 95))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 299) (:start . 298)\n  (:id . 96)))@@@1@55@((:identifiers (:sid . :s7.300) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102430@unknown@formal@none@1@S@Living late third-instar larvae were washed and examined in PBS using a standard dissecting microscope with transmitted light.@(((:tag . "VBG") (:stem . "live") (:form . "Living") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 24)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "wash") (:form . "washed") (:end . 43) (:start . 37)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "examine") (:form . "examined") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 63) (:start . 60)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 80)\n  (:start . 72) (:id . 54))\n ((:tag . "VBG") (:stem . "dissect") (:form . "dissecting") (:end . 91)\n  (:start . 81) (:id . 55))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 102)\n  (:start . 92) (:id . 56))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "transmit") (:form . "transmitted") (:end . 119)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "light") (:form . "light") (:end . 125)\n  (:start . 120) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 126) (:start . 125)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s7.302) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102431@unknown@formal@none@1@S@For finer analysis, the fat body was dissected from larvae in PBS and observed using a dissecting microscope.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "finer") (:form . "finer") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 19) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 23) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "fat") (:form . "fat") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "dissect") (:form . "dissected") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 51) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 58)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 69) (:start . 66)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 78)\n  (:start . 70) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 86) (:start . 85)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "dissect") (:form . "dissecting") (:end . 97)\n  (:start . 87) (:id . 59))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 108)\n  (:start . 98) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.303) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102432@unknown@formal@none@1@S@GFP-stained fat body was observed in living, etherized larvae in PBS solution on a standard microscopic slide with a coverslip under a fluorescence microscope.@(((:tag . "JJ") (:stem . "gfp-stained") (:form . "GFP-stained") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "fat") (:form . "fat") (:end . 15) (:start . 12)\n  (:id . 43))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 33)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "NN") (:stem . "living") (:form . "living") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "etherize") (:form . "etherized") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 61)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 77)\n  (:start . 69) (:id . 54))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 80) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 82) (:start . 81)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 91)\n  (:start . 83) (:id . 57))\n ((:tag . "JJ") (:stem . "microscopic") (:form . "microscopic") (:end . 103)\n  (:start . 92) (:id . 58))\n ((:tag . "NN") (:stem . "slide") (:form . "slide") (:end . 109)\n  (:start . 104) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 114) (:start . 110)\n  (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "NN") (:stem . "coverslip") (:form . "coverslip") (:end . 126)\n  (:start . 117) (:id . 62))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 132)\n  (:start . 127) (:id . 63))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 147)\n  (:start . 135) (:id . 65))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 158)\n  (:start . 148) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s7.304) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102433@unknown@formal@none@1@S@Hemocyte counts and observations@(((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocyte") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "count") (:form . "counts") (:end . 15) (:start . 9)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 32)\n  (:start . 20) (:id . 45)))@@@1@4@((:identifiers (:sid . :s7.305) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102434@unknown@formal@none@1@S@Circulating hemocytes were obtained by opening two late third-instar larvae in 30 ?l of PBS.@(((:tag . "VBG") (:stem . "circulate") (:form . "Circulating") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "open") (:form . "opening") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "late") (:form . "late") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "third-instar") (:form . "third-instar") (:end . 68)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 75)\n  (:start . 69) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 78) (:start . 76)\n  (:id . 52))\n ((:tag . "CD") (:stem . "30") (:form . "30") (:end . 81) (:start . 79)\n  (:id . 53))\n ((:tag . "NN") (:stem . "?l") (:form . "?l") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s7.306) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102435@unknown@formal@none@1@S@This allowed us to collect all hemolymph from the larvae in a defined volume.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "allow") (:form . "allowed") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "collect") (:form . "collect") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 40)\n  (:start . 31) (:id . 48))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 45) (:start . 41)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 56)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 69)\n  (:start . 62) (:id . 54))\n ((:tag . "NN") (:stem . "volume") (:form . "volume") (:end . 76)\n  (:start . 70) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 77) (:start . 76)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s7.307) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102436@unknown@formal@none@1@S@The solution with circulating hemocytes was mixed by gently pipetting, and part was transferred into the chamber of an improved Neubauer hemocytometer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VBG") (:stem . "circulate") (:form . "circulating") (:end . 29)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 39)\n  (:start . 30) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 43) (:start . 40)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "mix") (:form . "mixed") (:end . 49) (:start . 44)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 52) (:start . 50)\n  (:id . 49))\n ((:tag . "RB") (:stem . "gently") (:form . "gently") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "VBG") (:stem . "pipette") (:form . "pipetting") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 79) (:start . 75)\n  (:id . 54))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 83) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "transfer") (:form . "transferred") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 100) (:start . 96)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 58))\n ((:tag . "NN") (:stem . "chamber") (:form . "chamber") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 115) (:start . 113)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 118) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "improve") (:form . "improved") (:end . 127)\n  (:start . 119) (:id . 62))\n ((:tag . "NNP") (:stem . "Neubauer") (:form . "Neubauer") (:end . 136)\n  (:start . 128) (:id . 63))\n ((:tag . "NN") (:stem . "hemocytometer") (:form . "hemocytometer")\n  (:end . 150) (:start . 137) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 151) (:start . 150)\n  (:id . 65)))@@@1@24@((:identifiers (:sid . :s7.308) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102437@unknown@formal@none@1@S@Cell number was recounted to one animal equivalent.@(((:tag . "NN") (:stem . "cell") (:form . "Cell") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "recount") (:form . "recounted") (:end . 25)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "animal") (:form . "animal") (:end . 39)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "equivalent") (:form . "equivalent") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 51) (:start . 50)\n  (:id . 50)))@@@1@9@((:identifiers (:sid . :s7.309) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102438@unknown@formal@none@1@S@Hemocyte morphology was observed by differential interference contrast microscopy of living cells in Shields and Sang Insect Medium (Sigma-Aldrich) obtained by the same procedure as for counting.@(((:tag . "NNP") (:stem . "Hemocyte") (:form . "Hemocyte") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "morphology") (:form . "morphology") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 32)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "differential") (:form . "differential") (:end . 48)\n  (:start . 36) (:id . 47))\n ((:tag . "NN") (:stem . "interference") (:form . "interference") (:end . 61)\n  (:start . 49) (:id . 48))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 70)\n  (:start . 62) (:id . 49))\n ((:tag . "NN") (:stem . "microscopy") (:form . "microscopy") (:end . 81)\n  (:start . 71) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "live") (:form . "living") (:end . 91) (:start . 85)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 97) (:start . 92)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Shields") (:form . "Shields") (:end . 108)\n  (:start . 101) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Sang") (:form . "Sang") (:end . 117) (:start . 113)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Insect") (:form . "Insect") (:end . 124)\n  (:start . 118) (:id . 58))\n ((:tag . "NNP") (:stem . "Medium") (:form . "Medium") (:end . 131)\n  (:start . 125) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 133) (:start . 132)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sigma-aldrich") (:form . "Sigma-Aldrich")\n  (:end . 146) (:start . 133) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 147) (:start . 146)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 156)\n  (:start . 148) (:id . 63))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 159) (:start . 157)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 163) (:start . 160)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 168) (:start . 164)\n  (:id . 66))\n ((:tag . "NN") (:stem . "procedure") (:form . "procedure") (:end . 178)\n  (:start . 169) (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 181) (:start . 179)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 185) (:start . 182)\n  (:id . 69))\n ((:tag . "NN") (:stem . "counting") (:form . "counting") (:end . 194)\n  (:start . 186) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s7.310) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102440@unknown@formal@none@1@S@Crystal cells were visualized by heating larvae at 60 °C for 10 min in a water bath [46].@(((:tag . "JJ") (:stem . "crystal") (:form . "Crystal") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "visualize") (:form . "visualized") (:end . 29)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 32) (:start . 30)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "heat") (:form . "heating") (:end . 40)\n  (:start . 33) (:id . 47))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 47)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 50) (:start . 48)\n  (:id . 49))\n ((:tag . "CD") (:stem . "60") (:form . "60") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "°C") (:form . "°C") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "NN") (:stem . "min") (:form . "min") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 70) (:start . 68)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 72) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "water") (:form . "water") (:end . 78) (:start . 73)\n  (:id . 57))\n ((:tag . "NN") (:stem . "bath") (:form . "bath") (:end . 83) (:start . 79)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 85) (:start . 84)\n  (:id . 59))\n ((:tag . "CD") (:stem . "46") (:form . "46") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 88) (:start . 87)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 89) (:start . 88)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s7.312) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102441@unknown@formal@none@1@S@GFP-stained hemocytes were observed in living, etherized larvae in PBS solution on a standard microscopic slide with a coverslip under the fluorescence microscope or by deposition of hemocytes in PBS as for counting and observing under the fluorescence microscope.@(((:tag . "JJ") (:stem . "gfp-stained") (:form . "GFP-stained") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 21)\n  (:start . 12) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 26) (:start . 22)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 35)\n  (:start . 27) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "NN") (:stem . "living") (:form . "living") (:end . 45)\n  (:start . 39) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 46) (:start . 45)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "etherize") (:form . "etherized") (:end . 56)\n  (:start . 47) (:id . 49))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 63)\n  (:start . 57) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 66) (:start . 64)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 70) (:start . 67)\n  (:id . 52))\n ((:tag . "NN") (:stem . "solution") (:form . "solution") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 84) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "standard") (:form . "standard") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "JJ") (:stem . "microscopic") (:form . "microscopic") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "NN") (:stem . "slide") (:form . "slide") (:end . 111)\n  (:start . 106) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 116) (:start . 112)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 118) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "coverslip") (:form . "coverslip") (:end . 128)\n  (:start . 119) (:id . 61))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 63))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 151)\n  (:start . 139) (:id . 64))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 162)\n  (:start . 152) (:id . 65))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 165) (:start . 163)\n  (:id . 66))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 168) (:start . 166)\n  (:id . 67))\n ((:tag . "NN") (:stem . "deposition") (:form . "deposition") (:end . 179)\n  (:start . 169) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 182) (:start . 180)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 192)\n  (:start . 183) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 195) (:start . 193)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "PBS") (:form . "PBS") (:end . 199) (:start . 196)\n  (:id . 72))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 202) (:start . 200)\n  (:id . 73))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 206) (:start . 203)\n  (:id . 74))\n ((:tag . "VBG") (:stem . "count") (:form . "counting") (:end . 215)\n  (:start . 207) (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 219) (:start . 216)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "observe") (:form . "observing") (:end . 229)\n  (:start . 220) (:id . 77))\n ((:tag . "IN") (:stem . "under") (:form . "under") (:end . 235)\n  (:start . 230) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 239) (:start . 236)\n  (:id . 79))\n ((:tag . "NN") (:stem . "fluorescence") (:form . "fluorescence") (:end . 252)\n  (:start . 240) (:id . 80))\n ((:tag . "NN") (:stem . "microscope") (:form . "microscope") (:end . 263)\n  (:start . 253) (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s7.313) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102442@unknown@formal@none@1@S@Transgenic constructs@(((:tag . "JJ") (:stem . "transgenic") (:form . "Transgenic") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 21)\n  (:start . 11) (:id . 43)))@@@1@2@((:identifiers (:sid . :s7.314) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102443@unknown@formal@none@1@S@Wild-type cDNA for ADGF-A was amplified by PCR using proofreading DNA polymerase (ProofStart; Invitrogen, Carlsbad, California, United States) from a pOT2 vector containing the ADGF-A EST-clone (GH08276) using the following primers: 5?- CGTCTAGAATGTCGCCAGTCATCCGCC-3? (5? end primer with XbaI tail) and 5?- GCTGATCATCAATCGATCCGTTGACTGGGGGA-3? (3? end primer with BclI tail).@(((:tag . "JJ") (:stem . "wild-type") (:form . "Wild-type") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 14) (:start . 10)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 39)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "proofread") (:form . "proofreading") (:end . 65)\n  (:start . 53) (:id . 51))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "polymerase") (:form . "polymerase") (:end . 80)\n  (:start . 70) (:id . 53))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 82) (:start . 81)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ProofStart") (:form . "ProofStart") (:end . 92)\n  (:start . 82) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 93) (:start . 92)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Invitrogen") (:form . "Invitrogen") (:end . 104)\n  (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Carlsbad") (:form . "Carlsbad") (:end . 114)\n  (:start . 106) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 115) (:start . 114)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "California") (:form . "California") (:end . 126)\n  (:start . 116) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 134)\n  (:start . 128) (:id . 63))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 141)\n  (:start . 135) (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 142) (:start . 141)\n  (:id . 65))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "pot2") (:form . "pOT2") (:end . 154) (:start . 150)\n  (:id . 68))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 161)\n  (:start . 155) (:id . 69))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 172)\n  (:start . 162) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 176) (:start . 173)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 183)\n  (:start . 177) (:id . 72))\n ((:tag . "NNP") (:stem . "EST-clone") (:form . "EST-clone") (:end . 193)\n  (:start . 184) (:id . 73))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 195) (:start . 194)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "GH08276") (:form . "GH08276") (:end . 202)\n  (:start . 195) (:id . 75))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 203) (:start . 202)\n  (:id . 76))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 209) (:start . 204)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 213) (:start . 210)\n  (:id . 78))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 223)\n  (:start . 214) (:id . 79))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 231)\n  (:start . 224) (:id . 80))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 232) (:start . 231)\n  (:id . 81))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 236) (:start . 233)\n  (:id . 82))\n ((:tag . "NN") (:stem . "cgtctagaatgtcgccagtcatccgcc-3")\n  (:form . "CGTCTAGAATGTCGCCAGTCATCCGCC-3") (:end . 266) (:start . 237)\n  (:id . 83))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 267) (:start . 266)\n  (:id . 84))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 269) (:start . 268)\n  (:id . 85))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 270) (:start . 269)\n  (:id . 86))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 271) (:start . 270)\n  (:id . 87))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 275) (:start . 272)\n  (:id . 88))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 282)\n  (:start . 276) (:id . 89))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 287) (:start . 283)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "XbaI") (:form . "XbaI") (:end . 292) (:start . 288)\n  (:id . 91))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 297) (:start . 293)\n  (:id . 92))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 298) (:start . 297)\n  (:id . 93))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 302) (:start . 299)\n  (:id . 94))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 306) (:start . 303)\n  (:id . 95))\n ((:tag . "NN") (:stem . "gctgatcatcaatcgatccgttgactggggga-3")\n  (:form . "GCTGATCATCAATCGATCCGTTGACTGGGGGA-3") (:end . 341) (:start . 307)\n  (:id . 96))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 342) (:start . 341)\n  (:id . 97))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 344) (:start . 343)\n  (:id . 98))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 345) (:start . 344)\n  (:id . 99))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 346) (:start . 345)\n  (:id . 100))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 350) (:start . 347)\n  (:id . 101))\n ((:tag . "NN") (:stem . "primer") (:form . "primer") (:end . 357)\n  (:start . 351) (:id . 102))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 362) (:start . 358)\n  (:id . 103))\n ((:tag . "NNP") (:stem . "BclI") (:form . "BclI") (:end . 367) (:start . 363)\n  (:id . 104))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 372) (:start . 368)\n  (:id . 105))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 373) (:start . 372)\n  (:id . 106))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 374) (:start . 373)\n  (:id . 107)))@@@1@66@((:identifiers (:sid . :s7.315) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102444@unknown@formal@none@1@S@The PCR product was cloned into the pGEM-T Easy vector (Promega, Madison, Wisconsin, United States), and the resulting plasmid (ADGF-A-pGEM) was cut by NotI/SpeI restriction enzymes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "PCR") (:form . "PCR") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 15)\n  (:start . 8) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pgem-t") (:form . "pGEM-T") (:end . 42)\n  (:start . 36) (:id . 49))\n ((:tag . "NN") (:stem . "easy") (:form . "Easy") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 56) (:start . 55)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Promega") (:form . "Promega") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Madison") (:form . "Madison") (:end . 72)\n  (:start . 65) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Wisconsin") (:form . "Wisconsin") (:end . 83)\n  (:start . 74) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "United") (:form . "United") (:end . 91)\n  (:start . 85) (:id . 59))\n ((:tag . "NNPS") (:stem . "States") (:form . "States") (:end . 98)\n  (:start . 92) (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 104) (:start . 101)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 118)\n  (:start . 109) (:id . 65))\n ((:tag . "NN") (:stem . "plasmid") (:form . "plasmid") (:end . 126)\n  (:start . 119) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 128) (:start . 127)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "ADGF-A-pGEM") (:form . "ADGF-A-pGEM") (:end . 139)\n  (:start . 128) (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 144) (:start . 141)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "cut") (:form . "cut") (:end . 148) (:start . 145)\n  (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 151) (:start . 149)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "NotI/SpeI") (:form . "NotI/SpeI") (:end . 161)\n  (:start . 152) (:id . 73))\n ((:tag . "NN") (:stem . "restriction") (:form . "restriction") (:end . 173)\n  (:start . 162) (:id . 74))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 181)\n  (:start . 174) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s7.316) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102445@unknown@formal@none@1@S@The ADGF-A fragment was then cloned into the pCaSpeR-hs) vector cut by NotI/XbaI to obtain the HS-ADGF-A construct.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 10)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 19)\n  (:start . 11) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 35)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pcasper-hs") (:form . "pCaSpeR-hs") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 63)\n  (:start . 57) (:id . 52))\n ((:tag . "VBN") (:stem . "cut") (:form . "cut") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "NotI/XbaI") (:form . "NotI/XbaI") (:end . 80)\n  (:start . 71) (:id . 55))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 83) (:start . 81)\n  (:id . 56))\n ((:tag . "VB") (:stem . "obtain") (:form . "obtain") (:end . 90)\n  (:start . 84) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "HS-ADGF-A") (:form . "HS-ADGF-A") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 114)\n  (:start . 105) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s7.317) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102446@unknown@formal@none@1@S@The myc tag was added to the C terminus of the ADGF-A protein for detection by anti-c-Myc antibody (Sigma-Aldrich).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "myc") (:form . "myc") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "tag") (:form . "tag") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "add") (:form . "added") (:end . 21) (:start . 16)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 24) (:start . 22)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C") (:form . "C") (:end . 30) (:start . 29)\n  (:id . 49))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 39)\n  (:start . 31) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 53)\n  (:start . 47) (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 61)\n  (:start . 54) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 75)\n  (:start . 66) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "anti-c-myc") (:form . "anti-c-Myc") (:end . 89)\n  (:start . 79) (:id . 58))\n ((:tag . "NN") (:stem . "antibody") (:form . "antibody") (:end . 98)\n  (:start . 90) (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 100) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sigma-aldrich") (:form . "Sigma-Aldrich")\n  (:end . 113) (:start . 100) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 114) (:start . 113)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s7.318) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102447@unknown@formal@none@1@S@To produce a UAS-ADGF-Amyc construct, the ADGF-A fragment was amplified (by ProofStart from pOT2 vector) using the following primers: 5?- AATCTCGAGCTCATCATGTCGCCAGTCATC-3? (5? end with XhoI tail) and 5?- TATCTAGATCGATCCGTTGACTGGGGG-3? (3? end with XbaI tail).@(((:tag . "TO") (:stem . "to") (:form . "To") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VB") (:stem . "produce") (:form . "produce") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NN") (:stem . "uas-adgf-amyc") (:form . "UAS-ADGF-Amyc")\n  (:end . 26) (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "construct") (:form . "construct") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 61) (:start . 58)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "amplify") (:form . "amplified") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "ProofStart") (:form . "ProofStart") (:end . 86)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 91) (:start . 87)\n  (:id . 56))\n ((:tag . "NN") (:stem . "pot2") (:form . "pOT2") (:end . 96) (:start . 92)\n  (:id . 57))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 103)\n  (:start . 97) (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 110) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 124)\n  (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 132)\n  (:start . 125) (:id . 63))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 133) (:start . 132)\n  (:id . 64))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NN") (:stem . "aatctcgagctcatcatgtcgccagtcatc-3")\n  (:form . "AATCTCGAGCTCATCATGTCGCCAGTCATC-3") (:end . 170) (:start . 138)\n  (:id . 66))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 171) (:start . 170)\n  (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 173) (:start . 172)\n  (:id . 68))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 174) (:start . 173)\n  (:id . 69))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 175) (:start . 174)\n  (:id . 70))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 179) (:start . 176)\n  (:id . 71))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "XhoI") (:form . "XhoI") (:end . 189) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 194) (:start . 190)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 195) (:start . 194)\n  (:id . 75))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 199) (:start . 196)\n  (:id . 76))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 203) (:start . 200)\n  (:id . 77))\n ((:tag . "NN") (:stem . "tatctagatcgatccgttgactggggg-3")\n  (:form . "TATCTAGATCGATCCGTTGACTGGGGG-3") (:end . 233) (:start . 204)\n  (:id . 78))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 234) (:start . 233)\n  (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 236) (:start . 235)\n  (:id . 80))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 237) (:start . 236)\n  (:id . 81))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 238) (:start . 237)\n  (:id . 82))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 242) (:start . 239)\n  (:id . 83))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 247) (:start . 243)\n  (:id . 84))\n ((:tag . "NNP") (:stem . "XbaI") (:form . "XbaI") (:end . 252) (:start . 248)\n  (:id . 85))\n ((:tag . "NN") (:stem . "tail") (:form . "tail") (:end . 257) (:start . 253)\n  (:id . 86))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 258) (:start . 257)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 259) (:start . 258)\n  (:id . 88)))@@@1@47@((:identifiers (:sid . :s7.319) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102448@unknown@formal@none@1@S@The fragment was cut by XhoI/XbaI and cloned into the pUAST vector modified by MZ.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fragment") (:form . "fragment") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "cut") (:form . "cut") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "XhoI/XbaI") (:form . "XhoI/XbaI") (:end . 33)\n  (:start . 24) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "clone") (:form . "cloned") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 49) (:start . 45)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "puast") (:form . "pUAST") (:end . 59) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "vector") (:form . "vector") (:end . 66)\n  (:start . 60) (:id . 53))\n ((:tag . "VBN") (:stem . "modify") (:form . "modified") (:end . 75)\n  (:start . 67) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 78) (:start . 76)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MZ") (:form . "MZ") (:end . 81) (:start . 79)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 82) (:start . 81)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s7.320) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102450@unknown@formal@none@1@S@A mutated version—UAS-mutADGF-Amyc—was prepared in the same way as UAS-ADGF-Amyc, but pBLUESCRIPT containing mutated ADGF-A cDNA was used as a template.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 9)\n  (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "JJ") (:stem . "—") (:form . "—") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "UAS-mutADGF-Amyc") (:form . "UAS-mutADGF-Amyc")\n  (:end . 34) (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "—") (:form . "—") (:end . 35) (:start . 34)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "was") (:form . "was") (:end . 38) (:start . 35)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 47)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "NN") (:stem . "way") (:form . "way") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "UAS-ADGF-Amyc") (:form . "UAS-ADGF-Amyc")\n  (:end . 80) (:start . 67) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "pbluescript") (:form . "pBLUESCRIPT") (:end . 97)\n  (:start . 86) (:id . 58))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 108)\n  (:start . 98) (:id . 59))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 116)\n  (:start . 109) (:id . 60))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 123)\n  (:start . 117) (:id . 61))\n ((:tag . "NNP") (:stem . "cDNA") (:form . "cDNA") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 137) (:start . 133)\n  (:id . 64))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 140) (:start . 138)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 142) (:start . 141)\n  (:id . 66))\n ((:tag . "NN") (:stem . "template") (:form . "template") (:end . 151)\n  (:start . 143) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 152) (:start . 151)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s7.322) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102451@unknown@formal@none@1@S@The mutated version of ADGF-A (carrying a mutation causing the substitution of two amino acids—His386 and Ala387 for Glu and Leu, respectively) in the catalytic domain, shown to abolish adenosine deaminase activity [16], was prepared by recombinant PCR using the following recombinant primers: 5?- TCTACTTCGAGCTCGGAGAAACAAACTGGTTCGGT-3? and 5?- CTCCGAGCTCGAAGTAGAAATCAATGTCATCG-3? and the same 5? and 3? end primers as above.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "mutate") (:form . "mutated") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "version") (:form . "version") (:end . 19)\n  (:start . 12) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "ADGF-A") (:form . "ADGF-A") (:end . 29)\n  (:start . 23) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 39)\n  (:start . 31) (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 50)\n  (:start . 42) (:id . 50))\n ((:tag . "VBG") (:stem . "cause") (:form . "causing") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "substitution") (:form . "substitution") (:end . 75)\n  (:start . 63) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 54))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "NN") (:stem . "amino") (:form . "amino") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "acids") (:form . "acids") (:end . 94) (:start . 89)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "—") (:form . "—") (:end . 95) (:start . 94)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "His386") (:form . "His386") (:end . 101)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 105) (:start . 102)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Ala387") (:form . "Ala387") (:end . 112)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 116) (:start . 113)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Glu") (:form . "Glu") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Leu") (:form . "Leu") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "RB") (:stem . "respectively") (:form . "respectively") (:end . 142)\n  (:start . 130) (:id . 67))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 143) (:start . 142)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "catalytic") (:form . "catalytic") (:end . 160)\n  (:start . 151) (:id . 71))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 167)\n  (:start . 161) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 174)\n  (:start . 169) (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 75))\n ((:tag . "VB") (:stem . "abolish") (:form . "abolish") (:end . 185)\n  (:start . 178) (:id . 76))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 195)\n  (:start . 186) (:id . 77))\n ((:tag . "NN") (:stem . "deaminase") (:form . "deaminase") (:end . 205)\n  (:start . 196) (:id . 78))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 214)\n  (:start . 206) (:id . 79))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 216) (:start . 215)\n  (:id . 80))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 218) (:start . 216)\n  (:id . 81))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 219) (:start . 218)\n  (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 220) (:start . 219)\n  (:id . 83))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 224) (:start . 221)\n  (:id . 84))\n ((:tag . "VBN") (:stem . "prepare") (:form . "prepared") (:end . 233)\n  (:start . 225) (:id . 85))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 236) (:start . 234)\n  (:id . 86))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 248)\n  (:start . 237) (:id . 87))\n ((:tag . "NN") (:stem . "pcr") (:form . "PCR") (:end . 252) (:start . 249)\n  (:id . 88))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 258) (:start . 253)\n  (:id . 89))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 262) (:start . 259)\n  (:id . 90))\n ((:tag . "VBG") (:stem . "follow") (:form . "following") (:end . 272)\n  (:start . 263) (:id . 91))\n ((:tag . "JJ") (:stem . "recombinant") (:form . "recombinant") (:end . 284)\n  (:start . 273) (:id . 92))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 292)\n  (:start . 285) (:id . 93))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 293) (:start . 292)\n  (:id . 94))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 297) (:start . 294)\n  (:id . 95))\n ((:tag . "NN") (:stem . "tctacttcgagctcggagaaacaaactggttcggt-3")\n  (:form . "TCTACTTCGAGCTCGGAGAAACAAACTGGTTCGGT-3") (:end . 335)\n  (:start . 298) (:id . 96))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 336) (:start . 335)\n  (:id . 97))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 340) (:start . 337)\n  (:id . 98))\n ((:tag . "CD") (:stem . "5?-") (:form . "5?-") (:end . 344) (:start . 341)\n  (:id . 99))\n ((:tag . "NN") (:stem . "ctccgagctcgaagtagaaatcaatgtcatcg-3")\n  (:form . "CTCCGAGCTCGAAGTAGAAATCAATGTCATCG-3") (:end . 379) (:start . 345)\n  (:id . 100))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 380) (:start . 379)\n  (:id . 101))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 384) (:start . 381)\n  (:id . 102))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 388) (:start . 385)\n  (:id . 103))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 393) (:start . 389)\n  (:id . 104))\n ((:tag . "CD") (:stem . "5") (:form . "5") (:end . 395) (:start . 394)\n  (:id . 105))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 396) (:start . 395)\n  (:id . 106))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 400) (:start . 397)\n  (:id . 107))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 402) (:start . 401)\n  (:id . 108))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 403) (:start . 402)\n  (:id . 109))\n ((:tag . "NN") (:stem . "end") (:form . "end") (:end . 407) (:start . 404)\n  (:id . 110))\n ((:tag . "NNS") (:stem . "primer") (:form . "primers") (:end . 415)\n  (:start . 408) (:id . 111))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 418) (:start . 416)\n  (:id . 112))\n ((:tag . "RB") (:stem . "above") (:form . "above") (:end . 424)\n  (:start . 419) (:id . 113))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 425) (:start . 424)\n  (:id . 114)))@@@1@73@((:identifiers (:sid . :s7.323) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102452@unknown@formal@none@1@S@Adenosine and deoxyadenosine concentrations measurement@(((:tag . "NNP") (:stem . "Adenosine") (:form . "Adenosine") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NN") (:stem . "deoxyadenosine") (:form . "deoxyadenosine")\n  (:end . 28) (:start . 14) (:id . 44))\n ((:tag . "NNS") (:stem . "concentration") (:form . "concentrations")\n  (:end . 43) (:start . 29) (:id . 45))\n ((:tag . "NN") (:stem . "measurement") (:form . "measurement") (:end . 55)\n  (:start . 44) (:id . 46)))@@@1@5@((:identifiers (:sid . :s7.324) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SubSectionTitle|)))@oe@9-2-2011
5102453@unknown@formal@none@1@S@The detection method used liquid chromatography and mass spectrometry (LC/MS method) of deproteinated hemolymph samples.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "detection") (:form . "detection") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "VBD") (:stem . "use") (:form . "used") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "liquid") (:form . "liquid") (:end . 32)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "chromatography") (:form . "chromatography")\n  (:end . 47) (:start . 33) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 56) (:start . 52)\n  (:id . 49))\n ((:tag . "NN") (:stem . "spectrometry") (:form . "spectrometry") (:end . 69)\n  (:start . 57) (:id . 50))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 71) (:start . 70)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "LC/MS") (:form . "LC/MS") (:end . 76) (:start . 71)\n  (:id . 52))\n ((:tag . "NN") (:stem . "method") (:form . "method") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 84) (:start . 83)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "deproteinate") (:form . "deproteinated")\n  (:end . 101) (:start . 88) (:id . 56))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 111)\n  (:start . 102) (:id . 57))\n ((:tag . "NNS") (:stem . "sample") (:form . "samples") (:end . 119)\n  (:start . 112) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s7.325) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102454@unknown@formal@none@1@S@Larval hemolymph was collected from several larvae and centrifuged to pellet the hemocytes.@(((:tag . "JJ") (:stem . "larval") (:form . "Larval") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "collect") (:form . "collected") (:end . 30)\n  (:start . 21) (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 35) (:start . 31)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 43)\n  (:start . 36) (:id . 47))\n ((:tag . "NNS") (:stem . "larva") (:form . "larvae") (:end . 50)\n  (:start . 44) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "centrifuge") (:form . "centrifuged") (:end . 66)\n  (:start . 55) (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 69) (:start . 67)\n  (:id . 51))\n ((:tag . "VB") (:stem . "pellet") (:form . "pellet") (:end . 76)\n  (:start . 70) (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "hemocyte") (:form . "hemocytes") (:end . 90)\n  (:start . 81) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 91) (:start . 90)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s7.326) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102455@unknown@formal@none@1@S@1 ?l of hemolymph was diluted in 99 ?l of buffer.@(((:tag . "LS") (:stem . "1") (:form . "1") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "?l") (:form . "?l") (:end . 4) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 44))\n ((:tag . "NN") (:stem . "hemolymph") (:form . "hemolymph") (:end . 17)\n  (:start . 8) (:id . 45))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "dilute") (:form . "diluted") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "99") (:form . "99") (:end . 35) (:start . 33)\n  (:id . 49))\n ((:tag . "NN") (:stem . "?l") (:form . "?l") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "buffer") (:form . "buffer") (:end . 48)\n  (:start . 42) (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 49) (:start . 48)\n  (:id . 53)))@@@1@12@((:identifiers (:sid . :s7.327) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102456@unknown@formal@none@1@S@The sample was introduced in CH3CN-0.05% TFA (50:50) either via a syringe pump at 3 ?l/min or via an RP-C18 150 mm × 1 mm Symmetry C8 column at 50 ?l/min employing an LCQ electrospray ion source operated at 4.2 kV.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sample") (:form . "sample") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "introduce") (:form . "introduced") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 28) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "CH3CN-0.05") (:form . "CH3CN-0.05") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 40) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "TFA") (:form . "TFA") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "50:50") (:form . "50:50") (:end . 51) (:start . 46)\n  (:id . 51))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "CC") (:stem . "either") (:form . "either") (:end . 59)\n  (:start . 53) (:id . 53))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 63) (:start . 60)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "syringe") (:form . "syringe") (:end . 73)\n  (:start . 66) (:id . 56))\n ((:tag . "NN") (:stem . "pump") (:form . "pump") (:end . 78) (:start . 74)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 81) (:start . 79)\n  (:id . 58))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 83) (:start . 82)\n  (:id . 59))\n ((:tag . "NN") (:stem . "?l/min") (:form . "?l/min") (:end . 90)\n  (:start . 84) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 93) (:start . 91)\n  (:id . 61))\n ((:tag . "IN") (:stem . "via") (:form . "via") (:end . 97) (:start . 94)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 100) (:start . 98)\n  (:id . 63))\n ((:tag . "NN") (:stem . "rp-c18") (:form . "RP-C18") (:end . 107)\n  (:start . 101) (:id . 64))\n ((:tag . "CD") (:stem . "150") (:form . "150") (:end . 111) (:start . 108)\n  (:id . 65))\n ((:tag . "NN") (:stem . "mm") (:form . "mm") (:end . 114) (:start . 112)\n  (:id . 66))\n ((:tag . "NN") (:stem . "×") (:form . "×") (:end . 116) (:start . 115)\n  (:id . 67))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 118) (:start . 117)\n  (:id . 68))\n ((:tag . "NN") (:stem . "mm") (:form . "mm") (:end . 121) (:start . 119)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "Symmetry") (:form . "Symmetry") (:end . 130)\n  (:start . 122) (:id . 70))\n ((:tag . "NN") (:stem . "c8") (:form . "C8") (:end . 133) (:start . 131)\n  (:id . 71))\n ((:tag . "NN") (:stem . "column") (:form . "column") (:end . 140)\n  (:start . 134) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 143) (:start . 141)\n  (:id . 73))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 146) (:start . 144)\n  (:id . 74))\n ((:tag . "NN") (:stem . "?l/min") (:form . "?l/min") (:end . 153)\n  (:start . 147) (:id . 75))\n ((:tag . "VBG") (:stem . "employ") (:form . "employing") (:end . 163)\n  (:start . 154) (:id . 76))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 166) (:start . 164)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "LCQ") (:form . "LCQ") (:end . 170) (:start . 167)\n  (:id . 78))\n ((:tag . "NN") (:stem . "electrospray") (:form . "electrospray") (:end . 183)\n  (:start . 171) (:id . 79))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 187) (:start . 184)\n  (:id . 80))\n ((:tag . "NN") (:stem . "source") (:form . "source") (:end . 194)\n  (:start . 188) (:id . 81))\n ((:tag . "VBD") (:stem . "operate") (:form . "operated") (:end . 203)\n  (:start . 195) (:id . 82))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 206) (:start . 204)\n  (:id . 83))\n ((:tag . "CD") (:stem . "4.2") (:form . "4.2") (:end . 210) (:start . 207)\n  (:id . 84))\n ((:tag . "NN") (:stem . "kv") (:form . "kV") (:end . 213) (:start . 211)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 214) (:start . 213)\n  (:id . 86)))@@@1@45@((:identifiers (:sid . :s7.328) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102457@unknown@formal@none@1@S@The peaks were then identified using the electrospray MSN mass spectra obtained by the collision-induced decomposition of the MH+ ion and its product ions in a series of MSN experiments that were performed with the ion trap mass spectrometer.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "peak") (:form . "peaks") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 36) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "electrospray") (:form . "electrospray") (:end . 53)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "msn") (:form . "MSN") (:end . 57) (:start . 54)\n  (:id . 50))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 62) (:start . 58)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "spectrum") (:form . "spectra") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . "VBN") (:stem . "obtain") (:form . "obtained") (:end . 79)\n  (:start . 71) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "collision-induced") (:form . "collision-induced")\n  (:end . 104) (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "decomposition") (:form . "decomposition")\n  (:end . 118) (:start . 105) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "mh+") (:form . "MH+") (:end . 129) (:start . 126)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 133) (:start . 130)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 62))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 141) (:start . 138)\n  (:id . 63))\n ((:tag . "NN") (:stem . "product") (:form . "product") (:end . 149)\n  (:start . 142) (:id . 64))\n ((:tag . "NNS") (:stem . "ion") (:form . "ions") (:end . 154) (:start . 150)\n  (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 159) (:start . 158)\n  (:id . 67))\n ((:tag . "NN") (:stem . "series") (:form . "series") (:end . 166)\n  (:start . 160) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 169) (:start . 167)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "MSN") (:form . "MSN") (:end . 173) (:start . 170)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 185)\n  (:start . 174) (:id . 71))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 190) (:start . 186)\n  (:id . 72))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 195) (:start . 191)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 205)\n  (:start . 196) (:id . 74))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 210) (:start . 206)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 214) (:start . 211)\n  (:id . 76))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 218) (:start . 215)\n  (:id . 77))\n ((:tag . "NN") (:stem . "trap") (:form . "trap") (:end . 223) (:start . 219)\n  (:id . 78))\n ((:tag . "NN") (:stem . "mass") (:form . "mass") (:end . 228) (:start . 224)\n  (:id . 79))\n ((:tag . "NN") (:stem . "spectrometer") (:form . "spectrometer") (:end . 241)\n  (:start . 229) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s7.329) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102458@unknown@formal@none@1@S@The sugar moiety was cleaved off the adenosine molecule and produced ion with a molecular weight of 136 (adenine), which was then detected by MS.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "sugar") (:form . "sugar") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "moiety") (:form . "moiety") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "cleave") (:form . "cleaved") (:end . 28)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "off") (:form . "off") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 48))\n ((:tag . "NN") (:stem . "adenosine") (:form . "adenosine") (:end . 46)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "molecule") (:form . "molecule") (:end . 55)\n  (:start . 47) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 59) (:start . 56)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "produce") (:form . "produced") (:end . 68)\n  (:start . 60) (:id . 52))\n ((:tag . "NN") (:stem . "ion") (:form . "ion") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 77) (:start . 73)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 79) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 89)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "weight") (:form . "weight") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "CD") (:stem . "136") (:form . "136") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . "NN") (:stem . "adenine") (:form . "adenine") (:end . 112)\n  (:start . 105) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 114) (:start . 113)\n  (:id . 63))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 138)\n  (:start . 130) (:id . 67))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 141) (:start . 139)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MS") (:form . "MS") (:end . 144) (:start . 142)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s7.330) (:did . :pmc1135298) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102460@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s8.2) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102461@unknown@formal@none@1@S@Key components of the programmed cell death pathway are conserved between Caenorhabditis elegans, Drosophila melanogaster and humans.@(((:tag . "NN") (:stem . "key") (:form . "Key") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 32)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 51)\n  (:start . 44) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 55) (:start . 52)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 65)\n  (:start . 56) (:id . 51))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "Caenorhabditis") (:form . "Caenorhabditis")\n  (:end . 88) (:start . 74) (:id . 53))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 96)\n  (:start . 89) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 108)\n  (:start . 98) (:id . 56))\n ((:tag . "NN") (:stem . "melanogaster") (:form . "melanogaster") (:end . 121)\n  (:start . 109) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 132)\n  (:start . 126) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s8.3) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102462@unknown@formal@none@1@S@The search for additional homologs has been facilitated by the availability of the entire genomic sequence for each of these organisms.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "search") (:form . "search") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 25)\n  (:start . 15) (:id . 45))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 43) (:start . 39)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "facilitate") (:form . "facilitated") (:end . 55)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "NN") (:stem . "availability") (:form . "availability") (:end . 75)\n  (:start . 63) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 82) (:start . 79)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 89)\n  (:start . 83) (:id . 55))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 115) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 124)\n  (:start . 119) (:id . 61))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 134)\n  (:start . 125) (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.4) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102463@unknown@formal@none@1@S@Programmed cell death is a conserved, gene-directed mechanism for the elimination of unnecessary or dangerous cells from an organism.@(((:tag . "VBN") (:stem . "program") (:form . "Programmed") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 15) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 37) (:start . 36)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "gene-directed") (:form . "gene-directed")\n  (:end . 51) (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 69) (:start . 66)\n  (:id . 52))\n ((:tag . "NN") (:stem . "elimination") (:form . "elimination") (:end . 81)\n  (:start . 70) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 84) (:start . 82)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unnecessary") (:form . "unnecessary") (:end . 96)\n  (:start . 85) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 99) (:start . 97)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "dangerous") (:form . "dangerous") (:end . 109)\n  (:start . 100) (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 115)\n  (:start . 110) (:id . 58))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 120) (:start . 116)\n  (:id . 59))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 123) (:start . 121)\n  (:id . 60))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 132)\n  (:start . 124) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s8.5) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102464@unknown@formal@none@1@S@The core cell death pathway was first defined through genetic analysis in the nematode Caenorhabditis elegans and has since been found to be conserved in species as diverse as Drosophila melanogaster and Homo sapiens.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 31) (:start . 28)\n  (:id . 47))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 61)\n  (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "NN") (:stem . "nematode") (:form . "nematode") (:end . 86)\n  (:start . 78) (:id . 55))\n ((:tag . "NN") (:stem . "caenorhabditis") (:form . "Caenorhabditis")\n  (:end . 101) (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "elegan") (:form . "elegans") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 113) (:start . 110)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 117) (:start . 114)\n  (:id . 59))\n ((:tag . "RB") (:stem . "since") (:form . "since") (:end . 123)\n  (:start . 118) (:id . 60))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 128) (:start . 124)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 134)\n  (:start . 129) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 150)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 161)\n  (:start . 154) (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 164) (:start . 162)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "diverse") (:form . "diverse") (:end . 172)\n  (:start . 165) (:id . 69))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 175) (:start . 173)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 186)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "melanogaster") (:form . "melanogaster")\n  (:end . 199) (:start . 187) (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 203) (:start . 200)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Homo") (:form . "Homo") (:end . 208) (:start . 204)\n  (:id . 74))\n ((:tag . "NNS") (:stem . "sapien") (:form . "sapiens") (:end . 216)\n  (:start . 209) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 217) (:start . 216)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s8.6) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102465@unknown@formal@none@1@S@The rapid progress of the various genome sequencing projects has greatly accelerated the discovery of homologs for key components of the cell death pathway as well as for its regulators.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "progress") (:form . "progress") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . "NN") (:stem . "sequencing") (:form . "sequencing") (:end . 51)\n  (:start . 41) (:id . 49))\n ((:tag . "NNS") (:stem . "project") (:form . "projects") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "greatly") (:form . "greatly") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "VBN") (:stem . "accelerate") (:form . "accelerated") (:end . 84)\n  (:start . 73) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 88) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "discovery") (:form . "discovery") (:end . 98)\n  (:start . 89) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 110)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 114) (:start . 111)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 129)\n  (:start . 119) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 141) (:start . 137)\n  (:id . 63))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 147)\n  (:start . 142) (:id . 64))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 155)\n  (:start . 148) (:id . 65))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 163) (:start . 159)\n  (:id . 67))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 166) (:start . 164)\n  (:id . 68))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 170) (:start . 167)\n  (:id . 69))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 174) (:start . 171)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 185)\n  (:start . 175) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s8.7) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102466@unknown@formal@none@1@S@The C. elegans genome sequence was completed two years ago [1], and both the Drosophila [2] and human genomes are essentially completely sequenced at this point.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 14)\n  (:start . 7) (:id . 44))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 30)\n  (:start . 22) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 34) (:start . 31)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "complete") (:form . "completed") (:end . 44)\n  (:start . 35) (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 48) (:start . 45)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "year") (:form . "years") (:end . 54) (:start . 49)\n  (:id . 50))\n ((:tag . "RB") (:stem . "ago") (:form . "ago") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 62) (:start . 61)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 63) (:start . 62)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 67) (:start . 64)\n  (:id . 56))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 72) (:start . 68)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 76) (:start . 73)\n  (:id . 58))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 87)\n  (:start . 77) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 89) (:start . 88)\n  (:id . 60))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 90) (:start . 89)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 91) (:start . 90)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 95) (:start . 92)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 101) (:start . 96)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 109)\n  (:start . 102) (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 66))\n ((:tag . "RB") (:stem . "essentially") (:form . "essentially") (:end . 125)\n  (:start . 114) (:id . 67))\n ((:tag . "RB") (:stem . "completely") (:form . "completely") (:end . 136)\n  (:start . 126) (:id . 68))\n ((:tag . "VBN") (:stem . "sequence") (:form . "sequenced") (:end . 146)\n  (:start . 137) (:id . 69))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 149) (:start . 147)\n  (:id . 70))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 154) (:start . 150)\n  (:id . 71))\n ((:tag . "NN") (:stem . "point") (:form . "point") (:end . 160)\n  (:start . 155) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s8.8) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102467@unknown@formal@none@1@S@Although many components of the programmed cell death pathway are conserved between species, there are some important differences as well.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 13) (:start . 9)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 31) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 42)\n  (:start . 32) (:id . 47))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 47) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 53) (:start . 48)\n  (:id . 49))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 61)\n  (:start . 54) (:id . 50))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 75)\n  (:start . 66) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 83)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 92) (:start . 91)\n  (:id . 55))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 102) (:start . 99)\n  (:id . 57))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 107) (:start . 103)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . "NNS") (:stem . "difference") (:form . "differences") (:end . 129)\n  (:start . 118) (:id . 60))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 132) (:start . 130)\n  (:id . 61))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 138) (:start . 137)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.9) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102468@unknown@formal@none@1@S@The core cell death pathway@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 27)\n  (:start . 20) (:id . 46)))@@@1@5@((:identifiers (:sid . :s8.10) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102470@unknown@formal@none@1@S@Before this time, programmed cell death was defined by a set of specific morphological characteristics, including chromatin condensation, nuclear shrinkage and blebbing of the plasma membrane that could be observed in dying cells; the term apoptosis was coined to distinguish this type of cell death from necrotic deaths resulting from injury [3,4].@(((:tag . "IN") (:stem . "before") (:form . "Before") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 11) (:start . 7)\n  (:id . 43))\n ((:tag . "NN") (:stem . "time") (:form . "time") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "program") (:form . "programmed") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . 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5102471@unknown@formal@none@1@S@Four genes make up the core programmed cell death pathway in C. elegans, three of which, egl-1 (egg laying abnormal), ced-3 (cell death abnormal), and ced-4, are pro-apoptotic and one, ced-9, is anti-apoptotic (reviewed in [5]).@(((:tag . "CD") (:stem . "four") (:form . "Four") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "make") (:form . "make") (:end . 15) (:start . 11)\n  (:id . 44))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 18) (:start . 16)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "program") (:form . "programmed") (:end . 38)\n  (:start . 28) (:id . 48))\n ((:tag . "NN") (:stem . "cell") (:form . 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5102472@unknown@formal@none@1@S@There was considerable excitement in the field when potential mammalian and Drosophila homologs for ced-3, ced-4, ced-9, and egl-1 were discovered.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 22)\n  (:start . 10) (:id . 44))\n ((:tag . "NN") (:stem . "excitement") (:form . "excitement") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "field") (:form . "field") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 51) (:start . 47)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 61)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 71)\n  (:start . 62) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 75) (:start . 72)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 86)\n  (:start . 76) (:id . 53))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 95)\n  (:start . 87) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 99) (:start . 96)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ced-3") (:form . "ced-3") (:end . 105)\n  (:start . 100) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ced-4") (:form . "ced-4") (:end . 112)\n  (:start . 107) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ced-9") (:form . "ced-9") (:end . 119)\n  (:start . 114) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 124) (:start . 121)\n  (:id . 62))\n ((:tag . "NN") (:stem . "egl-1") (:form . "egl-1") (:end . 130)\n  (:start . 125) (:id . 63))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 146)\n  (:start . 136) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s8.14) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102473@unknown@formal@none@1@S@The CED-3 protein is one of a continuously growing family of specific cysteine proteases, termed caspases, that are thought to be the executioners of programmed cell death.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "ced-3") (:form . "CED-3") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "RB") (:stem . "continuously") (:form . "continuously") (:end . 42)\n  (:start . 30) (:id . 49))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "cysteine") (:form . "cysteine") (:end . 78)\n  (:start . 70) (:id . 54))\n ((:tag . "NNS") (:stem . "protease") (:form . "proteases") (:end . 88)\n  (:start . 79) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "term") (:form . "termed") (:end . 96) (:start . 90)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 105)\n  (:start . 97) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 59))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 111) (:start . 107)\n  (:id . 60))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 129) (:start . 127)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "executioner") (:form . "executioners") (:end . 146)\n  (:start . 134) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 160)\n  (:start . 150) (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 69))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 171)\n  (:start . 166) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x8.15.1) (:span 116 123)))\n (:hscopes ((:id . :x8.15.1) (:span 107 171)))\n (:identifiers (:sid . :s8.15) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102474@unknown@formal@none@1@S@At least fourteen mammalian caspases have been identified, and they are grouped into two classes on the basis of their proteolytic specificities (reviewed in [6]).@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "fourteen") (:form . "fourteen") (:end . 17)\n  (:start . 9) (:id . 44))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 27)\n  (:start . 18) (:id . 45))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 46) (:start . 42)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 57)\n  (:start . 47) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 58) (:start . 57)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "group") (:form . "grouped") (:end . 79)\n  (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 88) (:start . 85)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "class") (:form . "classes") (:end . 96)\n  (:start . 89) (:id . 57))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 59))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 109)\n  (:start . 104) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 61))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 118)\n  (:start . 113) (:id . 62))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 130)\n  (:start . 119) (:id . 63))\n ((:tag . "NNS") (:stem . "specificity") (:form . "specificities")\n  (:end . 144) (:start . 131) (:id . 64))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 154)\n  (:start . 146) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 157) (:start . 155)\n  (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 159) (:start . 158)\n  (:id . 68))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 160) (:start . 159)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 161) (:start . 160)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 162) (:start . 161)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 163) (:start . 162)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s8.16) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102475@unknown@formal@none@1@S@Class 1 caspases are mainly involved in cytokine maturation, while Class 2 caspases act mainly in apoptosis.@(((:tag . "NNP") (:stem . "Class") (:form . "Class") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 45))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 27)\n  (:start . 21) (:id . 46))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "cytokine") (:form . "cytokine") (:end . 48)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "maturation") (:form . "maturation") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 51))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 66) (:start . 61)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Class") (:form . "Class") (:end . 72) (:start . 67)\n  (:id . 53))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 74) (:start . 73)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "VBP") (:stem . "act") (:form . "act") (:end . 87) (:start . 84)\n  (:id . 56))\n ((:tag . "RB") (:stem . "mainly") (:form . "mainly") (:end . 94)\n  (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 108) (:start . 107)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s8.17) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102476@unknown@formal@none@1@S@Class 2 has been further subdivided into two groups: upstream or initiator caspases (group 1), and downstream or effector caspases (group 2).@(((:tag . "NNP") (:stem . "Class") (:form . "Class") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 24)\n  (:start . 17) (:id . 46))\n ((:tag . "VBN") (:stem . "subdivide") (:form . "subdivided") (:end . 35)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 51)\n  (:start . 45) (:id . 50))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 52) (:start . 51)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "upstream") (:form . "upstream") (:end . 61)\n  (:start . 53) (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 64) (:start . 62)\n  (:id . 53))\n ((:tag . "NN") (:stem . "initiator") (:form . "initiator") (:end . 74)\n  (:start . 65) (:id . 54))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 90) (:start . 85)\n  (:id . 57))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 92) (:start . 91)\n  (:id . 58))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 93) (:start . 92)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 94) (:start . 93)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "downstream") (:form . "downstream") (:end . 109)\n  (:start . 99) (:id . 62))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 112) (:start . 110)\n  (:id . 63))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 121)\n  (:start . 113) (:id . 64))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 130)\n  (:start . 122) (:id . 65))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 132) (:start . 131)\n  (:id . 66))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 137)\n  (:start . 132) (:id . 67))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 139) (:start . 138)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 141) (:start . 140)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s8.18) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102477@unknown@formal@none@1@S@Initiator caspases are thought to be at the beginning of a proteolytic cascade that amplifies the cell death signal and results in the activation of the effector caspases.@(((:tag . "NNP") (:stem . "Initiator") (:form . "Initiator") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 22) (:start . 19)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 30)\n  (:start . 23) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 33) (:start . 31)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "beginning") (:form . "beginning") (:end . 53)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "proteolytic") (:form . "proteolytic") (:end . 70)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "cascade") (:form . "cascade") (:end . 78)\n  (:start . 71) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 83) (:start . 79)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "amplify") (:form . "amplifies") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 57))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 58))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 108)\n  (:start . 103) (:id . 59))\n ((:tag . "NN") (:stem . "signal") (:form . "signal") (:end . 115)\n  (:start . 109) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 127)\n  (:start . 120) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 145)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 148) (:start . 146)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 67))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x8.19.1) (:span 23 30)))\n (:hscopes ((:id . :x8.19.1) (:span 0 170)))\n (:identifiers (:sid . :s8.19) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102478@unknown@formal@none@1@S@Initiator caspases usually have long pro-domains, while effector caspases have short pro-domains.@(((:tag . "NNP") (:stem . "Initiator") (:form . "Initiator") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 18)\n  (:start . 10) (:id . 43))\n ((:tag . "RB") (:stem . "usually") (:form . "usually") (:end . 26)\n  (:start . 19) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 36) (:start . 32)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "pro-domain") (:form . "pro-domains") (:end . 48)\n  (:start . 37) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 48))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 55) (:start . 50)\n  (:id . 49))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 64)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 73)\n  (:start . 65) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 78) (:start . 74)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 84) (:start . 79)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "pro-domain") (:form . "pro-domains") (:end . 96)\n  (:start . 85) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 97) (:start . 96)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s8.20) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102480@unknown@formal@none@1@S@C. elegans appears to have only a single caspase - CED-3 - that is essential for all developmental cell death, despite having three other caspases in its genome [8,9].@(((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 18)\n  (:start . 11) (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 48)\n  (:start . 41) (:id . 50))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 50) (:start . 49)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CED-3") (:form . "CED-3") (:end . 56) (:start . 51)\n  (:id . 52))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 58) (:start . 57)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 63) (:start . 59)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 66) (:start . 64)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 76)\n  (:start . 67) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 84) (:start . 81)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 98) (:start . 85) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 109)\n  (:start . 104) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "IN") (:stem . "despite") (:form . "despite") (:end . 118)\n  (:start . 111) (:id . 63))\n ((:tag . "VBG") (:stem . "have") (:form . "having") (:end . 125)\n  (:start . 119) (:id . 64))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 131)\n  (:start . 126) (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 137)\n  (:start . 132) (:id . 66))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 160)\n  (:start . 154) (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 162) (:start . 161)\n  (:id . 71))\n ((:tag . "CD") (:stem . "8,9") (:form . "8,9") (:end . 165) (:start . 162)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x8.22.1) (:span 11 18)))\n (:hscopes ((:id . :x8.22.1) (:span 0 109)))\n (:identifiers (:sid . :s8.22) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102481@unknown@formal@none@1@S@Three Drosophila caspases - Dcp-2/Dredd, Dronc, and one known only as a sequence in the genome database - have long pro-domains and are thus likely initiator caspases; another four - Dcp-1, drICE, Decay, and another one found in the genome database - have short pro-domains and are probably effector caspases.@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 25)\n  (:start . 17) (:id . 44))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 27) (:start . 26)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Dcp-2/Dredd") (:form . "Dcp-2/Dredd") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Dronc") (:form . "Dronc") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 61) (:start . 56)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 71) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 80)\n  (:start . 72) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 83) (:start . 81)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 94)\n  (:start . 88) (:id . 59))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 103)\n  (:start . 95) (:id . 60))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 105) (:start . 104)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 110) (:start . 106)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "long") (:form . "long") (:end . 115) (:start . 111)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "pro-domain") (:form . "pro-domains") (:end . 127)\n  (:start . 116) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 65))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 66))\n ((:tag . "RB") (:stem . "thus") (:form . "thus") (:end . 140) (:start . 136)\n  (:id . 67))\n ((:tag . "RB") (:stem . "likely") (:form . "likely") (:end . 147)\n  (:start . 141) (:id . 68))\n ((:tag . "NN") (:stem . "initiator") (:form . "initiator") (:end . 157)\n  (:start . 148) (:id . 69))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 166)\n  (:start . 158) (:id . 70))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 167) (:start . 166)\n  (:id . 71))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 175)\n  (:start . 168) (:id . 72))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 180) (:start . 176)\n  (:id . 73))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Dcp-1") (:form . "Dcp-1") (:end . 188)\n  (:start . 183) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 189) (:start . 188)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "drICE") (:form . "drICE") (:end . 195)\n  (:start . 190) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 196) (:start . 195)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Decay") (:form . "Decay") (:end . 202)\n  (:start . 197) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 203) (:start . 202)\n  (:id . 80))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 207) (:start . 204)\n  (:id . 81))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 215)\n  (:start . 208) (:id . 82))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 219) (:start . 216)\n  (:id . 83))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 225)\n  (:start . 220) (:id . 84))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 228) (:start . 226)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 232) (:start . 229)\n  (:id . 86))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 239)\n  (:start . 233) (:id . 87))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 248)\n  (:start . 240) (:id . 88))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 250) (:start . 249)\n  (:id . 89))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 255) (:start . 251)\n  (:id . 90))\n ((:tag . "JJ") (:stem . "short") (:form . "short") (:end . 261)\n  (:start . 256) (:id . 91))\n ((:tag . "NNS") (:stem . "pro-domain") (:form . "pro-domains") (:end . 273)\n  (:start . 262) (:id . 92))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 277) (:start . 274)\n  (:id . 93))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 281) (:start . 278)\n  (:id . 94))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 290)\n  (:start . 282) (:id . 95))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 299)\n  (:start . 291) (:id . 96))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 308)\n  (:start . 300) (:id . 97))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 309) (:start . 308)\n  (:id . 98)))@@@1@57@((:hcues ((:id . :x8.23.1) (:span 282 290))\n  ((:id . :x8.23.2) (:span 141 147)))\n (:hscopes ((:id . :x8.23.1) (:span 282 308))\n  ((:id . :x8.23.2) (:span 141 166)))\n (:identifiers (:sid . :s8.23) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102482@unknown@formal@none@1@S@In addition, Dcp-1 has a substrate specificity that is very similar to that of two effector caspases, mammalian caspase 3 and C. elegans CED-3 [10].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Dcp-1") (:form . "Dcp-1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 24) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 34)\n  (:start . 25) (:id . 48))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 46)\n  (:start . 35) (:id . 49))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 54) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 67)\n  (:start . 60) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 70) (:start . 68)\n  (:id . 54))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "effector") (:form . "effector") (:end . 91)\n  (:start . 83) (:id . 58))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 100)\n  (:start . 92) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 111)\n  (:start . 102) (:id . 61))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 119)\n  (:start . 112) (:id . 62))\n ((:tag . "CD") (:stem . "3") (:form . "3") (:end . 121) (:start . 120)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 128) (:start . 126)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 136)\n  (:start . 129) (:id . 66))\n ((:tag . "NNP") (:stem . "CED-3") (:form . "CED-3") (:end . 142)\n  (:start . 137) (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 144) (:start . 143)\n  (:id . 68))\n ((:tag . "CD") (:stem . "10") (:form . "10") (:end . 146) (:start . 144)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 147) (:start . 146)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s8.24) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102483@unknown@formal@none@1@S@Interestingly, Dronc appears to have a substrate specificity that is so far unique among caspases: while all other known caspases have only been shown to cleave after aspartate residues, Dronc can also cleave after glutamate residues [11].@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Dronc") (:form . "Dronc") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 28)\n  (:start . 21) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 46))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 60)\n  (:start . 49) (:id . 50))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "RB") (:stem . "far") (:form . "far") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "unique") (:form . "unique") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 88) (:start . 83)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 97)\n  (:start . 89) (:id . 57))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 104) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 114)\n  (:start . 109) (:id . 61))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 120)\n  (:start . 115) (:id . 62))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 129)\n  (:start . 121) (:id . 63))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 134) (:start . 130)\n  (:id . 64))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 139) (:start . 135)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 144) (:start . 140)\n  (:id . 66))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 150)\n  (:start . 145) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 153) (:start . 151)\n  (:id . 68))\n ((:tag . "VB") (:stem . "cleave") (:form . "cleave") (:end . 160)\n  (:start . 154) (:id . 69))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 166)\n  (:start . 161) (:id . 70))\n ((:tag . "NN") (:stem . "aspartate") (:form . "aspartate") (:end . 176)\n  (:start . 167) (:id . 71))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 185)\n  (:start . 177) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 186) (:start . 185)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Dronc") (:form . "Dronc") (:end . 192)\n  (:start . 187) (:id . 74))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . "VB") (:stem . "cleave") (:form . "cleave") (:end . 208)\n  (:start . 202) (:id . 77))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 214)\n  (:start . 209) (:id . 78))\n ((:tag . "NN") (:stem . "glutamate") (:form . "glutamate") (:end . 224)\n  (:start . 215) (:id . 79))\n ((:tag . "NNS") (:stem . "residue") (:form . "residues") (:end . 233)\n  (:start . 225) (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 235) (:start . 234)\n  (:id . 81))\n ((:tag . "CD") (:stem . "11") (:form . "11") (:end . 237) (:start . 235)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 238) (:start . 237)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x8.25.1) (:span 21 28)))\n (:hscopes ((:id . :x8.25.1) (:span 15 97)))\n (:identifiers (:sid . :s8.25) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102484@unknown@formal@none@1@S@This unusual substrate specificity may explain why Dronc is resistant to inhibition by the pan-caspase inhibitor p35.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "unusual") (:form . "unusual") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "substrate") (:form . "substrate") (:end . 22)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 34)\n  (:start . 23) (:id . 45))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 38) (:start . 35)\n  (:id . 46))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 46)\n  (:start . 39) (:id . 47))\n ((:tag . "WRB") (:stem . "why") (:form . "why") (:end . 50) (:start . 47)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Dronc") (:form . "Dronc") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "resistant") (:form . "resistant") (:end . 69)\n  (:start . 60) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 83)\n  (:start . 73) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 55))\n ((:tag . "NN") (:stem . "pan-caspase") (:form . "pan-caspase") (:end . 102)\n  (:start . 91) (:id . 56))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 112)\n  (:start . 103) (:id . 57))\n ((:tag . "NN") (:stem . "p35") (:form . "p35") (:end . 116) (:start . 113)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 117) (:start . 116)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x8.26.1) (:span 35 38)))\n (:hscopes ((:id . :x8.26.1) (:span 35 116)))\n (:identifiers (:sid . :s8.26) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102485@unknown@formal@none@1@S@On the basis of current data, it seems that CED-4 functions to help activate the caspase CED-3, and CED-9 blocks this activation through physical interaction with CED-4.@(((:tag . "IN") (:stem . "on") (:form . "On") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "current") (:form . "current") (:end . 23)\n  (:start . 16) (:id . 46))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 32) (:start . 30)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 38) (:start . 33)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 43) (:start . 39)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 49) (:start . 44)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 59)\n  (:start . 50) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 62) (:start . 60)\n  (:id . 54))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 67) (:start . 63)\n  (:id . 55))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 76)\n  (:start . 68) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 57))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 88)\n  (:start . 81) (:id . 58))\n ((:tag . "NN") (:stem . "ced-3") (:form . "CED-3") (:end . 94) (:start . 89)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 95) (:start . 94)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 99) (:start . 96)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "CED-9") (:form . "CED-9") (:end . 105)\n  (:start . 100) (:id . 62))\n ((:tag . "NNS") (:stem . "block") (:form . "blocks") (:end . 112)\n  (:start . 106) (:id . 63))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 128)\n  (:start . 118) (:id . 65))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 136)\n  (:start . 129) (:id . 66))\n ((:tag . "JJ") (:stem . "physical") (:form . "physical") (:end . 145)\n  (:start . 137) (:id . 67))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 157)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 162) (:start . 158)\n  (:id . 69))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 168)\n  (:start . 163) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 169) (:start . 168)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x8.27.1) (:span 33 38)))\n (:hscopes ((:id . :x8.27.1) (:span 33 168)))\n (:identifiers (:sid . :s8.27) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102486@unknown@formal@none@1@S@Endogenous CED-4 is normally localized to the mitochondria by CED-9, unless EGL-1 is expressed [12,13].@(((:tag . "JJ") (:stem . "endogenous") (:form . "Endogenous") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 16) (:start . 11)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 28)\n  (:start . 20) (:id . 45))\n ((:tag . "JJ") (:stem . "localized") (:form . "localized") (:end . 38)\n  (:start . 29) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "mitochondrion") (:form . "mitochondria")\n  (:end . 58) (:start . 46) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "CED-9") (:form . "CED-9") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "IN") (:stem . "unless") (:form . "unless") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . "NN") (:stem . "egl-1") (:form . "EGL-1") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 94)\n  (:start . 85) (:id . 56))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 96) (:start . 95)\n  (:id . 57))\n ((:tag . "CD") (:stem . "12,13") (:form . "12,13") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 102) (:start . 101)\n  (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s8.28) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102487@unknown@formal@none@1@S@If EGL-1 is expressed, the interaction between CED-4 and CED-9 ceases, and CED-4 translocates to the nuclear membrane where it activates CED-3, resulting in programmed cell death.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "egl-1") (:form . "EGL-1") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 21)\n  (:start . 12) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 38)\n  (:start . 27) (:id . 48))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 46)\n  (:start . 39) (:id . 49))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "CED-9") (:form . "CED-9") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "cease") (:form . "ceases") (:end . 69)\n  (:start . 63) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "translocate") (:form . "translocates") (:end . 93)\n  (:start . 81) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 100) (:start . 97)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 108)\n  (:start . 101) (:id . 60))\n ((:tag . "NN") (:stem . "membrane") (:form . "membrane") (:end . 117)\n  (:start . 109) (:id . 61))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 123)\n  (:start . 118) (:id . 62))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "activate") (:form . "activates") (:end . 136)\n  (:start . 127) (:id . 64))\n ((:tag . "NN") (:stem . "ced-3") (:form . "CED-3") (:end . 142)\n  (:start . 137) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 143) (:start . 142)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "result") (:form . "resulting") (:end . 153)\n  (:start . 144) (:id . 67))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 167)\n  (:start . 157) (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 172) (:start . 168)\n  (:id . 70))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 178)\n  (:start . 173) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 179) (:start . 178)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s8.29) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102488@unknown@formal@none@1@S@Only one mammalian CED-4 homolog, Apaf-1, has been extensively characterized to date, but it too aids in caspase activation.@(((:tag . "RB") (:stem . "only") (:form . "Only") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 24) (:start . 19)\n  (:id . 45))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "Apaf-1") (:form . "Apaf-1") (:end . 40)\n  (:start . 34) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 41) (:start . 40)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 45) (:start . 42)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 62)\n  (:start . 51) (:id . 52))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 76) (:start . 63) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 54))\n ((:tag . "NN") (:stem . "date") (:form . "date") (:end . 84) (:start . 80)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 89) (:start . 86)\n  (:id . 57))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "aid") (:form . "aids") (:end . 101) (:start . 97)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s8.30) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102490@unknown@formal@none@1@S@Knock-out studies have shown that mice deficient for Apaf-1 have reduced cell death in certain tissues, further supporting a role for Apaf-1 in programmed cell death.@(((:tag . "JJ") (:stem . "knock-out") (:form . "Knock-out") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 17)\n  (:start . 10) (:id . 43))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 28) (:start . 23)\n  (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "mouse") (:form . "mice") (:end . 38) (:start . 34)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "deficient") (:form . "deficient") (:end . 48)\n  (:start . 39) (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 52) (:start . 49)\n  (:id . 49))\n ((:tag . "NN") (:stem . "apaf-1") (:form . "Apaf-1") (:end . 59)\n  (:start . 53) (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 77) (:start . 73)\n  (:id . 53))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 83) (:start . 78)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 94)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "tissue") (:form . "tissues") (:end . 102)\n  (:start . 95) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "RB") (:stem . "further") (:form . "further") (:end . 111)\n  (:start . 104) (:id . 59))\n ((:tag . "VBG") (:stem . "support") (:form . "supporting") (:end . 122)\n  (:start . 112) (:id . 60))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 124) (:start . 123)\n  (:id . 61))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 133) (:start . 130)\n  (:id . 63))\n ((:tag . "NN") (:stem . "apaf-1") (:form . "Apaf-1") (:end . 140)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 154)\n  (:start . 144) (:id . 66))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 159) (:start . 155)\n  (:id . 67))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 165)\n  (:start . 160) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 166) (:start . 165)\n  (:id . 69)))@@@1@28@((:hcues ((:id . :x8.32.1) (:span 112 122)))\n (:hscopes ((:id . :x8.32.1) (:span 112 165)))\n (:identifiers (:sid . :s8.32) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102491@unknown@formal@none@1@S@Drosophila has recently been shown also to have a CED-4/Apaf-1 homolog, named Dark/HAC-1/Dapaf-1 (reviewed in [15]).@(((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 14) (:start . 11)\n  (:id . 43))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 47) (:start . 43)\n  (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "ced-4/apaf-1") (:form . "CED-4/Apaf-1") (:end . 62)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 70)\n  (:start . 63) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "name") (:form . "named") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "dark/hac-1/dapaf-1") (:form . "Dark/HAC-1/Dapaf-1")\n  (:end . 96) (:start . 78) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 98) (:start . 97)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 106)\n  (:start . 98) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 109) (:start . 107)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 111) (:start . 110)\n  (:id . 59))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 114) (:start . 113)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.33) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102492@unknown@formal@none@1@S@The Drosophila homolog is more similar to Apaf-1 than to CED-4: it has the WD repeats found in Apaf-1, which potentially function in binding regulatory proteins such as cytochrome c.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "NN") (:stem . "apaf-1") (:form . "Apaf-1") (:end . 48)\n  (:start . 42) (:id . 49))\n ((:tag . "IN") (:stem . "than") (:form . "than") (:end . 53) (:start . 49)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 56) (:start . 54)\n  (:id . 51))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 62) (:start . 57)\n  (:id . 52))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 63) (:start . 62)\n  (:id . 53))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "wd") (:form . "WD") (:end . 77) (:start . 75)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "repeat") (:form . "repeats") (:end . 85)\n  (:start . 78) (:id . 58))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 91) (:start . 86)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 94) (:start . 92)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Apaf-1") (:form . "Apaf-1") (:end . 101)\n  (:start . 95) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 108)\n  (:start . 103) (:id . 63))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 120)\n  (:start . 109) (:id . 64))\n ((:tag . "VBP") (:stem . "function") (:form . "function") (:end . 129)\n  (:start . 121) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 132) (:start . 130)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 140)\n  (:start . 133) (:id . 67))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 151)\n  (:start . 141) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 160)\n  (:start . 152) (:id . 69))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 165) (:start . 161)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 168) (:start . 166)\n  (:id . 71))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 179)\n  (:start . 169) (:id . 72))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 181) (:start . 180)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x8.34.1) (:span 109 120)))\n (:hscopes ((:id . :x8.34.1) (:span 109 181)))\n (:identifiers (:sid . :s8.34) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102493@unknown@formal@none@1@S@Like Apaf-1 and CED-4, loss of function mutations in dark/hac-1/dapaf-1 result in a reduction in developmental programmed cell death.@(((:tag . "IN") (:stem . "like") (:form . "Like") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "apaf-1") (:form . "Apaf-1") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 15) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 22) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "loss") (:form . "loss") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 39)\n  (:start . 31) (:id . 49))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 49)\n  (:start . 40) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "dark/hac-1/dapaf-1") (:form . "dark/hac-1/dapaf-1")\n  (:end . 71) (:start . 53) (:id . 52))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 78)\n  (:start . 72) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 83) (:start . 82)\n  (:id . 55))\n ((:tag . "NN") (:stem . "reduction") (:form . "reduction") (:end . 93)\n  (:start . 84) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 110) (:start . 97) (:id . 58))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 121)\n  (:start . 111) (:id . 59))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 126) (:start . 122)\n  (:id . 60))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 132)\n  (:start . 127) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 133) (:start . 132)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s8.35) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102494@unknown@formal@none@1@S@Intriguingly, the transcription of the Drosophila CED-4/Apaf-1 homolog is upregulated in response to both X-ray and ultraviolet irradiation, suggesting that death-inducing stimuli can feed into the cell death pathway at this step [16].@(((:tag . "RB") (:stem . "intriguingly") (:form . "Intriguingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 31) (:start . 18) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 34) (:start . 32)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 49)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "ced-4/apaf-1") (:form . "CED-4/Apaf-1") (:end . 62)\n  (:start . 50) (:id . 49))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 70)\n  (:start . 63) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 73) (:start . 71)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "upregulate") (:form . "upregulated") (:end . 85)\n  (:start . 74) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 53))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 97)\n  (:start . 89) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 55))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 105) (:start . 101)\n  (:id . 56))\n ((:tag . "NN") (:stem . "x-ray") (:form . "X-ray") (:end . 111)\n  (:start . 106) (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 58))\n ((:tag . "NN") (:stem . "ultraviolet") (:form . "ultraviolet") (:end . 127)\n  (:start . 116) (:id . 59))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 139)\n  (:start . 128) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 151)\n  (:start . 141) (:id . 62))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 156) (:start . 152)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "death-inducing") (:form . "death-inducing")\n  (:end . 171) (:start . 157) (:id . 64))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 179)\n  (:start . 172) (:id . 65))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 183) (:start . 180)\n  (:id . 66))\n ((:tag . "VB") (:stem . "feed") (:form . "feed") (:end . 188) (:start . 184)\n  (:id . 67))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 193) (:start . 189)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 197) (:start . 194)\n  (:id . 69))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 202) (:start . 198)\n  (:id . 70))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 208)\n  (:start . 203) (:id . 71))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 216)\n  (:start . 209) (:id . 72))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 219) (:start . 217)\n  (:id . 73))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 224) (:start . 220)\n  (:id . 74))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 229) (:start . 225)\n  (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 231) (:start . 230)\n  (:id . 76))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 233) (:start . 231)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 234) (:start . 233)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 79)))@@@1@38@((:hcues ((:id . :x8.36.1) (:span 180 183))\n  ((:id . :x8.36.2) (:span 141 151)))\n (:hscopes ((:id . :x8.36.1) (:span 180 229))\n  ((:id . :x8.36.2) (:span 141 229)))\n (:identifiers (:sid . :s8.36) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102495@unknown@formal@none@1@S@CED-9 and EGL-1 belong to a large family of proteins related to the mammalian anti-apoptotic protein Bcl-2.@(((:tag . "NNP") (:stem . "CED-9") (:form . "CED-9") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "EGL-1") (:form . "EGL-1") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "belong") (:form . "belong") (:end . 22)\n  (:start . 16) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 40)\n  (:start . 34) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 52)\n  (:start . 44) (:id . 51))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 77)\n  (:start . 68) (:id . 55))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 92) (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 100)\n  (:start . 93) (:id . 57))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 106)\n  (:start . 101) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s8.37) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102496@unknown@formal@none@1@S@This family - with at least 19 members, divided into pro- and anti-apoptotic subgroups - has been largely defined by protein-protein interactions among its members (reviewed in [17]).@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "CD") (:stem . "19") (:form . "19") (:end . 30) (:start . 28)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 38)\n  (:start . 31) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "divide") (:form . "divided") (:end . 47)\n  (:start . 40) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pro-") (:form . "pro-") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 76) (:start . 62) (:id . 55))\n ((:tag . "NNS") (:stem . "subgroup") (:form . "subgroups") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "HYPH") (:stem . "-") (:form . "-") (:end . 88) (:start . 87)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 97) (:start . 93)\n  (:id . 59))\n ((:tag . "RB") (:stem . "largely") (:form . "largely") (:end . 105)\n  (:start . 98) (:id . 60))\n ((:tag . "VBN") (:stem . "define") (:form . "defined") (:end . 113)\n  (:start . 106) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 132) (:start . 117) (:id . 63))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 145)\n  (:start . 133) (:id . 64))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 155) (:start . 152)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 163)\n  (:start . 156) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 173)\n  (:start . 165) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 178) (:start . 177)\n  (:id . 71))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 180) (:start . 178)\n  (:id . 72))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 181) (:start . 180)\n  (:id . 73))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s8.38) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102497@unknown@formal@none@1@S@CED-9 has mammalian counterparts in the anti-apoptotic subgroup of Bcl-2 family members, while EGL-1 has mammalian counterparts in the pro-apoptotic subgroup.@(((:tag . "NNP") (:stem . "CED-9") (:form . "CED-9") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 19)\n  (:start . 10) (:id . 44))\n ((:tag . "NNS") (:stem . "counterpart") (:form . "counterparts") (:end . 32)\n  (:start . 20) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 35) (:start . 33)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 54) (:start . 40) (:id . 48))\n ((:tag . "NN") (:stem . "subgroup") (:form . "subgroup") (:end . 63)\n  (:start . 55) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 50))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 79)\n  (:start . 73) (:id . 52))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 87)\n  (:start . 80) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 54))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 94) (:start . 89)\n  (:id . 55))\n ((:tag . "NN") (:stem . "egl-1") (:form . "EGL-1") (:end . 100) (:start . 95)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 114)\n  (:start . 105) (:id . 58))\n ((:tag . "NNS") (:stem . "counterpart") (:form . "counterparts") (:end . 127)\n  (:start . 115) (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 148) (:start . 135) (:id . 62))\n ((:tag . "NN") (:stem . "subgroup") (:form . "subgroup") (:end . 157)\n  (:start . 149) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s8.39) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102498@unknown@formal@none@1@S@Besides binding to Apaf-1, just as CED-9 binds and thereby regulates CED-4 activity, mammalian Bcl-2 family members have been proposed to regulate mitochondrial homeostasis and the release of pro-apoptotic factors such as cytochrome c (reviewed in [17]).@(((:tag . "IN") (:stem . "besides") (:form . "Besides") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 15) (:start . 8)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Apaf-1") (:form . "Apaf-1") (:end . 25)\n  (:start . 19) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 46))\n ((:tag . "RB") (:stem . "just") (:form . "just") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 34) (:start . 32)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "CED-9") (:form . "CED-9") (:end . 40) (:start . 35)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "bind") (:form . "binds") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 58)\n  (:start . 51) (:id . 52))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 68)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 74) (:start . 69)\n  (:id . 54))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 94)\n  (:start . 85) (:id . 57))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 100) (:start . 95)\n  (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 107)\n  (:start . 101) (:id . 59))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 115)\n  (:start . 108) (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 120) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 125) (:start . 121)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 134)\n  (:start . 126) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 137) (:start . 135)\n  (:id . 64))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 146)\n  (:start . 138) (:id . 65))\n ((:tag . "JJ") (:stem . "mitochondrial") (:form . "mitochondrial")\n  (:end . 160) (:start . 147) (:id . 66))\n ((:tag . "NN") (:stem . "homeostasis") (:form . "homeostasis") (:end . 172)\n  (:start . 161) (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 176) (:start . 173)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 69))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 188)\n  (:start . 181) (:id . 70))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 191) (:start . 189)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 205) (:start . 192) (:id . 72))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 213)\n  (:start . 206) (:id . 73))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 218) (:start . 214)\n  (:id . 74))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 221) (:start . 219)\n  (:id . 75))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 232)\n  (:start . 222) (:id . 76))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 234) (:start . 233)\n  (:id . 77))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 236) (:start . 235)\n  (:id . 78))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 244)\n  (:start . 236) (:id . 79))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 247) (:start . 245)\n  (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 249) (:start . 248)\n  (:id . 81))\n ((:tag . "CD") (:stem . "17") (:form . "17") (:end . 251) (:start . 249)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 252) (:start . 251)\n  (:id . 83))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 253) (:start . 252)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x8.40.1) (:span 126 134)))\n (:hscopes ((:id . :x8.40.1) (:span 85 234)))\n (:identifiers (:sid . :s8.40) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102500@unknown@formal@none@1@S@Indeed, most mitochondria released all their cytochrome c within a one minute period in a temperature-independent manner, suggesting that an enzymatic transport mechanism is probably not involved.@(((:tag . "RB") (:stem . "indeed") (:form . "Indeed") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "JJS") (:stem . "most") (:form . "most") (:end . 12) (:start . 8)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "mitochondrion") (:form . "mitochondria")\n  (:end . 25) (:start . 13) (:id . 45))\n ((:tag . "VBD") (:stem . "release") (:form . "released") (:end . 34)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 38) (:start . 35)\n  (:id . 47))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 44)\n  (:start . 39) (:id . 48))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 55)\n  (:start . 45) (:id . 49))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 57) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 64)\n  (:start . 58) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "NN") (:stem . "minute") (:form . "minute") (:end . 77)\n  (:start . 71) (:id . 54))\n ((:tag . "NN") (:stem . "period") (:form . "period") (:end . 84)\n  (:start . 78) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "temperature-independent")\n  (:form . "temperature-independent") (:end . 113) (:start . 90) (:id . 58))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 121) (:start . 120)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 140) (:start . 138)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "enzymatic") (:form . "enzymatic") (:end . 150)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "transport") (:form . "transport") (:end . 160)\n  (:start . 151) (:id . 65))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 170)\n  (:start . 161) (:id . 66))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 173) (:start . 171)\n  (:id . 67))\n ((:tag . "RB") (:stem . "probably") (:form . "probably") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 186) (:start . 183)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 195)\n  (:start . 187) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x8.42.2) (:span 174 182))\n  ((:id . :x8.42.3) (:span 122 132)))\n (:ncues ((:id . :x8.42.1) (:span 183 186)))\n (:hscopes ((:id . :x8.42.2) (:span 174 195))\n  ((:id . :x8.42.3) (:span 122 195)))\n (:nscopes ((:id . :x8.42.1) (:span 183 195)))\n (:identifiers (:sid . :s8.42) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102501@unknown@formal@none@1@S@There is no clear evidence for cytochrome c release during apoptosis in C. elegans or Drosophila, however.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 41)\n  (:start . 31) (:id . 48))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 51)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 58)\n  (:start . 52) (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 85) (:start . 83)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 96)\n  (:start . 86) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 58))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 105)\n  (:start . 98) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 106) (:start . 105)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x8.43.1) (:span 9 26)))\n (:hscopes ((:id . :x8.43.1) (:span 9 105)))\n (:identifiers (:sid . :s8.43) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102502@unknown@formal@none@1@S@Nevertheless, a specific epitope is uncovered on cytochrome c in Drosophila mitochondria during apoptosis and this may be sufficient to help activate Dark/HAC-1/Dapaf-1; and death-inducing stimuli result in an increase in cytochrome c in Drosophila cultured-cell lysates [19,20].@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 24)\n  (:start . 16) (:id . 45))\n ((:tag . "NN") (:stem . "epitope") (:form . "epitope") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 35) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "uncover") (:form . "uncovered") (:end . 45)\n  (:start . 36) (:id . 48))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 48) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 59)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 61) (:start . 60)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 75)\n  (:start . 65) (:id . 53))\n ((:tag . "NNS") (:stem . "mitochondrion") (:form . "mitochondria")\n  (:end . 88) (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 95)\n  (:start . 89) (:id . 55))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 105)\n  (:start . 96) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 57))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 118) (:start . 115)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 121) (:start . 119)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "sufficient") (:form . "sufficient") (:end . 132)\n  (:start . 122) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 135) (:start . 133)\n  (:id . 62))\n ((:tag . "VB") (:stem . "help") (:form . "help") (:end . 140) (:start . 136)\n  (:id . 63))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 149)\n  (:start . 141) (:id . 64))\n ((:tag . "NN") (:stem . "dark/hac-1/dapaf-1") (:form . "Dark/HAC-1/Dapaf-1")\n  (:end . 168) (:start . 150) (:id . 65))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 169) (:start . 168)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 173) (:start . 170)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "death-inducing") (:form . "death-inducing")\n  (:end . 188) (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 196)\n  (:start . 189) (:id . 69))\n ((:tag . "VBP") (:stem . "result") (:form . "result") (:end . 203)\n  (:start . 197) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 206) (:start . 204)\n  (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 209) (:start . 207)\n  (:id . 72))\n ((:tag . "NN") (:stem . "increase") (:form . "increase") (:end . 218)\n  (:start . 210) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 221) (:start . 219)\n  (:id . 74))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 232)\n  (:start . 222) (:id . 75))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 234) (:start . 233)\n  (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 237) (:start . 235)\n  (:id . 77))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 248)\n  (:start . 238) (:id . 78))\n ((:tag . "NN") (:stem . "cultured-cell") (:form . "cultured-cell")\n  (:end . 262) (:start . 249) (:id . 79))\n ((:tag . "NNS") (:stem . "lysate") (:form . "lysates") (:end . 270)\n  (:start . 263) (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 272) (:start . 271)\n  (:id . 81))\n ((:tag . "CD") (:stem . "19,20") (:form . "19,20") (:end . 277)\n  (:start . 272) (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 278) (:start . 277)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 279) (:start . 278)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x8.44.1) (:span 115 118)))\n (:hscopes ((:id . :x8.44.1) (:span 115 168)))\n (:identifiers (:sid . :s8.44) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102503@unknown@formal@none@1@S@There is no apparent need for cytochrome c release in C. elegans, since CED-4 does not require it to activate CED-3.@(((:tag . "EX") (:stem . "there") (:form . "There") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 8) (:start . 6)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "apparent") (:form . "apparent") (:end . 20)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "need") (:form . "need") (:end . 25) (:start . 21)\n  (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 40)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 50)\n  (:start . 43) (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 56) (:start . 54)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 64)\n  (:start . 57) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 54))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 71) (:start . 66)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ced-4") (:form . "CED-4") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 82) (:start . 78)\n  (:id . 57))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 94)\n  (:start . 87) (:id . 59))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 97) (:start . 95)\n  (:id . 60))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 100) (:start . 98)\n  (:id . 61))\n ((:tag . "VB") (:stem . "activate") (:form . "activate") (:end . 109)\n  (:start . 101) (:id . 62))\n ((:tag . "NNP") (:stem . "CED-3") (:form . "CED-3") (:end . 115)\n  (:start . 110) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x8.45.1) (:span 83 86)) ((:id . :x8.45.2) (:span 9 11)))\n (:nscopes ((:id . :x8.45.1) (:span 83 115)) ((:id . :x8.45.2) (:span 9 64)))\n (:identifiers (:sid . :s8.45) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102504@unknown@formal@none@1@S@Recently, a pro-apoptotic Drosophila Bcl-2 family member was identified with the help of the database of genomic sequence; this gene is most closely related to mammalian Bok and potentially regulates apoptosis in the fly [21,22,23,24].@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 25) (:start . 12) (:id . 45))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 36)\n  (:start . 26) (:id . 46))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 42) (:start . 37)\n  (:id . 47))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 49)\n  (:start . 43) (:id . 48))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 56)\n  (:start . 50) (:id . 49))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 60) (:start . 57)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 71)\n  (:start . 61) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 76) (:start . 72)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 80) (:start . 77)\n  (:id . 53))\n ((:tag . "NN") (:stem . "help") (:form . "help") (:end . 85) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 112)\n  (:start . 105) (:id . 59))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 121)\n  (:start . 113) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 122) (:start . 121)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 127) (:start . 123)\n  (:id . 62))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 132) (:start . 128)\n  (:id . 63))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 135) (:start . 133)\n  (:id . 64))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "RB") (:stem . "closely") (:form . "closely") (:end . 148)\n  (:start . 141) (:id . 66))\n ((:tag . "JJ") (:stem . "related") (:form . "related") (:end . 156)\n  (:start . 149) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 169)\n  (:start . 160) (:id . 69))\n ((:tag . "NNP") (:stem . "Bok") (:form . "Bok") (:end . 173) (:start . 170)\n  (:id . 70))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 189)\n  (:start . 178) (:id . 72))\n ((:tag . "VBZ") (:stem . "regulate") (:form . "regulates") (:end . 199)\n  (:start . 190) (:id . 73))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 209)\n  (:start . 200) (:id . 74))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 212) (:start . 210)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 76))\n ((:tag . "NN") (:stem . "fly") (:form . "fly") (:end . 220) (:start . 217)\n  (:id . 77))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 222) (:start . 221)\n  (:id . 78))\n ((:tag . "CD") (:stem . "21,22,23,24") (:form . "21,22,23,24") (:end . 233)\n  (:start . 222) (:id . 79))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 234) (:start . 233)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x8.46.1) (:span 178 189)))\n (:hscopes ((:id . :x8.46.1) (:span 178 220)))\n (:identifiers (:sid . :s8.46) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102505@unknown@formal@none@1@S@The Drosophila Bok homolog interacts with several anti-apoptotic, but not with several pro-apoptotic, Bcl-2 family members and, therefore, possibly functions by antagonizing pro-survival proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NNP") (:stem . "Bok") (:form . "Bok") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 36)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 41) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 49)\n  (:start . 42) (:id . 48))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 64) (:start . 50) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 65) (:start . 64)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 69) (:start . 66)\n  (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 73) (:start . 70)\n  (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 86)\n  (:start . 79) (:id . 54))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 100) (:start . 87) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 107)\n  (:start . 102) (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 114)\n  (:start . 108) (:id . 58))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 122)\n  (:start . 115) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 126) (:start . 123)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 61))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 137)\n  (:start . 128) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 147)\n  (:start . 139) (:id . 64))\n ((:tag . "VBZ") (:stem . "function") (:form . "functions") (:end . 157)\n  (:start . 148) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "antagonize") (:form . "antagonizing") (:end . 173)\n  (:start . 161) (:id . 67))\n ((:tag . "JJ") (:stem . "pro-survival") (:form . "pro-survival") (:end . 186)\n  (:start . 174) (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 195)\n  (:start . 187) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 196) (:start . 195)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x8.47.1) (:span 139 147)))\n (:ncues ((:id . :x8.47.2) (:span 70 73)))\n (:hscopes ((:id . :x8.47.1) (:span 139 195)))\n (:nscopes ((:id . :x8.47.2) (:span 70 122)))\n (:identifiers (:sid . :s8.47) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102506@unknown@formal@none@1@S@Ectopic expression of Bok protein promotes apoptosis in transgenic flies as well as in cultured cells.@(((:tag . "JJ") (:stem . "ectopic") (:form . "Ectopic") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 18)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 21) (:start . 19)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Bok") (:form . "Bok") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "VBZ") (:stem . "promote") (:form . "promotes") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 52)\n  (:start . 43) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 66)\n  (:start . 56) (:id . 50))\n ((:tag . "NNS") (:stem . "fly") (:form . "flies") (:end . 72) (:start . 67)\n  (:id . 51))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 75) (:start . 73)\n  (:id . 52))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 80) (:start . 76)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 86) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "culture") (:form . "cultured") (:end . 95)\n  (:start . 87) (:id . 56))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s8.48) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102507@unknown@formal@none@1@S@While one group reports that the caspase inhibitor p35 can block apoptosis induced by Drosophila Bok [22], another group did not see p35 inhibition [23].@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 9) (:start . 6)\n  (:id . 43))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "report") (:form . "reports") (:end . 23)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 40)\n  (:start . 33) (:id . 48))\n ((:tag . "NN") (:stem . "inhibitor") (:form . "inhibitor") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "p35") (:form . "p35") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 64) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 74)\n  (:start . 65) (:id . 53))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 82)\n  (:start . 75) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 85) (:start . 83)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 96)\n  (:start . 86) (:id . 56))\n ((:tag . "NNP") (:stem . "Bok") (:form . "Bok") (:end . 100) (:start . 97)\n  (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 102) (:start . 101)\n  (:id . 58))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 104) (:start . 102)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 105) (:start . 104)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 106) (:start . 105)\n  (:id . 61))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 114)\n  (:start . 107) (:id . 62))\n ((:tag . "NN") (:stem . "group") (:form . "group") (:end . 120)\n  (:start . 115) (:id . 63))\n ((:tag . "VBD") (:stem . "do") (:form . "did") (:end . 124) (:start . 121)\n  (:id . 64))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . "VB") (:stem . "see") (:form . "see") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "NN") (:stem . "p35") (:form . "p35") (:end . 136) (:start . 133)\n  (:id . 67))\n ((:tag . "NN") (:stem . "inhibition") (:form . "inhibition") (:end . 147)\n  (:start . 137) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "CD") (:stem . "23") (:form . "23") (:end . 151) (:start . 149)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 152) (:start . 151)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 72)))@@@1@31@((:ncues ((:id . :x8.49.1) (:span 125 128)))\n (:nscopes ((:id . :x8.49.1) (:span 125 147)))\n (:identifiers (:sid . :s8.49) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102508@unknown@formal@none@1@S@This difference may be due to the slightly different constructs used in the experiments and the different assay systems.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "MD") (:stem . "may") (:form . "may") (:end . 19) (:start . 16)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "due") (:form . "due") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "RB") (:stem . "slightly") (:form . "slightly") (:end . 42)\n  (:start . 34) (:id . 49))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 52)\n  (:start . 43) (:id . 50))\n ((:tag . "NNS") (:stem . "construct") (:form . "constructs") (:end . 63)\n  (:start . 53) (:id . 51))\n ((:tag . "VBN") (:stem . "use") (:form . "used") (:end . 68) (:start . 64)\n  (:id . 52))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 87)\n  (:start . 76) (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 91) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 95) (:start . 92)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 105)\n  (:start . 96) (:id . 58))\n ((:tag . "NN") (:stem . "assay") (:form . "assay") (:end . 111)\n  (:start . 106) (:id . 59))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 119)\n  (:start . 112) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x8.50.1) (:span 16 19)))\n (:hscopes ((:id . :x8.50.1) (:span 16 119)))\n (:identifiers (:sid . :s8.50) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102510@unknown@formal@none@1@S@Interestingly, ectopic expression of Drosophila Bok sensitizes the developing eye to cell death induced by ultraviolet irradiation [21].@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 22)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 33)\n  (:start . 23) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 47)\n  (:start . 37) (:id . 47))\n ((:tag . "NNP") (:stem . "Bok") (:form . "Bok") (:end . 51) (:start . 48)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "sensitize") (:form . "sensitizes") (:end . 62)\n  (:start . 52) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 77)\n  (:start . 67) (:id . 51))\n ((:tag . "NN") (:stem . "eye") (:form . "eye") (:end . 81) (:start . 78)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 84) (:start . 82)\n  (:id . 53))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 89) (:start . 85)\n  (:id . 54))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 95) (:start . 90)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 103)\n  (:start . 96) (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NN") (:stem . "ultraviolet") (:form . "ultraviolet") (:end . 118)\n  (:start . 107) (:id . 58))\n ((:tag . "NN") (:stem . "irradiation") (:form . "irradiation") (:end . 130)\n  (:start . 119) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 132) (:start . 131)\n  (:id . 60))\n ((:tag . "CD") (:stem . "21") (:form . "21") (:end . 134) (:start . 132)\n  (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 135) (:start . 134)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 136) (:start . 135)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.52) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102511@unknown@formal@none@1@S@Genetically, this Drosophila Bcl-2 family member appears to function upstream of, or in parallel to, the Drosophila ced-4/apaf-1 homolog and downstream of, or in parallel to, the Drosophila regulators of apoptosis, reaper, hid, and grim [22].@(((:tag . "RB") (:stem . "genetically") (:form . "Genetically") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 41)\n  (:start . 35) (:id . 47))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 48)\n  (:start . 42) (:id . 48))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 56)\n  (:start . 49) (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . "RB") (:stem . "upstream") (:form . "upstream") (:end . 77)\n  (:start . 69) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 80) (:start . 78)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 96)\n  (:start . 88) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 99) (:start . 97)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 100) (:start . 99)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 115)\n  (:start . 105) (:id . 61))\n ((:tag . "NN") (:stem . "ced-4/apaf-1") (:form . "ced-4/apaf-1") (:end . 128)\n  (:start . 116) (:id . 62))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "RB") (:stem . "downstream") (:form . "downstream") (:end . 151)\n  (:start . 141) (:id . 65))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 158) (:start . 156)\n  (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 69))\n ((:tag . "NN") (:stem . "parallel") (:form . "parallel") (:end . 170)\n  (:start . 162) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 173) (:start . 171)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 174) (:start . 173)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 189)\n  (:start . 179) (:id . 74))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 200)\n  (:start . 190) (:id . 75))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 203) (:start . 201)\n  (:id . 76))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 213)\n  (:start . 204) (:id . 77))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 214) (:start . 213)\n  (:id . 78))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 221)\n  (:start . 215) (:id . 79))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 222) (:start . 221)\n  (:id . 80))\n ((:tag . "NN") (:stem . "hid") (:form . "hid") (:end . 226) (:start . 223)\n  (:id . 81))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 227) (:start . 226)\n  (:id . 82))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 231) (:start . 228)\n  (:id . 83))\n ((:tag . "NN") (:stem . "grim") (:form . "grim") (:end . 236) (:start . 232)\n  (:id . 84))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 238) (:start . 237)\n  (:id . 85))\n ((:tag . "CD") (:stem . "22") (:form . "22") (:end . 240) (:start . 238)\n  (:id . 86))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 241) (:start . 240)\n  (:id . 87))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 242) (:start . 241)\n  (:id . 88)))@@@1@47@((:hcues ((:id . :x8.53.1) (:span 156 158)) ((:id . :x8.53.2) (:span 82 84))\n  ((:id . :x8.53.3) (:span 49 56)))\n (:hscopes ((:id . :x8.53.1) (:span 141 173)) ((:id . :x8.53.2) (:span 69 99))\n  ((:id . :x8.53.3) (:span 13 236)))\n (:identifiers (:sid . :s8.53) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102512@unknown@formal@none@1@S@The core components of the cell death pathway are illustrated in Figure 1.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 19)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 37) (:start . 32)\n  (:id . 48))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 45)\n  (:start . 38) (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 49) (:start . 46)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "illustrate") (:form . "illustrated") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 64) (:start . 62)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 71)\n  (:start . 65) (:id . 53))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 74) (:start . 73)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s8.54) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102513@unknown@formal@none@1@S@The core pathway of programmed cell death.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 16)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 30)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 42) (:start . 41)\n  (:id . 49)))@@@1@8@((:identifiers (:sid . :s8.55) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102514@unknown@formal@none@1@S@Multiple pathways lead to the activation of the executioners of death, the caspases (reviewed in [53]).@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "pathway") (:form . "pathways") (:end . 17)\n  (:start . 9) (:id . 43))\n ((:tag . "VBP") (:stem . "lead") (:form . "lead") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 25) (:start . 23)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 29) (:start . 26)\n  (:id . 46))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 40)\n  (:start . 30) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 43) (:start . 41)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "executioner") (:form . "executioners") (:end . 60)\n  (:start . 48) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 63) (:start . 61)\n  (:id . 51))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 83)\n  (:start . 75) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 93)\n  (:start . 85) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 98) (:start . 97)\n  (:id . 59))\n ((:tag . "CD") (:stem . "53") (:form . "53") (:end . 100) (:start . 98)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 101) (:start . 100)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 103) (:start . 102)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.56) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102515@unknown@formal@none@1@S@IAPs (inhibitors of apoptosis) have been shown to block the conversion of pro-caspases into active enzymes, and Reaper, Hid, Grim, and Diablo/Smac prevent IAPs from carrying out this protective function.@(((:tag . "NNP") (:stem . "IAP") (:form . "IAPs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 16)\n  (:start . 6) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 29)\n  (:start . 20) (:id . 46))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 49) (:start . 47)\n  (:id . 51))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 55) (:start . 50)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "conversion") (:form . "conversion") (:end . 70)\n  (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 73) (:start . 71)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "pro-caspas") (:form . "pro-caspases") (:end . 86)\n  (:start . 74) (:id . 56))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 98)\n  (:start . 92) (:id . 58))\n ((:tag . "NNS") (:stem . "enzyme") (:form . "enzymes") (:end . 106)\n  (:start . 99) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 118)\n  (:start . 112) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 123) (:start . 120)\n  (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 129) (:start . 125)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 130) (:start . 129)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 134) (:start . 131)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Diablo/Smac") (:form . "Diablo/Smac") (:end . 146)\n  (:start . 135) (:id . 69))\n ((:tag . "VBP") (:stem . "prevent") (:form . "prevent") (:end . 154)\n  (:start . 147) (:id . 70))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 159) (:start . 155)\n  (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 164) (:start . 160)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 173)\n  (:start . 165) (:id . 73))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 177) (:start . 174)\n  (:id . 74))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 182) (:start . 178)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "protective") (:form . "protective") (:end . 193)\n  (:start . 183) (:id . 76))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 202)\n  (:start . 194) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 203) (:start . 202)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s8.57) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102516@unknown@formal@none@1@S@Caspases can also be activated with the aid of Apaf-1, which in turn appears to be regulated by cytochrome c and dATP.@(((:tag . "NNS") (:stem . "caspas") (:form . "Caspases") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "activate") (:form . "activated") (:end . 30)\n  (:start . 21) (:id . 46))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "aid") (:form . "aid") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Apaf-1") (:form . "Apaf-1") (:end . 53)\n  (:start . 47) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 54) (:start . 53)\n  (:id . 52))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 60) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 54))\n ((:tag . "NN") (:stem . "turn") (:form . "turn") (:end . 68) (:start . 64)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 76)\n  (:start . 69) (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 92)\n  (:start . 83) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 95) (:start . 93)\n  (:id . 60))\n ((:tag . "NN") (:stem . "cytochrome") (:form . "cytochrome") (:end . 106)\n  (:start . 96) (:id . 61))\n ((:tag . "NN") (:stem . "c") (:form . "c") (:end . 108) (:start . 107)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 112) (:start . 109)\n  (:id . 63))\n ((:tag . "NN") (:stem . "datp") (:form . "dATP") (:end . 117) (:start . 113)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x8.58.1) (:span 69 76)))\n (:hscopes ((:id . :x8.58.1) (:span 55 117)))\n (:identifiers (:sid . :s8.58) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102517@unknown@formal@none@1@S@The Bcl-2 family appears to function in regulating the release of pro-apoptotic components from mitochondria as well as by possibly inhibiting Apaf-1 directly.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 16)\n  (:start . 10) (:id . 44))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 24)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "NN") (:stem . "release") (:form . "release") (:end . 62)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 65) (:start . 63)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 79) (:start . 66) (:id . 53))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 90)\n  (:start . 80) (:id . 54))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "mitochondrion") (:form . "mitochondria")\n  (:end . 108) (:start . 96) (:id . 56))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 111) (:start . 109)\n  (:id . 57))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 122) (:start . 120)\n  (:id . 60))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 131)\n  (:start . 123) (:id . 61))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "NN") (:stem . "apaf-1") (:form . "Apaf-1") (:end . 149)\n  (:start . 143) (:id . 63))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 158)\n  (:start . 150) (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x8.59.1) (:span 123 131)) ((:id . :x8.59.2) (:span 17 24)))\n (:hscopes ((:id . :x8.59.1) (:span 123 158))\n  ((:id . :x8.59.2) (:span 4 158)))\n (:identifiers (:sid . :s8.59) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102518@unknown@formal@none@1@S@This pathway integrates knowledge gained in multiple species, showing that apoptosis appears to be regulated in a similar manner regardless of the organism.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "integrate") (:form . "integrates") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 33)\n  (:start . 24) (:id . 45))\n ((:tag . "VBN") (:stem . "gain") (:form . "gained") (:end . 40) (:start . 34)\n  (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 43) (:start . 41)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "multiple") (:form . "multiple") (:end . 52)\n  (:start . 44) (:id . 48))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 60)\n  (:start . 53) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 69)\n  (:start . 62) (:id . 51))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 84)\n  (:start . 75) (:id . 53))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 92)\n  (:start . 85) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 95) (:start . 93)\n  (:id . 55))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 98) (:start . 96)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 108)\n  (:start . 99) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 121)\n  (:start . 114) (:id . 60))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 128)\n  (:start . 122) (:id . 61))\n ((:tag . "RB") (:stem . "regardless") (:form . "regardless") (:end . 139)\n  (:start . 129) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 142) (:start . 140)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 64))\n ((:tag . "NN") (:stem . "organism") (:form . "organism") (:end . 155)\n  (:start . 147) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x8.60.1) (:span 85 92)))\n (:hscopes ((:id . :x8.60.1) (:span 75 155)))\n (:identifiers (:sid . :s8.60) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102520@unknown@formal@none@1@S@Regulation of programmed cell death@(((:tag . "NN") (:stem . "regulation") (:form . "Regulation") (:end . 10)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 24)\n  (:start . 14) (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 29) (:start . 25)\n  (:id . 45))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 35) (:start . 30)\n  (:id . 46)))@@@1@5@((:identifiers (:sid . :s8.62) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102521@unknown@formal@none@1@S@Studies of Drosophila have yielded great insights into how programmed cell death is regulated (reviewed in [25]).@(((:tag . "NNPS") (:stem . "Study") (:form . "Studies") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 10) (:start . 8)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 21)\n  (:start . 11) (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "yield") (:form . "yielded") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "JJ") (:stem . "great") (:form . "great") (:end . 40) (:start . 35)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 49)\n  (:start . 41) (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 54) (:start . 50)\n  (:id . 49))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 58) (:start . 55)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 69)\n  (:start . 59) (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 52))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 80) (:start . 75)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 83) (:start . 81)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 93)\n  (:start . 84) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 95) (:start . 94)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 103)\n  (:start . 95) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 108) (:start . 107)\n  (:id . 59))\n ((:tag . "CD") (:stem . "25") (:form . "25") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 111) (:start . 110)\n  (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 113) (:start . 112)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.63) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102522@unknown@formal@none@1@S@In addition to the core pathway, several essential regulators have been characterized in Drosophila.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 23) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 31)\n  (:start . 24) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 32) (:start . 31)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 40)\n  (:start . 33) (:id . 49))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 50)\n  (:start . 41) (:id . 50))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 61)\n  (:start . 51) (:id . 51))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 66) (:start . 62)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 85) (:start . 72) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 99)\n  (:start . 89) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s8.64) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102523@unknown@formal@none@1@S@A region in the genome which contains the genes reaper, head involution defective (hid), and grim has been shown to be essential for virtually all developmental cell death in the Drosophila embryo.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 22)\n  (:start . 16) (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 28) (:start . 23)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 47) (:start . 42)\n  (:id . 50))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 54)\n  (:start . 48) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "head") (:form . "head") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "involution") (:form . "involution") (:end . 71)\n  (:start . 61) (:id . 54))\n ((:tag . "JJ") (:stem . "defective") (:form . "defective") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "hid") (:form . "hid") (:end . 86) (:start . 83)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 88) (:start . 87)\n  (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 60))\n ((:tag . "NN") (:stem . "grim") (:form . "grim") (:end . 97) (:start . 93)\n  (:id . 61))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 101) (:start . 98)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 106) (:start . 102)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 112)\n  (:start . 107) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 115) (:start . 113)\n  (:id . 65))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 118) (:start . 116)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 128)\n  (:start . 119) (:id . 67))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 132) (:start . 129)\n  (:id . 68))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 142)\n  (:start . 133) (:id . 69))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 146) (:start . 143)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 160) (:start . 147) (:id . 71))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 165) (:start . 161)\n  (:id . 72))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 171)\n  (:start . 166) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 174) (:start . 172)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 178) (:start . 175)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 189)\n  (:start . 179) (:id . 76))\n ((:tag . "NN") (:stem . "embryo") (:form . "embryo") (:end . 196)\n  (:start . 190) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 197) (:start . 196)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s8.65) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102524@unknown@formal@none@1@S@The three proteins encoded by these genes have no significant homology to any other known proteins except for a small stretch of similarity at the amino terminus that is shared by all three but no other known proteins.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 18)\n  (:start . 10) (:id . 44))\n ((:tag . "VBN") (:stem . "encode") (:form . "encoded") (:end . 26)\n  (:start . 19) (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 35) (:start . 30)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 41) (:start . 36)\n  (:id . 48))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 46) (:start . 42)\n  (:id . 49))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 49) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "significant") (:form . "significant") (:end . 61)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 70)\n  (:start . 62) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 53))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 77) (:start . 74)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 83) (:start . 78)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 89) (:start . 84)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 98)\n  (:start . 90) (:id . 57))\n ((:tag . "IN") (:stem . "except") (:form . "except") (:end . 105)\n  (:start . 99) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 111) (:start . 110)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 117)\n  (:start . 112) (:id . 61))\n ((:tag . "NN") (:stem . "stretch") (:form . "stretch") (:end . 125)\n  (:start . 118) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 128) (:start . 126)\n  (:id . 63))\n ((:tag . "NN") (:stem . "similarity") (:form . "similarity") (:end . 139)\n  (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 146) (:start . 143)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 152)\n  (:start . 147) (:id . 67))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 161)\n  (:start . 153) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 166) (:start . 162)\n  (:id . 69))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 169) (:start . 167)\n  (:id . 70))\n ((:tag . "VBN") (:stem . "share") (:form . "shared") (:end . 176)\n  (:start . 170) (:id . 71))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 179) (:start . 177)\n  (:id . 72))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 183) (:start . 180)\n  (:id . 73))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 189)\n  (:start . 184) (:id . 74))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 193) (:start . 190)\n  (:id . 75))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 196) (:start . 194)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 202)\n  (:start . 197) (:id . 77))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 208)\n  (:start . 203) (:id . 78))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 217)\n  (:start . 209) (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 218) (:start . 217)\n  (:id . 80)))@@@1@39@((:ncues ((:id . :x8.66.1) (:span 194 196)))\n (:nscopes ((:id . :x8.66.1) (:span 194 217)))\n (:identifiers (:sid . :s8.66) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102525@unknown@formal@none@1@S@Each of these three genes can induce programmed cell death when overexpressed in the developing Drosophila eye or in various tissue-culture assays.@(((:tag . "DT") (:stem . "each") (:form . "Each") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 7) (:start . 5)\n  (:id . 43))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 13) (:start . 8)\n  (:id . 44))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 19) (:start . 14)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 36)\n  (:start . 30) (:id . 48))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 47)\n  (:start . 37) (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 58) (:start . 53)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 63) (:start . 59)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 77) (:start . 64) (:id . 53))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 80) (:start . 78)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "develop") (:form . "developing") (:end . 95)\n  (:start . 85) (:id . 56))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 106)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "eye") (:form . "eye") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 113) (:start . 111)\n  (:id . 59))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 124)\n  (:start . 117) (:id . 61))\n ((:tag . "NN") (:stem . "tissue-culture") (:form . "tissue-culture")\n  (:end . 139) (:start . 125) (:id . 62))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 146)\n  (:start . 140) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s8.67) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102526@unknown@formal@none@1@S@In addition, Reaper, Hid and Grim are able to induce apoptosis in heterologous systems, suggesting that vertebrate homologs of these proteins exist (reviewed in [26]).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 24) (:start . 21)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 33) (:start . 29)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 37) (:start . 34)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 45) (:start . 43)\n  (:id . 52))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 52)\n  (:start . 46) (:id . 53))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 62)\n  (:start . 53) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 65) (:start . 63)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 78)\n  (:start . 66) (:id . 56))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 86)\n  (:start . 79) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 98)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 103) (:start . 99)\n  (:id . 60))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 114)\n  (:start . 104) (:id . 61))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 123)\n  (:start . 115) (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 126) (:start . 124)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 132)\n  (:start . 127) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 141)\n  (:start . 133) (:id . 65))\n ((:tag . "VBP") (:stem . "exist") (:form . "exist") (:end . 147)\n  (:start . 142) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 157)\n  (:start . 149) (:id . 68))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 162) (:start . 161)\n  (:id . 70))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 165) (:start . 164)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 74)))@@@1@33@((:hcues ((:id . :x8.68.1) (:span 88 98)))\n (:hscopes ((:id . :x8.68.1) (:span 88 147)))\n (:identifiers (:sid . :s8.68) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102527@unknown@formal@none@1@S@Further evidence for the existence of vertebrate homologs of Reaper, Hid, and Grim come from observations that these three proteins are able to bind a class of inhibitors of apoptosis, or IAPs.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 20) (:start . 17)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 45))\n ((:tag . "NN") (:stem . "existence") (:form . "existence") (:end . 34)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "NN") (:stem . "vertebrate") (:form . "vertebrate") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 57)\n  (:start . 49) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 67)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 68) (:start . 67)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 72) (:start . 69)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 82) (:start . 78)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "come") (:form . "come") (:end . 87) (:start . 83)\n  (:id . 57))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 92) (:start . 88)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 105)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 116)\n  (:start . 111) (:id . 61))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 122)\n  (:start . 117) (:id . 62))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 131)\n  (:start . 123) (:id . 63))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 135) (:start . 132)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 140) (:start . 136)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 143) (:start . 141)\n  (:id . 66))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 148) (:start . 144)\n  (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 150) (:start . 149)\n  (:id . 68))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 170)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 173) (:start . 171)\n  (:id . 72))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 183)\n  (:start . 174) (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 184) (:start . 183)\n  (:id . 74))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 187) (:start . 185)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAPs") (:end . 192) (:start . 188)\n  (:id . 76))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 77)))@@@1@36@((:identifiers (:sid . :s8.69) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102528@unknown@formal@none@1@S@IAPs were first discovered in baculovirus, but have since been shown to play a vital role in blocking apoptosis in Drosophila as well as in mammals (reviewed in [27]).@(((:tag . "NNP") (:stem . "IAP") (:form . "IAPs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "RB") (:stem . "first") (:form . "first") (:end . 15) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "discover") (:form . "discovered") (:end . 26)\n  (:start . 16) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "baculovirus") (:form . "baculovirus") (:end . 41)\n  (:start . 30) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 57) (:start . 52)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "VB") (:stem . "play") (:form . "play") (:end . 76) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 78) (:start . 77)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "vital") (:form . "vital") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 89) (:start . 85)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 92) (:start . 90)\n  (:id . 59))\n ((:tag . "VBG") (:stem . "block") (:form . "blocking") (:end . 101)\n  (:start . 93) (:id . 60))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 111)\n  (:start . 102) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 125)\n  (:start . 115) (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 128) (:start . 126)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 133) (:start . 129)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 136) (:start . 134)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 139) (:start . 137)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 149) (:start . 148)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 157)\n  (:start . 149) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 160) (:start . 158)\n  (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 162) (:start . 161)\n  (:id . 72))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 165) (:start . 164)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 166) (:start . 165)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s8.70) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102530@unknown@formal@none@1@S@More recently, reports of a potential functional mammalian analog of Reaper, Hid, and Grim have been published [30,31].@(((:tag . "RBR") (:stem . "more") (:form . "More") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 13)\n  (:start . 5) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "report") (:form . "reports") (:end . 22)\n  (:start . 15) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 27) (:start . 26)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 37)\n  (:start . 28) (:id . 48))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 58)\n  (:start . 49) (:id . 50))\n ((:tag . "NN") (:stem . "analog") (:form . "analog") (:end . 65)\n  (:start . 59) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 68) (:start . 66)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 75)\n  (:start . 69) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 85) (:start . 82)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 95) (:start . 91)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 100) (:start . 96)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 110)\n  (:start . 101) (:id . 61))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 112) (:start . 111)\n  (:id . 62))\n ((:tag . "CD") (:stem . "30,31") (:form . "30,31") (:end . 117)\n  (:start . 112) (:id . 63))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 119) (:start . 118)\n  (:id . 65)))@@@1@24@((:hcues ((:id . :x8.72.1) (:span 28 37)))\n (:hscopes ((:id . :x8.72.1) (:span 28 90)))\n (:identifiers (:sid . :s8.72) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102531@unknown@formal@none@1@S@Although Diablo/Smac shares no sequence homology with Reaper, Hid, or Grim, it too can bind IAPs, preventing them from inhibiting caspase activation, and thereby inducing apoptosis.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNP") (:stem . "Diablo/Smac") (:form . "Diablo/Smac") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "share") (:form . "shares") (:end . 27)\n  (:start . 21) (:id . 44))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 30) (:start . 28)\n  (:id . 45))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 39)\n  (:start . 31) (:id . 46))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 48)\n  (:start . 40) (:id . 47))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 60)\n  (:start . 54) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 65) (:start . 62)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 69) (:start . 67)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 74) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 75) (:start . 74)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 78) (:start . 76)\n  (:id . 56))\n ((:tag . "RB") (:stem . "too") (:form . "too") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 86) (:start . 83)\n  (:id . 58))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 91) (:start . 87)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 96) (:start . 92)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 108)\n  (:start . 98) (:id . 62))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 113) (:start . 109)\n  (:id . 63))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 118) (:start . 114)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 129)\n  (:start . 119) (:id . 65))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 137)\n  (:start . 130) (:id . 66))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 148)\n  (:start . 138) (:id . 67))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 149) (:start . 148)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 153) (:start . 150)\n  (:id . 69))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 161)\n  (:start . 154) (:id . 70))\n ((:tag . "VBG") (:stem . "induce") (:form . "inducing") (:end . 170)\n  (:start . 162) (:id . 71))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 180)\n  (:start . 171) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 73)))@@@1@32@((:ncues ((:id . :x8.73.1) (:span 28 30)))\n (:nscopes ((:id . :x8.73.1) (:span 28 74)))\n (:identifiers (:sid . :s8.73) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102532@unknown@formal@none@1@S@Furthermore, Diablo/Smac interacts through its amino terminus with the BIR (baculovirus IAP repeat) domains of IAPs, similar to Reaper, Hid, and Grim [32,33].@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Diablo/Smac") (:form . "Diablo/Smac") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "VBZ") (:stem . "interact") (:form . "interacts") (:end . 34)\n  (:start . 25) (:id . 45))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 42)\n  (:start . 35) (:id . 46))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 46) (:start . 43)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 52) (:start . 47)\n  (:id . 48))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 61)\n  (:start . 53) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "BIR") (:form . "BIR") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 76) (:start . 75)\n  (:id . 53))\n ((:tag . "NN") (:stem . "baculovirus") (:form . "baculovirus") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAP") (:end . 91) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "repeat") (:form . "repeat") (:end . 98)\n  (:start . 92) (:id . 56))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 99) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 107)\n  (:start . 100) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAPs") (:end . 115) (:start . 111)\n  (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 124)\n  (:start . 117) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 127) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 134)\n  (:start . 128) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 135) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 139) (:start . 136)\n  (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 140) (:start . 139)\n  (:id . 67))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 144) (:start . 141)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 149) (:start . 145)\n  (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 151) (:start . 150)\n  (:id . 70))\n ((:tag . "CD") (:stem . "32,33") (:form . "32,33") (:end . 156)\n  (:start . 151) (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 157) (:start . 156)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s8.74) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102533@unknown@formal@none@1@S@An important difference between the function of Diablo/Smac and Reaper, Hid, and Grim is that Diablo/Smac is not pro-apoptotic by itself when overexpressed, but instead requires a death-inducing stimulus to promote apoptosis, unlike the three Drosophila proteins.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "NN") (:stem . "difference") (:form . "difference") (:end . 23)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 35) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 44)\n  (:start . 36) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 47) (:start . 45)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Diablo/Smac") (:form . "Diablo/Smac") (:end . 59)\n  (:start . 48) (:id . 49))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 63) (:start . 60)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 70)\n  (:start . 64) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 71) (:start . 70)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 75) (:start . 72)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 85) (:start . 81)\n  (:id . 56))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 88) (:start . 86)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 93) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Diablo/Smac") (:form . "Diablo/Smac") (:end . 105)\n  (:start . 94) (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 108) (:start . 106)\n  (:id . 60))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "pro-apoptotic") (:form . "pro-apoptotic")\n  (:end . 126) (:start . 113) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 129) (:start . 127)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 136)\n  (:start . 130) (:id . 64))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 141) (:start . 137)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "overexpresse") (:form . "overexpressed")\n  (:end . 155) (:start . 142) (:id . 66))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 156) (:start . 155)\n  (:id . 67))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 160) (:start . 157)\n  (:id . 68))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 168)\n  (:start . 161) (:id . 69))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 177)\n  (:start . 169) (:id . 70))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 179) (:start . 178)\n  (:id . 71))\n ((:tag . "JJ") (:stem . "death-inducing") (:form . "death-inducing")\n  (:end . 194) (:start . 180) (:id . 72))\n ((:tag . "NN") (:stem . "stimulus") (:form . "stimulus") (:end . 203)\n  (:start . 195) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 206) (:start . 204)\n  (:id . 74))\n ((:tag . "VB") (:stem . "promote") (:form . "promote") (:end . 214)\n  (:start . 207) (:id . 75))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 224)\n  (:start . 215) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 225) (:start . 224)\n  (:id . 77))\n ((:tag . "IN") (:stem . "unlike") (:form . "unlike") (:end . 232)\n  (:start . 226) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 236) (:start . 233)\n  (:id . 79))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 242)\n  (:start . 237) (:id . 80))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 253)\n  (:start . 243) (:id . 81))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 262)\n  (:start . 254) (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 263) (:start . 262)\n  (:id . 83)))@@@1@42@((:ncues ((:id . :x8.75.1) (:span 109 112)))\n (:nscopes ((:id . :x8.75.1) (:span 109 155)))\n (:identifiers (:sid . :s8.75) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102534@unknown@formal@none@1@S@Table 1 provides a summary of the conserved regulators of cell death across species.@(((:tag . "JJ") (:stem . "table") (:form . "Table") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 7) (:start . 6)\n  (:id . 43))\n ((:tag . "VBZ") (:stem . "provide") (:form . "provides") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "NN") (:stem . "summary") (:form . "summary") (:end . 26)\n  (:start . 19) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 29) (:start . 27)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 43)\n  (:start . 34) (:id . 49))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 54)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "IN") (:stem . "across") (:form . "across") (:end . 75)\n  (:start . 69) (:id . 54))\n ((:tag . "NNS") (:stem . "specie") (:form . "species") (:end . 83)\n  (:start . 76) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:identifiers (:sid . :s8.76) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102535@unknown@formal@none@1@S@In contrast to cell death effectors such as caspases, the cell death regulators Reaper and Grim are specifically expressed several hours before apoptosis in cells destined to die (reviewed in [26]).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "contrast") (:form . "contrast") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "effector") (:form . "effectors") (:end . 35)\n  (:start . 26) (:id . 47))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 40) (:start . 36)\n  (:id . 48))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 52))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 62) (:start . 58)\n  (:id . 53))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 68) (:start . 63)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 79)\n  (:start . 69) (:id . 55))\n ((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 86)\n  (:start . 80) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 95) (:start . 91)\n  (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 99) (:start . 96)\n  (:id . 59))\n ((:tag . "RB") (:stem . "specifically") (:form . "specifically") (:end . 112)\n  (:start . 100) (:id . 60))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 122)\n  (:start . 113) (:id . 61))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 130)\n  (:start . 123) (:id . 62))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 143)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 153)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 156) (:start . 154)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 162)\n  (:start . 157) (:id . 67))\n ((:tag . "VBN") (:stem . "destine") (:form . "destined") (:end . 171)\n  (:start . 163) (:id . 68))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 174) (:start . 172)\n  (:id . 69))\n ((:tag . "VB") (:stem . "die") (:form . "die") (:end . 178) (:start . 175)\n  (:id . 70))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 180) (:start . 179)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 188)\n  (:start . 180) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 73))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 193) (:start . 192)\n  (:id . 74))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 195) (:start . 193)\n  (:id . 75))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 196) (:start . 195)\n  (:id . 76))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 197) (:start . 196)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s8.77) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102536@unknown@formal@none@1@S@The expression of reaper has been shown to be regulated by distinct stimuli, including X-irradiation, steroid hormone signaling and a block in cell differentiation ([34,35,36] and A.-F. Lambin and H.S., unpublished observations).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 24)\n  (:start . 18) (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 28) (:start . 25)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 55)\n  (:start . 46) (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 67)\n  (:start . 59) (:id . 53))\n ((:tag . "NNS") (:stem . "stimulus") (:form . "stimuli") (:end . 75)\n  (:start . 68) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 86)\n  (:start . 77) (:id . 56))\n ((:tag . "NNP") (:stem . "X-irradiation") (:form . "X-irradiation")\n  (:end . 100) (:start . 87) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 101) (:start . 100)\n  (:id . 58))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 109)\n  (:start . 102) (:id . 59))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 117)\n  (:start . 110) (:id . 60))\n ((:tag . "NN") (:stem . "signaling") (:form . "signaling") (:end . 127)\n  (:start . 118) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 133) (:start . 132)\n  (:id . 63))\n ((:tag . "NN") (:stem . "block") (:form . "block") (:end . 139)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 142) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "NN") (:stem . "differentiation") (:form . "differentiation")\n  (:end . 163) (:start . 148) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 165) (:start . 164)\n  (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 166) (:start . 165)\n  (:id . 69))\n ((:tag . "CD") (:stem . "34,35,36") (:form . "34,35,36") (:end . 174)\n  (:start . 166) (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 175) (:start . 174)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "A.-F.") (:form . "A.-F.") (:end . 185)\n  (:start . 180) (:id . 73))\n ((:tag . "NNP") (:stem . "Lambin") (:form . "Lambin") (:end . 192)\n  (:start . 186) (:id . 74))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 196) (:start . 193)\n  (:id . 75))\n ((:tag . "NNP") (:stem . "H.S.") (:form . "H.S.") (:end . 201) (:start . 197)\n  (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 214)\n  (:start . 203) (:id . 78))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 227)\n  (:start . 215) (:id . 79))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 228) (:start . 227)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 229) (:start . 228)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s8.78) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102537@unknown@formal@none@1@S@Recently, a Drosophila p53 ortholog was identified by searching the genome database (reviewed in [37]), and it was shown to bind a specific region of the reaper promoter, thereby potentially regulating reaper transcription in response to ionizing radiation.@(((:tag . "RB") (:stem . "recently") (:form . "Recently") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 22)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "p53") (:form . "p53") (:end . 26) (:start . 23)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ortholog") (:form . "ortholog") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 53) (:start . 51)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "search") (:form . "searching") (:end . 63)\n  (:start . 54) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 67) (:start . 64)\n  (:id . 52))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 74)\n  (:start . 68) (:id . 53))\n ((:tag . "NN") (:stem . "database") (:form . "database") (:end . 83)\n  (:start . 75) (:id . 54))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 85) (:start . 84)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 93)\n  (:start . 85) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 96) (:start . 94)\n  (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CD") (:stem . "37") (:form . "37") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 102) (:start . 101)\n  (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 63))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 110) (:start . 108)\n  (:id . 64))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 114) (:start . 111)\n  (:id . 65))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 120)\n  (:start . 115) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 123) (:start . 121)\n  (:id . 67))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 128) (:start . 124)\n  (:id . 68))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 130) (:start . 129)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 139)\n  (:start . 131) (:id . 70))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 146)\n  (:start . 140) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 73))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 160)\n  (:start . 154) (:id . 74))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 169)\n  (:start . 161) (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 76))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 178)\n  (:start . 171) (:id . 77))\n ((:tag . "RB") (:stem . "potentially") (:form . "potentially") (:end . 190)\n  (:start . 179) (:id . 78))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 201)\n  (:start . 191) (:id . 79))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 208)\n  (:start . 202) (:id . 80))\n ((:tag . "NN") (:stem . "transcription") (:form . "transcription")\n  (:end . 222) (:start . 209) (:id . 81))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 225) (:start . 223)\n  (:id . 82))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 234)\n  (:start . 226) (:id . 83))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 237) (:start . 235)\n  (:id . 84))\n ((:tag . "VBG") (:stem . "ionize") (:form . "ionizing") (:end . 246)\n  (:start . 238) (:id . 85))\n ((:tag . "NN") (:stem . "radiation") (:form . "radiation") (:end . 256)\n  (:start . 247) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 257) (:start . 256)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x8.79.1) (:span 179 190)))\n (:hscopes ((:id . :x8.79.1) (:span 179 256)))\n (:identifiers (:sid . :s8.79) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102538@unknown@formal@none@1@S@Furthermore, the reaper promoter was also shown to contain a response element for the complex made up of the steroid hormone ecdysone and its receptor [36].@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 23)\n  (:start . 17) (:id . 45))\n ((:tag . "NN") (:stem . "promoter") (:form . "promoter") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 41) (:start . 37)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 50))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 58)\n  (:start . 51) (:id . 51))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 52))\n ((:tag . "NN") (:stem . "response") (:form . "response") (:end . 69)\n  (:start . 61) (:id . 53))\n ((:tag . "NN") (:stem . "element") (:form . "element") (:end . 77)\n  (:start . 70) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 56))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 93)\n  (:start . 86) (:id . 57))\n ((:tag . "VBD") (:stem . "make") (:form . "made") (:end . 98) (:start . 94)\n  (:id . 58))\n ((:tag . "RP") (:stem . "up") (:form . "up") (:end . 101) (:start . 99)\n  (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 61))\n ((:tag . "NN") (:stem . "steroid") (:form . "steroid") (:end . 116)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "hormone") (:form . "hormone") (:end . 124)\n  (:start . 117) (:id . 63))\n ((:tag . "NN") (:stem . "ecdysone") (:form . "ecdysone") (:end . 133)\n  (:start . 125) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 141) (:start . 138)\n  (:id . 66))\n ((:tag . "NN") (:stem . "receptor") (:form . "receptor") (:end . 150)\n  (:start . 142) (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 152) (:start . 151)\n  (:id . 68))\n ((:tag . "CD") (:stem . "36") (:form . "36") (:end . 154) (:start . 152)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 155) (:start . 154)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s8.80) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102540@unknown@formal@none@1@S@Unlike reaper and grim, hid appears to be regulated not only transcriptionally but also post-translationally by the Ras-MAP kinase pathway [28,29].@(((:tag . "IN") (:stem . "unlike") (:form . "Unlike") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 13) (:start . 7)\n  (:id . 43))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "grim") (:form . "grim") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 23) (:start . 22)\n  (:id . 46))\n ((:tag . "NN") (:stem . "hid") (:form . "hid") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 41) (:start . 39)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "regulate") (:form . "regulated") (:end . 51)\n  (:start . 42) (:id . 51))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 55) (:start . 52)\n  (:id . 52))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 78) (:start . 61) (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 82) (:start . 79)\n  (:id . 55))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 87) (:start . 83)\n  (:id . 56))\n ((:tag . "RB") (:stem . "post-translationally")\n  (:form . "post-translationally") (:end . 108) (:start . 88) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 111) (:start . 109)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 115) (:start . 112)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "Ras-MAP") (:form . "Ras-MAP") (:end . 123)\n  (:start . 116) (:id . 60))\n ((:tag . "NNP") (:stem . "kinase") (:form . "kinase") (:end . 130)\n  (:start . 124) (:id . 61))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 138)\n  (:start . 131) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 140) (:start . 139)\n  (:id . 63))\n ((:tag . "CD") (:stem . "28,29") (:form . "28,29") (:end . 145)\n  (:start . 140) (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 146) (:start . 145)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 147) (:start . 146)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x8.82.1) (:span 28 35)))\n (:hscopes ((:id . :x8.82.1) (:span 24 138)))\n (:identifiers (:sid . :s8.82) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102541@unknown@formal@none@1@S@This additional level of control for hid could explain the observation that hid is expressed in cells that are doomed to die as well as in cells that continue to survive [38].@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 15)\n  (:start . 5) (:id . 43))\n ((:tag . "NN") (:stem . "level") (:form . "level") (:end . 21) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NN") (:stem . "control") (:form . "control") (:end . 32)\n  (:start . 25) (:id . 46))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NN") (:stem . "hid") (:form . "hid") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 46) (:start . 41)\n  (:id . 49))\n ((:tag . "VB") (:stem . "explain") (:form . "explain") (:end . 54)\n  (:start . 47) (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 58) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "observation") (:form . "observation") (:end . 70)\n  (:start . 59) (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 75) (:start . 71)\n  (:id . 53))\n ((:tag . "NN") (:stem . "hid") (:form . "hid") (:end . 79) (:start . 76)\n  (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 82) (:start . 80)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 95) (:start . 93)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 101) (:start . 96)\n  (:id . 58))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "doom") (:form . "doomed") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "VB") (:stem . "die") (:form . "die") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 127) (:start . 125)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 132) (:start . 128)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 135) (:start . 133)\n  (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 144)\n  (:start . 139) (:id . 68))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 149) (:start . 145)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "continue") (:form . "continue") (:end . 158)\n  (:start . 150) (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 161) (:start . 159)\n  (:id . 71))\n ((:tag . "VB") (:stem . "survive") (:form . "survive") (:end . 169)\n  (:start . 162) (:id . 72))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 171) (:start . 170)\n  (:id . 73))\n ((:tag . "CD") (:stem . "38") (:form . "38") (:end . 173) (:start . 171)\n  (:id . 74))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 174) (:start . 173)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 175) (:start . 174)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x8.83.1) (:span 41 46)))\n (:hscopes ((:id . :x8.83.1) (:span 41 169)))\n (:identifiers (:sid . :s8.83) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102542@unknown@formal@none@1@S@A second class of key apoptotic regulators in Drosophila is the IAP family.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "NN") (:stem . "class") (:form . "class") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "apoptotic") (:form . "apoptotic") (:end . 31)\n  (:start . 22) (:id . 47))\n ((:tag . "NNS") (:stem . "regulator") (:form . "regulators") (:end . 42)\n  (:start . 32) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 56)\n  (:start . 46) (:id . 50))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 59) (:start . 57)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAP") (:end . 67) (:start . 64)\n  (:id . 53))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 74)\n  (:start . 68) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 75) (:start . 74)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s8.84) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102543@unknown@formal@none@1@S@IAPs contain at least one, and up to three, BIR domains, which are important for protein-protein interactions, and often a carboxy-terminal RING domain (reviewed in [27]).@(((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 12)\n  (:start . 5) (:id . 43))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "RB") (:stem . "up") (:form . "up") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 50))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 42) (:start . 37)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "BIR") (:form . "BIR") (:end . 47) (:start . 44)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 55)\n  (:start . 48) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 56) (:start . 55)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 62) (:start . 57)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 66) (:start . 63)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 76)\n  (:start . 67) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 80) (:start . 77)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 96) (:start . 81) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 109)\n  (:start . 97) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 120)\n  (:start . 115) (:id . 64))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 122) (:start . 121)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 139) (:start . 123) (:id . 66))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 144) (:start . 140)\n  (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 151)\n  (:start . 145) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 153) (:start . 152)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 161)\n  (:start . 153) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 166) (:start . 165)\n  (:id . 72))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 168) (:start . 166)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 169) (:start . 168)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 170) (:start . 169)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s8.85) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102544@unknown@formal@none@1@S@While several IAPs have been implicated in inhibiting apoptosis, proteins with single BIR domains can also have functions in cell cycle regulation and cytokinesis [39,40].@(((:tag . "IN") (:stem . "while") (:form . "While") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "implicate") (:form . "implicated") (:end . 39)\n  (:start . 29) (:id . 47))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 53)\n  (:start . 43) (:id . 49))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 63)\n  (:start . 54) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 73)\n  (:start . 65) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 78) (:start . 74)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 85)\n  (:start . 79) (:id . 54))\n ((:tag . "NN") (:stem . "bir") (:form . "BIR") (:end . 89) (:start . 86)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "domain") (:form . "domains") (:end . 97)\n  (:start . 90) (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 106) (:start . 102)\n  (:id . 58))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 111) (:start . 107)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 129) (:start . 125)\n  (:id . 62))\n ((:tag . "NN") (:stem . "cycle") (:form . "cycle") (:end . 135)\n  (:start . 130) (:id . 63))\n ((:tag . "NN") (:stem . "regulation") (:form . "regulation") (:end . 146)\n  (:start . 136) (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 150) (:start . 147)\n  (:id . 65))\n ((:tag . "NN") (:stem . "cytokinesis") (:form . "cytokinesis") (:end . 162)\n  (:start . 151) (:id . 66))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 164) (:start . 163)\n  (:id . 67))\n ((:tag . "CD") (:stem . "39,40") (:form . "39,40") (:end . 169)\n  (:start . 164) (:id . 68))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 170) (:start . 169)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 171) (:start . 170)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s8.86) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102545@unknown@formal@none@1@S@In fact, Saccharomyces cerevisiae contains neither caspases nor an apoptotic program, but it does have an IAP-like protein with a single BIR domain that functions in regulating cell division [41], suggesting that the IAPs are diverse family with only some members being anti-apoptotic: hence this protein family is more accurately referred to as BIR-containing proteins (BIRPs).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 44))\n ((:tag . "NNP") (:stem . "Saccharomyces") (:form . "Saccharomyces")\n  (:end . 22) (:start . 9) (:id . 45))\n ((:tag . "NNP") (:stem . "cerevisiae") (:form . "cerevisiae") (:end . 33)\n  (:start . 23) (:id . 46))\n ((:tag . "VBZ") (:stem . "contain") (:form . "contains") (:end . 42)\n  (:start . 34) (:id . 47))\n ((:tag . 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(:end . 378) (:start . 377)\n  (:id . 106)))@@@1@65@((:hcues ((:id . :x8.87.1) (:span 197 207)))\n (:ncues ((:id . :x8.87.2) (:span 43 50 60 63)))\n (:hscopes ((:id . :x8.87.1) (:span 197 284)))\n (:nscopes ((:id . :x8.87.2) (:span 43 84)))\n (:identifiers (:sid . :s8.87) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102546@unknown@formal@none@1@S@Three Drosophila BIRPs have been shown to be inhibitors of apoptosis, Diap1, Diap2, and Deterin [42,43,44,45].@(((:tag . "CD") (:stem . "three") (:form . "Three") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 16)\n  (:start . 6) (:id . 43))\n ((:tag . "NNPS") (:stem . "BIRP") (:form . "BIRPs") (:end . 22) (:start . 17)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 27) (:start . 23)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 32) (:start . 28)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 38) (:start . 33)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 41) (:start . 39)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 44) (:start . 42)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "inhibitor") (:form . "inhibitors") (:end . 55)\n  (:start . 45) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 68)\n  (:start . 59) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "Diap1") (:form . "Diap1") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 76) (:start . 75)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Diap2") (:form . "Diap2") (:end . 82) (:start . 77)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "Deterin") (:form . "Deterin") (:end . 95)\n  (:start . 88) (:id . 59))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CD") (:stem . "42,43,44,45") (:form . "42,43,44,45") (:end . 108)\n  (:start . 97) (:id . 61))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 109) (:start . 108)\n  (:id . 62))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 110) (:start . 109)\n  (:id . 63)))@@@1@22@((:identifiers (:sid . :s8.88) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102547@unknown@formal@none@1@S@Of these, Diap1 has been most extensively characterized; it can block cell death caused by the ectopic expression of reaper, hid, and grim (reviewed in [26]).@(((:tag . "IN") (:stem . "of") (:form . "Of") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 44))\n ((:tag . "NNP") (:stem . "Diap1") (:form . "Diap1") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 24) (:start . 20)\n  (:id . 47))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 29) (:start . 25)\n  (:id . 48))\n ((:tag . "RB") (:stem . "extensively") (:form . "extensively") (:end . 41)\n  (:start . 30) (:id . 49))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 55) (:start . 42) (:id . 50))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 56) (:start . 55)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 59) (:start . 57)\n  (:id . 52))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 63) (:start . 60)\n  (:id . 53))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 69) (:start . 64)\n  (:id . 54))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 74) (:start . 70)\n  (:id . 55))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 80) (:start . 75)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "cause") (:form . "caused") (:end . 87)\n  (:start . 81) (:id . 57))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "ectopic") (:form . "ectopic") (:end . 102)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 113)\n  (:start . 103) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 116) (:start . 114)\n  (:id . 62))\n ((:tag . "NN") (:stem . "reaper") (:form . "reaper") (:end . 123)\n  (:start . 117) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 124) (:start . 123)\n  (:id . 64))\n ((:tag . "NN") (:stem . "hid") (:form . "hid") (:end . 128) (:start . 125)\n  (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 129) (:start . 128)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 133) (:start . 130)\n  (:id . 67))\n ((:tag . "NN") (:stem . "grim") (:form . "grim") (:end . 138) (:start . 134)\n  (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 140) (:start . 139)\n  (:id . 69))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 148)\n  (:start . 140) (:id . 70))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 71))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 153) (:start . 152)\n  (:id . 72))\n ((:tag . "CD") (:stem . "26") (:form . "26") (:end . 155) (:start . 153)\n  (:id . 73))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 156) (:start . 155)\n  (:id . 74))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 157) (:start . 156)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 158) (:start . 157)\n  (:id . 76)))@@@1@35@((:identifiers (:sid . :s8.89) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102548@unknown@formal@none@1@S@In addition, Diap1 is able to block the cell death induced by the Drosophila caspases Dcp-1 or drICE in Saccharomyces, as well as apoptosis induced by the expression of drICE in insect cell culture [46,47,48].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Diap1") (:form . "Diap1") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "able") (:form . "able") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 29) (:start . 27)\n  (:id . 48))\n ((:tag . "VB") (:stem . "block") (:form . "block") (:end . 35) (:start . 30)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 50))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 44) (:start . 40)\n  (:id . 51))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 50) (:start . 45)\n  (:id . 52))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 58)\n  (:start . 51) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 76)\n  (:start . 66) (:id . 56))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 85)\n  (:start . 77) (:id . 57))\n ((:tag . "NN") (:stem . "dcp-1") (:form . "Dcp-1") (:end . 91) (:start . 86)\n  (:id . 58))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 94) (:start . 92)\n  (:id . 59))\n ((:tag . "NN") (:stem . "drice") (:form . "drICE") (:end . 100) (:start . 95)\n  (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 103) (:start . 101)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Saccharomyces") (:form . "Saccharomyces")\n  (:end . 117) (:start . 104) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 118) (:start . 117)\n  (:id . 63))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 126) (:start . 122)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 129) (:start . 127)\n  (:id . 66))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 139)\n  (:start . 130) (:id . 67))\n ((:tag . "VBN") (:stem . "induce") (:form . "induced") (:end . 147)\n  (:start . 140) (:id . 68))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 150) (:start . 148)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 70))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 165)\n  (:start . 155) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 168) (:start . 166)\n  (:id . 72))\n ((:tag . "NN") (:stem . "drice") (:form . "drICE") (:end . 174)\n  (:start . 169) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 177) (:start . 175)\n  (:id . 74))\n ((:tag . "NN") (:stem . "insect") (:form . "insect") (:end . 184)\n  (:start . 178) (:id . 75))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 189) (:start . 185)\n  (:id . 76))\n ((:tag . "NN") (:stem . "culture") (:form . "culture") (:end . 197)\n  (:start . 190) (:id . 77))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 199) (:start . 198)\n  (:id . 78))\n ((:tag . "CD") (:stem . "46,47,48") (:form . "46,47,48") (:end . 207)\n  (:start . 199) (:id . 79))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 208) (:start . 207)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s8.90) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102550@unknown@formal@none@1@S@This phenotype is especially noteworthy since it manifests itself several hours before the first developmental cell deaths are normally observed in the Drosophila embryo, and it clearly shows that diap1 is vital for normal development.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "phenotype") (:form . "phenotype") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "RB") (:stem . "especially") (:form . "especially") (:end . 28)\n  (:start . 18) (:id . 45))\n ((:tag . "JJ") (:stem . "noteworthy") (:form . "noteworthy") (:end . 39)\n  (:start . 29) (:id . 46))\n ((:tag . "IN") (:stem . "since") (:form . "since") (:end . 45) (:start . 40)\n  (:id . 47))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 48) (:start . 46)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "manifest") (:form . "manifests") (:end . 58)\n  (:start . 49) (:id . 49))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 65)\n  (:start . 59) (:id . 50))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 73)\n  (:start . 66) (:id . 51))\n ((:tag . "NNS") (:stem . "hour") (:form . "hours") (:end . 79) (:start . 74)\n  (:id . 52))\n ((:tag . "IN") (:stem . "before") (:form . "before") (:end . 86)\n  (:start . 80) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 90) (:start . 87)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 96) (:start . 91)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "developmental") (:form . "developmental")\n  (:end . 110) (:start . 97) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 115) (:start . 111)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "death") (:form . "deaths") (:end . 122)\n  (:start . 116) (:id . 58))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 126) (:start . 123)\n  (:id . 59))\n ((:tag . "RB") (:stem . "normally") (:form . "normally") (:end . 135)\n  (:start . 127) (:id . 60))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 144)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 147) (:start . 145)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 162)\n  (:start . 152) (:id . 64))\n ((:tag . "NN") (:stem . "embryo") (:form . "embryo") (:end . 169)\n  (:start . 163) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 170) (:start . 169)\n  (:id . 66))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 67))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 185)\n  (:start . 178) (:id . 69))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 191)\n  (:start . 186) (:id . 70))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 196) (:start . 192)\n  (:id . 71))\n ((:tag . "NN") (:stem . "diap1") (:form . "diap1") (:end . 202)\n  (:start . 197) (:id . 72))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 205) (:start . 203)\n  (:id . 73))\n ((:tag . "JJ") (:stem . "vital") (:form . "vital") (:end . 211)\n  (:start . 206) (:id . 74))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 215) (:start . 212)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 222)\n  (:start . 216) (:id . 76))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 234)\n  (:start . 223) (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s8.92) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102551@unknown@formal@none@1@S@In general, IAPs are thought to function at the caspase activation step in the cell death pathway, binding to the inactive, pro-domain-containing caspase zymogen and preventing it from being processed into the active enzyme (reviewed in [27]).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "general") (:form . "general") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "think") (:form . "thought") (:end . 28)\n  (:start . 21) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 40)\n  (:start . 32) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 43) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 55)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 66)\n  (:start . 56) (:id . 53))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 74) (:start . 72)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 83) (:start . 79)\n  (:id . 57))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 89) (:start . 84)\n  (:id . 58))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 97)\n  (:start . 90) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 106)\n  (:start . 99) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 122)\n  (:start . 114) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "pro-domain-containing")\n  (:form . "pro-domain-containing") (:end . 145) (:start . 124) (:id . 66))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 153)\n  (:start . 146) (:id . 67))\n ((:tag . "NN") (:stem . "zymogen") (:form . "zymogen") (:end . 161)\n  (:start . 154) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 165) (:start . 162)\n  (:id . 69))\n ((:tag . "VBG") (:stem . "prevent") (:form . "preventing") (:end . 176)\n  (:start . 166) (:id . 70))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 179) (:start . 177)\n  (:id . 71))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 184) (:start . 180)\n  (:id . 72))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 190) (:start . 185)\n  (:id . 73))\n ((:tag . "VBN") (:stem . "process") (:form . "processed") (:end . 200)\n  (:start . 191) (:id . 74))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 205) (:start . 201)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 209) (:start . 206)\n  (:id . 76))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 216)\n  (:start . 210) (:id . 77))\n ((:tag . "NN") (:stem . "enzyme") (:form . "enzyme") (:end . 223)\n  (:start . 217) (:id . 78))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 225) (:start . 224)\n  (:id . 79))\n ((:tag . "VBN") (:stem . "review") (:form . "reviewed") (:end . 233)\n  (:start . 225) (:id . 80))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 236) (:start . 234)\n  (:id . 81))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 238) (:start . 237)\n  (:id . 82))\n ((:tag . "CD") (:stem . "27") (:form . "27") (:end . 240) (:start . 238)\n  (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 241) (:start . 240)\n  (:id . 84))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 242) (:start . 241)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 243) (:start . 242)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x8.93.1) (:span 21 28)))\n (:hscopes ((:id . :x8.93.1) (:span 12 223)))\n (:identifiers (:sid . :s8.93) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102552@unknown@formal@none@1@S@Reaper, Hid, Grim, and Diablo/Smac can physically interact with IAPs, thereby inhibiting the anti-apoptotic activity of IAPs and allowing caspase activation.@(((:tag . "NNP") (:stem . "Reaper") (:form . "Reaper") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "NNP") (:stem . "Hid") (:form . "Hid") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Grim") (:form . "Grim") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 18) (:start . 17)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 22) (:start . 19)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Diablo/Smac") (:form . "Diablo/Smac") (:end . 34)\n  (:start . 23) (:id . 49))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 38) (:start . 35)\n  (:id . 50))\n ((:tag . "RB") (:stem . "physically") (:form . "physically") (:end . 49)\n  (:start . 39) (:id . 51))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 63) (:start . 59)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAPs") (:end . 68) (:start . 64)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 55))\n ((:tag . "RB") (:stem . "thereby") (:form . "thereby") (:end . 77)\n  (:start . 70) (:id . 56))\n ((:tag . "VBG") (:stem . "inhibit") (:form . "inhibiting") (:end . 88)\n  (:start . 78) (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "anti-apoptotic") (:form . "anti-apoptotic")\n  (:end . 107) (:start . 93) (:id . 59))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 116)\n  (:start . 108) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 119) (:start . 117)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "VBG") (:stem . "allow") (:form . "allowing") (:end . 137)\n  (:start . 129) (:id . 64))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 145)\n  (:start . 138) (:id . 65))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 156)\n  (:start . 146) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 157) (:start . 156)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s8.94) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102553@unknown@formal@none@1@S@Further insight into a possible mechanism for IAP function was recently gained when IAPs were observed to have ubiquitin ligase activity [51,52].@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "insight") (:form . "insight") (:end . 15)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 20) (:start . 16)\n  (:id . 44))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 22) (:start . 21)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 31)\n  (:start . 23) (:id . 46))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 41)\n  (:start . 32) (:id . 47))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 45) (:start . 42)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAP") (:end . 49) (:start . 46)\n  (:id . 49))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 58)\n  (:start . 50) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 62) (:start . 59)\n  (:id . 51))\n ((:tag . "RB") (:stem . "recently") (:form . "recently") (:end . 71)\n  (:start . 63) (:id . 52))\n ((:tag . "VBN") (:stem . "gain") (:form . "gained") (:end . 78) (:start . 72)\n  (:id . 53))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 93) (:start . 89)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "observe") (:form . "observed") (:end . 102)\n  (:start . 94) (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 105) (:start . 103)\n  (:id . 58))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 110) (:start . 106)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ubiquitin") (:form . "ubiquitin") (:end . 120)\n  (:start . 111) (:id . 60))\n ((:tag . "NN") (:stem . "ligase") (:form . "ligase") (:end . 127)\n  (:start . 121) (:id . 61))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 136)\n  (:start . 128) (:id . 62))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 138) (:start . 137)\n  (:id . 63))\n ((:tag . "CD") (:stem . "51,52") (:form . "51,52") (:end . 143)\n  (:start . 138) (:id . 64))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 144) (:start . 143)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 145) (:start . 144)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x8.95.1) (:span 23 31)))\n (:hscopes ((:id . :x8.95.1) (:span 23 58)))\n (:identifiers (:sid . :s8.95) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102554@unknown@formal@none@1@S@It was shown that certain cellular IAPs can be degraded in a proteasome-dependent manner prior to thymocyte apoptosis.@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 12) (:start . 7)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "certain") (:form . "certain") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . "JJ") (:stem . "cellular") (:form . "cellular") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "NNS") (:stem . "iap") (:form . "IAPs") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "degrade") (:form . "degraded") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 58) (:start . 56)\n  (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "proteasome-dependent")\n  (:form . "proteasome-dependent") (:end . 81) (:start . 61) (:id . 54))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 88)\n  (:start . 82) (:id . 55))\n ((:tag . "JJ") (:stem . "prior") (:form . "prior") (:end . 94) (:start . 89)\n  (:id . 56))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 97) (:start . 95)\n  (:id . 57))\n ((:tag . "NN") (:stem . "thymocyte") (:form . "thymocyte") (:end . 107)\n  (:start . 98) (:id . 58))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 117)\n  (:start . 108) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 118) (:start . 117)\n  (:id . 60)))@@@1@19@((:identifiers (:sid . :s8.96) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102555@unknown@formal@none@1@S@These IAPs are also capable of auto-ubiquitination, an activity shown to require the RING domain [52].@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNPS") (:stem . "IAP") (:form . "IAPs") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 14) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "capable") (:form . "capable") (:end . 27)\n  (:start . 20) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NN") (:stem . "auto-ubiquitination")\n  (:form . "auto-ubiquitination") (:end . 50) (:start . 31) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 51) (:start . 50)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 63)\n  (:start . 55) (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 69) (:start . 64)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 80)\n  (:start . 73) (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 89) (:start . 85)\n  (:id . 56))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 96)\n  (:start . 90) (:id . 57))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 98) (:start . 97)\n  (:id . 58))\n ((:tag . "CD") (:stem . "52") (:form . "52") (:end . 100) (:start . 98)\n  (:id . 59))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 101) (:start . 100)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s8.97) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102556@unknown@formal@none@1@S@In addition, IAPs can mono-ubiquitinate several caspases in vitro, possibly marking them for degradation, and again, this activity requires the RING domain [51].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "IAP") (:form . "IAPs") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "VB") (:stem . "mono-ubiquitinate") (:form . "mono-ubiquitinate")\n  (:end . 39) (:start . 22) (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 47)\n  (:start . 40) (:id . 48))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 56)\n  (:start . 48) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 59) (:start . 57)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 65) (:start . 60)\n  (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 66) (:start . 65)\n  (:id . 52))\n ((:tag . "RB") (:stem . "possibly") (:form . "possibly") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "VBG") (:stem . "mark") (:form . "marking") (:end . 83)\n  (:start . 76) (:id . 54))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 88) (:start . 84)\n  (:id . 55))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "degradation") (:form . "degradation") (:end . 104)\n  (:start . 93) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 105) (:start . 104)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 109) (:start . 106)\n  (:id . 59))\n ((:tag . "RB") (:stem . "again") (:form . "again") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 61))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 121) (:start . 117)\n  (:id . 62))\n ((:tag . "NN") (:stem . "activity") (:form . "activity") (:end . 130)\n  (:start . 122) (:id . 63))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 139)\n  (:start . 131) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 143) (:start . 140)\n  (:id . 65))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 148) (:start . 144)\n  (:id . 66))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 155)\n  (:start . 149) (:id . 67))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 157) (:start . 156)\n  (:id . 68))\n ((:tag . "CD") (:stem . "51") (:form . "51") (:end . 159) (:start . 157)\n  (:id . 69))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 160) (:start . 159)\n  (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 161) (:start . 160)\n  (:id . 71)))@@@1@30@((:hcues ((:id . :x8.98.1) (:span 67 75)))\n (:hscopes ((:id . :x8.98.1) (:span 67 104)))\n (:identifiers (:sid . :s8.98) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102557@unknown@formal@none@1@S@The exact role of the ubiquitination pathway in regulating apoptosis is still unclear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "exact") (:form . "exact") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ubiquitination") (:form . "ubiquitination")\n  (:end . 36) (:start . 22) (:id . 47))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 44)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 47) (:start . 45)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 58)\n  (:start . 48) (:id . 50))\n ((:tag . "NN") (:stem . "apoptosis") (:form . "apoptosis") (:end . 68)\n  (:start . 59) (:id . 51))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 52))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 77) (:start . 72)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 55)))@@@1@14@((:hcues ((:id . :x8.99.1) (:span 78 85)))\n (:hscopes ((:id . :x8.99.1) (:span 0 85)))\n (:identifiers (:sid . :s8.99) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102558@unknown@formal@none@1@S@Even the role of the RING domain in IAPs is open to debate: mutations in the RING domain of endogenous diap1 can be either pro- or anti-apoptotic, depending on the death-inducing stimulus ([49] and J. Agapite, L. Goyal, K. McCall and H.S., unpublished observations).@(((:tag . "RB") (:stem . "even") (:form . "Even") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 16) (:start . 14)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "NN") (:stem . "ring") (:form . "RING") (:end . 25) (:start . 21)\n  (:id . 47))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 32)\n  (:start . 26) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . 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",") (:stem . ",") (:form . ",") (:end . 239) (:start . 238)\n  (:id . 91))\n ((:tag . "JJ") (:stem . "unpublished") (:form . "unpublished") (:end . 251)\n  (:start . 240) (:id . 92))\n ((:tag . "NNS") (:stem . "observation") (:form . "observations") (:end . 264)\n  (:start . 252) (:id . 93))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 265) (:start . 264)\n  (:id . 94))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 266) (:start . 265)\n  (:id . 95)))@@@1@54@((:hcues ((:id . :x8.100.1) (:span 116 122 128 130))\n  ((:id . :x8.100.3) (:span 109 112)))\n (:hscopes ((:id . :x8.100.1) (:span 116 145))\n  ((:id . :x8.100.3) (:span 109 145)))\n (:identifiers (:sid . :s8.100) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102560@unknown@formal@none@1@S@Strengths and limitations of genomic analysis@(((:tag . "NNS") (:stem . "strength") (:form . "Strengths") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 13) (:start . 10)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "limitation") (:form . "limitations") (:end . 25)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 36)\n  (:start . 29) (:id . 46))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 45)\n  (:start . 37) (:id . 47)))@@@1@6@((:identifiers (:sid . :s8.102) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102561@unknown@formal@none@1@S@The completed genomes of C. elegans and Drosophila have already yielded a wealth of information.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "complete") (:form . "completed") (:end . 13)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "genome") (:form . "genomes") (:end . 21)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 27) (:start . 25)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 35)\n  (:start . 28) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 50)\n  (:start . 40) (:id . 49))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 55) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 63)\n  (:start . 56) (:id . 51))\n ((:tag . "VBN") (:stem . "yield") (:form . "yielded") (:end . 71)\n  (:start . 64) (:id . 52))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 73) (:start . 72)\n  (:id . 53))\n ((:tag . "NN") (:stem . "wealth") (:form . "wealth") (:end . 80)\n  (:start . 74) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 96) (:start . 95)\n  (:id . 57)))@@@1@16@((:identifiers (:sid . :s8.103) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102562@unknown@formal@none@1@S@New cell death gene homologs are being described at a very rapid pace, often by several laboratories at once.@(((:tag . "JJ") (:stem . "new") (:form . "New") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 14) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 19) (:start . 15)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 28)\n  (:start . 20) (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 32) (:start . 29)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "be") (:form . "being") (:end . 38) (:start . 33)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "describe") (:form . "described") (:end . 48)\n  (:start . 39) (:id . 49))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 51) (:start . 49)\n  (:id . 50))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 53) (:start . 52)\n  (:id . 51))\n ((:tag . "RB") (:stem . "very") (:form . "very") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "rapid") (:form . "rapid") (:end . 64) (:start . 59)\n  (:id . 53))\n ((:tag . "NN") (:stem . "pace") (:form . "pace") (:end . 69) (:start . 65)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "RB") (:stem . "often") (:form . "often") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 79) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 87)\n  (:start . 80) (:id . 58))\n ((:tag . "NNS") (:stem . "laboratory") (:form . "laboratories") (:end . 100)\n  (:start . 88) (:id . 59))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 103) (:start . 101)\n  (:id . 60))\n ((:tag . "RB") (:stem . "once") (:form . "once") (:end . 108) (:start . 104)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 109) (:start . 108)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s8.104) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102563@unknown@formal@none@1@S@Using information from the genome project, C. elegans was shown to contain several potential caspases in addition to CED-3, but none of these has been shown to function in programmed cell death [9].@(((:tag . "VBG") (:stem . "use") (:form . "Using") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "information") (:form . "information") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 22) (:start . 18)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 33)\n  (:start . 27) (:id . 46))\n ((:tag . "NN") (:stem . "project") (:form . "project") (:end . 41)\n  (:start . 34) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 53)\n  (:start . 46) (:id . 50))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 57) (:start . 54)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 63) (:start . 58)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "contain") (:form . "contain") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 82)\n  (:start . 75) (:id . 55))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 92)\n  (:start . 83) (:id . 56))\n ((:tag . "NNS") (:stem . "caspas") (:form . "caspases") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 113)\n  (:start . 105) (:id . 59))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 116) (:start . 114)\n  (:id . 60))\n ((:tag . "NN") (:stem . "ced-3") (:form . "CED-3") (:end . 122)\n  (:start . 117) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 127) (:start . 124)\n  (:id . 63))\n ((:tag . "NN") (:stem . "none") (:form . "none") (:end . 132) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 135) (:start . 133)\n  (:id . 65))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 150) (:start . 146)\n  (:id . 68))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 156)\n  (:start . 151) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 159) (:start . 157)\n  (:id . 70))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 168)\n  (:start . 160) (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 171) (:start . 169)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 182)\n  (:start . 172) (:id . 73))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 187) (:start . 183)\n  (:id . 74))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 193)\n  (:start . 188) (:id . 75))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 195) (:start . 194)\n  (:id . 76))\n ((:tag . "CD") (:stem . "9") (:form . "9") (:end . 196) (:start . 195)\n  (:id . 77))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 197) (:start . 196)\n  (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 198) (:start . 197)\n  (:id . 79)))@@@1@38@((:ncues ((:id . :x8.105.1) (:span 128 132)))\n (:nscopes ((:id . :x8.105.1) (:span 128 193)))\n (:identifiers (:sid . :s8.105) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102564@unknown@formal@none@1@S@In addition, while C. elegans has two BIR-domain-containing proteins, neither appears to regulate cell death: BIR-1 has been demonstrated to be essential for cytokinesis instead [39].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 11)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "while") (:form . "while") (:end . 18) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 37) (:start . 34)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "bir-domain-containing")\n  (:form . "BIR-domain-containing") (:end . 59) (:start . 38) (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 68)\n  (:start . 60) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 52))\n ((:tag . "CC") (:stem . "neither") (:form . "neither") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "VB") (:stem . "regulate") (:form . "regulate") (:end . 97)\n  (:start . 89) (:id . 56))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 108)\n  (:start . 103) (:id . 58))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 109) (:start . 108)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "BIR-1") (:form . "BIR-1") (:end . 115)\n  (:start . 110) (:id . 60))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 119) (:start . 116)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 124) (:start . 120)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "demonstrate") (:form . "demonstrated") (:end . 137)\n  (:start . 125) (:id . 63))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 140) (:start . 138)\n  (:id . 64))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 143) (:start . 141)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 153)\n  (:start . 144) (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "cytokinesis") (:form . "cytokinesis") (:end . 169)\n  (:start . 158) (:id . 68))\n ((:tag . "RB") (:stem . "instead") (:form . "instead") (:end . 177)\n  (:start . 170) (:id . 69))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 179) (:start . 178)\n  (:id . 70))\n ((:tag . "CD") (:stem . "39") (:form . "39") (:end . 181) (:start . 179)\n  (:id . 71))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 182) (:start . 181)\n  (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 183) (:start . 182)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x8.106.2) (:span 78 85)))\n (:ncues ((:id . :x8.106.1) (:span 70 77)))\n (:hscopes ((:id . :x8.106.2) (:span 70 108)))\n (:nscopes ((:id . :x8.106.1) (:span 70 108)))\n (:identifiers (:sid . :s8.106) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102565@unknown@formal@none@1@S@Hence, C. elegans seems to have a mechanism for regulating caspase activation that differs from that of mammals and Drosophila, in that it relies solely on the two Bcl-2 family members [53].@(((:tag . "RB") (:stem . "hence") (:form . "Hence") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 17)\n  (:start . 10) (:id . 45))\n ((:tag . "VBZ") (:stem . "seem") (:form . "seems") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 47))\n ((:tag . "VB") (:stem . "have") (:form . "have") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 33) (:start . 32)\n  (:id . 49))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 43)\n  (:start . 34) (:id . 50))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 47) (:start . 44)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "regulate") (:form . "regulating") (:end . 58)\n  (:start . 48) (:id . 52))\n ((:tag . "NN") (:stem . "caspase") (:form . "caspase") (:end . 66)\n  (:start . 59) (:id . 53))\n ((:tag . "NN") (:stem . "activation") (:form . "activation") (:end . 77)\n  (:start . 67) (:id . 54))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 82) (:start . 78)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "differ") (:form . "differs") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 95) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 111)\n  (:start . 104) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 126)\n  (:start . 116) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 127) (:start . 126)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 138) (:start . 136)\n  (:id . 66))\n ((:tag . "VBZ") (:stem . "rely") (:form . "relies") (:end . 145)\n  (:start . 139) (:id . 67))\n ((:tag . "RB") (:stem . "solely") (:form . "solely") (:end . 152)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 155) (:start . 153)\n  (:id . 69))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 70))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 163) (:start . 160)\n  (:id . 71))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 169)\n  (:start . 164) (:id . 72))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 176)\n  (:start . 170) (:id . 73))\n ((:tag . "NNS") (:stem . "member") (:form . "members") (:end . 184)\n  (:start . 177) (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 186) (:start . 185)\n  (:id . 75))\n ((:tag . "CD") (:stem . "53") (:form . "53") (:end . 188) (:start . 186)\n  (:id . 76))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 189) (:start . 188)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x8.107.1) (:span 18 23)))\n (:hscopes ((:id . :x8.107.1) (:span 7 184)))\n (:identifiers (:sid . :s8.107) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102566@unknown@formal@none@1@S@For Drosophila, the genome project played a key role in the identification of the Bcl-2 family member(s) and the CED-4/Apaf-1 homolog, showing that the core cell death pathway is conserved in Drosophila as well.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 15) (:start . 14)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 26)\n  (:start . 20) (:id . 46))\n ((:tag . "NN") (:stem . "project") (:form . "project") (:end . 34)\n  (:start . 27) (:id . 47))\n ((:tag . "VBD") (:stem . "play") (:form . "played") (:end . 41) (:start . 35)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 43) (:start . 42)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "key") (:form . "key") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 52) (:start . 48)\n  (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 53))\n ((:tag . "NN") (:stem . "identification") (:form . "identification")\n  (:end . 74) (:start . 60) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 94)\n  (:start . 88) (:id . 58))\n ((:tag . "NNS") (:stem . "member(s)") (:form . "member(s)") (:end . 104)\n  (:start . 95) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 61))\n ((:tag . "NN") (:stem . "ced-4/apaf-1") (:form . "CED-4/Apaf-1") (:end . 125)\n  (:start . 113) (:id . 62))\n ((:tag . "NN") (:stem . "homolog") (:form . "homolog") (:end . 133)\n  (:start . 126) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 134) (:start . 133)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "show") (:form . "showing") (:end . 142)\n  (:start . 135) (:id . 65))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 147) (:start . 143)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 151) (:start . 148)\n  (:id . 67))\n ((:tag . "NN") (:stem . "core") (:form . "core") (:end . 156) (:start . 152)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 161) (:start . 157)\n  (:id . 69))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 167)\n  (:start . 162) (:id . 70))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 175)\n  (:start . 168) (:id . 71))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 178) (:start . 176)\n  (:id . 72))\n ((:tag . "VBN") (:stem . "conserve") (:form . "conserved") (:end . 188)\n  (:start . 179) (:id . 73))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 191) (:start . 189)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 202)\n  (:start . 192) (:id . 75))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 205) (:start . 203)\n  (:id . 76))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 210) (:start . 206)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s8.108) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102567@unknown@formal@none@1@S@Various other homologs for cell death genes, including three additional caspase-like sequences and a second Bcl-2 family member have been identified in the Drosophila genome sequence [7] and will undoubtedly be published in the near future.@(((:tag . "JJ") (:stem . "various") (:form . "Various") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 13) (:start . 8)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 22)\n  (:start . 14) (:id . 44))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 26) (:start . 23)\n  (:id . 45))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 31) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 37) (:start . 32)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 43) (:start . 38)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 44) (:start . 43)\n  (:id . 49))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 71)\n  (:start . 61) (:id . 52))\n ((:tag . "JJ") (:stem . "caspase-like") (:form . "caspase-like") (:end . 84)\n  (:start . 72) (:id . 53))\n ((:tag . "NNS") (:stem . "sequence") (:form . "sequences") (:end . 94)\n  (:start . 85) (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 98) (:start . 95)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 100) (:start . 99)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 107)\n  (:start . 101) (:id . 57))\n ((:tag . "NN") (:stem . "bcl-2") (:form . "Bcl-2") (:end . 113)\n  (:start . 108) (:id . 58))\n ((:tag . "NN") (:stem . "family") (:form . "family") (:end . 120)\n  (:start . 114) (:id . 59))\n ((:tag . "NN") (:stem . "member") (:form . "member") (:end . 127)\n  (:start . 121) (:id . 60))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 132) (:start . 128)\n  (:id . 61))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 137) (:start . 133)\n  (:id . 62))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 148)\n  (:start . 138) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 151) (:start . 149)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 155) (:start . 152)\n  (:id . 65))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 166)\n  (:start . 156) (:id . 66))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 173)\n  (:start . 167) (:id . 67))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 182)\n  (:start . 174) (:id . 68))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 184) (:start . 183)\n  (:id . 69))\n ((:tag . "CD") (:stem . "7") (:form . "7") (:end . 185) (:start . 184)\n  (:id . 70))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 186) (:start . 185)\n  (:id . 71))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 190) (:start . 187)\n  (:id . 72))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 195) (:start . 191)\n  (:id . 73))\n ((:tag . "RB") (:stem . "undoubtedly") (:form . "undoubtedly") (:end . 207)\n  (:start . 196) (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 210) (:start . 208)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "publish") (:form . "published") (:end . 220)\n  (:start . 211) (:id . 76))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 223) (:start . 221)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 227) (:start . 224)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "near") (:form . "near") (:end . 232) (:start . 228)\n  (:id . 79))\n ((:tag . "NN") (:stem . "future") (:form . "future") (:end . 239)\n  (:start . 233) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 240) (:start . 239)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s8.109) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102568@unknown@formal@none@1@S@And analysis of the human genomic sequence is sure to lead to a better understanding of the number of mammalian homologs for the various components of the cell death pathway.@(((:tag . "CC") (:stem . "and") (:form . "And") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "analysis") (:form . "analysis") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 19) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "human") (:form . "human") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "genomic") (:form . "genomic") (:end . 33)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 42)\n  (:start . 34) (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 45) (:start . 43)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "sure") (:form . "sure") (:end . 50) (:start . 46)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 53) (:start . 51)\n  (:id . 51))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 58) (:start . 54)\n  (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 61) (:start . 59)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 63) (:start . 62)\n  (:id . 54))\n ((:tag . "JJR") (:stem . "good") (:form . "better") (:end . 70) (:start . 64)\n  (:id . 55))\n ((:tag . "NN") (:stem . "understanding") (:form . "understanding")\n  (:end . 84) (:start . 71) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 58))\n ((:tag . "NN") (:stem . "number") (:form . "number") (:end . 98)\n  (:start . 92) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "mammalian") (:form . "mammalian") (:end . 111)\n  (:start . 102) (:id . 61))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 120)\n  (:start . 112) (:id . 62))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 124) (:start . 121)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 147)\n  (:start . 137) (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 150) (:start . 148)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 159) (:start . 155)\n  (:id . 69))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 165)\n  (:start . 160) (:id . 70))\n ((:tag . "NN") (:stem . "pathway") (:form . "pathway") (:end . 173)\n  (:start . 166) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 174) (:start . 173)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s8.110) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102570@unknown@formal@none@1@S@For instance, the small size of the Reaper protein - only of 65 amino acids - makes it extremely difficult to identify homologs on the basis of genomic sequence information in other species: current gene-finding programs typically require an open reading frame of at least 70 amino acids.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "instance") (:form . "instance") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "small") (:form . "small") (:end . 23) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "size") (:form . "size") (:end . 28) (:start . 24)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 31) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . 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"it") (:form . "it") (:end . 86) (:start . 84)\n  (:id . 60))\n ((:tag . "RB") (:stem . "extremely") (:form . "extremely") (:end . 96)\n  (:start . 87) (:id . 61))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 106)\n  (:start . 97) (:id . 62))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 109) (:start . 107)\n  (:id . 63))\n ((:tag . "VB") (:stem . "identify") (:form . "identify") (:end . 118)\n  (:start . 110) (:id . 64))\n ((:tag . "NNS") (:stem . "homolog") (:form . "homologs") (:end . 127)\n  (:start . 119) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 130) (:start . 128)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 134) (:start . 131)\n  (:id . 67))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 143) (:start . 141)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "genomic") (:form . 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5102571@unknown@formal@none@1@S@Furthermore, there is considerable divergence even among cell death proteins with clearly homologous functions, such as CED-4/Apaf-1 and even CED-9/Bcl-2, and sequence homology between these genes was recognized only after the genes and their products had been functionally characterized.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 18) (:start . 13)\n  (:id . 44))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "considerable") (:form . "considerable") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "NN") (:stem . "divergence") (:form . "divergence") (:end . 45)\n  (:start . 35) (:id . 47))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 50) (:start . 46)\n  (:id . 48))\n ((:tag . "IN") (:stem . "among") (:form . "among") (:end . 56) (:start . 51)\n  (:id . 49))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 61) (:start . 57)\n  (:id . 50))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 67) (:start . 62)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 76)\n  (:start . 68) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 81) (:start . 77)\n  (:id . 53))\n ((:tag . "RB") (:stem . "clearly") (:form . "clearly") (:end . 89)\n  (:start . 82) (:id . 54))\n ((:tag . "JJ") (:stem . "homologous") (:form . "homologous") (:end . 100)\n  (:start . 90) (:id . 55))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 110)\n  (:start . 101) (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 111) (:start . 110)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 116) (:start . 112)\n  (:id . 58))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 119) (:start . 117)\n  (:id . 59))\n ((:tag . "NN") (:stem . "ced-4/apaf-1") (:form . "CED-4/Apaf-1") (:end . 132)\n  (:start . 120) (:id . 60))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 136) (:start . 133)\n  (:id . 61))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 141) (:start . 137)\n  (:id . 62))\n ((:tag . "NN") (:stem . "ced-9/bcl-2") (:form . "CED-9/Bcl-2") (:end . 153)\n  (:start . 142) (:id . 63))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 158) (:start . 155)\n  (:id . 65))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 167)\n  (:start . 159) (:id . 66))\n ((:tag . "NN") (:stem . "homology") (:form . "homology") (:end . 176)\n  (:start . 168) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 184)\n  (:start . 177) (:id . 68))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 190)\n  (:start . 185) (:id . 69))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 196)\n  (:start . 191) (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 200) (:start . 197)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 211)\n  (:start . 201) (:id . 72))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 216) (:start . 212)\n  (:id . 73))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 222)\n  (:start . 217) (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 226) (:start . 223)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 232)\n  (:start . 227) (:id . 76))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 236) (:start . 233)\n  (:id . 77))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 242)\n  (:start . 237) (:id . 78))\n ((:tag . "NNS") (:stem . "product") (:form . "products") (:end . 251)\n  (:start . 243) (:id . 79))\n ((:tag . "VBD") (:stem . "have") (:form . "had") (:end . 255) (:start . 252)\n  (:id . 80))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 260) (:start . 256)\n  (:id . 81))\n ((:tag . "RB") (:stem . "functionally") (:form . "functionally") (:end . 273)\n  (:start . 261) (:id . 82))\n ((:tag . "VBN") (:stem . "characterize") (:form . "characterized")\n  (:end . 287) (:start . 274) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 288) (:start . 287)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s8.113) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102572@unknown@formal@none@1@S@Nevertheless, in combination with traditional approaches including genetics and biochemistry, knowledge of the genome sequence for model organisms will undoubtedly continue to drive our rapidly increasing insights into the molecular basis of programmed cell death.@(((:tag . "RB") (:stem . "nevertheless") (:form . "Nevertheless") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 16) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "combination") (:form . "combination") (:end . 28)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "traditional") (:form . "traditional") (:end . 45)\n  (:start . 34) (:id . 47))\n ((:tag . "NNS") (:stem . "approach") (:form . "approaches") (:end . 56)\n  (:start . 46) (:id . 48))\n ((:tag . "VBG") (:stem . "include") (:form . "including") (:end . 66)\n  (:start . 57) (:id . 49))\n ((:tag . "NNS") (:stem . "genetic") (:form . "genetics") (:end . 75)\n  (:start . 67) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 79) (:start . 76)\n  (:id . 51))\n ((:tag . "NN") (:stem . "biochemistry") (:form . "biochemistry") (:end . 92)\n  (:start . 80) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 93) (:start . 92)\n  (:id . 53))\n ((:tag . "NN") (:stem . "knowledge") (:form . "knowledge") (:end . 103)\n  (:start . 94) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 56))\n ((:tag . "NN") (:stem . "genome") (:form . "genome") (:end . 117)\n  (:start . 111) (:id . 57))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 126)\n  (:start . 118) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 130) (:start . 127)\n  (:id . 59))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 136)\n  (:start . 131) (:id . 60))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 146)\n  (:start . 137) (:id . 61))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 151) (:start . 147)\n  (:id . 62))\n ((:tag . "RB") (:stem . "undoubtedly") (:form . "undoubtedly") (:end . 163)\n  (:start . 152) (:id . 63))\n ((:tag . "VB") (:stem . "continue") (:form . "continue") (:end . 172)\n  (:start . 164) (:id . 64))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 175) (:start . 173)\n  (:id . 65))\n ((:tag . "VB") (:stem . "drive") (:form . "drive") (:end . 181)\n  (:start . 176) (:id . 66))\n ((:tag . "PRP$") (:stem . "our") (:form . "our") (:end . 185) (:start . 182)\n  (:id . 67))\n ((:tag . "RB") (:stem . "rapidly") (:form . "rapidly") (:end . 193)\n  (:start . 186) (:id . 68))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 204)\n  (:start . 194) (:id . 69))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 213)\n  (:start . 205) (:id . 70))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 218) (:start . 214)\n  (:id . 71))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 232)\n  (:start . 223) (:id . 73))\n ((:tag . "NN") (:stem . "basis") (:form . "basis") (:end . 238)\n  (:start . 233) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 241) (:start . 239)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "program") (:form . "programmed") (:end . 252)\n  (:start . 242) (:id . 76))\n ((:tag . "NN") (:stem . "cell") (:form . "cell") (:end . 257) (:start . 253)\n  (:id . 77))\n ((:tag . "NN") (:stem . "death") (:form . "death") (:end . 263)\n  (:start . 258) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 264) (:start . 263)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s8.114) (:did . :pmc138857) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102573@unknown@formal@none@1@S@Multiple RNA-protein interactions in Drosophila dosage compensation@(((:tag . "JJ") (:stem . "multiple") (:form . "Multiple") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "JJ") (:stem . "rna-protein") (:form . "RNA-protein") (:end . 20)\n  (:start . 9) (:id . 43))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 33)\n  (:start . 21) (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 36) (:start . 34)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 47)\n  (:start . 37) (:id . 46))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 54)\n  (:start . 48) (:id . 47))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 67)\n  (:start . 55) (:id . 48)))@@@1@7@((:identifiers (:sid . :s9.1) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Title|)))@oe@9-2-2011
5102574@unknown@formal@none@1@S@Abstract@(((:tag . "NN") (:stem . "abstract") (:form . "Abstract") (:end . 8)\n  (:start . 0) (:id . 42)))@@@1@1@((:identifiers (:sid . :s9.2) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102575@unknown@formal@none@1@S@From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "worm") (:form . "worms") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "human") (:form . "humans") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "recognize") (:form . "recognizing") (:end . 33)\n  (:start . 22) (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 37) (:start . 34)\n  (:id . 48))\n ((:tag . "VBG") (:stem . "modify") (:form . "modifying") (:end . 47)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 58)\n  (:start . 50) (:id . 51))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 69)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 72) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 82)\n  (:start . 73) (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 86) (:start . 83)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 93)\n  (:start . 87) (:id . 56))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 106)\n  (:start . 94) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 107) (:start . 106)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 59))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 121)\n  (:start . 112) (:id . 60))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 124) (:start . 122)\n  (:id . 61))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 130)\n  (:start . 125) (:id . 62))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 136)\n  (:start . 131) (:id . 63))\n ((:tag . "JJ") (:stem . "x-linked") (:form . "X-linked") (:end . 145)\n  (:start . 137) (:id . 64))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 150) (:start . 146)\n  (:id . 65))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 161)\n  (:start . 151) (:id . 66))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 164) (:start . 162)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 170)\n  (:start . 165) (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 174) (:start . 171)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 182)\n  (:start . 175) (:id . 70))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 185) (:start . 183)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 194)\n  (:start . 186) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 195) (:start . 194)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s9.3) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102576@unknown@formal@none@1@S@Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.@(((:tag . "JJ") (:stem . "recent") (:form . "Recent") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 16)\n  (:start . 7) (:id . 43))\n ((:tag . "JJ") (:stem . "genetic") (:form . "genetic") (:end . 24)\n  (:start . 17) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "biochemical") (:form . "biochemical") (:end . 40)\n  (:start . 29) (:id . 46))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 48)\n  (:start . 41) (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 53) (:start . 49)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 62)\n  (:start . 54) (:id . 49))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 66) (:start . 63)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 75)\n  (:start . 67) (:id . 51))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 80) (:start . 76)\n  (:id . 52))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 84) (:start . 81)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 95)\n  (:start . 85) (:id . 54))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 103)\n  (:start . 96) (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 106) (:start . 104)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 117)\n  (:start . 107) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 121) (:start . 118)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "recruit") (:form . "recruited") (:end . 131)\n  (:start . 122) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 135) (:start . 132)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 145)\n  (:start . 136) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 148) (:start . 146)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 152) (:start . 149)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 154) (:start . 153)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 165)\n  (:start . 155) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 166) (:start . 165)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "lead") (:form . "leading") (:end . 174)\n  (:start . 167) (:id . 67))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 177) (:start . 175)\n  (:id . 68))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 181) (:start . 178)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 191)\n  (:start . 182) (:id . 70))\n ((:tag . "NN") (:stem . "hypertranscription") (:form . "hypertranscription")\n  (:end . 210) (:start . 192) (:id . 71))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 213) (:start . 211)\n  (:id . 72))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 217) (:start . 214)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 223)\n  (:start . 218) (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 224) (:start . 223)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s9.4) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102577@unknown@formal@none@1@S@Distinct mechanisms of dosage compensation@(((:tag . "JJ") (:stem . "distinct") (:form . "Distinct") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "mechanism") (:form . "mechanisms") (:end . 19)\n  (:start . 9) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 22) (:start . 20)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 29)\n  (:start . 23) (:id . 45))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 42)\n  (:start . 30) (:id . 46)))@@@1@5@((:identifiers (:sid . :s9.5) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102578@unknown@formal@none@1@S@Dosage compensation, which ensures that the expression of X-linked genes is equal in males and females, is an essential process in organisms that have sex chromosomes.@(((:tag . "NNP") (:stem . "Dosage") (:form . "Dosage") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 19)\n  (:start . 7) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 20) (:start . 19)\n  (:id . 44))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 26) (:start . 21)\n  (:id . 45))\n ((:tag . "VBZ") (:stem . "ensure") (:form . "ensures") (:end . 34)\n  (:start . 27) (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 39) (:start . 35)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 48))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 54)\n  (:start . 44) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 57) (:start . 55)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "x-linked") (:form . "X-linked") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 72) (:start . 67)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 90) (:start . 85)\n  (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 94) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 102)\n  (:start . 95) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 106) (:start . 104)\n  (:id . 60))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 119)\n  (:start . 110) (:id . 62))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 127)\n  (:start . 120) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "organism") (:form . "organisms") (:end . 140)\n  (:start . 131) (:id . 65))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 145) (:start . 141)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 150) (:start . 146)\n  (:id . 67))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 154) (:start . 151)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 166)\n  (:start . 155) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 167) (:start . 166)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s9.6) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102580@unknown@formal@none@1@S@For example, in Caenorhabditis elegans, dosage compensation occurs in the homogametic hermaphrodite (XX) by the down-regulation of virtually all genes on the two X chromosomes by about 50%.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 15) (:start . 13)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Caenorhabditis") (:form . "Caenorhabditis")\n  (:end . 30) (:start . 16) (:id . 46))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 39) (:start . 38)\n  (:id . 48))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 46)\n  (:start . 40) (:id . 49))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 59)\n  (:start . 47) (:id . 50))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 66)\n  (:start . 60) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 73) (:start . 70)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "homogametic") (:form . "homogametic") (:end . 85)\n  (:start . 74) (:id . 54))\n ((:tag . "NN") (:stem . "hermaphrodite") (:form . "hermaphrodite")\n  (:end . 99) (:start . 86) (:id . 55))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 101) (:start . 100)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "XX") (:form . "XX") (:end . 103) (:start . 101)\n  (:id . 57))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 104) (:start . 103)\n  (:id . 58))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 107) (:start . 105)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 60))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 127) (:start . 112) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 130) (:start . 128)\n  (:id . 62))\n ((:tag . "RB") (:stem . "virtually") (:form . "virtually") (:end . 140)\n  (:start . 131) (:id . 63))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 144) (:start . 141)\n  (:id . 64))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 150)\n  (:start . 145) (:id . 65))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 153) (:start . 151)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 161) (:start . 158)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 163) (:start . 162)\n  (:id . 69))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 175)\n  (:start . 164) (:id . 70))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 178) (:start . 176)\n  (:id . 71))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 184)\n  (:start . 179) (:id . 72))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 187) (:start . 185)\n  (:id . 73))\n ((:tag . "NN") (:stem . "%") (:form . "%") (:end . 188) (:start . 187)\n  (:id . 74))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 75)))@@@1@34@((:identifiers (:sid . :s9.8) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102581@unknown@formal@none@1@S@In mammals, dosage compensation also occurs in the homogametic sex (the female) by X inactivation, whereby an entire X chromosome forms a distinct, heterochromatic, transcriptionally inactive nuclear structure known as the Barr body.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 18)\n  (:start . 12) (:id . 45))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 31)\n  (:start . 19) (:id . 46))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 36) (:start . 32)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "occur") (:form . "occurs") (:end . 43)\n  (:start . 37) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "homogametic") (:form . "homogametic") (:end . 62)\n  (:start . 51) (:id . 51))\n ((:tag . "NN") (:stem . "sex") (:form . "sex") (:end . 66) (:start . 63)\n  (:id . 52))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 68) (:start . 67)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . "NN") (:stem . "female") (:form . "female") (:end . 78)\n  (:start . 72) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 79) (:start . 78)\n  (:id . 56))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "NN") (:stem . "inactivation") (:form . "inactivation") (:end . 97)\n  (:start . 85) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 98) (:start . 97)\n  (:id . 60))\n ((:tag . "WRB") (:stem . "whereby") (:form . "whereby") (:end . 106)\n  (:start . 99) (:id . 61))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 109) (:start . 107)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 116)\n  (:start . 110) (:id . 63))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 118) (:start . 117)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 129)\n  (:start . 119) (:id . 65))\n ((:tag . "VBZ") (:stem . "form") (:form . "forms") (:end . 135)\n  (:start . 130) (:id . 66))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 137) (:start . 136)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "distinct") (:form . "distinct") (:end . 146)\n  (:start . 138) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 147) (:start . 146)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "heterochromatic") (:form . "heterochromatic")\n  (:end . 163) (:start . 148) (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 71))\n ((:tag . "RB") (:stem . "transcriptionally") (:form . "transcriptionally")\n  (:end . 182) (:start . 165) (:id . 72))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 191)\n  (:start . 183) (:id . 73))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 199)\n  (:start . 192) (:id . 74))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 209)\n  (:start . 200) (:id . 75))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 215)\n  (:start . 210) (:id . 76))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 218) (:start . 216)\n  (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 222) (:start . 219)\n  (:id . 78))\n ((:tag . "NNP") (:stem . "Barr") (:form . "Barr") (:end . 227) (:start . 223)\n  (:id . 79))\n ((:tag . "NN") (:stem . "body") (:form . "body") (:end . 232) (:start . 228)\n  (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 233) (:start . 232)\n  (:id . 81)))@@@1@40@((:identifiers (:sid . :s9.9) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102582@unknown@formal@none@1@S@Consequently, each gene on the single active X chromosome in female cells and the corresponding gene on the single X chromosome in male cells are expressed at equal levels.@(((:tag . "RB") (:stem . "consequently") (:form . "Consequently") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 18) (:start . 14)\n  (:id . 44))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 37)\n  (:start . 31) (:id . 48))\n ((:tag . "JJ") (:stem . "active") (:form . "active") (:end . 44)\n  (:start . 38) (:id . 49))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 57)\n  (:start . 47) (:id . 51))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 60) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "female") (:form . "female") (:end . 67)\n  (:start . 61) (:id . 53))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 73) (:start . 68)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "corresponding") (:form . "corresponding")\n  (:end . 95) (:start . 82) (:id . 57))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 100) (:start . 96)\n  (:id . 58))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 103) (:start . 101)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 107) (:start . 104)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 114)\n  (:start . 108) (:id . 61))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 116) (:start . 115)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 127)\n  (:start . 117) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 130) (:start . 128)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 135) (:start . 131)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 141)\n  (:start . 136) (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 145) (:start . 142)\n  (:id . 67))\n ((:tag . "VBN") (:stem . "express") (:form . "expressed") (:end . 155)\n  (:start . 146) (:id . 68))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 158) (:start . 156)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "equal") (:form . "equal") (:end . 164)\n  (:start . 159) (:id . 70))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 171)\n  (:start . 165) (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 172) (:start . 171)\n  (:id . 72)))@@@1@31@((:identifiers (:sid . :s9.10) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102583@unknown@formal@none@1@S@In Drosophila, dosage compensation is achieved in the heterogametic male by a twofold chromosome-wide up-regulation (hypertranscription) of essentially all genes on the single X chromosome.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 34)\n  (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "achieve") (:form . "achieved") (:end . 46)\n  (:start . 38) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 49) (:start . 47)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 53) (:start . 50)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "heterogametic") (:form . "heterogametic")\n  (:end . 67) (:start . 54) (:id . 51))\n ((:tag . "NN") (:stem . "male") (:form . "male") (:end . 72) (:start . 68)\n  (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 77) (:start . 76)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "twofold") (:form . "twofold") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "JJ") (:stem . "chromosome-wide") (:form . "chromosome-wide")\n  (:end . 101) (:start . 86) (:id . 56))\n ((:tag . "NN") (:stem . "up-regulation") (:form . "up-regulation")\n  (:end . 115) (:start . 102) (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 117) (:start . 116)\n  (:id . 58))\n ((:tag . "NN") (:stem . "hypertranscription") (:form . "hypertranscription")\n  (:end . 135) (:start . 117) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 136) (:start . 135)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 139) (:start . 137)\n  (:id . 61))\n ((:tag . "RB") (:stem . "essentially") (:form . "essentially") (:end . 151)\n  (:start . 140) (:id . 62))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 155) (:start . 152)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 161)\n  (:start . 156) (:id . 64))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 164) (:start . 162)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 168) (:start . 165)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 175)\n  (:start . 169) (:id . 67))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 177) (:start . 176)\n  (:id . 68))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 188)\n  (:start . 178) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:identifiers (:sid . :s9.11) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102584@unknown@formal@none@1@S@In C. elegans and Drosophila, several proteins with different molecular functions involved in dosage compensation have been identified.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 5) (:start . 3)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 13)\n  (:start . 6) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 51) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 61)\n  (:start . 52) (:id . 51))\n ((:tag . "JJ") (:stem . "molecular") (:form . "molecular") (:end . 71)\n  (:start . 62) (:id . 52))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 81)\n  (:start . 72) (:id . 53))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 90)\n  (:start . 82) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 55))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 100)\n  (:start . 94) (:id . 56))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 113)\n  (:start . 101) (:id . 57))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 118) (:start . 114)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 123) (:start . 119)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "identify") (:form . "identified") (:end . 134)\n  (:start . 124) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s9.12) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102585@unknown@formal@none@1@S@Much attention has been dedicated to the elusive question of how the compensated or inactivated chromosomes are recognized by these proteins, and three recent papers investigating some of these aspects in Drosophila have provided new insights into this mystery [1,2,3].@(((:tag . "JJ") (:stem . "much") (:form . "Much") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "attention") (:form . "attention") (:end . 14)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 18) (:start . 15)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "VBN") (:stem . "dedicate") (:form . "dedicated") (:end . 33)\n  (:start . 24) (:id . 46))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 36) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "elusive") (:form . "elusive") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 57)\n  (:start . 49) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 60) (:start . 58)\n  (:id . 51))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 64) (:start . 61)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "compensate") (:form . "compensated") (:end . 80)\n  (:start . 69) (:id . 54))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 83) (:start . 81)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "inactivate") (:form . "inactivated") (:end . 95)\n  (:start . 84) (:id . 56))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 107)\n  (:start . 96) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 111) (:start . 108)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 122)\n  (:start . 112) (:id . 59))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 125) (:start . 123)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 131)\n  (:start . 126) (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 140)\n  (:start . 132) (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 141) (:start . 140)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 145) (:start . 142)\n  (:id . 64))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 151)\n  (:start . 146) (:id . 65))\n ((:tag . "JJ") (:stem . "recent") (:form . "recent") (:end . 158)\n  (:start . 152) (:id . 66))\n ((:tag . "NNS") (:stem . "paper") (:form . "papers") (:end . 165)\n  (:start . 159) (:id . 67))\n ((:tag . "VBG") (:stem . "investigate") (:form . "investigating")\n  (:end . 179) (:start . 166) (:id . 68))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 184) (:start . 180)\n  (:id . 69))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 187) (:start . 185)\n  (:id . 70))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 193)\n  (:start . 188) (:id . 71))\n ((:tag . "NNS") (:stem . "aspect") (:form . "aspects") (:end . 201)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 204) (:start . 202)\n  (:id . 73))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 215)\n  (:start . 205) (:id . 74))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 220) (:start . 216)\n  (:id . 75))\n ((:tag . "VBN") (:stem . "provide") (:form . "provided") (:end . 229)\n  (:start . 221) (:id . 76))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 233) (:start . 230)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "insight") (:form . "insights") (:end . 242)\n  (:start . 234) (:id . 78))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 247) (:start . 243)\n  (:id . 79))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 252) (:start . 248)\n  (:id . 80))\n ((:tag . "NN") (:stem . "mystery") (:form . "mystery") (:end . 260)\n  (:start . 253) (:id . 81))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 262) (:start . 261)\n  (:id . 82))\n ((:tag . "CD") (:stem . "1,2,3") (:form . "1,2,3") (:end . 267)\n  (:start . 262) (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 268) (:start . 267)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 269) (:start . 268)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s9.13) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102586@unknown@formal@none@1@S@At least one common theme has emerged in Drosophila and mammals of how the dosage-compensated chromosomes are marked and eventually recognized by regulatory proteins: the use of non-coding RNAs transcribed from genes located on the X chromosome itself [4,5,6,7].@(((:tag . "IN") (:stem . "at") (:form . "At") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 8) (:start . 3)\n  (:id . 43))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "common") (:form . "common") (:end . 19)\n  (:start . 13) (:id . 45))\n ((:tag . "NN") (:stem . "theme") (:form . "theme") (:end . 25) (:start . 20)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 29) (:start . 26)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "emerge") (:form . "emerged") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 40) (:start . 38)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 51)\n  (:start . 41) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 55) (:start . 52)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "dosage-compensated") (:form . "dosage-compensated")\n  (:end . 93) (:start . 75) (:id . 56))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 105)\n  (:start . 94) (:id . 57))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 109) (:start . 106)\n  (:id . 58))\n ((:tag . "JJ") (:stem . "marked") (:form . "marked") (:end . 116)\n  (:start . 110) (:id . 59))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 60))\n ((:tag . "RB") (:stem . "eventually") (:form . "eventually") (:end . 131)\n  (:start . 121) (:id . 61))\n ((:tag . "VBN") (:stem . "recognize") (:form . "recognized") (:end . 142)\n  (:start . 132) (:id . 62))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 145) (:start . 143)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "regulatory") (:form . "regulatory") (:end . 156)\n  (:start . 146) (:id . 64))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 165)\n  (:start . 157) (:id . 65))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 166) (:start . 165)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 170) (:start . 167)\n  (:id . 67))\n ((:tag . "NN") (:stem . "use") (:form . "use") (:end . 174) (:start . 171)\n  (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 177) (:start . 175)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "non-coding") (:form . "non-coding") (:end . 188)\n  (:start . 178) (:id . 70))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 193) (:start . 189)\n  (:id . 71))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 205)\n  (:start . 194) (:id . 72))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 210) (:start . 206)\n  (:id . 73))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 216)\n  (:start . 211) (:id . 74))\n ((:tag . "VBN") (:stem . "locate") (:form . "located") (:end . 224)\n  (:start . 217) (:id . 75))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 227) (:start . 225)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 231) (:start . 228)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 233) (:start . 232)\n  (:id . 78))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 244)\n  (:start . 234) (:id . 79))\n ((:tag . "PRP") (:stem . "itself") (:form . "itself") (:end . 251)\n  (:start . 245) (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 253) (:start . 252)\n  (:id . 81))\n ((:tag . "CD") (:stem . "4,5,6,7") (:form . "4,5,6,7") (:end . 260)\n  (:start . 253) (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 261) (:start . 260)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 262) (:start . 261)\n  (:id . 84)))@@@1@43@((:identifiers (:sid . :s9.14) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102587@unknown@formal@none@1@S@These RNAs, Xist (X-inactive specific transcript) in mammals, and roX1 and roX2 (RNA on the X) in Drosophila, are structurally unrelated, yet they share the intriguing property of remaining tightly associated with the X chromosome.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 10) (:start . 6)\n  (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Xist") (:form . "Xist") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 18) (:start . 17)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "x-inactive") (:form . "X-inactive") (:end . 28)\n  (:start . 18) (:id . 47))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 37)\n  (:start . 29) (:id . 48))\n ((:tag . "NN") (:stem . "transcript") (:form . "transcript") (:end . 48)\n  (:start . 38) (:id . 49))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 52) (:start . 50)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 65) (:start . 62)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 70) (:start . 66)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 74) (:start . 71)\n  (:id . 56))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 79) (:start . 75)\n  (:id . 57))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 81) (:start . 80)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 84) (:start . 81)\n  (:id . 59))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 87) (:start . 85)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 93) (:start . 92)\n  (:id . 62))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 94) (:start . 93)\n  (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 97) (:start . 95)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 108)\n  (:start . 98) (:id . 65))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 109) (:start . 108)\n  (:id . 66))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 113) (:start . 110)\n  (:id . 67))\n ((:tag . "RB") (:stem . "structurally") (:form . "structurally") (:end . 126)\n  (:start . 114) (:id . 68))\n ((:tag . "JJ") (:stem . "unrelated") (:form . "unrelated") (:end . 136)\n  (:start . 127) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 137) (:start . 136)\n  (:id . 70))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 141) (:start . 138)\n  (:id . 71))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 146) (:start . 142)\n  (:id . 72))\n ((:tag . "VBP") (:stem . "share") (:form . "share") (:end . 152)\n  (:start . 147) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 156) (:start . 153)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "intriguing") (:form . "intriguing") (:end . 167)\n  (:start . 157) (:id . 75))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 176)\n  (:start . 168) (:id . 76))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 179) (:start . 177)\n  (:id . 77))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 189)\n  (:start . 180) (:id . 78))\n ((:tag . "RB") (:stem . "tightly") (:form . "tightly") (:end . 197)\n  (:start . 190) (:id . 79))\n ((:tag . "VBN") (:stem . "associate") (:form . "associated") (:end . 208)\n  (:start . 198) (:id . 80))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 213) (:start . 209)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 217) (:start . 214)\n  (:id . 82))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 219) (:start . 218)\n  (:id . 83))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 230)\n  (:start . 220) (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 231) (:start . 230)\n  (:id . 85)))@@@1@44@((:identifiers (:sid . :s9.15) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102588@unknown@formal@none@1@S@In mammals, Xist RNA is transcribed only from the inactive X, with which it associates at its site of synthesis and then spreads over the entire chromosome through an unknown mechanism [8].@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "mammal") (:form . "mammals") (:end . 10)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 11) (:start . 10)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "Xist") (:form . "Xist") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "transcribe") (:form . "transcribed") (:end . 35)\n  (:start . 24) (:id . 48))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 40) (:start . 36)\n  (:id . 49))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 45) (:start . 41)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "inactive") (:form . "inactive") (:end . 58)\n  (:start . 50) (:id . 52))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 54))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 72) (:start . 67)\n  (:id . 56))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 75) (:start . 73)\n  (:id . 57))\n ((:tag . "VBZ") (:stem . "associate") (:form . "associates") (:end . 86)\n  (:start . 76) (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 89) (:start . 87)\n  (:id . 59))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 93) (:start . 90)\n  (:id . 60))\n ((:tag . "NN") (:stem . "site") (:form . "site") (:end . 98) (:start . 94)\n  (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 101) (:start . 99)\n  (:id . 62))\n ((:tag . "NN") (:stem . "synthesis") (:form . "synthesis") (:end . 111)\n  (:start . 102) (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 115) (:start . 112)\n  (:id . 64))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 120) (:start . 116)\n  (:id . 65))\n ((:tag . "VBZ") (:stem . "spread") (:form . "spreads") (:end . 128)\n  (:start . 121) (:id . 66))\n ((:tag . "IN") (:stem . "over") (:form . "over") (:end . 133) (:start . 129)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 144)\n  (:start . 138) (:id . 69))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 155)\n  (:start . 145) (:id . 70))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 163)\n  (:start . 156) (:id . 71))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 166) (:start . 164)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 174)\n  (:start . 167) (:id . 73))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 184)\n  (:start . 175) (:id . 74))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 186) (:start . 185)\n  (:id . 75))\n ((:tag . "CD") (:stem . "8") (:form . "8") (:end . 187) (:start . 186)\n  (:id . 76))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 188) (:start . 187)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 78)))@@@1@37@((:identifiers (:sid . :s9.16) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102590@unknown@formal@none@1@S@The Drosophila dosage compensation complex@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 21)\n  (:start . 15) (:id . 44))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 34)\n  (:start . 22) (:id . 45))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 42)\n  (:start . 35) (:id . 46)))@@@1@5@((:identifiers (:sid . :s9.18) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|SectionTitle|)))@oe@9-2-2011
5102591@unknown@formal@none@1@S@In Drosophila, the dosage compensation complex (DCC) is composed of five proteins encoded by the male-specific lethal genes, male-specific lethal-1, -2, -3 (msl1, msl2 and msl3), maleless (mle) and males absent on the first (mof), and at least two non-coding RNAs, roX1 and roX2 (for a review see [12]).@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 13)\n  (:start . 3) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 25)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 38)\n  (:start . 26) (:id . 47))\n ((:tag . "NN") (:stem . "complex") (:form . 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",") (:stem . ",") (:form . ",") (:end . 230) (:start . 229)\n  (:id . 91))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 234) (:start . 231)\n  (:id . 92))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 237) (:start . 235)\n  (:id . 93))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 243)\n  (:start . 238) (:id . 94))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 247) (:start . 244)\n  (:id . 95))\n ((:tag . "JJ") (:stem . "non-coding") (:form . "non-coding") (:end . 258)\n  (:start . 248) (:id . 96))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 263) (:start . 259)\n  (:id . 97))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 264) (:start . 263)\n  (:id . 98))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 269) (:start . 265)\n  (:id . 99))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 273) (:start . 270)\n  (:id . 100))\n ((:tag . "NN") (:stem . "rox2") (:form . 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(:end . 303) (:start . 302)\n  (:id . 111)))@@@1@70@((:identifiers (:sid . :s9.19) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102592@unknown@formal@none@1@S@The MSL proteins colocalize to hundreds of sites along the single male X chromosome; they all are essential for the hypertranscription of the X-chromosomal genes in males, as male but not female animals die during development when they are mutant for any one of the five msl genes.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 16)\n  (:start . 8) (:id . 44))\n ((:tag . "VBP") (:stem . "colocalize") (:form . "colocalize") (:end . 27)\n  (:start . 17) (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "hundred") (:form . "hundreds") (:end . 39)\n  (:start . 31) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . 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5102593@unknown@formal@none@1@S@Hypertranscription is a consequence of at least one chromatin modification: the acetylation of histone H4 at Lys16, which is thought to ''loosen'' chromatin structure, thereby allowing the general transcription machinery easier access to the regulatory regions of most X-linked genes [13].@(((:tag . "NNP") (:stem . "Hypertranscription") (:form . "Hypertranscription")\n  (:end . 18) (:start . 0) (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 23) (:start . 22)\n  (:id . 44))\n ((:tag . "NN") (:stem . "consequence") (:form . "consequence") (:end . 35)\n  (:start . 24) (:id . 45))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 46))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 41) (:start . 39)\n  (:id . 47))\n ((:tag . "JJS") (:stem . "least") (:form . 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5102594@unknown@formal@none@1@S@The role of the roX genes and roX RNAs in this process is still unclear.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 15) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 19) (:start . 16)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 25) (:start . 20)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 29) (:start . 26)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 33) (:start . 30)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 38) (:start . 34)\n  (:id . 50))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 41) (:start . 39)\n  (:id . 51))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 46) (:start . 42)\n  (:id . 52))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 57) (:start . 55)\n  (:id . 54))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 63) (:start . 58)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 71)\n  (:start . 64) (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 72) (:start . 71)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x9.22.1) (:span 64 71)))\n (:hscopes ((:id . :x9.22.1) (:span 0 71)))\n (:identifiers (:sid . :s9.22) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102595@unknown@formal@none@1@S@Localization studies of MSL proteins in male nuclei carrying autosomal roX1 or roX2 transgenes showed that the roX genes or RNAs recruit the entire set of MSL proteins to their transgenic location and can lead locally to acetylation of histone H4 [1,14].@(((:tag . "NNP") (:stem . "Localization") (:form . "Localization") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 20)\n  (:start . 13) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 44))\n ((:tag . "NN") (:stem . "msl") (:form . "MSL") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 36)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 39) (:start . 37)\n  (:id . 47))\n ((:tag . "JJ") (:stem . "male") (:form . "male") (:end . 44) (:start . 40)\n  (:id . 48))\n ((:tag . "NNS") (:stem . "nucleus") (:form . "nuclei") (:end . 51)\n  (:start . 45) (:id . 49))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 60)\n  (:start . 52) (:id . 50))\n ((:tag . "JJ") (:stem . "autosomal") (:form . "autosomal") (:end . 70)\n  (:start . 61) (:id . 51))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 75) (:start . 71)\n  (:id . 52))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 78) (:start . 76)\n  (:id . 53))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 83) (:start . 79)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "transgene") (:form . "transgenes") (:end . 94)\n  (:start . 84) (:id . 55))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 101)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 106) (:start . 102)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 120)\n  (:start . 115) (:id . 60))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 123) (:start . 121)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 128) (:start . 124)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "recruit") (:form . "recruit") (:end . 136)\n  (:start . 129) (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 140) (:start . 137)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 147)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "set") (:form . "set") (:end . 151) (:start . 148)\n  (:id . 66))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 154) (:start . 152)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 158) (:start . 155)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 167)\n  (:start . 159) (:id . 69))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 170) (:start . 168)\n  (:id . 70))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 176)\n  (:start . 171) (:id . 71))\n ((:tag . "JJ") (:stem . "transgenic") (:form . "transgenic") (:end . 187)\n  (:start . 177) (:id . 72))\n ((:tag . "NN") (:stem . "location") (:form . "location") (:end . 196)\n  (:start . 188) (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 200) (:start . 197)\n  (:id . 74))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 204) (:start . 201)\n  (:id . 75))\n ((:tag . "VB") (:stem . "lead") (:form . "lead") (:end . 209) (:start . 205)\n  (:id . 76))\n ((:tag . "RB") (:stem . "locally") (:form . "locally") (:end . 217)\n  (:start . 210) (:id . 77))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 220) (:start . 218)\n  (:id . 78))\n ((:tag . "NN") (:stem . "acetylation") (:form . "acetylation") (:end . 232)\n  (:start . 221) (:id . 79))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 235) (:start . 233)\n  (:id . 80))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 243)\n  (:start . 236) (:id . 81))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 246) (:start . 244)\n  (:id . 82))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 248) (:start . 247)\n  (:id . 83))\n ((:tag . "CD") (:stem . "1,14") (:form . "1,14") (:end . 252) (:start . 248)\n  (:id . 84))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 253) (:start . 252)\n  (:id . 85))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 254) (:start . 253)\n  (:id . 86)))@@@1@45@((:hcues ((:id . :x9.23.1) (:span 201 204))\n  ((:id . :x9.23.2) (:span 121 123)))\n (:hscopes ((:id . :x9.23.1) (:span 201 246))\n  ((:id . :x9.23.2) (:span 107 128)))\n (:identifiers (:sid . :s9.23) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102596@unknown@formal@none@1@S@Moreover, the DCCs can spread, by several hundred kilobases, into neighboring autosomal DNA.@(((:tag . "RB") (:stem . "moreover") (:form . "Moreover") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 9) (:start . 8) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "NNPS") (:stem . "DCC") (:form . "DCCs") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "VB") (:stem . "spread") (:form . "spread") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 33) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 41)\n  (:start . 34) (:id . 50))\n ((:tag . "CD") (:stem . "hundred") (:form . "hundred") (:end . 49)\n  (:start . 42) (:id . 51))\n ((:tag . "NNS") (:stem . "kilobas") (:form . "kilobases") (:end . 59)\n  (:start . 50) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 60) (:start . 59)\n  (:id . 53))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 65) (:start . 61)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 77)\n  (:start . 66) (:id . 55))\n ((:tag . "JJ") (:stem . "autosomal") (:form . "autosomal") (:end . 87)\n  (:start . 78) (:id . 56))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 92) (:start . 91)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s9.24) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102597@unknown@formal@none@1@S@These experiments indicated that the roX genes might function as nuclear entry sites for the assembly of the MSL proteins on the X chromosome.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 17)\n  (:start . 6) (:id . 43))\n ((:tag . "VBD") (:stem . "indicate") (:form . "indicated") (:end . 27)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 40) (:start . 37)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 46) (:start . 41)\n  (:id . 48))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 52) (:start . 47)\n  (:id . 49))\n ((:tag . "VB") (:stem . "function") (:form . "function") (:end . 61)\n  (:start . 53) (:id . 50))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 64) (:start . 62)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "nuclear") (:form . "nuclear") (:end . 72)\n  (:start . 65) (:id . 52))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 78) (:start . 73)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 84) (:start . 79)\n  (:id . 54))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 88) (:start . 85)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 92) (:start . 89)\n  (:id . 56))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 101)\n  (:start . 93) (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 104) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 108) (:start . 105)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 112) (:start . 109)\n  (:id . 60))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 121)\n  (:start . 113) (:id . 61))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 124) (:start . 122)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 128) (:start . 125)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 130) (:start . 129)\n  (:id . 64))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 141)\n  (:start . 131) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 142) (:start . 141)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x9.25.1) (:span 47 52)) ((:id . :x9.25.2) (:span 18 32)))\n (:hscopes ((:id . :x9.25.1) (:span 47 141))\n  ((:id . :x9.25.2) (:span 18 141)))\n (:identifiers (:sid . :s9.25) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102598@unknown@formal@none@1@S@Little was known, however, about the specific role of the roX RNAs during the formation of the DCC.@(((:tag . "NNP") (:stem . "Little") (:form . "Little") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 10) (:start . 7)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 25)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 26) (:start . 25)\n  (:id . 47))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 32) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 45)\n  (:start . 37) (:id . 50))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 50) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 53) (:start . 51)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 66) (:start . 62)\n  (:id . 55))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 73)\n  (:start . 67) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 87)\n  (:start . 78) (:id . 58))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 98) (:start . 95)\n  (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s9.26) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102600@unknown@formal@none@1@S@Meller et al. [1] took advantage of the fact that dosage compensation can be initiated and analyzed in females ectopically expressing the male-specific MSL2 protein.@(((:tag . "NNP") (:stem . "Meller") (:form . "Meller") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "take") (:form . "took") (:end . 22) (:start . 18)\n  (:id . 48))\n ((:tag . "NN") (:stem . "advantage") (:form . "advantage") (:end . 32)\n  (:start . 23) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 35) (:start . 33)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 44) (:start . 40)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 49) (:start . 45)\n  (:id . 53))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 56)\n  (:start . 50) (:id . 54))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 69)\n  (:start . 57) (:id . 55))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 73) (:start . 70)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 76) (:start . 74)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "initiate") (:form . "initiated") (:end . 86)\n  (:start . 77) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 90) (:start . 87)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 99)\n  (:start . 91) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 102) (:start . 100)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 110)\n  (:start . 103) (:id . 62))\n ((:tag . "RB") (:stem . "ectopically") (:form . "ectopically") (:end . 122)\n  (:start . 111) (:id . 63))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 133)\n  (:start . 123) (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "male-specific") (:form . "male-specific")\n  (:end . 151) (:start . 138) (:id . 66))\n ((:tag . "NN") (:stem . "msl2") (:form . "MSL2") (:end . 156) (:start . 152)\n  (:id . 67))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 164)\n  (:start . 157) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 165) (:start . 164)\n  (:id . 69)))@@@1@28@((:identifiers (:sid . :s9.28) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102601@unknown@formal@none@1@S@These females hypertranscribe their two X chromosomes and therefore die during development, but they can be rescued if any other msl mutation is present.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 13)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "hypertranscribe") (:form . "hypertranscribe")\n  (:end . 29) (:start . 14) (:id . 44))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 35)\n  (:start . 30) (:id . 45))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 39) (:start . 36)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 41) (:start . 40)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 53)\n  (:start . 42) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "VBP") (:stem . "die") (:form . "die") (:end . 71) (:start . 68)\n  (:id . 51))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 78)\n  (:start . 72) (:id . 52))\n ((:tag . "NN") (:stem . "development") (:form . "development") (:end . 90)\n  (:start . 79) (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 91) (:start . 90)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 95) (:start . 92)\n  (:id . 55))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 100) (:start . 96)\n  (:id . 56))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 104) (:start . 101)\n  (:id . 57))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 107) (:start . 105)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "rescue") (:form . "rescued") (:end . 115)\n  (:start . 108) (:id . 59))\n ((:tag . "IN") (:stem . "if") (:form . "if") (:end . 118) (:start . 116)\n  (:id . 60))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 122) (:start . 119)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 128)\n  (:start . 123) (:id . 62))\n ((:tag . "NN") (:stem . "msl") (:form . "msl") (:end . 132) (:start . 129)\n  (:id . 63))\n ((:tag . "NN") (:stem . "mutation") (:form . "mutation") (:end . 141)\n  (:start . 133) (:id . 64))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 144) (:start . 142)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 152)\n  (:start . 145) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 153) (:start . 152)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s9.29) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102602@unknown@formal@none@1@S@It has been shown previously, using a similar strategy, that the DCC is assembled in an ordered sequence (Figure 1).@(((:tag . "PRP") (:stem . "it") (:form . "It") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "have") (:form . "has") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "show") (:form . "shown") (:end . 17) (:start . 12)\n  (:id . 45))\n ((:tag . "RB") (:stem . "previously") (:form . "previously") (:end . 28)\n  (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 35) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "similar") (:form . "similar") (:end . 45)\n  (:start . 38) (:id . 50))\n ((:tag . "NN") (:stem . "strategy") (:form . "strategy") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 55) (:start . 54)\n  (:id . 52))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 60) (:start . 56)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 68) (:start . 65)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 71) (:start . 69)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "assemble") (:form . "assembled") (:end . 81)\n  (:start . 72) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 84) (:start . 82)\n  (:id . 58))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 87) (:start . 85)\n  (:id . 59))\n ((:tag . "VBN") (:stem . "order") (:form . "ordered") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "NN") (:stem . "sequence") (:form . "sequence") (:end . 104)\n  (:start . 96) (:id . 61))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 106) (:start . 105)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 112)\n  (:start . 106) (:id . 63))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 114) (:start . 113)\n  (:id . 64))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 115) (:start . 114)\n  (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 66)))@@@1@25@((:identifiers (:sid . :s9.30) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102603@unknown@formal@none@1@S@For example, MSL1 and MSL2 are the first proteins to bind to the X chromosome; in the absence of all other MSL proteins they associate with about 35 sites, the so-called chromatin entry sites.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MSL1") (:form . "MSL1") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "MSL2") (:form . "MSL2") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 40) (:start . 35)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 49)\n  (:start . 41) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 60) (:start . 58)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 64) (:start . 61)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 66) (:start . 65)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 77)\n  (:start . 67) (:id . 57))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 78) (:start . 77)\n  (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 81) (:start . 79)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 85) (:start . 82)\n  (:id . 60))\n ((:tag . "NN") (:stem . "absence") (:form . "absence") (:end . 93)\n  (:start . 86) (:id . 61))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 96) (:start . 94)\n  (:id . 62))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 100) (:start . 97)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 106)\n  (:start . 101) (:id . 64))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 110) (:start . 107)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 66))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 124) (:start . 120)\n  (:id . 67))\n ((:tag . "VBP") (:stem . "associate") (:form . "associate") (:end . 134)\n  (:start . 125) (:id . 68))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 139) (:start . 135)\n  (:id . 69))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 145)\n  (:start . 140) (:id . 70))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 148) (:start . 146)\n  (:id . 71))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 154)\n  (:start . 149) (:id . 72))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 155) (:start . 154)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 159) (:start . 156)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "so-called") (:form . "so-called") (:end . 169)\n  (:start . 160) (:id . 75))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 179)\n  (:start . 170) (:id . 76))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 185)\n  (:start . 180) (:id . 77))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 191)\n  (:start . 186) (:id . 78))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 192) (:start . 191)\n  (:id . 79)))@@@1@38@((:identifiers (:sid . :s9.31) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102604@unknown@formal@none@1@S@MSL1 and MSL2 are interdependent, however: they require each other for binding [15].@(((:tag . "NNP") (:stem . "MSL1") (:form . "MSL1") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "MSL2") (:form . "MSL2") (:end . 13) (:start . 9)\n  (:id . 44))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "interdependent") (:form . "interdependent")\n  (:end . 32) (:start . 18) (:id . 46))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 33) (:start . 32)\n  (:id . 47))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 41)\n  (:start . 34) (:id . 48))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 42) (:start . 41)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 60) (:start . 56)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 70) (:start . 67)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 78)\n  (:start . 71) (:id . 55))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 80) (:start . 79)\n  (:id . 56))\n ((:tag . "CD") (:stem . "15") (:form . "15") (:end . 82) (:start . 80)\n  (:id . 57))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s9.32) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102605@unknown@formal@none@1@S@MLE appears to be the next protein to join the growing DCC as it is found at reduced levels at some of these 35 sites when the remaining two proteins, MSL3 and MOF, are absent [16].@(((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 26) (:start . 22)\n  (:id . 47))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 34)\n  (:start . 27) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 49))\n ((:tag . "VB") (:stem . "join") (:form . "join") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "grow") (:form . "growing") (:end . 54)\n  (:start . 47) (:id . 52))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 64) (:start . 62)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 67) (:start . 65)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 73) (:start . 68)\n  (:id . 57))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 76) (:start . 74)\n  (:id . 58))\n ((:tag . "VBN") (:stem . "reduce") (:form . "reduced") (:end . 84)\n  (:start . 77) (:id . 59))\n ((:tag . "NNS") (:stem . "level") (:form . "levels") (:end . 91)\n  (:start . 85) (:id . 60))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 94) (:start . 92)\n  (:id . 61))\n ((:tag . "DT") (:stem . "some") (:form . "some") (:end . 99) (:start . 95)\n  (:id . 62))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 102) (:start . 100)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 108)\n  (:start . 103) (:id . 64))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 111) (:start . 109)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 117)\n  (:start . 112) (:id . 66))\n ((:tag . "WRB") (:stem . "when") (:form . "when") (:end . 122) (:start . 118)\n  (:id . 67))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 68))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 136)\n  (:start . 127) (:id . 69))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 140) (:start . 137)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 149)\n  (:start . 141) (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 150) (:start . 149)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 155) (:start . 151)\n  (:id . 73))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 159) (:start . 156)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 163) (:start . 160)\n  (:id . 75))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 76))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 168) (:start . 165)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 175)\n  (:start . 169) (:id . 78))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 177) (:start . 176)\n  (:id . 79))\n ((:tag . "CD") (:stem . "16") (:form . "16") (:end . 179) (:start . 177)\n  (:id . 80))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 180) (:start . 179)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 181) (:start . 180)\n  (:id . 82)))@@@1@41@((:hcues ((:id . :x9.33.1) (:span 4 11)))\n (:hscopes ((:id . :x9.33.1) (:span 0 58)))\n (:identifiers (:sid . :s9.33) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102606@unknown@formal@none@1@S@These latter two proteins require all the other MSL proteins to be present to enable them to associate with the X chromosome.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "latter") (:form . "latter") (:end . 12) (:start . 6)\n  (:id . 43))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 25)\n  (:start . 17) (:id . 45))\n ((:tag . "VBP") (:stem . "require") (:form . "require") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 41) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 47) (:start . 42)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 51) (:start . 48)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 60)\n  (:start . 52) (:id . 51))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 74)\n  (:start . 67) (:id . 54))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 55))\n ((:tag . "VB") (:stem . "enable") (:form . "enable") (:end . 84)\n  (:start . 78) (:id . 56))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 89) (:start . 85)\n  (:id . 57))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 92) (:start . 90)\n  (:id . 58))\n ((:tag . "VB") (:stem . "associate") (:form . "associate") (:end . 102)\n  (:start . 93) (:id . 59))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 107) (:start . 103)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 111) (:start . 108)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 113) (:start . 112)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 124)\n  (:start . 114) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 125) (:start . 124)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s9.34) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102607@unknown@formal@none@1@S@Importantly, all MSLs are required to generate the normal DCC distribution to the hundreds of sites throughout the entire X chromosome.@(((:tag . "RB") (:stem . "importantly") (:form . "Importantly") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "NNPS") (:stem . "MSL") (:form . "MSLs") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 25) (:start . 22)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "require") (:form . "required") (:end . 34)\n  (:start . 26) (:id . 47))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "VB") (:stem . "generate") (:form . "generate") (:end . 46)\n  (:start . 38) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "normal") (:form . "normal") (:end . 57)\n  (:start . 51) (:id . 51))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 74)\n  (:start . 62) (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 77) (:start . 75)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 81) (:start . 78)\n  (:id . 55))\n ((:tag . "NNS") (:stem . "hundred") (:form . "hundreds") (:end . 90)\n  (:start . 82) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 99) (:start . 94)\n  (:id . 58))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 60))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 121)\n  (:start . 115) (:id . 61))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 123) (:start . 122)\n  (:id . 62))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 134)\n  (:start . 124) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s9.35) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102608@unknown@formal@none@1@S@Meller et al. [1] have now analyzed and compared roX RNA and MSL protein distribution in females ectopically expressing MSL2 but lacking other MSL proteins.@(((:tag . "NNP") (:stem . "Meller") (:form . "Meller") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 22) (:start . 18)\n  (:id . 48))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 26) (:start . 23)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "analyze") (:form . "analyzed") (:end . 35)\n  (:start . 27) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 39) (:start . 36)\n  (:id . 51))\n ((:tag . "VBN") (:stem . "compare") (:form . "compared") (:end . 48)\n  (:start . 40) (:id . 52))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 56) (:start . 53)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 64) (:start . 61)\n  (:id . 56))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 72)\n  (:start . 65) (:id . 57))\n ((:tag . "NN") (:stem . "distribution") (:form . "distribution") (:end . 85)\n  (:start . 73) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . "RB") (:stem . "ectopically") (:form . "ectopically") (:end . 108)\n  (:start . 97) (:id . 61))\n ((:tag . "VBG") (:stem . "express") (:form . "expressing") (:end . 119)\n  (:start . 109) (:id . 62))\n ((:tag . "NN") (:stem . "msl2") (:form . "MSL2") (:end . 124) (:start . 120)\n  (:id . 63))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 128) (:start . 125)\n  (:id . 64))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 136)\n  (:start . 129) (:id . 65))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 142)\n  (:start . 137) (:id . 66))\n ((:tag . "NN") (:stem . "msl") (:form . "MSL") (:end . 146) (:start . 143)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 155)\n  (:start . 147) (:id . 68))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 156) (:start . 155)\n  (:id . 69)))@@@1@28@((:ncues ((:id . :x9.36.1) (:span 129 136)))\n (:nscopes ((:id . :x9.36.1) (:span 129 155)))\n (:identifiers (:sid . :s9.36) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102610@unknown@formal@none@1@S@When the MLE protein, which encodes an RNA helicase, was absent, both roX RNAs were found only at their site of transcription but not in any other of the 35 entry sites where MSL1 and MSL2 were present, suggesting that neither of the roX RNAs can be integrated in a minimal MSL1-MSL2 complex.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 8) (:start . 5)\n  (:id . 43))\n ((:tag . "NN") (:stem . "mle") (:form . "MLE") (:end . 12) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 21) (:start . 20)\n  (:id . 46))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 27) (:start . 22)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 35)\n  (:start . 28) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 38) (:start . 36)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "helicase") (:form . "helicase") (:end . 51)\n  (:start . 43) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 63)\n  (:start . 57) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 64) (:start . 63)\n  (:id . 55))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 69) (:start . 65)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 78) (:start . 74)\n  (:id . 58))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 83) (:start . 79)\n  (:id . 59))\n ((:tag . 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"VBD") (:stem . "be") (:form . "were") (:end . 193) (:start . 189)\n  (:id . 81))\n ((:tag . "JJ") (:stem . "present") (:form . "present") (:end . 201)\n  (:start . 194) (:id . 82))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 202) (:start . 201)\n  (:id . 83))\n ((:tag . "VBG") (:stem . "suggest") (:form . "suggesting") (:end . 213)\n  (:start . 203) (:id . 84))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 218) (:start . 214)\n  (:id . 85))\n ((:tag . "DT") (:stem . "neither") (:form . "neither") (:end . 226)\n  (:start . 219) (:id . 86))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 229) (:start . 227)\n  (:id . 87))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 233) (:start . 230)\n  (:id . 88))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 237) (:start . 234)\n  (:id . 89))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 242) (:start . 238)\n  (:id . 90))\n ((:tag . "MD") (:stem . "can") (:form . 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(:end . 292) (:start . 291)\n  (:id . 99)))@@@1@58@((:hcues ((:id . :x9.38.2) (:span 203 213)))\n (:ncues ((:id . :x9.38.1) (:span 219 226))\n  ((:id . :x9.38.3) (:span 130 133)))\n (:hscopes ((:id . :x9.38.2) (:span 203 291)))\n (:nscopes ((:id . :x9.38.1) (:span 219 291))\n  ((:id . :x9.38.3) (:span 130 201)))\n (:identifiers (:sid . :s9.38) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102611@unknown@formal@none@1@S@When MSL3 was absent in these females, however, roX2 but not roX1 RNA was found at the entry 35 sites.@(((:tag . "WRB") (:stem . "when") (:form . "When") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 9) (:start . 5)\n  (:id . 43))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "absent") (:form . "absent") (:end . 20)\n  (:start . 14) (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "female") (:form . "females") (:end . 37)\n  (:start . 30) (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 38) (:start . 37)\n  (:id . 49))\n ((:tag . "RB") (:stem . "however") (:form . "however") (:end . 46)\n  (:start . 39) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 52) (:start . 48)\n  (:id . 52))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 53))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 60) (:start . 57)\n  (:id . 54))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 65) (:start . 61)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 69) (:start . 66)\n  (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 73) (:start . 70)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "find") (:form . "found") (:end . 79) (:start . 74)\n  (:id . 58))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 82) (:start . 80)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 60))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 92) (:start . 87)\n  (:id . 61))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 95) (:start . 93)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 101) (:start . 96)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 102) (:start . 101)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x9.39.1) (:span 57 60)) ((:id . :x9.39.2) (:span 14 20)))\n (:nscopes ((:id . :x9.39.1) (:span 57 69)) ((:id . :x9.39.2) (:span 5 37)))\n (:identifiers (:sid . :s9.39) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102612@unknown@formal@none@1@S@These findings indicate that roX2 might be incorporated into this partial DCC complex in an MLE-dependent manner and that roX1 RNA is incorporated at a later stage, together with MSL3 and perhaps MOF.@(((:tag . "DT") (:stem . "these") (:form . "These") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 14)\n  (:start . 6) (:id . 43))\n ((:tag . "VBP") (:stem . "indicate") (:form . "indicate") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 28) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 33) (:start . 29)\n  (:id . 46))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 39) (:start . 34)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 42) (:start . 40)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "incorporate") (:form . "incorporated") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 60) (:start . 56)\n  (:id . 50))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 65) (:start . 61)\n  (:id . 51))\n ((:tag . "JJ") (:stem . "partial") (:form . "partial") (:end . 73)\n  (:start . 66) (:id . 52))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 77) (:start . 74)\n  (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 85)\n  (:start . 78) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 88) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 91) (:start . 89)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "mle-dependent") (:form . "MLE-dependent")\n  (:end . 105) (:start . 92) (:id . 57))\n ((:tag . "NN") (:stem . "manner") (:form . "manner") (:end . 112)\n  (:start . 106) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 116) (:start . 113)\n  (:id . 59))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 121) (:start . 117)\n  (:id . 60))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 126) (:start . 122)\n  (:id . 61))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 130) (:start . 127)\n  (:id . 62))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 133) (:start . 131)\n  (:id . 63))\n ((:tag . "VBN") (:stem . "incorporate") (:form . "incorporated") (:end . 146)\n  (:start . 134) (:id . 64))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 151) (:start . 150)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "later") (:form . "later") (:end . 157)\n  (:start . 152) (:id . 67))\n ((:tag . "NN") (:stem . "stage") (:form . "stage") (:end . 163)\n  (:start . 158) (:id . 68))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 164) (:start . 163)\n  (:id . 69))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 173)\n  (:start . 165) (:id . 70))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 178) (:start . 174)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 183) (:start . 179)\n  (:id . 72))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 187) (:start . 184)\n  (:id . 73))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 195)\n  (:start . 188) (:id . 74))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 199) (:start . 196)\n  (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 200) (:start . 199)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x9.40.1) (:span 188 195)) ((:id . :x9.40.2) (:span 34 39))\n  ((:id . :x9.40.3) (:span 15 28)))\n (:hscopes ((:id . :x9.40.1) (:span 188 199))\n  ((:id . :x9.40.2) (:span 29 112)) ((:id . :x9.40.3) (:span 15 199)))\n (:identifiers (:sid . :s9.40) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102613@unknown@formal@none@1@S@Further evidence that at least roX2 RNA is an integral part of the DCC comes from independent immunoprecipitation experiments from all three groups [1,2,3] using extracts from Drosophila S2 cells that express all the MSLs and roX2 RNA.@(((:tag . "JJ") (:stem . "further") (:form . "Further") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 24) (:start . 22)\n  (:id . 45))\n ((:tag . "JJS") (:stem . "least") (:form . "least") (:end . 30) (:start . 25)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 42) (:start . 40)\n  (:id . 49))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 45) (:start . 43)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "integral") (:form . "integral") (:end . 54)\n  (:start . 46) (:id . 51))\n ((:tag . "NN") (:stem . "part") (:form . "part") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 66) (:start . 63)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "come") (:form . "comes") (:end . 76) (:start . 71)\n  (:id . 56))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 81) (:start . 77)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "independent") (:form . "independent") (:end . 93)\n  (:start . 82) (:id . 58))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 113) (:start . 94) (:id . 59))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 125)\n  (:start . 114) (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 130) (:start . 126)\n  (:id . 61))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 134) (:start . 131)\n  (:id . 62))\n ((:tag . "CD") (:stem . "three") (:form . "three") (:end . 140)\n  (:start . 135) (:id . 63))\n ((:tag . "NNS") (:stem . "group") (:form . "groups") (:end . 147)\n  (:start . 141) (:id . 64))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 149) (:start . 148)\n  (:id . 65))\n ((:tag . "CD") (:stem . "1,2,3") (:form . "1,2,3") (:end . 154)\n  (:start . 149) (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 155) (:start . 154)\n  (:id . 67))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 161) (:start . 156)\n  (:id . 68))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 175) (:start . 171)\n  (:id . 70))\n ((:tag . "FW") (:stem . "drosophila") (:form . "Drosophila") (:end . 186)\n  (:start . 176) (:id . 71))\n ((:tag . "NNP") (:stem . "S2") (:form . "S2") (:end . 189) (:start . 187)\n  (:id . 72))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 195)\n  (:start . 190) (:id . 73))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 200) (:start . 196)\n  (:id . 74))\n ((:tag . "VBP") (:stem . "express") (:form . "express") (:end . 208)\n  (:start . 201) (:id . 75))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 212) (:start . 209)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 216) (:start . 213)\n  (:id . 77))\n ((:tag . "NNS") (:stem . "msl") (:form . "MSLs") (:end . 221) (:start . 217)\n  (:id . 78))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 225) (:start . 222)\n  (:id . 79))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 230) (:start . 226)\n  (:id . 80))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 234) (:start . 231)\n  (:id . 81))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 235) (:start . 234)\n  (:id . 82)))@@@1@41@((:identifiers (:sid . :s9.41) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102614@unknown@formal@none@1@S@Surprisingly, Akthar et al. [2] found that DCC lacking MLE but containing the remaining MSLs still precipitated roX2 RNA.@(((:tag . "RB") (:stem . "surprisingly") (:form . "Surprisingly") (:end . 12)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 13) (:start . 12)\n  (:id . 43))\n ((:tag . "NNP") (:stem . "Akthar") (:form . "Akthar") (:end . 20)\n  (:start . 14) (:id . 44))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 29) (:start . 28)\n  (:id . 47))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 31) (:start . 30)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 37) (:start . 32)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 46) (:start . 43)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "lack") (:form . "lacking") (:end . 54)\n  (:start . 47) (:id . 53))\n ((:tag . "NN") (:stem . "mle") (:form . "MLE") (:end . 58) (:start . 55)\n  (:id . 54))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 62) (:start . 59)\n  (:id . 55))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 73)\n  (:start . 63) (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 87)\n  (:start . 78) (:id . 58))\n ((:tag . "NNS") (:stem . "msl") (:form . "MSLs") (:end . 92) (:start . 88)\n  (:id . 59))\n ((:tag . "RB") (:stem . "still") (:form . "still") (:end . 98) (:start . 93)\n  (:id . 60))\n ((:tag . "VBD") (:stem . "precipitate") (:form . "precipitated") (:end . 111)\n  (:start . 99) (:id . 61))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 116) (:start . 112)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 120) (:start . 117)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 121) (:start . 120)\n  (:id . 64)))@@@1@23@((:ncues ((:id . :x9.42.1) (:span 47 54)))\n (:nscopes ((:id . :x9.42.1) (:span 47 58)))\n (:identifiers (:sid . :s9.42) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102615@unknown@formal@none@1@S@The ordered assembly data from Meller et al. [1] as well as the fact that MLE is the only protein in the DCC featuring a known RNA-binding domain pointed towards the RNA helicase MLE as the primary candidate for a partner for the roX2 RNA.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBN") (:stem . "order") (:form . "ordered") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 20)\n  (:start . 12) (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 25) (:start . 21)\n  (:id . 45))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 30) (:start . 26)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Meller") (:form . "Meller") (:end . 37)\n  (:start . 31) (:id . 47))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 46) (:start . 45)\n  (:id . 50))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 48) (:start . 47)\n  (:id . 52))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 56) (:start . 52)\n  (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 59) (:start . 57)\n  (:id . 55))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 63) (:start . 60)\n  (:id . 56))\n ((:tag . "NN") (:stem . "fact") (:form . "fact") (:end . 68) (:start . 64)\n  (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 77) (:start . 74)\n  (:id . 59))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 80) (:start . 78)\n  (:id . 60))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 84) (:start . 81)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "only") (:form . "only") (:end . 89) (:start . 85)\n  (:id . 62))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 97)\n  (:start . 90) (:id . 63))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 100) (:start . 98)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 108) (:start . 105)\n  (:id . 66))\n ((:tag . "VBG") (:stem . "feature") (:form . "featuring") (:end . 118)\n  (:start . 109) (:id . 67))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 120) (:start . 119)\n  (:id . 68))\n ((:tag . "JJ") (:stem . "known") (:form . "known") (:end . 126)\n  (:start . 121) (:id . 69))\n ((:tag . "JJ") (:stem . "rna-binding") (:form . "RNA-binding") (:end . 138)\n  (:start . 127) (:id . 70))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 145)\n  (:start . 139) (:id . 71))\n ((:tag . "VBD") (:stem . "point") (:form . "pointed") (:end . 153)\n  (:start . 146) (:id . 72))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 161)\n  (:start . 154) (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 74))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 169) (:start . 166)\n  (:id . 75))\n ((:tag . "NN") (:stem . "helicase") (:form . "helicase") (:end . 178)\n  (:start . 170) (:id . 76))\n ((:tag . "NN") (:stem . "mle") (:form . "MLE") (:end . 182) (:start . 179)\n  (:id . 77))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 185) (:start . 183)\n  (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 189) (:start . 186)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 197)\n  (:start . 190) (:id . 80))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 207)\n  (:start . 198) (:id . 81))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 211) (:start . 208)\n  (:id . 82))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 213) (:start . 212)\n  (:id . 83))\n ((:tag . "NN") (:stem . "partner") (:form . "partner") (:end . 221)\n  (:start . 214) (:id . 84))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 225) (:start . 222)\n  (:id . 85))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 229) (:start . 226)\n  (:id . 86))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 234) (:start . 230)\n  (:id . 87))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 238) (:start . 235)\n  (:id . 88))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 239) (:start . 238)\n  (:id . 89)))@@@1@48@((:identifiers (:sid . :s9.43) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102616@unknown@formal@none@1@S@Akthar et al. [2] turned their focus towards the MOF protein as a potential candidate for interaction with roX2 RNA.@(((:tag . "NNP") (:stem . "Akthar") (:form . "Akthar") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "VBD") (:stem . "turn") (:form . "turned") (:end . 24) (:start . 18)\n  (:id . 48))\n ((:tag . "PRP$") (:stem . "their") (:form . "their") (:end . 30)\n  (:start . 25) (:id . 49))\n ((:tag . "NN") (:stem . "focus") (:form . "focus") (:end . 36) (:start . 31)\n  (:id . 50))\n ((:tag . "IN") (:stem . "towards") (:form . "towards") (:end . 44)\n  (:start . 37) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 48) (:start . 45)\n  (:id . 52))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 52) (:start . 49)\n  (:id . 53))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 60)\n  (:start . 53) (:id . 54))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 63) (:start . 61)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 65) (:start . 64)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "potential") (:form . "potential") (:end . 75)\n  (:start . 66) (:id . 57))\n ((:tag . "NN") (:stem . "candidate") (:form . "candidate") (:end . 85)\n  (:start . 76) (:id . 58))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 89) (:start . 86)\n  (:id . 59))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 101)\n  (:start . 90) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 111) (:start . 107)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 115) (:start . 112)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 116) (:start . 115)\n  (:id . 64)))@@@1@23@((:hcues ((:id . :x9.44.1) (:span 66 75)))\n (:hscopes ((:id . :x9.44.1) (:span 66 115)))\n (:identifiers (:sid . :s9.44) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102617@unknown@formal@none@1@S@MOF is the crucial component that links the DCC to the X-chromosome-specific acetylated form of histone H4.@(((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 6) (:start . 4)\n  (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 10) (:start . 7)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "crucial") (:form . "crucial") (:end . 18)\n  (:start . 11) (:id . 45))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 28)\n  (:start . 19) (:id . 46))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 33) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "link") (:form . "links") (:end . 39) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 50) (:start . 48)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 54) (:start . 51)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "x-chromosome-specific")\n  (:form . "X-chromosome-specific") (:end . 76) (:start . 55) (:id . 53))\n ((:tag . "VBN") (:stem . "acetylate") (:form . "acetylated") (:end . 87)\n  (:start . 77) (:id . 54))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 95) (:start . 93)\n  (:id . 56))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 103)\n  (:start . 96) (:id . 57))\n ((:tag . "NN") (:stem . "h4") (:form . "H4") (:end . 106) (:start . 104)\n  (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:identifiers (:sid . :s9.45) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102618@unknown@formal@none@1@S@MOF encodes an 827 amino-acid protein containing an amino terminus of unknown function, a chromodomain, a zinc finger and a carboxy-terminal histone acetyltransferase (HAT) domain.@(((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "encode") (:form . "encodes") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "CD") (:stem . "827") (:form . "827") (:end . 18) (:start . 15)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "amino-acid") (:form . "amino-acid") (:end . 29)\n  (:start . 19) (:id . 46))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 37)\n  (:start . 30) (:id . 47))\n ((:tag . "VBG") (:stem . "contain") (:form . "containing") (:end . 48)\n  (:start . 38) (:id . 48))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 51) (:start . 49)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 57) (:start . 52)\n  (:id . 50))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 66)\n  (:start . 58) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 77)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "function") (:form . "function") (:end . 86)\n  (:start . 78) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 87) (:start . 86)\n  (:id . 55))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 89) (:start . 88)\n  (:id . 56))\n ((:tag . "NN") (:stem . "chromodomain") (:form . "chromodomain") (:end . 102)\n  (:start . 90) (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 103) (:start . 102)\n  (:id . 58))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 105) (:start . 104)\n  (:id . 59))\n ((:tag . "NN") (:stem . "zinc") (:form . "zinc") (:end . 110) (:start . 106)\n  (:id . 60))\n ((:tag . "NN") (:stem . "finger") (:form . "finger") (:end . 117)\n  (:start . 111) (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 121) (:start . 118)\n  (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 123) (:start . 122)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "carboxy-terminal") (:form . "carboxy-terminal")\n  (:end . 140) (:start . 124) (:id . 64))\n ((:tag . "NN") (:stem . "histone") (:form . "histone") (:end . 148)\n  (:start . 141) (:id . 65))\n ((:tag . "NN") (:stem . "acetyltransferase") (:form . "acetyltransferase")\n  (:end . 166) (:start . 149) (:id . 66))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 168) (:start . 167)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "HAT") (:form . "HAT") (:end . 171) (:start . 168)\n  (:id . 68))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 172) (:start . 171)\n  (:id . 69))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 179)\n  (:start . 173) (:id . 70))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 180) (:start . 179)\n  (:id . 71)))@@@1@30@((:identifiers (:sid . :s9.46) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102620@unknown@formal@none@1@S@Interestingly, immunoprecipitation assays using extracts from SL-2 cells transfected with wild-type or mutant mof genes indicated that the chromodomain is essential for the specific interaction between MOF and roX2, but that the amino-terminal region and HAT domain were not essential for this interaction.@(((:tag . "RB") (:stem . "interestingly") (:form . "Interestingly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 34) (:start . 15) (:id . 44))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 41)\n  (:start . 35) (:id . 45))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 47) (:start . 42)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 56)\n  (:start . 48) (:id . 47))\n ((:tag . "IN") (:stem . "from") (:form . 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"indicated") (:end . 129)\n  (:start . 120) (:id . 58))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 134) (:start . 130)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 138) (:start . 135)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chromodomain") (:form . "chromodomain") (:end . 151)\n  (:start . 139) (:id . 61))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 154) (:start . 152)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 164)\n  (:start . 155) (:id . 63))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 168) (:start . 165)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 172) (:start . 169)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 181)\n  (:start . 173) (:id . 66))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 193)\n  (:start . 182) (:id . 67))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 201)\n  (:start . 194) (:id . 68))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 205) (:start . 202)\n  (:id . 69))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 209) (:start . 206)\n  (:id . 70))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 214) (:start . 210)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 215) (:start . 214)\n  (:id . 72))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 219) (:start . 216)\n  (:id . 73))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 224) (:start . 220)\n  (:id . 74))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 228) (:start . 225)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "amino-terminal") (:form . "amino-terminal")\n  (:end . 243) (:start . 229) (:id . 76))\n ((:tag . "NN") (:stem . "region") (:form . "region") (:end . 250)\n  (:start . 244) (:id . 77))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 254) (:start . 251)\n  (:id . 78))\n ((:tag . "NN") (:stem . "hat") (:form . "HAT") (:end . 258) (:start . 255)\n  (:id . 79))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 265)\n  (:start . 259) (:id . 80))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 270) (:start . 266)\n  (:id . 81))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 274) (:start . 271)\n  (:id . 82))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 284)\n  (:start . 275) (:id . 83))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 288) (:start . 285)\n  (:id . 84))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 293) (:start . 289)\n  (:id . 85))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 305)\n  (:start . 294) (:id . 86))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 306) (:start . 305)\n  (:id . 87)))@@@1@46@((:hcues ((:id . :x9.48.2) (:span 120 134)))\n (:ncues ((:id . :x9.48.1) (:span 271 274)))\n (:hscopes ((:id . :x9.48.2) (:span 120 305)))\n (:nscopes ((:id . :x9.48.1) (:span 271 305)))\n (:identifiers (:sid . :s9.48) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102621@unknown@formal@none@1@S@Akthar et al. [2] then tested the putative RNA-binding property of MOF directly using electromobility shift assays.@(((:tag . "NNP") (:stem . "Akthar") (:form . "Akthar") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 9) (:start . 7)\n  (:id . 43))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 13) (:start . 10)\n  (:id . 44))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 15) (:start . 14)\n  (:id . 45))\n ((:tag . "LS") (:stem . "2") (:form . "2") (:end . 16) (:start . 15)\n  (:id . 46))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 17) (:start . 16)\n  (:id . 47))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 22) (:start . 18)\n  (:id . 48))\n ((:tag . "VBD") (:stem . "test") (:form . "tested") (:end . 29) (:start . 23)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 33) (:start . 30)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "putative") (:form . "putative") (:end . 42)\n  (:start . 34) (:id . 51))\n ((:tag . "JJ") (:stem . "rna-binding") (:form . "RNA-binding") (:end . 54)\n  (:start . 43) (:id . 52))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 63)\n  (:start . 55) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "RB") (:stem . "directly") (:form . "directly") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 85) (:start . 80)\n  (:id . 57))\n ((:tag . "NN") (:stem . "electromobility") (:form . "electromobility")\n  (:end . 101) (:start . 86) (:id . 58))\n ((:tag . "NN") (:stem . "shift") (:form . "shift") (:end . 107)\n  (:start . 102) (:id . 59))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 114)\n  (:start . 108) (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 61)))@@@1@20@((:hcues ((:id . :x9.49.1) (:span 34 42)))\n (:hscopes ((:id . :x9.49.1) (:span 34 70)))\n (:identifiers (:sid . :s9.49) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102622@unknown@formal@none@1@S@MOF appeared to bind to RNA rather non-specifically, but preferred RNA to DNA.@(((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "VBD") (:stem . "appear") (:form . "appeared") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "VB") (:stem . "bind") (:form . "bind") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 27) (:start . 24)\n  (:id . 47))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 34)\n  (:start . 28) (:id . 48))\n ((:tag . "RB") (:stem . "non-specifically") (:form . "non-specifically")\n  (:end . 51) (:start . 35) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 52) (:start . 51)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 56) (:start . 53)\n  (:id . 51))\n ((:tag . "VBD") (:stem . "prefer") (:form . "preferred") (:end . 66)\n  (:start . 57) (:id . 52))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 70) (:start . 67)\n  (:id . 53))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 73) (:start . 71)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DNA") (:form . "DNA") (:end . 77) (:start . 74)\n  (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 78) (:start . 77)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x9.50.1) (:span 4 12)))\n (:hscopes ((:id . :x9.50.1) (:span 0 51)))\n (:identifiers (:sid . :s9.50) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102623@unknown@formal@none@1@S@In agreement with the immunoprecipitation results, they found that an intact chromodomain is essential for RNA binding, whereas the amino terminus or the HAT domain of MOF was not essential.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "agreement") (:form . "agreement") (:end . 12)\n  (:start . 3) (:id . 43))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "immunoprecipitation")\n  (:form . "immunoprecipitation") (:end . 41) (:start . 22) (:id . 46))\n ((:tag . "VBZ") (:stem . "result") (:form . "results") (:end . 49)\n  (:start . 42) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 50) (:start . 49)\n  (:id . 48))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 55) (:start . 51)\n  (:id . 49))\n ((:tag . "VBD") (:stem . "find") (:form . "found") (:end . 61) (:start . 56)\n  (:id . 50))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 66) (:start . 62)\n  (:id . 51))\n ((:tag . "DT") (:stem . "an") (:form . "an") (:end . 69) (:start . 67)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "intact") (:form . "intact") (:end . 76)\n  (:start . 70) (:id . 53))\n ((:tag . "NN") (:stem . "chromodomain") (:form . "chromodomain") (:end . 89)\n  (:start . 77) (:id . 54))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 92) (:start . 90)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 102)\n  (:start . 93) (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 106) (:start . 103)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 118)\n  (:start . 111) (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 119) (:start . 118)\n  (:id . 60))\n ((:tag . "IN") (:stem . "whereas") (:form . "whereas") (:end . 127)\n  (:start . 120) (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 131) (:start . 128)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "amino") (:form . "amino") (:end . 137)\n  (:start . 132) (:id . 63))\n ((:tag . "NN") (:stem . "terminus") (:form . "terminus") (:end . 146)\n  (:start . 138) (:id . 64))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 149) (:start . 147)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 153) (:start . 150)\n  (:id . 66))\n ((:tag . "NN") (:stem . "hat") (:form . "HAT") (:end . 157) (:start . 154)\n  (:id . 67))\n ((:tag . "NN") (:stem . "domain") (:form . "domain") (:end . 164)\n  (:start . 158) (:id . 68))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 167) (:start . 165)\n  (:id . 69))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 171) (:start . 168)\n  (:id . 70))\n ((:tag . "VBD") (:stem . "be") (:form . "was") (:end . 175) (:start . 172)\n  (:id . 71))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 179) (:start . 176)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 189)\n  (:start . 180) (:id . 73))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 190) (:start . 189)\n  (:id . 74)))@@@1@33@((:identifiers (:sid . :s9.51) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102624@unknown@formal@none@1@S@Furthermore, they also showed that MSL3, which features two chromodomains on its own, also shows roX RNA binding properties.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VBD") (:stem . "show") (:form . "showed") (:end . 29) (:start . 23)\n  (:id . 46))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 39) (:start . 35)\n  (:id . 48))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 49))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 46) (:start . 41)\n  (:id . 50))\n ((:tag . "VBZ") (:stem . "feature") (:form . "features") (:end . 55)\n  (:start . 47) (:id . 51))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "chromodomain") (:form . "chromodomains")\n  (:end . 73) (:start . 60) (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 76) (:start . 74)\n  (:id . 54))\n ((:tag . "PRP$") (:stem . "its") (:form . "its") (:end . 80) (:start . 77)\n  (:id . 55))\n ((:tag . "JJ") (:stem . "own") (:form . "own") (:end . 84) (:start . 81)\n  (:id . 56))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 85) (:start . 84)\n  (:id . 57))\n ((:tag . "RB") (:stem . "also") (:form . "also") (:end . 90) (:start . 86)\n  (:id . 58))\n ((:tag . "VBZ") (:stem . "show") (:form . "shows") (:end . 96) (:start . 91)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 100) (:start . 97)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 104) (:start . 101)\n  (:id . 61))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 112)\n  (:start . 105) (:id . 62))\n ((:tag . "NNS") (:stem . "property") (:form . "properties") (:end . 123)\n  (:start . 113) (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 124) (:start . 123)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s9.52) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102625@unknown@formal@none@1@S@Although the specificity of these interactions remains to be investigated, the findings of Akthar and coworkers [2] provide a new possible role for chromodomains involved in RNA binding.@(((:tag . "IN") (:stem . "although") (:form . "Although") (:end . 8)\n  (:start . 0) (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 12) (:start . 9)\n  (:id . 43))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 24)\n  (:start . 13) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 27) (:start . 25)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 33) (:start . 28)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 46)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "remain") (:form . "remains") (:end . 54)\n  (:start . 47) (:id . 48))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 57) (:start . 55)\n  (:id . 49))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 60) (:start . 58)\n  (:id . 50))\n ((:tag . "VBN") (:stem . "investigate") (:form . "investigated") (:end . 73)\n  (:start . 61) (:id . 51))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 74) (:start . 73)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 87)\n  (:start . 79) (:id . 54))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Akthar") (:form . "Akthar") (:end . 97)\n  (:start . 91) (:id . 56))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 101) (:start . 98)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "coworker") (:form . "coworkers") (:end . 111)\n  (:start . 102) (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 113) (:start . 112)\n  (:id . 59))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 114) (:start . 113)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 115) (:start . 114)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "provide") (:form . "provide") (:end . 123)\n  (:start . 116) (:id . 62))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 125) (:start . 124)\n  (:id . 63))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 129) (:start . 126)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 138)\n  (:start . 130) (:id . 65))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 147) (:start . 144)\n  (:id . 67))\n ((:tag . "NNS") (:stem . "chromodomain") (:form . "chromodomains")\n  (:end . 161) (:start . 148) (:id . 68))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 170)\n  (:start . 162) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 173) (:start . 171)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 177) (:start . 174)\n  (:id . 71))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 185)\n  (:start . 178) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 186) (:start . 185)\n  (:id . 73)))@@@1@32@((:hcues ((:id . :x9.53.1) (:span 130 138)) ((:id . :x9.53.2) (:span 47 73)))\n (:hscopes ((:id . :x9.53.1) (:span 130 185))\n  ((:id . :x9.53.2) (:span 13 73)))\n (:identifiers (:sid . :s9.53) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102626@unknown@formal@none@1@S@Chromodomains are modules of about 50 amino acids found in a number of proteins from yeast to mammals; the function of these proteins vary, but they are most often associated with gene silencing and chromatin remodeling events; significantly, many chromodomain-containing proteins are associated on chromosomes with heterochromatin or heterochromatin-like regions (reviewed in [17]).@(((:tag . "NNS") (:stem . "chromodomain") (:form . "Chromodomains")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 17) (:start . 14)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 25)\n  (:start . 18) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 28) (:start . 26)\n  (:id . 45))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 34) (:start . 29)\n  (:id . 46))\n ((:tag . "CD") (:stem . "50") (:form . "50") (:end . 37) (:start . 35)\n  (:id . 47))\n ((:tag . 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5102627@unknown@formal@none@1@S@The specific role of the chromodomain is unknown, but chromodomain swapping experiments in Drosophila suggest that they might be protein interaction modules [18].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 20) (:start . 18)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chromodomain") (:form . "chromodomain") (:end . 37)\n  (:start . 25) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "unknown") (:form . "unknown") (:end . 48)\n  (:start . 41) (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 49) (:start . 48)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 53) (:start . 50)\n  (:id . 51))\n ((:tag . "NN") (:stem . "chromodomain") (:form . "chromodomain") (:end . 66)\n  (:start . 54) (:id . 52))\n ((:tag . "NN") (:stem . "swapping") (:form . "swapping") (:end . 75)\n  (:start . 67) (:id . 53))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 87)\n  (:start . 76) (:id . 54))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 90) (:start . 88)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Drosophila") (:form . "Drosophila") (:end . 101)\n  (:start . 91) (:id . 56))\n ((:tag . "VBP") (:stem . "suggest") (:form . "suggest") (:end . 109)\n  (:start . 102) (:id . 57))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 114) (:start . 110)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 119) (:start . 115)\n  (:id . 59))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 125)\n  (:start . 120) (:id . 60))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 128) (:start . 126)\n  (:id . 61))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 136)\n  (:start . 129) (:id . 62))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 148)\n  (:start . 137) (:id . 63))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 156)\n  (:start . 149) (:id . 64))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 158) (:start . 157)\n  (:id . 65))\n ((:tag . "CD") (:stem . "18") (:form . "18") (:end . 160) (:start . 158)\n  (:id . 66))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 161) (:start . 160)\n  (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 162) (:start . 161)\n  (:id . 68)))@@@1@27@((:hcues ((:id . :x9.55.1) (:span 120 125)) ((:id . :x9.55.2) (:span 102 109))\n  ((:id . :x9.55.3) (:span 41 48)))\n (:hscopes ((:id . :x9.55.1) (:span 120 156))\n  ((:id . :x9.55.2) (:span 102 156)) ((:id . :x9.55.3) (:span 0 48)))\n (:identifiers (:sid . :s9.55) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102628@unknown@formal@none@1@S@Thus, the data by Akthar et al. [2] suggests a new and rather unexpected role for these modules in RNA binding.@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 9) (:start . 6)\n  (:id . 44))\n ((:tag . "NNS") (:stem . "datum") (:form . "data") (:end . 14) (:start . 10)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 17) (:start . 15)\n  (:id . 46))\n ((:tag . "NNP") (:stem . "Akthar") (:form . "Akthar") (:end . 24)\n  (:start . 18) (:id . 47))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 27) (:start . 25)\n  (:id . 48))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 31) (:start . 28)\n  (:id . 49))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 33) (:start . 32)\n  (:id . 50))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 34) (:start . 33)\n  (:id . 51))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 35) (:start . 34)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "suggest") (:form . "suggests") (:end . 44)\n  (:start . 36) (:id . 53))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 46) (:start . 45)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 50) (:start . 47)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 54) (:start . 51)\n  (:id . 56))\n ((:tag . "RB") (:stem . "rather") (:form . "rather") (:end . 61)\n  (:start . 55) (:id . 57))\n ((:tag . "JJ") (:stem . "unexpected") (:form . "unexpected") (:end . 72)\n  (:start . 62) (:id . 58))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 77) (:start . 73)\n  (:id . 59))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 81) (:start . 78)\n  (:id . 60))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 87) (:start . 82)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "module") (:form . "modules") (:end . 95)\n  (:start . 88) (:id . 62))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 98) (:start . 96)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 102) (:start . 99)\n  (:id . 64))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 110)\n  (:start . 103) (:id . 65))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 66)))@@@1@25@((:hcues ((:id . :x9.56.1) (:span 36 44)))\n (:hscopes ((:id . :x9.56.1) (:span 36 110)))\n (:identifiers (:sid . :s9.56) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102630@unknown@formal@none@1@S@Ordered assembly of MSL proteins and roX RNA increases stability of the DCC.@(((:tag . "VBN") (:stem . "order") (:form . "Ordered") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 16)\n  (:start . 8) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 19) (:start . 17)\n  (:id . 44))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 23) (:start . 20)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 32)\n  (:start . 24) (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 36) (:start . 33)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VBZ") (:stem . "increase") (:form . "increases") (:end . 54)\n  (:start . 45) (:id . 50))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 64)\n  (:start . 55) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 67) (:start . 65)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 75) (:start . 72)\n  (:id . 54))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 76) (:start . 75)\n  (:id . 55)))@@@1@14@((:identifiers (:sid . :s9.58) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|FigureLegend|)))@oe@9-2-2011
5102631@unknown@formal@none@1@S@The first step of assembly involves the recognition of about 35 chromosomal entry sites by a preDCC consisting of MSL1 and MSL2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 26)\n  (:start . 18) (:id . 46))\n ((:tag . "VBZ") (:stem . "involve") (:form . "involves") (:end . 35)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 51)\n  (:start . 40) (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "IN") (:stem . "about") (:form . "about") (:end . 60) (:start . 55)\n  (:id . 51))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 63) (:start . 61)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "chromosomal") (:form . "chromosomal") (:end . 75)\n  (:start . 64) (:id . 53))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 81) (:start . 76)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 87) (:start . 82)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 90) (:start . 88)\n  (:id . 56))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 92) (:start . 91)\n  (:id . 57))\n ((:tag . "NN") (:stem . "predcc") (:form . "preDCC") (:end . 99)\n  (:start . 93) (:id . 58))\n ((:tag . "VBG") (:stem . "consist") (:form . "consisting") (:end . 110)\n  (:start . 100) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 113) (:start . 111)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "MSL1") (:form . "MSL1") (:end . 118) (:start . 114)\n  (:id . 61))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MSL2") (:form . "MSL2") (:end . 127) (:start . 123)\n  (:id . 63))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 128) (:start . 127)\n  (:id . 64)))@@@1@23@((:identifiers (:sid . :s9.59) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102632@unknown@formal@none@1@S@This recognition does not require any of the known roX RNAs.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "recognition") (:form . "recognition") (:end . 16)\n  (:start . 5) (:id . 43))\n ((:tag . "VBZ") (:stem . "do") (:form . "does") (:end . 21) (:start . 17)\n  (:id . 44))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 25) (:start . 22)\n  (:id . 45))\n ((:tag . "VB") (:stem . "require") (:form . "require") (:end . 33)\n  (:start . 26) (:id . 46))\n ((:tag . "DT") (:stem . "any") (:form . "any") (:end . 37) (:start . 34)\n  (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 44) (:start . 41)\n  (:id . 49))\n ((:tag . "VBN") (:stem . "know") (:form . "known") (:end . 50) (:start . 45)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 54) (:start . 51)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 59) (:start . 55)\n  (:id . 52))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 60) (:start . 59)\n  (:id . 53)))@@@1@12@((:ncues ((:id . :x9.60.1) (:span 22 25)))\n (:nscopes ((:id . :x9.60.1) (:span 22 59)))\n (:identifiers (:sid . :s9.60) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102633@unknown@formal@none@1@S@In the next step, roX2 and MLE enter the complex to form a more stable primary DCC (PrimDCC) at these 35 sites.@(((:tag . "IN") (:stem . "in") (:form . "In") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 6) (:start . 3)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 11) (:start . 7)\n  (:id . 44))\n ((:tag . "NN") (:stem . "step") (:form . "step") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 46))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 22) (:start . 18)\n  (:id . 47))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 26) (:start . 23)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 30) (:start . 27)\n  (:id . 49))\n ((:tag . "VBP") (:stem . "enter") (:form . "enter") (:end . 36) (:start . 31)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 40) (:start . 37)\n  (:id . 51))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 48)\n  (:start . 41) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 51) (:start . 49)\n  (:id . 53))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 56) (:start . 52)\n  (:id . 54))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 58) (:start . 57)\n  (:id . 55))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 63) (:start . 59)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 70)\n  (:start . 64) (:id . 57))\n ((:tag . "JJ") (:stem . "primary") (:form . "primary") (:end . 78)\n  (:start . 71) (:id . 58))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 82) (:start . 79)\n  (:id . 59))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 84) (:start . 83)\n  (:id . 60))\n ((:tag . "NNP") (:stem . "PrimDCC") (:form . "PrimDCC") (:end . 91)\n  (:start . 84) (:id . 61))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 92) (:start . 91)\n  (:id . 62))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 95) (:start . 93)\n  (:id . 63))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 101) (:start . 96)\n  (:id . 64))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 104) (:start . 102)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 110)\n  (:start . 105) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 111) (:start . 110)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s9.61) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102634@unknown@formal@none@1@S@Spreading throughout the entire X chromosome requires the formation of the complete complex by addition of MOF and MSL3.@(((:tag . "VBG") (:stem . "spread") (:form . "Spreading") (:end . 9)\n  (:start . 0) (:id . 42))\n ((:tag . "IN") (:stem . "throughout") (:form . "throughout") (:end . 20)\n  (:start . 10) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 31)\n  (:start . 25) (:id . 45))\n ((:tag . "NN") (:stem . "x") (:form . "X") (:end . 33) (:start . 32)\n  (:id . 46))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 44)\n  (:start . 34) (:id . 47))\n ((:tag . "VBZ") (:stem . "require") (:form . "requires") (:end . 53)\n  (:start . 45) (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 57) (:start . 54)\n  (:id . 49))\n ((:tag . "NN") (:stem . "formation") (:form . "formation") (:end . 67)\n  (:start . 58) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 70) (:start . 68)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 74) (:start . 71)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "complete") (:form . "complete") (:end . 83)\n  (:start . 75) (:id . 53))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 91)\n  (:start . 84) (:id . 54))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 94) (:start . 92)\n  (:id . 55))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 103)\n  (:start . 95) (:id . 56))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 106) (:start . 104)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 110) (:start . 107)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 114) (:start . 111)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 119) (:start . 115)\n  (:id . 60))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 120) (:start . 119)\n  (:id . 61)))@@@1@20@((:identifiers (:sid . :s9.62) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102635@unknown@formal@none@1@S@The sequential addition of new components, particularly the roX2 RNA, might induce changes in the structure of already incorporated components (illustrated by ovals becoming circles), increasing the stability of the DCC.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "sequential") (:form . "sequential") (:end . 14)\n  (:start . 4) (:id . 43))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 26) (:start . 24)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 41)\n  (:start . 31) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 42) (:start . 41)\n  (:id . 48))\n ((:tag . "RB") (:stem . "particularly") (:form . "particularly") (:end . 55)\n  (:start . 43) (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 50))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 64) (:start . 60)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 69) (:start . 68)\n  (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 75) (:start . 70)\n  (:id . 54))\n ((:tag . "VB") (:stem . "induce") (:form . "induce") (:end . 82)\n  (:start . 76) (:id . 55))\n ((:tag . "NNS") (:stem . "change") (:form . "changes") (:end . 90)\n  (:start . 83) (:id . 56))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 93) (:start . 91)\n  (:id . 57))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 97) (:start . 94)\n  (:id . 58))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 107)\n  (:start . 98) (:id . 59))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 110) (:start . 108)\n  (:id . 60))\n ((:tag . "RB") (:stem . "already") (:form . "already") (:end . 118)\n  (:start . 111) (:id . 61))\n ((:tag . "VBN") (:stem . "incorporate") (:form . "incorporated") (:end . 131)\n  (:start . 119) (:id . 62))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 142)\n  (:start . 132) (:id . 63))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 144) (:start . 143)\n  (:id . 64))\n ((:tag . "VBN") (:stem . "illustrate") (:form . "illustrated") (:end . 155)\n  (:start . 144) (:id . 65))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 158) (:start . 156)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "oval") (:form . "ovals") (:end . 164)\n  (:start . 159) (:id . 67))\n ((:tag . "VBG") (:stem . "become") (:form . "becoming") (:end . 173)\n  (:start . 165) (:id . 68))\n ((:tag . "NNS") (:stem . "circle") (:form . "circles") (:end . 181)\n  (:start . 174) (:id . 69))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 182) (:start . 181)\n  (:id . 70))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 183) (:start . 182)\n  (:id . 71))\n ((:tag . "VBG") (:stem . "increase") (:form . "increasing") (:end . 194)\n  (:start . 184) (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 198) (:start . 195)\n  (:id . 73))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 208)\n  (:start . 199) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 211) (:start . 209)\n  (:id . 75))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 215) (:start . 212)\n  (:id . 76))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 219) (:start . 216)\n  (:id . 77))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 220) (:start . 219)\n  (:id . 78)))@@@1@37@((:hcues ((:id . :x9.63.1) (:span 70 75)))\n (:hscopes ((:id . :x9.63.1) (:span 70 219)))\n (:identifiers (:sid . :s9.63) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102636@unknown@formal@none@1@S@MLE might be removed in vitro (for example, by elevated ionic strength) without destroying the entire complex, because of the stabilizing presence of MOF-MSL3.@(((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 12) (:start . 10)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "remove") (:form . "removed") (:end . 20)\n  (:start . 13) (:id . 45))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 23) (:start . 21)\n  (:id . 46))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 29) (:start . 24)\n  (:id . 47))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 31) (:start . 30)\n  (:id . 48))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 34) (:start . 31)\n  (:id . 49))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 42)\n  (:start . 35) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 43) (:start . 42)\n  (:id . 51))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "elevated") (:form . "elevated") (:end . 55)\n  (:start . 47) (:id . 53))\n ((:tag . "JJ") (:stem . "ionic") (:form . "ionic") (:end . 61) (:start . 56)\n  (:id . 54))\n ((:tag . "NN") (:stem . "strength") (:form . "strength") (:end . 70)\n  (:start . 62) (:id . 55))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 71) (:start . 70)\n  (:id . 56))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 79)\n  (:start . 72) (:id . 57))\n ((:tag . "VBG") (:stem . "destroy") (:form . "destroying") (:end . 90)\n  (:start . 80) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 94) (:start . 91)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 101)\n  (:start . 95) (:id . 60))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 109)\n  (:start . 102) (:id . 61))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 110) (:start . 109)\n  (:id . 62))\n ((:tag . "IN") (:stem . "because") (:form . "because") (:end . 118)\n  (:start . 111) (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 121) (:start . 119)\n  (:id . 64))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 125) (:start . 122)\n  (:id . 65))\n ((:tag . "VBG") (:stem . "stabilize") (:form . "stabilizing") (:end . 137)\n  (:start . 126) (:id . 66))\n ((:tag . "NN") (:stem . "presence") (:form . "presence") (:end . 146)\n  (:start . 138) (:id . 67))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 149) (:start . 147)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "MOF-MSL3") (:form . "MOF-MSL3") (:end . 158)\n  (:start . 150) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 159) (:start . 158)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x9.64.2) (:span 4 9)))\n (:ncues ((:id . :x9.64.1) (:span 72 79)))\n (:hscopes ((:id . :x9.64.2) (:span 0 158)))\n (:nscopes ((:id . :x9.64.1) (:span 72 109)))\n (:identifiers (:sid . :s9.64) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102637@unknown@formal@none@1@S@The role of roX1 RNA is not clear, but it is integrated late in this process, together with or after MOF and MSL3; roX1 might provide additional stability to the mature DCC (MatDCC).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "role") (:form . "role") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 16) (:start . 12)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 20) (:start . 17)\n  (:id . 46))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 23) (:start . 21)\n  (:id . 47))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 27) (:start . 24)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "clear") (:form . "clear") (:end . 33) (:start . 28)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 34) (:start . 33)\n  (:id . 50))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 38) (:start . 35)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 41) (:start . 39)\n  (:id . 52))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 44) (:start . 42)\n  (:id . 53))\n ((:tag . "VBN") (:stem . "integrate") (:form . "integrated") (:end . 55)\n  (:start . 45) (:id . 54))\n ((:tag . "RB") (:stem . "late") (:form . "late") (:end . 60) (:start . 56)\n  (:id . 55))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 63) (:start . 61)\n  (:id . 56))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 68) (:start . 64)\n  (:id . 57))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 76)\n  (:start . 69) (:id . 58))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 77) (:start . 76)\n  (:id . 59))\n ((:tag . "RB") (:stem . "together") (:form . "together") (:end . 86)\n  (:start . 78) (:id . 60))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 91) (:start . 87)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 94) (:start . 92)\n  (:id . 62))\n ((:tag . "IN") (:stem . "after") (:form . "after") (:end . 100) (:start . 95)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 104) (:start . 101)\n  (:id . 64))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 108) (:start . 105)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 113) (:start . 109)\n  (:id . 66))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 114) (:start . 113)\n  (:id . 67))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 119) (:start . 115)\n  (:id . 68))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 125)\n  (:start . 120) (:id . 69))\n ((:tag . "VB") (:stem . "provide") (:form . "provide") (:end . 133)\n  (:start . 126) (:id . 70))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 144)\n  (:start . 134) (:id . 71))\n ((:tag . "NN") (:stem . "stability") (:form . "stability") (:end . 154)\n  (:start . 145) (:id . 72))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 157) (:start . 155)\n  (:id . 73))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 161) (:start . 158)\n  (:id . 74))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 168)\n  (:start . 162) (:id . 75))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 172) (:start . 169)\n  (:id . 76))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 174) (:start . 173)\n  (:id . 77))\n ((:tag . "NNP") (:stem . "MatDCC") (:form . "MatDCC") (:end . 180)\n  (:start . 174) (:id . 78))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 181) (:start . 180)\n  (:id . 79))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 182) (:start . 181)\n  (:id . 80)))@@@1@39@((:hcues ((:id . :x9.65.1) (:span 120 125)) ((:id . :x9.65.2) (:span 92 94))\n  ((:id . :x9.65.3) (:span 24 33)))\n (:hscopes ((:id . :x9.65.1) (:span 120 181))\n  ((:id . :x9.65.2) (:span 78 100)) ((:id . :x9.65.3) (:span 0 33)))\n (:identifiers (:sid . :s9.65) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102638@unknown@formal@none@1@S@So, roX1 and roX2 might be partially redundant.@(((:tag . "RB") (:stem . "so") (:form . "So") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 3) (:start . 2) (:id . 43))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 8) (:start . 4)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 12) (:start . 9)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 17) (:start . 13)\n  (:id . 46))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 23) (:start . 18)\n  (:id . 47))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 26) (:start . 24)\n  (:id . 48))\n ((:tag . "RB") (:stem . "partially") (:form . "partially") (:end . 36)\n  (:start . 27) (:id . 49))\n ((:tag . "JJ") (:stem . "redundant") (:form . "redundant") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 47) (:start . 46)\n  (:id . 51)))@@@1@10@((:hcues ((:id . :x9.66.1) (:span 18 23)))\n (:hscopes ((:id . :x9.66.1) (:span 18 46)))\n (:identifiers (:sid . :s9.66) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102640@unknown@formal@none@1@S@How can we reconcile the findings of Akthar et al. [2] and Meller et al. [1]?@(((:tag . "WRB") (:stem . "how") (:form . "How") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 7) (:start . 4)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "we") (:form . "we") (:end . 10) (:start . 8)\n  (:id . 44))\n ((:tag . "VB") (:stem . "reconcile") (:form . "reconcile") (:end . 20)\n  (:start . 11) (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "finding") (:form . "findings") (:end . 33)\n  (:start . 25) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 36) (:start . 34)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "Akthar") (:form . "Akthar") (:end . 43)\n  (:start . 37) (:id . 49))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 50) (:start . 47)\n  (:id . 51))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 52) (:start . 51)\n  (:id . 52))\n ((:tag . "CD") (:stem . "2") (:form . "2") (:end . 53) (:start . 52)\n  (:id . 53))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 54) (:start . 53)\n  (:id . 54))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 58) (:start . 55)\n  (:id . 55))\n ((:tag . "NNP") (:stem . "Meller") (:form . "Meller") (:end . 65)\n  (:start . 59) (:id . 56))\n ((:tag . "FW") (:stem . "et") (:form . "et") (:end . 68) (:start . 66)\n  (:id . 57))\n ((:tag . "FW") (:stem . "al.") (:form . "al.") (:end . 72) (:start . 69)\n  (:id . 58))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 74) (:start . 73)\n  (:id . 59))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 75) (:start . 74)\n  (:id . 60))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 76) (:start . 75)\n  (:id . 61))\n ((:tag . ".") (:stem . "?") (:form . "?") (:end . 77) (:start . 76)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s9.68) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102641@unknown@formal@none@1@S@First, it might be relevant that the co-immunoprecipitations and the in vitro binding experiments were performed with SL-2 cell extracts, cells in which dosage compensation appears not to be necessary; SL-2 cells, like other Drosophila cell lines, can become aneuploid without reduced viability.@(((:tag . "RB") (:stem . "first") (:form . "First") (:end . 5) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 6) (:start . 5) (:id . 43))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 9) (:start . 7)\n  (:id . 44))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 15) (:start . 10)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 18) (:start . 16)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "relevant") (:form . "relevant") (:end . 27)\n  (:start . 19) (:id . 47))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 32) (:start . 28)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "co-immunoprecipitation")\n  (:form . "co-immunoprecipitations") (:end . 60) (:start . 37) (:id . 50))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 68) (:start . 65)\n  (:id . 52))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 71) (:start . 69)\n  (:id . 53))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 77) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 85)\n  (:start . 78) (:id . 55))\n ((:tag . "NNS") (:stem . "experiment") (:form . "experiments") (:end . 97)\n  (:start . 86) (:id . 56))\n ((:tag . "VBD") (:stem . "be") (:form . "were") (:end . 102) (:start . 98)\n  (:id . 57))\n ((:tag . "VBN") (:stem . "perform") (:form . "performed") (:end . 112)\n  (:start . 103) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . 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"appears") (:end . 180)\n  (:start . 173) (:id . 69))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 184) (:start . 181)\n  (:id . 70))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 187) (:start . 185)\n  (:id . 71))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 190) (:start . 188)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "necessary") (:form . "necessary") (:end . 200)\n  (:start . 191) (:id . 73))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 201) (:start . 200)\n  (:id . 74))\n ((:tag . "NN") (:stem . "sl-2") (:form . "SL-2") (:end . 206) (:start . 202)\n  (:id . 75))\n ((:tag . "NNS") (:stem . "cell") (:form . "cells") (:end . 212)\n  (:start . 207) (:id . 76))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 213) (:start . 212)\n  (:id . 77))\n ((:tag . "IN") (:stem . "like") (:form . "like") (:end . 218) (:start . 214)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 224)\n  (:start . 219) (:id . 79))\n ((:tag . 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".") (:form . ".") (:end . 295) (:start . 294)\n  (:id . 90)))@@@1@49@((:hcues ((:id . :x9.69.2) (:span 173 180)) ((:id . :x9.69.4) (:span 10 15)))\n (:ncues ((:id . :x9.69.1) (:span 269 276))\n  ((:id . :x9.69.3) (:span 181 184)))\n (:hscopes ((:id . :x9.69.2) (:span 153 200))\n  ((:id . :x9.69.4) (:span 10 200)))\n (:nscopes ((:id . :x9.69.1) (:span 269 294))\n  ((:id . :x9.69.3) (:span 153 200)))\n (:identifiers (:sid . :s9.69) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102642@unknown@formal@none@1@S@The soluble DCCs from these extracts are therefore not necessarily functional and might differ from those in males.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "soluble") (:form . "soluble") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "dcc") (:form . "DCCs") (:end . 16) (:start . 12)\n  (:id . 44))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 21) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 27) (:start . 22)\n  (:id . 46))\n ((:tag . "NNS") (:stem . "extract") (:form . "extracts") (:end . 36)\n  (:start . 28) (:id . 47))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 40) (:start . 37)\n  (:id . 48))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 54) (:start . 51)\n  (:id . 50))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 66)\n  (:start . 55) (:id . 51))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 77)\n  (:start . 67) (:id . 52))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 81) (:start . 78)\n  (:id . 53))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 87) (:start . 82)\n  (:id . 54))\n ((:tag . "VB") (:stem . "differ") (:form . "differ") (:end . 94)\n  (:start . 88) (:id . 55))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 99) (:start . 95)\n  (:id . 56))\n ((:tag . "DT") (:stem . "those") (:form . "those") (:end . 105)\n  (:start . 100) (:id . 57))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 58))\n ((:tag . "NNS") (:stem . "male") (:form . "males") (:end . 114)\n  (:start . 109) (:id . 59))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 115) (:start . 114)\n  (:id . 60)))@@@1@19@((:hcues ((:id . :x9.70.1) (:span 82 87)))\n (:ncues ((:id . :x9.70.2) (:span 51 54)))\n (:hscopes ((:id . :x9.70.1) (:span 82 114)))\n (:nscopes ((:id . :x9.70.2) (:span 51 77)))\n (:identifiers (:sid . :s9.70) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102643@unknown@formal@none@1@S@Second, the interaction between roX RNA and MOF protein appears to lack specificity.@(((:tag . "RB") (:stem . "second") (:form . "Second") (:end . 6) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 7) (:start . 6) (:id . 43))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 11) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "interaction") (:form . "interaction") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 31)\n  (:start . 24) (:id . 46))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 35) (:start . 32)\n  (:id . 47))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 39) (:start . 36)\n  (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 47) (:start . 44)\n  (:id . 50))\n ((:tag . "NN") (:stem . "protein") (:form . "protein") (:end . 55)\n  (:start . 48) (:id . 51))\n ((:tag . "VBZ") (:stem . "appear") (:form . "appears") (:end . 63)\n  (:start . 56) (:id . 52))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 66) (:start . 64)\n  (:id . 53))\n ((:tag . "VB") (:stem . "lack") (:form . "lack") (:end . 71) (:start . 67)\n  (:id . 54))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 83)\n  (:start . 72) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 84) (:start . 83)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x9.71.2) (:span 56 63)))\n (:ncues ((:id . :x9.71.1) (:span 67 71)))\n (:hscopes ((:id . :x9.71.2) (:span 8 83)))\n (:nscopes ((:id . :x9.71.1) (:span 67 83)))\n (:identifiers (:sid . :s9.71) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102644@unknown@formal@none@1@S@The lack of specificity might be attributed to a number of reasons, such as the absence of other MSL components, the presence of other RNAs interacting with MOF, or worse, it might reflect a property of MOF without functional significance: that is, MOF might not contact RNA at all in vivo.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "lack") (:form . "lack") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 11) (:start . 9)\n  (:id . 44))\n ((:tag . "NN") (:stem . "specificity") (:form . "specificity") (:end . 23)\n  (:start . 12) (:id . 45))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 29) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 32) (:start . 30)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "attribute") (:form . "attributed") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . 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"with") (:end . 156) (:start . 152)\n  (:id . 70))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 160) (:start . 157)\n  (:id . 71))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 161) (:start . 160)\n  (:id . 72))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 164) (:start . 162)\n  (:id . 73))\n ((:tag . "JJR") (:stem . "worse") (:form . "worse") (:end . 170)\n  (:start . 165) (:id . 74))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 171) (:start . 170)\n  (:id . 75))\n ((:tag . "PRP") (:stem . "it") (:form . "it") (:end . 174) (:start . 172)\n  (:id . 76))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 180)\n  (:start . 175) (:id . 77))\n ((:tag . "VB") (:stem . "reflect") (:form . "reflect") (:end . 188)\n  (:start . 181) (:id . 78))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 190) (:start . 189)\n  (:id . 79))\n ((:tag . "NN") (:stem . "property") (:form . "property") (:end . 199)\n  (:start . 191) (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 202) (:start . 200)\n  (:id . 81))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 206) (:start . 203)\n  (:id . 82))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 214)\n  (:start . 207) (:id . 83))\n ((:tag . "JJ") (:stem . "functional") (:form . "functional") (:end . 225)\n  (:start . 215) (:id . 84))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 238)\n  (:start . 226) (:id . 85))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 239) (:start . 238)\n  (:id . 86))\n ((:tag . "DT") (:stem . "that") (:form . "that") (:end . 244) (:start . 240)\n  (:id . 87))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 247) (:start . 245)\n  (:id . 88))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 248) (:start . 247)\n  (:id . 89))\n ((:tag . "NN") (:stem . "mof") (:form . "MOF") (:end . 252) (:start . 249)\n  (:id . 90))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 258)\n  (:start . 253) (:id . 91))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 262) (:start . 259)\n  (:id . 92))\n ((:tag . "VB") (:stem . "contact") (:form . "contact") (:end . 270)\n  (:start . 263) (:id . 93))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 274) (:start . 271)\n  (:id . 94))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 277) (:start . 275)\n  (:id . 95))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 281) (:start . 278)\n  (:id . 96))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 284) (:start . 282)\n  (:id . 97))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 289) (:start . 285)\n  (:id . 98))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 290) (:start . 289)\n  (:id . 99)))@@@1@58@((:hcues ((:id . :x9.72.2) (:span 253 258)) ((:id . :x9.72.4) (:span 175 180))\n  ((:id . :x9.72.7) (:span 24 29)))\n (:ncues ((:id . :x9.72.1) (:span 259 262)) ((:id . :x9.72.3) (:span 207 214))\n  ((:id . :x9.72.5) (:span 80 87)) ((:id . :x9.72.6) (:span 4 8)))\n (:hscopes ((:id . :x9.72.2) (:span 253 289))\n  ((:id . :x9.72.4) (:span 175 289)) ((:id . :x9.72.7) (:span 4 23)))\n (:nscopes ((:id . :x9.72.1) (:span 259 289))\n  ((:id . :x9.72.3) (:span 207 238)) ((:id . :x9.72.5) (:span 80 111))\n  ((:id . :x9.72.6) (:span 4 160)))\n (:identifiers (:sid . :s9.72) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102645@unknown@formal@none@1@S@Keeping this cautious note in mind, a more attractive alternative could be envisioned.@(((:tag . "VBG") (:stem . "keep") (:form . "Keeping") (:end . 7) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 12) (:start . 8)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "cautious") (:form . "cautious") (:end . 21)\n  (:start . 13) (:id . 44))\n ((:tag . "NN") (:stem . "note") (:form . "note") (:end . 26) (:start . 22)\n  (:id . 45))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 29) (:start . 27)\n  (:id . 46))\n ((:tag . "NN") (:stem . "mind") (:form . "mind") (:end . 34) (:start . 30)\n  (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 35) (:start . 34)\n  (:id . 48))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 37) (:start . 36)\n  (:id . 49))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 42) (:start . 38)\n  (:id . 50))\n ((:tag . "JJ") (:stem . "attractive") (:form . "attractive") (:end . 53)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "alternative") (:form . "alternative") (:end . 65)\n  (:start . 54) (:id . 52))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 71) (:start . 66)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "VBN") (:stem . "envision") (:form . "envisioned") (:end . 85)\n  (:start . 75) (:id . 55))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 86) (:start . 85)\n  (:id . 56)))@@@1@15@((:hcues ((:id . :x9.73.1) (:span 66 71)))\n (:hscopes ((:id . :x9.73.1) (:span 36 85)))\n (:identifiers (:sid . :s9.73) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102646@unknown@formal@none@1@S@The main proposition of this model is that roX2 can interact with both MLE and MOF, and perhaps even other MSL proteins, as both roX RNAs are certainly large enough to accommodate binding sites for several proteins [6].@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "main") (:form . "main") (:end . 8) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "proposition") (:form . "proposition") (:end . 20)\n  (:start . 9) (:id . 44))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 28) (:start . 24)\n  (:id . 46))\n ((:tag . "NN") (:stem . "model") (:form . "model") (:end . 34) (:start . 29)\n  (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 37) (:start . 35)\n  (:id . 48))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 42) (:start . 38)\n  (:id . 49))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 47) (:start . 43)\n  (:id . 50))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 51) (:start . 48)\n  (:id . 51))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 60)\n  (:start . 52) (:id . 52))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 65) (:start . 61)\n  (:id . 53))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 70) (:start . 66)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 74) (:start . 71)\n  (:id . 55))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 78) (:start . 75)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 82) (:start . 79)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 87) (:start . 84)\n  (:id . 59))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 95)\n  (:start . 88) (:id . 60))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 100) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 106)\n  (:start . 101) (:id . 62))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 110) (:start . 107)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 119)\n  (:start . 111) (:id . 64))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 120) (:start . 119)\n  (:id . 65))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 123) (:start . 121)\n  (:id . 66))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 128) (:start . 124)\n  (:id . 67))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 132) (:start . 129)\n  (:id . 68))\n ((:tag . "NNPS") (:stem . "RNA") (:form . "RNAs") (:end . 137) (:start . 133)\n  (:id . 69))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 141) (:start . 138)\n  (:id . 70))\n ((:tag . "RB") (:stem . "certainly") (:form . "certainly") (:end . 151)\n  (:start . 142) (:id . 71))\n ((:tag . "JJ") (:stem . "large") (:form . "large") (:end . 157)\n  (:start . 152) (:id . 72))\n ((:tag . "RB") (:stem . "enough") (:form . "enough") (:end . 164)\n  (:start . 158) (:id . 73))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 167) (:start . 165)\n  (:id . 74))\n ((:tag . "VB") (:stem . "accommodate") (:form . "accommodate") (:end . 179)\n  (:start . 168) (:id . 75))\n ((:tag . "VBG") (:stem . "bind") (:form . "binding") (:end . 187)\n  (:start . 180) (:id . 76))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 193)\n  (:start . 188) (:id . 77))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 197) (:start . 194)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 205)\n  (:start . 198) (:id . 79))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 214)\n  (:start . 206) (:id . 80))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 216) (:start . 215)\n  (:id . 81))\n ((:tag . "CD") (:stem . "6") (:form . "6") (:end . 217) (:start . 216)\n  (:id . 82))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 218) (:start . 217)\n  (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 219) (:start . 218)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x9.74.1) (:span 88 95)))\n (:hscopes ((:id . :x9.74.1) (:span 88 119)))\n (:identifiers (:sid . :s9.74) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102647@unknown@formal@none@1@S@If such a scenario is correct, each of the interactions between different components of the DCC might be quite weak, and perhaps not even highly specific, but in the context of additional interactions becomes more stable.@(((:tag . "IN") (:stem . "if") (:form . "If") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 7) (:start . 3)\n  (:id . 43))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 9) (:start . 8)\n  (:id . 44))\n ((:tag . "NN") (:stem . "scenario") (:form . "scenario") (:end . 18)\n  (:start . 10) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "JJ") (:stem . "correct") (:form . "correct") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 30) (:start . 29)\n  (:id . 48))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 35) (:start . 31)\n  (:id . 49))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 38) (:start . 36)\n  (:id . 50))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 55)\n  (:start . 43) (:id . 52))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 63)\n  (:start . 56) (:id . 53))\n ((:tag . "JJ") (:stem . "different") (:form . "different") (:end . 73)\n  (:start . 64) (:id . 54))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 84)\n  (:start . 74) (:id . 55))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 87) (:start . 85)\n  (:id . 56))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 95) (:start . 92)\n  (:id . 58))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 101) (:start . 96)\n  (:id . 59))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 104) (:start . 102)\n  (:id . 60))\n ((:tag . "RB") (:stem . "quite") (:form . "quite") (:end . 110)\n  (:start . 105) (:id . 61))\n ((:tag . "JJ") (:stem . "weak") (:form . "weak") (:end . 115) (:start . 111)\n  (:id . 62))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 116) (:start . 115)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 120) (:start . 117)\n  (:id . 64))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 128)\n  (:start . 121) (:id . 65))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 132) (:start . 129)\n  (:id . 66))\n ((:tag . "RB") (:stem . "even") (:form . "even") (:end . 137) (:start . 133)\n  (:id . 67))\n ((:tag . "RB") (:stem . "highly") (:form . "highly") (:end . 144)\n  (:start . 138) (:id . 68))\n ((:tag . "JJ") (:stem . "specific") (:form . "specific") (:end . 153)\n  (:start . 145) (:id . 69))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 154) (:start . 153)\n  (:id . 70))\n ((:tag . "CC") (:stem . "but") (:form . "but") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 161) (:start . 159)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 165) (:start . 162)\n  (:id . 73))\n ((:tag . "NN") (:stem . "context") (:form . "context") (:end . 173)\n  (:start . 166) (:id . 74))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 176) (:start . 174)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "additional") (:form . "additional") (:end . 187)\n  (:start . 177) (:id . 76))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 200)\n  (:start . 188) (:id . 77))\n ((:tag . "VBZ") (:stem . "become") (:form . "becomes") (:end . 208)\n  (:start . 201) (:id . 78))\n ((:tag . "RBR") (:stem . "more") (:form . "more") (:end . 213) (:start . 209)\n  (:id . 79))\n ((:tag . "JJ") (:stem . "stable") (:form . "stable") (:end . 220)\n  (:start . 214) (:id . 80))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 221) (:start . 220)\n  (:id . 81)))@@@1@40@((:hcues ((:id . :x9.75.2) (:span 121 128)) ((:id . :x9.75.3) (:span 96 101)))\n (:ncues ((:id . :x9.75.1) (:span 129 132)))\n (:hscopes ((:id . :x9.75.2) (:span 121 153))\n  ((:id . :x9.75.3) (:span 96 115)))\n (:nscopes ((:id . :x9.75.1) (:span 129 153)))\n (:identifiers (:sid . :s9.75) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102648@unknown@formal@none@1@S@The addition of each new component might therefore strengthen existing interactions by optimizing contacts between binding surfaces through adjustments in the higher-order structure of the components (Figure 1).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "DT") (:stem . "each") (:form . "each") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "JJ") (:stem . "new") (:form . "new") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 34)\n  (:start . 25) (:id . 47))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 40) (:start . 35)\n  (:id . 48))\n ((:tag . "RB") (:stem . "therefore") (:form . "therefore") (:end . 50)\n  (:start . 41) (:id . 49))\n ((:tag . "VB") (:stem . "strengthen") (:form . "strengthen") (:end . 61)\n  (:start . 51) (:id . 50))\n ((:tag . "VBG") (:stem . "exist") (:form . "existing") (:end . 70)\n  (:start . 62) (:id . 51))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 83)\n  (:start . 71) (:id . 52))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 86) (:start . 84)\n  (:id . 53))\n ((:tag . "VBG") (:stem . "optimize") (:form . "optimizing") (:end . 97)\n  (:start . 87) (:id . 54))\n ((:tag . "NNS") (:stem . "contact") (:form . "contacts") (:end . 106)\n  (:start . 98) (:id . 55))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 114)\n  (:start . 107) (:id . 56))\n ((:tag . "NN") (:stem . "binding") (:form . "binding") (:end . 122)\n  (:start . 115) (:id . 57))\n ((:tag . "NNS") (:stem . "surface") (:form . "surfaces") (:end . 131)\n  (:start . 123) (:id . 58))\n ((:tag . "IN") (:stem . "through") (:form . "through") (:end . 139)\n  (:start . 132) (:id . 59))\n ((:tag . "NNS") (:stem . "adjustment") (:form . "adjustments") (:end . 151)\n  (:start . 140) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 154) (:start . 152)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 62))\n ((:tag . "JJR") (:stem . "higher-ord") (:form . "higher-order") (:end . 171)\n  (:start . 159) (:id . 63))\n ((:tag . "NN") (:stem . "structure") (:form . "structure") (:end . 181)\n  (:start . 172) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 184) (:start . 182)\n  (:id . 65))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 188) (:start . 185)\n  (:id . 66))\n ((:tag . "NNS") (:stem . "component") (:form . "components") (:end . 199)\n  (:start . 189) (:id . 67))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 201) (:start . 200)\n  (:id . 68))\n ((:tag . "NNP") (:stem . "Figure") (:form . "Figure") (:end . 207)\n  (:start . 201) (:id . 69))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 209) (:start . 208)\n  (:id . 70))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 210) (:start . 209)\n  (:id . 71))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 72)))@@@1@31@((:hcues ((:id . :x9.76.1) (:span 35 40)))\n (:hscopes ((:id . :x9.76.1) (:span 35 199)))\n (:identifiers (:sid . :s9.76) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102650@unknown@formal@none@1@S@The addition of both MLE and roX2 RNA might allow the formation of a primary complex (the primDCC), which might be stabilized by the direct interaction of a structural motif of roX2 RNA with the MLE protein, as well as interactions of this complex with MSL1 and MSL2.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 15) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "both") (:form . "both") (:end . 20) (:start . 16)\n  (:id . 45))\n ((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 24) (:start . 21)\n  (:id . 46))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 28) (:start . 25)\n  (:id . 47))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 33) (:start . 29)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "RNA") (:form . 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"with") (:end . 252) (:start . 248)\n  (:id . 90))\n ((:tag . "NNP") (:stem . "MSL1") (:form . "MSL1") (:end . 257) (:start . 253)\n  (:id . 91))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 261) (:start . 258)\n  (:id . 92))\n ((:tag . "NNP") (:stem . "MSL2") (:form . "MSL2") (:end . 266) (:start . 262)\n  (:id . 93))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 267) (:start . 266)\n  (:id . 94)))@@@1@53@((:hcues ((:id . :x9.78.1) (:span 106 111)) ((:id . :x9.78.2) (:span 38 43)))\n (:hscopes ((:id . :x9.78.1) (:span 100 266))\n  ((:id . :x9.78.2) (:span 38 98)))\n (:identifiers (:sid . :s9.78) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102651@unknown@formal@none@1@S@The primDCC might then be reinforced by the addition of the remaining two proteins, MSL3 and MOF, one or both of which might recognize other motifs within the roX2 RNA, to form the mature complex (matDCC).@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "primdcc") (:form . "primDCC") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 17) (:start . 12)\n  (:id . 44))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 25) (:start . 23)\n  (:id . 46))\n ((:tag . "VBN") (:stem . "reinforce") (:form . "reinforced") (:end . 36)\n  (:start . 26) (:id . 47))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 39) (:start . 37)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 43) (:start . 40)\n  (:id . 49))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 52)\n  (:start . 44) (:id . 50))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 55) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 59) (:start . 56)\n  (:id . 52))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 69)\n  (:start . 60) (:id . 53))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 73) (:start . 70)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 82)\n  (:start . 74) (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 83) (:start . 82)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "MSL3") (:form . "MSL3") (:end . 88) (:start . 84)\n  (:id . 57))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 92) (:start . 89)\n  (:id . 58))\n ((:tag . "NNP") (:stem . "MOF") (:form . "MOF") (:end . 96) (:start . 93)\n  (:id . 59))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 97) (:start . 96)\n  (:id . 60))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 101) (:start . 98)\n  (:id . 61))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 104) (:start . 102)\n  (:id . 62))\n ((:tag . "DT") (:stem . "both") (:form . "both") (:end . 109) (:start . 105)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 112) (:start . 110)\n  (:id . 64))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 118)\n  (:start . 113) (:id . 65))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 124)\n  (:start . 119) (:id . 66))\n ((:tag . "VB") (:stem . "recognize") (:form . "recognize") (:end . 134)\n  (:start . 125) (:id . 67))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 140)\n  (:start . 135) (:id . 68))\n ((:tag . "NNS") (:stem . "motif") (:form . "motifs") (:end . 147)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "within") (:form . "within") (:end . 154)\n  (:start . 148) (:id . 70))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 158) (:start . 155)\n  (:id . 71))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 163) (:start . 159)\n  (:id . 72))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 167) (:start . 164)\n  (:id . 73))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 168) (:start . 167)\n  (:id . 74))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 171) (:start . 169)\n  (:id . 75))\n ((:tag . "VB") (:stem . "form") (:form . "form") (:end . 176) (:start . 172)\n  (:id . 76))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 180) (:start . 177)\n  (:id . 77))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 187)\n  (:start . 181) (:id . 78))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 195)\n  (:start . 188) (:id . 79))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 197) (:start . 196)\n  (:id . 80))\n ((:tag . "NN") (:stem . "matdcc") (:form . "matDCC") (:end . 203)\n  (:start . 197) (:id . 81))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 204) (:start . 203)\n  (:id . 82))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 205) (:start . 204)\n  (:id . 83)))@@@1@42@((:hcues ((:id . :x9.79.1) (:span 119 124)) ((:id . :x9.79.2) (:span 102 104))\n  ((:id . :x9.79.3) (:span 12 17)))\n (:hscopes ((:id . :x9.79.1) (:span 119 204))\n  ((:id . :x9.79.2) (:span 98 109)) ((:id . :x9.79.3) (:span 0 96)))\n (:identifiers (:sid . :s9.79) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102652@unknown@formal@none@1@S@Finally, matDCC might be further stabilized by the addition of roX1 RNA, which could interact with several of the MSLs and perhaps roX2 RNA as well.@(((:tag . "RB") (:stem . "finally") (:form . "Finally") (:end . 7)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 8) (:start . 7) (:id . 43))\n ((:tag . "NN") (:stem . "matdcc") (:form . "matDCC") (:end . 15) (:start . 9)\n  (:id . 44))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 21) (:start . 16)\n  (:id . 45))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 24) (:start . 22)\n  (:id . 46))\n ((:tag . "RBR") (:stem . "further") (:form . "further") (:end . 32)\n  (:start . 25) (:id . 47))\n ((:tag . "VBN") (:stem . "stabilize") (:form . "stabilized") (:end . 43)\n  (:start . 33) (:id . 48))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 46) (:start . 44)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 50) (:start . 47)\n  (:id . 50))\n ((:tag . "NN") (:stem . "addition") (:form . "addition") (:end . 59)\n  (:start . 51) (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 62) (:start . 60)\n  (:id . 52))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 67) (:start . 63)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 71) (:start . 68)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 72) (:start . 71)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 78) (:start . 73)\n  (:id . 56))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 84) (:start . 79)\n  (:id . 57))\n ((:tag . "VB") (:stem . "interact") (:form . "interact") (:end . 93)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 98) (:start . 94)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "several") (:form . "several") (:end . 106)\n  (:start . 99) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 109) (:start . 107)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 113) (:start . 110)\n  (:id . 62))\n ((:tag . "NNPS") (:stem . "MSL") (:form . "MSLs") (:end . 118) (:start . 114)\n  (:id . 63))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 122) (:start . 119)\n  (:id . 64))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 130)\n  (:start . 123) (:id . 65))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 135) (:start . 131)\n  (:id . 66))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNA") (:end . 139) (:start . 136)\n  (:id . 67))\n ((:tag . "RB") (:stem . "as") (:form . "as") (:end . 142) (:start . 140)\n  (:id . 68))\n ((:tag . "RB") (:stem . "well") (:form . "well") (:end . 147) (:start . 143)\n  (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 148) (:start . 147)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x9.80.1) (:span 79 84)) ((:id . :x9.80.2) (:span 16 21)))\n (:hscopes ((:id . :x9.80.1) (:span 79 147)) ((:id . :x9.80.2) (:span 9 147)))\n (:identifiers (:sid . :s9.80) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102653@unknown@formal@none@1@S@Significantly, assembly and disassembly of the complex might not necessarily follow the same order.@(((:tag . "RB") (:stem . "significantly") (:form . "Significantly")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "NN") (:stem . "assembly") (:form . "assembly") (:end . 23)\n  (:start . 15) (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 27) (:start . 24)\n  (:id . 45))\n ((:tag . "NN") (:stem . "disassembly") (:form . "disassembly") (:end . 39)\n  (:start . 28) (:id . 46))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 42) (:start . 40)\n  (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 46) (:start . 43)\n  (:id . 48))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 54)\n  (:start . 47) (:id . 49))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 60) (:start . 55)\n  (:id . 50))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 64) (:start . 61)\n  (:id . 51))\n ((:tag . "RB") (:stem . "necessarily") (:form . "necessarily") (:end . 76)\n  (:start . 65) (:id . 52))\n ((:tag . "VB") (:stem . "follow") (:form . "follow") (:end . 83)\n  (:start . 77) (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 87) (:start . 84)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 92) (:start . 88)\n  (:id . 55))\n ((:tag . "NN") (:stem . "order") (:form . "order") (:end . 98) (:start . 93)\n  (:id . 56))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 99) (:start . 98)\n  (:id . 57)))@@@1@16@((:hcues ((:id . :x9.81.2) (:span 55 60)))\n (:ncues ((:id . :x9.81.1) (:span 61 64)))\n (:hscopes ((:id . :x9.81.2) (:span 55 98)))\n (:nscopes ((:id . :x9.81.1) (:span 61 98)))\n (:identifiers (:sid . :s9.81) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102654@unknown@formal@none@1@S@For example, once the complex is formed, removal (for example, by high ionic strength) of a single component brought in relatively early (such as MLE) might be possible without affecting the rest of the complex.@(((:tag . "IN") (:stem . "for") (:form . "For") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 11)\n  (:start . 4) (:id . 43))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 44))\n ((:tag . "RB") (:stem . "once") (:form . "once") (:end . 17) (:start . 13)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "form") (:form . "formed") (:end . 39) (:start . 33)\n  (:id . 49))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 50))\n ((:tag . "NN") (:stem . "removal") (:form . "removal") (:end . 48)\n  (:start . 41) (:id . 51))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 50) (:start . 49)\n  (:id . 52))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 53) (:start . 50)\n  (:id . 53))\n ((:tag . "NN") (:stem . "example") (:form . "example") (:end . 61)\n  (:start . 54) (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 62) (:start . 61)\n  (:id . 55))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 65) (:start . 63)\n  (:id . 56))\n ((:tag . "JJ") (:stem . "high") (:form . "high") (:end . 70) (:start . 66)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "ionic") (:form . "ionic") (:end . 76) (:start . 71)\n  (:id . 58))\n ((:tag . "NN") (:stem . "strength") (:form . "strength") (:end . 85)\n  (:start . 77) (:id . 59))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 86) (:start . 85)\n  (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 89) (:start . 87)\n  (:id . 61))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 91) (:start . 90)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "single") (:form . "single") (:end . 98)\n  (:start . 92) (:id . 63))\n ((:tag . "NN") (:stem . "component") (:form . "component") (:end . 108)\n  (:start . 99) (:id . 64))\n ((:tag . "VBN") (:stem . "bring") (:form . "brought") (:end . 116)\n  (:start . 109) (:id . 65))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 119) (:start . 117)\n  (:id . 66))\n ((:tag . "RB") (:stem . "relatively") (:form . "relatively") (:end . 130)\n  (:start . 120) (:id . 67))\n ((:tag . "JJ") (:stem . "early") (:form . "early") (:end . 136)\n  (:start . 131) (:id . 68))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 138) (:start . 137)\n  (:id . 69))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 142) (:start . 138)\n  (:id . 70))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 145) (:start . 143)\n  (:id . 71))\n ((:tag . "NNP") (:stem . "MLE") (:form . "MLE") (:end . 149) (:start . 146)\n  (:id . 72))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 150) (:start . 149)\n  (:id . 73))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 156)\n  (:start . 151) (:id . 74))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 159) (:start . 157)\n  (:id . 75))\n ((:tag . "JJ") (:stem . "possible") (:form . "possible") (:end . 168)\n  (:start . 160) (:id . 76))\n ((:tag . "IN") (:stem . "without") (:form . "without") (:end . 176)\n  (:start . 169) (:id . 77))\n ((:tag . "VBG") (:stem . "affect") (:form . "affecting") (:end . 186)\n  (:start . 177) (:id . 78))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 190) (:start . 187)\n  (:id . 79))\n ((:tag . "NN") (:stem . "rest") (:form . "rest") (:end . 195) (:start . 191)\n  (:id . 80))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 198) (:start . 196)\n  (:id . 81))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 202) (:start . 199)\n  (:id . 82))\n ((:tag . "NN") (:stem . "complex") (:form . "complex") (:end . 210)\n  (:start . 203) (:id . 83))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 211) (:start . 210)\n  (:id . 84)))@@@1@43@((:hcues ((:id . :x9.82.2) (:span 151 156 160 168)))\n (:ncues ((:id . :x9.82.1) (:span 169 176)))\n (:hscopes ((:id . :x9.82.2) (:span 41 210)))\n (:nscopes ((:id . :x9.82.1) (:span 169 210)))\n (:identifiers (:sid . :s9.82) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102655@unknown@formal@none@1@S@One major task at hand now will be to resolve the specificities of the proposed interactions between the various MSL proteins and the roX RNAs.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "major") (:form . "major") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "task") (:form . "task") (:end . 14) (:start . 10)\n  (:id . 44))\n ((:tag . "IN") (:stem . "at") (:form . "at") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "NN") (:stem . "hand") (:form . "hand") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "now") (:form . "now") (:end . 26) (:start . 23)\n  (:id . 47))\n ((:tag . "MD") (:stem . "will") (:form . "will") (:end . 31) (:start . 27)\n  (:id . 48))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 34) (:start . 32)\n  (:id . 49))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 37) (:start . 35)\n  (:id . 50))\n ((:tag . "VB") (:stem . "resolve") (:form . "resolve") (:end . 45)\n  (:start . 38) (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 49) (:start . 46)\n  (:id . 52))\n ((:tag . "NNS") (:stem . "specificity") (:form . "specificities") (:end . 63)\n  (:start . 50) (:id . 53))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 66) (:start . 64)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 70) (:start . 67)\n  (:id . 55))\n ((:tag . "VBN") (:stem . "propose") (:form . "proposed") (:end . 79)\n  (:start . 71) (:id . 56))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 92)\n  (:start . 80) (:id . 57))\n ((:tag . "IN") (:stem . "between") (:form . "between") (:end . 100)\n  (:start . 93) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 104) (:start . 101)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "various") (:form . "various") (:end . 112)\n  (:start . 105) (:id . 60))\n ((:tag . "NN") (:stem . "msl") (:form . "MSL") (:end . 116) (:start . 113)\n  (:id . 61))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 125)\n  (:start . 117) (:id . 62))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 129) (:start . 126)\n  (:id . 63))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 133) (:start . 130)\n  (:id . 64))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 137) (:start . 134)\n  (:id . 65))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 142) (:start . 138)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 143) (:start . 142)\n  (:id . 67)))@@@1@26@((:identifiers (:sid . :s9.83) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102656@unknown@formal@none@1@S@This could be done by carrying out detailed in vitro studies, which might not be easy to perform; many MSL proteins are difficult to express stably in bacteria or eukaryotic expression systems.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "MD") (:stem . "could") (:form . "could") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "VBN") (:stem . "do") (:form . "done") (:end . 18) (:start . 14)\n  (:id . 45))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 21) (:start . 19)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "carry") (:form . "carrying") (:end . 30)\n  (:start . 22) (:id . 47))\n ((:tag . "RP") (:stem . "out") (:form . "out") (:end . 34) (:start . 31)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "detail") (:form . "detailed") (:end . 43)\n  (:start . 35) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vitro") (:form . "vitro") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "NNS") (:stem . "study") (:form . "studies") (:end . 60)\n  (:start . 53) (:id . 52))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 61) (:start . 60)\n  (:id . 53))\n ((:tag . "WDT") (:stem . "which") (:form . "which") (:end . 67) (:start . 62)\n  (:id . 54))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 73) (:start . 68)\n  (:id . 55))\n ((:tag . "RB") (:stem . "not") (:form . "not") (:end . 77) (:start . 74)\n  (:id . 56))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 80) (:start . 78)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "easy") (:form . "easy") (:end . 85) (:start . 81)\n  (:id . 58))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 88) (:start . 86)\n  (:id . 59))\n ((:tag . "VB") (:stem . "perform") (:form . "perform") (:end . 96)\n  (:start . 89) (:id . 60))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 97) (:start . 96)\n  (:id . 61))\n ((:tag . "JJ") (:stem . "many") (:form . "many") (:end . 102) (:start . 98)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "MSL") (:form . "MSL") (:end . 106) (:start . 103)\n  (:id . 63))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 115)\n  (:start . 107) (:id . 64))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 119) (:start . 116)\n  (:id . 65))\n ((:tag . "JJ") (:stem . "difficult") (:form . "difficult") (:end . 129)\n  (:start . 120) (:id . 66))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 132) (:start . 130)\n  (:id . 67))\n ((:tag . "VB") (:stem . "express") (:form . "express") (:end . 140)\n  (:start . 133) (:id . 68))\n ((:tag . "RB") (:stem . "stably") (:form . "stably") (:end . 147)\n  (:start . 141) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 150) (:start . 148)\n  (:id . 70))\n ((:tag . "NNS") (:stem . "bacteria") (:form . "bacteria") (:end . 159)\n  (:start . 151) (:id . 71))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 162) (:start . 160)\n  (:id . 72))\n ((:tag . "JJ") (:stem . "eukaryotic") (:form . "eukaryotic") (:end . 173)\n  (:start . 163) (:id . 73))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 184)\n  (:start . 174) (:id . 74))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 192)\n  (:start . 185) (:id . 75))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 193) (:start . 192)\n  (:id . 76)))@@@1@35@((:hcues ((:id . :x9.84.2) (:span 68 73)) ((:id . :x9.84.3) (:span 5 10)))\n (:ncues ((:id . :x9.84.1) (:span 74 77)))\n (:hscopes ((:id . :x9.84.2) (:span 68 96)) ((:id . :x9.84.3) (:span 0 96)))\n (:nscopes ((:id . :x9.84.1) (:span 74 96)))\n (:identifiers (:sid . :s9.84) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102657@unknown@formal@none@1@S@An alternative might be to establish a heterologous in vivo system such as yeast, where protein-protein and RNA-protein interactions can be readily detected using sensitive reporter assays.@(((:tag . "DT") (:stem . "an") (:form . "An") (:end . 2) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "alternative") (:form . "alternative") (:end . 14)\n  (:start . 3) (:id . 43))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 20) (:start . 15)\n  (:id . 44))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 23) (:start . 21)\n  (:id . 45))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 26) (:start . 24)\n  (:id . 46))\n ((:tag . "VB") (:stem . "establish") (:form . "establish") (:end . 36)\n  (:start . 27) (:id . 47))\n ((:tag . "DT") (:stem . "a") (:form . "a") (:end . 38) (:start . 37)\n  (:id . 48))\n ((:tag . "JJ") (:stem . "heterologous") (:form . "heterologous") (:end . 51)\n  (:start . 39) (:id . 49))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 54) (:start . 52)\n  (:id . 50))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 59) (:start . 55)\n  (:id . 51))\n ((:tag . "NN") (:stem . "system") (:form . "system") (:end . 66)\n  (:start . 60) (:id . 52))\n ((:tag . "JJ") (:stem . "such") (:form . "such") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "NN") (:stem . "yeast") (:form . "yeast") (:end . 80) (:start . 75)\n  (:id . 55))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 81) (:start . 80)\n  (:id . 56))\n ((:tag . "WRB") (:stem . "where") (:form . "where") (:end . 87) (:start . 82)\n  (:id . 57))\n ((:tag . "JJ") (:stem . "protein-protein") (:form . "protein-protein")\n  (:end . 103) (:start . 88) (:id . 58))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 107) (:start . 104)\n  (:id . 59))\n ((:tag . "JJ") (:stem . "rna-protein") (:form . "RNA-protein") (:end . 119)\n  (:start . 108) (:id . 60))\n ((:tag . "NNS") (:stem . "interaction") (:form . "interactions") (:end . 132)\n  (:start . 120) (:id . 61))\n ((:tag . "MD") (:stem . "can") (:form . "can") (:end . 136) (:start . 133)\n  (:id . 62))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 139) (:start . 137)\n  (:id . 63))\n ((:tag . "RB") (:stem . "readily") (:form . "readily") (:end . 147)\n  (:start . 140) (:id . 64))\n ((:tag . "VBN") (:stem . "detect") (:form . "detected") (:end . 156)\n  (:start . 148) (:id . 65))\n ((:tag . "VBG") (:stem . "use") (:form . "using") (:end . 162) (:start . 157)\n  (:id . 66))\n ((:tag . "JJ") (:stem . "sensitive") (:form . "sensitive") (:end . 172)\n  (:start . 163) (:id . 67))\n ((:tag . "NN") (:stem . "reporter") (:form . "reporter") (:end . 181)\n  (:start . 173) (:id . 68))\n ((:tag . "NNS") (:stem . "assay") (:form . "assays") (:end . 188)\n  (:start . 182) (:id . 69))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 189) (:start . 188)\n  (:id . 70)))@@@1@29@((:hcues ((:id . :x9.85.1) (:span 133 136)) ((:id . :x9.85.2) (:span 15 20)))\n (:hscopes ((:id . :x9.85.1) (:span 88 188))\n  ((:id . :x9.85.2) (:span 15 188)))\n (:identifiers (:sid . :s9.85) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102658@unknown@formal@none@1@S@A second important question is whether the roX genes have the same, overlapping or complementing functions.@(((:tag . "DT") (:stem . "a") (:form . "A") (:end . 1) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "second") (:form . "second") (:end . 8) (:start . 2)\n  (:id . 43))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 18)\n  (:start . 9) (:id . 44))\n ((:tag . "NN") (:stem . "question") (:form . "question") (:end . 27)\n  (:start . 19) (:id . 45))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 30) (:start . 28)\n  (:id . 46))\n ((:tag . "IN") (:stem . "whether") (:form . "whether") (:end . 38)\n  (:start . 31) (:id . 47))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 48))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 46) (:start . 43)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "gene") (:form . "genes") (:end . 52) (:start . 47)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 57) (:start . 53)\n  (:id . 51))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 52))\n ((:tag . "JJ") (:stem . "same") (:form . "same") (:end . 66) (:start . 62)\n  (:id . 53))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 67) (:start . 66)\n  (:id . 54))\n ((:tag . "VBG") (:stem . "overlap") (:form . "overlapping") (:end . 79)\n  (:start . 68) (:id . 55))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 82) (:start . 80)\n  (:id . 56))\n ((:tag . "VBG") (:stem . "complement") (:form . "complementing") (:end . 96)\n  (:start . 83) (:id . 57))\n ((:tag . "NNS") (:stem . "function") (:form . "functions") (:end . 106)\n  (:start . 97) (:id . 58))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 107) (:start . 106)\n  (:id . 59)))@@@1@18@((:hcues ((:id . :x9.86.1) (:span 31 38)))\n (:hscopes ((:id . :x9.86.1) (:span 31 106)))\n (:identifiers (:sid . :s9.86) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102660@unknown@formal@none@1@S@Unfortunately, no roX2 mutations have been recovered yet; they would be important tools for validating the significance of the roX RNAs in vivo.@(((:tag . "RB") (:stem . "unfortunately") (:form . "Unfortunately")\n  (:end . 13) (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 14) (:start . 13)\n  (:id . 43))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 17) (:start . 15)\n  (:id . 44))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 22) (:start . 18)\n  (:id . 45))\n ((:tag . "NNS") (:stem . "mutation") (:form . "mutations") (:end . 32)\n  (:start . 23) (:id . 46))\n ((:tag . "VBP") (:stem . "have") (:form . "have") (:end . 37) (:start . 33)\n  (:id . 47))\n ((:tag . "VBN") (:stem . "be") (:form . "been") (:end . 42) (:start . 38)\n  (:id . 48))\n ((:tag . "VBN") (:stem . "recover") (:form . "recovered") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 56) (:start . 53)\n  (:id . 50))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 57) (:start . 56)\n  (:id . 51))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 62) (:start . 58)\n  (:id . 52))\n ((:tag . "MD") (:stem . "would") (:form . "would") (:end . 68) (:start . 63)\n  (:id . 53))\n ((:tag . "VB") (:stem . "be") (:form . "be") (:end . 71) (:start . 69)\n  (:id . 54))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 81)\n  (:start . 72) (:id . 55))\n ((:tag . "NNS") (:stem . "tool") (:form . "tools") (:end . 87) (:start . 82)\n  (:id . 56))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 91) (:start . 88)\n  (:id . 57))\n ((:tag . "VBG") (:stem . "validate") (:form . "validating") (:end . 102)\n  (:start . 92) (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 106) (:start . 103)\n  (:id . 59))\n ((:tag . "NN") (:stem . "significance") (:form . "significance") (:end . 119)\n  (:start . 107) (:id . 60))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 122) (:start . 120)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 126) (:start . 123)\n  (:id . 62))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 130) (:start . 127)\n  (:id . 63))\n ((:tag . "NNP") (:stem . "RNA") (:form . "RNAs") (:end . 135) (:start . 131)\n  (:id . 64))\n ((:tag . "FW") (:stem . "in") (:form . "in") (:end . 138) (:start . 136)\n  (:id . 65))\n ((:tag . "FW") (:stem . "vivo") (:form . "vivo") (:end . 143) (:start . 139)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 144) (:start . 143)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x9.88.1) (:span 63 68)))\n (:ncues ((:id . :x9.88.2) (:span 15 17)))\n (:hscopes ((:id . :x9.88.1) (:span 63 143)))\n (:nscopes ((:id . :x9.88.2) (:span 15 52)))\n (:identifiers (:sid . :s9.88) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102661@unknown@formal@none@1@S@Furthermore, roX1 and roX2 are only the first two of about 35 chromatin entry sites, although perhaps they are the most important ones.@(((:tag . "RB") (:stem . "furthermore") (:form . "Furthermore") (:end . 11)\n  (:start . 0) (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 12) (:start . 11)\n  (:id . 43))\n ((:tag . "NN") (:stem . "rox1") (:form . "roX1") (:end . 17) (:start . 13)\n  (:id . 44))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 21) (:start . 18)\n  (:id . 45))\n ((:tag . "NN") (:stem . "rox2") (:form . "roX2") (:end . 26) (:start . 22)\n  (:id . 46))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 30) (:start . 27)\n  (:id . 47))\n ((:tag . "RB") (:stem . "only") (:form . "only") (:end . 35) (:start . 31)\n  (:id . 48))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 39) (:start . 36)\n  (:id . 49))\n ((:tag . "JJ") (:stem . "first") (:form . "first") (:end . 45) (:start . 40)\n  (:id . 50))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 49) (:start . 46)\n  (:id . 51))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 52) (:start . 50)\n  (:id . 52))\n ((:tag . "RB") (:stem . "about") (:form . "about") (:end . 58) (:start . 53)\n  (:id . 53))\n ((:tag . "CD") (:stem . "35") (:form . "35") (:end . 61) (:start . 59)\n  (:id . 54))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 71)\n  (:start . 62) (:id . 55))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 77) (:start . 72)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 83) (:start . 78)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 84) (:start . 83)\n  (:id . 58))\n ((:tag . "IN") (:stem . "although") (:form . "although") (:end . 93)\n  (:start . 85) (:id . 59))\n ((:tag . "RB") (:stem . "perhaps") (:form . "perhaps") (:end . 101)\n  (:start . 94) (:id . 60))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 106) (:start . 102)\n  (:id . 61))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 110) (:start . 107)\n  (:id . 62))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 114) (:start . 111)\n  (:id . 63))\n ((:tag . "RBS") (:stem . "most") (:form . "most") (:end . 119) (:start . 115)\n  (:id . 64))\n ((:tag . "JJ") (:stem . "important") (:form . "important") (:end . 129)\n  (:start . 120) (:id . 65))\n ((:tag . "NNS") (:stem . "one") (:form . "ones") (:end . 134) (:start . 130)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 135) (:start . 134)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x9.89.1) (:span 94 101)))\n (:hscopes ((:id . :x9.89.1) (:span 94 134)))\n (:identifiers (:sid . :s9.89) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102662@unknown@formal@none@1@S@The nature of the remaining 33 sites is entirely unclear and there is, as yet, no evidence that they contain other roX-like RNAs.@(((:tag . "DT") (:stem . "the") (:form . "The") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "nature") (:form . "nature") (:end . 10) (:start . 4)\n  (:id . 43))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 13) (:start . 11)\n  (:id . 44))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 17) (:start . 14)\n  (:id . 45))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 27)\n  (:start . 18) (:id . 46))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 30) (:start . 28)\n  (:id . 47))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 36) (:start . 31)\n  (:id . 48))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 39) (:start . 37)\n  (:id . 49))\n ((:tag . "RB") (:stem . "entirely") (:form . "entirely") (:end . 48)\n  (:start . 40) (:id . 50))\n ((:tag . "JJ") (:stem . "unclear") (:form . "unclear") (:end . 56)\n  (:start . 49) (:id . 51))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 60) (:start . 57)\n  (:id . 52))\n ((:tag . "EX") (:stem . "there") (:form . "there") (:end . 66) (:start . 61)\n  (:id . 53))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 54))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 70) (:start . 69)\n  (:id . 55))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 73) (:start . 71)\n  (:id . 56))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 77) (:start . 74)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "no") (:form . "no") (:end . 81) (:start . 79)\n  (:id . 59))\n ((:tag . "NN") (:stem . "evidence") (:form . "evidence") (:end . 90)\n  (:start . 82) (:id . 60))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 95) (:start . 91)\n  (:id . 61))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 100) (:start . 96)\n  (:id . 62))\n ((:tag . "VBP") (:stem . "contain") (:form . "contain") (:end . 108)\n  (:start . 101) (:id . 63))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 114)\n  (:start . 109) (:id . 64))\n ((:tag . "JJ") (:stem . "rox-like") (:form . "roX-like") (:end . 123)\n  (:start . 115) (:id . 65))\n ((:tag . "NNS") (:stem . "rna") (:form . "RNAs") (:end . 128) (:start . 124)\n  (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 129) (:start . 128)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x9.90.1) (:span 79 90)) ((:id . :x9.90.2) (:span 49 56)))\n (:hscopes ((:id . :x9.90.1) (:span 79 128)) ((:id . :x9.90.2) (:span 0 56)))\n (:identifiers (:sid . :s9.90) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102663@unknown@formal@none@1@S@This brings us to the largest of all mysteries, namely how the DCC is spread along the X chromosome.@(((:tag . "DT") (:stem . "this") (:form . "This") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "VBZ") (:stem . "bring") (:form . "brings") (:end . 11) (:start . 5)\n  (:id . 43))\n ((:tag . "PRP") (:stem . "us") (:form . "us") (:end . 14) (:start . 12)\n  (:id . 44))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 17) (:start . 15)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 21) (:start . 18)\n  (:id . 46))\n ((:tag . "JJS") (:stem . "large") (:form . "largest") (:end . 29)\n  (:start . 22) (:id . 47))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 32) (:start . 30)\n  (:id . 48))\n ((:tag . "DT") (:stem . "all") (:form . "all") (:end . 36) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "mystery") (:form . "mysteries") (:end . 46)\n  (:start . 37) (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 47) (:start . 46)\n  (:id . 51))\n ((:tag . "RB") (:stem . "namely") (:form . "namely") (:end . 54)\n  (:start . 48) (:id . 52))\n ((:tag . "WRB") (:stem . "how") (:form . "how") (:end . 58) (:start . 55)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 62) (:start . 59)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "DCC") (:form . "DCC") (:end . 66) (:start . 63)\n  (:id . 55))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 69) (:start . 67)\n  (:id . 56))\n ((:tag . "VBN") (:stem . "spread") (:form . "spread") (:end . 76)\n  (:start . 70) (:id . 57))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 82) (:start . 77)\n  (:id . 58))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 86) (:start . 83)\n  (:id . 59))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 88) (:start . 87)\n  (:id . 60))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 99)\n  (:start . 89) (:id . 61))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 100) (:start . 99)\n  (:id . 62)))@@@1@21@((:identifiers (:sid . :s9.91) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102664@unknown@formal@none@1@S@One possibility is that the remaining 33 or so sites are ''stations' that serve as spreading facilitators in the form of DNA elements.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NN") (:stem . "possibility") (:form . "possibility") (:end . 15)\n  (:start . 4) (:id . 43))\n ((:tag . "VBZ") (:stem . "be") (:form . "is") (:end . 18) (:start . 16)\n  (:id . 44))\n ((:tag . "IN") (:stem . "that") (:form . "that") (:end . 23) (:start . 19)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 27) (:start . 24)\n  (:id . 46))\n ((:tag . "VBG") (:stem . "remain") (:form . "remaining") (:end . 37)\n  (:start . 28) (:id . 47))\n ((:tag . "CD") (:stem . "33") (:form . "33") (:end . 40) (:start . 38)\n  (:id . 48))\n ((:tag . "CC") (:stem . "or") (:form . "or") (:end . 43) (:start . 41)\n  (:id . 49))\n ((:tag . "RB") (:stem . "so") (:form . "so") (:end . 46) (:start . 44)\n  (:id . 50))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 52) (:start . 47)\n  (:id . 51))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 56) (:start . 53)\n  (:id . 52))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 56) (:start . 56)\n  (:id . 53))\n ((:tag . "NNS") (:stem . "stations") (:form . "stations") (:end . 67)\n  (:start . 59) (:id . 54))\n ((:tag . "POS") (:stem . "'") (:form . "’") (:end . 68) (:start . 67)\n  (:id . 55))\n ((:tag . "WDT") (:stem . "that") (:form . "that") (:end . 73) (:start . 69)\n  (:id . 56))\n ((:tag . "VBP") (:stem . "serve") (:form . "serve") (:end . 79) (:start . 74)\n  (:id . 57))\n ((:tag . "IN") (:stem . "as") (:form . "as") (:end . 82) (:start . 80)\n  (:id . 58))\n ((:tag . "VBG") (:stem . "spread") (:form . "spreading") (:end . 92)\n  (:start . 83) (:id . 59))\n ((:tag . "NNS") (:stem . "facilitator") (:form . "facilitators") (:end . 105)\n  (:start . 93) (:id . 60))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 108) (:start . 106)\n  (:id . 61))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 112) (:start . 109)\n  (:id . 62))\n ((:tag . "NN") (:stem . "form") (:form . "form") (:end . 117) (:start . 113)\n  (:id . 63))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 120) (:start . 118)\n  (:id . 64))\n ((:tag . "NN") (:stem . "dna") (:form . "DNA") (:end . 124) (:start . 121)\n  (:id . 65))\n ((:tag . "NNS") (:stem . "element") (:form . "elements") (:end . 133)\n  (:start . 125) (:id . 66))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 134) (:start . 133)\n  (:id . 67)))@@@1@26@((:hcues ((:id . :x9.92.1) (:span 41 43)) ((:id . :x9.92.2) (:span 4 15)))\n (:hscopes ((:id . :x9.92.1) (:span 28 46)) ((:id . :x9.92.2) (:span 4 133)))\n (:identifiers (:sid . :s9.92) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102665@unknown@formal@none@1@S@Thus, primDCCs and/or mature (mat) DCCs, originating from the roX entry sites, might hop from one ''station'' to the next and eventually reach all the entry sites distributed along the entire X chromosome [1].@(((:tag . "RB") (:stem . "thus") (:form . "Thus") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 5) (:start . 4) (:id . 43))\n ((:tag . "NNS") (:stem . "primdcc") (:form . "primDCCs") (:end . 14)\n  (:start . 6) (:id . 44))\n ((:tag . "CC") (:stem . "and/or") (:form . "and/or") (:end . 21)\n  (:start . 15) (:id . 45))\n ((:tag . "JJ") (:stem . "mature") (:form . "mature") (:end . 28)\n  (:start . 22) (:id . 46))\n ((:tag . "(") (:stem . "(") (:form . "(") (:end . 30) (:start . 29)\n  (:id . 47))\n ((:tag . "NN") (:stem . "mat") (:form . "mat") (:end . 33) (:start . 30)\n  (:id . 48))\n ((:tag . ")") (:stem . ")") (:form . ")") (:end . 34) (:start . 33)\n  (:id . 49))\n ((:tag . "NNS") (:stem . "dcc") (:form . "DCCs") (:end . 39) (:start . 35)\n  (:id . 50))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 40) (:start . 39)\n  (:id . 51))\n ((:tag . "VBG") (:stem . "originate") (:form . "originating") (:end . 52)\n  (:start . 41) (:id . 52))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 57) (:start . 53)\n  (:id . 53))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 61) (:start . 58)\n  (:id . 54))\n ((:tag . "NNP") (:stem . "roX") (:form . "roX") (:end . 65) (:start . 62)\n  (:id . 55))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 71) (:start . 66)\n  (:id . 56))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 77) (:start . 72)\n  (:id . 57))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 78) (:start . 77)\n  (:id . 58))\n ((:tag . "MD") (:stem . "might") (:form . "might") (:end . 84) (:start . 79)\n  (:id . 59))\n ((:tag . "VB") (:stem . "hop") (:form . "hop") (:end . 88) (:start . 85)\n  (:id . 60))\n ((:tag . "IN") (:stem . "from") (:form . "from") (:end . 93) (:start . 89)\n  (:id . 61))\n ((:tag . "CD") (:stem . "one") (:form . "one") (:end . 97) (:start . 94)\n  (:id . 62))\n ((:tag . "``") (:stem . "“") (:form . "“") (:end . 97) (:start . 97)\n  (:id . 63))\n ((:tag . "NN") (:stem . "station") (:form . "station") (:end . 107)\n  (:start . 100) (:id . 64))\n ((:tag . "''") (:stem . "”") (:form . "”") (:end . 107) (:start . 107)\n  (:id . 65))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 112) (:start . 110)\n  (:id . 66))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 116) (:start . 113)\n  (:id . 67))\n ((:tag . "JJ") (:stem . "next") (:form . "next") (:end . 121) (:start . 117)\n  (:id . 68))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 125) (:start . 122)\n  (:id . 69))\n ((:tag . "RB") (:stem . "eventually") (:form . "eventually") (:end . 136)\n  (:start . 126) (:id . 70))\n ((:tag . "VB") (:stem . "reach") (:form . "reach") (:end . 142)\n  (:start . 137) (:id . 71))\n ((:tag . "PDT") (:stem . "all") (:form . "all") (:end . 146) (:start . 143)\n  (:id . 72))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 150) (:start . 147)\n  (:id . 73))\n ((:tag . "NN") (:stem . "entry") (:form . "entry") (:end . 156)\n  (:start . 151) (:id . 74))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 162)\n  (:start . 157) (:id . 75))\n ((:tag . "VBN") (:stem . "distribute") (:form . "distributed") (:end . 174)\n  (:start . 163) (:id . 76))\n ((:tag . "IN") (:stem . "along") (:form . "along") (:end . 180)\n  (:start . 175) (:id . 77))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 184) (:start . 181)\n  (:id . 78))\n ((:tag . "JJ") (:stem . "entire") (:form . "entire") (:end . 191)\n  (:start . 185) (:id . 79))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 193) (:start . 192)\n  (:id . 80))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 204)\n  (:start . 194) (:id . 81))\n ((:tag . "(") (:stem . "[") (:form . "[") (:end . 206) (:start . 205)\n  (:id . 82))\n ((:tag . "CD") (:stem . "1") (:form . "1") (:end . 207) (:start . 206)\n  (:id . 83))\n ((:tag . ")") (:stem . "]") (:form . "]") (:end . 208) (:start . 207)\n  (:id . 84))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 209) (:start . 208)\n  (:id . 85)))@@@1@44@((:hcues ((:id . :x9.93.1) (:span 79 84)))\n (:hscopes ((:id . :x9.93.1) (:span 79 204)))\n (:identifiers (:sid . :s9.93) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102666@unknown@formal@none@1@S@From these sites, they then reach into the neighboring chromatin regions by yet another mechanism.@(((:tag . "IN") (:stem . "from") (:form . "From") (:end . 4) (:start . 0)\n  (:id . 42))\n ((:tag . "DT") (:stem . "these") (:form . "these") (:end . 10) (:start . 5)\n  (:id . 43))\n ((:tag . "NNS") (:stem . "site") (:form . "sites") (:end . 16) (:start . 11)\n  (:id . 44))\n ((:tag . ",") (:stem . ",") (:form . ",") (:end . 17) (:start . 16)\n  (:id . 45))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 22) (:start . 18)\n  (:id . 46))\n ((:tag . "RB") (:stem . "then") (:form . "then") (:end . 27) (:start . 23)\n  (:id . 47))\n ((:tag . "VBP") (:stem . "reach") (:form . "reach") (:end . 33) (:start . 28)\n  (:id . 48))\n ((:tag . "IN") (:stem . "into") (:form . "into") (:end . 38) (:start . 34)\n  (:id . 49))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 42) (:start . 39)\n  (:id . 50))\n ((:tag . "VBG") (:stem . "neighbor") (:form . "neighboring") (:end . 54)\n  (:start . 43) (:id . 51))\n ((:tag . "NN") (:stem . "chromatin") (:form . "chromatin") (:end . 64)\n  (:start . 55) (:id . 52))\n ((:tag . "NNS") (:stem . "region") (:form . "regions") (:end . 72)\n  (:start . 65) (:id . 53))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 75) (:start . 73)\n  (:id . 54))\n ((:tag . "RB") (:stem . "yet") (:form . "yet") (:end . 79) (:start . 76)\n  (:id . 55))\n ((:tag . "DT") (:stem . "another") (:form . "another") (:end . 87)\n  (:start . 80) (:id . 56))\n ((:tag . "NN") (:stem . "mechanism") (:form . "mechanism") (:end . 97)\n  (:start . 88) (:id . 57))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 98) (:start . 97)\n  (:id . 58)))@@@1@17@((:identifiers (:sid . :s9.94) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102667@unknown@formal@none@1@S@One final thought: the dosage compensation machinery in C. elegans acts on the two X chromosomes in the hermaphrodite by twofold down-regulation of gene expression.@(((:tag . "CD") (:stem . "one") (:form . "One") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "JJ") (:stem . "final") (:form . "final") (:end . 9) (:start . 4)\n  (:id . 43))\n ((:tag . "NN") (:stem . "thought") (:form . "thought") (:end . 17)\n  (:start . 10) (:id . 44))\n ((:tag . ":") (:stem . ":") (:form . ":") (:end . 18) (:start . 17)\n  (:id . 45))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 22) (:start . 19)\n  (:id . 46))\n ((:tag . "NN") (:stem . "dosage") (:form . "dosage") (:end . 29)\n  (:start . 23) (:id . 47))\n ((:tag . "NN") (:stem . "compensation") (:form . "compensation") (:end . 42)\n  (:start . 30) (:id . 48))\n ((:tag . "NN") (:stem . "machinery") (:form . "machinery") (:end . 52)\n  (:start . 43) (:id . 49))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 55) (:start . 53)\n  (:id . 50))\n ((:tag . "NNP") (:stem . "C.") (:form . "C.") (:end . 58) (:start . 56)\n  (:id . 51))\n ((:tag . "NNP") (:stem . "elegans") (:form . "elegans") (:end . 66)\n  (:start . 59) (:id . 52))\n ((:tag . "VBZ") (:stem . "act") (:form . "acts") (:end . 71) (:start . 67)\n  (:id . 53))\n ((:tag . "IN") (:stem . "on") (:form . "on") (:end . 74) (:start . 72)\n  (:id . 54))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 78) (:start . 75)\n  (:id . 55))\n ((:tag . "CD") (:stem . "two") (:form . "two") (:end . 82) (:start . 79)\n  (:id . 56))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 84) (:start . 83)\n  (:id . 57))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 96)\n  (:start . 85) (:id . 58))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 99) (:start . 97)\n  (:id . 59))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "NN") (:stem . "hermaphrodite") (:form . "hermaphrodite")\n  (:end . 117) (:start . 104) (:id . 61))\n ((:tag . "IN") (:stem . "by") (:form . "by") (:end . 120) (:start . 118)\n  (:id . 62))\n ((:tag . "JJ") (:stem . "twofold") (:form . "twofold") (:end . 128)\n  (:start . 121) (:id . 63))\n ((:tag . "NN") (:stem . "down-regulation") (:form . "down-regulation")\n  (:end . 144) (:start . 129) (:id . 64))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 147) (:start . 145)\n  (:id . 65))\n ((:tag . "NN") (:stem . "gene") (:form . "gene") (:end . 152) (:start . 148)\n  (:id . 66))\n ((:tag . "NN") (:stem . "expression") (:form . "expression") (:end . 163)\n  (:start . 153) (:id . 67))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 164) (:start . 163)\n  (:id . 68)))@@@1@27@((:identifiers (:sid . :s9.95) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011
5102668@unknown@formal@none@1@S@Six proteins are essential for this process and they associate with the X chromosomes; four of them are related to factors involved in chromosome condensation during mitosis in other systems.@(((:tag . "CD") (:stem . "six") (:form . "Six") (:end . 3) (:start . 0)\n  (:id . 42))\n ((:tag . "NNS") (:stem . "protein") (:form . "proteins") (:end . 12)\n  (:start . 4) (:id . 43))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 16) (:start . 13)\n  (:id . 44))\n ((:tag . "JJ") (:stem . "essential") (:form . "essential") (:end . 26)\n  (:start . 17) (:id . 45))\n ((:tag . "IN") (:stem . "for") (:form . "for") (:end . 30) (:start . 27)\n  (:id . 46))\n ((:tag . "DT") (:stem . "this") (:form . "this") (:end . 35) (:start . 31)\n  (:id . 47))\n ((:tag . "NN") (:stem . "process") (:form . "process") (:end . 43)\n  (:start . 36) (:id . 48))\n ((:tag . "CC") (:stem . "and") (:form . "and") (:end . 47) (:start . 44)\n  (:id . 49))\n ((:tag . "PRP") (:stem . "they") (:form . "they") (:end . 52) (:start . 48)\n  (:id . 50))\n ((:tag . "VBP") (:stem . "associate") (:form . "associate") (:end . 62)\n  (:start . 53) (:id . 51))\n ((:tag . "IN") (:stem . "with") (:form . "with") (:end . 67) (:start . 63)\n  (:id . 52))\n ((:tag . "DT") (:stem . "the") (:form . "the") (:end . 71) (:start . 68)\n  (:id . 53))\n ((:tag . "NNP") (:stem . "X") (:form . "X") (:end . 73) (:start . 72)\n  (:id . 54))\n ((:tag . "NNS") (:stem . "chromosome") (:form . "chromosomes") (:end . 85)\n  (:start . 74) (:id . 55))\n ((:tag . ":") (:stem . ";") (:form . ";") (:end . 86) (:start . 85)\n  (:id . 56))\n ((:tag . "CD") (:stem . "four") (:form . "four") (:end . 91) (:start . 87)\n  (:id . 57))\n ((:tag . "IN") (:stem . "of") (:form . "of") (:end . 94) (:start . 92)\n  (:id . 58))\n ((:tag . "PRP") (:stem . "them") (:form . "them") (:end . 99) (:start . 95)\n  (:id . 59))\n ((:tag . "VBP") (:stem . "be") (:form . "are") (:end . 103) (:start . 100)\n  (:id . 60))\n ((:tag . "VBN") (:stem . "relate") (:form . "related") (:end . 111)\n  (:start . 104) (:id . 61))\n ((:tag . "TO") (:stem . "to") (:form . "to") (:end . 114) (:start . 112)\n  (:id . 62))\n ((:tag . "NNS") (:stem . "factor") (:form . "factors") (:end . 122)\n  (:start . 115) (:id . 63))\n ((:tag . "VBN") (:stem . "involve") (:form . "involved") (:end . 131)\n  (:start . 123) (:id . 64))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 134) (:start . 132)\n  (:id . 65))\n ((:tag . "NN") (:stem . "chromosome") (:form . "chromosome") (:end . 145)\n  (:start . 135) (:id . 66))\n ((:tag . "NN") (:stem . "condensation") (:form . "condensation") (:end . 158)\n  (:start . 146) (:id . 67))\n ((:tag . "IN") (:stem . "during") (:form . "during") (:end . 165)\n  (:start . 159) (:id . 68))\n ((:tag . "NN") (:stem . "mitosis") (:form . "mitosis") (:end . 173)\n  (:start . 166) (:id . 69))\n ((:tag . "IN") (:stem . "in") (:form . "in") (:end . 176) (:start . 174)\n  (:id . 70))\n ((:tag . "JJ") (:stem . "other") (:form . "other") (:end . 182)\n  (:start . 177) (:id . 71))\n ((:tag . "NNS") (:stem . "system") (:form . "systems") (:end . 190)\n  (:start . 183) (:id . 72))\n ((:tag . ".") (:stem . ".") (:form . ".") (:end . 191) (:start . 190)\n  (:id . 73)))@@@1@32@((:identifiers (:sid . :s9.96) (:did . :pmc138894) (:did-type . :pmcid)\n  (:dtype . :|Biological_full_article|) (:dpart . :|Text|)))@oe@9-2-2011